locus-tag	class	description
vpachn25_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
vpachn25_RS00010	COG0592	DNA-directed DNA polymerase activity
vpachn25_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
vpachn25_RS00020	COG0187	DNA topoisomerase II activity
vpachn25_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
vpachn25_RS00040	COG3977	Valine--pyruvate aminotransferase
vpachn25_RS00045	COG0366	Alpha amylase catalytic
vpachn25_RS00050	COG0751	glycine-tRNA ligase activity
vpachn25_RS00055	COG0752	glycyl-tRNA synthetase alpha subunit
vpachn25_RS00060	COG2119	membrane
vpachn25_RS00070	COG0425	Belongs to the sulfur carrier protein TusA family
vpachn25_RS00085	COG0604	alcohol dehydrogenase
vpachn25_RS00090	COG0183	Belongs to the thiolase family
vpachn25_RS00095	COG1250	3-hydroxyacyl-CoA dehydrogenase
vpachn25_RS00095	COG1024	Enoyl-CoA hydratase
vpachn25_RS00100	COG1739	Uncharacterized protein family UPF0029
vpachn25_RS00105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
vpachn25_RS00145	COG0583	DNA-binding transcription factor activity
vpachn25_RS00150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
vpachn25_RS00155	COG2960	long-chain fatty acid transporting porin activity
vpachn25_RS00160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vpachn25_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vpachn25_RS00220	COG4172	Belongs to the ABC transporter superfamily
vpachn25_RS00225	COG0747	negative chemotaxis
vpachn25_RS00230	COG0601	transmembrane transport
vpachn25_RS00235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vpachn25_RS00270	COG1609	Transcriptional regulator
vpachn25_RS00275	COG0583	DNA-binding transcription factor activity
vpachn25_RS00290	COG0129	dihydroxy-acid dehydratase activity
vpachn25_RS00295	COG3265	gluconokinase activity
vpachn25_RS00300	COG2610	gluconate transmembrane transporter activity
vpachn25_RS00305	COG0800	Aldolase
vpachn25_RS00310	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
vpachn25_RS00315	COG0583	DNA-binding transcription factor activity
vpachn25_RS00320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
vpachn25_RS00325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
vpachn25_RS00330	COG0339	signal peptide processing
vpachn25_RS00335	COG1522	sequence-specific DNA binding
vpachn25_RS00340	COG5002	protein histidine kinase activity
vpachn25_RS00340	COG5001	Diguanylate cyclase
vpachn25_RS00345	COG0742	ribosomal rna small subunit methyltransferase
vpachn25_RS00360	COG0589	response to stress
vpachn25_RS00365	COG1528	Iron-storage protein
vpachn25_RS00375	COG2081	HI0933 family
vpachn25_RS00385	COG2823	Periplasmic or secreted lipoprotein
vpachn25_RS00405	COG1597	lipid kinase activity
vpachn25_RS00435	COG0628	permease
vpachn25_RS00450	COG1322	Protein conserved in bacteria
vpachn25_RS00455	COG2226	methyltransferase
vpachn25_RS00460	COG3165	ubiquinone biosynthetic process from chorismate
vpachn25_RS00465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
vpachn25_RS00470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
vpachn25_RS00475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
vpachn25_RS00480	COG0805	protein transport
vpachn25_RS00485	COG0084	hydrolase, TatD family'
vpachn25_RS00500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vpachn25_RS00500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vpachn25_RS00505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
vpachn25_RS00540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
vpachn25_RS00550	COG2204	response regulator
vpachn25_RS00555	COG3852	Histidine kinase
vpachn25_RS00565	COG0174	glutamine synthetase
vpachn25_RS00570	COG1217	gtp-binding protein TYPA
vpachn25_RS00585	COG1295	ribonuclease BN
vpachn25_RS00590	COG1490	D-aminoacyl-tRNA deacylase activity
vpachn25_RS00595	COG0456	acetyltransferase
vpachn25_RS00605	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
vpachn25_RS00610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
vpachn25_RS00615	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
vpachn25_RS00620	COG3031	protein transport across the cell outer membrane
vpachn25_RS00630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
vpachn25_RS00635	COG1459	type II secretion system
vpachn25_RS00640	COG2165	general secretion pathway protein
vpachn25_RS00645	COG2165	general secretion pathway protein
vpachn25_RS00650	COG2165	general secretion pathway protein
vpachn25_RS00655	COG4795	General secretion pathway protein
vpachn25_RS00660	COG3156	type II secretion system protein K
vpachn25_RS00665	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
vpachn25_RS00670	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
vpachn25_RS00680	COG1218	3'(2'),5'-bisphosphate nucleotidase
vpachn25_RS00685	COG0494	nUDIX hydrolase
vpachn25_RS00690	COG0316	Belongs to the HesB IscA family
vpachn25_RS00690	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
vpachn25_RS00695	COG1040	competence protein
vpachn25_RS00700	COG0596	Alpha beta hydrolase
vpachn25_RS00710	COG2183	response to ionizing radiation
vpachn25_RS00720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
vpachn25_RS00750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
vpachn25_RS00755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
vpachn25_RS00760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
vpachn25_RS00765	COG1758	RNA polymerase activity
vpachn25_RS00770	COG0194	GDP metabolic process
vpachn25_RS00785	COG0848	biopolymer transport protein
vpachn25_RS00790	COG0811	peptide transport
vpachn25_RS00810	COG4174	ABC transporter (Permease)
vpachn25_RS00815	COG4239	(ABC) transporter, permease
vpachn25_RS00820	COG0747	negative chemotaxis
vpachn25_RS00825	COG0444	Belongs to the ABC transporter superfamily
vpachn25_RS00830	COG4608	Belongs to the ABC transporter superfamily
vpachn25_RS00840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
vpachn25_RS00975	COG1561	YicC-like family, N-terminal region
vpachn25_RS00980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
vpachn25_RS00985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
vpachn25_RS00990	COG1560	Kdo2-lipid A biosynthetic process
vpachn25_RS00995	COG1309	transcriptional regulator
vpachn25_RS01000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
vpachn25_RS01005	COG0840	transmembrane signaling receptor activity
vpachn25_RS01010	COG2003	Belongs to the UPF0758 family
vpachn25_RS01015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
vpachn25_RS01030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
vpachn25_RS01055	COG0463	Glycosyl transferase, family 2
vpachn25_RS01060	COG0859	PFAM glycosyl transferase family 9
vpachn25_RS01065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
vpachn25_RS01070	COG3642	lipopolysaccharide core region biosynthetic process
vpachn25_RS01090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
vpachn25_RS01105	COG1519	Transferase
vpachn25_RS01110	COG0859	PFAM glycosyl transferase family 9
vpachn25_RS01115	COG1560	Kdo2-lipid A biosynthetic process
vpachn25_RS01125	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vpachn25_RS01160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
vpachn25_RS01165	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
vpachn25_RS01175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
vpachn25_RS01180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
vpachn25_RS01185	COG2089	acid synthase
vpachn25_RS01195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
vpachn25_RS01200	COG1083	cytidylyl-transferase
vpachn25_RS01245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
vpachn25_RS01250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
vpachn25_RS01255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
vpachn25_RS01260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
vpachn25_RS01295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
vpachn25_RS01305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
vpachn25_RS01325	COG0149	triose-phosphate isomerase activity
vpachn25_RS01350	COG1494	fructose-1,6-bisphosphatase
vpachn25_RS01355	COG3074	FtsZ-dependent cytokinesis
vpachn25_RS01360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
vpachn25_RS01365	COG1575	Belongs to the MenA family. Type 1 subfamily
vpachn25_RS01370	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
vpachn25_RS01375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
vpachn25_RS01385	COG1609	Transcriptional regulator
vpachn25_RS01390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
vpachn25_RS01395	COG0254	rRNA binding
vpachn25_RS01405	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
vpachn25_RS01410	COG0088	Forms part of the polypeptide exit tunnel
vpachn25_RS01420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
vpachn25_RS01425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
vpachn25_RS01430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
vpachn25_RS01435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
vpachn25_RS01445	COG0255	Belongs to the universal ribosomal protein uL29 family
vpachn25_RS01450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
vpachn25_RS01455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
vpachn25_RS01460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
vpachn25_RS01465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
vpachn25_RS01470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
vpachn25_RS01475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
vpachn25_RS01480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
vpachn25_RS01495	COG1841	ribosomal large subunit assembly
vpachn25_RS01500	COG0200	Binds to the 23S rRNA
vpachn25_RS01505	COG0201	protein transport
vpachn25_RS01510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
vpachn25_RS01515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
vpachn25_RS01520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
vpachn25_RS01530	COG0202	RNA polymerase activity
vpachn25_RS01535	COG0203	ribosomal protein L17
vpachn25_RS01545	COG0545	Peptidyl-prolyl cis-trans isomerase
vpachn25_RS01555	COG2153	protein acetylation
vpachn25_RS01560	COG0513	Belongs to the DEAD box helicase family
vpachn25_RS01570	COG0737	Belongs to the 5'-nucleotidase family
vpachn25_RS01575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
vpachn25_RS01575	COG1648	precorrin-2 dehydrogenase activity
vpachn25_RS01580	COG0175	sulfate reduction
vpachn25_RS01585	COG2895	sulfate adenylyltransferase (ATP) activity
vpachn25_RS01590	COG3273	potassium ion transport
vpachn25_RS01590	COG0471	metal ion transport
vpachn25_RS01595	COG0529	Catalyzes the synthesis of activated sulfate
vpachn25_RS01615	COG4181	ATPase activity
vpachn25_RS01630	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
vpachn25_RS01640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vpachn25_RS01645	COG0729	surface antigen
vpachn25_RS01655	COG2105	PFAM AIG2 family protein
vpachn25_RS01665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
vpachn25_RS01670	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
vpachn25_RS01675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
vpachn25_RS01680	COG0163	prenyltransferase activity
vpachn25_RS01685	COG4143	(ABC) transporter
vpachn25_RS01690	COG1178	ABC-type Fe3 transport system permease component
vpachn25_RS01695	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
vpachn25_RS01710	COG2358	TRAP transporter, solute receptor (TAXI family
vpachn25_RS01720	COG0039	L-malate dehydrogenase activity
vpachn25_RS01730	COG0142	geranyltranstransferase activity
vpachn25_RS01735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
vpachn25_RS01745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
vpachn25_RS01750	COG2966	Psort location CytoplasmicMembrane, score
vpachn25_RS01765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
vpachn25_RS01770	COG2967	ApaG domain
vpachn25_RS01775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
vpachn25_RS01780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
vpachn25_RS01785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
vpachn25_RS01790	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
vpachn25_RS01795	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
vpachn25_RS01805	COG0066	3-isopropylmalate dehydratase activity
vpachn25_RS01810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
vpachn25_RS01815	COG0473	3-isopropylmalate dehydrogenase activity
vpachn25_RS01820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
vpachn25_RS01840	COG0583	DNA-binding transcription factor activity
vpachn25_RS01845	COG1022	Amp-dependent synthetase and ligase
vpachn25_RS01850	COG0028	Belongs to the TPP enzyme family
vpachn25_RS01855	COG0440	acetolactate synthase activity
vpachn25_RS01870	COG0469	pyruvate kinase activity
vpachn25_RS01875	COG1349	DNA-binding transcription factor activity
vpachn25_RS01880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
vpachn25_RS01895	COG5002	protein histidine kinase activity
vpachn25_RS01905	COG2376	Dihydroxyacetone kinase
vpachn25_RS01910	COG1461	Dihydroxyacetone kinase
vpachn25_RS01925	COG3722	fumarate hydratase activity
vpachn25_RS01930	COG0246	Mannitol dehydrogenase
vpachn25_RS01935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
vpachn25_RS01935	COG2213	PTS system mannitol-specific
vpachn25_RS01965	COG1464	Belongs to the NlpA lipoprotein family
vpachn25_RS01980	COG0358	DNA primase activity
vpachn25_RS01985	COG1610	YqeY-like protein
vpachn25_RS01990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
vpachn25_RS01995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
vpachn25_RS02000	COG0596	Alpha beta hydrolase
vpachn25_RS02005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
vpachn25_RS02010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
vpachn25_RS02015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
vpachn25_RS02020	COG1968	undecaprenyl-diphosphatase activity
vpachn25_RS02025	COG0617	tRNA 3'-terminal CCA addition
vpachn25_RS02030	COG3267	Type II secretory pathway component ExeA
vpachn25_RS02030	COG3409	Peptidoglycan-binding domain 1 protein
vpachn25_RS02040	COG4991	sh3 domain protein
vpachn25_RS02045	COG0306	phosphate transporter
vpachn25_RS02050	COG1392	Phosphate transport regulator
vpachn25_RS02055	COG3025	triphosphatase activity
vpachn25_RS02070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
vpachn25_RS02075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
vpachn25_RS02075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
vpachn25_RS02080	COG1538	Outer membrane efflux protein
vpachn25_RS02085	COG0494	nUDIX hydrolase
vpachn25_RS02090	COG3151	Protein conserved in bacteria
vpachn25_RS02100	COG3150	esterase
vpachn25_RS02115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
vpachn25_RS02125	COG3105	Protein conserved in bacteria
vpachn25_RS02130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
vpachn25_RS02135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
vpachn25_RS02140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
vpachn25_RS02145	COG0723	plastoquinol--plastocyanin reductase activity
vpachn25_RS02150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
vpachn25_RS02155	COG2857	Cytochrome c1
vpachn25_RS02160	COG0625	glutathione transferase activity
vpachn25_RS02165	COG2969	positive regulation of protein catabolic process
vpachn25_RS02170	COG2823	Periplasmic or secreted lipoprotein
vpachn25_RS02175	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
vpachn25_RS02180	COG0792	nuclease activity
vpachn25_RS02190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
vpachn25_RS02200	COG0275	rRNA processing
vpachn25_RS02205	COG3116	cell division
vpachn25_RS02210	COG0768	penicillin binding
vpachn25_RS02215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
vpachn25_RS02220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
vpachn25_RS02225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
vpachn25_RS02230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
vpachn25_RS02235	COG0772	Belongs to the SEDS family
vpachn25_RS02240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
vpachn25_RS02245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
vpachn25_RS02250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
vpachn25_RS02255	COG0849	cell division
vpachn25_RS02260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
vpachn25_RS02265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
vpachn25_RS02275	COG0653	protein targeting
vpachn25_RS02280	COG0494	nUDIX hydrolase
vpachn25_RS02285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
vpachn25_RS02290	COG0505	Belongs to the CarA family
vpachn25_RS02295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
vpachn25_RS02310	COG0730	response to heat
vpachn25_RS02315	COG0583	DNA-binding transcription factor activity
vpachn25_RS02320	COG2860	membrane
vpachn25_RS02325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
vpachn25_RS02335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
vpachn25_RS02345	COG0493	'glutamate synthase
vpachn25_RS02350	COG0067	glutamate synthase
vpachn25_RS02350	COG0069	glutamate synthase activity
vpachn25_RS02350	COG0070	glutamate synthase
vpachn25_RS02360	COG0069	glutamate synthase activity
vpachn25_RS02360	COG0067	glutamate synthase
vpachn25_RS02360	COG0070	glutamate synthase
vpachn25_RS02365	COG1242	4 iron, 4 sulfur cluster binding
vpachn25_RS02370	COG2203	Gaf domain
vpachn25_RS02370	COG4251	negative regulation of phosphorylation
vpachn25_RS02370	COG5001	Diguanylate cyclase
vpachn25_RS02370	COG3706	GGDEF domain
vpachn25_RS02375	COG2198	Histidine kinase
vpachn25_RS02375	COG5002	protein histidine kinase activity
vpachn25_RS02375	COG0784	Response regulator, receiver
vpachn25_RS02385	COG0745	RESPONSE REGULATOR receiver
vpachn25_RS02395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
vpachn25_RS02410	COG0083	homoserine kinase activity
vpachn25_RS02415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
vpachn25_RS02420	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
vpachn25_RS02425	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
vpachn25_RS02430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
vpachn25_RS02445	COG1115	amino acid carrier protein
vpachn25_RS02450	COG3022	response to hydroperoxide
vpachn25_RS02455	COG0513	Belongs to the DEAD box helicase family
vpachn25_RS02460	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
vpachn25_RS02470	COG0716	FMN binding
vpachn25_RS02475	COG4974	Belongs to the 'phage' integrase family
vpachn25_RS02480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
vpachn25_RS02485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
vpachn25_RS02490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
vpachn25_RS02495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
vpachn25_RS02510	COG0667	Aldo Keto reductase
vpachn25_RS02520	COG3066	DNA modification
vpachn25_RS02525	COG0494	nUDIX hydrolase
vpachn25_RS02535	COG0730	response to heat
vpachn25_RS02540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
vpachn25_RS02545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
vpachn25_RS02555	COG1283	sodium-dependent phosphate transmembrane transporter activity
vpachn25_RS02560	COG0583	DNA-binding transcription factor activity
vpachn25_RS02565	COG0640	Transcriptional regulator
vpachn25_RS02570	COG0268	Binds directly to 16S ribosomal RNA
vpachn25_RS02575	COG0728	peptidoglycan biosynthetic process
vpachn25_RS02580	COG0196	riboflavin kinase activity
vpachn25_RS02585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
vpachn25_RS02590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
vpachn25_RS02595	COG1047	Peptidyl-prolyl cis-trans
vpachn25_RS02600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
vpachn25_RS02605	COG3279	Response regulator of the LytR AlgR family
vpachn25_RS02610	COG3275	phosphorelay sensor kinase activity
vpachn25_RS02615	COG1966	Carbon starvation protein
vpachn25_RS02630	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
vpachn25_RS02635	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
vpachn25_RS02640	COG1472	Belongs to the glycosyl hydrolase 3 family
vpachn25_RS02645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
vpachn25_RS02650	COG1605	Chorismate mutase
vpachn25_RS02650	COG0287	Prephenate dehydrogenase
vpachn25_RS02655	COG0739	heme binding
vpachn25_RS02670	COG0488	(ABC) transporter
vpachn25_RS02680	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
vpachn25_RS02685	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
vpachn25_RS02690	COG0077	Prephenate dehydratase
vpachn25_RS02690	COG1605	Chorismate mutase
vpachn25_RS02695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
vpachn25_RS02700	COG0741	lytic transglycosylase activity
vpachn25_RS02705	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vpachn25_RS02710	COG0564	pseudouridine synthase activity
vpachn25_RS02720	COG0542	response to heat
vpachn25_RS02775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
vpachn25_RS02780	COG0826	peptidase U32
vpachn25_RS02785	COG2974	May be involved in recombination
vpachn25_RS02790	COG0745	RESPONSE REGULATOR receiver
vpachn25_RS02795	COG5002	protein histidine kinase activity
vpachn25_RS02805	COG0248	Ppx GppA phosphatase
vpachn25_RS02810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
vpachn25_RS02820	COG0581	inorganic phosphate transmembrane transporter activity
vpachn25_RS02825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
vpachn25_RS02830	COG0704	Plays a role in the regulation of phosphate uptake
vpachn25_RS02840	COG3142	Participates in the control of copper homeostasis
vpachn25_RS02845	COG0450	alkyl hydroperoxide reductase
vpachn25_RS02850	COG0583	DNA-binding transcription factor activity
vpachn25_RS02855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
vpachn25_RS02865	COG0517	IMP dehydrogenase activity
vpachn25_RS02875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
vpachn25_RS02880	COG0343	queuine tRNA-ribosyltransferase activity
vpachn25_RS02885	COG1862	Preprotein translocase
vpachn25_RS02890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
vpachn25_RS02895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
vpachn25_RS02900	COG0483	inositol monophosphate 1-phosphatase activity
vpachn25_RS02915	COG1104	cysteine desulfurase activity
vpachn25_RS02920	COG0822	iron-sulfur transferase activity
vpachn25_RS02930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
vpachn25_RS02935	COG0443	Heat shock 70 kDa protein
vpachn25_RS02940	COG0633	Ferredoxin
vpachn25_RS02945	COG2975	iron-sulfur cluster assembly
vpachn25_RS02950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
vpachn25_RS02955	COG0105	UTP biosynthetic process
vpachn25_RS02960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
vpachn25_RS02970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
vpachn25_RS02975	COG0124	histidyl-tRNA synthetase
vpachn25_RS02980	COG2976	Protein conserved in bacteria
vpachn25_RS02985	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vpachn25_RS02990	COG1160	GTP binding
vpachn25_RS03005	COG1570	exodeoxyribonuclease VII activity
vpachn25_RS03010	COG0516	GMP reductase activity
vpachn25_RS03010	COG0517	IMP dehydrogenase activity
vpachn25_RS03015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
vpachn25_RS03015	COG0519	Catalyzes the synthesis of GMP from XMP
vpachn25_RS03020	COG1757	Na H antiporter
vpachn25_RS03030	COG1584	GPR1 FUN34 yaaH family protein
vpachn25_RS03040	COG1115	amino acid carrier protein
vpachn25_RS03070	COG2873	o-acetylhomoserine
vpachn25_RS03075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
vpachn25_RS03095	COG3153	acetyltransferase
vpachn25_RS03095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
vpachn25_RS03100	COG0583	DNA-binding transcription factor activity
vpachn25_RS03210	COG0582	viral genome integration into host DNA
vpachn25_RS03220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
vpachn25_RS03225	COG2867	negative regulation of translational initiation
vpachn25_RS03230	COG2914	Belongs to the UPF0125 (RnfH) family
vpachn25_RS03235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vpachn25_RS03240	COG0497	DNA recombination
vpachn25_RS03250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
vpachn25_RS03255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
vpachn25_RS03265	COG0443	Heat shock 70 kDa protein
vpachn25_RS03270	COG0484	heat shock protein binding
vpachn25_RS03300	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
vpachn25_RS03315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
vpachn25_RS03315	COG0047	phosphoribosylformylglycinamidine synthase activity
vpachn25_RS03340	COG2195	Cleaves the N-terminal amino acid of tripeptides
vpachn25_RS03345	COG2252	PERMEase
vpachn25_RS03350	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
vpachn25_RS03355	COG1073	alpha beta
vpachn25_RS03365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
vpachn25_RS03370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
vpachn25_RS03375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
vpachn25_RS03380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
vpachn25_RS03380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
vpachn25_RS03400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
vpachn25_RS03405	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
vpachn25_RS03410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
vpachn25_RS03415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
vpachn25_RS03420	COG0142	geranyltranstransferase activity
vpachn25_RS03425	COG1722	exodeoxyribonuclease VII activity
vpachn25_RS03430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
vpachn25_RS03435	COG2885	chlorophyll binding
vpachn25_RS03440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
vpachn25_RS03440	COG0301	tRNA thio-modification
vpachn25_RS03445	COG0583	DNA-binding transcription factor activity
vpachn25_RS03455	COG2363	Small membrane protein
vpachn25_RS03460	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
vpachn25_RS03470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vpachn25_RS03475	COG1611	Belongs to the LOG family
vpachn25_RS03490	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
vpachn25_RS03490	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
vpachn25_RS03500	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
vpachn25_RS03505	COG1464	Belongs to the NlpA lipoprotein family
vpachn25_RS03510	COG2011	ABC-type metal ion transport system permease component
vpachn25_RS03515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
vpachn25_RS03520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
vpachn25_RS03530	COG1263	PTS System
vpachn25_RS03530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vpachn25_RS03535	COG0366	Alpha amylase catalytic
vpachn25_RS03550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
vpachn25_RS03555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
vpachn25_RS03560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
vpachn25_RS03565	COG0321	lipoyl(octanoyl) transferase activity
vpachn25_RS03570	COG2921	Belongs to the UPF0250 family
vpachn25_RS03575	COG1686	Belongs to the peptidase S11 family
vpachn25_RS03580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
vpachn25_RS03585	COG0772	Belongs to the SEDS family
vpachn25_RS03590	COG0768	penicillin binding
vpachn25_RS03595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
vpachn25_RS03600	COG0799	negative regulation of ribosome biogenesis
vpachn25_RS03605	COG1466	dna polymerase III delta subunit
vpachn25_RS03610	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
vpachn25_RS03615	COG0495	leucyl-tRNA aminoacylation
vpachn25_RS03620	COG2888	peptidyl-tyrosine sulfation
vpachn25_RS03625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
vpachn25_RS03630	COG4535	Mg2 and Co2 transporter CorC
vpachn25_RS03635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
vpachn25_RS03640	COG1702	phosphate starvation-inducible protein PhoH
vpachn25_RS03645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
vpachn25_RS03650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
vpachn25_RS03670	COG0012	GTP binding
vpachn25_RS03675	COG0193	aminoacyl-tRNA hydrolase activity
vpachn25_RS03680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
vpachn25_RS03685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
vpachn25_RS03690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
vpachn25_RS03695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
vpachn25_RS03700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
vpachn25_RS03705	COG2890	protein-(glutamine-N5) methyltransferase activity
vpachn25_RS03710	COG3094	Invasion gene expression up-regulator, SirB
vpachn25_RS03715	COG2912	Transglutaminase-like superfamily
vpachn25_RS03720	COG2877	3-deoxy-8-phosphooctulonate synthase activity
vpachn25_RS03725	COG0737	Belongs to the 5'-nucleotidase family
vpachn25_RS03735	COG3423	Transcriptional regulator
vpachn25_RS03740	COG2801	Transposase and inactivated derivatives
vpachn25_RS03745	COG2842	Transposition protein
vpachn25_RS03850	COG0640	Transcriptional regulator
vpachn25_RS03865	COG4373	Mu-like prophage FluMu protein gp28
vpachn25_RS03870	COG4383	Mu-like prophage protein gp29
vpachn25_RS03885	COG4397	Mu-like prophage major head subunit gpT
vpachn25_RS03905	COG4387	Mu-like prophage protein GP36
vpachn25_RS03925	COG4386	tail sheath protein
vpachn25_RS03940	COG3941	tape measure
vpachn25_RS03955	COG4384	Bacteriophage Mu Gp45 protein
vpachn25_RS03965	COG3299	homolog of phage Mu protein gp47
vpachn25_RS03970	COG3778	Protein conserved in bacteria
vpachn25_RS03985	COG0737	Belongs to the 5'-nucleotidase family
vpachn25_RS03995	COG1187	pseudouridine synthase activity
vpachn25_RS04000	COG2840	Smr protein MutS2
vpachn25_RS04035	COG2608	mercury ion transmembrane transporter activity
vpachn25_RS04035	COG2217	Heavy metal translocating P-type atpase
vpachn25_RS04045	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
vpachn25_RS04050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
vpachn25_RS04100	COG0784	Response regulator, receiver
vpachn25_RS04100	COG0835	chemotaxis
vpachn25_RS04105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
vpachn25_RS04110	COG1815	bacterial-type flagellum-dependent cell motility
vpachn25_RS04115	COG1558	bacterial-type flagellum-dependent cell motility
vpachn25_RS04125	COG1749	Flagellar hook protein flgE
vpachn25_RS04130	COG4787	bacterial-type flagellum-dependent cell motility
vpachn25_RS04140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
vpachn25_RS04145	COG1706	bacterial-type flagellum-dependent cell motility
vpachn25_RS04150	COG3951	Flagellar rod assembly protein muramidase FlgJ
vpachn25_RS04150	COG1705	Flagellar rod assembly protein muramidase FlgJ
vpachn25_RS04160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vpachn25_RS04170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vpachn25_RS04175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vpachn25_RS04180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vpachn25_RS04185	COG2190	(PTS) system
vpachn25_RS04190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
vpachn25_RS04195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
vpachn25_RS04200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
vpachn25_RS04205	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
vpachn25_RS04210	COG3115	cell septum assembly
vpachn25_RS04215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
vpachn25_RS04235	COG0330	HflC and HflK could
vpachn25_RS04240	COG2194	sulfuric ester hydrolase activity
vpachn25_RS04260	COG1215	transferase activity, transferring glycosyl groups
vpachn25_RS04265	COG1215	transferase activity, transferring glycosyl groups
vpachn25_RS04270	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
vpachn25_RS04275	COG0457	Tetratricopeptide repeat
vpachn25_RS04275	COG3118	belongs to the thioredoxin family
vpachn25_RS04280	COG3118	belongs to the thioredoxin family
vpachn25_RS04285	COG0300	oxidoreductase activity
vpachn25_RS04290	COG1090	epimerase
vpachn25_RS04315	COG0622	Phosphoesterase
vpachn25_RS04335	COG3710	Transcriptional regulator
vpachn25_RS04340	COG0326	Molecular chaperone. Has ATPase activity
vpachn25_RS04345	COG0563	adenylate kinase activity
vpachn25_RS04350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
vpachn25_RS04355	COG3104	oligopeptide transport
vpachn25_RS04360	COG0250	Participates in transcription elongation, termination and antitermination
vpachn25_RS04365	COG0367	asparagine synthase
vpachn25_RS04370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
vpachn25_RS04370	COG4651	solute:proton antiporter activity
vpachn25_RS04375	COG1846	Transcriptional regulator
vpachn25_RS04375	COG1940	carbohydrate kinase activity
vpachn25_RS04380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
vpachn25_RS04385	COG1263	PTS System
vpachn25_RS04385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vpachn25_RS04390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
vpachn25_RS04395	COG0735	belongs to the Fur family
vpachn25_RS04415	COG0596	Alpha beta hydrolase
vpachn25_RS04420	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
vpachn25_RS04425	COG0033	Phosphoglucomutase
vpachn25_RS04435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
vpachn25_RS04450	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
vpachn25_RS04455	COG1053	succinate dehydrogenase
vpachn25_RS04460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
vpachn25_RS04465	COG0567	Dehydrogenase, E1 component
vpachn25_RS04470	COG0508	dehydrogenase complex catalyzes the overall conversion of
vpachn25_RS04475	COG0045	succinate-CoA ligase (ADP-forming) activity
vpachn25_RS04485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
vpachn25_RS04490	COG1121	(ABC) transporter
vpachn25_RS04495	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
vpachn25_RS04500	COG4977	sequence-specific DNA binding
vpachn25_RS04505	COG1918	ferrous iron import across plasma membrane
vpachn25_RS04525	COG0018	arginyl-trna synthetase
vpachn25_RS04530	COG3102	Protein conserved in bacteria
vpachn25_RS04545	COG0788	formyltetrahydrofolate deformylase activity
vpachn25_RS04550	COG1199	ATP-dependent helicase activity
vpachn25_RS04555	COG1214	PFAM Peptidase M22, glycoprotease
vpachn25_RS04570	COG2267	carboxylic ester hydrolase activity
vpachn25_RS04575	COG0318	PFAM AMP-dependent synthetase and ligase
vpachn25_RS04580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
vpachn25_RS04585	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
vpachn25_RS04590	COG2894	cell division
vpachn25_RS04595	COG0850	regulation of cytokinetic process
vpachn25_RS04600	COG3100	YcgL domain-containing protein
vpachn25_RS04605	COG2951	lytic endotransglycosylase activity
vpachn25_RS04610	COG0583	DNA-binding transcription factor activity
vpachn25_RS04615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
vpachn25_RS04620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
vpachn25_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
vpachn25_RS04650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
vpachn25_RS04675	COG2986	histidine ammonia-lyase
vpachn25_RS04680	COG1216	Glycosyl transferase, family 2
vpachn25_RS04685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
vpachn25_RS04700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
vpachn25_RS04705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
vpachn25_RS04740	COG1253	flavin adenine dinucleotide binding
vpachn25_RS04745	COG0513	Belongs to the DEAD box helicase family
vpachn25_RS04750	COG0569	domain protein
vpachn25_RS04755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
vpachn25_RS04770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
vpachn25_RS04775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
vpachn25_RS04780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
vpachn25_RS04785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
vpachn25_RS04795	COG2204	response regulator
vpachn25_RS04810	COG0544	peptidyl-prolyl cis-trans isomerase activity
vpachn25_RS04820	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
vpachn25_RS04825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
vpachn25_RS04830	COG0776	regulation of translation
vpachn25_RS04835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
vpachn25_RS04840	COG1555	photosystem II stabilization
vpachn25_RS04855	COG0232	Belongs to the dGTPase family. Type 2 subfamily
vpachn25_RS04860	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
vpachn25_RS04865	COG0436	Aminotransferase
vpachn25_RS04870	COG1169	isochorismate synthase
vpachn25_RS04875	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
vpachn25_RS04880	COG0596	Alpha beta hydrolase
vpachn25_RS04885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
vpachn25_RS04905	COG2855	membrane
vpachn25_RS04910	COG0477	Major facilitator Superfamily
vpachn25_RS04950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vpachn25_RS04955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vpachn25_RS04980	COG1522	sequence-specific DNA binding
vpachn25_RS04990	COG1946	Acyl-CoA thioesterase
vpachn25_RS04995	COG3126	Type III secretion system lipoprotein chaperone (YscW)
vpachn25_RS05010	COG2199	diguanylate cyclase activity
vpachn25_RS05020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
vpachn25_RS05025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
vpachn25_RS05030	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
vpachn25_RS05035	COG0516	GMP reductase activity
vpachn25_RS05035	COG0517	IMP dehydrogenase activity
vpachn25_RS05060	COG0537	adenosine 5'-monophosphoramidase activity
vpachn25_RS05085	COG3150	esterase
vpachn25_RS05090	COG1252	NADH dehydrogenase
vpachn25_RS05115	COG4591	ABC-type transport system involved in lipoprotein release permease component
vpachn25_RS05120	COG1136	(ABC) transporter
vpachn25_RS05125	COG4591	ABC-type transport system involved in lipoprotein release permease component
vpachn25_RS05135	COG0658	competence protein
vpachn25_RS05135	COG2333	competence protein COMEC
vpachn25_RS05140	COG1132	(ABC) transporter
vpachn25_RS05145	COG1663	tetraacyldisaccharide 4'-kinase activity
vpachn25_RS05155	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
vpachn25_RS05160	COG2719	SpoVR family
vpachn25_RS05165	COG2718	Belongs to the UPF0229 family
vpachn25_RS05170	COG2766	serine protein kinase
vpachn25_RS05175	COG3013	Belongs to the UPF0304 family
vpachn25_RS05185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
vpachn25_RS05195	COG1882	Formate acetyltransferase
vpachn25_RS05235	COG0708	Exodeoxyribonuclease III
vpachn25_RS05305	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
vpachn25_RS05325	COG4695	Portal protein
vpachn25_RS05375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
vpachn25_RS05455	COG3923	Primosomal replication protein n
vpachn25_RS05460	COG0730	response to heat
vpachn25_RS05465	COG1199	ATP-dependent helicase activity
vpachn25_RS05470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
vpachn25_RS05475	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
vpachn25_RS05480	COG1187	pseudouridine synthase activity
vpachn25_RS05490	COG1278	Cold shock
vpachn25_RS05495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
vpachn25_RS05500	COG0542	response to heat
vpachn25_RS05510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
vpachn25_RS05515	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
vpachn25_RS05520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
vpachn25_RS05530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
vpachn25_RS05540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
vpachn25_RS05545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
vpachn25_RS05550	COG0297	glycogen (starch) synthase activity
vpachn25_RS05570	COG3070	regulator of competence-specific genes
vpachn25_RS05575	COG1609	Transcriptional regulator
vpachn25_RS05580	COG3381	protein complex oligomerization
vpachn25_RS05585	COG0745	RESPONSE REGULATOR receiver
vpachn25_RS05590	COG1434	Gram-negative-bacterium-type cell wall biogenesis
vpachn25_RS05595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
vpachn25_RS05600	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
vpachn25_RS05605	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
vpachn25_RS05610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
vpachn25_RS05625	COG0189	ligase activity
vpachn25_RS05625	COG4067	protein conserved in archaea
vpachn25_RS05630	COG0500	methyltransferase
vpachn25_RS05635	COG4106	trans-aconitate 2-methyltransferase activity
vpachn25_RS05645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
vpachn25_RS05650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
vpachn25_RS05655	COG0840	transmembrane signaling receptor activity
vpachn25_RS05660	COG0632	four-way junction helicase activity
vpachn25_RS05665	COG2255	four-way junction helicase activity
vpachn25_RS05670	COG1271	oxidase subunit
vpachn25_RS05675	COG1294	oxidase, subunit
vpachn25_RS05680	COG4890	Cyd operon protein YbgT
vpachn25_RS05690	COG0824	Thioesterase
vpachn25_RS05695	COG0811	peptide transport
vpachn25_RS05710	COG0823	Involved in the tonB-independent uptake of proteins
vpachn25_RS05715	COG2885	chlorophyll binding
vpachn25_RS05720	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
vpachn25_RS05725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
vpachn25_RS05735	COG3766	membrane
vpachn25_RS05745	COG0754	glutathionylspermidine amidase activity
vpachn25_RS05755	COG5002	protein histidine kinase activity
vpachn25_RS05755	COG0784	Response regulator, receiver
vpachn25_RS05770	COG0582	viral genome integration into host DNA
vpachn25_RS05845	COG1104	cysteine desulfurase activity
vpachn25_RS05895	COG0840	transmembrane signaling receptor activity
vpachn25_RS05900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vpachn25_RS05905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vpachn25_RS05930	COG3568	Endonuclease Exonuclease Phosphatase
vpachn25_RS05945	COG0583	DNA-binding transcription factor activity
vpachn25_RS05955	COG0686	Belongs to the AlaDH PNT family
vpachn25_RS05965	COG1674	ftsk spoiiie
vpachn25_RS05970	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
vpachn25_RS05975	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
vpachn25_RS05980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
vpachn25_RS05995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
vpachn25_RS06000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
vpachn25_RS06005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
vpachn25_RS06010	COG0156	8-amino-7-oxononanoate synthase activity
vpachn25_RS06020	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
vpachn25_RS06025	COG0501	Belongs to the peptidase M48B family
vpachn25_RS06035	COG0300	oxidoreductase activity
vpachn25_RS06050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
vpachn25_RS06070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
vpachn25_RS06075	COG2915	High frequency lysogenization protein hflD homolog
vpachn25_RS06080	COG0482	sulfurtransferase activity
vpachn25_RS06090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
vpachn25_RS06100	COG1757	Na H antiporter
vpachn25_RS06115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
vpachn25_RS06120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
vpachn25_RS06125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
vpachn25_RS06130	COG0131	Imidazoleglycerol-phosphate dehydratase
vpachn25_RS06130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
vpachn25_RS06135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
vpachn25_RS06140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
vpachn25_RS06145	COG0107	imidazoleglycerol-phosphate synthase activity
vpachn25_RS06150	COG0140	phosphoribosyl-ATP diphosphatase activity
vpachn25_RS06150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
vpachn25_RS06155	COG3012	SEC-C Motif Domain Protein
vpachn25_RS06160	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
vpachn25_RS06165	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vpachn25_RS06170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
vpachn25_RS06175	COG0215	cysteine-tRNA ligase activity
vpachn25_RS06180	COG1435	thymidine kinase activity
vpachn25_RS06185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
vpachn25_RS06210	COG2116	formate transmembrane transporter activity
vpachn25_RS06215	COG0390	transport system, permease component
vpachn25_RS06220	COG4459	periplasmic nitrate reductase
vpachn25_RS06225	COG3005	denitrification pathway
vpachn25_RS06230	COG0243	molybdopterin cofactor binding
vpachn25_RS06245	COG1227	inorganic diphosphatase activity
vpachn25_RS06255	COG4172	Belongs to the ABC transporter superfamily
vpachn25_RS06265	COG4171	peptide transport system, permease
vpachn25_RS06280	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
vpachn25_RS06285	COG1842	Phage shock protein A
vpachn25_RS06295	COG1983	PspC domain protein
vpachn25_RS06300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vpachn25_RS06315	COG2818	Glycosylase
vpachn25_RS06325	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
vpachn25_RS06330	COG0626	cystathionine gamma-synthase activity
vpachn25_RS06340	COG0733	neurotransmitter:sodium symporter activity
vpachn25_RS06350	COG0564	pseudouridine synthase activity
vpachn25_RS06360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
vpachn25_RS06365	COG1151	hydroxylamine reductase activity
vpachn25_RS06370	COG3604	Transcriptional regulator
vpachn25_RS06380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
vpachn25_RS06385	COG4136	ATPase activity
vpachn25_RS06390	COG4135	transport system, permease component
vpachn25_RS06395	COG4134	Bacterial extracellular solute-binding protein
vpachn25_RS06400	COG0398	Pfam SNARE associated Golgi protein
vpachn25_RS06410	COG0493	'glutamate synthase
vpachn25_RS06435	COG3313	Fe-S protein
vpachn25_RS06460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
vpachn25_RS06480	COG1061	Type III restriction enzyme res subunit
vpachn25_RS06485	COG1187	pseudouridine synthase activity
vpachn25_RS06490	COG2814	Major facilitator Superfamily
vpachn25_RS06520	COG3005	denitrification pathway
vpachn25_RS06525	COG0702	epimerase
vpachn25_RS06530	COG0534	Mate efflux family protein
vpachn25_RS06535	COG4181	ATPase activity
vpachn25_RS06550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
vpachn25_RS06565	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
vpachn25_RS06570	COG3273	potassium ion transport
vpachn25_RS06570	COG2985	domain, Protein
vpachn25_RS06575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
vpachn25_RS06585	COG1737	Transcriptional regulator
vpachn25_RS06590	COG0076	glutamate decarboxylase activity
vpachn25_RS06600	COG2431	L-lysine efflux transmembrane transporter activity
vpachn25_RS06610	COG3070	regulator of competence-specific genes
vpachn25_RS06625	COG4191	Histidine kinase
vpachn25_RS06625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vpachn25_RS06635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
vpachn25_RS06640	COG3048	D-serine ammonia-lyase activity
vpachn25_RS06645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
vpachn25_RS06650	COG4988	ABC transporter
vpachn25_RS06655	COG0492	ferredoxin-NADP+ reductase activity
vpachn25_RS06680	COG0471	metal ion transport
vpachn25_RS06685	COG2949	membrane
vpachn25_RS06690	COG0281	malic enzyme
vpachn25_RS06695	COG1643	Atp-dependent helicase
vpachn25_RS06700	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
vpachn25_RS06715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
vpachn25_RS06750	COG0247	lactate metabolic process
vpachn25_RS06750	COG0277	FAD linked oxidase domain protein
vpachn25_RS06765	COG2986	histidine ammonia-lyase
vpachn25_RS06770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
vpachn25_RS06775	COG0010	Belongs to the arginase family
vpachn25_RS06780	COG1228	amidohydrolase
vpachn25_RS06785	COG2188	Transcriptional regulator
vpachn25_RS06800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
vpachn25_RS06810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
vpachn25_RS06820	COG0393	Putative heavy-metal-binding
vpachn25_RS06850	COG3706	GGDEF domain
vpachn25_RS06855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
vpachn25_RS06860	COG0072	phenylalanine-tRNA ligase activity
vpachn25_RS06860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vpachn25_RS06870	COG0776	regulation of translation
vpachn25_RS06880	COG0500	methyltransferase
vpachn25_RS06885	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
vpachn25_RS06890	COG0295	cytidine deaminase activity
vpachn25_RS06895	COG1346	cytolysis
vpachn25_RS06900	COG1380	Effector of murein hydrolase LrgA
vpachn25_RS06905	COG2925	Exonuclease
vpachn25_RS06910	COG1823	symporter activity
vpachn25_RS06915	COG0702	epimerase
vpachn25_RS06920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
vpachn25_RS06925	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
vpachn25_RS06945	COG2988	succinylglutamate desuccinylase activity
vpachn25_RS06950	COG4139	cobalamin transport
vpachn25_RS06955	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
vpachn25_RS06975	COG0583	DNA-binding transcription factor activity
vpachn25_RS06985	COG1451	nucleotide metabolic process
vpachn25_RS06990	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
vpachn25_RS07020	COG3938	Belongs to the proline racemase family
vpachn25_RS07035	COG2423	ornithine cyclodeaminase activity
vpachn25_RS07040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
vpachn25_RS07045	COG3842	ATPase activity
vpachn25_RS07050	COG1176	ABC-type spermidine putrescine transport system, permease component I
vpachn25_RS07055	COG1177	transmembrane transport
vpachn25_RS07065	COG3291	Pkd domain containing protein
vpachn25_RS07080	COG0444	Belongs to the ABC transporter superfamily
vpachn25_RS07085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vpachn25_RS07090	COG0601	transmembrane transport
vpachn25_RS07100	COG0813	purine-nucleoside phosphorylase activity
vpachn25_RS07120	COG2195	Cleaves the N-terminal amino acid of tripeptides
vpachn25_RS07135	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
vpachn25_RS07145	COG0625	glutathione transferase activity
vpachn25_RS07185	COG1280	lysine exporter protein (LysE YggA)
vpachn25_RS07190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
vpachn25_RS07210	COG1757	Na H antiporter
vpachn25_RS07215	COG0174	glutamine synthetase
vpachn25_RS07220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
vpachn25_RS07225	COG1917	Cupin 2, conserved barrel domain protein
vpachn25_RS07225	COG1396	sequence-specific DNA binding
vpachn25_RS07230	COG1012	belongs to the aldehyde dehydrogenase family
vpachn25_RS07235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
vpachn25_RS07245	COG2957	Belongs to the agmatine deiminase family
vpachn25_RS07250	COG1012	belongs to the aldehyde dehydrogenase family
vpachn25_RS07255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
vpachn25_RS07260	COG1227	inorganic diphosphatase activity
vpachn25_RS07265	COG2771	luxR family
vpachn25_RS07265	COG2200	EAL domain
vpachn25_RS07280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
vpachn25_RS07295	COG1846	Transcriptional regulator
vpachn25_RS07300	COG2315	Protein conserved in bacteria
vpachn25_RS07320	COG0110	maltose O-acetyltransferase activity
vpachn25_RS07335	COG4999	Histidine kinase
vpachn25_RS07335	COG2205	protein histidine kinase activity
vpachn25_RS07335	COG3850	Histidine kinase
vpachn25_RS07335	COG3437	response regulator, receiver
vpachn25_RS07350	COG3063	Type IV pilus biogenesis stability protein PilW
vpachn25_RS07355	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
vpachn25_RS07365	COG0531	amino acid
vpachn25_RS07370	COG1560	Kdo2-lipid A biosynthetic process
vpachn25_RS07375	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
vpachn25_RS07380	COG1280	lysine exporter protein (LysE YggA)
vpachn25_RS07390	COG1115	amino acid carrier protein
vpachn25_RS07410	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
vpachn25_RS07420	COG0814	amino acid
vpachn25_RS07440	COG1132	(ABC) transporter
vpachn25_RS07445	COG1132	(ABC) transporter
vpachn25_RS07475	COG0443	Heat shock 70 kDa protein
vpachn25_RS07515	COG0243	molybdopterin cofactor binding
vpachn25_RS07520	COG0437	4 iron, 4 sulfur cluster binding
vpachn25_RS07525	COG3302	dmso reductase anchor subunit
vpachn25_RS07535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
vpachn25_RS07535	COG2221	Nitrite and sulphite reductase 4Fe-4S
vpachn25_RS07540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
vpachn25_RS07545	COG1643	Atp-dependent helicase
vpachn25_RS07560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
vpachn25_RS07570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
vpachn25_RS07575	COG1215	transferase activity, transferring glycosyl groups
vpachn25_RS07580	COG0438	transferase activity, transferring glycosyl groups
vpachn25_RS07620	COG2204	response regulator
vpachn25_RS07650	COG1793	dna ligase
vpachn25_RS07660	COG0534	Mate efflux family protein
vpachn25_RS07665	COG0307	riboflavin synthase, alpha
vpachn25_RS07675	COG3001	Fructosamine kinase
vpachn25_RS07680	COG2201	protein-glutamate methylesterase activity
vpachn25_RS07685	COG3706	GGDEF domain
vpachn25_RS07695	COG0791	NLP P60 protein
vpachn25_RS07700	COG0840	transmembrane signaling receptor activity
vpachn25_RS07735	COG3148	PFAM DTW domain containing protein
vpachn25_RS07740	COG1940	carbohydrate kinase activity
vpachn25_RS07750	COG0303	'Molybdopterin
vpachn25_RS07755	COG0746	molybdenum cofactor guanylyltransferase activity
vpachn25_RS07760	COG3842	ATPase activity
vpachn25_RS07775	COG2204	response regulator
vpachn25_RS07780	COG4191	Histidine kinase
vpachn25_RS07785	COG0488	(ABC) transporter
vpachn25_RS07790	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
vpachn25_RS07820	COG3383	formate dehydrogenase (NAD+) activity
vpachn25_RS07820	COG0243	molybdopterin cofactor binding
vpachn25_RS07825	COG0437	4 iron, 4 sulfur cluster binding
vpachn25_RS07850	COG0004	ammonium transporteR
vpachn25_RS07860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
vpachn25_RS07865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
vpachn25_RS07875	COG1177	transmembrane transport
vpachn25_RS07885	COG3842	ATPase activity
vpachn25_RS07905	COG0037	tRNA processing
vpachn25_RS07910	COG0589	response to stress
vpachn25_RS07915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
vpachn25_RS07930	COG2217	Heavy metal translocating P-type atpase
vpachn25_RS07940	COG2010	Cytochrome c
vpachn25_RS07955	COG3278	Belongs to the heme-copper respiratory oxidase family
vpachn25_RS07970	COG2205	protein histidine kinase activity
vpachn25_RS07970	COG0784	Response regulator, receiver
vpachn25_RS07990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
vpachn25_RS08030	COG3120	sequence-specific DNA binding
vpachn25_RS08035	COG1067	ATP-dependent peptidase activity
vpachn25_RS08040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
vpachn25_RS08055	COG0488	(ABC) transporter
vpachn25_RS08065	COG0116	Belongs to the methyltransferase superfamily
vpachn25_RS08065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
vpachn25_RS08075	COG0167	dihydroorotate dehydrogenase activity
vpachn25_RS08080	COG2902	Dehydrogenase
vpachn25_RS08085	COG0308	aminopeptidase N
vpachn25_RS08100	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
vpachn25_RS08215	COG4695	Portal protein
vpachn25_RS08300	COG1428	Deoxynucleoside kinase
vpachn25_RS08345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vpachn25_RS08345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vpachn25_RS08395	COG0308	aminopeptidase N
vpachn25_RS08410	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
vpachn25_RS08415	COG1956	GAF domain-containing protein
vpachn25_RS08420	COG1132	(ABC) transporter
vpachn25_RS08425	COG2995	paraquat-inducible protein a
vpachn25_RS08430	COG3008	intermembrane lipid transfer
vpachn25_RS08435	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
vpachn25_RS08435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
vpachn25_RS08455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
vpachn25_RS08460	COG1666	GTP binding
vpachn25_RS08470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vpachn25_RS08475	COG4597	amino acid ABC transporter
vpachn25_RS08480	COG0765	amino acid transport
vpachn25_RS08485	COG1126	abc transporter atp-binding protein
vpachn25_RS08490	COG0670	Belongs to the BI1 family
vpachn25_RS08500	COG2920	part of a sulfur-relay system
vpachn25_RS08505	COG1254	Belongs to the acylphosphatase family
vpachn25_RS08510	COG0840	transmembrane signaling receptor activity
vpachn25_RS08515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
vpachn25_RS08555	COG3706	GGDEF domain
vpachn25_RS08560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
vpachn25_RS08565	COG0602	queuosine metabolic process
vpachn25_RS08570	COG0561	phosphatase activity
vpachn25_RS08595	COG2828	Protein conserved in bacteria
vpachn25_RS08605	COG0372	Belongs to the citrate synthase family
vpachn25_RS08610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
vpachn25_RS08640	COG0730	response to heat
vpachn25_RS08660	COG0457	Tetratricopeptide repeat
vpachn25_RS08730	COG4790	Type iii secretion
vpachn25_RS08735	COG4794	Type iii secretion
vpachn25_RS08740	COG4791	protein targeting
vpachn25_RS08745	COG4792	protein secretion
vpachn25_RS08755	COG1073	alpha beta
vpachn25_RS08760	COG1073	alpha beta
vpachn25_RS08790	COG3177	Filamentation induced by cAMP protein fic
vpachn25_RS08810	COG4669	(LipO)protein
vpachn25_RS08880	COG1012	belongs to the aldehyde dehydrogenase family
vpachn25_RS08885	COG3284	Transcriptional regulator
vpachn25_RS08895	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
vpachn25_RS08900	COG0363	glucosamine-6-phosphate deaminase activity
vpachn25_RS08905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
vpachn25_RS08915	COG3290	protein histidine kinase activity
vpachn25_RS08930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vpachn25_RS08945	COG1858	cytochrome C peroxidase
vpachn25_RS08950	COG0527	aspartate kinase activity
vpachn25_RS08955	COG0662	Cupin 2, conserved barrel domain protein
vpachn25_RS08960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
vpachn25_RS08965	COG0456	acetyltransferase
vpachn25_RS08970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
vpachn25_RS08990	COG4176	ABC-type proline glycine betaine transport system permease component
vpachn25_RS08995	COG2113	Glycine betaine
vpachn25_RS09015	COG1028	Short-chain dehydrogenase reductase Sdr
vpachn25_RS09025	COG0745	RESPONSE REGULATOR receiver
vpachn25_RS09030	COG0642	Histidine kinase
vpachn25_RS09035	COG1368	sulfuric ester hydrolase activity
vpachn25_RS09045	COG0861	Integral membrane protein TerC family
vpachn25_RS09055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
vpachn25_RS09060	COG1328	CTP reductase activity
vpachn25_RS09065	COG1280	lysine exporter protein (LysE YggA)
vpachn25_RS09075	COG5001	Diguanylate cyclase
vpachn25_RS09075	COG3300	MHYT domain
vpachn25_RS09085	COG4191	Histidine kinase
vpachn25_RS09085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vpachn25_RS09090	COG0471	metal ion transport
vpachn25_RS09125	COG0583	DNA-binding transcription factor activity
vpachn25_RS09130	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
vpachn25_RS09190	COG0346	lactoylglutathione lyase activity
vpachn25_RS09250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
vpachn25_RS09260	COG3768	UPF0283 membrane protein
vpachn25_RS09280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
vpachn25_RS09285	COG2205	protein histidine kinase activity
vpachn25_RS09285	COG0784	Response regulator, receiver
vpachn25_RS09295	COG0494	nUDIX hydrolase
vpachn25_RS09300	COG0814	amino acid
vpachn25_RS09305	COG1760	l-serine dehydratase
vpachn25_RS09310	COG2200	EAL domain
vpachn25_RS09320	COG0720	synthase
vpachn25_RS09330	COG0017	Asparaginyl-tRNA synthetase
vpachn25_RS09340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
vpachn25_RS09355	COG1448	Aminotransferase
vpachn25_RS09380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
vpachn25_RS09385	COG1846	Transcriptional regulator
vpachn25_RS09410	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
vpachn25_RS09425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
vpachn25_RS09430	COG3108	Peptidase M15
vpachn25_RS09435	COG2989	Protein conserved in bacteria
vpachn25_RS09460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
vpachn25_RS09470	COG3088	subunit of a heme lyase
vpachn25_RS09470	COG4235	cytochrome complex assembly
vpachn25_RS09480	COG1138	Cytochrome C-type biogenesis protein
vpachn25_RS09485	COG3301	Polysulphide reductase, NrfD
vpachn25_RS09490	COG0437	4 iron, 4 sulfur cluster binding
vpachn25_RS09500	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
vpachn25_RS09520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
vpachn25_RS09525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
vpachn25_RS09530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
vpachn25_RS09535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
vpachn25_RS09550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
vpachn25_RS09575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
vpachn25_RS09600	COG0019	diaminopimelate decarboxylase activity
vpachn25_RS09640	COG0322	excinuclease ABC activity
vpachn25_RS09645	COG2197	response regulator
vpachn25_RS09650	COG0417	DNA replication proofreading
vpachn25_RS09660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
vpachn25_RS09665	COG3099	Belongs to the UPF0263 family
vpachn25_RS09670	COG1187	pseudouridine synthase activity
vpachn25_RS09680	COG0009	L-threonylcarbamoyladenylate synthase
vpachn25_RS09685	COG0613	PHP domain protein
vpachn25_RS09695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
vpachn25_RS09700	COG0512	Glutamine amidotransferase of anthranilate synthase
vpachn25_RS09705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
vpachn25_RS09710	COG0135	phosphoribosylanthranilate isomerase activity
vpachn25_RS09710	COG0134	indole-3-glycerol-phosphate synthase activity
vpachn25_RS09715	COG0133	tryptophan synthase activity
vpachn25_RS09720	COG0159	tryptophan synthase activity
vpachn25_RS09725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
vpachn25_RS09730	COG0318	PFAM AMP-dependent synthetase and ligase
vpachn25_RS09735	COG1301	dicarboxylic acid transport
vpachn25_RS09755	COG2917	probably involved in intracellular septation
vpachn25_RS09765	COG2350	Protein conserved in bacteria
vpachn25_RS09775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
vpachn25_RS09780	COG0583	DNA-binding transcription factor activity
vpachn25_RS09795	COG2203	Gaf domain
vpachn25_RS09795	COG4251	negative regulation of phosphorylation
vpachn25_RS09795	COG5001	Diguanylate cyclase
vpachn25_RS09795	COG3706	GGDEF domain
vpachn25_RS09800	COG1032	radical SAM domain protein
vpachn25_RS09805	COG0840	transmembrane signaling receptor activity
vpachn25_RS09810	COG0745	RESPONSE REGULATOR receiver
vpachn25_RS09815	COG5002	protein histidine kinase activity
vpachn25_RS09815	COG3850	Histidine kinase
vpachn25_RS09865	COG1335	isochorismatase
vpachn25_RS09870	COG0577	efflux transmembrane transporter activity
vpachn25_RS09870	COG1136	(ABC) transporter
vpachn25_RS09880	COG0577	efflux transmembrane transporter activity
vpachn25_RS09880	COG1136	(ABC) transporter
vpachn25_RS09890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vpachn25_RS09920	COG3118	belongs to the thioredoxin family
vpachn25_RS09925	COG4232	protein-disulfide reductase activity
vpachn25_RS09965	COG2863	cytochrome
vpachn25_RS09970	COG3258	Cytochrome c
vpachn25_RS09975	COG2995	paraquat-inducible protein a
vpachn25_RS09980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
vpachn25_RS09980	COG3008	intermembrane lipid transfer
vpachn25_RS09990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
vpachn25_RS10015	COG4166	transmembrane transport
vpachn25_RS10020	COG0284	orotidine-5'-phosphate decarboxylase activity
vpachn25_RS10025	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
vpachn25_RS10030	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
vpachn25_RS10040	COG0539	negative regulation of cytoplasmic translation
vpachn25_RS10045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
vpachn25_RS10050	COG0616	signal peptide processing
vpachn25_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
vpachn25_RS10070	COG0587	DNA-directed DNA polymerase activity
vpachn25_RS10075	COG0784	Response regulator, receiver
vpachn25_RS10075	COG0835	chemotaxis
vpachn25_RS10080	COG1940	carbohydrate kinase activity
vpachn25_RS10085	COG0469	pyruvate kinase activity
vpachn25_RS10090	COG4667	esterase of the alpha-beta hydrolase superfamily
vpachn25_RS10100	COG0733	neurotransmitter:sodium symporter activity
vpachn25_RS10110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vpachn25_RS10110	COG1263	PTS System
vpachn25_RS10115	COG0084	hydrolase, TatD family'
vpachn25_RS10125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
vpachn25_RS10130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
vpachn25_RS10160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
vpachn25_RS10165	COG0416	fatty acid biosynthetic process
vpachn25_RS10175	COG1399	metal-binding, possibly nucleic acid-binding protein
vpachn25_RS10180	COG0424	maF-like protein
vpachn25_RS10185	COG0564	pseudouridine synthase activity
vpachn25_RS10190	COG1530	ribonuclease E activity
vpachn25_RS10195	COG0659	secondary active sulfate transmembrane transporter activity
vpachn25_RS10200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
vpachn25_RS10205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
vpachn25_RS10215	COG0572	uridine kinase
vpachn25_RS10220	COG0489	protein tyrosine kinase activity
vpachn25_RS10225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vpachn25_RS10225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vpachn25_RS10235	COG2186	Transcriptional regulator
vpachn25_RS10240	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
vpachn25_RS10245	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
vpachn25_RS10250	COG0653	protein targeting
vpachn25_RS10255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
vpachn25_RS10260	COG2199	diguanylate cyclase activity
vpachn25_RS10260	COG2203	Gaf domain
vpachn25_RS10265	COG0366	Alpha amylase catalytic
vpachn25_RS10270	COG1122	ATPase activity
vpachn25_RS10275	COG4120	Belongs to the binding-protein-dependent transport system permease family
vpachn25_RS10285	COG3092	negative regulation of chromosome organization
vpachn25_RS10290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
vpachn25_RS10295	COG0280	phosphate acetyltransferase
vpachn25_RS10295	COG0857	belongs to the CobB CobQ family
vpachn25_RS10300	COG3174	membrane
vpachn25_RS10310	COG0435	Glutathione S-transferase
vpachn25_RS10320	COG0444	Belongs to the ABC transporter superfamily
vpachn25_RS10325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vpachn25_RS10330	COG0601	transmembrane transport
vpachn25_RS10340	COG0314	molybdopterin synthase activity
vpachn25_RS10345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
vpachn25_RS10350	COG0315	cyclic pyranopterin monophosphate synthase activity
vpachn25_RS10355	COG0521	Mo-molybdopterin cofactor biosynthetic process
vpachn25_RS10360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
vpachn25_RS10365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
vpachn25_RS10370	COG2198	Histidine kinase
vpachn25_RS10375	COG2204	response regulator
vpachn25_RS10380	COG0556	nucleotide-excision repair
vpachn25_RS10390	COG4657	Part of a membrane complex involved in electron transport
vpachn25_RS10400	COG4656	Part of a membrane complex involved in electron transport
vpachn25_RS10405	COG4658	electron transport chain
vpachn25_RS10410	COG4659	FMN binding
vpachn25_RS10415	COG4660	Part of a membrane complex involved in electron transport
vpachn25_RS10420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
vpachn25_RS10425	COG0346	lactoylglutathione lyase activity
vpachn25_RS10435	COG2885	chlorophyll binding
vpachn25_RS10440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
vpachn25_RS10445	COG2056	Na+-H+ antiporter family
vpachn25_RS10455	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
vpachn25_RS10475	COG1454	alcohol dehydrogenase
vpachn25_RS10475	COG1012	belongs to the aldehyde dehydrogenase family
vpachn25_RS10480	COG2095	MarC family integral membrane protein
vpachn25_RS10485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
vpachn25_RS10490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
vpachn25_RS10495	COG1757	Na H antiporter
vpachn25_RS10510	COG3081	Nucleoid-associated protein
vpachn25_RS10515	COG3082	Protein of unknown function (DUF1414)
vpachn25_RS10520	COG3083	sulfuric ester hydrolase activity
vpachn25_RS10530	COG0123	including yeast histone deacetylase and acetoin utilization protein
vpachn25_RS10545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
vpachn25_RS10550	COG0778	Nitroreductase
vpachn25_RS10555	COG1902	pentaerythritol trinitrate reductase activity
vpachn25_RS10555	COG0446	pyridine nucleotide-disulphide oxidoreductase
vpachn25_RS10560	COG0616	signal peptide processing
vpachn25_RS10565	COG0252	asparaginase activity
vpachn25_RS10570	COG3139	Protein of unknown function (DUF1315)
vpachn25_RS10580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vpachn25_RS10585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
vpachn25_RS10600	COG2226	methyltransferase
vpachn25_RS10615	COG1785	Belongs to the alkaline phosphatase family
vpachn25_RS10625	COG0346	lactoylglutathione lyase activity
vpachn25_RS10635	COG0668	transmembrane transport
vpachn25_RS10640	COG2983	Belongs to the UPF0260 family
vpachn25_RS10645	COG2261	transglycosylase associated protein
vpachn25_RS10660	COG3681	Belongs to the UPF0597 family
vpachn25_RS10665	COG0251	oxidation-reduction process
vpachn25_RS10670	COG0814	amino acid
vpachn25_RS10675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
vpachn25_RS10680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
vpachn25_RS10685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
vpachn25_RS10695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
vpachn25_RS10700	COG2832	Protein of unknown function (DUF454)
vpachn25_RS10705	COG0745	RESPONSE REGULATOR receiver
vpachn25_RS10710	COG0583	DNA-binding transcription factor activity
vpachn25_RS10715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
vpachn25_RS10720	COG1286	toxin biosynthetic process
vpachn25_RS10725	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
vpachn25_RS10730	COG0285	dihydrofolate synthase activity
vpachn25_RS10735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
vpachn25_RS10740	COG0101	tRNA pseudouridine synthase activity
vpachn25_RS10750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
vpachn25_RS10755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
vpachn25_RS10760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
vpachn25_RS10765	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
vpachn25_RS10765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
vpachn25_RS10780	COG3101	peptidyl-lysine hydroxylation
vpachn25_RS10785	COG2860	membrane
vpachn25_RS10790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
vpachn25_RS10795	COG2890	protein-(glutamine-N5) methyltransferase activity
vpachn25_RS10800	COG2840	Smr protein MutS2
vpachn25_RS10805	COG2062	phosphohistidine phosphatase, SixA
vpachn25_RS10820	COG1024	Enoyl-CoA hydratase
vpachn25_RS10820	COG1250	3-hydroxyacyl-CoA dehydrogenase
vpachn25_RS10825	COG0183	Belongs to the thiolase family
vpachn25_RS10840	COG2067	long-chain fatty acid transport protein
vpachn25_RS10850	COG2853	Lipoprotein
vpachn25_RS10865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
vpachn25_RS10870	COG1138	Cytochrome C-type biogenesis protein
vpachn25_RS10875	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
vpachn25_RS10880	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
vpachn25_RS10885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
vpachn25_RS10890	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
vpachn25_RS10895	COG4133	protoheme IX ABC transporter activity
vpachn25_RS10905	COG0835	chemotaxis
vpachn25_RS10915	COG1192	Involved in chromosome partitioning
vpachn25_RS10920	COG2201	protein-glutamate methylesterase activity
vpachn25_RS10925	COG0784	Response regulator, receiver
vpachn25_RS10925	COG0643	Histidine kinase
vpachn25_RS10925	COG2198	Histidine kinase
vpachn25_RS10930	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
vpachn25_RS10970	COG1987	bacterial-type flagellum assembly
vpachn25_RS11020	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
vpachn25_RS11030	COG1677	Flagellar hook-basal body complex protein FliE
vpachn25_RS11050	COG1516	flagellar protein fliS
vpachn25_RS11060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
vpachn25_RS11065	COG1334	flagellar protein FlaG
vpachn25_RS11070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vpachn25_RS11075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vpachn25_RS11085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vpachn25_RS11090	COG2837	iron assimilation
vpachn25_RS11115	COG1393	Belongs to the ArsC family
vpachn25_RS11120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
vpachn25_RS11135	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
vpachn25_RS11140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
vpachn25_RS11145	COG2716	regulation of RNA biosynthetic process
vpachn25_RS11150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
vpachn25_RS11165	COG4783	chaperone-mediated protein folding
vpachn25_RS11170	COG1393	Belongs to the ArsC family
vpachn25_RS11190	COG2233	PERMEase
vpachn25_RS11195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
vpachn25_RS11200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
vpachn25_RS11205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
vpachn25_RS11210	COG0121	glutamine amidotransferase
vpachn25_RS11215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
vpachn25_RS11220	COG1960	acyl-CoA dehydrogenase activity
vpachn25_RS11235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
vpachn25_RS11240	COG0328	RNA-DNA hybrid ribonuclease activity
vpachn25_RS11245	COG2226	methyltransferase
vpachn25_RS11250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
vpachn25_RS11255	COG0741	lytic transglycosylase activity
vpachn25_RS11255	COG1388	LysM domain
vpachn25_RS11265	COG3021	interspecies interaction between organisms
vpachn25_RS11270	COG0347	Belongs to the P(II) protein family
vpachn25_RS11280	COG0037	tRNA processing
vpachn25_RS11285	COG0825	malonyl-CoA metabolic process
vpachn25_RS11290	COG0587	DNA-directed DNA polymerase activity
vpachn25_RS11295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
vpachn25_RS11300	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vpachn25_RS11305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vpachn25_RS11310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
vpachn25_RS11315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vpachn25_RS11320	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
vpachn25_RS11330	COG0750	zinc metalloprotease
vpachn25_RS11335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
vpachn25_RS11340	COG0575	Belongs to the CDS family
vpachn25_RS11345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
vpachn25_RS11350	COG0233	cytoplasmic translational termination
vpachn25_RS11355	COG0528	UMP kinase activity
vpachn25_RS11360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
vpachn25_RS11365	COG0052	Belongs to the universal ribosomal protein uS2 family
vpachn25_RS11370	COG0024	Methionine aminopeptidase
vpachn25_RS11375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
vpachn25_RS11385	COG0564	pseudouridine synthase activity
vpachn25_RS11390	COG3098	single-species biofilm formation
vpachn25_RS11410	COG1671	Belongs to the UPF0178 family
vpachn25_RS11415	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
vpachn25_RS11420	COG0254	rRNA binding
vpachn25_RS11425	COG1720	tRNA m6t6A37 methyltransferase activity
vpachn25_RS11430	COG0442	prolyl-tRNA aminoacylation
vpachn25_RS11450	COG0733	neurotransmitter:sodium symporter activity
vpachn25_RS11465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
vpachn25_RS11470	COG0514	ATP-dependent DNA helicase (RecQ)
vpachn25_RS11475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
vpachn25_RS11490	COG1477	protein flavinylation
vpachn25_RS11495	COG2871	sodium ion transport
vpachn25_RS11500	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vpachn25_RS11505	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vpachn25_RS11510	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vpachn25_RS11515	COG1805	sodium ion transport
vpachn25_RS11520	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vpachn25_RS11525	COG0271	Belongs to the BolA IbaG family
vpachn25_RS11530	COG2813	Specifically methylates the guanine in position
vpachn25_RS11535	COG3056	Lipoprotein
vpachn25_RS11555	COG1595	DNA-templated transcription, initiation
vpachn25_RS11580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
vpachn25_RS11585	COG0693	protein deglycase activity
vpachn25_RS11590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
vpachn25_RS11600	COG2166	iron-sulfur cluster assembly
vpachn25_RS11605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
vpachn25_RS11610	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
vpachn25_RS11620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
vpachn25_RS11620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
vpachn25_RS11625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
vpachn25_RS11630	COG1074	ATP-dependent DNA helicase activity
vpachn25_RS11640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
vpachn25_RS11660	COG3141	response to X-ray
vpachn25_RS11665	COG2171	N-acyltransferase activity
vpachn25_RS11670	COG0584	glycerophosphoryl diester phosphodiesterase
vpachn25_RS11675	COG2271	Major facilitator Superfamily
vpachn25_RS11680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
vpachn25_RS11685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
vpachn25_RS11690	COG1349	DNA-binding transcription factor activity
vpachn25_RS11695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
vpachn25_RS11700	COG0598	Magnesium transport protein CorA
vpachn25_RS11720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vpachn25_RS11725	COG1609	Transcriptional regulator
vpachn25_RS11730	COG2211	Major facilitator Superfamily
vpachn25_RS11745	COG2017	converts alpha-aldose to the beta-anomer
vpachn25_RS11750	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
vpachn25_RS11760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
vpachn25_RS11765	COG1609	Transcriptional regulator
vpachn25_RS11770	COG3250	beta-galactosidase activity
vpachn25_RS11775	COG2731	YhcH YjgK YiaL family protein
vpachn25_RS11780	COG0531	amino acid
vpachn25_RS11785	COG0583	DNA-binding transcription factor activity
vpachn25_RS11845	COG4964	Belongs to the GSP D family
vpachn25_RS11870	COG2169	Transcriptional regulator
vpachn25_RS11875	COG1022	Amp-dependent synthetase and ligase
vpachn25_RS11885	COG0583	DNA-binding transcription factor activity
vpachn25_RS11890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
vpachn25_RS11895	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
vpachn25_RS11905	COG0560	Phosphoserine phosphatase
vpachn25_RS11915	COG0813	purine-nucleoside phosphorylase activity
vpachn25_RS11920	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
vpachn25_RS11925	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
vpachn25_RS11930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
vpachn25_RS11935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
vpachn25_RS11940	COG0084	hydrolase, TatD family'
vpachn25_RS11950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
vpachn25_RS12025	COG2003	Belongs to the UPF0758 family
vpachn25_RS12050	COG0714	Associated with various cellular activities
vpachn25_RS12065	COG0629	single-stranded DNA binding
vpachn25_RS12085	COG0464	growth
vpachn25_RS12090	COG1404	Belongs to the peptidase S8 family
vpachn25_RS12100	COG1074	ATP-dependent DNA helicase activity
vpachn25_RS12120	COG0681	Belongs to the peptidase S26 family
vpachn25_RS12135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
vpachn25_RS12255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
vpachn25_RS12305	COG0551	DNA topoisomerase type I activity
vpachn25_RS12305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
vpachn25_RS12385	COG3153	acetyltransferase
vpachn25_RS12390	COG3154	lipid carrier protein
vpachn25_RS12400	COG0826	peptidase U32
vpachn25_RS12405	COG0826	peptidase U32
vpachn25_RS12410	COG0534	Mate efflux family protein
vpachn25_RS12425	COG1185	polyribonucleotide nucleotidyltransferase activity
vpachn25_RS12430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
vpachn25_RS12435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
vpachn25_RS12440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
vpachn25_RS12445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
vpachn25_RS12450	COG0195	Participates in both transcription termination and antitermination
vpachn25_RS12455	COG0779	Required for maturation of 30S ribosomal subunits
vpachn25_RS12470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
vpachn25_RS12480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
vpachn25_RS12485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
vpachn25_RS12495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
vpachn25_RS12500	COG1534	Rna-binding protein
vpachn25_RS12505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
vpachn25_RS12510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
vpachn25_RS12515	COG2027	D-alanyl-D-alanine carboxypeptidase
vpachn25_RS12525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
vpachn25_RS12530	COG0739	heme binding
vpachn25_RS12535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vpachn25_RS12545	COG0316	Belongs to the HesB IscA family
vpachn25_RS12550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
vpachn25_RS12555	COG0628	permease
vpachn25_RS12560	COG2813	Specifically methylates the guanine in position
vpachn25_RS12565	COG2198	Histidine kinase
vpachn25_RS12565	COG2205	protein histidine kinase activity
vpachn25_RS12565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vpachn25_RS12565	COG0784	Response regulator, receiver
vpachn25_RS12570	COG0747	negative chemotaxis
vpachn25_RS12580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vpachn25_RS12585	COG0444	Belongs to the ABC transporter superfamily
vpachn25_RS12590	COG4608	Belongs to the ABC transporter superfamily
vpachn25_RS12600	COG2971	BadF BadG BcrA BcrD
vpachn25_RS12615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
vpachn25_RS12620	COG3842	ATPase activity
vpachn25_RS12630	COG1840	ABC-type Fe3 transport system, periplasmic component
vpachn25_RS12635	COG0004	ammonium transporteR
vpachn25_RS12645	COG3112	Uncharacterised protein family (UPF0231)
vpachn25_RS12650	COG1049	propionate catabolic process, 2-methylcitrate cycle
vpachn25_RS12655	COG1752	Esterase of the alpha-beta hydrolase superfamily
vpachn25_RS12660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
vpachn25_RS12665	COG1643	Atp-dependent helicase
vpachn25_RS12670	COG1489	DNA binding
vpachn25_RS12680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
vpachn25_RS12690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
vpachn25_RS12695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
vpachn25_RS12700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
vpachn25_RS12705	COG1560	Kdo2-lipid A biosynthetic process
vpachn25_RS12710	COG0842	Transport permease protein
vpachn25_RS12715	COG1131	(ABC) transporter
vpachn25_RS12720	COG0659	secondary active sulfate transmembrane transporter activity
vpachn25_RS12725	COG0288	reversible hydration of carbon dioxide
vpachn25_RS12740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
vpachn25_RS12745	COG0508	dehydrogenase complex catalyzes the overall conversion of
vpachn25_RS12750	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
vpachn25_RS12755	COG2186	Transcriptional regulator
vpachn25_RS12765	COG0157	Belongs to the NadC ModD family
vpachn25_RS12770	COG4969	Belongs to the N-Me-Phe pilin family
vpachn25_RS12775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
vpachn25_RS12780	COG1459	type II secretion system
vpachn25_RS12790	COG0237	dephospho-CoA kinase activity
vpachn25_RS12795	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
vpachn25_RS12800	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
vpachn25_RS12805	COG0335	large ribosomal subunit rRNA binding
vpachn25_RS12810	COG0336	Belongs to the RNA methyltransferase TrmD family
vpachn25_RS12815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
vpachn25_RS12820	COG0228	four-way junction DNA binding
vpachn25_RS12825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
vpachn25_RS12830	COG4137	Cytochrome C assembly protein
vpachn25_RS12835	COG4536	flavin adenine dinucleotide binding
vpachn25_RS12840	COG1854	S-ribosylhomocysteine lyase activity
vpachn25_RS12850	COG2918	glutathione biosynthetic process
vpachn25_RS12855	COG0612	Peptidase, M16
vpachn25_RS12860	COG1238	metal cluster binding
vpachn25_RS12870	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
vpachn25_RS12875	COG5016	pyruvate
vpachn25_RS12875	COG0511	ligase activity, forming carbon-carbon bonds
vpachn25_RS12880	COG3630	sodium ion export across plasma membrane
vpachn25_RS12940	COG0527	aspartate kinase activity
vpachn25_RS12945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
vpachn25_RS12950	COG2137	regulation of response to DNA damage stimulus
vpachn25_RS12955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
vpachn25_RS12960	COG1546	Belongs to the CinA family
vpachn25_RS12965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
vpachn25_RS12970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
vpachn25_RS12980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
vpachn25_RS12985	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
vpachn25_RS12990	COG0585	pseudouridine synthase activity
vpachn25_RS12995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
vpachn25_RS13000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
vpachn25_RS13005	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
vpachn25_RS13010	COG0148	phosphopyruvate hydratase activity
vpachn25_RS13015	COG0504	CTP synthase activity
vpachn25_RS13020	COG3956	TIGRFAM MazG family protein
vpachn25_RS13025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
vpachn25_RS13030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
vpachn25_RS13040	COG0736	holo-[acyl-carrier-protein] synthase activity
vpachn25_RS13045	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
vpachn25_RS13050	COG1381	Involved in DNA repair and RecF pathway recombination
vpachn25_RS13055	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
vpachn25_RS13060	COG0571	ribonuclease III activity
vpachn25_RS13070	COG0481	GTPase activity
vpachn25_RS13075	COG3086	response to oxidative stress
vpachn25_RS13085	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
vpachn25_RS13090	COG1595	DNA-templated transcription, initiation
vpachn25_RS13095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
vpachn25_RS13100	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
vpachn25_RS13105	COG0354	folic acid binding
vpachn25_RS13120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
vpachn25_RS13125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
vpachn25_RS13130	COG3079	Belongs to the UPF0149 family
vpachn25_RS13135	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
vpachn25_RS13145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
vpachn25_RS13150	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
vpachn25_RS13155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
vpachn25_RS13165	COG0583	DNA-binding transcription factor activity
vpachn25_RS13175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
vpachn25_RS13180	COG0668	transmembrane transport
vpachn25_RS13185	COG0191	fructose-bisphosphate aldolase activity
vpachn25_RS13190	COG0126	phosphoglycerate kinase activity
vpachn25_RS13195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
vpachn25_RS13200	COG4771	TonB-dependent receptor
vpachn25_RS13205	COG0583	DNA-binding transcription factor activity
vpachn25_RS13210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
vpachn25_RS13220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
vpachn25_RS13230	COG3091	SprT-like family
vpachn25_RS13235	COG2356	endonuclease I
vpachn25_RS13240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
vpachn25_RS13245	COG0189	ligase activity
vpachn25_RS13250	COG1678	Uncharacterized ACR, COG1678
vpachn25_RS13255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
vpachn25_RS13270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
vpachn25_RS13275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
vpachn25_RS13280	COG0762	integral membrane protein
vpachn25_RS13285	COG1872	DUF167
vpachn25_RS13295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
vpachn25_RS13300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
vpachn25_RS13305	COG2066	Belongs to the glutaminase family
vpachn25_RS13315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
vpachn25_RS13325	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
vpachn25_RS13330	COG0741	lytic transglycosylase activity
vpachn25_RS13370	COG0840	transmembrane signaling receptor activity
vpachn25_RS13400	COG1012	belongs to the aldehyde dehydrogenase family
vpachn25_RS13445	COG3437	response regulator, receiver
vpachn25_RS13455	COG3394	polysaccharide catabolic process
vpachn25_RS13460	COG1486	melibiose metabolic process
vpachn25_RS13465	COG1447	Phosphotransferase system cellobiose-specific component IIA
vpachn25_RS13470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
vpachn25_RS13475	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
vpachn25_RS13480	COG0726	polysaccharide deacetylase
vpachn25_RS13490	COG1028	Short-chain dehydrogenase reductase Sdr
vpachn25_RS13505	COG0795	lipopolysaccharide-transporting ATPase activity
vpachn25_RS13510	COG0795	lipopolysaccharide-transporting ATPase activity
vpachn25_RS13515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
vpachn25_RS13520	COG2927	DNA polymerase III (CHI subunit)
vpachn25_RS13525	COG0525	valine-tRNA ligase activity
vpachn25_RS13550	COG2235	arginine
vpachn25_RS13555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
vpachn25_RS13560	COG0540	Belongs to the ATCase OTCase family
vpachn25_RS13565	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
vpachn25_RS13570	COG0251	oxidation-reduction process
vpachn25_RS13575	COG0204	Acyl-transferase
vpachn25_RS13580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
vpachn25_RS13585	COG5007	Belongs to the BolA IbaG family
vpachn25_RS13595	COG2854	intermembrane phospholipid transfer
vpachn25_RS13600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
vpachn25_RS13605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
vpachn25_RS13610	COG1127	ABC transporter
vpachn25_RS13620	COG0517	IMP dehydrogenase activity
vpachn25_RS13620	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
vpachn25_RS13630	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
vpachn25_RS13635	COG1137	ATPase activity
vpachn25_RS13645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
vpachn25_RS13650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
vpachn25_RS13655	COG1660	Displays ATPase and GTPase activities
vpachn25_RS13660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
vpachn25_RS13665	COG2239	Acts as a magnesium transporter
vpachn25_RS13670	COG0312	modulator of DNA gyrase
vpachn25_RS13675	COG3028	Belongs to the UPF0307 family
vpachn25_RS13680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
vpachn25_RS13685	COG0564	pseudouridine synthase activity
vpachn25_RS13695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
vpachn25_RS13700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
vpachn25_RS13705	COG0312	modulator of DNA gyrase
vpachn25_RS13710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
vpachn25_RS13715	COG3164	Protein of unknown function
vpachn25_RS13725	COG0424	maF-like protein
vpachn25_RS13730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
vpachn25_RS13735	COG1792	Involved in formation and maintenance of cell shape
vpachn25_RS13740	COG1077	Cell shape determining protein MreB Mrl
vpachn25_RS13775	COG2165	general secretion pathway protein
vpachn25_RS13785	COG1459	type II secretion system
vpachn25_RS13790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
vpachn25_RS13800	COG3267	Type II secretory pathway component ExeA
vpachn25_RS13800	COG3409	Peptidoglycan-binding domain 1 protein
vpachn25_RS13825	COG2200	EAL domain
vpachn25_RS13825	COG2199	diguanylate cyclase activity
vpachn25_RS13830	COG0629	single-stranded DNA binding
vpachn25_RS13845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
vpachn25_RS13855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
vpachn25_RS13865	COG0527	aspartate kinase activity
vpachn25_RS13870	COG0646	methionine synthase
vpachn25_RS13870	COG1410	methionine synthase
vpachn25_RS13920	COG0175	sulfate reduction
vpachn25_RS13925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
vpachn25_RS13930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
vpachn25_RS13950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
vpachn25_RS13955	COG0735	belongs to the Fur family
vpachn25_RS13965	COG0166	Belongs to the GPI family
vpachn25_RS13970	COG0432	Pfam Uncharacterised protein family UPF0047
vpachn25_RS13980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
vpachn25_RS13995	COG0359	binds to the 23S rRNA
vpachn25_RS14005	COG2965	DNA replication, synthesis of RNA primer
vpachn25_RS14010	COG0360	Binds together with S18 to 16S ribosomal RNA
vpachn25_RS14015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
vpachn25_RS14020	COG0338	D12 class N6 adenine-specific DNA methyltransferase
vpachn25_RS14030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
vpachn25_RS14035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
vpachn25_RS14065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
vpachn25_RS14075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
vpachn25_RS14075	COG0678	peroxiredoxin activity
vpachn25_RS14085	COG0165	Argininosuccinate lyase
vpachn25_RS14085	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
vpachn25_RS14090	COG0137	argininosuccinate synthase activity
vpachn25_RS14095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
vpachn25_RS14100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
vpachn25_RS14105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
vpachn25_RS14110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
vpachn25_RS14120	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
vpachn25_RS14125	COG0460	homoserine dehydrogenase
vpachn25_RS14125	COG0527	aspartate kinase activity
vpachn25_RS14130	COG0626	cystathionine gamma-synthase activity
vpachn25_RS14140	COG0281	malic enzyme
vpachn25_RS14150	COG2906	2 iron, 2 sulfur cluster binding
vpachn25_RS14155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
vpachn25_RS14160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
vpachn25_RS14165	COG0049	tRNA binding
vpachn25_RS14180	COG2923	Belongs to the DsrF TusC family
vpachn25_RS14185	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
vpachn25_RS14190	COG2964	Protein conserved in bacteria
vpachn25_RS14195	COG0545	Peptidyl-prolyl cis-trans isomerase
vpachn25_RS14205	COG2900	Belongs to the SlyX family
vpachn25_RS14210	COG1446	asparaginase
vpachn25_RS14215	COG1047	Peptidyl-prolyl cis-trans
vpachn25_RS14230	COG2249	NAD(P)H dehydrogenase (quinone) activity
vpachn25_RS14235	COG0488	(ABC) transporter
vpachn25_RS14245	COG0429	hydrolase of the alpha beta-hydrolase fold
vpachn25_RS14250	COG3089	Belongs to the UPF0270 family
vpachn25_RS14255	COG3954	Phosphoribulokinase
vpachn25_RS14260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
vpachn25_RS14270	COG1012	belongs to the aldehyde dehydrogenase family
vpachn25_RS14280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
vpachn25_RS14285	COG0512	Glutamine amidotransferase of anthranilate synthase
vpachn25_RS14300	COG0180	Tryptophanyl-tRNA synthetase
vpachn25_RS14305	COG0546	phosphoglycolate phosphatase activity
vpachn25_RS14310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
vpachn25_RS14315	COG0557	exoribonuclease II activity
vpachn25_RS14320	COG1959	2 iron, 2 sulfur cluster binding
vpachn25_RS14325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
vpachn25_RS14325	COG1017	nitric oxide dioxygenase activity
vpachn25_RS14330	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
vpachn25_RS14335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
vpachn25_RS14340	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
vpachn25_RS14345	COG0330	HflC and HflK could
vpachn25_RS14350	COG0330	HflC and HflK could
vpachn25_RS14355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
vpachn25_RS14365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
vpachn25_RS14370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
vpachn25_RS14375	COG0860	N-Acetylmuramoyl-L-alanine amidase
vpachn25_RS14380	COG0802	atpase or kinase
vpachn25_RS14385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
vpachn25_RS14455	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
vpachn25_RS14460	COG1162	GTPase activity
vpachn25_RS14465	COG0688	phosphatidylethanolamine metabolic process
vpachn25_RS14470	COG0471	metal ion transport
vpachn25_RS14475	COG0840	transmembrane signaling receptor activity
vpachn25_RS14485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
vpachn25_RS14490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
vpachn25_RS14495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
vpachn25_RS14500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
vpachn25_RS14505	COG1045	serine acetyltransferase
vpachn25_RS14510	COG4942	peptidase
vpachn25_RS14530	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
vpachn25_RS14535	COG1053	succinate dehydrogenase
vpachn25_RS14540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
vpachn25_RS14545	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
vpachn25_RS14550	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
vpachn25_RS14560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
vpachn25_RS14565	COG1509	lysine 2,3-aminomutase activity
vpachn25_RS14570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
vpachn25_RS14590	COG0459	protein refolding
vpachn25_RS14600	COG0534	Mate efflux family protein
vpachn25_RS14605	COG0205	6-phosphofructokinase activity
vpachn25_RS14615	COG3678	ATP-independent chaperone mediated protein folding
vpachn25_RS14620	COG0745	RESPONSE REGULATOR receiver
vpachn25_RS14625	COG2205	protein histidine kinase activity
vpachn25_RS14635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
vpachn25_RS14640	COG3030	protein affecting phage T7 exclusion by the F plasmid
vpachn25_RS14645	COG1027	Aspartate ammonia-lyase
vpachn25_RS14650	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
vpachn25_RS14655	COG4232	protein-disulfide reductase activity
vpachn25_RS14665	COG3263	regulation of cellular component size
vpachn25_RS14675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
vpachn25_RS14695	COG2205	protein histidine kinase activity
vpachn25_RS14695	COG2198	Histidine kinase
vpachn25_RS14695	COG0784	Response regulator, receiver
vpachn25_RS14700	COG2814	Major facilitator Superfamily
vpachn25_RS14715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
vpachn25_RS14720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
vpachn25_RS14725	COG0511	ligase activity, forming carbon-carbon bonds
vpachn25_RS14730	COG0439	Biotin carboxylase
vpachn25_RS14735	COG2264	protein methyltransferase activity
vpachn25_RS14740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
vpachn25_RS14745	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
vpachn25_RS14750	COG2814	Major facilitator Superfamily
vpachn25_RS14755	COG0488	(ABC) transporter
vpachn25_RS14760	COG3706	GGDEF domain
vpachn25_RS14795	COG1982	Orn Lys Arg decarboxylase major
vpachn25_RS14800	COG0531	amino acid
vpachn25_RS14805	COG3710	Transcriptional regulator
vpachn25_RS14810	COG0789	Transcriptional regulator
vpachn25_RS14815	COG0138	bifunctional purine biosynthesis protein purh
vpachn25_RS14820	COG0151	Belongs to the GarS family
vpachn25_RS14835	COG1253	flavin adenine dinucleotide binding
vpachn25_RS14845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
vpachn25_RS14850	COG1573	uracil-dna glycosylase
vpachn25_RS14855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
vpachn25_RS14870	COG2816	NAD+ diphosphatase activity
vpachn25_RS14875	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
vpachn25_RS14880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
vpachn25_RS14885	COG0085	RNA polymerase activity
vpachn25_RS14890	COG0222	ribosome binding
vpachn25_RS14895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
vpachn25_RS14900	COG0081	regulation of translation
vpachn25_RS14905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
vpachn25_RS14910	COG0250	Participates in transcription elongation, termination and antitermination
vpachn25_RS14915	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
vpachn25_RS14920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
vpachn25_RS14955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
vpachn25_RS14965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
vpachn25_RS15005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
vpachn25_RS15015	COG4206	TonB-dependent receptor
vpachn25_RS15020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
vpachn25_RS15035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
vpachn25_RS15040	COG0534	Mate efflux family protein
vpachn25_RS15045	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
vpachn25_RS15050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
vpachn25_RS15055	COG2937	Belongs to the GPAT DAPAT family
vpachn25_RS15060	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
vpachn25_RS15065	COG3161	chorismate lyase activity
vpachn25_RS15070	COG1580	Controls the rotational direction of flagella during chemotaxis
vpachn25_RS15075	COG0705	Rhomboid family
vpachn25_RS15080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
vpachn25_RS15090	COG2177	Part of the ABC transporter FtsEX involved in
vpachn25_RS15095	COG2884	Cell division ATP-binding protein ftsE
vpachn25_RS15100	COG0552	protein localization to endoplasmic reticulum
vpachn25_RS15105	COG0742	ribosomal rna small subunit methyltransferase
vpachn25_RS15115	COG2095	MarC family integral membrane protein
vpachn25_RS15165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
vpachn25_RS15170	COG0640	Transcriptional regulator
vpachn25_RS15175	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
vpachn25_RS15180	COG1280	lysine exporter protein (LysE YggA)
vpachn25_RS15185	COG2267	carboxylic ester hydrolase activity
vpachn25_RS15190	COG0561	phosphatase activity
vpachn25_RS15205	COG3148	PFAM DTW domain containing protein
vpachn25_RS15210	COG2199	diguanylate cyclase activity
vpachn25_RS15210	COG2200	EAL domain
vpachn25_RS15210	COG3287	FIST C domain
vpachn25_RS15215	COG1011	Hydrolase
vpachn25_RS15220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
vpachn25_RS15230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
vpachn25_RS15235	COG0019	diaminopimelate decarboxylase activity
vpachn25_RS15245	COG1965	Belongs to the frataxin family
vpachn25_RS15250	COG3072	Adenylate cyclase
vpachn25_RS15255	COG0181	hydroxymethylbilane synthase activity
vpachn25_RS15260	COG1587	Uroporphyrinogen-III synthase
vpachn25_RS15265	COG2959	enzyme of heme biosynthesis
vpachn25_RS15270	COG3071	HemY protein
vpachn25_RS15325	COG0633	Ferredoxin
vpachn25_RS15330	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
vpachn25_RS15345	COG3118	belongs to the thioredoxin family
vpachn25_RS15350	COG0513	Belongs to the DEAD box helicase family
vpachn25_RS15355	COG0248	Ppx GppA phosphatase
vpachn25_RS15360	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
vpachn25_RS15370	COG0514	ATP-dependent DNA helicase (RecQ)
vpachn25_RS15375	COG2962	Rard protein
vpachn25_RS15385	COG1280	lysine exporter protein (LysE YggA)
vpachn25_RS15390	COG0405	Gamma-glutamyltransferase
vpachn25_RS15395	COG0210	DNA helicase
vpachn25_RS15405	COG3220	belongs to the UPF0276 family
vpachn25_RS15435	COG0006	proline dipeptidase activity
vpachn25_RS15435	COG0006	proline dipeptidase activity
vpachn25_RS15445	COG2022	thiamine diphosphate biosynthetic process
vpachn25_RS15450	COG2104	thiamine diphosphate biosynthetic process
vpachn25_RS15455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
vpachn25_RS15465	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
vpachn25_RS15470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
vpachn25_RS15515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
vpachn25_RS15525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
vpachn25_RS15530	COG0408	coproporphyrinogen oxidase activity
vpachn25_RS15535	COG0009	L-threonylcarbamoyladenylate synthase
vpachn25_RS15540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
vpachn25_RS15545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
vpachn25_RS15550	COG0551	DNA topoisomerase type I activity
vpachn25_RS15555	COG2922	Belongs to the Smg family
vpachn25_RS15560	COG0758	DNA mediated transformation
vpachn25_RS15570	COG0242	peptide deformylase activity
vpachn25_RS15575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
vpachn25_RS15580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
vpachn25_RS15580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
vpachn25_RS15585	COG0569	domain protein
vpachn25_RS15590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
vpachn25_RS15600	COG1272	protein, Hemolysin III
vpachn25_RS15605	COG4326	sporulation control protein
vpachn25_RS15610	COG3084	Protein conserved in bacteria
vpachn25_RS15620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
vpachn25_RS15625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
vpachn25_RS15630	COG0204	Acyl-transferase
vpachn25_RS15640	COG0606	chelatase, subunit chli
vpachn25_RS15650	COG3978	acetolactate synthase activity
vpachn25_RS15655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
vpachn25_RS15660	COG0129	dihydroxy-acid dehydratase activity
vpachn25_RS15670	COG0583	DNA-binding transcription factor activity
vpachn25_RS15675	COG2814	Major facilitator Superfamily
vpachn25_RS15680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vpachn25_RS15685	COG0765	amino acid transport
vpachn25_RS15690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
vpachn25_RS15695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
vpachn25_RS15700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
vpachn25_RS15705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
vpachn25_RS15710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
vpachn25_RS15715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
vpachn25_RS15730	COG0356	it plays a direct role in the translocation of protons across the membrane
vpachn25_RS15735	COG3312	ion transport
vpachn25_RS15740	COG1475	DNA binding
vpachn25_RS15745	COG1192	Involved in chromosome partitioning
vpachn25_RS15750	COG0357	Ribosomal RNA small subunit methyltransferase G
vpachn25_RS15755	COG0445	tRNA wobble uridine modification
vpachn25_RS15760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
vpachn25_RS15765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
vpachn25_RS15770	COG0706	membrane insertase activity
vpachn25_RS15775	COG0594	ribonuclease P activity
vpachn25_RS15785	COG1126	abc transporter atp-binding protein
vpachn25_RS15990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vpachn25_RS16325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vpachn25_RS16325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vpachn25_RS16330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vpachn25_RS16330	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vpachn25_RS16405	COG0174	glutamine synthetase
vpachn25_RS16505	COG1459	type II secretion system
vpachn25_RS16920	COG1560	Kdo2-lipid A biosynthetic process
vpachn25_RS17435	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
vpachn25_RS17530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
vpachn25_RS17610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
vpachn25_RS17665	COG0246	Mannitol dehydrogenase
vpachn25_RS17730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
vpachn25_RS17990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
vpachn25_RS18030	COG0653	protein targeting
vpachn25_RS18060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
vpachn25_RS18115	COG0067	glutamate synthase
vpachn25_RS18115	COG0070	glutamate synthase
vpachn25_RS18115	COG0069	glutamate synthase activity
vpachn25_RS18160	COG0067	glutamate synthase
vpachn25_RS18160	COG0069	glutamate synthase activity
vpachn25_RS18160	COG0070	glutamate synthase
vpachn25_RS18390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
vpachn25_RS18495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vpachn25_RS18515	COG0542	response to heat
vpachn25_RS18815	COG1584	GPR1 FUN34 yaaH family protein
vpachn25_RS18990	COG0443	Heat shock 70 kDa protein
vpachn25_RS19070	COG1073	alpha beta
vpachn25_RS19090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
vpachn25_RS19445	COG0737	Belongs to the 5'-nucleotidase family
vpachn25_RS19535	COG4386	tail sheath protein
vpachn25_RS19810	COG2194	sulfuric ester hydrolase activity
vpachn25_RS19985	COG1263	PTS System
vpachn25_RS19985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vpachn25_RS20405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
vpachn25_RS20480	COG0318	PFAM AMP-dependent synthetase and ligase
vpachn25_RS21555	COG1674	ftsk spoiiie
vpachn25_RS21605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
vpachn25_RS21760	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vpachn25_RS22215	COG3048	D-serine ammonia-lyase activity
vpachn25_RS22340	COG0247	lactate metabolic process
vpachn25_RS22340	COG0277	FAD linked oxidase domain protein
vpachn25_RS22545	COG1176	ABC-type spermidine putrescine transport system, permease component I
vpachn25_RS23065	COG0243	molybdopterin cofactor binding
vpachn25_RS23865	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
vpachn25_RS23885	COG0187	DNA topoisomerase II activity
vpachn25_RS23905	COG0366	Alpha amylase catalytic
vpachn25_RS23915	COG0751	glycine-tRNA ligase activity
vpachn25_RS23950	COG0183	Belongs to the thiolase family
vpachn25_RS23960	COG1250	3-hydroxyacyl-CoA dehydrogenase
vpachn25_RS23960	COG1024	Enoyl-CoA hydratase
vpachn25_RS24045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vpachn25_RS24060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vpachn25_RS24235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
vpachn25_RS24250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
vpachn25_RS24435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
vpachn25_RS24470	COG0187	DNA topoisomerase II activity
vpachn25_RS24665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vpachn25_RS24785	COG0339	signal peptide processing
vpachn25_RS24825	COG2081	HI0933 family
vpachn25_RS24860	COG0187	DNA topoisomerase II activity