locus-tag	class	description
FORC22_RS00010	COG0592	DNA-directed DNA polymerase activity
FORC22_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC22_RS00020	COG0187	DNA topoisomerase II activity
FORC22_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC22_RS00035	COG3977	Valine--pyruvate aminotransferase
FORC22_RS00040	COG0366	Alpha amylase catalytic
FORC22_RS00045	COG0751	glycine-tRNA ligase activity
FORC22_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
FORC22_RS00055	COG2119	membrane
FORC22_RS00065	COG0425	Belongs to the sulfur carrier protein TusA family
FORC22_RS00080	COG0604	alcohol dehydrogenase
FORC22_RS00085	COG0183	Belongs to the thiolase family
FORC22_RS00090	COG1024	Enoyl-CoA hydratase
FORC22_RS00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC22_RS00095	COG1739	Uncharacterized protein family UPF0029
FORC22_RS00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC22_RS00140	COG0583	DNA-binding transcription factor activity
FORC22_RS00145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC22_RS00150	COG2960	long-chain fatty acid transporting porin activity
FORC22_RS00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_RS00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_RS00215	COG4172	Belongs to the ABC transporter superfamily
FORC22_RS00220	COG0747	negative chemotaxis
FORC22_RS00225	COG0601	transmembrane transport
FORC22_RS00230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC22_RS00265	COG1609	Transcriptional regulator
FORC22_RS00270	COG0583	DNA-binding transcription factor activity
FORC22_RS00285	COG0129	dihydroxy-acid dehydratase activity
FORC22_RS00290	COG3265	gluconokinase activity
FORC22_RS00295	COG2610	gluconate transmembrane transporter activity
FORC22_RS00300	COG0800	Aldolase
FORC22_RS00305	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC22_RS00310	COG0583	DNA-binding transcription factor activity
FORC22_RS00315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC22_RS00320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC22_RS00325	COG0339	signal peptide processing
FORC22_RS00330	COG1522	sequence-specific DNA binding
FORC22_RS00335	COG5002	protein histidine kinase activity
FORC22_RS00335	COG5001	Diguanylate cyclase
FORC22_RS00340	COG0742	ribosomal rna small subunit methyltransferase
FORC22_RS00355	COG0589	response to stress
FORC22_RS00360	COG1528	Iron-storage protein
FORC22_RS00370	COG2081	HI0933 family
FORC22_RS00380	COG2823	Periplasmic or secreted lipoprotein
FORC22_RS00430	COG0628	permease
FORC22_RS00445	COG1322	Protein conserved in bacteria
FORC22_RS00450	COG2226	methyltransferase
FORC22_RS00455	COG3165	ubiquinone biosynthetic process from chorismate
FORC22_RS00460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC22_RS00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC22_RS00470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC22_RS00475	COG0805	protein transport
FORC22_RS00480	COG0084	hydrolase, TatD family'
FORC22_RS00495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC22_RS00495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC22_RS00500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC22_RS00540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC22_RS00550	COG2204	response regulator
FORC22_RS00555	COG3852	Histidine kinase
FORC22_RS00565	COG0174	glutamine synthetase
FORC22_RS00575	COG1217	gtp-binding protein TYPA
FORC22_RS00590	COG1295	ribonuclease BN
FORC22_RS00595	COG1490	D-aminoacyl-tRNA deacylase activity
FORC22_RS00600	COG0456	acetyltransferase
FORC22_RS00610	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC22_RS00615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC22_RS00620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC22_RS00625	COG3031	protein transport across the cell outer membrane
FORC22_RS00635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC22_RS00640	COG1459	type II secretion system
FORC22_RS00645	COG2165	general secretion pathway protein
FORC22_RS00650	COG2165	general secretion pathway protein
FORC22_RS00655	COG2165	general secretion pathway protein
FORC22_RS00660	COG4795	General secretion pathway protein
FORC22_RS00665	COG3156	type II secretion system protein K
FORC22_RS00670	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC22_RS00675	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC22_RS00685	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC22_RS00690	COG0494	nUDIX hydrolase
FORC22_RS00695	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC22_RS00695	COG0316	Belongs to the HesB IscA family
FORC22_RS00700	COG1040	competence protein
FORC22_RS00705	COG0596	Alpha beta hydrolase
FORC22_RS00715	COG2183	response to ionizing radiation
FORC22_RS00725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC22_RS00745	COG2233	PERMEase
FORC22_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC22_RS00760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC22_RS00765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC22_RS00770	COG1758	RNA polymerase activity
FORC22_RS00775	COG0194	GDP metabolic process
FORC22_RS00790	COG0848	biopolymer transport protein
FORC22_RS00795	COG0811	peptide transport
FORC22_RS00815	COG4174	ABC transporter (Permease)
FORC22_RS00820	COG4239	(ABC) transporter, permease
FORC22_RS00825	COG0747	negative chemotaxis
FORC22_RS00830	COG0444	Belongs to the ABC transporter superfamily
FORC22_RS00835	COG4608	Belongs to the ABC transporter superfamily
FORC22_RS00845	COG1561	YicC-like family, N-terminal region
FORC22_RS00850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC22_RS00855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC22_RS00860	COG1560	Kdo2-lipid A biosynthetic process
FORC22_RS00865	COG1309	transcriptional regulator
FORC22_RS00870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC22_RS00875	COG0840	transmembrane signaling receptor activity
FORC22_RS00880	COG2003	Belongs to the UPF0758 family
FORC22_RS00885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC22_RS00895	COG2194	sulfuric ester hydrolase activity
FORC22_RS00905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC22_RS00910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC22_RS00925	COG0463	Glycosyl transferase, family 2
FORC22_RS00930	COG0859	PFAM glycosyl transferase family 9
FORC22_RS00935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC22_RS00940	COG3642	lipopolysaccharide core region biosynthetic process
FORC22_RS00950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC22_RS00955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FORC22_RS00960	COG2089	acid synthase
FORC22_RS00970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC22_RS00985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC22_RS00995	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_RS01015	COG1519	Transferase
FORC22_RS01020	COG0859	PFAM glycosyl transferase family 9
FORC22_RS01025	COG1560	Kdo2-lipid A biosynthetic process
FORC22_RS01035	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC22_RS01070	COG0438	transferase activity, transferring glycosyl groups
FORC22_RS01095	COG2755	lipolytic protein G-D-S-L family
FORC22_RS01095	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FORC22_RS01105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC22_RS01125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FORC22_RS01130	COG0149	triose-phosphate isomerase activity
FORC22_RS01155	COG1494	fructose-1,6-bisphosphatase
FORC22_RS01160	COG3074	FtsZ-dependent cytokinesis
FORC22_RS01165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC22_RS01170	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC22_RS01175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC22_RS01180	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC22_RS01190	COG1609	Transcriptional regulator
FORC22_RS01195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC22_RS01200	COG0254	rRNA binding
FORC22_RS01210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC22_RS01215	COG0088	Forms part of the polypeptide exit tunnel
FORC22_RS01225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC22_RS01230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC22_RS01235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC22_RS01240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC22_RS01250	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC22_RS01255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC22_RS01260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC22_RS01265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC22_RS01270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC22_RS01275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC22_RS01280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC22_RS01285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC22_RS01300	COG1841	ribosomal large subunit assembly
FORC22_RS01305	COG0200	Binds to the 23S rRNA
FORC22_RS01310	COG0201	protein transport
FORC22_RS01315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FORC22_RS01320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC22_RS01325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC22_RS01335	COG0202	RNA polymerase activity
FORC22_RS01340	COG0203	ribosomal protein L17
FORC22_RS01350	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC22_RS01360	COG2153	protein acetylation
FORC22_RS01365	COG0513	Belongs to the DEAD box helicase family
FORC22_RS01375	COG0737	Belongs to the 5'-nucleotidase family
FORC22_RS01380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC22_RS01380	COG1648	precorrin-2 dehydrogenase activity
FORC22_RS01385	COG0175	sulfate reduction
FORC22_RS01390	COG2895	sulfate adenylyltransferase (ATP) activity
FORC22_RS01395	COG0471	metal ion transport
FORC22_RS01395	COG3273	potassium ion transport
FORC22_RS01400	COG0529	Catalyzes the synthesis of activated sulfate
FORC22_RS01420	COG4181	ATPase activity
FORC22_RS01435	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC22_RS01445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC22_RS01450	COG0729	surface antigen
FORC22_RS01460	COG2105	PFAM AIG2 family protein
FORC22_RS01470	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC22_RS01475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC22_RS01480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC22_RS01485	COG0163	prenyltransferase activity
FORC22_RS01490	COG4143	(ABC) transporter
FORC22_RS01495	COG1178	ABC-type Fe3 transport system permease component
FORC22_RS01500	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC22_RS01515	COG2358	TRAP transporter, solute receptor (TAXI family
FORC22_RS01525	COG0039	L-malate dehydrogenase activity
FORC22_RS01535	COG0142	geranyltranstransferase activity
FORC22_RS01540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC22_RS01550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC22_RS01555	COG2966	Psort location CytoplasmicMembrane, score
FORC22_RS01570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC22_RS01575	COG2967	ApaG domain
FORC22_RS01580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC22_RS01585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC22_RS01590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC22_RS01595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC22_RS01600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC22_RS01610	COG0066	3-isopropylmalate dehydratase activity
FORC22_RS01615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC22_RS01620	COG0473	3-isopropylmalate dehydrogenase activity
FORC22_RS01625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC22_RS01650	COG0583	DNA-binding transcription factor activity
FORC22_RS01655	COG1022	Amp-dependent synthetase and ligase
FORC22_RS01660	COG0028	Belongs to the TPP enzyme family
FORC22_RS01665	COG0440	acetolactate synthase activity
FORC22_RS01680	COG0469	pyruvate kinase activity
FORC22_RS01685	COG1349	DNA-binding transcription factor activity
FORC22_RS01690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC22_RS01705	COG5002	protein histidine kinase activity
FORC22_RS01715	COG2376	Dihydroxyacetone kinase
FORC22_RS01720	COG1461	Dihydroxyacetone kinase
FORC22_RS01735	COG3722	fumarate hydratase activity
FORC22_RS01740	COG0246	Mannitol dehydrogenase
FORC22_RS01745	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_RS01745	COG2213	PTS system mannitol-specific
FORC22_RS01775	COG1464	Belongs to the NlpA lipoprotein family
FORC22_RS01900	COG3550	peptidyl-serine autophosphorylation
FORC22_RS01920	COG0358	DNA primase activity
FORC22_RS01925	COG1610	YqeY-like protein
FORC22_RS01930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC22_RS01935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC22_RS01940	COG0596	Alpha beta hydrolase
FORC22_RS01945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC22_RS01950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC22_RS01955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC22_RS01960	COG1968	undecaprenyl-diphosphatase activity
FORC22_RS01965	COG0617	tRNA 3'-terminal CCA addition
FORC22_RS01970	COG3409	Peptidoglycan-binding domain 1 protein
FORC22_RS01970	COG3267	Type II secretory pathway component ExeA
FORC22_RS01980	COG4991	sh3 domain protein
FORC22_RS01985	COG0306	phosphate transporter
FORC22_RS01990	COG1392	Phosphate transport regulator
FORC22_RS01995	COG3025	triphosphatase activity
FORC22_RS02010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC22_RS02015	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC22_RS02015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC22_RS02020	COG1538	Outer membrane efflux protein
FORC22_RS02025	COG0494	nUDIX hydrolase
FORC22_RS02030	COG3151	Protein conserved in bacteria
FORC22_RS02040	COG3150	esterase
FORC22_RS02050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC22_RS02055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC22_RS02065	COG3105	Protein conserved in bacteria
FORC22_RS02070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC22_RS02075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC22_RS02080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC22_RS02085	COG0723	plastoquinol--plastocyanin reductase activity
FORC22_RS02090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC22_RS02095	COG2857	Cytochrome c1
FORC22_RS02100	COG0625	glutathione transferase activity
FORC22_RS02105	COG2969	positive regulation of protein catabolic process
FORC22_RS02110	COG2823	Periplasmic or secreted lipoprotein
FORC22_RS02115	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC22_RS02120	COG0792	nuclease activity
FORC22_RS02130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC22_RS02140	COG0275	rRNA processing
FORC22_RS02145	COG3116	cell division
FORC22_RS02150	COG0768	penicillin binding
FORC22_RS02155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC22_RS02160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC22_RS02165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC22_RS02170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC22_RS02175	COG0772	Belongs to the SEDS family
FORC22_RS02180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC22_RS02185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC22_RS02190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC22_RS02195	COG0849	cell division
FORC22_RS02200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC22_RS02205	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORC22_RS02215	COG0653	protein targeting
FORC22_RS02220	COG0494	nUDIX hydrolase
FORC22_RS02225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC22_RS02230	COG0505	Belongs to the CarA family
FORC22_RS02235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC22_RS02250	COG0730	response to heat
FORC22_RS02255	COG0583	DNA-binding transcription factor activity
FORC22_RS02260	COG2860	membrane
FORC22_RS02265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC22_RS02275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC22_RS02285	COG0493	'glutamate synthase
FORC22_RS02290	COG0067	glutamate synthase
FORC22_RS02290	COG0069	glutamate synthase activity
FORC22_RS02290	COG0070	glutamate synthase
FORC22_RS02300	COG0070	glutamate synthase
FORC22_RS02300	COG0069	glutamate synthase activity
FORC22_RS02300	COG0067	glutamate synthase
FORC22_RS02305	COG1242	4 iron, 4 sulfur cluster binding
FORC22_RS02310	COG4251	negative regulation of phosphorylation
FORC22_RS02310	COG3706	GGDEF domain
FORC22_RS02310	COG2203	Gaf domain
FORC22_RS02310	COG5001	Diguanylate cyclase
FORC22_RS02315	COG5002	protein histidine kinase activity
FORC22_RS02315	COG2198	Histidine kinase
FORC22_RS02315	COG0784	Response regulator, receiver
FORC22_RS02325	COG0745	RESPONSE REGULATOR receiver
FORC22_RS02335	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC22_RS02355	COG0083	homoserine kinase activity
FORC22_RS02360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC22_RS02365	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC22_RS02370	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC22_RS02375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC22_RS02390	COG1115	amino acid carrier protein
FORC22_RS02395	COG3022	response to hydroperoxide
FORC22_RS02400	COG0513	Belongs to the DEAD box helicase family
FORC22_RS02405	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC22_RS02415	COG0716	FMN binding
FORC22_RS02420	COG4974	Belongs to the 'phage' integrase family
FORC22_RS02425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC22_RS02430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC22_RS02435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC22_RS02440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC22_RS02455	COG0667	Aldo Keto reductase
FORC22_RS02465	COG3066	DNA modification
FORC22_RS02470	COG0494	nUDIX hydrolase
FORC22_RS02480	COG0730	response to heat
FORC22_RS02485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC22_RS02490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC22_RS02500	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC22_RS02505	COG0583	DNA-binding transcription factor activity
FORC22_RS02510	COG0640	Transcriptional regulator
FORC22_RS02515	COG0268	Binds directly to 16S ribosomal RNA
FORC22_RS02520	COG0728	peptidoglycan biosynthetic process
FORC22_RS02525	COG0196	riboflavin kinase activity
FORC22_RS02530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC22_RS02535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC22_RS02540	COG1047	Peptidyl-prolyl cis-trans
FORC22_RS02545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC22_RS02550	COG3279	Response regulator of the LytR AlgR family
FORC22_RS02555	COG3275	phosphorelay sensor kinase activity
FORC22_RS02560	COG1966	Carbon starvation protein
FORC22_RS02575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC22_RS02580	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC22_RS02585	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC22_RS02590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC22_RS02595	COG0287	Prephenate dehydrogenase
FORC22_RS02595	COG1605	Chorismate mutase
FORC22_RS02600	COG0739	heme binding
FORC22_RS02615	COG0488	(ABC) transporter
FORC22_RS02625	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC22_RS02630	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC22_RS02635	COG0077	Prephenate dehydratase
FORC22_RS02635	COG1605	Chorismate mutase
FORC22_RS02640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC22_RS02645	COG0741	lytic transglycosylase activity
FORC22_RS02650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC22_RS02655	COG0564	pseudouridine synthase activity
FORC22_RS02665	COG0542	response to heat
FORC22_RS02720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC22_RS02725	COG0826	peptidase U32
FORC22_RS02730	COG2974	May be involved in recombination
FORC22_RS02740	COG0745	RESPONSE REGULATOR receiver
FORC22_RS02745	COG5002	protein histidine kinase activity
FORC22_RS02755	COG0248	Ppx GppA phosphatase
FORC22_RS02760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC22_RS02770	COG0581	inorganic phosphate transmembrane transporter activity
FORC22_RS02775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC22_RS02780	COG0704	Plays a role in the regulation of phosphate uptake
FORC22_RS02790	COG3142	Participates in the control of copper homeostasis
FORC22_RS02800	COG0450	alkyl hydroperoxide reductase
FORC22_RS02805	COG0583	DNA-binding transcription factor activity
FORC22_RS02810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC22_RS02820	COG0517	IMP dehydrogenase activity
FORC22_RS02835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC22_RS02840	COG0343	queuine tRNA-ribosyltransferase activity
FORC22_RS02845	COG1862	Preprotein translocase
FORC22_RS02850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC22_RS02855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC22_RS02860	COG0483	inositol monophosphate 1-phosphatase activity
FORC22_RS02875	COG1104	cysteine desulfurase activity
FORC22_RS02880	COG0822	iron-sulfur transferase activity
FORC22_RS02890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC22_RS02895	COG0443	Heat shock 70 kDa protein
FORC22_RS02900	COG0633	Ferredoxin
FORC22_RS02905	COG2975	iron-sulfur cluster assembly
FORC22_RS02910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC22_RS02915	COG0105	UTP biosynthetic process
FORC22_RS02920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC22_RS02930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC22_RS02935	COG0124	histidyl-tRNA synthetase
FORC22_RS02940	COG2976	Protein conserved in bacteria
FORC22_RS02945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC22_RS02950	COG1160	GTP binding
FORC22_RS02965	COG1570	exodeoxyribonuclease VII activity
FORC22_RS02970	COG0516	GMP reductase activity
FORC22_RS02970	COG0517	IMP dehydrogenase activity
FORC22_RS02975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC22_RS02975	COG0519	Catalyzes the synthesis of GMP from XMP
FORC22_RS02980	COG1757	Na H antiporter
FORC22_RS02990	COG1584	GPR1 FUN34 yaaH family protein
FORC22_RS03000	COG1115	amino acid carrier protein
FORC22_RS03030	COG2873	o-acetylhomoserine
FORC22_RS03035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC22_RS03055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC22_RS03055	COG3153	acetyltransferase
FORC22_RS03060	COG0583	DNA-binding transcription factor activity
FORC22_RS03115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC22_RS03120	COG2867	negative regulation of translational initiation
FORC22_RS03125	COG2914	Belongs to the UPF0125 (RnfH) family
FORC22_RS03130	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC22_RS03135	COG0497	DNA recombination
FORC22_RS03145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC22_RS03150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC22_RS03160	COG0443	Heat shock 70 kDa protein
FORC22_RS03165	COG0484	heat shock protein binding
FORC22_RS03195	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC22_RS03205	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC22_RS03210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC22_RS03210	COG0047	phosphoribosylformylglycinamidine synthase activity
FORC22_RS03235	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC22_RS03240	COG2252	PERMEase
FORC22_RS03245	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC22_RS03250	COG1073	alpha beta
FORC22_RS03260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC22_RS03265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC22_RS03270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC22_RS03275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC22_RS03275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC22_RS03295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC22_RS03300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC22_RS03305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC22_RS03310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC22_RS03315	COG0142	geranyltranstransferase activity
FORC22_RS03320	COG1722	exodeoxyribonuclease VII activity
FORC22_RS03325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC22_RS03330	COG2885	chlorophyll binding
FORC22_RS03335	COG0301	tRNA thio-modification
FORC22_RS03335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC22_RS03340	COG0583	DNA-binding transcription factor activity
FORC22_RS03350	COG2363	Small membrane protein
FORC22_RS03355	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC22_RS03365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC22_RS03370	COG1611	Belongs to the LOG family
FORC22_RS03385	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC22_RS03385	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC22_RS03395	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC22_RS03400	COG1464	Belongs to the NlpA lipoprotein family
FORC22_RS03405	COG2011	ABC-type metal ion transport system permease component
FORC22_RS03410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC22_RS03415	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC22_RS03425	COG1263	PTS System
FORC22_RS03425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC22_RS03430	COG0366	Alpha amylase catalytic
FORC22_RS03445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC22_RS03450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC22_RS03455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC22_RS03460	COG0321	lipoyl(octanoyl) transferase activity
FORC22_RS03465	COG2921	Belongs to the UPF0250 family
FORC22_RS03470	COG1686	Belongs to the peptidase S11 family
FORC22_RS03475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC22_RS03480	COG0772	Belongs to the SEDS family
FORC22_RS03485	COG0768	penicillin binding
FORC22_RS03490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC22_RS03495	COG0799	negative regulation of ribosome biogenesis
FORC22_RS03500	COG1466	dna polymerase III delta subunit
FORC22_RS03505	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC22_RS03510	COG0495	leucyl-tRNA aminoacylation
FORC22_RS03515	COG2888	peptidyl-tyrosine sulfation
FORC22_RS03520	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC22_RS03525	COG4535	Mg2 and Co2 transporter CorC
FORC22_RS03530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC22_RS03535	COG1702	phosphate starvation-inducible protein PhoH
FORC22_RS03540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC22_RS03545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC22_RS03660	COG0012	GTP binding
FORC22_RS03665	COG0193	aminoacyl-tRNA hydrolase activity
FORC22_RS03670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC22_RS03675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC22_RS03680	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC22_RS03685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC22_RS03690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC22_RS03695	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC22_RS03700	COG3094	Invasion gene expression up-regulator, SirB
FORC22_RS03705	COG2912	Transglutaminase-like superfamily
FORC22_RS03710	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC22_RS03715	COG0737	Belongs to the 5'-nucleotidase family
FORC22_RS03725	COG1187	pseudouridine synthase activity
FORC22_RS03730	COG2840	Smr protein MutS2
FORC22_RS03765	COG2217	Heavy metal translocating P-type atpase
FORC22_RS03765	COG2608	mercury ion transmembrane transporter activity
FORC22_RS03775	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC22_RS03780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC22_RS03830	COG0784	Response regulator, receiver
FORC22_RS03830	COG0835	chemotaxis
FORC22_RS03835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC22_RS03840	COG1815	bacterial-type flagellum-dependent cell motility
FORC22_RS03845	COG1558	bacterial-type flagellum-dependent cell motility
FORC22_RS03855	COG1749	Flagellar hook protein flgE
FORC22_RS03860	COG4787	bacterial-type flagellum-dependent cell motility
FORC22_RS03870	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC22_RS03875	COG1706	bacterial-type flagellum-dependent cell motility
FORC22_RS03880	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC22_RS03880	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC22_RS03890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_RS03895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_RS03905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_RS03910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_RS03915	COG2190	(PTS) system
FORC22_RS03920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC22_RS03925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_RS03935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC22_RS03940	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC22_RS03945	COG3115	cell septum assembly
FORC22_RS03950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC22_RS03975	COG0330	HflC and HflK could
FORC22_RS03980	COG3118	belongs to the thioredoxin family
FORC22_RS03985	COG0300	oxidoreductase activity
FORC22_RS03990	COG1090	epimerase
FORC22_RS04020	COG0622	Phosphoesterase
FORC22_RS04040	COG3710	Transcriptional regulator
FORC22_RS04045	COG0326	Molecular chaperone. Has ATPase activity
FORC22_RS04050	COG0563	adenylate kinase activity
FORC22_RS04055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC22_RS04060	COG3104	oligopeptide transport
FORC22_RS04065	COG0250	Participates in transcription elongation, termination and antitermination
FORC22_RS04070	COG0367	asparagine synthase
FORC22_RS04075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC22_RS04075	COG4651	solute:proton antiporter activity
FORC22_RS04080	COG1940	carbohydrate kinase activity
FORC22_RS04080	COG1846	Transcriptional regulator
FORC22_RS04085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC22_RS04090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC22_RS04090	COG1263	PTS System
FORC22_RS04095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC22_RS04100	COG0735	belongs to the Fur family
FORC22_RS04120	COG0596	Alpha beta hydrolase
FORC22_RS04125	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC22_RS04130	COG0033	Phosphoglucomutase
FORC22_RS04140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC22_RS04155	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC22_RS04160	COG1053	succinate dehydrogenase
FORC22_RS04165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC22_RS04170	COG0567	Dehydrogenase, E1 component
FORC22_RS04175	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC22_RS04180	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC22_RS04190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC22_RS04195	COG1121	(ABC) transporter
FORC22_RS04200	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC22_RS04205	COG4977	sequence-specific DNA binding
FORC22_RS04210	COG1918	ferrous iron import across plasma membrane
FORC22_RS04230	COG0018	arginyl-trna synthetase
FORC22_RS04235	COG3102	Protein conserved in bacteria
FORC22_RS04240	COG0788	formyltetrahydrofolate deformylase activity
FORC22_RS04245	COG1199	ATP-dependent helicase activity
FORC22_RS04250	COG1214	PFAM Peptidase M22, glycoprotease
FORC22_RS04265	COG2267	carboxylic ester hydrolase activity
FORC22_RS04270	COG0318	PFAM AMP-dependent synthetase and ligase
FORC22_RS04275	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC22_RS04280	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC22_RS04285	COG2894	cell division
FORC22_RS04290	COG0850	regulation of cytokinetic process
FORC22_RS04295	COG3100	YcgL domain-containing protein
FORC22_RS04300	COG2951	lytic endotransglycosylase activity
FORC22_RS04305	COG0583	DNA-binding transcription factor activity
FORC22_RS04310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC22_RS04315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC22_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_RS04345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC22_RS04370	COG2986	histidine ammonia-lyase
FORC22_RS04375	COG1216	Glycosyl transferase, family 2
FORC22_RS04380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC22_RS04395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC22_RS04400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC22_RS04435	COG1253	flavin adenine dinucleotide binding
FORC22_RS04440	COG0513	Belongs to the DEAD box helicase family
FORC22_RS04445	COG0569	domain protein
FORC22_RS04450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC22_RS04465	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FORC22_RS04470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC22_RS04475	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC22_RS04480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC22_RS04490	COG2204	response regulator
FORC22_RS04505	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC22_RS04515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC22_RS04520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC22_RS04525	COG0776	regulation of translation
FORC22_RS04530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC22_RS04535	COG1555	photosystem II stabilization
FORC22_RS04550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC22_RS04555	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC22_RS04560	COG0436	Aminotransferase
FORC22_RS04565	COG1169	isochorismate synthase
FORC22_RS04570	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC22_RS04575	COG0596	Alpha beta hydrolase
FORC22_RS04580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC22_RS04600	COG2855	membrane
FORC22_RS04605	COG0477	Major facilitator Superfamily
FORC22_RS04655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_RS04680	COG1522	sequence-specific DNA binding
FORC22_RS04690	COG1946	Acyl-CoA thioesterase
FORC22_RS04695	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC22_RS04710	COG2199	diguanylate cyclase activity
FORC22_RS04720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC22_RS04725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC22_RS04730	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC22_RS04735	COG0517	IMP dehydrogenase activity
FORC22_RS04735	COG0516	GMP reductase activity
FORC22_RS04760	COG0537	adenosine 5'-monophosphoramidase activity
FORC22_RS04785	COG3150	esterase
FORC22_RS04790	COG1252	NADH dehydrogenase
FORC22_RS04805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC22_RS04815	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC22_RS04820	COG1136	(ABC) transporter
FORC22_RS04825	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC22_RS04835	COG2333	competence protein COMEC
FORC22_RS04835	COG0658	competence protein
FORC22_RS04840	COG1132	(ABC) transporter
FORC22_RS04845	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC22_RS04855	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC22_RS04860	COG2719	SpoVR family
FORC22_RS04865	COG2718	Belongs to the UPF0229 family
FORC22_RS04870	COG2766	serine protein kinase
FORC22_RS04875	COG3013	Belongs to the UPF0304 family
FORC22_RS04885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC22_RS04895	COG1882	Formate acetyltransferase
FORC22_RS04935	COG0708	Exodeoxyribonuclease III
FORC22_RS04945	COG3923	Primosomal replication protein n
FORC22_RS04950	COG0730	response to heat
FORC22_RS04955	COG1199	ATP-dependent helicase activity
FORC22_RS04965	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC22_RS04970	COG1187	pseudouridine synthase activity
FORC22_RS04980	COG1278	Cold shock
FORC22_RS04985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC22_RS04990	COG0542	response to heat
FORC22_RS05000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC22_RS05005	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC22_RS05010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC22_RS05020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC22_RS05030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC22_RS05035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC22_RS05040	COG0297	glycogen (starch) synthase activity
FORC22_RS05060	COG3070	regulator of competence-specific genes
FORC22_RS05065	COG1609	Transcriptional regulator
FORC22_RS05070	COG3381	protein complex oligomerization
FORC22_RS05075	COG0745	RESPONSE REGULATOR receiver
FORC22_RS05080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC22_RS05085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC22_RS05090	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC22_RS05095	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC22_RS05100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC22_RS05115	COG4067	protein conserved in archaea
FORC22_RS05115	COG0189	ligase activity
FORC22_RS05120	COG0500	methyltransferase
FORC22_RS05125	COG4106	trans-aconitate 2-methyltransferase activity
FORC22_RS05130	COG1801	Protein of unknown function DUF72
FORC22_RS05135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC22_RS05140	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC22_RS05145	COG0840	transmembrane signaling receptor activity
FORC22_RS05150	COG0632	four-way junction helicase activity
FORC22_RS05155	COG2255	four-way junction helicase activity
FORC22_RS05160	COG1271	oxidase subunit
FORC22_RS05165	COG1294	oxidase, subunit
FORC22_RS05170	COG4890	Cyd operon protein YbgT
FORC22_RS05180	COG0824	Thioesterase
FORC22_RS05185	COG0811	peptide transport
FORC22_RS05200	COG0823	Involved in the tonB-independent uptake of proteins
FORC22_RS05205	COG2885	chlorophyll binding
FORC22_RS05210	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC22_RS05215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC22_RS05225	COG3766	membrane
FORC22_RS05235	COG0754	glutathionylspermidine amidase activity
FORC22_RS05245	COG5002	protein histidine kinase activity
FORC22_RS05245	COG0784	Response regulator, receiver
FORC22_RS05265	COG2801	Transposase and inactivated derivatives
FORC22_RS05270	COG2963	transposase activity
FORC22_RS05315	COG0582	viral genome integration into host DNA
FORC22_RS05405	COG2801	Transposase and inactivated derivatives
FORC22_RS05410	COG2963	transposase activity
FORC22_RS05430	COG0840	transmembrane signaling receptor activity
FORC22_RS05435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_RS05440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_RS05465	COG3568	Endonuclease Exonuclease Phosphatase
FORC22_RS05480	COG0583	DNA-binding transcription factor activity
FORC22_RS05490	COG0686	Belongs to the AlaDH PNT family
FORC22_RS05500	COG1674	ftsk spoiiie
FORC22_RS05505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC22_RS05510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC22_RS05515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC22_RS05530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC22_RS05535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC22_RS05540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC22_RS05545	COG0156	8-amino-7-oxononanoate synthase activity
FORC22_RS05555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC22_RS05560	COG0501	Belongs to the peptidase M48B family
FORC22_RS05570	COG0300	oxidoreductase activity
FORC22_RS05585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC22_RS05605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC22_RS05610	COG2915	High frequency lysogenization protein hflD homolog
FORC22_RS05615	COG0482	sulfurtransferase activity
FORC22_RS05625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC22_RS05635	COG1757	Na H antiporter
FORC22_RS05650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC22_RS05655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORC22_RS05660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC22_RS05665	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC22_RS05665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC22_RS05670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC22_RS05675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC22_RS05680	COG0107	imidazoleglycerol-phosphate synthase activity
FORC22_RS05685	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC22_RS05685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC22_RS05690	COG3012	SEC-C Motif Domain Protein
FORC22_RS05695	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC22_RS05700	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC22_RS05705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC22_RS05710	COG0215	cysteine-tRNA ligase activity
FORC22_RS05715	COG1435	thymidine kinase activity
FORC22_RS05720	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC22_RS05745	COG2116	formate transmembrane transporter activity
FORC22_RS05755	COG4459	periplasmic nitrate reductase
FORC22_RS05760	COG3005	denitrification pathway
FORC22_RS05765	COG0243	molybdopterin cofactor binding
FORC22_RS05780	COG1227	inorganic diphosphatase activity
FORC22_RS05790	COG4172	Belongs to the ABC transporter superfamily
FORC22_RS05800	COG4171	peptide transport system, permease
FORC22_RS05815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC22_RS05820	COG1842	Phage shock protein A
FORC22_RS05830	COG1983	PspC domain protein
FORC22_RS05835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_RS05850	COG2818	Glycosylase
FORC22_RS05855	COG5380	lipid catabolic process
FORC22_RS05860	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC22_RS05865	COG0626	cystathionine gamma-synthase activity
FORC22_RS05875	COG0733	neurotransmitter:sodium symporter activity
FORC22_RS05885	COG0564	pseudouridine synthase activity
FORC22_RS05895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC22_RS05900	COG1151	hydroxylamine reductase activity
FORC22_RS05905	COG3604	Transcriptional regulator
FORC22_RS05915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC22_RS05920	COG4136	ATPase activity
FORC22_RS05925	COG4135	transport system, permease component
FORC22_RS05930	COG4134	Bacterial extracellular solute-binding protein
FORC22_RS05935	COG0398	Pfam SNARE associated Golgi protein
FORC22_RS05945	COG0493	'glutamate synthase
FORC22_RS05970	COG3313	Fe-S protein
FORC22_RS05995	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC22_RS06015	COG1061	Type III restriction enzyme res subunit
FORC22_RS06020	COG1187	pseudouridine synthase activity
FORC22_RS06055	COG3005	denitrification pathway
FORC22_RS06060	COG0702	epimerase
FORC22_RS06065	COG0534	Mate efflux family protein
FORC22_RS06070	COG4181	ATPase activity
FORC22_RS06085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC22_RS06100	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC22_RS06105	COG3273	potassium ion transport
FORC22_RS06105	COG2985	domain, Protein
FORC22_RS06110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC22_RS06120	COG1737	Transcriptional regulator
FORC22_RS06125	COG0076	glutamate decarboxylase activity
FORC22_RS06135	COG2431	L-lysine efflux transmembrane transporter activity
FORC22_RS06150	COG3070	regulator of competence-specific genes
FORC22_RS06165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_RS06165	COG4191	Histidine kinase
FORC22_RS06175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC22_RS06180	COG3048	D-serine ammonia-lyase activity
FORC22_RS06185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC22_RS06190	COG4988	ABC transporter
FORC22_RS06195	COG0492	ferredoxin-NADP+ reductase activity
FORC22_RS06220	COG0471	metal ion transport
FORC22_RS06225	COG2949	membrane
FORC22_RS06230	COG0281	malic enzyme
FORC22_RS06235	COG1643	Atp-dependent helicase
FORC22_RS06240	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC22_RS06255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC22_RS06290	COG0247	lactate metabolic process
FORC22_RS06290	COG0277	FAD linked oxidase domain protein
FORC22_RS06305	COG2986	histidine ammonia-lyase
FORC22_RS06310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC22_RS06315	COG0010	Belongs to the arginase family
FORC22_RS06320	COG1228	amidohydrolase
FORC22_RS06325	COG2188	Transcriptional regulator
FORC22_RS06340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC22_RS06350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC22_RS06360	COG0393	Putative heavy-metal-binding
FORC22_RS06390	COG3706	GGDEF domain
FORC22_RS06395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC22_RS06400	COG0072	phenylalanine-tRNA ligase activity
FORC22_RS06400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC22_RS06410	COG0776	regulation of translation
FORC22_RS06420	COG0500	methyltransferase
FORC22_RS06425	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC22_RS06430	COG0295	cytidine deaminase activity
FORC22_RS06435	COG1346	cytolysis
FORC22_RS06440	COG1380	Effector of murein hydrolase LrgA
FORC22_RS06445	COG2925	Exonuclease
FORC22_RS06450	COG1823	symporter activity
FORC22_RS06455	COG0702	epimerase
FORC22_RS06460	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC22_RS06465	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC22_RS06485	COG2988	succinylglutamate desuccinylase activity
FORC22_RS06490	COG4139	cobalamin transport
FORC22_RS06495	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC22_RS06515	COG0583	DNA-binding transcription factor activity
FORC22_RS06535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC22_RS06540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC22_RS06545	COG3475	LICD family
FORC22_RS06550	COG1451	nucleotide metabolic process
FORC22_RS06555	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC22_RS06585	COG3938	Belongs to the proline racemase family
FORC22_RS06600	COG2423	ornithine cyclodeaminase activity
FORC22_RS06605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC22_RS06610	COG3842	ATPase activity
FORC22_RS06615	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC22_RS06620	COG1177	transmembrane transport
FORC22_RS06635	COG3291	Pkd domain containing protein
FORC22_RS06650	COG0444	Belongs to the ABC transporter superfamily
FORC22_RS06655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC22_RS06660	COG0601	transmembrane transport
FORC22_RS06670	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC22_RS06685	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC22_RS06695	COG0625	glutathione transferase activity
FORC22_RS06800	COG1278	Cold shock
FORC22_RS06805	COG0557	exoribonuclease II activity
FORC22_RS06850	COG1783	phage Terminase large subunit
FORC22_RS07050	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC22_RS07055	COG0583	DNA-binding transcription factor activity
FORC22_RS07090	COG0471	metal ion transport
FORC22_RS07095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_RS07095	COG4191	Histidine kinase
FORC22_RS07105	COG5001	Diguanylate cyclase
FORC22_RS07105	COG3300	MHYT domain
FORC22_RS07115	COG1280	lysine exporter protein (LysE YggA)
FORC22_RS07120	COG1328	CTP reductase activity
FORC22_RS07125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC22_RS07135	COG0861	Integral membrane protein TerC family
FORC22_RS07140	COG0739	heme binding
FORC22_RS07160	COG2885	chlorophyll binding
FORC22_RS07180	COG3501	Rhs element vgr protein
FORC22_RS07205	COG0515	serine threonine protein kinase
FORC22_RS07240	COG1522	sequence-specific DNA binding
FORC22_RS07335	COG0861	Integral membrane protein TerC family
FORC22_RS07345	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC22_RS07355	COG0814	amino acid
FORC22_RS07375	COG1132	(ABC) transporter
FORC22_RS07380	COG1132	(ABC) transporter
FORC22_RS07405	COG0443	Heat shock 70 kDa protein
FORC22_RS07410	COG0443	Heat shock 70 kDa protein
FORC22_RS07420	COG3706	GGDEF domain
FORC22_RS07450	COG0243	molybdopterin cofactor binding
FORC22_RS07455	COG0437	4 iron, 4 sulfur cluster binding
FORC22_RS07460	COG3302	dmso reductase anchor subunit
FORC22_RS07475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC22_RS07480	COG1643	Atp-dependent helicase
FORC22_RS07495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC22_RS07505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC22_RS07510	COG1215	transferase activity, transferring glycosyl groups
FORC22_RS07515	COG0438	transferase activity, transferring glycosyl groups
FORC22_RS07555	COG2204	response regulator
FORC22_RS07585	COG1793	dna ligase
FORC22_RS07595	COG0534	Mate efflux family protein
FORC22_RS07600	COG0307	riboflavin synthase, alpha
FORC22_RS07610	COG3001	Fructosamine kinase
FORC22_RS07615	COG2201	protein-glutamate methylesterase activity
FORC22_RS07620	COG3706	GGDEF domain
FORC22_RS07630	COG0791	NLP P60 protein
FORC22_RS07635	COG0840	transmembrane signaling receptor activity
FORC22_RS07670	COG3148	PFAM DTW domain containing protein
FORC22_RS07675	COG1940	carbohydrate kinase activity
FORC22_RS07685	COG0303	'Molybdopterin
FORC22_RS07690	COG0746	molybdenum cofactor guanylyltransferase activity
FORC22_RS07695	COG3842	ATPase activity
FORC22_RS07710	COG2204	response regulator
FORC22_RS07715	COG4191	Histidine kinase
FORC22_RS07720	COG0488	(ABC) transporter
FORC22_RS07725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC22_RS07745	COG3381	protein complex oligomerization
FORC22_RS07755	COG3383	formate dehydrogenase (NAD+) activity
FORC22_RS07755	COG0243	molybdopterin cofactor binding
FORC22_RS07760	COG0437	4 iron, 4 sulfur cluster binding
FORC22_RS07780	COG4282	regulation of fungal-type cell wall biogenesis
FORC22_RS07785	COG0004	ammonium transporteR
FORC22_RS07795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC22_RS07800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC22_RS07810	COG1177	transmembrane transport
FORC22_RS07820	COG3842	ATPase activity
FORC22_RS07840	COG0037	tRNA processing
FORC22_RS07845	COG0589	response to stress
FORC22_RS07850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC22_RS07865	COG2217	Heavy metal translocating P-type atpase
FORC22_RS07875	COG2010	Cytochrome c
FORC22_RS07890	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC22_RS07905	COG0784	Response regulator, receiver
FORC22_RS07905	COG2205	protein histidine kinase activity
FORC22_RS08060	COG4128	Pfam Zonular occludens toxin
FORC22_RS08100	COG3120	sequence-specific DNA binding
FORC22_RS08105	COG1067	ATP-dependent peptidase activity
FORC22_RS08110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC22_RS08125	COG0488	(ABC) transporter
FORC22_RS08135	COG0116	Belongs to the methyltransferase superfamily
FORC22_RS08135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC22_RS08145	COG0167	dihydroorotate dehydrogenase activity
FORC22_RS08160	COG0308	aminopeptidase N
FORC22_RS08175	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FORC22_RS08180	COG1956	GAF domain-containing protein
FORC22_RS08185	COG1132	(ABC) transporter
FORC22_RS08190	COG2995	paraquat-inducible protein a
FORC22_RS08195	COG3008	intermembrane lipid transfer
FORC22_RS08205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC22_RS08205	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FORC22_RS08225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC22_RS08230	COG1666	GTP binding
FORC22_RS08240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_RS08245	COG4597	amino acid ABC transporter
FORC22_RS08250	COG0765	amino acid transport
FORC22_RS08255	COG1126	abc transporter atp-binding protein
FORC22_RS08260	COG0670	Belongs to the BI1 family
FORC22_RS08270	COG2920	part of a sulfur-relay system
FORC22_RS08275	COG1254	Belongs to the acylphosphatase family
FORC22_RS08280	COG0840	transmembrane signaling receptor activity
FORC22_RS08285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC22_RS08325	COG3706	GGDEF domain
FORC22_RS08330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC22_RS08335	COG0602	queuosine metabolic process
FORC22_RS08340	COG0561	phosphatase activity
FORC22_RS08365	COG2828	Protein conserved in bacteria
FORC22_RS08375	COG0372	Belongs to the citrate synthase family
FORC22_RS08380	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC22_RS08410	COG0730	response to heat
FORC22_RS08430	COG0457	Tetratricopeptide repeat
FORC22_RS08500	COG4790	Type iii secretion
FORC22_RS08505	COG4794	Type iii secretion
FORC22_RS08510	COG4791	protein targeting
FORC22_RS08515	COG4792	protein secretion
FORC22_RS08525	COG1073	alpha beta
FORC22_RS08530	COG1073	alpha beta
FORC22_RS08560	COG3177	Filamentation induced by cAMP protein fic
FORC22_RS08580	COG4669	(LipO)protein
FORC22_RS08650	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_RS08655	COG3284	Transcriptional regulator
FORC22_RS08675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC22_RS08680	COG0363	glucosamine-6-phosphate deaminase activity
FORC22_RS08685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC22_RS08690	COG4565	transcriptional regulatory protein
FORC22_RS08695	COG3290	protein histidine kinase activity
FORC22_RS08710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_RS08725	COG1858	cytochrome C peroxidase
FORC22_RS08730	COG0527	aspartate kinase activity
FORC22_RS08735	COG0662	Cupin 2, conserved barrel domain protein
FORC22_RS08740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC22_RS08745	COG0456	acetyltransferase
FORC22_RS08750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC22_RS08770	COG4176	ABC-type proline glycine betaine transport system permease component
FORC22_RS08775	COG2113	Glycine betaine
FORC22_RS08795	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_RS08805	COG0745	RESPONSE REGULATOR receiver
FORC22_RS08810	COG0642	Histidine kinase
FORC22_RS08815	COG1368	sulfuric ester hydrolase activity
FORC22_RS08840	COG2801	Transposase and inactivated derivatives
FORC22_RS08845	COG2963	transposase activity
FORC22_RS08850	COG1115	amino acid carrier protein
FORC22_RS08860	COG1280	lysine exporter protein (LysE YggA)
FORC22_RS08865	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC22_RS08870	COG1560	Kdo2-lipid A biosynthetic process
FORC22_RS08875	COG0531	amino acid
FORC22_RS08885	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC22_RS08890	COG3063	Type IV pilus biogenesis stability protein PilW
FORC22_RS08920	COG0110	maltose O-acetyltransferase activity
FORC22_RS08940	COG2315	Protein conserved in bacteria
FORC22_RS08945	COG1846	Transcriptional regulator
FORC22_RS08960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC22_RS08975	COG2771	luxR family
FORC22_RS08975	COG2200	EAL domain
FORC22_RS08980	COG1227	inorganic diphosphatase activity
FORC22_RS08985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC22_RS08990	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_RS08995	COG2957	Belongs to the agmatine deiminase family
FORC22_RS09005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC22_RS09010	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_RS09015	COG1396	sequence-specific DNA binding
FORC22_RS09015	COG1917	Cupin 2, conserved barrel domain protein
FORC22_RS09020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FORC22_RS09025	COG0174	glutamine synthetase
FORC22_RS09030	COG1757	Na H antiporter
FORC22_RS09215	COG0494	nUDIX hydrolase
FORC22_RS09235	COG3422	double-strand break repair
FORC22_RS09370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC22_RS09370	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC22_RS09560	COG2801	Transposase and inactivated derivatives
FORC22_RS09565	COG2963	transposase activity
FORC22_RS09610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC22_RS09610	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC22_RS09620	COG0456	acetyltransferase
FORC22_RS09705	COG4628	conserved protein (DUF2132)
FORC22_RS09715	COG0494	nUDIX hydrolase
FORC22_RS09765	COG0346	lactoylglutathione lyase activity
FORC22_RS09810	COG0346	lactoylglutathione lyase activity
FORC22_RS09825	COG2963	transposase activity
FORC22_RS09830	COG2801	Transposase and inactivated derivatives
FORC22_RS09885	COG0456	acetyltransferase
FORC22_RS10040	COG1335	isochorismatase
FORC22_RS10050	COG2963	transposase activity
FORC22_RS10055	COG2801	Transposase and inactivated derivatives
FORC22_RS10195	COG0456	acetyltransferase
FORC22_RS10275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC22_RS10285	COG3768	UPF0283 membrane protein
FORC22_RS10290	COG3106	COG3106 Predicted ATPase
FORC22_RS10310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC22_RS10315	COG0784	Response regulator, receiver
FORC22_RS10315	COG2205	protein histidine kinase activity
FORC22_RS10325	COG0494	nUDIX hydrolase
FORC22_RS10330	COG0814	amino acid
FORC22_RS10335	COG1760	l-serine dehydratase
FORC22_RS10340	COG2200	EAL domain
FORC22_RS10350	COG0720	synthase
FORC22_RS10360	COG0017	Asparaginyl-tRNA synthetase
FORC22_RS10370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC22_RS10385	COG1448	Aminotransferase
FORC22_RS10410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC22_RS10415	COG1846	Transcriptional regulator
FORC22_RS10440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC22_RS10455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC22_RS10460	COG3108	Peptidase M15
FORC22_RS10465	COG2989	Protein conserved in bacteria
FORC22_RS10490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC22_RS10500	COG3088	subunit of a heme lyase
FORC22_RS10500	COG4235	cytochrome complex assembly
FORC22_RS10515	COG3301	Polysulphide reductase, NrfD
FORC22_RS10530	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC22_RS10550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC22_RS10560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC22_RS10565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC22_RS10590	COG0019	diaminopimelate decarboxylase activity
FORC22_RS10635	COG0322	excinuclease ABC activity
FORC22_RS10640	COG2197	response regulator
FORC22_RS10645	COG0417	DNA replication proofreading
FORC22_RS10655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC22_RS10660	COG3099	Belongs to the UPF0263 family
FORC22_RS10665	COG1187	pseudouridine synthase activity
FORC22_RS10675	COG0009	L-threonylcarbamoyladenylate synthase
FORC22_RS10680	COG0613	PHP domain protein
FORC22_RS10690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC22_RS10695	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC22_RS10700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC22_RS10705	COG0135	phosphoribosylanthranilate isomerase activity
FORC22_RS10705	COG0134	indole-3-glycerol-phosphate synthase activity
FORC22_RS10710	COG0133	tryptophan synthase activity
FORC22_RS10715	COG0159	tryptophan synthase activity
FORC22_RS10720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC22_RS10725	COG0318	PFAM AMP-dependent synthetase and ligase
FORC22_RS10730	COG1301	dicarboxylic acid transport
FORC22_RS10750	COG2917	probably involved in intracellular septation
FORC22_RS10760	COG2350	Protein conserved in bacteria
FORC22_RS10770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC22_RS10775	COG0583	DNA-binding transcription factor activity
FORC22_RS10790	COG2203	Gaf domain
FORC22_RS10790	COG4251	negative regulation of phosphorylation
FORC22_RS10790	COG3706	GGDEF domain
FORC22_RS10790	COG5001	Diguanylate cyclase
FORC22_RS10795	COG1032	radical SAM domain protein
FORC22_RS10800	COG0840	transmembrane signaling receptor activity
FORC22_RS10805	COG0745	RESPONSE REGULATOR receiver
FORC22_RS10810	COG3850	Histidine kinase
FORC22_RS10810	COG5002	protein histidine kinase activity
FORC22_RS10860	COG1335	isochorismatase
FORC22_RS10865	COG0577	efflux transmembrane transporter activity
FORC22_RS10865	COG1136	(ABC) transporter
FORC22_RS10870	COG0577	efflux transmembrane transporter activity
FORC22_RS10870	COG1136	(ABC) transporter
FORC22_RS10875	COG1136	(ABC) transporter
FORC22_RS10875	COG0577	efflux transmembrane transporter activity
FORC22_RS10885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_RS10915	COG3118	belongs to the thioredoxin family
FORC22_RS10920	COG4232	protein-disulfide reductase activity
FORC22_RS10960	COG2863	cytochrome
FORC22_RS10965	COG3258	Cytochrome c
FORC22_RS10970	COG2995	paraquat-inducible protein a
FORC22_RS10975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC22_RS10975	COG3008	intermembrane lipid transfer
FORC22_RS10985	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC22_RS11010	COG4166	transmembrane transport
FORC22_RS11015	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC22_RS11020	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC22_RS11025	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC22_RS11035	COG0539	negative regulation of cytoplasmic translation
FORC22_RS11040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC22_RS11045	COG0616	signal peptide processing
FORC22_RS11050	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_RS11065	COG0587	DNA-directed DNA polymerase activity
FORC22_RS11070	COG0835	chemotaxis
FORC22_RS11070	COG0784	Response regulator, receiver
FORC22_RS11075	COG1940	carbohydrate kinase activity
FORC22_RS11080	COG0469	pyruvate kinase activity
FORC22_RS11085	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC22_RS11095	COG0733	neurotransmitter:sodium symporter activity
FORC22_RS11105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC22_RS11105	COG1263	PTS System
FORC22_RS11110	COG0084	hydrolase, TatD family'
FORC22_RS11120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC22_RS11125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC22_RS11155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC22_RS11160	COG0416	fatty acid biosynthetic process
FORC22_RS11170	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC22_RS11175	COG0424	maF-like protein
FORC22_RS11180	COG0564	pseudouridine synthase activity
FORC22_RS11190	COG1530	ribonuclease E activity
FORC22_RS11195	COG0659	secondary active sulfate transmembrane transporter activity
FORC22_RS11200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC22_RS11205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC22_RS11215	COG0572	uridine kinase
FORC22_RS11220	COG0489	protein tyrosine kinase activity
FORC22_RS11225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC22_RS11225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC22_RS11235	COG2186	Transcriptional regulator
FORC22_RS11240	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC22_RS11245	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC22_RS11250	COG3012	SEC-C Motif Domain Protein
FORC22_RS11250	COG3318	Belongs to the UPF0149 family
FORC22_RS11255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC22_RS11265	COG0366	Alpha amylase catalytic
FORC22_RS11270	COG1122	ATPase activity
FORC22_RS11275	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC22_RS11285	COG3092	negative regulation of chromosome organization
FORC22_RS11290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC22_RS11295	COG0280	phosphate acetyltransferase
FORC22_RS11295	COG0857	belongs to the CobB CobQ family
FORC22_RS11300	COG3174	membrane
FORC22_RS11310	COG0435	Glutathione S-transferase
FORC22_RS11320	COG0444	Belongs to the ABC transporter superfamily
FORC22_RS11325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC22_RS11330	COG0601	transmembrane transport
FORC22_RS11340	COG0314	molybdopterin synthase activity
FORC22_RS11345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC22_RS11350	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC22_RS11355	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC22_RS11360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC22_RS11365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC22_RS11370	COG2198	Histidine kinase
FORC22_RS11375	COG2204	response regulator
FORC22_RS11380	COG0556	nucleotide-excision repair
FORC22_RS11390	COG4657	Part of a membrane complex involved in electron transport
FORC22_RS11395	COG2878	Part of a membrane complex involved in electron transport
FORC22_RS11400	COG4656	Part of a membrane complex involved in electron transport
FORC22_RS11405	COG4658	electron transport chain
FORC22_RS11410	COG4659	FMN binding
FORC22_RS11415	COG4660	Part of a membrane complex involved in electron transport
FORC22_RS11420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC22_RS11425	COG0346	lactoylglutathione lyase activity
FORC22_RS11435	COG2885	chlorophyll binding
FORC22_RS11440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC22_RS11445	COG2056	Na+-H+ antiporter family
FORC22_RS11455	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC22_RS11475	COG1454	alcohol dehydrogenase
FORC22_RS11475	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_RS11480	COG2095	MarC family integral membrane protein
FORC22_RS11485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC22_RS11490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC22_RS11495	COG1757	Na H antiporter
FORC22_RS11510	COG3081	Nucleoid-associated protein
FORC22_RS11515	COG3082	Protein of unknown function (DUF1414)
FORC22_RS11520	COG3083	sulfuric ester hydrolase activity
FORC22_RS11530	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC22_RS11545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC22_RS11550	COG0778	Nitroreductase
FORC22_RS11555	COG1902	pentaerythritol trinitrate reductase activity
FORC22_RS11555	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC22_RS11560	COG0616	signal peptide processing
FORC22_RS11565	COG0252	asparaginase activity
FORC22_RS11570	COG3139	Protein of unknown function (DUF1315)
FORC22_RS11580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC22_RS11585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC22_RS11600	COG2226	methyltransferase
FORC22_RS11615	COG1785	Belongs to the alkaline phosphatase family
FORC22_RS11625	COG0346	lactoylglutathione lyase activity
FORC22_RS11630	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC22_RS11635	COG0668	transmembrane transport
FORC22_RS11640	COG2983	Belongs to the UPF0260 family
FORC22_RS11645	COG2261	transglycosylase associated protein
FORC22_RS11660	COG3681	Belongs to the UPF0597 family
FORC22_RS11665	COG0251	oxidation-reduction process
FORC22_RS11670	COG0814	amino acid
FORC22_RS11675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC22_RS11680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC22_RS11685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC22_RS11695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC22_RS11700	COG2832	Protein of unknown function (DUF454)
FORC22_RS11705	COG0745	RESPONSE REGULATOR receiver
FORC22_RS11710	COG0583	DNA-binding transcription factor activity
FORC22_RS11715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC22_RS11720	COG1286	toxin biosynthetic process
FORC22_RS11725	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC22_RS11730	COG0285	dihydrofolate synthase activity
FORC22_RS11735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC22_RS11745	COG0101	tRNA pseudouridine synthase activity
FORC22_RS11755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC22_RS11760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC22_RS11770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC22_RS11775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC22_RS11775	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC22_RS11780	COG0431	NADPH-dependent FMN reductase
FORC22_RS11790	COG3101	peptidyl-lysine hydroxylation
FORC22_RS11795	COG2860	membrane
FORC22_RS11800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC22_RS11805	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC22_RS11810	COG2840	Smr protein MutS2
FORC22_RS11815	COG2062	phosphohistidine phosphatase, SixA
FORC22_RS11830	COG1024	Enoyl-CoA hydratase
FORC22_RS11830	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC22_RS11835	COG0183	Belongs to the thiolase family
FORC22_RS11855	COG2067	long-chain fatty acid transport protein
FORC22_RS11865	COG2853	Lipoprotein
FORC22_RS11880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC22_RS11885	COG1138	Cytochrome C-type biogenesis protein
FORC22_RS11890	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC22_RS11895	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC22_RS11900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC22_RS11905	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC22_RS11910	COG4133	protoheme IX ABC transporter activity
FORC22_RS11920	COG0835	chemotaxis
FORC22_RS11930	COG1192	Involved in chromosome partitioning
FORC22_RS11935	COG2201	protein-glutamate methylesterase activity
FORC22_RS11940	COG0784	Response regulator, receiver
FORC22_RS11940	COG2198	Histidine kinase
FORC22_RS11940	COG0643	Histidine kinase
FORC22_RS11945	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC22_RS11980	COG1684	flagellar biosynthetic protein fliR
FORC22_RS11985	COG1987	bacterial-type flagellum assembly
FORC22_RS12035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC22_RS12045	COG1677	Flagellar hook-basal body complex protein FliE
FORC22_RS12065	COG1516	flagellar protein fliS
FORC22_RS12075	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC22_RS12080	COG1334	flagellar protein FlaG
FORC22_RS12085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_RS12090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_RS12100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_RS12105	COG2837	iron assimilation
FORC22_RS12135	COG1393	Belongs to the ArsC family
FORC22_RS12140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC22_RS12155	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FORC22_RS12160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC22_RS12165	COG2716	regulation of RNA biosynthetic process
FORC22_RS12170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC22_RS12185	COG4783	chaperone-mediated protein folding
FORC22_RS12190	COG1393	Belongs to the ArsC family
FORC22_RS12210	COG2233	PERMEase
FORC22_RS12215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC22_RS12220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC22_RS12225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC22_RS12230	COG0121	glutamine amidotransferase
FORC22_RS12235	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC22_RS12240	COG1960	acyl-CoA dehydrogenase activity
FORC22_RS12250	COG0456	acetyltransferase
FORC22_RS12270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC22_RS12275	COG0328	RNA-DNA hybrid ribonuclease activity
FORC22_RS12280	COG2226	methyltransferase
FORC22_RS12285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC22_RS12290	COG1388	LysM domain
FORC22_RS12290	COG0741	lytic transglycosylase activity
FORC22_RS12300	COG3021	interspecies interaction between organisms
FORC22_RS12305	COG0347	Belongs to the P(II) protein family
FORC22_RS12315	COG0037	tRNA processing
FORC22_RS12320	COG0825	malonyl-CoA metabolic process
FORC22_RS12325	COG0587	DNA-directed DNA polymerase activity
FORC22_RS12335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC22_RS12340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC22_RS12345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC22_RS12350	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC22_RS12360	COG0750	zinc metalloprotease
FORC22_RS12365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC22_RS12370	COG0575	Belongs to the CDS family
FORC22_RS12375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC22_RS12380	COG0233	cytoplasmic translational termination
FORC22_RS12385	COG0528	UMP kinase activity
FORC22_RS12390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC22_RS12395	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC22_RS12400	COG0024	Methionine aminopeptidase
FORC22_RS12405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC22_RS12415	COG0564	pseudouridine synthase activity
FORC22_RS12420	COG3098	single-species biofilm formation
FORC22_RS12445	COG1671	Belongs to the UPF0178 family
FORC22_RS12450	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC22_RS12460	COG0254	rRNA binding
FORC22_RS12465	COG1720	tRNA m6t6A37 methyltransferase activity
FORC22_RS12470	COG0442	prolyl-tRNA aminoacylation
FORC22_RS12490	COG0733	neurotransmitter:sodium symporter activity
FORC22_RS12505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC22_RS12510	COG0514	ATP-dependent DNA helicase (RecQ)
FORC22_RS12515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC22_RS12530	COG1477	protein flavinylation
FORC22_RS12535	COG2871	sodium ion transport
FORC22_RS12540	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC22_RS12545	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC22_RS12550	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC22_RS12555	COG1805	sodium ion transport
FORC22_RS12560	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC22_RS12570	COG0271	Belongs to the BolA IbaG family
FORC22_RS12575	COG2813	Specifically methylates the guanine in position
FORC22_RS12580	COG3056	Lipoprotein
FORC22_RS12590	COG2211	Major facilitator Superfamily
FORC22_RS12600	COG1595	DNA-templated transcription, initiation
FORC22_RS12625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC22_RS12630	COG0693	protein deglycase activity
FORC22_RS12635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC22_RS12640	COG3706	GGDEF domain
FORC22_RS12645	COG2166	iron-sulfur cluster assembly
FORC22_RS12650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC22_RS12655	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC22_RS12665	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC22_RS12665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC22_RS12675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC22_RS12680	COG1074	ATP-dependent DNA helicase activity
FORC22_RS12690	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC22_RS12710	COG3141	response to X-ray
FORC22_RS12715	COG2171	N-acyltransferase activity
FORC22_RS12720	COG0584	glycerophosphoryl diester phosphodiesterase
FORC22_RS12725	COG2271	Major facilitator Superfamily
FORC22_RS12730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC22_RS12735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC22_RS12740	COG1349	DNA-binding transcription factor activity
FORC22_RS12745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC22_RS12750	COG0598	Magnesium transport protein CorA
FORC22_RS12765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC22_RS12770	COG1609	Transcriptional regulator
FORC22_RS12775	COG2176	DNA-directed DNA polymerase activity
FORC22_RS12790	COG2017	converts alpha-aldose to the beta-anomer
FORC22_RS12795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC22_RS12805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC22_RS12810	COG1609	Transcriptional regulator
FORC22_RS12815	COG3250	beta-galactosidase activity
FORC22_RS12820	COG2731	YhcH YjgK YiaL family protein
FORC22_RS12825	COG0531	amino acid
FORC22_RS12830	COG0583	DNA-binding transcription factor activity
FORC22_RS12890	COG4964	Belongs to the GSP D family
FORC22_RS12910	COG2169	Transcriptional regulator
FORC22_RS12915	COG1022	Amp-dependent synthetase and ligase
FORC22_RS12925	COG0583	DNA-binding transcription factor activity
FORC22_RS12930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC22_RS12935	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC22_RS12945	COG0560	Phosphoserine phosphatase
FORC22_RS12955	COG0813	purine-nucleoside phosphorylase activity
FORC22_RS12960	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC22_RS12965	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC22_RS12970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC22_RS12975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC22_RS12980	COG0084	hydrolase, TatD family'
FORC22_RS12990	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC22_RS13010	COG3153	acetyltransferase
FORC22_RS13015	COG3154	lipid carrier protein
FORC22_RS13030	COG0826	peptidase U32
FORC22_RS13035	COG0826	peptidase U32
FORC22_RS13040	COG0534	Mate efflux family protein
FORC22_RS13055	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC22_RS13060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC22_RS13065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC22_RS13070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC22_RS13075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC22_RS13080	COG0195	Participates in both transcription termination and antitermination
FORC22_RS13085	COG0779	Required for maturation of 30S ribosomal subunits
FORC22_RS13100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC22_RS13110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC22_RS13115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC22_RS13120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC22_RS13125	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC22_RS13130	COG1534	Rna-binding protein
FORC22_RS13135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC22_RS13140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC22_RS13145	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC22_RS13155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC22_RS13160	COG0739	heme binding
FORC22_RS13165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_RS13175	COG0316	Belongs to the HesB IscA family
FORC22_RS13180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC22_RS13185	COG0628	permease
FORC22_RS13190	COG2813	Specifically methylates the guanine in position
FORC22_RS13200	COG2198	Histidine kinase
FORC22_RS13200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_RS13200	COG0784	Response regulator, receiver
FORC22_RS13200	COG2205	protein histidine kinase activity
FORC22_RS13205	COG0747	negative chemotaxis
FORC22_RS13215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC22_RS13220	COG0444	Belongs to the ABC transporter superfamily
FORC22_RS13225	COG4608	Belongs to the ABC transporter superfamily
FORC22_RS13235	COG2971	BadF BadG BcrA BcrD
FORC22_RS13250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC22_RS13255	COG3842	ATPase activity
FORC22_RS13265	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC22_RS13270	COG0004	ammonium transporteR
FORC22_RS13280	COG3112	Uncharacterised protein family (UPF0231)
FORC22_RS13285	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC22_RS13290	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC22_RS13295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC22_RS13300	COG1643	Atp-dependent helicase
FORC22_RS13305	COG1489	DNA binding
FORC22_RS13315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC22_RS13325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC22_RS13330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC22_RS13335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC22_RS13340	COG1560	Kdo2-lipid A biosynthetic process
FORC22_RS13350	COG0842	Transport permease protein
FORC22_RS13355	COG1131	(ABC) transporter
FORC22_RS13360	COG0659	secondary active sulfate transmembrane transporter activity
FORC22_RS13365	COG0288	reversible hydration of carbon dioxide
FORC22_RS13380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC22_RS13385	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC22_RS13390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC22_RS13395	COG2186	Transcriptional regulator
FORC22_RS13405	COG0157	Belongs to the NadC ModD family
FORC22_RS13410	COG4969	Belongs to the N-Me-Phe pilin family
FORC22_RS13415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC22_RS13420	COG1459	type II secretion system
FORC22_RS13430	COG0237	dephospho-CoA kinase activity
FORC22_RS13435	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC22_RS13440	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC22_RS13445	COG0335	large ribosomal subunit rRNA binding
FORC22_RS13450	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC22_RS13455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC22_RS13460	COG0228	four-way junction DNA binding
FORC22_RS13465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC22_RS13470	COG4137	Cytochrome C assembly protein
FORC22_RS13475	COG4536	flavin adenine dinucleotide binding
FORC22_RS13480	COG1854	S-ribosylhomocysteine lyase activity
FORC22_RS13490	COG2918	glutathione biosynthetic process
FORC22_RS13495	COG0612	Peptidase, M16
FORC22_RS13500	COG1238	metal cluster binding
FORC22_RS13510	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC22_RS13515	COG0511	ligase activity, forming carbon-carbon bonds
FORC22_RS13515	COG5016	pyruvate
FORC22_RS13520	COG3630	sodium ion export across plasma membrane
FORC22_RS13580	COG0527	aspartate kinase activity
FORC22_RS13585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC22_RS13590	COG2137	regulation of response to DNA damage stimulus
FORC22_RS13595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC22_RS13600	COG1546	Belongs to the CinA family
FORC22_RS13605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC22_RS13610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC22_RS13620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC22_RS13625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC22_RS13630	COG0585	pseudouridine synthase activity
FORC22_RS13635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC22_RS13640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC22_RS13645	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC22_RS13650	COG0148	phosphopyruvate hydratase activity
FORC22_RS13655	COG0504	CTP synthase activity
FORC22_RS13660	COG3956	TIGRFAM MazG family protein
FORC22_RS13665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC22_RS13670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC22_RS13685	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC22_RS13690	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC22_RS13695	COG1381	Involved in DNA repair and RecF pathway recombination
FORC22_RS13705	COG0571	ribonuclease III activity
FORC22_RS13715	COG0481	GTPase activity
FORC22_RS13720	COG3086	response to oxidative stress
FORC22_RS13730	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC22_RS13735	COG1595	DNA-templated transcription, initiation
FORC22_RS13740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC22_RS13750	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FORC22_RS13755	COG0354	folic acid binding
FORC22_RS13770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC22_RS13775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC22_RS13780	COG3079	Belongs to the UPF0149 family
FORC22_RS13785	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC22_RS13795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC22_RS13800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC22_RS13805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC22_RS13815	COG0583	DNA-binding transcription factor activity
FORC22_RS13825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC22_RS13830	COG0668	transmembrane transport
FORC22_RS13835	COG0191	fructose-bisphosphate aldolase activity
FORC22_RS13840	COG0126	phosphoglycerate kinase activity
FORC22_RS13845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC22_RS13850	COG4771	TonB-dependent receptor
FORC22_RS13855	COG0583	DNA-binding transcription factor activity
FORC22_RS13860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC22_RS13870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC22_RS13880	COG3091	SprT-like family
FORC22_RS13885	COG2356	endonuclease I
FORC22_RS13890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC22_RS13895	COG0189	ligase activity
FORC22_RS13900	COG1678	Uncharacterized ACR, COG1678
FORC22_RS13905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC22_RS13920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC22_RS13925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC22_RS13930	COG0762	integral membrane protein
FORC22_RS13935	COG1872	DUF167
FORC22_RS13945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC22_RS13950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC22_RS13955	COG2066	Belongs to the glutaminase family
FORC22_RS13965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC22_RS13975	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC22_RS13980	COG0741	lytic transglycosylase activity
FORC22_RS14020	COG0840	transmembrane signaling receptor activity
FORC22_RS14050	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_RS14095	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC22_RS14105	COG3394	polysaccharide catabolic process
FORC22_RS14110	COG1486	melibiose metabolic process
FORC22_RS14115	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC22_RS14120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC22_RS14130	COG0726	polysaccharide deacetylase
FORC22_RS14140	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_RS14155	COG0795	lipopolysaccharide-transporting ATPase activity
FORC22_RS14160	COG0795	lipopolysaccharide-transporting ATPase activity
FORC22_RS14165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC22_RS14170	COG2927	DNA polymerase III (CHI subunit)
FORC22_RS14175	COG0525	valine-tRNA ligase activity
FORC22_RS14200	COG2235	arginine
FORC22_RS14205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FORC22_RS14215	COG0540	Belongs to the ATCase OTCase family
FORC22_RS14220	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC22_RS14225	COG0251	oxidation-reduction process
FORC22_RS14230	COG0204	Acyl-transferase
FORC22_RS14235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC22_RS14240	COG5007	Belongs to the BolA IbaG family
FORC22_RS14250	COG2854	intermembrane phospholipid transfer
FORC22_RS14255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC22_RS14260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC22_RS14265	COG1127	ABC transporter
FORC22_RS14275	COG0517	IMP dehydrogenase activity
FORC22_RS14275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC22_RS14285	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC22_RS14290	COG1137	ATPase activity
FORC22_RS14300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC22_RS14305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_RS14310	COG1660	Displays ATPase and GTPase activities
FORC22_RS14315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_RS14320	COG2239	Acts as a magnesium transporter
FORC22_RS14325	COG0312	modulator of DNA gyrase
FORC22_RS14330	COG3028	Belongs to the UPF0307 family
FORC22_RS14335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC22_RS14340	COG0564	pseudouridine synthase activity
FORC22_RS14350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC22_RS14355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC22_RS14360	COG0312	modulator of DNA gyrase
FORC22_RS14365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC22_RS14370	COG3164	Protein of unknown function
FORC22_RS14380	COG0424	maF-like protein
FORC22_RS14385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC22_RS14390	COG1792	Involved in formation and maintenance of cell shape
FORC22_RS14395	COG1077	Cell shape determining protein MreB Mrl
FORC22_RS14430	COG2165	general secretion pathway protein
FORC22_RS14440	COG1459	type II secretion system
FORC22_RS14445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC22_RS14455	COG3267	Type II secretory pathway component ExeA
FORC22_RS14455	COG3409	Peptidoglycan-binding domain 1 protein
FORC22_RS14480	COG2199	diguanylate cyclase activity
FORC22_RS14480	COG2200	EAL domain
FORC22_RS14485	COG0629	single-stranded DNA binding
FORC22_RS14500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC22_RS14510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC22_RS14520	COG0527	aspartate kinase activity
FORC22_RS14525	COG1410	methionine synthase
FORC22_RS14525	COG0646	methionine synthase
FORC22_RS14600	COG0175	sulfate reduction
FORC22_RS14605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC22_RS14610	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC22_RS14630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC22_RS14635	COG0735	belongs to the Fur family
FORC22_RS14645	COG0166	Belongs to the GPI family
FORC22_RS14650	COG0432	Pfam Uncharacterised protein family UPF0047
FORC22_RS14670	COG0359	binds to the 23S rRNA
FORC22_RS14680	COG2965	DNA replication, synthesis of RNA primer
FORC22_RS14685	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC22_RS14690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC22_RS14695	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC22_RS14705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC22_RS14710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC22_RS14740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC22_RS14750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC22_RS14750	COG0678	peroxiredoxin activity
FORC22_RS14760	COG0165	Argininosuccinate lyase
FORC22_RS14760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC22_RS14765	COG0137	argininosuccinate synthase activity
FORC22_RS14770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC22_RS14775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORC22_RS14780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC22_RS14785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC22_RS14795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC22_RS14800	COG0460	homoserine dehydrogenase
FORC22_RS14800	COG0527	aspartate kinase activity
FORC22_RS14805	COG0626	cystathionine gamma-synthase activity
FORC22_RS14815	COG0281	malic enzyme
FORC22_RS14825	COG2906	2 iron, 2 sulfur cluster binding
FORC22_RS14830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC22_RS14835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC22_RS14840	COG0049	tRNA binding
FORC22_RS14850	COG2168	tRNA wobble position uridine thiolation
FORC22_RS14855	COG2923	Belongs to the DsrF TusC family
FORC22_RS14860	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC22_RS14865	COG2964	Protein conserved in bacteria
FORC22_RS14870	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC22_RS14880	COG2900	Belongs to the SlyX family
FORC22_RS14885	COG1446	asparaginase
FORC22_RS14890	COG1047	Peptidyl-prolyl cis-trans
FORC22_RS14905	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC22_RS14910	COG0488	(ABC) transporter
FORC22_RS14920	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC22_RS14925	COG3089	Belongs to the UPF0270 family
FORC22_RS14930	COG3954	Phosphoribulokinase
FORC22_RS14935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC22_RS14945	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_RS14955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC22_RS14960	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC22_RS14975	COG0180	Tryptophanyl-tRNA synthetase
FORC22_RS14980	COG0546	phosphoglycolate phosphatase activity
FORC22_RS14985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC22_RS14990	COG0557	exoribonuclease II activity
FORC22_RS14995	COG1959	2 iron, 2 sulfur cluster binding
FORC22_RS15000	COG1017	nitric oxide dioxygenase activity
FORC22_RS15000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC22_RS15005	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC22_RS15010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC22_RS15015	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC22_RS15020	COG0330	HflC and HflK could
FORC22_RS15025	COG0330	HflC and HflK could
FORC22_RS15030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC22_RS15040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC22_RS15045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC22_RS15055	COG0802	atpase or kinase
FORC22_RS15060	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC22_RS15130	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC22_RS15135	COG1162	GTPase activity
FORC22_RS15140	COG0688	phosphatidylethanolamine metabolic process
FORC22_RS15145	COG0471	metal ion transport
FORC22_RS15150	COG0840	transmembrane signaling receptor activity
FORC22_RS15160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC22_RS15165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC22_RS15170	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC22_RS15175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC22_RS15180	COG1045	serine acetyltransferase
FORC22_RS15185	COG4942	peptidase
FORC22_RS15205	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC22_RS15210	COG1053	succinate dehydrogenase
FORC22_RS15215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC22_RS15220	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC22_RS15225	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC22_RS15235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC22_RS15240	COG1509	lysine 2,3-aminomutase activity
FORC22_RS15245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC22_RS15260	COG0459	protein refolding
FORC22_RS15270	COG0534	Mate efflux family protein
FORC22_RS15275	COG0205	6-phosphofructokinase activity
FORC22_RS15285	COG3678	ATP-independent chaperone mediated protein folding
FORC22_RS15290	COG0745	RESPONSE REGULATOR receiver
FORC22_RS15295	COG2205	protein histidine kinase activity
FORC22_RS15305	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC22_RS15310	COG3030	protein affecting phage T7 exclusion by the F plasmid
FORC22_RS15315	COG1027	Aspartate ammonia-lyase
FORC22_RS15320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC22_RS15325	COG4232	protein-disulfide reductase activity
FORC22_RS15335	COG3263	regulation of cellular component size
FORC22_RS15345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC22_RS15365	COG0784	Response regulator, receiver
FORC22_RS15365	COG2198	Histidine kinase
FORC22_RS15365	COG2205	protein histidine kinase activity
FORC22_RS15370	COG2814	Major facilitator Superfamily
FORC22_RS15385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC22_RS15390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC22_RS15395	COG0511	ligase activity, forming carbon-carbon bonds
FORC22_RS15400	COG0439	Biotin carboxylase
FORC22_RS15405	COG2264	protein methyltransferase activity
FORC22_RS15410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC22_RS15415	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC22_RS15425	COG0488	(ABC) transporter
FORC22_RS15430	COG3706	GGDEF domain
FORC22_RS15510	COG1982	Orn Lys Arg decarboxylase major
FORC22_RS15515	COG0531	amino acid
FORC22_RS15530	COG3710	Transcriptional regulator
FORC22_RS15535	COG0789	Transcriptional regulator
FORC22_RS15540	COG0138	bifunctional purine biosynthesis protein purh
FORC22_RS15545	COG0151	Belongs to the GarS family
FORC22_RS15560	COG1253	flavin adenine dinucleotide binding
FORC22_RS15575	COG1573	uracil-dna glycosylase
FORC22_RS15580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC22_RS15595	COG2816	NAD+ diphosphatase activity
FORC22_RS15600	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC22_RS15605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC22_RS15610	COG0085	RNA polymerase activity
FORC22_RS15615	COG0222	ribosome binding
FORC22_RS15620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC22_RS15625	COG0081	regulation of translation
FORC22_RS15630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC22_RS15635	COG0250	Participates in transcription elongation, termination and antitermination
FORC22_RS15640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC22_RS15645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC22_RS15680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC22_RS15690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC22_RS15745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC22_RS15755	COG4206	TonB-dependent receptor
FORC22_RS15760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC22_RS15775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC22_RS15780	COG0534	Mate efflux family protein
FORC22_RS15785	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC22_RS15790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC22_RS15795	COG2937	Belongs to the GPAT DAPAT family
FORC22_RS15800	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC22_RS15805	COG3161	chorismate lyase activity
FORC22_RS15810	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC22_RS15815	COG0705	Rhomboid family
FORC22_RS15820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC22_RS15835	COG2177	Part of the ABC transporter FtsEX involved in
FORC22_RS15840	COG2884	Cell division ATP-binding protein ftsE
FORC22_RS15845	COG0552	protein localization to endoplasmic reticulum
FORC22_RS15850	COG0742	ribosomal rna small subunit methyltransferase
FORC22_RS15860	COG2095	MarC family integral membrane protein
FORC22_RS15915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC22_RS15920	COG0640	Transcriptional regulator
FORC22_RS15925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC22_RS15930	COG1280	lysine exporter protein (LysE YggA)
FORC22_RS15935	COG2267	carboxylic ester hydrolase activity
FORC22_RS15940	COG0561	phosphatase activity
FORC22_RS15955	COG3148	PFAM DTW domain containing protein
FORC22_RS15960	COG2200	EAL domain
FORC22_RS15960	COG3287	FIST C domain
FORC22_RS15960	COG2199	diguanylate cyclase activity
FORC22_RS15965	COG1011	Hydrolase
FORC22_RS15970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC22_RS15980	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC22_RS15985	COG0019	diaminopimelate decarboxylase activity
FORC22_RS15995	COG1965	Belongs to the frataxin family
FORC22_RS16000	COG3072	Adenylate cyclase
FORC22_RS16005	COG0181	hydroxymethylbilane synthase activity
FORC22_RS16010	COG1587	Uroporphyrinogen-III synthase
FORC22_RS16015	COG2959	enzyme of heme biosynthesis
FORC22_RS16020	COG3071	HemY protein
FORC22_RS16065	COG0633	Ferredoxin
FORC22_RS16070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC22_RS16085	COG3118	belongs to the thioredoxin family
FORC22_RS16090	COG0513	Belongs to the DEAD box helicase family
FORC22_RS16095	COG0248	Ppx GppA phosphatase
FORC22_RS16100	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC22_RS16110	COG0514	ATP-dependent DNA helicase (RecQ)
FORC22_RS16115	COG2962	Rard protein
FORC22_RS16125	COG1280	lysine exporter protein (LysE YggA)
FORC22_RS16130	COG0405	Gamma-glutamyltransferase
FORC22_RS16135	COG0210	DNA helicase
FORC22_RS16145	COG3220	belongs to the UPF0276 family
FORC22_RS16175	COG0006	proline dipeptidase activity
FORC22_RS16175	COG0006	proline dipeptidase activity
FORC22_RS16185	COG2022	thiamine diphosphate biosynthetic process
FORC22_RS16190	COG2104	thiamine diphosphate biosynthetic process
FORC22_RS16195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC22_RS16205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC22_RS16210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC22_RS16265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC22_RS16275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC22_RS16280	COG0408	coproporphyrinogen oxidase activity
FORC22_RS16285	COG0009	L-threonylcarbamoyladenylate synthase
FORC22_RS16290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC22_RS16295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC22_RS16300	COG0551	DNA topoisomerase type I activity
FORC22_RS16305	COG2922	Belongs to the Smg family
FORC22_RS16310	COG0758	DNA mediated transformation
FORC22_RS16320	COG0242	peptide deformylase activity
FORC22_RS16325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC22_RS16330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC22_RS16330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC22_RS16335	COG0569	domain protein
FORC22_RS16340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC22_RS16350	COG1272	protein, Hemolysin III
FORC22_RS16355	COG4326	sporulation control protein
FORC22_RS16360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC22_RS16365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC22_RS16370	COG0706	membrane insertase activity
FORC22_RS16380	COG0594	ribonuclease P activity
FORC22_RS16390	COG1126	abc transporter atp-binding protein
FORC22_RS16590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_RS16965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC22_RS17330	COG2194	sulfuric ester hydrolase activity
FORC22_RS17595	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC22_RS17755	COG3273	potassium ion transport
FORC22_RS17755	COG0471	metal ion transport
FORC22_RS17870	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC22_RS18360	COG1968	undecaprenyl-diphosphatase activity
FORC22_RS18400	COG0306	phosphate transporter
FORC22_RS18435	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC22_RS18665	COG0067	glutamate synthase
FORC22_RS18665	COG0069	glutamate synthase activity
FORC22_RS18665	COG0070	glutamate synthase
FORC22_RS18670	COG0067	glutamate synthase
FORC22_RS18670	COG0069	glutamate synthase activity
FORC22_RS18670	COG0070	glutamate synthase
FORC22_RS18740	COG0784	Response regulator, receiver
FORC22_RS18740	COG2198	Histidine kinase
FORC22_RS18740	COG5002	protein histidine kinase activity
FORC22_RS18790	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC22_RS18980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC22_RS19005	COG3275	phosphorelay sensor kinase activity
FORC22_RS19120	COG0542	response to heat
FORC22_RS19125	COG0542	response to heat
FORC22_RS19270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC22_RS19625	COG1073	alpha beta
FORC22_RS19870	COG0495	leucyl-tRNA aminoacylation
FORC22_RS20115	COG1706	bacterial-type flagellum-dependent cell motility
FORC22_RS20295	COG1053	succinate dehydrogenase
FORC22_RS20315	COG0567	Dehydrogenase, E1 component
FORC22_RS20400	COG1199	ATP-dependent helicase activity
FORC22_RS20700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC22_RS21115	COG0542	response to heat
FORC22_RS21145	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC22_RS21255	COG3070	regulator of competence-specific genes
FORC22_RS21450	COG5002	protein histidine kinase activity
FORC22_RS21450	COG0784	Response regulator, receiver
FORC22_RS22055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC22_RS22370	COG4988	ABC transporter
FORC22_RS22530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC22_RS22875	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC22_RS22985	COG0557	exoribonuclease II activity
FORC22_RS22995	COG0557	exoribonuclease II activity
FORC22_RS23250	COG3300	MHYT domain
FORC22_RS23250	COG5001	Diguanylate cyclase
FORC22_RS23540	COG0443	Heat shock 70 kDa protein
FORC22_RS23605	COG1643	Atp-dependent helicase
FORC22_RS23860	COG4191	Histidine kinase
FORC22_RS24000	COG3842	ATPase activity
FORC22_RS24675	COG1450	Type ii and iii secretion system protein
FORC22_RS24735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC22_RS24890	COG0183	Belongs to the thiolase family
FORC22_RS25170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC22_RS25290	COG2199	diguanylate cyclase activity
FORC22_RS25330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis