locus-tag	class	description
A6J30_RS00015	COG3063	Type IV pilus biogenesis stability protein PilW
A6J30_RS00020	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A6J30_RS00035	COG0531	amino acid
A6J30_RS00045	COG1560	Kdo2-lipid A biosynthetic process
A6J30_RS00050	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6J30_RS00055	COG1280	lysine exporter protein (LysE YggA)
A6J30_RS00065	COG1115	amino acid carrier protein
A6J30_RS00090	COG1368	sulfuric ester hydrolase activity
A6J30_RS00095	COG0642	Histidine kinase
A6J30_RS00100	COG0745	RESPONSE REGULATOR receiver
A6J30_RS00110	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS00130	COG2113	Glycine betaine
A6J30_RS00135	COG4176	ABC-type proline glycine betaine transport system permease component
A6J30_RS00155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J30_RS00160	COG0456	acetyltransferase
A6J30_RS00165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6J30_RS00170	COG0662	Cupin 2, conserved barrel domain protein
A6J30_RS00175	COG0527	aspartate kinase activity
A6J30_RS00180	COG1858	cytochrome C peroxidase
A6J30_RS00195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J30_RS00210	COG3290	protein histidine kinase activity
A6J30_RS00215	COG4565	transcriptional regulatory protein
A6J30_RS00220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6J30_RS00225	COG0363	glucosamine-6-phosphate deaminase activity
A6J30_RS00230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6J30_RS00255	COG3284	Transcriptional regulator
A6J30_RS00260	COG1012	belongs to the aldehyde dehydrogenase family
A6J30_RS00330	COG4669	(LipO)protein
A6J30_RS00350	COG3177	Filamentation induced by cAMP protein fic
A6J30_RS00390	COG1073	alpha beta
A6J30_RS00395	COG1073	alpha beta
A6J30_RS00405	COG4792	protein secretion
A6J30_RS00410	COG4791	protein targeting
A6J30_RS00415	COG4794	Type iii secretion
A6J30_RS00420	COG4790	Type iii secretion
A6J30_RS00490	COG0457	Tetratricopeptide repeat
A6J30_RS00510	COG0730	response to heat
A6J30_RS00540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6J30_RS00545	COG0372	Belongs to the citrate synthase family
A6J30_RS00555	COG2828	Protein conserved in bacteria
A6J30_RS00580	COG0561	phosphatase activity
A6J30_RS00585	COG0602	queuosine metabolic process
A6J30_RS00590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6J30_RS00595	COG3706	GGDEF domain
A6J30_RS00635	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J30_RS00640	COG0840	transmembrane signaling receptor activity
A6J30_RS00645	COG1254	Belongs to the acylphosphatase family
A6J30_RS00650	COG2920	part of a sulfur-relay system
A6J30_RS00660	COG0670	Belongs to the BI1 family
A6J30_RS00665	COG1126	abc transporter atp-binding protein
A6J30_RS00670	COG0765	amino acid transport
A6J30_RS00675	COG4597	amino acid ABC transporter
A6J30_RS00680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J30_RS00700	COG1666	GTP binding
A6J30_RS00705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J30_RS00725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J30_RS00725	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A6J30_RS00735	COG3008	intermembrane lipid transfer
A6J30_RS00740	COG2995	paraquat-inducible protein a
A6J30_RS00745	COG1132	(ABC) transporter
A6J30_RS00750	COG1956	GAF domain-containing protein
A6J30_RS00755	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A6J30_RS00770	COG0308	aminopeptidase N
A6J30_RS00780	COG2902	Dehydrogenase
A6J30_RS00785	COG0167	dihydroorotate dehydrogenase activity
A6J30_RS00800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J30_RS00800	COG0116	Belongs to the methyltransferase superfamily
A6J30_RS00810	COG0488	(ABC) transporter
A6J30_RS00825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J30_RS00830	COG1067	ATP-dependent peptidase activity
A6J30_RS00835	COG3120	sequence-specific DNA binding
A6J30_RS01045	COG2205	protein histidine kinase activity
A6J30_RS01045	COG0784	Response regulator, receiver
A6J30_RS01060	COG3278	Belongs to the heme-copper respiratory oxidase family
A6J30_RS01075	COG2010	Cytochrome c
A6J30_RS01085	COG2217	Heavy metal translocating P-type atpase
A6J30_RS01100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J30_RS01105	COG0589	response to stress
A6J30_RS01115	COG0037	tRNA processing
A6J30_RS01135	COG3842	ATPase activity
A6J30_RS01145	COG1177	transmembrane transport
A6J30_RS01155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6J30_RS01160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6J30_RS01170	COG0004	ammonium transporteR
A6J30_RS01215	COG0437	4 iron, 4 sulfur cluster binding
A6J30_RS01220	COG0243	molybdopterin cofactor binding
A6J30_RS01220	COG3383	formate dehydrogenase (NAD+) activity
A6J30_RS01255	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6J30_RS01260	COG0488	(ABC) transporter
A6J30_RS01270	COG4191	Histidine kinase
A6J30_RS01275	COG2204	response regulator
A6J30_RS01295	COG3842	ATPase activity
A6J30_RS01300	COG0746	molybdenum cofactor guanylyltransferase activity
A6J30_RS01305	COG0303	'Molybdopterin
A6J30_RS01315	COG1940	carbohydrate kinase activity
A6J30_RS01320	COG3148	PFAM DTW domain containing protein
A6J30_RS01355	COG0840	transmembrane signaling receptor activity
A6J30_RS01355	COG3290	protein histidine kinase activity
A6J30_RS01360	COG0791	NLP P60 protein
A6J30_RS01370	COG3706	GGDEF domain
A6J30_RS01375	COG2201	protein-glutamate methylesterase activity
A6J30_RS01380	COG3001	Fructosamine kinase
A6J30_RS01390	COG0307	riboflavin synthase, alpha
A6J30_RS01395	COG0534	Mate efflux family protein
A6J30_RS01405	COG1793	dna ligase
A6J30_RS01440	COG2204	response regulator
A6J30_RS01450	COG0438	transferase activity, transferring glycosyl groups
A6J30_RS01485	COG0438	transferase activity, transferring glycosyl groups
A6J30_RS01490	COG1215	transferase activity, transferring glycosyl groups
A6J30_RS01495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J30_RS01505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J30_RS01520	COG1643	Atp-dependent helicase
A6J30_RS01525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6J30_RS01540	COG3302	dmso reductase anchor subunit
A6J30_RS01545	COG0437	4 iron, 4 sulfur cluster binding
A6J30_RS01550	COG0243	molybdopterin cofactor binding
A6J30_RS01580	COG3706	GGDEF domain
A6J30_RS01590	COG0443	Heat shock 70 kDa protein
A6J30_RS01595	COG0443	Heat shock 70 kDa protein
A6J30_RS01625	COG1132	(ABC) transporter
A6J30_RS01630	COG1132	(ABC) transporter
A6J30_RS01655	COG0814	amino acid
A6J30_RS01670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6J30_RS01750	COG1522	sequence-specific DNA binding
A6J30_RS01785	COG0515	serine threonine protein kinase
A6J30_RS01810	COG3501	Rhs element vgr protein
A6J30_RS01825	COG2204	response regulator
A6J30_RS01850	COG0739	heme binding
A6J30_RS01860	COG0861	Integral membrane protein TerC family
A6J30_RS01870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J30_RS01875	COG1328	CTP reductase activity
A6J30_RS01880	COG1280	lysine exporter protein (LysE YggA)
A6J30_RS01890	COG3300	MHYT domain
A6J30_RS01890	COG5001	Diguanylate cyclase
A6J30_RS01900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J30_RS01900	COG4191	Histidine kinase
A6J30_RS01905	COG0471	metal ion transport
A6J30_RS01940	COG0583	DNA-binding transcription factor activity
A6J30_RS01945	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A6J30_RS01950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J30_RS01955	COG3264	Mechanosensitive ion channel
A6J30_RS01955	COG1511	domain protein
A6J30_RS01970	COG1127	ABC transporter
A6J30_RS01975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J30_RS02035	COG0625	glutathione transferase activity
A6J30_RS02045	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6J30_RS02060	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J30_RS02070	COG0601	transmembrane transport
A6J30_RS02075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J30_RS02080	COG0444	Belongs to the ABC transporter superfamily
A6J30_RS02100	COG3291	Pkd domain containing protein
A6J30_RS02115	COG1177	transmembrane transport
A6J30_RS02120	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6J30_RS02125	COG3842	ATPase activity
A6J30_RS02130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J30_RS02135	COG2423	ornithine cyclodeaminase activity
A6J30_RS02155	COG3938	Belongs to the proline racemase family
A6J30_RS02185	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A6J30_RS02190	COG1451	nucleotide metabolic process
A6J30_RS02195	COG3475	LICD family
A6J30_RS02200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J30_RS02205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6J30_RS02225	COG0583	DNA-binding transcription factor activity
A6J30_RS02245	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
A6J30_RS02250	COG4139	cobalamin transport
A6J30_RS02255	COG2988	succinylglutamate desuccinylase activity
A6J30_RS02280	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A6J30_RS02285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A6J30_RS02290	COG0702	epimerase
A6J30_RS02295	COG1823	symporter activity
A6J30_RS02300	COG2925	Exonuclease
A6J30_RS02305	COG1380	Effector of murein hydrolase LrgA
A6J30_RS02310	COG1346	cytolysis
A6J30_RS02315	COG0295	cytidine deaminase activity
A6J30_RS02320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6J30_RS02325	COG0500	methyltransferase
A6J30_RS02335	COG0776	regulation of translation
A6J30_RS02350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J30_RS02350	COG0072	phenylalanine-tRNA ligase activity
A6J30_RS02355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6J30_RS02360	COG3706	GGDEF domain
A6J30_RS02390	COG0393	Putative heavy-metal-binding
A6J30_RS02400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6J30_RS02410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6J30_RS02425	COG2188	Transcriptional regulator
A6J30_RS02430	COG1228	amidohydrolase
A6J30_RS02435	COG0010	Belongs to the arginase family
A6J30_RS02440	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A6J30_RS02445	COG2986	histidine ammonia-lyase
A6J30_RS02460	COG0277	FAD linked oxidase domain protein
A6J30_RS02460	COG0247	lactate metabolic process
A6J30_RS02495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6J30_RS02510	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A6J30_RS02515	COG1643	Atp-dependent helicase
A6J30_RS02520	COG0281	malic enzyme
A6J30_RS02525	COG2949	membrane
A6J30_RS02530	COG0471	metal ion transport
A6J30_RS02555	COG0492	ferredoxin-NADP+ reductase activity
A6J30_RS02560	COG4988	ABC transporter
A6J30_RS02565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6J30_RS02570	COG3048	D-serine ammonia-lyase activity
A6J30_RS02575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6J30_RS02585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J30_RS02585	COG4191	Histidine kinase
A6J30_RS02600	COG3070	regulator of competence-specific genes
A6J30_RS02620	COG2431	L-lysine efflux transmembrane transporter activity
A6J30_RS02630	COG0076	glutamate decarboxylase activity
A6J30_RS02635	COG1737	Transcriptional regulator
A6J30_RS02650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J30_RS02655	COG3273	potassium ion transport
A6J30_RS02655	COG2985	domain, Protein
A6J30_RS02660	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6J30_RS02675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J30_RS02690	COG4181	ATPase activity
A6J30_RS02695	COG0534	Mate efflux family protein
A6J30_RS02700	COG0702	epimerase
A6J30_RS02705	COG3005	denitrification pathway
A6J30_RS02735	COG2814	Major facilitator Superfamily
A6J30_RS02740	COG1187	pseudouridine synthase activity
A6J30_RS02745	COG1061	Type III restriction enzyme res subunit
A6J30_RS02765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6J30_RS02795	COG3313	Fe-S protein
A6J30_RS02820	COG0493	'glutamate synthase
A6J30_RS02830	COG0398	Pfam SNARE associated Golgi protein
A6J30_RS02835	COG4134	Bacterial extracellular solute-binding protein
A6J30_RS02840	COG4135	transport system, permease component
A6J30_RS02845	COG4136	ATPase activity
A6J30_RS02850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J30_RS02865	COG3604	Transcriptional regulator
A6J30_RS02870	COG1151	hydroxylamine reductase activity
A6J30_RS02875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J30_RS02885	COG0564	pseudouridine synthase activity
A6J30_RS02895	COG0733	neurotransmitter:sodium symporter activity
A6J30_RS02905	COG0626	cystathionine gamma-synthase activity
A6J30_RS02910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A6J30_RS02915	COG5380	lipid catabolic process
A6J30_RS02920	COG2818	Glycosylase
A6J30_RS02935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J30_RS02940	COG1983	PspC domain protein
A6J30_RS02950	COG1842	Phage shock protein A
A6J30_RS02955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6J30_RS02970	COG4171	peptide transport system, permease
A6J30_RS02980	COG4172	Belongs to the ABC transporter superfamily
A6J30_RS02990	COG1227	inorganic diphosphatase activity
A6J30_RS03005	COG0243	molybdopterin cofactor binding
A6J30_RS03010	COG3005	denitrification pathway
A6J30_RS03015	COG4459	periplasmic nitrate reductase
A6J30_RS03020	COG0390	transport system, permease component
A6J30_RS03030	COG2116	formate transmembrane transporter activity
A6J30_RS03055	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6J30_RS03060	COG1435	thymidine kinase activity
A6J30_RS03065	COG0215	cysteine-tRNA ligase activity
A6J30_RS03070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J30_RS03075	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J30_RS03080	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6J30_RS03090	COG3012	SEC-C Motif Domain Protein
A6J30_RS03095	COG0140	phosphoribosyl-ATP diphosphatase activity
A6J30_RS03095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6J30_RS03100	COG0107	imidazoleglycerol-phosphate synthase activity
A6J30_RS03105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6J30_RS03110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6J30_RS03115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J30_RS03115	COG0131	Imidazoleglycerol-phosphate dehydratase
A6J30_RS03120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6J30_RS03125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6J30_RS03130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6J30_RS03145	COG1757	Na H antiporter
A6J30_RS03155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J30_RS03165	COG0482	sulfurtransferase activity
A6J30_RS03170	COG2915	High frequency lysogenization protein hflD homolog
A6J30_RS03175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J30_RS03200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6J30_RS03215	COG0300	oxidoreductase activity
A6J30_RS03225	COG0501	Belongs to the peptidase M48B family
A6J30_RS03235	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6J30_RS03245	COG0156	8-amino-7-oxononanoate synthase activity
A6J30_RS03250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J30_RS03260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6J30_RS03275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6J30_RS03280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J30_RS03285	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6J30_RS03290	COG1674	ftsk spoiiie
A6J30_RS03300	COG0686	Belongs to the AlaDH PNT family
A6J30_RS03310	COG0583	DNA-binding transcription factor activity
A6J30_RS03325	COG3568	Endonuclease Exonuclease Phosphatase
A6J30_RS03355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J30_RS03360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J30_RS03375	COG0840	transmembrane signaling receptor activity
A6J30_RS03390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6J30_RS03435	COG0582	viral genome integration into host DNA
A6J30_RS03485	COG0784	Response regulator, receiver
A6J30_RS03485	COG5002	protein histidine kinase activity
A6J30_RS03495	COG0754	glutathionylspermidine amidase activity
A6J30_RS03505	COG3766	membrane
A6J30_RS03515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6J30_RS03520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6J30_RS03525	COG2885	chlorophyll binding
A6J30_RS03530	COG0823	Involved in the tonB-independent uptake of proteins
A6J30_RS03545	COG0811	peptide transport
A6J30_RS03550	COG0824	Thioesterase
A6J30_RS03560	COG4890	Cyd operon protein YbgT
A6J30_RS03565	COG1294	oxidase, subunit
A6J30_RS03570	COG1271	oxidase subunit
A6J30_RS03575	COG2255	four-way junction helicase activity
A6J30_RS03580	COG0632	four-way junction helicase activity
A6J30_RS03585	COG0840	transmembrane signaling receptor activity
A6J30_RS03590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6J30_RS03595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6J30_RS03600	COG1801	Protein of unknown function DUF72
A6J30_RS03605	COG4106	trans-aconitate 2-methyltransferase activity
A6J30_RS03610	COG0500	methyltransferase
A6J30_RS03620	COG0189	ligase activity
A6J30_RS03620	COG4067	protein conserved in archaea
A6J30_RS03640	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6J30_RS03645	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A6J30_RS03650	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A6J30_RS03655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J30_RS03660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6J30_RS03665	COG0745	RESPONSE REGULATOR receiver
A6J30_RS03670	COG3381	protein complex oligomerization
A6J30_RS03675	COG1609	Transcriptional regulator
A6J30_RS03680	COG3070	regulator of competence-specific genes
A6J30_RS03700	COG0297	glycogen (starch) synthase activity
A6J30_RS03705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J30_RS03710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J30_RS03720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6J30_RS03730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6J30_RS03735	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6J30_RS03740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6J30_RS03750	COG0542	response to heat
A6J30_RS03755	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6J30_RS03760	COG1278	Cold shock
A6J30_RS03770	COG1187	pseudouridine synthase activity
A6J30_RS03775	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A6J30_RS03785	COG1199	ATP-dependent helicase activity
A6J30_RS03790	COG0730	response to heat
A6J30_RS03795	COG3923	Primosomal replication protein n
A6J30_RS03805	COG0708	Exodeoxyribonuclease III
A6J30_RS03850	COG1882	Formate acetyltransferase
A6J30_RS03860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J30_RS03870	COG3013	Belongs to the UPF0304 family
A6J30_RS03880	COG2766	serine protein kinase
A6J30_RS03885	COG2718	Belongs to the UPF0229 family
A6J30_RS03890	COG2719	SpoVR family
A6J30_RS03895	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6J30_RS03905	COG1663	tetraacyldisaccharide 4'-kinase activity
A6J30_RS03910	COG1132	(ABC) transporter
A6J30_RS03915	COG2333	competence protein COMEC
A6J30_RS03915	COG0658	competence protein
A6J30_RS03925	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6J30_RS03930	COG1136	(ABC) transporter
A6J30_RS03935	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6J30_RS03945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J30_RS03965	COG1252	NADH dehydrogenase
A6J30_RS03975	COG3150	esterase
A6J30_RS04000	COG0537	adenosine 5'-monophosphoramidase activity
A6J30_RS04030	COG0517	IMP dehydrogenase activity
A6J30_RS04030	COG0516	GMP reductase activity
A6J30_RS04040	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6J30_RS04045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6J30_RS04050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J30_RS04060	COG2199	diguanylate cyclase activity
A6J30_RS04075	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A6J30_RS04080	COG1946	Acyl-CoA thioesterase
A6J30_RS04090	COG1522	sequence-specific DNA binding
A6J30_RS04120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J30_RS04170	COG0477	Major facilitator Superfamily
A6J30_RS04175	COG2855	membrane
A6J30_RS04195	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6J30_RS04200	COG0596	Alpha beta hydrolase
A6J30_RS04205	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6J30_RS04210	COG1169	isochorismate synthase
A6J30_RS04215	COG0436	Aminotransferase
A6J30_RS04220	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6J30_RS04225	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6J30_RS04240	COG1555	photosystem II stabilization
A6J30_RS04245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J30_RS04250	COG0776	regulation of translation
A6J30_RS04255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6J30_RS04260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6J30_RS04270	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6J30_RS04280	COG2204	response regulator
A6J30_RS04290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6J30_RS04295	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6J30_RS04300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6J30_RS04305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6J30_RS04325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J30_RS04330	COG0569	domain protein
A6J30_RS04335	COG0513	Belongs to the DEAD box helicase family
A6J30_RS04340	COG1253	flavin adenine dinucleotide binding
A6J30_RS04375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J30_RS04380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J30_RS04395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J30_RS04400	COG1216	Glycosyl transferase, family 2
A6J30_RS04405	COG2986	histidine ammonia-lyase
A6J30_RS04430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J30_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS04445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J30_RS04460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6J30_RS04465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J30_RS04470	COG0583	DNA-binding transcription factor activity
A6J30_RS04475	COG2951	lytic endotransglycosylase activity
A6J30_RS04480	COG3100	YcgL domain-containing protein
A6J30_RS04485	COG0850	regulation of cytokinetic process
A6J30_RS04490	COG2894	cell division
A6J30_RS04495	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A6J30_RS04500	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6J30_RS04505	COG0318	PFAM AMP-dependent synthetase and ligase
A6J30_RS04510	COG2267	carboxylic ester hydrolase activity
A6J30_RS04525	COG1214	PFAM Peptidase M22, glycoprotease
A6J30_RS04530	COG1199	ATP-dependent helicase activity
A6J30_RS04535	COG0788	formyltetrahydrofolate deformylase activity
A6J30_RS04540	COG3102	Protein conserved in bacteria
A6J30_RS04550	COG0018	arginyl-trna synthetase
A6J30_RS04570	COG1918	ferrous iron import across plasma membrane
A6J30_RS04585	COG4977	sequence-specific DNA binding
A6J30_RS04590	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6J30_RS04595	COG1121	(ABC) transporter
A6J30_RS04600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J30_RS04610	COG0045	succinate-CoA ligase (ADP-forming) activity
A6J30_RS04615	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J30_RS04620	COG0567	Dehydrogenase, E1 component
A6J30_RS04625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J30_RS04630	COG1053	succinate dehydrogenase
A6J30_RS04635	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6J30_RS04650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6J30_RS04660	COG0033	Phosphoglucomutase
A6J30_RS04665	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6J30_RS04670	COG0596	Alpha beta hydrolase
A6J30_RS04690	COG0735	belongs to the Fur family
A6J30_RS04695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J30_RS04700	COG1263	PTS System
A6J30_RS04700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J30_RS04710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6J30_RS04715	COG1846	Transcriptional regulator
A6J30_RS04715	COG1940	carbohydrate kinase activity
A6J30_RS04720	COG4651	solute:proton antiporter activity
A6J30_RS04720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6J30_RS04725	COG0367	asparagine synthase
A6J30_RS04730	COG0250	Participates in transcription elongation, termination and antitermination
A6J30_RS04735	COG3104	oligopeptide transport
A6J30_RS04740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6J30_RS04745	COG0563	adenylate kinase activity
A6J30_RS04750	COG0326	Molecular chaperone. Has ATPase activity
A6J30_RS04755	COG3710	Transcriptional regulator
A6J30_RS04775	COG0622	Phosphoesterase
A6J30_RS04805	COG1090	epimerase
A6J30_RS04810	COG0300	oxidoreductase activity
A6J30_RS04820	COG3118	belongs to the thioredoxin family
A6J30_RS04825	COG0330	HflC and HflK could
A6J30_RS04855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J30_RS04860	COG3115	cell septum assembly
A6J30_RS04865	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A6J30_RS04870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6J30_RS04880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J30_RS04885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J30_RS04890	COG2190	(PTS) system
A6J30_RS04900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J30_RS04905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J30_RS04915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J30_RS04925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J30_RS04935	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6J30_RS04935	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J30_RS04940	COG1706	bacterial-type flagellum-dependent cell motility
A6J30_RS04945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6J30_RS04955	COG4787	bacterial-type flagellum-dependent cell motility
A6J30_RS04965	COG1749	Flagellar hook protein flgE
A6J30_RS04975	COG1558	bacterial-type flagellum-dependent cell motility
A6J30_RS04980	COG1815	bacterial-type flagellum-dependent cell motility
A6J30_RS04985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6J30_RS04990	COG0784	Response regulator, receiver
A6J30_RS04990	COG0835	chemotaxis
A6J30_RS05050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J30_RS05055	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A6J30_RS05070	COG2608	mercury ion transmembrane transporter activity
A6J30_RS05070	COG2217	Heavy metal translocating P-type atpase
A6J30_RS05110	COG2840	Smr protein MutS2
A6J30_RS05115	COG1187	pseudouridine synthase activity
A6J30_RS05125	COG0737	Belongs to the 5'-nucleotidase family
A6J30_RS05130	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6J30_RS05135	COG2912	Transglutaminase-like superfamily
A6J30_RS05140	COG3094	Invasion gene expression up-regulator, SirB
A6J30_RS05145	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J30_RS05150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J30_RS05155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6J30_RS05160	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6J30_RS05165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6J30_RS05170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6J30_RS05175	COG0193	aminoacyl-tRNA hydrolase activity
A6J30_RS05180	COG0012	GTP binding
A6J30_RS05295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J30_RS05305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J30_RS05310	COG1702	phosphate starvation-inducible protein PhoH
A6J30_RS05315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6J30_RS05320	COG4535	Mg2 and Co2 transporter CorC
A6J30_RS05325	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6J30_RS05330	COG2888	peptidyl-tyrosine sulfation
A6J30_RS05335	COG0495	leucyl-tRNA aminoacylation
A6J30_RS05340	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6J30_RS05345	COG1466	dna polymerase III delta subunit
A6J30_RS05350	COG0799	negative regulation of ribosome biogenesis
A6J30_RS05355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6J30_RS05360	COG0768	penicillin binding
A6J30_RS05365	COG0772	Belongs to the SEDS family
A6J30_RS05370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6J30_RS05375	COG1686	Belongs to the peptidase S11 family
A6J30_RS05380	COG2921	Belongs to the UPF0250 family
A6J30_RS05385	COG0321	lipoyl(octanoyl) transferase activity
A6J30_RS05390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6J30_RS05395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6J30_RS05400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J30_RS05415	COG0366	Alpha amylase catalytic
A6J30_RS05420	COG1263	PTS System
A6J30_RS05420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J30_RS05430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J30_RS05440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J30_RS05445	COG2011	ABC-type metal ion transport system permease component
A6J30_RS05450	COG1464	Belongs to the NlpA lipoprotein family
A6J30_RS05455	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A6J30_RS05465	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6J30_RS05465	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6J30_RS05480	COG1611	Belongs to the LOG family
A6J30_RS05485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J30_RS05495	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A6J30_RS05500	COG2363	Small membrane protein
A6J30_RS05510	COG0583	DNA-binding transcription factor activity
A6J30_RS05515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J30_RS05515	COG0301	tRNA thio-modification
A6J30_RS05525	COG2885	chlorophyll binding
A6J30_RS05530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6J30_RS05535	COG1722	exodeoxyribonuclease VII activity
A6J30_RS05540	COG0142	geranyltranstransferase activity
A6J30_RS05545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6J30_RS05550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6J30_RS05555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6J30_RS05560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J30_RS05580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J30_RS05580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J30_RS05585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6J30_RS05590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6J30_RS05595	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6J30_RS05605	COG1073	alpha beta
A6J30_RS05610	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A6J30_RS05615	COG2252	PERMEase
A6J30_RS05620	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J30_RS05645	COG0047	phosphoribosylformylglycinamidine synthase activity
A6J30_RS05645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J30_RS05650	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6J30_RS05665	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6J30_RS05705	COG0484	heat shock protein binding
A6J30_RS05710	COG0443	Heat shock 70 kDa protein
A6J30_RS05720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6J30_RS05725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6J30_RS05735	COG0497	DNA recombination
A6J30_RS05740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J30_RS05745	COG2914	Belongs to the UPF0125 (RnfH) family
A6J30_RS05750	COG2867	negative regulation of translational initiation
A6J30_RS05755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6J30_RS05770	COG0328	RNA-DNA hybrid ribonuclease activity
A6J30_RS05810	COG0583	DNA-binding transcription factor activity
A6J30_RS05815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J30_RS05815	COG3153	acetyltransferase
A6J30_RS05835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J30_RS05840	COG2873	o-acetylhomoserine
A6J30_RS05875	COG1115	amino acid carrier protein
A6J30_RS05885	COG1584	GPR1 FUN34 yaaH family protein
A6J30_RS05895	COG1757	Na H antiporter
A6J30_RS05900	COG0519	Catalyzes the synthesis of GMP from XMP
A6J30_RS05900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6J30_RS05905	COG0516	GMP reductase activity
A6J30_RS05905	COG0517	IMP dehydrogenase activity
A6J30_RS05910	COG1570	exodeoxyribonuclease VII activity
A6J30_RS05925	COG1160	GTP binding
A6J30_RS05930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J30_RS05935	COG2976	Protein conserved in bacteria
A6J30_RS05940	COG0124	histidyl-tRNA synthetase
A6J30_RS05945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6J30_RS05960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6J30_RS05965	COG0105	UTP biosynthetic process
A6J30_RS05970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6J30_RS05975	COG2975	iron-sulfur cluster assembly
A6J30_RS05980	COG0633	Ferredoxin
A6J30_RS05985	COG0443	Heat shock 70 kDa protein
A6J30_RS05990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6J30_RS06000	COG0822	iron-sulfur transferase activity
A6J30_RS06005	COG1104	cysteine desulfurase activity
A6J30_RS06010	COG1959	2 iron, 2 sulfur cluster binding
A6J30_RS06020	COG0483	inositol monophosphate 1-phosphatase activity
A6J30_RS06030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J30_RS06035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J30_RS06040	COG1862	Preprotein translocase
A6J30_RS06045	COG0343	queuine tRNA-ribosyltransferase activity
A6J30_RS06050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6J30_RS06065	COG0517	IMP dehydrogenase activity
A6J30_RS06075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6J30_RS06085	COG0583	DNA-binding transcription factor activity
A6J30_RS06090	COG0450	alkyl hydroperoxide reductase
A6J30_RS06100	COG3142	Participates in the control of copper homeostasis
A6J30_RS06110	COG0704	Plays a role in the regulation of phosphate uptake
A6J30_RS06115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J30_RS06120	COG0581	inorganic phosphate transmembrane transporter activity
A6J30_RS06130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6J30_RS06135	COG0248	Ppx GppA phosphatase
A6J30_RS06145	COG5002	protein histidine kinase activity
A6J30_RS06150	COG0745	RESPONSE REGULATOR receiver
A6J30_RS06160	COG2974	May be involved in recombination
A6J30_RS06165	COG0826	peptidase U32
A6J30_RS06170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J30_RS06230	COG0542	response to heat
A6J30_RS06240	COG0564	pseudouridine synthase activity
A6J30_RS06245	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J30_RS06250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6J30_RS06255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6J30_RS06260	COG0077	Prephenate dehydratase
A6J30_RS06260	COG1605	Chorismate mutase
A6J30_RS06265	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A6J30_RS06270	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A6J30_RS06280	COG0488	(ABC) transporter
A6J30_RS06295	COG0739	heme binding
A6J30_RS06300	COG0287	Prephenate dehydrogenase
A6J30_RS06300	COG1605	Chorismate mutase
A6J30_RS06305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J30_RS06310	COG1472	Belongs to the glycosyl hydrolase 3 family
A6J30_RS06315	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6J30_RS06320	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6J30_RS06335	COG1966	Carbon starvation protein
A6J30_RS06340	COG3275	phosphorelay sensor kinase activity
A6J30_RS06345	COG3279	Response regulator of the LytR AlgR family
A6J30_RS06350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6J30_RS06355	COG1047	Peptidyl-prolyl cis-trans
A6J30_RS06360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6J30_RS06365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6J30_RS06370	COG0196	riboflavin kinase activity
A6J30_RS06375	COG0728	peptidoglycan biosynthetic process
A6J30_RS06380	COG0268	Binds directly to 16S ribosomal RNA
A6J30_RS06390	COG0640	Transcriptional regulator
A6J30_RS06400	COG0583	DNA-binding transcription factor activity
A6J30_RS06405	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6J30_RS06415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6J30_RS06420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6J30_RS06425	COG0730	response to heat
A6J30_RS06435	COG0494	nUDIX hydrolase
A6J30_RS06445	COG3066	DNA modification
A6J30_RS06455	COG0667	Aldo Keto reductase
A6J30_RS06470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6J30_RS06480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6J30_RS06485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J30_RS06490	COG4974	Belongs to the 'phage' integrase family
A6J30_RS06495	COG0716	FMN binding
A6J30_RS06505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6J30_RS06510	COG0513	Belongs to the DEAD box helicase family
A6J30_RS06515	COG3022	response to hydroperoxide
A6J30_RS06520	COG1115	amino acid carrier protein
A6J30_RS06535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6J30_RS06545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6J30_RS06550	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A6J30_RS06555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6J30_RS06560	COG0083	homoserine kinase activity
A6J30_RS06575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6J30_RS06590	COG0745	RESPONSE REGULATOR receiver
A6J30_RS06600	COG0784	Response regulator, receiver
A6J30_RS06600	COG2198	Histidine kinase
A6J30_RS06600	COG5002	protein histidine kinase activity
A6J30_RS06605	COG3706	GGDEF domain
A6J30_RS06605	COG5001	Diguanylate cyclase
A6J30_RS06605	COG4251	negative regulation of phosphorylation
A6J30_RS06605	COG2203	Gaf domain
A6J30_RS06610	COG1242	4 iron, 4 sulfur cluster binding
A6J30_RS06615	COG0070	glutamate synthase
A6J30_RS06615	COG0067	glutamate synthase
A6J30_RS06615	COG0069	glutamate synthase activity
A6J30_RS06625	COG0069	glutamate synthase activity
A6J30_RS06625	COG0067	glutamate synthase
A6J30_RS06625	COG0070	glutamate synthase
A6J30_RS06630	COG0493	'glutamate synthase
A6J30_RS06640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J30_RS06650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J30_RS06655	COG2860	membrane
A6J30_RS06660	COG0583	DNA-binding transcription factor activity
A6J30_RS06665	COG0730	response to heat
A6J30_RS06680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6J30_RS06685	COG0505	Belongs to the CarA family
A6J30_RS06690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6J30_RS06695	COG0494	nUDIX hydrolase
A6J30_RS06700	COG0653	protein targeting
A6J30_RS06710	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6J30_RS06715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6J30_RS06720	COG0849	cell division
A6J30_RS06725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6J30_RS06730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J30_RS06735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6J30_RS06740	COG0772	Belongs to the SEDS family
A6J30_RS06745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6J30_RS06750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J30_RS06755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J30_RS06760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6J30_RS06765	COG0768	penicillin binding
A6J30_RS06770	COG3116	cell division
A6J30_RS06775	COG0275	rRNA processing
A6J30_RS06790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6J30_RS06800	COG0792	nuclease activity
A6J30_RS06805	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6J30_RS06810	COG2823	Periplasmic or secreted lipoprotein
A6J30_RS06815	COG2969	positive regulation of protein catabolic process
A6J30_RS06820	COG0625	glutathione transferase activity
A6J30_RS06825	COG2857	Cytochrome c1
A6J30_RS06830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6J30_RS06835	COG0723	plastoquinol--plastocyanin reductase activity
A6J30_RS06840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6J30_RS06845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6J30_RS06855	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6J30_RS06865	COG3105	Protein conserved in bacteria
A6J30_RS06875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J30_RS06880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J30_RS06890	COG3150	esterase
A6J30_RS06900	COG3151	Protein conserved in bacteria
A6J30_RS06905	COG0494	nUDIX hydrolase
A6J30_RS06910	COG1538	Outer membrane efflux protein
A6J30_RS06915	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6J30_RS06915	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6J30_RS06920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6J30_RS06935	COG3025	triphosphatase activity
A6J30_RS06940	COG1392	Phosphate transport regulator
A6J30_RS06945	COG0306	phosphate transporter
A6J30_RS06950	COG4991	sh3 domain protein
A6J30_RS06960	COG3409	Peptidoglycan-binding domain 1 protein
A6J30_RS06960	COG3267	Type II secretory pathway component ExeA
A6J30_RS06965	COG0617	tRNA 3'-terminal CCA addition
A6J30_RS06970	COG1968	undecaprenyl-diphosphatase activity
A6J30_RS06975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J30_RS06980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6J30_RS06985	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6J30_RS06990	COG0596	Alpha beta hydrolase
A6J30_RS06995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6J30_RS07000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6J30_RS07005	COG1610	YqeY-like protein
A6J30_RS07010	COG0358	DNA primase activity
A6J30_RS07030	COG3550	peptidyl-serine autophosphorylation
A6J30_RS07110	COG0732	type I restriction modification DNA specificity domain
A6J30_RS07155	COG1464	Belongs to the NlpA lipoprotein family
A6J30_RS07165	COG2207	Transcriptional regulator
A6J30_RS07200	COG2213	PTS system mannitol-specific
A6J30_RS07200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J30_RS07205	COG0246	Mannitol dehydrogenase
A6J30_RS07210	COG3722	fumarate hydratase activity
A6J30_RS07225	COG1461	Dihydroxyacetone kinase
A6J30_RS07230	COG2376	Dihydroxyacetone kinase
A6J30_RS07240	COG5002	protein histidine kinase activity
A6J30_RS07255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6J30_RS07260	COG1349	DNA-binding transcription factor activity
A6J30_RS07270	COG0469	pyruvate kinase activity
A6J30_RS07285	COG0440	acetolactate synthase activity
A6J30_RS07290	COG0028	Belongs to the TPP enzyme family
A6J30_RS07295	COG1022	Amp-dependent synthetase and ligase
A6J30_RS07300	COG0583	DNA-binding transcription factor activity
A6J30_RS07320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6J30_RS07325	COG0473	3-isopropylmalate dehydrogenase activity
A6J30_RS07330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6J30_RS07335	COG0066	3-isopropylmalate dehydratase activity
A6J30_RS07345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6J30_RS07350	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6J30_RS07355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J30_RS07360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6J30_RS07365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J30_RS07370	COG2967	ApaG domain
A6J30_RS07375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6J30_RS07390	COG2966	Psort location CytoplasmicMembrane, score
A6J30_RS07395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6J30_RS07405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6J30_RS07410	COG0142	geranyltranstransferase activity
A6J30_RS07420	COG0039	L-malate dehydrogenase activity
A6J30_RS07435	COG2358	TRAP transporter, solute receptor (TAXI family
A6J30_RS07455	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6J30_RS07460	COG1178	ABC-type Fe3 transport system permease component
A6J30_RS07465	COG4143	(ABC) transporter
A6J30_RS07470	COG0163	prenyltransferase activity
A6J30_RS07475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J30_RS07485	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6J30_RS07490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6J30_RS07500	COG2105	PFAM AIG2 family protein
A6J30_RS07510	COG0729	surface antigen
A6J30_RS07515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J30_RS07525	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6J30_RS07540	COG4181	ATPase activity
A6J30_RS07560	COG0529	Catalyzes the synthesis of activated sulfate
A6J30_RS07565	COG0471	metal ion transport
A6J30_RS07565	COG3273	potassium ion transport
A6J30_RS07575	COG2895	sulfate adenylyltransferase (ATP) activity
A6J30_RS07580	COG0175	sulfate reduction
A6J30_RS07585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6J30_RS07585	COG1648	precorrin-2 dehydrogenase activity
A6J30_RS07600	COG0513	Belongs to the DEAD box helicase family
A6J30_RS07605	COG2153	protein acetylation
A6J30_RS07615	COG0545	Peptidyl-prolyl cis-trans isomerase
A6J30_RS07625	COG0203	ribosomal protein L17
A6J30_RS07630	COG0202	RNA polymerase activity
A6J30_RS07640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6J30_RS07645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6J30_RS07650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J30_RS07655	COG0201	protein transport
A6J30_RS07660	COG0200	Binds to the 23S rRNA
A6J30_RS07665	COG1841	ribosomal large subunit assembly
A6J30_RS07680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6J30_RS07685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6J30_RS07690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6J30_RS07695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6J30_RS07700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6J30_RS07705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6J30_RS07710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6J30_RS07715	COG0255	Belongs to the universal ribosomal protein uL29 family
A6J30_RS07725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6J30_RS07730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6J30_RS07735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6J30_RS07740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6J30_RS07750	COG0088	Forms part of the polypeptide exit tunnel
A6J30_RS07755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6J30_RS07765	COG0254	rRNA binding
A6J30_RS07775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J30_RS07780	COG1609	Transcriptional regulator
A6J30_RS07790	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6J30_RS07795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6J30_RS07800	COG1575	Belongs to the MenA family. Type 1 subfamily
A6J30_RS07805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6J30_RS07810	COG3074	FtsZ-dependent cytokinesis
A6J30_RS07820	COG1494	fructose-1,6-bisphosphatase
A6J30_RS07845	COG0149	triose-phosphate isomerase activity
A6J30_RS07850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6J30_RS07870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J30_RS07885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J30_RS07965	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J30_RS07970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J30_RS07975	COG1560	Kdo2-lipid A biosynthetic process
A6J30_RS07980	COG0859	PFAM glycosyl transferase family 9
A6J30_RS07985	COG1519	Transferase
A6J30_RS08005	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS08015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6J30_RS08030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J30_RS08040	COG2089	acid synthase
A6J30_RS08045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6J30_RS08050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J30_RS08060	COG3642	lipopolysaccharide core region biosynthetic process
A6J30_RS08065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6J30_RS08070	COG0859	PFAM glycosyl transferase family 9
A6J30_RS08075	COG0463	Glycosyl transferase, family 2
A6J30_RS08090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6J30_RS08095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6J30_RS08105	COG2194	sulfuric ester hydrolase activity
A6J30_RS08115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6J30_RS08120	COG2003	Belongs to the UPF0758 family
A6J30_RS08135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J30_RS08140	COG1309	transcriptional regulator
A6J30_RS08145	COG1560	Kdo2-lipid A biosynthetic process
A6J30_RS08150	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6J30_RS08155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6J30_RS08165	COG1561	YicC-like family, N-terminal region
A6J30_RS08175	COG4608	Belongs to the ABC transporter superfamily
A6J30_RS08180	COG0444	Belongs to the ABC transporter superfamily
A6J30_RS08185	COG0747	negative chemotaxis
A6J30_RS08190	COG4239	(ABC) transporter, permease
A6J30_RS08195	COG4174	ABC transporter (Permease)
A6J30_RS08220	COG0811	peptide transport
A6J30_RS08225	COG0848	biopolymer transport protein
A6J30_RS08240	COG0194	GDP metabolic process
A6J30_RS08245	COG1758	RNA polymerase activity
A6J30_RS08250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J30_RS08255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J30_RS08260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J30_RS08270	COG2233	PERMEase
A6J30_RS08290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J30_RS08300	COG2183	response to ionizing radiation
A6J30_RS08310	COG0596	Alpha beta hydrolase
A6J30_RS08315	COG1040	competence protein
A6J30_RS08320	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6J30_RS08320	COG0316	Belongs to the HesB IscA family
A6J30_RS08325	COG0494	nUDIX hydrolase
A6J30_RS08330	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6J30_RS08340	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6J30_RS08345	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6J30_RS08350	COG3156	type II secretion system protein K
A6J30_RS08355	COG4795	General secretion pathway protein
A6J30_RS08360	COG2165	general secretion pathway protein
A6J30_RS08365	COG2165	general secretion pathway protein
A6J30_RS08370	COG2165	general secretion pathway protein
A6J30_RS08375	COG1459	type II secretion system
A6J30_RS08380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J30_RS08390	COG3031	protein transport across the cell outer membrane
A6J30_RS08395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J30_RS08400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6J30_RS08405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6J30_RS08415	COG0456	acetyltransferase
A6J30_RS08420	COG1490	D-aminoacyl-tRNA deacylase activity
A6J30_RS08425	COG1295	ribonuclease BN
A6J30_RS08440	COG1217	gtp-binding protein TYPA
A6J30_RS08445	COG0174	glutamine synthetase
A6J30_RS08455	COG3852	Histidine kinase
A6J30_RS08460	COG2204	response regulator
A6J30_RS08470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6J30_RS08485	COG3078	GTPase activator activity
A6J30_RS08505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6J30_RS08515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J30_RS08515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J30_RS08540	COG0084	hydrolase, TatD family'
A6J30_RS08550	COG0805	protein transport
A6J30_RS08555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J30_RS08560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J30_RS08565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6J30_RS08570	COG3165	ubiquinone biosynthetic process from chorismate
A6J30_RS08575	COG2226	methyltransferase
A6J30_RS08580	COG1322	Protein conserved in bacteria
A6J30_RS08595	COG0628	permease
A6J30_RS08625	COG1597	lipid kinase activity
A6J30_RS08655	COG2081	HI0933 family
A6J30_RS08665	COG1528	Iron-storage protein
A6J30_RS08670	COG0589	response to stress
A6J30_RS08685	COG0742	ribosomal rna small subunit methyltransferase
A6J30_RS08690	COG5002	protein histidine kinase activity
A6J30_RS08690	COG5001	Diguanylate cyclase
A6J30_RS08695	COG1522	sequence-specific DNA binding
A6J30_RS08700	COG0339	signal peptide processing
A6J30_RS08710	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6J30_RS08715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J30_RS08720	COG0583	DNA-binding transcription factor activity
A6J30_RS08725	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6J30_RS08730	COG0800	Aldolase
A6J30_RS08735	COG2610	gluconate transmembrane transporter activity
A6J30_RS08740	COG3265	gluconokinase activity
A6J30_RS08745	COG0129	dihydroxy-acid dehydratase activity
A6J30_RS08760	COG0583	DNA-binding transcription factor activity
A6J30_RS08765	COG1609	Transcriptional regulator
A6J30_RS08805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J30_RS08810	COG0601	transmembrane transport
A6J30_RS08815	COG0747	negative chemotaxis
A6J30_RS08820	COG4172	Belongs to the ABC transporter superfamily
A6J30_RS08885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J30_RS08890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J30_RS08900	COG2960	long-chain fatty acid transporting porin activity
A6J30_RS08905	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6J30_RS08910	COG0583	DNA-binding transcription factor activity
A6J30_RS08960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J30_RS08965	COG1739	Uncharacterized protein family UPF0029
A6J30_RS08970	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J30_RS08970	COG1024	Enoyl-CoA hydratase
A6J30_RS08975	COG0183	Belongs to the thiolase family
A6J30_RS08980	COG0604	alcohol dehydrogenase
A6J30_RS08995	COG0425	Belongs to the sulfur carrier protein TusA family
A6J30_RS09005	COG2119	membrane
A6J30_RS09010	COG0752	glycyl-tRNA synthetase alpha subunit
A6J30_RS09015	COG0751	glycine-tRNA ligase activity
A6J30_RS09020	COG0366	Alpha amylase catalytic
A6J30_RS09025	COG3977	Valine--pyruvate aminotransferase
A6J30_RS09030	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J30_RS09050	COG0187	DNA topoisomerase II activity
A6J30_RS09055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6J30_RS09060	COG0592	DNA-directed DNA polymerase activity
A6J30_RS09065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6J30_RS09090	COG1126	abc transporter atp-binding protein
A6J30_RS09100	COG0594	ribonuclease P activity
A6J30_RS09110	COG0706	membrane insertase activity
A6J30_RS09115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J30_RS09120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6J30_RS09125	COG0445	tRNA wobble uridine modification
A6J30_RS09130	COG0357	Ribosomal RNA small subunit methyltransferase G
A6J30_RS09135	COG1192	Involved in chromosome partitioning
A6J30_RS09140	COG1475	DNA binding
A6J30_RS09145	COG3312	ion transport
A6J30_RS09150	COG0356	it plays a direct role in the translocation of protons across the membrane
A6J30_RS09165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J30_RS09170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6J30_RS09175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6J30_RS09180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6J30_RS09185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6J30_RS09190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6J30_RS09195	COG0765	amino acid transport
A6J30_RS09200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J30_RS09205	COG2814	Major facilitator Superfamily
A6J30_RS09210	COG0583	DNA-binding transcription factor activity
A6J30_RS09220	COG0129	dihydroxy-acid dehydratase activity
A6J30_RS09225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J30_RS09230	COG3978	acetolactate synthase activity
A6J30_RS09240	COG0606	chelatase, subunit chli
A6J30_RS09250	COG0204	Acyl-transferase
A6J30_RS09255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J30_RS09260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6J30_RS09270	COG3084	Protein conserved in bacteria
A6J30_RS09280	COG4326	sporulation control protein
A6J30_RS09285	COG1272	protein, Hemolysin III
A6J30_RS09295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J30_RS09300	COG0569	domain protein
A6J30_RS09305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J30_RS09305	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J30_RS09310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J30_RS09315	COG0242	peptide deformylase activity
A6J30_RS09325	COG0758	DNA mediated transformation
A6J30_RS09330	COG2922	Belongs to the Smg family
A6J30_RS09335	COG0551	DNA topoisomerase type I activity
A6J30_RS09340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6J30_RS09345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J30_RS09350	COG0009	L-threonylcarbamoyladenylate synthase
A6J30_RS09355	COG0408	coproporphyrinogen oxidase activity
A6J30_RS09360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6J30_RS09370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6J30_RS09435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6J30_RS09440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6J30_RS09445	COG0352	thiamine-phosphate diphosphorylase activity
A6J30_RS09450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J30_RS09455	COG2104	thiamine diphosphate biosynthetic process
A6J30_RS09460	COG2022	thiamine diphosphate biosynthetic process
A6J30_RS09470	COG0006	proline dipeptidase activity
A6J30_RS09470	COG0006	proline dipeptidase activity
A6J30_RS09500	COG3220	belongs to the UPF0276 family
A6J30_RS09510	COG0210	DNA helicase
A6J30_RS09520	COG0405	Gamma-glutamyltransferase
A6J30_RS09525	COG1280	lysine exporter protein (LysE YggA)
A6J30_RS09535	COG2962	Rard protein
A6J30_RS09540	COG0514	ATP-dependent DNA helicase (RecQ)
A6J30_RS09555	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6J30_RS09560	COG0248	Ppx GppA phosphatase
A6J30_RS09565	COG0513	Belongs to the DEAD box helicase family
A6J30_RS09570	COG3118	belongs to the thioredoxin family
A6J30_RS09590	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6J30_RS09595	COG0633	Ferredoxin
A6J30_RS09645	COG3071	HemY protein
A6J30_RS09650	COG2959	enzyme of heme biosynthesis
A6J30_RS09655	COG1587	Uroporphyrinogen-III synthase
A6J30_RS09660	COG0181	hydroxymethylbilane synthase activity
A6J30_RS09665	COG3072	Adenylate cyclase
A6J30_RS09670	COG1965	Belongs to the frataxin family
A6J30_RS09680	COG0019	diaminopimelate decarboxylase activity
A6J30_RS09685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6J30_RS09695	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6J30_RS09700	COG1011	Hydrolase
A6J30_RS09705	COG2199	diguanylate cyclase activity
A6J30_RS09705	COG2200	EAL domain
A6J30_RS09705	COG3287	FIST C domain
A6J30_RS09710	COG3148	PFAM DTW domain containing protein
A6J30_RS09725	COG0561	phosphatase activity
A6J30_RS09735	COG2267	carboxylic ester hydrolase activity
A6J30_RS09740	COG1280	lysine exporter protein (LysE YggA)
A6J30_RS09745	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6J30_RS09750	COG0640	Transcriptional regulator
A6J30_RS09755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J30_RS09810	COG2095	MarC family integral membrane protein
A6J30_RS09820	COG0742	ribosomal rna small subunit methyltransferase
A6J30_RS09825	COG0552	protein localization to endoplasmic reticulum
A6J30_RS09830	COG2884	Cell division ATP-binding protein ftsE
A6J30_RS09835	COG2177	Part of the ABC transporter FtsEX involved in
A6J30_RS09850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J30_RS09855	COG0705	Rhomboid family
A6J30_RS09860	COG1580	Controls the rotational direction of flagella during chemotaxis
A6J30_RS09865	COG3161	chorismate lyase activity
A6J30_RS09870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6J30_RS09875	COG2937	Belongs to the GPAT DAPAT family
A6J30_RS09890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6J30_RS09895	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A6J30_RS09900	COG0534	Mate efflux family protein
A6J30_RS09905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J30_RS09920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J30_RS09925	COG4206	TonB-dependent receptor
A6J30_RS09935	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6J30_RS09995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J30_RS10005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6J30_RS10040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J30_RS10050	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J30_RS10055	COG0250	Participates in transcription elongation, termination and antitermination
A6J30_RS10060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6J30_RS10065	COG0081	regulation of translation
A6J30_RS10070	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6J30_RS10075	COG0222	ribosome binding
A6J30_RS10080	COG0085	RNA polymerase activity
A6J30_RS10085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6J30_RS10090	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6J30_RS10095	COG2816	NAD+ diphosphatase activity
A6J30_RS10110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6J30_RS10115	COG1573	uracil-dna glycosylase
A6J30_RS10120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J30_RS10130	COG1253	flavin adenine dinucleotide binding
A6J30_RS10200	COG0151	Belongs to the GarS family
A6J30_RS10210	COG0138	bifunctional purine biosynthesis protein purh
A6J30_RS10220	COG0789	Transcriptional regulator
A6J30_RS10225	COG3710	Transcriptional regulator
A6J30_RS10235	COG0531	amino acid
A6J30_RS10240	COG1982	Orn Lys Arg decarboxylase major
A6J30_RS10325	COG3706	GGDEF domain
A6J30_RS10330	COG0488	(ABC) transporter
A6J30_RS10335	COG2814	Major facilitator Superfamily
A6J30_RS10340	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6J30_RS10345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J30_RS10350	COG2264	protein methyltransferase activity
A6J30_RS10360	COG0439	Biotin carboxylase
A6J30_RS10365	COG0511	ligase activity, forming carbon-carbon bonds
A6J30_RS10370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6J30_RS10375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J30_RS10390	COG2814	Major facilitator Superfamily
A6J30_RS10395	COG0784	Response regulator, receiver
A6J30_RS10395	COG2205	protein histidine kinase activity
A6J30_RS10420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J30_RS10430	COG3263	regulation of cellular component size
A6J30_RS10440	COG4232	protein-disulfide reductase activity
A6J30_RS10445	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6J30_RS10450	COG1027	Aspartate ammonia-lyase
A6J30_RS10455	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6J30_RS10460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6J30_RS10470	COG2205	protein histidine kinase activity
A6J30_RS10475	COG0745	RESPONSE REGULATOR receiver
A6J30_RS10485	COG3678	ATP-independent chaperone mediated protein folding
A6J30_RS10495	COG0205	6-phosphofructokinase activity
A6J30_RS10500	COG0534	Mate efflux family protein
A6J30_RS10510	COG0459	protein refolding
A6J30_RS10530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J30_RS10540	COG1509	lysine 2,3-aminomutase activity
A6J30_RS10545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J30_RS10555	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6J30_RS10560	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6J30_RS10565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J30_RS10570	COG1053	succinate dehydrogenase
A6J30_RS10580	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A6J30_RS10600	COG4942	peptidase
A6J30_RS10605	COG1045	serine acetyltransferase
A6J30_RS10610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6J30_RS10615	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6J30_RS10620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J30_RS10625	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6J30_RS10640	COG0471	metal ion transport
A6J30_RS10645	COG0688	phosphatidylethanolamine metabolic process
A6J30_RS10650	COG1162	GTPase activity
A6J30_RS10655	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6J30_RS10725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6J30_RS10730	COG0802	atpase or kinase
A6J30_RS10735	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6J30_RS10740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6J30_RS10745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6J30_RS10755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J30_RS10760	COG0330	HflC and HflK could
A6J30_RS10765	COG0330	HflC and HflK could
A6J30_RS10770	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6J30_RS10775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6J30_RS10785	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A6J30_RS10790	COG1017	nitric oxide dioxygenase activity
A6J30_RS10790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J30_RS10795	COG1959	2 iron, 2 sulfur cluster binding
A6J30_RS10800	COG0557	exoribonuclease II activity
A6J30_RS10805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J30_RS10810	COG0546	phosphoglycolate phosphatase activity
A6J30_RS10815	COG0180	Tryptophanyl-tRNA synthetase
A6J30_RS10845	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J30_RS10850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6J30_RS10860	COG1012	belongs to the aldehyde dehydrogenase family
A6J30_RS10870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J30_RS10875	COG3954	Phosphoribulokinase
A6J30_RS10880	COG3089	Belongs to the UPF0270 family
A6J30_RS10885	COG0429	hydrolase of the alpha beta-hydrolase fold
A6J30_RS10895	COG0488	(ABC) transporter
A6J30_RS10905	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J30_RS10920	COG1047	Peptidyl-prolyl cis-trans
A6J30_RS10930	COG1446	asparaginase
A6J30_RS10935	COG2900	Belongs to the SlyX family
A6J30_RS10945	COG0545	Peptidyl-prolyl cis-trans isomerase
A6J30_RS10950	COG2964	Protein conserved in bacteria
A6J30_RS10955	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6J30_RS10960	COG2923	Belongs to the DsrF TusC family
A6J30_RS10965	COG2168	tRNA wobble position uridine thiolation
A6J30_RS10975	COG0049	tRNA binding
A6J30_RS10980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J30_RS10985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J30_RS10990	COG2906	2 iron, 2 sulfur cluster binding
A6J30_RS11000	COG0281	malic enzyme
A6J30_RS11010	COG0626	cystathionine gamma-synthase activity
A6J30_RS11015	COG0460	homoserine dehydrogenase
A6J30_RS11015	COG0527	aspartate kinase activity
A6J30_RS11020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6J30_RS11030	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6J30_RS11035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J30_RS11040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6J30_RS11045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6J30_RS11050	COG0137	argininosuccinate synthase activity
A6J30_RS11055	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6J30_RS11055	COG0165	Argininosuccinate lyase
A6J30_RS11070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J30_RS11070	COG0678	peroxiredoxin activity
A6J30_RS11080	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6J30_RS11110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6J30_RS11115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6J30_RS11125	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6J30_RS11130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6J30_RS11135	COG0360	Binds together with S18 to 16S ribosomal RNA
A6J30_RS11140	COG2965	DNA replication, synthesis of RNA primer
A6J30_RS11150	COG0359	binds to the 23S rRNA
A6J30_RS11165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J30_RS11175	COG0432	Pfam Uncharacterised protein family UPF0047
A6J30_RS11180	COG0166	Belongs to the GPI family
A6J30_RS11190	COG0735	belongs to the Fur family
A6J30_RS11200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J30_RS11225	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6J30_RS11230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6J30_RS11235	COG0175	sulfate reduction
A6J30_RS11320	COG0646	methionine synthase
A6J30_RS11320	COG1410	methionine synthase
A6J30_RS11325	COG0527	aspartate kinase activity
A6J30_RS11335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6J30_RS11345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6J30_RS11360	COG0629	single-stranded DNA binding
A6J30_RS11365	COG2199	diguanylate cyclase activity
A6J30_RS11365	COG2200	EAL domain
A6J30_RS11390	COG3409	Peptidoglycan-binding domain 1 protein
A6J30_RS11390	COG3267	Type II secretory pathway component ExeA
A6J30_RS11400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J30_RS11405	COG1459	type II secretion system
A6J30_RS11415	COG2165	general secretion pathway protein
A6J30_RS11450	COG1077	Cell shape determining protein MreB Mrl
A6J30_RS11455	COG1792	Involved in formation and maintenance of cell shape
A6J30_RS11460	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6J30_RS11465	COG0424	maF-like protein
A6J30_RS11475	COG3164	Protein of unknown function
A6J30_RS11480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J30_RS11485	COG0312	modulator of DNA gyrase
A6J30_RS11490	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6J30_RS11495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6J30_RS11510	COG0564	pseudouridine synthase activity
A6J30_RS11515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J30_RS11520	COG3028	Belongs to the UPF0307 family
A6J30_RS11525	COG0312	modulator of DNA gyrase
A6J30_RS11530	COG2239	Acts as a magnesium transporter
A6J30_RS11535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J30_RS11540	COG1660	Displays ATPase and GTPase activities
A6J30_RS11545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J30_RS11550	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6J30_RS11560	COG1137	ATPase activity
A6J30_RS11565	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6J30_RS11575	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6J30_RS11575	COG0517	IMP dehydrogenase activity
A6J30_RS11585	COG1127	ABC transporter
A6J30_RS11590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J30_RS11595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J30_RS11600	COG2854	intermembrane phospholipid transfer
A6J30_RS11610	COG5007	Belongs to the BolA IbaG family
A6J30_RS11615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J30_RS11620	COG0204	Acyl-transferase
A6J30_RS11625	COG0251	oxidation-reduction process
A6J30_RS11630	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A6J30_RS11635	COG0540	Belongs to the ATCase OTCase family
A6J30_RS11645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6J30_RS11650	COG2235	arginine
A6J30_RS11680	COG0525	valine-tRNA ligase activity
A6J30_RS11685	COG2927	DNA polymerase III (CHI subunit)
A6J30_RS11690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6J30_RS11695	COG0795	lipopolysaccharide-transporting ATPase activity
A6J30_RS11700	COG0795	lipopolysaccharide-transporting ATPase activity
A6J30_RS11715	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS11725	COG0726	polysaccharide deacetylase
A6J30_RS11730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J30_RS11735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J30_RS11740	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J30_RS11745	COG1486	melibiose metabolic process
A6J30_RS11750	COG3394	polysaccharide catabolic process
A6J30_RS11760	COG3437	response regulator, receiver
A6J30_RS11810	COG1012	belongs to the aldehyde dehydrogenase family
A6J30_RS11880	COG0741	lytic transglycosylase activity
A6J30_RS11885	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A6J30_RS11895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J30_RS11905	COG2066	Belongs to the glutaminase family
A6J30_RS11910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J30_RS11915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6J30_RS11925	COG1872	DUF167
A6J30_RS11930	COG0762	integral membrane protein
A6J30_RS11935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J30_RS11940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J30_RS11955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6J30_RS11960	COG1678	Uncharacterized ACR, COG1678
A6J30_RS11965	COG0189	ligase activity
A6J30_RS11970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J30_RS11975	COG2356	endonuclease I
A6J30_RS11980	COG3091	SprT-like family
A6J30_RS11990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6J30_RS12000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6J30_RS12005	COG0583	DNA-binding transcription factor activity
A6J30_RS12010	COG4771	TonB-dependent receptor
A6J30_RS12015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J30_RS12020	COG0126	phosphoglycerate kinase activity
A6J30_RS12025	COG0191	fructose-bisphosphate aldolase activity
A6J30_RS12030	COG0668	transmembrane transport
A6J30_RS12035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6J30_RS12045	COG0583	DNA-binding transcription factor activity
A6J30_RS12055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J30_RS12060	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6J30_RS12065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6J30_RS12075	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A6J30_RS12085	COG3079	Belongs to the UPF0149 family
A6J30_RS12090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J30_RS12095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J30_RS12110	COG0354	folic acid binding
A6J30_RS12115	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6J30_RS12125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6J30_RS12135	COG1595	DNA-templated transcription, initiation
A6J30_RS12140	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A6J30_RS12150	COG3086	response to oxidative stress
A6J30_RS12155	COG0481	GTPase activity
A6J30_RS12165	COG0571	ribonuclease III activity
A6J30_RS12170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6J30_RS12175	COG1381	Involved in DNA repair and RecF pathway recombination
A6J30_RS12180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6J30_RS12185	COG0736	holo-[acyl-carrier-protein] synthase activity
A6J30_RS12200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J30_RS12210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J30_RS12215	COG3956	TIGRFAM MazG family protein
A6J30_RS12220	COG0504	CTP synthase activity
A6J30_RS12225	COG0148	phosphopyruvate hydratase activity
A6J30_RS12230	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6J30_RS12235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6J30_RS12240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6J30_RS12245	COG0585	pseudouridine synthase activity
A6J30_RS12250	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6J30_RS12255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6J30_RS12270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6J30_RS12275	COG1546	Belongs to the CinA family
A6J30_RS12280	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6J30_RS12285	COG2137	regulation of response to DNA damage stimulus
A6J30_RS12290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J30_RS12295	COG0527	aspartate kinase activity
A6J30_RS12355	COG3630	sodium ion export across plasma membrane
A6J30_RS12360	COG5016	pyruvate
A6J30_RS12360	COG0511	ligase activity, forming carbon-carbon bonds
A6J30_RS12365	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6J30_RS12375	COG1238	metal cluster binding
A6J30_RS12380	COG0612	Peptidase, M16
A6J30_RS12385	COG2918	glutathione biosynthetic process
A6J30_RS12395	COG1854	S-ribosylhomocysteine lyase activity
A6J30_RS12400	COG4536	flavin adenine dinucleotide binding
A6J30_RS12405	COG4137	Cytochrome C assembly protein
A6J30_RS12410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J30_RS12415	COG0228	four-way junction DNA binding
A6J30_RS12420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6J30_RS12425	COG0336	Belongs to the RNA methyltransferase TrmD family
A6J30_RS12430	COG0335	large ribosomal subunit rRNA binding
A6J30_RS12435	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6J30_RS12440	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6J30_RS12445	COG0237	dephospho-CoA kinase activity
A6J30_RS12455	COG1459	type II secretion system
A6J30_RS12460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J30_RS12470	COG0157	Belongs to the NadC ModD family
A6J30_RS12480	COG2186	Transcriptional regulator
A6J30_RS12485	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6J30_RS12490	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J30_RS12495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J30_RS12510	COG0288	reversible hydration of carbon dioxide
A6J30_RS12515	COG0659	secondary active sulfate transmembrane transporter activity
A6J30_RS12525	COG1131	(ABC) transporter
A6J30_RS12530	COG0842	Transport permease protein
A6J30_RS12540	COG1560	Kdo2-lipid A biosynthetic process
A6J30_RS12550	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6J30_RS12555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6J30_RS12560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J30_RS12575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J30_RS12590	COG1489	DNA binding
A6J30_RS12595	COG1643	Atp-dependent helicase
A6J30_RS12600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J30_RS12605	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6J30_RS12610	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6J30_RS12615	COG3112	Uncharacterised protein family (UPF0231)
A6J30_RS12625	COG0004	ammonium transporteR
A6J30_RS12630	COG1840	ABC-type Fe3 transport system, periplasmic component
A6J30_RS12640	COG3842	ATPase activity
A6J30_RS12645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J30_RS12660	COG2971	BadF BadG BcrA BcrD
A6J30_RS12670	COG4608	Belongs to the ABC transporter superfamily
A6J30_RS12675	COG0444	Belongs to the ABC transporter superfamily
A6J30_RS12680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J30_RS12690	COG0747	negative chemotaxis
A6J30_RS12695	COG0784	Response regulator, receiver
A6J30_RS12695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J30_RS12695	COG2205	protein histidine kinase activity
A6J30_RS12695	COG2198	Histidine kinase
A6J30_RS12705	COG2813	Specifically methylates the guanine in position
A6J30_RS12710	COG0628	permease
A6J30_RS12715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6J30_RS12720	COG0316	Belongs to the HesB IscA family
A6J30_RS12730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J30_RS12735	COG0739	heme binding
A6J30_RS12740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J30_RS12750	COG2027	D-alanyl-D-alanine carboxypeptidase
A6J30_RS12755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6J30_RS12760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J30_RS12765	COG1534	Rna-binding protein
A6J30_RS12770	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6J30_RS12775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J30_RS12780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6J30_RS12785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J30_RS12795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J30_RS12810	COG0779	Required for maturation of 30S ribosomal subunits
A6J30_RS12815	COG0195	Participates in both transcription termination and antitermination
A6J30_RS12820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6J30_RS12825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6J30_RS12830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6J30_RS12835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6J30_RS12840	COG1185	polyribonucleotide nucleotidyltransferase activity
A6J30_RS12855	COG0534	Mate efflux family protein
A6J30_RS12860	COG0826	peptidase U32
A6J30_RS12865	COG0826	peptidase U32
A6J30_RS12875	COG3154	lipid carrier protein
A6J30_RS12880	COG3153	acetyltransferase
A6J30_RS12900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6J30_RS12910	COG0084	hydrolase, TatD family'
A6J30_RS12915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J30_RS12920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6J30_RS12925	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A6J30_RS12930	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6J30_RS12935	COG0813	purine-nucleoside phosphorylase activity
A6J30_RS12945	COG0560	Phosphoserine phosphatase
A6J30_RS12955	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6J30_RS12960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J30_RS12965	COG0583	DNA-binding transcription factor activity
A6J30_RS12975	COG1022	Amp-dependent synthetase and ligase
A6J30_RS12980	COG2169	Transcriptional regulator
A6J30_RS13005	COG4964	Belongs to the GSP D family
A6J30_RS13065	COG0583	DNA-binding transcription factor activity
A6J30_RS13070	COG0531	amino acid
A6J30_RS13075	COG2731	YhcH YjgK YiaL family protein
A6J30_RS13080	COG3250	beta-galactosidase activity
A6J30_RS13085	COG1609	Transcriptional regulator
A6J30_RS13095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J30_RS13105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6J30_RS13110	COG2017	converts alpha-aldose to the beta-anomer
A6J30_RS13115	COG1609	Transcriptional regulator
A6J30_RS13125	COG2211	Major facilitator Superfamily
A6J30_RS13130	COG1609	Transcriptional regulator
A6J30_RS13135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J30_RS13150	COG0598	Magnesium transport protein CorA
A6J30_RS13155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6J30_RS13160	COG1349	DNA-binding transcription factor activity
A6J30_RS13165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6J30_RS13170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J30_RS13185	COG2271	Major facilitator Superfamily
A6J30_RS13190	COG0584	glycerophosphoryl diester phosphodiesterase
A6J30_RS13195	COG2171	N-acyltransferase activity
A6J30_RS13200	COG3141	response to X-ray
A6J30_RS13220	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6J30_RS13230	COG1074	ATP-dependent DNA helicase activity
A6J30_RS13235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J30_RS13245	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6J30_RS13245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6J30_RS13260	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6J30_RS13265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6J30_RS13270	COG2166	iron-sulfur cluster assembly
A6J30_RS13275	COG3706	GGDEF domain
A6J30_RS13280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J30_RS13285	COG0693	protein deglycase activity
A6J30_RS13290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6J30_RS13295	COG3248	Nucleoside-binding outer membrane protein
A6J30_RS13320	COG1595	DNA-templated transcription, initiation
A6J30_RS13340	COG3056	Lipoprotein
A6J30_RS13345	COG2813	Specifically methylates the guanine in position
A6J30_RS13350	COG0271	Belongs to the BolA IbaG family
A6J30_RS13360	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J30_RS13365	COG1805	sodium ion transport
A6J30_RS13370	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J30_RS13375	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J30_RS13380	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J30_RS13385	COG2871	sodium ion transport
A6J30_RS13390	COG1477	protein flavinylation
A6J30_RS13405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6J30_RS13410	COG0514	ATP-dependent DNA helicase (RecQ)
A6J30_RS13415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J30_RS13430	COG0733	neurotransmitter:sodium symporter activity
A6J30_RS13450	COG0442	prolyl-tRNA aminoacylation
A6J30_RS13455	COG1720	tRNA m6t6A37 methyltransferase activity
A6J30_RS13460	COG0254	rRNA binding
A6J30_RS13475	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6J30_RS13480	COG1671	Belongs to the UPF0178 family
A6J30_RS13505	COG3098	single-species biofilm formation
A6J30_RS13510	COG0564	pseudouridine synthase activity
A6J30_RS13520	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6J30_RS13525	COG0024	Methionine aminopeptidase
A6J30_RS13530	COG0052	Belongs to the universal ribosomal protein uS2 family
A6J30_RS13535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6J30_RS13540	COG0528	UMP kinase activity
A6J30_RS13545	COG0233	cytoplasmic translational termination
A6J30_RS13550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6J30_RS13555	COG0575	Belongs to the CDS family
A6J30_RS13560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6J30_RS13565	COG0750	zinc metalloprotease
A6J30_RS13575	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A6J30_RS13580	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J30_RS13585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J30_RS13590	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J30_RS13595	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J30_RS13600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6J30_RS13605	COG0587	DNA-directed DNA polymerase activity
A6J30_RS13610	COG0825	malonyl-CoA metabolic process
A6J30_RS13615	COG0037	tRNA processing
A6J30_RS13625	COG0347	Belongs to the P(II) protein family
A6J30_RS13630	COG3021	interspecies interaction between organisms
A6J30_RS13640	COG0741	lytic transglycosylase activity
A6J30_RS13640	COG1388	LysM domain
A6J30_RS13645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J30_RS13650	COG2226	methyltransferase
A6J30_RS13655	COG0328	RNA-DNA hybrid ribonuclease activity
A6J30_RS13660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J30_RS13675	COG1960	acyl-CoA dehydrogenase activity
A6J30_RS13680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6J30_RS13685	COG0121	glutamine amidotransferase
A6J30_RS13690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J30_RS13695	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6J30_RS13700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6J30_RS13705	COG2233	PERMEase
A6J30_RS13725	COG1393	Belongs to the ArsC family
A6J30_RS13730	COG4783	chaperone-mediated protein folding
A6J30_RS13745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6J30_RS13750	COG2716	regulation of RNA biosynthetic process
A6J30_RS13755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J30_RS13760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A6J30_RS13775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J30_RS13780	COG1393	Belongs to the ArsC family
A6J30_RS13810	COG2837	iron assimilation
A6J30_RS13815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J30_RS13825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J30_RS13830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J30_RS13835	COG1334	flagellar protein FlaG
A6J30_RS13840	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A6J30_RS13850	COG1516	flagellar protein fliS
A6J30_RS13870	COG1677	Flagellar hook-basal body complex protein FliE
A6J30_RS13880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6J30_RS13930	COG1987	bacterial-type flagellum assembly
A6J30_RS13935	COG1684	flagellar biosynthetic protein fliR
A6J30_RS13970	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A6J30_RS13975	COG2198	Histidine kinase
A6J30_RS13975	COG0643	Histidine kinase
A6J30_RS13975	COG0784	Response regulator, receiver
A6J30_RS13980	COG2201	protein-glutamate methylesterase activity
A6J30_RS13985	COG1192	Involved in chromosome partitioning
A6J30_RS13995	COG0835	chemotaxis
A6J30_RS14005	COG4133	protoheme IX ABC transporter activity
A6J30_RS14010	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J30_RS14015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J30_RS14020	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J30_RS14025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6J30_RS14030	COG1138	Cytochrome C-type biogenesis protein
A6J30_RS14035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J30_RS14050	COG2853	Lipoprotein
A6J30_RS14060	COG2067	long-chain fatty acid transport protein
A6J30_RS14080	COG0183	Belongs to the thiolase family
A6J30_RS14085	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J30_RS14085	COG1024	Enoyl-CoA hydratase
A6J30_RS14100	COG2062	phosphohistidine phosphatase, SixA
A6J30_RS14105	COG2840	Smr protein MutS2
A6J30_RS14110	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J30_RS14115	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6J30_RS14120	COG2860	membrane
A6J30_RS14130	COG3101	peptidyl-lysine hydroxylation
A6J30_RS14145	COG0431	NADPH-dependent FMN reductase
A6J30_RS14150	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6J30_RS14150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J30_RS14155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J30_RS14165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J30_RS14170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J30_RS14180	COG0101	tRNA pseudouridine synthase activity
A6J30_RS14185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6J30_RS14190	COG0285	dihydrofolate synthase activity
A6J30_RS14195	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6J30_RS14200	COG1286	toxin biosynthetic process
A6J30_RS14205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J30_RS14210	COG0583	DNA-binding transcription factor activity
A6J30_RS14215	COG0745	RESPONSE REGULATOR receiver
A6J30_RS14225	COG2832	Protein of unknown function (DUF454)
A6J30_RS14230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J30_RS14240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6J30_RS14245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6J30_RS14250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J30_RS14255	COG0814	amino acid
A6J30_RS14260	COG0251	oxidation-reduction process
A6J30_RS14265	COG3681	Belongs to the UPF0597 family
A6J30_RS14280	COG2261	transglycosylase associated protein
A6J30_RS14285	COG2983	Belongs to the UPF0260 family
A6J30_RS14290	COG0668	transmembrane transport
A6J30_RS14295	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A6J30_RS14300	COG0346	lactoylglutathione lyase activity
A6J30_RS14310	COG1785	Belongs to the alkaline phosphatase family
A6J30_RS14330	COG2226	methyltransferase
A6J30_RS14345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J30_RS14350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J30_RS14360	COG3139	Protein of unknown function (DUF1315)
A6J30_RS14365	COG0252	asparaginase activity
A6J30_RS14370	COG0616	signal peptide processing
A6J30_RS14375	COG1902	pentaerythritol trinitrate reductase activity
A6J30_RS14375	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J30_RS14380	COG0778	Nitroreductase
A6J30_RS14385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J30_RS14405	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6J30_RS14475	COG0582	viral genome integration into host DNA
A6J30_RS14485	COG3083	sulfuric ester hydrolase activity
A6J30_RS14490	COG3082	Protein of unknown function (DUF1414)
A6J30_RS14495	COG3081	Nucleoid-associated protein
A6J30_RS14510	COG1757	Na H antiporter
A6J30_RS14515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J30_RS14520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J30_RS14525	COG2095	MarC family integral membrane protein
A6J30_RS14530	COG1454	alcohol dehydrogenase
A6J30_RS14530	COG1012	belongs to the aldehyde dehydrogenase family
A6J30_RS14550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6J30_RS14560	COG2056	Na+-H+ antiporter family
A6J30_RS14565	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J30_RS14580	COG2885	chlorophyll binding
A6J30_RS14590	COG0346	lactoylglutathione lyase activity
A6J30_RS14595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J30_RS14600	COG4660	Part of a membrane complex involved in electron transport
A6J30_RS14605	COG4659	FMN binding
A6J30_RS14610	COG4658	electron transport chain
A6J30_RS14615	COG4656	Part of a membrane complex involved in electron transport
A6J30_RS14620	COG2878	Part of a membrane complex involved in electron transport
A6J30_RS14625	COG4657	Part of a membrane complex involved in electron transport
A6J30_RS14640	COG0556	nucleotide-excision repair
A6J30_RS14645	COG2204	response regulator
A6J30_RS14650	COG2198	Histidine kinase
A6J30_RS14655	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6J30_RS14660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6J30_RS14665	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6J30_RS14670	COG0315	cyclic pyranopterin monophosphate synthase activity
A6J30_RS14675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6J30_RS14680	COG0314	molybdopterin synthase activity
A6J30_RS14690	COG0601	transmembrane transport
A6J30_RS14695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J30_RS14700	COG0444	Belongs to the ABC transporter superfamily
A6J30_RS14710	COG0435	Glutathione S-transferase
A6J30_RS14720	COG3174	membrane
A6J30_RS14725	COG0280	phosphate acetyltransferase
A6J30_RS14725	COG0857	belongs to the CobB CobQ family
A6J30_RS14730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6J30_RS14735	COG3092	negative regulation of chromosome organization
A6J30_RS14745	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6J30_RS14750	COG1122	ATPase activity
A6J30_RS14755	COG0366	Alpha amylase catalytic
A6J30_RS14765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J30_RS14770	COG0653	protein targeting
A6J30_RS14775	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6J30_RS14780	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J30_RS14785	COG2186	Transcriptional regulator
A6J30_RS14795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J30_RS14795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J30_RS14800	COG0489	protein tyrosine kinase activity
A6J30_RS14805	COG0572	uridine kinase
A6J30_RS14815	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A6J30_RS14820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J30_RS14825	COG0659	secondary active sulfate transmembrane transporter activity
A6J30_RS14835	COG1530	ribonuclease E activity
A6J30_RS14850	COG0564	pseudouridine synthase activity
A6J30_RS14855	COG0424	maF-like protein
A6J30_RS14860	COG1399	metal-binding, possibly nucleic acid-binding protein
A6J30_RS14870	COG0416	fatty acid biosynthetic process
A6J30_RS14875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J30_RS14905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J30_RS14910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6J30_RS14920	COG0084	hydrolase, TatD family'
A6J30_RS14925	COG1263	PTS System
A6J30_RS14925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J30_RS14945	COG0733	neurotransmitter:sodium symporter activity
A6J30_RS14960	COG4667	esterase of the alpha-beta hydrolase superfamily
A6J30_RS14965	COG0469	pyruvate kinase activity
A6J30_RS14970	COG1940	carbohydrate kinase activity
A6J30_RS14975	COG0835	chemotaxis
A6J30_RS14975	COG0784	Response regulator, receiver
A6J30_RS14980	COG0587	DNA-directed DNA polymerase activity
A6J30_RS14995	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS15000	COG0616	signal peptide processing
A6J30_RS15005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6J30_RS15010	COG0539	negative regulation of cytoplasmic translation
A6J30_RS15020	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6J30_RS15025	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6J30_RS15030	COG0284	orotidine-5'-phosphate decarboxylase activity
A6J30_RS15035	COG4166	transmembrane transport
A6J30_RS15060	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A6J30_RS15070	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J30_RS15070	COG3008	intermembrane lipid transfer
A6J30_RS15075	COG2995	paraquat-inducible protein a
A6J30_RS15080	COG3258	Cytochrome c
A6J30_RS15085	COG2863	cytochrome
A6J30_RS15125	COG4232	protein-disulfide reductase activity
A6J30_RS15130	COG3118	belongs to the thioredoxin family
A6J30_RS15160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J30_RS15170	COG1136	(ABC) transporter
A6J30_RS15170	COG0577	efflux transmembrane transporter activity
A6J30_RS15175	COG1136	(ABC) transporter
A6J30_RS15175	COG0577	efflux transmembrane transporter activity
A6J30_RS15180	COG1136	(ABC) transporter
A6J30_RS15180	COG0577	efflux transmembrane transporter activity
A6J30_RS15185	COG1335	isochorismatase
A6J30_RS15190	COG1917	Cupin 2, conserved barrel domain protein
A6J30_RS15190	COG2207	Transcriptional regulator
A6J30_RS15235	COG5002	protein histidine kinase activity
A6J30_RS15235	COG3850	Histidine kinase
A6J30_RS15240	COG0745	RESPONSE REGULATOR receiver
A6J30_RS15250	COG0840	transmembrane signaling receptor activity
A6J30_RS15255	COG1032	radical SAM domain protein
A6J30_RS15260	COG4251	negative regulation of phosphorylation
A6J30_RS15260	COG3706	GGDEF domain
A6J30_RS15260	COG2203	Gaf domain
A6J30_RS15260	COG5001	Diguanylate cyclase
A6J30_RS15275	COG0583	DNA-binding transcription factor activity
A6J30_RS15285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6J30_RS15295	COG2350	Protein conserved in bacteria
A6J30_RS15305	COG2917	probably involved in intracellular septation
A6J30_RS15325	COG1301	dicarboxylic acid transport
A6J30_RS15335	COG0318	PFAM AMP-dependent synthetase and ligase
A6J30_RS15340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J30_RS15350	COG0159	tryptophan synthase activity
A6J30_RS15355	COG0133	tryptophan synthase activity
A6J30_RS15360	COG0135	phosphoribosylanthranilate isomerase activity
A6J30_RS15360	COG0134	indole-3-glycerol-phosphate synthase activity
A6J30_RS15365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6J30_RS15370	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J30_RS15375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J30_RS15385	COG0613	PHP domain protein
A6J30_RS15390	COG0009	L-threonylcarbamoyladenylate synthase
A6J30_RS15400	COG1187	pseudouridine synthase activity
A6J30_RS15410	COG3099	Belongs to the UPF0263 family
A6J30_RS15415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J30_RS15425	COG0417	DNA replication proofreading
A6J30_RS15430	COG2197	response regulator
A6J30_RS15435	COG0322	excinuclease ABC activity
A6J30_RS15475	COG0019	diaminopimelate decarboxylase activity
A6J30_RS15500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J30_RS15505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J30_RS15510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J30_RS15530	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A6J30_RS15540	COG0437	4 iron, 4 sulfur cluster binding
A6J30_RS15545	COG3301	Polysulphide reductase, NrfD
A6J30_RS15550	COG1138	Cytochrome C-type biogenesis protein
A6J30_RS15560	COG3088	subunit of a heme lyase
A6J30_RS15560	COG4235	cytochrome complex assembly
A6J30_RS15570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J30_RS15595	COG2989	Protein conserved in bacteria
A6J30_RS15600	COG3108	Peptidase M15
A6J30_RS15605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J30_RS15620	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A6J30_RS15645	COG1846	Transcriptional regulator
A6J30_RS15650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J30_RS15655	COG0840	transmembrane signaling receptor activity
A6J30_RS15675	COG1448	Aminotransferase
A6J30_RS15700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J30_RS15710	COG0017	Asparaginyl-tRNA synthetase
A6J30_RS15715	COG0840	transmembrane signaling receptor activity
A6J30_RS15730	COG0557	exoribonuclease II activity
A6J30_RS15735	COG1278	Cold shock
A6J30_RS15765	COG0720	synthase
A6J30_RS15775	COG2200	EAL domain
A6J30_RS15780	COG1760	l-serine dehydratase
A6J30_RS15785	COG0814	amino acid
A6J30_RS15790	COG0494	nUDIX hydrolase
A6J30_RS15800	COG0784	Response regulator, receiver
A6J30_RS15800	COG2205	protein histidine kinase activity
A6J30_RS15805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J30_RS15825	COG3106	COG3106 Predicted ATPase
A6J30_RS15830	COG3768	UPF0283 membrane protein
A6J30_RS15840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J30_RS15865	COG0346	lactoylglutathione lyase activity
A6J30_RS16145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J30_RS16185	COG2161	toxin-antitoxin pair type II binding
A6J30_RS16190	COG4115	mRNA cleavage
A6J30_RS16260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6J30_RS16300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J30_RS16385	COG0251	oxidation-reduction process
A6J30_RS16460	COG1757	Na H antiporter
A6J30_RS16465	COG0174	glutamine synthetase
A6J30_RS16475	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6J30_RS16480	COG1396	sequence-specific DNA binding
A6J30_RS16480	COG1917	Cupin 2, conserved barrel domain protein
A6J30_RS16485	COG1012	belongs to the aldehyde dehydrogenase family
A6J30_RS16490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J30_RS16500	COG2957	Belongs to the agmatine deiminase family
A6J30_RS16505	COG1012	belongs to the aldehyde dehydrogenase family
A6J30_RS16510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6J30_RS16515	COG1227	inorganic diphosphatase activity
A6J30_RS16525	COG2771	luxR family
A6J30_RS16525	COG2200	EAL domain
A6J30_RS16540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J30_RS16555	COG1846	Transcriptional regulator
A6J30_RS16560	COG2315	Protein conserved in bacteria
A6J30_RS16580	COG0110	maltose O-acetyltransferase activity
A6J30_RS16605	COG1289	transmembrane transporter activity
A6J30_RS16640	COG4771	TonB-dependent receptor
A6J30_RS16640	COG1629	transport
A6J30_RS16655	COG0789	Transcriptional regulator
A6J30_RS16660	COG4604	ABC transporter, ATP-binding protein
A6J30_RS16665	COG4605	iron ion homeostasis
A6J30_RS16670	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J30_RS16675	COG4607	ABC-type enterochelin transport system periplasmic component
A6J30_RS16700	COG2847	Copper chaperone PCu(A)C
A6J30_RS16705	COG0443	Heat shock 70 kDa protein
A6J30_RS16745	COG0625	glutathione transferase activity
A6J30_RS16760	COG4160	amino acid transport
A6J30_RS16765	COG4215	(ABC) transporter
A6J30_RS16770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J30_RS16775	COG1126	abc transporter atp-binding protein
A6J30_RS16785	COG1902	pentaerythritol trinitrate reductase activity
A6J30_RS16800	COG0109	protoheme IX farnesyltransferase activity
A6J30_RS16805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A6J30_RS16810	COG1845	cytochrome c oxidase, subunit III
A6J30_RS16815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6J30_RS16820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6J30_RS16825	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS16835	COG1024	Enoyl-CoA hydratase
A6J30_RS16840	COG1024	Enoyl-CoA hydratase
A6J30_RS16855	COG0183	Belongs to the thiolase family
A6J30_RS16865	COG1960	acyl-CoA dehydrogenase activity
A6J30_RS16870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6J30_RS16875	COG1024	Enoyl-CoA hydratase
A6J30_RS16885	COG5413	integral membrane protein
A6J30_RS16900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6J30_RS16910	COG5001	Diguanylate cyclase
A6J30_RS16915	COG0513	Belongs to the DEAD box helicase family
A6J30_RS16920	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A6J30_RS16935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6J30_RS16955	COG0641	radical SAM
A6J30_RS16980	COG0840	transmembrane signaling receptor activity
A6J30_RS16985	COG1119	ATPase activity
A6J30_RS16990	COG2200	EAL domain
A6J30_RS17010	COG0513	Belongs to the DEAD box helicase family
A6J30_RS17015	COG0523	cobalamin synthesis protein
A6J30_RS17025	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A6J30_RS17035	COG0133	tryptophan synthase activity
A6J30_RS17040	COG4628	conserved protein (DUF2132)
A6J30_RS17045	COG0513	Belongs to the DEAD box helicase family
A6J30_RS17050	COG3530	Putative quorum-sensing-regulated virulence factor
A6J30_RS17075	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6J30_RS17080	COG3186	Phenylalanine-4-hydroxylase
A6J30_RS17085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J30_RS17090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J30_RS17130	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A6J30_RS17135	COG1454	alcohol dehydrogenase
A6J30_RS17140	COG2133	pyrroloquinoline quinone binding
A6J30_RS17150	COG0783	Belongs to the Dps family
A6J30_RS17155	COG0840	transmembrane signaling receptor activity
A6J30_RS17165	COG0577	efflux transmembrane transporter activity
A6J30_RS17165	COG1136	(ABC) transporter
A6J30_RS17185	COG2199	diguanylate cyclase activity
A6J30_RS17200	COG3036	rescue of stalled ribosome
A6J30_RS17205	COG1278	Cold shock
A6J30_RS17240	COG0545	Peptidyl-prolyl cis-trans isomerase
A6J30_RS17245	COG0109	protoheme IX farnesyltransferase activity
A6J30_RS17250	COG1612	heme a metabolic process
A6J30_RS17275	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6J30_RS17285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6J30_RS17290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J30_RS17300	COG1280	lysine exporter protein (LysE YggA)
A6J30_RS17305	COG2207	Transcriptional regulator
A6J30_RS17330	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6J30_RS17335	COG0697	spore germination
A6J30_RS17360	COG2814	Major facilitator Superfamily
A6J30_RS17365	COG0583	DNA-binding transcription factor activity
A6J30_RS17370	COG5001	Diguanylate cyclase
A6J30_RS17375	COG0739	heme binding
A6J30_RS17400	COG3314	Sporulation integral membrane protein YlbJ
A6J30_RS17415	COG0814	amino acid
A6J30_RS17435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6J30_RS17440	COG1072	(Pantothenic acid kinase))
A6J30_RS17450	COG1063	alcohol dehydrogenase
A6J30_RS17455	COG2213	PTS system mannitol-specific
A6J30_RS17460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J30_RS17480	COG0798	PFAM Bile acid sodium symporter
A6J30_RS17490	COG1881	PFAM PEBP family protein
A6J30_RS17500	COG2706	6-phosphogluconolactonase activity
A6J30_RS17520	COG1131	(ABC) transporter
A6J30_RS17525	COG0842	Transport permease protein
A6J30_RS17540	COG3383	formate dehydrogenase (NAD+) activity
A6J30_RS17565	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J30_RS17595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J30_RS17605	COG2067	long-chain fatty acid transport protein
A6J30_RS17615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J30_RS17625	COG1505	serine-type exopeptidase activity
A6J30_RS17630	COG0488	(ABC) transporter
A6J30_RS17635	COG0589	response to stress
A6J30_RS17640	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J30_RS17660	COG0366	Alpha amylase catalytic
A6J30_RS17670	COG4934	collagen metabolic process
A6J30_RS17685	COG0583	DNA-binding transcription factor activity
A6J30_RS17695	COG0783	Belongs to the Dps family
A6J30_RS17700	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6J30_RS17775	COG0328	RNA-DNA hybrid ribonuclease activity
A6J30_RS17805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J30_RS17810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J30_RS17820	COG0835	chemotaxis
A6J30_RS17820	COG0784	Response regulator, receiver
A6J30_RS17830	COG0748	coenzyme F420 binding
A6J30_RS17835	COG3721	Heme iron utilization protein
A6J30_RS17845	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6J30_RS17850	COG0811	peptide transport
A6J30_RS17855	COG0848	biopolymer transport protein
A6J30_RS17865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J30_RS17870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6J30_RS17915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6J30_RS17920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6J30_RS17925	COG3217	Mosc domain protein beta barrel domain protein
A6J30_RS17925	COG3217	Mosc domain protein beta barrel domain protein
A6J30_RS17925	COG0633	Ferredoxin
A6J30_RS17925	COG0633	Ferredoxin
A6J30_RS17935	COG0401	homolog of Blt101
A6J30_RS17945	COG0418	dihydroorotase activity
A6J30_RS17950	COG2354	Protein conserved in bacteria
A6J30_RS17980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J30_RS17980	COG2207	Transcriptional regulator
A6J30_RS17985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J30_RS18030	COG0513	Belongs to the DEAD box helicase family
A6J30_RS18040	COG0583	DNA-binding transcription factor activity
A6J30_RS18055	COG1902	pentaerythritol trinitrate reductase activity
A6J30_RS18060	COG1063	alcohol dehydrogenase
A6J30_RS18070	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS18085	COG3122	Protein conserved in bacteria
A6J30_RS18100	COG0583	DNA-binding transcription factor activity
A6J30_RS18105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6J30_RS18110	COG0252	asparaginase activity
A6J30_RS18115	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6J30_RS18120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J30_RS18120	COG0574	Belongs to the PEP-utilizing enzyme family
A6J30_RS18140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J30_RS18160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J30_RS18180	COG3706	GGDEF domain
A6J30_RS18200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J30_RS18230	COG3842	ATPase activity
A6J30_RS18275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J30_RS18325	COG0583	DNA-binding transcription factor activity
A6J30_RS18335	COG4948	Mandelate Racemase Muconate Lactonizing
A6J30_RS18370	COG1342	Belongs to the UPF0251 family
A6J30_RS18380	COG3015	lipoprotein NlpE involved in copper resistance
A6J30_RS18390	COG3713	MltA-interacting MipA family protein
A6J30_RS18405	COG0583	DNA-binding transcription factor activity
A6J30_RS18435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6J30_RS18445	COG1335	isochorismatase
A6J30_RS18455	COG0753	catalase activity
A6J30_RS18465	COG1349	DNA-binding transcription factor activity
A6J30_RS18470	COG0346	lactoylglutathione lyase activity
A6J30_RS18485	COG0583	DNA-binding transcription factor activity
A6J30_RS18495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J30_RS18500	COG2070	2-Nitropropane dioxygenase
A6J30_RS18505	COG0737	Belongs to the 5'-nucleotidase family
A6J30_RS18515	COG1309	transcriptional regulator
A6J30_RS18535	COG1280	lysine exporter protein (LysE YggA)
A6J30_RS18550	COG0459	protein refolding
A6J30_RS18555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6J30_RS18565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J30_RS18595	COG1304	FMN binding
A6J30_RS18615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J30_RS18620	COG1256	bacterial-type flagellum assembly
A6J30_RS18620	COG4786	Flagellar basal body rod
A6J30_RS18630	COG1706	bacterial-type flagellum-dependent cell motility
A6J30_RS18635	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6J30_RS18640	COG4786	Flagellar basal body rod
A6J30_RS18645	COG4787	bacterial-type flagellum-dependent cell motility
A6J30_RS18650	COG1749	Flagellar hook protein flgE
A6J30_RS18655	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6J30_RS18660	COG1558	bacterial-type flagellum-dependent cell motility
A6J30_RS18665	COG1815	bacterial-type flagellum-dependent cell motility
A6J30_RS18685	COG0741	lytic transglycosylase activity
A6J30_RS18695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6J30_RS18715	COG1760	l-serine dehydratase
A6J30_RS18720	COG3104	oligopeptide transport
A6J30_RS18740	COG0583	DNA-binding transcription factor activity
A6J30_RS18755	COG2866	Carboxypeptidase
A6J30_RS18760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J30_RS18770	COG2990	Protein conserved in bacteria
A6J30_RS18795	COG3842	ATPase activity
A6J30_RS18805	COG1840	ABC-type Fe3 transport system, periplasmic component
A6J30_RS18810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6J30_RS18815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6J30_RS18820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J30_RS18825	COG1609	Transcriptional regulator
A6J30_RS18855	COG3240	lipase activity
A6J30_RS18865	COG0577	efflux transmembrane transporter activity
A6J30_RS18865	COG1136	(ABC) transporter
A6J30_RS18870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J30_RS18875	COG2067	long-chain fatty acid transport protein
A6J30_RS18885	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6J30_RS18900	COG1011	Hydrolase
A6J30_RS18940	COG0110	maltose O-acetyltransferase activity
A6J30_RS18945	COG1765	OsmC-like protein
A6J30_RS18950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J30_RS18950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J30_RS18965	COG3046	protein related to deoxyribodipyrimidine photolyase
A6J30_RS18970	COG0415	Belongs to the DNA photolyase family
A6J30_RS18975	COG3706	GGDEF domain
A6J30_RS18990	COG0840	transmembrane signaling receptor activity
A6J30_RS18995	COG3706	GGDEF domain
A6J30_RS19010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J30_RS19030	COG3033	Beta-eliminating lyase
A6J30_RS19040	COG0579	oxidoreductase
A6J30_RS19065	COG1114	Component of the transport system for branched-chain amino acids
A6J30_RS19070	COG3706	GGDEF domain
A6J30_RS19115	COG0583	DNA-binding transcription factor activity
A6J30_RS19125	COG0189	ligase activity
A6J30_RS19130	COG0189	ligase activity
A6J30_RS19130	COG4067	protein conserved in archaea
A6J30_RS19140	COG1166	arginine decarboxylase activity
A6J30_RS19145	COG0010	Belongs to the arginase family
A6J30_RS19150	COG2814	Major facilitator Superfamily
A6J30_RS19155	COG1770	oligopeptidase
A6J30_RS19170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J30_RS19175	COG1121	(ABC) transporter
A6J30_RS19180	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J30_RS19220	COG0848	biopolymer transport protein
A6J30_RS19225	COG0811	peptide transport
A6J30_RS19230	COG0811	peptide transport
A6J30_RS19250	COG0745	RESPONSE REGULATOR receiver
A6J30_RS19255	COG0039	L-malate dehydrogenase activity
A6J30_RS19260	COG0584	glycerophosphoryl diester phosphodiesterase
A6J30_RS19270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J30_RS19330	COG1901	pseudouridine methyltransferase
A6J30_RS19335	COG0312	modulator of DNA gyrase
A6J30_RS19340	COG0312	modulator of DNA gyrase
A6J30_RS19350	COG0351	phosphomethylpyrimidine kinase
A6J30_RS19355	COG1116	anion transmembrane transporter activity
A6J30_RS19360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J30_RS19365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J30_RS19370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6J30_RS19375	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A6J30_RS19380	COG0352	thiamine-phosphate diphosphorylase activity
A6J30_RS19390	COG0243	molybdopterin cofactor binding
A6J30_RS19395	COG3005	denitrification pathway
A6J30_RS19405	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS19420	COG0456	acetyltransferase
A6J30_RS19440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J30_RS19445	COG1929	Belongs to the glycerate kinase type-1 family
A6J30_RS19450	COG2610	gluconate transmembrane transporter activity
A6J30_RS19455	COG3835	regulator
A6J30_RS19480	COG0546	phosphoglycolate phosphatase activity
A6J30_RS19495	COG0583	DNA-binding transcription factor activity
A6J30_RS19505	COG0583	DNA-binding transcription factor activity
A6J30_RS19515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A6J30_RS19520	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A6J30_RS19520	COG3408	Glycogen debranching enzyme
A6J30_RS19550	COG3047	cAMP biosynthetic process
A6J30_RS19555	COG1357	PFAM Pentapeptide repeats (8 copies)
A6J30_RS19585	COG2375	cellular response to nickel ion
A6J30_RS19590	COG0823	Involved in the tonB-independent uptake of proteins
A6J30_RS19595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J30_RS19615	COG0800	Aldolase
A6J30_RS19620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J30_RS19635	COG1917	Cupin 2, conserved barrel domain protein
A6J30_RS19645	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS19650	COG1414	Transcriptional regulator
A6J30_RS19665	COG0583	DNA-binding transcription factor activity
A6J30_RS19670	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A6J30_RS19675	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A6J30_RS19690	COG2199	diguanylate cyclase activity
A6J30_RS19700	COG0561	phosphatase activity
A6J30_RS19705	COG0583	DNA-binding transcription factor activity
A6J30_RS19720	COG0564	pseudouridine synthase activity
A6J30_RS19725	COG0534	Mate efflux family protein
A6J30_RS19735	COG5001	Diguanylate cyclase
A6J30_RS19745	COG3123	guanosine phosphorylase activity
A6J30_RS19785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J30_RS19795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J30_RS19800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A6J30_RS19815	COG2259	Doxx family
A6J30_RS19820	COG1741	Belongs to the pirin family
A6J30_RS19840	COG0363	glucosamine-6-phosphate deaminase activity
A6J30_RS19855	COG0786	glutamate:sodium symporter activity
A6J30_RS19860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J30_RS19865	COG1131	(ABC) transporter
A6J30_RS19875	COG0786	glutamate:sodium symporter activity
A6J30_RS19910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J30_RS19920	COG3279	Response regulator of the LytR AlgR family
A6J30_RS19925	COG3275	phosphorelay sensor kinase activity
A6J30_RS19945	COG1136	(ABC) transporter
A6J30_RS19960	COG0772	Belongs to the SEDS family
A6J30_RS19965	COG0217	transcriptional regulatory protein
A6J30_RS19990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J30_RS19990	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
A6J30_RS20000	COG0444	Belongs to the ABC transporter superfamily
A6J30_RS20005	COG4608	Belongs to the ABC transporter superfamily
A6J30_RS20035	COG1444	tRNA N-acetyltransferase activity
A6J30_RS20055	COG3340	Belongs to the peptidase S51 family
A6J30_RS20060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6J30_RS20065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J30_RS20065	COG1263	PTS System
A6J30_RS20070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6J30_RS20090	COG4166	transmembrane transport
A6J30_RS20135	COG0259	pyridoxamine-phosphate oxidase activity
A6J30_RS20165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J30_RS20210	COG1132	(ABC) transporter
A6J30_RS20220	COG2207	Transcriptional regulator
A6J30_RS20245	COG0800	Aldolase
A6J30_RS20250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J30_RS20255	COG1904	glucuronate isomerase
A6J30_RS20260	COG0246	Mannitol dehydrogenase
A6J30_RS20270	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6J30_RS20280	COG2186	Transcriptional regulator
A6J30_RS20285	COG1312	Catalyzes the dehydration of D-mannonate
A6J30_RS20290	COG0513	Belongs to the DEAD box helicase family
A6J30_RS20295	COG2258	MOSC domain
A6J30_RS20310	COG1486	melibiose metabolic process
A6J30_RS20315	COG0583	DNA-binding transcription factor activity
A6J30_RS20335	COG1595	DNA-templated transcription, initiation
A6J30_RS20370	COG3634	alkyl hydroperoxide reductase activity
A6J30_RS20380	COG1846	Transcriptional regulator
A6J30_RS20385	COG1764	response to oxidative stress
A6J30_RS20410	COG2160	L-arabinose isomerase activity
A6J30_RS20420	COG1069	ribulokinase activity
A6J30_RS20425	COG1879	ABC-type sugar transport system periplasmic component
A6J30_RS20430	COG1129	ABC transporter
A6J30_RS20435	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J30_RS20440	COG0826	peptidase U32
A6J30_RS20465	COG0642	Histidine kinase
A6J30_RS20470	COG1653	transport
A6J30_RS20475	COG0019	diaminopimelate decarboxylase activity
A6J30_RS20480	COG4264	IucA IucC family
A6J30_RS20505	COG4772	TonB-dependent receptor
A6J30_RS20510	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A6J30_RS20515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J30_RS20520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J30_RS20525	COG1120	ATPase activity
A6J30_RS20530	COG0840	transmembrane signaling receptor activity
A6J30_RS20535	COG0612	Peptidase, M16
A6J30_RS20545	COG0739	heme binding
A6J30_RS20570	COG4580	involved in the transport of maltose and maltodextrins
A6J30_RS20595	COG2356	endonuclease I
A6J30_RS20615	COG1982	Orn Lys Arg decarboxylase major
A6J30_RS20620	COG0531	amino acid
A6J30_RS20630	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A6J30_RS20640	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6J30_RS20645	COG1162	GTPase activity
A6J30_RS20650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J30_RS20650	COG1263	PTS System
A6J30_RS20660	COG1999	signal sequence binding
A6J30_RS20675	COG2909	trisaccharide binding
A6J30_RS20690	COG0058	SHG alpha-glucan phosphorylase activity
A6J30_RS20695	COG1640	4-alpha-glucanotransferase
A6J30_RS20700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6J30_RS20705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J30_RS20710	COG0366	Alpha amylase catalytic
A6J30_RS20725	COG3366	ferrous iron transmembrane transporter activity
A6J30_RS20730	COG0700	Nucleoside recognition
A6J30_RS20735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J30_RS20740	COG3339	Conserved Protein
A6J30_RS20745	COG1301	dicarboxylic acid transport
A6J30_RS20755	COG0583	DNA-binding transcription factor activity
A6J30_RS20770	COG0489	protein tyrosine kinase activity
A6J30_RS20770	COG3206	protein involved in exopolysaccharide biosynthesis
A6J30_RS20790	COG2095	MarC family integral membrane protein
A6J30_RS20795	COG4667	esterase of the alpha-beta hydrolase superfamily
A6J30_RS20800	COG3397	chitin binding
A6J30_RS20805	COG1054	Belongs to the UPF0176 family
A6J30_RS20820	COG1686	Belongs to the peptidase S11 family
A6J30_RS20845	COG0583	DNA-binding transcription factor activity
A6J30_RS20850	COG4628	conserved protein (DUF2132)
A6J30_RS20860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J30_RS20870	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A6J30_RS20875	COG0628	permease
A6J30_RS20920	COG2814	Major facilitator Superfamily
A6J30_RS20935	COG0454	-acetyltransferase
A6J30_RS20945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6J30_RS20950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J30_RS20955	COG1882	Formate acetyltransferase
A6J30_RS21005	COG1360	Flagellar Motor Protein
A6J30_RS21010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6J30_RS21015	COG1191	sigma factor activity
A6J30_RS21020	COG1580	Controls the rotational direction of flagella during chemotaxis
A6J30_RS21035	COG1516	flagellar protein fliS
A6J30_RS21040	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A6J30_RS21050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J30_RS21065	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6J30_RS21075	COG1987	bacterial-type flagellum assembly
A6J30_RS21155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6J30_RS21175	COG0346	lactoylglutathione lyase activity
A6J30_RS21210	COG0745	RESPONSE REGULATOR receiver
A6J30_RS21230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J30_RS21240	COG0156	8-amino-7-oxononanoate synthase activity
A6J30_RS21245	COG1063	alcohol dehydrogenase
A6J30_RS21285	COG0668	transmembrane transport
A6J30_RS21295	COG1304	FMN binding
A6J30_RS21300	COG1620	l-lactate permease
A6J30_RS21305	COG0583	DNA-binding transcription factor activity
A6J30_RS21310	COG1505	serine-type exopeptidase activity
A6J30_RS21315	COG4172	Belongs to the ABC transporter superfamily
A6J30_RS21325	COG1067	ATP-dependent peptidase activity
A6J30_RS21355	COG1247	-acetyltransferase
A6J30_RS21360	COG0437	4 iron, 4 sulfur cluster binding
A6J30_RS21365	COG0348	domain, Protein
A6J30_RS21380	COG1122	ATPase activity
A6J30_RS21385	COG4720	Psort location CytoplasmicMembrane, score
A6J30_RS21390	COG1566	PFAM secretion protein HlyD family protein
A6J30_RS21400	COG3706	GGDEF domain
A6J30_RS21415	COG0813	purine-nucleoside phosphorylase activity
A6J30_RS21425	COG3272	Protein of unknown function (DUF1722)
A6J30_RS21430	COG0789	Transcriptional regulator
A6J30_RS21435	COG0415	Belongs to the DNA photolyase family
A6J30_RS21440	COG1376	ErfK ybiS ycfS ynhG family protein
A6J30_RS21440	COG1388	LysM domain
A6J30_RS21450	COG0513	Belongs to the DEAD box helicase family
A6J30_RS21455	COG1770	oligopeptidase
A6J30_RS21460	COG4771	TonB-dependent receptor
A6J30_RS21490	COG0573	inorganic phosphate transmembrane transporter activity
A6J30_RS21495	COG0581	inorganic phosphate transmembrane transporter activity
A6J30_RS21500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J30_RS21515	COG2304	oxidoreductase activity
A6J30_RS21535	COG0714	Associated with various cellular activities
A6J30_RS21545	COG0840	transmembrane signaling receptor activity
A6J30_RS21555	COG2197	response regulator
A6J30_RS21605	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A6J30_RS21610	COG1120	ATPase activity
A6J30_RS21615	COG4774	siderophore transport
A6J30_RS21620	COG1132	(ABC) transporter
A6J30_RS21625	COG2205	protein histidine kinase activity
A6J30_RS21635	COG0569	domain protein
A6J30_RS21640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J30_RS21650	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
A6J30_RS21655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J30_RS21670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J30_RS21670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J30_RS21670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J30_RS21675	COG2207	Transcriptional regulator
A6J30_RS21685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J30_RS21690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J30_RS21695	COG2084	Dehydrogenase
A6J30_RS21700	COG0753	catalase activity
A6J30_RS21710	COG2130	NADP-dependent
A6J30_RS21715	COG1309	transcriptional regulator
A6J30_RS21720	COG3097	Belongs to the UPF0267 family
A6J30_RS21780	COG3842	ATPase activity
A6J30_RS21790	COG1175	transmembrane transport
A6J30_RS21795	COG3833	ABC-type maltose transport systems, permease component
A6J30_RS21920	COG3064	Membrane
A6J30_RS22035	COG4789	Type iii secretion
A6J30_RS22040	COG4792	protein secretion
A6J30_RS22070	COG3710	Transcriptional regulator
A6J30_RS22105	COG4790	Type iii secretion
A6J30_RS22210	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6J30_RS22315	COG3746	phosphate-selective porin O and P
A6J30_RS22335	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS22360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6J30_RS22370	COG0625	glutathione transferase activity
A6J30_RS22385	COG1686	Belongs to the peptidase S11 family
A6J30_RS22405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6J30_RS22425	COG1278	Cold shock
A6J30_RS22435	COG4667	esterase of the alpha-beta hydrolase superfamily
A6J30_RS22460	COG2814	Major facilitator Superfamily
A6J30_RS22470	COG0673	inositol 2-dehydrogenase activity
A6J30_RS22475	COG2194	sulfuric ester hydrolase activity
A6J30_RS22480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6J30_RS22490	COG2205	protein histidine kinase activity
A6J30_RS22495	COG0745	RESPONSE REGULATOR receiver
A6J30_RS22500	COG4221	oxidoreductase activity
A6J30_RS22520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J30_RS22545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J30_RS22635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J30_RS22645	COG2814	Major facilitator Superfamily
A6J30_RS22660	COG1418	mRNA catabolic process
A6J30_RS22670	COG0402	S-adenosylhomocysteine deaminase activity
A6J30_RS22675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A6J30_RS22685	COG2239	Acts as a magnesium transporter
A6J30_RS22690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6J30_RS22705	COG0531	amino acid
A6J30_RS22715	COG1522	sequence-specific DNA binding
A6J30_RS22720	COG0583	DNA-binding transcription factor activity
A6J30_RS22740	COG2205	protein histidine kinase activity
A6J30_RS22740	COG0784	Response regulator, receiver
A6J30_RS22740	COG5002	protein histidine kinase activity
A6J30_RS22745	COG0673	inositol 2-dehydrogenase activity
A6J30_RS22750	COG0534	Mate efflux family protein
A6J30_RS22755	COG2926	Belongs to the UPF0265 family
A6J30_RS22770	COG3132	Protein of unknown function, DUF480
A6J30_RS22775	COG2827	Endonuclease containing a URI domain
A6J30_RS22780	COG1879	ABC-type sugar transport system periplasmic component
A6J30_RS22785	COG2205	protein histidine kinase activity
A6J30_RS22785	COG0784	Response regulator, receiver
A6J30_RS22795	COG1566	PFAM secretion protein HlyD family protein
A6J30_RS22815	COG1522	sequence-specific DNA binding
A6J30_RS22845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J30_RS22850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J30_RS22860	COG1280	lysine exporter protein (LysE YggA)
A6J30_RS22870	COG0183	Belongs to the thiolase family
A6J30_RS22890	COG3005	denitrification pathway
A6J30_RS22900	COG0243	molybdopterin cofactor binding
A6J30_RS22910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J30_RS22915	COG3850	Histidine kinase
A6J30_RS22920	COG2197	response regulator
A6J30_RS22935	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J30_RS22955	COG0840	transmembrane signaling receptor activity
A6J30_RS22965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J30_RS22980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J30_RS22985	COG2814	Major facilitator Superfamily
A6J30_RS22995	COG0840	transmembrane signaling receptor activity
A6J30_RS23000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6J30_RS23005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6J30_RS23035	COG2897	thiosulfate sulfurtransferase activity
A6J30_RS23055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J30_RS23065	COG0302	gtp cyclohydrolase
A6J30_RS23070	COG1914	H( )-stimulated, divalent metal cation uptake system
A6J30_RS23080	COG0038	chloride channel
A6J30_RS23095	COG4989	oxidoreductase activity
A6J30_RS23110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6J30_RS23110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6J30_RS23115	COG0516	GMP reductase activity
A6J30_RS23120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J30_RS23190	COG3474	cytochrome
A6J30_RS23200	COG0789	Transcriptional regulator
A6J30_RS23205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6J30_RS23210	COG0384	phenazine biosynthesis protein PhzF
A6J30_RS23220	COG1294	oxidase, subunit
A6J30_RS23225	COG1271	oxidase subunit
A6J30_RS23230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J30_RS23235	COG0110	maltose O-acetyltransferase activity
A6J30_RS23245	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6J30_RS23245	COG3264	Mechanosensitive ion channel
A6J30_RS23260	COG4999	Histidine kinase
A6J30_RS23260	COG2205	protein histidine kinase activity
A6J30_RS23260	COG3850	Histidine kinase
A6J30_RS23260	COG3437	response regulator, receiver
A6J30_RS23280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6J30_RS23285	COG1960	acyl-CoA dehydrogenase activity
A6J30_RS23295	COG0183	Belongs to the thiolase family
A6J30_RS23305	COG1960	acyl-CoA dehydrogenase activity
A6J30_RS23310	COG1024	Enoyl-CoA hydratase
A6J30_RS23325	COG1028	Short-chain dehydrogenase reductase Sdr
A6J30_RS23335	COG3706	GGDEF domain
A6J30_RS23340	COG1309	transcriptional regulator
A6J30_RS23345	COG1012	belongs to the aldehyde dehydrogenase family
A6J30_RS23360	COG4176	ABC-type proline glycine betaine transport system permease component
A6J30_RS23365	COG0517	IMP dehydrogenase activity
A6J30_RS23365	COG4175	Glycine betaine
A6J30_RS23380	COG0330	HflC and HflK could
A6J30_RS23390	COG3300	MHYT domain
A6J30_RS23390	COG5001	Diguanylate cyclase
A6J30_RS23410	COG2205	protein histidine kinase activity
A6J30_RS23410	COG0784	Response regulator, receiver
A6J30_RS23470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J30_RS23475	COG5001	Diguanylate cyclase
A6J30_RS23480	COG1869	D-ribose catabolic process
A6J30_RS23485	COG1129	ABC transporter
A6J30_RS23490	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J30_RS23495	COG1879	ABC-type sugar transport system periplasmic component
A6J30_RS23500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J30_RS23505	COG1609	Transcriptional regulator
A6J30_RS23520	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6J30_RS23540	COG0745	RESPONSE REGULATOR receiver
A6J30_RS23555	COG1785	Belongs to the alkaline phosphatase family
A6J30_RS23585	COG0814	amino acid
A6J30_RS23595	COG0243	molybdopterin cofactor binding
A6J30_RS23600	COG1648	precorrin-2 dehydrogenase activity
A6J30_RS23600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6J30_RS23620	COG3707	response regulator
A6J30_RS23630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J30_RS23635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J30_RS23640	COG1116	anion transmembrane transporter activity
A6J30_RS23645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6J30_RS23645	COG2146	nitrite reductase [NAD(P)H] activity
A6J30_RS23700	COG0515	serine threonine protein kinase
A6J30_RS23700	COG2815	serine threonine protein kinase
A6J30_RS23740	COG0631	protein serine/threonine phosphatase activity
A6J30_RS23810	COG0420	3'-5' exonuclease activity
A6J30_RS23815	COG0419	ATPase involved in DNA repair
A6J30_RS23835	COG3040	lipid binding
A6J30_RS23845	COG2814	Major facilitator Superfamily
A6J30_RS23855	COG1288	antiporter activity
A6J30_RS23870	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A6J30_RS23885	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A6J30_RS23905	COG0583	DNA-binding transcription factor activity
A6J30_RS23910	COG0277	FAD linked oxidase domain protein
A6J30_RS23930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J30_RS23975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J30_RS23975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J30_RS24025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J30_RS24030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6J30_RS24040	COG2116	formate transmembrane transporter activity
A6J30_RS24060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6J30_RS24095	COG0534	Mate efflux family protein
A6J30_RS24100	COG0745	RESPONSE REGULATOR receiver
A6J30_RS24100	COG2205	protein histidine kinase activity
A6J30_RS24100	COG3292	Two component regulator propeller
A6J30_RS24110	COG3118	belongs to the thioredoxin family
A6J30_RS24115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J30_RS24140	COG2271	Major facilitator Superfamily
A6J30_RS24145	COG3851	Histidine kinase
A6J30_RS24150	COG2197	response regulator
A6J30_RS24160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6J30_RS24165	COG0583	DNA-binding transcription factor activity
A6J30_RS24175	COG0243	molybdopterin cofactor binding
A6J30_RS24255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J30_RS24270	COG1328	CTP reductase activity
A6J30_RS24275	COG0602	queuosine metabolic process
A6J30_RS24280	COG0534	Mate efflux family protein
A6J30_RS24300	COG0189	ligase activity
A6J30_RS24300	COG4067	protein conserved in archaea
A6J30_RS24310	COG3111	PFAM Bacterial OB fold (BOF) protein
A6J30_RS24315	COG1492	cobalamin metabolic process
A6J30_RS24320	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6J30_RS24325	COG4149	molybdate abc transporter
A6J30_RS24330	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6J30_RS24340	COG5001	Diguanylate cyclase
A6J30_RS24340	COG4251	negative regulation of phosphorylation
A6J30_RS24340	COG3706	GGDEF domain
A6J30_RS24340	COG2203	Gaf domain
A6J30_RS24365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6J30_RS24370	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6J30_RS24395	COG3140	Belongs to the UPF0181 family
A6J30_RS24400	COG0589	response to stress
A6J30_RS24410	COG0583	DNA-binding transcription factor activity
A6J30_RS24555	COG0023	Translation Initiation Factor
A6J30_RS24565	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6J30_RS24575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J30_RS24575	COG1042	CoA-binding domain protein
A6J30_RS24575	COG0045	succinate-CoA ligase (ADP-forming) activity
A6J30_RS24580	COG0583	DNA-binding transcription factor activity
A6J30_RS24585	COG4771	TonB-dependent receptor
A6J30_RS24585	COG1629	transport
A6J30_RS24595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J30_RS24600	COG3447	MASE1 domain protein
A6J30_RS24600	COG5001	Diguanylate cyclase
A6J30_RS24600	COG5002	protein histidine kinase activity
A6J30_RS24605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6J30_RS24610	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A6J30_RS24615	COG1984	allophanate hydrolase subunit 2
A6J30_RS24620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J30_RS24620	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6J30_RS24625	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A6J30_RS24630	COG4181	ATPase activity
A6J30_RS24640	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6J30_RS24645	COG5001	Diguanylate cyclase
A6J30_RS24645	COG3300	MHYT domain
A6J30_RS24655	COG0484	heat shock protein binding
A6J30_RS24690	COG2050	protein possibly involved in aromatic compounds catabolism
A6J30_RS24705	COG2067	long-chain fatty acid transport protein
A6J30_RS24710	COG2267	carboxylic ester hydrolase activity
A6J30_RS24725	COG0861	Integral membrane protein TerC family
A6J30_RS24730	COG0737	Belongs to the 5'-nucleotidase family
A6J30_RS24735	COG3593	DNA synthesis involved in DNA repair
A6J30_RS24745	COG0583	DNA-binding transcription factor activity
A6J30_RS24750	COG2116	formate transmembrane transporter activity
A6J30_RS24755	COG2353	YceI-like domain
A6J30_RS24760	COG3038	cytochrome b561
A6J30_RS24775	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6J30_RS24780	COG0513	Belongs to the DEAD box helicase family
A6J30_RS24785	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A6J30_RS24795	COG0840	transmembrane signaling receptor activity
A6J30_RS24805	COG0546	phosphoglycolate phosphatase activity
A6J30_RS24815	COG3437	response regulator, receiver
A6J30_RS24815	COG0784	Response regulator, receiver
A6J30_RS24835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J30_RS24840	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6J30_RS24845	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J30_RS24860	COG2207	Transcriptional regulator
A6J30_RS24865	COG1979	alcohol dehydrogenase
A6J30_RS24890	COG2271	Major facilitator Superfamily
A6J30_RS24895	COG0469	pyruvate kinase activity
A6J30_RS24900	COG1126	abc transporter atp-binding protein
A6J30_RS24905	COG0765	amino acid transport
A6J30_RS24910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J30_RS24915	COG0765	amino acid transport
A6J30_RS24920	COG2203	Gaf domain
A6J30_RS24920	COG2199	diguanylate cyclase activity
A6J30_RS24920	COG2200	EAL domain
A6J30_RS24940	COG1609	Transcriptional regulator
A6J30_RS24945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J30_RS24945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J30_RS24950	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J30_RS24955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J30_RS24955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J30_RS24955	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A6J30_RS24975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J30_RS24995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6J30_RS25000	COG0509	glycine decarboxylation via glycine cleavage system
A6J30_RS25005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6J30_RS25005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6J30_RS25030	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A6J30_RS25035	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6J30_RS25040	COG0583	DNA-binding transcription factor activity
A6J30_RS25045	COG2176	DNA-directed DNA polymerase activity
A6J30_RS25090	COG0242	peptide deformylase activity
A6J30_RS25120	COG2239	Acts as a magnesium transporter
A6J30_RS25140	COG0346	lactoylglutathione lyase activity
A6J30_RS25145	COG1902	pentaerythritol trinitrate reductase activity
A6J30_RS25165	COG5642	Protein of unknown function (DUF2384)
A6J30_RS25170	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6J30_RS25190	COG4565	transcriptional regulatory protein
A6J30_RS25195	COG3290	protein histidine kinase activity
A6J30_RS25200	COG0471	metal ion transport
A6J30_RS25230	COG2076	Multidrug Resistance protein
A6J30_RS25245	COG0671	phosphoesterase, PA-phosphatase related
A6J30_RS25260	COG2962	Rard protein
A6J30_RS25275	COG2165	general secretion pathway protein
A6J30_RS25280	COG0835	chemotaxis
A6J30_RS25280	COG0784	Response regulator, receiver
A6J30_RS25305	COG2197	response regulator
A6J30_RS25315	COG3706	GGDEF domain
A6J30_RS25320	COG2197	response regulator
A6J30_RS25325	COG5001	Diguanylate cyclase
A6J30_RS25325	COG3300	MHYT domain
A6J30_RS25340	COG0583	DNA-binding transcription factor activity
A6J30_RS25345	COG0583	DNA-binding transcription factor activity
A6J30_RS25405	COG4964	Belongs to the GSP D family
A6J30_RS25430	COG2207	Transcriptional regulator
A6J30_RS25450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6J30_RS25470	COG0456	acetyltransferase
A6J30_RS25470	COG1214	PFAM Peptidase M22, glycoprotease
A6J30_RS25480	COG3069	C4-dicarboxylate transmembrane transporter activity
A6J30_RS25485	COG1704	LemA family
A6J30_RS25490	COG0501	Belongs to the peptidase M48B family
A6J30_RS25520	COG0641	radical SAM
A6J30_RS25540	COG3111	PFAM Bacterial OB fold (BOF) protein
A6J30_RS25545	COG1597	lipid kinase activity
A6J30_RS25550	COG0583	DNA-binding transcription factor activity
A6J30_RS25555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J30_RS25555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J30_RS25585	COG0714	Associated with various cellular activities
A6J30_RS25590	COG0641	radical SAM
A6J30_RS25595	COG3119	arylsulfatase activity
A6J30_RS25610	COG3119	arylsulfatase activity
A6J30_RS25615	COG3119	arylsulfatase activity
A6J30_RS25625	COG0745	RESPONSE REGULATOR receiver
A6J30_RS25640	COG2198	Histidine kinase
A6J30_RS25640	COG2205	protein histidine kinase activity
A6J30_RS25640	COG0784	Response regulator, receiver
A6J30_RS25645	COG1879	ABC-type sugar transport system periplasmic component
A6J30_RS25650	COG1803	Methylglyoxal synthase