locus-tag class description GPY31_RS00030 ENOG4108WQH regulatoR GPY31_RS00040 ENOG4105BZU Histidine kinase GPY31_RS00045 ENOG4108WQH regulatoR GPY31_RS00050 ENOG4105BZU Histidine kinase GPY31_RS00055 ENOG4105BZU Histidine kinase GPY31_RS00065 ENOG41064T2 transcriptional regulator, lysR family GPY31_RS00080 ENOG4105CDV Ompa motb domain protein GPY31_RS00165 ENOG4105KXC Collagenase GPY31_RS00185 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 GPY31_RS00215 ENOG4105CVR type I restriction-modification system GPY31_RS00220 ENOG4107SCJ type I restriction enzyme EcoKI subunit R GPY31_RS00255 ENOG4105CGH 5'-nucleotidase GPY31_RS00260 ENOG4108NZE NAGC-like transcriptional regulator GPY31_RS00270 ENOG4107QNK )-transporter GPY31_RS00275 ENOG4107HQ7 repeat protein GPY31_RS00320 ENOG4108M3R transcriptional activator CadC GPY31_RS00340 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase GPY31_RS00345 ENOG4105YGP holo-ACP synthase CitX GPY31_RS00350 ENOG4105CHY citrate lyase, alpha GPY31_RS00355 ENOG4105CI0 Citrate lyase GPY31_RS00360 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) GPY31_RS00365 ENOG4105DUA (citrate (pro-3S)-lyase ligase GPY31_RS00380 ENOG4107QSA Oxaloacetate decarboxylase GPY31_RS00385 ENOG4105D9Q decarboxylase (Beta subunit) GPY31_RS00390 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPY31_RS00395 ENOG4106YYS transcriptional regulatory protein GPY31_RS00410 ENOG4108YGG dna repair protein GPY31_RS00445 ENOG4105C4X radical SAM domain protein GPY31_RS00450 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) GPY31_RS00460 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GPY31_RS00465 ENOG4107KBT 8-Amino-7-oxononanoate synthase GPY31_RS00470 ENOG4108MGY Histidine kinase GPY31_RS00490 ENOG4105CEE C4-dicarboxylate transporter GPY31_RS00495 ENOG4108V0P LemA family GPY31_RS00500 ENOG4105D0M Protease HtpX homolog GPY31_RS00520 ENOG4105F2V VRR-NUC domain-containing protein GPY31_RS00530 ENOG4105C4X radical SAM domain protein GPY31_RS00550 ENOG4108YDI single-species biofilm formation on inanimate substrate GPY31_RS00555 ENOG4107TE5 Lipid kinase GPY31_RS00560 ENOG41064T2 transcriptional regulator, lysR family GPY31_RS00565 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GPY31_RS00595 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GPY31_RS00600 ENOG4105C4X radical SAM domain protein GPY31_RS00605 ENOG4105ENH Sulfatase GPY31_RS00620 ENOG4105ENH Sulfatase GPY31_RS00625 ENOG4105ENH Sulfatase GPY31_RS00630 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY31_RS00645 ENOG4105BZU Histidine kinase GPY31_RS00650 ENOG4108SV3 Tmao reductase system periplasmic protein tort GPY31_RS00655 ENOG4108Z5K methylglyoxal synthase GPY31_RS00660 ENOG41088T4 Helicase IV GPY31_RS00665 ENOG4105EM2 membrane GPY31_RS00715 ENOG4108Z6Z Transcriptional regulator GPY31_RS00720 ENOG4108IPW abc transporter atp-binding protein GPY31_RS00725 ENOG4105CM4 permease protein GPY31_RS00730 ENOG4105DHS permease protein GPY31_RS00760 ENOG4106E5D Protein of unknown function (DUF461) GPY31_RS00765 ENOG4105R8A Heat shock protein GPY31_RS00780 ENOG4107RUY (E1 component), alpha subunit GPY31_RS00785 ENOG4105CPP Dehydrogenase, E1 component GPY31_RS00790 ENOG4107QSN dihydrolipoamide acetyltransferase GPY31_RS00800 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GPY31_RS00805 ENOG4107MKT Stringent starvation protein a GPY31_RS00810 ENOG4105DUM transcriptional regulator, lysR family GPY31_RS00820 ENOG4105DMR ABC, transporter GPY31_RS00825 ENOG4105GBT ABC transporter GPY31_RS00830 ENOG4106PMH Extracellular solute-binding protein family 3 GPY31_RS00835 ENOG4105E5Z arginine transporter ATP-binding subunit GPY31_RS00865 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY31_RS00880 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GPY31_RS00890 ENOG4105CCU oxidase (Subunit III) GPY31_RS00895 ENOG4105BZ9 Cytochrome C oxidase, subunit I GPY31_RS00900 ENOG4105E2S oxidase) subunit II GPY31_RS00905 ENOG4105CHR reductase GPY31_RS00910 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPY31_RS00915 ENOG4105E39 Enoyl-CoA hydratase GPY31_RS00920 ENOG4105E39 Enoyl-CoA hydratase GPY31_RS00930 ENOG4105C26 Dehydrogenase GPY31_RS00935 ENOG4105CHU acetyl-coa acetyltransferase GPY31_RS00945 ENOG4105C1G acyl-Coa dehydrogenase GPY31_RS00950 ENOG4107QX3 carboxylase GPY31_RS00955 ENOG4105CGU Enoyl-CoA hydratase GPY31_RS00960 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GPY31_RS00975 ENOG4107SDU Methyl-accepting chemotaxis GPY31_RS00980 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPY31_RS00990 ENOG4105BZU Histidine kinase GPY31_RS00995 ENOG4105C1J atp-dependent rna helicase GPY31_RS01000 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) GPY31_RS01015 ENOG4107S17 Phosphate-binding protein GPY31_RS01035 ENOG4105C4X radical SAM domain protein GPY31_RS01040 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) GPY31_RS01045 ENOG4105DUM transcriptional regulator, lysR family GPY31_RS01060 ENOG4108N3W hemolysin secretion protein GPY31_RS01065 ENOG4105DKW ABC transporter GPY31_RS01070 ENOG4105CXC rtn protein GPY31_RS01090 ENOG4105C1J atp-dependent rna helicase GPY31_RS01095 ENOG4105CKI cobalamin synthesis protein GPY31_RS01105 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GPY31_RS01115 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GPY31_RS01120 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GPY31_RS01125 ENOG4105C1J atp-dependent rna helicase GPY31_RS01130 ENOG4105VRT cytoplasmic protein GPY31_RS01155 ENOG41090A4 Pterin carbinolamine dehydratase GPY31_RS01160 ENOG4105MIR Phenylalanine 4-monooxygenase GPY31_RS01165 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY31_RS01170 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GPY31_RS01210 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GPY31_RS01215 ENOG4105C0A alcohol dehydrogenase GPY31_RS01230 ENOG4108RMU ferritin dps family protein GPY31_RS01235 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS01245 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY31_RS01265 ENOG4105BZU Histidine kinase GPY31_RS01275 ENOG4107SDU Methyl-accepting chemotaxis GPY31_RS01285 ENOG4105VEQ Cold shock protein GPY31_RS01320 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY31_RS01325 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GPY31_RS01330 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GPY31_RS01350 ENOG4107QS1 Cytochrome C Oxidase, Subunit III GPY31_RS01355 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) GPY31_RS01415 ENOG4108SXK Transporter Drug Metabolite Exporter family GPY31_RS01420 ENOG4105VW4 glutaredoxin 3 GPY31_RS01440 ENOG4105E5M Multidrug resistance protein D GPY31_RS01445 ENOG4105CR8 Transcriptional regulator GPY31_RS01455 ENOG4105DR5 peptidase GPY31_RS01480 ENOG4105DWD nucleoside recognition domain protein GPY31_RS01485 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS01495 ENOG4105E0U tyrosine-specific transport protein GPY31_RS01520 ENOG4107Z1W Fructose transport system kinase GPY31_RS01530 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein GPY31_RS01535 ENOG4105CTS PTS system mannitol-specific GPY31_RS01540 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GPY31_RS01560 ENOG4105D6J arsenicaL-resistance protein GPY31_RS01570 ENOG4108V1U phospholipid-binding protein GPY31_RS01575 ENOG4105JAB phenazine biosynthesis protein, phzf family GPY31_RS01580 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GPY31_RS01585 ENOG4108NVR Methyl-accepting chemotaxis GPY31_RS01595 ENOG4105CJ1 ABC, transporter GPY31_RS01600 ENOG4107QWP ABC-2 type transporter GPY31_RS01615 ENOG4108IEG Formate dehydrogenase Alpha subunit GPY31_RS01640 ENOG4108IJF Heavy metal efflux pump, CzcA GPY31_RS01660 ENOG410620I Diguanylate cyclase GPY31_RS01670 ENOG4108HK0 -acetyltransferase GPY31_RS01680 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY31_RS01690 ENOG4105ENT Efflux transporter rnd family, mfp subunit GPY31_RS01705 ENOG4105C5H ABC transporter GPY31_RS01710 ENOG4108M6U Universal stress protein A GPY31_RS01715 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GPY31_RS01720 ENOG4105CKD glutathione-regulated potassium-efflux system protein GPY31_RS01745 ENOG4105KXC Collagenase GPY31_RS01760 ENOG4105C5Q Transcriptional regulator GPY31_RS01775 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GPY31_RS01800 ENOG4108K2B transcriptional regulator GPY31_RS01805 ENOG4105F8D glycoside hydrolase family 4 GPY31_RS01810 ENOG4105CT4 transporter GPY31_RS01825 ENOG4105EQR Transposase IS116 IS110 IS902 GPY31_RS01835 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY31_RS01865 ENOG4107TII Recombinase GPY31_RS01870 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GPY31_RS01880 ENOG4107R88 Chemotaxis protein (CheV) GPY31_RS01890 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related GPY31_RS01895 ENOG41090JE Utilization Protein GPY31_RS01900 ENOG4105D4P Coproporphyrinogen iii oxidase GPY31_RS01905 ENOG4105WQ5 TonB family GPY31_RS01910 ENOG41090AP transport protein GPY31_RS01915 ENOG4106GFD transport protein GPY31_RS01925 ENOG4105EHG Permease protein GPY31_RS01930 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS01970 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GPY31_RS01975 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GPY31_RS01980 ENOG4105QVC MOSC domain-containing protein GPY31_RS01980 ENOG4105QVC MOSC domain-containing protein GPY31_RS02000 ENOG4105EKE dihydroorotase GPY31_RS02005 ENOG4105CKW Inner membrane protein yedI GPY31_RS02035 ENOG410874W AraC family transcriptional regulator GPY31_RS02040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY31_RS02085 ENOG4105C1J atp-dependent rna helicase GPY31_RS02095 ENOG4107RSM transcriptional regulator GPY31_RS02110 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY31_RS02115 ENOG4105CPQ Dehydrogenase GPY31_RS02125 ENOG4105CHR reductase GPY31_RS02130 ENOG4108ZX5 transcriptional regulator GPY31_RS02140 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme GPY31_RS02160 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GPY31_RS02165 ENOG4105HDK L-asparaginase GPY31_RS02170 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GPY31_RS02175 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GPY31_RS02195 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GPY31_RS02200 ENOG4107RUE extracellular solute-binding protein family 1 GPY31_RS02215 ENOG4107KET secretion protein, HlyD family GPY31_RS02235 ENOG4105BZU Histidine kinase GPY31_RS02245 ENOG41086KC Transcriptional regulator GPY31_RS02285 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS02335 ENOG4107RZC phospholipase d GPY31_RS02365 ENOG4108Z4X TRANSCRIPTIONal GPY31_RS02385 ENOG4105RQF LysR family Transcriptional regulator GPY31_RS02395 ENOG4107S8C mandelate racemase muconate lactonizing GPY31_RS02405 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPY31_RS02430 ENOG4105VYW UPF0251 protein GPY31_RS02440 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion GPY31_RS02450 ENOG4105RW8 MltA-interacting MipA family protein GPY31_RS02465 ENOG4105ETT transcriptional Regulator, LysR family GPY31_RS02495 ENOG4107RH7 Nicotinate phosphoribosyltransferase GPY31_RS02505 ENOG4108RWI nicotinamidase GPY31_RS02515 ENOG4105CH6 catalase GPY31_RS02525 ENOG4105N2W Transcriptional regulator GPY31_RS02530 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GPY31_RS02535 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GPY31_RS02545 ENOG4105DM4 PTS System GPY31_RS02550 ENOG4105EA8 2-Nitropropane dioxygenase GPY31_RS02555 ENOG4105CGH 5'-nucleotidase GPY31_RS02565 ENOG4107Z3H Transcriptional regulator, TetR family GPY31_RS02585 ENOG4105N14 lysine exporter protein LysE YggA GPY31_RS02600 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPY31_RS02605 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GPY31_RS02615 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GPY31_RS02645 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GPY31_RS02665 ENOG4105DTJ flagellar hook-associated protein GPY31_RS02670 ENOG4105E1Q flagellar hook-associated protein GPY31_RS02675 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GPY31_RS02680 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY31_RS02685 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY31_RS02690 ENOG4105CGA flagellar basal-body rod protein FlgG GPY31_RS02695 ENOG4108KPB Flagellar basal-body rod protein FlgF GPY31_RS02700 ENOG4105BZE flagellar hook protein, FlgE GPY31_RS02705 ENOG4105W00 Flagellar hook capping protein GPY31_RS02710 ENOG4108ZC9 flagellar basal-body rod protein flgc GPY31_RS02715 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GPY31_RS02735 ENOG4105E4C Lytic transglycosylase catalytic GPY31_RS02745 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GPY31_RS02765 ENOG4105EJQ L-serine dehydratase GPY31_RS02770 ENOG4105DUX Transporter GPY31_RS02790 ENOG4105ETT transcriptional Regulator, LysR family GPY31_RS02810 ENOG4105CJP fad dependent oxidoreductase GPY31_RS02820 ENOG4108MJ5 VirK protein GPY31_RS02840 ENOG4107RCV ABC transporter, permease GPY31_RS02860 ENOG4107STF Involved in phosphonate degradation (By similarity) GPY31_RS02865 ENOG4108JPW Aminotransferase GPY31_RS02870 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GPY31_RS02875 ENOG4105ETE Transcriptional regulator (LacI family GPY31_RS02900 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GPY31_RS02905 ENOG4105KUU lipolytic protein G-D-S-L family GPY31_RS02915 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY31_RS02925 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY31_RS02935 ENOG4108UUE Transcriptional regulator GPY31_RS02950 ENOG4105PAD Hydrolase GPY31_RS02955 ENOG4105JQN Transcriptional regulator GPY31_RS02990 ENOG4108UW5 maltose o-acetyltransferase GPY31_RS02995 ENOG4108UKZ OsmC family GPY31_RS03000 ENOG4105E0X reductase GPY31_RS03015 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GPY31_RS03020 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY31_RS03025 ENOG4106TD9 Diguanylate cyclase GPY31_RS03045 ENOG4105BZU Histidine kinase GPY31_RS03050 ENOG4105CF1 Alkylated DNA repair protein GPY31_RS03060 ENOG4105D9N nucleoside GPY31_RS03080 ENOG4105C0F tryptophanase EC 4.1.99.1 GPY31_RS03090 ENOG4105D5U fad dependent oxidoreductase GPY31_RS03115 ENOG4105CWM branched-chain amino acid transport system II carrier protein GPY31_RS03120 ENOG4105BZU Histidine kinase GPY31_RS03125 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS03130 ENOG4105CQZ Histidine kinase GPY31_RS03165 ENOG4105DUM transcriptional regulator, lysR family GPY31_RS03175 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY31_RS03180 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY31_RS03190 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) GPY31_RS03195 ENOG4105CYW agmatinase GPY31_RS03200 ENOG4105E5M Multidrug resistance protein D GPY31_RS03205 ENOG4105CUG Oligopeptidase b GPY31_RS03220 ENOG4105CC5 ABC transporter GPY31_RS03225 ENOG4105DIK (ABC) transporter GPY31_RS03230 ENOG4105DSE periplasmic solute binding protein GPY31_RS03270 ENOG4109015 Biopolymer transport protein exbD tolR GPY31_RS03295 ENOG410804D Sensor Signal Transduction Histidine Kinase GPY31_RS03300 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY31_RS03305 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GPY31_RS03310 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GPY31_RS03320 ENOG4105C5I Dehydrogenase GPY31_RS03325 ENOG4108YYI Protein of unknown function (DUF2810) GPY31_RS03380 ENOG4108TEM pseudouridine methyltransferase GPY31_RS03400 ENOG4105DWF phosphomethylpyrimidine kinase GPY31_RS03405 ENOG4108YI8 ABC transporter GPY31_RS03410 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component GPY31_RS03415 ENOG4107Z6I Thiamine biosynthesis protein GPY31_RS03420 ENOG4105ETU transcriptional activator (TenA GPY31_RS03425 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GPY31_RS03430 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GPY31_RS03440 ENOG4107QY8 reductase GPY31_RS03445 ENOG4105CUW cytochrome C-TYPE protein GPY31_RS03455 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GPY31_RS03490 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY31_RS03495 ENOG4105BZW Glycerate kinase GPY31_RS03500 ENOG4105C6Z Gluconate GPY31_RS03505 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GPY31_RS03530 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 GPY31_RS03555 ENOG4108WAV Transcriptional regulator GPY31_RS03560 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GPY31_RS03565 ENOG4108UVJ appr-1-p processing domain protein GPY31_RS03570 ENOG4107WCA isomerase GPY31_RS03590 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPY31_RS03600 ENOG4105EIF outer membrane protein W GPY31_RS03605 ENOG4107W31 Pentapeptide repeat protein GPY31_RS03620 ENOG4108M1A Chitin-binding protein GPY31_RS03625 ENOG4105EW9 transcriptional regulator AsnC family GPY31_RS03635 ENOG4105Q26 Siderophore-interacting protein GPY31_RS03640 ENOG4105CAZ oligogalacturonide lyase GPY31_RS03665 ENOG4108UHU Aldolase GPY31_RS03670 ENOG4107SS6 2-dehydro-3-deoxygluconokinase GPY31_RS03685 ENOG4105M5J Cupin 2, conserved barrel domain protein GPY31_RS03690 ENOG4105P66 Membrane GPY31_RS03695 ENOG4105CHR reductase GPY31_RS03700 ENOG4105J4Q Transcriptional regulator GPY31_RS03715 ENOG4105CC0 LysR family Transcriptional regulator GPY31_RS03720 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GPY31_RS03730 ENOG4105C4W S-formylglutathione hydrolase GPY31_RS03740 ENOG4108KHX Diguanylate cyclase GPY31_RS03750 ENOG4108HCJ Hydrolase GPY31_RS03755 ENOG4105EJC lysr family transcriptional regulator GPY31_RS03770 ENOG4105D3G Pseudouridine synthase GPY31_RS03775 ENOG4105UQX Mate efflux family protein GPY31_RS03785 ENOG4108K0B C-di-gmp phosphodiesterase GPY31_RS03795 ENOG4105NBK UPF0345 protein GPY31_RS03825 ENOG4105DN9 Na H antiporter GPY31_RS03845 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GPY31_RS03850 ENOG4105D03 DNA-3-methyladenine glycosylase II GPY31_RS03865 ENOG4105NQG DoxX GPY31_RS03890 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GPY31_RS03905 ENOG4105D6U Sodium Glutamate Symporter GPY31_RS03910 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY31_RS03915 ENOG4105DVE abc transporter atp-binding protein GPY31_RS03925 ENOG4105D6U Sodium Glutamate Symporter GPY31_RS03955 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS03960 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY31_RS03970 ENOG4108VAC response regulator GPY31_RS03975 ENOG4108HRK Histidine kinase GPY31_RS03995 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GPY31_RS04010 ENOG4105CNI cell division protein FtsW GPY31_RS04015 ENOG4105CDY transcriptional regulatory protein GPY31_RS04025 ENOG4105BZU Histidine kinase GPY31_RS04055 ENOG4108JQ7 (ABC) transporter GPY31_RS04075 ENOG4106RMF ParB family GPY31_RS04080 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) GPY31_RS04095 ENOG4105EQ2 LysR family Transcriptional regulator GPY31_RS04100 ENOG4105EC3 peptidase S51, dipeptidase E GPY31_RS04105 ENOG4105FCK Membrane GPY31_RS04110 ENOG4105C5Y PTS System GPY31_RS04115 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GPY31_RS04125 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) GPY31_RS04135 ENOG4108J59 Extracellular solute-binding protein, family 5 GPY31_RS04150 ENOG4108JJA ABC, transporter GPY31_RS04165 ENOG4107QZV Type I secretion membrane fusion protein GPY31_RS04170 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS04175 ENOG4105CQZ Histidine kinase GPY31_RS04180 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GPY31_RS04200 ENOG4105C26 Dehydrogenase GPY31_RS04210 ENOG4105CK7 Sodium proline symporter GPY31_RS04245 ENOG4105EW9 transcriptional regulator AsnC family GPY31_RS04255 ENOG4105BZ1 (ABC) transporter GPY31_RS04280 ENOG4105C1J atp-dependent rna helicase GPY31_RS04285 ENOG4108RPX mosc domain containing protein GPY31_RS04300 ENOG4105F8D glycoside hydrolase family 4 GPY31_RS04305 ENOG4105ETT transcriptional Regulator, LysR family GPY31_RS04310 ENOG4108N3W hemolysin secretion protein GPY31_RS04325 ENOG4105DU6 RNA polymerase GPY31_RS04330 ENOG4105ECQ AraC Family Transcriptional Regulator GPY31_RS04340 ENOG4105EXG Transcriptional regulator GPY31_RS04355 ENOG4108JU3 Alkyl hydroperoxide reductase GPY31_RS04360 ENOG4105D3R alkyl hydroperoxide reductase GPY31_RS04365 ENOG4105K56 Transcriptional regulator GPY31_RS04370 ENOG4108ZHJ Organic hydroperoxide resistance protein GPY31_RS04395 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GPY31_RS04405 ENOG4105EF1 ribulokinase GPY31_RS04410 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator GPY31_RS04415 ENOG4105C2J ABC transporter GPY31_RS04420 ENOG4105CNN ABC, transporter GPY31_RS04435 ENOG4105CI1 PTS System GPY31_RS04445 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY31_RS04450 ENOG4105DHQ Histidine kinase GPY31_RS04455 ENOG4108JP0 extracellular solute-binding protein family 1 GPY31_RS04460 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GPY31_RS04465 ENOG4105DBM Siderophore biosynthesis protein GPY31_RS04475 ENOG4105DUU IucA IucC family protein GPY31_RS04485 ENOG4105E0K tonB-dependent siderophore receptor GPY31_RS04490 ENOG4105GAV receptor GPY31_RS04495 ENOG4108HUF Transporter GPY31_RS04500 ENOG4105DQ5 transport system permease protein GPY31_RS04505 ENOG4108U1V ABC transporter, permease GPY31_RS04510 ENOG4105E0A ABC, transporter GPY31_RS04515 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS04520 ENOG4107RAN Peptidase, M16 GPY31_RS04530 ENOG4105DR5 peptidase GPY31_RS04540 ENOG4105E5M Multidrug resistance protein D GPY31_RS04555 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GPY31_RS04580 ENOG4108K8S endonuclease I GPY31_RS04600 ENOG4105CXN decarboxylase GPY31_RS04605 ENOG4105D5Q Arginine ornithine antiporter GPY31_RS04615 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) GPY31_RS04625 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GPY31_RS04630 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GPY31_RS04660 ENOG41061ZR Transcriptional regulator GPY31_RS04675 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GPY31_RS04680 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GPY31_RS04685 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GPY31_RS04690 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase GPY31_RS04695 ENOG4107T9C Alpha amylase catalytic region GPY31_RS04710 ENOG41074DU domain protein GPY31_RS04715 ENOG4108P2H Inner membrane protein YjiG GPY31_RS04720 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GPY31_RS04730 ENOG4105CK2 sodium dicarboxylate symporter GPY31_RS04740 ENOG4105F04 LysR family Transcriptional regulator GPY31_RS04745 ENOG4105N0V mono-oxygenase ydhR GPY31_RS04755 ENOG4105D75 Capsular exopolysaccharide family GPY31_RS04765 ENOG4105DAY polysaccharide export protein GPY31_RS04775 ENOG41081FY multiple antibiotic resistance (MarC)-related GPY31_RS04780 ENOG4108NRW Phospholipase, patatin family GPY31_RS04785 ENOG4108M1A Chitin-binding protein GPY31_RS04790 ENOG4105C72 UPF0176 protein GPY31_RS04805 ENOG4105DZ1 carboxypeptidase GPY31_RS04815 ENOG4108ZX5 transcriptional regulator GPY31_RS04820 ENOG4108RCM Nitroreductase GPY31_RS04830 ENOG4105ETT transcriptional Regulator, LysR family GPY31_RS04835 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GPY31_RS04845 ENOG4105DP0 ferredoxin-NADP reductase GPY31_RS04855 ENOG41068P6 UPF0319 protein GPY31_RS04860 ENOG4105IPI Membrane GPY31_RS04900 ENOG4105G2Y Transcriptional regulator GPY31_RS04905 ENOG4105CNH Multidrug resistance protein MdtL GPY31_RS04915 ENOG4105I4A GCN5-related N-acetyltransferase GPY31_RS04925 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GPY31_RS04930 ENOG4105F1A Pyruvate formate-lyase GPY31_RS04935 ENOG4105C6N Formate acetyltransferase GPY31_RS04975 ENOG4105KWG Pfam:DUF1696 GPY31_RS04985 ENOG4105ER2 Ompa motb domain protein GPY31_RS04990 ENOG4107RD7 Flagellar Motor Protein, MotA GPY31_RS05015 ENOG4105MQ3 flagellar protein FliS GPY31_RS05020 ENOG410804A Flagellar hook-associated 2 domain-containing protein GPY31_RS05030 ENOG4105I03 Flagellin GPY31_RS05045 ENOG4105D00 flagellar biosynthetic protein flhB GPY31_RS05050 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GPY31_RS05055 ENOG4105VS8 Flagellar biosynthetic protein fliq GPY31_RS05060 ENOG4105CN7 Flagellar biosynthetic protein FliP GPY31_RS05065 ENOG4105DD5 Flagellar motor switch protein GPY31_RS05080 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS05090 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GPY31_RS05095 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY31_RS05105 ENOG4108JIR Flagellum-specific ATP synthase GPY31_RS05135 ENOG4107SSZ Phosphatase GPY31_RS05155 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GPY31_RS05160 ENOG4105EXG Transcriptional regulator GPY31_RS05190 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY31_RS05200 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GPY31_RS05210 ENOG4107R0W ABC transporter GPY31_RS05215 ENOG4105BZU Histidine kinase GPY31_RS05220 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPY31_RS05225 ENOG4105CPQ Dehydrogenase GPY31_RS05265 ENOG4105D64 Mechanosensitive ion channel GPY31_RS05275 ENOG4105DMF Dehydrogenase GPY31_RS05280 ENOG4105DAA L-lactate GPY31_RS05285 ENOG4105CR8 Transcriptional regulator GPY31_RS05295 ENOG4108JQ5 ABC transporter GPY31_RS05305 ENOG4105DAN ATP-dependent protease GPY31_RS05310 ENOG4108NVR Methyl-accepting chemotaxis GPY31_RS05315 ENOG4105YE1 PilZ domain GPY31_RS05335 ENOG4105WCN acetyltransferase GPY31_RS05340 ENOG4108BGM Quinol dehydrogenase periplasmic component GPY31_RS05345 ENOG4105GXZ Ferredoxin-type protein NapH GPY31_RS05360 ENOG4108JJB ABC transporter GPY31_RS05365 ENOG4108V7D UPF0397 protein GPY31_RS05370 ENOG4105EFX secretion protein, HlyD family GPY31_RS05375 ENOG4105KK7 inner membrane protein YiaW GPY31_RS05380 ENOG4106TD9 Diguanylate cyclase GPY31_RS05395 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GPY31_RS05405 ENOG4107SEY Conserved Protein GPY31_RS05410 ENOG4108XDN Transcriptional regulator GPY31_RS05415 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY31_RS05420 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GPY31_RS05430 ENOG4105C1J atp-dependent rna helicase GPY31_RS05435 ENOG4105CUG Oligopeptidase b GPY31_RS05440 ENOG4105D05 Receptor GPY31_RS05460 ENOG4108NVR Methyl-accepting chemotaxis GPY31_RS05465 ENOG4107S17 Phosphate-binding protein GPY31_RS05470 ENOG4105C8U phosphate abc transporter GPY31_RS05475 ENOG4105E2Z phosphate ABC transporter (Permease GPY31_RS05480 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS05515 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GPY31_RS05525 ENOG41069D7 Methyl-accepting chemotaxis GPY31_RS05535 ENOG41086KC Transcriptional regulator GPY31_RS05540 ENOG41086KC Transcriptional regulator GPY31_RS05550 ENOG4108JJ6 Type I secretion system ATPase GPY31_RS05570 ENOG4105UYK outer membrane protein a GPY31_RS05580 ENOG4105S6R Iron-hydroxamate transporter permease subunit GPY31_RS05585 ENOG4108HUF Transporter GPY31_RS05590 ENOG4105E0A ABC, transporter GPY31_RS05595 ENOG4105E0K tonB-dependent siderophore receptor GPY31_RS05600 ENOG4105BZ1 (ABC) transporter GPY31_RS05605 ENOG4105BZU Histidine kinase GPY31_RS05620 ENOG4105CZN Potassium uptake protein GPY31_RS05625 ENOG4105BZU Histidine kinase GPY31_RS05635 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GPY31_RS05645 ENOG4105EIP mannose-6-phosphate isomerase GPY31_RS05650 ENOG4105DM4 PTS System GPY31_RS05655 ENOG4106R3P AraC family transcriptional regulator GPY31_RS05665 ENOG4108YRF PTS System GPY31_RS05670 ENOG4105DM4 PTS System GPY31_RS05675 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPY31_RS05680 ENOG4105CH6 catalase GPY31_RS05685 ENOG4108RXX maleylacetoacetate isomerase GPY31_RS05690 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GPY31_RS05695 ENOG4108WUH Transcriptional regulator, TetR family GPY31_RS05700 ENOG4105V0I UPF0267 protein GPY31_RS05740 ENOG4105D75 Capsular exopolysaccharide family GPY31_RS05760 ENOG4108IJ9 (ABC) transporter GPY31_RS05765 ENOG4107FKK extracellular solute-binding protein family 1 GPY31_RS05770 ENOG4105D56 permease protein GPY31_RS05775 ENOG4105EG2 ABC transporter, permease GPY31_RS05795 ENOG4108P3C GPY31_RS05815 ENOG4105CHR reductase GPY31_RS05835 ENOG4105C4R Atp-dependent dna helicase GPY31_RS05840 ENOG4105NAE bifunctional deaminase-reductase domain protein GPY31_RS05850 ENOG4105CYM Glutathione S-transferase GPY31_RS05860 ENOG4105DZ1 carboxypeptidase GPY31_RS05880 ENOG4105EHV domain protein GPY31_RS05885 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GPY31_RS05900 ENOG4105VEQ Cold shock protein GPY31_RS05910 ENOG4108NRW Phospholipase, patatin family GPY31_RS05920 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GPY31_RS05945 ENOG4105EP9 oxidoreductase GPY31_RS05950 ENOG4105DIJ Phosphoethanolamine transferase GPY31_RS05955 ENOG41080IJ Diacylglycerol kinase GPY31_RS05965 ENOG4105JJR Histidine kinase GPY31_RS05970 ENOG4107EXC regulatoR GPY31_RS05975 ENOG4105EMU Dehydrogenase GPY31_RS05995 ENOG4108Z33 Thiol disulfide Interchange Protein GPY31_RS06015 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GPY31_RS06025 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) GPY31_RS06040 ENOG4105EST Metal Dependent Phosphohydrolase GPY31_RS06050 ENOG4105DZC cytosine deaminase GPY31_RS06055 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin GPY31_RS06065 ENOG4105CJW magnesium transporter GPY31_RS06070 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GPY31_RS06085 ENOG4105DVH amino acid GPY31_RS06095 ENOG4108XM1 transcriptional regulator AsnC family GPY31_RS06100 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GPY31_RS06120 ENOG4105BZU Histidine kinase GPY31_RS06125 ENOG4105EE0 oxidoreductase GPY31_RS06135 ENOG41090HJ UPF0265 protein GPY31_RS06150 ENOG4108YXG UPF0502 protein GPY31_RS06155 ENOG41082IR Excinuclease ABC C subunit domain protein GPY31_RS06160 ENOG4108QGH periplasmic GPY31_RS06165 ENOG4105BZU Histidine kinase GPY31_RS06175 ENOG4105EFX secretion protein, HlyD family GPY31_RS06195 ENOG4105EW9 transcriptional regulator AsnC family GPY31_RS06220 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY31_RS06225 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY31_RS06245 ENOG4105CHU acetyl-coa acetyltransferase GPY31_RS06255 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class GPY31_RS06265 ENOG4105CUW cytochrome C-TYPE protein GPY31_RS06275 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GPY31_RS06290 ENOG4105BZU Histidine kinase GPY31_RS06295 ENOG4105WH1 Two component transcriptional regulator luxr family GPY31_RS06310 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GPY31_RS06315 ENOG4107YWA deoxycytidylate deaminase GPY31_RS06330 ENOG4108N3W hemolysin secretion protein GPY31_RS06335 ENOG4108YZN class I peptide chain release factor GPY31_RS06340 ENOG4107VXZ Hydrolase GPY31_RS06345 ENOG4105UYK outer membrane protein a GPY31_RS06350 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY31_RS06355 ENOG4105DXI Major Facilitator superfamily GPY31_RS06365 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GPY31_RS06370 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPY31_RS06375 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GPY31_RS06395 ENOG4105BZU Histidine kinase GPY31_RS06400 ENOG4105KHC sulfurtransferase GPY31_RS06420 ENOG4105D06 uba thif-type nad fad binding protein GPY31_RS06425 ENOG4105CVM Molybdenum cofactor synthesis domain protein GPY31_RS06435 ENOG4105C5A transporter GPY31_RS06445 ENOG4105CMQ Chloride channel GPY31_RS06460 ENOG4107RGM aldo keto reductase GPY31_RS06465 ENOG4108UNF response regulator GPY31_RS06475 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GPY31_RS06480 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY31_RS06485 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY31_RS06490 ENOG4105C10 Electron transfer flavoprotein GPY31_RS06495 ENOG4105BZJ Electron transfer flavoprotein GPY31_RS06500 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GPY31_RS06505 ENOG4105C0Z ABC transporter GPY31_RS06530 ENOG4108IV0 ABC, transporter GPY31_RS06535 ENOG4105DZS Phenylacetate-CoA ligase GPY31_RS06550 ENOG4105G9V cytochrome C GPY31_RS06560 ENOG4105VUF Transcriptional regulator GPY31_RS06565 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GPY31_RS06570 ENOG4108S58 Phenazine biosynthesis protein PhzF GPY31_RS06580 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY31_RS06585 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY31_RS06590 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY31_RS06595 ENOG4108UW5 maltose o-acetyltransferase GPY31_RS06605 ENOG4105EGS Mechanosensitive ion channel GPY31_RS06620 ENOG4105BZU Histidine kinase GPY31_RS06625 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GPY31_RS06635 ENOG4108UKI Enoyl-CoA hydratase GPY31_RS06640 ENOG4107QX3 carboxylase GPY31_RS06645 ENOG4105C1G acyl-Coa dehydrogenase GPY31_RS06655 ENOG4105CHU acetyl-coa acetyltransferase GPY31_RS06660 ENOG4105C26 Dehydrogenase GPY31_RS06665 ENOG4105C1G acyl-Coa dehydrogenase GPY31_RS06670 ENOG4105E39 Enoyl-CoA hydratase GPY31_RS06680 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPY31_RS06695 ENOG4105BZU Histidine kinase GPY31_RS06700 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GPY31_RS06705 ENOG4105C26 Dehydrogenase GPY31_RS06710 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GPY31_RS06720 ENOG4108HQS Glycine betaine GPY31_RS06725 ENOG4108IJ7 Glycine betaine GPY31_RS06730 ENOG4108RCM Nitroreductase GPY31_RS06740 ENOG4107QX8 SPFH domain, Band 7 family protein GPY31_RS06750 ENOG4105BZU Histidine kinase GPY31_RS06765 ENOG4105CA0 peroxidase GPY31_RS06770 ENOG4105BZU Histidine kinase GPY31_RS06795 ENOG4107R08 Integrase GPY31_RS06835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY31_RS06840 ENOG4105GR3 Histidine kinase GPY31_RS06845 ENOG4105EJC lysr family transcriptional regulator GPY31_RS06850 ENOG4105DAA L-lactate GPY31_RS06855 ENOG4105CXG d-lactate dehydrogenase GPY31_RS06875 ENOG4105BZU Histidine kinase GPY31_RS06955 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GPY31_RS06960 ENOG4108K0B C-di-gmp phosphodiesterase GPY31_RS06965 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GPY31_RS06970 ENOG4105C2J ABC transporter GPY31_RS06975 ENOG4105CNN ABC, transporter GPY31_RS06980 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GPY31_RS06985 ENOG4108RVA ribokinase GPY31_RS06990 ENOG4105ETE Transcriptional regulator (LacI family GPY31_RS07000 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GPY31_RS07005 ENOG4108I5U Uridine phosphorylase GPY31_RS07020 ENOG4105ETX regulatoR GPY31_RS07035 ENOG4105G6Z alkaline phosphatase GPY31_RS07055 ENOG4105BZU Histidine kinase GPY31_RS07065 ENOG4105C44 Serine transporter GPY31_RS07070 ENOG4108R6G acetyltransferase GPY31_RS07080 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPY31_RS07115 ENOG4105DG7 nitrate ABC transporter GPY31_RS07120 ENOG4105D7T ABC transporter GPY31_RS07125 ENOG4107QZF nitrite reductase NADPH large subunit GPY31_RS07140 ENOG4108IG5 Transcriptional regulator GPY31_RS07155 ENOG4105F8J Adenylate Guanylate cyclase GPY31_RS07180 ENOG4105D9P serine threonine protein kinase GPY31_RS07200 ENOG4106VK6 Flagellar motor protein GPY31_RS07215 ENOG4108ZF3 Phosphatase GPY31_RS07260 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY31_RS07285 ENOG4107RFY SbcCD D subunit GPY31_RS07290 ENOG4105EYH Exonuclease GPY31_RS07310 ENOG4105QNF Outer membrane lipoprotein GPY31_RS07320 ENOG4105C2C drug resistance transporter, Bcr CflA GPY31_RS07330 ENOG4105CSX c4-dicarboxylate anaerobic carrier GPY31_RS07345 ENOG4105C5W Aldolase GPY31_RS07355 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) GPY31_RS07360 ENOG4105EV2 VWA domain protein interacting with AAA ATPase GPY31_RS07380 ENOG4105CC0 LysR family Transcriptional regulator GPY31_RS07385 ENOG4105CXG d-lactate dehydrogenase GPY31_RS07405 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY31_RS07410 ENOG4108NVR Methyl-accepting chemotaxis GPY31_RS07445 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GPY31_RS07485 ENOG4105NXH GreA GreB family elongation factor GPY31_RS07490 ENOG4107QZF nitrite reductase NADPH large subunit GPY31_RS07495 ENOG4105WZK nitrite reductase NADPH small subunit GPY31_RS07500 ENOG4105TMB Formate nitrite transporter GPY31_RS07505 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPY31_RS07520 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPY31_RS07545 ENOG4105VXR cytoplasmic protein GPY31_RS07550 ENOG4107QI1 Mate efflux family protein GPY31_RS07560 ENOG4108ISG Major Facilitator GPY31_RS07565 ENOG4105K63 Thioredoxin GPY31_RS07570 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GPY31_RS07590 ENOG4105EIP mannose-6-phosphate isomerase GPY31_RS07595 ENOG4105CXY transporter GPY31_RS07600 ENOG4105BZU Histidine kinase GPY31_RS07605 ENOG4108KX4 response regulator GPY31_RS07610 ENOG4105CXY transporter GPY31_RS07615 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GPY31_RS07620 ENOG4105C5Q Transcriptional regulator GPY31_RS07630 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit GPY31_RS07660 ENOG4105BZS acriflavin resistance protein GPY31_RS07675 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GPY31_RS07680 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GPY31_RS07685 ENOG4107QI1 Mate efflux family protein GPY31_RS07695 ENOG4105ECQ AraC Family Transcriptional Regulator GPY31_RS07700 ENOG4105CGF Aromatic amino acid aminotransferase GPY31_RS07705 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY31_RS07715 ENOG4105WXI Bacterial OB fold (BOF) protein GPY31_RS07720 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GPY31_RS07725 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GPY31_RS07730 ENOG4105E0C molybdate abc transporter GPY31_RS07735 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS07755 ENOG4105BZU Histidine kinase GPY31_RS07770 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPY31_RS07775 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPY31_RS07805 ENOG4108M6U Universal stress protein A GPY31_RS07815 ENOG4105EJC lysr family transcriptional regulator GPY31_RS07835 ENOG4108ZJT translation initiation factor, Sui1 GPY31_RS07845 ENOG4105CPF Cell wall formation (By similarity) GPY31_RS07855 ENOG4105CD5 CoA-binding domain protein GPY31_RS07860 ENOG4105CWB LysR family transcriptional Regulator GPY31_RS07875 ENOG4105CMR udp-glucose 4-epimerase GPY31_RS07880 ENOG4105BZU Histidine kinase GPY31_RS07885 ENOG4105E7W lamb ycsf family protein GPY31_RS07890 ENOG4105P4J Allophanate hydrolase, subunit 1 GPY31_RS07895 ENOG4107R7A Allophanate hydrolase subunit 2 GPY31_RS07905 ENOG4105CV6 ABC transporter, permease GPY31_RS07910 ENOG4108I0Y (ABC) transporter GPY31_RS07920 ENOG4105RKW reductase (By GPY31_RS07925 ENOG4105BZU Histidine kinase GPY31_RS07935 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GPY31_RS07960 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GPY31_RS07970 ENOG4105KA0 thioesterase Superfamily protein GPY31_RS07985 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY31_RS07990 ENOG4108M0H Extracellular lipase GPY31_RS08005 ENOG4105DU1 integral membrane protein, terc GPY31_RS08010 ENOG4105CGH 5'-nucleotidase GPY31_RS08015 ENOG4105CPB ATP-dependent endonuclease of the OLD family GPY31_RS08020 ENOG4108UQ5 membrane protein YcdZ GPY31_RS08025 ENOG4105DUM transcriptional regulator, lysR family GPY31_RS08030 ENOG4105TMB Formate nitrite transporter GPY31_RS08035 ENOG4108YYC ycei family GPY31_RS08040 ENOG4105DS1 cytochrome b561 GPY31_RS08055 ENOG4108M8H domain protein GPY31_RS08060 ENOG4105C1J atp-dependent rna helicase GPY31_RS08065 ENOG4108ZYK Acyl carrier protein phosphodiesterase GPY31_RS08080 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPY31_RS08090 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY31_RS08110 ENOG4107RE1 Inosine-guanosine kinase GPY31_RS08115 ENOG4105CKU formyltetrahydrofolate synthetase GPY31_RS08120 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GPY31_RS08135 ENOG4105CF7 AraC family transcriptional regulator GPY31_RS08140 ENOG4108I6A alcohol dehydrogenase GPY31_RS08150 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta GPY31_RS08160 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC GPY31_RS08165 ENOG4105CXY transporter GPY31_RS08170 ENOG4105CA9 Pyruvate kinase GPY31_RS08175 ENOG4105CDA abc transporter atp-binding protein GPY31_RS08180 ENOG4105E5Q amino acid AbC transporter GPY31_RS08185 ENOG4106TNF Periplasmic binding protein GPY31_RS08190 ENOG4105DRP amino acid AbC transporter GPY31_RS08195 ENOG4108NJZ Sensory box GGDEF EAL domain protein GPY31_RS08215 ENOG4107B7Y DNA-binding transcriptional regulator FruR GPY31_RS08220 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GPY31_RS08225 ENOG4105DE4 1-phosphofructokinase GPY31_RS08230 ENOG4105DM4 PTS System GPY31_RS08270 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GPY31_RS08275 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GPY31_RS08280 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GPY31_RS08305 ENOG4105EQR Transposase IS116 IS110 IS902 GPY31_RS08315 ENOG4105KVH Transcriptional regulator GPY31_RS08360 ENOG4105CR8 Transcriptional regulator GPY31_RS08365 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GPY31_RS08395 ENOG4105HDD phospholipase GPY31_RS08415 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GPY31_RS08445 ENOG4105CJW magnesium transporter GPY31_RS08465 ENOG4108UYE Lactoylglutathione lyase GPY31_RS08470 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY31_RS08495 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GPY31_RS08505 ENOG4105CBC glutamate synthase GPY31_RS08515 ENOG4106YYS transcriptional regulatory protein GPY31_RS08520 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPY31_RS08525 ENOG4107QPK )-transporter GPY31_RS08530 ENOG4107RGH Aldehyde dehydrogenase GPY31_RS08550 ENOG4108I0N Transporter, RarD family, DMT superfamily protein GPY31_RS08570 ENOG4106CKV Pap2 superfamily protein GPY31_RS08585 ENOG4105FR1 rard protein GPY31_RS08655 ENOG4105BZU Histidine kinase GPY31_RS08660 ENOG4105C5H ABC transporter GPY31_RS08665 ENOG4107XZQ multidrug resistance protein GPY31_RS08675 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GPY31_RS08735 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GPY31_RS08740 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPY31_RS08745 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GPY31_RS08755 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GPY31_RS08760 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GPY31_RS08765 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GPY31_RS08770 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY31_RS08785 ENOG4105D8G Major Facilitator superfamily GPY31_RS08790 ENOG4105BZU Histidine kinase GPY31_RS08795 ENOG4105C9Q fumarate hydratase class II GPY31_RS08815 ENOG4107QN1 sodium solute GPY31_RS08825 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GPY31_RS08835 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GPY31_RS08840 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPY31_RS08845 ENOG4108IJ0 Aspartate ammonia-lyase GPY31_RS08850 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GPY31_RS08855 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GPY31_RS08865 ENOG4105E0F Histidine kinase GPY31_RS08870 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY31_RS08875 ENOG4108SPG Periplasmic Protein GPY31_RS08880 ENOG41076HS cation diffusion facilitator family transporter GPY31_RS08885 ENOG4105CTQ phosphohexokinase GPY31_RS08890 ENOG4107QI1 Mate efflux family protein GPY31_RS08895 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GPY31_RS08900 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPY31_RS08915 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY31_RS08925 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GPY31_RS08930 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GPY31_RS08940 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPY31_RS08945 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPY31_RS08950 ENOG4105E33 succinate dehydrogenase GPY31_RS08965 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) GPY31_RS08975 ENOG41062JF Transcriptional regulator GPY31_RS08985 ENOG41063SB peptidase GPY31_RS08990 ENOG4105D7W serine acetyltransferase GPY31_RS08995 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GPY31_RS09000 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GPY31_RS09005 ENOG4107YZP Rhodanese domain protein GPY31_RS09010 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GPY31_RS09020 ENOG4108NVR Methyl-accepting chemotaxis GPY31_RS09025 ENOG4105C8P )-transporter GPY31_RS09030 ENOG4105DJ4 phosphatidylserine decarboxylase GPY31_RS09035 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GPY31_RS09040 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GPY31_RS09120 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GPY31_RS09125 ENOG4105K8N protein family UPF0079, ATPase GPY31_RS09130 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GPY31_RS09135 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GPY31_RS09140 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GPY31_RS09145 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GPY31_RS09150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GPY31_RS09155 ENOG4107QJR hflk protein GPY31_RS09160 ENOG4105EPW hflc protein GPY31_RS09170 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GPY31_RS09180 ENOG4108UV7 flagellar protein motX GPY31_RS09185 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GPY31_RS09190 ENOG4105KPV Transcriptional regulator GPY31_RS09195 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GPY31_RS09200 ENOG4105C2N RNA methyltransferase TrmH family group 3 GPY31_RS09205 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPY31_RS09210 ENOG4105C31 Tryptophanyl-tRNA synthetase GPY31_RS09240 ENOG4105DDQ anthranilate synthase GPY31_RS09245 ENOG4105C8Y Acetylornithine aminotransferase GPY31_RS09255 ENOG4105C26 Dehydrogenase GPY31_RS09265 ENOG4107RYR Transcriptional regulator, Crp Fnr family GPY31_RS09270 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GPY31_RS09275 ENOG4105YP7 UPF0270 protein GPY31_RS09280 ENOG4105DNZ Alpha Beta Hydrolase GPY31_RS09290 ENOG4105C5H ABC transporter GPY31_RS09300 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GPY31_RS09315 ENOG4108YZY peptidylprolyl cis-trans isomerase GPY31_RS09325 ENOG4105D44 asparaginase GPY31_RS09330 ENOG41069P5 Protein slyX homolog GPY31_RS09340 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY31_RS09345 ENOG4105WWK YheO domain protein GPY31_RS09350 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) GPY31_RS09355 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GPY31_RS09360 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GPY31_RS09365 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GPY31_RS09370 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GPY31_RS09375 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPY31_RS09380 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GPY31_RS09385 ENOG4105W53 bacterioferritin-associated ferredoxin GPY31_RS09390 ENOG4108UQY Iron-storage protein GPY31_RS09395 ENOG4105C6K Malic enzyme GPY31_RS09400 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) GPY31_RS09405 ENOG4105C28 cystathionine GPY31_RS09410 ENOG4105CFH Aspartokinase GPY31_RS09415 ENOG4105SYT Methylenetetrahydrofolate reductase GPY31_RS09425 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GPY31_RS09430 ENOG4105CWC Acetylornithine deacetylase GPY31_RS09435 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GPY31_RS09440 ENOG4105CAS nag kinase GPY31_RS09445 ENOG4105CDH Citrulline--aspartate ligase GPY31_RS09450 ENOG4105CH7 arginosuccinase GPY31_RS09465 ENOG4105EHV domain protein GPY31_RS09475 ENOG4108JQC penicillin-binding protein 1A GPY31_RS09500 ENOG4105E4G Type IV pilus GPY31_RS09505 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GPY31_RS09510 ENOG4105D49 3-dehydroquinate synthase GPY31_RS09520 ENOG4105DFE Dna adenine methylase GPY31_RS09525 ENOG4105DJV ribulose-phosphate 3-epimerase GPY31_RS09530 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GPY31_RS09535 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) GPY31_RS09540 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GPY31_RS09545 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GPY31_RS09555 ENOG4105CDU Replicative dna helicase GPY31_RS09560 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY31_RS09570 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GPY31_RS09575 ENOG4107QP8 phosphohexose isomerase GPY31_RS09585 ENOG4105MYN Zinc uptake regulation protein GPY31_RS09595 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPY31_RS09620 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GPY31_RS09625 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GPY31_RS09630 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GPY31_RS09705 ENOG4105EEQ Na H antiporter GPY31_RS09710 ENOG4105C3R Methionine synthase GPY31_RS09715 ENOG4105CFH Aspartokinase GPY31_RS09720 ENOG4105C5R Aminotransferase GPY31_RS09730 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GPY31_RS09735 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GPY31_RS09740 ENOG41086KC Transcriptional regulator GPY31_RS09745 ENOG4108UUM single-stranded DNA-binding protein GPY31_RS09750 ENOG41062P1 Diguanylate cyclase phosphodiesterase GPY31_RS09770 ENOG4105E4G Type IV pilus GPY31_RS09785 ENOG4107QHF type ii secretion system protein e GPY31_RS09790 ENOG4105D7Q type ii secretion system GPY31_RS09835 ENOG4105DFF Rod shape-determining protein mreb GPY31_RS09840 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GPY31_RS09845 ENOG4105VQ7 Rod shape-determining protein MreD GPY31_RS09850 ENOG4108Z03 MAF-like protein GPY31_RS09855 ENOG4105C03 ribonuclease GPY31_RS09870 ENOG4105D1U peptidase U62 modulator of DNA gyrase GPY31_RS09875 ENOG4108IAB Phoh family GPY31_RS09880 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GPY31_RS09885 ENOG4105K3M )-transporter GPY31_RS09895 ENOG4105D3G Pseudouridine synthase GPY31_RS09900 ENOG4105C5I Dehydrogenase GPY31_RS09905 ENOG4105N42 UPF0307 protein GPY31_RS09910 ENOG4105CMS peptidase U62, modulator of DNA gyrase GPY31_RS09915 ENOG4105CJW magnesium transporter GPY31_RS09920 ENOG41080Z8 PHOSPHOCARRIER protein GPY31_RS09925 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GPY31_RS09930 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GPY31_RS09935 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GPY31_RS09940 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY31_RS09945 ENOG4108IUZ ABC transporter GPY31_RS09950 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GPY31_RS09960 ENOG4105C2X Arabinose 5-phosphate isomerase GPY31_RS09970 ENOG4105DHJ ABC, transporter GPY31_RS09975 ENOG4105CY3 ABC transporter, permease GPY31_RS09980 ENOG4107PE3 Mammalian cell entry related domain protein GPY31_RS09985 ENOG4105E3I toluene tolerance GPY31_RS09995 ENOG4105VFK BolA family GPY31_RS10000 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GPY31_RS10005 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GPY31_RS10010 ENOG4105KME endoribonuclease L-psp GPY31_RS10015 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GPY31_RS10020 ENOG4105CXT aspartate transcarbamylase GPY31_RS10030 ENOG4105DBV ornithine carbamoyltransferase GPY31_RS10035 ENOG4105CEU Arginine dihydrolase GPY31_RS10055 ENOG4108MJ3 acetyltransferase GPY31_RS10065 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GPY31_RS10070 ENOG4105MYG DNA polymerase iii, chi subunit GPY31_RS10075 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPY31_RS10080 ENOG4108M8S permease YjgP YjgQ family protein GPY31_RS10085 ENOG4108K5H permease YjgP YjgQ family protein GPY31_RS10095 ENOG4105EXU Membrane GPY31_RS10100 ENOG4107JEE Short-chain dehydrogenase reductase Sdr GPY31_RS10115 ENOG4105VZJ PTS System GPY31_RS10120 ENOG4105CK1 PTS System GPY31_RS10125 ENOG4105VCP PTS System GPY31_RS10130 ENOG4105F8D glycoside hydrolase family 4 GPY31_RS10135 ENOG410901P UPF0249 protein GPY31_RS10145 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY31_RS10195 ENOG4105C26 Dehydrogenase GPY31_RS10225 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS10265 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division GPY31_RS10270 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GPY31_RS10275 ENOG4105CEN a g-specific adenine glycosylase GPY31_RS10280 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GPY31_RS10290 ENOG4105CSV Glutaminase GPY31_RS10295 ENOG4105CSA Coproporphyrinogen iii oxidase GPY31_RS10300 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GPY31_RS10310 ENOG4105VZ9 UPF0235 protein GPY31_RS10315 ENOG4108VIA integral membrane protein GPY31_RS10320 ENOG4105II7 pyrroline-5-carboxylate reductase GPY31_RS10325 ENOG4105DFA alanine racemase domain protein GPY31_RS10330 ENOG4105CZX twitching motility protein GPY31_RS10335 ENOG4105CZX twitching motility protein GPY31_RS10340 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GPY31_RS10345 ENOG4108UJU UPF0301 protein GPY31_RS10350 ENOG4105D7Z glutathione synthase GPY31_RS10355 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GPY31_RS10360 ENOG4105RWS endonuclease I GPY31_RS10365 ENOG4105GPY SprT protein GPY31_RS10375 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GPY31_RS10385 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPY31_RS10390 ENOG4108R4R Iron-regulated virulence regulatory protein GPY31_RS10395 ENOG4105D05 Receptor GPY31_RS10400 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY31_RS10405 ENOG4105BZA Phosphoglycerate kinase GPY31_RS10410 ENOG4105D2N Aldolase GPY31_RS10415 ENOG4105D64 Mechanosensitive ion channel GPY31_RS10420 ENOG4108KXH Ybak prolyl-tRNA synthetase associated GPY31_RS10430 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GPY31_RS10435 ENOG4105MPN Membrane GPY31_RS10440 ENOG4108JQ1 Dehydrogenase GPY31_RS10445 ENOG4105E66 phosphoriboisomerase A GPY31_RS10450 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GPY31_RS10460 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GPY31_RS10475 ENOG4105D0A hydroxylase GPY31_RS10480 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPY31_RS10495 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) GPY31_RS10500 ENOG4105Y75 tpr repeat protein GPY31_RS10510 ENOG4108IYU L-aspartate oxidase GPY31_RS10525 ENOG41069PW sigma-e factor negative regulatory protein GPY31_RS10540 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GPY31_RS10545 ENOG4105C3F Signal peptidase i GPY31_RS10550 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GPY31_RS10555 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GPY31_RS10560 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) GPY31_RS10565 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GPY31_RS10570 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GPY31_RS10575 ENOG4105BZU Histidine kinase GPY31_RS10580 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GPY31_RS10590 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPY31_RS10595 ENOG4105DXN mazG family GPY31_RS10600 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GPY31_RS10605 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GPY31_RS10610 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GPY31_RS10615 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GPY31_RS10620 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GPY31_RS10625 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) GPY31_RS10630 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GPY31_RS10635 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GPY31_RS10650 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GPY31_RS10655 ENOG4107TH8 cina domain protein GPY31_RS10660 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GPY31_RS10665 ENOG4105Y3E Modulates RecA activity (By similarity) GPY31_RS10670 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GPY31_RS10675 ENOG4105CFH Aspartokinase GPY31_RS10680 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GPY31_RS10735 ENOG4106AFN Lyase and sodium transporter (By similarity) GPY31_RS10740 ENOG4107QSA Oxaloacetate decarboxylase GPY31_RS10745 ENOG4105D9Q decarboxylase (Beta subunit) GPY31_RS10750 ENOG4105CPQ Dehydrogenase GPY31_RS10755 ENOG4105W39 Membrane GPY31_RS10765 ENOG4105D9M gamma-glutamylcysteine synthetase GPY31_RS10775 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GPY31_RS10780 ENOG4108JU6 CBS domain protein GPY31_RS10785 ENOG4106KVJ cytochrome C assembly protein GPY31_RS10790 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GPY31_RS10795 ENOG4105K5M 30s ribosomal protein S16 GPY31_RS10800 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GPY31_RS10805 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GPY31_RS10810 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GPY31_RS10815 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) GPY31_RS10820 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GPY31_RS10825 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GPY31_RS10830 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) GPY31_RS10835 ENOG4105D7Q type ii secretion system GPY31_RS10840 ENOG4107QHF type ii secretion system protein e GPY31_RS10850 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GPY31_RS10860 ENOG41073TP transcriptional regulator GPY31_RS10865 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GPY31_RS10870 ENOG4107QSN dihydrolipoamide acetyltransferase GPY31_RS10875 ENOG4107QN2 dihydrolipoyl dehydrogenase GPY31_RS10880 ENOG410630P Transcriptional regulator GPY31_RS10885 ENOG4108UGV hypoxanthine phosphoribosyltransferase GPY31_RS10890 ENOG41077A9 carbonic anhydrase GPY31_RS10895 ENOG4105CHH sulfate transporter GPY31_RS10905 ENOG4105DA5 (ABC) transporter GPY31_RS10910 ENOG4105E3A (ABC) transporter GPY31_RS10915 ENOG4105D1S lipid A biosynthesis GPY31_RS10925 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GPY31_RS10930 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GPY31_RS10935 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPY31_RS10940 ENOG4105DJ0 Poly(A) Polymerase GPY31_RS10950 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GPY31_RS10960 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GPY31_RS10965 ENOG4105PW4 Sugar fermentation stimulation protein homolog GPY31_RS10970 ENOG4105CQ7 ATP-dependent helicase GPY31_RS10975 ENOG4105BZ4 penicillin-binding protein GPY31_RS10980 ENOG4105D78 K07001 NTE family protein GPY31_RS10985 ENOG4107QIJ Aconitate hydratase 2 GPY31_RS10990 ENOG4105XTV UPF0231 protein GPY31_RS10995 ENOG4108YZA Nitrogen regulatory protein pii GPY31_RS11015 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS11020 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GPY31_RS11030 ENOG4105E2D ec 3.2.1.52 GPY31_RS11035 ENOG4105RD7 BadF BadG BcrA BcrD GPY31_RS11045 ENOG4108JQ7 (ABC) transporter GPY31_RS11050 ENOG4105C3U ABC transporter GPY31_RS11055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY31_RS11065 ENOG4107QRA Extracellular solute-binding protein, family 5 GPY31_RS11070 ENOG4105BZU Histidine kinase GPY31_RS11075 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GPY31_RS11080 ENOG4105IPI Membrane GPY31_RS11085 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GPY31_RS11090 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GPY31_RS11100 ENOG4105BZS acriflavin resistance protein GPY31_RS11105 ENOG4105DR5 peptidase GPY31_RS11110 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GPY31_RS11120 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GPY31_RS11125 ENOG4107QE9 Inherit from COG: Membrane GPY31_RS11130 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GPY31_RS11135 ENOG4105HBR Rna-binding protein GPY31_RS11140 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) GPY31_RS11145 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GPY31_RS11150 ENOG4105EEI dihydropteroate synthase GPY31_RS11155 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GPY31_RS11180 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GPY31_RS11185 ENOG4105CHV Transcription elongation factor NusA GPY31_RS11190 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GPY31_RS11195 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GPY31_RS11200 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GPY31_RS11205 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GPY31_RS11210 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GPY31_RS11225 ENOG4105C3S Mate efflux family protein GPY31_RS11230 ENOG4106RZ4 Peptidase U32 GPY31_RS11235 ENOG4105CFP Peptidase U32 GPY31_RS11240 ENOG4105BZU Histidine kinase GPY31_RS11245 ENOG4105XPQ lipid carrier protein GPY31_RS11250 ENOG4108YYD acetyltransferase GPY31_RS11260 ENOG4108WPU DNA polymerase III subunit psi GPY31_RS11270 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GPY31_RS11280 ENOG4105EYA deoxyribonuclease GPY31_RS11285 ENOG4105D9N nucleoside GPY31_RS11290 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GPY31_RS11295 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GPY31_RS11300 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GPY31_RS11305 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GPY31_RS11315 ENOG4105EAC phosphoserine phosphatase GPY31_RS11325 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GPY31_RS11330 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPY31_RS11335 ENOG4105ETT transcriptional Regulator, LysR family GPY31_RS11345 ENOG4108IQE Amp-dependent synthetase and ligase GPY31_RS11435 ENOG41064T2 transcriptional regulator, lysR family GPY31_RS11440 ENOG4105E5D amino acid GPY31_RS11445 ENOG4105FK9 beta-D-galactosidase beta subunit GPY31_RS11450 ENOG4105CNT hydrolase family 2 GPY31_RS11455 ENOG4105CQ4 Transcriptional regulator GPY31_RS11465 ENOG4105CMR udp-glucose 4-epimerase GPY31_RS11470 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GPY31_RS11475 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GPY31_RS11480 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GPY31_RS11485 ENOG4105ETE Transcriptional regulator (LacI family GPY31_RS11495 ENOG4105CT4 transporter GPY31_RS11500 ENOG41060NJ transcriptional regulator GPY31_RS11505 ENOG4108Y51 tRNA-binding protein GPY31_RS11520 ENOG4107RX3 Mg2 transporter protein cora family protein GPY31_RS11525 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GPY31_RS11530 ENOG4105E98 transcriptional regulator DeoR family GPY31_RS11535 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GPY31_RS11540 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GPY31_RS11555 ENOG4105CXY transporter GPY31_RS11560 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GPY31_RS11565 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GPY31_RS11570 ENOG4105X2V dna damage-inducible protein GPY31_RS11575 ENOG4105EVZ LysR family transcriptional regulator GPY31_RS11585 ENOG4105E68 Sulfatase GPY31_RS11590 ENOG4105DSY exodeoxyribonuclease V, gamma GPY31_RS11595 ENOG4107QKA exodeoxyribonuclease V beta GPY31_RS11600 ENOG4107QYX exodeoxyribonuclease v alpha GPY31_RS11610 ENOG4107QZM n-acetylglutamate synthase GPY31_RS11620 ENOG4105CA3 membrane-bound lytic murein transglycosylase GPY31_RS11625 ENOG4105CUZ uba thif-type nad fad binding protein GPY31_RS11630 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GPY31_RS11635 ENOG4105BZU Histidine kinase GPY31_RS11640 ENOG4105C9B Cysteine desulfurase GPY31_RS11645 ENOG4107S0N DJ-1 family GPY31_RS11650 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GPY31_RS11675 ENOG4105K6V RNA polymerase GPY31_RS11690 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY31_RS11695 ENOG4105IEY (LipO)protein GPY31_RS11700 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GPY31_RS11705 ENOG4105M85 Bola protein GPY31_RS11710 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY31_RS11715 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY31_RS11720 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY31_RS11725 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY31_RS11730 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY31_RS11735 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) GPY31_RS11740 ENOG4105CJ2 (LipO)protein GPY31_RS11780 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GPY31_RS11785 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY31_RS11810 ENOG4105EJC lysr family transcriptional regulator GPY31_RS11845 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GPY31_RS11850 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GPY31_RS11855 ENOG4105C9U ATP-dependent DNA helicase RecQ GPY31_RS11860 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GPY31_RS11875 ENOG4105C8J )-transporter GPY31_RS11885 ENOG4105W1I UPF0253 protein GPY31_RS11895 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GPY31_RS11900 ENOG4108R96 Methyltransferase, YaeB family GPY31_RS11905 ENOG4105NRA 50s ribosomal protein l31 type b GPY31_RS11920 ENOG4105CFC Transporter GPY31_RS11925 ENOG4108UPT UPF0178 protein GPY31_RS11950 ENOG4105WP7 tRNA pseudouridine synthase C GPY31_RS11955 ENOG4105DR9 pseudouridine synthase GPY31_RS11960 ENOG4108T8E UPF0325 protein GPY31_RS11965 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GPY31_RS11970 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GPY31_RS11975 ENOG4105CE9 30S ribosomal protein S2 GPY31_RS11980 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GPY31_RS11985 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GPY31_RS11990 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GPY31_RS11995 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GPY31_RS12000 ENOG4105KNE Phosphatidate cytidylyltransferase GPY31_RS12005 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GPY31_RS12010 ENOG4105DZP Membrane-associated zinc metalloprotease GPY31_RS12020 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GPY31_RS12025 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY31_RS12030 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GPY31_RS12035 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY31_RS12040 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY31_RS12045 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY31_RS12050 ENOG4105C0B DNA polymerase III (alpha subunit) GPY31_RS12055 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GPY31_RS12060 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GPY31_RS12070 ENOG4108YZA Nitrogen regulatory protein pii GPY31_RS12075 ENOG4107NA1 Endonuclease Exonuclease phosphatase GPY31_RS12085 ENOG4105E9H Lytic Murein transglycosylase GPY31_RS12090 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GPY31_RS12095 ENOG4105D1A Methyltransferase GPY31_RS12100 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY31_RS12105 ENOG4107RZZ dna polymerase iii epsilon subunit GPY31_RS12120 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GPY31_RS12130 ENOG4107QPN acyl-Coa dehydrogenase GPY31_RS12135 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GPY31_RS12140 ENOG4105E7A Glutamine amidotransferase GPY31_RS12145 ENOG4108V3E phosphoribosylglycinamide formyltransferase GPY31_RS12150 ENOG4105CXB phosphoribosylaminoimidazole synthetase GPY31_RS12155 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GPY31_RS12160 ENOG4105C2W permease GPY31_RS12180 ENOG4105ERG peptidase m48, ste24p GPY31_RS12195 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GPY31_RS12200 ENOG4105RH4 Glycine cleavage system transcriptional repressor GPY31_RS12210 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY31_RS12225 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GPY31_RS12230 ENOG4105KUZ arsenate reductase GPY31_RS12255 ENOG4105QZU Inner membrane protein YfeZ GPY31_RS12260 ENOG4105EZR dyp-type peroxidase family protein GPY31_RS12265 ENOG4105I03 Flagellin GPY31_RS12275 ENOG4105I03 Flagellin GPY31_RS12280 ENOG4105I03 Flagellin GPY31_RS12285 ENOG41063QE flagellar protein FlaG GPY31_RS12290 ENOG4107BRV flagellar capping protein GPY31_RS12300 ENOG4105MQ3 flagellar protein FliS GPY31_RS12305 ENOG4108JUA Transcriptional regulator GPY31_RS12310 ENOG4105BZU Histidine kinase GPY31_RS12315 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS12320 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GPY31_RS12325 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GPY31_RS12330 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY31_RS12340 ENOG4108JIR Flagellum-specific ATP synthase GPY31_RS12360 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY31_RS12365 ENOG4105DD5 Flagellar motor switch protein GPY31_RS12370 ENOG4105VTB flagellar biosynthesis protein fliO GPY31_RS12375 ENOG4105CN7 Flagellar biosynthetic protein FliP GPY31_RS12380 ENOG4105VS8 Flagellar biosynthetic protein fliq GPY31_RS12385 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GPY31_RS12390 ENOG4105D00 flagellar biosynthetic protein flhB GPY31_RS12395 ENOG4105D7B Flagellar biosynthesis protein flha GPY31_RS12400 ENOG4105FZW flagellar biosynthesis regulator FlhF GPY31_RS12405 ENOG4107R21 site-determining protein GPY31_RS12410 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY31_RS12415 ENOG4108VYJ response regulator receiver protein GPY31_RS12420 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GPY31_RS12425 ENOG4105CBS Chea signal transduction histidine kinase GPY31_RS12430 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPY31_RS12435 ENOG4107QJE Chromosome Partitioning Protein GPY31_RS12445 ENOG4108V3W Chemotaxis protein, CheW GPY31_RS12455 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GPY31_RS12460 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GPY31_RS12465 ENOG41060IM Heme exporter protein GPY31_RS12470 ENOG4105X3C heme exporter protein GPY31_RS12475 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) GPY31_RS12480 ENOG4105DA4 cytochrome c-type biogenesis protein GPY31_RS12485 ENOG4107QX9 Thiol disulfide interChange protein GPY31_RS12490 ENOG4108M1T Cytochrome c-type biogenesis protein GPY31_RS12500 ENOG410903C (LipO)protein GPY31_RS12505 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY31_RS12510 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY31_RS12525 ENOG4105CHU acetyl-coa acetyltransferase GPY31_RS12530 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GPY31_RS12540 ENOG4107QXK peptidase GPY31_RS12545 ENOG4108BY2 phosphohistidine phosphatase GPY31_RS12550 ENOG4108DG9 Smr protein MutS2 GPY31_RS12555 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GPY31_RS12560 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GPY31_RS12565 ENOG4105EN6 Membrane GPY31_RS12575 ENOG4108BPE -transporting atpase GPY31_RS12580 ENOG4105MH2 YfcL protein GPY31_RS12590 ENOG4105Q8W reductase GPY31_RS12595 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GPY31_RS12600 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY31_RS12605 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) GPY31_RS12610 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPY31_RS12620 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GPY31_RS12625 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GPY31_RS12630 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GPY31_RS12635 ENOG4108S3P Sporulation domain protein GPY31_RS12640 ENOG4105E96 Colicin v production protein GPY31_RS12645 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GPY31_RS12650 ENOG4105EJC lysr family transcriptional regulator GPY31_RS12655 ENOG4105I93 response regulator GPY31_RS12665 ENOG4105WD1 Membrane GPY31_RS12670 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GPY31_RS12675 ENOG4107QMP dna polymerase iii subunits gamma and tau GPY31_RS12680 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GPY31_RS12685 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GPY31_RS12690 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GPY31_RS12695 ENOG4105C44 Serine transporter GPY31_RS12700 ENOG4105KME endoribonuclease L-psp GPY31_RS12705 ENOG4105CEM UPF0597 protein GPY31_RS12715 ENOG4105KRS Proteinase inhibitor GPY31_RS12720 ENOG4105Y3U Transglycosylase-associated protein GPY31_RS12725 ENOG4108ZZ3 UPF0260 protein GPY31_RS12740 ENOG4108UYE Lactoylglutathione lyase GPY31_RS12750 ENOG4105G6Z alkaline phosphatase GPY31_RS12770 ENOG4105DHI Methyltransferase GPY31_RS12775 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS12780 ENOG4105DSB aldose 1-epimerase GPY31_RS12785 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY31_RS12790 ENOG4105E0X reductase GPY31_RS12800 ENOG4105VUT cytoplasmic protein GPY31_RS12805 ENOG4105HDK L-asparaginase GPY31_RS12810 ENOG4105D07 Signal peptide peptidase, SppA GPY31_RS12815 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY31_RS12820 ENOG41069NU Nitroreductase GPY31_RS12825 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY31_RS12840 ENOG4108RU0 short-chain dehydrogenase reductase GPY31_RS12845 ENOG4105DGU Histone deacetylase GPY31_RS12855 ENOG4105E68 Sulfatase GPY31_RS12860 ENOG4105YDX UPF0352 protein GPY31_RS12865 ENOG4106V8H Nucleoid-associated protein GPY31_RS12880 ENOG4105DFD Na H antiporter GPY31_RS12885 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPY31_RS12890 ENOG4105EYW Ion transport protein GPY31_RS12895 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GPY31_RS12900 ENOG4108EKI Dehydrogenase GPY31_RS12915 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GPY31_RS12920 ENOG4105M2J Glutaredoxin GPY31_RS12930 ENOG4105D3Y Na H antiporter GPY31_RS12935 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GPY31_RS12950 ENOG4105EIY sodium-type flagellar protein motY GPY31_RS12955 ENOG4106WH9 Protein of unknown function (DUF2753) GPY31_RS12960 ENOG4108UYE Lactoylglutathione lyase GPY31_RS12965 ENOG4105CSM endonuclease III GPY31_RS12970 ENOG4105DZB Electron transport complex GPY31_RS12975 ENOG4108UQQ Electron transport complex GPY31_RS12980 ENOG4105D6A Electron transport complex GPY31_RS12990 ENOG4108R3D Electron transport complex GPY31_RS12995 ENOG4105DGN Electron transport complex GPY31_RS13010 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GPY31_RS13015 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS13025 ENOG4105CHW UPF0052 protein GPY31_RS13030 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPY31_RS13035 ENOG4108RIR Molybdenum cofactor biosynthesis protein GPY31_RS13040 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPY31_RS13045 ENOG4105M00 molybdopterin converting factor, subunit 1 GPY31_RS13050 ENOG4108ZAF Molybdopterin GPY31_RS13055 ENOG4107QSI ABC, transporter GPY31_RS13060 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY31_RS13065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY31_RS13070 ENOG4105C3U ABC transporter GPY31_RS13075 ENOG4108JQ7 (ABC) transporter GPY31_RS13080 ENOG4105CHF Glutathione S-transferase GPY31_RS13090 ENOG4107PU6 Membrane GPY31_RS13095 ENOG4108DNC Involved in acetate metabolism (By similarity) GPY31_RS13100 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPY31_RS13105 ENOG4105PQ6 UPF0208 membrane protein GPY31_RS13115 ENOG4105C7J ABC transporter, permease GPY31_RS13120 ENOG4108JJB ABC transporter GPY31_RS13125 ENOG4107R28 alpha amylase, catalytic region GPY31_RS13130 ENOG4105BZU Histidine kinase GPY31_RS13135 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GPY31_RS13140 ENOG4106RHG Yeca family GPY31_RS13145 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) GPY31_RS13150 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GPY31_RS13155 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) GPY31_RS13165 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GPY31_RS13170 ENOG4105D1F ATP-binding protein GPY31_RS13175 ENOG4105DBI uridine monophosphokinase GPY31_RS13185 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GPY31_RS13195 ENOG4105CHH sulfate transporter GPY31_RS13200 ENOG4105C03 ribonuclease GPY31_RS13205 ENOG4105EI2 Pseudouridine synthase GPY31_RS13210 ENOG4108UHJ MAF-like protein GPY31_RS13215 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GPY31_RS13220 ENOG4105VGS 50s ribosomal protein l32 GPY31_RS13225 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GPY31_RS13230 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GPY31_RS13235 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GPY31_RS13240 ENOG4105CHR reductase GPY31_RS13245 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GPY31_RS13250 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY31_RS13260 ENOG4105HHA aminodeoxychorismate lyase GPY31_RS13265 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GPY31_RS13270 ENOG4107QRG dna polymerase iii GPY31_RS13275 ENOG4105F8V Hydrolase, tatD family GPY31_RS13280 ENOG4105CI1 PTS System GPY31_RS13300 ENOG4105C8J )-transporter GPY31_RS13315 ENOG4108NRW Phospholipase, patatin family GPY31_RS13320 ENOG4105CA9 Pyruvate kinase GPY31_RS13325 ENOG4105DAG ROK family GPY31_RS13330 ENOG4107R88 Chemotaxis protein (CheV) GPY31_RS13335 ENOG4105C0B DNA polymerase III (alpha subunit) GPY31_RS13350 ENOG4105UBK short-chain dehydrogenase reductase GPY31_RS13355 ENOG4105ERU peptidase GPY31_RS13360 ENOG4105CAT Cytidine monophosphate kinase GPY31_RS13365 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GPY31_RS13370 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY31_RS13375 ENOG4105Q4A inner membrane protein yciS GPY31_RS13380 ENOG4105CFV Tetratricopeptide repeat protein GPY31_RS13385 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GPY31_RS13390 ENOG4108J59 Extracellular solute-binding protein, family 5 GPY31_RS13405 ENOG4105CKK Glycosyl transferase, family 2 GPY31_RS13415 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) GPY31_RS13425 ENOG4105DY2 Paraquat-inducible protein b GPY31_RS13430 ENOG4105F1S paraquat-inducible protein a GPY31_RS13435 ENOG4105NQN cytochrome C GPY31_RS13445 ENOG4105DB1 molybdopterin oxidoreductase GPY31_RS13450 ENOG4106WHD Tetrathionate reductase GPY31_RS13455 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GPY31_RS13460 ENOG4106AFQ Histidine kinase GPY31_RS13465 ENOG4108ZXC Two component transcriptional regulator, luxr family GPY31_RS13470 ENOG4105EXG Transcriptional regulator GPY31_RS13480 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GPY31_RS13485 ENOG4105N6Y Thioredoxin GPY31_RS13500 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GPY31_RS13515 ENOG4105DJY efflux transporter, rnd family, mfp subunit GPY31_RS13525 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY31_RS13535 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY31_RS13540 ENOG4108W2Y isochorismatase GPY31_RS13545 ENOG41063TF transcriptional regulator (AraC GPY31_RS13555 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GPY31_RS13565 ENOG4105J12 Multidrug resistance protein mdtN GPY31_RS13570 ENOG4105JQN Transcriptional regulator GPY31_RS13590 ENOG41062D9 Histidine kinase GPY31_RS13595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY31_RS13605 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS13610 ENOG4105CCT upf0313 protein GPY31_RS13630 ENOG4105DZ2 Transcriptional regulator GPY31_RS13640 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GPY31_RS13650 ENOG4105K9H YciI-like protein GPY31_RS13655 ENOG4105NAU thioesterase Superfamily protein GPY31_RS13660 ENOG4107835 probably involved in intracellular septation (By similarity) GPY31_RS13670 ENOG4105BZU Histidine kinase GPY31_RS13680 ENOG4105CK2 sodium dicarboxylate symporter GPY31_RS13690 ENOG4105CEY Amp-dependent synthetase and ligase GPY31_RS13695 ENOG4107RYR Transcriptional regulator, Crp Fnr family GPY31_RS13705 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GPY31_RS13710 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GPY31_RS13715 ENOG4105DK0 Indole-3-glycerol phosphate synthase GPY31_RS13720 ENOG4108I0Q anthranilate phosphoribosyltransferase GPY31_RS13725 ENOG4105DDQ anthranilate synthase GPY31_RS13730 ENOG4105CRQ synthase (Component I) GPY31_RS13740 ENOG4105DB7 PHP domain protein GPY31_RS13745 ENOG4107RTD sua5 ycio yrdc ywlc family protein GPY31_RS13755 ENOG4105FE9 pseudouridine synthase GPY31_RS13765 ENOG4108W5H UPF0263 protein GPY31_RS13770 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GPY31_RS13780 ENOG4105CQ2 DNA polymerase GPY31_RS13785 ENOG4105WH1 Two component transcriptional regulator luxr family GPY31_RS13790 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GPY31_RS13830 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) GPY31_RS13855 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPY31_RS13860 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPY31_RS13865 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GPY31_RS13870 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY31_RS13885 ENOG4105EAU Plays a role in nitrite reduction (By similarity) GPY31_RS13895 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GPY31_RS13900 ENOG4105DVI reductase, NrfD GPY31_RS13905 ENOG4105DA4 cytochrome c-type biogenesis protein GPY31_RS13910 ENOG4107QX9 Thiol disulfide interChange protein GPY31_RS13915 ENOG4108DMF Cytochrome C biogenesis protein GPY31_RS13925 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GPY31_RS13950 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GPY31_RS13955 ENOG4105EAQ (twin-arginine translocation) pathway signal GPY31_RS13960 ENOG4105C5X domain protein GPY31_RS13975 ENOG4105CH5 extracellular solute-binding protein, family 7 GPY31_RS13985 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY31_RS14000 ENOG41067TZ transcriptional regulator, MarR family GPY31_RS14005 ENOG4105C94 Transporter GPY31_RS14010 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS14030 ENOG4105CGF Aromatic amino acid aminotransferase GPY31_RS14055 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY31_RS14065 ENOG4105C5S asparaginyl-tRNA synthetase GPY31_RS14070 ENOG4108N3W hemolysin secretion protein GPY31_RS14075 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GPY31_RS14085 ENOG4105BZU Histidine kinase GPY31_RS14090 ENOG4105EJQ L-serine dehydratase GPY31_RS14095 ENOG4105C44 Serine transporter GPY31_RS14100 ENOG4105P8F nudix hydrolase GPY31_RS14110 ENOG4105BZU Histidine kinase GPY31_RS14115 ENOG4105CRQ synthase (Component I) GPY31_RS14135 ENOG4105CM6 amino acid regulated cytosolic protein GPY31_RS14140 ENOG4106K28 UPF0283 membrane protein GPY31_RS14150 ENOG4105D9U N-acetyltransferase GPY31_RS14350 ENOG4105N14 lysine exporter protein LysE YggA GPY31_RS14355 ENOG41068WN GPY31_RS14375 ENOG4107S6Z Na H antiporter GPY31_RS14380 ENOG4105CFQ glutamine synthetase GPY31_RS14390 ENOG4108Z86 Glutamine amidotransferase GPY31_RS14395 ENOG4107VRI Transcriptional regulator GPY31_RS14400 ENOG4105C26 Dehydrogenase GPY31_RS14405 ENOG4105CJP fad dependent oxidoreductase GPY31_RS14415 ENOG4105DWY Agmatine deiminase GPY31_RS14420 ENOG4105C26 Dehydrogenase GPY31_RS14425 ENOG4108JPW Aminotransferase GPY31_RS14430 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GPY31_RS14440 ENOG4105BZU Histidine kinase GPY31_RS14450 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GPY31_RS14465 ENOG4108ZT1 Transcriptional regulator GPY31_RS14470 ENOG4105MSB protein, conserved in bacteria GPY31_RS14490 ENOG4108UW5 maltose o-acetyltransferase GPY31_RS14505 ENOG4105BZU Histidine kinase GPY31_RS14510 ENOG4105BZU Histidine kinase GPY31_RS14520 ENOG41090FY type IV pilus biogenesis stability protein PilW GPY31_RS14525 ENOG4105CVG Homoserine O-transsuccinylase GPY31_RS14540 ENOG4105E5D amino acid GPY31_RS14550 ENOG4105D1S lipid A biosynthesis GPY31_RS14555 ENOG4105CTD carboxy-peptidase GPY31_RS14560 ENOG410829K Lysine exporter protein (Lyse ygga) GPY31_RS14570 ENOG4105BZG amino acid carrier protein GPY31_RS14595 ENOG4105E0M Sulfatase GPY31_RS14600 ENOG4105DHQ Histidine kinase GPY31_RS14635 ENOG4105GIJ Glycine betaine GPY31_RS14640 ENOG4108HQS Glycine betaine GPY31_RS14645 ENOG4108IJ7 Glycine betaine GPY31_RS14660 ENOG4105C94 Transporter GPY31_RS14665 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GPY31_RS14670 ENOG4108JPW Aminotransferase GPY31_RS14675 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GPY31_RS14680 ENOG4105CZK Aspartate kinase GPY31_RS14685 ENOG4105CA0 peroxidase GPY31_RS14700 ENOG4107V40 secretion protein, HlyD family GPY31_RS14715 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPY31_RS14720 ENOG4108V9W transcriptional regulatory protein GPY31_RS14725 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GPY31_RS14730 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) GPY31_RS14735 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GPY31_RS14755 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GPY31_RS14760 ENOG4105C26 Dehydrogenase GPY31_RS14780 ENOG4108KB1 transcriptional regulator, arac family GPY31_RS14810 ENOG41066XE Type III export protein GPY31_RS14890 ENOG4105ENX hydrolase GPY31_RS14895 ENOG4105ENX hydrolase GPY31_RS14900 ENOG4105EQ2 LysR family Transcriptional regulator GPY31_RS15010 ENOG4105EJ9 Membrane GPY31_RS15040 ENOG4105CR4 methylisocitrate lyase GPY31_RS15045 ENOG4105BZN citrate synthase GPY31_RS15050 ENOG4108I0Z Aconitate hydratase GPY31_RS15055 ENOG4105C7F AcnD-accessory protein PrpF GPY31_RS15060 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY31_RS15065 ENOG4108R6G acetyltransferase GPY31_RS15080 ENOG410667J hydrolase GPY31_RS15085 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GPY31_RS15090 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GPY31_RS15095 ENOG4105BZU Histidine kinase GPY31_RS15105 ENOG4105CDV Ompa motb domain protein GPY31_RS15120 ENOG4105CDV Ompa motb domain protein GPY31_RS15135 ENOG4105DR4 Methyltransferase GPY31_RS15140 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS15145 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GPY31_RS15150 ENOG4108Z0T Part of a sulfur-relay system (By similarity) GPY31_RS15160 ENOG4108MN8 Membrane GPY31_RS15165 ENOG4105CDA abc transporter atp-binding protein GPY31_RS15170 ENOG4105DRP amino acid AbC transporter GPY31_RS15175 ENOG4105EZ7 amino acid ABC transporter GPY31_RS15180 ENOG4107QXX ABC transporter GPY31_RS15195 ENOG4108VPT UPF0234 protein GPY31_RS15200 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY31_RS15220 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GPY31_RS15225 ENOG4105DY2 Paraquat-inducible protein b GPY31_RS15230 ENOG4105H2K paraquat-inducible protein a GPY31_RS15235 ENOG4105BZ1 (ABC) transporter GPY31_RS15240 ENOG4108ZGC gaf domain protein GPY31_RS15245 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) GPY31_RS15250 ENOG4105CN1 protease GPY31_RS15260 ENOG4105CD8 aminopeptidase N GPY31_RS15270 ENOG4105C7I Dehydrogenase GPY31_RS15275 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GPY31_RS15280 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GPY31_RS15290 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GPY31_RS15300 ENOG4105C5H ABC transporter GPY31_RS15315 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) GPY31_RS15320 ENOG4105DAN ATP-dependent protease GPY31_RS15325 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) GPY31_RS15445 ENOG4105BZU Histidine kinase GPY31_RS15460 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i GPY31_RS15475 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) GPY31_RS15485 ENOG4105C59 p-type ATPase GPY31_RS15500 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GPY31_RS15505 ENOG4105Q9Y Universal stress protein GPY31_RS15515 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GPY31_RS15535 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS15540 ENOG4105F38 ABC transporter, permease GPY31_RS15545 ENOG4105D38 putrescine abc transporter GPY31_RS15550 ENOG4107RUE extracellular solute-binding protein family 1 GPY31_RS15555 ENOG4107RUE extracellular solute-binding protein family 1 GPY31_RS15560 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GPY31_RS15595 ENOG4105CNA YD repeat protein GPY31_RS15610 ENOG4105QAX Iron-sulfur GPY31_RS15615 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GPY31_RS15625 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GPY31_RS15650 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GPY31_RS15655 ENOG4105C5H ABC transporter GPY31_RS15665 ENOG4105BZU Histidine kinase GPY31_RS15670 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS15690 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS15695 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GPY31_RS15700 ENOG4105CVM Molybdenum cofactor synthesis domain protein GPY31_RS15710 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GPY31_RS15715 ENOG4106IUH DTW domain containing protein GPY31_RS15750 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS15755 ENOG4107TT5 NLP P60 protein GPY31_RS15765 ENOG4105BZU Histidine kinase GPY31_RS15770 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPY31_RS15775 ENOG4105FGM Fructosamine kinase GPY31_RS15785 ENOG4108R6K riboflavin synthase, subunit alpha GPY31_RS15790 ENOG4107QI1 Mate efflux family protein GPY31_RS15805 ENOG41082AN stage II sporulation protein GPY31_RS15815 ENOG4107V1M polysaccharide export protein GPY31_RS15835 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS15880 ENOG4105CPK Glycosyl transferase (Group 1 GPY31_RS15885 ENOG4105CND Glycosyl transferase, family 2 GPY31_RS15900 ENOG4105C94 Transporter GPY31_RS15915 ENOG4105CQ7 ATP-dependent helicase GPY31_RS15920 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GPY31_RS15930 ENOG4108NEM leader-binding protein dmsD GPY31_RS15935 ENOG4107KGK dmso reductase anchor subunit GPY31_RS15940 ENOG4105QAX Iron-sulfur GPY31_RS15945 ENOG4107QY8 reductase GPY31_RS15975 ENOG4105BZU Histidine kinase GPY31_RS15985 ENOG4105CFG Acts as a chaperone (By similarity) GPY31_RS15990 ENOG4105CFG Acts as a chaperone (By similarity) GPY31_RS16020 ENOG4105BZ1 (ABC) transporter GPY31_RS16025 ENOG4105BZ1 (ABC) transporter GPY31_RS16050 ENOG4105E0U tyrosine-specific transport protein GPY31_RS16065 ENOG4105DHT Metal Dependent Phosphohydrolase GPY31_RS16140 ENOG4105EW9 transcriptional regulator AsnC family GPY31_RS16175 ENOG4105D9P serine threonine protein kinase GPY31_RS16200 ENOG4105CS6 Rhs element vgr protein GPY31_RS16205 ENOG4108WC9 type VI secretion system effector, hcp1 family GPY31_RS16210 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY31_RS16215 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS16240 ENOG4105DR5 peptidase GPY31_RS16250 ENOG4105EE5 Membrane protein terC GPY31_RS16260 ENOG41076CZ activating enzyme GPY31_RS16265 ENOG4105G0K glycine radical enzyme YjjI family GPY31_RS16275 ENOG4105CPI Metal Dependent Phosphohydrolase GPY31_RS16280 ENOG4105BZU Histidine kinase GPY31_RS16285 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS16290 ENOG4105BZU Histidine kinase GPY31_RS16295 ENOG4105C8P )-transporter GPY31_RS16330 ENOG4105DUM transcriptional regulator, lysR family GPY31_RS16350 ENOG4105Y49 secretion protein, HlyD family GPY31_RS16410 ENOG410805Y Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GPY31_RS16550 ENOG4108N0N Phage Terminase Large Subunit GPY31_RS16590 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GPY31_RS16595 ENOG4105VEQ Cold shock protein GPY31_RS16700 ENOG4108RXX maleylacetoacetate isomerase GPY31_RS16710 ENOG4105F1J Homogentisate 1,2-dioxygenase GPY31_RS16715 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GPY31_RS16720 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GPY31_RS16725 ENOG4107QSI ABC, transporter GPY31_RS16730 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY31_RS16735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY31_RS16740 ENOG4105C3U ABC transporter GPY31_RS16745 ENOG4108JQ7 (ABC) transporter GPY31_RS16760 ENOG4107MM9 BNR Asp-box repeat-containing protein GPY31_RS16770 ENOG4105D38 putrescine abc transporter GPY31_RS16775 ENOG4105F38 ABC transporter, permease GPY31_RS16780 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS16785 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GPY31_RS16790 ENOG4105CIF Ornithine Cyclodeaminase GPY31_RS16810 ENOG4105CTU Proline racemase GPY31_RS16840 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) GPY31_RS16845 ENOG4108VKG metal-dependent hydrolase GPY31_RS16850 ENOG4105KPE licD family GPY31_RS16860 ENOG4107XDJ Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GPY31_RS16880 ENOG4107RSM transcriptional regulator GPY31_RS16900 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS16905 ENOG4108IU2 vtamin B12-transporter permease GPY31_RS16910 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) GPY31_RS16935 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GPY31_RS16940 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GPY31_RS16945 ENOG4105K4T epimerase GPY31_RS16950 ENOG4108ETY sodium dicarboxylate symporter GPY31_RS16955 ENOG4105CJB Exodeoxyribonuclease I GPY31_RS16960 ENOG4105VAW lrga family GPY31_RS16965 ENOG41067MG lrgb family GPY31_RS16970 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) GPY31_RS16975 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GPY31_RS16980 ENOG4105FQ6 thiopurine methyltransferase GPY31_RS16990 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY31_RS17005 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GPY31_RS17010 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GPY31_RS17015 ENOG4105BZU Histidine kinase GPY31_RS17045 ENOG4105K8R UPF0145 protein GPY31_RS17050 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GPY31_RS17055 ENOG41082NX 50s ribosomal protein l35 GPY31_RS17060 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GPY31_RS17065 ENOG4105C22 threonyL-tRNA synthetase GPY31_RS17080 ENOG4105CZE histidine utilization repressor GPY31_RS17085 ENOG4105CI2 imidazolone-5-propionate hydrolase GPY31_RS17090 ENOG41088SP formiminoglutamate hydrolase GPY31_RS17100 ENOG4105C84 Histidine ammonia-lyase GPY31_RS17115 ENOG4105CQB FAD linked oxidase domain protein GPY31_RS17130 ENOG4105CDV Ompa motb domain protein GPY31_RS17150 ENOG4105C8V SAICAR synthetase GPY31_RS17165 ENOG4105HDD phospholipase GPY31_RS17170 ENOG4105CQ7 ATP-dependent helicase GPY31_RS17175 ENOG4107R1I NAD-dependent malic enzyme GPY31_RS17180 ENOG4107GZ4 SanA protein GPY31_RS17185 ENOG4105C8P )-transporter GPY31_RS17190 ENOG4105BZU Histidine kinase GPY31_RS17210 ENOG4105C3M thioredoxin reductase GPY31_RS17215 ENOG4108JJ9 ABC, transporter GPY31_RS17220 ENOG4108JJ8 (ABC) transporter GPY31_RS17225 ENOG4105BZC d-serine deaminase GPY31_RS17230 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GPY31_RS17240 ENOG4105BZU Histidine kinase GPY31_RS17270 ENOG4105DWU Membrane GPY31_RS17280 ENOG4105DY8 decarboxylase GPY31_RS17285 ENOG4106KNT transcriptional regulator GPY31_RS17300 ENOG41090BQ Glutaredoxin GPY31_RS17305 ENOG4105D0C transport protein GPY31_RS17310 ENOG4105RKW reductase (By GPY31_RS17315 ENOG4107QPN acyl-Coa dehydrogenase GPY31_RS17320 ENOG41067SE Tetr family transcriptional regulator GPY31_RS17325 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GPY31_RS17340 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GPY31_RS17345 ENOG4107QI1 Mate efflux family protein GPY31_RS17350 ENOG4105CGD Nad-dependent epimerase dehydratase GPY31_RS17355 ENOG4105CUW cytochrome C-TYPE protein GPY31_RS17385 ENOG4105C2C drug resistance transporter, Bcr CflA GPY31_RS17390 ENOG4105I08 Pseudouridine synthase GPY31_RS17395 ENOG4105CFI type iii restriction protein res subunit GPY31_RS17405 ENOG4105ETX regulatoR GPY31_RS17410 ENOG4105EB3 Histidine kinase GPY31_RS17415 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GPY31_RS17430 ENOG4105CGH 5'-nucleotidase GPY31_RS17445 ENOG4105XZD Fe-S protein GPY31_RS17455 ENOG4108ZXC Two component transcriptional regulator, luxr family GPY31_RS17460 ENOG4106AFQ Histidine kinase GPY31_RS17470 ENOG4105BZ8 glutamate synthase GPY31_RS17480 ENOG4108RSN SNARE associated Golgi GPY31_RS17485 ENOG4105VNH ABC transporter solute-binding protein GPY31_RS17490 ENOG4105CXZ ABC transporter, permease GPY31_RS17495 ENOG4108VGW abc transporter atp-binding protein GPY31_RS17500 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GPY31_RS17515 ENOG4108JUA Transcriptional regulator GPY31_RS17520 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) GPY31_RS17525 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GPY31_RS17535 ENOG4108W1A pseudouridine synthase GPY31_RS17545 ENOG4105C8J )-transporter GPY31_RS17550 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GPY31_RS17555 ENOG4105C28 cystathionine GPY31_RS17560 ENOG4107IFA Lipase (EC 3.1.1.3) GPY31_RS17570 ENOG4108R3E Dna-3-methyladenine glycosylase i GPY31_RS17585 ENOG410624X efflux transporter, rnd family, mfp subunit GPY31_RS17590 ENOG4105FM1 phage shock protein C GPY31_RS17595 ENOG4105YYT phage shock protein B GPY31_RS17600 ENOG41087YS Phage shock protein A GPY31_RS17605 ENOG4105E51 psp operon transcriptional activator GPY31_RS17610 ENOG4108J59 Extracellular solute-binding protein, family 5 GPY31_RS17615 ENOG4108I5W peptide transport system, permease protein GPY31_RS17620 ENOG4108EU3 peptide transport system, permease GPY31_RS17625 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GPY31_RS17630 ENOG4108JQ2 peptide transport system atp-binding protein GPY31_RS17640 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GPY31_RS17655 ENOG4108J2R molybdopterin oxidoreductase GPY31_RS17670 ENOG4105C4B ABC transporter, permease GPY31_RS17680 ENOG4105TMB Formate nitrite transporter GPY31_RS17705 ENOG4105GFG DUF218 domain GPY31_RS17710 ENOG4107104 thymidine kinase GPY31_RS17715 ENOG4105C8N cysteinyl-tRNA synthetase GPY31_RS17720 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY31_RS17725 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) GPY31_RS17730 ENOG4105D58 Diguanylate phosphodiesterase GPY31_RS17740 ENOG4105K5B UPF0225 protein GPY31_RS17745 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GPY31_RS17750 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GPY31_RS17760 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GPY31_RS17765 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GPY31_RS17770 ENOG4105CIH Imidazole acetol-phosphate transaminase GPY31_RS17775 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GPY31_RS17780 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GPY31_RS17785 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS17795 ENOG4107S6Z Na H antiporter GPY31_RS17800 ENOG4108YX2 DNA-binding protein GPY31_RS17805 ENOG4107RE1 Inosine-guanosine kinase GPY31_RS17815 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GPY31_RS17820 ENOG41075W9 High frequency lysogenization protein HflD homolog GPY31_RS17825 ENOG4107QTF adenylosuccinate lyase GPY31_RS17850 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GPY31_RS17865 ENOG4107FW0 short-chain dehydrogenase reductase GPY31_RS17875 ENOG4105D0M Protease HtpX homolog GPY31_RS17885 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GPY31_RS17895 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPY31_RS17900 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GPY31_RS17910 ENOG4105KSC Transcriptional regulator, TraR DksA family GPY31_RS17915 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GPY31_RS17920 ENOG4105D1H recombination factor protein RarA GPY31_RS17925 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) GPY31_RS17930 ENOG4105CNU cell division protein FtsK GPY31_RS17935 ENOG4105EW9 transcriptional regulator AsnC family GPY31_RS17940 ENOG4105DCF alanine dehydrogenase GPY31_RS17950 ENOG4107R11 Transcriptional regulator GPY31_RS17960 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GPY31_RS17995 ENOG4105BZS acriflavin resistance protein GPY31_RS18000 ENOG4105C1P efflux transporter, rnd family, mfp subunit GPY31_RS18015 ENOG4108N3W hemolysin secretion protein GPY31_RS18025 ENOG4108RNS Exports L-alanine (By similarity) GPY31_RS18030 ENOG4105BZU Histidine kinase GPY31_RS18040 ENOG4106032 Glutathionylspermidine synthase GPY31_RS18050 ENOG4105Z6B inner membrane protein yjfl GPY31_RS18060 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GPY31_RS18065 ENOG4105UFD tol-pal system protein YbgF GPY31_RS18070 ENOG4105KCK Peptidoglycan-associated lipoprotein GPY31_RS18075 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) GPY31_RS18085 ENOG4105M8F Biopolymer transport protein exbD tolR GPY31_RS18090 ENOG4105E02 MotA TolQ exbB proton channel GPY31_RS18095 ENOG4107YD3 Thioesterase GPY31_RS18110 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY31_RS18115 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY31_RS18120 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GPY31_RS18125 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GPY31_RS18130 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS18135 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GPY31_RS18140 ENOG4105C9M aspartyl-trna synthetase GPY31_RS18145 ENOG41081XQ Conserved Protein GPY31_RS18150 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) GPY31_RS18155 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GPY31_RS18165 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY31_RS18175 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY31_RS18185 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) GPY31_RS18190 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GPY31_RS18195 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) GPY31_RS18200 ENOG4106371 Methyltransferase GPY31_RS18205 ENOG4107S90 membrAne GPY31_RS18210 ENOG4106WF9 DNA-binding transcriptional regulator TorR GPY31_RS18215 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GPY31_RS18220 ENOG4105ETE Transcriptional regulator (LacI family GPY31_RS18225 ENOG4105HP8 regulator of competence-specific genes GPY31_RS18245 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GPY31_RS18250 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GPY31_RS18255 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY31_RS18260 ENOG4105RKX Protein of unknown function (DUF2498) GPY31_RS18265 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GPY31_RS18275 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GPY31_RS18280 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate GPY31_RS18285 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GPY31_RS18295 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY31_RS18300 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GPY31_RS18305 ENOG4105VEQ Cold shock protein GPY31_RS18315 ENOG4108R99 pseudouridine synthase GPY31_RS18330 ENOG4105DVT helicase GPY31_RS18335 ENOG4105EJ9 Membrane GPY31_RS18340 ENOG4108URS primosomal replication protein n'' GPY31_RS18345 ENOG4106428 Protein of unknown function (DUF2496) GPY31_RS18350 ENOG4105CGK Exodeoxyribonuclease III GPY31_RS18365 ENOG4105DSP amino acid AbC transporter GPY31_RS18370 ENOG4105E89 ABC transporter GPY31_RS18375 ENOG4108JEH abc transporter atp-binding protein GPY31_RS18395 ENOG4105C6N Formate acetyltransferase GPY31_RS18405 ENOG4105F1A Pyruvate formate-lyase GPY31_RS18415 ENOG4105XWI UPF0304 protein GPY31_RS18425 ENOG4105CYN Serine protein kinase GPY31_RS18430 ENOG4106AKX UPF0229 protein GPY31_RS18435 ENOG4105ED1 spovr family GPY31_RS18440 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GPY31_RS18445 ENOG4105W49 UPF0434 protein GPY31_RS18450 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GPY31_RS18455 ENOG4105BZ1 (ABC) transporter GPY31_RS18460 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GPY31_RS18470 ENOG4105D60 lipoprotein releasing system transmembrane protein GPY31_RS18475 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GPY31_RS18480 ENOG4105D60 lipoprotein releasing system transmembrane protein GPY31_RS18490 ENOG4108JA2 transcriptioN-repair coupling factor GPY31_RS18505 ENOG4105CEP NADH dehydrogenase GPY31_RS18515 ENOG4105D0Y UPF0227 protein GPY31_RS18540 ENOG4105K59 histidine triad (HIT) protein GPY31_RS18545 ENOG4108NVR Methyl-accepting chemotaxis GPY31_RS18560 ENOG4107SXA Phosphorylase GPY31_RS18570 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY31_RS18580 ENOG4105DZ0 fad dependent oxidoreductase GPY31_RS18585 ENOG4108Z4U Ferredoxin GPY31_RS18600 ENOG4108KHX Diguanylate cyclase GPY31_RS18615 ENOG4108MNP Glycoprotein polysaccharide metabolism GPY31_RS18620 ENOG4105C29 acyl-CoA thioesterase GPY31_RS18630 ENOG4108XM1 transcriptional regulator AsnC family GPY31_RS18660 ENOG4105BZS acriflavin resistance protein GPY31_RS18665 ENOG4105ENT Efflux transporter rnd family, mfp subunit GPY31_RS18710 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) GPY31_RS18715 ENOG4105HMI Membrane GPY31_RS18725 ENOG4105CEY Amp-dependent synthetase and ligase GPY31_RS18730 ENOG4105DNI Converts SHCHC to OSB (By similarity) GPY31_RS18735 ENOG4108IPT Naphthoate synthase GPY31_RS18740 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GPY31_RS18745 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GPY31_RS18750 ENOG4105E4F Isochorismate synthase GPY31_RS18755 ENOG4105CHM Aminotransferase GPY31_RS18760 ENOG4105DK2 UPF0207 protein GPY31_RS18765 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GPY31_RS18780 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GPY31_RS18785 ENOG4105EIN peptidylprolyl cis-trans isomerase GPY31_RS18790 ENOG4105K70 DNA-binding protein GPY31_RS18795 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GPY31_RS18800 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GPY31_RS18805 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GPY31_RS18810 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GPY31_RS18815 ENOG4105CQZ Histidine kinase GPY31_RS18830 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY31_RS18835 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ GPY31_RS18840 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GPY31_RS18845 ENOG4105CNG UPF0061 protein GPY31_RS18870 ENOG4107ZYR domain protein GPY31_RS18875 ENOG4105C1J atp-dependent rna helicase GPY31_RS18915 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GPY31_RS18935 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GPY31_RS18940 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GPY31_RS18945 ENOG4105C84 Histidine ammonia-lyase GPY31_RS18970 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY31_RS18975 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GPY31_RS18980 ENOG4105C2D reductase GPY31_RS18985 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY31_RS19000 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GPY31_RS19005 ENOG4105D9N nucleoside GPY31_RS19010 ENOG4105CC0 LysR family Transcriptional regulator GPY31_RS19015 ENOG4105CVE Lytic murein transglycosylase GPY31_RS19020 ENOG4105VNG YcgL domain-containing protein GPY31_RS19025 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GPY31_RS19030 ENOG4107QMS site-determining protein GPY31_RS19035 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GPY31_RS19040 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GPY31_RS19045 ENOG4105CEY Amp-dependent synthetase and ligase GPY31_RS19050 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GPY31_RS19065 ENOG41072GX Peptidase M22 Glycoprotease GPY31_RS19070 ENOG4105DVT helicase GPY31_RS19075 ENOG4105CIY formyltetrahydrofolate deformylase GPY31_RS19080 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GPY31_RS19090 ENOG4106ZCM YecM protein GPY31_RS19100 ENOG4105C75 arginyL-tRNA synthetase GPY31_RS19115 ENOG4105CE1 Ferrous iron transport protein b GPY31_RS19120 ENOG4105XFK Ferrous iron transport protein A GPY31_RS19135 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GPY31_RS19140 ENOG4105NXV High-affinity zinc uptake system protein GPY31_RS19145 ENOG4105FDK ABC transporter GPY31_RS19150 ENOG4105FAV ABC, transporter GPY31_RS19155 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GPY31_RS19160 ENOG4105CMV Succinyl-CoA synthetase subunit beta GPY31_RS19165 ENOG4105C7S Dehydrogenase GPY31_RS19170 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GPY31_RS19175 ENOG4105E33 succinate dehydrogenase GPY31_RS19180 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GPY31_RS19185 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GPY31_RS19190 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GPY31_RS19195 ENOG4105BZN citrate synthase GPY31_RS19200 ENOG4107QNR UPF0135 protein GPY31_RS19210 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GPY31_RS19215 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GPY31_RS19220 ENOG4105EV9 Alpha Beta Hydrolase GPY31_RS19230 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GPY31_RS19240 ENOG41090R7 Ferric uptake GPY31_RS19245 ENOG4105CX6 glutaminyL-tRNA synthetase GPY31_RS19250 ENOG4105CI1 PTS System GPY31_RS19260 ENOG4105CE4 GlcNAc 6-P deacetylase GPY31_RS19265 ENOG4105E2R ROK family GPY31_RS19270 ENOG4105CKD glutathione-regulated potassium-efflux system protein GPY31_RS19275 ENOG4105CAQ asparagine synthetase GPY31_RS19280 ENOG4105MDZ Transcriptional activator rfaH GPY31_RS19285 ENOG4105DUX Transporter GPY31_RS19290 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GPY31_RS19295 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GPY31_RS19300 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GPY31_RS19305 ENOG4108DQ1 activator toxR GPY31_RS19325 ENOG4108RE9 Phosphodiesterase GPY31_RS19355 ENOG4105ECP epimerase GPY31_RS19360 ENOG4105E1F short-chain dehydrogenase reductase GPY31_RS19370 ENOG4107QR8 Thioredoxin GPY31_RS19375 ENOG4107QX8 SPFH domain, Band 7 family protein GPY31_RS19400 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GPY31_RS19405 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) GPY31_RS19410 ENOG4105EXN Sulfate transport protein CysZ GPY31_RS19415 ENOG4105C6T cysteine synthase GPY31_RS19425 ENOG4105KZ7 phosphocarrier protein hpr GPY31_RS19430 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GPY31_RS19435 ENOG4105C5Y PTS System GPY31_RS19450 ENOG4105I03 Flagellin GPY31_RS19460 ENOG4105I03 Flagellin GPY31_RS19470 ENOG4105DTJ flagellar hook-associated protein GPY31_RS19480 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GPY31_RS19485 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY31_RS19490 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY31_RS19495 ENOG4105CGA flagellar basal-body rod protein FlgG GPY31_RS19500 ENOG4108KPB Flagellar basal-body rod protein FlgF GPY31_RS19510 ENOG4105BZE flagellar hook protein, FlgE GPY31_RS19515 ENOG4105W00 Flagellar hook capping protein GPY31_RS19520 ENOG4108ZC9 flagellar basal-body rod protein flgc GPY31_RS19525 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GPY31_RS19530 ENOG4105BZU Histidine kinase GPY31_RS19535 ENOG4107R88 Chemotaxis protein (CheV) GPY31_RS19585 ENOG4105UYK outer membrane protein a GPY31_RS19595 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GPY31_RS19605 ENOG41081QG Porin Gram-negative type GPY31_RS19615 ENOG4105C59 p-type ATPase GPY31_RS19630 ENOG4105E2D ec 3.2.1.52 GPY31_RS19655 ENOG4108DG9 Smr protein MutS2 GPY31_RS19660 ENOG4105FE9 pseudouridine synthase GPY31_RS19665 ENOG4108Z66 YbaK ebsC protein GPY31_RS19670 ENOG4105CGH 5'-nucleotidase GPY31_RS19675 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GPY31_RS19680 ENOG41063JG Transcriptional regulator GPY31_RS19685 ENOG4108YY7 Invasion gene expression up-regulator SirB GPY31_RS19690 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GPY31_RS19695 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GPY31_RS19700 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GPY31_RS19705 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) GPY31_RS19710 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GPY31_RS19715 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GPY31_RS19720 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GPY31_RS19725 ENOG4105C3G gtp-binding protein GPY31_RS19840 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPY31_RS19850 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GPY31_RS19855 ENOG4105C9A Phoh family GPY31_RS19860 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GPY31_RS19865 ENOG4108JU5 Magnesium and cobalt efflux protein GPY31_RS19870 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GPY31_RS19875 ENOG4107PAI alpha helical protein GPY31_RS19880 ENOG4105C8T Leucyl-tRNA synthetase GPY31_RS19885 ENOG4108U2H Rare lipoprotein B GPY31_RS19890 ENOG4105DJF DNA polymerase III, delta' subunit GPY31_RS19895 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GPY31_RS19900 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GPY31_RS19905 ENOG4105CJN penicillin-binding protein GPY31_RS19910 ENOG4105CNI cell division protein FtsW GPY31_RS19915 ENOG4105K6T rare lipoprotein A GPY31_RS19920 ENOG4105DZ1 carboxypeptidase GPY31_RS19925 ENOG4108Z43 UPF0250 protein GPY31_RS19930 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GPY31_RS19935 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GPY31_RS19940 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GPY31_RS19945 ENOG4108JYZ YitT family GPY31_RS19960 ENOG4105CG3 alpha amylase, catalytic region GPY31_RS19965 ENOG4105C5Y PTS System GPY31_RS19970 ENOG4105D4X repressor GPY31_RS19975 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GPY31_RS19985 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS19990 ENOG4108UMI ABC transporter, permease GPY31_RS19995 ENOG4105D01 (LipO)protein GPY31_RS20000 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein GPY31_RS20005 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) GPY31_RS20010 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GPY31_RS20020 ENOG4105BZU Histidine kinase GPY31_RS20025 ENOG4105EWT decarboxylase family GPY31_RS20030 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease GPY31_RS20040 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) GPY31_RS20045 ENOG4105M08 Membrane GPY31_RS20055 ENOG4105ETT transcriptional Regulator, LysR family GPY31_RS20060 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GPY31_RS20065 ENOG4107QKZ Ompa motb domain protein GPY31_RS20070 ENOG4105E14 MotA TolQ exbB proton channel GPY31_RS20075 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GPY31_RS20080 ENOG4105CTB Polyprenyl synthetase GPY31_RS20085 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GPY31_RS20090 ENOG4108ZAI phosphatidylglycerophosphatase a GPY31_RS20095 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GPY31_RS20100 ENOG4107YIM Involved in the transcription termination process (By similarity) GPY31_RS20105 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GPY31_RS20120 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GPY31_RS20125 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GPY31_RS20130 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GPY31_RS20135 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GPY31_RS20140 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) GPY31_RS20145 ENOG4108DJV Fermentation respiration switch protein GPY31_RS20150 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GPY31_RS20155 ENOG4105C7N Xanthine uracil vitamin C permease GPY31_RS20160 ENOG4105CIN aminoacyl-histidine dipeptidase GPY31_RS20185 ENOG4108ETH Formylglycinamide ribotide synthetase GPY31_RS20190 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GPY31_RS20200 ENOG4108Z6B deaminase GPY31_RS20205 ENOG4105CFC Transporter GPY31_RS20240 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GPY31_RS20245 ENOG4105CFG Acts as a chaperone (By similarity) GPY31_RS20255 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GPY31_RS20260 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GPY31_RS20270 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GPY31_RS20275 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY31_RS20280 ENOG4105VDB UPF0125 protein GPY31_RS20285 ENOG4108Z1B Cyclase dehydrase GPY31_RS20290 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GPY31_RS20300 ENOG4105DFP Integrase GPY31_RS20310 ENOG4105DZR Type I site-specific deoxyribonuclease GPY31_RS20325 ENOG4105CVR type I restriction-modification system GPY31_RS20345 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY31_RS20350 ENOG4108YGG dna repair protein GPY31_RS20395 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY31_RS20435 ENOG4105ETT transcriptional Regulator, LysR family GPY31_RS20440 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GPY31_RS20460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GPY31_RS20465 ENOG4108IQK o-acetylhomoserine GPY31_RS20495 ENOG4105MWK D-amino acid dehydrogenase, small subunit GPY31_RS20500 ENOG4105BZG amino acid carrier protein GPY31_RS20510 ENOG4106HK8 GPR1 FUN34 yaaH family protein GPY31_RS20520 ENOG4107S6Z Na H antiporter GPY31_RS20525 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GPY31_RS20530 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY31_RS20535 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GPY31_RS20550 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GPY31_RS20555 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY31_RS20560 ENOG4105N21 Membrane GPY31_RS20565 ENOG4105CUT histidyl-tRNA synthetase GPY31_RS20570 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GPY31_RS20585 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GPY31_RS20590 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GPY31_RS20595 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPY31_RS20600 ENOG4105WVQ Fe-S assembly protein IscX GPY31_RS20605 ENOG4108ZIT Ferredoxin, 2FE-2S GPY31_RS20610 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GPY31_RS20615 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) GPY31_RS20620 ENOG4108Z4V iron-sulfur cluster assembly GPY31_RS20625 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GPY31_RS20630 ENOG4105C3J Cysteine desulfurase GPY31_RS20635 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GPY31_RS20640 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GPY31_RS20645 ENOG4105ECY inositol monophosphatase GPY31_RS20655 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY31_RS20660 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY31_RS20665 ENOG4105VIE preprotein translocase, subunit YajC GPY31_RS20670 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GPY31_RS20675 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GPY31_RS20685 ENOG4105W87 Cbs domain GPY31_RS20690 ENOG4108I9X Isocitrate lyase GPY31_RS20695 ENOG4107QP3 malate synthase g GPY31_RS20705 ENOG4105C5Q Transcriptional regulator GPY31_RS20710 ENOG4105D3R alkyl hydroperoxide reductase GPY31_RS20715 ENOG4106N3A copper homeostasis protein cutc GPY31_RS20720 ENOG4105CSR polyphosphate kinase 2 GPY31_RS20730 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GPY31_RS20735 ENOG4105E2Z phosphate ABC transporter (Permease GPY31_RS20740 ENOG4105C8U phosphate abc transporter GPY31_RS20745 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GPY31_RS20750 ENOG4105C9X ppx gppa phosphatase GPY31_RS20760 ENOG4105BZU Histidine kinase GPY31_RS20765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY31_RS20770 ENOG4105DH7 May be involved in recombination (By similarity) GPY31_RS20775 ENOG4105CFP Peptidase U32 GPY31_RS20780 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GPY31_RS20840 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY31_RS20845 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GPY31_RS20850 ENOG4105C34 Pseudouridine synthase GPY31_RS20855 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GPY31_RS20860 ENOG4105E4C Lytic transglycosylase catalytic GPY31_RS20865 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GPY31_RS20875 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GPY31_RS20880 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GPY31_RS20885 ENOG4107SC1 transglycosylase GPY31_RS20890 ENOG4105C5H ABC transporter GPY31_RS20905 ENOG4105DR5 peptidase GPY31_RS20910 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GPY31_RS20915 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY31_RS20920 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GPY31_RS20925 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GPY31_RS20930 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GPY31_RS20950 ENOG4108HRK Histidine kinase GPY31_RS20955 ENOG4108NEV two component transcriptional regulator, LytTR family GPY31_RS20960 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GPY31_RS20965 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GPY31_RS20970 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GPY31_RS20975 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GPY31_RS20980 ENOG4105DTN riboflavin biosynthesis protein ribF GPY31_RS20985 ENOG4105CJR Integral membrane protein (MviN GPY31_RS20990 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GPY31_RS21000 ENOG41080HT Transcriptional regulator, arsr family GPY31_RS21010 ENOG41063Z6 transcriptional regulator, lysR family GPY31_RS21025 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GPY31_RS21030 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GPY31_RS21035 ENOG4105HF0 Membrane GPY31_RS21040 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GPY31_RS21045 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GPY31_RS21055 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) GPY31_RS21075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS21080 ENOG4105CRK lysyL-tRNA synthetase GPY31_RS21090 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GPY31_RS21095 ENOG4105T95 Thiol disulfide interChange protein GPY31_RS21100 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY31_RS21105 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GPY31_RS21110 ENOG4105CWM branched-chain amino acid transport system II carrier protein GPY31_RS21115 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GPY31_RS21120 ENOG4105C1J atp-dependent rna helicase GPY31_RS21125 ENOG4105D1Q UPF0246 protein GPY31_RS21130 ENOG4105BZG amino acid carrier protein GPY31_RS21145 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GPY31_RS21155 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GPY31_RS21160 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) GPY31_RS21165 ENOG4105D98 threonine synthase GPY31_RS21170 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GPY31_RS21185 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GPY31_RS21200 ENOG41065U4 response regulator GPY31_RS21210 ENOG4105BZU Histidine kinase GPY31_RS21220 ENOG4105N5T Radical SAM Protein GPY31_RS21235 ENOG4105CBC glutamate synthase GPY31_RS21240 ENOG4105BZ8 glutamate synthase GPY31_RS21250 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GPY31_RS21255 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GPY31_RS21260 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GPY31_RS21265 ENOG4105EN6 Membrane GPY31_RS21270 ENOG4105VP0 transcriptional regulator, lysR family GPY31_RS21275 ENOG4105EJ9 Membrane GPY31_RS21290 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GPY31_RS21295 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GPY31_RS21300 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GPY31_RS21305 ENOG4105M6F mutator MutT protein GPY31_RS21310 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GPY31_RS21320 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY31_RS21325 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GPY31_RS21330 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GPY31_RS21335 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GPY31_RS21340 ENOG4105DFU Cell wall formation (By similarity) GPY31_RS21345 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GPY31_RS21355 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GPY31_RS21360 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GPY31_RS21365 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GPY31_RS21370 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GPY31_RS21375 ENOG4105CJN penicillin-binding protein GPY31_RS21380 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GPY31_RS21385 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GPY31_RS21400 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GPY31_RS21410 ENOG41082RQ UPF0102 protein GPY31_RS21415 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GPY31_RS21420 ENOG4105W4M Transport-associated protein GPY31_RS21425 ENOG4105KB2 stringent starvation protein b GPY31_RS21430 ENOG4107MKT Stringent starvation protein a GPY31_RS21435 ENOG4105EIX cytochrome c1 GPY31_RS21440 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPY31_RS21445 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPY31_RS21450 ENOG4108UJD 30S ribosomal protein S9 GPY31_RS21455 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GPY31_RS21465 ENOG4105D6Z AFG1 family ATPase GPY31_RS21475 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GPY31_RS21480 ENOG4105C0H protease GPY31_RS21485 ENOG4105C0H protease GPY31_RS21490 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY31_RS21495 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY31_RS21500 ENOG4105IPS esterase GPY31_RS21505 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GPY31_RS21510 ENOG4108SX3 cytoplasmic protein GPY31_RS21515 ENOG41087AY ADP-Ribose pyrophosphatase GPY31_RS21520 ENOG4105DFG type I secretion outer membrane protein GPY31_RS21525 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GPY31_RS21530 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GPY31_RS21535 ENOG4108NVR Methyl-accepting chemotaxis GPY31_RS21545 ENOG4105I7R Adenylate cyclase GPY31_RS21550 ENOG4107IX6 phosphate transport regulator GPY31_RS21555 ENOG4105CJ3 phosphate transporter GPY31_RS21560 ENOG4106MWK domain protein GPY31_RS21575 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GPY31_RS21580 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GPY31_RS21585 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPY31_RS21590 ENOG4107ZVW dihydroneopterin aldolase GPY31_RS21595 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GPY31_RS21600 ENOG4108WC5 Alpha Beta Hydrolase Fold protein GPY31_RS21605 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY31_RS21610 ENOG4105VCC 30S ribosomal protein S21 GPY31_RS21615 ENOG4105KTH gatB Yqey GPY31_RS21620 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GPY31_RS21625 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY31_RS21635 ENOG4105D01 (LipO)protein GPY31_RS21670 ENOG4105CTS PTS system mannitol-specific GPY31_RS21675 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GPY31_RS21680 ENOG4105E61 Mannitol repressor protein GPY31_RS21695 ENOG4108UTZ Dihydroxyacetone kinase GPY31_RS21700 ENOG4105CMT Dihydroxyacetone kinase GPY31_RS21710 ENOG4105GR3 Histidine kinase GPY31_RS21725 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GPY31_RS21730 ENOG410804X Transcriptional regulator GPY31_RS21740 ENOG4105CA9 Pyruvate kinase GPY31_RS21750 ENOG4105BZU Histidine kinase GPY31_RS21755 ENOG4108ZP8 Acetolactate synthase small subunit GPY31_RS21760 ENOG4105C7K acetolactate synthase GPY31_RS21765 ENOG4108IQE Amp-dependent synthetase and ligase GPY31_RS21770 ENOG41064T2 transcriptional regulator, lysR family GPY31_RS21790 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GPY31_RS21795 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GPY31_RS21800 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GPY31_RS21805 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GPY31_RS21815 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GPY31_RS21820 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GPY31_RS21825 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) GPY31_RS21830 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GPY31_RS21835 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GPY31_RS21840 ENOG4105NWN ApaG protein GPY31_RS21845 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GPY31_RS21850 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GPY31_RS21860 ENOG4105DWK Membrane GPY31_RS21865 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GPY31_RS21870 ENOG4105K46 50S ribosomal protein l27 GPY31_RS21875 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GPY31_RS21880 ENOG4105EAH synthase GPY31_RS21890 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GPY31_RS21895 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) GPY31_RS21925 ENOG4107T0D ABC, transporter GPY31_RS21930 ENOG4106SMU thiamine transporter membrane protein GPY31_RS21935 ENOG4105DP9 ABC transporter GPY31_RS21940 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GPY31_RS21945 ENOG4105DFU Cell wall formation (By similarity) GPY31_RS21955 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 GPY31_RS21960 ENOG4105F0N pyrophosphate phospho-hydrolase GPY31_RS21970 ENOG41066HZ AIG2-like family GPY31_RS21975 ENOG4105MA0 exported protein GPY31_RS21985 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GPY31_RS21990 ENOG41061GZ Protein of unknown function (DUF1107) GPY31_RS21995 ENOG4108UUE Transcriptional regulator GPY31_RS22010 ENOG4108I0Y (ABC) transporter GPY31_RS22030 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GPY31_RS22045 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) GPY31_RS22050 ENOG4105C11 sulfate adenylyltransferase), subunit 2 GPY31_RS22055 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPY31_RS22060 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GPY31_RS22070 ENOG4105C1J atp-dependent rna helicase GPY31_RS22075 ENOG4107YB6 acetyltransferase, (GNAT) family GPY31_RS22085 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY31_RS22095 ENOG4108ZT0 50S ribosomal protein l17 GPY31_RS22100 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY31_RS22105 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GPY31_RS22110 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GPY31_RS22115 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GPY31_RS22125 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GPY31_RS22130 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GPY31_RS22135 ENOG4105VPB 50S ribosomal protein L30 GPY31_RS22140 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GPY31_RS22150 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GPY31_RS22155 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GPY31_RS22160 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GPY31_RS22165 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GPY31_RS22170 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GPY31_RS22175 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GPY31_RS22180 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GPY31_RS22185 ENOG41083MP 50s ribosomal protein l29 GPY31_RS22190 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GPY31_RS22195 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GPY31_RS22200 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GPY31_RS22205 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GPY31_RS22210 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GPY31_RS22215 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GPY31_RS22220 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GPY31_RS22225 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GPY31_RS22230 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GPY31_RS22235 ENOG4105VFB Binds the 23S rRNA (By similarity) GPY31_RS22245 ENOG4105C25 Primosomal protein n' GPY31_RS22250 ENOG4105ETE Transcriptional regulator (LacI family GPY31_RS22260 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GPY31_RS22265 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GPY31_RS22270 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GPY31_RS22275 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GPY31_RS22280 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) GPY31_RS22290 ENOG4105CBT Fructose-1,6-bisphosphatase GPY31_RS22315 ENOG4105CP7 Triose-phosphate isomerase GPY31_RS22320 ENOG4105CY0 Metallo-Beta-Lactamase GPY31_RS22335 ENOG4105D3Q Sugar transferase GPY31_RS22350 ENOG4105EIP mannose-6-phosphate isomerase GPY31_RS22355 ENOG4106ECQ phosphomannomutase GPY31_RS22360 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GPY31_RS22365 ENOG4105FGF GDP-mannose mannosyl hydrolase GPY31_RS22370 ENOG4105C30 Nad-dependent epimerase dehydratase GPY31_RS22375 ENOG4105C0K Gdp-mannose 4,6-dehydratase GPY31_RS22395 ENOG4105E2K Glycosyl transferase (Group 1 GPY31_RS22405 ENOG4105ECJ Glycosyl Transferase GPY31_RS22410 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GPY31_RS22420 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GPY31_RS22455 ENOG4105E3R (LipO)protein GPY31_RS22460 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GPY31_RS22465 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GPY31_RS22475 ENOG4105XA0 heptosyltransferase ii GPY31_RS22485 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GPY31_RS22545 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GPY31_RS22550 ENOG4105C1B dTDP-glucose 4-6-dehydratase GPY31_RS22555 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) GPY31_RS22560 ENOG41080IJ Diacylglycerol kinase GPY31_RS22565 ENOG4105DKP glycosyl transferase, family 9 GPY31_RS22570 ENOG4106WTF Glycosyl transferase, family 2 GPY31_RS22580 ENOG4108JMC lipopolysaccharide core biosynthesis protein GPY31_RS22585 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GPY31_RS22590 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GPY31_RS22600 ENOG4108I6E Sulfatase GPY31_RS22610 ENOG4105KDC 50s ribosomal protein l28 GPY31_RS22615 ENOG4105W5Q DNA repair protein (RadC GPY31_RS22620 ENOG4105C8Q Methyl-accepting chemotaxis GPY31_RS22630 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GPY31_RS22635 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GPY31_RS22640 ENOG4105D1S lipid A biosynthesis GPY31_RS22645 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GPY31_RS22650 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GPY31_RS22655 ENOG4105DSJ YicC domain protein GPY31_RS22665 ENOG4108JQ7 (ABC) transporter GPY31_RS22675 ENOG4107QRA Extracellular solute-binding protein, family 5 GPY31_RS22680 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GPY31_RS22685 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GPY31_RS22695 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) GPY31_RS22715 ENOG4109015 Biopolymer transport protein exbD tolR GPY31_RS22730 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GPY31_RS22735 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GPY31_RS22740 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPY31_RS22745 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GPY31_RS22750 ENOG4105CB5 ATP-dependent DNA helicase recG GPY31_RS22755 ENOG4105C2W permease GPY31_RS22765 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY31_RS22775 ENOG4108RRZ Transcription elongation factor GreB GPY31_RS22785 ENOG4105BZM domain protein GPY31_RS22795 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GPY31_RS22800 ENOG4105MJ2 Competence protein GPY31_RS22805 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) GPY31_RS22810 ENOG4107RK2 ADP-ribose diphosphatase NudE GPY31_RS22815 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GPY31_RS22820 ENOG4105PIC general secretion pathway protein N GPY31_RS22825 ENOG4105U1E general secretion pathway protein M GPY31_RS22830 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) GPY31_RS22835 ENOG4108RTD type II secretion system protein K GPY31_RS22840 ENOG4108WWZ General secretion pathway protein J GPY31_RS22845 ENOG4105X5Z General secretion pathway protein I GPY31_RS22850 ENOG4105VWV general secretion pathway protein h GPY31_RS22855 ENOG4108VAU general secretion pathway protein G GPY31_RS22860 ENOG4105D7Q type ii secretion system GPY31_RS22865 ENOG4107QHF type ii secretion system protein e GPY31_RS22875 ENOG4108XKW General secretion pathway protein C GPY31_RS22880 ENOG4105VEJ Heat shock protein GPY31_RS22885 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GPY31_RS22890 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GPY31_RS22900 ENOG4105SUU thioesterase domain GPY31_RS22905 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GPY31_RS22910 ENOG4107S2Z UPF0761 membrane protein GPY31_RS22930 ENOG4105C5F glutamine synthetase GPY31_RS22940 ENOG4105CUX Signal transduction histidine kinase GPY31_RS22945 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS22950 ENOG4105BZU Histidine kinase GPY31_RS22955 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GPY31_RS22960 ENOG4105D4P Coproporphyrinogen iii oxidase GPY31_RS22965 ENOG4105XCT Protein of unknown function (DUF2489) GPY31_RS22970 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) GPY31_RS22985 ENOG4106RE7 Cytochrome GPY31_RS22990 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GPY31_RS23000 ENOG4105C2M dna polymerase I GPY31_RS23015 ENOG4105D52 delta-aminolevulinic acid dehydratase GPY31_RS23025 ENOG4105F8V Hydrolase, tatD family GPY31_RS23035 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GPY31_RS23040 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GPY31_RS23045 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GPY31_RS23050 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GPY31_RS23055 ENOG4105JC1 sterol-binding domain protein GPY31_RS23060 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GPY31_RS23065 ENOG4105CGY Dna recombination protein GPY31_RS23075 ENOG4105BZU Histidine kinase GPY31_RS23080 ENOG4105DSF transport protein GPY31_RS23110 ENOG4107TE5 Lipid kinase GPY31_RS23130 ENOG4105K3G Periplasmic Protein GPY31_RS23135 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY31_RS23140 ENOG4105CBX hi0933 family GPY31_RS23145 ENOG4108V6B universal stress protein B GPY31_RS23150 ENOG41090A1 ferritin GPY31_RS23155 ENOG4108M6U Universal stress protein A GPY31_RS23160 ENOG4105EMK carboxylate amino acid amine transporter GPY31_RS23170 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) GPY31_RS23175 ENOG4105BZU Histidine kinase GPY31_RS23180 ENOG4108VVK transcriptional Regulator, AsnC GPY31_RS23185 ENOG4105DGW oligopeptidase A GPY31_RS23190 ENOG4105D6S protein involved in catabolism of external DNA GPY31_RS23195 ENOG4105DC8 reductase GPY31_RS23200 ENOG4107RSM transcriptional regulator GPY31_RS23205 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) GPY31_RS23210 ENOG4108UHU Aldolase GPY31_RS23215 ENOG4105C6Z Gluconate GPY31_RS23220 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GPY31_RS23225 ENOG4105C01 Dihydroxy-acid dehydratase GPY31_RS23230 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) GPY31_RS23235 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) GPY31_RS23240 ENOG41064T2 transcriptional regulator, lysR family GPY31_RS23245 ENOG4105DIQ Transcriptional regulator GPY31_RS23250 ENOG4105D9P serine threonine protein kinase GPY31_RS23285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY31_RS23290 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY31_RS23295 ENOG4105DEF Extracellular solute-binding protein, family 5 GPY31_RS23300 ENOG4108JQ6 ABC transporter GPY31_RS23350 ENOG4105MPD Cytochrome GPY31_RS23355 ENOG4105C4R Atp-dependent dna helicase GPY31_RS23360 ENOG41067SE Tetr family transcriptional regulator GPY31_RS23365 ENOG410624X efflux transporter, rnd family, mfp subunit GPY31_RS23370 ENOG4105BZS acriflavin resistance protein GPY31_RS23380 ENOG4105W0Z cytoplasmic protein GPY31_RS23385 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GPY31_RS23390 ENOG4105EMY transcriptional regulator GPY31_RS23430 ENOG4108Z0R Transferase GPY31_RS23435 ENOG4105SG3 Protein of unknown function (DUF1488) GPY31_RS23440 ENOG4105E2X shikimate dehydrogenase GPY31_RS23445 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) GPY31_RS23450 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY31_RS23455 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GPY31_RS23460 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GPY31_RS23465 ENOG4108WI1 Dna topoisomerase GPY31_RS23470 ENOG4108RPN Protein smg homolog GPY31_RS23475 ENOG4105C79 DNA protecting protein DprA GPY31_RS23485 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GPY31_RS23490 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GPY31_RS23495 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GPY31_RS23500 ENOG4105C1A potassium transporter peripheral membrane GPY31_RS23505 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPY31_RS23515 ENOG4108UT2 hemolysin iii GPY31_RS23520 ENOG4108N23 SpoOM-related protein GPY31_RS23530 ENOG4105PC1 Conserved Protein GPY31_RS23540 ENOG4105E27 serine threonine protein kinase GPY31_RS23545 ENOG4108Z33 Thiol disulfide Interchange Protein GPY31_RS23550 ENOG4106HNH Acyl-transferase GPY31_RS23560 ENOG4105C0P Mg chelatase subunit ChlI GPY31_RS23580 ENOG4105C79 DNA protecting protein DprA GPY31_RS23605 ENOG4107TII Recombinase GPY31_RS23610 ENOG4105C0P Mg chelatase subunit ChlI GPY31_RS23620 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GPY31_RS23625 ENOG4105CM2 brancheD-chain amino acid aminotransferase GPY31_RS23630 ENOG4105C01 Dihydroxy-acid dehydratase GPY31_RS23635 ENOG4105C7B Threonine dehydratase GPY31_RS23640 ENOG4105F52 Transcriptional regulator GPY31_RS23645 ENOG4105CZQ inner membrane transport protein YdhC GPY31_RS23655 ENOG4105EAD ABC transporter GPY31_RS23660 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GPY31_RS23665 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GPY31_RS23670 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GPY31_RS23675 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GPY31_RS23680 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GPY31_RS23685 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY31_RS23690 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY31_RS23695 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY31_RS23700 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) GPY31_RS23705 ENOG410684E atp synthase GPY31_RS23710 ENOG4105FA0 parb-like partition protein GPY31_RS23715 ENOG4107QJE Chromosome Partitioning Protein GPY31_RS23720 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GPY31_RS23725 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GPY31_RS23730 ENOG4105QTB Flavodoxin GPY31_RS23735 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GPY31_RS23740 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GPY31_RS23745 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GPY31_RS23750 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GPY31_RS23765 ENOG4105E5Q amino acid AbC transporter GPY31_RS23770 ENOG4105EAB amino acid AbC transporter GPY31_RS23785 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GPY31_RS23790 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GPY31_RS23795 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GPY31_RS23800 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY31_RS23820 ENOG4108ZNX Heat shock protein GPY31_RS23825 ENOG4105JKW Valine--pyruvate aminotransferase GPY31_RS23830 ENOG4107T9C Alpha amylase catalytic region GPY31_RS23835 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GPY31_RS23840 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GPY31_RS23855 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) GPY31_RS23870 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GPY31_RS23875 ENOG4105CHU acetyl-coa acetyltransferase GPY31_RS23880 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GPY31_RS23885 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GPY31_RS23890 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPY31_RS23895 ENOG4108RR8 protoporphyrinogen oxidase GPY31_RS23945 ENOG4105WMR Protein CrcB homolog GPY31_RS23950 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GPY31_RS23955 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GPY31_RS23960 ENOG4105D06 uba thif-type nad fad binding protein GPY31_RS23965 ENOG4105WHD thiamine biosynthesis protein ThiS GPY31_RS23970 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GPY31_RS23975 ENOG4105D41 biosynthesis protein thiH GPY31_RS23980 ENOG4105DC7 peptidase M24 GPY31_RS23980 ENOG4105DC7 peptidase M24 GPY31_RS24010 ENOG4105E18 UPF0276 protein GPY31_RS24020 ENOG4105C4R Atp-dependent dna helicase GPY31_RS24030 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GPY31_RS24045 ENOG4105FR1 rard protein GPY31_RS24050 ENOG4105C9U ATP-dependent DNA helicase RecQ GPY31_RS24065 ENOG4105EX9 Membrane GPY31_RS24070 ENOG4105C9X ppx gppa phosphatase GPY31_RS24075 ENOG4105C1J atp-dependent rna helicase GPY31_RS24080 ENOG4105K63 Thioredoxin GPY31_RS24085 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GPY31_RS24100 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GPY31_RS24105 ENOG4108ZIT Ferredoxin, 2FE-2S GPY31_RS24110 ENOG4107QK7 reductase GPY31_RS24160 ENOG410601J HemY protein GPY31_RS24165 ENOG4105ECF c-methyltransferase GPY31_RS24170 ENOG41076E6 Uroporphyrinogen-III Synthase GPY31_RS24175 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GPY31_RS24180 ENOG4107T0K Adenylate cyclase GPY31_RS24185 ENOG4105XQ6 frataxin-like protein GPY31_RS24195 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GPY31_RS24200 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GPY31_RS24210 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY31_RS24215 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GPY31_RS24220 ENOG4105BZU Histidine kinase GPY31_RS24225 ENOG4106IUH DTW domain containing protein GPY31_RS24240 ENOG4105DQF Hydrolase GPY31_RS24245 ENOG4108EUD Lysophospholipase GPY31_RS24250 ENOG410829K Lysine exporter protein (Lyse ygga) GPY31_RS24255 ENOG4105D58 Diguanylate phosphodiesterase GPY31_RS24260 ENOG41082YX Transcriptional regulator, arsr family GPY31_RS24265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY31_RS24320 ENOG41076UM multiple antibiotic resistance (MarC)-related protein GPY31_RS24330 ENOG4106H78 methyltransferase GPY31_RS24335 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GPY31_RS24340 ENOG4105CAK Cell division ATP-binding protein ftsE GPY31_RS24345 ENOG4105CRP Part of the ABC transporter FtsEX involved in GPY31_RS24350 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY31_RS24355 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GPY31_RS24360 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) GPY31_RS24365 ENOG4105X6C Flagellar basal body-associated protein FliL GPY31_RS24370 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GPY31_RS24375 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GPY31_RS24380 ENOG4105E55 glycerol-3-phosphate acyltransferase GPY31_RS24390 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GPY31_RS24400 ENOG4107R73 Mate efflux family protein GPY31_RS24405 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GPY31_RS24420 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) GPY31_RS24425 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) GPY31_RS24435 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GPY31_RS24495 ENOG4105JIM Phosphatidylserine synthase GPY31_RS24505 ENOG4105D4A Cell wall formation (By similarity) GPY31_RS24510 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GPY31_RS24515 ENOG4105CS9 pantothenic acid kinase GPY31_RS24540 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GPY31_RS24550 ENOG4105PM1 preprotein translocase subunit SecE GPY31_RS24555 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GPY31_RS24560 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GPY31_RS24565 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GPY31_RS24570 ENOG4108VZM 50s ribosomal protein L10 GPY31_RS24575 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GPY31_RS24580 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY31_RS24585 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY31_RS24590 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor GPY31_RS24595 ENOG4105E09 nadh pyrophosphatase GPY31_RS24610 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GPY31_RS24615 ENOG4108RG0 uracil-dna glycosylase GPY31_RS24620 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GPY31_RS24625 ENOG4105R2J Conserved Protein GPY31_RS24645 ENOG4105C12 Phosphoribosylglycinamide synthetase GPY31_RS24655 ENOG4105DC1 bifunctional purine biosynthesis protein purh GPY31_RS24665 ENOG4105W1Y Transcriptional regulator GPY31_RS24670 ENOG4108M3R transcriptional activator CadC GPY31_RS24680 ENOG4105D5Q Arginine ornithine antiporter GPY31_RS24685 ENOG4105CXN decarboxylase