locus-tag	class	description
GPY46_RS00025	COG0242	peptide deformylase activity
GPY46_RS00075	COG2176	DNA-directed DNA polymerase activity
GPY46_RS00080	COG0583	DNA-binding transcription factor activity
GPY46_RS00085	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY46_RS00090	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY46_RS00115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY46_RS00115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY46_RS00120	COG0509	glycine decarboxylation via glycine cleavage system
GPY46_RS00125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY46_RS00145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY46_RS00165	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY46_RS00165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY46_RS00165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY46_RS00170	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY46_RS00175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY46_RS00175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY46_RS00180	COG1609	Transcriptional regulator
GPY46_RS00200	COG2199	diguanylate cyclase activity
GPY46_RS00200	COG2200	EAL domain
GPY46_RS00200	COG2203	Gaf domain
GPY46_RS00205	COG0765	amino acid transport
GPY46_RS00210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY46_RS00215	COG0765	amino acid transport
GPY46_RS00220	COG1126	abc transporter atp-binding protein
GPY46_RS00225	COG0469	pyruvate kinase activity
GPY46_RS00230	COG2271	Major facilitator Superfamily
GPY46_RS00235	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY46_RS00255	COG1979	alcohol dehydrogenase
GPY46_RS00260	COG2207	Transcriptional regulator
GPY46_RS00275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY46_RS00280	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY46_RS00285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY46_RS00305	COG0784	Response regulator, receiver
GPY46_RS00305	COG3437	response regulator, receiver
GPY46_RS00315	COG0546	phosphoglycolate phosphatase activity
GPY46_RS00320	COG0840	transmembrane signaling receptor activity
GPY46_RS00330	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY46_RS00335	COG0513	Belongs to the DEAD box helicase family
GPY46_RS00340	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY46_RS00355	COG3038	cytochrome b561
GPY46_RS00360	COG2353	YceI-like domain
GPY46_RS00365	COG2116	formate transmembrane transporter activity
GPY46_RS00370	COG0583	DNA-binding transcription factor activity
GPY46_RS00380	COG3593	DNA synthesis involved in DNA repair
GPY46_RS00385	COG0737	Belongs to the 5'-nucleotidase family
GPY46_RS00390	COG0861	Integral membrane protein TerC family
GPY46_RS00405	COG2267	carboxylic ester hydrolase activity
GPY46_RS00410	COG2067	long-chain fatty acid transport protein
GPY46_RS00425	COG2050	protein possibly involved in aromatic compounds catabolism
GPY46_RS00435	COG4533	DNA binding
GPY46_RS00460	COG0484	heat shock protein binding
GPY46_RS00470	COG3300	MHYT domain
GPY46_RS00470	COG5001	Diguanylate cyclase
GPY46_RS00475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY46_RS00485	COG4181	ATPase activity
GPY46_RS00490	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY46_RS00500	COG1984	allophanate hydrolase subunit 2
GPY46_RS00505	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY46_RS00510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY46_RS00515	COG5002	protein histidine kinase activity
GPY46_RS00515	COG5001	Diguanylate cyclase
GPY46_RS00515	COG3447	MASE1 domain protein
GPY46_RS00520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY46_RS00530	COG4771	TonB-dependent receptor
GPY46_RS00530	COG1629	transport
GPY46_RS00535	COG0583	DNA-binding transcription factor activity
GPY46_RS00540	COG1042	CoA-binding domain protein
GPY46_RS00540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY46_RS00540	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY46_RS00550	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY46_RS00560	COG0023	Translation Initiation Factor
GPY46_RS00750	COG0642	Histidine kinase
GPY46_RS00895	COG0583	DNA-binding transcription factor activity
GPY46_RS00905	COG0589	response to stress
GPY46_RS00910	COG3140	Belongs to the UPF0181 family
GPY46_RS00935	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY46_RS00940	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY46_RS00955	COG0745	RESPONSE REGULATOR receiver
GPY46_RS00955	COG3706	GGDEF domain
GPY46_RS00965	COG3706	GGDEF domain
GPY46_RS00965	COG5001	Diguanylate cyclase
GPY46_RS00965	COG2203	Gaf domain
GPY46_RS00965	COG4251	negative regulation of phosphorylation
GPY46_RS00975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY46_RS00980	COG4149	molybdate abc transporter
GPY46_RS00985	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY46_RS00990	COG1492	cobalamin metabolic process
GPY46_RS00995	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY46_RS01005	COG4067	protein conserved in archaea
GPY46_RS01005	COG0189	ligase activity
GPY46_RS01025	COG0534	Mate efflux family protein
GPY46_RS01030	COG0602	queuosine metabolic process
GPY46_RS01035	COG1328	CTP reductase activity
GPY46_RS01050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY46_RS01080	COG0243	molybdopterin cofactor binding
GPY46_RS01090	COG0583	DNA-binding transcription factor activity
GPY46_RS01095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY46_RS01105	COG2197	response regulator
GPY46_RS01110	COG3851	Histidine kinase
GPY46_RS01115	COG2271	Major facilitator Superfamily
GPY46_RS01140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY46_RS01145	COG3118	belongs to the thioredoxin family
GPY46_RS01150	COG2814	Major facilitator Superfamily
GPY46_RS01160	COG0534	Mate efflux family protein
GPY46_RS01190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY46_RS01210	COG2116	formate transmembrane transporter activity
GPY46_RS01215	COG2146	nitrite reductase [NAD(P)H] activity
GPY46_RS01220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY46_RS01225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY46_RS01265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY46_RS01265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY46_RS01310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY46_RS01330	COG0277	FAD linked oxidase domain protein
GPY46_RS01335	COG0583	DNA-binding transcription factor activity
GPY46_RS01355	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY46_RS01370	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY46_RS01385	COG1288	antiporter activity
GPY46_RS01395	COG2814	Major facilitator Superfamily
GPY46_RS01405	COG3040	lipid binding
GPY46_RS01425	COG0419	ATPase involved in DNA repair
GPY46_RS01430	COG0420	3'-5' exonuclease activity
GPY46_RS01445	COG3501	Rhs element vgr protein
GPY46_RS01500	COG0631	protein serine/threonine phosphatase activity
GPY46_RS01535	COG0515	serine threonine protein kinase
GPY46_RS01535	COG2815	serine threonine protein kinase
GPY46_RS01590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY46_RS01590	COG2146	nitrite reductase [NAD(P)H] activity
GPY46_RS01595	COG1116	anion transmembrane transporter activity
GPY46_RS01600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY46_RS01605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY46_RS01615	COG3707	response regulator
GPY46_RS01635	COG1648	precorrin-2 dehydrogenase activity
GPY46_RS01635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY46_RS01640	COG0243	molybdopterin cofactor binding
GPY46_RS01645	COG0456	acetyltransferase
GPY46_RS01650	COG0814	amino acid
GPY46_RS01660	COG3706	GGDEF domain
GPY46_RS01660	COG0745	RESPONSE REGULATOR receiver
GPY46_RS01680	COG1785	Belongs to the alkaline phosphatase family
GPY46_RS01695	COG0745	RESPONSE REGULATOR receiver
GPY46_RS01725	COG2847	Copper chaperone PCu(A)C
GPY46_RS01730	COG0443	Heat shock 70 kDa protein
GPY46_RS01765	COG0625	glutathione transferase activity
GPY46_RS01780	COG4160	amino acid transport
GPY46_RS01785	COG4215	(ABC) transporter
GPY46_RS01790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY46_RS01795	COG1126	abc transporter atp-binding protein
GPY46_RS01830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY46_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
GPY46_RS01860	COG1902	pentaerythritol trinitrate reductase activity
GPY46_RS01875	COG0109	protoheme IX farnesyltransferase activity
GPY46_RS01880	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY46_RS01885	COG1845	cytochrome c oxidase, subunit III
GPY46_RS01890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY46_RS01895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY46_RS01900	COG1028	Short-chain dehydrogenase reductase Sdr
GPY46_RS01910	COG1024	Enoyl-CoA hydratase
GPY46_RS01930	COG0183	Belongs to the thiolase family
GPY46_RS01940	COG1960	acyl-CoA dehydrogenase activity
GPY46_RS01945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY46_RS01950	COG1024	Enoyl-CoA hydratase
GPY46_RS01960	COG5413	integral membrane protein
GPY46_RS01975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY46_RS01985	COG5001	Diguanylate cyclase
GPY46_RS01990	COG0513	Belongs to the DEAD box helicase family
GPY46_RS01995	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY46_RS02010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY46_RS02025	COG0582	viral genome integration into host DNA
GPY46_RS02085	COG0641	radical SAM
GPY46_RS02110	COG0840	transmembrane signaling receptor activity
GPY46_RS02115	COG1119	ATPase activity
GPY46_RS02120	COG2200	EAL domain
GPY46_RS02140	COG0513	Belongs to the DEAD box helicase family
GPY46_RS02145	COG0523	cobalamin synthesis protein
GPY46_RS02155	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY46_RS02165	COG0133	tryptophan synthase activity
GPY46_RS02170	COG4628	conserved protein (DUF2132)
GPY46_RS02175	COG0513	Belongs to the DEAD box helicase family
GPY46_RS02180	COG3530	Putative quorum-sensing-regulated virulence factor
GPY46_RS02205	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY46_RS02210	COG3186	Phenylalanine-4-hydroxylase
GPY46_RS02215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY46_RS02220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY46_RS02260	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY46_RS02265	COG1454	alcohol dehydrogenase
GPY46_RS02270	COG2133	pyrroloquinoline quinone binding
GPY46_RS02280	COG0783	Belongs to the Dps family
GPY46_RS02285	COG0840	transmembrane signaling receptor activity
GPY46_RS02295	COG0577	efflux transmembrane transporter activity
GPY46_RS02295	COG1136	(ABC) transporter
GPY46_RS02315	COG2199	diguanylate cyclase activity
GPY46_RS02330	COG3036	rescue of stalled ribosome
GPY46_RS02335	COG1278	Cold shock
GPY46_RS02370	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY46_RS02375	COG0109	protoheme IX farnesyltransferase activity
GPY46_RS02380	COG1612	heme a metabolic process
GPY46_RS02405	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY46_RS02415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY46_RS02420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY46_RS02430	COG1280	lysine exporter protein (LysE YggA)
GPY46_RS02460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY46_RS02465	COG0697	spore germination
GPY46_RS02490	COG2814	Major facilitator Superfamily
GPY46_RS02495	COG0583	DNA-binding transcription factor activity
GPY46_RS02500	COG5001	Diguanylate cyclase
GPY46_RS02505	COG0739	heme binding
GPY46_RS02545	COG0814	amino acid
GPY46_RS02565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY46_RS02570	COG1072	(Pantothenic acid kinase))
GPY46_RS02580	COG1063	alcohol dehydrogenase
GPY46_RS02585	COG2213	PTS system mannitol-specific
GPY46_RS02590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY46_RS02610	COG0798	PFAM Bile acid sodium symporter
GPY46_RS02620	COG1881	PFAM PEBP family protein
GPY46_RS02630	COG2706	6-phosphogluconolactonase activity
GPY46_RS02645	COG1131	(ABC) transporter
GPY46_RS02650	COG0842	Transport permease protein
GPY46_RS02665	COG3383	formate dehydrogenase (NAD+) activity
GPY46_RS02690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY46_RS02710	COG2203	Gaf domain
GPY46_RS02710	COG2199	diguanylate cyclase activity
GPY46_RS02720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY46_RS02730	COG2067	long-chain fatty acid transport protein
GPY46_RS02740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY46_RS02750	COG1505	serine-type exopeptidase activity
GPY46_RS02755	COG0488	(ABC) transporter
GPY46_RS02760	COG0589	response to stress
GPY46_RS02765	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY46_RS02785	COG0366	Alpha amylase catalytic
GPY46_RS02795	COG4934	collagen metabolic process
GPY46_RS02810	COG0583	DNA-binding transcription factor activity
GPY46_RS02820	COG0783	Belongs to the Dps family
GPY46_RS02825	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY46_RS02850	COG2169	Transcriptional regulator
GPY46_RS02855	COG1486	melibiose metabolic process
GPY46_RS02860	COG2211	Major facilitator Superfamily
GPY46_RS02880	COG0758	DNA mediated transformation
GPY46_RS02905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY46_RS02915	COG0835	chemotaxis
GPY46_RS02915	COG0784	Response regulator, receiver
GPY46_RS02925	COG0748	coenzyme F420 binding
GPY46_RS02930	COG3721	Heme iron utilization protein
GPY46_RS02940	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY46_RS02945	COG0811	peptide transport
GPY46_RS02950	COG0848	biopolymer transport protein
GPY46_RS02960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY46_RS02965	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY46_RS03005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY46_RS03010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY46_RS03015	COG0633	Ferredoxin
GPY46_RS03015	COG3217	Mosc domain protein beta barrel domain protein
GPY46_RS03015	COG0633	Ferredoxin
GPY46_RS03015	COG3217	Mosc domain protein beta barrel domain protein
GPY46_RS03025	COG0401	homolog of Blt101
GPY46_RS03035	COG0418	dihydroorotase activity
GPY46_RS03040	COG2354	Protein conserved in bacteria
GPY46_RS03070	COG3833	ABC-type maltose transport systems, permease component
GPY46_RS03075	COG1175	transmembrane transport
GPY46_RS03085	COG3842	ATPase activity
GPY46_RS03115	COG0438	transferase activity, transferring glycosyl groups
GPY46_RS03150	COG1309	transcriptional regulator
GPY46_RS03155	COG2130	NADP-dependent
GPY46_RS03165	COG0753	catalase activity
GPY46_RS03170	COG2084	Dehydrogenase
GPY46_RS03175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY46_RS03180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY46_RS03190	COG2207	Transcriptional regulator
GPY46_RS03195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY46_RS03195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY46_RS03195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY46_RS03210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY46_RS03215	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY46_RS03225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY46_RS03230	COG0569	domain protein
GPY46_RS03240	COG5002	protein histidine kinase activity
GPY46_RS03245	COG1132	(ABC) transporter
GPY46_RS03250	COG4774	siderophore transport
GPY46_RS03255	COG1120	ATPase activity
GPY46_RS03275	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GPY46_RS03275	COG2885	chlorophyll binding
GPY46_RS03310	COG2197	response regulator
GPY46_RS03320	COG0840	transmembrane signaling receptor activity
GPY46_RS03330	COG0714	Associated with various cellular activities
GPY46_RS03350	COG2304	oxidoreductase activity
GPY46_RS03365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY46_RS03370	COG0581	inorganic phosphate transmembrane transporter activity
GPY46_RS03375	COG0573	inorganic phosphate transmembrane transporter activity
GPY46_RS03380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY46_RS03405	COG4771	TonB-dependent receptor
GPY46_RS03410	COG1770	oligopeptidase
GPY46_RS03415	COG0513	Belongs to the DEAD box helicase family
GPY46_RS03425	COG1376	ErfK ybiS ycfS ynhG family protein
GPY46_RS03425	COG1388	LysM domain
GPY46_RS03430	COG0415	Belongs to the DNA photolyase family
GPY46_RS03435	COG0789	Transcriptional regulator
GPY46_RS03440	COG3272	Protein of unknown function (DUF1722)
GPY46_RS03450	COG0813	purine-nucleoside phosphorylase activity
GPY46_RS03465	COG3706	GGDEF domain
GPY46_RS03475	COG1566	PFAM secretion protein HlyD family protein
GPY46_RS03480	COG4720	Psort location CytoplasmicMembrane, score
GPY46_RS03485	COG1122	ATPase activity
GPY46_RS03500	COG0348	domain, Protein
GPY46_RS03505	COG0437	4 iron, 4 sulfur cluster binding
GPY46_RS03510	COG1247	-acetyltransferase
GPY46_RS03540	COG1067	ATP-dependent peptidase activity
GPY46_RS03550	COG4172	Belongs to the ABC transporter superfamily
GPY46_RS03555	COG1505	serine-type exopeptidase activity
GPY46_RS03560	COG0583	DNA-binding transcription factor activity
GPY46_RS03565	COG1620	l-lactate permease
GPY46_RS03570	COG1304	FMN binding
GPY46_RS03580	COG0668	transmembrane transport
GPY46_RS03620	COG1063	alcohol dehydrogenase
GPY46_RS03625	COG0156	8-amino-7-oxononanoate synthase activity
GPY46_RS03635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY46_RS03655	COG0745	RESPONSE REGULATOR receiver
GPY46_RS03690	COG0346	lactoylglutathione lyase activity
GPY46_RS03710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY46_RS03750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY46_RS03765	COG2204	response regulator
GPY46_RS03790	COG1987	bacterial-type flagellum assembly
GPY46_RS03800	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY46_RS03815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY46_RS03825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY46_RS03830	COG1516	flagellar protein fliS
GPY46_RS03845	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY46_RS03850	COG1191	sigma factor activity
GPY46_RS03855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY46_RS03860	COG1360	Flagellar Motor Protein
GPY46_RS03915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY46_RS03920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY46_RS03930	COG0454	-acetyltransferase
GPY46_RS03945	COG2814	Major facilitator Superfamily
GPY46_RS03990	COG0628	permease
GPY46_RS03995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY46_RS04005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY46_RS04015	COG4628	conserved protein (DUF2132)
GPY46_RS04020	COG0583	DNA-binding transcription factor activity
GPY46_RS04045	COG1686	Belongs to the peptidase S11 family
GPY46_RS04065	COG3397	chitin binding
GPY46_RS04070	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY46_RS04075	COG2095	MarC family integral membrane protein
GPY46_RS04090	COG1596	polysaccharide export
GPY46_RS04095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY46_RS04115	COG0583	DNA-binding transcription factor activity
GPY46_RS04125	COG1301	dicarboxylic acid transport
GPY46_RS04140	COG3339	Conserved Protein
GPY46_RS04145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY46_RS04150	COG0700	Nucleoside recognition
GPY46_RS04155	COG3366	ferrous iron transmembrane transporter activity
GPY46_RS04170	COG0366	Alpha amylase catalytic
GPY46_RS04175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY46_RS04180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY46_RS04185	COG1640	4-alpha-glucanotransferase
GPY46_RS04190	COG0058	SHG alpha-glucan phosphorylase activity
GPY46_RS04205	COG2909	trisaccharide binding
GPY46_RS04220	COG1999	signal sequence binding
GPY46_RS04230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY46_RS04230	COG1263	PTS System
GPY46_RS04235	COG1162	GTPase activity
GPY46_RS04240	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY46_RS04250	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY46_RS04260	COG0531	amino acid
GPY46_RS04265	COG1982	Orn Lys Arg decarboxylase major
GPY46_RS04285	COG2356	endonuclease I
GPY46_RS04310	COG4580	involved in the transport of maltose and maltodextrins
GPY46_RS04325	COG2814	Major facilitator Superfamily
GPY46_RS04335	COG0739	heme binding
GPY46_RS04345	COG0612	Peptidase, M16
GPY46_RS04355	COG1120	ATPase activity
GPY46_RS04360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY46_RS04365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY46_RS04370	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY46_RS04375	COG4772	TonB-dependent receptor
GPY46_RS04400	COG4264	IucA IucC family
GPY46_RS04405	COG0019	diaminopimelate decarboxylase activity
GPY46_RS04410	COG1653	transport
GPY46_RS04420	COG0745	RESPONSE REGULATOR receiver
GPY46_RS04460	COG0463	Glycosyl transferase, family 2
GPY46_RS04480	COG1764	response to oxidative stress
GPY46_RS04485	COG1846	Transcriptional regulator
GPY46_RS04490	COG0450	alkyl hydroperoxide reductase
GPY46_RS04495	COG3634	alkyl hydroperoxide reductase activity
GPY46_RS04525	COG1595	DNA-templated transcription, initiation
GPY46_RS04540	COG0840	transmembrane signaling receptor activity
GPY46_RS04545	COG0583	DNA-binding transcription factor activity
GPY46_RS04550	COG1486	melibiose metabolic process
GPY46_RS04565	COG2258	MOSC domain
GPY46_RS04570	COG0513	Belongs to the DEAD box helicase family
GPY46_RS04585	COG2207	Transcriptional regulator
GPY46_RS04595	COG1132	(ABC) transporter
GPY46_RS04640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY46_RS04670	COG0259	pyridoxamine-phosphate oxidase activity
GPY46_RS04735	COG4166	transmembrane transport
GPY46_RS04755	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY46_RS04760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY46_RS04760	COG1263	PTS System
GPY46_RS04770	COG3340	Belongs to the peptidase S51 family
GPY46_RS04790	COG1444	tRNA N-acetyltransferase activity
GPY46_RS04815	COG4608	Belongs to the ABC transporter superfamily
GPY46_RS04820	COG0444	Belongs to the ABC transporter superfamily
GPY46_RS04830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY46_RS04830	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY46_RS04855	COG0217	transcriptional regulatory protein
GPY46_RS04860	COG0772	Belongs to the SEDS family
GPY46_RS04895	COG3275	phosphorelay sensor kinase activity
GPY46_RS04900	COG3279	Response regulator of the LytR AlgR family
GPY46_RS04910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY46_RS04945	COG0786	glutamate:sodium symporter activity
GPY46_RS04955	COG1131	(ABC) transporter
GPY46_RS04960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY46_RS04965	COG0786	glutamate:sodium symporter activity
GPY46_RS04980	COG0363	glucosamine-6-phosphate deaminase activity
GPY46_RS05000	COG1741	Belongs to the pirin family
GPY46_RS05005	COG2259	Doxx family
GPY46_RS05020	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY46_RS05025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY46_RS05035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY46_RS05075	COG3123	guanosine phosphorylase activity
GPY46_RS05085	COG5001	Diguanylate cyclase
GPY46_RS05095	COG0534	Mate efflux family protein
GPY46_RS05100	COG0564	pseudouridine synthase activity
GPY46_RS05115	COG0583	DNA-binding transcription factor activity
GPY46_RS05120	COG0561	phosphatase activity
GPY46_RS05130	COG2199	diguanylate cyclase activity
GPY46_RS05145	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY46_RS05150	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY46_RS05155	COG0583	DNA-binding transcription factor activity
GPY46_RS05170	COG1414	Transcriptional regulator
GPY46_RS05175	COG1028	Short-chain dehydrogenase reductase Sdr
GPY46_RS05185	COG1917	Cupin 2, conserved barrel domain protein
GPY46_RS05200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY46_RS05205	COG0800	Aldolase
GPY46_RS05225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY46_RS05230	COG0823	Involved in the tonB-independent uptake of proteins
GPY46_RS05235	COG2375	cellular response to nickel ion
GPY46_RS05265	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY46_RS05270	COG3047	cAMP biosynthetic process
GPY46_RS05300	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GPY46_RS05300	COG3408	Glycogen debranching enzyme
GPY46_RS05305	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GPY46_RS05315	COG0583	DNA-binding transcription factor activity
GPY46_RS05325	COG0583	DNA-binding transcription factor activity
GPY46_RS05340	COG0546	phosphoglycolate phosphatase activity
GPY46_RS05365	COG3835	regulator
GPY46_RS05370	COG2610	gluconate transmembrane transporter activity
GPY46_RS05375	COG1929	Belongs to the glycerate kinase type-1 family
GPY46_RS05380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY46_RS05400	COG0456	acetyltransferase
GPY46_RS05415	COG1028	Short-chain dehydrogenase reductase Sdr
GPY46_RS05425	COG3005	denitrification pathway
GPY46_RS05430	COG0243	molybdopterin cofactor binding
GPY46_RS05440	COG0352	thiamine-phosphate diphosphorylase activity
GPY46_RS05445	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GPY46_RS05450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY46_RS05455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY46_RS05460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY46_RS05465	COG1116	anion transmembrane transporter activity
GPY46_RS05470	COG0351	phosphomethylpyrimidine kinase
GPY46_RS05480	COG0312	modulator of DNA gyrase
GPY46_RS05485	COG0312	modulator of DNA gyrase
GPY46_RS05490	COG1901	pseudouridine methyltransferase
GPY46_RS05545	COG0582	viral genome integration into host DNA
GPY46_RS05605	COG2814	Major facilitator Superfamily
GPY46_RS05610	COG0583	DNA-binding transcription factor activity
GPY46_RS05630	COG1902	pentaerythritol trinitrate reductase activity
GPY46_RS05635	COG1902	pentaerythritol trinitrate reductase activity
GPY46_RS05655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY46_RS05670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY46_RS05680	COG0584	glycerophosphoryl diester phosphodiesterase
GPY46_RS05690	COG0745	RESPONSE REGULATOR receiver
GPY46_RS05710	COG0811	peptide transport
GPY46_RS05715	COG0811	peptide transport
GPY46_RS05720	COG0848	biopolymer transport protein
GPY46_RS05760	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPY46_RS05765	COG1121	(ABC) transporter
GPY46_RS05770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY46_RS05785	COG1770	oligopeptidase
GPY46_RS05790	COG2814	Major facilitator Superfamily
GPY46_RS05795	COG0010	Belongs to the arginase family
GPY46_RS05800	COG1166	arginine decarboxylase activity
GPY46_RS05810	COG4067	protein conserved in archaea
GPY46_RS05810	COG0189	ligase activity
GPY46_RS05815	COG0189	ligase activity
GPY46_RS05825	COG0583	DNA-binding transcription factor activity
GPY46_RS05870	COG3706	GGDEF domain
GPY46_RS05900	COG0579	oxidoreductase
GPY46_RS05910	COG3033	Beta-eliminating lyase
GPY46_RS05930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY46_RS05940	COG3145	DNA-N1-methyladenine dioxygenase activity
GPY46_RS05950	COG0840	transmembrane signaling receptor activity
GPY46_RS05965	COG3706	GGDEF domain
GPY46_RS05970	COG0415	Belongs to the DNA photolyase family
GPY46_RS05975	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY46_RS05990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY46_RS05990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY46_RS05995	COG1765	OsmC-like protein
GPY46_RS06000	COG0110	maltose O-acetyltransferase activity
GPY46_RS06040	COG1011	Hydrolase
GPY46_RS06055	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY46_RS06065	COG2067	long-chain fatty acid transport protein
GPY46_RS06070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY46_RS06075	COG1136	(ABC) transporter
GPY46_RS06075	COG0577	efflux transmembrane transporter activity
GPY46_RS06085	COG3240	lipase activity
GPY46_RS06115	COG1609	Transcriptional regulator
GPY46_RS06120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY46_RS06135	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY46_RS06145	COG3842	ATPase activity
GPY46_RS06170	COG2990	Protein conserved in bacteria
GPY46_RS06185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY46_RS06190	COG2866	Carboxypeptidase
GPY46_RS06205	COG0583	DNA-binding transcription factor activity
GPY46_RS06230	COG1760	l-serine dehydratase
GPY46_RS06250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY46_RS06260	COG0741	lytic transglycosylase activity
GPY46_RS06280	COG1815	bacterial-type flagellum-dependent cell motility
GPY46_RS06285	COG1558	bacterial-type flagellum-dependent cell motility
GPY46_RS06290	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY46_RS06295	COG1749	Flagellar hook protein flgE
GPY46_RS06300	COG4787	bacterial-type flagellum-dependent cell motility
GPY46_RS06305	COG4786	Flagellar basal body rod
GPY46_RS06310	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY46_RS06315	COG1706	bacterial-type flagellum-dependent cell motility
GPY46_RS06325	COG4786	Flagellar basal body rod
GPY46_RS06325	COG1256	bacterial-type flagellum assembly
GPY46_RS06330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY46_RS06350	COG1304	FMN binding
GPY46_RS06380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY46_RS06390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY46_RS06395	COG0459	protein refolding
GPY46_RS06410	COG1280	lysine exporter protein (LysE YggA)
GPY46_RS06430	COG1309	transcriptional regulator
GPY46_RS06440	COG0737	Belongs to the 5'-nucleotidase family
GPY46_RS06445	COG2070	2-Nitropropane dioxygenase
GPY46_RS06450	COG3537	Alpha-1,2-mannosidase
GPY46_RS06455	COG3537	Alpha-1,2-mannosidase
GPY46_RS06465	COG3537	Alpha-1,2-mannosidase
GPY46_RS06470	COG3537	Alpha-1,2-mannosidase
GPY46_RS06475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY46_RS06485	COG0583	DNA-binding transcription factor activity
GPY46_RS06500	COG0346	lactoylglutathione lyase activity
GPY46_RS06505	COG1349	DNA-binding transcription factor activity
GPY46_RS06515	COG0753	catalase activity
GPY46_RS06525	COG1335	isochorismatase
GPY46_RS06535	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY46_RS06565	COG0583	DNA-binding transcription factor activity
GPY46_RS06580	COG3713	MltA-interacting MipA family protein
GPY46_RS06590	COG3015	lipoprotein NlpE involved in copper resistance
GPY46_RS06600	COG1342	Belongs to the UPF0251 family
GPY46_RS06625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY46_RS06635	COG4948	Mandelate Racemase Muconate Lactonizing
GPY46_RS06645	COG0583	DNA-binding transcription factor activity
GPY46_RS06695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY46_RS06745	COG3842	ATPase activity
GPY46_RS06775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY46_RS06795	COG3706	GGDEF domain
GPY46_RS06815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY46_RS06830	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY46_RS06835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY46_RS06855	COG0574	Belongs to the PEP-utilizing enzyme family
GPY46_RS06855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY46_RS06860	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY46_RS06865	COG0252	asparaginase activity
GPY46_RS06875	COG0583	DNA-binding transcription factor activity
GPY46_RS06890	COG3122	Protein conserved in bacteria
GPY46_RS06905	COG1028	Short-chain dehydrogenase reductase Sdr
GPY46_RS06915	COG1063	alcohol dehydrogenase
GPY46_RS06920	COG1902	pentaerythritol trinitrate reductase activity
GPY46_RS06935	COG0583	DNA-binding transcription factor activity
GPY46_RS06945	COG0513	Belongs to the DEAD box helicase family
GPY46_RS06990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY46_RS06995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY46_RS06995	COG2207	Transcriptional regulator
GPY46_RS07015	COG3746	phosphate-selective porin O and P
GPY46_RS07035	COG1028	Short-chain dehydrogenase reductase Sdr
GPY46_RS07055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY46_RS07065	COG0625	glutathione transferase activity
GPY46_RS07075	COG1686	Belongs to the peptidase S11 family
GPY46_RS07095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY46_RS07115	COG1278	Cold shock
GPY46_RS07120	COG1741	Belongs to the pirin family
GPY46_RS07125	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY46_RS07135	COG1846	Transcriptional regulator
GPY46_RS07150	COG2814	Major facilitator Superfamily
GPY46_RS07160	COG0673	inositol 2-dehydrogenase activity
GPY46_RS07165	COG2194	sulfuric ester hydrolase activity
GPY46_RS07170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY46_RS07180	COG2205	protein histidine kinase activity
GPY46_RS07185	COG0745	RESPONSE REGULATOR receiver
GPY46_RS07190	COG4221	oxidoreductase activity
GPY46_RS07210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY46_RS07230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY46_RS07240	COG2814	Major facilitator Superfamily
GPY46_RS07255	COG1418	mRNA catabolic process
GPY46_RS07265	COG0402	S-adenosylhomocysteine deaminase activity
GPY46_RS07270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY46_RS07280	COG2239	Acts as a magnesium transporter
GPY46_RS07285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY46_RS07300	COG0531	amino acid
GPY46_RS07310	COG1522	sequence-specific DNA binding
GPY46_RS07340	COG2205	protein histidine kinase activity
GPY46_RS07340	COG0784	Response regulator, receiver
GPY46_RS07340	COG5002	protein histidine kinase activity
GPY46_RS07345	COG0673	inositol 2-dehydrogenase activity
GPY46_RS07350	COG0534	Mate efflux family protein
GPY46_RS07355	COG2926	Belongs to the UPF0265 family
GPY46_RS07370	COG3132	Protein of unknown function, DUF480
GPY46_RS07375	COG2827	Endonuclease containing a URI domain
GPY46_RS07380	COG1879	ABC-type sugar transport system periplasmic component
GPY46_RS07385	COG0784	Response regulator, receiver
GPY46_RS07385	COG2205	protein histidine kinase activity
GPY46_RS07395	COG1566	PFAM secretion protein HlyD family protein
GPY46_RS07415	COG1522	sequence-specific DNA binding
GPY46_RS07440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY46_RS07445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY46_RS07465	COG0183	Belongs to the thiolase family
GPY46_RS07475	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPY46_RS07485	COG3005	denitrification pathway
GPY46_RS07495	COG0243	molybdopterin cofactor binding
GPY46_RS07505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY46_RS07510	COG3850	Histidine kinase
GPY46_RS07515	COG2197	response regulator
GPY46_RS07530	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY46_RS07550	COG0840	transmembrane signaling receptor activity
GPY46_RS07560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY46_RS07570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY46_RS07575	COG2814	Major facilitator Superfamily
GPY46_RS07585	COG0840	transmembrane signaling receptor activity
GPY46_RS07590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY46_RS07595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY46_RS07620	COG2897	thiosulfate sulfurtransferase activity
GPY46_RS07640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY46_RS07650	COG0302	gtp cyclohydrolase
GPY46_RS07655	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY46_RS07665	COG0038	chloride channel
GPY46_RS07680	COG4989	oxidoreductase activity
GPY46_RS07695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY46_RS07695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY46_RS07700	COG0516	GMP reductase activity
GPY46_RS07705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY46_RS07775	COG3474	cytochrome
GPY46_RS07785	COG0789	Transcriptional regulator
GPY46_RS07790	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY46_RS07795	COG0384	phenazine biosynthesis protein PhzF
GPY46_RS07805	COG1294	oxidase, subunit
GPY46_RS07810	COG1271	oxidase subunit
GPY46_RS07815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY46_RS07820	COG0110	maltose O-acetyltransferase activity
GPY46_RS07830	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY46_RS07830	COG3264	Mechanosensitive ion channel
GPY46_RS07845	COG3437	response regulator, receiver
GPY46_RS07845	COG2205	protein histidine kinase activity
GPY46_RS07845	COG3850	Histidine kinase
GPY46_RS07845	COG4999	Histidine kinase
GPY46_RS07855	COG0439	Biotin carboxylase
GPY46_RS07865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY46_RS07870	COG1960	acyl-CoA dehydrogenase activity
GPY46_RS07880	COG0183	Belongs to the thiolase family
GPY46_RS07890	COG1960	acyl-CoA dehydrogenase activity
GPY46_RS07895	COG1024	Enoyl-CoA hydratase
GPY46_RS07920	COG3706	GGDEF domain
GPY46_RS07925	COG1309	transcriptional regulator
GPY46_RS07930	COG1012	belongs to the aldehyde dehydrogenase family
GPY46_RS07945	COG4176	ABC-type proline glycine betaine transport system permease component
GPY46_RS07950	COG4175	Glycine betaine
GPY46_RS07950	COG0517	IMP dehydrogenase activity
GPY46_RS07965	COG0330	HflC and HflK could
GPY46_RS07975	COG3300	MHYT domain
GPY46_RS07975	COG5001	Diguanylate cyclase
GPY46_RS07995	COG2205	protein histidine kinase activity
GPY46_RS07995	COG0784	Response regulator, receiver
GPY46_RS08055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY46_RS08060	COG5001	Diguanylate cyclase
GPY46_RS08065	COG1869	D-ribose catabolic process
GPY46_RS08070	COG1129	ABC transporter
GPY46_RS08075	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY46_RS08080	COG1879	ABC-type sugar transport system periplasmic component
GPY46_RS08085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY46_RS08090	COG1609	Transcriptional regulator
GPY46_RS08105	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY46_RS08115	COG4607	ABC-type enterochelin transport system periplasmic component
GPY46_RS08120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY46_RS08125	COG4605	iron ion homeostasis
GPY46_RS08130	COG4604	ABC transporter, ATP-binding protein
GPY46_RS08135	COG0789	Transcriptional regulator
GPY46_RS08150	COG4771	TonB-dependent receptor
GPY46_RS08150	COG1629	transport
GPY46_RS08185	COG1289	transmembrane transporter activity
GPY46_RS08190	COG0210	DNA helicase
GPY46_RS08195	COG1803	Methylglyoxal synthase
GPY46_RS08200	COG1879	ABC-type sugar transport system periplasmic component
GPY46_RS08205	COG0784	Response regulator, receiver
GPY46_RS08205	COG2205	protein histidine kinase activity
GPY46_RS08205	COG2198	Histidine kinase
GPY46_RS08220	COG0745	RESPONSE REGULATOR receiver
GPY46_RS08225	COG3119	arylsulfatase activity
GPY46_RS08230	COG3119	arylsulfatase activity
GPY46_RS08245	COG3119	arylsulfatase activity
GPY46_RS08250	COG0641	radical SAM
GPY46_RS08255	COG0714	Associated with various cellular activities
GPY46_RS08285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY46_RS08290	COG0583	DNA-binding transcription factor activity
GPY46_RS08295	COG1597	lipid kinase activity
GPY46_RS08300	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY46_RS08320	COG0641	radical SAM
GPY46_RS08350	COG0501	Belongs to the peptidase M48B family
GPY46_RS08355	COG1704	LemA family
GPY46_RS08360	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY46_RS08370	COG0456	acetyltransferase
GPY46_RS08370	COG1214	PFAM Peptidase M22, glycoprotease
GPY46_RS08390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY46_RS08410	COG2207	Transcriptional regulator
GPY46_RS08435	COG4964	Belongs to the GSP D family
GPY46_RS08495	COG0583	DNA-binding transcription factor activity
GPY46_RS08500	COG0583	DNA-binding transcription factor activity
GPY46_RS08515	COG5001	Diguanylate cyclase
GPY46_RS08515	COG3300	MHYT domain
GPY46_RS08520	COG2197	response regulator
GPY46_RS08525	COG3706	GGDEF domain
GPY46_RS08535	COG2197	response regulator
GPY46_RS08560	COG0835	chemotaxis
GPY46_RS08560	COG0784	Response regulator, receiver
GPY46_RS08580	COG2962	Rard protein
GPY46_RS08595	COG0671	phosphoesterase, PA-phosphatase related
GPY46_RS08610	COG2076	Multidrug Resistance protein
GPY46_RS08640	COG0471	metal ion transport
GPY46_RS08645	COG3290	protein histidine kinase activity
GPY46_RS08650	COG4565	transcriptional regulatory protein
GPY46_RS08660	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY46_RS08660	COG0069	glutamate synthase activity
GPY46_RS08670	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY46_RS08695	COG1902	pentaerythritol trinitrate reductase activity
GPY46_RS08700	COG0346	lactoylglutathione lyase activity
GPY46_RS08720	COG2239	Acts as a magnesium transporter
GPY46_RS08745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY46_RS08750	COG1739	Uncharacterized protein family UPF0029
GPY46_RS08755	COG1024	Enoyl-CoA hydratase
GPY46_RS08755	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY46_RS08760	COG0183	Belongs to the thiolase family
GPY46_RS08765	COG0604	alcohol dehydrogenase
GPY46_RS08780	COG0425	Belongs to the sulfur carrier protein TusA family
GPY46_RS08790	COG2119	membrane
GPY46_RS08795	COG0752	glycyl-tRNA synthetase alpha subunit
GPY46_RS08800	COG0751	glycine-tRNA ligase activity
GPY46_RS08805	COG0366	Alpha amylase catalytic
GPY46_RS08810	COG3977	Valine--pyruvate aminotransferase
GPY46_RS08815	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY46_RS08835	COG0187	DNA topoisomerase II activity
GPY46_RS08840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY46_RS08845	COG0592	DNA-directed DNA polymerase activity
GPY46_RS08850	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY46_RS08875	COG1126	abc transporter atp-binding protein
GPY46_RS08885	COG0594	ribonuclease P activity
GPY46_RS08890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY46_RS08895	COG0706	membrane insertase activity
GPY46_RS08900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY46_RS08905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY46_RS08910	COG0445	tRNA wobble uridine modification
GPY46_RS08915	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY46_RS08920	COG1192	Involved in chromosome partitioning
GPY46_RS08925	COG1475	DNA binding
GPY46_RS08930	COG3312	ion transport
GPY46_RS08935	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY46_RS08950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY46_RS08955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY46_RS08960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY46_RS08965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY46_RS08970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY46_RS08975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY46_RS08980	COG0765	amino acid transport
GPY46_RS08985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY46_RS08990	COG2814	Major facilitator Superfamily
GPY46_RS08995	COG0583	DNA-binding transcription factor activity
GPY46_RS09005	COG0129	dihydroxy-acid dehydratase activity
GPY46_RS09010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY46_RS09015	COG3978	acetolactate synthase activity
GPY46_RS09025	COG0606	chelatase, subunit chli
GPY46_RS09035	COG0204	Acyl-transferase
GPY46_RS09040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY46_RS09045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY46_RS09055	COG3084	Protein conserved in bacteria
GPY46_RS09065	COG4326	sporulation control protein
GPY46_RS09070	COG1272	protein, Hemolysin III
GPY46_RS09080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY46_RS09085	COG0569	domain protein
GPY46_RS09090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY46_RS09090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY46_RS09095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY46_RS09100	COG0242	peptide deformylase activity
GPY46_RS09110	COG0758	DNA mediated transformation
GPY46_RS09115	COG2922	Belongs to the Smg family
GPY46_RS09120	COG0551	DNA topoisomerase type I activity
GPY46_RS09125	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY46_RS09130	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY46_RS09135	COG0009	L-threonylcarbamoyladenylate synthase
GPY46_RS09140	COG0408	coproporphyrinogen oxidase activity
GPY46_RS09145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY46_RS09155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY46_RS09195	COG0583	DNA-binding transcription factor activity
GPY46_RS09200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY46_RS09205	COG2960	long-chain fatty acid transporting porin activity
GPY46_RS09215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY46_RS09220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY46_RS09285	COG4172	Belongs to the ABC transporter superfamily
GPY46_RS09290	COG0747	negative chemotaxis
GPY46_RS09300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY46_RS09340	COG1609	Transcriptional regulator
GPY46_RS09345	COG0583	DNA-binding transcription factor activity
GPY46_RS09355	COG2076	Multidrug Resistance protein
GPY46_RS09360	COG0129	dihydroxy-acid dehydratase activity
GPY46_RS09365	COG3265	gluconokinase activity
GPY46_RS09370	COG2610	gluconate transmembrane transporter activity
GPY46_RS09375	COG0800	Aldolase
GPY46_RS09380	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY46_RS09385	COG0583	DNA-binding transcription factor activity
GPY46_RS09390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY46_RS09395	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY46_RS09400	COG0339	signal peptide processing
GPY46_RS09405	COG1522	sequence-specific DNA binding
GPY46_RS09410	COG5002	protein histidine kinase activity
GPY46_RS09410	COG5001	Diguanylate cyclase
GPY46_RS09415	COG0742	ribosomal rna small subunit methyltransferase
GPY46_RS09425	COG0697	spore germination
GPY46_RS09430	COG0589	response to stress
GPY46_RS09435	COG1528	Iron-storage protein
GPY46_RS09445	COG2081	HI0933 family
GPY46_RS09455	COG2823	Periplasmic or secreted lipoprotein
GPY46_RS09505	COG0628	permease
GPY46_RS09520	COG1322	Protein conserved in bacteria
GPY46_RS09525	COG2226	methyltransferase
GPY46_RS09530	COG3165	ubiquinone biosynthetic process from chorismate
GPY46_RS09535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY46_RS09540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY46_RS09550	COG0805	protein transport
GPY46_RS09560	COG0084	hydrolase, TatD family'
GPY46_RS09585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY46_RS09585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY46_RS09595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY46_RS09630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY46_RS09635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY46_RS09645	COG2204	response regulator
GPY46_RS09650	COG3852	Histidine kinase
GPY46_RS09660	COG0174	glutamine synthetase
GPY46_RS09680	COG1295	ribonuclease BN
GPY46_RS09685	COG1490	D-aminoacyl-tRNA deacylase activity
GPY46_RS09690	COG0456	acetyltransferase
GPY46_RS09700	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY46_RS09705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY46_RS09710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY46_RS09715	COG3031	protein transport across the cell outer membrane
GPY46_RS09725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY46_RS09730	COG1459	type II secretion system
GPY46_RS09735	COG2165	general secretion pathway protein
GPY46_RS09740	COG2165	general secretion pathway protein
GPY46_RS09745	COG2165	general secretion pathway protein
GPY46_RS09750	COG4795	General secretion pathway protein
GPY46_RS09755	COG3156	type II secretion system protein K
GPY46_RS09760	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY46_RS09765	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY46_RS09775	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY46_RS09780	COG0494	nUDIX hydrolase
GPY46_RS09785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY46_RS09785	COG0316	Belongs to the HesB IscA family
GPY46_RS09790	COG1040	competence protein
GPY46_RS09795	COG0596	Alpha beta hydrolase
GPY46_RS09805	COG2183	response to ionizing radiation
GPY46_RS09815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY46_RS09825	COG0745	RESPONSE REGULATOR receiver
GPY46_RS09830	COG2205	protein histidine kinase activity
GPY46_RS09835	COG2233	PERMEase
GPY46_RS09840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY46_RS09845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY46_RS09850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY46_RS09855	COG1758	RNA polymerase activity
GPY46_RS09860	COG0194	GDP metabolic process
GPY46_RS09875	COG0848	biopolymer transport protein
GPY46_RS09880	COG0811	peptide transport
GPY46_RS09905	COG4174	ABC transporter (Permease)
GPY46_RS09910	COG4239	(ABC) transporter, permease
GPY46_RS09915	COG0747	negative chemotaxis
GPY46_RS09920	COG0444	Belongs to the ABC transporter superfamily
GPY46_RS09925	COG4608	Belongs to the ABC transporter superfamily
GPY46_RS09935	COG1561	YicC-like family, N-terminal region
GPY46_RS09940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY46_RS09945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY46_RS09950	COG1560	Kdo2-lipid A biosynthetic process
GPY46_RS09955	COG1309	transcriptional regulator
GPY46_RS09960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY46_RS09975	COG2003	Belongs to the UPF0758 family
GPY46_RS09980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY46_RS09995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY46_RS10000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY46_RS10015	COG0463	Glycosyl transferase, family 2
GPY46_RS10020	COG0859	PFAM glycosyl transferase family 9
GPY46_RS10025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY46_RS10030	COG3642	lipopolysaccharide core region biosynthetic process
GPY46_RS10040	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPY46_RS10080	COG1519	Transferase
GPY46_RS10085	COG0859	PFAM glycosyl transferase family 9
GPY46_RS10095	COG1560	Kdo2-lipid A biosynthetic process
GPY46_RS10105	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY46_RS10155	COG0438	transferase activity, transferring glycosyl groups
GPY46_RS10165	COG0438	transferase activity, transferring glycosyl groups
GPY46_RS10165	COG0297	glycogen (starch) synthase activity
GPY46_RS10175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY46_RS10185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY46_RS10210	COG0463	Glycosyl transferase, family 2
GPY46_RS10270	COG0149	triose-phosphate isomerase activity
GPY46_RS10295	COG1494	fructose-1,6-bisphosphatase
GPY46_RS10305	COG3074	FtsZ-dependent cytokinesis
GPY46_RS10310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY46_RS10315	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY46_RS10320	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY46_RS10325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY46_RS10335	COG1609	Transcriptional regulator
GPY46_RS10340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY46_RS10350	COG0254	rRNA binding
GPY46_RS10360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY46_RS10365	COG0088	Forms part of the polypeptide exit tunnel
GPY46_RS10375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY46_RS10380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY46_RS10385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY46_RS10390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY46_RS10400	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY46_RS10405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY46_RS10410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY46_RS10415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY46_RS10420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY46_RS10425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY46_RS10430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY46_RS10435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY46_RS10450	COG1841	ribosomal large subunit assembly
GPY46_RS10455	COG0200	Binds to the 23S rRNA
GPY46_RS10460	COG0201	protein transport
GPY46_RS10470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY46_RS10475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY46_RS10485	COG0202	RNA polymerase activity
GPY46_RS10490	COG0203	ribosomal protein L17
GPY46_RS10500	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY46_RS10510	COG2153	protein acetylation
GPY46_RS10515	COG0513	Belongs to the DEAD box helicase family
GPY46_RS10525	COG0737	Belongs to the 5'-nucleotidase family
GPY46_RS10530	COG1648	precorrin-2 dehydrogenase activity
GPY46_RS10530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY46_RS10535	COG0175	sulfate reduction
GPY46_RS10540	COG2895	sulfate adenylyltransferase (ATP) activity
GPY46_RS10550	COG0471	metal ion transport
GPY46_RS10550	COG3273	potassium ion transport
GPY46_RS10555	COG0529	Catalyzes the synthesis of activated sulfate
GPY46_RS10575	COG4181	ATPase activity
GPY46_RS10590	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY46_RS10600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY46_RS10605	COG0729	surface antigen
GPY46_RS10615	COG2105	PFAM AIG2 family protein
GPY46_RS10625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY46_RS10630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY46_RS10640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY46_RS10645	COG0163	prenyltransferase activity
GPY46_RS10650	COG4143	(ABC) transporter
GPY46_RS10655	COG1178	ABC-type Fe3 transport system permease component
GPY46_RS10660	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY46_RS10695	COG0039	L-malate dehydrogenase activity
GPY46_RS10705	COG0142	geranyltranstransferase activity
GPY46_RS10710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY46_RS10720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY46_RS10725	COG2966	Psort location CytoplasmicMembrane, score
GPY46_RS10740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY46_RS10745	COG2967	ApaG domain
GPY46_RS10750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY46_RS10755	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY46_RS10760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY46_RS10765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY46_RS10770	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY46_RS10780	COG0066	3-isopropylmalate dehydratase activity
GPY46_RS10785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY46_RS10790	COG0473	3-isopropylmalate dehydrogenase activity
GPY46_RS10795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY46_RS10820	COG0583	DNA-binding transcription factor activity
GPY46_RS10825	COG1022	Amp-dependent synthetase and ligase
GPY46_RS10830	COG0028	Belongs to the TPP enzyme family
GPY46_RS10835	COG0440	acetolactate synthase activity
GPY46_RS10840	COG3706	GGDEF domain
GPY46_RS10850	COG0469	pyruvate kinase activity
GPY46_RS10860	COG1349	DNA-binding transcription factor activity
GPY46_RS10865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY46_RS10880	COG5002	protein histidine kinase activity
GPY46_RS10885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY46_RS10890	COG3722	fumarate hydratase activity
GPY46_RS10895	COG0246	Mannitol dehydrogenase
GPY46_RS10900	COG2213	PTS system mannitol-specific
GPY46_RS10900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY46_RS10935	COG2207	Transcriptional regulator
GPY46_RS10945	COG1464	Belongs to the NlpA lipoprotein family
GPY46_RS10995	COG2003	Belongs to the UPF0758 family
GPY46_RS11010	COG3339	Conserved Protein
GPY46_RS11050	COG0582	viral genome integration into host DNA
GPY46_RS11060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY46_RS11065	COG0358	DNA primase activity
GPY46_RS11070	COG1610	YqeY-like protein
GPY46_RS11075	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY46_RS11080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY46_RS11085	COG0596	Alpha beta hydrolase
GPY46_RS11090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY46_RS11095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY46_RS11100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY46_RS11105	COG1968	undecaprenyl-diphosphatase activity
GPY46_RS11110	COG0617	tRNA 3'-terminal CCA addition
GPY46_RS11115	COG3267	Type II secretory pathway component ExeA
GPY46_RS11115	COG3409	Peptidoglycan-binding domain 1 protein
GPY46_RS11125	COG4991	sh3 domain protein
GPY46_RS11130	COG0306	phosphate transporter
GPY46_RS11135	COG1392	Phosphate transport regulator
GPY46_RS11140	COG3025	triphosphatase activity
GPY46_RS11155	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY46_RS11160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY46_RS11160	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY46_RS11165	COG1538	Outer membrane efflux protein
GPY46_RS11170	COG0494	nUDIX hydrolase
GPY46_RS11175	COG3151	Protein conserved in bacteria
GPY46_RS11185	COG3150	esterase
GPY46_RS11190	COG0187	DNA topoisomerase II activity
GPY46_RS11195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY46_RS11200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY46_RS11210	COG3105	Protein conserved in bacteria
GPY46_RS11220	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY46_RS11230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY46_RS11235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY46_RS11240	COG0723	plastoquinol--plastocyanin reductase activity
GPY46_RS11245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY46_RS11250	COG2857	Cytochrome c1
GPY46_RS11255	COG0625	glutathione transferase activity
GPY46_RS11260	COG2969	positive regulation of protein catabolic process
GPY46_RS11265	COG2823	Periplasmic or secreted lipoprotein
GPY46_RS11270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY46_RS11275	COG0792	nuclease activity
GPY46_RS11285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY46_RS11300	COG0275	rRNA processing
GPY46_RS11305	COG3116	cell division
GPY46_RS11310	COG0768	penicillin binding
GPY46_RS11315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY46_RS11320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY46_RS11325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY46_RS11330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY46_RS11335	COG0772	Belongs to the SEDS family
GPY46_RS11340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY46_RS11345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY46_RS11350	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY46_RS11355	COG0849	cell division
GPY46_RS11360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY46_RS11365	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY46_RS11375	COG0653	protein targeting
GPY46_RS11380	COG0494	nUDIX hydrolase
GPY46_RS11385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY46_RS11390	COG0505	Belongs to the CarA family
GPY46_RS11395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY46_RS11410	COG0730	response to heat
GPY46_RS11415	COG0583	DNA-binding transcription factor activity
GPY46_RS11420	COG2860	membrane
GPY46_RS11425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY46_RS11435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY46_RS11445	COG0493	'glutamate synthase
GPY46_RS11450	COG0069	glutamate synthase activity
GPY46_RS11450	COG0070	glutamate synthase
GPY46_RS11450	COG0067	glutamate synthase
GPY46_RS11460	COG0070	glutamate synthase
GPY46_RS11460	COG0069	glutamate synthase activity
GPY46_RS11460	COG0067	glutamate synthase
GPY46_RS11465	COG1242	4 iron, 4 sulfur cluster binding
GPY46_RS11470	COG3706	GGDEF domain
GPY46_RS11470	COG5001	Diguanylate cyclase
GPY46_RS11470	COG4251	negative regulation of phosphorylation
GPY46_RS11470	COG2203	Gaf domain
GPY46_RS11475	COG5002	protein histidine kinase activity
GPY46_RS11475	COG0784	Response regulator, receiver
GPY46_RS11475	COG2198	Histidine kinase
GPY46_RS11485	COG0745	RESPONSE REGULATOR receiver
GPY46_RS11500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY46_RS11515	COG0083	homoserine kinase activity
GPY46_RS11520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY46_RS11525	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY46_RS11530	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY46_RS11540	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY46_RS11555	COG1115	amino acid carrier protein
GPY46_RS11560	COG3022	response to hydroperoxide
GPY46_RS11565	COG0513	Belongs to the DEAD box helicase family
GPY46_RS11570	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY46_RS11580	COG0716	FMN binding
GPY46_RS11590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY46_RS11595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY46_RS11610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY46_RS11625	COG0667	Aldo Keto reductase
GPY46_RS11635	COG3066	DNA modification
GPY46_RS11645	COG0494	nUDIX hydrolase
GPY46_RS11655	COG0730	response to heat
GPY46_RS11660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY46_RS11665	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY46_RS11675	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY46_RS11680	COG0583	DNA-binding transcription factor activity
GPY46_RS11690	COG0640	Transcriptional regulator
GPY46_RS11700	COG0268	Binds directly to 16S ribosomal RNA
GPY46_RS11705	COG0728	peptidoglycan biosynthetic process
GPY46_RS11710	COG0196	riboflavin kinase activity
GPY46_RS11715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY46_RS11720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY46_RS11725	COG1047	Peptidyl-prolyl cis-trans
GPY46_RS11730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY46_RS11735	COG3279	Response regulator of the LytR AlgR family
GPY46_RS11740	COG3275	phosphorelay sensor kinase activity
GPY46_RS11745	COG1966	Carbon starvation protein
GPY46_RS11760	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY46_RS11765	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY46_RS11770	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY46_RS11775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY46_RS11780	COG1605	Chorismate mutase
GPY46_RS11780	COG0287	Prephenate dehydrogenase
GPY46_RS11785	COG0739	heme binding
GPY46_RS11800	COG0488	(ABC) transporter
GPY46_RS11810	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY46_RS11815	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY46_RS11820	COG1605	Chorismate mutase
GPY46_RS11820	COG0077	Prephenate dehydratase
GPY46_RS11825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY46_RS11830	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY46_RS11835	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY46_RS11840	COG0564	pseudouridine synthase activity
GPY46_RS11850	COG0542	response to heat
GPY46_RS11915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY46_RS11925	COG2974	May be involved in recombination
GPY46_RS11930	COG0745	RESPONSE REGULATOR receiver
GPY46_RS11935	COG5002	protein histidine kinase activity
GPY46_RS11945	COG0248	Ppx GppA phosphatase
GPY46_RS11950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY46_RS11960	COG0581	inorganic phosphate transmembrane transporter activity
GPY46_RS11965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY46_RS11970	COG0704	Plays a role in the regulation of phosphate uptake
GPY46_RS11980	COG3142	Participates in the control of copper homeostasis
GPY46_RS11985	COG0450	alkyl hydroperoxide reductase
GPY46_RS11990	COG0583	DNA-binding transcription factor activity
GPY46_RS12000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY46_RS12010	COG0517	IMP dehydrogenase activity
GPY46_RS12020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY46_RS12025	COG0343	queuine tRNA-ribosyltransferase activity
GPY46_RS12030	COG1862	Preprotein translocase
GPY46_RS12035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY46_RS12040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY46_RS12050	COG0483	inositol monophosphate 1-phosphatase activity
GPY46_RS12065	COG1104	cysteine desulfurase activity
GPY46_RS12070	COG0822	iron-sulfur transferase activity
GPY46_RS12080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY46_RS12085	COG0443	Heat shock 70 kDa protein
GPY46_RS12090	COG0633	Ferredoxin
GPY46_RS12095	COG2975	iron-sulfur cluster assembly
GPY46_RS12100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY46_RS12105	COG0105	UTP biosynthetic process
GPY46_RS12110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY46_RS12125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY46_RS12130	COG0124	histidyl-tRNA synthetase
GPY46_RS12135	COG2976	Protein conserved in bacteria
GPY46_RS12140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY46_RS12145	COG1160	GTP binding
GPY46_RS12160	COG1570	exodeoxyribonuclease VII activity
GPY46_RS12165	COG0516	GMP reductase activity
GPY46_RS12165	COG0517	IMP dehydrogenase activity
GPY46_RS12170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY46_RS12170	COG0519	Catalyzes the synthesis of GMP from XMP
GPY46_RS12175	COG1757	Na H antiporter
GPY46_RS12185	COG1584	GPR1 FUN34 yaaH family protein
GPY46_RS12195	COG1115	amino acid carrier protein
GPY46_RS12230	COG2873	o-acetylhomoserine
GPY46_RS12235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY46_RS12255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY46_RS12255	COG3153	acetyltransferase
GPY46_RS12260	COG0583	DNA-binding transcription factor activity
GPY46_RS12280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY46_RS12285	COG2867	negative regulation of translational initiation
GPY46_RS12290	COG2914	Belongs to the UPF0125 (RnfH) family
GPY46_RS12295	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY46_RS12300	COG0497	DNA recombination
GPY46_RS12310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY46_RS12315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY46_RS12325	COG0443	Heat shock 70 kDa protein
GPY46_RS12330	COG0484	heat shock protein binding
GPY46_RS12365	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY46_RS12370	COG0590	tRNA wobble adenosine to inosine editing
GPY46_RS12380	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY46_RS12385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY46_RS12385	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY46_RS12410	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY46_RS12415	COG2252	PERMEase
GPY46_RS12420	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY46_RS12435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY46_RS12440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY46_RS12445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY46_RS12450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY46_RS12450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY46_RS12470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY46_RS12475	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY46_RS12480	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY46_RS12485	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY46_RS12490	COG0142	geranyltranstransferase activity
GPY46_RS12495	COG1722	exodeoxyribonuclease VII activity
GPY46_RS12500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY46_RS12505	COG2885	chlorophyll binding
GPY46_RS12510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY46_RS12510	COG0301	tRNA thio-modification
GPY46_RS12515	COG0583	DNA-binding transcription factor activity
GPY46_RS12525	COG2363	Small membrane protein
GPY46_RS12530	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GPY46_RS12540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY46_RS12545	COG1611	Belongs to the LOG family
GPY46_RS12550	COG0745	RESPONSE REGULATOR receiver
GPY46_RS12550	COG3706	GGDEF domain
GPY46_RS12560	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY46_RS12560	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY46_RS12570	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY46_RS12575	COG1464	Belongs to the NlpA lipoprotein family
GPY46_RS12580	COG2011	ABC-type metal ion transport system permease component
GPY46_RS12585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY46_RS12595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY46_RS12605	COG1263	PTS System
GPY46_RS12605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY46_RS12610	COG0366	Alpha amylase catalytic
GPY46_RS12625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY46_RS12630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY46_RS12635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY46_RS12640	COG0321	lipoyl(octanoyl) transferase activity
GPY46_RS12645	COG2921	Belongs to the UPF0250 family
GPY46_RS12650	COG1686	Belongs to the peptidase S11 family
GPY46_RS12655	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY46_RS12660	COG0772	Belongs to the SEDS family
GPY46_RS12665	COG0768	penicillin binding
GPY46_RS12670	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY46_RS12675	COG0799	negative regulation of ribosome biogenesis
GPY46_RS12680	COG1466	dna polymerase III delta subunit
GPY46_RS12685	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY46_RS12690	COG0495	leucyl-tRNA aminoacylation
GPY46_RS12695	COG2888	peptidyl-tyrosine sulfation
GPY46_RS12700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY46_RS12705	COG4535	Mg2 and Co2 transporter CorC
GPY46_RS12710	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY46_RS12715	COG1702	phosphate starvation-inducible protein PhoH
GPY46_RS12720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY46_RS12730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY46_RS12845	COG0012	GTP binding
GPY46_RS12850	COG0193	aminoacyl-tRNA hydrolase activity
GPY46_RS12855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY46_RS12860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY46_RS12865	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY46_RS12870	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY46_RS12875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY46_RS12880	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY46_RS12885	COG3094	Invasion gene expression up-regulator, SirB
GPY46_RS12890	COG2912	Transglutaminase-like superfamily
GPY46_RS12895	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY46_RS12900	COG0737	Belongs to the 5'-nucleotidase family
GPY46_RS12910	COG1187	pseudouridine synthase activity
GPY46_RS12915	COG2840	Smr protein MutS2
GPY46_RS12955	COG2217	Heavy metal translocating P-type atpase
GPY46_RS12955	COG2608	mercury ion transmembrane transporter activity
GPY46_RS12970	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY46_RS12975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY46_RS13035	COG0784	Response regulator, receiver
GPY46_RS13035	COG0835	chemotaxis
GPY46_RS13040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY46_RS13045	COG1815	bacterial-type flagellum-dependent cell motility
GPY46_RS13050	COG1558	bacterial-type flagellum-dependent cell motility
GPY46_RS13055	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY46_RS13060	COG1749	Flagellar hook protein flgE
GPY46_RS13070	COG4787	bacterial-type flagellum-dependent cell motility
GPY46_RS13075	COG4786	Flagellar basal body rod
GPY46_RS13080	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY46_RS13085	COG1706	bacterial-type flagellum-dependent cell motility
GPY46_RS13090	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY46_RS13090	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY46_RS13100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY46_RS13110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY46_RS13120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY46_RS13125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY46_RS13135	COG2190	(PTS) system
GPY46_RS13140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY46_RS13145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY46_RS13155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY46_RS13160	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY46_RS13165	COG3115	cell septum assembly
GPY46_RS13170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY46_RS13195	COG0330	HflC and HflK could
GPY46_RS13200	COG3118	belongs to the thioredoxin family
GPY46_RS13210	COG0300	oxidoreductase activity
GPY46_RS13215	COG1090	epimerase
GPY46_RS13245	COG0622	Phosphoesterase
GPY46_RS13265	COG3710	Transcriptional regulator
GPY46_RS13270	COG0326	Molecular chaperone. Has ATPase activity
GPY46_RS13275	COG0563	adenylate kinase activity
GPY46_RS13280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY46_RS13285	COG3104	oligopeptide transport
GPY46_RS13290	COG0250	Participates in transcription elongation, termination and antitermination
GPY46_RS13295	COG0367	asparagine synthase
GPY46_RS13300	COG4651	solute:proton antiporter activity
GPY46_RS13300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY46_RS13305	COG1846	Transcriptional regulator
GPY46_RS13305	COG1940	carbohydrate kinase activity
GPY46_RS13310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY46_RS13320	COG2190	(PTS) system
GPY46_RS13320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY46_RS13320	COG1263	PTS System
GPY46_RS13325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY46_RS13330	COG0735	belongs to the Fur family
GPY46_RS13340	COG0716	FMN binding
GPY46_RS13350	COG0596	Alpha beta hydrolase
GPY46_RS13355	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY46_RS13360	COG0033	Phosphoglucomutase
GPY46_RS13370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY46_RS13380	COG2009	succinate dehydrogenase
GPY46_RS13385	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY46_RS13390	COG1053	succinate dehydrogenase
GPY46_RS13395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY46_RS13400	COG0567	Dehydrogenase, E1 component
GPY46_RS13405	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY46_RS13410	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY46_RS13420	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY46_RS13425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY46_RS13430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY46_RS13435	COG2233	PERMEase
GPY46_RS13455	COG4783	chaperone-mediated protein folding
GPY46_RS13470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY46_RS13475	COG2716	regulation of RNA biosynthetic process
GPY46_RS13480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY46_RS13500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY46_RS13505	COG1393	Belongs to the ArsC family
GPY46_RS13535	COG2837	iron assimilation
GPY46_RS13540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY46_RS13550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY46_RS13555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY46_RS13560	COG1334	flagellar protein FlaG
GPY46_RS13565	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY46_RS13575	COG1516	flagellar protein fliS
GPY46_RS13585	COG4191	Histidine kinase
GPY46_RS13590	COG2204	response regulator
GPY46_RS13595	COG1677	Flagellar hook-basal body complex protein FliE
GPY46_RS13605	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY46_RS13655	COG1987	bacterial-type flagellum assembly
GPY46_RS13660	COG1684	flagellar biosynthetic protein fliR
GPY46_RS13680	COG0455	bacterial-type flagellum organization
GPY46_RS13695	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY46_RS13700	COG0643	Histidine kinase
GPY46_RS13700	COG2198	Histidine kinase
GPY46_RS13705	COG2201	protein-glutamate methylesterase activity
GPY46_RS13710	COG1192	Involved in chromosome partitioning
GPY46_RS13720	COG0835	chemotaxis
GPY46_RS13730	COG4133	protoheme IX ABC transporter activity
GPY46_RS13735	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY46_RS13740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY46_RS13745	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY46_RS13750	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY46_RS13755	COG1138	Cytochrome C-type biogenesis protein
GPY46_RS13760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY46_RS13775	COG2853	Lipoprotein
GPY46_RS13785	COG2067	long-chain fatty acid transport protein
GPY46_RS13800	COG0183	Belongs to the thiolase family
GPY46_RS13805	COG1024	Enoyl-CoA hydratase
GPY46_RS13805	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY46_RS13820	COG2062	phosphohistidine phosphatase, SixA
GPY46_RS13825	COG2840	Smr protein MutS2
GPY46_RS13830	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY46_RS13835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY46_RS13840	COG2860	membrane
GPY46_RS13850	COG3101	peptidyl-lysine hydroxylation
GPY46_RS13865	COG0431	NADPH-dependent FMN reductase
GPY46_RS13870	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY46_RS13870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY46_RS13875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY46_RS13880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY46_RS13885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY46_RS13895	COG0101	tRNA pseudouridine synthase activity
GPY46_RS13900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY46_RS13905	COG0285	dihydrofolate synthase activity
GPY46_RS13910	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY46_RS13915	COG1286	toxin biosynthetic process
GPY46_RS13920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY46_RS13925	COG0583	DNA-binding transcription factor activity
GPY46_RS13930	COG0745	RESPONSE REGULATOR receiver
GPY46_RS13940	COG2832	Protein of unknown function (DUF454)
GPY46_RS13945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY46_RS13955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY46_RS13960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY46_RS13965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY46_RS13970	COG0814	amino acid
GPY46_RS13975	COG0251	oxidation-reduction process
GPY46_RS13980	COG3681	Belongs to the UPF0597 family
GPY46_RS13995	COG2261	transglycosylase associated protein
GPY46_RS14000	COG2983	Belongs to the UPF0260 family
GPY46_RS14005	COG0668	transmembrane transport
GPY46_RS14010	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY46_RS14015	COG0346	lactoylglutathione lyase activity
GPY46_RS14025	COG1785	Belongs to the alkaline phosphatase family
GPY46_RS14045	COG2226	methyltransferase
GPY46_RS14060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY46_RS14065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY46_RS14075	COG3139	Protein of unknown function (DUF1315)
GPY46_RS14080	COG0252	asparaginase activity
GPY46_RS14085	COG0616	signal peptide processing
GPY46_RS14090	COG1902	pentaerythritol trinitrate reductase activity
GPY46_RS14090	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY46_RS14095	COG0778	Nitroreductase
GPY46_RS14100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY46_RS14120	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY46_RS14130	COG3083	sulfuric ester hydrolase activity
GPY46_RS14135	COG3082	Protein of unknown function (DUF1414)
GPY46_RS14140	COG3081	Nucleoid-associated protein
GPY46_RS14155	COG1757	Na H antiporter
GPY46_RS14160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY46_RS14165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY46_RS14170	COG2095	MarC family integral membrane protein
GPY46_RS14175	COG1012	belongs to the aldehyde dehydrogenase family
GPY46_RS14175	COG1454	alcohol dehydrogenase
GPY46_RS14195	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY46_RS14205	COG2056	Na+-H+ antiporter family
GPY46_RS14210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY46_RS14225	COG2885	chlorophyll binding
GPY46_RS14235	COG0346	lactoylglutathione lyase activity
GPY46_RS14240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY46_RS14245	COG4660	Part of a membrane complex involved in electron transport
GPY46_RS14250	COG4659	FMN binding
GPY46_RS14255	COG4658	electron transport chain
GPY46_RS14260	COG4656	Part of a membrane complex involved in electron transport
GPY46_RS14265	COG2878	Part of a membrane complex involved in electron transport
GPY46_RS14270	COG4657	Part of a membrane complex involved in electron transport
GPY46_RS14285	COG0556	nucleotide-excision repair
GPY46_RS14290	COG2204	response regulator
GPY46_RS14295	COG2198	Histidine kinase
GPY46_RS14300	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY46_RS14305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY46_RS14310	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY46_RS14315	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY46_RS14320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY46_RS14325	COG0314	molybdopterin synthase activity
GPY46_RS14335	COG0601	transmembrane transport
GPY46_RS14340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY46_RS14345	COG0444	Belongs to the ABC transporter superfamily
GPY46_RS14355	COG0435	Glutathione S-transferase
GPY46_RS14365	COG3174	membrane
GPY46_RS14370	COG0857	belongs to the CobB CobQ family
GPY46_RS14370	COG0280	phosphate acetyltransferase
GPY46_RS14375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY46_RS14380	COG3092	negative regulation of chromosome organization
GPY46_RS14390	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY46_RS14395	COG1122	ATPase activity
GPY46_RS14400	COG0366	Alpha amylase catalytic
GPY46_RS14405	COG3706	GGDEF domain
GPY46_RS14405	COG0745	RESPONSE REGULATOR receiver
GPY46_RS14410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY46_RS14415	COG3318	Belongs to the UPF0149 family
GPY46_RS14415	COG3012	SEC-C Motif Domain Protein
GPY46_RS14420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY46_RS14425	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY46_RS14430	COG2186	Transcriptional regulator
GPY46_RS14440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY46_RS14440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY46_RS14445	COG0489	protein tyrosine kinase activity
GPY46_RS14450	COG0572	uridine kinase
GPY46_RS14460	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY46_RS14465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY46_RS14470	COG0659	secondary active sulfate transmembrane transporter activity
GPY46_RS14475	COG1530	ribonuclease E activity
GPY46_RS14480	COG0564	pseudouridine synthase activity
GPY46_RS14485	COG0424	maF-like protein
GPY46_RS14490	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY46_RS14500	COG0416	fatty acid biosynthetic process
GPY46_RS14505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY46_RS14535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY46_RS14540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY46_RS14550	COG0084	hydrolase, TatD family'
GPY46_RS14555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY46_RS14555	COG1263	PTS System
GPY46_RS14575	COG0733	neurotransmitter:sodium symporter activity
GPY46_RS14590	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY46_RS14595	COG0469	pyruvate kinase activity
GPY46_RS14600	COG1940	carbohydrate kinase activity
GPY46_RS14605	COG0784	Response regulator, receiver
GPY46_RS14605	COG0835	chemotaxis
GPY46_RS14610	COG0587	DNA-directed DNA polymerase activity
GPY46_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
GPY46_RS14630	COG0616	signal peptide processing
GPY46_RS14635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY46_RS14640	COG0539	negative regulation of cytoplasmic translation
GPY46_RS14650	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY46_RS14655	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY46_RS14660	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY46_RS14665	COG4166	transmembrane transport
GPY46_RS14690	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY46_RS14700	COG3008	intermembrane lipid transfer
GPY46_RS14700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY46_RS14705	COG2995	paraquat-inducible protein a
GPY46_RS14710	COG3258	Cytochrome c
GPY46_RS14715	COG2863	cytochrome
GPY46_RS14755	COG4232	protein-disulfide reductase activity
GPY46_RS14760	COG3118	belongs to the thioredoxin family
GPY46_RS14790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY46_RS14800	COG1136	(ABC) transporter
GPY46_RS14800	COG0577	efflux transmembrane transporter activity
GPY46_RS14805	COG0577	efflux transmembrane transporter activity
GPY46_RS14805	COG1136	(ABC) transporter
GPY46_RS14810	COG0577	efflux transmembrane transporter activity
GPY46_RS14810	COG1136	(ABC) transporter
GPY46_RS14815	COG1335	isochorismatase
GPY46_RS14830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY46_RS14865	COG3850	Histidine kinase
GPY46_RS14865	COG5002	protein histidine kinase activity
GPY46_RS14870	COG0745	RESPONSE REGULATOR receiver
GPY46_RS14880	COG0840	transmembrane signaling receptor activity
GPY46_RS14885	COG1032	radical SAM domain protein
GPY46_RS14890	COG5001	Diguanylate cyclase
GPY46_RS14890	COG4251	negative regulation of phosphorylation
GPY46_RS14890	COG2203	Gaf domain
GPY46_RS14890	COG3706	GGDEF domain
GPY46_RS14905	COG0583	DNA-binding transcription factor activity
GPY46_RS14915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY46_RS14925	COG2350	Protein conserved in bacteria
GPY46_RS14930	COG1607	acyl-coa hydrolase
GPY46_RS14935	COG2917	probably involved in intracellular septation
GPY46_RS14955	COG1301	dicarboxylic acid transport
GPY46_RS14965	COG0318	PFAM AMP-dependent synthetase and ligase
GPY46_RS14970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY46_RS14975	COG0159	tryptophan synthase activity
GPY46_RS14980	COG0133	tryptophan synthase activity
GPY46_RS14985	COG0135	phosphoribosylanthranilate isomerase activity
GPY46_RS14985	COG0134	indole-3-glycerol-phosphate synthase activity
GPY46_RS14990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY46_RS14995	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY46_RS15000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY46_RS15010	COG0613	PHP domain protein
GPY46_RS15015	COG0009	L-threonylcarbamoyladenylate synthase
GPY46_RS15025	COG1187	pseudouridine synthase activity
GPY46_RS15035	COG3099	Belongs to the UPF0263 family
GPY46_RS15040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY46_RS15050	COG0417	DNA replication proofreading
GPY46_RS15055	COG2197	response regulator
GPY46_RS15060	COG0322	excinuclease ABC activity
GPY46_RS15100	COG0019	diaminopimelate decarboxylase activity
GPY46_RS15125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY46_RS15130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY46_RS15135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY46_RS15155	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY46_RS15165	COG0437	4 iron, 4 sulfur cluster binding
GPY46_RS15170	COG3301	Polysulphide reductase, NrfD
GPY46_RS15175	COG1138	Cytochrome C-type biogenesis protein
GPY46_RS15185	COG3088	subunit of a heme lyase
GPY46_RS15185	COG4235	cytochrome complex assembly
GPY46_RS15195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY46_RS15220	COG2989	Protein conserved in bacteria
GPY46_RS15225	COG3108	Peptidase M15
GPY46_RS15230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY46_RS15245	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY46_RS15270	COG1846	Transcriptional regulator
GPY46_RS15275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY46_RS15280	COG0840	transmembrane signaling receptor activity
GPY46_RS15300	COG1448	Aminotransferase
GPY46_RS15325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY46_RS15335	COG0017	Asparaginyl-tRNA synthetase
GPY46_RS15345	COG0720	synthase
GPY46_RS15355	COG2200	EAL domain
GPY46_RS15360	COG1760	l-serine dehydratase
GPY46_RS15365	COG0814	amino acid
GPY46_RS15370	COG0494	nUDIX hydrolase
GPY46_RS15380	COG0784	Response regulator, receiver
GPY46_RS15380	COG2205	protein histidine kinase activity
GPY46_RS15385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY46_RS15405	COG3106	COG3106 Predicted ATPase
GPY46_RS15410	COG3768	UPF0283 membrane protein
GPY46_RS15420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY46_RS15575	COG0456	acetyltransferase
GPY46_RS15705	COG1280	lysine exporter protein (LysE YggA)
GPY46_RS15970	COG2963	transposase activity
GPY46_RS15975	COG2801	Transposase and inactivated derivatives
GPY46_RS16155	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY46_RS16160	COG0583	DNA-binding transcription factor activity
GPY46_RS16195	COG0471	metal ion transport
GPY46_RS16200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY46_RS16200	COG4191	Histidine kinase
GPY46_RS16210	COG3300	MHYT domain
GPY46_RS16210	COG5001	Diguanylate cyclase
GPY46_RS16220	COG1280	lysine exporter protein (LysE YggA)
GPY46_RS16225	COG1328	CTP reductase activity
GPY46_RS16230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY46_RS16240	COG0861	Integral membrane protein TerC family
GPY46_RS16250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY46_RS16265	COG0814	amino acid
GPY46_RS16290	COG1132	(ABC) transporter
GPY46_RS16295	COG1132	(ABC) transporter
GPY46_RS16325	COG0443	Heat shock 70 kDa protein
GPY46_RS16330	COG0443	Heat shock 70 kDa protein
GPY46_RS16340	COG3706	GGDEF domain
GPY46_RS16370	COG0243	molybdopterin cofactor binding
GPY46_RS16375	COG0437	4 iron, 4 sulfur cluster binding
GPY46_RS16380	COG3302	dmso reductase anchor subunit
GPY46_RS16395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY46_RS16400	COG1643	Atp-dependent helicase
GPY46_RS16415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY46_RS16425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY46_RS16430	COG1215	transferase activity, transferring glycosyl groups
GPY46_RS16435	COG0438	transferase activity, transferring glycosyl groups
GPY46_RS16480	COG2204	response regulator
GPY46_RS16515	COG1793	dna ligase
GPY46_RS16525	COG0534	Mate efflux family protein
GPY46_RS16530	COG0307	riboflavin synthase, alpha
GPY46_RS16545	COG2201	protein-glutamate methylesterase activity
GPY46_RS16550	COG3706	GGDEF domain
GPY46_RS16560	COG0791	NLP P60 protein
GPY46_RS16565	COG0840	transmembrane signaling receptor activity
GPY46_RS16565	COG3290	protein histidine kinase activity
GPY46_RS16605	COG1940	carbohydrate kinase activity
GPY46_RS16620	COG0746	molybdenum cofactor guanylyltransferase activity
GPY46_RS16625	COG3842	ATPase activity
GPY46_RS16645	COG2204	response regulator
GPY46_RS16650	COG4191	Histidine kinase
GPY46_RS16660	COG0488	(ABC) transporter
GPY46_RS16665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY46_RS16700	COG3383	formate dehydrogenase (NAD+) activity
GPY46_RS16700	COG0243	molybdopterin cofactor binding
GPY46_RS16705	COG0437	4 iron, 4 sulfur cluster binding
GPY46_RS16825	COG0004	ammonium transporteR
GPY46_RS16835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY46_RS16840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY46_RS16845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY46_RS16850	COG1177	transmembrane transport
GPY46_RS16855	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY46_RS16860	COG3842	ATPase activity
GPY46_RS16880	COG0037	tRNA processing
GPY46_RS16890	COG0589	response to stress
GPY46_RS16895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY46_RS16910	COG2217	Heavy metal translocating P-type atpase
GPY46_RS16920	COG2010	Cytochrome c
GPY46_RS16935	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY46_RS17010	COG2963	transposase activity
GPY46_RS17015	COG2801	Transposase and inactivated derivatives
GPY46_RS17065	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GPY46_RS17080	COG1401	restriction endodeoxyribonuclease activity
GPY46_RS17215	COG3120	sequence-specific DNA binding
GPY46_RS17220	COG1067	ATP-dependent peptidase activity
GPY46_RS17225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY46_RS17250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY46_RS17250	COG0116	Belongs to the methyltransferase superfamily
GPY46_RS17265	COG0167	dihydroorotate dehydrogenase activity
GPY46_RS17270	COG2902	Dehydrogenase
GPY46_RS17280	COG0308	aminopeptidase N
GPY46_RS17295	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY46_RS17300	COG1956	GAF domain-containing protein
GPY46_RS17305	COG1132	(ABC) transporter
GPY46_RS17310	COG2995	paraquat-inducible protein a
GPY46_RS17315	COG3008	intermembrane lipid transfer
GPY46_RS17320	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY46_RS17320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY46_RS17340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY46_RS17345	COG1666	GTP binding
GPY46_RS17360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY46_RS17365	COG4597	amino acid ABC transporter
GPY46_RS17370	COG0765	amino acid transport
GPY46_RS17375	COG1126	abc transporter atp-binding protein
GPY46_RS17380	COG0670	Belongs to the BI1 family
GPY46_RS17390	COG2920	part of a sulfur-relay system
GPY46_RS17395	COG1254	Belongs to the acylphosphatase family
GPY46_RS17400	COG0840	transmembrane signaling receptor activity
GPY46_RS17405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY46_RS17445	COG3706	GGDEF domain
GPY46_RS17450	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY46_RS17455	COG0602	queuosine metabolic process
GPY46_RS17460	COG0561	phosphatase activity
GPY46_RS17485	COG2828	Protein conserved in bacteria
GPY46_RS17495	COG0372	Belongs to the citrate synthase family
GPY46_RS17500	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY46_RS17530	COG0730	response to heat
GPY46_RS17550	COG0457	Tetratricopeptide repeat
GPY46_RS17615	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY46_RS17620	COG4790	Type iii secretion
GPY46_RS17625	COG4794	Type iii secretion
GPY46_RS17630	COG4791	protein targeting
GPY46_RS17635	COG4792	protein secretion
GPY46_RS17645	COG1073	alpha beta
GPY46_RS17650	COG1073	alpha beta
GPY46_RS17690	COG3177	Filamentation induced by cAMP protein fic
GPY46_RS17710	COG4669	(LipO)protein
GPY46_RS17780	COG1012	belongs to the aldehyde dehydrogenase family
GPY46_RS17785	COG3284	Transcriptional regulator
GPY46_RS17805	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY46_RS17810	COG0363	glucosamine-6-phosphate deaminase activity
GPY46_RS17815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY46_RS17820	COG4565	transcriptional regulatory protein
GPY46_RS17825	COG3290	protein histidine kinase activity
GPY46_RS17840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY46_RS17855	COG1858	cytochrome C peroxidase
GPY46_RS17860	COG0527	aspartate kinase activity
GPY46_RS17865	COG0662	Cupin 2, conserved barrel domain protein
GPY46_RS17870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY46_RS17875	COG0456	acetyltransferase
GPY46_RS17880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY46_RS17900	COG4176	ABC-type proline glycine betaine transport system permease component
GPY46_RS17905	COG2113	Glycine betaine
GPY46_RS17925	COG1028	Short-chain dehydrogenase reductase Sdr
GPY46_RS17935	COG0745	RESPONSE REGULATOR receiver
GPY46_RS17940	COG0642	Histidine kinase
GPY46_RS17945	COG1368	sulfuric ester hydrolase activity
GPY46_RS17970	COG1115	amino acid carrier protein
GPY46_RS17980	COG1280	lysine exporter protein (LysE YggA)
GPY46_RS17985	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY46_RS17990	COG1560	Kdo2-lipid A biosynthetic process
GPY46_RS18000	COG0531	amino acid
GPY46_RS18015	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY46_RS18020	COG3063	Type IV pilus biogenesis stability protein PilW
GPY46_RS18050	COG0110	maltose O-acetyltransferase activity
GPY46_RS18070	COG2315	Protein conserved in bacteria
GPY46_RS18075	COG1846	Transcriptional regulator
GPY46_RS18090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY46_RS18100	COG2200	EAL domain
GPY46_RS18100	COG2771	luxR family
GPY46_RS18110	COG1227	inorganic diphosphatase activity
GPY46_RS18115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY46_RS18125	COG2957	Belongs to the agmatine deiminase family
GPY46_RS18135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY46_RS18140	COG1012	belongs to the aldehyde dehydrogenase family
GPY46_RS18145	COG1396	sequence-specific DNA binding
GPY46_RS18145	COG1917	Cupin 2, conserved barrel domain protein
GPY46_RS18150	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY46_RS18160	COG0174	glutamine synthetase
GPY46_RS18165	COG1757	Na H antiporter
GPY46_RS18185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY46_RS18190	COG1280	lysine exporter protein (LysE YggA)
GPY46_RS18365	COG1783	phage Terminase large subunit
GPY46_RS18415	COG0557	exoribonuclease II activity
GPY46_RS18420	COG1278	Cold shock
GPY46_RS18520	COG0625	glutathione transferase activity
GPY46_RS18530	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY46_RS18540	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY46_RS18550	COG0601	transmembrane transport
GPY46_RS18555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY46_RS18560	COG0444	Belongs to the ABC transporter superfamily
GPY46_RS18580	COG3291	Pkd domain containing protein
GPY46_RS18590	COG1177	transmembrane transport
GPY46_RS18595	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY46_RS18600	COG3842	ATPase activity
GPY46_RS18605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY46_RS18610	COG2423	ornithine cyclodeaminase activity
GPY46_RS18630	COG3938	Belongs to the proline racemase family
GPY46_RS18660	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GPY46_RS18665	COG1451	nucleotide metabolic process
GPY46_RS18675	COG0583	DNA-binding transcription factor activity
GPY46_RS18695	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY46_RS18700	COG4139	cobalamin transport
GPY46_RS18705	COG2988	succinylglutamate desuccinylase activity
GPY46_RS18730	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY46_RS18735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY46_RS18740	COG0702	epimerase
GPY46_RS18750	COG2925	Exonuclease
GPY46_RS18755	COG1380	Effector of murein hydrolase LrgA
GPY46_RS18760	COG1346	cytolysis
GPY46_RS18765	COG0295	cytidine deaminase activity
GPY46_RS18770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY46_RS18775	COG0500	methyltransferase
GPY46_RS18785	COG0776	regulation of translation
GPY46_RS18800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY46_RS18800	COG0072	phenylalanine-tRNA ligase activity
GPY46_RS18805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY46_RS18810	COG3706	GGDEF domain
GPY46_RS18840	COG0393	Putative heavy-metal-binding
GPY46_RS18850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY46_RS18860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY46_RS18875	COG2188	Transcriptional regulator
GPY46_RS18880	COG1228	amidohydrolase
GPY46_RS18885	COG0010	Belongs to the arginase family
GPY46_RS18890	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY46_RS18895	COG2986	histidine ammonia-lyase
GPY46_RS18910	COG0247	lactate metabolic process
GPY46_RS18910	COG0277	FAD linked oxidase domain protein
GPY46_RS18945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY46_RS18960	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GPY46_RS18965	COG1643	Atp-dependent helicase
GPY46_RS18970	COG0281	malic enzyme
GPY46_RS18975	COG2949	membrane
GPY46_RS18980	COG0471	metal ion transport
GPY46_RS18985	COG3706	GGDEF domain
GPY46_RS18985	COG0745	RESPONSE REGULATOR receiver
GPY46_RS19005	COG0492	ferredoxin-NADP+ reductase activity
GPY46_RS19010	COG4988	ABC transporter
GPY46_RS19015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY46_RS19025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY46_RS19035	COG4191	Histidine kinase
GPY46_RS19035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY46_RS19050	COG3070	regulator of competence-specific genes
GPY46_RS19065	COG2431	L-lysine efflux transmembrane transporter activity
GPY46_RS19075	COG0076	glutamate decarboxylase activity
GPY46_RS19080	COG1737	Transcriptional regulator
GPY46_RS19095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY46_RS19100	COG3273	potassium ion transport
GPY46_RS19100	COG2985	domain, Protein
GPY46_RS19105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY46_RS19120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY46_RS19135	COG4181	ATPase activity
GPY46_RS19140	COG0534	Mate efflux family protein
GPY46_RS19145	COG0702	epimerase
GPY46_RS19150	COG3005	denitrification pathway
GPY46_RS19180	COG2814	Major facilitator Superfamily
GPY46_RS19185	COG1187	pseudouridine synthase activity
GPY46_RS19190	COG1061	Type III restriction enzyme res subunit
GPY46_RS19200	COG0745	RESPONSE REGULATOR receiver
GPY46_RS19205	COG2205	protein histidine kinase activity
GPY46_RS19210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY46_RS19240	COG3313	Fe-S protein
GPY46_RS19265	COG0493	'glutamate synthase
GPY46_RS19275	COG0398	Pfam SNARE associated Golgi protein
GPY46_RS19280	COG4134	Bacterial extracellular solute-binding protein
GPY46_RS19285	COG4135	transport system, permease component
GPY46_RS19290	COG4136	ATPase activity
GPY46_RS19295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY46_RS19310	COG3604	Transcriptional regulator
GPY46_RS19315	COG1151	hydroxylamine reductase activity
GPY46_RS19320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY46_RS19330	COG0564	pseudouridine synthase activity
GPY46_RS19340	COG0733	neurotransmitter:sodium symporter activity
GPY46_RS19350	COG0626	cystathionine gamma-synthase activity
GPY46_RS19355	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY46_RS19360	COG5380	lipid catabolic process
GPY46_RS19365	COG2818	Glycosylase
GPY46_RS19380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY46_RS19385	COG1983	PspC domain protein
GPY46_RS19395	COG1842	Phage shock protein A
GPY46_RS19400	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY46_RS19410	COG4168	peptide transport system, permease
GPY46_RS19415	COG4171	peptide transport system, permease
GPY46_RS19425	COG4172	Belongs to the ABC transporter superfamily
GPY46_RS19435	COG1227	inorganic diphosphatase activity
GPY46_RS19450	COG0243	molybdopterin cofactor binding
GPY46_RS19455	COG3005	denitrification pathway
GPY46_RS19460	COG4459	periplasmic nitrate reductase
GPY46_RS19465	COG0390	transport system, permease component
GPY46_RS19475	COG2116	formate transmembrane transporter activity
GPY46_RS19500	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY46_RS19505	COG1435	thymidine kinase activity
GPY46_RS19510	COG0215	cysteine-tRNA ligase activity
GPY46_RS19515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY46_RS19520	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY46_RS19525	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY46_RS19535	COG3012	SEC-C Motif Domain Protein
GPY46_RS19540	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY46_RS19540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY46_RS19545	COG0107	imidazoleglycerol-phosphate synthase activity
GPY46_RS19550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY46_RS19555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY46_RS19560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY46_RS19560	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY46_RS19565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY46_RS19570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY46_RS19575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY46_RS19590	COG1757	Na H antiporter
GPY46_RS19600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY46_RS19610	COG0482	sulfurtransferase activity
GPY46_RS19615	COG2915	High frequency lysogenization protein hflD homolog
GPY46_RS19620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY46_RS19645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY46_RS19660	COG0300	oxidoreductase activity
GPY46_RS19670	COG0501	Belongs to the peptidase M48B family
GPY46_RS19680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY46_RS19695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY46_RS19700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY46_RS19705	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY46_RS19720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY46_RS19725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY46_RS19730	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY46_RS19735	COG1674	ftsk spoiiie
GPY46_RS19745	COG0686	Belongs to the AlaDH PNT family
GPY46_RS19755	COG0583	DNA-binding transcription factor activity
GPY46_RS19770	COG3568	Endonuclease Exonuclease Phosphatase
GPY46_RS19800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY46_RS19805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY46_RS19820	COG0840	transmembrane signaling receptor activity
GPY46_RS19845	COG0328	RNA-DNA hybrid ribonuclease activity
GPY46_RS19875	COG5002	protein histidine kinase activity
GPY46_RS19875	COG0784	Response regulator, receiver
GPY46_RS19885	COG0754	glutathionylspermidine amidase activity
GPY46_RS19895	COG3766	membrane
GPY46_RS19905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY46_RS19910	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY46_RS19915	COG2885	chlorophyll binding
GPY46_RS19920	COG0823	Involved in the tonB-independent uptake of proteins
GPY46_RS19935	COG0811	peptide transport
GPY46_RS19940	COG0824	Thioesterase
GPY46_RS19950	COG4890	Cyd operon protein YbgT
GPY46_RS19955	COG1294	oxidase, subunit
GPY46_RS19960	COG1271	oxidase subunit
GPY46_RS19965	COG2255	four-way junction helicase activity
GPY46_RS19970	COG0632	four-way junction helicase activity
GPY46_RS19975	COG0840	transmembrane signaling receptor activity
GPY46_RS19980	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY46_RS19985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY46_RS19990	COG1801	Protein of unknown function DUF72
GPY46_RS19995	COG4106	trans-aconitate 2-methyltransferase activity
GPY46_RS20000	COG0500	methyltransferase
GPY46_RS20010	COG4067	protein conserved in archaea
GPY46_RS20010	COG0189	ligase activity
GPY46_RS20030	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY46_RS20035	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY46_RS20040	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY46_RS20045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY46_RS20050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY46_RS20055	COG0745	RESPONSE REGULATOR receiver
GPY46_RS20060	COG3381	protein complex oligomerization
GPY46_RS20065	COG1609	Transcriptional regulator
GPY46_RS20070	COG3070	regulator of competence-specific genes
GPY46_RS20090	COG0297	glycogen (starch) synthase activity
GPY46_RS20095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY46_RS20100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY46_RS20110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY46_RS20120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY46_RS20125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY46_RS20130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY46_RS20140	COG0542	response to heat
GPY46_RS20145	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY46_RS20150	COG1278	Cold shock
GPY46_RS20160	COG1187	pseudouridine synthase activity
GPY46_RS20165	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY46_RS20170	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY46_RS20175	COG1199	ATP-dependent helicase activity
GPY46_RS20180	COG0730	response to heat
GPY46_RS20185	COG3923	Primosomal replication protein n
GPY46_RS20195	COG0708	Exodeoxyribonuclease III
GPY46_RS20210	COG4215	(ABC) transporter
GPY46_RS20240	COG1882	Formate acetyltransferase
GPY46_RS20250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY46_RS20260	COG3013	Belongs to the UPF0304 family
GPY46_RS20270	COG2766	serine protein kinase
GPY46_RS20275	COG2718	Belongs to the UPF0229 family
GPY46_RS20280	COG2719	SpoVR family
GPY46_RS20285	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY46_RS20295	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY46_RS20300	COG1132	(ABC) transporter
GPY46_RS20305	COG0658	competence protein
GPY46_RS20305	COG2333	competence protein COMEC
GPY46_RS20315	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY46_RS20320	COG1136	(ABC) transporter
GPY46_RS20325	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY46_RS20335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY46_RS20350	COG1252	NADH dehydrogenase
GPY46_RS20360	COG3150	esterase
GPY46_RS20385	COG0537	adenosine 5'-monophosphoramidase activity
GPY46_RS20415	COG0516	GMP reductase activity
GPY46_RS20415	COG0517	IMP dehydrogenase activity
GPY46_RS20425	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY46_RS20430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY46_RS20435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY46_RS20445	COG2199	diguanylate cyclase activity
GPY46_RS20460	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY46_RS20465	COG1946	Acyl-CoA thioesterase
GPY46_RS20475	COG1522	sequence-specific DNA binding
GPY46_RS20505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY46_RS20510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY46_RS20555	COG0477	Major facilitator Superfamily
GPY46_RS20560	COG2855	membrane
GPY46_RS20575	COG1441	menaquinone biosynthetic process
GPY46_RS20580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY46_RS20585	COG0596	Alpha beta hydrolase
GPY46_RS20590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY46_RS20595	COG1169	isochorismate synthase
GPY46_RS20600	COG0436	Aminotransferase
GPY46_RS20605	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY46_RS20610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY46_RS20625	COG1555	photosystem II stabilization
GPY46_RS20630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY46_RS20635	COG0776	regulation of translation
GPY46_RS20640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY46_RS20645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY46_RS20655	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY46_RS20665	COG2204	response regulator
GPY46_RS20675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY46_RS20680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY46_RS20685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY46_RS20690	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY46_RS20710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY46_RS20715	COG0569	domain protein
GPY46_RS20720	COG0513	Belongs to the DEAD box helicase family
GPY46_RS20725	COG1253	flavin adenine dinucleotide binding
GPY46_RS20760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY46_RS20765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY46_RS20780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY46_RS20785	COG1216	Glycosyl transferase, family 2
GPY46_RS20790	COG2986	histidine ammonia-lyase
GPY46_RS20815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY46_RS20820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY46_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
GPY46_RS20845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY46_RS20850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY46_RS20855	COG0583	DNA-binding transcription factor activity
GPY46_RS20860	COG2951	lytic endotransglycosylase activity
GPY46_RS20865	COG3100	YcgL domain-containing protein
GPY46_RS20870	COG0850	regulation of cytokinetic process
GPY46_RS20875	COG2894	cell division
GPY46_RS20880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY46_RS20885	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY46_RS20890	COG0318	PFAM AMP-dependent synthetase and ligase
GPY46_RS20895	COG2267	carboxylic ester hydrolase activity
GPY46_RS20910	COG1214	PFAM Peptidase M22, glycoprotease
GPY46_RS20915	COG1199	ATP-dependent helicase activity
GPY46_RS20920	COG0788	formyltetrahydrofolate deformylase activity
GPY46_RS20925	COG3102	Protein conserved in bacteria
GPY46_RS20935	COG0018	arginyl-trna synthetase
GPY46_RS20955	COG1918	ferrous iron import across plasma membrane
GPY46_RS20970	COG4977	sequence-specific DNA binding
GPY46_RS20975	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY46_RS20980	COG1121	(ABC) transporter
GPY46_RS20985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY46_RS20990	COG0121	glutamine amidotransferase
GPY46_RS20995	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY46_RS21000	COG1960	acyl-CoA dehydrogenase activity
GPY46_RS21010	COG0456	acetyltransferase
GPY46_RS21025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY46_RS21030	COG0328	RNA-DNA hybrid ribonuclease activity
GPY46_RS21035	COG2226	methyltransferase
GPY46_RS21040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY46_RS21045	COG0741	lytic transglycosylase activity
GPY46_RS21045	COG1388	LysM domain
GPY46_RS21055	COG3021	interspecies interaction between organisms
GPY46_RS21060	COG0347	Belongs to the P(II) protein family
GPY46_RS21070	COG0037	tRNA processing
GPY46_RS21075	COG0825	malonyl-CoA metabolic process
GPY46_RS21080	COG0587	DNA-directed DNA polymerase activity
GPY46_RS21090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY46_RS21095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY46_RS21100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY46_RS21105	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY46_RS21115	COG0750	zinc metalloprotease
GPY46_RS21120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY46_RS21125	COG0575	Belongs to the CDS family
GPY46_RS21130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY46_RS21135	COG0233	cytoplasmic translational termination
GPY46_RS21140	COG0528	UMP kinase activity
GPY46_RS21145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY46_RS21150	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY46_RS21155	COG0024	Methionine aminopeptidase
GPY46_RS21160	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY46_RS21170	COG0564	pseudouridine synthase activity
GPY46_RS21175	COG3098	single-species biofilm formation
GPY46_RS21200	COG1671	Belongs to the UPF0178 family
GPY46_RS21205	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY46_RS21220	COG0254	rRNA binding
GPY46_RS21225	COG1720	tRNA m6t6A37 methyltransferase activity
GPY46_RS21230	COG0442	prolyl-tRNA aminoacylation
GPY46_RS21250	COG0733	neurotransmitter:sodium symporter activity
GPY46_RS21265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY46_RS21270	COG0514	ATP-dependent DNA helicase (RecQ)
GPY46_RS21275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY46_RS21290	COG1477	protein flavinylation
GPY46_RS21295	COG2871	sodium ion transport
GPY46_RS21300	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY46_RS21305	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY46_RS21310	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY46_RS21315	COG1805	sodium ion transport
GPY46_RS21320	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY46_RS21325	COG0271	Belongs to the BolA IbaG family
GPY46_RS21330	COG2813	Specifically methylates the guanine in position
GPY46_RS21335	COG3056	Lipoprotein
GPY46_RS21355	COG1595	DNA-templated transcription, initiation
GPY46_RS21385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY46_RS21390	COG0693	protein deglycase activity
GPY46_RS21395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY46_RS21400	COG3706	GGDEF domain
GPY46_RS21405	COG2166	iron-sulfur cluster assembly
GPY46_RS21410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY46_RS21415	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY46_RS21425	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY46_RS21425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY46_RS21435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY46_RS21440	COG1074	ATP-dependent DNA helicase activity
GPY46_RS21445	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY46_RS21465	COG3141	response to X-ray
GPY46_RS21470	COG2171	N-acyltransferase activity
GPY46_RS21475	COG0584	glycerophosphoryl diester phosphodiesterase
GPY46_RS21480	COG2271	Major facilitator Superfamily
GPY46_RS21495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY46_RS21500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY46_RS21505	COG1349	DNA-binding transcription factor activity
GPY46_RS21510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY46_RS21515	COG0598	Magnesium transport protein CorA
GPY46_RS21530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY46_RS21535	COG1609	Transcriptional regulator
GPY46_RS21540	COG2211	Major facilitator Superfamily
GPY46_RS21555	COG2017	converts alpha-aldose to the beta-anomer
GPY46_RS21560	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY46_RS21570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY46_RS21580	COG1609	Transcriptional regulator
GPY46_RS21585	COG3250	beta-galactosidase activity
GPY46_RS21590	COG2731	YhcH YjgK YiaL family protein
GPY46_RS21595	COG0531	amino acid
GPY46_RS21600	COG0583	DNA-binding transcription factor activity
GPY46_RS21660	COG4964	Belongs to the GSP D family
GPY46_RS21685	COG2169	Transcriptional regulator
GPY46_RS21690	COG1022	Amp-dependent synthetase and ligase
GPY46_RS21700	COG0583	DNA-binding transcription factor activity
GPY46_RS21705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY46_RS21710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY46_RS21720	COG0560	Phosphoserine phosphatase
GPY46_RS21730	COG0813	purine-nucleoside phosphorylase activity
GPY46_RS21735	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY46_RS21740	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY46_RS21745	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY46_RS21750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY46_RS21755	COG0084	hydrolase, TatD family'
GPY46_RS21765	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY46_RS21785	COG3153	acetyltransferase
GPY46_RS21810	COG0534	Mate efflux family protein
GPY46_RS21825	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY46_RS21830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY46_RS21835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY46_RS21840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY46_RS21845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY46_RS21850	COG0195	Participates in both transcription termination and antitermination
GPY46_RS21855	COG0779	Required for maturation of 30S ribosomal subunits
GPY46_RS21870	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY46_RS21880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY46_RS21885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY46_RS21890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY46_RS21895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY46_RS21900	COG1534	Rna-binding protein
GPY46_RS21905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY46_RS21910	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY46_RS21915	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY46_RS21925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY46_RS21930	COG0739	heme binding
GPY46_RS21935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY46_RS21945	COG0316	Belongs to the HesB IscA family
GPY46_RS21950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY46_RS21955	COG0628	permease
GPY46_RS21960	COG2813	Specifically methylates the guanine in position
GPY46_RS21965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY46_RS21965	COG2198	Histidine kinase
GPY46_RS21965	COG2205	protein histidine kinase activity
GPY46_RS21965	COG0784	Response regulator, receiver
GPY46_RS21970	COG0747	negative chemotaxis
GPY46_RS21980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY46_RS21985	COG0444	Belongs to the ABC transporter superfamily
GPY46_RS21990	COG4608	Belongs to the ABC transporter superfamily
GPY46_RS22000	COG2971	BadF BadG BcrA BcrD
GPY46_RS22015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY46_RS22020	COG3842	ATPase activity
GPY46_RS22030	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY46_RS22035	COG0004	ammonium transporteR
GPY46_RS22045	COG3112	Uncharacterised protein family (UPF0231)
GPY46_RS22050	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY46_RS22055	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY46_RS22060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY46_RS22065	COG1643	Atp-dependent helicase
GPY46_RS22070	COG1489	DNA binding
GPY46_RS22075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY46_RS22085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY46_RS22100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY46_RS22105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY46_RS22110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY46_RS22115	COG1560	Kdo2-lipid A biosynthetic process
GPY46_RS22125	COG1131	(ABC) transporter
GPY46_RS22135	COG0659	secondary active sulfate transmembrane transporter activity
GPY46_RS22140	COG0288	reversible hydration of carbon dioxide
GPY46_RS22155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY46_RS22160	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY46_RS22165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY46_RS22170	COG2186	Transcriptional regulator
GPY46_RS22180	COG0157	Belongs to the NadC ModD family
GPY46_RS22190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY46_RS22195	COG1459	type II secretion system
GPY46_RS22205	COG0237	dephospho-CoA kinase activity
GPY46_RS22210	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY46_RS22215	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY46_RS22220	COG0335	large ribosomal subunit rRNA binding
GPY46_RS22225	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY46_RS22230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY46_RS22235	COG0228	four-way junction DNA binding
GPY46_RS22240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY46_RS22245	COG4137	Cytochrome C assembly protein
GPY46_RS22250	COG4536	flavin adenine dinucleotide binding
GPY46_RS22255	COG1854	S-ribosylhomocysteine lyase activity
GPY46_RS22265	COG2918	glutathione biosynthetic process
GPY46_RS22270	COG0612	Peptidase, M16
GPY46_RS22275	COG1238	metal cluster binding
GPY46_RS22280	COG1063	alcohol dehydrogenase
GPY46_RS22285	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY46_RS22290	COG0511	ligase activity, forming carbon-carbon bonds
GPY46_RS22290	COG5016	pyruvate
GPY46_RS22295	COG3630	sodium ion export across plasma membrane
GPY46_RS22355	COG0527	aspartate kinase activity
GPY46_RS22360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY46_RS22365	COG2137	regulation of response to DNA damage stimulus
GPY46_RS22370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY46_RS22375	COG1546	Belongs to the CinA family
GPY46_RS22380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY46_RS22395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY46_RS22400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY46_RS22405	COG0585	pseudouridine synthase activity
GPY46_RS22410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY46_RS22415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY46_RS22420	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY46_RS22425	COG0148	phosphopyruvate hydratase activity
GPY46_RS22430	COG0504	CTP synthase activity
GPY46_RS22435	COG3956	TIGRFAM MazG family protein
GPY46_RS22450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY46_RS22460	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY46_RS22465	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY46_RS22470	COG1381	Involved in DNA repair and RecF pathway recombination
GPY46_RS22475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY46_RS22480	COG0571	ribonuclease III activity
GPY46_RS22485	COG0681	Belongs to the peptidase S26 family
GPY46_RS22490	COG0481	GTPase activity
GPY46_RS22495	COG3086	response to oxidative stress
GPY46_RS22505	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPY46_RS22510	COG1595	DNA-templated transcription, initiation
GPY46_RS22520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY46_RS22530	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY46_RS22535	COG0354	folic acid binding
GPY46_RS22550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY46_RS22555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY46_RS22560	COG3079	Belongs to the UPF0149 family
GPY46_RS22570	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY46_RS22580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY46_RS22585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY46_RS22590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY46_RS22600	COG0583	DNA-binding transcription factor activity
GPY46_RS22610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY46_RS22615	COG0668	transmembrane transport
GPY46_RS22620	COG0191	fructose-bisphosphate aldolase activity
GPY46_RS22625	COG0126	phosphoglycerate kinase activity
GPY46_RS22630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY46_RS22635	COG4771	TonB-dependent receptor
GPY46_RS22640	COG0583	DNA-binding transcription factor activity
GPY46_RS22645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY46_RS22655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY46_RS22665	COG3091	SprT-like family
GPY46_RS22670	COG2356	endonuclease I
GPY46_RS22675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY46_RS22680	COG0189	ligase activity
GPY46_RS22685	COG1678	Uncharacterized ACR, COG1678
GPY46_RS22690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY46_RS22705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY46_RS22710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY46_RS22715	COG0762	integral membrane protein
GPY46_RS22720	COG1872	DUF167
GPY46_RS22730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY46_RS22735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY46_RS22740	COG2066	Belongs to the glutaminase family
GPY46_RS22750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY46_RS22760	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY46_RS22765	COG0741	lytic transglycosylase activity
GPY46_RS22835	COG1012	belongs to the aldehyde dehydrogenase family
GPY46_RS22885	COG3437	response regulator, receiver
GPY46_RS22895	COG3394	polysaccharide catabolic process
GPY46_RS22900	COG1486	melibiose metabolic process
GPY46_RS22905	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY46_RS22910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY46_RS22915	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY46_RS22920	COG0726	polysaccharide deacetylase
GPY46_RS22930	COG1028	Short-chain dehydrogenase reductase Sdr
GPY46_RS22935	COG4325	translation initiation factor activity
GPY46_RS22945	COG0795	lipopolysaccharide-transporting ATPase activity
GPY46_RS22950	COG0795	lipopolysaccharide-transporting ATPase activity
GPY46_RS22955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY46_RS22960	COG2927	DNA polymerase III (CHI subunit)
GPY46_RS22965	COG0525	valine-tRNA ligase activity
GPY46_RS22995	COG2235	arginine
GPY46_RS23000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY46_RS23010	COG0540	Belongs to the ATCase OTCase family
GPY46_RS23015	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY46_RS23020	COG0251	oxidation-reduction process
GPY46_RS23025	COG0204	Acyl-transferase
GPY46_RS23030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY46_RS23035	COG5007	Belongs to the BolA IbaG family
GPY46_RS23045	COG2854	intermembrane phospholipid transfer
GPY46_RS23050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY46_RS23055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY46_RS23060	COG1127	ABC transporter
GPY46_RS23070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY46_RS23070	COG0517	IMP dehydrogenase activity
GPY46_RS23080	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY46_RS23085	COG1137	ATPase activity
GPY46_RS23095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY46_RS23100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY46_RS23105	COG1660	Displays ATPase and GTPase activities
GPY46_RS23110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY46_RS23115	COG2239	Acts as a magnesium transporter
GPY46_RS23120	COG0312	modulator of DNA gyrase
GPY46_RS23125	COG3028	Belongs to the UPF0307 family
GPY46_RS23130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY46_RS23135	COG0564	pseudouridine synthase activity
GPY46_RS23150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY46_RS23155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY46_RS23160	COG0312	modulator of DNA gyrase
GPY46_RS23170	COG3164	Protein of unknown function
GPY46_RS23175	COG1530	ribonuclease E activity
GPY46_RS23180	COG0424	maF-like protein
GPY46_RS23185	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY46_RS23190	COG1792	Involved in formation and maintenance of cell shape
GPY46_RS23195	COG1077	Cell shape determining protein MreB Mrl
GPY46_RS23240	COG1459	type II secretion system
GPY46_RS23245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY46_RS23255	COG3267	Type II secretory pathway component ExeA
GPY46_RS23255	COG3409	Peptidoglycan-binding domain 1 protein
GPY46_RS23280	COG2200	EAL domain
GPY46_RS23280	COG2199	diguanylate cyclase activity
GPY46_RS23285	COG0629	single-stranded DNA binding
GPY46_RS23300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY46_RS23310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY46_RS23315	COG0527	aspartate kinase activity
GPY46_RS23320	COG0646	methionine synthase
GPY46_RS23320	COG1410	methionine synthase
GPY46_RS23335	COG3335	DDE superfamily endonuclease
GPY46_RS23395	COG0175	sulfate reduction
GPY46_RS23400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY46_RS23405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY46_RS23430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY46_RS23435	COG0582	viral genome integration into host DNA
GPY46_RS23440	COG0582	viral genome integration into host DNA
GPY46_RS23470	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY46_RS23500	COG0735	belongs to the Fur family
GPY46_RS23510	COG0166	Belongs to the GPI family
GPY46_RS23515	COG0432	Pfam Uncharacterised protein family UPF0047
GPY46_RS23525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY46_RS23530	COG0305	Participates in initiation and elongation during chromosome replication
GPY46_RS23540	COG0359	binds to the 23S rRNA
GPY46_RS23550	COG2965	DNA replication, synthesis of RNA primer
GPY46_RS23555	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY46_RS23560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY46_RS23565	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY46_RS23575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY46_RS23580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY46_RS23610	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY46_RS23620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY46_RS23620	COG0678	peroxiredoxin activity
GPY46_RS23635	COG0165	Argininosuccinate lyase
GPY46_RS23635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY46_RS23640	COG0137	argininosuccinate synthase activity
GPY46_RS23645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY46_RS23650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY46_RS23655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY46_RS23660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY46_RS23670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY46_RS23675	COG0460	homoserine dehydrogenase
GPY46_RS23675	COG0527	aspartate kinase activity
GPY46_RS23680	COG0626	cystathionine gamma-synthase activity
GPY46_RS23690	COG0281	malic enzyme
GPY46_RS23700	COG2906	2 iron, 2 sulfur cluster binding
GPY46_RS23705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY46_RS23710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY46_RS23715	COG0049	tRNA binding
GPY46_RS23725	COG2168	tRNA wobble position uridine thiolation
GPY46_RS23730	COG2923	Belongs to the DsrF TusC family
GPY46_RS23735	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY46_RS23740	COG2964	Protein conserved in bacteria
GPY46_RS23745	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY46_RS23755	COG2900	Belongs to the SlyX family
GPY46_RS23760	COG1446	asparaginase
GPY46_RS23770	COG1047	Peptidyl-prolyl cis-trans
GPY46_RS23785	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY46_RS23795	COG0488	(ABC) transporter
GPY46_RS23805	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY46_RS23810	COG3089	Belongs to the UPF0270 family
GPY46_RS23815	COG3954	Phosphoribulokinase
GPY46_RS23820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY46_RS23830	COG1012	belongs to the aldehyde dehydrogenase family
GPY46_RS23840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY46_RS23845	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY46_RS23875	COG0180	Tryptophanyl-tRNA synthetase
GPY46_RS23880	COG0546	phosphoglycolate phosphatase activity
GPY46_RS23885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY46_RS23890	COG0557	exoribonuclease II activity
GPY46_RS23895	COG1959	2 iron, 2 sulfur cluster binding
GPY46_RS23900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY46_RS23900	COG1017	nitric oxide dioxygenase activity
GPY46_RS23905	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY46_RS23915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY46_RS23920	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY46_RS23925	COG0330	HflC and HflK could
GPY46_RS23930	COG0330	HflC and HflK could
GPY46_RS23935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY46_RS23945	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY46_RS23950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY46_RS23955	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPY46_RS23960	COG0802	atpase or kinase
GPY46_RS23965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY46_RS24035	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY46_RS24040	COG1162	GTPase activity
GPY46_RS24045	COG0688	phosphatidylethanolamine metabolic process
GPY46_RS24050	COG0471	metal ion transport
GPY46_RS24065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY46_RS24070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY46_RS24075	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY46_RS24080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY46_RS24085	COG1045	serine acetyltransferase
GPY46_RS24090	COG4942	peptidase
GPY46_RS24110	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY46_RS24120	COG1053	succinate dehydrogenase
GPY46_RS24125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY46_RS24130	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY46_RS24135	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY46_RS24145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY46_RS24150	COG1509	lysine 2,3-aminomutase activity
GPY46_RS24160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY46_RS24175	COG0459	protein refolding
GPY46_RS24180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY46_RS24185	COG0534	Mate efflux family protein
GPY46_RS24190	COG0205	6-phosphofructokinase activity
GPY46_RS24200	COG3678	ATP-independent chaperone mediated protein folding
GPY46_RS24205	COG0745	RESPONSE REGULATOR receiver
GPY46_RS24210	COG2205	protein histidine kinase activity
GPY46_RS24220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY46_RS24225	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY46_RS24230	COG1027	Aspartate ammonia-lyase
GPY46_RS24235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY46_RS24240	COG4232	protein-disulfide reductase activity
GPY46_RS24250	COG3263	regulation of cellular component size
GPY46_RS24260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY46_RS24285	COG2205	protein histidine kinase activity
GPY46_RS24285	COG0784	Response regulator, receiver
GPY46_RS24290	COG2814	Major facilitator Superfamily
GPY46_RS24305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY46_RS24310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY46_RS24315	COG0511	ligase activity, forming carbon-carbon bonds
GPY46_RS24320	COG0439	Biotin carboxylase
GPY46_RS24330	COG2264	protein methyltransferase activity
GPY46_RS24335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY46_RS24340	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY46_RS24345	COG2814	Major facilitator Superfamily
GPY46_RS24350	COG0488	(ABC) transporter
GPY46_RS24355	COG3706	GGDEF domain
GPY46_RS24365	COG3335	DDE superfamily endonuclease
GPY46_RS24425	COG1982	Orn Lys Arg decarboxylase major
GPY46_RS24430	COG0531	amino acid
GPY46_RS24440	COG3710	Transcriptional regulator
GPY46_RS24445	COG0789	Transcriptional regulator
GPY46_RS24455	COG0138	bifunctional purine biosynthesis protein purh
GPY46_RS24465	COG0151	Belongs to the GarS family
GPY46_RS24480	COG1253	flavin adenine dinucleotide binding
GPY46_RS24485	COG3068	Protein conserved in bacteria
GPY46_RS24490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY46_RS24495	COG1573	uracil-dna glycosylase
GPY46_RS24500	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY46_RS24515	COG2816	NAD+ diphosphatase activity
GPY46_RS24520	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY46_RS24525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY46_RS24530	COG0085	RNA polymerase activity
GPY46_RS24535	COG0222	ribosome binding
GPY46_RS24540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY46_RS24545	COG0081	regulation of translation
GPY46_RS24550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY46_RS24555	COG0250	Participates in transcription elongation, termination and antitermination
GPY46_RS24560	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY46_RS24570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY46_RS24605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY46_RS24615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY46_RS24670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY46_RS24680	COG4206	TonB-dependent receptor
GPY46_RS24685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY46_RS24700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY46_RS24705	COG0534	Mate efflux family protein
GPY46_RS24710	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY46_RS24715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY46_RS24725	COG2937	Belongs to the GPAT DAPAT family
GPY46_RS24730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY46_RS24735	COG3161	chorismate lyase activity
GPY46_RS24740	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY46_RS24745	COG0705	Rhomboid family
GPY46_RS24750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY46_RS24760	COG2177	Part of the ABC transporter FtsEX involved in
GPY46_RS24765	COG2884	Cell division ATP-binding protein ftsE
GPY46_RS24770	COG0552	protein localization to endoplasmic reticulum
GPY46_RS24775	COG0742	ribosomal rna small subunit methyltransferase
GPY46_RS24785	COG2095	MarC family integral membrane protein
GPY46_RS24840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY46_RS24845	COG0640	Transcriptional regulator
GPY46_RS24850	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY46_RS24855	COG1280	lysine exporter protein (LysE YggA)
GPY46_RS24860	COG2267	carboxylic ester hydrolase activity
GPY46_RS24865	COG0561	phosphatase activity
GPY46_RS24885	COG3287	FIST C domain
GPY46_RS24885	COG2200	EAL domain
GPY46_RS24885	COG2199	diguanylate cyclase activity
GPY46_RS24890	COG1011	Hydrolase
GPY46_RS24895	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY46_RS24905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY46_RS24910	COG0019	diaminopimelate decarboxylase activity
GPY46_RS24920	COG1965	Belongs to the frataxin family
GPY46_RS24925	COG3072	Adenylate cyclase
GPY46_RS24930	COG0181	hydroxymethylbilane synthase activity
GPY46_RS24935	COG1587	Uroporphyrinogen-III synthase
GPY46_RS24940	COG2959	enzyme of heme biosynthesis
GPY46_RS24945	COG3071	HemY protein
GPY46_RS25000	COG0633	Ferredoxin
GPY46_RS25005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY46_RS25020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY46_RS25025	COG3118	belongs to the thioredoxin family
GPY46_RS25030	COG0513	Belongs to the DEAD box helicase family
GPY46_RS25035	COG0248	Ppx GppA phosphatase
GPY46_RS25040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY46_RS25055	COG0514	ATP-dependent DNA helicase (RecQ)
GPY46_RS25060	COG2962	Rard protein
GPY46_RS25070	COG1280	lysine exporter protein (LysE YggA)
GPY46_RS25075	COG0405	Gamma-glutamyltransferase
GPY46_RS25085	COG0210	DNA helicase
GPY46_RS25095	COG3220	belongs to the UPF0276 family
GPY46_RS25125	COG0006	proline dipeptidase activity
GPY46_RS25125	COG0006	proline dipeptidase activity
GPY46_RS25135	COG2022	thiamine diphosphate biosynthetic process
GPY46_RS25140	COG2104	thiamine diphosphate biosynthetic process
GPY46_RS25145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY46_RS25150	COG0352	thiamine-phosphate diphosphorylase activity
GPY46_RS25155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY46_RS25160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity