locus-tag	class	description
GPY27_RS00040	COG3706	GGDEF domain
GPY27_RS00045	COG0488	(ABC) transporter
GPY27_RS00050	COG2814	Major facilitator Superfamily
GPY27_RS00055	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY27_RS00060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY27_RS00065	COG2264	protein methyltransferase activity
GPY27_RS00075	COG0439	Biotin carboxylase
GPY27_RS00080	COG0511	ligase activity, forming carbon-carbon bonds
GPY27_RS00085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY27_RS00090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY27_RS00105	COG2814	Major facilitator Superfamily
GPY27_RS00110	COG2205	protein histidine kinase activity
GPY27_RS00110	COG0784	Response regulator, receiver
GPY27_RS00135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY27_RS00145	COG3263	regulation of cellular component size
GPY27_RS00155	COG4232	protein-disulfide reductase activity
GPY27_RS00160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY27_RS00165	COG1027	Aspartate ammonia-lyase
GPY27_RS00170	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY27_RS00175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY27_RS00185	COG2205	protein histidine kinase activity
GPY27_RS00190	COG0745	RESPONSE REGULATOR receiver
GPY27_RS00195	COG3678	ATP-independent chaperone mediated protein folding
GPY27_RS00205	COG0205	6-phosphofructokinase activity
GPY27_RS00210	COG0534	Mate efflux family protein
GPY27_RS00215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY27_RS00220	COG0459	protein refolding
GPY27_RS00235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY27_RS00245	COG1509	lysine 2,3-aminomutase activity
GPY27_RS00250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY27_RS00260	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY27_RS00265	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY27_RS00270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY27_RS00275	COG1053	succinate dehydrogenase
GPY27_RS00285	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY27_RS00305	COG4942	peptidase
GPY27_RS00310	COG1045	serine acetyltransferase
GPY27_RS00315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY27_RS00320	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY27_RS00325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY27_RS00330	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY27_RS00345	COG0471	metal ion transport
GPY27_RS00350	COG0688	phosphatidylethanolamine metabolic process
GPY27_RS00355	COG1162	GTPase activity
GPY27_RS00360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY27_RS00430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY27_RS00435	COG0802	atpase or kinase
GPY27_RS00440	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPY27_RS00445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY27_RS00450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY27_RS00460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY27_RS00465	COG0330	HflC and HflK could
GPY27_RS00470	COG0330	HflC and HflK could
GPY27_RS00475	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY27_RS00480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY27_RS00490	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY27_RS00495	COG1017	nitric oxide dioxygenase activity
GPY27_RS00495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY27_RS00500	COG1959	2 iron, 2 sulfur cluster binding
GPY27_RS00505	COG0557	exoribonuclease II activity
GPY27_RS00510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY27_RS00515	COG0546	phosphoglycolate phosphatase activity
GPY27_RS00520	COG0180	Tryptophanyl-tRNA synthetase
GPY27_RS00550	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY27_RS00555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY27_RS00565	COG1012	belongs to the aldehyde dehydrogenase family
GPY27_RS00575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY27_RS00580	COG3954	Phosphoribulokinase
GPY27_RS00585	COG3089	Belongs to the UPF0270 family
GPY27_RS00590	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY27_RS00600	COG0488	(ABC) transporter
GPY27_RS00610	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY27_RS00625	COG1047	Peptidyl-prolyl cis-trans
GPY27_RS00635	COG1446	asparaginase
GPY27_RS00640	COG2900	Belongs to the SlyX family
GPY27_RS00650	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY27_RS00655	COG2964	Protein conserved in bacteria
GPY27_RS00660	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY27_RS00665	COG2923	Belongs to the DsrF TusC family
GPY27_RS00670	COG2168	tRNA wobble position uridine thiolation
GPY27_RS00680	COG0049	tRNA binding
GPY27_RS00685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY27_RS00690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY27_RS00695	COG2906	2 iron, 2 sulfur cluster binding
GPY27_RS00705	COG0281	malic enzyme
GPY27_RS00715	COG0626	cystathionine gamma-synthase activity
GPY27_RS00720	COG0527	aspartate kinase activity
GPY27_RS00720	COG0460	homoserine dehydrogenase
GPY27_RS00725	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY27_RS00735	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY27_RS00740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY27_RS00745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY27_RS00750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY27_RS00755	COG0137	argininosuccinate synthase activity
GPY27_RS00760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY27_RS00760	COG0165	Argininosuccinate lyase
GPY27_RS00775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY27_RS00775	COG0678	peroxiredoxin activity
GPY27_RS00785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY27_RS00815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY27_RS00820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY27_RS00830	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY27_RS00835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY27_RS00840	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY27_RS00845	COG2965	DNA replication, synthesis of RNA primer
GPY27_RS00855	COG0359	binds to the 23S rRNA
GPY27_RS00865	COG0305	Participates in initiation and elongation during chromosome replication
GPY27_RS00870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY27_RS00880	COG0432	Pfam Uncharacterised protein family UPF0047
GPY27_RS00885	COG0166	Belongs to the GPI family
GPY27_RS00895	COG0735	belongs to the Fur family
GPY27_RS00905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY27_RS00930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY27_RS00935	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY27_RS00940	COG0175	sulfate reduction
GPY27_RS01010	COG0646	methionine synthase
GPY27_RS01010	COG1410	methionine synthase
GPY27_RS01015	COG0527	aspartate kinase activity
GPY27_RS01020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY27_RS01030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY27_RS01045	COG0629	single-stranded DNA binding
GPY27_RS01050	COG2200	EAL domain
GPY27_RS01050	COG2199	diguanylate cyclase activity
GPY27_RS01075	COG3267	Type II secretory pathway component ExeA
GPY27_RS01075	COG3409	Peptidoglycan-binding domain 1 protein
GPY27_RS01085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY27_RS01090	COG1459	type II secretion system
GPY27_RS01135	COG1077	Cell shape determining protein MreB Mrl
GPY27_RS01140	COG1792	Involved in formation and maintenance of cell shape
GPY27_RS01145	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY27_RS01150	COG0424	maF-like protein
GPY27_RS01155	COG1530	ribonuclease E activity
GPY27_RS01160	COG3164	Protein of unknown function
GPY27_RS01165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY27_RS01170	COG0312	modulator of DNA gyrase
GPY27_RS01175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY27_RS01180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY27_RS01195	COG0564	pseudouridine synthase activity
GPY27_RS01200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY27_RS01205	COG3028	Belongs to the UPF0307 family
GPY27_RS01210	COG0312	modulator of DNA gyrase
GPY27_RS01215	COG2239	Acts as a magnesium transporter
GPY27_RS01220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY27_RS01225	COG1660	Displays ATPase and GTPase activities
GPY27_RS01230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY27_RS01235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY27_RS01245	COG1137	ATPase activity
GPY27_RS01250	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY27_RS01260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY27_RS01260	COG0517	IMP dehydrogenase activity
GPY27_RS01270	COG1127	ABC transporter
GPY27_RS01275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY27_RS01280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY27_RS01285	COG2854	intermembrane phospholipid transfer
GPY27_RS01295	COG5007	Belongs to the BolA IbaG family
GPY27_RS01300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY27_RS01305	COG0204	Acyl-transferase
GPY27_RS01310	COG0251	oxidation-reduction process
GPY27_RS01315	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY27_RS01320	COG0540	Belongs to the ATCase OTCase family
GPY27_RS01330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY27_RS01335	COG2235	arginine
GPY27_RS01365	COG0525	valine-tRNA ligase activity
GPY27_RS01370	COG2927	DNA polymerase III (CHI subunit)
GPY27_RS01375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY27_RS01380	COG0795	lipopolysaccharide-transporting ATPase activity
GPY27_RS01385	COG0795	lipopolysaccharide-transporting ATPase activity
GPY27_RS01395	COG4325	translation initiation factor activity
GPY27_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS01410	COG0726	polysaccharide deacetylase
GPY27_RS01415	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY27_RS01420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY27_RS01425	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY27_RS01430	COG1486	melibiose metabolic process
GPY27_RS01435	COG3394	polysaccharide catabolic process
GPY27_RS01445	COG3437	response regulator, receiver
GPY27_RS01495	COG1012	belongs to the aldehyde dehydrogenase family
GPY27_RS01565	COG0741	lytic transglycosylase activity
GPY27_RS01570	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY27_RS01580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY27_RS01590	COG2066	Belongs to the glutaminase family
GPY27_RS01595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY27_RS01600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY27_RS01610	COG1872	DUF167
GPY27_RS01615	COG0762	integral membrane protein
GPY27_RS01620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY27_RS01625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY27_RS01640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY27_RS01645	COG1678	Uncharacterized ACR, COG1678
GPY27_RS01650	COG0189	ligase activity
GPY27_RS01655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY27_RS01660	COG2356	endonuclease I
GPY27_RS01665	COG3091	SprT-like family
GPY27_RS01675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY27_RS01685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY27_RS01690	COG0583	DNA-binding transcription factor activity
GPY27_RS01695	COG4771	TonB-dependent receptor
GPY27_RS01700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY27_RS01705	COG0126	phosphoglycerate kinase activity
GPY27_RS01710	COG0191	fructose-bisphosphate aldolase activity
GPY27_RS01715	COG0668	transmembrane transport
GPY27_RS01720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY27_RS01730	COG0583	DNA-binding transcription factor activity
GPY27_RS01740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY27_RS01745	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY27_RS01750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY27_RS01760	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY27_RS01770	COG3079	Belongs to the UPF0149 family
GPY27_RS01775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY27_RS01780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY27_RS01795	COG0354	folic acid binding
GPY27_RS01800	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY27_RS01810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY27_RS01820	COG1595	DNA-templated transcription, initiation
GPY27_RS01825	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPY27_RS01835	COG3086	response to oxidative stress
GPY27_RS01840	COG0481	GTPase activity
GPY27_RS01845	COG0681	Belongs to the peptidase S26 family
GPY27_RS01850	COG0571	ribonuclease III activity
GPY27_RS01855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY27_RS01860	COG1381	Involved in DNA repair and RecF pathway recombination
GPY27_RS01865	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY27_RS01870	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY27_RS01880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY27_RS01890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY27_RS01895	COG3956	TIGRFAM MazG family protein
GPY27_RS01900	COG0504	CTP synthase activity
GPY27_RS01905	COG0148	phosphopyruvate hydratase activity
GPY27_RS01910	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY27_RS01915	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY27_RS01920	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY27_RS01925	COG0585	pseudouridine synthase activity
GPY27_RS01930	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY27_RS01935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY27_RS01950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY27_RS01955	COG1546	Belongs to the CinA family
GPY27_RS01960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY27_RS01965	COG2137	regulation of response to DNA damage stimulus
GPY27_RS01970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY27_RS01975	COG0527	aspartate kinase activity
GPY27_RS02035	COG3630	sodium ion export across plasma membrane
GPY27_RS02040	COG0511	ligase activity, forming carbon-carbon bonds
GPY27_RS02040	COG5016	pyruvate
GPY27_RS02045	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY27_RS02050	COG1063	alcohol dehydrogenase
GPY27_RS02055	COG1238	metal cluster binding
GPY27_RS02060	COG0612	Peptidase, M16
GPY27_RS02065	COG2918	glutathione biosynthetic process
GPY27_RS02075	COG1854	S-ribosylhomocysteine lyase activity
GPY27_RS02080	COG4536	flavin adenine dinucleotide binding
GPY27_RS02085	COG4137	Cytochrome C assembly protein
GPY27_RS02090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY27_RS02095	COG0228	four-way junction DNA binding
GPY27_RS02100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY27_RS02105	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY27_RS02110	COG0335	large ribosomal subunit rRNA binding
GPY27_RS02115	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY27_RS02120	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY27_RS02125	COG0237	dephospho-CoA kinase activity
GPY27_RS02135	COG1459	type II secretion system
GPY27_RS02140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY27_RS02150	COG0157	Belongs to the NadC ModD family
GPY27_RS02160	COG2186	Transcriptional regulator
GPY27_RS02165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY27_RS02170	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY27_RS02175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY27_RS02190	COG0288	reversible hydration of carbon dioxide
GPY27_RS02195	COG0659	secondary active sulfate transmembrane transporter activity
GPY27_RS02205	COG1131	(ABC) transporter
GPY27_RS02210	COG0842	Transport permease protein
GPY27_RS02225	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY27_RS02230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY27_RS02235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY27_RS02250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY27_RS02260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY27_RS02265	COG1489	DNA binding
GPY27_RS02270	COG1643	Atp-dependent helicase
GPY27_RS02275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY27_RS02280	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY27_RS02285	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY27_RS02290	COG3112	Uncharacterised protein family (UPF0231)
GPY27_RS02300	COG0004	ammonium transporteR
GPY27_RS02305	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY27_RS02315	COG3842	ATPase activity
GPY27_RS02320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY27_RS02335	COG2971	BadF BadG BcrA BcrD
GPY27_RS02345	COG4608	Belongs to the ABC transporter superfamily
GPY27_RS02350	COG0444	Belongs to the ABC transporter superfamily
GPY27_RS02355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY27_RS02365	COG0747	negative chemotaxis
GPY27_RS02370	COG0784	Response regulator, receiver
GPY27_RS02370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY27_RS02370	COG2198	Histidine kinase
GPY27_RS02370	COG2205	protein histidine kinase activity
GPY27_RS02375	COG2813	Specifically methylates the guanine in position
GPY27_RS02380	COG0628	permease
GPY27_RS02385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY27_RS02390	COG0316	Belongs to the HesB IscA family
GPY27_RS02400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY27_RS02405	COG0739	heme binding
GPY27_RS02410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY27_RS02420	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY27_RS02425	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY27_RS02430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY27_RS02435	COG1534	Rna-binding protein
GPY27_RS02440	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY27_RS02445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY27_RS02450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY27_RS02455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY27_RS02465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY27_RS02480	COG0779	Required for maturation of 30S ribosomal subunits
GPY27_RS02485	COG0195	Participates in both transcription termination and antitermination
GPY27_RS02490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY27_RS02495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY27_RS02500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY27_RS02505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY27_RS02510	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY27_RS02525	COG0534	Mate efflux family protein
GPY27_RS02550	COG3153	acetyltransferase
GPY27_RS02570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY27_RS02580	COG0084	hydrolase, TatD family'
GPY27_RS02585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY27_RS02590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY27_RS02595	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY27_RS02600	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY27_RS02605	COG0813	purine-nucleoside phosphorylase activity
GPY27_RS02615	COG0560	Phosphoserine phosphatase
GPY27_RS02625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY27_RS02630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY27_RS02635	COG0583	DNA-binding transcription factor activity
GPY27_RS02645	COG1022	Amp-dependent synthetase and ligase
GPY27_RS02650	COG2169	Transcriptional regulator
GPY27_RS02675	COG4964	Belongs to the GSP D family
GPY27_RS02735	COG0583	DNA-binding transcription factor activity
GPY27_RS02740	COG0531	amino acid
GPY27_RS02745	COG2731	YhcH YjgK YiaL family protein
GPY27_RS02750	COG3250	beta-galactosidase activity
GPY27_RS02755	COG1609	Transcriptional regulator
GPY27_RS02770	COG1085	galactose-1-phosphate uridylyltransferase
GPY27_RS02775	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY27_RS02780	COG2017	converts alpha-aldose to the beta-anomer
GPY27_RS02795	COG2176	DNA-directed DNA polymerase activity
GPY27_RS02800	COG1609	Transcriptional regulator
GPY27_RS02805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY27_RS02825	COG0598	Magnesium transport protein CorA
GPY27_RS02830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY27_RS02835	COG1349	DNA-binding transcription factor activity
GPY27_RS02840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY27_RS02845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY27_RS02860	COG2271	Major facilitator Superfamily
GPY27_RS02865	COG0584	glycerophosphoryl diester phosphodiesterase
GPY27_RS02870	COG2171	N-acyltransferase activity
GPY27_RS02875	COG3141	response to X-ray
GPY27_RS02895	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY27_RS02900	COG1074	ATP-dependent DNA helicase activity
GPY27_RS02905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY27_RS02915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY27_RS02915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY27_RS02925	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY27_RS02930	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY27_RS02935	COG2166	iron-sulfur cluster assembly
GPY27_RS02940	COG3706	GGDEF domain
GPY27_RS02945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY27_RS02950	COG0693	protein deglycase activity
GPY27_RS02955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY27_RS02985	COG1595	DNA-templated transcription, initiation
GPY27_RS03005	COG3056	Lipoprotein
GPY27_RS03010	COG2813	Specifically methylates the guanine in position
GPY27_RS03015	COG0271	Belongs to the BolA IbaG family
GPY27_RS03020	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY27_RS03025	COG1805	sodium ion transport
GPY27_RS03030	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY27_RS03035	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY27_RS03040	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY27_RS03045	COG2871	sodium ion transport
GPY27_RS03065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY27_RS03070	COG0514	ATP-dependent DNA helicase (RecQ)
GPY27_RS03075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY27_RS03090	COG0733	neurotransmitter:sodium symporter activity
GPY27_RS03110	COG0442	prolyl-tRNA aminoacylation
GPY27_RS03115	COG1720	tRNA m6t6A37 methyltransferase activity
GPY27_RS03120	COG0254	rRNA binding
GPY27_RS03135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY27_RS03140	COG1671	Belongs to the UPF0178 family
GPY27_RS03165	COG3098	single-species biofilm formation
GPY27_RS03170	COG0564	pseudouridine synthase activity
GPY27_RS03180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY27_RS03185	COG0024	Methionine aminopeptidase
GPY27_RS03190	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY27_RS03195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY27_RS03200	COG0528	UMP kinase activity
GPY27_RS03205	COG0233	cytoplasmic translational termination
GPY27_RS03210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY27_RS03215	COG0575	Belongs to the CDS family
GPY27_RS03220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY27_RS03225	COG0750	zinc metalloprotease
GPY27_RS03235	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY27_RS03240	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY27_RS03245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY27_RS03250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY27_RS03255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY27_RS03260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPY27_RS03265	COG0587	DNA-directed DNA polymerase activity
GPY27_RS03270	COG0825	malonyl-CoA metabolic process
GPY27_RS03275	COG0037	tRNA processing
GPY27_RS03285	COG0347	Belongs to the P(II) protein family
GPY27_RS03290	COG3021	interspecies interaction between organisms
GPY27_RS03300	COG1388	LysM domain
GPY27_RS03300	COG0741	lytic transglycosylase activity
GPY27_RS03305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY27_RS03310	COG2226	methyltransferase
GPY27_RS03315	COG0328	RNA-DNA hybrid ribonuclease activity
GPY27_RS03320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY27_RS03340	COG0456	acetyltransferase
GPY27_RS03350	COG1960	acyl-CoA dehydrogenase activity
GPY27_RS03355	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY27_RS03360	COG0121	glutamine amidotransferase
GPY27_RS03365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY27_RS03370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY27_RS03375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY27_RS03380	COG2233	PERMEase
GPY27_RS03400	COG1393	Belongs to the ArsC family
GPY27_RS03405	COG4783	chaperone-mediated protein folding
GPY27_RS03420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY27_RS03425	COG2716	regulation of RNA biosynthetic process
GPY27_RS03430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY27_RS03450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY27_RS03455	COG1393	Belongs to the ArsC family
GPY27_RS03485	COG2837	iron assimilation
GPY27_RS03490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY27_RS03500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY27_RS03505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY27_RS03510	COG1334	flagellar protein FlaG
GPY27_RS03515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY27_RS03525	COG1516	flagellar protein fliS
GPY27_RS03535	COG4191	Histidine kinase
GPY27_RS03540	COG2204	response regulator
GPY27_RS03545	COG1677	Flagellar hook-basal body complex protein FliE
GPY27_RS03555	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY27_RS03605	COG1987	bacterial-type flagellum assembly
GPY27_RS03630	COG0455	bacterial-type flagellum organization
GPY27_RS03645	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY27_RS03650	COG0643	Histidine kinase
GPY27_RS03650	COG2198	Histidine kinase
GPY27_RS03655	COG2201	protein-glutamate methylesterase activity
GPY27_RS03660	COG1192	Involved in chromosome partitioning
GPY27_RS03670	COG0835	chemotaxis
GPY27_RS03680	COG4133	protoheme IX ABC transporter activity
GPY27_RS03685	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY27_RS03690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY27_RS03695	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY27_RS03700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY27_RS03705	COG1138	Cytochrome C-type biogenesis protein
GPY27_RS03710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY27_RS03725	COG2853	Lipoprotein
GPY27_RS03730	COG2067	long-chain fatty acid transport protein
GPY27_RS03735	COG2067	long-chain fatty acid transport protein
GPY27_RS03750	COG0183	Belongs to the thiolase family
GPY27_RS03755	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY27_RS03755	COG1024	Enoyl-CoA hydratase
GPY27_RS03770	COG2062	phosphohistidine phosphatase, SixA
GPY27_RS03775	COG2840	Smr protein MutS2
GPY27_RS03780	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY27_RS03785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY27_RS03790	COG2860	membrane
GPY27_RS03800	COG3101	peptidyl-lysine hydroxylation
GPY27_RS03815	COG0431	NADPH-dependent FMN reductase
GPY27_RS03820	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY27_RS03820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY27_RS03825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY27_RS03830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY27_RS03835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY27_RS03845	COG0101	tRNA pseudouridine synthase activity
GPY27_RS03850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY27_RS03855	COG0285	dihydrofolate synthase activity
GPY27_RS03860	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY27_RS03865	COG1286	toxin biosynthetic process
GPY27_RS03870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY27_RS03875	COG0583	DNA-binding transcription factor activity
GPY27_RS03880	COG0745	RESPONSE REGULATOR receiver
GPY27_RS03890	COG2832	Protein of unknown function (DUF454)
GPY27_RS03895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY27_RS03905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY27_RS03910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY27_RS03915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY27_RS03920	COG0814	amino acid
GPY27_RS03925	COG0251	oxidation-reduction process
GPY27_RS03930	COG3681	Belongs to the UPF0597 family
GPY27_RS03945	COG2261	transglycosylase associated protein
GPY27_RS03950	COG2983	Belongs to the UPF0260 family
GPY27_RS03955	COG0668	transmembrane transport
GPY27_RS03965	COG0346	lactoylglutathione lyase activity
GPY27_RS03975	COG1785	Belongs to the alkaline phosphatase family
GPY27_RS03995	COG2226	methyltransferase
GPY27_RS04010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY27_RS04015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY27_RS04025	COG3139	Protein of unknown function (DUF1315)
GPY27_RS04030	COG0252	asparaginase activity
GPY27_RS04035	COG0616	signal peptide processing
GPY27_RS04040	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY27_RS04040	COG1902	pentaerythritol trinitrate reductase activity
GPY27_RS04045	COG0778	Nitroreductase
GPY27_RS04070	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY27_RS04080	COG3083	sulfuric ester hydrolase activity
GPY27_RS04085	COG3082	Protein of unknown function (DUF1414)
GPY27_RS04090	COG3081	Nucleoid-associated protein
GPY27_RS04105	COG1757	Na H antiporter
GPY27_RS04110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY27_RS04115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY27_RS04120	COG2095	MarC family integral membrane protein
GPY27_RS04125	COG1454	alcohol dehydrogenase
GPY27_RS04125	COG1012	belongs to the aldehyde dehydrogenase family
GPY27_RS04145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY27_RS04155	COG2056	Na+-H+ antiporter family
GPY27_RS04160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY27_RS04175	COG2885	chlorophyll binding
GPY27_RS04185	COG0346	lactoylglutathione lyase activity
GPY27_RS04190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY27_RS04195	COG4660	Part of a membrane complex involved in electron transport
GPY27_RS04200	COG4659	FMN binding
GPY27_RS04205	COG4658	electron transport chain
GPY27_RS04210	COG4656	Part of a membrane complex involved in electron transport
GPY27_RS04215	COG2878	Part of a membrane complex involved in electron transport
GPY27_RS04220	COG4657	Part of a membrane complex involved in electron transport
GPY27_RS04235	COG0556	nucleotide-excision repair
GPY27_RS04240	COG2204	response regulator
GPY27_RS04245	COG2198	Histidine kinase
GPY27_RS04250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY27_RS04255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY27_RS04260	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY27_RS04265	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY27_RS04270	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY27_RS04275	COG0314	molybdopterin synthase activity
GPY27_RS04285	COG0601	transmembrane transport
GPY27_RS04290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY27_RS04295	COG0444	Belongs to the ABC transporter superfamily
GPY27_RS04305	COG0435	Glutathione S-transferase
GPY27_RS04315	COG3174	membrane
GPY27_RS04320	COG0857	belongs to the CobB CobQ family
GPY27_RS04320	COG0280	phosphate acetyltransferase
GPY27_RS04325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY27_RS04330	COG3092	negative regulation of chromosome organization
GPY27_RS04340	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY27_RS04345	COG1122	ATPase activity
GPY27_RS04350	COG0366	Alpha amylase catalytic
GPY27_RS04355	COG3706	GGDEF domain
GPY27_RS04355	COG0745	RESPONSE REGULATOR receiver
GPY27_RS04360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY27_RS04365	COG0653	protein targeting
GPY27_RS04370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY27_RS04375	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY27_RS04380	COG2186	Transcriptional regulator
GPY27_RS04390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY27_RS04390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY27_RS04395	COG0489	protein tyrosine kinase activity
GPY27_RS04400	COG0572	uridine kinase
GPY27_RS04410	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY27_RS04415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY27_RS04420	COG0659	secondary active sulfate transmembrane transporter activity
GPY27_RS04425	COG1530	ribonuclease E activity
GPY27_RS04430	COG0564	pseudouridine synthase activity
GPY27_RS04435	COG0424	maF-like protein
GPY27_RS04440	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY27_RS04450	COG0416	fatty acid biosynthetic process
GPY27_RS04455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY27_RS04485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY27_RS04490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY27_RS04500	COG0084	hydrolase, TatD family'
GPY27_RS04505	COG1263	PTS System
GPY27_RS04505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY27_RS04525	COG0733	neurotransmitter:sodium symporter activity
GPY27_RS04540	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY27_RS04545	COG0469	pyruvate kinase activity
GPY27_RS04550	COG1940	carbohydrate kinase activity
GPY27_RS04555	COG0835	chemotaxis
GPY27_RS04555	COG0784	Response regulator, receiver
GPY27_RS04560	COG0587	DNA-directed DNA polymerase activity
GPY27_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS04580	COG0616	signal peptide processing
GPY27_RS04585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY27_RS04590	COG0539	negative regulation of cytoplasmic translation
GPY27_RS04600	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY27_RS04605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY27_RS04610	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY27_RS04615	COG4166	transmembrane transport
GPY27_RS04640	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY27_RS04650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY27_RS04650	COG3008	intermembrane lipid transfer
GPY27_RS04655	COG2995	paraquat-inducible protein a
GPY27_RS04660	COG3258	Cytochrome c
GPY27_RS04665	COG2863	cytochrome
GPY27_RS04705	COG4232	protein-disulfide reductase activity
GPY27_RS04710	COG3118	belongs to the thioredoxin family
GPY27_RS04740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY27_RS04750	COG0577	efflux transmembrane transporter activity
GPY27_RS04750	COG1136	(ABC) transporter
GPY27_RS04755	COG0577	efflux transmembrane transporter activity
GPY27_RS04755	COG1136	(ABC) transporter
GPY27_RS04760	COG0577	efflux transmembrane transporter activity
GPY27_RS04760	COG1136	(ABC) transporter
GPY27_RS04765	COG1335	isochorismatase
GPY27_RS04780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY27_RS04815	COG5002	protein histidine kinase activity
GPY27_RS04815	COG3850	Histidine kinase
GPY27_RS04820	COG0745	RESPONSE REGULATOR receiver
GPY27_RS04830	COG0840	transmembrane signaling receptor activity
GPY27_RS04835	COG1032	radical SAM domain protein
GPY27_RS04840	COG3706	GGDEF domain
GPY27_RS04840	COG4251	negative regulation of phosphorylation
GPY27_RS04840	COG2203	Gaf domain
GPY27_RS04840	COG5001	Diguanylate cyclase
GPY27_RS04855	COG0583	DNA-binding transcription factor activity
GPY27_RS04865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY27_RS04875	COG2350	Protein conserved in bacteria
GPY27_RS04880	COG1607	acyl-coa hydrolase
GPY27_RS04885	COG2917	probably involved in intracellular septation
GPY27_RS04905	COG1301	dicarboxylic acid transport
GPY27_RS04915	COG0318	PFAM AMP-dependent synthetase and ligase
GPY27_RS04920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY27_RS04930	COG0159	tryptophan synthase activity
GPY27_RS04935	COG0133	tryptophan synthase activity
GPY27_RS04940	COG0135	phosphoribosylanthranilate isomerase activity
GPY27_RS04940	COG0134	indole-3-glycerol-phosphate synthase activity
GPY27_RS04945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY27_RS04950	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY27_RS04955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY27_RS04965	COG0613	PHP domain protein
GPY27_RS04970	COG0009	L-threonylcarbamoyladenylate synthase
GPY27_RS04980	COG1187	pseudouridine synthase activity
GPY27_RS04990	COG3099	Belongs to the UPF0263 family
GPY27_RS04995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY27_RS05005	COG0417	DNA replication proofreading
GPY27_RS05010	COG2197	response regulator
GPY27_RS05015	COG0322	excinuclease ABC activity
GPY27_RS05055	COG0019	diaminopimelate decarboxylase activity
GPY27_RS05080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY27_RS05085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY27_RS05090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY27_RS05110	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY27_RS05120	COG0437	4 iron, 4 sulfur cluster binding
GPY27_RS05125	COG3301	Polysulphide reductase, NrfD
GPY27_RS05130	COG1138	Cytochrome C-type biogenesis protein
GPY27_RS05140	COG4235	cytochrome complex assembly
GPY27_RS05140	COG3088	subunit of a heme lyase
GPY27_RS05150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY27_RS05175	COG2989	Protein conserved in bacteria
GPY27_RS05180	COG3108	Peptidase M15
GPY27_RS05185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY27_RS05200	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY27_RS05225	COG1846	Transcriptional regulator
GPY27_RS05230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY27_RS05235	COG0840	transmembrane signaling receptor activity
GPY27_RS05255	COG1448	Aminotransferase
GPY27_RS05280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY27_RS05290	COG0017	Asparaginyl-tRNA synthetase
GPY27_RS05300	COG0720	synthase
GPY27_RS05310	COG2200	EAL domain
GPY27_RS05315	COG1760	l-serine dehydratase
GPY27_RS05320	COG0814	amino acid
GPY27_RS05325	COG0494	nUDIX hydrolase
GPY27_RS05335	COG2205	protein histidine kinase activity
GPY27_RS05335	COG0784	Response regulator, receiver
GPY27_RS05340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY27_RS05360	COG3106	COG3106 Predicted ATPase
GPY27_RS05365	COG3768	UPF0283 membrane protein
GPY27_RS05375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY27_RS05545	COG0456	acetyltransferase
GPY27_RS05720	COG4628	conserved protein (DUF2132)
GPY27_RS05815	COG0346	lactoylglutathione lyase activity
GPY27_RS06020	COG1757	Na H antiporter
GPY27_RS06025	COG0174	glutamine synthetase
GPY27_RS06035	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY27_RS06040	COG1917	Cupin 2, conserved barrel domain protein
GPY27_RS06040	COG1396	sequence-specific DNA binding
GPY27_RS06045	COG1012	belongs to the aldehyde dehydrogenase family
GPY27_RS06050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY27_RS06060	COG2957	Belongs to the agmatine deiminase family
GPY27_RS06065	COG1012	belongs to the aldehyde dehydrogenase family
GPY27_RS06070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY27_RS06075	COG1227	inorganic diphosphatase activity
GPY27_RS06085	COG2200	EAL domain
GPY27_RS06085	COG2771	luxR family
GPY27_RS06095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY27_RS06110	COG1846	Transcriptional regulator
GPY27_RS06115	COG2315	Protein conserved in bacteria
GPY27_RS06135	COG0110	maltose O-acetyltransferase activity
GPY27_RS06150	COG2205	protein histidine kinase activity
GPY27_RS06150	COG4999	Histidine kinase
GPY27_RS06150	COG3437	response regulator, receiver
GPY27_RS06150	COG3850	Histidine kinase
GPY27_RS06165	COG3063	Type IV pilus biogenesis stability protein PilW
GPY27_RS06170	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY27_RS06185	COG0531	amino acid
GPY27_RS06195	COG1560	Kdo2-lipid A biosynthetic process
GPY27_RS06200	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY27_RS06205	COG1280	lysine exporter protein (LysE YggA)
GPY27_RS06215	COG1115	amino acid carrier protein
GPY27_RS06240	COG1368	sulfuric ester hydrolase activity
GPY27_RS06245	COG0642	Histidine kinase
GPY27_RS06250	COG0745	RESPONSE REGULATOR receiver
GPY27_RS06260	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS06280	COG2113	Glycine betaine
GPY27_RS06285	COG4176	ABC-type proline glycine betaine transport system permease component
GPY27_RS06305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY27_RS06310	COG0456	acetyltransferase
GPY27_RS06315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY27_RS06320	COG0662	Cupin 2, conserved barrel domain protein
GPY27_RS06325	COG0527	aspartate kinase activity
GPY27_RS06330	COG1858	cytochrome C peroxidase
GPY27_RS06345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY27_RS06360	COG3290	protein histidine kinase activity
GPY27_RS06365	COG4565	transcriptional regulatory protein
GPY27_RS06370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY27_RS06375	COG0363	glucosamine-6-phosphate deaminase activity
GPY27_RS06380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY27_RS06400	COG3284	Transcriptional regulator
GPY27_RS06405	COG1012	belongs to the aldehyde dehydrogenase family
GPY27_RS06475	COG4669	(LipO)protein
GPY27_RS06495	COG3177	Filamentation induced by cAMP protein fic
GPY27_RS06535	COG1073	alpha beta
GPY27_RS06540	COG1073	alpha beta
GPY27_RS06550	COG4792	protein secretion
GPY27_RS06555	COG4791	protein targeting
GPY27_RS06560	COG4794	Type iii secretion
GPY27_RS06565	COG4790	Type iii secretion
GPY27_RS06570	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY27_RS06635	COG0457	Tetratricopeptide repeat
GPY27_RS06655	COG0730	response to heat
GPY27_RS06685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY27_RS06690	COG0372	Belongs to the citrate synthase family
GPY27_RS06700	COG2828	Protein conserved in bacteria
GPY27_RS06725	COG0561	phosphatase activity
GPY27_RS06730	COG0602	queuosine metabolic process
GPY27_RS06735	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY27_RS06740	COG3706	GGDEF domain
GPY27_RS06780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY27_RS06785	COG0840	transmembrane signaling receptor activity
GPY27_RS06790	COG1254	Belongs to the acylphosphatase family
GPY27_RS06795	COG2920	part of a sulfur-relay system
GPY27_RS06805	COG0670	Belongs to the BI1 family
GPY27_RS06810	COG1126	abc transporter atp-binding protein
GPY27_RS06815	COG0765	amino acid transport
GPY27_RS06820	COG4597	amino acid ABC transporter
GPY27_RS06825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY27_RS06840	COG1666	GTP binding
GPY27_RS06845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY27_RS06865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY27_RS06865	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY27_RS06870	COG3008	intermembrane lipid transfer
GPY27_RS06875	COG2995	paraquat-inducible protein a
GPY27_RS06880	COG1132	(ABC) transporter
GPY27_RS06885	COG1956	GAF domain-containing protein
GPY27_RS06890	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY27_RS06905	COG0308	aminopeptidase N
GPY27_RS06920	COG0167	dihydroorotate dehydrogenase activity
GPY27_RS06935	COG0116	Belongs to the methyltransferase superfamily
GPY27_RS06935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY27_RS06960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY27_RS06965	COG1067	ATP-dependent peptidase activity
GPY27_RS06970	COG3120	sequence-specific DNA binding
GPY27_RS07020	COG4128	Pfam Zonular occludens toxin
GPY27_RS07205	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY27_RS07220	COG2010	Cytochrome c
GPY27_RS07230	COG2217	Heavy metal translocating P-type atpase
GPY27_RS07245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY27_RS07250	COG0589	response to stress
GPY27_RS07260	COG0037	tRNA processing
GPY27_RS07280	COG3842	ATPase activity
GPY27_RS07285	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY27_RS07290	COG1177	transmembrane transport
GPY27_RS07295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY27_RS07300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY27_RS07305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY27_RS07315	COG0004	ammonium transporteR
GPY27_RS07340	COG0437	4 iron, 4 sulfur cluster binding
GPY27_RS07345	COG0243	molybdopterin cofactor binding
GPY27_RS07345	COG3383	formate dehydrogenase (NAD+) activity
GPY27_RS07355	COG3381	protein complex oligomerization
GPY27_RS07380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY27_RS07385	COG0488	(ABC) transporter
GPY27_RS07395	COG4191	Histidine kinase
GPY27_RS07400	COG2204	response regulator
GPY27_RS07420	COG3842	ATPase activity
GPY27_RS07425	COG0746	molybdenum cofactor guanylyltransferase activity
GPY27_RS07430	COG0303	'Molybdopterin
GPY27_RS07440	COG1940	carbohydrate kinase activity
GPY27_RS07480	COG0840	transmembrane signaling receptor activity
GPY27_RS07480	COG3290	protein histidine kinase activity
GPY27_RS07485	COG0791	NLP P60 protein
GPY27_RS07495	COG3706	GGDEF domain
GPY27_RS07500	COG2201	protein-glutamate methylesterase activity
GPY27_RS07515	COG0307	riboflavin synthase, alpha
GPY27_RS07520	COG0534	Mate efflux family protein
GPY27_RS07530	COG1793	dna ligase
GPY27_RS07565	COG2204	response regulator
GPY27_RS07610	COG0438	transferase activity, transferring glycosyl groups
GPY27_RS07615	COG1215	transferase activity, transferring glycosyl groups
GPY27_RS07620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY27_RS07630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY27_RS07645	COG1643	Atp-dependent helicase
GPY27_RS07650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY27_RS07660	COG3381	protein complex oligomerization
GPY27_RS07665	COG3302	dmso reductase anchor subunit
GPY27_RS07670	COG0437	4 iron, 4 sulfur cluster binding
GPY27_RS07675	COG0243	molybdopterin cofactor binding
GPY27_RS07705	COG3706	GGDEF domain
GPY27_RS07715	COG0443	Heat shock 70 kDa protein
GPY27_RS07720	COG0443	Heat shock 70 kDa protein
GPY27_RS07750	COG1132	(ABC) transporter
GPY27_RS07755	COG1132	(ABC) transporter
GPY27_RS07780	COG0814	amino acid
GPY27_RS07795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY27_RS07880	COG1522	sequence-specific DNA binding
GPY27_RS07915	COG0515	serine threonine protein kinase
GPY27_RS07940	COG3501	Rhs element vgr protein
GPY27_RS07980	COG0739	heme binding
GPY27_RS07985	COG0861	Integral membrane protein TerC family
GPY27_RS07995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY27_RS08000	COG1328	CTP reductase activity
GPY27_RS08005	COG1280	lysine exporter protein (LysE YggA)
GPY27_RS08015	COG3300	MHYT domain
GPY27_RS08015	COG5001	Diguanylate cyclase
GPY27_RS08025	COG4191	Histidine kinase
GPY27_RS08025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY27_RS08030	COG0471	metal ion transport
GPY27_RS08065	COG0583	DNA-binding transcription factor activity
GPY27_RS08070	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY27_RS08125	COG1280	lysine exporter protein (LysE YggA)
GPY27_RS08280	COG1783	phage Terminase large subunit
GPY27_RS08290	COG1475	DNA binding
GPY27_RS08330	COG0557	exoribonuclease II activity
GPY27_RS08335	COG1278	Cold shock
GPY27_RS08440	COG0625	glutathione transferase activity
GPY27_RS08450	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY27_RS08460	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY27_RS08470	COG0601	transmembrane transport
GPY27_RS08475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY27_RS08480	COG0444	Belongs to the ABC transporter superfamily
GPY27_RS08500	COG3291	Pkd domain containing protein
GPY27_RS08510	COG1177	transmembrane transport
GPY27_RS08515	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY27_RS08520	COG3842	ATPase activity
GPY27_RS08525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY27_RS08530	COG2423	ornithine cyclodeaminase activity
GPY27_RS08550	COG3938	Belongs to the proline racemase family
GPY27_RS08580	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GPY27_RS08585	COG1451	nucleotide metabolic process
GPY27_RS08590	COG3475	LICD family
GPY27_RS08595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY27_RS08600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY27_RS08620	COG0583	DNA-binding transcription factor activity
GPY27_RS08640	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY27_RS08645	COG4139	cobalamin transport
GPY27_RS08650	COG2988	succinylglutamate desuccinylase activity
GPY27_RS08675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY27_RS08680	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY27_RS08685	COG0702	epimerase
GPY27_RS08695	COG2925	Exonuclease
GPY27_RS08700	COG1380	Effector of murein hydrolase LrgA
GPY27_RS08705	COG1346	cytolysis
GPY27_RS08710	COG0295	cytidine deaminase activity
GPY27_RS08715	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY27_RS08720	COG0500	methyltransferase
GPY27_RS08730	COG0776	regulation of translation
GPY27_RS08745	COG0072	phenylalanine-tRNA ligase activity
GPY27_RS08745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY27_RS08750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY27_RS08755	COG3706	GGDEF domain
GPY27_RS08785	COG0393	Putative heavy-metal-binding
GPY27_RS08795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY27_RS08805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY27_RS08820	COG2188	Transcriptional regulator
GPY27_RS08825	COG1228	amidohydrolase
GPY27_RS08830	COG0010	Belongs to the arginase family
GPY27_RS08835	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY27_RS08840	COG2986	histidine ammonia-lyase
GPY27_RS08855	COG0277	FAD linked oxidase domain protein
GPY27_RS08855	COG0247	lactate metabolic process
GPY27_RS08890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY27_RS08905	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GPY27_RS08910	COG1643	Atp-dependent helicase
GPY27_RS08915	COG0281	malic enzyme
GPY27_RS08920	COG2949	membrane
GPY27_RS08925	COG0471	metal ion transport
GPY27_RS08930	COG3706	GGDEF domain
GPY27_RS08930	COG0745	RESPONSE REGULATOR receiver
GPY27_RS08950	COG0492	ferredoxin-NADP+ reductase activity
GPY27_RS08955	COG4988	ABC transporter
GPY27_RS08960	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY27_RS08965	COG3048	D-serine ammonia-lyase activity
GPY27_RS08970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY27_RS08980	COG4191	Histidine kinase
GPY27_RS08980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY27_RS08995	COG3070	regulator of competence-specific genes
GPY27_RS09010	COG2431	L-lysine efflux transmembrane transporter activity
GPY27_RS09020	COG0076	glutamate decarboxylase activity
GPY27_RS09025	COG1737	Transcriptional regulator
GPY27_RS09040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY27_RS09045	COG3273	potassium ion transport
GPY27_RS09045	COG2985	domain, Protein
GPY27_RS09050	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY27_RS09065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY27_RS09080	COG1136	(ABC) transporter
GPY27_RS09090	COG0702	epimerase
GPY27_RS09095	COG3005	denitrification pathway
GPY27_RS09125	COG2814	Major facilitator Superfamily
GPY27_RS09130	COG1187	pseudouridine synthase activity
GPY27_RS09135	COG1061	Type III restriction enzyme res subunit
GPY27_RS09145	COG0745	RESPONSE REGULATOR receiver
GPY27_RS09150	COG2205	protein histidine kinase activity
GPY27_RS09155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY27_RS09185	COG3313	Fe-S protein
GPY27_RS09210	COG0493	'glutamate synthase
GPY27_RS09225	COG4134	Bacterial extracellular solute-binding protein
GPY27_RS09230	COG4135	transport system, permease component
GPY27_RS09235	COG4136	ATPase activity
GPY27_RS09240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY27_RS09255	COG3604	Transcriptional regulator
GPY27_RS09260	COG1151	hydroxylamine reductase activity
GPY27_RS09265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY27_RS09275	COG0564	pseudouridine synthase activity
GPY27_RS09285	COG0733	neurotransmitter:sodium symporter activity
GPY27_RS09295	COG0626	cystathionine gamma-synthase activity
GPY27_RS09300	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY27_RS09305	COG5380	lipid catabolic process
GPY27_RS09310	COG2818	Glycosylase
GPY27_RS09325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY27_RS09330	COG1983	PspC domain protein
GPY27_RS09340	COG1842	Phage shock protein A
GPY27_RS09345	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY27_RS09355	COG4168	peptide transport system, permease
GPY27_RS09360	COG4171	peptide transport system, permease
GPY27_RS09370	COG4172	Belongs to the ABC transporter superfamily
GPY27_RS09380	COG1227	inorganic diphosphatase activity
GPY27_RS09395	COG0243	molybdopterin cofactor binding
GPY27_RS09400	COG3005	denitrification pathway
GPY27_RS09405	COG4459	periplasmic nitrate reductase
GPY27_RS09410	COG0390	transport system, permease component
GPY27_RS09420	COG2116	formate transmembrane transporter activity
GPY27_RS09445	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY27_RS09450	COG1435	thymidine kinase activity
GPY27_RS09455	COG0215	cysteine-tRNA ligase activity
GPY27_RS09460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY27_RS09465	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY27_RS09470	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY27_RS09480	COG3012	SEC-C Motif Domain Protein
GPY27_RS09485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY27_RS09485	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY27_RS09490	COG0107	imidazoleglycerol-phosphate synthase activity
GPY27_RS09495	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY27_RS09500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY27_RS09505	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY27_RS09505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY27_RS09510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY27_RS09515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY27_RS09520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY27_RS09535	COG1757	Na H antiporter
GPY27_RS09545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY27_RS09555	COG0482	sulfurtransferase activity
GPY27_RS09560	COG2915	High frequency lysogenization protein hflD homolog
GPY27_RS09565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY27_RS09590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY27_RS09605	COG0300	oxidoreductase activity
GPY27_RS09615	COG0501	Belongs to the peptidase M48B family
GPY27_RS09625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY27_RS09635	COG0156	8-amino-7-oxononanoate synthase activity
GPY27_RS09640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY27_RS09645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY27_RS09650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY27_RS09660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY27_RS09665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY27_RS09670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY27_RS09675	COG1674	ftsk spoiiie
GPY27_RS09685	COG0686	Belongs to the AlaDH PNT family
GPY27_RS09695	COG0583	DNA-binding transcription factor activity
GPY27_RS09710	COG3568	Endonuclease Exonuclease Phosphatase
GPY27_RS09740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY27_RS09745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY27_RS09760	COG0840	transmembrane signaling receptor activity
GPY27_RS09775	COG0784	Response regulator, receiver
GPY27_RS09775	COG5002	protein histidine kinase activity
GPY27_RS09785	COG0754	glutathionylspermidine amidase activity
GPY27_RS09795	COG3766	membrane
GPY27_RS09805	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY27_RS09810	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY27_RS09815	COG2885	chlorophyll binding
GPY27_RS09820	COG0823	Involved in the tonB-independent uptake of proteins
GPY27_RS09835	COG0811	peptide transport
GPY27_RS09840	COG0824	Thioesterase
GPY27_RS09850	COG4890	Cyd operon protein YbgT
GPY27_RS09855	COG1294	oxidase, subunit
GPY27_RS09860	COG1271	oxidase subunit
GPY27_RS09865	COG2255	four-way junction helicase activity
GPY27_RS09870	COG0632	four-way junction helicase activity
GPY27_RS09875	COG0840	transmembrane signaling receptor activity
GPY27_RS09880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY27_RS09885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY27_RS09890	COG1801	Protein of unknown function DUF72
GPY27_RS09895	COG4106	trans-aconitate 2-methyltransferase activity
GPY27_RS09900	COG0500	methyltransferase
GPY27_RS09910	COG4067	protein conserved in archaea
GPY27_RS09910	COG0189	ligase activity
GPY27_RS09930	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY27_RS09935	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY27_RS09940	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY27_RS09945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY27_RS09950	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY27_RS09955	COG0745	RESPONSE REGULATOR receiver
GPY27_RS09960	COG3381	protein complex oligomerization
GPY27_RS09965	COG1609	Transcriptional regulator
GPY27_RS09970	COG3070	regulator of competence-specific genes
GPY27_RS09990	COG0297	glycogen (starch) synthase activity
GPY27_RS09995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY27_RS10000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY27_RS10010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY27_RS10020	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY27_RS10025	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY27_RS10030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY27_RS10040	COG0542	response to heat
GPY27_RS10045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY27_RS10050	COG1278	Cold shock
GPY27_RS10060	COG1187	pseudouridine synthase activity
GPY27_RS10065	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY27_RS10075	COG1199	ATP-dependent helicase activity
GPY27_RS10080	COG0730	response to heat
GPY27_RS10085	COG3923	Primosomal replication protein n
GPY27_RS10095	COG0708	Exodeoxyribonuclease III
GPY27_RS10110	COG4215	(ABC) transporter
GPY27_RS10140	COG1882	Formate acetyltransferase
GPY27_RS10150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY27_RS10160	COG3013	Belongs to the UPF0304 family
GPY27_RS10170	COG2766	serine protein kinase
GPY27_RS10175	COG2718	Belongs to the UPF0229 family
GPY27_RS10180	COG2719	SpoVR family
GPY27_RS10185	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY27_RS10195	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY27_RS10200	COG1132	(ABC) transporter
GPY27_RS10205	COG0658	competence protein
GPY27_RS10205	COG2333	competence protein COMEC
GPY27_RS10215	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY27_RS10220	COG1136	(ABC) transporter
GPY27_RS10225	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY27_RS10250	COG1252	NADH dehydrogenase
GPY27_RS10260	COG3150	esterase
GPY27_RS10285	COG0537	adenosine 5'-monophosphoramidase activity
GPY27_RS10315	COG0517	IMP dehydrogenase activity
GPY27_RS10315	COG0516	GMP reductase activity
GPY27_RS10325	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY27_RS10330	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY27_RS10335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY27_RS10345	COG2199	diguanylate cyclase activity
GPY27_RS10360	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY27_RS10365	COG1946	Acyl-CoA thioesterase
GPY27_RS10375	COG1522	sequence-specific DNA binding
GPY27_RS10405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY27_RS10410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY27_RS10455	COG0477	Major facilitator Superfamily
GPY27_RS10460	COG2855	membrane
GPY27_RS10475	COG1441	menaquinone biosynthetic process
GPY27_RS10480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY27_RS10485	COG0596	Alpha beta hydrolase
GPY27_RS10490	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY27_RS10495	COG1169	isochorismate synthase
GPY27_RS10500	COG0436	Aminotransferase
GPY27_RS10505	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY27_RS10510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY27_RS10525	COG1555	photosystem II stabilization
GPY27_RS10530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY27_RS10535	COG0776	regulation of translation
GPY27_RS10540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY27_RS10545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY27_RS10555	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY27_RS10565	COG2204	response regulator
GPY27_RS10580	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY27_RS10585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY27_RS10590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY27_RS10610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY27_RS10615	COG0569	domain protein
GPY27_RS10620	COG0513	Belongs to the DEAD box helicase family
GPY27_RS10625	COG1253	flavin adenine dinucleotide binding
GPY27_RS10660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY27_RS10665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY27_RS10680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY27_RS10685	COG1216	Glycosyl transferase, family 2
GPY27_RS10690	COG2986	histidine ammonia-lyase
GPY27_RS10715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY27_RS10720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY27_RS10725	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS10770	COG0732	type I restriction modification DNA specificity domain
GPY27_RS10780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY27_RS10785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY27_RS10815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY27_RS10820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY27_RS10825	COG0583	DNA-binding transcription factor activity
GPY27_RS10830	COG2951	lytic endotransglycosylase activity
GPY27_RS10835	COG3100	YcgL domain-containing protein
GPY27_RS10840	COG0850	regulation of cytokinetic process
GPY27_RS10845	COG2894	cell division
GPY27_RS10850	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY27_RS10855	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY27_RS10860	COG0318	PFAM AMP-dependent synthetase and ligase
GPY27_RS10865	COG2267	carboxylic ester hydrolase activity
GPY27_RS10880	COG1214	PFAM Peptidase M22, glycoprotease
GPY27_RS10885	COG1199	ATP-dependent helicase activity
GPY27_RS10890	COG0788	formyltetrahydrofolate deformylase activity
GPY27_RS10895	COG3102	Protein conserved in bacteria
GPY27_RS10905	COG0018	arginyl-trna synthetase
GPY27_RS10925	COG1918	ferrous iron import across plasma membrane
GPY27_RS10940	COG4977	sequence-specific DNA binding
GPY27_RS10945	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY27_RS10950	COG1121	(ABC) transporter
GPY27_RS10955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY27_RS10965	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY27_RS10970	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY27_RS10975	COG0567	Dehydrogenase, E1 component
GPY27_RS10980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY27_RS10985	COG1053	succinate dehydrogenase
GPY27_RS10990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY27_RS10995	COG2009	succinate dehydrogenase
GPY27_RS11005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY27_RS11015	COG0033	Phosphoglucomutase
GPY27_RS11020	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY27_RS11025	COG0596	Alpha beta hydrolase
GPY27_RS11035	COG0716	FMN binding
GPY27_RS11045	COG0735	belongs to the Fur family
GPY27_RS11050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY27_RS11055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY27_RS11055	COG1263	PTS System
GPY27_RS11055	COG2190	(PTS) system
GPY27_RS11065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY27_RS11070	COG1846	Transcriptional regulator
GPY27_RS11070	COG1940	carbohydrate kinase activity
GPY27_RS11075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY27_RS11075	COG4651	solute:proton antiporter activity
GPY27_RS11080	COG0367	asparagine synthase
GPY27_RS11085	COG0250	Participates in transcription elongation, termination and antitermination
GPY27_RS11090	COG3104	oligopeptide transport
GPY27_RS11095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY27_RS11100	COG0563	adenylate kinase activity
GPY27_RS11105	COG0326	Molecular chaperone. Has ATPase activity
GPY27_RS11110	COG3710	Transcriptional regulator
GPY27_RS11130	COG0622	Phosphoesterase
GPY27_RS11160	COG1090	epimerase
GPY27_RS11165	COG0300	oxidoreductase activity
GPY27_RS11175	COG3118	belongs to the thioredoxin family
GPY27_RS11180	COG0330	HflC and HflK could
GPY27_RS11205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY27_RS11210	COG3115	cell septum assembly
GPY27_RS11215	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY27_RS11220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY27_RS11230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY27_RS11235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY27_RS11240	COG2190	(PTS) system
GPY27_RS11250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY27_RS11255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY27_RS11265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY27_RS11275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY27_RS11285	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY27_RS11285	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY27_RS11290	COG1706	bacterial-type flagellum-dependent cell motility
GPY27_RS11295	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY27_RS11300	COG4786	Flagellar basal body rod
GPY27_RS11305	COG4787	bacterial-type flagellum-dependent cell motility
GPY27_RS11315	COG1749	Flagellar hook protein flgE
GPY27_RS11320	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY27_RS11325	COG1558	bacterial-type flagellum-dependent cell motility
GPY27_RS11330	COG1815	bacterial-type flagellum-dependent cell motility
GPY27_RS11335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY27_RS11340	COG0835	chemotaxis
GPY27_RS11340	COG0784	Response regulator, receiver
GPY27_RS11400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY27_RS11405	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY27_RS11420	COG2608	mercury ion transmembrane transporter activity
GPY27_RS11420	COG2217	Heavy metal translocating P-type atpase
GPY27_RS11460	COG2840	Smr protein MutS2
GPY27_RS11465	COG1187	pseudouridine synthase activity
GPY27_RS11475	COG0737	Belongs to the 5'-nucleotidase family
GPY27_RS11480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY27_RS11485	COG2912	Transglutaminase-like superfamily
GPY27_RS11490	COG3094	Invasion gene expression up-regulator, SirB
GPY27_RS11495	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY27_RS11500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY27_RS11505	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY27_RS11510	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY27_RS11515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY27_RS11520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY27_RS11525	COG0193	aminoacyl-tRNA hydrolase activity
GPY27_RS11530	COG0012	GTP binding
GPY27_RS11645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY27_RS11655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY27_RS11660	COG1702	phosphate starvation-inducible protein PhoH
GPY27_RS11665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY27_RS11670	COG4535	Mg2 and Co2 transporter CorC
GPY27_RS11675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY27_RS11680	COG2888	peptidyl-tyrosine sulfation
GPY27_RS11685	COG0495	leucyl-tRNA aminoacylation
GPY27_RS11690	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY27_RS11695	COG1466	dna polymerase III delta subunit
GPY27_RS11700	COG0799	negative regulation of ribosome biogenesis
GPY27_RS11705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY27_RS11710	COG0768	penicillin binding
GPY27_RS11715	COG0772	Belongs to the SEDS family
GPY27_RS11720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY27_RS11725	COG1686	Belongs to the peptidase S11 family
GPY27_RS11730	COG2921	Belongs to the UPF0250 family
GPY27_RS11735	COG0321	lipoyl(octanoyl) transferase activity
GPY27_RS11740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY27_RS11745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY27_RS11750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY27_RS11765	COG0366	Alpha amylase catalytic
GPY27_RS11770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY27_RS11770	COG1263	PTS System
GPY27_RS11780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY27_RS11790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY27_RS11795	COG2011	ABC-type metal ion transport system permease component
GPY27_RS11800	COG1464	Belongs to the NlpA lipoprotein family
GPY27_RS11805	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY27_RS11815	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY27_RS11815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY27_RS11825	COG0745	RESPONSE REGULATOR receiver
GPY27_RS11825	COG3706	GGDEF domain
GPY27_RS11830	COG1611	Belongs to the LOG family
GPY27_RS11835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY27_RS11845	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GPY27_RS11850	COG2363	Small membrane protein
GPY27_RS11860	COG0583	DNA-binding transcription factor activity
GPY27_RS11865	COG0301	tRNA thio-modification
GPY27_RS11865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY27_RS11870	COG2885	chlorophyll binding
GPY27_RS11875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY27_RS11880	COG1722	exodeoxyribonuclease VII activity
GPY27_RS11885	COG0142	geranyltranstransferase activity
GPY27_RS11890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY27_RS11895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY27_RS11900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY27_RS11905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY27_RS11925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY27_RS11925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY27_RS11930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY27_RS11935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY27_RS11940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY27_RS11955	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY27_RS11960	COG2252	PERMEase
GPY27_RS11965	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY27_RS11990	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY27_RS11990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY27_RS11995	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY27_RS12005	COG0590	tRNA wobble adenosine to inosine editing
GPY27_RS12010	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY27_RS12045	COG0484	heat shock protein binding
GPY27_RS12050	COG0443	Heat shock 70 kDa protein
GPY27_RS12060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY27_RS12065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY27_RS12075	COG0497	DNA recombination
GPY27_RS12080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY27_RS12085	COG2914	Belongs to the UPF0125 (RnfH) family
GPY27_RS12090	COG2867	negative regulation of translational initiation
GPY27_RS12095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY27_RS12115	COG0583	DNA-binding transcription factor activity
GPY27_RS12120	COG3153	acetyltransferase
GPY27_RS12120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY27_RS12140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY27_RS12145	COG2873	o-acetylhomoserine
GPY27_RS12180	COG1115	amino acid carrier protein
GPY27_RS12190	COG1584	GPR1 FUN34 yaaH family protein
GPY27_RS12200	COG1757	Na H antiporter
GPY27_RS12205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY27_RS12205	COG0519	Catalyzes the synthesis of GMP from XMP
GPY27_RS12210	COG0516	GMP reductase activity
GPY27_RS12210	COG0517	IMP dehydrogenase activity
GPY27_RS12215	COG1570	exodeoxyribonuclease VII activity
GPY27_RS12230	COG1160	GTP binding
GPY27_RS12235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY27_RS12240	COG2976	Protein conserved in bacteria
GPY27_RS12245	COG0124	histidyl-tRNA synthetase
GPY27_RS12250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY27_RS12265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY27_RS12270	COG0105	UTP biosynthetic process
GPY27_RS12275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY27_RS12280	COG2975	iron-sulfur cluster assembly
GPY27_RS12285	COG0633	Ferredoxin
GPY27_RS12290	COG0443	Heat shock 70 kDa protein
GPY27_RS12295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY27_RS12305	COG0822	iron-sulfur transferase activity
GPY27_RS12310	COG1104	cysteine desulfurase activity
GPY27_RS12325	COG0483	inositol monophosphate 1-phosphatase activity
GPY27_RS12330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY27_RS12335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY27_RS12340	COG1862	Preprotein translocase
GPY27_RS12345	COG0343	queuine tRNA-ribosyltransferase activity
GPY27_RS12350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY27_RS12360	COG0517	IMP dehydrogenase activity
GPY27_RS12370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY27_RS12380	COG0583	DNA-binding transcription factor activity
GPY27_RS12385	COG0450	alkyl hydroperoxide reductase
GPY27_RS12390	COG3142	Participates in the control of copper homeostasis
GPY27_RS12400	COG0704	Plays a role in the regulation of phosphate uptake
GPY27_RS12405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY27_RS12410	COG0581	inorganic phosphate transmembrane transporter activity
GPY27_RS12420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY27_RS12425	COG0248	Ppx GppA phosphatase
GPY27_RS12435	COG5002	protein histidine kinase activity
GPY27_RS12440	COG0745	RESPONSE REGULATOR receiver
GPY27_RS12445	COG2974	May be involved in recombination
GPY27_RS12455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY27_RS12515	COG0542	response to heat
GPY27_RS12525	COG0564	pseudouridine synthase activity
GPY27_RS12530	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY27_RS12535	COG0741	lytic transglycosylase activity
GPY27_RS12535	COG1196	nuclear chromosome segregation
GPY27_RS12535	COG0739	heme binding
GPY27_RS12540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY27_RS12545	COG0077	Prephenate dehydratase
GPY27_RS12545	COG1605	Chorismate mutase
GPY27_RS12550	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY27_RS12555	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY27_RS12565	COG0488	(ABC) transporter
GPY27_RS12580	COG0739	heme binding
GPY27_RS12585	COG0287	Prephenate dehydrogenase
GPY27_RS12585	COG1605	Chorismate mutase
GPY27_RS12590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY27_RS12595	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY27_RS12600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY27_RS12605	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY27_RS12620	COG1966	Carbon starvation protein
GPY27_RS12625	COG3275	phosphorelay sensor kinase activity
GPY27_RS12630	COG3279	Response regulator of the LytR AlgR family
GPY27_RS12635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY27_RS12640	COG1047	Peptidyl-prolyl cis-trans
GPY27_RS12645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY27_RS12650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY27_RS12655	COG0196	riboflavin kinase activity
GPY27_RS12660	COG0728	peptidoglycan biosynthetic process
GPY27_RS12665	COG0268	Binds directly to 16S ribosomal RNA
GPY27_RS12675	COG0640	Transcriptional regulator
GPY27_RS12685	COG0583	DNA-binding transcription factor activity
GPY27_RS12690	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY27_RS12700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY27_RS12705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY27_RS12710	COG0730	response to heat
GPY27_RS12720	COG0494	nUDIX hydrolase
GPY27_RS12730	COG3066	DNA modification
GPY27_RS12740	COG0667	Aldo Keto reductase
GPY27_RS12750	COG2204	response regulator
GPY27_RS12755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY27_RS12765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY27_RS12770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY27_RS12780	COG0716	FMN binding
GPY27_RS12790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY27_RS12795	COG0513	Belongs to the DEAD box helicase family
GPY27_RS12800	COG3022	response to hydroperoxide
GPY27_RS12805	COG1115	amino acid carrier protein
GPY27_RS12820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY27_RS12830	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY27_RS12835	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY27_RS12840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY27_RS12845	COG0083	homoserine kinase activity
GPY27_RS12860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY27_RS12875	COG0745	RESPONSE REGULATOR receiver
GPY27_RS12885	COG0784	Response regulator, receiver
GPY27_RS12885	COG2198	Histidine kinase
GPY27_RS12885	COG5002	protein histidine kinase activity
GPY27_RS12890	COG5001	Diguanylate cyclase
GPY27_RS12890	COG4251	negative regulation of phosphorylation
GPY27_RS12890	COG2203	Gaf domain
GPY27_RS12890	COG3706	GGDEF domain
GPY27_RS12895	COG1242	4 iron, 4 sulfur cluster binding
GPY27_RS12900	COG0069	glutamate synthase activity
GPY27_RS12900	COG0067	glutamate synthase
GPY27_RS12900	COG0070	glutamate synthase
GPY27_RS12910	COG0067	glutamate synthase
GPY27_RS12910	COG0070	glutamate synthase
GPY27_RS12910	COG0069	glutamate synthase activity
GPY27_RS12915	COG0493	'glutamate synthase
GPY27_RS12925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY27_RS12935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY27_RS12940	COG2860	membrane
GPY27_RS12945	COG0583	DNA-binding transcription factor activity
GPY27_RS12950	COG0730	response to heat
GPY27_RS12965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY27_RS12970	COG0505	Belongs to the CarA family
GPY27_RS12975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY27_RS12980	COG0494	nUDIX hydrolase
GPY27_RS12985	COG0653	protein targeting
GPY27_RS12995	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY27_RS13000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY27_RS13005	COG0849	cell division
GPY27_RS13010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY27_RS13015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY27_RS13020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY27_RS13025	COG0772	Belongs to the SEDS family
GPY27_RS13030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY27_RS13035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY27_RS13040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY27_RS13045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY27_RS13050	COG0768	penicillin binding
GPY27_RS13055	COG3116	cell division
GPY27_RS13060	COG0275	rRNA processing
GPY27_RS13075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY27_RS13085	COG0792	nuclease activity
GPY27_RS13090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY27_RS13095	COG2823	Periplasmic or secreted lipoprotein
GPY27_RS13100	COG2969	positive regulation of protein catabolic process
GPY27_RS13105	COG0625	glutathione transferase activity
GPY27_RS13110	COG2857	Cytochrome c1
GPY27_RS13115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY27_RS13120	COG0723	plastoquinol--plastocyanin reductase activity
GPY27_RS13125	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY27_RS13130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY27_RS13140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY27_RS13150	COG3105	Protein conserved in bacteria
GPY27_RS13160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY27_RS13170	COG0187	DNA topoisomerase II activity
GPY27_RS13175	COG3150	esterase
GPY27_RS13185	COG3151	Protein conserved in bacteria
GPY27_RS13190	COG0494	nUDIX hydrolase
GPY27_RS13195	COG1538	Outer membrane efflux protein
GPY27_RS13200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY27_RS13200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY27_RS13205	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY27_RS13220	COG3025	triphosphatase activity
GPY27_RS13225	COG1392	Phosphate transport regulator
GPY27_RS13230	COG0306	phosphate transporter
GPY27_RS13235	COG4991	sh3 domain protein
GPY27_RS13245	COG3409	Peptidoglycan-binding domain 1 protein
GPY27_RS13245	COG3267	Type II secretory pathway component ExeA
GPY27_RS13250	COG0617	tRNA 3'-terminal CCA addition
GPY27_RS13255	COG1968	undecaprenyl-diphosphatase activity
GPY27_RS13260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY27_RS13265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY27_RS13270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY27_RS13275	COG0596	Alpha beta hydrolase
GPY27_RS13280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY27_RS13285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY27_RS13290	COG1610	YqeY-like protein
GPY27_RS13295	COG0358	DNA primase activity
GPY27_RS13300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY27_RS13360	COG0582	viral genome integration into host DNA
GPY27_RS13365	COG1464	Belongs to the NlpA lipoprotein family
GPY27_RS13400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY27_RS13400	COG2213	PTS system mannitol-specific
GPY27_RS13405	COG0246	Mannitol dehydrogenase
GPY27_RS13410	COG3722	fumarate hydratase activity
GPY27_RS13415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY27_RS13420	COG5002	protein histidine kinase activity
GPY27_RS13435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY27_RS13440	COG1349	DNA-binding transcription factor activity
GPY27_RS13450	COG0469	pyruvate kinase activity
GPY27_RS13460	COG3706	GGDEF domain
GPY27_RS13465	COG0440	acetolactate synthase activity
GPY27_RS13470	COG0028	Belongs to the TPP enzyme family
GPY27_RS13475	COG1022	Amp-dependent synthetase and ligase
GPY27_RS13480	COG0583	DNA-binding transcription factor activity
GPY27_RS13500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY27_RS13505	COG0473	3-isopropylmalate dehydrogenase activity
GPY27_RS13510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY27_RS13515	COG0066	3-isopropylmalate dehydratase activity
GPY27_RS13525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY27_RS13530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY27_RS13535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY27_RS13540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY27_RS13545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY27_RS13550	COG2967	ApaG domain
GPY27_RS13555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY27_RS13570	COG2966	Psort location CytoplasmicMembrane, score
GPY27_RS13575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY27_RS13585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY27_RS13590	COG0142	geranyltranstransferase activity
GPY27_RS13600	COG0039	L-malate dehydrogenase activity
GPY27_RS13635	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY27_RS13640	COG1178	ABC-type Fe3 transport system permease component
GPY27_RS13645	COG4143	(ABC) transporter
GPY27_RS13650	COG0163	prenyltransferase activity
GPY27_RS13655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY27_RS13665	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY27_RS13670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY27_RS13680	COG2105	PFAM AIG2 family protein
GPY27_RS13685	COG2911	Protein conserved in bacteria
GPY27_RS13690	COG0729	surface antigen
GPY27_RS13695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY27_RS13705	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY27_RS13720	COG4181	ATPase activity
GPY27_RS13740	COG0529	Catalyzes the synthesis of activated sulfate
GPY27_RS13745	COG3273	potassium ion transport
GPY27_RS13745	COG0471	metal ion transport
GPY27_RS13755	COG2895	sulfate adenylyltransferase (ATP) activity
GPY27_RS13760	COG0175	sulfate reduction
GPY27_RS13765	COG1648	precorrin-2 dehydrogenase activity
GPY27_RS13765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY27_RS13770	COG0737	Belongs to the 5'-nucleotidase family
GPY27_RS13780	COG0513	Belongs to the DEAD box helicase family
GPY27_RS13785	COG2153	protein acetylation
GPY27_RS13795	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY27_RS13805	COG0203	ribosomal protein L17
GPY27_RS13810	COG0202	RNA polymerase activity
GPY27_RS13820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY27_RS13825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY27_RS13835	COG0201	protein transport
GPY27_RS13840	COG0200	Binds to the 23S rRNA
GPY27_RS13845	COG1841	ribosomal large subunit assembly
GPY27_RS13860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY27_RS13865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY27_RS13870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY27_RS13875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY27_RS13880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY27_RS13885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY27_RS13890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY27_RS13895	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY27_RS13905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY27_RS13910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY27_RS13915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY27_RS13920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY27_RS13930	COG0088	Forms part of the polypeptide exit tunnel
GPY27_RS13935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY27_RS13945	COG0254	rRNA binding
GPY27_RS13955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY27_RS13960	COG1609	Transcriptional regulator
GPY27_RS13970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY27_RS13975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY27_RS13980	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY27_RS13985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY27_RS13990	COG3074	FtsZ-dependent cytokinesis
GPY27_RS14000	COG1494	fructose-1,6-bisphosphatase
GPY27_RS14025	COG0149	triose-phosphate isomerase activity
GPY27_RS14050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY27_RS14080	COG2244	polysaccharide biosynthetic process
GPY27_RS14105	COG2089	acid synthase
GPY27_RS14110	COG1083	cytidylyl-transferase
GPY27_RS14145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY27_RS14155	COG1560	Kdo2-lipid A biosynthetic process
GPY27_RS14160	COG0859	PFAM glycosyl transferase family 9
GPY27_RS14165	COG1519	Transferase
GPY27_RS14190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY27_RS14195	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS14205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY27_RS14235	COG3642	lipopolysaccharide core region biosynthetic process
GPY27_RS14240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY27_RS14245	COG0859	PFAM glycosyl transferase family 9
GPY27_RS14250	COG0463	Glycosyl transferase, family 2
GPY27_RS14265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY27_RS14270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY27_RS14285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY27_RS14290	COG2003	Belongs to the UPF0758 family
GPY27_RS14305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY27_RS14310	COG1309	transcriptional regulator
GPY27_RS14315	COG1560	Kdo2-lipid A biosynthetic process
GPY27_RS14320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY27_RS14325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY27_RS14330	COG1561	YicC-like family, N-terminal region
GPY27_RS14340	COG4608	Belongs to the ABC transporter superfamily
GPY27_RS14345	COG0444	Belongs to the ABC transporter superfamily
GPY27_RS14350	COG0747	negative chemotaxis
GPY27_RS14355	COG4239	(ABC) transporter, permease
GPY27_RS14360	COG4174	ABC transporter (Permease)
GPY27_RS14385	COG0811	peptide transport
GPY27_RS14390	COG0848	biopolymer transport protein
GPY27_RS14405	COG0194	GDP metabolic process
GPY27_RS14410	COG1758	RNA polymerase activity
GPY27_RS14415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY27_RS14420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY27_RS14425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY27_RS14430	COG2233	PERMEase
GPY27_RS14435	COG2205	protein histidine kinase activity
GPY27_RS14440	COG0745	RESPONSE REGULATOR receiver
GPY27_RS14450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY27_RS14460	COG2183	response to ionizing radiation
GPY27_RS14470	COG0596	Alpha beta hydrolase
GPY27_RS14475	COG1040	competence protein
GPY27_RS14480	COG0316	Belongs to the HesB IscA family
GPY27_RS14480	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY27_RS14485	COG0494	nUDIX hydrolase
GPY27_RS14490	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY27_RS14500	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY27_RS14505	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY27_RS14510	COG3156	type II secretion system protein K
GPY27_RS14515	COG4795	General secretion pathway protein
GPY27_RS14520	COG2165	general secretion pathway protein
GPY27_RS14525	COG2165	general secretion pathway protein
GPY27_RS14530	COG2165	general secretion pathway protein
GPY27_RS14535	COG1459	type II secretion system
GPY27_RS14540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY27_RS14550	COG3031	protein transport across the cell outer membrane
GPY27_RS14555	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY27_RS14560	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY27_RS14565	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY27_RS14575	COG0456	acetyltransferase
GPY27_RS14580	COG1490	D-aminoacyl-tRNA deacylase activity
GPY27_RS14585	COG1295	ribonuclease BN
GPY27_RS14605	COG0174	glutamine synthetase
GPY27_RS14615	COG3852	Histidine kinase
GPY27_RS14620	COG2204	response regulator
GPY27_RS14630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY27_RS14635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY27_RS14670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY27_RS14680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY27_RS14680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY27_RS14705	COG0084	hydrolase, TatD family'
GPY27_RS14715	COG0805	protein transport
GPY27_RS14730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY27_RS14735	COG3165	ubiquinone biosynthetic process from chorismate
GPY27_RS14740	COG2226	methyltransferase
GPY27_RS14745	COG1322	Protein conserved in bacteria
GPY27_RS14760	COG0628	permease
GPY27_RS14810	COG2823	Periplasmic or secreted lipoprotein
GPY27_RS14820	COG2081	HI0933 family
GPY27_RS14830	COG1528	Iron-storage protein
GPY27_RS14835	COG0589	response to stress
GPY27_RS14840	COG0697	spore germination
GPY27_RS14850	COG0742	ribosomal rna small subunit methyltransferase
GPY27_RS14855	COG5002	protein histidine kinase activity
GPY27_RS14855	COG5001	Diguanylate cyclase
GPY27_RS14860	COG1522	sequence-specific DNA binding
GPY27_RS14865	COG0339	signal peptide processing
GPY27_RS14870	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY27_RS14875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY27_RS14880	COG0583	DNA-binding transcription factor activity
GPY27_RS14885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY27_RS14890	COG0800	Aldolase
GPY27_RS14895	COG2610	gluconate transmembrane transporter activity
GPY27_RS14900	COG3265	gluconokinase activity
GPY27_RS14905	COG0129	dihydroxy-acid dehydratase activity
GPY27_RS14910	COG2076	Multidrug Resistance protein
GPY27_RS14920	COG0583	DNA-binding transcription factor activity
GPY27_RS14925	COG1609	Transcriptional regulator
GPY27_RS14965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY27_RS14975	COG0747	negative chemotaxis
GPY27_RS14980	COG4172	Belongs to the ABC transporter superfamily
GPY27_RS15045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY27_RS15050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY27_RS15060	COG2960	long-chain fatty acid transporting porin activity
GPY27_RS15065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY27_RS15070	COG0583	DNA-binding transcription factor activity
GPY27_RS15110	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY27_RS15120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY27_RS15125	COG0408	coproporphyrinogen oxidase activity
GPY27_RS15130	COG0009	L-threonylcarbamoyladenylate synthase
GPY27_RS15135	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY27_RS15140	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY27_RS15145	COG0551	DNA topoisomerase type I activity
GPY27_RS15150	COG2922	Belongs to the Smg family
GPY27_RS15155	COG0758	DNA mediated transformation
GPY27_RS15165	COG0242	peptide deformylase activity
GPY27_RS15170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY27_RS15175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY27_RS15175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY27_RS15180	COG0569	domain protein
GPY27_RS15185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY27_RS15195	COG1272	protein, Hemolysin III
GPY27_RS15200	COG4326	sporulation control protein
GPY27_RS15210	COG3084	Protein conserved in bacteria
GPY27_RS15220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY27_RS15225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY27_RS15230	COG0204	Acyl-transferase
GPY27_RS15240	COG0606	chelatase, subunit chli
GPY27_RS15250	COG3978	acetolactate synthase activity
GPY27_RS15255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY27_RS15260	COG0129	dihydroxy-acid dehydratase activity
GPY27_RS15270	COG0583	DNA-binding transcription factor activity
GPY27_RS15275	COG2814	Major facilitator Superfamily
GPY27_RS15280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY27_RS15285	COG0765	amino acid transport
GPY27_RS15290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY27_RS15295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY27_RS15300	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY27_RS15305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY27_RS15310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY27_RS15315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY27_RS15330	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY27_RS15335	COG3312	ion transport
GPY27_RS15340	COG1475	DNA binding
GPY27_RS15345	COG1192	Involved in chromosome partitioning
GPY27_RS15350	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY27_RS15355	COG0445	tRNA wobble uridine modification
GPY27_RS15360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY27_RS15365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY27_RS15370	COG0706	membrane insertase activity
GPY27_RS15375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY27_RS15380	COG0594	ribonuclease P activity
GPY27_RS15390	COG1126	abc transporter atp-binding protein
GPY27_RS15415	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY27_RS15420	COG0592	DNA-directed DNA polymerase activity
GPY27_RS15425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY27_RS15430	COG0187	DNA topoisomerase II activity
GPY27_RS15450	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY27_RS15455	COG3977	Valine--pyruvate aminotransferase
GPY27_RS15460	COG0366	Alpha amylase catalytic
GPY27_RS15465	COG0751	glycine-tRNA ligase activity
GPY27_RS15470	COG0752	glycyl-tRNA synthetase alpha subunit
GPY27_RS15475	COG2119	membrane
GPY27_RS15485	COG0425	Belongs to the sulfur carrier protein TusA family
GPY27_RS15500	COG0604	alcohol dehydrogenase
GPY27_RS15505	COG0183	Belongs to the thiolase family
GPY27_RS15510	COG1024	Enoyl-CoA hydratase
GPY27_RS15510	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY27_RS15515	COG1739	Uncharacterized protein family UPF0029
GPY27_RS15520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY27_RS15575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY27_RS15580	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY27_RS15585	COG0352	thiamine-phosphate diphosphorylase activity
GPY27_RS15590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY27_RS15595	COG2104	thiamine diphosphate biosynthetic process
GPY27_RS15600	COG2022	thiamine diphosphate biosynthetic process
GPY27_RS15610	COG0006	proline dipeptidase activity
GPY27_RS15610	COG0006	proline dipeptidase activity
GPY27_RS15640	COG3220	belongs to the UPF0276 family
GPY27_RS15650	COG0210	DNA helicase
GPY27_RS15660	COG0405	Gamma-glutamyltransferase
GPY27_RS15665	COG1280	lysine exporter protein (LysE YggA)
GPY27_RS15675	COG2962	Rard protein
GPY27_RS15680	COG0514	ATP-dependent DNA helicase (RecQ)
GPY27_RS15695	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY27_RS15700	COG0248	Ppx GppA phosphatase
GPY27_RS15705	COG0513	Belongs to the DEAD box helicase family
GPY27_RS15710	COG3118	belongs to the thioredoxin family
GPY27_RS15715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY27_RS15730	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY27_RS15735	COG0633	Ferredoxin
GPY27_RS15785	COG3071	HemY protein
GPY27_RS15790	COG2959	enzyme of heme biosynthesis
GPY27_RS15795	COG1587	Uroporphyrinogen-III synthase
GPY27_RS15800	COG0181	hydroxymethylbilane synthase activity
GPY27_RS15805	COG3072	Adenylate cyclase
GPY27_RS15810	COG1965	Belongs to the frataxin family
GPY27_RS15820	COG0019	diaminopimelate decarboxylase activity
GPY27_RS15825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY27_RS15835	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY27_RS15840	COG1011	Hydrolase
GPY27_RS15845	COG3287	FIST C domain
GPY27_RS15845	COG2200	EAL domain
GPY27_RS15845	COG2199	diguanylate cyclase activity
GPY27_RS15865	COG0561	phosphatase activity
GPY27_RS15870	COG2267	carboxylic ester hydrolase activity
GPY27_RS15875	COG1280	lysine exporter protein (LysE YggA)
GPY27_RS15880	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY27_RS15885	COG0640	Transcriptional regulator
GPY27_RS15890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY27_RS15945	COG2095	MarC family integral membrane protein
GPY27_RS15955	COG0742	ribosomal rna small subunit methyltransferase
GPY27_RS15960	COG0552	protein localization to endoplasmic reticulum
GPY27_RS15965	COG2884	Cell division ATP-binding protein ftsE
GPY27_RS15970	COG2177	Part of the ABC transporter FtsEX involved in
GPY27_RS15980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY27_RS15985	COG0705	Rhomboid family
GPY27_RS15990	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY27_RS15995	COG3161	chorismate lyase activity
GPY27_RS16000	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY27_RS16005	COG2937	Belongs to the GPAT DAPAT family
GPY27_RS16015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY27_RS16020	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY27_RS16025	COG0534	Mate efflux family protein
GPY27_RS16030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY27_RS16045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY27_RS16050	COG4206	TonB-dependent receptor
GPY27_RS16060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY27_RS16125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY27_RS16135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY27_RS16170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY27_RS16180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY27_RS16185	COG0250	Participates in transcription elongation, termination and antitermination
GPY27_RS16190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY27_RS16195	COG0081	regulation of translation
GPY27_RS16200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY27_RS16205	COG0222	ribosome binding
GPY27_RS16210	COG0085	RNA polymerase activity
GPY27_RS16215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY27_RS16220	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY27_RS16225	COG2816	NAD+ diphosphatase activity
GPY27_RS16240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY27_RS16245	COG1573	uracil-dna glycosylase
GPY27_RS16250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY27_RS16255	COG3068	Protein conserved in bacteria
GPY27_RS16260	COG1253	flavin adenine dinucleotide binding
GPY27_RS16275	COG0151	Belongs to the GarS family
GPY27_RS16285	COG0138	bifunctional purine biosynthesis protein purh
GPY27_RS16295	COG0789	Transcriptional regulator
GPY27_RS16300	COG3710	Transcriptional regulator
GPY27_RS16310	COG0531	amino acid
GPY27_RS16315	COG1982	Orn Lys Arg decarboxylase major
GPY27_RS16335	COG0109	protoheme IX farnesyltransferase activity
GPY27_RS16340	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY27_RS16375	COG1278	Cold shock
GPY27_RS16380	COG3036	rescue of stalled ribosome
GPY27_RS16395	COG2199	diguanylate cyclase activity
GPY27_RS16415	COG0577	efflux transmembrane transporter activity
GPY27_RS16415	COG1136	(ABC) transporter
GPY27_RS16425	COG0840	transmembrane signaling receptor activity
GPY27_RS16430	COG0783	Belongs to the Dps family
GPY27_RS16440	COG2133	pyrroloquinoline quinone binding
GPY27_RS16445	COG1454	alcohol dehydrogenase
GPY27_RS16450	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY27_RS16490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY27_RS16495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY27_RS16500	COG3186	Phenylalanine-4-hydroxylase
GPY27_RS16505	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY27_RS16530	COG3530	Putative quorum-sensing-regulated virulence factor
GPY27_RS16535	COG0513	Belongs to the DEAD box helicase family
GPY27_RS16540	COG4628	conserved protein (DUF2132)
GPY27_RS16545	COG0133	tryptophan synthase activity
GPY27_RS16555	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY27_RS16565	COG0523	cobalamin synthesis protein
GPY27_RS16570	COG0513	Belongs to the DEAD box helicase family
GPY27_RS16590	COG2200	EAL domain
GPY27_RS16595	COG1119	ATPase activity
GPY27_RS16600	COG0840	transmembrane signaling receptor activity
GPY27_RS16625	COG0641	radical SAM
GPY27_RS16645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY27_RS16660	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY27_RS16665	COG0513	Belongs to the DEAD box helicase family
GPY27_RS16670	COG5001	Diguanylate cyclase
GPY27_RS16680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY27_RS16695	COG5413	integral membrane protein
GPY27_RS16705	COG1024	Enoyl-CoA hydratase
GPY27_RS16710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY27_RS16715	COG1960	acyl-CoA dehydrogenase activity
GPY27_RS16725	COG0183	Belongs to the thiolase family
GPY27_RS16745	COG1024	Enoyl-CoA hydratase
GPY27_RS16755	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS16760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY27_RS16765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY27_RS16770	COG1845	cytochrome c oxidase, subunit III
GPY27_RS16775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY27_RS16780	COG0109	protoheme IX farnesyltransferase activity
GPY27_RS16795	COG1902	pentaerythritol trinitrate reductase activity
GPY27_RS16825	COG1126	abc transporter atp-binding protein
GPY27_RS16830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY27_RS16835	COG4215	(ABC) transporter
GPY27_RS16840	COG4160	amino acid transport
GPY27_RS16855	COG0625	glutathione transferase activity
GPY27_RS16890	COG0443	Heat shock 70 kDa protein
GPY27_RS16895	COG2847	Copper chaperone PCu(A)C
GPY27_RS16920	COG4607	ABC-type enterochelin transport system periplasmic component
GPY27_RS16925	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY27_RS16930	COG4605	iron ion homeostasis
GPY27_RS16935	COG4604	ABC transporter, ATP-binding protein
GPY27_RS16940	COG0789	Transcriptional regulator
GPY27_RS16955	COG1629	transport
GPY27_RS16955	COG4771	TonB-dependent receptor
GPY27_RS16990	COG1289	transmembrane transporter activity
GPY27_RS16995	COG0210	DNA helicase
GPY27_RS17000	COG1803	Methylglyoxal synthase
GPY27_RS17005	COG1879	ABC-type sugar transport system periplasmic component
GPY27_RS17010	COG2205	protein histidine kinase activity
GPY27_RS17010	COG0784	Response regulator, receiver
GPY27_RS17010	COG2198	Histidine kinase
GPY27_RS17025	COG0745	RESPONSE REGULATOR receiver
GPY27_RS17030	COG3119	arylsulfatase activity
GPY27_RS17035	COG3119	arylsulfatase activity
GPY27_RS17050	COG3119	arylsulfatase activity
GPY27_RS17055	COG0641	radical SAM
GPY27_RS17060	COG0714	Associated with various cellular activities
GPY27_RS17090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY27_RS17095	COG0583	DNA-binding transcription factor activity
GPY27_RS17100	COG1597	lipid kinase activity
GPY27_RS17105	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY27_RS17125	COG0641	radical SAM
GPY27_RS17155	COG0501	Belongs to the peptidase M48B family
GPY27_RS17160	COG1704	LemA family
GPY27_RS17165	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY27_RS17175	COG1214	PFAM Peptidase M22, glycoprotease
GPY27_RS17175	COG0456	acetyltransferase
GPY27_RS17195	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY27_RS17215	COG2207	Transcriptional regulator
GPY27_RS17240	COG4964	Belongs to the GSP D family
GPY27_RS17300	COG0583	DNA-binding transcription factor activity
GPY27_RS17305	COG0583	DNA-binding transcription factor activity
GPY27_RS17320	COG5001	Diguanylate cyclase
GPY27_RS17320	COG3300	MHYT domain
GPY27_RS17325	COG2197	response regulator
GPY27_RS17330	COG3706	GGDEF domain
GPY27_RS17340	COG2197	response regulator
GPY27_RS17365	COG0784	Response regulator, receiver
GPY27_RS17365	COG0835	chemotaxis
GPY27_RS17385	COG2962	Rard protein
GPY27_RS17400	COG0671	phosphoesterase, PA-phosphatase related
GPY27_RS17415	COG2076	Multidrug Resistance protein
GPY27_RS17445	COG0471	metal ion transport
GPY27_RS17450	COG3290	protein histidine kinase activity
GPY27_RS17455	COG4565	transcriptional regulatory protein
GPY27_RS17465	COG0069	glutamate synthase activity
GPY27_RS17465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY27_RS17475	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY27_RS17500	COG1902	pentaerythritol trinitrate reductase activity
GPY27_RS17505	COG0346	lactoylglutathione lyase activity
GPY27_RS17525	COG2239	Acts as a magnesium transporter
GPY27_RS17555	COG0242	peptide deformylase activity
GPY27_RS17600	COG2176	DNA-directed DNA polymerase activity
GPY27_RS17605	COG0583	DNA-binding transcription factor activity
GPY27_RS17610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY27_RS17615	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY27_RS17670	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY27_RS17680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY27_RS17680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY27_RS17685	COG0509	glycine decarboxylation via glycine cleavage system
GPY27_RS17690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY27_RS17730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY27_RS17730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY27_RS17730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY27_RS17735	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY27_RS17740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY27_RS17740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY27_RS17745	COG1609	Transcriptional regulator
GPY27_RS17765	COG2203	Gaf domain
GPY27_RS17765	COG2199	diguanylate cyclase activity
GPY27_RS17765	COG2200	EAL domain
GPY27_RS17770	COG0765	amino acid transport
GPY27_RS17775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY27_RS17780	COG0765	amino acid transport
GPY27_RS17785	COG1126	abc transporter atp-binding protein
GPY27_RS17790	COG0469	pyruvate kinase activity
GPY27_RS17795	COG2271	Major facilitator Superfamily
GPY27_RS17800	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY27_RS17820	COG1979	alcohol dehydrogenase
GPY27_RS17825	COG2207	Transcriptional regulator
GPY27_RS17840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY27_RS17845	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY27_RS17850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY27_RS17870	COG0784	Response regulator, receiver
GPY27_RS17870	COG3437	response regulator, receiver
GPY27_RS17880	COG0546	phosphoglycolate phosphatase activity
GPY27_RS17885	COG0840	transmembrane signaling receptor activity
GPY27_RS17895	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY27_RS17900	COG0513	Belongs to the DEAD box helicase family
GPY27_RS17905	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY27_RS17920	COG3038	cytochrome b561
GPY27_RS17925	COG2353	YceI-like domain
GPY27_RS17930	COG2116	formate transmembrane transporter activity
GPY27_RS17935	COG0583	DNA-binding transcription factor activity
GPY27_RS17945	COG3593	DNA synthesis involved in DNA repair
GPY27_RS17950	COG0737	Belongs to the 5'-nucleotidase family
GPY27_RS17955	COG0861	Integral membrane protein TerC family
GPY27_RS17970	COG2267	carboxylic ester hydrolase activity
GPY27_RS17975	COG2067	long-chain fatty acid transport protein
GPY27_RS17990	COG2050	protein possibly involved in aromatic compounds catabolism
GPY27_RS18000	COG4533	DNA binding
GPY27_RS18025	COG0484	heat shock protein binding
GPY27_RS18035	COG5001	Diguanylate cyclase
GPY27_RS18035	COG3300	MHYT domain
GPY27_RS18040	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY27_RS18050	COG4181	ATPase activity
GPY27_RS18055	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY27_RS18065	COG1984	allophanate hydrolase subunit 2
GPY27_RS18070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY27_RS18075	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY27_RS18080	COG5002	protein histidine kinase activity
GPY27_RS18080	COG3447	MASE1 domain protein
GPY27_RS18080	COG5001	Diguanylate cyclase
GPY27_RS18085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY27_RS18095	COG1629	transport
GPY27_RS18095	COG4771	TonB-dependent receptor
GPY27_RS18100	COG0583	DNA-binding transcription factor activity
GPY27_RS18105	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY27_RS18105	COG1042	CoA-binding domain protein
GPY27_RS18105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY27_RS18115	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY27_RS18125	COG0023	Translation Initiation Factor
GPY27_RS18205	COG0583	DNA-binding transcription factor activity
GPY27_RS18215	COG0589	response to stress
GPY27_RS18220	COG3140	Belongs to the UPF0181 family
GPY27_RS18245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY27_RS18250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY27_RS18265	COG0745	RESPONSE REGULATOR receiver
GPY27_RS18265	COG3706	GGDEF domain
GPY27_RS18275	COG3706	GGDEF domain
GPY27_RS18275	COG4251	negative regulation of phosphorylation
GPY27_RS18275	COG2203	Gaf domain
GPY27_RS18275	COG5001	Diguanylate cyclase
GPY27_RS18285	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY27_RS18290	COG4149	molybdate abc transporter
GPY27_RS18295	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY27_RS18300	COG1492	cobalamin metabolic process
GPY27_RS18305	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY27_RS18315	COG0189	ligase activity
GPY27_RS18315	COG4067	protein conserved in archaea
GPY27_RS18335	COG0534	Mate efflux family protein
GPY27_RS18340	COG0602	queuosine metabolic process
GPY27_RS18345	COG1328	CTP reductase activity
GPY27_RS18360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY27_RS18390	COG0243	molybdopterin cofactor binding
GPY27_RS18400	COG0583	DNA-binding transcription factor activity
GPY27_RS18405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY27_RS18415	COG2197	response regulator
GPY27_RS18420	COG3851	Histidine kinase
GPY27_RS18425	COG2271	Major facilitator Superfamily
GPY27_RS18455	COG3118	belongs to the thioredoxin family
GPY27_RS18460	COG2814	Major facilitator Superfamily
GPY27_RS18470	COG0534	Mate efflux family protein
GPY27_RS18500	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY27_RS18525	COG2146	nitrite reductase [NAD(P)H] activity
GPY27_RS18530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY27_RS18535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY27_RS18575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY27_RS18575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY27_RS18620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY27_RS18640	COG0277	FAD linked oxidase domain protein
GPY27_RS18645	COG0583	DNA-binding transcription factor activity
GPY27_RS18665	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY27_RS18680	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY27_RS18695	COG1288	antiporter activity
GPY27_RS18705	COG2814	Major facilitator Superfamily
GPY27_RS18715	COG3040	lipid binding
GPY27_RS18755	COG3501	Rhs element vgr protein
GPY27_RS18810	COG0631	protein serine/threonine phosphatase activity
GPY27_RS18845	COG0515	serine threonine protein kinase
GPY27_RS18845	COG2815	serine threonine protein kinase
GPY27_RS18900	COG2146	nitrite reductase [NAD(P)H] activity
GPY27_RS18900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY27_RS18905	COG1116	anion transmembrane transporter activity
GPY27_RS18910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY27_RS18915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY27_RS18925	COG3707	response regulator
GPY27_RS18945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY27_RS18945	COG1648	precorrin-2 dehydrogenase activity
GPY27_RS18950	COG0243	molybdopterin cofactor binding
GPY27_RS18955	COG0456	acetyltransferase
GPY27_RS18960	COG0814	amino acid
GPY27_RS18970	COG3706	GGDEF domain
GPY27_RS18970	COG0745	RESPONSE REGULATOR receiver
GPY27_RS18990	COG1785	Belongs to the alkaline phosphatase family
GPY27_RS19005	COG0745	RESPONSE REGULATOR receiver
GPY27_RS19025	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY27_RS19040	COG1609	Transcriptional regulator
GPY27_RS19045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY27_RS19050	COG1879	ABC-type sugar transport system periplasmic component
GPY27_RS19055	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY27_RS19060	COG1129	ABC transporter
GPY27_RS19065	COG1869	D-ribose catabolic process
GPY27_RS19070	COG5001	Diguanylate cyclase
GPY27_RS19075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY27_RS19135	COG2205	protein histidine kinase activity
GPY27_RS19135	COG0784	Response regulator, receiver
GPY27_RS19155	COG3300	MHYT domain
GPY27_RS19155	COG5001	Diguanylate cyclase
GPY27_RS19165	COG0330	HflC and HflK could
GPY27_RS19180	COG0517	IMP dehydrogenase activity
GPY27_RS19180	COG4175	Glycine betaine
GPY27_RS19185	COG4176	ABC-type proline glycine betaine transport system permease component
GPY27_RS19200	COG1012	belongs to the aldehyde dehydrogenase family
GPY27_RS19205	COG1309	transcriptional regulator
GPY27_RS19210	COG3706	GGDEF domain
GPY27_RS19220	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS19235	COG1024	Enoyl-CoA hydratase
GPY27_RS19240	COG1960	acyl-CoA dehydrogenase activity
GPY27_RS19250	COG0183	Belongs to the thiolase family
GPY27_RS19260	COG1960	acyl-CoA dehydrogenase activity
GPY27_RS19265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY27_RS19270	COG1024	Enoyl-CoA hydratase
GPY27_RS19285	COG2205	protein histidine kinase activity
GPY27_RS19285	COG3437	response regulator, receiver
GPY27_RS19285	COG4999	Histidine kinase
GPY27_RS19285	COG3850	Histidine kinase
GPY27_RS19300	COG3264	Mechanosensitive ion channel
GPY27_RS19300	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY27_RS19310	COG0110	maltose O-acetyltransferase activity
GPY27_RS19315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY27_RS19320	COG1271	oxidase subunit
GPY27_RS19325	COG1294	oxidase, subunit
GPY27_RS19335	COG0384	phenazine biosynthesis protein PhzF
GPY27_RS19340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY27_RS19345	COG0789	Transcriptional regulator
GPY27_RS19355	COG3474	cytochrome
GPY27_RS19425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY27_RS19440	COG3646	Phage regulatory protein
GPY27_RS19520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY27_RS19570	COG4695	Portal protein
GPY27_RS19660	COG0582	viral genome integration into host DNA
GPY27_RS19665	COG0516	GMP reductase activity
GPY27_RS19670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY27_RS19670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY27_RS19685	COG4989	oxidoreductase activity
GPY27_RS19700	COG0038	chloride channel
GPY27_RS19710	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY27_RS19715	COG0302	gtp cyclohydrolase
GPY27_RS19725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY27_RS19745	COG2897	thiosulfate sulfurtransferase activity
GPY27_RS19770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY27_RS19775	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY27_RS19780	COG0840	transmembrane signaling receptor activity
GPY27_RS19790	COG2814	Major facilitator Superfamily
GPY27_RS19795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY27_RS19805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY27_RS19815	COG0840	transmembrane signaling receptor activity
GPY27_RS19835	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY27_RS19850	COG2197	response regulator
GPY27_RS19855	COG3850	Histidine kinase
GPY27_RS19860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY27_RS19870	COG0243	molybdopterin cofactor binding
GPY27_RS19880	COG3005	denitrification pathway
GPY27_RS19900	COG0183	Belongs to the thiolase family
GPY27_RS19920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY27_RS19925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY27_RS19950	COG1522	sequence-specific DNA binding
GPY27_RS19970	COG1566	PFAM secretion protein HlyD family protein
GPY27_RS19980	COG0784	Response regulator, receiver
GPY27_RS19980	COG2205	protein histidine kinase activity
GPY27_RS19985	COG1879	ABC-type sugar transport system periplasmic component
GPY27_RS19990	COG2827	Endonuclease containing a URI domain
GPY27_RS19995	COG3132	Protein of unknown function, DUF480
GPY27_RS20010	COG2926	Belongs to the UPF0265 family
GPY27_RS20015	COG0534	Mate efflux family protein
GPY27_RS20020	COG0673	inositol 2-dehydrogenase activity
GPY27_RS20050	COG1522	sequence-specific DNA binding
GPY27_RS20060	COG0531	amino acid
GPY27_RS20075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY27_RS20080	COG2239	Acts as a magnesium transporter
GPY27_RS20090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY27_RS20095	COG0402	S-adenosylhomocysteine deaminase activity
GPY27_RS20105	COG1418	mRNA catabolic process
GPY27_RS20120	COG2814	Major facilitator Superfamily
GPY27_RS20130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY27_RS20150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY27_RS20170	COG4221	oxidoreductase activity
GPY27_RS20175	COG0745	RESPONSE REGULATOR receiver
GPY27_RS20180	COG2205	protein histidine kinase activity
GPY27_RS20190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY27_RS20195	COG2194	sulfuric ester hydrolase activity
GPY27_RS20200	COG0673	inositol 2-dehydrogenase activity
GPY27_RS20210	COG2814	Major facilitator Superfamily
GPY27_RS20225	COG1846	Transcriptional regulator
GPY27_RS20235	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY27_RS20240	COG1741	Belongs to the pirin family
GPY27_RS20245	COG1278	Cold shock
GPY27_RS20260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY27_RS20265	COG0678	peroxiredoxin activity
GPY27_RS20265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY27_RS20285	COG1686	Belongs to the peptidase S11 family
GPY27_RS20295	COG0625	glutathione transferase activity
GPY27_RS20305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY27_RS20315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY27_RS20335	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS20350	COG3746	phosphate-selective porin O and P
GPY27_RS20370	COG3833	ABC-type maltose transport systems, permease component
GPY27_RS20375	COG1175	transmembrane transport
GPY27_RS20385	COG3842	ATPase activity
GPY27_RS20450	COG1309	transcriptional regulator
GPY27_RS20455	COG2130	NADP-dependent
GPY27_RS20465	COG0753	catalase activity
GPY27_RS20470	COG2084	Dehydrogenase
GPY27_RS20475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY27_RS20480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY27_RS20490	COG2207	Transcriptional regulator
GPY27_RS20495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY27_RS20495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY27_RS20495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY27_RS20510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY27_RS20515	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY27_RS20520	COG5001	Diguanylate cyclase
GPY27_RS20520	COG3300	MHYT domain
GPY27_RS20525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY27_RS20530	COG0569	domain protein
GPY27_RS20540	COG5002	protein histidine kinase activity
GPY27_RS20545	COG1132	(ABC) transporter
GPY27_RS20550	COG4774	siderophore transport
GPY27_RS20555	COG1120	ATPase activity
GPY27_RS20560	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY27_RS20610	COG2197	response regulator
GPY27_RS20620	COG0840	transmembrane signaling receptor activity
GPY27_RS20630	COG0714	Associated with various cellular activities
GPY27_RS20650	COG2304	oxidoreductase activity
GPY27_RS20670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY27_RS20675	COG0581	inorganic phosphate transmembrane transporter activity
GPY27_RS20680	COG0573	inorganic phosphate transmembrane transporter activity
GPY27_RS20685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY27_RS20710	COG4771	TonB-dependent receptor
GPY27_RS20715	COG1770	oligopeptidase
GPY27_RS20720	COG0513	Belongs to the DEAD box helicase family
GPY27_RS20730	COG1376	ErfK ybiS ycfS ynhG family protein
GPY27_RS20730	COG1388	LysM domain
GPY27_RS20735	COG0415	Belongs to the DNA photolyase family
GPY27_RS20740	COG0789	Transcriptional regulator
GPY27_RS20745	COG3272	Protein of unknown function (DUF1722)
GPY27_RS20755	COG0813	purine-nucleoside phosphorylase activity
GPY27_RS20770	COG3706	GGDEF domain
GPY27_RS20780	COG1566	PFAM secretion protein HlyD family protein
GPY27_RS20785	COG4720	Psort location CytoplasmicMembrane, score
GPY27_RS20790	COG1122	ATPase activity
GPY27_RS20805	COG0348	domain, Protein
GPY27_RS20810	COG0437	4 iron, 4 sulfur cluster binding
GPY27_RS20815	COG1247	-acetyltransferase
GPY27_RS20845	COG1067	ATP-dependent peptidase activity
GPY27_RS20855	COG4172	Belongs to the ABC transporter superfamily
GPY27_RS20860	COG1505	serine-type exopeptidase activity
GPY27_RS20865	COG0583	DNA-binding transcription factor activity
GPY27_RS20870	COG1620	l-lactate permease
GPY27_RS20875	COG1304	FMN binding
GPY27_RS20885	COG0668	transmembrane transport
GPY27_RS20925	COG1063	alcohol dehydrogenase
GPY27_RS20930	COG0156	8-amino-7-oxononanoate synthase activity
GPY27_RS20940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY27_RS20960	COG0745	RESPONSE REGULATOR receiver
GPY27_RS20995	COG0346	lactoylglutathione lyase activity
GPY27_RS21015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY27_RS21055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY27_RS21070	COG2204	response regulator
GPY27_RS21095	COG1987	bacterial-type flagellum assembly
GPY27_RS21105	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY27_RS21120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY27_RS21130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY27_RS21135	COG1516	flagellar protein fliS
GPY27_RS21150	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY27_RS21155	COG1191	sigma factor activity
GPY27_RS21160	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY27_RS21165	COG1360	Flagellar Motor Protein
GPY27_RS21220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY27_RS21225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY27_RS21235	COG0454	-acetyltransferase
GPY27_RS21245	COG2814	Major facilitator Superfamily
GPY27_RS21290	COG0628	permease
GPY27_RS21295	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY27_RS21305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY27_RS21315	COG4628	conserved protein (DUF2132)
GPY27_RS21320	COG0583	DNA-binding transcription factor activity
GPY27_RS21345	COG1686	Belongs to the peptidase S11 family
GPY27_RS21365	COG3397	chitin binding
GPY27_RS21370	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY27_RS21375	COG2095	MarC family integral membrane protein
GPY27_RS21395	COG3206	protein involved in exopolysaccharide biosynthesis
GPY27_RS21395	COG0489	protein tyrosine kinase activity
GPY27_RS21410	COG0583	DNA-binding transcription factor activity
GPY27_RS21420	COG1301	dicarboxylic acid transport
GPY27_RS21425	COG3339	Conserved Protein
GPY27_RS21430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY27_RS21435	COG0700	Nucleoside recognition
GPY27_RS21440	COG3366	ferrous iron transmembrane transporter activity
GPY27_RS21455	COG0366	Alpha amylase catalytic
GPY27_RS21460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY27_RS21465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY27_RS21470	COG1640	4-alpha-glucanotransferase
GPY27_RS21475	COG0058	SHG alpha-glucan phosphorylase activity
GPY27_RS21490	COG2909	trisaccharide binding
GPY27_RS21505	COG1999	signal sequence binding
GPY27_RS21515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY27_RS21515	COG1263	PTS System
GPY27_RS21520	COG1162	GTPase activity
GPY27_RS21525	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY27_RS21535	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY27_RS21545	COG0531	amino acid
GPY27_RS21550	COG1982	Orn Lys Arg decarboxylase major
GPY27_RS21570	COG2356	endonuclease I
GPY27_RS21595	COG4580	involved in the transport of maltose and maltodextrins
GPY27_RS21620	COG0739	heme binding
GPY27_RS21630	COG0612	Peptidase, M16
GPY27_RS21635	COG0840	transmembrane signaling receptor activity
GPY27_RS21640	COG1120	ATPase activity
GPY27_RS21645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY27_RS21650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY27_RS21655	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY27_RS21660	COG4772	TonB-dependent receptor
GPY27_RS21685	COG4264	IucA IucC family
GPY27_RS21690	COG0019	diaminopimelate decarboxylase activity
GPY27_RS21695	COG1653	transport
GPY27_RS21705	COG0745	RESPONSE REGULATOR receiver
GPY27_RS21745	COG0463	Glycosyl transferase, family 2
GPY27_RS21765	COG1764	response to oxidative stress
GPY27_RS21770	COG1846	Transcriptional regulator
GPY27_RS21775	COG0450	alkyl hydroperoxide reductase
GPY27_RS21780	COG3634	alkyl hydroperoxide reductase activity
GPY27_RS21810	COG1595	DNA-templated transcription, initiation
GPY27_RS21825	COG0840	transmembrane signaling receptor activity
GPY27_RS21830	COG0583	DNA-binding transcription factor activity
GPY27_RS21835	COG1486	melibiose metabolic process
GPY27_RS21850	COG2258	MOSC domain
GPY27_RS21855	COG0513	Belongs to the DEAD box helicase family
GPY27_RS21865	COG2186	Transcriptional regulator
GPY27_RS21875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY27_RS21885	COG0246	Mannitol dehydrogenase
GPY27_RS21890	COG1904	glucuronate isomerase
GPY27_RS21895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY27_RS21900	COG0800	Aldolase
GPY27_RS21925	COG2207	Transcriptional regulator
GPY27_RS21935	COG1132	(ABC) transporter
GPY27_RS21980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY27_RS22010	COG0259	pyridoxamine-phosphate oxidase activity
GPY27_RS22055	COG4166	transmembrane transport
GPY27_RS22075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY27_RS22080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY27_RS22080	COG1263	PTS System
GPY27_RS22085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY27_RS22090	COG3340	Belongs to the peptidase S51 family
GPY27_RS22110	COG1444	tRNA N-acetyltransferase activity
GPY27_RS22135	COG4608	Belongs to the ABC transporter superfamily
GPY27_RS22140	COG0444	Belongs to the ABC transporter superfamily
GPY27_RS22150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY27_RS22150	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY27_RS22175	COG0217	transcriptional regulatory protein
GPY27_RS22180	COG0772	Belongs to the SEDS family
GPY27_RS22195	COG1136	(ABC) transporter
GPY27_RS22215	COG3275	phosphorelay sensor kinase activity
GPY27_RS22220	COG3279	Response regulator of the LytR AlgR family
GPY27_RS22230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY27_RS22265	COG0786	glutamate:sodium symporter activity
GPY27_RS22275	COG1131	(ABC) transporter
GPY27_RS22280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY27_RS22285	COG0786	glutamate:sodium symporter activity
GPY27_RS22300	COG0363	glucosamine-6-phosphate deaminase activity
GPY27_RS22320	COG1741	Belongs to the pirin family
GPY27_RS22325	COG2259	Doxx family
GPY27_RS22340	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY27_RS22345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY27_RS22355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY27_RS22395	COG3123	guanosine phosphorylase activity
GPY27_RS22405	COG5001	Diguanylate cyclase
GPY27_RS22415	COG0534	Mate efflux family protein
GPY27_RS22420	COG0564	pseudouridine synthase activity
GPY27_RS22435	COG0583	DNA-binding transcription factor activity
GPY27_RS22440	COG0561	phosphatase activity
GPY27_RS22450	COG2199	diguanylate cyclase activity
GPY27_RS22465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY27_RS22470	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY27_RS22475	COG0583	DNA-binding transcription factor activity
GPY27_RS22490	COG1414	Transcriptional regulator
GPY27_RS22495	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS22505	COG1917	Cupin 2, conserved barrel domain protein
GPY27_RS22520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY27_RS22525	COG0800	Aldolase
GPY27_RS22545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY27_RS22550	COG0823	Involved in the tonB-independent uptake of proteins
GPY27_RS22555	COG2375	cellular response to nickel ion
GPY27_RS22585	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY27_RS22590	COG3047	cAMP biosynthetic process
GPY27_RS22620	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GPY27_RS22620	COG3408	Glycogen debranching enzyme
GPY27_RS22625	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GPY27_RS22635	COG0583	DNA-binding transcription factor activity
GPY27_RS22645	COG0583	DNA-binding transcription factor activity
GPY27_RS22660	COG0546	phosphoglycolate phosphatase activity
GPY27_RS22685	COG3835	regulator
GPY27_RS22695	COG1929	Belongs to the glycerate kinase type-1 family
GPY27_RS22700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY27_RS22720	COG0456	acetyltransferase
GPY27_RS22735	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS22745	COG3005	denitrification pathway
GPY27_RS22750	COG0243	molybdopterin cofactor binding
GPY27_RS22760	COG0352	thiamine-phosphate diphosphorylase activity
GPY27_RS22765	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GPY27_RS22770	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY27_RS22775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY27_RS22780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY27_RS22785	COG1116	anion transmembrane transporter activity
GPY27_RS22790	COG0351	phosphomethylpyrimidine kinase
GPY27_RS22800	COG0312	modulator of DNA gyrase
GPY27_RS22805	COG0312	modulator of DNA gyrase
GPY27_RS22810	COG1901	pseudouridine methyltransferase
GPY27_RS22870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY27_RS22880	COG0584	glycerophosphoryl diester phosphodiesterase
GPY27_RS22890	COG0745	RESPONSE REGULATOR receiver
GPY27_RS22910	COG0811	peptide transport
GPY27_RS22915	COG0811	peptide transport
GPY27_RS22920	COG0848	biopolymer transport protein
GPY27_RS22960	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPY27_RS22965	COG1121	(ABC) transporter
GPY27_RS22970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY27_RS22985	COG1770	oligopeptidase
GPY27_RS22990	COG2814	Major facilitator Superfamily
GPY27_RS22995	COG0010	Belongs to the arginase family
GPY27_RS23000	COG1166	arginine decarboxylase activity
GPY27_RS23010	COG4067	protein conserved in archaea
GPY27_RS23010	COG0189	ligase activity
GPY27_RS23015	COG0189	ligase activity
GPY27_RS23025	COG0583	DNA-binding transcription factor activity
GPY27_RS23070	COG3706	GGDEF domain
GPY27_RS23075	COG1114	Component of the transport system for branched-chain amino acids
GPY27_RS23100	COG0579	oxidoreductase
GPY27_RS23110	COG3033	Beta-eliminating lyase
GPY27_RS23130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY27_RS23140	COG3145	DNA-N1-methyladenine dioxygenase activity
GPY27_RS23145	COG3706	GGDEF domain
GPY27_RS23150	COG0840	transmembrane signaling receptor activity
GPY27_RS23165	COG3706	GGDEF domain
GPY27_RS23170	COG0415	Belongs to the DNA photolyase family
GPY27_RS23175	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY27_RS23190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY27_RS23190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY27_RS23195	COG1765	OsmC-like protein
GPY27_RS23200	COG0110	maltose O-acetyltransferase activity
GPY27_RS23240	COG1011	Hydrolase
GPY27_RS23255	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY27_RS23260	COG3338	carbonate dehydratase activity
GPY27_RS23265	COG2067	long-chain fatty acid transport protein
GPY27_RS23270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY27_RS23275	COG1136	(ABC) transporter
GPY27_RS23275	COG0577	efflux transmembrane transporter activity
GPY27_RS23285	COG3240	lipase activity
GPY27_RS23315	COG1609	Transcriptional regulator
GPY27_RS23320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY27_RS23330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY27_RS23335	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY27_RS23345	COG3842	ATPase activity
GPY27_RS23370	COG2990	Protein conserved in bacteria
GPY27_RS23380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY27_RS23385	COG2866	Carboxypeptidase
GPY27_RS23400	COG0583	DNA-binding transcription factor activity
GPY27_RS23425	COG1760	l-serine dehydratase
GPY27_RS23445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY27_RS23455	COG0741	lytic transglycosylase activity
GPY27_RS23475	COG1815	bacterial-type flagellum-dependent cell motility
GPY27_RS23480	COG1558	bacterial-type flagellum-dependent cell motility
GPY27_RS23485	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY27_RS23490	COG1749	Flagellar hook protein flgE
GPY27_RS23495	COG4787	bacterial-type flagellum-dependent cell motility
GPY27_RS23500	COG4786	Flagellar basal body rod
GPY27_RS23505	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY27_RS23510	COG1706	bacterial-type flagellum-dependent cell motility
GPY27_RS23520	COG1256	bacterial-type flagellum assembly
GPY27_RS23520	COG4786	Flagellar basal body rod
GPY27_RS23525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY27_RS23545	COG1304	FMN binding
GPY27_RS23570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY27_RS23580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY27_RS23585	COG0459	protein refolding
GPY27_RS23600	COG1280	lysine exporter protein (LysE YggA)
GPY27_RS23620	COG1309	transcriptional regulator
GPY27_RS23630	COG0737	Belongs to the 5'-nucleotidase family
GPY27_RS23635	COG2070	2-Nitropropane dioxygenase
GPY27_RS23640	COG3537	Alpha-1,2-mannosidase
GPY27_RS23645	COG3537	Alpha-1,2-mannosidase
GPY27_RS23655	COG3537	Alpha-1,2-mannosidase
GPY27_RS23660	COG3537	Alpha-1,2-mannosidase
GPY27_RS23665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY27_RS23690	COG0346	lactoylglutathione lyase activity
GPY27_RS23695	COG1349	DNA-binding transcription factor activity
GPY27_RS23705	COG0753	catalase activity
GPY27_RS23715	COG1335	isochorismatase
GPY27_RS23725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY27_RS23750	COG0583	DNA-binding transcription factor activity
GPY27_RS23765	COG3713	MltA-interacting MipA family protein
GPY27_RS23775	COG3015	lipoprotein NlpE involved in copper resistance
GPY27_RS23785	COG1342	Belongs to the UPF0251 family
GPY27_RS23810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY27_RS23820	COG4948	Mandelate Racemase Muconate Lactonizing
GPY27_RS23830	COG0583	DNA-binding transcription factor activity
GPY27_RS23880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY27_RS23925	COG3842	ATPase activity
GPY27_RS23955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY27_RS23975	COG3706	GGDEF domain
GPY27_RS23995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY27_RS24010	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY27_RS24015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY27_RS24035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY27_RS24035	COG0574	Belongs to the PEP-utilizing enzyme family
GPY27_RS24040	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY27_RS24045	COG0252	asparaginase activity
GPY27_RS24055	COG0583	DNA-binding transcription factor activity
GPY27_RS24070	COG3122	Protein conserved in bacteria
GPY27_RS24085	COG1028	Short-chain dehydrogenase reductase Sdr
GPY27_RS24095	COG1063	alcohol dehydrogenase
GPY27_RS24100	COG1902	pentaerythritol trinitrate reductase activity
GPY27_RS24115	COG0583	DNA-binding transcription factor activity
GPY27_RS24125	COG0513	Belongs to the DEAD box helicase family
GPY27_RS24170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY27_RS24175	COG2207	Transcriptional regulator
GPY27_RS24175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY27_RS24195	COG4753	response regulator
GPY27_RS24195	COG2207	Transcriptional regulator
GPY27_RS24205	COG2354	Protein conserved in bacteria
GPY27_RS24210	COG0418	dihydroorotase activity
GPY27_RS24220	COG0401	homolog of Blt101
GPY27_RS24230	COG0633	Ferredoxin
GPY27_RS24230	COG0633	Ferredoxin
GPY27_RS24230	COG3217	Mosc domain protein beta barrel domain protein
GPY27_RS24230	COG3217	Mosc domain protein beta barrel domain protein
GPY27_RS24235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY27_RS24240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY27_RS24280	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY27_RS24285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY27_RS24295	COG0848	biopolymer transport protein
GPY27_RS24300	COG0811	peptide transport
GPY27_RS24305	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY27_RS24315	COG3721	Heme iron utilization protein
GPY27_RS24320	COG0748	coenzyme F420 binding
GPY27_RS24330	COG0835	chemotaxis
GPY27_RS24330	COG0784	Response regulator, receiver
GPY27_RS24340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY27_RS24350	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GPY27_RS24350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY27_RS24375	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY27_RS24380	COG0783	Belongs to the Dps family
GPY27_RS24390	COG0583	DNA-binding transcription factor activity
GPY27_RS24405	COG4934	collagen metabolic process
GPY27_RS24415	COG0366	Alpha amylase catalytic
GPY27_RS24435	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY27_RS24440	COG0589	response to stress
GPY27_RS24445	COG0488	(ABC) transporter
GPY27_RS24450	COG1505	serine-type exopeptidase activity
GPY27_RS24460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY27_RS24470	COG2067	long-chain fatty acid transport protein
GPY27_RS24480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY27_RS24490	COG2199	diguanylate cyclase activity
GPY27_RS24490	COG2203	Gaf domain
GPY27_RS24535	COG3383	formate dehydrogenase (NAD+) activity
GPY27_RS24550	COG0842	Transport permease protein
GPY27_RS24555	COG1131	(ABC) transporter
GPY27_RS24570	COG2706	6-phosphogluconolactonase activity
GPY27_RS24580	COG1881	PFAM PEBP family protein
GPY27_RS24590	COG0798	PFAM Bile acid sodium symporter
GPY27_RS24610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY27_RS24615	COG2213	PTS system mannitol-specific
GPY27_RS24620	COG1063	alcohol dehydrogenase
GPY27_RS24630	COG1072	(Pantothenic acid kinase))
GPY27_RS24635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY27_RS24655	COG0814	amino acid
GPY27_RS24695	COG0739	heme binding
GPY27_RS24700	COG5001	Diguanylate cyclase
GPY27_RS24705	COG0583	DNA-binding transcription factor activity
GPY27_RS24710	COG2814	Major facilitator Superfamily
GPY27_RS24735	COG0697	spore germination
GPY27_RS24765	COG2207	Transcriptional regulator
GPY27_RS24770	COG1280	lysine exporter protein (LysE YggA)
GPY27_RS24780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY27_RS24785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY27_RS24795	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY27_RS24820	COG1612	heme a metabolic process