locus-tag	class	description
VPBB_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VPBB_RS00010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VPBB_RS00015	COG0706	membrane insertase activity
VPBB_RS00020	COG0594	ribonuclease P activity
VPBB_RS00030	COG1126	abc transporter atp-binding protein
VPBB_RS00045	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VPBB_RS00050	COG0592	DNA-directed DNA polymerase activity
VPBB_RS00055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VPBB_RS00060	COG0187	DNA topoisomerase II activity
VPBB_RS00070	COG0071	Belongs to the small heat shock protein (HSP20) family
VPBB_RS00075	COG3977	Valine--pyruvate aminotransferase
VPBB_RS00080	COG0366	Alpha amylase catalytic
VPBB_RS00085	COG0751	glycine-tRNA ligase activity
VPBB_RS00090	COG0752	glycyl-tRNA synthetase alpha subunit
VPBB_RS00095	COG2119	membrane
VPBB_RS00105	COG0425	Belongs to the sulfur carrier protein TusA family
VPBB_RS00120	COG0604	alcohol dehydrogenase
VPBB_RS00125	COG0183	Belongs to the thiolase family
VPBB_RS00130	COG1250	3-hydroxyacyl-CoA dehydrogenase
VPBB_RS00130	COG1024	Enoyl-CoA hydratase
VPBB_RS00135	COG1739	Uncharacterized protein family UPF0029
VPBB_RS00140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPBB_RS00180	COG0583	DNA-binding transcription factor activity
VPBB_RS00185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VPBB_RS00190	COG2960	long-chain fatty acid transporting porin activity
VPBB_RS00195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPBB_RS00200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_RS00255	COG4172	Belongs to the ABC transporter superfamily
VPBB_RS00260	COG0747	negative chemotaxis
VPBB_RS00265	COG0601	transmembrane transport
VPBB_RS00270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPBB_RS00305	COG1609	Transcriptional regulator
VPBB_RS00310	COG0583	DNA-binding transcription factor activity
VPBB_RS00325	COG0129	dihydroxy-acid dehydratase activity
VPBB_RS00330	COG3265	gluconokinase activity
VPBB_RS00335	COG2610	gluconate transmembrane transporter activity
VPBB_RS00340	COG0800	Aldolase
VPBB_RS00345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VPBB_RS00350	COG0583	DNA-binding transcription factor activity
VPBB_RS00355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPBB_RS00360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VPBB_RS00365	COG0339	signal peptide processing
VPBB_RS00370	COG1522	sequence-specific DNA binding
VPBB_RS00380	COG0742	ribosomal rna small subunit methyltransferase
VPBB_RS00395	COG0589	response to stress
VPBB_RS00400	COG1528	Iron-storage protein
VPBB_RS00410	COG2081	HI0933 family
VPBB_RS00420	COG2823	Periplasmic or secreted lipoprotein
VPBB_RS00440	COG1597	lipid kinase activity
VPBB_RS00470	COG0628	permease
VPBB_RS00485	COG1322	Protein conserved in bacteria
VPBB_RS00490	COG2226	methyltransferase
VPBB_RS00495	COG3165	ubiquinone biosynthetic process from chorismate
VPBB_RS00500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VPBB_RS00505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VPBB_RS00510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VPBB_RS00515	COG0805	protein transport
VPBB_RS00520	COG0084	hydrolase, TatD family'
VPBB_RS00535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPBB_RS00535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPBB_RS00540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VPBB_RS00570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VPBB_RS00580	COG2204	response regulator
VPBB_RS00585	COG3852	Histidine kinase
VPBB_RS00595	COG0174	glutamine synthetase
VPBB_RS00600	COG1217	gtp-binding protein TYPA
VPBB_RS00615	COG1295	ribonuclease BN
VPBB_RS00620	COG1490	D-aminoacyl-tRNA deacylase activity
VPBB_RS00625	COG0456	acetyltransferase
VPBB_RS00635	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VPBB_RS00640	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VPBB_RS00645	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VPBB_RS00650	COG3031	protein transport across the cell outer membrane
VPBB_RS00660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPBB_RS00665	COG1459	type II secretion system
VPBB_RS00670	COG2165	general secretion pathway protein
VPBB_RS00675	COG2165	general secretion pathway protein
VPBB_RS00680	COG2165	general secretion pathway protein
VPBB_RS00685	COG4795	General secretion pathway protein
VPBB_RS00690	COG3156	type II secretion system protein K
VPBB_RS00695	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VPBB_RS00700	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VPBB_RS00710	COG1218	3'(2'),5'-bisphosphate nucleotidase
VPBB_RS00715	COG0494	nUDIX hydrolase
VPBB_RS00720	COG0316	Belongs to the HesB IscA family
VPBB_RS00720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VPBB_RS00725	COG0596	Alpha beta hydrolase
VPBB_RS00735	COG2183	response to ionizing radiation
VPBB_RS00745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPBB_RS00765	COG2233	PERMEase
VPBB_RS00775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VPBB_RS00780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPBB_RS00785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VPBB_RS00790	COG1758	RNA polymerase activity
VPBB_RS00795	COG0194	GDP metabolic process
VPBB_RS00810	COG0848	biopolymer transport protein
VPBB_RS00815	COG0811	peptide transport
VPBB_RS00835	COG4174	ABC transporter (Permease)
VPBB_RS00840	COG4239	(ABC) transporter, permease
VPBB_RS00845	COG0747	negative chemotaxis
VPBB_RS00850	COG0444	Belongs to the ABC transporter superfamily
VPBB_RS00855	COG4608	Belongs to the ABC transporter superfamily
VPBB_RS00890	COG0328	RNA-DNA hybrid ribonuclease activity
VPBB_RS00930	COG2003	Belongs to the UPF0758 family
VPBB_RS00950	COG1561	YicC-like family, N-terminal region
VPBB_RS00955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VPBB_RS00960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VPBB_RS00965	COG1560	Kdo2-lipid A biosynthetic process
VPBB_RS00970	COG1309	transcriptional regulator
VPBB_RS00975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VPBB_RS00980	COG0840	transmembrane signaling receptor activity
VPBB_RS00985	COG2003	Belongs to the UPF0758 family
VPBB_RS00990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VPBB_RS01000	COG2194	sulfuric ester hydrolase activity
VPBB_RS01010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VPBB_RS01015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VPBB_RS01030	COG0463	Glycosyl transferase, family 2
VPBB_RS01035	COG0859	PFAM glycosyl transferase family 9
VPBB_RS01040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VPBB_RS01045	COG3642	lipopolysaccharide core region biosynthetic process
VPBB_RS01055	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
VPBB_RS01105	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_RS01115	COG1519	Transferase
VPBB_RS01135	COG1560	Kdo2-lipid A biosynthetic process
VPBB_RS01145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPBB_RS01180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VPBB_RS01185	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VPBB_RS01200	COG0438	transferase activity, transferring glycosyl groups
VPBB_RS01205	COG0438	transferase activity, transferring glycosyl groups
VPBB_RS01220	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VPBB_RS01225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VPBB_RS01245	COG1482	cell wall glycoprotein biosynthetic process
VPBB_RS01260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VPBB_RS01285	COG0149	triose-phosphate isomerase activity
VPBB_RS01310	COG1494	fructose-1,6-bisphosphatase
VPBB_RS01315	COG3074	FtsZ-dependent cytokinesis
VPBB_RS01320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VPBB_RS01325	COG1575	Belongs to the MenA family. Type 1 subfamily
VPBB_RS01330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VPBB_RS01335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VPBB_RS01345	COG1609	Transcriptional regulator
VPBB_RS01350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VPBB_RS01355	COG0254	rRNA binding
VPBB_RS01365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VPBB_RS01370	COG0088	Forms part of the polypeptide exit tunnel
VPBB_RS01380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VPBB_RS01385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VPBB_RS01395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VPBB_RS01405	COG0255	Belongs to the universal ribosomal protein uL29 family
VPBB_RS01410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VPBB_RS01415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VPBB_RS01420	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VPBB_RS01425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VPBB_RS01430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VPBB_RS01435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VPBB_RS01440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VPBB_RS01455	COG1841	ribosomal large subunit assembly
VPBB_RS01460	COG0200	Binds to the 23S rRNA
VPBB_RS01465	COG0201	protein transport
VPBB_RS01470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VPBB_RS01475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VPBB_RS01480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VPBB_RS01490	COG0202	RNA polymerase activity
VPBB_RS01495	COG0203	ribosomal protein L17
VPBB_RS01505	COG0545	Peptidyl-prolyl cis-trans isomerase
VPBB_RS01515	COG2153	protein acetylation
VPBB_RS01520	COG0513	Belongs to the DEAD box helicase family
VPBB_RS01530	COG0737	Belongs to the 5'-nucleotidase family
VPBB_RS01535	COG1648	precorrin-2 dehydrogenase activity
VPBB_RS01535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VPBB_RS01540	COG0175	sulfate reduction
VPBB_RS01545	COG2895	sulfate adenylyltransferase (ATP) activity
VPBB_RS01550	COG3273	potassium ion transport
VPBB_RS01550	COG0471	metal ion transport
VPBB_RS01555	COG0529	Catalyzes the synthesis of activated sulfate
VPBB_RS01575	COG4181	ATPase activity
VPBB_RS01590	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VPBB_RS01600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPBB_RS01605	COG0729	surface antigen
VPBB_RS01615	COG2105	PFAM AIG2 family protein
VPBB_RS01625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VPBB_RS01630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VPBB_RS01635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VPBB_RS01640	COG0163	prenyltransferase activity
VPBB_RS01645	COG4143	(ABC) transporter
VPBB_RS01650	COG1178	ABC-type Fe3 transport system permease component
VPBB_RS01655	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VPBB_RS01670	COG2358	TRAP transporter, solute receptor (TAXI family
VPBB_RS01680	COG0039	L-malate dehydrogenase activity
VPBB_RS01690	COG0142	geranyltranstransferase activity
VPBB_RS01695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VPBB_RS01705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VPBB_RS01710	COG2966	Psort location CytoplasmicMembrane, score
VPBB_RS01725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VPBB_RS01730	COG2967	ApaG domain
VPBB_RS01735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VPBB_RS01740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VPBB_RS01745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VPBB_RS01750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VPBB_RS01755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VPBB_RS01765	COG0066	3-isopropylmalate dehydratase activity
VPBB_RS01770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VPBB_RS01775	COG0473	3-isopropylmalate dehydrogenase activity
VPBB_RS01780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VPBB_RS01800	COG0583	DNA-binding transcription factor activity
VPBB_RS01805	COG1022	Amp-dependent synthetase and ligase
VPBB_RS01810	COG0028	Belongs to the TPP enzyme family
VPBB_RS01815	COG0440	acetolactate synthase activity
VPBB_RS01830	COG0469	pyruvate kinase activity
VPBB_RS01835	COG1349	DNA-binding transcription factor activity
VPBB_RS01840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VPBB_RS01855	COG5002	protein histidine kinase activity
VPBB_RS01865	COG2376	Dihydroxyacetone kinase
VPBB_RS01870	COG1461	Dihydroxyacetone kinase
VPBB_RS01885	COG3722	fumarate hydratase activity
VPBB_RS01890	COG0246	Mannitol dehydrogenase
VPBB_RS01895	COG2213	PTS system mannitol-specific
VPBB_RS01895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_RS01925	COG2207	Transcriptional regulator
VPBB_RS01935	COG1464	Belongs to the NlpA lipoprotein family
VPBB_RS01950	COG0358	DNA primase activity
VPBB_RS01955	COG1610	YqeY-like protein
VPBB_RS01960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VPBB_RS01965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VPBB_RS01970	COG0596	Alpha beta hydrolase
VPBB_RS01975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VPBB_RS01980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VPBB_RS01985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VPBB_RS01990	COG1968	undecaprenyl-diphosphatase activity
VPBB_RS01995	COG0617	tRNA 3'-terminal CCA addition
VPBB_RS02000	COG3409	Peptidoglycan-binding domain 1 protein
VPBB_RS02000	COG3267	Type II secretory pathway component ExeA
VPBB_RS02010	COG4991	sh3 domain protein
VPBB_RS02015	COG0306	phosphate transporter
VPBB_RS02020	COG1392	Phosphate transport regulator
VPBB_RS02025	COG3025	triphosphatase activity
VPBB_RS02040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VPBB_RS02045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VPBB_RS02045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VPBB_RS02050	COG1538	Outer membrane efflux protein
VPBB_RS02055	COG0494	nUDIX hydrolase
VPBB_RS02060	COG3151	Protein conserved in bacteria
VPBB_RS02070	COG3150	esterase
VPBB_RS02085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VPBB_RS02095	COG3105	Protein conserved in bacteria
VPBB_RS02100	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VPBB_RS02105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VPBB_RS02110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VPBB_RS02115	COG0723	plastoquinol--plastocyanin reductase activity
VPBB_RS02120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VPBB_RS02125	COG2857	Cytochrome c1
VPBB_RS02130	COG0625	glutathione transferase activity
VPBB_RS02135	COG2969	positive regulation of protein catabolic process
VPBB_RS02140	COG2823	Periplasmic or secreted lipoprotein
VPBB_RS02145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VPBB_RS02150	COG0792	nuclease activity
VPBB_RS02160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VPBB_RS02165	COG0275	rRNA processing
VPBB_RS02170	COG3116	cell division
VPBB_RS02175	COG0768	penicillin binding
VPBB_RS02180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VPBB_RS02185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VPBB_RS02190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VPBB_RS02195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VPBB_RS02200	COG0772	Belongs to the SEDS family
VPBB_RS02205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VPBB_RS02210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VPBB_RS02215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VPBB_RS02220	COG0849	cell division
VPBB_RS02225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VPBB_RS02230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VPBB_RS02240	COG0653	protein targeting
VPBB_RS02245	COG0494	nUDIX hydrolase
VPBB_RS02250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VPBB_RS02255	COG0505	Belongs to the CarA family
VPBB_RS02260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VPBB_RS02275	COG0730	response to heat
VPBB_RS02280	COG0583	DNA-binding transcription factor activity
VPBB_RS02285	COG2860	membrane
VPBB_RS02290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VPBB_RS02300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VPBB_RS02310	COG0493	'glutamate synthase
VPBB_RS02315	COG0070	glutamate synthase
VPBB_RS02315	COG0069	glutamate synthase activity
VPBB_RS02315	COG0067	glutamate synthase
VPBB_RS02325	COG0069	glutamate synthase activity
VPBB_RS02325	COG0067	glutamate synthase
VPBB_RS02325	COG0070	glutamate synthase
VPBB_RS02330	COG1242	4 iron, 4 sulfur cluster binding
VPBB_RS02335	COG2203	Gaf domain
VPBB_RS02335	COG3706	GGDEF domain
VPBB_RS02335	COG5001	Diguanylate cyclase
VPBB_RS02335	COG4251	negative regulation of phosphorylation
VPBB_RS02340	COG2198	Histidine kinase
VPBB_RS02340	COG0784	Response regulator, receiver
VPBB_RS02340	COG5002	protein histidine kinase activity
VPBB_RS02350	COG0745	RESPONSE REGULATOR receiver
VPBB_RS02360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VPBB_RS02375	COG0083	homoserine kinase activity
VPBB_RS02380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VPBB_RS02385	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VPBB_RS02390	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VPBB_RS02395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VPBB_RS02410	COG1115	amino acid carrier protein
VPBB_RS02415	COG3022	response to hydroperoxide
VPBB_RS02420	COG0513	Belongs to the DEAD box helicase family
VPBB_RS02425	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VPBB_RS02435	COG0716	FMN binding
VPBB_RS02440	COG4974	Belongs to the 'phage' integrase family
VPBB_RS02445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPBB_RS02450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VPBB_RS02455	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VPBB_RS02460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VPBB_RS02475	COG0667	Aldo Keto reductase
VPBB_RS02485	COG3066	DNA modification
VPBB_RS02490	COG0494	nUDIX hydrolase
VPBB_RS02500	COG0730	response to heat
VPBB_RS02505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VPBB_RS02510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VPBB_RS02520	COG1283	sodium-dependent phosphate transmembrane transporter activity
VPBB_RS02525	COG0583	DNA-binding transcription factor activity
VPBB_RS02530	COG0640	Transcriptional regulator
VPBB_RS02535	COG0268	Binds directly to 16S ribosomal RNA
VPBB_RS02540	COG0728	peptidoglycan biosynthetic process
VPBB_RS02545	COG0196	riboflavin kinase activity
VPBB_RS02550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VPBB_RS02555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VPBB_RS02560	COG1047	Peptidyl-prolyl cis-trans
VPBB_RS02565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VPBB_RS02570	COG3279	Response regulator of the LytR AlgR family
VPBB_RS02575	COG3275	phosphorelay sensor kinase activity
VPBB_RS02580	COG1966	Carbon starvation protein
VPBB_RS02595	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VPBB_RS02600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VPBB_RS02605	COG1472	Belongs to the glycosyl hydrolase 3 family
VPBB_RS02610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VPBB_RS02615	COG0287	Prephenate dehydrogenase
VPBB_RS02615	COG1605	Chorismate mutase
VPBB_RS02620	COG0739	heme binding
VPBB_RS02630	COG0488	(ABC) transporter
VPBB_RS02640	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VPBB_RS02645	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VPBB_RS02650	COG0077	Prephenate dehydratase
VPBB_RS02650	COG1605	Chorismate mutase
VPBB_RS02655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VPBB_RS02660	COG0741	lytic transglycosylase activity
VPBB_RS02665	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPBB_RS02670	COG0564	pseudouridine synthase activity
VPBB_RS02675	COG1496	oxidoreductase activity
VPBB_RS02680	COG0542	response to heat
VPBB_RS02735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VPBB_RS02740	COG0826	peptidase U32
VPBB_RS02745	COG2974	May be involved in recombination
VPBB_RS02750	COG0745	RESPONSE REGULATOR receiver
VPBB_RS02755	COG5002	protein histidine kinase activity
VPBB_RS02765	COG0248	Ppx GppA phosphatase
VPBB_RS02770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VPBB_RS02780	COG0581	inorganic phosphate transmembrane transporter activity
VPBB_RS02785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VPBB_RS02790	COG0704	Plays a role in the regulation of phosphate uptake
VPBB_RS02800	COG3142	Participates in the control of copper homeostasis
VPBB_RS02805	COG0450	alkyl hydroperoxide reductase
VPBB_RS02810	COG0583	DNA-binding transcription factor activity
VPBB_RS02815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VPBB_RS02825	COG0517	IMP dehydrogenase activity
VPBB_RS02835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VPBB_RS02840	COG0343	queuine tRNA-ribosyltransferase activity
VPBB_RS02845	COG1862	Preprotein translocase
VPBB_RS02850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPBB_RS02855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPBB_RS02860	COG0483	inositol monophosphate 1-phosphatase activity
VPBB_RS02875	COG1104	cysteine desulfurase activity
VPBB_RS02880	COG0822	iron-sulfur transferase activity
VPBB_RS02890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VPBB_RS02895	COG0443	Heat shock 70 kDa protein
VPBB_RS02900	COG0633	Ferredoxin
VPBB_RS02905	COG2975	iron-sulfur cluster assembly
VPBB_RS02910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VPBB_RS02915	COG0105	UTP biosynthetic process
VPBB_RS02920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VPBB_RS02930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VPBB_RS02935	COG0124	histidyl-tRNA synthetase
VPBB_RS02940	COG2976	Protein conserved in bacteria
VPBB_RS02945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPBB_RS02950	COG1160	GTP binding
VPBB_RS02965	COG1570	exodeoxyribonuclease VII activity
VPBB_RS02970	COG0516	GMP reductase activity
VPBB_RS02970	COG0517	IMP dehydrogenase activity
VPBB_RS02975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VPBB_RS02975	COG0519	Catalyzes the synthesis of GMP from XMP
VPBB_RS02980	COG1757	Na H antiporter
VPBB_RS02990	COG1584	GPR1 FUN34 yaaH family protein
VPBB_RS03000	COG1115	amino acid carrier protein
VPBB_RS03030	COG2873	o-acetylhomoserine
VPBB_RS03035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VPBB_RS03055	COG3153	acetyltransferase
VPBB_RS03055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VPBB_RS03060	COG0583	DNA-binding transcription factor activity
VPBB_RS03075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VPBB_RS03105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VPBB_RS03110	COG2867	negative regulation of translational initiation
VPBB_RS03115	COG2914	Belongs to the UPF0125 (RnfH) family
VPBB_RS03120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPBB_RS03125	COG0497	DNA recombination
VPBB_RS03135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VPBB_RS03140	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VPBB_RS03150	COG0443	Heat shock 70 kDa protein
VPBB_RS03155	COG0484	heat shock protein binding
VPBB_RS03165	COG4969	Belongs to the N-Me-Phe pilin family
VPBB_RS03185	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VPBB_RS03195	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VPBB_RS03200	COG0047	phosphoribosylformylglycinamidine synthase activity
VPBB_RS03200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VPBB_RS03225	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPBB_RS03230	COG2252	PERMEase
VPBB_RS03235	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VPBB_RS03240	COG1073	alpha beta
VPBB_RS03250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VPBB_RS03255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VPBB_RS03260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VPBB_RS03265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPBB_RS03265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPBB_RS03285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VPBB_RS03290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VPBB_RS03295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VPBB_RS03300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VPBB_RS03305	COG0142	geranyltranstransferase activity
VPBB_RS03310	COG1722	exodeoxyribonuclease VII activity
VPBB_RS03315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VPBB_RS03320	COG2885	chlorophyll binding
VPBB_RS03325	COG0301	tRNA thio-modification
VPBB_RS03325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPBB_RS03330	COG0583	DNA-binding transcription factor activity
VPBB_RS03340	COG2363	Small membrane protein
VPBB_RS03345	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VPBB_RS03355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPBB_RS03360	COG1611	Belongs to the LOG family
VPBB_RS03375	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VPBB_RS03375	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VPBB_RS03385	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VPBB_RS03390	COG1464	Belongs to the NlpA lipoprotein family
VPBB_RS03395	COG2011	ABC-type metal ion transport system permease component
VPBB_RS03400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VPBB_RS03405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VPBB_RS03415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPBB_RS03415	COG1263	PTS System
VPBB_RS03420	COG0366	Alpha amylase catalytic
VPBB_RS03435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VPBB_RS03440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VPBB_RS03445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VPBB_RS03450	COG0321	lipoyl(octanoyl) transferase activity
VPBB_RS03455	COG2921	Belongs to the UPF0250 family
VPBB_RS03460	COG1686	Belongs to the peptidase S11 family
VPBB_RS03465	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VPBB_RS03470	COG0772	Belongs to the SEDS family
VPBB_RS03475	COG0768	penicillin binding
VPBB_RS03480	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VPBB_RS03485	COG0799	negative regulation of ribosome biogenesis
VPBB_RS03490	COG1466	dna polymerase III delta subunit
VPBB_RS03495	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VPBB_RS03500	COG0495	leucyl-tRNA aminoacylation
VPBB_RS03505	COG2888	peptidyl-tyrosine sulfation
VPBB_RS03510	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VPBB_RS03515	COG4535	Mg2 and Co2 transporter CorC
VPBB_RS03520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VPBB_RS03525	COG1702	phosphate starvation-inducible protein PhoH
VPBB_RS03530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VPBB_RS03535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPBB_RS03640	COG0012	GTP binding
VPBB_RS03645	COG0193	aminoacyl-tRNA hydrolase activity
VPBB_RS03650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VPBB_RS03655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VPBB_RS03660	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VPBB_RS03665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VPBB_RS03670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VPBB_RS03675	COG2890	protein-(glutamine-N5) methyltransferase activity
VPBB_RS03680	COG3094	Invasion gene expression up-regulator, SirB
VPBB_RS03685	COG2912	Transglutaminase-like superfamily
VPBB_RS03690	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VPBB_RS03695	COG0737	Belongs to the 5'-nucleotidase family
VPBB_RS03705	COG1187	pseudouridine synthase activity
VPBB_RS03710	COG2840	Smr protein MutS2
VPBB_RS03745	COG2608	mercury ion transmembrane transporter activity
VPBB_RS03745	COG2217	Heavy metal translocating P-type atpase
VPBB_RS03755	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VPBB_RS03760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPBB_RS03810	COG0835	chemotaxis
VPBB_RS03810	COG0784	Response regulator, receiver
VPBB_RS03815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VPBB_RS03820	COG1815	bacterial-type flagellum-dependent cell motility
VPBB_RS03825	COG1558	bacterial-type flagellum-dependent cell motility
VPBB_RS03835	COG1749	Flagellar hook protein flgE
VPBB_RS03840	COG4787	bacterial-type flagellum-dependent cell motility
VPBB_RS03850	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VPBB_RS03855	COG1706	bacterial-type flagellum-dependent cell motility
VPBB_RS03860	COG3951	Flagellar rod assembly protein muramidase FlgJ
VPBB_RS03860	COG1705	Flagellar rod assembly protein muramidase FlgJ
VPBB_RS03870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_RS03875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_RS03880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_RS03885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_RS03890	COG2190	(PTS) system
VPBB_RS03895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VPBB_RS03900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_RS03905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VPBB_RS03910	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VPBB_RS03915	COG3115	cell septum assembly
VPBB_RS03920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VPBB_RS03935	COG0330	HflC and HflK could
VPBB_RS03940	COG3118	belongs to the thioredoxin family
VPBB_RS03945	COG0300	oxidoreductase activity
VPBB_RS03950	COG1090	epimerase
VPBB_RS03975	COG0622	Phosphoesterase
VPBB_RS03995	COG3710	Transcriptional regulator
VPBB_RS04000	COG0326	Molecular chaperone. Has ATPase activity
VPBB_RS04005	COG0563	adenylate kinase activity
VPBB_RS04010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VPBB_RS04015	COG3104	oligopeptide transport
VPBB_RS04020	COG0250	Participates in transcription elongation, termination and antitermination
VPBB_RS04025	COG0367	asparagine synthase
VPBB_RS04030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VPBB_RS04030	COG4651	solute:proton antiporter activity
VPBB_RS04035	COG1940	carbohydrate kinase activity
VPBB_RS04035	COG1846	Transcriptional regulator
VPBB_RS04040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VPBB_RS04045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPBB_RS04045	COG1263	PTS System
VPBB_RS04050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPBB_RS04055	COG0735	belongs to the Fur family
VPBB_RS04065	COG0716	FMN binding
VPBB_RS04075	COG0596	Alpha beta hydrolase
VPBB_RS04080	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VPBB_RS04085	COG0033	Phosphoglucomutase
VPBB_RS04095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VPBB_RS04110	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VPBB_RS04115	COG1053	succinate dehydrogenase
VPBB_RS04120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VPBB_RS04125	COG0567	Dehydrogenase, E1 component
VPBB_RS04130	COG0508	dehydrogenase complex catalyzes the overall conversion of
VPBB_RS04135	COG0045	succinate-CoA ligase (ADP-forming) activity
VPBB_RS04145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VPBB_RS04150	COG1121	(ABC) transporter
VPBB_RS04155	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VPBB_RS04160	COG4977	sequence-specific DNA binding
VPBB_RS04165	COG1918	ferrous iron import across plasma membrane
VPBB_RS04185	COG0018	arginyl-trna synthetase
VPBB_RS04190	COG3102	Protein conserved in bacteria
VPBB_RS04195	COG0788	formyltetrahydrofolate deformylase activity
VPBB_RS04200	COG1199	ATP-dependent helicase activity
VPBB_RS04205	COG1214	PFAM Peptidase M22, glycoprotease
VPBB_RS04220	COG2267	carboxylic ester hydrolase activity
VPBB_RS04225	COG0318	PFAM AMP-dependent synthetase and ligase
VPBB_RS04230	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VPBB_RS04235	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VPBB_RS04240	COG2894	cell division
VPBB_RS04245	COG0850	regulation of cytokinetic process
VPBB_RS04250	COG3100	YcgL domain-containing protein
VPBB_RS04255	COG2951	lytic endotransglycosylase activity
VPBB_RS04260	COG0583	DNA-binding transcription factor activity
VPBB_RS04265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VPBB_RS04270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VPBB_RS04300	COG1122	ATPase activity
VPBB_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_RS04325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VPBB_RS04350	COG2986	histidine ammonia-lyase
VPBB_RS04355	COG1216	Glycosyl transferase, family 2
VPBB_RS04360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPBB_RS04375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VPBB_RS04380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VPBB_RS04415	COG1253	flavin adenine dinucleotide binding
VPBB_RS04420	COG0513	Belongs to the DEAD box helicase family
VPBB_RS04425	COG0569	domain protein
VPBB_RS04430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPBB_RS04445	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VPBB_RS04450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VPBB_RS04455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VPBB_RS04460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VPBB_RS04470	COG2204	response regulator
VPBB_RS04485	COG0544	peptidyl-prolyl cis-trans isomerase activity
VPBB_RS04495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VPBB_RS04500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VPBB_RS04505	COG0776	regulation of translation
VPBB_RS04510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VPBB_RS04515	COG1555	photosystem II stabilization
VPBB_RS04530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VPBB_RS04535	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VPBB_RS04540	COG0436	Aminotransferase
VPBB_RS04545	COG1169	isochorismate synthase
VPBB_RS04550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VPBB_RS04555	COG0596	Alpha beta hydrolase
VPBB_RS04560	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VPBB_RS04580	COG2855	membrane
VPBB_RS04585	COG0477	Major facilitator Superfamily
VPBB_RS04625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPBB_RS04650	COG1522	sequence-specific DNA binding
VPBB_RS04660	COG1946	Acyl-CoA thioesterase
VPBB_RS04665	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VPBB_RS04680	COG2199	diguanylate cyclase activity
VPBB_RS04685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPBB_RS04690	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VPBB_RS04695	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VPBB_RS04700	COG0516	GMP reductase activity
VPBB_RS04700	COG0517	IMP dehydrogenase activity
VPBB_RS04725	COG0537	adenosine 5'-monophosphoramidase activity
VPBB_RS04750	COG3150	esterase
VPBB_RS04755	COG1252	NADH dehydrogenase
VPBB_RS04770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VPBB_RS04780	COG4591	ABC-type transport system involved in lipoprotein release permease component
VPBB_RS04785	COG1136	(ABC) transporter
VPBB_RS04790	COG4591	ABC-type transport system involved in lipoprotein release permease component
VPBB_RS04800	COG0658	competence protein
VPBB_RS04800	COG2333	competence protein COMEC
VPBB_RS04805	COG1132	(ABC) transporter
VPBB_RS04810	COG1663	tetraacyldisaccharide 4'-kinase activity
VPBB_RS04820	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VPBB_RS04825	COG2719	SpoVR family
VPBB_RS04830	COG2718	Belongs to the UPF0229 family
VPBB_RS04835	COG2766	serine protein kinase
VPBB_RS04840	COG3013	Belongs to the UPF0304 family
VPBB_RS04850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPBB_RS04860	COG1882	Formate acetyltransferase
VPBB_RS04900	COG0708	Exodeoxyribonuclease III
VPBB_RS04910	COG3923	Primosomal replication protein n
VPBB_RS04915	COG0730	response to heat
VPBB_RS04920	COG1199	ATP-dependent helicase activity
VPBB_RS04930	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VPBB_RS04935	COG1187	pseudouridine synthase activity
VPBB_RS04945	COG1278	Cold shock
VPBB_RS04950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VPBB_RS04955	COG0542	response to heat
VPBB_RS04965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VPBB_RS04970	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VPBB_RS04975	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VPBB_RS04985	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VPBB_RS04995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPBB_RS05000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VPBB_RS05005	COG0297	glycogen (starch) synthase activity
VPBB_RS05025	COG3070	regulator of competence-specific genes
VPBB_RS05030	COG1609	Transcriptional regulator
VPBB_RS05035	COG3381	protein complex oligomerization
VPBB_RS05040	COG0745	RESPONSE REGULATOR receiver
VPBB_RS05045	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VPBB_RS05050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VPBB_RS05055	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VPBB_RS05060	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VPBB_RS05065	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VPBB_RS05080	COG4067	protein conserved in archaea
VPBB_RS05080	COG0189	ligase activity
VPBB_RS05085	COG0500	methyltransferase
VPBB_RS05090	COG4106	trans-aconitate 2-methyltransferase activity
VPBB_RS05095	COG1801	Protein of unknown function DUF72
VPBB_RS05100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VPBB_RS05105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VPBB_RS05110	COG0840	transmembrane signaling receptor activity
VPBB_RS05115	COG0632	four-way junction helicase activity
VPBB_RS05120	COG2255	four-way junction helicase activity
VPBB_RS05125	COG1271	oxidase subunit
VPBB_RS05130	COG1294	oxidase, subunit
VPBB_RS05145	COG0824	Thioesterase
VPBB_RS05150	COG0811	peptide transport
VPBB_RS05165	COG0823	Involved in the tonB-independent uptake of proteins
VPBB_RS05170	COG2885	chlorophyll binding
VPBB_RS05175	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VPBB_RS05180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VPBB_RS05190	COG3766	membrane
VPBB_RS05200	COG0754	glutathionylspermidine amidase activity
VPBB_RS05210	COG0784	Response regulator, receiver
VPBB_RS05210	COG5002	protein histidine kinase activity
VPBB_RS05225	COG0840	transmembrane signaling receptor activity
VPBB_RS05230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_RS05235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPBB_RS05260	COG3568	Endonuclease Exonuclease Phosphatase
VPBB_RS05275	COG0583	DNA-binding transcription factor activity
VPBB_RS05285	COG0686	Belongs to the AlaDH PNT family
VPBB_RS05295	COG1674	ftsk spoiiie
VPBB_RS05300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VPBB_RS05305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VPBB_RS05310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VPBB_RS05325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VPBB_RS05330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VPBB_RS05335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VPBB_RS05340	COG0156	8-amino-7-oxononanoate synthase activity
VPBB_RS05350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VPBB_RS05355	COG0501	Belongs to the peptidase M48B family
VPBB_RS05365	COG0300	oxidoreductase activity
VPBB_RS05380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VPBB_RS05400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VPBB_RS05405	COG2915	High frequency lysogenization protein hflD homolog
VPBB_RS05410	COG0482	sulfurtransferase activity
VPBB_RS05420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPBB_RS05430	COG1757	Na H antiporter
VPBB_RS05445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VPBB_RS05450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VPBB_RS05455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VPBB_RS05460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VPBB_RS05460	COG0131	Imidazoleglycerol-phosphate dehydratase
VPBB_RS05465	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VPBB_RS05470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VPBB_RS05475	COG0107	imidazoleglycerol-phosphate synthase activity
VPBB_RS05480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VPBB_RS05480	COG0140	phosphoribosyl-ATP diphosphatase activity
VPBB_RS05485	COG3012	SEC-C Motif Domain Protein
VPBB_RS05490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VPBB_RS05495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPBB_RS05500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VPBB_RS05505	COG0215	cysteine-tRNA ligase activity
VPBB_RS05510	COG1435	thymidine kinase activity
VPBB_RS05515	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VPBB_RS05540	COG2116	formate transmembrane transporter activity
VPBB_RS05545	COG0390	transport system, permease component
VPBB_RS05550	COG4459	periplasmic nitrate reductase
VPBB_RS05555	COG3005	denitrification pathway
VPBB_RS05560	COG0243	molybdopterin cofactor binding
VPBB_RS05575	COG1227	inorganic diphosphatase activity
VPBB_RS05585	COG4172	Belongs to the ABC transporter superfamily
VPBB_RS05595	COG4171	peptide transport system, permease
VPBB_RS05610	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VPBB_RS05615	COG1842	Phage shock protein A
VPBB_RS05625	COG1983	PspC domain protein
VPBB_RS05630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_RS05645	COG2818	Glycosylase
VPBB_RS05650	COG5380	lipid catabolic process
VPBB_RS05655	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VPBB_RS05660	COG0626	cystathionine gamma-synthase activity
VPBB_RS05670	COG0733	neurotransmitter:sodium symporter activity
VPBB_RS05680	COG0564	pseudouridine synthase activity
VPBB_RS05690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VPBB_RS05695	COG1151	hydroxylamine reductase activity
VPBB_RS05700	COG3604	Transcriptional regulator
VPBB_RS05710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VPBB_RS05715	COG4136	ATPase activity
VPBB_RS05720	COG4135	transport system, permease component
VPBB_RS05725	COG4134	Bacterial extracellular solute-binding protein
VPBB_RS05730	COG0398	Pfam SNARE associated Golgi protein
VPBB_RS05740	COG0493	'glutamate synthase
VPBB_RS05765	COG3313	Fe-S protein
VPBB_RS05775	COG0737	Belongs to the 5'-nucleotidase family
VPBB_RS05790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VPBB_RS05810	COG1061	Type III restriction enzyme res subunit
VPBB_RS05815	COG1187	pseudouridine synthase activity
VPBB_RS05820	COG2814	Major facilitator Superfamily
VPBB_RS05850	COG3005	denitrification pathway
VPBB_RS05855	COG0702	epimerase
VPBB_RS05860	COG0534	Mate efflux family protein
VPBB_RS05865	COG4181	ATPase activity
VPBB_RS05880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPBB_RS05895	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VPBB_RS05900	COG2985	domain, Protein
VPBB_RS05900	COG3273	potassium ion transport
VPBB_RS05905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VPBB_RS05915	COG1737	Transcriptional regulator
VPBB_RS05920	COG0076	glutamate decarboxylase activity
VPBB_RS05930	COG2431	L-lysine efflux transmembrane transporter activity
VPBB_RS05940	COG3070	regulator of competence-specific genes
VPBB_RS05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_RS05955	COG4191	Histidine kinase
VPBB_RS05965	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VPBB_RS05970	COG3048	D-serine ammonia-lyase activity
VPBB_RS05975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VPBB_RS05980	COG4988	ABC transporter
VPBB_RS05985	COG0492	ferredoxin-NADP+ reductase activity
VPBB_RS06010	COG0471	metal ion transport
VPBB_RS06015	COG2949	membrane
VPBB_RS06020	COG0281	malic enzyme
VPBB_RS06025	COG1643	Atp-dependent helicase
VPBB_RS06030	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
VPBB_RS06045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VPBB_RS06080	COG0277	FAD linked oxidase domain protein
VPBB_RS06080	COG0247	lactate metabolic process
VPBB_RS06095	COG2986	histidine ammonia-lyase
VPBB_RS06100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VPBB_RS06105	COG0010	Belongs to the arginase family
VPBB_RS06110	COG1228	amidohydrolase
VPBB_RS06115	COG2188	Transcriptional regulator
VPBB_RS06130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VPBB_RS06140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VPBB_RS06150	COG0393	Putative heavy-metal-binding
VPBB_RS06180	COG3706	GGDEF domain
VPBB_RS06185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VPBB_RS06190	COG0072	phenylalanine-tRNA ligase activity
VPBB_RS06190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPBB_RS06200	COG0776	regulation of translation
VPBB_RS06210	COG0500	methyltransferase
VPBB_RS06215	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VPBB_RS06220	COG0295	cytidine deaminase activity
VPBB_RS06225	COG1346	cytolysis
VPBB_RS06230	COG1380	Effector of murein hydrolase LrgA
VPBB_RS06235	COG2925	Exonuclease
VPBB_RS06240	COG1823	symporter activity
VPBB_RS06245	COG0702	epimerase
VPBB_RS06250	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VPBB_RS06255	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VPBB_RS06275	COG2988	succinylglutamate desuccinylase activity
VPBB_RS06280	COG4139	cobalamin transport
VPBB_RS06285	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VPBB_RS06305	COG0583	DNA-binding transcription factor activity
VPBB_RS06325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VPBB_RS06330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VPBB_RS06335	COG3475	LICD family
VPBB_RS06340	COG1451	nucleotide metabolic process
VPBB_RS06345	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VPBB_RS06375	COG3938	Belongs to the proline racemase family
VPBB_RS06390	COG2423	ornithine cyclodeaminase activity
VPBB_RS06395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VPBB_RS06400	COG3842	ATPase activity
VPBB_RS06405	COG1176	ABC-type spermidine putrescine transport system, permease component I
VPBB_RS06410	COG1177	transmembrane transport
VPBB_RS06420	COG3291	Pkd domain containing protein
VPBB_RS06435	COG0444	Belongs to the ABC transporter superfamily
VPBB_RS06440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPBB_RS06445	COG0601	transmembrane transport
VPBB_RS06455	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPBB_RS06470	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VPBB_RS06480	COG0625	glutathione transferase activity
VPBB_RS06545	COG0583	DNA-binding transcription factor activity
VPBB_RS06580	COG0471	metal ion transport
VPBB_RS06585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_RS06585	COG4191	Histidine kinase
VPBB_RS06595	COG5001	Diguanylate cyclase
VPBB_RS06595	COG3300	MHYT domain
VPBB_RS06605	COG1280	lysine exporter protein (LysE YggA)
VPBB_RS06610	COG1328	CTP reductase activity
VPBB_RS06615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPBB_RS06625	COG0861	Integral membrane protein TerC family
VPBB_RS06630	COG0739	heme binding
VPBB_RS06655	COG2204	response regulator
VPBB_RS06670	COG3501	Rhs element vgr protein
VPBB_RS06695	COG0515	serine threonine protein kinase
VPBB_RS06730	COG1522	sequence-specific DNA binding
VPBB_RS06800	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VPBB_RS06810	COG0814	amino acid
VPBB_RS06830	COG1132	(ABC) transporter
VPBB_RS06835	COG1132	(ABC) transporter
VPBB_RS06860	COG0443	Heat shock 70 kDa protein
VPBB_RS06865	COG0443	Heat shock 70 kDa protein
VPBB_RS06875	COG3706	GGDEF domain
VPBB_RS06905	COG0243	molybdopterin cofactor binding
VPBB_RS06910	COG0437	4 iron, 4 sulfur cluster binding
VPBB_RS06915	COG3302	dmso reductase anchor subunit
VPBB_RS06930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VPBB_RS06935	COG1643	Atp-dependent helicase
VPBB_RS06950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPBB_RS06960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VPBB_RS06965	COG1215	transferase activity, transferring glycosyl groups
VPBB_RS06970	COG0438	transferase activity, transferring glycosyl groups
VPBB_RS07000	COG0438	transferase activity, transferring glycosyl groups
VPBB_RS07010	COG2204	response regulator
VPBB_RS07040	COG1793	dna ligase
VPBB_RS07050	COG0534	Mate efflux family protein
VPBB_RS07055	COG0307	riboflavin synthase, alpha
VPBB_RS07065	COG3001	Fructosamine kinase
VPBB_RS07070	COG2201	protein-glutamate methylesterase activity
VPBB_RS07075	COG3706	GGDEF domain
VPBB_RS07085	COG0791	NLP P60 protein
VPBB_RS07090	COG0840	transmembrane signaling receptor activity
VPBB_RS07125	COG3148	PFAM DTW domain containing protein
VPBB_RS07130	COG1940	carbohydrate kinase activity
VPBB_RS07140	COG0303	'Molybdopterin
VPBB_RS07145	COG0746	molybdenum cofactor guanylyltransferase activity
VPBB_RS07150	COG3842	ATPase activity
VPBB_RS07165	COG2204	response regulator
VPBB_RS07170	COG4191	Histidine kinase
VPBB_RS07175	COG0488	(ABC) transporter
VPBB_RS07185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VPBB_RS07205	COG3381	protein complex oligomerization
VPBB_RS07215	COG0243	molybdopterin cofactor binding
VPBB_RS07215	COG3383	formate dehydrogenase (NAD+) activity
VPBB_RS07220	COG0437	4 iron, 4 sulfur cluster binding
VPBB_RS07260	COG0004	ammonium transporteR
VPBB_RS07270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VPBB_RS07275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VPBB_RS07285	COG1177	transmembrane transport
VPBB_RS07295	COG3842	ATPase activity
VPBB_RS07315	COG0037	tRNA processing
VPBB_RS07320	COG0589	response to stress
VPBB_RS07325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPBB_RS07340	COG2217	Heavy metal translocating P-type atpase
VPBB_RS07350	COG2010	Cytochrome c
VPBB_RS07365	COG3278	Belongs to the heme-copper respiratory oxidase family
VPBB_RS07380	COG2205	protein histidine kinase activity
VPBB_RS07380	COG0784	Response regulator, receiver
VPBB_RS07395	COG1067	ATP-dependent peptidase activity
VPBB_RS07400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPBB_RS07415	COG0488	(ABC) transporter
VPBB_RS07425	COG0116	Belongs to the methyltransferase superfamily
VPBB_RS07425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VPBB_RS07435	COG0167	dihydroorotate dehydrogenase activity
VPBB_RS07445	COG0308	aminopeptidase N
VPBB_RS07460	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VPBB_RS07465	COG1956	GAF domain-containing protein
VPBB_RS07470	COG1132	(ABC) transporter
VPBB_RS07475	COG2995	paraquat-inducible protein a
VPBB_RS07480	COG3008	intermembrane lipid transfer
VPBB_RS07485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VPBB_RS07485	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VPBB_RS07505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VPBB_RS07510	COG1666	GTP binding
VPBB_RS07520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_RS07525	COG4597	amino acid ABC transporter
VPBB_RS07530	COG0765	amino acid transport
VPBB_RS07535	COG1126	abc transporter atp-binding protein
VPBB_RS07540	COG0670	Belongs to the BI1 family
VPBB_RS07550	COG2920	part of a sulfur-relay system
VPBB_RS07555	COG1254	Belongs to the acylphosphatase family
VPBB_RS07560	COG0840	transmembrane signaling receptor activity
VPBB_RS07565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VPBB_RS07605	COG3706	GGDEF domain
VPBB_RS07610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VPBB_RS07615	COG0602	queuosine metabolic process
VPBB_RS07620	COG0561	phosphatase activity
VPBB_RS07645	COG2828	Protein conserved in bacteria
VPBB_RS07655	COG0372	Belongs to the citrate synthase family
VPBB_RS07660	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VPBB_RS07690	COG0730	response to heat
VPBB_RS07710	COG0457	Tetratricopeptide repeat
VPBB_RS07780	COG4790	Type iii secretion
VPBB_RS07785	COG4794	Type iii secretion
VPBB_RS07790	COG4791	protein targeting
VPBB_RS07795	COG4792	protein secretion
VPBB_RS07805	COG1073	alpha beta
VPBB_RS07810	COG1073	alpha beta
VPBB_RS07840	COG3177	Filamentation induced by cAMP protein fic
VPBB_RS07860	COG4669	(LipO)protein
VPBB_RS07930	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_RS07935	COG3284	Transcriptional regulator
VPBB_RS07955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VPBB_RS07960	COG0363	glucosamine-6-phosphate deaminase activity
VPBB_RS07965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VPBB_RS07970	COG4565	transcriptional regulatory protein
VPBB_RS07975	COG3290	protein histidine kinase activity
VPBB_RS07990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_RS08005	COG1858	cytochrome C peroxidase
VPBB_RS08010	COG0527	aspartate kinase activity
VPBB_RS08015	COG0662	Cupin 2, conserved barrel domain protein
VPBB_RS08020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VPBB_RS08025	COG0456	acetyltransferase
VPBB_RS08030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPBB_RS08050	COG4176	ABC-type proline glycine betaine transport system permease component
VPBB_RS08055	COG2113	Glycine betaine
VPBB_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_RS08085	COG0745	RESPONSE REGULATOR receiver
VPBB_RS08090	COG0642	Histidine kinase
VPBB_RS08095	COG1368	sulfuric ester hydrolase activity
VPBB_RS08120	COG1115	amino acid carrier protein
VPBB_RS08130	COG1280	lysine exporter protein (LysE YggA)
VPBB_RS08135	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VPBB_RS08140	COG1560	Kdo2-lipid A biosynthetic process
VPBB_RS08150	COG0531	amino acid
VPBB_RS08160	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VPBB_RS08165	COG3063	Type IV pilus biogenesis stability protein PilW
VPBB_RS08195	COG0110	maltose O-acetyltransferase activity
VPBB_RS08215	COG2315	Protein conserved in bacteria
VPBB_RS08220	COG1846	Transcriptional regulator
VPBB_RS08235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VPBB_RS08250	COG2771	luxR family
VPBB_RS08250	COG2200	EAL domain
VPBB_RS08255	COG1227	inorganic diphosphatase activity
VPBB_RS08260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VPBB_RS08265	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_RS08270	COG2957	Belongs to the agmatine deiminase family
VPBB_RS08280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VPBB_RS08285	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_RS08290	COG1917	Cupin 2, conserved barrel domain protein
VPBB_RS08290	COG1396	sequence-specific DNA binding
VPBB_RS08295	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VPBB_RS08300	COG0174	glutamine synthetase
VPBB_RS08305	COG1757	Na H antiporter
VPBB_RS08330	COG1280	lysine exporter protein (LysE YggA)
VPBB_RS08355	COG0346	lactoylglutathione lyase activity
VPBB_RS08555	COG2314	TM2 domain
VPBB_RS08570	COG2801	Transposase and inactivated derivatives
VPBB_RS08650	COG2026	Addiction module toxin, RelE StbE family
VPBB_RS08675	COG2026	Addiction module toxin, RelE StbE family
VPBB_RS08745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VPBB_RS08755	COG3768	UPF0283 membrane protein
VPBB_RS08760	COG3106	COG3106 Predicted ATPase
VPBB_RS08775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VPBB_RS08780	COG2205	protein histidine kinase activity
VPBB_RS08780	COG0784	Response regulator, receiver
VPBB_RS08790	COG0494	nUDIX hydrolase
VPBB_RS08795	COG0814	amino acid
VPBB_RS08800	COG1760	l-serine dehydratase
VPBB_RS08805	COG2200	EAL domain
VPBB_RS08815	COG0720	synthase
VPBB_RS08825	COG0017	Asparaginyl-tRNA synthetase
VPBB_RS08835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPBB_RS08850	COG1448	Aminotransferase
VPBB_RS08875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPBB_RS08880	COG1846	Transcriptional regulator
VPBB_RS08905	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VPBB_RS08920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VPBB_RS08925	COG3108	Peptidase M15
VPBB_RS08930	COG2989	Protein conserved in bacteria
VPBB_RS08955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VPBB_RS08965	COG3088	subunit of a heme lyase
VPBB_RS08965	COG4235	cytochrome complex assembly
VPBB_RS08975	COG1138	Cytochrome C-type biogenesis protein
VPBB_RS08980	COG3301	Polysulphide reductase, NrfD
VPBB_RS08985	COG0437	4 iron, 4 sulfur cluster binding
VPBB_RS08995	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VPBB_RS09015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VPBB_RS09020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VPBB_RS09025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VPBB_RS09050	COG0019	diaminopimelate decarboxylase activity
VPBB_RS09090	COG0322	excinuclease ABC activity
VPBB_RS09095	COG2197	response regulator
VPBB_RS09100	COG0417	DNA replication proofreading
VPBB_RS09110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VPBB_RS09115	COG3099	Belongs to the UPF0263 family
VPBB_RS09120	COG1187	pseudouridine synthase activity
VPBB_RS09130	COG0009	L-threonylcarbamoyladenylate synthase
VPBB_RS09135	COG0613	PHP domain protein
VPBB_RS09145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VPBB_RS09150	COG0512	Glutamine amidotransferase of anthranilate synthase
VPBB_RS09155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VPBB_RS09160	COG0134	indole-3-glycerol-phosphate synthase activity
VPBB_RS09160	COG0135	phosphoribosylanthranilate isomerase activity
VPBB_RS09165	COG0133	tryptophan synthase activity
VPBB_RS09170	COG0159	tryptophan synthase activity
VPBB_RS09175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPBB_RS09180	COG0318	PFAM AMP-dependent synthetase and ligase
VPBB_RS09185	COG1301	dicarboxylic acid transport
VPBB_RS09205	COG2917	probably involved in intracellular septation
VPBB_RS09215	COG2350	Protein conserved in bacteria
VPBB_RS09225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VPBB_RS09230	COG0583	DNA-binding transcription factor activity
VPBB_RS09245	COG3706	GGDEF domain
VPBB_RS09245	COG2203	Gaf domain
VPBB_RS09245	COG4251	negative regulation of phosphorylation
VPBB_RS09245	COG5001	Diguanylate cyclase
VPBB_RS09250	COG1032	radical SAM domain protein
VPBB_RS09255	COG0840	transmembrane signaling receptor activity
VPBB_RS09260	COG0745	RESPONSE REGULATOR receiver
VPBB_RS09265	COG5002	protein histidine kinase activity
VPBB_RS09265	COG3850	Histidine kinase
VPBB_RS09315	COG1335	isochorismatase
VPBB_RS09320	COG1136	(ABC) transporter
VPBB_RS09320	COG0577	efflux transmembrane transporter activity
VPBB_RS09330	COG1136	(ABC) transporter
VPBB_RS09330	COG0577	efflux transmembrane transporter activity
VPBB_RS09340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_RS09370	COG3118	belongs to the thioredoxin family
VPBB_RS09375	COG4232	protein-disulfide reductase activity
VPBB_RS09415	COG2863	cytochrome
VPBB_RS09420	COG3258	Cytochrome c
VPBB_RS09425	COG2995	paraquat-inducible protein a
VPBB_RS09430	COG3008	intermembrane lipid transfer
VPBB_RS09430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VPBB_RS09440	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VPBB_RS09465	COG4166	transmembrane transport
VPBB_RS09470	COG0284	orotidine-5'-phosphate decarboxylase activity
VPBB_RS09475	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VPBB_RS09480	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VPBB_RS09490	COG0539	negative regulation of cytoplasmic translation
VPBB_RS09495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VPBB_RS09500	COG0616	signal peptide processing
VPBB_RS09505	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_RS09520	COG0587	DNA-directed DNA polymerase activity
VPBB_RS09525	COG0835	chemotaxis
VPBB_RS09525	COG0784	Response regulator, receiver
VPBB_RS09530	COG1940	carbohydrate kinase activity
VPBB_RS09535	COG0469	pyruvate kinase activity
VPBB_RS09540	COG4667	esterase of the alpha-beta hydrolase superfamily
VPBB_RS09555	COG0733	neurotransmitter:sodium symporter activity
VPBB_RS09565	COG1263	PTS System
VPBB_RS09565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPBB_RS09570	COG0084	hydrolase, TatD family'
VPBB_RS09580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VPBB_RS09585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VPBB_RS09615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VPBB_RS09620	COG0416	fatty acid biosynthetic process
VPBB_RS09630	COG1399	metal-binding, possibly nucleic acid-binding protein
VPBB_RS09635	COG0424	maF-like protein
VPBB_RS09640	COG0564	pseudouridine synthase activity
VPBB_RS09645	COG1530	ribonuclease E activity
VPBB_RS09650	COG0659	secondary active sulfate transmembrane transporter activity
VPBB_RS09655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VPBB_RS09660	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VPBB_RS09670	COG0572	uridine kinase
VPBB_RS09675	COG0489	protein tyrosine kinase activity
VPBB_RS09680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPBB_RS09680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPBB_RS09690	COG2186	Transcriptional regulator
VPBB_RS09695	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPBB_RS09700	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VPBB_RS09705	COG0653	protein targeting
VPBB_RS09710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPBB_RS09720	COG0366	Alpha amylase catalytic
VPBB_RS09725	COG1122	ATPase activity
VPBB_RS09730	COG4120	Belongs to the binding-protein-dependent transport system permease family
VPBB_RS09740	COG3092	negative regulation of chromosome organization
VPBB_RS09745	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VPBB_RS09750	COG0857	belongs to the CobB CobQ family
VPBB_RS09750	COG0280	phosphate acetyltransferase
VPBB_RS09755	COG3174	membrane
VPBB_RS09765	COG0435	Glutathione S-transferase
VPBB_RS09775	COG0444	Belongs to the ABC transporter superfamily
VPBB_RS09780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPBB_RS09785	COG0601	transmembrane transport
VPBB_RS09795	COG0314	molybdopterin synthase activity
VPBB_RS09800	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VPBB_RS09805	COG0315	cyclic pyranopterin monophosphate synthase activity
VPBB_RS09810	COG0521	Mo-molybdopterin cofactor biosynthetic process
VPBB_RS09815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VPBB_RS09820	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VPBB_RS09825	COG2198	Histidine kinase
VPBB_RS09830	COG2204	response regulator
VPBB_RS09835	COG0556	nucleotide-excision repair
VPBB_RS09845	COG4657	Part of a membrane complex involved in electron transport
VPBB_RS09850	COG2878	Part of a membrane complex involved in electron transport
VPBB_RS09855	COG4656	Part of a membrane complex involved in electron transport
VPBB_RS09860	COG4658	electron transport chain
VPBB_RS09865	COG4659	FMN binding
VPBB_RS09870	COG4660	Part of a membrane complex involved in electron transport
VPBB_RS09875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VPBB_RS09880	COG0346	lactoylglutathione lyase activity
VPBB_RS09890	COG2885	chlorophyll binding
VPBB_RS09895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VPBB_RS09900	COG2056	Na+-H+ antiporter family
VPBB_RS09910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VPBB_RS09930	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_RS09930	COG1454	alcohol dehydrogenase
VPBB_RS09935	COG2095	MarC family integral membrane protein
VPBB_RS09940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPBB_RS09945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VPBB_RS09950	COG1757	Na H antiporter
VPBB_RS09965	COG3081	Nucleoid-associated protein
VPBB_RS09970	COG3082	Protein of unknown function (DUF1414)
VPBB_RS09975	COG3083	sulfuric ester hydrolase activity
VPBB_RS09985	COG0123	including yeast histone deacetylase and acetoin utilization protein
VPBB_RS10000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPBB_RS10005	COG0778	Nitroreductase
VPBB_RS10010	COG1902	pentaerythritol trinitrate reductase activity
VPBB_RS10010	COG0446	pyridine nucleotide-disulphide oxidoreductase
VPBB_RS10015	COG0616	signal peptide processing
VPBB_RS10020	COG0252	asparaginase activity
VPBB_RS10025	COG3139	Protein of unknown function (DUF1315)
VPBB_RS10035	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPBB_RS10040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPBB_RS10055	COG2226	methyltransferase
VPBB_RS10070	COG1785	Belongs to the alkaline phosphatase family
VPBB_RS10080	COG0346	lactoylglutathione lyase activity
VPBB_RS10085	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VPBB_RS10090	COG0668	transmembrane transport
VPBB_RS10095	COG2983	Belongs to the UPF0260 family
VPBB_RS10100	COG2261	transglycosylase associated protein
VPBB_RS10115	COG3681	Belongs to the UPF0597 family
VPBB_RS10120	COG0251	oxidation-reduction process
VPBB_RS10125	COG0814	amino acid
VPBB_RS10130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VPBB_RS10135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VPBB_RS10140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VPBB_RS10150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VPBB_RS10155	COG2832	Protein of unknown function (DUF454)
VPBB_RS10165	COG0745	RESPONSE REGULATOR receiver
VPBB_RS10170	COG0583	DNA-binding transcription factor activity
VPBB_RS10175	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VPBB_RS10180	COG1286	toxin biosynthetic process
VPBB_RS10185	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VPBB_RS10190	COG0285	dihydrofolate synthase activity
VPBB_RS10195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VPBB_RS10200	COG0101	tRNA pseudouridine synthase activity
VPBB_RS10210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VPBB_RS10215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPBB_RS10220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VPBB_RS10225	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VPBB_RS10225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VPBB_RS10230	COG0431	NADPH-dependent FMN reductase
VPBB_RS10240	COG3101	peptidyl-lysine hydroxylation
VPBB_RS10245	COG2860	membrane
VPBB_RS10250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VPBB_RS10255	COG2890	protein-(glutamine-N5) methyltransferase activity
VPBB_RS10260	COG2840	Smr protein MutS2
VPBB_RS10265	COG2062	phosphohistidine phosphatase, SixA
VPBB_RS10280	COG1250	3-hydroxyacyl-CoA dehydrogenase
VPBB_RS10280	COG1024	Enoyl-CoA hydratase
VPBB_RS10285	COG0183	Belongs to the thiolase family
VPBB_RS10300	COG2067	long-chain fatty acid transport protein
VPBB_RS10310	COG2853	Lipoprotein
VPBB_RS10325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VPBB_RS10330	COG1138	Cytochrome C-type biogenesis protein
VPBB_RS10335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VPBB_RS10340	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPBB_RS10345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPBB_RS10350	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPBB_RS10355	COG4133	protoheme IX ABC transporter activity
VPBB_RS10365	COG0835	chemotaxis
VPBB_RS10375	COG1192	Involved in chromosome partitioning
VPBB_RS10380	COG2201	protein-glutamate methylesterase activity
VPBB_RS10385	COG0643	Histidine kinase
VPBB_RS10385	COG2198	Histidine kinase
VPBB_RS10385	COG0784	Response regulator, receiver
VPBB_RS10390	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VPBB_RS10430	COG1987	bacterial-type flagellum assembly
VPBB_RS10480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VPBB_RS10490	COG1677	Flagellar hook-basal body complex protein FliE
VPBB_RS10510	COG1516	flagellar protein fliS
VPBB_RS10520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VPBB_RS10525	COG1334	flagellar protein FlaG
VPBB_RS10530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_RS10535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_RS10540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_RS10545	COG2837	iron assimilation
VPBB_RS10570	COG1393	Belongs to the ArsC family
VPBB_RS10575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPBB_RS10590	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VPBB_RS10595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VPBB_RS10600	COG2716	regulation of RNA biosynthetic process
VPBB_RS10605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VPBB_RS10620	COG4783	chaperone-mediated protein folding
VPBB_RS10625	COG1393	Belongs to the ArsC family
VPBB_RS10645	COG2233	PERMEase
VPBB_RS10650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VPBB_RS10655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VPBB_RS10660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VPBB_RS10665	COG0121	glutamine amidotransferase
VPBB_RS10670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VPBB_RS10675	COG1960	acyl-CoA dehydrogenase activity
VPBB_RS10690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VPBB_RS10695	COG0328	RNA-DNA hybrid ribonuclease activity
VPBB_RS10700	COG2226	methyltransferase
VPBB_RS10705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VPBB_RS10710	COG1388	LysM domain
VPBB_RS10710	COG0741	lytic transglycosylase activity
VPBB_RS10720	COG3021	interspecies interaction between organisms
VPBB_RS10725	COG0347	Belongs to the P(II) protein family
VPBB_RS10735	COG0037	tRNA processing
VPBB_RS10740	COG0825	malonyl-CoA metabolic process
VPBB_RS10745	COG0587	DNA-directed DNA polymerase activity
VPBB_RS10750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VPBB_RS10755	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPBB_RS10760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPBB_RS10765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPBB_RS10770	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPBB_RS10775	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VPBB_RS10785	COG0750	zinc metalloprotease
VPBB_RS10790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VPBB_RS10795	COG0575	Belongs to the CDS family
VPBB_RS10800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VPBB_RS10805	COG0233	cytoplasmic translational termination
VPBB_RS10810	COG0528	UMP kinase activity
VPBB_RS10815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VPBB_RS10820	COG0052	Belongs to the universal ribosomal protein uS2 family
VPBB_RS10825	COG0024	Methionine aminopeptidase
VPBB_RS10830	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VPBB_RS10840	COG0564	pseudouridine synthase activity
VPBB_RS10845	COG3098	single-species biofilm formation
VPBB_RS10865	COG1671	Belongs to the UPF0178 family
VPBB_RS10870	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VPBB_RS10875	COG0254	rRNA binding
VPBB_RS10880	COG1720	tRNA m6t6A37 methyltransferase activity
VPBB_RS10885	COG0442	prolyl-tRNA aminoacylation
VPBB_RS10905	COG0733	neurotransmitter:sodium symporter activity
VPBB_RS10920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPBB_RS10925	COG0514	ATP-dependent DNA helicase (RecQ)
VPBB_RS10930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VPBB_RS10935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VPBB_RS10975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VPBB_RS11030	COG1477	protein flavinylation
VPBB_RS11035	COG2871	sodium ion transport
VPBB_RS11040	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPBB_RS11045	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPBB_RS11050	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPBB_RS11055	COG1805	sodium ion transport
VPBB_RS11060	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPBB_RS11070	COG0271	Belongs to the BolA IbaG family
VPBB_RS11075	COG2813	Specifically methylates the guanine in position
VPBB_RS11080	COG3056	Lipoprotein
VPBB_RS11100	COG1595	DNA-templated transcription, initiation
VPBB_RS11115	COG3248	Nucleoside-binding outer membrane protein
VPBB_RS11120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VPBB_RS11125	COG0693	protein deglycase activity
VPBB_RS11130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VPBB_RS11135	COG3706	GGDEF domain
VPBB_RS11140	COG2166	iron-sulfur cluster assembly
VPBB_RS11145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VPBB_RS11150	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VPBB_RS11160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VPBB_RS11160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VPBB_RS11165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VPBB_RS11170	COG1074	ATP-dependent DNA helicase activity
VPBB_RS11180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VPBB_RS11200	COG3141	response to X-ray
VPBB_RS11205	COG2171	N-acyltransferase activity
VPBB_RS11210	COG0584	glycerophosphoryl diester phosphodiesterase
VPBB_RS11215	COG2271	Major facilitator Superfamily
VPBB_RS11225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VPBB_RS11230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VPBB_RS11235	COG1349	DNA-binding transcription factor activity
VPBB_RS11240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VPBB_RS11245	COG0598	Magnesium transport protein CorA
VPBB_RS11265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPBB_RS11270	COG1609	Transcriptional regulator
VPBB_RS11275	COG2176	DNA-directed DNA polymerase activity
VPBB_RS11290	COG2017	converts alpha-aldose to the beta-anomer
VPBB_RS11295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VPBB_RS11305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VPBB_RS11310	COG1609	Transcriptional regulator
VPBB_RS11315	COG3250	beta-galactosidase activity
VPBB_RS11320	COG2731	YhcH YjgK YiaL family protein
VPBB_RS11325	COG0531	amino acid
VPBB_RS11330	COG0583	DNA-binding transcription factor activity
VPBB_RS11390	COG4964	Belongs to the GSP D family
VPBB_RS11415	COG2169	Transcriptional regulator
VPBB_RS11420	COG1022	Amp-dependent synthetase and ligase
VPBB_RS11430	COG0583	DNA-binding transcription factor activity
VPBB_RS11435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPBB_RS11440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VPBB_RS11450	COG0560	Phosphoserine phosphatase
VPBB_RS11460	COG0813	purine-nucleoside phosphorylase activity
VPBB_RS11465	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VPBB_RS11470	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VPBB_RS11475	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VPBB_RS11480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VPBB_RS11485	COG0084	hydrolase, TatD family'
VPBB_RS11495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VPBB_RS11515	COG3153	acetyltransferase
VPBB_RS11520	COG3154	lipid carrier protein
VPBB_RS11530	COG0826	peptidase U32
VPBB_RS11535	COG0826	peptidase U32
VPBB_RS11540	COG0534	Mate efflux family protein
VPBB_RS11555	COG1185	polyribonucleotide nucleotidyltransferase activity
VPBB_RS11560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VPBB_RS11565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VPBB_RS11570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VPBB_RS11575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VPBB_RS11580	COG0195	Participates in both transcription termination and antitermination
VPBB_RS11585	COG0779	Required for maturation of 30S ribosomal subunits
VPBB_RS11600	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VPBB_RS11610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPBB_RS11615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VPBB_RS11620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VPBB_RS11625	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VPBB_RS11630	COG1534	Rna-binding protein
VPBB_RS11635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPBB_RS11640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VPBB_RS11645	COG2027	D-alanyl-D-alanine carboxypeptidase
VPBB_RS11655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VPBB_RS11660	COG0739	heme binding
VPBB_RS11665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPBB_RS11675	COG0316	Belongs to the HesB IscA family
VPBB_RS11680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VPBB_RS11685	COG0628	permease
VPBB_RS11690	COG2813	Specifically methylates the guanine in position
VPBB_RS11695	COG2198	Histidine kinase
VPBB_RS11695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_RS11695	COG0784	Response regulator, receiver
VPBB_RS11695	COG2205	protein histidine kinase activity
VPBB_RS11700	COG0747	negative chemotaxis
VPBB_RS11710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPBB_RS11715	COG0444	Belongs to the ABC transporter superfamily
VPBB_RS11720	COG4608	Belongs to the ABC transporter superfamily
VPBB_RS11730	COG2971	BadF BadG BcrA BcrD
VPBB_RS11745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPBB_RS11750	COG3842	ATPase activity
VPBB_RS11760	COG1840	ABC-type Fe3 transport system, periplasmic component
VPBB_RS11765	COG0004	ammonium transporteR
VPBB_RS11775	COG3112	Uncharacterised protein family (UPF0231)
VPBB_RS11780	COG1049	propionate catabolic process, 2-methylcitrate cycle
VPBB_RS11785	COG1752	Esterase of the alpha-beta hydrolase superfamily
VPBB_RS11790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VPBB_RS11795	COG1643	Atp-dependent helicase
VPBB_RS11800	COG1489	DNA binding
VPBB_RS11810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPBB_RS11820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VPBB_RS11825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VPBB_RS11830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VPBB_RS11835	COG1560	Kdo2-lipid A biosynthetic process
VPBB_RS11840	COG0842	Transport permease protein
VPBB_RS11845	COG1131	(ABC) transporter
VPBB_RS11850	COG0659	secondary active sulfate transmembrane transporter activity
VPBB_RS11855	COG0288	reversible hydration of carbon dioxide
VPBB_RS11870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPBB_RS11875	COG0508	dehydrogenase complex catalyzes the overall conversion of
VPBB_RS11880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VPBB_RS11885	COG2186	Transcriptional regulator
VPBB_RS11895	COG0157	Belongs to the NadC ModD family
VPBB_RS11905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPBB_RS11910	COG1459	type II secretion system
VPBB_RS11920	COG0237	dephospho-CoA kinase activity
VPBB_RS11925	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VPBB_RS11930	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VPBB_RS11935	COG0335	large ribosomal subunit rRNA binding
VPBB_RS11940	COG0336	Belongs to the RNA methyltransferase TrmD family
VPBB_RS11945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VPBB_RS11950	COG0228	four-way junction DNA binding
VPBB_RS11955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VPBB_RS11960	COG4137	Cytochrome C assembly protein
VPBB_RS11965	COG4536	flavin adenine dinucleotide binding
VPBB_RS11970	COG1854	S-ribosylhomocysteine lyase activity
VPBB_RS11980	COG2918	glutathione biosynthetic process
VPBB_RS11985	COG0612	Peptidase, M16
VPBB_RS11990	COG1238	metal cluster binding
VPBB_RS12000	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VPBB_RS12005	COG5016	pyruvate
VPBB_RS12005	COG0511	ligase activity, forming carbon-carbon bonds
VPBB_RS12010	COG3630	sodium ion export across plasma membrane
VPBB_RS12075	COG0527	aspartate kinase activity
VPBB_RS12080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VPBB_RS12085	COG2137	regulation of response to DNA damage stimulus
VPBB_RS12090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VPBB_RS12095	COG1546	Belongs to the CinA family
VPBB_RS12100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VPBB_RS12105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VPBB_RS12115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VPBB_RS12120	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VPBB_RS12125	COG0585	pseudouridine synthase activity
VPBB_RS12130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VPBB_RS12135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VPBB_RS12140	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VPBB_RS12145	COG0148	phosphopyruvate hydratase activity
VPBB_RS12150	COG0504	CTP synthase activity
VPBB_RS12155	COG3956	TIGRFAM MazG family protein
VPBB_RS12160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VPBB_RS12165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VPBB_RS12175	COG0736	holo-[acyl-carrier-protein] synthase activity
VPBB_RS12180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VPBB_RS12185	COG1381	Involved in DNA repair and RecF pathway recombination
VPBB_RS12190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VPBB_RS12195	COG0571	ribonuclease III activity
VPBB_RS12205	COG0481	GTPase activity
VPBB_RS12210	COG3086	response to oxidative stress
VPBB_RS12220	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VPBB_RS12225	COG1595	DNA-templated transcription, initiation
VPBB_RS12230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VPBB_RS12235	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VPBB_RS12240	COG0354	folic acid binding
VPBB_RS12255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPBB_RS12260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPBB_RS12265	COG3079	Belongs to the UPF0149 family
VPBB_RS12270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VPBB_RS12275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VPBB_RS12280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VPBB_RS12285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPBB_RS12295	COG0583	DNA-binding transcription factor activity
VPBB_RS12305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VPBB_RS12310	COG0668	transmembrane transport
VPBB_RS12315	COG0191	fructose-bisphosphate aldolase activity
VPBB_RS12320	COG0126	phosphoglycerate kinase activity
VPBB_RS12325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPBB_RS12330	COG4771	TonB-dependent receptor
VPBB_RS12335	COG0583	DNA-binding transcription factor activity
VPBB_RS12340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VPBB_RS12350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VPBB_RS12360	COG3091	SprT-like family
VPBB_RS12365	COG2356	endonuclease I
VPBB_RS12370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VPBB_RS12375	COG0189	ligase activity
VPBB_RS12380	COG1678	Uncharacterized ACR, COG1678
VPBB_RS12385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VPBB_RS12400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VPBB_RS12405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VPBB_RS12410	COG0762	integral membrane protein
VPBB_RS12415	COG1872	DUF167
VPBB_RS12425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VPBB_RS12430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VPBB_RS12435	COG2066	Belongs to the glutaminase family
VPBB_RS12445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VPBB_RS12455	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VPBB_RS12460	COG0741	lytic transglycosylase activity
VPBB_RS12500	COG0840	transmembrane signaling receptor activity
VPBB_RS12530	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_RS12575	COG3437	response regulator, receiver
VPBB_RS12585	COG3394	polysaccharide catabolic process
VPBB_RS12590	COG1486	melibiose metabolic process
VPBB_RS12595	COG1447	Phosphotransferase system cellobiose-specific component IIA
VPBB_RS12600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VPBB_RS12605	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VPBB_RS12610	COG0726	polysaccharide deacetylase
VPBB_RS12620	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_RS12635	COG0795	lipopolysaccharide-transporting ATPase activity
VPBB_RS12640	COG0795	lipopolysaccharide-transporting ATPase activity
VPBB_RS12645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VPBB_RS12650	COG2927	DNA polymerase III (CHI subunit)
VPBB_RS12655	COG0525	valine-tRNA ligase activity
VPBB_RS12680	COG2235	arginine
VPBB_RS12685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VPBB_RS12690	COG0540	Belongs to the ATCase OTCase family
VPBB_RS12695	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VPBB_RS12700	COG0251	oxidation-reduction process
VPBB_RS12705	COG0204	Acyl-transferase
VPBB_RS12710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VPBB_RS12715	COG5007	Belongs to the BolA IbaG family
VPBB_RS12725	COG2854	intermembrane phospholipid transfer
VPBB_RS12730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VPBB_RS12735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VPBB_RS12740	COG1127	ABC transporter
VPBB_RS12750	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VPBB_RS12750	COG0517	IMP dehydrogenase activity
VPBB_RS12760	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VPBB_RS12765	COG1137	ATPase activity
VPBB_RS12775	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VPBB_RS12780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_RS12785	COG1660	Displays ATPase and GTPase activities
VPBB_RS12790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_RS12795	COG2239	Acts as a magnesium transporter
VPBB_RS12800	COG0312	modulator of DNA gyrase
VPBB_RS12805	COG3028	Belongs to the UPF0307 family
VPBB_RS12810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VPBB_RS12815	COG0564	pseudouridine synthase activity
VPBB_RS12825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VPBB_RS12830	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VPBB_RS12835	COG0312	modulator of DNA gyrase
VPBB_RS12840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VPBB_RS12845	COG3164	Protein of unknown function
VPBB_RS12855	COG0424	maF-like protein
VPBB_RS12860	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VPBB_RS12865	COG1792	Involved in formation and maintenance of cell shape
VPBB_RS12870	COG1077	Cell shape determining protein MreB Mrl
VPBB_RS12905	COG2165	general secretion pathway protein
VPBB_RS12915	COG1459	type II secretion system
VPBB_RS12920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPBB_RS12930	COG3267	Type II secretory pathway component ExeA
VPBB_RS12930	COG3409	Peptidoglycan-binding domain 1 protein
VPBB_RS12955	COG2200	EAL domain
VPBB_RS12955	COG2199	diguanylate cyclase activity
VPBB_RS12960	COG0629	single-stranded DNA binding
VPBB_RS12975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VPBB_RS12985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VPBB_RS12995	COG0527	aspartate kinase activity
VPBB_RS13000	COG0646	methionine synthase
VPBB_RS13000	COG1410	methionine synthase
VPBB_RS13040	COG0175	sulfate reduction
VPBB_RS13045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VPBB_RS13050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VPBB_RS13070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPBB_RS13075	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VPBB_RS13155	COG4695	Portal protein
VPBB_RS13290	COG0735	belongs to the Fur family
VPBB_RS13300	COG0166	Belongs to the GPI family
VPBB_RS13305	COG0432	Pfam Uncharacterised protein family UPF0047
VPBB_RS13315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPBB_RS13330	COG0359	binds to the 23S rRNA
VPBB_RS13340	COG2965	DNA replication, synthesis of RNA primer
VPBB_RS13345	COG0360	Binds together with S18 to 16S ribosomal RNA
VPBB_RS13350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VPBB_RS13355	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VPBB_RS13365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VPBB_RS13370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VPBB_RS13400	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VPBB_RS13410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VPBB_RS13410	COG0678	peroxiredoxin activity
VPBB_RS13420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VPBB_RS13420	COG0165	Argininosuccinate lyase
VPBB_RS13425	COG0137	argininosuccinate synthase activity
VPBB_RS13430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VPBB_RS13435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VPBB_RS13440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPBB_RS13445	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VPBB_RS13455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VPBB_RS13460	COG0460	homoserine dehydrogenase
VPBB_RS13460	COG0527	aspartate kinase activity
VPBB_RS13465	COG0626	cystathionine gamma-synthase activity
VPBB_RS13475	COG0281	malic enzyme
VPBB_RS13485	COG2906	2 iron, 2 sulfur cluster binding
VPBB_RS13490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VPBB_RS13495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPBB_RS13500	COG0049	tRNA binding
VPBB_RS13510	COG2168	tRNA wobble position uridine thiolation
VPBB_RS13515	COG2923	Belongs to the DsrF TusC family
VPBB_RS13520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VPBB_RS13525	COG2964	Protein conserved in bacteria
VPBB_RS13530	COG0545	Peptidyl-prolyl cis-trans isomerase
VPBB_RS13540	COG2900	Belongs to the SlyX family
VPBB_RS13545	COG1446	asparaginase
VPBB_RS13550	COG1047	Peptidyl-prolyl cis-trans
VPBB_RS13565	COG2249	NAD(P)H dehydrogenase (quinone) activity
VPBB_RS13570	COG0488	(ABC) transporter
VPBB_RS13580	COG0429	hydrolase of the alpha beta-hydrolase fold
VPBB_RS13585	COG3089	Belongs to the UPF0270 family
VPBB_RS13590	COG3954	Phosphoribulokinase
VPBB_RS13595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPBB_RS13605	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_RS13615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VPBB_RS13620	COG0512	Glutamine amidotransferase of anthranilate synthase
VPBB_RS13635	COG0180	Tryptophanyl-tRNA synthetase
VPBB_RS13640	COG0546	phosphoglycolate phosphatase activity
VPBB_RS13645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPBB_RS13650	COG0557	exoribonuclease II activity
VPBB_RS13655	COG1959	2 iron, 2 sulfur cluster binding
VPBB_RS13660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VPBB_RS13660	COG1017	nitric oxide dioxygenase activity
VPBB_RS13665	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VPBB_RS13670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VPBB_RS13675	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VPBB_RS13680	COG0330	HflC and HflK could
VPBB_RS13685	COG0330	HflC and HflK could
VPBB_RS13690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VPBB_RS13700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VPBB_RS13705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VPBB_RS13715	COG0802	atpase or kinase
VPBB_RS13720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VPBB_RS13790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VPBB_RS13795	COG1162	GTPase activity
VPBB_RS13800	COG0688	phosphatidylethanolamine metabolic process
VPBB_RS13805	COG0471	metal ion transport
VPBB_RS13810	COG0840	transmembrane signaling receptor activity
VPBB_RS13820	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VPBB_RS13830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPBB_RS13835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VPBB_RS13840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VPBB_RS13845	COG1045	serine acetyltransferase
VPBB_RS13850	COG4942	peptidase
VPBB_RS13870	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VPBB_RS13875	COG1053	succinate dehydrogenase
VPBB_RS13880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VPBB_RS13885	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VPBB_RS13890	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VPBB_RS13900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VPBB_RS13905	COG1509	lysine 2,3-aminomutase activity
VPBB_RS13910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPBB_RS13930	COG0459	protein refolding
VPBB_RS13940	COG0534	Mate efflux family protein
VPBB_RS13945	COG0205	6-phosphofructokinase activity
VPBB_RS13960	COG0745	RESPONSE REGULATOR receiver
VPBB_RS13965	COG2205	protein histidine kinase activity
VPBB_RS13975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VPBB_RS13985	COG1027	Aspartate ammonia-lyase
VPBB_RS13990	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VPBB_RS13995	COG4232	protein-disulfide reductase activity
VPBB_RS14005	COG3263	regulation of cellular component size
VPBB_RS14015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VPBB_RS14035	COG0784	Response regulator, receiver
VPBB_RS14035	COG2205	protein histidine kinase activity
VPBB_RS14040	COG2814	Major facilitator Superfamily
VPBB_RS14055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VPBB_RS14060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VPBB_RS14065	COG0511	ligase activity, forming carbon-carbon bonds
VPBB_RS14070	COG0439	Biotin carboxylase
VPBB_RS14075	COG2264	protein methyltransferase activity
VPBB_RS14080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPBB_RS14085	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VPBB_RS14095	COG0488	(ABC) transporter
VPBB_RS14100	COG3706	GGDEF domain
VPBB_RS14175	COG1982	Orn Lys Arg decarboxylase major
VPBB_RS14180	COG0531	amino acid
VPBB_RS14185	COG3710	Transcriptional regulator
VPBB_RS14190	COG0789	Transcriptional regulator
VPBB_RS14195	COG0138	bifunctional purine biosynthesis protein purh
VPBB_RS14200	COG0151	Belongs to the GarS family
VPBB_RS14215	COG1253	flavin adenine dinucleotide binding
VPBB_RS14225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPBB_RS14230	COG1573	uracil-dna glycosylase
VPBB_RS14235	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VPBB_RS14250	COG2816	NAD+ diphosphatase activity
VPBB_RS14255	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VPBB_RS14260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VPBB_RS14265	COG0085	RNA polymerase activity
VPBB_RS14270	COG0222	ribosome binding
VPBB_RS14275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VPBB_RS14280	COG0081	regulation of translation
VPBB_RS14285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VPBB_RS14290	COG0250	Participates in transcription elongation, termination and antitermination
VPBB_RS14295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VPBB_RS14300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VPBB_RS14335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VPBB_RS14345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VPBB_RS14390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VPBB_RS14400	COG4206	TonB-dependent receptor
VPBB_RS14420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPBB_RS14425	COG0534	Mate efflux family protein
VPBB_RS14430	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VPBB_RS14435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VPBB_RS14440	COG2937	Belongs to the GPAT DAPAT family
VPBB_RS14445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VPBB_RS14450	COG3161	chorismate lyase activity
VPBB_RS14455	COG1580	Controls the rotational direction of flagella during chemotaxis
VPBB_RS14460	COG0705	Rhomboid family
VPBB_RS14465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPBB_RS14475	COG2177	Part of the ABC transporter FtsEX involved in
VPBB_RS14480	COG2884	Cell division ATP-binding protein ftsE
VPBB_RS14485	COG0552	protein localization to endoplasmic reticulum
VPBB_RS14490	COG0742	ribosomal rna small subunit methyltransferase
VPBB_RS14500	COG2095	MarC family integral membrane protein
VPBB_RS14555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPBB_RS14560	COG0640	Transcriptional regulator
VPBB_RS14565	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VPBB_RS14570	COG1280	lysine exporter protein (LysE YggA)
VPBB_RS14575	COG2267	carboxylic ester hydrolase activity
VPBB_RS14580	COG0561	phosphatase activity
VPBB_RS14595	COG3148	PFAM DTW domain containing protein
VPBB_RS14600	COG2200	EAL domain
VPBB_RS14600	COG3287	FIST C domain
VPBB_RS14600	COG2199	diguanylate cyclase activity
VPBB_RS14605	COG1011	Hydrolase
VPBB_RS14610	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VPBB_RS14620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VPBB_RS14625	COG0019	diaminopimelate decarboxylase activity
VPBB_RS14635	COG1965	Belongs to the frataxin family
VPBB_RS14640	COG3072	Adenylate cyclase
VPBB_RS14645	COG0181	hydroxymethylbilane synthase activity
VPBB_RS14650	COG1587	Uroporphyrinogen-III synthase
VPBB_RS14655	COG2959	enzyme of heme biosynthesis
VPBB_RS14660	COG3071	HemY protein
VPBB_RS14700	COG0633	Ferredoxin
VPBB_RS14705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VPBB_RS14720	COG3118	belongs to the thioredoxin family
VPBB_RS14725	COG0513	Belongs to the DEAD box helicase family
VPBB_RS14730	COG0248	Ppx GppA phosphatase
VPBB_RS14735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VPBB_RS14745	COG0514	ATP-dependent DNA helicase (RecQ)
VPBB_RS14750	COG2962	Rard protein
VPBB_RS14760	COG1280	lysine exporter protein (LysE YggA)
VPBB_RS14765	COG0405	Gamma-glutamyltransferase
VPBB_RS14770	COG0210	DNA helicase
VPBB_RS14780	COG3220	belongs to the UPF0276 family
VPBB_RS14810	COG0006	proline dipeptidase activity
VPBB_RS14810	COG0006	proline dipeptidase activity
VPBB_RS14820	COG2022	thiamine diphosphate biosynthetic process
VPBB_RS14825	COG2104	thiamine diphosphate biosynthetic process
VPBB_RS14830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VPBB_RS14835	COG0352	thiamine-phosphate diphosphorylase activity
VPBB_RS14840	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VPBB_RS14845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VPBB_RS14895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VPBB_RS14905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VPBB_RS14910	COG0408	coproporphyrinogen oxidase activity
VPBB_RS14915	COG0009	L-threonylcarbamoyladenylate synthase
VPBB_RS14920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VPBB_RS14925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VPBB_RS14930	COG0551	DNA topoisomerase type I activity
VPBB_RS14935	COG2922	Belongs to the Smg family
VPBB_RS14940	COG0758	DNA mediated transformation
VPBB_RS14950	COG0242	peptide deformylase activity
VPBB_RS14955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VPBB_RS14960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VPBB_RS14960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VPBB_RS14965	COG0569	domain protein
VPBB_RS14970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPBB_RS14980	COG1272	protein, Hemolysin III
VPBB_RS14985	COG4326	sporulation control protein
VPBB_RS14990	COG3084	Protein conserved in bacteria
VPBB_RS15000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VPBB_RS15005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPBB_RS15010	COG0204	Acyl-transferase
VPBB_RS15020	COG0606	chelatase, subunit chli
VPBB_RS15065	COG0154	amidase activity
VPBB_RS15100	COG0606	chelatase, subunit chli
VPBB_RS15110	COG3978	acetolactate synthase activity
VPBB_RS15115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VPBB_RS15120	COG0129	dihydroxy-acid dehydratase activity
VPBB_RS15130	COG0583	DNA-binding transcription factor activity
VPBB_RS15135	COG2814	Major facilitator Superfamily
VPBB_RS15140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_RS15145	COG0765	amino acid transport
VPBB_RS15150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VPBB_RS15155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VPBB_RS15160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VPBB_RS15165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VPBB_RS15170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VPBB_RS15175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VPBB_RS15190	COG0356	it plays a direct role in the translocation of protons across the membrane
VPBB_RS15195	COG3312	ion transport
VPBB_RS15200	COG1475	DNA binding
VPBB_RS15205	COG1192	Involved in chromosome partitioning
VPBB_RS15210	COG0357	Ribosomal RNA small subunit methyltransferase G
VPBB_RS15215	COG0445	tRNA wobble uridine modification
VPBB_RS15755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VPBB_RS15895	COG1295	ribonuclease BN
VPBB_RS15900	COG1295	ribonuclease BN
VPBB_RS15945	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VPBB_RS15980	COG4795	General secretion pathway protein
VPBB_RS15990	COG3156	type II secretion system protein K
VPBB_RS16075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VPBB_RS16140	COG0747	negative chemotaxis
VPBB_RS16270	COG0463	Glycosyl transferase, family 2
VPBB_RS16345	COG0859	PFAM glycosyl transferase family 9
VPBB_RS16435	COG0438	transferase activity, transferring glycosyl groups
VPBB_RS16605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VPBB_RS16685	COG0513	Belongs to the DEAD box helicase family
VPBB_RS16725	COG3273	potassium ion transport
VPBB_RS16725	COG0471	metal ion transport
VPBB_RS16730	COG3273	potassium ion transport
VPBB_RS16730	COG0471	metal ion transport
VPBB_RS16820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VPBB_RS17190	COG3267	Type II secretory pathway component ExeA
VPBB_RS17190	COG3409	Peptidoglycan-binding domain 1 protein
VPBB_RS17220	COG1392	Phosphate transport regulator
VPBB_RS17260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VPBB_RS17360	COG0768	penicillin binding
VPBB_RS17460	COG0493	'glutamate synthase
VPBB_RS17605	COG3022	response to hydroperoxide
VPBB_RS17685	COG3066	DNA modification
VPBB_RS17705	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VPBB_RS17780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VPBB_RS17955	COG0826	peptidase U32
VPBB_RS17985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VPBB_RS18160	COG1160	GTP binding
VPBB_RS18230	COG1115	amino acid carrier protein
VPBB_RS18300	COG0497	DNA recombination
VPBB_RS18485	COG0583	DNA-binding transcription factor activity
VPBB_RS18560	COG0366	Alpha amylase catalytic
VPBB_RS18750	COG1187	pseudouridine synthase activity
VPBB_RS18790	COG2608	mercury ion transmembrane transporter activity
VPBB_RS18790	COG2217	Heavy metal translocating P-type atpase
VPBB_RS18910	COG1706	bacterial-type flagellum-dependent cell motility
VPBB_RS19155	COG0567	Dehydrogenase, E1 component
VPBB_RS19185	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VPBB_RS19500	COG4191	Histidine kinase
VPBB_RS19770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VPBB_RS19960	COG1187	pseudouridine synthase activity
VPBB_RS19995	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VPBB_RS20015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPBB_RS20235	COG5002	protein histidine kinase activity
VPBB_RS20235	COG0784	Response regulator, receiver
VPBB_RS20240	COG0784	Response regulator, receiver
VPBB_RS20240	COG2205	protein histidine kinase activity
VPBB_RS20870	COG0702	epimerase
VPBB_RS21200	COG2986	histidine ammonia-lyase
VPBB_RS22050	COG3302	dmso reductase anchor subunit
VPBB_RS22350	COG0243	molybdopterin cofactor binding
VPBB_RS22440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VPBB_RS23030	COG1450	Type ii and iii secretion system protein