locus-tag	class	description
AL464_RS00010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_RS00020	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL464_RS00020	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL464_RS00025	COG1706	bacterial-type flagellum-dependent cell motility
AL464_RS00030	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL464_RS00040	COG4787	bacterial-type flagellum-dependent cell motility
AL464_RS00045	COG1749	Flagellar hook protein flgE
AL464_RS00055	COG1558	bacterial-type flagellum-dependent cell motility
AL464_RS00060	COG1815	bacterial-type flagellum-dependent cell motility
AL464_RS00065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL464_RS00070	COG0835	chemotaxis
AL464_RS00070	COG0784	Response regulator, receiver
AL464_RS00120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL464_RS00125	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL464_RS00135	COG2217	Heavy metal translocating P-type atpase
AL464_RS00135	COG2608	mercury ion transmembrane transporter activity
AL464_RS00165	COG2840	Smr protein MutS2
AL464_RS00170	COG1187	pseudouridine synthase activity
AL464_RS00180	COG0737	Belongs to the 5'-nucleotidase family
AL464_RS00185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL464_RS00190	COG2912	Transglutaminase-like superfamily
AL464_RS00195	COG3094	Invasion gene expression up-regulator, SirB
AL464_RS00200	COG2890	protein-(glutamine-N5) methyltransferase activity
AL464_RS00205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL464_RS00210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL464_RS00215	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL464_RS00220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL464_RS00225	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL464_RS00230	COG0193	aminoacyl-tRNA hydrolase activity
AL464_RS00235	COG0012	GTP binding
AL464_RS00350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL464_RS00355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL464_RS00360	COG1702	phosphate starvation-inducible protein PhoH
AL464_RS00365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL464_RS00370	COG4535	Mg2 and Co2 transporter CorC
AL464_RS00375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL464_RS00380	COG2888	peptidyl-tyrosine sulfation
AL464_RS00385	COG0495	leucyl-tRNA aminoacylation
AL464_RS00390	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL464_RS00395	COG1466	dna polymerase III delta subunit
AL464_RS00400	COG0799	negative regulation of ribosome biogenesis
AL464_RS00405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL464_RS00410	COG0768	penicillin binding
AL464_RS00415	COG0772	Belongs to the SEDS family
AL464_RS00420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL464_RS00425	COG1686	Belongs to the peptidase S11 family
AL464_RS00430	COG2921	Belongs to the UPF0250 family
AL464_RS00435	COG0321	lipoyl(octanoyl) transferase activity
AL464_RS00440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL464_RS00445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL464_RS00450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL464_RS00465	COG0366	Alpha amylase catalytic
AL464_RS00470	COG1263	PTS System
AL464_RS00470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL464_RS00480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL464_RS00485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL464_RS00490	COG2011	ABC-type metal ion transport system permease component
AL464_RS00495	COG1464	Belongs to the NlpA lipoprotein family
AL464_RS00500	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL464_RS00510	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL464_RS00510	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL464_RS00525	COG1611	Belongs to the LOG family
AL464_RS00530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL464_RS00540	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AL464_RS00545	COG2363	Small membrane protein
AL464_RS00555	COG0583	DNA-binding transcription factor activity
AL464_RS00560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL464_RS00560	COG0301	tRNA thio-modification
AL464_RS00565	COG2885	chlorophyll binding
AL464_RS00570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL464_RS00575	COG1722	exodeoxyribonuclease VII activity
AL464_RS00580	COG0142	geranyltranstransferase activity
AL464_RS00585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL464_RS00590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL464_RS00595	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL464_RS00600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL464_RS00620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL464_RS00620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL464_RS00625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL464_RS00630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL464_RS00635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL464_RS00645	COG1073	alpha beta
AL464_RS00650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL464_RS00655	COG2252	PERMEase
AL464_RS00660	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL464_RS00685	COG0047	phosphoribosylformylglycinamidine synthase activity
AL464_RS00685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL464_RS00690	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL464_RS00700	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL464_RS00720	COG4969	Belongs to the N-Me-Phe pilin family
AL464_RS00730	COG0484	heat shock protein binding
AL464_RS00735	COG0443	Heat shock 70 kDa protein
AL464_RS00745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL464_RS00750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL464_RS00760	COG0497	DNA recombination
AL464_RS00765	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL464_RS00770	COG2914	Belongs to the UPF0125 (RnfH) family
AL464_RS00775	COG2867	negative regulation of translational initiation
AL464_RS00780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL464_RS00830	COG0583	DNA-binding transcription factor activity
AL464_RS00835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL464_RS00835	COG3153	acetyltransferase
AL464_RS00855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL464_RS00860	COG2873	o-acetylhomoserine
AL464_RS00900	COG1584	GPR1 FUN34 yaaH family protein
AL464_RS00910	COG1757	Na H antiporter
AL464_RS00915	COG0519	Catalyzes the synthesis of GMP from XMP
AL464_RS00915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL464_RS00920	COG0517	IMP dehydrogenase activity
AL464_RS00920	COG0516	GMP reductase activity
AL464_RS00925	COG1570	exodeoxyribonuclease VII activity
AL464_RS00940	COG1160	GTP binding
AL464_RS00945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL464_RS00950	COG2976	Protein conserved in bacteria
AL464_RS00955	COG0124	histidyl-tRNA synthetase
AL464_RS00960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL464_RS00970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL464_RS00975	COG0105	UTP biosynthetic process
AL464_RS00980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL464_RS00985	COG2975	iron-sulfur cluster assembly
AL464_RS00990	COG0633	Ferredoxin
AL464_RS00995	COG0443	Heat shock 70 kDa protein
AL464_RS01000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL464_RS01010	COG0822	iron-sulfur transferase activity
AL464_RS01015	COG1104	cysteine desulfurase activity
AL464_RS01030	COG0483	inositol monophosphate 1-phosphatase activity
AL464_RS01035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL464_RS01040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL464_RS01045	COG1862	Preprotein translocase
AL464_RS01050	COG0343	queuine tRNA-ribosyltransferase activity
AL464_RS01055	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL464_RS01065	COG0517	IMP dehydrogenase activity
AL464_RS01075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL464_RS01080	COG0583	DNA-binding transcription factor activity
AL464_RS01085	COG0450	alkyl hydroperoxide reductase
AL464_RS01090	COG3142	Participates in the control of copper homeostasis
AL464_RS01100	COG0704	Plays a role in the regulation of phosphate uptake
AL464_RS01105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL464_RS01110	COG0581	inorganic phosphate transmembrane transporter activity
AL464_RS01120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL464_RS01125	COG0248	Ppx GppA phosphatase
AL464_RS01135	COG5002	protein histidine kinase activity
AL464_RS01140	COG0745	RESPONSE REGULATOR receiver
AL464_RS01145	COG2974	May be involved in recombination
AL464_RS01150	COG0826	peptidase U32
AL464_RS01155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL464_RS01210	COG0542	response to heat
AL464_RS01220	COG0564	pseudouridine synthase activity
AL464_RS01225	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL464_RS01230	COG0741	lytic transglycosylase activity
AL464_RS01235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL464_RS01240	COG1605	Chorismate mutase
AL464_RS01240	COG0077	Prephenate dehydratase
AL464_RS01245	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL464_RS01250	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL464_RS01260	COG0488	(ABC) transporter
AL464_RS01275	COG0739	heme binding
AL464_RS01280	COG1605	Chorismate mutase
AL464_RS01280	COG0287	Prephenate dehydrogenase
AL464_RS01285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL464_RS01290	COG1472	Belongs to the glycosyl hydrolase 3 family
AL464_RS01295	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL464_RS01300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL464_RS01315	COG1966	Carbon starvation protein
AL464_RS01320	COG3275	phosphorelay sensor kinase activity
AL464_RS01325	COG3279	Response regulator of the LytR AlgR family
AL464_RS01330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL464_RS01335	COG1047	Peptidyl-prolyl cis-trans
AL464_RS01340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL464_RS01345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL464_RS01350	COG0196	riboflavin kinase activity
AL464_RS01355	COG0728	peptidoglycan biosynthetic process
AL464_RS01360	COG0268	Binds directly to 16S ribosomal RNA
AL464_RS01365	COG0640	Transcriptional regulator
AL464_RS01370	COG0583	DNA-binding transcription factor activity
AL464_RS01375	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL464_RS01385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL464_RS01390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL464_RS01395	COG0730	response to heat
AL464_RS01405	COG0494	nUDIX hydrolase
AL464_RS01410	COG3066	DNA modification
AL464_RS01420	COG0667	Aldo Keto reductase
AL464_RS01430	COG2204	response regulator
AL464_RS01435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL464_RS01440	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AL464_RS01445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL464_RS01450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL464_RS01455	COG4974	Belongs to the 'phage' integrase family
AL464_RS01460	COG0716	FMN binding
AL464_RS01470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL464_RS01475	COG0513	Belongs to the DEAD box helicase family
AL464_RS01480	COG3022	response to hydroperoxide
AL464_RS01485	COG1115	amino acid carrier protein
AL464_RS01500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL464_RS01505	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL464_RS01510	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL464_RS01515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL464_RS01520	COG0083	homoserine kinase activity
AL464_RS01535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL464_RS01545	COG0745	RESPONSE REGULATOR receiver
AL464_RS01555	COG0784	Response regulator, receiver
AL464_RS01555	COG2198	Histidine kinase
AL464_RS01555	COG5002	protein histidine kinase activity
AL464_RS01560	COG5001	Diguanylate cyclase
AL464_RS01560	COG4251	negative regulation of phosphorylation
AL464_RS01560	COG3706	GGDEF domain
AL464_RS01560	COG2203	Gaf domain
AL464_RS01565	COG1242	4 iron, 4 sulfur cluster binding
AL464_RS01570	COG0067	glutamate synthase
AL464_RS01570	COG0069	glutamate synthase activity
AL464_RS01570	COG0070	glutamate synthase
AL464_RS01580	COG0067	glutamate synthase
AL464_RS01580	COG0069	glutamate synthase activity
AL464_RS01580	COG0070	glutamate synthase
AL464_RS01585	COG0493	'glutamate synthase
AL464_RS01595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL464_RS01605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL464_RS01610	COG2860	membrane
AL464_RS01615	COG0583	DNA-binding transcription factor activity
AL464_RS01620	COG0730	response to heat
AL464_RS01635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL464_RS01640	COG0505	Belongs to the CarA family
AL464_RS01645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL464_RS01650	COG0494	nUDIX hydrolase
AL464_RS01655	COG0653	protein targeting
AL464_RS01665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL464_RS01670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL464_RS01675	COG0849	cell division
AL464_RS01680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL464_RS01685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL464_RS01690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL464_RS01695	COG0772	Belongs to the SEDS family
AL464_RS01700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL464_RS01705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL464_RS01710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL464_RS01715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL464_RS01720	COG0768	penicillin binding
AL464_RS01725	COG3116	cell division
AL464_RS01730	COG0275	rRNA processing
AL464_RS01740	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL464_RS01750	COG0792	nuclease activity
AL464_RS01755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL464_RS01760	COG2823	Periplasmic or secreted lipoprotein
AL464_RS01765	COG2969	positive regulation of protein catabolic process
AL464_RS01770	COG0625	glutathione transferase activity
AL464_RS01775	COG2857	Cytochrome c1
AL464_RS01780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL464_RS01785	COG0723	plastoquinol--plastocyanin reductase activity
AL464_RS01790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL464_RS01795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL464_RS01800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL464_RS01805	COG3105	Protein conserved in bacteria
AL464_RS01815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL464_RS01820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL464_RS01840	COG3151	Protein conserved in bacteria
AL464_RS01845	COG0494	nUDIX hydrolase
AL464_RS01850	COG1538	Outer membrane efflux protein
AL464_RS01855	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL464_RS01855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL464_RS01860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL464_RS01875	COG3025	triphosphatase activity
AL464_RS01880	COG1392	Phosphate transport regulator
AL464_RS01885	COG0306	phosphate transporter
AL464_RS01890	COG4991	sh3 domain protein
AL464_RS01900	COG3409	Peptidoglycan-binding domain 1 protein
AL464_RS01900	COG3267	Type II secretory pathway component ExeA
AL464_RS01905	COG0617	tRNA 3'-terminal CCA addition
AL464_RS01910	COG1968	undecaprenyl-diphosphatase activity
AL464_RS01915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL464_RS01920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL464_RS01925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL464_RS01930	COG0596	Alpha beta hydrolase
AL464_RS01935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL464_RS01940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL464_RS01945	COG1610	YqeY-like protein
AL464_RS01950	COG0358	DNA primase activity
AL464_RS01965	COG1464	Belongs to the NlpA lipoprotein family
AL464_RS01995	COG2213	PTS system mannitol-specific
AL464_RS01995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_RS02000	COG0246	Mannitol dehydrogenase
AL464_RS02005	COG3722	fumarate hydratase activity
AL464_RS02010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL464_RS02015	COG5002	protein histidine kinase activity
AL464_RS02030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL464_RS02035	COG1349	DNA-binding transcription factor activity
AL464_RS02040	COG0469	pyruvate kinase activity
AL464_RS02055	COG0440	acetolactate synthase activity
AL464_RS02060	COG0028	Belongs to the TPP enzyme family
AL464_RS02065	COG1022	Amp-dependent synthetase and ligase
AL464_RS02070	COG0583	DNA-binding transcription factor activity
AL464_RS02095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL464_RS02100	COG0473	3-isopropylmalate dehydrogenase activity
AL464_RS02105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL464_RS02110	COG0066	3-isopropylmalate dehydratase activity
AL464_RS02120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL464_RS02125	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL464_RS02130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL464_RS02135	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL464_RS02140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL464_RS02145	COG2967	ApaG domain
AL464_RS02150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL464_RS02165	COG2966	Psort location CytoplasmicMembrane, score
AL464_RS02170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL464_RS02180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL464_RS02185	COG0142	geranyltranstransferase activity
AL464_RS02195	COG0039	L-malate dehydrogenase activity
AL464_RS02205	COG2358	TRAP transporter, solute receptor (TAXI family
AL464_RS02220	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL464_RS02225	COG1178	ABC-type Fe3 transport system permease component
AL464_RS02230	COG4143	(ABC) transporter
AL464_RS02235	COG0163	prenyltransferase activity
AL464_RS02240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL464_RS02245	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL464_RS02250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL464_RS02260	COG2105	PFAM AIG2 family protein
AL464_RS02265	COG2911	Protein conserved in bacteria
AL464_RS02270	COG0729	surface antigen
AL464_RS02275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL464_RS02285	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL464_RS02300	COG1136	(ABC) transporter
AL464_RS02320	COG0529	Catalyzes the synthesis of activated sulfate
AL464_RS02325	COG0471	metal ion transport
AL464_RS02325	COG3273	potassium ion transport
AL464_RS02330	COG2895	sulfate adenylyltransferase (ATP) activity
AL464_RS02335	COG0175	sulfate reduction
AL464_RS02340	COG1648	precorrin-2 dehydrogenase activity
AL464_RS02340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL464_RS02345	COG0737	Belongs to the 5'-nucleotidase family
AL464_RS02355	COG0513	Belongs to the DEAD box helicase family
AL464_RS02360	COG2153	protein acetylation
AL464_RS02370	COG0545	Peptidyl-prolyl cis-trans isomerase
AL464_RS02380	COG0203	ribosomal protein L17
AL464_RS02385	COG0202	RNA polymerase activity
AL464_RS02395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL464_RS02400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL464_RS02405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL464_RS02410	COG0201	protein transport
AL464_RS02415	COG0200	Binds to the 23S rRNA
AL464_RS02420	COG1841	ribosomal large subunit assembly
AL464_RS02435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL464_RS02440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL464_RS02445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL464_RS02450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL464_RS02455	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL464_RS02460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL464_RS02465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL464_RS02470	COG0255	Belongs to the universal ribosomal protein uL29 family
AL464_RS02480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL464_RS02485	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL464_RS02490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL464_RS02495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL464_RS02505	COG0088	Forms part of the polypeptide exit tunnel
AL464_RS02510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL464_RS02520	COG0254	rRNA binding
AL464_RS02525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL464_RS02530	COG1609	Transcriptional regulator
AL464_RS02540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL464_RS02545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL464_RS02550	COG1575	Belongs to the MenA family. Type 1 subfamily
AL464_RS02555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL464_RS02560	COG3074	FtsZ-dependent cytokinesis
AL464_RS02565	COG1494	fructose-1,6-bisphosphatase
AL464_RS02590	COG0149	triose-phosphate isomerase activity
AL464_RS02595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL464_RS02610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL464_RS02625	COG1482	cell wall glycoprotein biosynthetic process
AL464_RS02680	COG2089	acid synthase
AL464_RS02690	COG1083	cytidylyl-transferase
AL464_RS02695	COG1086	Polysaccharide biosynthesis protein
AL464_RS02730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL464_RS02740	COG1560	Kdo2-lipid A biosynthetic process
AL464_RS02745	COG0859	PFAM glycosyl transferase family 9
AL464_RS02750	COG1519	Transferase
AL464_RS02760	COG0438	transferase activity, transferring glycosyl groups
AL464_RS02760	COG0297	glycogen (starch) synthase activity
AL464_RS02780	COG2030	dehydratase
AL464_RS02785	COG0110	maltose O-acetyltransferase activity
AL464_RS02805	COG3642	lipopolysaccharide core region biosynthetic process
AL464_RS02810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL464_RS02815	COG0859	PFAM glycosyl transferase family 9
AL464_RS02820	COG0463	Glycosyl transferase, family 2
AL464_RS02835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL464_RS02840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL464_RS02855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL464_RS02860	COG2003	Belongs to the UPF0758 family
AL464_RS02865	COG0840	transmembrane signaling receptor activity
AL464_RS02870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL464_RS02875	COG1309	transcriptional regulator
AL464_RS02880	COG1560	Kdo2-lipid A biosynthetic process
AL464_RS02885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL464_RS02890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL464_RS02895	COG1561	YicC-like family, N-terminal region
AL464_RS02905	COG2246	polysaccharide biosynthetic process
AL464_RS02920	COG2801	Transposase and inactivated derivatives
AL464_RS02925	COG2963	transposase activity
AL464_RS02955	COG5001	Diguanylate cyclase
AL464_RS02965	COG4608	Belongs to the ABC transporter superfamily
AL464_RS02970	COG0444	Belongs to the ABC transporter superfamily
AL464_RS02975	COG0747	negative chemotaxis
AL464_RS02980	COG4239	(ABC) transporter, permease
AL464_RS02985	COG4174	ABC transporter (Permease)
AL464_RS03005	COG0811	peptide transport
AL464_RS03010	COG0848	biopolymer transport protein
AL464_RS03025	COG0194	GDP metabolic process
AL464_RS03030	COG1758	RNA polymerase activity
AL464_RS03035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL464_RS03040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL464_RS03045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL464_RS03055	COG2233	PERMEase
AL464_RS03075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL464_RS03085	COG2183	response to ionizing radiation
AL464_RS03095	COG0596	Alpha beta hydrolase
AL464_RS03100	COG1040	competence protein
AL464_RS03105	COG0316	Belongs to the HesB IscA family
AL464_RS03105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL464_RS03110	COG0494	nUDIX hydrolase
AL464_RS03115	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL464_RS03125	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL464_RS03130	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL464_RS03135	COG3156	type II secretion system protein K
AL464_RS03140	COG4795	General secretion pathway protein
AL464_RS03145	COG2165	general secretion pathway protein
AL464_RS03150	COG2165	general secretion pathway protein
AL464_RS03155	COG2165	general secretion pathway protein
AL464_RS03160	COG1459	type II secretion system
AL464_RS03165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL464_RS03175	COG3031	protein transport across the cell outer membrane
AL464_RS03180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL464_RS03185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL464_RS03190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL464_RS03200	COG0456	acetyltransferase
AL464_RS03205	COG1490	D-aminoacyl-tRNA deacylase activity
AL464_RS03210	COG1295	ribonuclease BN
AL464_RS03225	COG1217	gtp-binding protein TYPA
AL464_RS03230	COG0174	glutamine synthetase
AL464_RS03240	COG3852	Histidine kinase
AL464_RS03245	COG2204	response regulator
AL464_RS03255	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL464_RS03290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL464_RS03295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL464_RS03295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL464_RS03310	COG0084	hydrolase, TatD family'
AL464_RS03315	COG0805	protein transport
AL464_RS03320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL464_RS03325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL464_RS03330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL464_RS03335	COG3165	ubiquinone biosynthetic process from chorismate
AL464_RS03340	COG2226	methyltransferase
AL464_RS03345	COG1322	Protein conserved in bacteria
AL464_RS03360	COG0628	permease
AL464_RS03415	COG2081	HI0933 family
AL464_RS03425	COG1528	Iron-storage protein
AL464_RS03430	COG0589	response to stress
AL464_RS03445	COG0742	ribosomal rna small subunit methyltransferase
AL464_RS03450	COG5001	Diguanylate cyclase
AL464_RS03450	COG5002	protein histidine kinase activity
AL464_RS03455	COG1522	sequence-specific DNA binding
AL464_RS03460	COG0339	signal peptide processing
AL464_RS03465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL464_RS03470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL464_RS03475	COG0583	DNA-binding transcription factor activity
AL464_RS03480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL464_RS03485	COG0800	Aldolase
AL464_RS03490	COG2610	gluconate transmembrane transporter activity
AL464_RS03495	COG3265	gluconokinase activity
AL464_RS03500	COG0129	dihydroxy-acid dehydratase activity
AL464_RS03515	COG0583	DNA-binding transcription factor activity
AL464_RS03520	COG1609	Transcriptional regulator
AL464_RS03555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL464_RS03560	COG0601	transmembrane transport
AL464_RS03565	COG0747	negative chemotaxis
AL464_RS03570	COG4172	Belongs to the ABC transporter superfamily
AL464_RS03625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_RS03630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_RS03635	COG2960	long-chain fatty acid transporting porin activity
AL464_RS03640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL464_RS03645	COG0583	DNA-binding transcription factor activity
AL464_RS03680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL464_RS03685	COG1739	Uncharacterized protein family UPF0029
AL464_RS03690	COG1024	Enoyl-CoA hydratase
AL464_RS03690	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL464_RS03695	COG0183	Belongs to the thiolase family
AL464_RS03700	COG0604	alcohol dehydrogenase
AL464_RS03715	COG0425	Belongs to the sulfur carrier protein TusA family
AL464_RS03725	COG2119	membrane
AL464_RS03730	COG0752	glycyl-tRNA synthetase alpha subunit
AL464_RS03735	COG0751	glycine-tRNA ligase activity
AL464_RS03745	COG3977	Valine--pyruvate aminotransferase
AL464_RS03750	COG0071	Belongs to the small heat shock protein (HSP20) family
AL464_RS03760	COG0187	DNA topoisomerase II activity
AL464_RS03765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL464_RS03770	COG0592	DNA-directed DNA polymerase activity
AL464_RS03775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL464_RS03790	COG1126	abc transporter atp-binding protein
AL464_RS03800	COG0594	ribonuclease P activity
AL464_RS03805	COG0706	membrane insertase activity
AL464_RS03810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL464_RS03815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL464_RS03820	COG0445	tRNA wobble uridine modification
AL464_RS03825	COG0357	Ribosomal RNA small subunit methyltransferase G
AL464_RS03830	COG1192	Involved in chromosome partitioning
AL464_RS03835	COG1475	DNA binding
AL464_RS03840	COG3312	ion transport
AL464_RS03845	COG0356	it plays a direct role in the translocation of protons across the membrane
AL464_RS03860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL464_RS03865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL464_RS03870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL464_RS03875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL464_RS03880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL464_RS03885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL464_RS03890	COG0765	amino acid transport
AL464_RS03895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_RS03900	COG2814	Major facilitator Superfamily
AL464_RS03905	COG0583	DNA-binding transcription factor activity
AL464_RS03915	COG0129	dihydroxy-acid dehydratase activity
AL464_RS03920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL464_RS03925	COG3978	acetolactate synthase activity
AL464_RS03935	COG0606	chelatase, subunit chli
AL464_RS03945	COG0204	Acyl-transferase
AL464_RS03950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL464_RS03955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL464_RS03965	COG3084	Protein conserved in bacteria
AL464_RS03970	COG4326	sporulation control protein
AL464_RS03975	COG1272	protein, Hemolysin III
AL464_RS03985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL464_RS03990	COG0569	domain protein
AL464_RS03995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL464_RS03995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL464_RS04000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL464_RS04005	COG0242	peptide deformylase activity
AL464_RS04015	COG0758	DNA mediated transformation
AL464_RS04020	COG2922	Belongs to the Smg family
AL464_RS04025	COG0551	DNA topoisomerase type I activity
AL464_RS04030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL464_RS04035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL464_RS04040	COG0009	L-threonylcarbamoyladenylate synthase
AL464_RS04045	COG0408	coproporphyrinogen oxidase activity
AL464_RS04050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL464_RS04060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL464_RS04110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL464_RS04115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL464_RS04125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL464_RS04130	COG2104	thiamine diphosphate biosynthetic process
AL464_RS04135	COG2022	thiamine diphosphate biosynthetic process
AL464_RS04145	COG0006	proline dipeptidase activity
AL464_RS04145	COG0006	proline dipeptidase activity
AL464_RS04175	COG3220	belongs to the UPF0276 family
AL464_RS04185	COG0210	DNA helicase
AL464_RS04190	COG0405	Gamma-glutamyltransferase
AL464_RS04195	COG1280	lysine exporter protein (LysE YggA)
AL464_RS04205	COG2962	Rard protein
AL464_RS04210	COG0514	ATP-dependent DNA helicase (RecQ)
AL464_RS04220	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL464_RS04225	COG0248	Ppx GppA phosphatase
AL464_RS04230	COG0513	Belongs to the DEAD box helicase family
AL464_RS04235	COG3118	belongs to the thioredoxin family
AL464_RS04250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL464_RS04255	COG0633	Ferredoxin
AL464_RS04325	COG3071	HemY protein
AL464_RS04330	COG2959	enzyme of heme biosynthesis
AL464_RS04335	COG1587	Uroporphyrinogen-III synthase
AL464_RS04340	COG0181	hydroxymethylbilane synthase activity
AL464_RS04345	COG3072	Adenylate cyclase
AL464_RS04350	COG1965	Belongs to the frataxin family
AL464_RS04360	COG0019	diaminopimelate decarboxylase activity
AL464_RS04365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL464_RS04375	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL464_RS04380	COG1011	Hydrolase
AL464_RS04385	COG2200	EAL domain
AL464_RS04385	COG3287	FIST C domain
AL464_RS04385	COG2199	diguanylate cyclase activity
AL464_RS04390	COG3148	PFAM DTW domain containing protein
AL464_RS04405	COG0561	phosphatase activity
AL464_RS04410	COG2267	carboxylic ester hydrolase activity
AL464_RS04415	COG1280	lysine exporter protein (LysE YggA)
AL464_RS04420	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL464_RS04425	COG0640	Transcriptional regulator
AL464_RS04430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL464_RS04480	COG2095	MarC family integral membrane protein
AL464_RS04490	COG0742	ribosomal rna small subunit methyltransferase
AL464_RS04495	COG0552	protein localization to endoplasmic reticulum
AL464_RS04500	COG2884	Cell division ATP-binding protein ftsE
AL464_RS04505	COG2177	Part of the ABC transporter FtsEX involved in
AL464_RS04515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL464_RS04520	COG0705	Rhomboid family
AL464_RS04525	COG1580	Controls the rotational direction of flagella during chemotaxis
AL464_RS04530	COG3161	chorismate lyase activity
AL464_RS04535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL464_RS04540	COG2937	Belongs to the GPAT DAPAT family
AL464_RS04545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL464_RS04550	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AL464_RS04555	COG0534	Mate efflux family protein
AL464_RS04560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL464_RS04580	COG4206	TonB-dependent receptor
AL464_RS04590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL464_RS04620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL464_RS04630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL464_RS04665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL464_RS04670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL464_RS04675	COG0250	Participates in transcription elongation, termination and antitermination
AL464_RS04680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL464_RS04685	COG0081	regulation of translation
AL464_RS04690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL464_RS04695	COG0222	ribosome binding
AL464_RS04700	COG0085	RNA polymerase activity
AL464_RS04705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL464_RS04710	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL464_RS04715	COG2816	NAD+ diphosphatase activity
AL464_RS04730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL464_RS04735	COG1573	uracil-dna glycosylase
AL464_RS04740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL464_RS04750	COG1253	flavin adenine dinucleotide binding
AL464_RS04765	COG0151	Belongs to the GarS family
AL464_RS04770	COG0138	bifunctional purine biosynthesis protein purh
AL464_RS04775	COG0789	Transcriptional regulator
AL464_RS04780	COG3710	Transcriptional regulator
AL464_RS04790	COG0531	amino acid
AL464_RS04795	COG1982	Orn Lys Arg decarboxylase major
AL464_RS04950	COG1410	methionine synthase
AL464_RS04950	COG0646	methionine synthase
AL464_RS04955	COG0527	aspartate kinase activity
AL464_RS04965	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL464_RS04975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL464_RS04990	COG0629	single-stranded DNA binding
AL464_RS04995	COG2199	diguanylate cyclase activity
AL464_RS04995	COG2200	EAL domain
AL464_RS05020	COG3267	Type II secretory pathway component ExeA
AL464_RS05020	COG3409	Peptidoglycan-binding domain 1 protein
AL464_RS05030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL464_RS05035	COG1459	type II secretion system
AL464_RS05080	COG1077	Cell shape determining protein MreB Mrl
AL464_RS05085	COG1792	Involved in formation and maintenance of cell shape
AL464_RS05090	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL464_RS05095	COG0424	maF-like protein
AL464_RS05105	COG3164	Protein of unknown function
AL464_RS05110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL464_RS05115	COG0312	modulator of DNA gyrase
AL464_RS05120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL464_RS05125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL464_RS05135	COG0564	pseudouridine synthase activity
AL464_RS05140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL464_RS05145	COG3028	Belongs to the UPF0307 family
AL464_RS05150	COG0312	modulator of DNA gyrase
AL464_RS05155	COG2239	Acts as a magnesium transporter
AL464_RS05160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_RS05165	COG1660	Displays ATPase and GTPase activities
AL464_RS05170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_RS05175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL464_RS05185	COG1137	ATPase activity
AL464_RS05190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL464_RS05200	COG0517	IMP dehydrogenase activity
AL464_RS05200	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL464_RS05210	COG1127	ABC transporter
AL464_RS05215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL464_RS05220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL464_RS05225	COG2854	intermembrane phospholipid transfer
AL464_RS05235	COG5007	Belongs to the BolA IbaG family
AL464_RS05240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL464_RS05245	COG0204	Acyl-transferase
AL464_RS05250	COG0251	oxidation-reduction process
AL464_RS05255	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL464_RS05260	COG0540	Belongs to the ATCase OTCase family
AL464_RS05265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL464_RS05270	COG2235	arginine
AL464_RS05295	COG0525	valine-tRNA ligase activity
AL464_RS05300	COG2927	DNA polymerase III (CHI subunit)
AL464_RS05305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL464_RS05310	COG0795	lipopolysaccharide-transporting ATPase activity
AL464_RS05315	COG0795	lipopolysaccharide-transporting ATPase activity
AL464_RS05330	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_RS05425	COG0726	polysaccharide deacetylase
AL464_RS05430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL464_RS05435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL464_RS05440	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL464_RS05445	COG1486	melibiose metabolic process
AL464_RS05450	COG3394	polysaccharide catabolic process
AL464_RS05460	COG3437	response regulator, receiver
AL464_RS05495	COG3706	GGDEF domain
AL464_RS05500	COG0488	(ABC) transporter
AL464_RS05505	COG2814	Major facilitator Superfamily
AL464_RS05510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL464_RS05515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL464_RS05520	COG2264	protein methyltransferase activity
AL464_RS05525	COG0439	Biotin carboxylase
AL464_RS05530	COG0511	ligase activity, forming carbon-carbon bonds
AL464_RS05535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL464_RS05540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL464_RS05555	COG2814	Major facilitator Superfamily
AL464_RS05560	COG2198	Histidine kinase
AL464_RS05560	COG2205	protein histidine kinase activity
AL464_RS05560	COG0784	Response regulator, receiver
AL464_RS05580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL464_RS05590	COG3263	regulation of cellular component size
AL464_RS05600	COG4232	protein-disulfide reductase activity
AL464_RS05605	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL464_RS05610	COG1027	Aspartate ammonia-lyase
AL464_RS05615	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL464_RS05620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL464_RS05630	COG2205	protein histidine kinase activity
AL464_RS05635	COG0745	RESPONSE REGULATOR receiver
AL464_RS05640	COG3678	ATP-independent chaperone mediated protein folding
AL464_RS05650	COG0205	6-phosphofructokinase activity
AL464_RS05655	COG0534	Mate efflux family protein
AL464_RS05665	COG0459	protein refolding
AL464_RS05680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL464_RS05685	COG1509	lysine 2,3-aminomutase activity
AL464_RS05690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL464_RS05700	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL464_RS05705	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL464_RS05710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL464_RS05715	COG1053	succinate dehydrogenase
AL464_RS05720	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL464_RS05740	COG4942	peptidase
AL464_RS05745	COG1045	serine acetyltransferase
AL464_RS05750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL464_RS05755	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL464_RS05760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL464_RS05765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL464_RS05775	COG0840	transmembrane signaling receptor activity
AL464_RS05780	COG0471	metal ion transport
AL464_RS05785	COG0688	phosphatidylethanolamine metabolic process
AL464_RS05790	COG1162	GTPase activity
AL464_RS05795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL464_RS05865	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL464_RS05870	COG0802	atpase or kinase
AL464_RS05880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL464_RS05885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL464_RS05895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL464_RS05900	COG0330	HflC and HflK could
AL464_RS05905	COG0330	HflC and HflK could
AL464_RS05910	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL464_RS05915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL464_RS05920	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL464_RS05925	COG1017	nitric oxide dioxygenase activity
AL464_RS05925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL464_RS05930	COG1959	2 iron, 2 sulfur cluster binding
AL464_RS05935	COG0557	exoribonuclease II activity
AL464_RS05940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL464_RS05945	COG0546	phosphoglycolate phosphatase activity
AL464_RS05950	COG0180	Tryptophanyl-tRNA synthetase
AL464_RS05965	COG0512	Glutamine amidotransferase of anthranilate synthase
AL464_RS05970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL464_RS05980	COG1012	belongs to the aldehyde dehydrogenase family
AL464_RS05990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL464_RS05995	COG3954	Phosphoribulokinase
AL464_RS06000	COG3089	Belongs to the UPF0270 family
AL464_RS06005	COG0429	hydrolase of the alpha beta-hydrolase fold
AL464_RS06015	COG0488	(ABC) transporter
AL464_RS06020	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL464_RS06035	COG1047	Peptidyl-prolyl cis-trans
AL464_RS06040	COG1446	asparaginase
AL464_RS06045	COG2900	Belongs to the SlyX family
AL464_RS06055	COG0545	Peptidyl-prolyl cis-trans isomerase
AL464_RS06060	COG2964	Protein conserved in bacteria
AL464_RS06065	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL464_RS06070	COG2923	Belongs to the DsrF TusC family
AL464_RS06085	COG0049	tRNA binding
AL464_RS06090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL464_RS06095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL464_RS06100	COG2906	2 iron, 2 sulfur cluster binding
AL464_RS06110	COG0281	malic enzyme
AL464_RS06120	COG0626	cystathionine gamma-synthase activity
AL464_RS06125	COG0460	homoserine dehydrogenase
AL464_RS06125	COG0527	aspartate kinase activity
AL464_RS06130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL464_RS06140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL464_RS06145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL464_RS06150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL464_RS06155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL464_RS06160	COG0137	argininosuccinate synthase activity
AL464_RS06165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL464_RS06165	COG0165	Argininosuccinate lyase
AL464_RS06175	COG0678	peroxiredoxin activity
AL464_RS06175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL464_RS06185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL464_RS06215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL464_RS06220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL464_RS06230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL464_RS06235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL464_RS06240	COG0360	Binds together with S18 to 16S ribosomal RNA
AL464_RS06245	COG2965	DNA replication, synthesis of RNA primer
AL464_RS06255	COG0359	binds to the 23S rRNA
AL464_RS06270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL464_RS06280	COG0432	Pfam Uncharacterised protein family UPF0047
AL464_RS06285	COG0166	Belongs to the GPI family
AL464_RS06295	COG0735	belongs to the Fur family
AL464_RS06300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL464_RS06320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL464_RS06325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL464_RS06330	COG0175	sulfate reduction
AL464_RS06375	COG1012	belongs to the aldehyde dehydrogenase family
AL464_RS06405	COG0840	transmembrane signaling receptor activity
AL464_RS06445	COG0741	lytic transglycosylase activity
AL464_RS06450	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL464_RS06460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL464_RS06470	COG2066	Belongs to the glutaminase family
AL464_RS06475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL464_RS06480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL464_RS06490	COG1872	DUF167
AL464_RS06495	COG0762	integral membrane protein
AL464_RS06500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL464_RS06505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL464_RS06520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL464_RS06525	COG1678	Uncharacterized ACR, COG1678
AL464_RS06530	COG0189	ligase activity
AL464_RS06535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL464_RS06540	COG2356	endonuclease I
AL464_RS06545	COG3091	SprT-like family
AL464_RS06555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL464_RS06565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL464_RS06570	COG0583	DNA-binding transcription factor activity
AL464_RS06575	COG4771	TonB-dependent receptor
AL464_RS06580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL464_RS06585	COG0126	phosphoglycerate kinase activity
AL464_RS06590	COG0191	fructose-bisphosphate aldolase activity
AL464_RS06595	COG0668	transmembrane transport
AL464_RS06600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL464_RS06610	COG0583	DNA-binding transcription factor activity
AL464_RS06620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL464_RS06625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL464_RS06630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL464_RS06640	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL464_RS06645	COG3079	Belongs to the UPF0149 family
AL464_RS06650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL464_RS06655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL464_RS06670	COG0354	folic acid binding
AL464_RS06675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL464_RS06680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL464_RS06685	COG1595	DNA-templated transcription, initiation
AL464_RS06690	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AL464_RS06700	COG3086	response to oxidative stress
AL464_RS06705	COG0481	GTPase activity
AL464_RS06715	COG0571	ribonuclease III activity
AL464_RS06720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL464_RS06725	COG1381	Involved in DNA repair and RecF pathway recombination
AL464_RS06730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL464_RS06735	COG0736	holo-[acyl-carrier-protein] synthase activity
AL464_RS06745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL464_RS06750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL464_RS06755	COG3956	TIGRFAM MazG family protein
AL464_RS06760	COG0504	CTP synthase activity
AL464_RS06765	COG0148	phosphopyruvate hydratase activity
AL464_RS06770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL464_RS06775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL464_RS06780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL464_RS06785	COG0585	pseudouridine synthase activity
AL464_RS06790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL464_RS06795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL464_RS06805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL464_RS06810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL464_RS06815	COG1546	Belongs to the CinA family
AL464_RS06820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL464_RS06825	COG2137	regulation of response to DNA damage stimulus
AL464_RS06830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL464_RS06835	COG0527	aspartate kinase activity
AL464_RS06885	COG3630	sodium ion export across plasma membrane
AL464_RS06890	COG5016	pyruvate
AL464_RS06890	COG0511	ligase activity, forming carbon-carbon bonds
AL464_RS06895	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL464_RS06905	COG1238	metal cluster binding
AL464_RS06910	COG0612	Peptidase, M16
AL464_RS06915	COG2918	glutathione biosynthetic process
AL464_RS06925	COG1854	S-ribosylhomocysteine lyase activity
AL464_RS06930	COG4536	flavin adenine dinucleotide binding
AL464_RS06935	COG4137	Cytochrome C assembly protein
AL464_RS06940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL464_RS06945	COG0228	four-way junction DNA binding
AL464_RS06950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL464_RS06955	COG0336	Belongs to the RNA methyltransferase TrmD family
AL464_RS06960	COG0335	large ribosomal subunit rRNA binding
AL464_RS06965	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL464_RS06970	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL464_RS06975	COG0237	dephospho-CoA kinase activity
AL464_RS06985	COG1459	type II secretion system
AL464_RS06990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL464_RS06995	COG4969	Belongs to the N-Me-Phe pilin family
AL464_RS07000	COG0157	Belongs to the NadC ModD family
AL464_RS07010	COG2186	Transcriptional regulator
AL464_RS07015	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL464_RS07020	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL464_RS07025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL464_RS07040	COG0288	reversible hydration of carbon dioxide
AL464_RS07045	COG0659	secondary active sulfate transmembrane transporter activity
AL464_RS07050	COG1131	(ABC) transporter
AL464_RS07055	COG0842	Transport permease protein
AL464_RS07060	COG1560	Kdo2-lipid A biosynthetic process
AL464_RS07065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL464_RS07070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL464_RS07075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL464_RS07085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL464_RS07095	COG1489	DNA binding
AL464_RS07100	COG1643	Atp-dependent helicase
AL464_RS07105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL464_RS07110	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL464_RS07115	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL464_RS07120	COG3112	Uncharacterised protein family (UPF0231)
AL464_RS07130	COG0004	ammonium transporteR
AL464_RS07135	COG1840	ABC-type Fe3 transport system, periplasmic component
AL464_RS07145	COG3842	ATPase activity
AL464_RS07150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL464_RS07165	COG2971	BadF BadG BcrA BcrD
AL464_RS07175	COG4608	Belongs to the ABC transporter superfamily
AL464_RS07180	COG0444	Belongs to the ABC transporter superfamily
AL464_RS07185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL464_RS07195	COG0747	negative chemotaxis
AL464_RS07200	COG2198	Histidine kinase
AL464_RS07200	COG2205	protein histidine kinase activity
AL464_RS07200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_RS07200	COG0784	Response regulator, receiver
AL464_RS07205	COG2813	Specifically methylates the guanine in position
AL464_RS07210	COG0628	permease
AL464_RS07215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL464_RS07220	COG0316	Belongs to the HesB IscA family
AL464_RS07230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_RS07235	COG0739	heme binding
AL464_RS07240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL464_RS07250	COG2027	D-alanyl-D-alanine carboxypeptidase
AL464_RS07255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL464_RS07260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL464_RS07265	COG1534	Rna-binding protein
AL464_RS07270	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL464_RS07275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL464_RS07280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL464_RS07285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL464_RS07295	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL464_RS07310	COG0779	Required for maturation of 30S ribosomal subunits
AL464_RS07315	COG0195	Participates in both transcription termination and antitermination
AL464_RS07320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL464_RS07325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL464_RS07330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL464_RS07335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL464_RS07340	COG1185	polyribonucleotide nucleotidyltransferase activity
AL464_RS07355	COG0534	Mate efflux family protein
AL464_RS07360	COG0826	peptidase U32
AL464_RS07365	COG0826	peptidase U32
AL464_RS07375	COG3154	lipid carrier protein
AL464_RS07380	COG3153	acetyltransferase
AL464_RS07400	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL464_RS07410	COG0084	hydrolase, TatD family'
AL464_RS07415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL464_RS07420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL464_RS07425	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL464_RS07430	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL464_RS07435	COG0813	purine-nucleoside phosphorylase activity
AL464_RS07445	COG0560	Phosphoserine phosphatase
AL464_RS07455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL464_RS07460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL464_RS07465	COG0583	DNA-binding transcription factor activity
AL464_RS07475	COG1022	Amp-dependent synthetase and ligase
AL464_RS07480	COG2169	Transcriptional regulator
AL464_RS07500	COG4964	Belongs to the GSP D family
AL464_RS07560	COG0583	DNA-binding transcription factor activity
AL464_RS07565	COG0531	amino acid
AL464_RS07570	COG2731	YhcH YjgK YiaL family protein
AL464_RS07575	COG3250	beta-galactosidase activity
AL464_RS07580	COG1609	Transcriptional regulator
AL464_RS07585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL464_RS07590	COG1085	galactose-1-phosphate uridylyltransferase
AL464_RS07595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL464_RS07600	COG2017	converts alpha-aldose to the beta-anomer
AL464_RS07615	COG2176	DNA-directed DNA polymerase activity
AL464_RS07620	COG1609	Transcriptional regulator
AL464_RS07625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL464_RS07640	COG0598	Magnesium transport protein CorA
AL464_RS07645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL464_RS07655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL464_RS07660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL464_RS07665	COG2271	Major facilitator Superfamily
AL464_RS07670	COG0584	glycerophosphoryl diester phosphodiesterase
AL464_RS07675	COG2171	N-acyltransferase activity
AL464_RS07680	COG3141	response to X-ray
AL464_RS07710	COG1074	ATP-dependent DNA helicase activity
AL464_RS07715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL464_RS07720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL464_RS07720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL464_RS07730	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL464_RS07735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL464_RS07740	COG2166	iron-sulfur cluster assembly
AL464_RS07745	COG3706	GGDEF domain
AL464_RS07750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL464_RS07755	COG0693	protein deglycase activity
AL464_RS07760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL464_RS07780	COG1595	DNA-templated transcription, initiation
AL464_RS07800	COG3056	Lipoprotein
AL464_RS07805	COG2813	Specifically methylates the guanine in position
AL464_RS07810	COG0271	Belongs to the BolA IbaG family
AL464_RS07815	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL464_RS07820	COG1805	sodium ion transport
AL464_RS07825	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL464_RS07830	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL464_RS07835	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL464_RS07840	COG2871	sodium ion transport
AL464_RS07845	COG1477	protein flavinylation
AL464_RS07860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL464_RS07865	COG0514	ATP-dependent DNA helicase (RecQ)
AL464_RS07870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL464_RS07885	COG0733	neurotransmitter:sodium symporter activity
AL464_RS07905	COG0442	prolyl-tRNA aminoacylation
AL464_RS07910	COG1720	tRNA m6t6A37 methyltransferase activity
AL464_RS07915	COG0254	rRNA binding
AL464_RS07920	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL464_RS07925	COG1671	Belongs to the UPF0178 family
AL464_RS07945	COG3098	single-species biofilm formation
AL464_RS07950	COG0564	pseudouridine synthase activity
AL464_RS07960	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL464_RS07965	COG0024	Methionine aminopeptidase
AL464_RS07970	COG0052	Belongs to the universal ribosomal protein uS2 family
AL464_RS07975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL464_RS07980	COG0528	UMP kinase activity
AL464_RS07985	COG0233	cytoplasmic translational termination
AL464_RS07990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL464_RS07995	COG0575	Belongs to the CDS family
AL464_RS08000	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL464_RS08005	COG0750	zinc metalloprotease
AL464_RS08015	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL464_RS08020	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL464_RS08025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL464_RS08030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL464_RS08035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL464_RS08040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL464_RS08045	COG0587	DNA-directed DNA polymerase activity
AL464_RS08050	COG0825	malonyl-CoA metabolic process
AL464_RS08055	COG0037	tRNA processing
AL464_RS08065	COG0347	Belongs to the P(II) protein family
AL464_RS08070	COG3021	interspecies interaction between organisms
AL464_RS08080	COG0741	lytic transglycosylase activity
AL464_RS08080	COG1388	LysM domain
AL464_RS08085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL464_RS08090	COG2226	methyltransferase
AL464_RS08095	COG0328	RNA-DNA hybrid ribonuclease activity
AL464_RS08100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL464_RS08115	COG1960	acyl-CoA dehydrogenase activity
AL464_RS08120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL464_RS08125	COG0121	glutamine amidotransferase
AL464_RS08130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL464_RS08135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL464_RS08140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL464_RS08145	COG2233	PERMEase
AL464_RS08165	COG1393	Belongs to the ArsC family
AL464_RS08170	COG4783	chaperone-mediated protein folding
AL464_RS08185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL464_RS08190	COG2716	regulation of RNA biosynthetic process
AL464_RS08195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL464_RS08200	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL464_RS08215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL464_RS08220	COG1393	Belongs to the ArsC family
AL464_RS08245	COG2837	iron assimilation
AL464_RS08250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_RS08255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_RS08260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_RS08265	COG1334	flagellar protein FlaG
AL464_RS08270	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL464_RS08280	COG1516	flagellar protein fliS
AL464_RS08300	COG1677	Flagellar hook-basal body complex protein FliE
AL464_RS08310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL464_RS08360	COG1987	bacterial-type flagellum assembly
AL464_RS08365	COG1684	flagellar biosynthetic protein fliR
AL464_RS08400	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL464_RS08410	COG2201	protein-glutamate methylesterase activity
AL464_RS08415	COG1192	Involved in chromosome partitioning
AL464_RS08425	COG0835	chemotaxis
AL464_RS08435	COG4133	protoheme IX ABC transporter activity
AL464_RS08440	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL464_RS08445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL464_RS08450	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL464_RS08455	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL464_RS08460	COG1138	Cytochrome C-type biogenesis protein
AL464_RS08465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL464_RS08480	COG2853	Lipoprotein
AL464_RS08490	COG2067	long-chain fatty acid transport protein
AL464_RS08510	COG0183	Belongs to the thiolase family
AL464_RS08515	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL464_RS08515	COG1024	Enoyl-CoA hydratase
AL464_RS08530	COG2062	phosphohistidine phosphatase, SixA
AL464_RS08535	COG2840	Smr protein MutS2
AL464_RS08540	COG2890	protein-(glutamine-N5) methyltransferase activity
AL464_RS08545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL464_RS08550	COG2860	membrane
AL464_RS08555	COG3101	peptidyl-lysine hydroxylation
AL464_RS08565	COG0431	NADPH-dependent FMN reductase
AL464_RS08570	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL464_RS08570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL464_RS08575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL464_RS08580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL464_RS08585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL464_RS08595	COG0101	tRNA pseudouridine synthase activity
AL464_RS08600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL464_RS08605	COG0285	dihydrofolate synthase activity
AL464_RS08610	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL464_RS08615	COG1286	toxin biosynthetic process
AL464_RS08620	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL464_RS08630	COG0583	DNA-binding transcription factor activity
AL464_RS08635	COG0745	RESPONSE REGULATOR receiver
AL464_RS08640	COG2832	Protein of unknown function (DUF454)
AL464_RS08645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL464_RS08655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL464_RS08660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL464_RS08665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL464_RS08670	COG0814	amino acid
AL464_RS08675	COG0251	oxidation-reduction process
AL464_RS08680	COG3681	Belongs to the UPF0597 family
AL464_RS08695	COG2261	transglycosylase associated protein
AL464_RS08700	COG2983	Belongs to the UPF0260 family
AL464_RS08705	COG0668	transmembrane transport
AL464_RS08710	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL464_RS08715	COG0346	lactoylglutathione lyase activity
AL464_RS08725	COG1785	Belongs to the alkaline phosphatase family
AL464_RS08740	COG2226	methyltransferase
AL464_RS08755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL464_RS08760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL464_RS08770	COG3139	Protein of unknown function (DUF1315)
AL464_RS08775	COG0252	asparaginase activity
AL464_RS08780	COG0616	signal peptide processing
AL464_RS08785	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL464_RS08785	COG1902	pentaerythritol trinitrate reductase activity
AL464_RS08790	COG0778	Nitroreductase
AL464_RS08795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL464_RS08810	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL464_RS08820	COG3083	sulfuric ester hydrolase activity
AL464_RS08825	COG3082	Protein of unknown function (DUF1414)
AL464_RS08830	COG3081	Nucleoid-associated protein
AL464_RS08845	COG1757	Na H antiporter
AL464_RS08850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL464_RS08855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL464_RS08860	COG2095	MarC family integral membrane protein
AL464_RS08865	COG1012	belongs to the aldehyde dehydrogenase family
AL464_RS08865	COG1454	alcohol dehydrogenase
AL464_RS08885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL464_RS08895	COG2056	Na+-H+ antiporter family
AL464_RS08900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL464_RS08905	COG2885	chlorophyll binding
AL464_RS08915	COG0346	lactoylglutathione lyase activity
AL464_RS08920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL464_RS08925	COG4660	Part of a membrane complex involved in electron transport
AL464_RS08930	COG4659	FMN binding
AL464_RS08935	COG4658	electron transport chain
AL464_RS08940	COG4656	Part of a membrane complex involved in electron transport
AL464_RS08945	COG2878	Part of a membrane complex involved in electron transport
AL464_RS08950	COG4657	Part of a membrane complex involved in electron transport
AL464_RS08960	COG0556	nucleotide-excision repair
AL464_RS08965	COG2204	response regulator
AL464_RS08970	COG2198	Histidine kinase
AL464_RS08975	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL464_RS08980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL464_RS08985	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL464_RS08990	COG0315	cyclic pyranopterin monophosphate synthase activity
AL464_RS08995	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL464_RS09000	COG0314	molybdopterin synthase activity
AL464_RS09010	COG0601	transmembrane transport
AL464_RS09015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL464_RS09020	COG0444	Belongs to the ABC transporter superfamily
AL464_RS09030	COG0435	Glutathione S-transferase
AL464_RS09040	COG3174	membrane
AL464_RS09045	COG0857	belongs to the CobB CobQ family
AL464_RS09045	COG0280	phosphate acetyltransferase
AL464_RS09050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL464_RS09055	COG3092	negative regulation of chromosome organization
AL464_RS09065	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL464_RS09070	COG1122	ATPase activity
AL464_RS09075	COG0366	Alpha amylase catalytic
AL464_RS09085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL464_RS09090	COG0653	protein targeting
AL464_RS09095	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL464_RS09100	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL464_RS09105	COG2186	Transcriptional regulator
AL464_RS09115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL464_RS09115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL464_RS09120	COG0489	protein tyrosine kinase activity
AL464_RS09125	COG0572	uridine kinase
AL464_RS09135	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL464_RS09140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL464_RS09145	COG0659	secondary active sulfate transmembrane transporter activity
AL464_RS09150	COG1530	ribonuclease E activity
AL464_RS09155	COG0564	pseudouridine synthase activity
AL464_RS09160	COG0424	maF-like protein
AL464_RS09165	COG1399	metal-binding, possibly nucleic acid-binding protein
AL464_RS09175	COG0416	fatty acid biosynthetic process
AL464_RS09180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL464_RS09210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL464_RS09215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL464_RS09225	COG0084	hydrolase, TatD family'
AL464_RS09230	COG1263	PTS System
AL464_RS09230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL464_RS09240	COG0733	neurotransmitter:sodium symporter activity
AL464_RS09250	COG4667	esterase of the alpha-beta hydrolase superfamily
AL464_RS09255	COG0469	pyruvate kinase activity
AL464_RS09260	COG1940	carbohydrate kinase activity
AL464_RS09265	COG0835	chemotaxis
AL464_RS09265	COG0784	Response regulator, receiver
AL464_RS09270	COG0587	DNA-directed DNA polymerase activity
AL464_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_RS09290	COG0616	signal peptide processing
AL464_RS09295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL464_RS09300	COG0539	negative regulation of cytoplasmic translation
AL464_RS09310	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL464_RS09315	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL464_RS09320	COG0284	orotidine-5'-phosphate decarboxylase activity
AL464_RS09325	COG4166	transmembrane transport
AL464_RS09350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL464_RS09360	COG3008	intermembrane lipid transfer
AL464_RS09360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL464_RS09365	COG2995	paraquat-inducible protein a
AL464_RS09370	COG3258	Cytochrome c
AL464_RS09375	COG2863	cytochrome
AL464_RS09415	COG4232	protein-disulfide reductase activity
AL464_RS09420	COG3118	belongs to the thioredoxin family
AL464_RS09450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_RS09460	COG1136	(ABC) transporter
AL464_RS09460	COG0577	efflux transmembrane transporter activity
AL464_RS09465	COG1136	(ABC) transporter
AL464_RS09465	COG0577	efflux transmembrane transporter activity
AL464_RS09470	COG1136	(ABC) transporter
AL464_RS09470	COG0577	efflux transmembrane transporter activity
AL464_RS09475	COG1335	isochorismatase
AL464_RS09525	COG5002	protein histidine kinase activity
AL464_RS09525	COG3850	Histidine kinase
AL464_RS09530	COG0745	RESPONSE REGULATOR receiver
AL464_RS09535	COG0840	transmembrane signaling receptor activity
AL464_RS09540	COG1032	radical SAM domain protein
AL464_RS09545	COG2203	Gaf domain
AL464_RS09545	COG5001	Diguanylate cyclase
AL464_RS09545	COG3706	GGDEF domain
AL464_RS09545	COG4251	negative regulation of phosphorylation
AL464_RS09560	COG0583	DNA-binding transcription factor activity
AL464_RS09565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL464_RS09575	COG2350	Protein conserved in bacteria
AL464_RS09585	COG2917	probably involved in intracellular septation
AL464_RS09605	COG1301	dicarboxylic acid transport
AL464_RS09610	COG0318	PFAM AMP-dependent synthetase and ligase
AL464_RS09615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL464_RS09620	COG0159	tryptophan synthase activity
AL464_RS09625	COG0133	tryptophan synthase activity
AL464_RS09630	COG0135	phosphoribosylanthranilate isomerase activity
AL464_RS09630	COG0134	indole-3-glycerol-phosphate synthase activity
AL464_RS09635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL464_RS09640	COG0512	Glutamine amidotransferase of anthranilate synthase
AL464_RS09645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL464_RS09655	COG0613	PHP domain protein
AL464_RS09660	COG0009	L-threonylcarbamoyladenylate synthase
AL464_RS09670	COG1187	pseudouridine synthase activity
AL464_RS09675	COG3099	Belongs to the UPF0263 family
AL464_RS09680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL464_RS09690	COG0417	DNA replication proofreading
AL464_RS09695	COG2197	response regulator
AL464_RS09700	COG0322	excinuclease ABC activity
AL464_RS09740	COG0019	diaminopimelate decarboxylase activity
AL464_RS09765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL464_RS09770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL464_RS09775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL464_RS09795	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL464_RS09805	COG0437	4 iron, 4 sulfur cluster binding
AL464_RS09810	COG3301	Polysulphide reductase, NrfD
AL464_RS09815	COG1138	Cytochrome C-type biogenesis protein
AL464_RS09825	COG3088	subunit of a heme lyase
AL464_RS09825	COG4235	cytochrome complex assembly
AL464_RS09835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL464_RS09860	COG2989	Protein conserved in bacteria
AL464_RS09865	COG3108	Peptidase M15
AL464_RS09870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL464_RS09885	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL464_RS09910	COG1846	Transcriptional regulator
AL464_RS09915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL464_RS09940	COG1448	Aminotransferase
AL464_RS09955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL464_RS09965	COG0017	Asparaginyl-tRNA synthetase
AL464_RS09975	COG0720	synthase
AL464_RS09985	COG2200	EAL domain
AL464_RS09990	COG1760	l-serine dehydratase
AL464_RS09995	COG0814	amino acid
AL464_RS10000	COG0494	nUDIX hydrolase
AL464_RS10010	COG2205	protein histidine kinase activity
AL464_RS10010	COG0784	Response regulator, receiver
AL464_RS10015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL464_RS10030	COG3106	COG3106 Predicted ATPase
AL464_RS10035	COG3768	UPF0283 membrane protein
AL464_RS10045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL464_RS10165	COG0346	lactoylglutathione lyase activity
AL464_RS10295	COG0251	oxidation-reduction process
AL464_RS10300	COG0346	lactoylglutathione lyase activity
AL464_RS10320	COG0456	acetyltransferase
AL464_RS10330	COG0454	-acetyltransferase
AL464_RS10455	COG1280	lysine exporter protein (LysE YggA)
AL464_RS10460	COG1280	lysine exporter protein (LysE YggA)
AL464_RS10510	COG0456	acetyltransferase
AL464_RS10550	COG1280	lysine exporter protein (LysE YggA)
AL464_RS10555	COG0582	viral genome integration into host DNA
AL464_RS10585	COG3422	double-strand break repair
AL464_RS10600	COG2194	sulfuric ester hydrolase activity
AL464_RS10605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL464_RS10650	COG0251	oxidation-reduction process
AL464_RS10675	COG0456	acetyltransferase
AL464_RS10675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL464_RS10695	COG0653	protein targeting
AL464_RS10710	COG2026	Addiction module toxin, RelE StbE family
AL464_RS10745	COG2801	Transposase and inactivated derivatives
AL464_RS10765	COG1757	Na H antiporter
AL464_RS10770	COG0174	glutamine synthetase
AL464_RS10775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AL464_RS10780	COG1396	sequence-specific DNA binding
AL464_RS10780	COG1917	Cupin 2, conserved barrel domain protein
AL464_RS10785	COG1012	belongs to the aldehyde dehydrogenase family
AL464_RS10790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL464_RS10800	COG2957	Belongs to the agmatine deiminase family
AL464_RS10805	COG1012	belongs to the aldehyde dehydrogenase family
AL464_RS10810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL464_RS10815	COG1227	inorganic diphosphatase activity
AL464_RS10820	COG2200	EAL domain
AL464_RS10820	COG2771	luxR family
AL464_RS10835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL464_RS10850	COG1846	Transcriptional regulator
AL464_RS10855	COG2315	Protein conserved in bacteria
AL464_RS10875	COG0110	maltose O-acetyltransferase activity
AL464_RS10905	COG3063	Type IV pilus biogenesis stability protein PilW
AL464_RS10910	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL464_RS10920	COG0531	amino acid
AL464_RS10925	COG1560	Kdo2-lipid A biosynthetic process
AL464_RS10930	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL464_RS10935	COG1280	lysine exporter protein (LysE YggA)
AL464_RS10945	COG1115	amino acid carrier protein
AL464_RS10965	COG1368	sulfuric ester hydrolase activity
AL464_RS10970	COG0642	Histidine kinase
AL464_RS10975	COG0745	RESPONSE REGULATOR receiver
AL464_RS10985	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_RS11005	COG2113	Glycine betaine
AL464_RS11010	COG4176	ABC-type proline glycine betaine transport system permease component
AL464_RS11030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL464_RS11035	COG0456	acetyltransferase
AL464_RS11040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL464_RS11045	COG0662	Cupin 2, conserved barrel domain protein
AL464_RS11050	COG0527	aspartate kinase activity
AL464_RS11055	COG1858	cytochrome C peroxidase
AL464_RS11070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_RS11085	COG3290	protein histidine kinase activity
AL464_RS11090	COG4565	transcriptional regulatory protein
AL464_RS11095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL464_RS11100	COG0363	glucosamine-6-phosphate deaminase activity
AL464_RS11105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL464_RS11115	COG3284	Transcriptional regulator
AL464_RS11120	COG1012	belongs to the aldehyde dehydrogenase family
AL464_RS11190	COG4669	(LipO)protein
AL464_RS11210	COG3177	Filamentation induced by cAMP protein fic
AL464_RS11245	COG0583	DNA-binding transcription factor activity
AL464_RS11255	COG1073	alpha beta
AL464_RS11260	COG1073	alpha beta
AL464_RS11270	COG4792	protein secretion
AL464_RS11275	COG4791	protein targeting
AL464_RS11280	COG4794	Type iii secretion
AL464_RS11285	COG4790	Type iii secretion
AL464_RS11355	COG0457	Tetratricopeptide repeat
AL464_RS11375	COG0730	response to heat
AL464_RS11405	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL464_RS11410	COG0372	Belongs to the citrate synthase family
AL464_RS11420	COG2828	Protein conserved in bacteria
AL464_RS11445	COG0561	phosphatase activity
AL464_RS11450	COG0602	queuosine metabolic process
AL464_RS11455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL464_RS11460	COG3706	GGDEF domain
AL464_RS11500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL464_RS11505	COG0840	transmembrane signaling receptor activity
AL464_RS11510	COG1254	Belongs to the acylphosphatase family
AL464_RS11515	COG2920	part of a sulfur-relay system
AL464_RS11525	COG0670	Belongs to the BI1 family
AL464_RS11530	COG1126	abc transporter atp-binding protein
AL464_RS11535	COG0765	amino acid transport
AL464_RS11540	COG4597	amino acid ABC transporter
AL464_RS11545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_RS11555	COG1666	GTP binding
AL464_RS11560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL464_RS11580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL464_RS11580	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AL464_RS11585	COG3008	intermembrane lipid transfer
AL464_RS11590	COG2995	paraquat-inducible protein a
AL464_RS11595	COG1132	(ABC) transporter
AL464_RS11600	COG1956	GAF domain-containing protein
AL464_RS11605	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL464_RS11620	COG0308	aminopeptidase N
AL464_RS11625	COG2902	Dehydrogenase
AL464_RS11630	COG0167	dihydroorotate dehydrogenase activity
AL464_RS11640	COG0116	Belongs to the methyltransferase superfamily
AL464_RS11640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL464_RS11650	COG0488	(ABC) transporter
AL464_RS11665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL464_RS11670	COG1067	ATP-dependent peptidase activity
AL464_RS11675	COG3120	sequence-specific DNA binding
AL464_RS11715	COG2205	protein histidine kinase activity
AL464_RS11715	COG0784	Response regulator, receiver
AL464_RS11730	COG3278	Belongs to the heme-copper respiratory oxidase family
AL464_RS11745	COG2010	Cytochrome c
AL464_RS11755	COG2217	Heavy metal translocating P-type atpase
AL464_RS11770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL464_RS11775	COG0589	response to stress
AL464_RS11780	COG0037	tRNA processing
AL464_RS11800	COG3842	ATPase activity
AL464_RS11810	COG1177	transmembrane transport
AL464_RS11820	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL464_RS11825	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL464_RS11835	COG0004	ammonium transporteR
AL464_RS11860	COG0437	4 iron, 4 sulfur cluster binding
AL464_RS11865	COG0243	molybdopterin cofactor binding
AL464_RS11865	COG3383	formate dehydrogenase (NAD+) activity
AL464_RS11875	COG3381	protein complex oligomerization
AL464_RS11895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL464_RS11900	COG0488	(ABC) transporter
AL464_RS11905	COG4191	Histidine kinase
AL464_RS11910	COG2204	response regulator
AL464_RS11925	COG3842	ATPase activity
AL464_RS11930	COG0746	molybdenum cofactor guanylyltransferase activity
AL464_RS11935	COG0303	'Molybdopterin
AL464_RS11945	COG1940	carbohydrate kinase activity
AL464_RS11950	COG3148	PFAM DTW domain containing protein
AL464_RS11985	COG0840	transmembrane signaling receptor activity
AL464_RS11990	COG0791	NLP P60 protein
AL464_RS12000	COG3706	GGDEF domain
AL464_RS12005	COG2201	protein-glutamate methylesterase activity
AL464_RS12010	COG3001	Fructosamine kinase
AL464_RS12020	COG0307	riboflavin synthase, alpha
AL464_RS12025	COG0534	Mate efflux family protein
AL464_RS12035	COG1793	dna ligase
AL464_RS12065	COG2204	response regulator
AL464_RS12075	COG0438	transferase activity, transferring glycosyl groups
AL464_RS12105	COG0438	transferase activity, transferring glycosyl groups
AL464_RS12110	COG1215	transferase activity, transferring glycosyl groups
AL464_RS12115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL464_RS12125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL464_RS12140	COG1643	Atp-dependent helicase
AL464_RS12145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL464_RS12160	COG3302	dmso reductase anchor subunit
AL464_RS12165	COG0437	4 iron, 4 sulfur cluster binding
AL464_RS12170	COG0243	molybdopterin cofactor binding
AL464_RS12200	COG3706	GGDEF domain
AL464_RS12210	COG0443	Heat shock 70 kDa protein
AL464_RS12215	COG0443	Heat shock 70 kDa protein
AL464_RS12240	COG1132	(ABC) transporter
AL464_RS12245	COG1132	(ABC) transporter
AL464_RS12265	COG0814	amino acid
AL464_RS12275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL464_RS12365	COG1522	sequence-specific DNA binding
AL464_RS12400	COG0515	serine threonine protein kinase
AL464_RS12425	COG3501	Rhs element vgr protein
AL464_RS12465	COG0739	heme binding
AL464_RS12470	COG0861	Integral membrane protein TerC family
AL464_RS12480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL464_RS12485	COG1328	CTP reductase activity
AL464_RS12490	COG1280	lysine exporter protein (LysE YggA)
AL464_RS12500	COG5001	Diguanylate cyclase
AL464_RS12500	COG3300	MHYT domain
AL464_RS12510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_RS12510	COG4191	Histidine kinase
AL464_RS12515	COG0471	metal ion transport
AL464_RS12550	COG0583	DNA-binding transcription factor activity
AL464_RS12615	COG0625	glutathione transferase activity
AL464_RS12625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL464_RS12640	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL464_RS12650	COG0601	transmembrane transport
AL464_RS12655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL464_RS12660	COG0444	Belongs to the ABC transporter superfamily
AL464_RS12680	COG3291	Pkd domain containing protein
AL464_RS12690	COG1177	transmembrane transport
AL464_RS12695	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL464_RS12700	COG3842	ATPase activity
AL464_RS12705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL464_RS12710	COG2423	ornithine cyclodeaminase activity
AL464_RS12725	COG3938	Belongs to the proline racemase family
AL464_RS12755	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AL464_RS12760	COG1451	nucleotide metabolic process
AL464_RS12765	COG3475	LICD family
AL464_RS12770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL464_RS12775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL464_RS12795	COG0583	DNA-binding transcription factor activity
AL464_RS12815	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL464_RS12820	COG4139	cobalamin transport
AL464_RS12825	COG2988	succinylglutamate desuccinylase activity
AL464_RS12835	COG2062	phosphohistidine phosphatase, SixA
AL464_RS12845	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL464_RS12850	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL464_RS12855	COG0702	epimerase
AL464_RS12860	COG1823	symporter activity
AL464_RS12865	COG2925	Exonuclease
AL464_RS12870	COG1380	Effector of murein hydrolase LrgA
AL464_RS12875	COG1346	cytolysis
AL464_RS12880	COG0295	cytidine deaminase activity
AL464_RS12885	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL464_RS12890	COG0500	methyltransferase
AL464_RS12900	COG0776	regulation of translation
AL464_RS12910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL464_RS12910	COG0072	phenylalanine-tRNA ligase activity
AL464_RS12915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL464_RS12920	COG3706	GGDEF domain
AL464_RS12950	COG0393	Putative heavy-metal-binding
AL464_RS12960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL464_RS12970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL464_RS12985	COG2188	Transcriptional regulator
AL464_RS12990	COG1228	amidohydrolase
AL464_RS12995	COG0010	Belongs to the arginase family
AL464_RS13000	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL464_RS13005	COG2986	histidine ammonia-lyase
AL464_RS13020	COG0277	FAD linked oxidase domain protein
AL464_RS13020	COG0247	lactate metabolic process
AL464_RS13055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL464_RS13070	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AL464_RS13075	COG1643	Atp-dependent helicase
AL464_RS13080	COG0281	malic enzyme
AL464_RS13085	COG2949	membrane
AL464_RS13090	COG0471	metal ion transport
AL464_RS13115	COG0492	ferredoxin-NADP+ reductase activity
AL464_RS13120	COG4988	ABC transporter
AL464_RS13125	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL464_RS13130	COG3048	D-serine ammonia-lyase activity
AL464_RS13135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL464_RS13145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_RS13145	COG4191	Histidine kinase
AL464_RS13160	COG3070	regulator of competence-specific genes
AL464_RS13175	COG2431	L-lysine efflux transmembrane transporter activity
AL464_RS13185	COG0076	glutamate decarboxylase activity
AL464_RS13190	COG1737	Transcriptional regulator
AL464_RS13200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL464_RS13205	COG3273	potassium ion transport
AL464_RS13205	COG2985	domain, Protein
AL464_RS13210	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL464_RS13225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL464_RS13240	COG4181	ATPase activity
AL464_RS13245	COG0534	Mate efflux family protein
AL464_RS13255	COG3005	denitrification pathway
AL464_RS13285	COG2814	Major facilitator Superfamily
AL464_RS13290	COG1187	pseudouridine synthase activity
AL464_RS13295	COG1061	Type III restriction enzyme res subunit
AL464_RS13315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL464_RS13340	COG3313	Fe-S protein
AL464_RS13365	COG0493	'glutamate synthase
AL464_RS13375	COG0398	Pfam SNARE associated Golgi protein
AL464_RS13380	COG4134	Bacterial extracellular solute-binding protein
AL464_RS13385	COG4135	transport system, permease component
AL464_RS13390	COG4136	ATPase activity
AL464_RS13395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL464_RS13405	COG3604	Transcriptional regulator
AL464_RS13410	COG1151	hydroxylamine reductase activity
AL464_RS13415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL464_RS13425	COG0564	pseudouridine synthase activity
AL464_RS13435	COG0733	neurotransmitter:sodium symporter activity
AL464_RS13445	COG0626	cystathionine gamma-synthase activity
AL464_RS13450	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL464_RS13455	COG5380	lipid catabolic process
AL464_RS13460	COG2818	Glycosylase
AL464_RS13475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_RS13490	COG1842	Phage shock protein A
AL464_RS13495	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL464_RS13510	COG4171	peptide transport system, permease
AL464_RS13520	COG4172	Belongs to the ABC transporter superfamily
AL464_RS13530	COG1227	inorganic diphosphatase activity
AL464_RS13545	COG0243	molybdopterin cofactor binding
AL464_RS13550	COG3005	denitrification pathway
AL464_RS13555	COG4459	periplasmic nitrate reductase
AL464_RS13560	COG0390	transport system, permease component
AL464_RS13565	COG2116	formate transmembrane transporter activity
AL464_RS13590	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL464_RS13595	COG1435	thymidine kinase activity
AL464_RS13600	COG0215	cysteine-tRNA ligase activity
AL464_RS13605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL464_RS13610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL464_RS13615	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL464_RS13620	COG3012	SEC-C Motif Domain Protein
AL464_RS13625	COG0140	phosphoribosyl-ATP diphosphatase activity
AL464_RS13625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL464_RS13630	COG0107	imidazoleglycerol-phosphate synthase activity
AL464_RS13635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL464_RS13640	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL464_RS13645	COG0131	Imidazoleglycerol-phosphate dehydratase
AL464_RS13645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL464_RS13650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL464_RS13655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL464_RS13660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL464_RS13675	COG1757	Na H antiporter
AL464_RS13685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL464_RS13695	COG0482	sulfurtransferase activity
AL464_RS13700	COG2915	High frequency lysogenization protein hflD homolog
AL464_RS13705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL464_RS13725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL464_RS13740	COG0300	oxidoreductase activity
AL464_RS13750	COG0501	Belongs to the peptidase M48B family
AL464_RS13755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL464_RS13765	COG0156	8-amino-7-oxononanoate synthase activity
AL464_RS13770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL464_RS13775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL464_RS13780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL464_RS13795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL464_RS13800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL464_RS13805	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL464_RS13810	COG1674	ftsk spoiiie
AL464_RS13820	COG0686	Belongs to the AlaDH PNT family
AL464_RS13830	COG0583	DNA-binding transcription factor activity
AL464_RS13845	COG3568	Endonuclease Exonuclease Phosphatase
AL464_RS13870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_RS13875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_RS13880	COG0840	transmembrane signaling receptor activity
AL464_RS13895	COG5002	protein histidine kinase activity
AL464_RS13895	COG0784	Response regulator, receiver
AL464_RS13905	COG0754	glutathionylspermidine amidase activity
AL464_RS13915	COG3766	membrane
AL464_RS13925	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL464_RS13930	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL464_RS13935	COG2885	chlorophyll binding
AL464_RS13940	COG0823	Involved in the tonB-independent uptake of proteins
AL464_RS13955	COG0811	peptide transport
AL464_RS13960	COG0824	Thioesterase
AL464_RS13970	COG4890	Cyd operon protein YbgT
AL464_RS13975	COG1294	oxidase, subunit
AL464_RS13980	COG1271	oxidase subunit
AL464_RS13985	COG2255	four-way junction helicase activity
AL464_RS13990	COG0632	four-way junction helicase activity
AL464_RS13995	COG0840	transmembrane signaling receptor activity
AL464_RS14000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL464_RS14005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL464_RS14010	COG1801	Protein of unknown function DUF72
AL464_RS14015	COG4106	trans-aconitate 2-methyltransferase activity
AL464_RS14020	COG0500	methyltransferase
AL464_RS14025	COG4067	protein conserved in archaea
AL464_RS14025	COG0189	ligase activity
AL464_RS14040	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL464_RS14045	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL464_RS14050	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL464_RS14055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL464_RS14060	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL464_RS14065	COG0745	RESPONSE REGULATOR receiver
AL464_RS14070	COG3381	protein complex oligomerization
AL464_RS14075	COG1609	Transcriptional regulator
AL464_RS14080	COG3070	regulator of competence-specific genes
AL464_RS14100	COG0297	glycogen (starch) synthase activity
AL464_RS14105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL464_RS14110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL464_RS14120	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL464_RS14130	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL464_RS14135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL464_RS14140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL464_RS14150	COG0542	response to heat
AL464_RS14155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL464_RS14160	COG1278	Cold shock
AL464_RS14170	COG1187	pseudouridine synthase activity
AL464_RS14175	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL464_RS14185	COG1199	ATP-dependent helicase activity
AL464_RS14190	COG0730	response to heat
AL464_RS14195	COG3923	Primosomal replication protein n
AL464_RS14205	COG0708	Exodeoxyribonuclease III
AL464_RS14245	COG1882	Formate acetyltransferase
AL464_RS14255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL464_RS14265	COG3013	Belongs to the UPF0304 family
AL464_RS14270	COG2766	serine protein kinase
AL464_RS14275	COG2718	Belongs to the UPF0229 family
AL464_RS14280	COG2719	SpoVR family
AL464_RS14285	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL464_RS14295	COG1663	tetraacyldisaccharide 4'-kinase activity
AL464_RS14300	COG1132	(ABC) transporter
AL464_RS14305	COG0658	competence protein
AL464_RS14305	COG2333	competence protein COMEC
AL464_RS14315	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL464_RS14320	COG1136	(ABC) transporter
AL464_RS14325	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL464_RS14335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL464_RS14350	COG1252	NADH dehydrogenase
AL464_RS14355	COG3150	esterase
AL464_RS14380	COG0537	adenosine 5'-monophosphoramidase activity
AL464_RS14405	COG0516	GMP reductase activity
AL464_RS14405	COG0517	IMP dehydrogenase activity
AL464_RS14410	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AL464_RS14415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL464_RS14420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL464_RS14430	COG2199	diguanylate cyclase activity
AL464_RS14445	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL464_RS14450	COG1946	Acyl-CoA thioesterase
AL464_RS14460	COG1522	sequence-specific DNA binding
AL464_RS14485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_RS14490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_RS14535	COG0477	Major facilitator Superfamily
AL464_RS14540	COG2855	membrane
AL464_RS14560	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL464_RS14565	COG0596	Alpha beta hydrolase
AL464_RS14575	COG1169	isochorismate synthase
AL464_RS14580	COG0436	Aminotransferase
AL464_RS14585	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL464_RS14590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL464_RS14605	COG1555	photosystem II stabilization
AL464_RS14610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL464_RS14615	COG0776	regulation of translation
AL464_RS14620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL464_RS14625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL464_RS14635	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL464_RS14650	COG2204	response regulator
AL464_RS14660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL464_RS14665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL464_RS14670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL464_RS14675	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL464_RS14690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL464_RS14695	COG0569	domain protein
AL464_RS14700	COG0513	Belongs to the DEAD box helicase family
AL464_RS14705	COG1253	flavin adenine dinucleotide binding
AL464_RS14740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL464_RS14745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL464_RS14760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL464_RS14765	COG1216	Glycosyl transferase, family 2
AL464_RS14770	COG2986	histidine ammonia-lyase
AL464_RS14795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL464_RS14805	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_RS14825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL464_RS14830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL464_RS14835	COG0583	DNA-binding transcription factor activity
AL464_RS14840	COG2951	lytic endotransglycosylase activity
AL464_RS14845	COG3100	YcgL domain-containing protein
AL464_RS14850	COG0850	regulation of cytokinetic process
AL464_RS14855	COG2894	cell division
AL464_RS14860	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL464_RS14865	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL464_RS14870	COG0318	PFAM AMP-dependent synthetase and ligase
AL464_RS14875	COG2267	carboxylic ester hydrolase activity
AL464_RS14890	COG1214	PFAM Peptidase M22, glycoprotease
AL464_RS14895	COG1199	ATP-dependent helicase activity
AL464_RS14900	COG0788	formyltetrahydrofolate deformylase activity
AL464_RS14905	COG3102	Protein conserved in bacteria
AL464_RS14910	COG0018	arginyl-trna synthetase
AL464_RS14930	COG1918	ferrous iron import across plasma membrane
AL464_RS14935	COG4977	sequence-specific DNA binding
AL464_RS14940	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL464_RS14945	COG1121	(ABC) transporter
AL464_RS14950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL464_RS14960	COG0045	succinate-CoA ligase (ADP-forming) activity
AL464_RS14965	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL464_RS14970	COG0567	Dehydrogenase, E1 component
AL464_RS14975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL464_RS14980	COG1053	succinate dehydrogenase
AL464_RS14985	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL464_RS15000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL464_RS15010	COG0033	Phosphoglucomutase
AL464_RS15015	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL464_RS15020	COG0596	Alpha beta hydrolase
AL464_RS15030	COG0716	FMN binding
AL464_RS15040	COG0735	belongs to the Fur family
AL464_RS15045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL464_RS15050	COG1263	PTS System
AL464_RS15050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL464_RS15055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL464_RS15060	COG1846	Transcriptional regulator
AL464_RS15060	COG1940	carbohydrate kinase activity
AL464_RS15065	COG4651	solute:proton antiporter activity
AL464_RS15065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL464_RS15070	COG0367	asparagine synthase
AL464_RS15075	COG0250	Participates in transcription elongation, termination and antitermination
AL464_RS15080	COG3104	oligopeptide transport
AL464_RS15085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL464_RS15090	COG0563	adenylate kinase activity
AL464_RS15095	COG0326	Molecular chaperone. Has ATPase activity
AL464_RS15100	COG3710	Transcriptional regulator
AL464_RS15120	COG0622	Phosphoesterase
AL464_RS15145	COG1090	epimerase
AL464_RS15150	COG0300	oxidoreductase activity
AL464_RS15155	COG3118	belongs to the thioredoxin family
AL464_RS15160	COG0330	HflC and HflK could
AL464_RS15180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL464_RS15185	COG3115	cell septum assembly
AL464_RS15190	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL464_RS15195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL464_RS15200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_RS15205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL464_RS15210	COG2190	(PTS) system
AL464_RS15215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_RS15220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_RS15325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL464_RS15460	COG1702	phosphate starvation-inducible protein PhoH
AL464_RS15595	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AL464_RS15710	COG1073	alpha beta
AL464_RS16455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL464_RS16525	COG4974	Belongs to the 'phage' integrase family
AL464_RS16560	COG1115	amino acid carrier protein
AL464_RS16655	COG0067	glutamate synthase
AL464_RS16655	COG0070	glutamate synthase
AL464_RS16655	COG0069	glutamate synthase activity
AL464_RS16660	COG0070	glutamate synthase
AL464_RS16660	COG0067	glutamate synthase
AL464_RS16660	COG0069	glutamate synthase activity
AL464_RS16695	COG0070	glutamate synthase
AL464_RS16695	COG0069	glutamate synthase activity
AL464_RS16695	COG0067	glutamate synthase
AL464_RS16700	COG0493	'glutamate synthase
AL464_RS16805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL464_RS16825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL464_RS16845	COG0275	rRNA processing
AL464_RS16890	COG0723	plastoquinol--plastocyanin reductase activity
AL464_RS16915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL464_RS17345	COG2911	Protein conserved in bacteria
AL464_RS17555	COG1494	fructose-1,6-bisphosphatase
AL464_RS17570	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL464_RS17835	COG4166	transmembrane transport
AL464_RS18090	COG1295	ribonuclease BN
AL464_RS18105	COG1217	gtp-binding protein TYPA
AL464_RS18460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_RS18510	COG0366	Alpha amylase catalytic
AL464_RS18690	COG0129	dihydroxy-acid dehydratase activity
AL464_RS18960	COG0248	Ppx GppA phosphatase
AL464_RS19115	COG0019	diaminopimelate decarboxylase activity
AL464_RS19135	COG3287	FIST C domain
AL464_RS19135	COG2200	EAL domain
AL464_RS19135	COG2199	diguanylate cyclase activity
AL464_RS19340	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL464_RS19340	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL464_RS19630	COG0646	methionine synthase
AL464_RS19630	COG1410	methionine synthase
AL464_RS19785	COG1530	ribonuclease E activity
AL464_RS19830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL464_RS19975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL464_RS19985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL464_RS20325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL464_RS20350	COG2205	protein histidine kinase activity
AL464_RS20375	COG0534	Mate efflux family protein
AL464_RS20545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL464_RS20595	COG0557	exoribonuclease II activity
AL464_RS20705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL464_RS21290	COG0681	Belongs to the peptidase S26 family
AL464_RS21315	COG4999	Histidine kinase
AL464_RS21315	COG2205	protein histidine kinase activity
AL464_RS21315	COG3437	response regulator, receiver
AL464_RS21315	COG3850	Histidine kinase
AL464_RS21430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL464_RS21600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL464_RS21675	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL464_RS21695	COG0004	ammonium transporteR
AL464_RS21825	COG0628	permease
AL464_RS22190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL464_RS22400	COG1805	sodium ion transport
AL464_RS22505	COG0442	prolyl-tRNA aminoacylation
AL464_RS22840	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL464_RS22975	COG1024	Enoyl-CoA hydratase
AL464_RS22975	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL464_RS23250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL464_RS23260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone