locus-tag	class	description
FORC4_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC4_RS00020	COG1395	domain, Protein
FORC4_RS00105	COG4974	Belongs to the 'phage' integrase family
FORC4_RS00110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC4_RS00115	COG0706	membrane insertase activity
FORC4_RS00120	COG0594	ribonuclease P activity
FORC4_RS00130	COG1126	abc transporter atp-binding protein
FORC4_RS00145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC4_RS00150	COG0592	DNA-directed DNA polymerase activity
FORC4_RS00155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC4_RS00160	COG0187	DNA topoisomerase II activity
FORC4_RS00170	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC4_RS00175	COG3977	Valine--pyruvate aminotransferase
FORC4_RS00180	COG0366	Alpha amylase catalytic
FORC4_RS00185	COG0751	glycine-tRNA ligase activity
FORC4_RS00190	COG0752	glycyl-tRNA synthetase alpha subunit
FORC4_RS00195	COG2119	membrane
FORC4_RS00205	COG0425	Belongs to the sulfur carrier protein TusA family
FORC4_RS00220	COG0604	alcohol dehydrogenase
FORC4_RS00225	COG0183	Belongs to the thiolase family
FORC4_RS00230	COG1024	Enoyl-CoA hydratase
FORC4_RS00230	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC4_RS00235	COG1739	Uncharacterized protein family UPF0029
FORC4_RS00240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC4_RS00280	COG0583	DNA-binding transcription factor activity
FORC4_RS00285	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC4_RS00290	COG2960	long-chain fatty acid transporting porin activity
FORC4_RS00295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_RS00300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_RS00355	COG4172	Belongs to the ABC transporter superfamily
FORC4_RS00360	COG0747	negative chemotaxis
FORC4_RS00365	COG0601	transmembrane transport
FORC4_RS00370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC4_RS00405	COG1609	Transcriptional regulator
FORC4_RS00410	COG0583	DNA-binding transcription factor activity
FORC4_RS00425	COG0129	dihydroxy-acid dehydratase activity
FORC4_RS00430	COG3265	gluconokinase activity
FORC4_RS00435	COG2610	gluconate transmembrane transporter activity
FORC4_RS00440	COG0800	Aldolase
FORC4_RS00445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC4_RS00450	COG0583	DNA-binding transcription factor activity
FORC4_RS00455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC4_RS00460	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC4_RS00465	COG0339	signal peptide processing
FORC4_RS00470	COG1522	sequence-specific DNA binding
FORC4_RS00475	COG5002	protein histidine kinase activity
FORC4_RS00475	COG5001	Diguanylate cyclase
FORC4_RS00480	COG0742	ribosomal rna small subunit methyltransferase
FORC4_RS00495	COG0589	response to stress
FORC4_RS00500	COG1528	Iron-storage protein
FORC4_RS00510	COG2081	HI0933 family
FORC4_RS00520	COG2823	Periplasmic or secreted lipoprotein
FORC4_RS00535	COG1597	lipid kinase activity
FORC4_RS00565	COG0628	permease
FORC4_RS00580	COG1322	Protein conserved in bacteria
FORC4_RS00585	COG2226	methyltransferase
FORC4_RS00590	COG3165	ubiquinone biosynthetic process from chorismate
FORC4_RS00595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC4_RS00600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC4_RS00605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC4_RS00610	COG0805	protein transport
FORC4_RS00615	COG0084	hydrolase, TatD family'
FORC4_RS00630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC4_RS00630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC4_RS00635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC4_RS00670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC4_RS00680	COG2204	response regulator
FORC4_RS00685	COG3852	Histidine kinase
FORC4_RS00695	COG0174	glutamine synthetase
FORC4_RS00700	COG1217	gtp-binding protein TYPA
FORC4_RS00715	COG1295	ribonuclease BN
FORC4_RS00720	COG1490	D-aminoacyl-tRNA deacylase activity
FORC4_RS00725	COG0456	acetyltransferase
FORC4_RS00735	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC4_RS00740	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC4_RS00745	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC4_RS00750	COG3031	protein transport across the cell outer membrane
FORC4_RS00760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC4_RS00765	COG1459	type II secretion system
FORC4_RS00770	COG2165	general secretion pathway protein
FORC4_RS00775	COG2165	general secretion pathway protein
FORC4_RS00780	COG2165	general secretion pathway protein
FORC4_RS00785	COG4795	General secretion pathway protein
FORC4_RS00790	COG3156	type II secretion system protein K
FORC4_RS00795	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC4_RS00800	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC4_RS00810	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC4_RS00815	COG0494	nUDIX hydrolase
FORC4_RS00820	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC4_RS00820	COG0316	Belongs to the HesB IscA family
FORC4_RS00825	COG1040	competence protein
FORC4_RS00830	COG0596	Alpha beta hydrolase
FORC4_RS00840	COG2183	response to ionizing radiation
FORC4_RS00850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC4_RS00870	COG2233	PERMEase
FORC4_RS00880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC4_RS00885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC4_RS00890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC4_RS00895	COG1758	RNA polymerase activity
FORC4_RS00900	COG0194	GDP metabolic process
FORC4_RS00915	COG0848	biopolymer transport protein
FORC4_RS00920	COG0811	peptide transport
FORC4_RS00940	COG4174	ABC transporter (Permease)
FORC4_RS00945	COG4239	(ABC) transporter, permease
FORC4_RS00950	COG0747	negative chemotaxis
FORC4_RS00955	COG0444	Belongs to the ABC transporter superfamily
FORC4_RS00960	COG4608	Belongs to the ABC transporter superfamily
FORC4_RS00970	COG1561	YicC-like family, N-terminal region
FORC4_RS00975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC4_RS00980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC4_RS00985	COG1560	Kdo2-lipid A biosynthetic process
FORC4_RS00990	COG1309	transcriptional regulator
FORC4_RS00995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC4_RS01005	COG2003	Belongs to the UPF0758 family
FORC4_RS01010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC4_RS01020	COG2194	sulfuric ester hydrolase activity
FORC4_RS01030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC4_RS01035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC4_RS01050	COG0463	Glycosyl transferase, family 2
FORC4_RS01055	COG0859	PFAM glycosyl transferase family 9
FORC4_RS01060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC4_RS01065	COG3642	lipopolysaccharide core region biosynthetic process
FORC4_RS01070	COG1083	cytidylyl-transferase
FORC4_RS01080	COG0728	peptidoglycan biosynthetic process
FORC4_RS01095	COG0367	asparagine synthase
FORC4_RS01110	COG1519	Transferase
FORC4_RS01115	COG0859	PFAM glycosyl transferase family 9
FORC4_RS01125	COG1560	Kdo2-lipid A biosynthetic process
FORC4_RS01135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC4_RS01165	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
FORC4_RS01200	COG1216	Glycosyl transferase, family 2
FORC4_RS01210	COG1216	Glycosyl transferase, family 2
FORC4_RS01230	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FORC4_RS01235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC4_RS01255	COG1482	cell wall glycoprotein biosynthetic process
FORC4_RS01260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC4_RS01275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FORC4_RS01280	COG0149	triose-phosphate isomerase activity
FORC4_RS01305	COG1494	fructose-1,6-bisphosphatase
FORC4_RS01310	COG3074	FtsZ-dependent cytokinesis
FORC4_RS01315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC4_RS01320	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC4_RS01325	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC4_RS01330	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC4_RS01340	COG1609	Transcriptional regulator
FORC4_RS01345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC4_RS01350	COG0254	rRNA binding
FORC4_RS01360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC4_RS01365	COG0088	Forms part of the polypeptide exit tunnel
FORC4_RS01375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC4_RS01380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC4_RS01385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC4_RS01390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC4_RS01400	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC4_RS01405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC4_RS01410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC4_RS01415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC4_RS01420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC4_RS01425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC4_RS01430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC4_RS01435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC4_RS01450	COG1841	ribosomal large subunit assembly
FORC4_RS01455	COG0200	Binds to the 23S rRNA
FORC4_RS01460	COG0201	protein transport
FORC4_RS01465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FORC4_RS01470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC4_RS01475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC4_RS01485	COG0202	RNA polymerase activity
FORC4_RS01490	COG0203	ribosomal protein L17
FORC4_RS01500	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC4_RS01510	COG2153	protein acetylation
FORC4_RS01515	COG0513	Belongs to the DEAD box helicase family
FORC4_RS01525	COG0737	Belongs to the 5'-nucleotidase family
FORC4_RS01530	COG1648	precorrin-2 dehydrogenase activity
FORC4_RS01530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC4_RS01535	COG0175	sulfate reduction
FORC4_RS01540	COG2895	sulfate adenylyltransferase (ATP) activity
FORC4_RS01545	COG0471	metal ion transport
FORC4_RS01545	COG3273	potassium ion transport
FORC4_RS01550	COG0529	Catalyzes the synthesis of activated sulfate
FORC4_RS01570	COG4181	ATPase activity
FORC4_RS01585	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC4_RS01595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC4_RS01600	COG0729	surface antigen
FORC4_RS01610	COG2105	PFAM AIG2 family protein
FORC4_RS01620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC4_RS01625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC4_RS01630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC4_RS01635	COG0163	prenyltransferase activity
FORC4_RS01640	COG4143	(ABC) transporter
FORC4_RS01645	COG1178	ABC-type Fe3 transport system permease component
FORC4_RS01650	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC4_RS01665	COG2358	TRAP transporter, solute receptor (TAXI family
FORC4_RS01675	COG0039	L-malate dehydrogenase activity
FORC4_RS01685	COG0142	geranyltranstransferase activity
FORC4_RS01690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC4_RS01700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC4_RS01705	COG2966	Psort location CytoplasmicMembrane, score
FORC4_RS01720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC4_RS01725	COG2967	ApaG domain
FORC4_RS01730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC4_RS01735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC4_RS01740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC4_RS01745	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC4_RS01750	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC4_RS01760	COG0066	3-isopropylmalate dehydratase activity
FORC4_RS01765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC4_RS01770	COG0473	3-isopropylmalate dehydrogenase activity
FORC4_RS01775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC4_RS01795	COG0583	DNA-binding transcription factor activity
FORC4_RS01800	COG1022	Amp-dependent synthetase and ligase
FORC4_RS01805	COG0028	Belongs to the TPP enzyme family
FORC4_RS01810	COG0440	acetolactate synthase activity
FORC4_RS01825	COG0469	pyruvate kinase activity
FORC4_RS01830	COG1349	DNA-binding transcription factor activity
FORC4_RS01835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC4_RS01850	COG5002	protein histidine kinase activity
FORC4_RS01860	COG2376	Dihydroxyacetone kinase
FORC4_RS01865	COG1461	Dihydroxyacetone kinase
FORC4_RS01880	COG3722	fumarate hydratase activity
FORC4_RS01885	COG0246	Mannitol dehydrogenase
FORC4_RS01890	COG2213	PTS system mannitol-specific
FORC4_RS01890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_RS01920	COG2207	Transcriptional regulator
FORC4_RS01930	COG1464	Belongs to the NlpA lipoprotein family
FORC4_RS01945	COG0358	DNA primase activity
FORC4_RS01950	COG1610	YqeY-like protein
FORC4_RS01955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC4_RS01960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC4_RS01965	COG0596	Alpha beta hydrolase
FORC4_RS01970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC4_RS01975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC4_RS01980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC4_RS01985	COG1968	undecaprenyl-diphosphatase activity
FORC4_RS01990	COG0617	tRNA 3'-terminal CCA addition
FORC4_RS01995	COG3267	Type II secretory pathway component ExeA
FORC4_RS01995	COG3409	Peptidoglycan-binding domain 1 protein
FORC4_RS02005	COG4991	sh3 domain protein
FORC4_RS02010	COG0306	phosphate transporter
FORC4_RS02015	COG1392	Phosphate transport regulator
FORC4_RS02020	COG3025	triphosphatase activity
FORC4_RS02035	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC4_RS02040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC4_RS02040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC4_RS02045	COG1538	Outer membrane efflux protein
FORC4_RS02050	COG0494	nUDIX hydrolase
FORC4_RS02055	COG3151	Protein conserved in bacteria
FORC4_RS02065	COG3150	esterase
FORC4_RS02075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC4_RS02080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC4_RS02090	COG3105	Protein conserved in bacteria
FORC4_RS02095	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC4_RS02100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC4_RS02105	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC4_RS02110	COG0723	plastoquinol--plastocyanin reductase activity
FORC4_RS02115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC4_RS02120	COG2857	Cytochrome c1
FORC4_RS02125	COG0625	glutathione transferase activity
FORC4_RS02130	COG2969	positive regulation of protein catabolic process
FORC4_RS02135	COG2823	Periplasmic or secreted lipoprotein
FORC4_RS02140	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC4_RS02145	COG0792	nuclease activity
FORC4_RS02155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC4_RS02160	COG0275	rRNA processing
FORC4_RS02165	COG3116	cell division
FORC4_RS02170	COG0768	penicillin binding
FORC4_RS02175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC4_RS02180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC4_RS02185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC4_RS02190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC4_RS02195	COG0772	Belongs to the SEDS family
FORC4_RS02200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC4_RS02205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC4_RS02210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC4_RS02215	COG0849	cell division
FORC4_RS02220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC4_RS02225	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORC4_RS02235	COG0653	protein targeting
FORC4_RS02240	COG0494	nUDIX hydrolase
FORC4_RS02245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC4_RS02250	COG0505	Belongs to the CarA family
FORC4_RS02255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC4_RS02270	COG0730	response to heat
FORC4_RS02275	COG0583	DNA-binding transcription factor activity
FORC4_RS02280	COG2860	membrane
FORC4_RS02285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC4_RS02295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC4_RS02305	COG0493	'glutamate synthase
FORC4_RS02310	COG0069	glutamate synthase activity
FORC4_RS02310	COG0070	glutamate synthase
FORC4_RS02310	COG0067	glutamate synthase
FORC4_RS02320	COG0067	glutamate synthase
FORC4_RS02320	COG0069	glutamate synthase activity
FORC4_RS02320	COG0070	glutamate synthase
FORC4_RS02325	COG1242	4 iron, 4 sulfur cluster binding
FORC4_RS02330	COG2203	Gaf domain
FORC4_RS02330	COG3706	GGDEF domain
FORC4_RS02330	COG4251	negative regulation of phosphorylation
FORC4_RS02330	COG5001	Diguanylate cyclase
FORC4_RS02335	COG0784	Response regulator, receiver
FORC4_RS02335	COG5002	protein histidine kinase activity
FORC4_RS02335	COG2198	Histidine kinase
FORC4_RS02345	COG0745	RESPONSE REGULATOR receiver
FORC4_RS02355	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC4_RS02370	COG0083	homoserine kinase activity
FORC4_RS02375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC4_RS02380	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC4_RS02385	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC4_RS02390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC4_RS02405	COG1115	amino acid carrier protein
FORC4_RS02410	COG3022	response to hydroperoxide
FORC4_RS02415	COG0513	Belongs to the DEAD box helicase family
FORC4_RS02420	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC4_RS02430	COG0716	FMN binding
FORC4_RS02435	COG4974	Belongs to the 'phage' integrase family
FORC4_RS02440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC4_RS02445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC4_RS02450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC4_RS02455	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC4_RS02470	COG0667	Aldo Keto reductase
FORC4_RS02480	COG3066	DNA modification
FORC4_RS02485	COG0494	nUDIX hydrolase
FORC4_RS02495	COG0730	response to heat
FORC4_RS02500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC4_RS02505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC4_RS02515	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC4_RS02520	COG0583	DNA-binding transcription factor activity
FORC4_RS02525	COG0640	Transcriptional regulator
FORC4_RS02530	COG0268	Binds directly to 16S ribosomal RNA
FORC4_RS02535	COG0728	peptidoglycan biosynthetic process
FORC4_RS02540	COG0196	riboflavin kinase activity
FORC4_RS02545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC4_RS02550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC4_RS02555	COG1047	Peptidyl-prolyl cis-trans
FORC4_RS02560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC4_RS02565	COG3279	Response regulator of the LytR AlgR family
FORC4_RS02570	COG3275	phosphorelay sensor kinase activity
FORC4_RS02575	COG1966	Carbon starvation protein
FORC4_RS02590	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC4_RS02595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC4_RS02600	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC4_RS02605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC4_RS02610	COG1605	Chorismate mutase
FORC4_RS02610	COG0287	Prephenate dehydrogenase
FORC4_RS02615	COG0739	heme binding
FORC4_RS02630	COG0488	(ABC) transporter
FORC4_RS02640	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC4_RS02645	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC4_RS02650	COG1605	Chorismate mutase
FORC4_RS02650	COG0077	Prephenate dehydratase
FORC4_RS02655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC4_RS02660	COG0741	lytic transglycosylase activity
FORC4_RS02665	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC4_RS02670	COG0564	pseudouridine synthase activity
FORC4_RS02680	COG0542	response to heat
FORC4_RS02735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC4_RS02740	COG0826	peptidase U32
FORC4_RS02745	COG2974	May be involved in recombination
FORC4_RS02750	COG0745	RESPONSE REGULATOR receiver
FORC4_RS02755	COG5002	protein histidine kinase activity
FORC4_RS02765	COG0248	Ppx GppA phosphatase
FORC4_RS02770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC4_RS02780	COG0581	inorganic phosphate transmembrane transporter activity
FORC4_RS02785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC4_RS02790	COG0704	Plays a role in the regulation of phosphate uptake
FORC4_RS02800	COG3142	Participates in the control of copper homeostasis
FORC4_RS02805	COG0450	alkyl hydroperoxide reductase
FORC4_RS02810	COG0583	DNA-binding transcription factor activity
FORC4_RS02815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC4_RS02825	COG0517	IMP dehydrogenase activity
FORC4_RS02835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC4_RS02840	COG0343	queuine tRNA-ribosyltransferase activity
FORC4_RS02845	COG1862	Preprotein translocase
FORC4_RS02850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC4_RS02855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC4_RS02860	COG0483	inositol monophosphate 1-phosphatase activity
FORC4_RS02870	COG1959	2 iron, 2 sulfur cluster binding
FORC4_RS02875	COG1104	cysteine desulfurase activity
FORC4_RS02880	COG0822	iron-sulfur transferase activity
FORC4_RS02890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC4_RS02895	COG0443	Heat shock 70 kDa protein
FORC4_RS02900	COG0633	Ferredoxin
FORC4_RS02905	COG2975	iron-sulfur cluster assembly
FORC4_RS02910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC4_RS02915	COG0105	UTP biosynthetic process
FORC4_RS02920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC4_RS02930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC4_RS02935	COG0124	histidyl-tRNA synthetase
FORC4_RS02940	COG2976	Protein conserved in bacteria
FORC4_RS02945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC4_RS02950	COG1160	GTP binding
FORC4_RS02965	COG1570	exodeoxyribonuclease VII activity
FORC4_RS02970	COG0516	GMP reductase activity
FORC4_RS02970	COG0517	IMP dehydrogenase activity
FORC4_RS02975	COG0519	Catalyzes the synthesis of GMP from XMP
FORC4_RS02975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC4_RS02980	COG0582	viral genome integration into host DNA
FORC4_RS02990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC4_RS03055	COG1757	Na H antiporter
FORC4_RS03065	COG1584	GPR1 FUN34 yaaH family protein
FORC4_RS03075	COG1115	amino acid carrier protein
FORC4_RS03105	COG2873	o-acetylhomoserine
FORC4_RS03110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC4_RS03130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC4_RS03130	COG3153	acetyltransferase
FORC4_RS03135	COG0583	DNA-binding transcription factor activity
FORC4_RS03145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC4_RS03150	COG2867	negative regulation of translational initiation
FORC4_RS03155	COG2914	Belongs to the UPF0125 (RnfH) family
FORC4_RS03160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC4_RS03165	COG0497	DNA recombination
FORC4_RS03175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC4_RS03180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC4_RS03190	COG0443	Heat shock 70 kDa protein
FORC4_RS03195	COG0484	heat shock protein binding
FORC4_RS03225	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC4_RS03235	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC4_RS03240	COG0047	phosphoribosylformylglycinamidine synthase activity
FORC4_RS03240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC4_RS03265	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC4_RS03270	COG2252	PERMEase
FORC4_RS03275	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC4_RS03280	COG1073	alpha beta
FORC4_RS03290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC4_RS03295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC4_RS03300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC4_RS03305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC4_RS03305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC4_RS03325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC4_RS03330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC4_RS03335	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC4_RS03340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC4_RS03345	COG0142	geranyltranstransferase activity
FORC4_RS03350	COG1722	exodeoxyribonuclease VII activity
FORC4_RS03355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC4_RS03360	COG2885	chlorophyll binding
FORC4_RS03365	COG0301	tRNA thio-modification
FORC4_RS03365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC4_RS03370	COG0583	DNA-binding transcription factor activity
FORC4_RS03380	COG2363	Small membrane protein
FORC4_RS03385	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC4_RS03395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC4_RS03400	COG1611	Belongs to the LOG family
FORC4_RS03415	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC4_RS03415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC4_RS03425	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC4_RS03430	COG1464	Belongs to the NlpA lipoprotein family
FORC4_RS03435	COG2011	ABC-type metal ion transport system permease component
FORC4_RS03440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC4_RS03445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC4_RS03455	COG1263	PTS System
FORC4_RS03455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC4_RS03460	COG0366	Alpha amylase catalytic
FORC4_RS03475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC4_RS03480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC4_RS03485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC4_RS03490	COG0321	lipoyl(octanoyl) transferase activity
FORC4_RS03495	COG2921	Belongs to the UPF0250 family
FORC4_RS03500	COG1686	Belongs to the peptidase S11 family
FORC4_RS03505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC4_RS03510	COG0772	Belongs to the SEDS family
FORC4_RS03515	COG0768	penicillin binding
FORC4_RS03520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC4_RS03525	COG0799	negative regulation of ribosome biogenesis
FORC4_RS03530	COG1466	dna polymerase III delta subunit
FORC4_RS03535	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC4_RS03540	COG0495	leucyl-tRNA aminoacylation
FORC4_RS03545	COG2888	peptidyl-tyrosine sulfation
FORC4_RS03550	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC4_RS03555	COG4535	Mg2 and Co2 transporter CorC
FORC4_RS03560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC4_RS03565	COG1702	phosphate starvation-inducible protein PhoH
FORC4_RS03570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC4_RS03575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC4_RS03690	COG0012	GTP binding
FORC4_RS03695	COG0193	aminoacyl-tRNA hydrolase activity
FORC4_RS03700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC4_RS03705	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC4_RS03710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC4_RS03715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC4_RS03720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC4_RS03725	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC4_RS03730	COG3094	Invasion gene expression up-regulator, SirB
FORC4_RS03735	COG2912	Transglutaminase-like superfamily
FORC4_RS03740	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC4_RS03745	COG0737	Belongs to the 5'-nucleotidase family
FORC4_RS03755	COG1187	pseudouridine synthase activity
FORC4_RS03760	COG2840	Smr protein MutS2
FORC4_RS03790	COG2608	mercury ion transmembrane transporter activity
FORC4_RS03790	COG2217	Heavy metal translocating P-type atpase
FORC4_RS03800	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC4_RS03805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC4_RS03855	COG0835	chemotaxis
FORC4_RS03855	COG0784	Response regulator, receiver
FORC4_RS03860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC4_RS03865	COG1815	bacterial-type flagellum-dependent cell motility
FORC4_RS03870	COG1558	bacterial-type flagellum-dependent cell motility
FORC4_RS03880	COG1749	Flagellar hook protein flgE
FORC4_RS03885	COG4787	bacterial-type flagellum-dependent cell motility
FORC4_RS03895	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC4_RS03900	COG1706	bacterial-type flagellum-dependent cell motility
FORC4_RS03905	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC4_RS03905	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC4_RS03915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_RS03920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_RS03925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_RS03930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_RS03935	COG2190	(PTS) system
FORC4_RS03940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC4_RS03945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_RS03950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC4_RS03955	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC4_RS03960	COG3115	cell septum assembly
FORC4_RS03965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC4_RS03985	COG0330	HflC and HflK could
FORC4_RS03990	COG3118	belongs to the thioredoxin family
FORC4_RS03995	COG0300	oxidoreductase activity
FORC4_RS04000	COG1090	epimerase
FORC4_RS04025	COG0622	Phosphoesterase
FORC4_RS04045	COG3710	Transcriptional regulator
FORC4_RS04050	COG0326	Molecular chaperone. Has ATPase activity
FORC4_RS04055	COG0563	adenylate kinase activity
FORC4_RS04060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC4_RS04065	COG3104	oligopeptide transport
FORC4_RS04070	COG0250	Participates in transcription elongation, termination and antitermination
FORC4_RS04075	COG0367	asparagine synthase
FORC4_RS04080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC4_RS04080	COG4651	solute:proton antiporter activity
FORC4_RS04085	COG1940	carbohydrate kinase activity
FORC4_RS04085	COG1846	Transcriptional regulator
FORC4_RS04090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC4_RS04095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC4_RS04095	COG1263	PTS System
FORC4_RS04100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC4_RS04105	COG0735	belongs to the Fur family
FORC4_RS04115	COG0716	FMN binding
FORC4_RS04125	COG0596	Alpha beta hydrolase
FORC4_RS04130	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC4_RS04135	COG0033	Phosphoglucomutase
FORC4_RS04145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC4_RS04160	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC4_RS04165	COG1053	succinate dehydrogenase
FORC4_RS04170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC4_RS04175	COG0567	Dehydrogenase, E1 component
FORC4_RS04180	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC4_RS04185	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC4_RS04195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC4_RS04200	COG1121	(ABC) transporter
FORC4_RS04205	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC4_RS04210	COG4977	sequence-specific DNA binding
FORC4_RS04215	COG1918	ferrous iron import across plasma membrane
FORC4_RS04235	COG0018	arginyl-trna synthetase
FORC4_RS04240	COG3102	Protein conserved in bacteria
FORC4_RS04245	COG0788	formyltetrahydrofolate deformylase activity
FORC4_RS04250	COG1199	ATP-dependent helicase activity
FORC4_RS04255	COG1214	PFAM Peptidase M22, glycoprotease
FORC4_RS04270	COG2267	carboxylic ester hydrolase activity
FORC4_RS04275	COG0318	PFAM AMP-dependent synthetase and ligase
FORC4_RS04280	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC4_RS04285	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC4_RS04290	COG2894	cell division
FORC4_RS04295	COG0850	regulation of cytokinetic process
FORC4_RS04300	COG3100	YcgL domain-containing protein
FORC4_RS04305	COG2951	lytic endotransglycosylase activity
FORC4_RS04310	COG0583	DNA-binding transcription factor activity
FORC4_RS04315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC4_RS04320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC4_RS04340	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS04350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC4_RS04375	COG2986	histidine ammonia-lyase
FORC4_RS04380	COG1216	Glycosyl transferase, family 2
FORC4_RS04400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC4_RS04405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC4_RS04440	COG1253	flavin adenine dinucleotide binding
FORC4_RS04445	COG0513	Belongs to the DEAD box helicase family
FORC4_RS04450	COG0569	domain protein
FORC4_RS04455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC4_RS04470	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FORC4_RS04475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC4_RS04480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC4_RS04485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC4_RS04495	COG2204	response regulator
FORC4_RS04510	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC4_RS04520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC4_RS04525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC4_RS04530	COG0776	regulation of translation
FORC4_RS04535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC4_RS04540	COG1555	photosystem II stabilization
FORC4_RS04555	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC4_RS04560	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC4_RS04565	COG0436	Aminotransferase
FORC4_RS04570	COG1169	isochorismate synthase
FORC4_RS04575	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC4_RS04580	COG0596	Alpha beta hydrolase
FORC4_RS04585	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC4_RS04605	COG2855	membrane
FORC4_RS04610	COG0477	Major facilitator Superfamily
FORC4_RS04660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_RS04685	COG1522	sequence-specific DNA binding
FORC4_RS04695	COG1946	Acyl-CoA thioesterase
FORC4_RS04700	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC4_RS04715	COG2199	diguanylate cyclase activity
FORC4_RS04720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC4_RS04725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC4_RS04730	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC4_RS04735	COG0516	GMP reductase activity
FORC4_RS04735	COG0517	IMP dehydrogenase activity
FORC4_RS04760	COG0537	adenosine 5'-monophosphoramidase activity
FORC4_RS04785	COG3150	esterase
FORC4_RS04790	COG1252	NADH dehydrogenase
FORC4_RS04805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC4_RS04815	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC4_RS04820	COG1136	(ABC) transporter
FORC4_RS04825	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC4_RS04835	COG0658	competence protein
FORC4_RS04835	COG2333	competence protein COMEC
FORC4_RS04840	COG1132	(ABC) transporter
FORC4_RS04845	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC4_RS04855	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC4_RS04860	COG2719	SpoVR family
FORC4_RS04865	COG2718	Belongs to the UPF0229 family
FORC4_RS04870	COG2766	serine protein kinase
FORC4_RS04875	COG3013	Belongs to the UPF0304 family
FORC4_RS04885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC4_RS04895	COG1882	Formate acetyltransferase
FORC4_RS04935	COG0708	Exodeoxyribonuclease III
FORC4_RS04945	COG3923	Primosomal replication protein n
FORC4_RS04950	COG0730	response to heat
FORC4_RS04955	COG1199	ATP-dependent helicase activity
FORC4_RS04965	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC4_RS04970	COG1187	pseudouridine synthase activity
FORC4_RS04980	COG1278	Cold shock
FORC4_RS04985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC4_RS04990	COG0542	response to heat
FORC4_RS05000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC4_RS05005	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC4_RS05010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC4_RS05020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC4_RS05030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC4_RS05035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC4_RS05040	COG0297	glycogen (starch) synthase activity
FORC4_RS05060	COG3070	regulator of competence-specific genes
FORC4_RS05065	COG1609	Transcriptional regulator
FORC4_RS05070	COG3381	protein complex oligomerization
FORC4_RS05075	COG0745	RESPONSE REGULATOR receiver
FORC4_RS05080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC4_RS05085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC4_RS05090	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC4_RS05095	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC4_RS05100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC4_RS05115	COG0189	ligase activity
FORC4_RS05115	COG4067	protein conserved in archaea
FORC4_RS05120	COG0500	methyltransferase
FORC4_RS05125	COG4106	trans-aconitate 2-methyltransferase activity
FORC4_RS05135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC4_RS05140	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC4_RS05145	COG0840	transmembrane signaling receptor activity
FORC4_RS05150	COG0632	four-way junction helicase activity
FORC4_RS05155	COG2255	four-way junction helicase activity
FORC4_RS05160	COG1271	oxidase subunit
FORC4_RS05165	COG1294	oxidase, subunit
FORC4_RS05170	COG4890	Cyd operon protein YbgT
FORC4_RS05180	COG0824	Thioesterase
FORC4_RS05185	COG0811	peptide transport
FORC4_RS05200	COG0823	Involved in the tonB-independent uptake of proteins
FORC4_RS05205	COG2885	chlorophyll binding
FORC4_RS05210	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC4_RS05215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC4_RS05225	COG3766	membrane
FORC4_RS05235	COG0754	glutathionylspermidine amidase activity
FORC4_RS05245	COG5002	protein histidine kinase activity
FORC4_RS05245	COG0784	Response regulator, receiver
FORC4_RS05275	COG0840	transmembrane signaling receptor activity
FORC4_RS05280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_RS05285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_RS05310	COG3568	Endonuclease Exonuclease Phosphatase
FORC4_RS05325	COG0583	DNA-binding transcription factor activity
FORC4_RS05335	COG0686	Belongs to the AlaDH PNT family
FORC4_RS05345	COG1674	ftsk spoiiie
FORC4_RS05350	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC4_RS05355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC4_RS05360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC4_RS05375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC4_RS05380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC4_RS05385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC4_RS05390	COG0156	8-amino-7-oxononanoate synthase activity
FORC4_RS05400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC4_RS05405	COG0501	Belongs to the peptidase M48B family
FORC4_RS05415	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS05430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC4_RS05450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC4_RS05455	COG2915	High frequency lysogenization protein hflD homolog
FORC4_RS05460	COG0482	sulfurtransferase activity
FORC4_RS05470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC4_RS05480	COG1757	Na H antiporter
FORC4_RS05495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC4_RS05500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORC4_RS05505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC4_RS05510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC4_RS05510	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC4_RS05515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC4_RS05520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC4_RS05525	COG0107	imidazoleglycerol-phosphate synthase activity
FORC4_RS05530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC4_RS05530	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC4_RS05535	COG3012	SEC-C Motif Domain Protein
FORC4_RS05540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC4_RS05545	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC4_RS05550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC4_RS05555	COG0215	cysteine-tRNA ligase activity
FORC4_RS05560	COG1435	thymidine kinase activity
FORC4_RS05565	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC4_RS05590	COG2116	formate transmembrane transporter activity
FORC4_RS05595	COG0390	transport system, permease component
FORC4_RS05600	COG4459	periplasmic nitrate reductase
FORC4_RS05605	COG3005	denitrification pathway
FORC4_RS05610	COG0243	molybdopterin cofactor binding
FORC4_RS05625	COG1227	inorganic diphosphatase activity
FORC4_RS05635	COG4172	Belongs to the ABC transporter superfamily
FORC4_RS05645	COG4171	peptide transport system, permease
FORC4_RS05660	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC4_RS05665	COG1842	Phage shock protein A
FORC4_RS05675	COG1983	PspC domain protein
FORC4_RS05680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_RS05695	COG2818	Glycosylase
FORC4_RS05700	COG5380	lipid catabolic process
FORC4_RS05705	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC4_RS05710	COG0626	cystathionine gamma-synthase activity
FORC4_RS05720	COG0733	neurotransmitter:sodium symporter activity
FORC4_RS05730	COG0564	pseudouridine synthase activity
FORC4_RS05740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC4_RS05745	COG1151	hydroxylamine reductase activity
FORC4_RS05750	COG3604	Transcriptional regulator
FORC4_RS05760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC4_RS05765	COG4136	ATPase activity
FORC4_RS05770	COG4135	transport system, permease component
FORC4_RS05775	COG4134	Bacterial extracellular solute-binding protein
FORC4_RS05780	COG0398	Pfam SNARE associated Golgi protein
FORC4_RS05790	COG0493	'glutamate synthase
FORC4_RS05815	COG3313	Fe-S protein
FORC4_RS05840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC4_RS05860	COG1061	Type III restriction enzyme res subunit
FORC4_RS05865	COG1187	pseudouridine synthase activity
FORC4_RS05870	COG2814	Major facilitator Superfamily
FORC4_RS05900	COG3005	denitrification pathway
FORC4_RS05905	COG0702	epimerase
FORC4_RS05910	COG0534	Mate efflux family protein
FORC4_RS05915	COG4181	ATPase activity
FORC4_RS05930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC4_RS05945	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC4_RS05950	COG3273	potassium ion transport
FORC4_RS05950	COG2985	domain, Protein
FORC4_RS05955	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC4_RS05965	COG1737	Transcriptional regulator
FORC4_RS05970	COG0076	glutamate decarboxylase activity
FORC4_RS05980	COG2431	L-lysine efflux transmembrane transporter activity
FORC4_RS05990	COG3070	regulator of competence-specific genes
FORC4_RS06005	COG4191	Histidine kinase
FORC4_RS06005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_RS06015	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC4_RS06020	COG3048	D-serine ammonia-lyase activity
FORC4_RS06025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC4_RS06030	COG4988	ABC transporter
FORC4_RS06035	COG0492	ferredoxin-NADP+ reductase activity
FORC4_RS06060	COG0471	metal ion transport
FORC4_RS06065	COG2949	membrane
FORC4_RS06070	COG0281	malic enzyme
FORC4_RS06075	COG1643	Atp-dependent helicase
FORC4_RS06080	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC4_RS06095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC4_RS06130	COG0277	FAD linked oxidase domain protein
FORC4_RS06130	COG0247	lactate metabolic process
FORC4_RS06145	COG2986	histidine ammonia-lyase
FORC4_RS06150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC4_RS06155	COG0010	Belongs to the arginase family
FORC4_RS06160	COG1228	amidohydrolase
FORC4_RS06165	COG2188	Transcriptional regulator
FORC4_RS06180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC4_RS06190	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC4_RS06200	COG0393	Putative heavy-metal-binding
FORC4_RS06230	COG3706	GGDEF domain
FORC4_RS06235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC4_RS06240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC4_RS06240	COG0072	phenylalanine-tRNA ligase activity
FORC4_RS06250	COG0776	regulation of translation
FORC4_RS06260	COG0500	methyltransferase
FORC4_RS06265	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC4_RS06270	COG0295	cytidine deaminase activity
FORC4_RS06275	COG1346	cytolysis
FORC4_RS06280	COG1380	Effector of murein hydrolase LrgA
FORC4_RS06285	COG2925	Exonuclease
FORC4_RS06290	COG1823	symporter activity
FORC4_RS06295	COG0702	epimerase
FORC4_RS06300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC4_RS06305	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC4_RS06325	COG2988	succinylglutamate desuccinylase activity
FORC4_RS06330	COG4139	cobalamin transport
FORC4_RS06335	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC4_RS06355	COG0583	DNA-binding transcription factor activity
FORC4_RS06375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC4_RS06380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC4_RS06385	COG3475	LICD family
FORC4_RS06390	COG1451	nucleotide metabolic process
FORC4_RS06395	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC4_RS06425	COG3938	Belongs to the proline racemase family
FORC4_RS06440	COG2423	ornithine cyclodeaminase activity
FORC4_RS06445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC4_RS06450	COG3842	ATPase activity
FORC4_RS06455	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC4_RS06460	COG1177	transmembrane transport
FORC4_RS06470	COG3291	Pkd domain containing protein
FORC4_RS06485	COG0444	Belongs to the ABC transporter superfamily
FORC4_RS06490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC4_RS06495	COG0601	transmembrane transport
FORC4_RS06505	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC4_RS06520	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC4_RS06530	COG0625	glutathione transferase activity
FORC4_RS06570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC4_RS06575	COG1127	ABC transporter
FORC4_RS06590	COG3264	Mechanosensitive ion channel
FORC4_RS06590	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC4_RS06620	COG0531	amino acid
FORC4_RS06630	COG0531	amino acid
FORC4_RS06640	COG1982	Orn Lys Arg decarboxylase major
FORC4_RS06645	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC4_RS06660	COG0583	DNA-binding transcription factor activity
FORC4_RS06665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC4_RS06700	COG0471	metal ion transport
FORC4_RS06705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_RS06705	COG4191	Histidine kinase
FORC4_RS06715	COG5001	Diguanylate cyclase
FORC4_RS06715	COG3300	MHYT domain
FORC4_RS06725	COG1280	lysine exporter protein (LysE YggA)
FORC4_RS06730	COG1328	CTP reductase activity
FORC4_RS06735	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC4_RS06745	COG0861	Integral membrane protein TerC family
FORC4_RS06750	COG0739	heme binding
FORC4_RS06770	COG2885	chlorophyll binding
FORC4_RS06790	COG3501	Rhs element vgr protein
FORC4_RS06815	COG0515	serine threonine protein kinase
FORC4_RS06850	COG1522	sequence-specific DNA binding
FORC4_RS06945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC4_RS06955	COG0814	amino acid
FORC4_RS06975	COG1132	(ABC) transporter
FORC4_RS06980	COG1132	(ABC) transporter
FORC4_RS07005	COG0443	Heat shock 70 kDa protein
FORC4_RS07010	COG0443	Heat shock 70 kDa protein
FORC4_RS07020	COG3706	GGDEF domain
FORC4_RS07050	COG0243	molybdopterin cofactor binding
FORC4_RS07055	COG0437	4 iron, 4 sulfur cluster binding
FORC4_RS07060	COG3302	dmso reductase anchor subunit
FORC4_RS07065	COG3381	protein complex oligomerization
FORC4_RS07075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC4_RS07080	COG1643	Atp-dependent helicase
FORC4_RS07095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC4_RS07105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC4_RS07110	COG1215	transferase activity, transferring glycosyl groups
FORC4_RS07115	COG0438	transferase activity, transferring glycosyl groups
FORC4_RS07145	COG0438	transferase activity, transferring glycosyl groups
FORC4_RS07155	COG2204	response regulator
FORC4_RS07185	COG1793	dna ligase
FORC4_RS07195	COG0534	Mate efflux family protein
FORC4_RS07200	COG0307	riboflavin synthase, alpha
FORC4_RS07210	COG3001	Fructosamine kinase
FORC4_RS07215	COG2201	protein-glutamate methylesterase activity
FORC4_RS07220	COG3706	GGDEF domain
FORC4_RS07230	COG0791	NLP P60 protein
FORC4_RS07235	COG0840	transmembrane signaling receptor activity
FORC4_RS07235	COG3290	protein histidine kinase activity
FORC4_RS07270	COG3148	PFAM DTW domain containing protein
FORC4_RS07275	COG1940	carbohydrate kinase activity
FORC4_RS07290	COG0746	molybdenum cofactor guanylyltransferase activity
FORC4_RS07295	COG3842	ATPase activity
FORC4_RS07310	COG2204	response regulator
FORC4_RS07315	COG4191	Histidine kinase
FORC4_RS07320	COG0488	(ABC) transporter
FORC4_RS07325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC4_RS07345	COG3381	protein complex oligomerization
FORC4_RS07355	COG0243	molybdopterin cofactor binding
FORC4_RS07355	COG3383	formate dehydrogenase (NAD+) activity
FORC4_RS07360	COG0437	4 iron, 4 sulfur cluster binding
FORC4_RS07410	COG0004	ammonium transporteR
FORC4_RS07420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC4_RS07425	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC4_RS07435	COG1177	transmembrane transport
FORC4_RS07445	COG3842	ATPase activity
FORC4_RS07465	COG0037	tRNA processing
FORC4_RS07470	COG0589	response to stress
FORC4_RS07475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC4_RS07490	COG2217	Heavy metal translocating P-type atpase
FORC4_RS07500	COG2010	Cytochrome c
FORC4_RS07515	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC4_RS07530	COG2205	protein histidine kinase activity
FORC4_RS07530	COG0784	Response regulator, receiver
FORC4_RS07580	COG4128	Pfam Zonular occludens toxin
FORC4_RS07625	COG4128	Pfam Zonular occludens toxin
FORC4_RS07765	COG3120	sequence-specific DNA binding
FORC4_RS07770	COG1067	ATP-dependent peptidase activity
FORC4_RS07775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC4_RS07790	COG0488	(ABC) transporter
FORC4_RS07800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC4_RS07800	COG0116	Belongs to the methyltransferase superfamily
FORC4_RS07810	COG0167	dihydroorotate dehydrogenase activity
FORC4_RS07815	COG2902	Dehydrogenase
FORC4_RS07820	COG0308	aminopeptidase N
FORC4_RS07835	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FORC4_RS07840	COG1956	GAF domain-containing protein
FORC4_RS07845	COG1132	(ABC) transporter
FORC4_RS07850	COG2995	paraquat-inducible protein a
FORC4_RS07855	COG3008	intermembrane lipid transfer
FORC4_RS07860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC4_RS07860	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FORC4_RS07880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC4_RS07885	COG1666	GTP binding
FORC4_RS07895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_RS07900	COG4597	amino acid ABC transporter
FORC4_RS07905	COG0765	amino acid transport
FORC4_RS07910	COG1126	abc transporter atp-binding protein
FORC4_RS07915	COG0670	Belongs to the BI1 family
FORC4_RS07925	COG2920	part of a sulfur-relay system
FORC4_RS07930	COG1254	Belongs to the acylphosphatase family
FORC4_RS07935	COG0840	transmembrane signaling receptor activity
FORC4_RS07940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC4_RS07980	COG3706	GGDEF domain
FORC4_RS07985	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC4_RS07990	COG0602	queuosine metabolic process
FORC4_RS07995	COG0561	phosphatase activity
FORC4_RS08020	COG2828	Protein conserved in bacteria
FORC4_RS08030	COG0372	Belongs to the citrate synthase family
FORC4_RS08035	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC4_RS08065	COG0730	response to heat
FORC4_RS08085	COG0457	Tetratricopeptide repeat
FORC4_RS08155	COG4790	Type iii secretion
FORC4_RS08160	COG4794	Type iii secretion
FORC4_RS08165	COG4791	protein targeting
FORC4_RS08170	COG4792	protein secretion
FORC4_RS08210	COG3177	Filamentation induced by cAMP protein fic
FORC4_RS08230	COG4669	(LipO)protein
FORC4_RS08300	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_RS08305	COG3284	Transcriptional regulator
FORC4_RS08315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC4_RS08320	COG0363	glucosamine-6-phosphate deaminase activity
FORC4_RS08325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC4_RS08330	COG4565	transcriptional regulatory protein
FORC4_RS08335	COG3290	protein histidine kinase activity
FORC4_RS08350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_RS08365	COG1858	cytochrome C peroxidase
FORC4_RS08380	COG0527	aspartate kinase activity
FORC4_RS08385	COG0662	Cupin 2, conserved barrel domain protein
FORC4_RS08390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC4_RS08395	COG0456	acetyltransferase
FORC4_RS08400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC4_RS08420	COG4176	ABC-type proline glycine betaine transport system permease component
FORC4_RS08425	COG2113	Glycine betaine
FORC4_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS08455	COG0745	RESPONSE REGULATOR receiver
FORC4_RS08460	COG0642	Histidine kinase
FORC4_RS08465	COG1368	sulfuric ester hydrolase activity
FORC4_RS08485	COG1115	amino acid carrier protein
FORC4_RS08495	COG1280	lysine exporter protein (LysE YggA)
FORC4_RS08500	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC4_RS08505	COG1560	Kdo2-lipid A biosynthetic process
FORC4_RS08510	COG0531	amino acid
FORC4_RS08520	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC4_RS08525	COG3063	Type IV pilus biogenesis stability protein PilW
FORC4_RS08555	COG0110	maltose O-acetyltransferase activity
FORC4_RS08575	COG2315	Protein conserved in bacteria
FORC4_RS08580	COG1846	Transcriptional regulator
FORC4_RS08600	COG2771	luxR family
FORC4_RS08600	COG2200	EAL domain
FORC4_RS08605	COG1227	inorganic diphosphatase activity
FORC4_RS08610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC4_RS08615	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_RS08620	COG2957	Belongs to the agmatine deiminase family
FORC4_RS08630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC4_RS08635	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_RS08640	COG1917	Cupin 2, conserved barrel domain protein
FORC4_RS08640	COG1396	sequence-specific DNA binding
FORC4_RS08645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FORC4_RS08650	COG0174	glutamine synthetase
FORC4_RS08655	COG1757	Na H antiporter
FORC4_RS08690	COG2161	toxin-antitoxin pair type II binding
FORC4_RS08695	COG4115	mRNA cleavage
FORC4_RS08780	COG4735	regulation of single-species biofilm formation
FORC4_RS08820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC4_RS09085	COG0346	lactoylglutathione lyase activity
FORC4_RS09105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC4_RS09175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC4_RS09285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC4_RS09295	COG3768	UPF0283 membrane protein
FORC4_RS09300	COG3106	COG3106 Predicted ATPase
FORC4_RS09315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC4_RS09320	COG2205	protein histidine kinase activity
FORC4_RS09320	COG0784	Response regulator, receiver
FORC4_RS09335	COG0814	amino acid
FORC4_RS09340	COG1760	l-serine dehydratase
FORC4_RS09345	COG2200	EAL domain
FORC4_RS09355	COG0720	synthase
FORC4_RS09360	COG0840	transmembrane signaling receptor activity
FORC4_RS09365	COG0017	Asparaginyl-tRNA synthetase
FORC4_RS09375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_RS09390	COG1448	Aminotransferase
FORC4_RS09410	COG0840	transmembrane signaling receptor activity
FORC4_RS09415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC4_RS09420	COG1846	Transcriptional regulator
FORC4_RS09445	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC4_RS09460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC4_RS09465	COG3108	Peptidase M15
FORC4_RS09470	COG2989	Protein conserved in bacteria
FORC4_RS09495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC4_RS09505	COG3088	subunit of a heme lyase
FORC4_RS09505	COG4235	cytochrome complex assembly
FORC4_RS09515	COG1138	Cytochrome C-type biogenesis protein
FORC4_RS09520	COG3301	Polysulphide reductase, NrfD
FORC4_RS09525	COG0437	4 iron, 4 sulfur cluster binding
FORC4_RS09535	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC4_RS09555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC4_RS09560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC4_RS09565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC4_RS09590	COG0019	diaminopimelate decarboxylase activity
FORC4_RS09630	COG0322	excinuclease ABC activity
FORC4_RS09635	COG2197	response regulator
FORC4_RS09640	COG0417	DNA replication proofreading
FORC4_RS09650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC4_RS09655	COG3099	Belongs to the UPF0263 family
FORC4_RS09660	COG1187	pseudouridine synthase activity
FORC4_RS09670	COG0009	L-threonylcarbamoyladenylate synthase
FORC4_RS09675	COG0613	PHP domain protein
FORC4_RS09685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC4_RS09690	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC4_RS09695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC4_RS09700	COG0134	indole-3-glycerol-phosphate synthase activity
FORC4_RS09700	COG0135	phosphoribosylanthranilate isomerase activity
FORC4_RS09705	COG0133	tryptophan synthase activity
FORC4_RS09710	COG0159	tryptophan synthase activity
FORC4_RS09715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC4_RS09720	COG0318	PFAM AMP-dependent synthetase and ligase
FORC4_RS09725	COG1301	dicarboxylic acid transport
FORC4_RS09745	COG2917	probably involved in intracellular septation
FORC4_RS09755	COG2350	Protein conserved in bacteria
FORC4_RS09765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC4_RS09770	COG0583	DNA-binding transcription factor activity
FORC4_RS09785	COG5001	Diguanylate cyclase
FORC4_RS09785	COG2203	Gaf domain
FORC4_RS09785	COG3706	GGDEF domain
FORC4_RS09785	COG4251	negative regulation of phosphorylation
FORC4_RS09790	COG1032	radical SAM domain protein
FORC4_RS09795	COG0840	transmembrane signaling receptor activity
FORC4_RS09800	COG0745	RESPONSE REGULATOR receiver
FORC4_RS09805	COG3850	Histidine kinase
FORC4_RS09805	COG5002	protein histidine kinase activity
FORC4_RS09855	COG1335	isochorismatase
FORC4_RS09860	COG1136	(ABC) transporter
FORC4_RS09860	COG0577	efflux transmembrane transporter activity
FORC4_RS09865	COG0577	efflux transmembrane transporter activity
FORC4_RS09865	COG1136	(ABC) transporter
FORC4_RS09870	COG0577	efflux transmembrane transporter activity
FORC4_RS09870	COG1136	(ABC) transporter
FORC4_RS09880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_RS09910	COG3118	belongs to the thioredoxin family
FORC4_RS09915	COG4232	protein-disulfide reductase activity
FORC4_RS09955	COG2863	cytochrome
FORC4_RS09960	COG3258	Cytochrome c
FORC4_RS09965	COG2995	paraquat-inducible protein a
FORC4_RS09970	COG3008	intermembrane lipid transfer
FORC4_RS09970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC4_RS09980	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC4_RS10005	COG4166	transmembrane transport
FORC4_RS10010	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC4_RS10015	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC4_RS10020	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC4_RS10030	COG0539	negative regulation of cytoplasmic translation
FORC4_RS10035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC4_RS10040	COG0616	signal peptide processing
FORC4_RS10045	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS10060	COG0587	DNA-directed DNA polymerase activity
FORC4_RS10065	COG0784	Response regulator, receiver
FORC4_RS10065	COG0835	chemotaxis
FORC4_RS10070	COG1940	carbohydrate kinase activity
FORC4_RS10075	COG0469	pyruvate kinase activity
FORC4_RS10080	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC4_RS10090	COG0733	neurotransmitter:sodium symporter activity
FORC4_RS10100	COG1263	PTS System
FORC4_RS10100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC4_RS10105	COG0084	hydrolase, TatD family'
FORC4_RS10115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC4_RS10120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC4_RS10150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC4_RS10155	COG0416	fatty acid biosynthetic process
FORC4_RS10165	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC4_RS10170	COG0424	maF-like protein
FORC4_RS10175	COG0564	pseudouridine synthase activity
FORC4_RS10180	COG1530	ribonuclease E activity
FORC4_RS10185	COG0659	secondary active sulfate transmembrane transporter activity
FORC4_RS10190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC4_RS10195	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC4_RS10205	COG0572	uridine kinase
FORC4_RS10210	COG0489	protein tyrosine kinase activity
FORC4_RS10215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC4_RS10215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC4_RS10225	COG2186	Transcriptional regulator
FORC4_RS10230	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC4_RS10235	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC4_RS10240	COG0653	protein targeting
FORC4_RS10245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC4_RS10255	COG0366	Alpha amylase catalytic
FORC4_RS10260	COG1122	ATPase activity
FORC4_RS10265	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC4_RS10275	COG3092	negative regulation of chromosome organization
FORC4_RS10280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC4_RS10285	COG0857	belongs to the CobB CobQ family
FORC4_RS10285	COG0280	phosphate acetyltransferase
FORC4_RS10290	COG3174	membrane
FORC4_RS10300	COG0435	Glutathione S-transferase
FORC4_RS10310	COG0444	Belongs to the ABC transporter superfamily
FORC4_RS10315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC4_RS10320	COG0601	transmembrane transport
FORC4_RS10330	COG0314	molybdopterin synthase activity
FORC4_RS10335	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC4_RS10340	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC4_RS10345	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC4_RS10350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC4_RS10355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC4_RS10360	COG2198	Histidine kinase
FORC4_RS10365	COG2204	response regulator
FORC4_RS10370	COG0556	nucleotide-excision repair
FORC4_RS10380	COG4657	Part of a membrane complex involved in electron transport
FORC4_RS10385	COG2878	Part of a membrane complex involved in electron transport
FORC4_RS10390	COG4656	Part of a membrane complex involved in electron transport
FORC4_RS10395	COG4658	electron transport chain
FORC4_RS10400	COG4659	FMN binding
FORC4_RS10405	COG4660	Part of a membrane complex involved in electron transport
FORC4_RS10410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC4_RS10415	COG0346	lactoylglutathione lyase activity
FORC4_RS10425	COG2885	chlorophyll binding
FORC4_RS10430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC4_RS10435	COG2056	Na+-H+ antiporter family
FORC4_RS10445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC4_RS10465	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_RS10465	COG1454	alcohol dehydrogenase
FORC4_RS10470	COG2095	MarC family integral membrane protein
FORC4_RS10475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC4_RS10480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC4_RS10485	COG1757	Na H antiporter
FORC4_RS10500	COG3081	Nucleoid-associated protein
FORC4_RS10505	COG3082	Protein of unknown function (DUF1414)
FORC4_RS10510	COG3083	sulfuric ester hydrolase activity
FORC4_RS10520	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC4_RS10535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC4_RS10540	COG0778	Nitroreductase
FORC4_RS10545	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC4_RS10545	COG1902	pentaerythritol trinitrate reductase activity
FORC4_RS10550	COG0616	signal peptide processing
FORC4_RS10555	COG0252	asparaginase activity
FORC4_RS10560	COG3139	Protein of unknown function (DUF1315)
FORC4_RS10570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC4_RS10575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC4_RS10590	COG2226	methyltransferase
FORC4_RS10605	COG1785	Belongs to the alkaline phosphatase family
FORC4_RS10615	COG0346	lactoylglutathione lyase activity
FORC4_RS10620	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC4_RS10625	COG0668	transmembrane transport
FORC4_RS10630	COG2983	Belongs to the UPF0260 family
FORC4_RS10635	COG2261	transglycosylase associated protein
FORC4_RS10650	COG3681	Belongs to the UPF0597 family
FORC4_RS10655	COG0251	oxidation-reduction process
FORC4_RS10660	COG0814	amino acid
FORC4_RS10665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC4_RS10670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC4_RS10675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC4_RS10685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC4_RS10690	COG2832	Protein of unknown function (DUF454)
FORC4_RS10695	COG0745	RESPONSE REGULATOR receiver
FORC4_RS10700	COG0583	DNA-binding transcription factor activity
FORC4_RS10705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC4_RS10710	COG1286	toxin biosynthetic process
FORC4_RS10715	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC4_RS10720	COG0285	dihydrofolate synthase activity
FORC4_RS10725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC4_RS10730	COG0101	tRNA pseudouridine synthase activity
FORC4_RS10740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC4_RS10745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC4_RS10750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC4_RS10755	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC4_RS10755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC4_RS10760	COG0431	NADPH-dependent FMN reductase
FORC4_RS10770	COG3101	peptidyl-lysine hydroxylation
FORC4_RS10775	COG2860	membrane
FORC4_RS10780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC4_RS10785	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC4_RS10790	COG2840	Smr protein MutS2
FORC4_RS10795	COG2062	phosphohistidine phosphatase, SixA
FORC4_RS10810	COG1024	Enoyl-CoA hydratase
FORC4_RS10810	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC4_RS10815	COG0183	Belongs to the thiolase family
FORC4_RS10830	COG2067	long-chain fatty acid transport protein
FORC4_RS10840	COG2853	Lipoprotein
FORC4_RS10855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC4_RS10860	COG1138	Cytochrome C-type biogenesis protein
FORC4_RS10865	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC4_RS10870	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC4_RS10875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC4_RS10880	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC4_RS10885	COG4133	protoheme IX ABC transporter activity
FORC4_RS10895	COG0835	chemotaxis
FORC4_RS10905	COG1192	Involved in chromosome partitioning
FORC4_RS10910	COG2201	protein-glutamate methylesterase activity
FORC4_RS10915	COG0643	Histidine kinase
FORC4_RS10915	COG2198	Histidine kinase
FORC4_RS10915	COG0784	Response regulator, receiver
FORC4_RS10920	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC4_RS10955	COG1684	flagellar biosynthetic protein fliR
FORC4_RS10960	COG1987	bacterial-type flagellum assembly
FORC4_RS11010	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC4_RS11020	COG1677	Flagellar hook-basal body complex protein FliE
FORC4_RS11040	COG1516	flagellar protein fliS
FORC4_RS11050	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC4_RS11055	COG1334	flagellar protein FlaG
FORC4_RS11060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_RS11065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_RS11070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_RS11075	COG2837	iron assimilation
FORC4_RS11100	COG1393	Belongs to the ArsC family
FORC4_RS11105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC4_RS11120	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FORC4_RS11125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC4_RS11130	COG2716	regulation of RNA biosynthetic process
FORC4_RS11135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC4_RS11150	COG4783	chaperone-mediated protein folding
FORC4_RS11155	COG1393	Belongs to the ArsC family
FORC4_RS11175	COG2233	PERMEase
FORC4_RS11180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC4_RS11185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC4_RS11190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC4_RS11195	COG0121	glutamine amidotransferase
FORC4_RS11200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC4_RS11205	COG1960	acyl-CoA dehydrogenase activity
FORC4_RS11235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC4_RS11240	COG0328	RNA-DNA hybrid ribonuclease activity
FORC4_RS11245	COG2226	methyltransferase
FORC4_RS11250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC4_RS11255	COG0741	lytic transglycosylase activity
FORC4_RS11255	COG1388	LysM domain
FORC4_RS11265	COG3021	interspecies interaction between organisms
FORC4_RS11270	COG0347	Belongs to the P(II) protein family
FORC4_RS11280	COG0037	tRNA processing
FORC4_RS11285	COG0825	malonyl-CoA metabolic process
FORC4_RS11290	COG0587	DNA-directed DNA polymerase activity
FORC4_RS11305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC4_RS11310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC4_RS11315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC4_RS11320	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC4_RS11330	COG0750	zinc metalloprotease
FORC4_RS11335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC4_RS11340	COG0575	Belongs to the CDS family
FORC4_RS11345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC4_RS11350	COG0233	cytoplasmic translational termination
FORC4_RS11355	COG0528	UMP kinase activity
FORC4_RS11360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC4_RS11365	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC4_RS11370	COG0024	Methionine aminopeptidase
FORC4_RS11375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC4_RS11385	COG0564	pseudouridine synthase activity
FORC4_RS11390	COG3098	single-species biofilm formation
FORC4_RS11410	COG1671	Belongs to the UPF0178 family
FORC4_RS11415	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC4_RS11420	COG0254	rRNA binding
FORC4_RS11425	COG1720	tRNA m6t6A37 methyltransferase activity
FORC4_RS11430	COG0442	prolyl-tRNA aminoacylation
FORC4_RS11450	COG0733	neurotransmitter:sodium symporter activity
FORC4_RS11465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC4_RS11470	COG0514	ATP-dependent DNA helicase (RecQ)
FORC4_RS11475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC4_RS11490	COG1477	protein flavinylation
FORC4_RS11495	COG2871	sodium ion transport
FORC4_RS11500	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC4_RS11505	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC4_RS11510	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC4_RS11515	COG1805	sodium ion transport
FORC4_RS11520	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC4_RS11525	COG0271	Belongs to the BolA IbaG family
FORC4_RS11530	COG2813	Specifically methylates the guanine in position
FORC4_RS11535	COG3056	Lipoprotein
FORC4_RS11555	COG1595	DNA-templated transcription, initiation
FORC4_RS11575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC4_RS11580	COG0693	protein deglycase activity
FORC4_RS11585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC4_RS11590	COG3706	GGDEF domain
FORC4_RS11595	COG2166	iron-sulfur cluster assembly
FORC4_RS11600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC4_RS11605	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC4_RS11615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC4_RS11615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC4_RS11620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC4_RS11625	COG1074	ATP-dependent DNA helicase activity
FORC4_RS11635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC4_RS11655	COG3141	response to X-ray
FORC4_RS11660	COG2171	N-acyltransferase activity
FORC4_RS11665	COG0584	glycerophosphoryl diester phosphodiesterase
FORC4_RS11670	COG2271	Major facilitator Superfamily
FORC4_RS11675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC4_RS11680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC4_RS11685	COG1349	DNA-binding transcription factor activity
FORC4_RS11690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC4_RS11695	COG0598	Magnesium transport protein CorA
FORC4_RS11710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC4_RS11715	COG1609	Transcriptional regulator
FORC4_RS11720	COG2211	Major facilitator Superfamily
FORC4_RS11735	COG2017	converts alpha-aldose to the beta-anomer
FORC4_RS11740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC4_RS11750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC4_RS11755	COG1609	Transcriptional regulator
FORC4_RS11760	COG3250	beta-galactosidase activity
FORC4_RS11765	COG2731	YhcH YjgK YiaL family protein
FORC4_RS11770	COG0531	amino acid
FORC4_RS11775	COG0583	DNA-binding transcription factor activity
FORC4_RS11835	COG4964	Belongs to the GSP D family
FORC4_RS11860	COG2169	Transcriptional regulator
FORC4_RS11865	COG1022	Amp-dependent synthetase and ligase
FORC4_RS11875	COG0583	DNA-binding transcription factor activity
FORC4_RS11880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC4_RS11885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC4_RS11895	COG0560	Phosphoserine phosphatase
FORC4_RS11905	COG0813	purine-nucleoside phosphorylase activity
FORC4_RS11910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC4_RS11915	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC4_RS11920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC4_RS11925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC4_RS11930	COG0084	hydrolase, TatD family'
FORC4_RS11940	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC4_RS11960	COG3153	acetyltransferase
FORC4_RS11965	COG3154	lipid carrier protein
FORC4_RS11975	COG0826	peptidase U32
FORC4_RS11980	COG0826	peptidase U32
FORC4_RS11985	COG0534	Mate efflux family protein
FORC4_RS12000	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC4_RS12005	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC4_RS12010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC4_RS12015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC4_RS12020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC4_RS12025	COG0195	Participates in both transcription termination and antitermination
FORC4_RS12030	COG0779	Required for maturation of 30S ribosomal subunits
FORC4_RS12045	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC4_RS12055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC4_RS12060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC4_RS12065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC4_RS12070	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC4_RS12075	COG1534	Rna-binding protein
FORC4_RS12080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC4_RS12085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC4_RS12090	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC4_RS12100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC4_RS12105	COG0739	heme binding
FORC4_RS12110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_RS12120	COG0316	Belongs to the HesB IscA family
FORC4_RS12125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC4_RS12130	COG0628	permease
FORC4_RS12135	COG2813	Specifically methylates the guanine in position
FORC4_RS12140	COG0784	Response regulator, receiver
FORC4_RS12140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_RS12140	COG2205	protein histidine kinase activity
FORC4_RS12140	COG2198	Histidine kinase
FORC4_RS12145	COG0747	negative chemotaxis
FORC4_RS12155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC4_RS12160	COG0444	Belongs to the ABC transporter superfamily
FORC4_RS12165	COG4608	Belongs to the ABC transporter superfamily
FORC4_RS12175	COG2971	BadF BadG BcrA BcrD
FORC4_RS12190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC4_RS12195	COG3842	ATPase activity
FORC4_RS12205	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC4_RS12210	COG0004	ammonium transporteR
FORC4_RS12220	COG3112	Uncharacterised protein family (UPF0231)
FORC4_RS12225	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC4_RS12230	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC4_RS12235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC4_RS12240	COG1643	Atp-dependent helicase
FORC4_RS12245	COG1489	DNA binding
FORC4_RS12255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC4_RS12265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC4_RS12270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC4_RS12275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC4_RS12280	COG1560	Kdo2-lipid A biosynthetic process
FORC4_RS12285	COG0842	Transport permease protein
FORC4_RS12290	COG1131	(ABC) transporter
FORC4_RS12295	COG0659	secondary active sulfate transmembrane transporter activity
FORC4_RS12300	COG0288	reversible hydration of carbon dioxide
FORC4_RS12315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC4_RS12320	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC4_RS12325	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC4_RS12330	COG2186	Transcriptional regulator
FORC4_RS12340	COG0157	Belongs to the NadC ModD family
FORC4_RS12350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC4_RS12355	COG1459	type II secretion system
FORC4_RS12365	COG0237	dephospho-CoA kinase activity
FORC4_RS12370	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC4_RS12375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC4_RS12390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC4_RS12395	COG0228	four-way junction DNA binding
FORC4_RS12400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC4_RS12405	COG4137	Cytochrome C assembly protein
FORC4_RS12410	COG4536	flavin adenine dinucleotide binding
FORC4_RS12415	COG1854	S-ribosylhomocysteine lyase activity
FORC4_RS12425	COG2918	glutathione biosynthetic process
FORC4_RS12430	COG0612	Peptidase, M16
FORC4_RS12435	COG1238	metal cluster binding
FORC4_RS12445	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC4_RS12450	COG0511	ligase activity, forming carbon-carbon bonds
FORC4_RS12450	COG5016	pyruvate
FORC4_RS12455	COG3630	sodium ion export across plasma membrane
FORC4_RS12515	COG0527	aspartate kinase activity
FORC4_RS12520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC4_RS12525	COG2137	regulation of response to DNA damage stimulus
FORC4_RS12530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC4_RS12535	COG1546	Belongs to the CinA family
FORC4_RS12540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC4_RS12555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC4_RS12560	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC4_RS12565	COG0585	pseudouridine synthase activity
FORC4_RS12570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC4_RS12575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC4_RS12580	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC4_RS12585	COG0148	phosphopyruvate hydratase activity
FORC4_RS12590	COG0504	CTP synthase activity
FORC4_RS12595	COG3956	TIGRFAM MazG family protein
FORC4_RS12600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC4_RS12605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC4_RS12615	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC4_RS12620	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC4_RS12625	COG1381	Involved in DNA repair and RecF pathway recombination
FORC4_RS12630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC4_RS12635	COG0571	ribonuclease III activity
FORC4_RS12645	COG0481	GTPase activity
FORC4_RS12650	COG3086	response to oxidative stress
FORC4_RS12660	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC4_RS12665	COG1595	DNA-templated transcription, initiation
FORC4_RS12670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC4_RS12675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FORC4_RS12680	COG0354	folic acid binding
FORC4_RS12695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC4_RS12700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC4_RS12705	COG3079	Belongs to the UPF0149 family
FORC4_RS12710	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC4_RS12715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC4_RS12720	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC4_RS12725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC4_RS12735	COG0583	DNA-binding transcription factor activity
FORC4_RS12745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC4_RS12750	COG0668	transmembrane transport
FORC4_RS12755	COG0191	fructose-bisphosphate aldolase activity
FORC4_RS12760	COG0126	phosphoglycerate kinase activity
FORC4_RS12765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC4_RS12770	COG4771	TonB-dependent receptor
FORC4_RS12775	COG0583	DNA-binding transcription factor activity
FORC4_RS12780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC4_RS12790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC4_RS12800	COG3091	SprT-like family
FORC4_RS12805	COG2356	endonuclease I
FORC4_RS12810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC4_RS12815	COG0189	ligase activity
FORC4_RS12820	COG1678	Uncharacterized ACR, COG1678
FORC4_RS12825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC4_RS12840	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC4_RS12845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC4_RS12850	COG0762	integral membrane protein
FORC4_RS12855	COG1872	DUF167
FORC4_RS12865	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC4_RS12870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC4_RS12875	COG2066	Belongs to the glutaminase family
FORC4_RS12885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC4_RS12895	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC4_RS12900	COG0741	lytic transglycosylase activity
FORC4_RS12970	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_RS13015	COG3437	response regulator, receiver
FORC4_RS13025	COG3394	polysaccharide catabolic process
FORC4_RS13030	COG1486	melibiose metabolic process
FORC4_RS13035	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC4_RS13040	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC4_RS13045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC4_RS13050	COG0726	polysaccharide deacetylase
FORC4_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS13160	COG0795	lipopolysaccharide-transporting ATPase activity
FORC4_RS13165	COG0795	lipopolysaccharide-transporting ATPase activity
FORC4_RS13170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC4_RS13175	COG2927	DNA polymerase III (CHI subunit)
FORC4_RS13180	COG0525	valine-tRNA ligase activity
FORC4_RS13205	COG2235	arginine
FORC4_RS13210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FORC4_RS13215	COG0540	Belongs to the ATCase OTCase family
FORC4_RS13220	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC4_RS13225	COG0251	oxidation-reduction process
FORC4_RS13230	COG0204	Acyl-transferase
FORC4_RS13235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC4_RS13240	COG5007	Belongs to the BolA IbaG family
FORC4_RS13250	COG2854	intermembrane phospholipid transfer
FORC4_RS13255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC4_RS13260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC4_RS13265	COG1127	ABC transporter
FORC4_RS13275	COG0517	IMP dehydrogenase activity
FORC4_RS13275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC4_RS13285	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC4_RS13290	COG1137	ATPase activity
FORC4_RS13300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC4_RS13305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_RS13310	COG1660	Displays ATPase and GTPase activities
FORC4_RS13315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_RS13320	COG2239	Acts as a magnesium transporter
FORC4_RS13325	COG0312	modulator of DNA gyrase
FORC4_RS13330	COG3028	Belongs to the UPF0307 family
FORC4_RS13335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC4_RS13340	COG0564	pseudouridine synthase activity
FORC4_RS13350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC4_RS13355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC4_RS13360	COG0312	modulator of DNA gyrase
FORC4_RS13365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC4_RS13370	COG3164	Protein of unknown function
FORC4_RS13380	COG0424	maF-like protein
FORC4_RS13385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC4_RS13390	COG1792	Involved in formation and maintenance of cell shape
FORC4_RS13395	COG1077	Cell shape determining protein MreB Mrl
FORC4_RS13430	COG2165	general secretion pathway protein
FORC4_RS13440	COG1459	type II secretion system
FORC4_RS13445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC4_RS13455	COG3267	Type II secretory pathway component ExeA
FORC4_RS13455	COG3409	Peptidoglycan-binding domain 1 protein
FORC4_RS13480	COG2199	diguanylate cyclase activity
FORC4_RS13480	COG2200	EAL domain
FORC4_RS13485	COG0629	single-stranded DNA binding
FORC4_RS13500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC4_RS13510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC4_RS13520	COG0527	aspartate kinase activity
FORC4_RS13525	COG0646	methionine synthase
FORC4_RS13525	COG1410	methionine synthase
FORC4_RS13605	COG0175	sulfate reduction
FORC4_RS13610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC4_RS13615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC4_RS13635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC4_RS13640	COG0735	belongs to the Fur family
FORC4_RS13650	COG0166	Belongs to the GPI family
FORC4_RS13655	COG0432	Pfam Uncharacterised protein family UPF0047
FORC4_RS13665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC4_RS13680	COG0359	binds to the 23S rRNA
FORC4_RS13690	COG2965	DNA replication, synthesis of RNA primer
FORC4_RS13695	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC4_RS13705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC4_RS13710	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC4_RS13720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC4_RS13725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC4_RS13755	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC4_RS13765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC4_RS13765	COG0678	peroxiredoxin activity
FORC4_RS13775	COG0165	Argininosuccinate lyase
FORC4_RS13775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC4_RS13780	COG0137	argininosuccinate synthase activity
FORC4_RS13785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC4_RS13790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORC4_RS13795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC4_RS13800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC4_RS13810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC4_RS13815	COG0460	homoserine dehydrogenase
FORC4_RS13815	COG0527	aspartate kinase activity
FORC4_RS13820	COG0626	cystathionine gamma-synthase activity
FORC4_RS13830	COG0281	malic enzyme
FORC4_RS13840	COG2906	2 iron, 2 sulfur cluster binding
FORC4_RS13845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC4_RS13850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC4_RS13855	COG0049	tRNA binding
FORC4_RS13865	COG2168	tRNA wobble position uridine thiolation
FORC4_RS13870	COG2923	Belongs to the DsrF TusC family
FORC4_RS13875	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC4_RS13880	COG2964	Protein conserved in bacteria
FORC4_RS13885	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC4_RS13895	COG2900	Belongs to the SlyX family
FORC4_RS13900	COG1446	asparaginase
FORC4_RS13905	COG1047	Peptidyl-prolyl cis-trans
FORC4_RS13920	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC4_RS13925	COG0488	(ABC) transporter
FORC4_RS13935	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC4_RS13940	COG3089	Belongs to the UPF0270 family
FORC4_RS13945	COG3954	Phosphoribulokinase
FORC4_RS13950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC4_RS13960	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_RS13970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC4_RS13975	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC4_RS13990	COG0180	Tryptophanyl-tRNA synthetase
FORC4_RS13995	COG0546	phosphoglycolate phosphatase activity
FORC4_RS14000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC4_RS14005	COG0557	exoribonuclease II activity
FORC4_RS14010	COG1959	2 iron, 2 sulfur cluster binding
FORC4_RS14015	COG1017	nitric oxide dioxygenase activity
FORC4_RS14015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC4_RS14020	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC4_RS14025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC4_RS14030	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC4_RS14035	COG0330	HflC and HflK could
FORC4_RS14040	COG0330	HflC and HflK could
FORC4_RS14045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC4_RS14055	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC4_RS14060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC4_RS14070	COG0802	atpase or kinase
FORC4_RS14075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC4_RS14145	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC4_RS14150	COG1162	GTPase activity
FORC4_RS14155	COG0688	phosphatidylethanolamine metabolic process
FORC4_RS14160	COG0471	metal ion transport
FORC4_RS14175	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC4_RS14180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC4_RS14185	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC4_RS14190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC4_RS14195	COG1045	serine acetyltransferase
FORC4_RS14200	COG4942	peptidase
FORC4_RS14220	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC4_RS14225	COG1053	succinate dehydrogenase
FORC4_RS14230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC4_RS14235	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC4_RS14240	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC4_RS14250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC4_RS14255	COG1509	lysine 2,3-aminomutase activity
FORC4_RS14260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC4_RS14280	COG0459	protein refolding
FORC4_RS14290	COG0534	Mate efflux family protein
FORC4_RS14295	COG0205	6-phosphofructokinase activity
FORC4_RS14305	COG3678	ATP-independent chaperone mediated protein folding
FORC4_RS14310	COG0745	RESPONSE REGULATOR receiver
FORC4_RS14315	COG2205	protein histidine kinase activity
FORC4_RS14325	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC4_RS14330	COG3030	protein affecting phage T7 exclusion by the F plasmid
FORC4_RS14335	COG1027	Aspartate ammonia-lyase
FORC4_RS14340	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC4_RS14345	COG4232	protein-disulfide reductase activity
FORC4_RS14355	COG3263	regulation of cellular component size
FORC4_RS14365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC4_RS14385	COG2205	protein histidine kinase activity
FORC4_RS14385	COG0784	Response regulator, receiver
FORC4_RS14385	COG2198	Histidine kinase
FORC4_RS14390	COG2814	Major facilitator Superfamily
FORC4_RS14405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC4_RS14410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC4_RS14415	COG0511	ligase activity, forming carbon-carbon bonds
FORC4_RS14420	COG0439	Biotin carboxylase
FORC4_RS14425	COG2264	protein methyltransferase activity
FORC4_RS14430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC4_RS14435	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC4_RS14440	COG2814	Major facilitator Superfamily
FORC4_RS14445	COG0488	(ABC) transporter
FORC4_RS14450	COG3706	GGDEF domain
FORC4_RS14515	COG1982	Orn Lys Arg decarboxylase major
FORC4_RS14520	COG0531	amino acid
FORC4_RS14525	COG3710	Transcriptional regulator
FORC4_RS14530	COG0789	Transcriptional regulator
FORC4_RS14535	COG0138	bifunctional purine biosynthesis protein purh
FORC4_RS14540	COG0151	Belongs to the GarS family
FORC4_RS14555	COG1253	flavin adenine dinucleotide binding
FORC4_RS14565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC4_RS14570	COG1573	uracil-dna glycosylase
FORC4_RS14575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC4_RS14590	COG2816	NAD+ diphosphatase activity
FORC4_RS14595	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC4_RS14600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC4_RS14605	COG0085	RNA polymerase activity
FORC4_RS14610	COG0222	ribosome binding
FORC4_RS14615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC4_RS14620	COG0081	regulation of translation
FORC4_RS14625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC4_RS14630	COG0250	Participates in transcription elongation, termination and antitermination
FORC4_RS14635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC4_RS14640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC4_RS14675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC4_RS14685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC4_RS14740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC4_RS14750	COG4206	TonB-dependent receptor
FORC4_RS14770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC4_RS14775	COG0534	Mate efflux family protein
FORC4_RS14780	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC4_RS14785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC4_RS14790	COG2937	Belongs to the GPAT DAPAT family
FORC4_RS14795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC4_RS14800	COG3161	chorismate lyase activity
FORC4_RS14805	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC4_RS14810	COG0705	Rhomboid family
FORC4_RS14815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC4_RS14825	COG2177	Part of the ABC transporter FtsEX involved in
FORC4_RS14830	COG2884	Cell division ATP-binding protein ftsE
FORC4_RS14835	COG0552	protein localization to endoplasmic reticulum
FORC4_RS14840	COG0742	ribosomal rna small subunit methyltransferase
FORC4_RS14850	COG2095	MarC family integral membrane protein
FORC4_RS14900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC4_RS14905	COG0640	Transcriptional regulator
FORC4_RS14910	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC4_RS14915	COG1280	lysine exporter protein (LysE YggA)
FORC4_RS14920	COG2267	carboxylic ester hydrolase activity
FORC4_RS14925	COG0561	phosphatase activity
FORC4_RS14940	COG3148	PFAM DTW domain containing protein
FORC4_RS14945	COG2200	EAL domain
FORC4_RS14945	COG2199	diguanylate cyclase activity
FORC4_RS14945	COG3287	FIST C domain
FORC4_RS14950	COG1011	Hydrolase
FORC4_RS14955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC4_RS14965	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC4_RS14970	COG0019	diaminopimelate decarboxylase activity
FORC4_RS14980	COG1965	Belongs to the frataxin family
FORC4_RS14985	COG3072	Adenylate cyclase
FORC4_RS14990	COG0181	hydroxymethylbilane synthase activity
FORC4_RS14995	COG1587	Uroporphyrinogen-III synthase
FORC4_RS15000	COG2959	enzyme of heme biosynthesis
FORC4_RS15005	COG3071	HemY protein
FORC4_RS15045	COG0633	Ferredoxin
FORC4_RS15050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC4_RS15065	COG3118	belongs to the thioredoxin family
FORC4_RS15070	COG0513	Belongs to the DEAD box helicase family
FORC4_RS15075	COG0248	Ppx GppA phosphatase
FORC4_RS15080	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC4_RS15090	COG0514	ATP-dependent DNA helicase (RecQ)
FORC4_RS15095	COG2962	Rard protein
FORC4_RS15105	COG1280	lysine exporter protein (LysE YggA)
FORC4_RS15110	COG0405	Gamma-glutamyltransferase
FORC4_RS15115	COG0210	DNA helicase
FORC4_RS15125	COG3220	belongs to the UPF0276 family
FORC4_RS15155	COG0006	proline dipeptidase activity
FORC4_RS15155	COG0006	proline dipeptidase activity
FORC4_RS15165	COG2022	thiamine diphosphate biosynthetic process
FORC4_RS15170	COG2104	thiamine diphosphate biosynthetic process
FORC4_RS15175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC4_RS15180	COG0352	thiamine-phosphate diphosphorylase activity
FORC4_RS15185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC4_RS15190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC4_RS15240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC4_RS15250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC4_RS15255	COG0408	coproporphyrinogen oxidase activity
FORC4_RS15260	COG0009	L-threonylcarbamoyladenylate synthase
FORC4_RS15265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC4_RS15270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC4_RS15275	COG0551	DNA topoisomerase type I activity
FORC4_RS15280	COG2922	Belongs to the Smg family
FORC4_RS15285	COG0758	DNA mediated transformation
FORC4_RS15295	COG0242	peptide deformylase activity
FORC4_RS15300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC4_RS15305	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC4_RS15305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC4_RS15310	COG0569	domain protein
FORC4_RS15315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC4_RS15325	COG1272	protein, Hemolysin III
FORC4_RS15330	COG4326	sporulation control protein
FORC4_RS15335	COG3084	Protein conserved in bacteria
FORC4_RS15345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC4_RS15350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC4_RS15355	COG0204	Acyl-transferase
FORC4_RS15365	COG0606	chelatase, subunit chli
FORC4_RS15375	COG3978	acetolactate synthase activity
FORC4_RS15380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC4_RS15385	COG0129	dihydroxy-acid dehydratase activity
FORC4_RS15395	COG0583	DNA-binding transcription factor activity
FORC4_RS15400	COG2814	Major facilitator Superfamily
FORC4_RS15405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_RS15410	COG0765	amino acid transport
FORC4_RS15415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC4_RS15420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC4_RS15425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC4_RS15430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORC4_RS15435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC4_RS15440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC4_RS15455	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC4_RS15460	COG3312	ion transport
FORC4_RS15465	COG1475	DNA binding
FORC4_RS15470	COG1192	Involved in chromosome partitioning
FORC4_RS15475	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC4_RS15480	COG0445	tRNA wobble uridine modification
FORC4_RS15505	COG4608	Belongs to the ABC transporter superfamily
FORC4_RS15510	COG0444	Belongs to the ABC transporter superfamily
FORC4_RS15545	COG0217	transcriptional regulatory protein
FORC4_RS15550	COG0772	Belongs to the SEDS family
FORC4_RS15560	COG1136	(ABC) transporter
FORC4_RS15580	COG3275	phosphorelay sensor kinase activity
FORC4_RS15585	COG3279	Response regulator of the LytR AlgR family
FORC4_RS15595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC4_RS15620	COG0786	glutamate:sodium symporter activity
FORC4_RS15630	COG1131	(ABC) transporter
FORC4_RS15635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_RS15640	COG0786	glutamate:sodium symporter activity
FORC4_RS15650	COG0363	glucosamine-6-phosphate deaminase activity
FORC4_RS15670	COG1741	Belongs to the pirin family
FORC4_RS15675	COG2259	Doxx family
FORC4_RS15685	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FORC4_RS15690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC4_RS15700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC4_RS15740	COG3123	guanosine phosphorylase activity
FORC4_RS15750	COG5001	Diguanylate cyclase
FORC4_RS15755	COG0534	Mate efflux family protein
FORC4_RS15760	COG0564	pseudouridine synthase activity
FORC4_RS15775	COG0583	DNA-binding transcription factor activity
FORC4_RS15780	COG0561	phosphatase activity
FORC4_RS15790	COG2199	diguanylate cyclase activity
FORC4_RS15805	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FORC4_RS15810	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FORC4_RS15815	COG0583	DNA-binding transcription factor activity
FORC4_RS15830	COG1414	Transcriptional regulator
FORC4_RS15835	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS15845	COG1917	Cupin 2, conserved barrel domain protein
FORC4_RS15860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC4_RS15865	COG0800	Aldolase
FORC4_RS15885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC4_RS15890	COG0823	Involved in the tonB-independent uptake of proteins
FORC4_RS15895	COG2375	cellular response to nickel ion
FORC4_RS15925	COG1357	PFAM Pentapeptide repeats (8 copies)
FORC4_RS15930	COG3047	cAMP biosynthetic process
FORC4_RS15960	COG3408	Glycogen debranching enzyme
FORC4_RS15960	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FORC4_RS15965	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FORC4_RS15975	COG0583	DNA-binding transcription factor activity
FORC4_RS15985	COG0583	DNA-binding transcription factor activity
FORC4_RS16015	COG3835	regulator
FORC4_RS16025	COG1929	Belongs to the glycerate kinase type-1 family
FORC4_RS16030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_RS16050	COG0456	acetyltransferase
FORC4_RS16065	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS16075	COG3005	denitrification pathway
FORC4_RS16080	COG0243	molybdopterin cofactor binding
FORC4_RS16090	COG0352	thiamine-phosphate diphosphorylase activity
FORC4_RS16095	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FORC4_RS16100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FORC4_RS16105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC4_RS16110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC4_RS16115	COG1116	anion transmembrane transporter activity
FORC4_RS16120	COG0351	phosphomethylpyrimidine kinase
FORC4_RS16125	COG0312	modulator of DNA gyrase
FORC4_RS16130	COG0312	modulator of DNA gyrase
FORC4_RS16135	COG1901	pseudouridine methyltransferase
FORC4_RS16190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC4_RS16200	COG0584	glycerophosphoryl diester phosphodiesterase
FORC4_RS16205	COG0039	L-malate dehydrogenase activity
FORC4_RS16210	COG0745	RESPONSE REGULATOR receiver
FORC4_RS16230	COG0811	peptide transport
FORC4_RS16235	COG0811	peptide transport
FORC4_RS16240	COG0848	biopolymer transport protein
FORC4_RS16280	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC4_RS16285	COG1121	(ABC) transporter
FORC4_RS16290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC4_RS16305	COG1770	oligopeptidase
FORC4_RS16310	COG2814	Major facilitator Superfamily
FORC4_RS16315	COG0010	Belongs to the arginase family
FORC4_RS16320	COG1166	arginine decarboxylase activity
FORC4_RS16330	COG0189	ligase activity
FORC4_RS16330	COG4067	protein conserved in archaea
FORC4_RS16335	COG0189	ligase activity
FORC4_RS16345	COG0583	DNA-binding transcription factor activity
FORC4_RS16380	COG2204	response regulator
FORC4_RS16385	COG2199	diguanylate cyclase activity
FORC4_RS16405	COG0579	oxidoreductase
FORC4_RS16415	COG3033	Beta-eliminating lyase
FORC4_RS16430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC4_RS16445	COG3706	GGDEF domain
FORC4_RS16450	COG0840	transmembrane signaling receptor activity
FORC4_RS16465	COG3706	GGDEF domain
FORC4_RS16470	COG0415	Belongs to the DNA photolyase family
FORC4_RS16475	COG3046	protein related to deoxyribodipyrimidine photolyase
FORC4_RS16485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC4_RS16485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC4_RS16490	COG1765	OsmC-like protein
FORC4_RS16495	COG0110	maltose O-acetyltransferase activity
FORC4_RS16535	COG1011	Hydrolase
FORC4_RS16550	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC4_RS16560	COG2067	long-chain fatty acid transport protein
FORC4_RS16570	COG1136	(ABC) transporter
FORC4_RS16570	COG0577	efflux transmembrane transporter activity
FORC4_RS16580	COG3240	lipase activity
FORC4_RS16610	COG1609	Transcriptional regulator
FORC4_RS16615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC4_RS16620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC4_RS16625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC4_RS16630	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC4_RS16640	COG3842	ATPase activity
FORC4_RS16665	COG2990	Protein conserved in bacteria
FORC4_RS16670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC4_RS16675	COG2866	Carboxypeptidase
FORC4_RS16685	COG0583	DNA-binding transcription factor activity
FORC4_RS16705	COG3104	oligopeptide transport
FORC4_RS16710	COG1760	l-serine dehydratase
FORC4_RS16735	COG0741	lytic transglycosylase activity
FORC4_RS16755	COG1815	bacterial-type flagellum-dependent cell motility
FORC4_RS16760	COG1558	bacterial-type flagellum-dependent cell motility
FORC4_RS16765	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC4_RS16770	COG1749	Flagellar hook protein flgE
FORC4_RS16775	COG4787	bacterial-type flagellum-dependent cell motility
FORC4_RS16780	COG4786	Flagellar basal body rod
FORC4_RS16785	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC4_RS16790	COG1706	bacterial-type flagellum-dependent cell motility
FORC4_RS16805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_RS16825	COG1304	FMN binding
FORC4_RS16850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC4_RS16855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC4_RS16860	COG0459	protein refolding
FORC4_RS16870	COG1280	lysine exporter protein (LysE YggA)
FORC4_RS16890	COG1309	transcriptional regulator
FORC4_RS16900	COG0737	Belongs to the 5'-nucleotidase family
FORC4_RS16905	COG2070	2-Nitropropane dioxygenase
FORC4_RS16910	COG3537	Alpha-1,2-mannosidase
FORC4_RS16915	COG3537	Alpha-1,2-mannosidase
FORC4_RS16925	COG3537	Alpha-1,2-mannosidase
FORC4_RS16930	COG3537	Alpha-1,2-mannosidase
FORC4_RS16935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_RS16955	COG0346	lactoylglutathione lyase activity
FORC4_RS16960	COG1349	DNA-binding transcription factor activity
FORC4_RS16970	COG0753	catalase activity
FORC4_RS16980	COG1335	isochorismatase
FORC4_RS16990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC4_RS17015	COG0583	DNA-binding transcription factor activity
FORC4_RS17030	COG3713	MltA-interacting MipA family protein
FORC4_RS17035	COG3015	lipoprotein NlpE involved in copper resistance
FORC4_RS17040	COG1342	Belongs to the UPF0251 family
FORC4_RS17070	COG4948	Mandelate Racemase Muconate Lactonizing
FORC4_RS17080	COG0583	DNA-binding transcription factor activity
FORC4_RS17120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC4_RS17160	COG3842	ATPase activity
FORC4_RS17190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC4_RS17210	COG3706	GGDEF domain
FORC4_RS17230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_RS17250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC4_RS17265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC4_RS17265	COG0574	Belongs to the PEP-utilizing enzyme family
FORC4_RS17270	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FORC4_RS17275	COG0252	asparaginase activity
FORC4_RS17280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC4_RS17285	COG0583	DNA-binding transcription factor activity
FORC4_RS17305	COG3122	Protein conserved in bacteria
FORC4_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS17325	COG1063	alcohol dehydrogenase
FORC4_RS17330	COG1902	pentaerythritol trinitrate reductase activity
FORC4_RS17345	COG0583	DNA-binding transcription factor activity
FORC4_RS17355	COG0513	Belongs to the DEAD box helicase family
FORC4_RS17395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_RS17400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC4_RS17400	COG2207	Transcriptional regulator
FORC4_RS17465	COG2354	Protein conserved in bacteria
FORC4_RS17470	COG0418	dihydroorotase activity
FORC4_RS17475	COG3217	Mosc domain protein beta barrel domain protein
FORC4_RS17475	COG0633	Ferredoxin
FORC4_RS17475	COG0633	Ferredoxin
FORC4_RS17475	COG3217	Mosc domain protein beta barrel domain protein
FORC4_RS17480	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC4_RS17485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORC4_RS17530	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC4_RS17535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC4_RS17545	COG0848	biopolymer transport protein
FORC4_RS17550	COG0811	peptide transport
FORC4_RS17555	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC4_RS17565	COG3721	Heme iron utilization protein
FORC4_RS17570	COG0748	coenzyme F420 binding
FORC4_RS17580	COG0835	chemotaxis
FORC4_RS17580	COG0784	Response regulator, receiver
FORC4_RS17585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC4_RS17645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC4_RS17650	COG0783	Belongs to the Dps family
FORC4_RS17655	COG0583	DNA-binding transcription factor activity
FORC4_RS17670	COG4934	collagen metabolic process
FORC4_RS17680	COG0366	Alpha amylase catalytic
FORC4_RS17700	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC4_RS17705	COG0589	response to stress
FORC4_RS17710	COG0488	(ABC) transporter
FORC4_RS17715	COG1505	serine-type exopeptidase activity
FORC4_RS17725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_RS17735	COG2067	long-chain fatty acid transport protein
FORC4_RS17745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC4_RS17770	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_RS17790	COG3383	formate dehydrogenase (NAD+) activity
FORC4_RS17805	COG0842	Transport permease protein
FORC4_RS17810	COG1131	(ABC) transporter
FORC4_RS17825	COG2706	6-phosphogluconolactonase activity
FORC4_RS17835	COG1881	PFAM PEBP family protein
FORC4_RS17845	COG0798	PFAM Bile acid sodium symporter
FORC4_RS17860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_RS17865	COG2213	PTS system mannitol-specific
FORC4_RS17870	COG1063	alcohol dehydrogenase
FORC4_RS17880	COG1072	(Pantothenic acid kinase))
FORC4_RS17885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC4_RS17905	COG0814	amino acid
FORC4_RS17920	COG3314	Sporulation integral membrane protein YlbJ
FORC4_RS17940	COG0739	heme binding
FORC4_RS17945	COG5001	Diguanylate cyclase
FORC4_RS17950	COG0583	DNA-binding transcription factor activity
FORC4_RS17955	COG2814	Major facilitator Superfamily
FORC4_RS17970	COG0697	spore germination
FORC4_RS18000	COG2207	Transcriptional regulator
FORC4_RS18005	COG1280	lysine exporter protein (LysE YggA)
FORC4_RS18015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC4_RS18020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC4_RS18030	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FORC4_RS18055	COG1612	heme a metabolic process
FORC4_RS18060	COG0109	protoheme IX farnesyltransferase activity
FORC4_RS18065	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC4_RS18095	COG1278	Cold shock
FORC4_RS18100	COG3036	rescue of stalled ribosome
FORC4_RS18130	COG1136	(ABC) transporter
FORC4_RS18130	COG0577	efflux transmembrane transporter activity
FORC4_RS18140	COG0840	transmembrane signaling receptor activity
FORC4_RS18145	COG0783	Belongs to the Dps family
FORC4_RS18155	COG2133	pyrroloquinoline quinone binding
FORC4_RS18160	COG1454	alcohol dehydrogenase
FORC4_RS18165	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FORC4_RS18195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC4_RS18200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC4_RS18205	COG3186	Phenylalanine-4-hydroxylase
FORC4_RS18210	COG2154	pterin-4-alpha-carbinolamine dehydratase
FORC4_RS18230	COG3530	Putative quorum-sensing-regulated virulence factor
FORC4_RS18235	COG0513	Belongs to the DEAD box helicase family
FORC4_RS18240	COG4628	conserved protein (DUF2132)
FORC4_RS18245	COG0133	tryptophan synthase activity
FORC4_RS18255	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FORC4_RS18265	COG0523	cobalamin synthesis protein
FORC4_RS18270	COG0513	Belongs to the DEAD box helicase family
FORC4_RS18290	COG2200	EAL domain
FORC4_RS18295	COG1119	ATPase activity
FORC4_RS18300	COG0840	transmembrane signaling receptor activity
FORC4_RS18315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC4_RS18330	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FORC4_RS18335	COG0513	Belongs to the DEAD box helicase family
FORC4_RS18340	COG5001	Diguanylate cyclase
FORC4_RS18345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC4_RS18360	COG5413	integral membrane protein
FORC4_RS18370	COG1024	Enoyl-CoA hydratase
FORC4_RS18375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC4_RS18380	COG1960	acyl-CoA dehydrogenase activity
FORC4_RS18390	COG0183	Belongs to the thiolase family
FORC4_RS18405	COG1024	Enoyl-CoA hydratase
FORC4_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS18425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC4_RS18430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORC4_RS18435	COG1845	cytochrome c oxidase, subunit III
FORC4_RS18440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FORC4_RS18445	COG0109	protoheme IX farnesyltransferase activity
FORC4_RS18460	COG1902	pentaerythritol trinitrate reductase activity
FORC4_RS18490	COG1126	abc transporter atp-binding protein
FORC4_RS18495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_RS18500	COG4215	(ABC) transporter
FORC4_RS18505	COG4160	amino acid transport
FORC4_RS18520	COG0625	glutathione transferase activity
FORC4_RS18555	COG0443	Heat shock 70 kDa protein
FORC4_RS18560	COG2847	Copper chaperone PCu(A)C
FORC4_RS18580	COG4607	ABC-type enterochelin transport system periplasmic component
FORC4_RS18585	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC4_RS18590	COG4605	iron ion homeostasis
FORC4_RS18595	COG4604	ABC transporter, ATP-binding protein
FORC4_RS18600	COG0789	Transcriptional regulator
FORC4_RS18610	COG4771	TonB-dependent receptor
FORC4_RS18610	COG1629	transport
FORC4_RS18640	COG1289	transmembrane transporter activity
FORC4_RS18645	COG0210	DNA helicase
FORC4_RS18650	COG1803	Methylglyoxal synthase
FORC4_RS18655	COG1879	ABC-type sugar transport system periplasmic component
FORC4_RS18660	COG2205	protein histidine kinase activity
FORC4_RS18660	COG0784	Response regulator, receiver
FORC4_RS18660	COG2198	Histidine kinase
FORC4_RS18675	COG0745	RESPONSE REGULATOR receiver
FORC4_RS18685	COG3119	arylsulfatase activity
FORC4_RS18690	COG3119	arylsulfatase activity
FORC4_RS18705	COG3119	arylsulfatase activity
FORC4_RS18710	COG0641	radical SAM
FORC4_RS18715	COG0714	Associated with various cellular activities
FORC4_RS18745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC4_RS18745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC4_RS18750	COG0583	DNA-binding transcription factor activity
FORC4_RS18755	COG1597	lipid kinase activity
FORC4_RS18760	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC4_RS18775	COG0641	radical SAM
FORC4_RS18800	COG0501	Belongs to the peptidase M48B family
FORC4_RS18805	COG1704	LemA family
FORC4_RS18810	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC4_RS18820	COG1214	PFAM Peptidase M22, glycoprotease
FORC4_RS18820	COG0456	acetyltransferase
FORC4_RS18840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FORC4_RS18860	COG2207	Transcriptional regulator
FORC4_RS18885	COG4964	Belongs to the GSP D family
FORC4_RS18960	COG5001	Diguanylate cyclase
FORC4_RS18960	COG3300	MHYT domain
FORC4_RS18965	COG2197	response regulator
FORC4_RS18970	COG3706	GGDEF domain
FORC4_RS18980	COG2197	response regulator
FORC4_RS18995	COG0784	Response regulator, receiver
FORC4_RS18995	COG0835	chemotaxis
FORC4_RS19010	COG2962	Rard protein
FORC4_RS19020	COG0671	phosphoesterase, PA-phosphatase related
FORC4_RS19035	COG2076	Multidrug Resistance protein
FORC4_RS19065	COG0471	metal ion transport
FORC4_RS19070	COG3290	protein histidine kinase activity
FORC4_RS19075	COG4565	transcriptional regulatory protein
FORC4_RS19090	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC4_RS19095	COG5642	Protein of unknown function (DUF2384)
FORC4_RS19115	COG1902	pentaerythritol trinitrate reductase activity
FORC4_RS19120	COG0346	lactoylglutathione lyase activity
FORC4_RS19140	COG2239	Acts as a magnesium transporter
FORC4_RS19165	COG0242	peptide deformylase activity
FORC4_RS19205	COG2176	DNA-directed DNA polymerase activity
FORC4_RS19210	COG0583	DNA-binding transcription factor activity
FORC4_RS19215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC4_RS19220	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC4_RS19260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC4_RS19260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC4_RS19265	COG0509	glycine decarboxylation via glycine cleavage system
FORC4_RS19270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC4_RS19310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_RS19310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_RS19310	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FORC4_RS19315	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC4_RS19320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_RS19320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_RS19325	COG1609	Transcriptional regulator
FORC4_RS19340	COG2199	diguanylate cyclase activity
FORC4_RS19340	COG2203	Gaf domain
FORC4_RS19340	COG2200	EAL domain
FORC4_RS19345	COG0765	amino acid transport
FORC4_RS19350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_RS19355	COG0765	amino acid transport
FORC4_RS19360	COG1126	abc transporter atp-binding protein
FORC4_RS19365	COG0469	pyruvate kinase activity
FORC4_RS19370	COG2271	Major facilitator Superfamily
FORC4_RS19395	COG1979	alcohol dehydrogenase
FORC4_RS19400	COG2207	Transcriptional regulator
FORC4_RS19410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC4_RS19415	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FORC4_RS19420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC4_RS19435	COG0784	Response regulator, receiver
FORC4_RS19435	COG3437	response regulator, receiver
FORC4_RS19440	COG0546	phosphoglycolate phosphatase activity
FORC4_RS19445	COG0840	transmembrane signaling receptor activity
FORC4_RS19450	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FORC4_RS19455	COG0513	Belongs to the DEAD box helicase family
FORC4_RS19460	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FORC4_RS19475	COG3038	cytochrome b561
FORC4_RS19480	COG2353	YceI-like domain
FORC4_RS19485	COG2116	formate transmembrane transporter activity
FORC4_RS19490	COG0583	DNA-binding transcription factor activity
FORC4_RS19500	COG3593	DNA synthesis involved in DNA repair
FORC4_RS19505	COG0737	Belongs to the 5'-nucleotidase family
FORC4_RS19510	COG0861	Integral membrane protein TerC family
FORC4_RS19525	COG2267	carboxylic ester hydrolase activity
FORC4_RS19530	COG2067	long-chain fatty acid transport protein
FORC4_RS19545	COG2050	protein possibly involved in aromatic compounds catabolism
FORC4_RS19555	COG4533	DNA binding
FORC4_RS19580	COG0484	heat shock protein binding
FORC4_RS19590	COG5001	Diguanylate cyclase
FORC4_RS19590	COG3300	MHYT domain
FORC4_RS19595	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC4_RS19605	COG4181	ATPase activity
FORC4_RS19610	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FORC4_RS19620	COG1984	allophanate hydrolase subunit 2
FORC4_RS19625	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC4_RS19630	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC4_RS19635	COG5001	Diguanylate cyclase
FORC4_RS19635	COG5002	protein histidine kinase activity
FORC4_RS19635	COG3447	MASE1 domain protein
FORC4_RS19640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC4_RS19645	COG4771	TonB-dependent receptor
FORC4_RS19645	COG1629	transport
FORC4_RS19650	COG0583	DNA-binding transcription factor activity
FORC4_RS19655	COG1042	CoA-binding domain protein
FORC4_RS19655	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC4_RS19655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC4_RS19665	COG1181	Belongs to the D-alanine--D-alanine ligase family
FORC4_RS19675	COG0023	Translation Initiation Factor
FORC4_RS19685	COG0583	DNA-binding transcription factor activity
FORC4_RS19695	COG0589	response to stress
FORC4_RS19720	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FORC4_RS19725	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FORC4_RS19750	COG5001	Diguanylate cyclase
FORC4_RS19750	COG3706	GGDEF domain
FORC4_RS19750	COG4251	negative regulation of phosphorylation
FORC4_RS19750	COG2203	Gaf domain
FORC4_RS19760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FORC4_RS19765	COG4149	molybdate abc transporter
FORC4_RS19770	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC4_RS19775	COG1492	cobalamin metabolic process
FORC4_RS19780	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC4_RS19790	COG0189	ligase activity
FORC4_RS19790	COG4067	protein conserved in archaea
FORC4_RS19805	COG0534	Mate efflux family protein
FORC4_RS19810	COG0602	queuosine metabolic process
FORC4_RS19815	COG1328	CTP reductase activity
FORC4_RS19830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_RS19860	COG0243	molybdopterin cofactor binding
FORC4_RS19865	COG0583	DNA-binding transcription factor activity
FORC4_RS19870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC4_RS19880	COG2197	response regulator
FORC4_RS19885	COG3851	Histidine kinase
FORC4_RS19890	COG2271	Major facilitator Superfamily
FORC4_RS19915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC4_RS19920	COG3118	belongs to the thioredoxin family
FORC4_RS19930	COG2205	protein histidine kinase activity
FORC4_RS19930	COG3292	Two component regulator propeller
FORC4_RS19930	COG0745	RESPONSE REGULATOR receiver
FORC4_RS19935	COG0534	Mate efflux family protein
FORC4_RS19970	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC4_RS19990	COG2116	formate transmembrane transporter activity
FORC4_RS20000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC4_RS20005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC4_RS20045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC4_RS20045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC4_RS20085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC4_RS20100	COG0277	FAD linked oxidase domain protein
FORC4_RS20105	COG0583	DNA-binding transcription factor activity
FORC4_RS20120	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FORC4_RS20135	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC4_RS20145	COG1288	antiporter activity
FORC4_RS20155	COG2814	Major facilitator Superfamily
FORC4_RS20165	COG3040	lipid binding
FORC4_RS20185	COG0419	ATPase involved in DNA repair
FORC4_RS20190	COG0420	3'-5' exonuclease activity
FORC4_RS20260	COG0631	protein serine/threonine phosphatase activity
FORC4_RS20300	COG0515	serine threonine protein kinase
FORC4_RS20300	COG2815	serine threonine protein kinase
FORC4_RS20355	COG2146	nitrite reductase [NAD(P)H] activity
FORC4_RS20355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC4_RS20360	COG1116	anion transmembrane transporter activity
FORC4_RS20365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC4_RS20370	COG1116	anion transmembrane transporter activity
FORC4_RS20370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC4_RS20375	COG3707	response regulator
FORC4_RS20390	COG1648	precorrin-2 dehydrogenase activity
FORC4_RS20390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC4_RS20395	COG0243	molybdopterin cofactor binding
FORC4_RS20405	COG0814	amino acid
FORC4_RS20430	COG1785	Belongs to the alkaline phosphatase family
FORC4_RS20445	COG0745	RESPONSE REGULATOR receiver
FORC4_RS20465	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FORC4_RS20480	COG1609	Transcriptional regulator
FORC4_RS20485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC4_RS20490	COG1879	ABC-type sugar transport system periplasmic component
FORC4_RS20495	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC4_RS20500	COG1129	ABC transporter
FORC4_RS20505	COG1869	D-ribose catabolic process
FORC4_RS20510	COG5001	Diguanylate cyclase
FORC4_RS20515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC4_RS20570	COG0784	Response regulator, receiver
FORC4_RS20570	COG2205	protein histidine kinase activity
FORC4_RS20580	COG3300	MHYT domain
FORC4_RS20580	COG5001	Diguanylate cyclase
FORC4_RS20590	COG0330	HflC and HflK could
FORC4_RS20605	COG0517	IMP dehydrogenase activity
FORC4_RS20605	COG4175	Glycine betaine
FORC4_RS20610	COG4176	ABC-type proline glycine betaine transport system permease component
FORC4_RS20625	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_RS20630	COG1309	transcriptional regulator
FORC4_RS20635	COG3706	GGDEF domain
FORC4_RS20640	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS20655	COG1024	Enoyl-CoA hydratase
FORC4_RS20660	COG1960	acyl-CoA dehydrogenase activity
FORC4_RS20670	COG0183	Belongs to the thiolase family
FORC4_RS20680	COG1960	acyl-CoA dehydrogenase activity
FORC4_RS20685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC4_RS20695	COG4770	biotin carboxylase activity
FORC4_RS20705	COG3437	response regulator, receiver
FORC4_RS20705	COG4999	Histidine kinase
FORC4_RS20705	COG2205	protein histidine kinase activity
FORC4_RS20705	COG3850	Histidine kinase
FORC4_RS20720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC4_RS20720	COG3264	Mechanosensitive ion channel
FORC4_RS20725	COG0110	maltose O-acetyltransferase activity
FORC4_RS20730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_RS20735	COG1271	oxidase subunit
FORC4_RS20740	COG1294	oxidase, subunit
FORC4_RS20745	COG0384	phenazine biosynthesis protein PhzF
FORC4_RS20750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC4_RS20755	COG0789	Transcriptional regulator
FORC4_RS20765	COG3474	cytochrome
FORC4_RS20770	COG1013	pyruvate-flavodoxin oxidoreductase activity
FORC4_RS20775	COG0674	pyruvate-flavodoxin oxidoreductase activity
FORC4_RS20775	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FORC4_RS20840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC4_RS20845	COG0516	GMP reductase activity
FORC4_RS20850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC4_RS20850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC4_RS20865	COG4989	oxidoreductase activity
FORC4_RS20880	COG0038	chloride channel
FORC4_RS20890	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC4_RS20895	COG0302	gtp cyclohydrolase
FORC4_RS20905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC4_RS20925	COG2897	thiosulfate sulfurtransferase activity
FORC4_RS20950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC4_RS20955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC4_RS20960	COG0840	transmembrane signaling receptor activity
FORC4_RS20965	COG2814	Major facilitator Superfamily
FORC4_RS20970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC4_RS20980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC4_RS20990	COG0840	transmembrane signaling receptor activity
FORC4_RS21010	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC4_RS21025	COG2197	response regulator
FORC4_RS21030	COG3850	Histidine kinase
FORC4_RS21040	COG0243	molybdopterin cofactor binding
FORC4_RS21050	COG3005	denitrification pathway
FORC4_RS21065	COG0183	Belongs to the thiolase family
FORC4_RS21075	COG1280	lysine exporter protein (LysE YggA)
FORC4_RS21085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC4_RS21090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC4_RS21115	COG1522	sequence-specific DNA binding
FORC4_RS21135	COG1566	PFAM secretion protein HlyD family protein
FORC4_RS21145	COG2205	protein histidine kinase activity
FORC4_RS21145	COG0784	Response regulator, receiver
FORC4_RS21150	COG1879	ABC-type sugar transport system periplasmic component
FORC4_RS21155	COG2827	Endonuclease containing a URI domain
FORC4_RS21160	COG3132	Protein of unknown function, DUF480
FORC4_RS21170	COG2926	Belongs to the UPF0265 family
FORC4_RS21175	COG0534	Mate efflux family protein
FORC4_RS21180	COG0673	inositol 2-dehydrogenase activity
FORC4_RS21215	COG0531	amino acid
FORC4_RS21230	COG2205	protein histidine kinase activity
FORC4_RS21235	COG0745	RESPONSE REGULATOR receiver
FORC4_RS21260	COG1566	PFAM secretion protein HlyD family protein
FORC4_RS21265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC4_RS21270	COG2239	Acts as a magnesium transporter
FORC4_RS21275	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FORC4_RS21280	COG0402	S-adenosylhomocysteine deaminase activity
FORC4_RS21290	COG1418	mRNA catabolic process
FORC4_RS21300	COG2814	Major facilitator Superfamily
FORC4_RS21310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC4_RS21330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC4_RS21345	COG4221	oxidoreductase activity
FORC4_RS21350	COG0745	RESPONSE REGULATOR receiver
FORC4_RS21355	COG2205	protein histidine kinase activity
FORC4_RS21365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC4_RS21370	COG2194	sulfuric ester hydrolase activity
FORC4_RS21375	COG0673	inositol 2-dehydrogenase activity
FORC4_RS21405	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC4_RS21410	COG1741	Belongs to the pirin family
FORC4_RS21415	COG1278	Cold shock
FORC4_RS21425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC4_RS21430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC4_RS21430	COG0678	peroxiredoxin activity
FORC4_RS21445	COG1686	Belongs to the peptidase S11 family
FORC4_RS21450	COG0625	glutathione transferase activity
FORC4_RS21460	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORC4_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS21500	COG3746	phosphate-selective porin O and P
FORC4_RS21520	COG3833	ABC-type maltose transport systems, permease component
FORC4_RS21525	COG1175	transmembrane transport
FORC4_RS21535	COG3842	ATPase activity
FORC4_RS21540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC4_RS21595	COG3097	Belongs to the UPF0267 family
FORC4_RS21600	COG1309	transcriptional regulator
FORC4_RS21605	COG2130	NADP-dependent
FORC4_RS21615	COG0753	catalase activity
FORC4_RS21620	COG2084	Dehydrogenase
FORC4_RS21625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_RS21630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_RS21640	COG2207	Transcriptional regulator
FORC4_RS21645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_RS21645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_RS21645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_RS21660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC4_RS21665	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FORC4_RS21670	COG3300	MHYT domain
FORC4_RS21670	COG5001	Diguanylate cyclase
FORC4_RS21675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC4_RS21680	COG0569	domain protein
FORC4_RS21690	COG2205	protein histidine kinase activity
FORC4_RS21695	COG1132	(ABC) transporter
FORC4_RS21700	COG4774	siderophore transport
FORC4_RS21705	COG1120	ATPase activity
FORC4_RS21710	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC4_RS21760	COG2197	response regulator
FORC4_RS21770	COG0840	transmembrane signaling receptor activity
FORC4_RS21775	COG0714	Associated with various cellular activities
FORC4_RS21795	COG2304	oxidoreductase activity
FORC4_RS21810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC4_RS21815	COG0581	inorganic phosphate transmembrane transporter activity
FORC4_RS21820	COG0573	inorganic phosphate transmembrane transporter activity
FORC4_RS21855	COG1770	oligopeptidase
FORC4_RS21860	COG0513	Belongs to the DEAD box helicase family
FORC4_RS21870	COG1388	LysM domain
FORC4_RS21870	COG1376	ErfK ybiS ycfS ynhG family protein
FORC4_RS21875	COG0415	Belongs to the DNA photolyase family
FORC4_RS21880	COG0789	Transcriptional regulator
FORC4_RS21885	COG3272	Protein of unknown function (DUF1722)
FORC4_RS21890	COG0813	purine-nucleoside phosphorylase activity
FORC4_RS21905	COG3706	GGDEF domain
FORC4_RS21915	COG1566	PFAM secretion protein HlyD family protein
FORC4_RS21920	COG4720	Psort location CytoplasmicMembrane, score
FORC4_RS21925	COG1122	ATPase activity
FORC4_RS21940	COG0348	domain, Protein
FORC4_RS21945	COG0437	4 iron, 4 sulfur cluster binding
FORC4_RS21950	COG1247	-acetyltransferase
FORC4_RS21970	COG1067	ATP-dependent peptidase activity
FORC4_RS21980	COG4172	Belongs to the ABC transporter superfamily
FORC4_RS21985	COG1505	serine-type exopeptidase activity
FORC4_RS21990	COG0583	DNA-binding transcription factor activity
FORC4_RS21995	COG1620	l-lactate permease
FORC4_RS22000	COG1304	FMN binding
FORC4_RS22010	COG0668	transmembrane transport
FORC4_RS22045	COG1063	alcohol dehydrogenase
FORC4_RS22050	COG0156	8-amino-7-oxononanoate synthase activity
FORC4_RS22060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_RS22080	COG0745	RESPONSE REGULATOR receiver
FORC4_RS22105	COG0346	lactoylglutathione lyase activity
FORC4_RS22125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC4_RS22205	COG1987	bacterial-type flagellum assembly
FORC4_RS22215	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC4_RS22230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_RS22240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC4_RS22245	COG1516	flagellar protein fliS
FORC4_RS22260	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC4_RS22265	COG1191	sigma factor activity
FORC4_RS22270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC4_RS22275	COG1360	Flagellar Motor Protein
FORC4_RS22320	COG1882	Formate acetyltransferase
FORC4_RS22325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC4_RS22330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC4_RS22340	COG0454	-acetyltransferase
FORC4_RS22350	COG2814	Major facilitator Superfamily
FORC4_RS22370	COG1538	Outer membrane efflux protein
FORC4_RS22390	COG0628	permease
FORC4_RS22395	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC4_RS22405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC4_RS22415	COG4628	conserved protein (DUF2132)
FORC4_RS22420	COG0583	DNA-binding transcription factor activity
FORC4_RS22445	COG1686	Belongs to the peptidase S11 family
FORC4_RS22460	COG1054	Belongs to the UPF0176 family
FORC4_RS22465	COG3397	chitin binding
FORC4_RS22470	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC4_RS22475	COG2095	MarC family integral membrane protein
FORC4_RS22495	COG0489	protein tyrosine kinase activity
FORC4_RS22495	COG3206	protein involved in exopolysaccharide biosynthesis
FORC4_RS22515	COG0583	DNA-binding transcription factor activity
FORC4_RS22525	COG1301	dicarboxylic acid transport
FORC4_RS22530	COG3339	Conserved Protein
FORC4_RS22535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC4_RS22540	COG0700	Nucleoside recognition
FORC4_RS22545	COG3366	ferrous iron transmembrane transporter activity
FORC4_RS22555	COG0366	Alpha amylase catalytic
FORC4_RS22560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC4_RS22565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FORC4_RS22570	COG1640	4-alpha-glucanotransferase
FORC4_RS22575	COG0058	SHG alpha-glucan phosphorylase activity
FORC4_RS22580	COG2909	trisaccharide binding
FORC4_RS22595	COG1999	signal sequence binding
FORC4_RS22605	COG1263	PTS System
FORC4_RS22605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC4_RS22610	COG1162	GTPase activity
FORC4_RS22615	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC4_RS22625	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC4_RS22635	COG0531	amino acid
FORC4_RS22640	COG1982	Orn Lys Arg decarboxylase major
FORC4_RS22660	COG2356	endonuclease I
FORC4_RS22680	COG4580	involved in the transport of maltose and maltodextrins
FORC4_RS22705	COG0739	heme binding
FORC4_RS22715	COG0612	Peptidase, M16
FORC4_RS22720	COG0840	transmembrane signaling receptor activity
FORC4_RS22725	COG1120	ATPase activity
FORC4_RS22730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC4_RS22735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC4_RS22740	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC4_RS22745	COG4772	TonB-dependent receptor
FORC4_RS22765	COG2814	Major facilitator Superfamily
FORC4_RS22770	COG4264	IucA IucC family
FORC4_RS22775	COG0019	diaminopimelate decarboxylase activity
FORC4_RS22780	COG1653	transport
FORC4_RS22805	COG0826	peptidase U32
FORC4_RS22810	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC4_RS22815	COG1129	ABC transporter
FORC4_RS22820	COG1879	ABC-type sugar transport system periplasmic component
FORC4_RS22825	COG1069	ribulokinase activity
FORC4_RS22835	COG2160	L-arabinose isomerase activity
FORC4_RS22860	COG1764	response to oxidative stress
FORC4_RS22865	COG1846	Transcriptional regulator
FORC4_RS22875	COG3634	alkyl hydroperoxide reductase activity
FORC4_RS22920	COG0583	DNA-binding transcription factor activity
FORC4_RS22925	COG1486	melibiose metabolic process
FORC4_RS22940	COG2258	MOSC domain
FORC4_RS22945	COG0513	Belongs to the DEAD box helicase family
FORC4_RS22955	COG2186	Transcriptional regulator
FORC4_RS22965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC4_RS22975	COG0246	Mannitol dehydrogenase
FORC4_RS22980	COG1904	glucuronate isomerase
FORC4_RS22985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC4_RS22990	COG0800	Aldolase
FORC4_RS23010	COG2207	Transcriptional regulator
FORC4_RS23020	COG1132	(ABC) transporter
FORC4_RS23060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC4_RS23085	COG0259	pyridoxamine-phosphate oxidase activity
FORC4_RS23130	COG4166	transmembrane transport
FORC4_RS23145	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC4_RS23150	COG1263	PTS System
FORC4_RS23150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC4_RS23155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC4_RS23160	COG3340	Belongs to the peptidase S51 family
FORC4_RS23180	COG1444	tRNA N-acetyltransferase activity
FORC4_RS23225	COG3451	type IV secretory pathway VirB4
FORC4_RS23230	COG5268	conjugation
FORC4_RS23255	COG2337	Toxic component of a toxin-antitoxin (TA) module
FORC4_RS23260	COG1192	Involved in chromosome partitioning
FORC4_RS23385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC4_RS23490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC4_RS23525	COG3504	Conjugal transfer protein
FORC4_RS23545	COG4962	Type ii secretion system protein e
FORC4_RS23555	COG3451	type IV secretory pathway VirB4
FORC4_RS23560	COG5268	conjugation
FORC4_RS23605	COG0401	homolog of Blt101
FORC4_RS24005	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_RS24150	COG4628	conserved protein (DUF2132)
FORC4_RS24635	COG3335	DDE superfamily endonuclease
FORC4_RS24770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC4_RS24770	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FORC4_RS24990	COG3140	Belongs to the UPF0181 family
FORC4_RS25040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein