locus-tag	class	description
FORC18_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC18_RS00010	COG0592	DNA-directed DNA polymerase activity
FORC18_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC18_RS00020	COG0187	DNA topoisomerase II activity
FORC18_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC18_RS00035	COG3977	Valine--pyruvate aminotransferase
FORC18_RS00040	COG0366	Alpha amylase catalytic
FORC18_RS00055	COG2119	membrane
FORC18_RS00065	COG0425	Belongs to the sulfur carrier protein TusA family
FORC18_RS00080	COG0604	alcohol dehydrogenase
FORC18_RS00085	COG0183	Belongs to the thiolase family
FORC18_RS00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC18_RS00090	COG1024	Enoyl-CoA hydratase
FORC18_RS00095	COG1739	Uncharacterized protein family UPF0029
FORC18_RS00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC18_RS00155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC18_RS00160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC18_RS00170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC18_RS00175	COG2104	thiamine diphosphate biosynthetic process
FORC18_RS00180	COG2022	thiamine diphosphate biosynthetic process
FORC18_RS00190	COG0006	proline dipeptidase activity
FORC18_RS00190	COG0006	proline dipeptidase activity
FORC18_RS00220	COG3220	belongs to the UPF0276 family
FORC18_RS00230	COG0210	DNA helicase
FORC18_RS00235	COG0405	Gamma-glutamyltransferase
FORC18_RS00240	COG1280	lysine exporter protein (LysE YggA)
FORC18_RS00250	COG2962	Rard protein
FORC18_RS00255	COG0514	ATP-dependent DNA helicase (RecQ)
FORC18_RS00265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC18_RS00270	COG0248	Ppx GppA phosphatase
FORC18_RS00275	COG0513	Belongs to the DEAD box helicase family
FORC18_RS00280	COG3118	belongs to the thioredoxin family
FORC18_RS00295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC18_RS00300	COG0633	Ferredoxin
FORC18_RS00350	COG3071	HemY protein
FORC18_RS00355	COG2959	enzyme of heme biosynthesis
FORC18_RS00360	COG1587	Uroporphyrinogen-III synthase
FORC18_RS00365	COG0181	hydroxymethylbilane synthase activity
FORC18_RS00370	COG3072	Adenylate cyclase
FORC18_RS00375	COG1965	Belongs to the frataxin family
FORC18_RS00385	COG0019	diaminopimelate decarboxylase activity
FORC18_RS00390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC18_RS00400	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC18_RS00405	COG1011	Hydrolase
FORC18_RS00410	COG2200	EAL domain
FORC18_RS00410	COG2199	diguanylate cyclase activity
FORC18_RS00410	COG3287	FIST C domain
FORC18_RS00415	COG3148	PFAM DTW domain containing protein
FORC18_RS00430	COG0561	phosphatase activity
FORC18_RS00435	COG2267	carboxylic ester hydrolase activity
FORC18_RS00440	COG1280	lysine exporter protein (LysE YggA)
FORC18_RS00445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC18_RS00450	COG0640	Transcriptional regulator
FORC18_RS00455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC18_RS00510	COG2095	MarC family integral membrane protein
FORC18_RS00520	COG0742	ribosomal rna small subunit methyltransferase
FORC18_RS00525	COG0552	protein localization to endoplasmic reticulum
FORC18_RS00530	COG2884	Cell division ATP-binding protein ftsE
FORC18_RS00535	COG2177	Part of the ABC transporter FtsEX involved in
FORC18_RS00550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC18_RS00555	COG0705	Rhomboid family
FORC18_RS00560	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC18_RS00565	COG3161	chorismate lyase activity
FORC18_RS00570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC18_RS00575	COG2937	Belongs to the GPAT DAPAT family
FORC18_RS00580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC18_RS00585	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC18_RS00590	COG0534	Mate efflux family protein
FORC18_RS00595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC18_RS00610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC18_RS00615	COG4206	TonB-dependent receptor
FORC18_RS00625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC18_RS00680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC18_RS00690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC18_RS00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC18_RS00730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC18_RS00735	COG0250	Participates in transcription elongation, termination and antitermination
FORC18_RS00740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC18_RS00745	COG0081	regulation of translation
FORC18_RS00750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC18_RS00755	COG0222	ribosome binding
FORC18_RS00760	COG0085	RNA polymerase activity
FORC18_RS00765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC18_RS00770	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC18_RS00775	COG2816	NAD+ diphosphatase activity
FORC18_RS00790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC18_RS00795	COG1573	uracil-dna glycosylase
FORC18_RS00800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC18_RS00810	COG1253	flavin adenine dinucleotide binding
FORC18_RS00825	COG0151	Belongs to the GarS family
FORC18_RS00830	COG0138	bifunctional purine biosynthesis protein purh
FORC18_RS00840	COG0789	Transcriptional regulator
FORC18_RS00845	COG3710	Transcriptional regulator
FORC18_RS00860	COG0531	amino acid
FORC18_RS00865	COG1982	Orn Lys Arg decarboxylase major
FORC18_RS00935	COG3706	GGDEF domain
FORC18_RS00940	COG0488	(ABC) transporter
FORC18_RS00945	COG2814	Major facilitator Superfamily
FORC18_RS00950	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC18_RS00955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC18_RS00960	COG2264	protein methyltransferase activity
FORC18_RS00965	COG0439	Biotin carboxylase
FORC18_RS00970	COG0511	ligase activity, forming carbon-carbon bonds
FORC18_RS00975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC18_RS00980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC18_RS00995	COG2814	Major facilitator Superfamily
FORC18_RS01000	COG0784	Response regulator, receiver
FORC18_RS01000	COG2198	Histidine kinase
FORC18_RS01000	COG2205	protein histidine kinase activity
FORC18_RS01020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC18_RS01030	COG3263	regulation of cellular component size
FORC18_RS01040	COG4232	protein-disulfide reductase activity
FORC18_RS01045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC18_RS01050	COG1027	Aspartate ammonia-lyase
FORC18_RS01055	COG3030	protein affecting phage T7 exclusion by the F plasmid
FORC18_RS01060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC18_RS01070	COG2205	protein histidine kinase activity
FORC18_RS01075	COG0745	RESPONSE REGULATOR receiver
FORC18_RS01080	COG3678	ATP-independent chaperone mediated protein folding
FORC18_RS01090	COG0205	6-phosphofructokinase activity
FORC18_RS01095	COG0534	Mate efflux family protein
FORC18_RS01110	COG0459	protein refolding
FORC18_RS01130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC18_RS01140	COG1509	lysine 2,3-aminomutase activity
FORC18_RS01145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC18_RS01155	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC18_RS01160	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC18_RS01165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC18_RS01170	COG1053	succinate dehydrogenase
FORC18_RS01175	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC18_RS01195	COG4942	peptidase
FORC18_RS01200	COG1045	serine acetyltransferase
FORC18_RS01205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC18_RS01210	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC18_RS01215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC18_RS01220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC18_RS01230	COG0840	transmembrane signaling receptor activity
FORC18_RS01235	COG0471	metal ion transport
FORC18_RS01240	COG0688	phosphatidylethanolamine metabolic process
FORC18_RS01245	COG1162	GTPase activity
FORC18_RS01250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC18_RS01320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC18_RS01325	COG0802	atpase or kinase
FORC18_RS01330	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC18_RS01335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC18_RS01340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC18_RS01350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC18_RS01355	COG0330	HflC and HflK could
FORC18_RS01360	COG0330	HflC and HflK could
FORC18_RS01365	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC18_RS01370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC18_RS01375	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC18_RS01380	COG1017	nitric oxide dioxygenase activity
FORC18_RS01380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC18_RS01385	COG1959	2 iron, 2 sulfur cluster binding
FORC18_RS01390	COG0557	exoribonuclease II activity
FORC18_RS01395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC18_RS01400	COG0546	phosphoglycolate phosphatase activity
FORC18_RS01405	COG0180	Tryptophanyl-tRNA synthetase
FORC18_RS01420	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC18_RS01425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC18_RS01435	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_RS01445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC18_RS01450	COG3954	Phosphoribulokinase
FORC18_RS01455	COG3089	Belongs to the UPF0270 family
FORC18_RS01460	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC18_RS01470	COG0488	(ABC) transporter
FORC18_RS01475	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC18_RS01490	COG1047	Peptidyl-prolyl cis-trans
FORC18_RS01495	COG1446	asparaginase
FORC18_RS01500	COG2900	Belongs to the SlyX family
FORC18_RS01510	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC18_RS01515	COG2964	Protein conserved in bacteria
FORC18_RS01520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC18_RS01525	COG2923	Belongs to the DsrF TusC family
FORC18_RS01530	COG2168	tRNA wobble position uridine thiolation
FORC18_RS01540	COG0049	tRNA binding
FORC18_RS01545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC18_RS01550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC18_RS01555	COG2906	2 iron, 2 sulfur cluster binding
FORC18_RS01565	COG0281	malic enzyme
FORC18_RS01575	COG0626	cystathionine gamma-synthase activity
FORC18_RS01580	COG0527	aspartate kinase activity
FORC18_RS01580	COG0460	homoserine dehydrogenase
FORC18_RS01585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC18_RS01595	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC18_RS01600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC18_RS01605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORC18_RS01610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC18_RS01615	COG0137	argininosuccinate synthase activity
FORC18_RS01620	COG0165	Argininosuccinate lyase
FORC18_RS01620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC18_RS01630	COG0678	peroxiredoxin activity
FORC18_RS01630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC18_RS01640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC18_RS01670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC18_RS01675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC18_RS01685	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC18_RS01690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC18_RS01695	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC18_RS01700	COG2965	DNA replication, synthesis of RNA primer
FORC18_RS01710	COG0359	binds to the 23S rRNA
FORC18_RS01725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC18_RS01735	COG0432	Pfam Uncharacterised protein family UPF0047
FORC18_RS01740	COG0166	Belongs to the GPI family
FORC18_RS01750	COG0735	belongs to the Fur family
FORC18_RS01755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC18_RS01775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC18_RS01780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC18_RS01785	COG0175	sulfate reduction
FORC18_RS01860	COG0646	methionine synthase
FORC18_RS01860	COG1410	methionine synthase
FORC18_RS01865	COG0527	aspartate kinase activity
FORC18_RS01875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC18_RS01885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC18_RS01900	COG0629	single-stranded DNA binding
FORC18_RS01905	COG2199	diguanylate cyclase activity
FORC18_RS01905	COG2200	EAL domain
FORC18_RS01930	COG3409	Peptidoglycan-binding domain 1 protein
FORC18_RS01930	COG3267	Type II secretory pathway component ExeA
FORC18_RS01940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC18_RS01945	COG1459	type II secretion system
FORC18_RS01990	COG1077	Cell shape determining protein MreB Mrl
FORC18_RS01995	COG1792	Involved in formation and maintenance of cell shape
FORC18_RS02000	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC18_RS02005	COG0424	maF-like protein
FORC18_RS02015	COG3164	Protein of unknown function
FORC18_RS02020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC18_RS02025	COG0312	modulator of DNA gyrase
FORC18_RS02030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC18_RS02035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC18_RS02045	COG0564	pseudouridine synthase activity
FORC18_RS02050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC18_RS02055	COG3028	Belongs to the UPF0307 family
FORC18_RS02060	COG0312	modulator of DNA gyrase
FORC18_RS02065	COG2239	Acts as a magnesium transporter
FORC18_RS02070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_RS02075	COG1660	Displays ATPase and GTPase activities
FORC18_RS02080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_RS02085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC18_RS02095	COG1137	ATPase activity
FORC18_RS02100	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC18_RS02110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC18_RS02110	COG0517	IMP dehydrogenase activity
FORC18_RS02120	COG1127	ABC transporter
FORC18_RS02125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC18_RS02130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC18_RS02135	COG2854	intermembrane phospholipid transfer
FORC18_RS02145	COG5007	Belongs to the BolA IbaG family
FORC18_RS02150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC18_RS02155	COG0204	Acyl-transferase
FORC18_RS02160	COG0251	oxidation-reduction process
FORC18_RS02165	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC18_RS02170	COG0540	Belongs to the ATCase OTCase family
FORC18_RS02180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FORC18_RS02185	COG2235	arginine
FORC18_RS02210	COG0525	valine-tRNA ligase activity
FORC18_RS02215	COG2927	DNA polymerase III (CHI subunit)
FORC18_RS02220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC18_RS02225	COG0795	lipopolysaccharide-transporting ATPase activity
FORC18_RS02230	COG0795	lipopolysaccharide-transporting ATPase activity
FORC18_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_RS02255	COG0726	polysaccharide deacetylase
FORC18_RS02260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC18_RS02265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC18_RS02270	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC18_RS02275	COG1486	melibiose metabolic process
FORC18_RS02280	COG3394	polysaccharide catabolic process
FORC18_RS02290	COG3437	response regulator, receiver
FORC18_RS02340	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_RS02370	COG0840	transmembrane signaling receptor activity
FORC18_RS02410	COG0741	lytic transglycosylase activity
FORC18_RS02415	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC18_RS02425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC18_RS02435	COG2066	Belongs to the glutaminase family
FORC18_RS02440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC18_RS02445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC18_RS02455	COG1872	DUF167
FORC18_RS02460	COG0762	integral membrane protein
FORC18_RS02465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC18_RS02470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC18_RS02485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC18_RS02490	COG1678	Uncharacterized ACR, COG1678
FORC18_RS02495	COG0189	ligase activity
FORC18_RS02500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC18_RS02505	COG2356	endonuclease I
FORC18_RS02510	COG3091	SprT-like family
FORC18_RS02520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC18_RS02530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC18_RS02535	COG0583	DNA-binding transcription factor activity
FORC18_RS02540	COG4771	TonB-dependent receptor
FORC18_RS02545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC18_RS02550	COG0126	phosphoglycerate kinase activity
FORC18_RS02555	COG0191	fructose-bisphosphate aldolase activity
FORC18_RS02560	COG0668	transmembrane transport
FORC18_RS02565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC18_RS02575	COG0583	DNA-binding transcription factor activity
FORC18_RS02585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC18_RS02590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC18_RS02595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC18_RS02605	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC18_RS02610	COG3079	Belongs to the UPF0149 family
FORC18_RS02615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC18_RS02620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC18_RS02635	COG0354	folic acid binding
FORC18_RS02640	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FORC18_RS02650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC18_RS02655	COG1595	DNA-templated transcription, initiation
FORC18_RS02660	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC18_RS02670	COG3086	response to oxidative stress
FORC18_RS02675	COG0481	GTPase activity
FORC18_RS02685	COG0571	ribonuclease III activity
FORC18_RS02690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC18_RS02695	COG1381	Involved in DNA repair and RecF pathway recombination
FORC18_RS02700	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC18_RS02705	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC18_RS02720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC18_RS02725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC18_RS02730	COG3956	TIGRFAM MazG family protein
FORC18_RS02735	COG0504	CTP synthase activity
FORC18_RS02740	COG0148	phosphopyruvate hydratase activity
FORC18_RS02745	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC18_RS02750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC18_RS02755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC18_RS02760	COG0585	pseudouridine synthase activity
FORC18_RS02765	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC18_RS02770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC18_RS02780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC18_RS02785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC18_RS02790	COG1546	Belongs to the CinA family
FORC18_RS02795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC18_RS02800	COG2137	regulation of response to DNA damage stimulus
FORC18_RS02805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC18_RS02810	COG0527	aspartate kinase activity
FORC18_RS02870	COG3630	sodium ion export across plasma membrane
FORC18_RS02875	COG5016	pyruvate
FORC18_RS02875	COG0511	ligase activity, forming carbon-carbon bonds
FORC18_RS02880	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC18_RS02890	COG1238	metal cluster binding
FORC18_RS02895	COG0612	Peptidase, M16
FORC18_RS02900	COG2918	glutathione biosynthetic process
FORC18_RS02910	COG1854	S-ribosylhomocysteine lyase activity
FORC18_RS02915	COG4536	flavin adenine dinucleotide binding
FORC18_RS02920	COG4137	Cytochrome C assembly protein
FORC18_RS02925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC18_RS02930	COG0228	four-way junction DNA binding
FORC18_RS02935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC18_RS02940	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC18_RS02945	COG0335	large ribosomal subunit rRNA binding
FORC18_RS02950	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC18_RS02955	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC18_RS02960	COG0237	dephospho-CoA kinase activity
FORC18_RS02970	COG1459	type II secretion system
FORC18_RS02975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC18_RS02985	COG0157	Belongs to the NadC ModD family
FORC18_RS02995	COG2186	Transcriptional regulator
FORC18_RS03000	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC18_RS03005	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC18_RS03010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC18_RS03025	COG0288	reversible hydration of carbon dioxide
FORC18_RS03030	COG0659	secondary active sulfate transmembrane transporter activity
FORC18_RS03035	COG1131	(ABC) transporter
FORC18_RS03040	COG0842	Transport permease protein
FORC18_RS03050	COG1560	Kdo2-lipid A biosynthetic process
FORC18_RS03055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC18_RS03060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC18_RS03065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC18_RS03075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC18_RS03085	COG1489	DNA binding
FORC18_RS03090	COG1643	Atp-dependent helicase
FORC18_RS03095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC18_RS03100	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC18_RS03105	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC18_RS03110	COG3112	Uncharacterised protein family (UPF0231)
FORC18_RS03120	COG0004	ammonium transporteR
FORC18_RS03125	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC18_RS03135	COG3842	ATPase activity
FORC18_RS03140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC18_RS03155	COG2971	BadF BadG BcrA BcrD
FORC18_RS03165	COG4608	Belongs to the ABC transporter superfamily
FORC18_RS03170	COG0444	Belongs to the ABC transporter superfamily
FORC18_RS03175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC18_RS03185	COG0747	negative chemotaxis
FORC18_RS03190	COG0784	Response regulator, receiver
FORC18_RS03190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_RS03190	COG2198	Histidine kinase
FORC18_RS03190	COG2205	protein histidine kinase activity
FORC18_RS03200	COG2813	Specifically methylates the guanine in position
FORC18_RS03205	COG0628	permease
FORC18_RS03210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC18_RS03215	COG0316	Belongs to the HesB IscA family
FORC18_RS03225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC18_RS03230	COG0739	heme binding
FORC18_RS03235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC18_RS03250	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC18_RS03255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC18_RS03260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC18_RS03265	COG1534	Rna-binding protein
FORC18_RS03270	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC18_RS03275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC18_RS03280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC18_RS03285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC18_RS03295	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC18_RS03310	COG0779	Required for maturation of 30S ribosomal subunits
FORC18_RS03315	COG0195	Participates in both transcription termination and antitermination
FORC18_RS03320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC18_RS03325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC18_RS03330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC18_RS03335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC18_RS03340	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC18_RS03355	COG0534	Mate efflux family protein
FORC18_RS03360	COG0826	peptidase U32
FORC18_RS03365	COG0826	peptidase U32
FORC18_RS03380	COG3154	lipid carrier protein
FORC18_RS03385	COG3153	acetyltransferase
FORC18_RS03405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC18_RS03415	COG0084	hydrolase, TatD family'
FORC18_RS03420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC18_RS03425	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC18_RS03430	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC18_RS03435	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC18_RS03440	COG0813	purine-nucleoside phosphorylase activity
FORC18_RS03450	COG0560	Phosphoserine phosphatase
FORC18_RS03460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC18_RS03465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC18_RS03470	COG0583	DNA-binding transcription factor activity
FORC18_RS03480	COG1022	Amp-dependent synthetase and ligase
FORC18_RS03485	COG2169	Transcriptional regulator
FORC18_RS03510	COG4964	Belongs to the GSP D family
FORC18_RS03570	COG0583	DNA-binding transcription factor activity
FORC18_RS03575	COG0531	amino acid
FORC18_RS03580	COG2731	YhcH YjgK YiaL family protein
FORC18_RS03585	COG3250	beta-galactosidase activity
FORC18_RS03590	COG1609	Transcriptional regulator
FORC18_RS03595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC18_RS03605	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC18_RS03610	COG2017	converts alpha-aldose to the beta-anomer
FORC18_RS03625	COG2176	DNA-directed DNA polymerase activity
FORC18_RS03630	COG1609	Transcriptional regulator
FORC18_RS03635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC18_RS03655	COG0598	Magnesium transport protein CorA
FORC18_RS03660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC18_RS03665	COG1349	DNA-binding transcription factor activity
FORC18_RS03670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC18_RS03675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC18_RS03680	COG2271	Major facilitator Superfamily
FORC18_RS03685	COG0584	glycerophosphoryl diester phosphodiesterase
FORC18_RS03690	COG2171	N-acyltransferase activity
FORC18_RS03695	COG3141	response to X-ray
FORC18_RS03715	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC18_RS03725	COG1074	ATP-dependent DNA helicase activity
FORC18_RS03730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC18_RS03740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC18_RS03740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC18_RS03750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC18_RS03755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC18_RS03760	COG2166	iron-sulfur cluster assembly
FORC18_RS03765	COG3706	GGDEF domain
FORC18_RS03770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC18_RS03775	COG0693	protein deglycase activity
FORC18_RS03780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC18_RS03805	COG1595	DNA-templated transcription, initiation
FORC18_RS03825	COG3056	Lipoprotein
FORC18_RS03830	COG2813	Specifically methylates the guanine in position
FORC18_RS03835	COG0271	Belongs to the BolA IbaG family
FORC18_RS03845	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC18_RS03850	COG1805	sodium ion transport
FORC18_RS03855	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC18_RS03860	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC18_RS03865	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC18_RS03870	COG2871	sodium ion transport
FORC18_RS03875	COG1477	protein flavinylation
FORC18_RS03890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC18_RS03895	COG0514	ATP-dependent DNA helicase (RecQ)
FORC18_RS03900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC18_RS03915	COG0733	neurotransmitter:sodium symporter activity
FORC18_RS03935	COG0442	prolyl-tRNA aminoacylation
FORC18_RS03940	COG1720	tRNA m6t6A37 methyltransferase activity
FORC18_RS03945	COG0254	rRNA binding
FORC18_RS03955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC18_RS03960	COG1671	Belongs to the UPF0178 family
FORC18_RS03985	COG3098	single-species biofilm formation
FORC18_RS03990	COG0564	pseudouridine synthase activity
FORC18_RS04000	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC18_RS04005	COG0024	Methionine aminopeptidase
FORC18_RS04010	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC18_RS04015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC18_RS04020	COG0528	UMP kinase activity
FORC18_RS04025	COG0233	cytoplasmic translational termination
FORC18_RS04030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC18_RS04035	COG0575	Belongs to the CDS family
FORC18_RS04040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC18_RS04045	COG0750	zinc metalloprotease
FORC18_RS04055	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC18_RS04060	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC18_RS04065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC18_RS04070	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC18_RS04075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC18_RS04080	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC18_RS04085	COG0587	DNA-directed DNA polymerase activity
FORC18_RS04090	COG0825	malonyl-CoA metabolic process
FORC18_RS04095	COG0037	tRNA processing
FORC18_RS04105	COG0347	Belongs to the P(II) protein family
FORC18_RS04110	COG3021	interspecies interaction between organisms
FORC18_RS04120	COG1388	LysM domain
FORC18_RS04120	COG0741	lytic transglycosylase activity
FORC18_RS04125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC18_RS04130	COG2226	methyltransferase
FORC18_RS04135	COG0328	RNA-DNA hybrid ribonuclease activity
FORC18_RS04140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC18_RS04170	COG1960	acyl-CoA dehydrogenase activity
FORC18_RS04175	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC18_RS04180	COG0121	glutamine amidotransferase
FORC18_RS04185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC18_RS04190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC18_RS04195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC18_RS04200	COG2233	PERMEase
FORC18_RS04220	COG1393	Belongs to the ArsC family
FORC18_RS04225	COG4783	chaperone-mediated protein folding
FORC18_RS04240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC18_RS04245	COG2716	regulation of RNA biosynthetic process
FORC18_RS04250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC18_RS04255	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FORC18_RS04270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC18_RS04275	COG1393	Belongs to the ArsC family
FORC18_RS04305	COG2837	iron assimilation
FORC18_RS04310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_RS04320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_RS04325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_RS04330	COG1334	flagellar protein FlaG
FORC18_RS04335	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC18_RS04345	COG1516	flagellar protein fliS
FORC18_RS04365	COG1677	Flagellar hook-basal body complex protein FliE
FORC18_RS04375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC18_RS04425	COG1987	bacterial-type flagellum assembly
FORC18_RS04430	COG1684	flagellar biosynthetic protein fliR
FORC18_RS04465	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC18_RS04470	COG0643	Histidine kinase
FORC18_RS04470	COG0784	Response regulator, receiver
FORC18_RS04470	COG2198	Histidine kinase
FORC18_RS04475	COG2201	protein-glutamate methylesterase activity
FORC18_RS04480	COG1192	Involved in chromosome partitioning
FORC18_RS04490	COG0835	chemotaxis
FORC18_RS04500	COG4133	protoheme IX ABC transporter activity
FORC18_RS04505	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC18_RS04510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC18_RS04515	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC18_RS04520	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC18_RS04525	COG1138	Cytochrome C-type biogenesis protein
FORC18_RS04530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC18_RS04545	COG2853	Lipoprotein
FORC18_RS04550	COG2067	long-chain fatty acid transport protein
FORC18_RS04555	COG2067	long-chain fatty acid transport protein
FORC18_RS04575	COG0183	Belongs to the thiolase family
FORC18_RS04580	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC18_RS04580	COG1024	Enoyl-CoA hydratase
FORC18_RS04595	COG2062	phosphohistidine phosphatase, SixA
FORC18_RS04600	COG2840	Smr protein MutS2
FORC18_RS04605	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC18_RS04610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC18_RS04615	COG2860	membrane
FORC18_RS04620	COG3101	peptidyl-lysine hydroxylation
FORC18_RS04630	COG0431	NADPH-dependent FMN reductase
FORC18_RS04635	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC18_RS04635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC18_RS04640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC18_RS04645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC18_RS04650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC18_RS04660	COG0101	tRNA pseudouridine synthase activity
FORC18_RS04670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC18_RS04675	COG0285	dihydrofolate synthase activity
FORC18_RS04680	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC18_RS04685	COG1286	toxin biosynthetic process
FORC18_RS04690	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC18_RS04695	COG0583	DNA-binding transcription factor activity
FORC18_RS04700	COG0745	RESPONSE REGULATOR receiver
FORC18_RS04705	COG2832	Protein of unknown function (DUF454)
FORC18_RS04710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC18_RS04720	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC18_RS04725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC18_RS04730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC18_RS04735	COG0814	amino acid
FORC18_RS04740	COG0251	oxidation-reduction process
FORC18_RS04745	COG3681	Belongs to the UPF0597 family
FORC18_RS04760	COG2261	transglycosylase associated protein
FORC18_RS04765	COG2983	Belongs to the UPF0260 family
FORC18_RS04770	COG0668	transmembrane transport
FORC18_RS04775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC18_RS04780	COG0346	lactoylglutathione lyase activity
FORC18_RS04790	COG1785	Belongs to the alkaline phosphatase family
FORC18_RS04805	COG2226	methyltransferase
FORC18_RS04820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC18_RS04825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC18_RS04835	COG3139	Protein of unknown function (DUF1315)
FORC18_RS04840	COG0252	asparaginase activity
FORC18_RS04845	COG0616	signal peptide processing
FORC18_RS04850	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC18_RS04850	COG1902	pentaerythritol trinitrate reductase activity
FORC18_RS04855	COG0778	Nitroreductase
FORC18_RS04860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC18_RS04875	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC18_RS04885	COG3083	sulfuric ester hydrolase activity
FORC18_RS04890	COG3082	Protein of unknown function (DUF1414)
FORC18_RS04895	COG3081	Nucleoid-associated protein
FORC18_RS04910	COG1757	Na H antiporter
FORC18_RS04915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC18_RS04920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC18_RS04925	COG2095	MarC family integral membrane protein
FORC18_RS04930	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_RS04930	COG1454	alcohol dehydrogenase
FORC18_RS04950	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC18_RS04960	COG2056	Na+-H+ antiporter family
FORC18_RS04965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC18_RS04970	COG2885	chlorophyll binding
FORC18_RS04980	COG0346	lactoylglutathione lyase activity
FORC18_RS04985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC18_RS04990	COG4660	Part of a membrane complex involved in electron transport
FORC18_RS04995	COG4659	FMN binding
FORC18_RS05000	COG4658	electron transport chain
FORC18_RS05005	COG4656	Part of a membrane complex involved in electron transport
FORC18_RS05010	COG2878	Part of a membrane complex involved in electron transport
FORC18_RS05015	COG4657	Part of a membrane complex involved in electron transport
FORC18_RS05025	COG0556	nucleotide-excision repair
FORC18_RS05030	COG2204	response regulator
FORC18_RS05035	COG2198	Histidine kinase
FORC18_RS05040	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC18_RS05045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC18_RS05050	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC18_RS05055	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC18_RS05060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC18_RS05065	COG0314	molybdopterin synthase activity
FORC18_RS05075	COG0601	transmembrane transport
FORC18_RS05080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC18_RS05085	COG0444	Belongs to the ABC transporter superfamily
FORC18_RS05095	COG0435	Glutathione S-transferase
FORC18_RS05105	COG3174	membrane
FORC18_RS05110	COG0280	phosphate acetyltransferase
FORC18_RS05110	COG0857	belongs to the CobB CobQ family
FORC18_RS05115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC18_RS05120	COG3092	negative regulation of chromosome organization
FORC18_RS05130	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC18_RS05135	COG1122	ATPase activity
FORC18_RS05140	COG0366	Alpha amylase catalytic
FORC18_RS05150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC18_RS05155	COG0653	protein targeting
FORC18_RS05160	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC18_RS05165	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC18_RS05170	COG2186	Transcriptional regulator
FORC18_RS05180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC18_RS05180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC18_RS05185	COG0489	protein tyrosine kinase activity
FORC18_RS05190	COG0572	uridine kinase
FORC18_RS05200	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC18_RS05205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC18_RS05210	COG0659	secondary active sulfate transmembrane transporter activity
FORC18_RS05215	COG1530	ribonuclease E activity
FORC18_RS05225	COG0564	pseudouridine synthase activity
FORC18_RS05230	COG0424	maF-like protein
FORC18_RS05235	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC18_RS05245	COG0416	fatty acid biosynthetic process
FORC18_RS05250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC18_RS05280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC18_RS05285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC18_RS05295	COG0084	hydrolase, TatD family'
FORC18_RS05300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC18_RS05300	COG1263	PTS System
FORC18_RS05310	COG0733	neurotransmitter:sodium symporter activity
FORC18_RS05320	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC18_RS05325	COG0469	pyruvate kinase activity
FORC18_RS05330	COG1940	carbohydrate kinase activity
FORC18_RS05335	COG0835	chemotaxis
FORC18_RS05335	COG0784	Response regulator, receiver
FORC18_RS05340	COG0587	DNA-directed DNA polymerase activity
FORC18_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_RS05360	COG0616	signal peptide processing
FORC18_RS05365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC18_RS05370	COG0539	negative regulation of cytoplasmic translation
FORC18_RS05380	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC18_RS05385	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC18_RS05390	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC18_RS05395	COG4166	transmembrane transport
FORC18_RS05410	COG0463	Glycosyl transferase, family 2
FORC18_RS05420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC18_RS05430	COG3008	intermembrane lipid transfer
FORC18_RS05430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC18_RS05435	COG2995	paraquat-inducible protein a
FORC18_RS05440	COG3258	Cytochrome c
FORC18_RS05445	COG2863	cytochrome
FORC18_RS05485	COG4232	protein-disulfide reductase activity
FORC18_RS05490	COG3118	belongs to the thioredoxin family
FORC18_RS05505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC18_RS05520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_RS05530	COG1136	(ABC) transporter
FORC18_RS05530	COG0577	efflux transmembrane transporter activity
FORC18_RS05535	COG0577	efflux transmembrane transporter activity
FORC18_RS05535	COG1136	(ABC) transporter
FORC18_RS05540	COG1136	(ABC) transporter
FORC18_RS05540	COG0577	efflux transmembrane transporter activity
FORC18_RS05545	COG1335	isochorismatase
FORC18_RS05600	COG5002	protein histidine kinase activity
FORC18_RS05600	COG3850	Histidine kinase
FORC18_RS05605	COG0745	RESPONSE REGULATOR receiver
FORC18_RS05610	COG0840	transmembrane signaling receptor activity
FORC18_RS05615	COG1032	radical SAM domain protein
FORC18_RS05620	COG2203	Gaf domain
FORC18_RS05620	COG4251	negative regulation of phosphorylation
FORC18_RS05620	COG5001	Diguanylate cyclase
FORC18_RS05620	COG3706	GGDEF domain
FORC18_RS05640	COG0583	DNA-binding transcription factor activity
FORC18_RS05645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC18_RS05655	COG2350	Protein conserved in bacteria
FORC18_RS05665	COG2917	probably involved in intracellular septation
FORC18_RS05685	COG1301	dicarboxylic acid transport
FORC18_RS05690	COG0318	PFAM AMP-dependent synthetase and ligase
FORC18_RS05695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC18_RS05700	COG0159	tryptophan synthase activity
FORC18_RS05705	COG0133	tryptophan synthase activity
FORC18_RS05710	COG0134	indole-3-glycerol-phosphate synthase activity
FORC18_RS05710	COG0135	phosphoribosylanthranilate isomerase activity
FORC18_RS05715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC18_RS05720	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC18_RS05725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC18_RS05735	COG0613	PHP domain protein
FORC18_RS05740	COG0009	L-threonylcarbamoyladenylate synthase
FORC18_RS05750	COG1187	pseudouridine synthase activity
FORC18_RS05755	COG3099	Belongs to the UPF0263 family
FORC18_RS05760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC18_RS05770	COG0417	DNA replication proofreading
FORC18_RS05775	COG2197	response regulator
FORC18_RS05780	COG0322	excinuclease ABC activity
FORC18_RS05825	COG0019	diaminopimelate decarboxylase activity
FORC18_RS05850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC18_RS05855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC18_RS05865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC18_RS05885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC18_RS05895	COG0437	4 iron, 4 sulfur cluster binding
FORC18_RS05900	COG3301	Polysulphide reductase, NrfD
FORC18_RS05905	COG1138	Cytochrome C-type biogenesis protein
FORC18_RS05915	COG4235	cytochrome complex assembly
FORC18_RS05915	COG3088	subunit of a heme lyase
FORC18_RS05925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC18_RS05950	COG2989	Protein conserved in bacteria
FORC18_RS05955	COG3108	Peptidase M15
FORC18_RS05960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC18_RS05975	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC18_RS06000	COG1846	Transcriptional regulator
FORC18_RS06005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC18_RS06030	COG1448	Aminotransferase
FORC18_RS06045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC18_RS06055	COG0017	Asparaginyl-tRNA synthetase
FORC18_RS06065	COG0720	synthase
FORC18_RS06075	COG2200	EAL domain
FORC18_RS06080	COG1760	l-serine dehydratase
FORC18_RS06085	COG0814	amino acid
FORC18_RS06090	COG0494	nUDIX hydrolase
FORC18_RS06100	COG0784	Response regulator, receiver
FORC18_RS06100	COG2205	protein histidine kinase activity
FORC18_RS06105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC18_RS06120	COG3106	COG3106 Predicted ATPase
FORC18_RS06125	COG3768	UPF0283 membrane protein
FORC18_RS06135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC18_RS06375	COG0494	nUDIX hydrolase
FORC18_RS06430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC18_RS06450	COG0494	nUDIX hydrolase
FORC18_RS06465	COG1683	Conserved Protein
FORC18_RS06690	COG0456	acetyltransferase
FORC18_RS06710	COG0494	nUDIX hydrolase
FORC18_RS07030	COG1444	tRNA N-acetyltransferase activity
FORC18_RS07065	COG1683	Conserved Protein
FORC18_RS07190	COG1757	Na H antiporter
FORC18_RS07195	COG0174	glutamine synthetase
FORC18_RS07200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FORC18_RS07205	COG1917	Cupin 2, conserved barrel domain protein
FORC18_RS07205	COG1396	sequence-specific DNA binding
FORC18_RS07210	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_RS07215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC18_RS07225	COG2957	Belongs to the agmatine deiminase family
FORC18_RS07230	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_RS07235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC18_RS07240	COG1227	inorganic diphosphatase activity
FORC18_RS07245	COG2200	EAL domain
FORC18_RS07245	COG2771	luxR family
FORC18_RS07260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC18_RS07265	COG2207	Transcriptional regulator
FORC18_RS07275	COG1846	Transcriptional regulator
FORC18_RS07280	COG2315	Protein conserved in bacteria
FORC18_RS07300	COG0110	maltose O-acetyltransferase activity
FORC18_RS07330	COG3063	Type IV pilus biogenesis stability protein PilW
FORC18_RS07335	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC18_RS07345	COG0531	amino acid
FORC18_RS07350	COG1560	Kdo2-lipid A biosynthetic process
FORC18_RS07355	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC18_RS07360	COG1280	lysine exporter protein (LysE YggA)
FORC18_RS07370	COG1115	amino acid carrier protein
FORC18_RS07390	COG1368	sulfuric ester hydrolase activity
FORC18_RS07395	COG0642	Histidine kinase
FORC18_RS07400	COG0745	RESPONSE REGULATOR receiver
FORC18_RS07410	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_RS07430	COG2113	Glycine betaine
FORC18_RS07435	COG4176	ABC-type proline glycine betaine transport system permease component
FORC18_RS07455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC18_RS07460	COG0456	acetyltransferase
FORC18_RS07465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC18_RS07470	COG0662	Cupin 2, conserved barrel domain protein
FORC18_RS07475	COG0527	aspartate kinase activity
FORC18_RS07480	COG1858	cytochrome C peroxidase
FORC18_RS07495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_RS07510	COG3290	protein histidine kinase activity
FORC18_RS07515	COG4565	transcriptional regulatory protein
FORC18_RS07520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC18_RS07525	COG0363	glucosamine-6-phosphate deaminase activity
FORC18_RS07530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC18_RS07550	COG3284	Transcriptional regulator
FORC18_RS07555	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_RS07625	COG4669	(LipO)protein
FORC18_RS07645	COG3177	Filamentation induced by cAMP protein fic
FORC18_RS07675	COG1073	alpha beta
FORC18_RS07680	COG1073	alpha beta
FORC18_RS07690	COG4792	protein secretion
FORC18_RS07695	COG4791	protein targeting
FORC18_RS07700	COG4794	Type iii secretion
FORC18_RS07705	COG4790	Type iii secretion
FORC18_RS07775	COG0457	Tetratricopeptide repeat
FORC18_RS07795	COG0730	response to heat
FORC18_RS07825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC18_RS07830	COG0372	Belongs to the citrate synthase family
FORC18_RS07840	COG2828	Protein conserved in bacteria
FORC18_RS07865	COG0561	phosphatase activity
FORC18_RS07870	COG0602	queuosine metabolic process
FORC18_RS07875	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC18_RS07880	COG3706	GGDEF domain
FORC18_RS07920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC18_RS07925	COG0840	transmembrane signaling receptor activity
FORC18_RS07930	COG1254	Belongs to the acylphosphatase family
FORC18_RS07935	COG2920	part of a sulfur-relay system
FORC18_RS07945	COG0670	Belongs to the BI1 family
FORC18_RS07950	COG1126	abc transporter atp-binding protein
FORC18_RS07955	COG0765	amino acid transport
FORC18_RS07960	COG4597	amino acid ABC transporter
FORC18_RS07965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_RS07975	COG1666	GTP binding
FORC18_RS07980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC18_RS08000	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FORC18_RS08000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC18_RS08010	COG3008	intermembrane lipid transfer
FORC18_RS08015	COG2995	paraquat-inducible protein a
FORC18_RS08020	COG1132	(ABC) transporter
FORC18_RS08025	COG1956	GAF domain-containing protein
FORC18_RS08030	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FORC18_RS08045	COG0308	aminopeptidase N
FORC18_RS08055	COG2902	Dehydrogenase
FORC18_RS08060	COG0167	dihydroorotate dehydrogenase activity
FORC18_RS08070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC18_RS08070	COG0116	Belongs to the methyltransferase superfamily
FORC18_RS08080	COG0488	(ABC) transporter
FORC18_RS08095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC18_RS08100	COG1067	ATP-dependent peptidase activity
FORC18_RS08105	COG3120	sequence-specific DNA binding
FORC18_RS08230	COG0784	Response regulator, receiver
FORC18_RS08230	COG2205	protein histidine kinase activity
FORC18_RS08245	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC18_RS08260	COG2010	Cytochrome c
FORC18_RS08270	COG2217	Heavy metal translocating P-type atpase
FORC18_RS08285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC18_RS08290	COG0589	response to stress
FORC18_RS08300	COG0037	tRNA processing
FORC18_RS08320	COG3842	ATPase activity
FORC18_RS08330	COG1177	transmembrane transport
FORC18_RS08340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC18_RS08345	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC18_RS08355	COG0004	ammonium transporteR
FORC18_RS08400	COG0437	4 iron, 4 sulfur cluster binding
FORC18_RS08405	COG3383	formate dehydrogenase (NAD+) activity
FORC18_RS08405	COG0243	molybdopterin cofactor binding
FORC18_RS08415	COG3381	protein complex oligomerization
FORC18_RS08435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC18_RS08440	COG0488	(ABC) transporter
FORC18_RS08445	COG4191	Histidine kinase
FORC18_RS08450	COG2204	response regulator
FORC18_RS08465	COG3842	ATPase activity
FORC18_RS08470	COG0746	molybdenum cofactor guanylyltransferase activity
FORC18_RS08475	COG0303	'Molybdopterin
FORC18_RS08485	COG1940	carbohydrate kinase activity
FORC18_RS08490	COG3148	PFAM DTW domain containing protein
FORC18_RS08525	COG0840	transmembrane signaling receptor activity
FORC18_RS08530	COG0791	NLP P60 protein
FORC18_RS08540	COG3706	GGDEF domain
FORC18_RS08545	COG2201	protein-glutamate methylesterase activity
FORC18_RS08550	COG3001	Fructosamine kinase
FORC18_RS08560	COG0307	riboflavin synthase, alpha
FORC18_RS08565	COG0534	Mate efflux family protein
FORC18_RS08575	COG1793	dna ligase
FORC18_RS08605	COG2204	response regulator
FORC18_RS08615	COG0438	transferase activity, transferring glycosyl groups
FORC18_RS08645	COG0438	transferase activity, transferring glycosyl groups
FORC18_RS08650	COG1215	transferase activity, transferring glycosyl groups
FORC18_RS08655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC18_RS08665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC18_RS08680	COG1643	Atp-dependent helicase
FORC18_RS08685	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC18_RS08690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC18_RS08690	COG2221	Nitrite and sulphite reductase 4Fe-4S
FORC18_RS08700	COG3302	dmso reductase anchor subunit
FORC18_RS08705	COG0437	4 iron, 4 sulfur cluster binding
FORC18_RS08710	COG0243	molybdopterin cofactor binding
FORC18_RS08740	COG3706	GGDEF domain
FORC18_RS08750	COG0443	Heat shock 70 kDa protein
FORC18_RS08755	COG0443	Heat shock 70 kDa protein
FORC18_RS08780	COG1132	(ABC) transporter
FORC18_RS08785	COG1132	(ABC) transporter
FORC18_RS08805	COG0814	amino acid
FORC18_RS08815	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC18_RS08885	COG1522	sequence-specific DNA binding
FORC18_RS08920	COG0515	serine threonine protein kinase
FORC18_RS08945	COG3501	Rhs element vgr protein
FORC18_RS08960	COG2204	response regulator
FORC18_RS08985	COG0739	heme binding
FORC18_RS08990	COG0861	Integral membrane protein TerC family
FORC18_RS09000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC18_RS09005	COG1328	CTP reductase activity
FORC18_RS09010	COG1280	lysine exporter protein (LysE YggA)
FORC18_RS09020	COG3300	MHYT domain
FORC18_RS09020	COG5001	Diguanylate cyclase
FORC18_RS09030	COG4191	Histidine kinase
FORC18_RS09030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_RS09035	COG0471	metal ion transport
FORC18_RS09070	COG0583	DNA-binding transcription factor activity
FORC18_RS09075	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC18_RS09135	COG0625	glutathione transferase activity
FORC18_RS09145	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC18_RS09160	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC18_RS09170	COG0601	transmembrane transport
FORC18_RS09175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC18_RS09180	COG0444	Belongs to the ABC transporter superfamily
FORC18_RS09195	COG3291	Pkd domain containing protein
FORC18_RS09210	COG1177	transmembrane transport
FORC18_RS09215	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC18_RS09220	COG3842	ATPase activity
FORC18_RS09225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC18_RS09230	COG2423	ornithine cyclodeaminase activity
FORC18_RS09245	COG3938	Belongs to the proline racemase family
FORC18_RS09275	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC18_RS09280	COG1451	nucleotide metabolic process
FORC18_RS09285	COG3475	LICD family
FORC18_RS09290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC18_RS09295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC18_RS09315	COG0583	DNA-binding transcription factor activity
FORC18_RS09335	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC18_RS09340	COG4139	cobalamin transport
FORC18_RS09345	COG2988	succinylglutamate desuccinylase activity
FORC18_RS09365	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC18_RS09370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC18_RS09375	COG0702	epimerase
FORC18_RS09380	COG1823	symporter activity
FORC18_RS09385	COG2925	Exonuclease
FORC18_RS09390	COG1380	Effector of murein hydrolase LrgA
FORC18_RS09395	COG1346	cytolysis
FORC18_RS09400	COG0295	cytidine deaminase activity
FORC18_RS09405	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC18_RS09410	COG0500	methyltransferase
FORC18_RS09420	COG0776	regulation of translation
FORC18_RS09430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC18_RS09430	COG0072	phenylalanine-tRNA ligase activity
FORC18_RS09435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC18_RS09440	COG3706	GGDEF domain
FORC18_RS09470	COG0393	Putative heavy-metal-binding
FORC18_RS09480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC18_RS09490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC18_RS09505	COG2188	Transcriptional regulator
FORC18_RS09510	COG1228	amidohydrolase
FORC18_RS09515	COG0010	Belongs to the arginase family
FORC18_RS09520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC18_RS09525	COG2986	histidine ammonia-lyase
FORC18_RS09540	COG0277	FAD linked oxidase domain protein
FORC18_RS09540	COG0247	lactate metabolic process
FORC18_RS09575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC18_RS09590	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC18_RS09595	COG1643	Atp-dependent helicase
FORC18_RS09600	COG0281	malic enzyme
FORC18_RS09605	COG2949	membrane
FORC18_RS09610	COG0471	metal ion transport
FORC18_RS09625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC18_RS09635	COG0492	ferredoxin-NADP+ reductase activity
FORC18_RS09640	COG4988	ABC transporter
FORC18_RS09645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC18_RS09650	COG3048	D-serine ammonia-lyase activity
FORC18_RS09655	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC18_RS09665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_RS09665	COG4191	Histidine kinase
FORC18_RS09680	COG3070	regulator of competence-specific genes
FORC18_RS09695	COG2431	L-lysine efflux transmembrane transporter activity
FORC18_RS09705	COG0076	glutamate decarboxylase activity
FORC18_RS09710	COG1737	Transcriptional regulator
FORC18_RS09720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC18_RS09725	COG3273	potassium ion transport
FORC18_RS09725	COG2985	domain, Protein
FORC18_RS09740	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC18_RS09755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC18_RS09770	COG4181	ATPase activity
FORC18_RS09775	COG0534	Mate efflux family protein
FORC18_RS09780	COG0702	epimerase
FORC18_RS09785	COG3005	denitrification pathway
FORC18_RS09815	COG2814	Major facilitator Superfamily
FORC18_RS09820	COG1187	pseudouridine synthase activity
FORC18_RS09825	COG1061	Type III restriction enzyme res subunit
FORC18_RS09845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC18_RS09870	COG3313	Fe-S protein
FORC18_RS09895	COG0493	'glutamate synthase
FORC18_RS09905	COG0398	Pfam SNARE associated Golgi protein
FORC18_RS09910	COG4134	Bacterial extracellular solute-binding protein
FORC18_RS09915	COG4135	transport system, permease component
FORC18_RS09920	COG4136	ATPase activity
FORC18_RS09925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC18_RS09935	COG3604	Transcriptional regulator
FORC18_RS09940	COG1151	hydroxylamine reductase activity
FORC18_RS09945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC18_RS09955	COG0564	pseudouridine synthase activity
FORC18_RS09965	COG0733	neurotransmitter:sodium symporter activity
FORC18_RS09975	COG0626	cystathionine gamma-synthase activity
FORC18_RS09980	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC18_RS09985	COG5380	lipid catabolic process
FORC18_RS09990	COG2818	Glycosylase
FORC18_RS10005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_RS10010	COG1983	PspC domain protein
FORC18_RS10020	COG1842	Phage shock protein A
FORC18_RS10025	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC18_RS10040	COG4171	peptide transport system, permease
FORC18_RS10050	COG4172	Belongs to the ABC transporter superfamily
FORC18_RS10060	COG1227	inorganic diphosphatase activity
FORC18_RS10075	COG0243	molybdopterin cofactor binding
FORC18_RS10080	COG3005	denitrification pathway
FORC18_RS10085	COG4459	periplasmic nitrate reductase
FORC18_RS10090	COG0390	transport system, permease component
FORC18_RS10095	COG2116	formate transmembrane transporter activity
FORC18_RS10120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC18_RS10125	COG1435	thymidine kinase activity
FORC18_RS10130	COG0215	cysteine-tRNA ligase activity
FORC18_RS10135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC18_RS10140	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC18_RS10145	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC18_RS10150	COG3012	SEC-C Motif Domain Protein
FORC18_RS10155	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC18_RS10155	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC18_RS10160	COG0107	imidazoleglycerol-phosphate synthase activity
FORC18_RS10165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC18_RS10170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC18_RS10175	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC18_RS10175	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC18_RS10180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC18_RS10185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORC18_RS10190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC18_RS10205	COG1757	Na H antiporter
FORC18_RS10215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC18_RS10225	COG0482	sulfurtransferase activity
FORC18_RS10230	COG2915	High frequency lysogenization protein hflD homolog
FORC18_RS10235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC18_RS10255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC18_RS10270	COG0300	oxidoreductase activity
FORC18_RS10280	COG0501	Belongs to the peptidase M48B family
FORC18_RS10285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC18_RS10295	COG0156	8-amino-7-oxononanoate synthase activity
FORC18_RS10300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC18_RS10305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC18_RS10310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC18_RS10325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC18_RS10330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC18_RS10335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC18_RS10340	COG1674	ftsk spoiiie
FORC18_RS10350	COG0686	Belongs to the AlaDH PNT family
FORC18_RS10360	COG0583	DNA-binding transcription factor activity
FORC18_RS10375	COG3568	Endonuclease Exonuclease Phosphatase
FORC18_RS10400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC18_RS10405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_RS10410	COG0840	transmembrane signaling receptor activity
FORC18_RS10465	COG0784	Response regulator, receiver
FORC18_RS10465	COG5002	protein histidine kinase activity
FORC18_RS10475	COG0754	glutathionylspermidine amidase activity
FORC18_RS10485	COG3766	membrane
FORC18_RS10495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC18_RS10500	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC18_RS10505	COG2885	chlorophyll binding
FORC18_RS10510	COG0823	Involved in the tonB-independent uptake of proteins
FORC18_RS10525	COG0811	peptide transport
FORC18_RS10530	COG0824	Thioesterase
FORC18_RS10540	COG4890	Cyd operon protein YbgT
FORC18_RS10545	COG1294	oxidase, subunit
FORC18_RS10550	COG1271	oxidase subunit
FORC18_RS10555	COG2255	four-way junction helicase activity
FORC18_RS10560	COG0632	four-way junction helicase activity
FORC18_RS10565	COG0840	transmembrane signaling receptor activity
FORC18_RS10570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC18_RS10575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC18_RS10580	COG1801	Protein of unknown function DUF72
FORC18_RS10585	COG4106	trans-aconitate 2-methyltransferase activity
FORC18_RS10590	COG0500	methyltransferase
FORC18_RS10595	COG0189	ligase activity
FORC18_RS10595	COG4067	protein conserved in archaea
FORC18_RS10610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC18_RS10615	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC18_RS10620	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC18_RS10625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC18_RS10630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC18_RS10635	COG0745	RESPONSE REGULATOR receiver
FORC18_RS10640	COG3381	protein complex oligomerization
FORC18_RS10645	COG1609	Transcriptional regulator
FORC18_RS10650	COG3070	regulator of competence-specific genes
FORC18_RS10670	COG0297	glycogen (starch) synthase activity
FORC18_RS10675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC18_RS10680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC18_RS10690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC18_RS10700	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC18_RS10705	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC18_RS10710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC18_RS10720	COG0542	response to heat
FORC18_RS10725	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC18_RS10730	COG1278	Cold shock
FORC18_RS10740	COG1187	pseudouridine synthase activity
FORC18_RS10745	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC18_RS10755	COG1199	ATP-dependent helicase activity
FORC18_RS10760	COG0730	response to heat
FORC18_RS10765	COG3923	Primosomal replication protein n
FORC18_RS10775	COG0708	Exodeoxyribonuclease III
FORC18_RS10815	COG1882	Formate acetyltransferase
FORC18_RS10825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC18_RS10835	COG3013	Belongs to the UPF0304 family
FORC18_RS10840	COG2766	serine protein kinase
FORC18_RS10845	COG2718	Belongs to the UPF0229 family
FORC18_RS10850	COG2719	SpoVR family
FORC18_RS10855	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC18_RS10865	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC18_RS10870	COG1132	(ABC) transporter
FORC18_RS10885	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC18_RS10890	COG1136	(ABC) transporter
FORC18_RS10895	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC18_RS10905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC18_RS10920	COG1252	NADH dehydrogenase
FORC18_RS10925	COG3150	esterase
FORC18_RS10950	COG0537	adenosine 5'-monophosphoramidase activity
FORC18_RS10975	COG0516	GMP reductase activity
FORC18_RS10975	COG0517	IMP dehydrogenase activity
FORC18_RS10980	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC18_RS10985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC18_RS10990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC18_RS11000	COG2199	diguanylate cyclase activity
FORC18_RS11015	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC18_RS11020	COG1946	Acyl-CoA thioesterase
FORC18_RS11030	COG1522	sequence-specific DNA binding
FORC18_RS11055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC18_RS11105	COG0477	Major facilitator Superfamily
FORC18_RS11110	COG2855	membrane
FORC18_RS11130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC18_RS11135	COG0596	Alpha beta hydrolase
FORC18_RS11140	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC18_RS11145	COG1169	isochorismate synthase
FORC18_RS11150	COG0436	Aminotransferase
FORC18_RS11155	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC18_RS11160	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC18_RS11175	COG1555	photosystem II stabilization
FORC18_RS11180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC18_RS11185	COG0776	regulation of translation
FORC18_RS11190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC18_RS11195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC18_RS11205	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC18_RS11220	COG2204	response regulator
FORC18_RS11230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC18_RS11235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC18_RS11240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC18_RS11245	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FORC18_RS11260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC18_RS11265	COG0569	domain protein
FORC18_RS11270	COG0513	Belongs to the DEAD box helicase family
FORC18_RS11275	COG1253	flavin adenine dinucleotide binding
FORC18_RS11310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC18_RS11315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC18_RS11330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC18_RS11335	COG1216	Glycosyl transferase, family 2
FORC18_RS11340	COG2986	histidine ammonia-lyase
FORC18_RS11365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC18_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_RS11395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC18_RS11400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC18_RS11405	COG0583	DNA-binding transcription factor activity
FORC18_RS11410	COG2951	lytic endotransglycosylase activity
FORC18_RS11415	COG3100	YcgL domain-containing protein
FORC18_RS11420	COG0850	regulation of cytokinetic process
FORC18_RS11425	COG2894	cell division
FORC18_RS11430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC18_RS11435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC18_RS11440	COG0318	PFAM AMP-dependent synthetase and ligase
FORC18_RS11445	COG2267	carboxylic ester hydrolase activity
FORC18_RS11460	COG1214	PFAM Peptidase M22, glycoprotease
FORC18_RS11465	COG1199	ATP-dependent helicase activity
FORC18_RS11470	COG0788	formyltetrahydrofolate deformylase activity
FORC18_RS11475	COG3102	Protein conserved in bacteria
FORC18_RS11480	COG0018	arginyl-trna synthetase
FORC18_RS11500	COG1918	ferrous iron import across plasma membrane
FORC18_RS11505	COG4977	sequence-specific DNA binding
FORC18_RS11510	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC18_RS11515	COG1121	(ABC) transporter
FORC18_RS11520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC18_RS11530	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC18_RS11535	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC18_RS11540	COG0567	Dehydrogenase, E1 component
FORC18_RS11545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC18_RS11550	COG1053	succinate dehydrogenase
FORC18_RS11555	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC18_RS11570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC18_RS11580	COG0033	Phosphoglucomutase
FORC18_RS11585	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC18_RS11590	COG0596	Alpha beta hydrolase
FORC18_RS11600	COG0716	FMN binding
FORC18_RS11610	COG0735	belongs to the Fur family
FORC18_RS11615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC18_RS11620	COG1263	PTS System
FORC18_RS11620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC18_RS11625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC18_RS11630	COG1940	carbohydrate kinase activity
FORC18_RS11630	COG1846	Transcriptional regulator
FORC18_RS11635	COG4651	solute:proton antiporter activity
FORC18_RS11635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC18_RS11640	COG0367	asparagine synthase
FORC18_RS11645	COG0250	Participates in transcription elongation, termination and antitermination
FORC18_RS11650	COG3104	oligopeptide transport
FORC18_RS11655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC18_RS11660	COG0563	adenylate kinase activity
FORC18_RS11665	COG0326	Molecular chaperone. Has ATPase activity
FORC18_RS11670	COG3710	Transcriptional regulator
FORC18_RS11690	COG0622	Phosphoesterase
FORC18_RS11720	COG1090	epimerase
FORC18_RS11725	COG0300	oxidoreductase activity
FORC18_RS11730	COG3118	belongs to the thioredoxin family
FORC18_RS11735	COG0330	HflC and HflK could
FORC18_RS11760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC18_RS11765	COG3115	cell septum assembly
FORC18_RS11770	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC18_RS11775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC18_RS11785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_RS11790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC18_RS11795	COG2190	(PTS) system
FORC18_RS11800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_RS11805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_RS11815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_RS11820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_RS11830	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC18_RS11830	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC18_RS11835	COG1706	bacterial-type flagellum-dependent cell motility
FORC18_RS11840	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC18_RS11850	COG4787	bacterial-type flagellum-dependent cell motility
FORC18_RS11855	COG1749	Flagellar hook protein flgE
FORC18_RS11865	COG1558	bacterial-type flagellum-dependent cell motility
FORC18_RS11870	COG1815	bacterial-type flagellum-dependent cell motility
FORC18_RS11875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC18_RS11880	COG0784	Response regulator, receiver
FORC18_RS11880	COG0835	chemotaxis
FORC18_RS11930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC18_RS11935	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC18_RS11945	COG2608	mercury ion transmembrane transporter activity
FORC18_RS11945	COG2217	Heavy metal translocating P-type atpase
FORC18_RS11980	COG2840	Smr protein MutS2
FORC18_RS11985	COG1187	pseudouridine synthase activity
FORC18_RS11995	COG0737	Belongs to the 5'-nucleotidase family
FORC18_RS12000	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC18_RS12005	COG2912	Transglutaminase-like superfamily
FORC18_RS12010	COG3094	Invasion gene expression up-regulator, SirB
FORC18_RS12015	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC18_RS12020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC18_RS12025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC18_RS12030	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC18_RS12035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC18_RS12040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC18_RS12045	COG0193	aminoacyl-tRNA hydrolase activity
FORC18_RS12050	COG0012	GTP binding
FORC18_RS12165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC18_RS12170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC18_RS12175	COG1702	phosphate starvation-inducible protein PhoH
FORC18_RS12180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC18_RS12185	COG4535	Mg2 and Co2 transporter CorC
FORC18_RS12190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC18_RS12195	COG2888	peptidyl-tyrosine sulfation
FORC18_RS12200	COG0495	leucyl-tRNA aminoacylation
FORC18_RS12205	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC18_RS12210	COG1466	dna polymerase III delta subunit
FORC18_RS12215	COG0799	negative regulation of ribosome biogenesis
FORC18_RS12220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC18_RS12225	COG0768	penicillin binding
FORC18_RS12230	COG0772	Belongs to the SEDS family
FORC18_RS12235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC18_RS12240	COG1686	Belongs to the peptidase S11 family
FORC18_RS12245	COG2921	Belongs to the UPF0250 family
FORC18_RS12250	COG0321	lipoyl(octanoyl) transferase activity
FORC18_RS12255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC18_RS12260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC18_RS12265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC18_RS12280	COG0366	Alpha amylase catalytic
FORC18_RS12285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC18_RS12285	COG1263	PTS System
FORC18_RS12295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC18_RS12300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC18_RS12305	COG2011	ABC-type metal ion transport system permease component
FORC18_RS12310	COG1464	Belongs to the NlpA lipoprotein family
FORC18_RS12315	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC18_RS12325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC18_RS12325	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC18_RS12340	COG1611	Belongs to the LOG family
FORC18_RS12345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC18_RS12355	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC18_RS12360	COG2363	Small membrane protein
FORC18_RS12370	COG0583	DNA-binding transcription factor activity
FORC18_RS12375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC18_RS12375	COG0301	tRNA thio-modification
FORC18_RS12380	COG2885	chlorophyll binding
FORC18_RS12385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC18_RS12390	COG1722	exodeoxyribonuclease VII activity
FORC18_RS12395	COG0142	geranyltranstransferase activity
FORC18_RS12400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC18_RS12405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC18_RS12410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC18_RS12415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC18_RS12435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC18_RS12435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC18_RS12440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC18_RS12445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC18_RS12450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC18_RS12460	COG1073	alpha beta
FORC18_RS12465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC18_RS12470	COG2252	PERMEase
FORC18_RS12475	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC18_RS12500	COG0047	phosphoribosylformylglycinamidine synthase activity
FORC18_RS12500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC18_RS12505	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC18_RS12520	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC18_RS12545	COG4969	Belongs to the N-Me-Phe pilin family
FORC18_RS12555	COG0484	heat shock protein binding
FORC18_RS12560	COG0443	Heat shock 70 kDa protein
FORC18_RS12570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC18_RS12575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC18_RS12585	COG0497	DNA recombination
FORC18_RS12590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC18_RS12595	COG2914	Belongs to the UPF0125 (RnfH) family
FORC18_RS12600	COG2867	negative regulation of translational initiation
FORC18_RS12605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC18_RS12615	COG0582	viral genome integration into host DNA
FORC18_RS12650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FORC18_RS12660	COG1401	restriction endodeoxyribonuclease activity
FORC18_RS12730	COG0583	DNA-binding transcription factor activity
FORC18_RS12735	COG3153	acetyltransferase
FORC18_RS12735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC18_RS12755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC18_RS12760	COG2873	o-acetylhomoserine
FORC18_RS12790	COG1115	amino acid carrier protein
FORC18_RS12800	COG1584	GPR1 FUN34 yaaH family protein
FORC18_RS12810	COG1757	Na H antiporter
FORC18_RS12815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC18_RS12815	COG0519	Catalyzes the synthesis of GMP from XMP
FORC18_RS12820	COG0517	IMP dehydrogenase activity
FORC18_RS12820	COG0516	GMP reductase activity
FORC18_RS12825	COG1570	exodeoxyribonuclease VII activity
FORC18_RS12840	COG1160	GTP binding
FORC18_RS12845	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC18_RS12850	COG2976	Protein conserved in bacteria
FORC18_RS12855	COG0124	histidyl-tRNA synthetase
FORC18_RS12860	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC18_RS12870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC18_RS12875	COG0105	UTP biosynthetic process
FORC18_RS12880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC18_RS12885	COG2975	iron-sulfur cluster assembly
FORC18_RS12890	COG0633	Ferredoxin
FORC18_RS12895	COG0443	Heat shock 70 kDa protein
FORC18_RS12900	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC18_RS12910	COG0822	iron-sulfur transferase activity
FORC18_RS12915	COG1104	cysteine desulfurase activity
FORC18_RS12930	COG0483	inositol monophosphate 1-phosphatase activity
FORC18_RS12935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC18_RS12940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC18_RS12945	COG1862	Preprotein translocase
FORC18_RS12950	COG0343	queuine tRNA-ribosyltransferase activity
FORC18_RS12955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC18_RS12970	COG0517	IMP dehydrogenase activity
FORC18_RS12980	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC18_RS12985	COG0583	DNA-binding transcription factor activity
FORC18_RS12990	COG0450	alkyl hydroperoxide reductase
FORC18_RS13000	COG3142	Participates in the control of copper homeostasis
FORC18_RS13010	COG0704	Plays a role in the regulation of phosphate uptake
FORC18_RS13015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC18_RS13020	COG0581	inorganic phosphate transmembrane transporter activity
FORC18_RS13030	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC18_RS13035	COG0248	Ppx GppA phosphatase
FORC18_RS13045	COG5002	protein histidine kinase activity
FORC18_RS13050	COG0745	RESPONSE REGULATOR receiver
FORC18_RS13060	COG2974	May be involved in recombination
FORC18_RS13065	COG0826	peptidase U32
FORC18_RS13070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC18_RS13125	COG0542	response to heat
FORC18_RS13130	COG1496	oxidoreductase activity
FORC18_RS13135	COG0564	pseudouridine synthase activity
FORC18_RS13140	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC18_RS13145	COG0741	lytic transglycosylase activity
FORC18_RS13150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC18_RS13155	COG0077	Prephenate dehydratase
FORC18_RS13155	COG1605	Chorismate mutase
FORC18_RS13160	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC18_RS13165	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC18_RS13175	COG0488	(ABC) transporter
FORC18_RS13190	COG0739	heme binding
FORC18_RS13195	COG1605	Chorismate mutase
FORC18_RS13195	COG0287	Prephenate dehydrogenase
FORC18_RS13200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC18_RS13205	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC18_RS13210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC18_RS13215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC18_RS13230	COG1966	Carbon starvation protein
FORC18_RS13235	COG3275	phosphorelay sensor kinase activity
FORC18_RS13240	COG3279	Response regulator of the LytR AlgR family
FORC18_RS13245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC18_RS13250	COG1047	Peptidyl-prolyl cis-trans
FORC18_RS13255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC18_RS13260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC18_RS13265	COG0196	riboflavin kinase activity
FORC18_RS13270	COG0728	peptidoglycan biosynthetic process
FORC18_RS13275	COG0268	Binds directly to 16S ribosomal RNA
FORC18_RS13280	COG0640	Transcriptional regulator
FORC18_RS13285	COG0583	DNA-binding transcription factor activity
FORC18_RS13290	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC18_RS13300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC18_RS13305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC18_RS13310	COG0730	response to heat
FORC18_RS13320	COG0494	nUDIX hydrolase
FORC18_RS13325	COG3066	DNA modification
FORC18_RS13335	COG0667	Aldo Keto reductase
FORC18_RS13345	COG2204	response regulator
FORC18_RS13350	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC18_RS13355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC18_RS13360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC18_RS13365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC18_RS13370	COG4974	Belongs to the 'phage' integrase family
FORC18_RS13375	COG0716	FMN binding
FORC18_RS13385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC18_RS13390	COG0513	Belongs to the DEAD box helicase family
FORC18_RS13395	COG3022	response to hydroperoxide
FORC18_RS13400	COG1115	amino acid carrier protein
FORC18_RS13415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC18_RS13420	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC18_RS13425	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC18_RS13430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC18_RS13435	COG0083	homoserine kinase activity
FORC18_RS13455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC18_RS13465	COG0745	RESPONSE REGULATOR receiver
FORC18_RS13475	COG5002	protein histidine kinase activity
FORC18_RS13475	COG2198	Histidine kinase
FORC18_RS13475	COG0784	Response regulator, receiver
FORC18_RS13480	COG4251	negative regulation of phosphorylation
FORC18_RS13480	COG3706	GGDEF domain
FORC18_RS13480	COG5001	Diguanylate cyclase
FORC18_RS13480	COG2203	Gaf domain
FORC18_RS13485	COG1242	4 iron, 4 sulfur cluster binding
FORC18_RS13490	COG0070	glutamate synthase
FORC18_RS13490	COG0069	glutamate synthase activity
FORC18_RS13490	COG0067	glutamate synthase
FORC18_RS13500	COG0069	glutamate synthase activity
FORC18_RS13500	COG0067	glutamate synthase
FORC18_RS13500	COG0070	glutamate synthase
FORC18_RS13505	COG0493	'glutamate synthase
FORC18_RS13515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC18_RS13525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC18_RS13530	COG2860	membrane
FORC18_RS13535	COG0583	DNA-binding transcription factor activity
FORC18_RS13540	COG0730	response to heat
FORC18_RS13555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC18_RS13560	COG0505	Belongs to the CarA family
FORC18_RS13565	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC18_RS13570	COG0494	nUDIX hydrolase
FORC18_RS13575	COG0653	protein targeting
FORC18_RS13585	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORC18_RS13590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC18_RS13595	COG0849	cell division
FORC18_RS13600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC18_RS13605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC18_RS13610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC18_RS13615	COG0772	Belongs to the SEDS family
FORC18_RS13620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC18_RS13625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC18_RS13630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC18_RS13635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC18_RS13640	COG0768	penicillin binding
FORC18_RS13645	COG3116	cell division
FORC18_RS13650	COG0275	rRNA processing
FORC18_RS13660	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC18_RS13670	COG0792	nuclease activity
FORC18_RS13675	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC18_RS13680	COG2823	Periplasmic or secreted lipoprotein
FORC18_RS13685	COG2969	positive regulation of protein catabolic process
FORC18_RS13690	COG0625	glutathione transferase activity
FORC18_RS13695	COG2857	Cytochrome c1
FORC18_RS13700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC18_RS13705	COG0723	plastoquinol--plastocyanin reductase activity
FORC18_RS13710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC18_RS13715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC18_RS13720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC18_RS13725	COG3105	Protein conserved in bacteria
FORC18_RS13735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC18_RS13740	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC18_RS13750	COG3150	esterase
FORC18_RS13760	COG3151	Protein conserved in bacteria
FORC18_RS13765	COG0494	nUDIX hydrolase
FORC18_RS13770	COG1538	Outer membrane efflux protein
FORC18_RS13775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC18_RS13775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC18_RS13780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC18_RS13795	COG3025	triphosphatase activity
FORC18_RS13800	COG1392	Phosphate transport regulator
FORC18_RS13805	COG0306	phosphate transporter
FORC18_RS13810	COG4991	sh3 domain protein
FORC18_RS13820	COG3409	Peptidoglycan-binding domain 1 protein
FORC18_RS13820	COG3267	Type II secretory pathway component ExeA
FORC18_RS13825	COG0617	tRNA 3'-terminal CCA addition
FORC18_RS13830	COG1968	undecaprenyl-diphosphatase activity
FORC18_RS13835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC18_RS13840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC18_RS13845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC18_RS13850	COG0596	Alpha beta hydrolase
FORC18_RS13855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC18_RS13860	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC18_RS13865	COG1610	YqeY-like protein
FORC18_RS13870	COG0358	DNA primase activity
FORC18_RS13885	COG1464	Belongs to the NlpA lipoprotein family
FORC18_RS13915	COG2213	PTS system mannitol-specific
FORC18_RS13915	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_RS13920	COG0246	Mannitol dehydrogenase
FORC18_RS13925	COG3722	fumarate hydratase activity
FORC18_RS13930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC18_RS13935	COG5002	protein histidine kinase activity
FORC18_RS13950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC18_RS13955	COG1349	DNA-binding transcription factor activity
FORC18_RS13960	COG0469	pyruvate kinase activity
FORC18_RS13975	COG0440	acetolactate synthase activity
FORC18_RS13980	COG0028	Belongs to the TPP enzyme family
FORC18_RS13985	COG1022	Amp-dependent synthetase and ligase
FORC18_RS13990	COG0583	DNA-binding transcription factor activity
FORC18_RS14010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC18_RS14015	COG0473	3-isopropylmalate dehydrogenase activity
FORC18_RS14020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC18_RS14025	COG0066	3-isopropylmalate dehydratase activity
FORC18_RS14035	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC18_RS14040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC18_RS14045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC18_RS14050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC18_RS14055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC18_RS14060	COG2967	ApaG domain
FORC18_RS14065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC18_RS14080	COG2966	Psort location CytoplasmicMembrane, score
FORC18_RS14085	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC18_RS14095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC18_RS14100	COG0142	geranyltranstransferase activity
FORC18_RS14110	COG0039	L-malate dehydrogenase activity
FORC18_RS14120	COG2358	TRAP transporter, solute receptor (TAXI family
FORC18_RS14135	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC18_RS14140	COG1178	ABC-type Fe3 transport system permease component
FORC18_RS14145	COG4143	(ABC) transporter
FORC18_RS14150	COG0163	prenyltransferase activity
FORC18_RS14155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC18_RS14160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC18_RS14165	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC18_RS14175	COG2105	PFAM AIG2 family protein
FORC18_RS14185	COG0729	surface antigen
FORC18_RS14190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC18_RS14200	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC18_RS14215	COG4181	ATPase activity
FORC18_RS14235	COG0529	Catalyzes the synthesis of activated sulfate
FORC18_RS14240	COG3273	potassium ion transport
FORC18_RS14240	COG0471	metal ion transport
FORC18_RS14245	COG2895	sulfate adenylyltransferase (ATP) activity
FORC18_RS14250	COG0175	sulfate reduction
FORC18_RS14255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC18_RS14255	COG1648	precorrin-2 dehydrogenase activity
FORC18_RS14260	COG0737	Belongs to the 5'-nucleotidase family
FORC18_RS14270	COG0513	Belongs to the DEAD box helicase family
FORC18_RS14275	COG2153	protein acetylation
FORC18_RS14285	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC18_RS14295	COG0203	ribosomal protein L17
FORC18_RS14300	COG0202	RNA polymerase activity
FORC18_RS14310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC18_RS14315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC18_RS14320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FORC18_RS14325	COG0201	protein transport
FORC18_RS14330	COG0200	Binds to the 23S rRNA
FORC18_RS14335	COG1841	ribosomal large subunit assembly
FORC18_RS14350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC18_RS14355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC18_RS14360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC18_RS14365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC18_RS14370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC18_RS14375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC18_RS14380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC18_RS14385	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC18_RS14395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC18_RS14400	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC18_RS14405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC18_RS14410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC18_RS14420	COG0088	Forms part of the polypeptide exit tunnel
FORC18_RS14425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC18_RS14435	COG0254	rRNA binding
FORC18_RS14440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC18_RS14445	COG1609	Transcriptional regulator
FORC18_RS14455	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC18_RS14460	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC18_RS14465	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC18_RS14470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC18_RS14475	COG3074	FtsZ-dependent cytokinesis
FORC18_RS14480	COG1494	fructose-1,6-bisphosphatase
FORC18_RS14505	COG0149	triose-phosphate isomerase activity
FORC18_RS14530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC18_RS14545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC18_RS14560	COG2244	polysaccharide biosynthetic process
FORC18_RS14585	COG2089	acid synthase
FORC18_RS14590	COG1083	cytidylyl-transferase
FORC18_RS14625	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC18_RS14635	COG1560	Kdo2-lipid A biosynthetic process
FORC18_RS14640	COG0859	PFAM glycosyl transferase family 9
FORC18_RS14645	COG1519	Transferase
FORC18_RS14670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC18_RS14675	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_RS14685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC18_RS14715	COG3642	lipopolysaccharide core region biosynthetic process
FORC18_RS14720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC18_RS14725	COG0859	PFAM glycosyl transferase family 9
FORC18_RS14730	COG0463	Glycosyl transferase, family 2
FORC18_RS14745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC18_RS14750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC18_RS14765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC18_RS14770	COG2003	Belongs to the UPF0758 family
FORC18_RS14775	COG0840	transmembrane signaling receptor activity
FORC18_RS14780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC18_RS14785	COG1309	transcriptional regulator
FORC18_RS14790	COG1560	Kdo2-lipid A biosynthetic process
FORC18_RS14795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC18_RS14800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC18_RS14805	COG1561	YicC-like family, N-terminal region
FORC18_RS14815	COG4608	Belongs to the ABC transporter superfamily
FORC18_RS14820	COG0444	Belongs to the ABC transporter superfamily
FORC18_RS14825	COG0747	negative chemotaxis
FORC18_RS14830	COG4239	(ABC) transporter, permease
FORC18_RS14835	COG4174	ABC transporter (Permease)
FORC18_RS14855	COG0811	peptide transport
FORC18_RS14860	COG0848	biopolymer transport protein
FORC18_RS14875	COG0194	GDP metabolic process
FORC18_RS14880	COG1758	RNA polymerase activity
FORC18_RS14885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC18_RS14890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC18_RS14895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC18_RS14905	COG2233	PERMEase
FORC18_RS14925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC18_RS14935	COG2183	response to ionizing radiation
FORC18_RS14945	COG0596	Alpha beta hydrolase
FORC18_RS14950	COG1040	competence protein
FORC18_RS14955	COG0316	Belongs to the HesB IscA family
FORC18_RS14955	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC18_RS14960	COG0494	nUDIX hydrolase
FORC18_RS14965	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC18_RS14975	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC18_RS14980	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC18_RS14985	COG3156	type II secretion system protein K
FORC18_RS14990	COG4795	General secretion pathway protein
FORC18_RS14995	COG2165	general secretion pathway protein
FORC18_RS15000	COG2165	general secretion pathway protein
FORC18_RS15005	COG2165	general secretion pathway protein
FORC18_RS15010	COG1459	type II secretion system
FORC18_RS15015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC18_RS15025	COG3031	protein transport across the cell outer membrane
FORC18_RS15030	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC18_RS15035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC18_RS15040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC18_RS15050	COG0456	acetyltransferase
FORC18_RS15055	COG1490	D-aminoacyl-tRNA deacylase activity
FORC18_RS15060	COG1295	ribonuclease BN
FORC18_RS15075	COG1217	gtp-binding protein TYPA
FORC18_RS15085	COG0174	glutamine synthetase
FORC18_RS15095	COG3852	Histidine kinase
FORC18_RS15100	COG2204	response regulator
FORC18_RS15110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC18_RS15150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC18_RS15155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC18_RS15155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC18_RS15170	COG0084	hydrolase, TatD family'
FORC18_RS15175	COG0805	protein transport
FORC18_RS15180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC18_RS15185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC18_RS15190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC18_RS15195	COG3165	ubiquinone biosynthetic process from chorismate
FORC18_RS15200	COG2226	methyltransferase
FORC18_RS15205	COG1322	Protein conserved in bacteria
FORC18_RS15220	COG0628	permease
FORC18_RS15270	COG2823	Periplasmic or secreted lipoprotein
FORC18_RS15280	COG2081	HI0933 family
FORC18_RS15290	COG1528	Iron-storage protein
FORC18_RS15295	COG0589	response to stress
FORC18_RS15310	COG0742	ribosomal rna small subunit methyltransferase
FORC18_RS15315	COG5001	Diguanylate cyclase
FORC18_RS15315	COG5002	protein histidine kinase activity
FORC18_RS15320	COG1522	sequence-specific DNA binding
FORC18_RS15325	COG0339	signal peptide processing
FORC18_RS15330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC18_RS15335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC18_RS15340	COG0583	DNA-binding transcription factor activity
FORC18_RS15345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC18_RS15350	COG0800	Aldolase
FORC18_RS15355	COG2610	gluconate transmembrane transporter activity
FORC18_RS15360	COG3265	gluconokinase activity
FORC18_RS15365	COG0129	dihydroxy-acid dehydratase activity
FORC18_RS15380	COG0583	DNA-binding transcription factor activity
FORC18_RS15385	COG1609	Transcriptional regulator
FORC18_RS15420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC18_RS15425	COG0601	transmembrane transport
FORC18_RS15430	COG0747	negative chemotaxis
FORC18_RS15435	COG4172	Belongs to the ABC transporter superfamily
FORC18_RS15490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_RS15495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC18_RS15500	COG2960	long-chain fatty acid transporting porin activity
FORC18_RS15505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC18_RS15510	COG0583	DNA-binding transcription factor activity
FORC18_RS15545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC18_RS15555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC18_RS15560	COG0408	coproporphyrinogen oxidase activity
FORC18_RS15565	COG0009	L-threonylcarbamoyladenylate synthase
FORC18_RS15570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC18_RS15575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC18_RS15580	COG0551	DNA topoisomerase type I activity
FORC18_RS15585	COG2922	Belongs to the Smg family
FORC18_RS15590	COG0758	DNA mediated transformation
FORC18_RS15600	COG0242	peptide deformylase activity
FORC18_RS15605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC18_RS15610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC18_RS15610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC18_RS15615	COG0569	domain protein
FORC18_RS15620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC18_RS15630	COG1272	protein, Hemolysin III
FORC18_RS15635	COG4326	sporulation control protein
FORC18_RS15640	COG3084	Protein conserved in bacteria
FORC18_RS15650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC18_RS15655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC18_RS15660	COG0204	Acyl-transferase
FORC18_RS15670	COG0606	chelatase, subunit chli
FORC18_RS15680	COG3978	acetolactate synthase activity
FORC18_RS15685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC18_RS15690	COG0129	dihydroxy-acid dehydratase activity
FORC18_RS15700	COG0583	DNA-binding transcription factor activity
FORC18_RS15705	COG2814	Major facilitator Superfamily
FORC18_RS15710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_RS15715	COG0765	amino acid transport
FORC18_RS15720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC18_RS15725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC18_RS15730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC18_RS15735	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORC18_RS15740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC18_RS15745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC18_RS15760	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC18_RS15765	COG3312	ion transport
FORC18_RS15770	COG1475	DNA binding
FORC18_RS15775	COG1192	Involved in chromosome partitioning
FORC18_RS15780	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC18_RS15785	COG0445	tRNA wobble uridine modification
FORC18_RS15790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC18_RS15795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC18_RS15820	COG1126	abc transporter atp-binding protein
FORC18_RS15995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC18_RS16150	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC18_RS16580	COG0085	RNA polymerase activity
FORC18_RS16600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC18_RS16770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC18_RS16775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC18_RS16910	COG2205	protein histidine kinase activity
FORC18_RS16980	COG1053	succinate dehydrogenase
FORC18_RS17120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC18_RS17225	COG3138	arginine N-succinyltransferase
FORC18_RS17370	COG0527	aspartate kinase activity
FORC18_RS17370	COG0460	homoserine dehydrogenase
FORC18_RS17490	COG4796	Type ii and iii secretion system protein
FORC18_RS17660	COG0646	methionine synthase
FORC18_RS17660	COG1410	methionine synthase
FORC18_RS18020	COG0525	valine-tRNA ligase activity
FORC18_RS18220	COG4771	TonB-dependent receptor
FORC18_RS18225	COG4771	TonB-dependent receptor
FORC18_RS18270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC18_RS18330	COG3026	antisigma factor binding
FORC18_RS18685	COG1131	(ABC) transporter
FORC18_RS19205	COG2017	converts alpha-aldose to the beta-anomer
FORC18_RS19320	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC18_RS19445	COG1805	sodium ion transport
FORC18_RS19630	COG0575	Belongs to the CDS family
FORC18_RS19850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC18_RS19880	COG4191	Histidine kinase
FORC18_RS20080	COG1025	Belongs to the peptidase M16 family
FORC18_RS20140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC18_RS20140	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC18_RS20160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC18_RS20505	COG4659	FMN binding
FORC18_RS20730	COG1530	ribonuclease E activity
FORC18_RS20730	COG1530	ribonuclease E activity
FORC18_RS20825	COG0733	neurotransmitter:sodium symporter activity
FORC18_RS20865	COG0587	DNA-directed DNA polymerase activity
FORC18_RS20875	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_RS20960	COG2995	paraquat-inducible protein a
FORC18_RS21130	COG1032	radical SAM domain protein
FORC18_RS21225	COG0133	tryptophan synthase activity
FORC18_RS21230	COG0135	phosphoribosylanthranilate isomerase activity
FORC18_RS21230	COG0134	indole-3-glycerol-phosphate synthase activity
FORC18_RS21255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC18_RS21290	COG0417	DNA replication proofreading
FORC18_RS21300	COG0322	excinuclease ABC activity
FORC18_RS21470	COG1138	Cytochrome C-type biogenesis protein
FORC18_RS21655	COG1760	l-serine dehydratase
FORC18_RS22290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC18_RS22310	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_RS22380	COG2205	protein histidine kinase activity
FORC18_RS22380	COG3437	response regulator, receiver
FORC18_RS22380	COG4999	Histidine kinase
FORC18_RS22380	COG3850	Histidine kinase
FORC18_RS22475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC18_RS23000	COG0765	amino acid transport
FORC18_RS23110	COG0308	aminopeptidase N
FORC18_RS23120	COG0308	aminopeptidase N
FORC18_RS23770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain