locus-tag	class	description
FORC23_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC23_RS00020	COG1126	abc transporter atp-binding protein
FORC23_RS00030	COG0594	ribonuclease P activity
FORC23_RS00035	COG0706	membrane insertase activity
FORC23_RS00040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC23_RS00045	COG4974	Belongs to the 'phage' integrase family
FORC23_RS00075	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FORC23_RS00080	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FORC23_RS00085	COG0732	type I restriction modification DNA specificity domain
FORC23_RS00140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC23_RS00145	COG0445	tRNA wobble uridine modification
FORC23_RS00150	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC23_RS00155	COG1192	Involved in chromosome partitioning
FORC23_RS00160	COG1475	DNA binding
FORC23_RS00165	COG3312	ion transport
FORC23_RS00170	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC23_RS00185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC23_RS00190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC23_RS00195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORC23_RS00200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC23_RS00205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC23_RS00210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC23_RS00215	COG0765	amino acid transport
FORC23_RS00220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC23_RS00225	COG2814	Major facilitator Superfamily
FORC23_RS00230	COG0583	DNA-binding transcription factor activity
FORC23_RS00240	COG0129	dihydroxy-acid dehydratase activity
FORC23_RS00245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC23_RS00250	COG3978	acetolactate synthase activity
FORC23_RS00260	COG0606	chelatase, subunit chli
FORC23_RS00270	COG0204	Acyl-transferase
FORC23_RS00275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC23_RS00280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC23_RS00290	COG3084	Protein conserved in bacteria
FORC23_RS00295	COG4326	sporulation control protein
FORC23_RS00300	COG1272	protein, Hemolysin III
FORC23_RS00310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC23_RS00315	COG0569	domain protein
FORC23_RS00320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC23_RS00320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC23_RS00325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC23_RS00330	COG0242	peptide deformylase activity
FORC23_RS00340	COG0758	DNA mediated transformation
FORC23_RS00345	COG2922	Belongs to the Smg family
FORC23_RS00350	COG0551	DNA topoisomerase type I activity
FORC23_RS00355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC23_RS00360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC23_RS00365	COG0009	L-threonylcarbamoyladenylate synthase
FORC23_RS00370	COG0408	coproporphyrinogen oxidase activity
FORC23_RS00375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC23_RS00385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC23_RS00490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC23_RS00495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC23_RS00500	COG0352	thiamine-phosphate diphosphorylase activity
FORC23_RS00505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC23_RS00510	COG2104	thiamine diphosphate biosynthetic process
FORC23_RS00515	COG2022	thiamine diphosphate biosynthetic process
FORC23_RS00525	COG0006	proline dipeptidase activity
FORC23_RS00525	COG0006	proline dipeptidase activity
FORC23_RS00555	COG3220	belongs to the UPF0276 family
FORC23_RS00565	COG0210	DNA helicase
FORC23_RS00570	COG0405	Gamma-glutamyltransferase
FORC23_RS00575	COG1280	lysine exporter protein (LysE YggA)
FORC23_RS00585	COG2962	Rard protein
FORC23_RS00590	COG0514	ATP-dependent DNA helicase (RecQ)
FORC23_RS00600	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC23_RS00605	COG0248	Ppx GppA phosphatase
FORC23_RS00610	COG0513	Belongs to the DEAD box helicase family
FORC23_RS00615	COG3118	belongs to the thioredoxin family
FORC23_RS00630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC23_RS00680	COG3071	HemY protein
FORC23_RS00685	COG2959	enzyme of heme biosynthesis
FORC23_RS00690	COG1587	Uroporphyrinogen-III synthase
FORC23_RS00695	COG0181	hydroxymethylbilane synthase activity
FORC23_RS00700	COG3072	Adenylate cyclase
FORC23_RS00705	COG1965	Belongs to the frataxin family
FORC23_RS00715	COG0019	diaminopimelate decarboxylase activity
FORC23_RS00720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC23_RS00730	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC23_RS00735	COG1011	Hydrolase
FORC23_RS00740	COG2200	EAL domain
FORC23_RS00740	COG3287	FIST C domain
FORC23_RS00740	COG2199	diguanylate cyclase activity
FORC23_RS00745	COG3148	PFAM DTW domain containing protein
FORC23_RS00760	COG0561	phosphatase activity
FORC23_RS00765	COG2267	carboxylic ester hydrolase activity
FORC23_RS00770	COG1280	lysine exporter protein (LysE YggA)
FORC23_RS00775	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC23_RS00780	COG0640	Transcriptional regulator
FORC23_RS00785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC23_RS00835	COG2095	MarC family integral membrane protein
FORC23_RS00845	COG0742	ribosomal rna small subunit methyltransferase
FORC23_RS00850	COG0552	protein localization to endoplasmic reticulum
FORC23_RS00855	COG2884	Cell division ATP-binding protein ftsE
FORC23_RS00860	COG2177	Part of the ABC transporter FtsEX involved in
FORC23_RS00870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC23_RS00875	COG0705	Rhomboid family
FORC23_RS00880	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC23_RS00885	COG3161	chorismate lyase activity
FORC23_RS00890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC23_RS00895	COG2937	Belongs to the GPAT DAPAT family
FORC23_RS00900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC23_RS00905	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC23_RS00910	COG0534	Mate efflux family protein
FORC23_RS00915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC23_RS00930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC23_RS00935	COG4206	TonB-dependent receptor
FORC23_RS00945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC23_RS01000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC23_RS01010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC23_RS01050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC23_RS01055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC23_RS01060	COG0250	Participates in transcription elongation, termination and antitermination
FORC23_RS01065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC23_RS01070	COG0081	regulation of translation
FORC23_RS01075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC23_RS01080	COG0222	ribosome binding
FORC23_RS01085	COG0085	RNA polymerase activity
FORC23_RS01090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC23_RS01095	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC23_RS01100	COG2816	NAD+ diphosphatase activity
FORC23_RS01115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC23_RS01120	COG1573	uracil-dna glycosylase
FORC23_RS01125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC23_RS01135	COG1253	flavin adenine dinucleotide binding
FORC23_RS01150	COG0151	Belongs to the GarS family
FORC23_RS01155	COG0138	bifunctional purine biosynthesis protein purh
FORC23_RS01160	COG0789	Transcriptional regulator
FORC23_RS01165	COG3710	Transcriptional regulator
FORC23_RS01170	COG0531	amino acid
FORC23_RS01175	COG1982	Orn Lys Arg decarboxylase major
FORC23_RS01240	COG3706	GGDEF domain
FORC23_RS01245	COG0488	(ABC) transporter
FORC23_RS01250	COG2814	Major facilitator Superfamily
FORC23_RS01255	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC23_RS01260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC23_RS01265	COG2264	protein methyltransferase activity
FORC23_RS01270	COG0439	Biotin carboxylase
FORC23_RS01275	COG0511	ligase activity, forming carbon-carbon bonds
FORC23_RS01280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC23_RS01285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC23_RS01300	COG2814	Major facilitator Superfamily
FORC23_RS01305	COG0784	Response regulator, receiver
FORC23_RS01305	COG2198	Histidine kinase
FORC23_RS01305	COG2205	protein histidine kinase activity
FORC23_RS01325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC23_RS01335	COG3263	regulation of cellular component size
FORC23_RS01345	COG4232	protein-disulfide reductase activity
FORC23_RS01350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC23_RS01355	COG1027	Aspartate ammonia-lyase
FORC23_RS01365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC23_RS01375	COG2205	protein histidine kinase activity
FORC23_RS01380	COG0745	RESPONSE REGULATOR receiver
FORC23_RS01385	COG3678	ATP-independent chaperone mediated protein folding
FORC23_RS01395	COG0205	6-phosphofructokinase activity
FORC23_RS01400	COG0534	Mate efflux family protein
FORC23_RS01410	COG0459	protein refolding
FORC23_RS01430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC23_RS01435	COG1509	lysine 2,3-aminomutase activity
FORC23_RS01440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC23_RS01450	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC23_RS01455	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC23_RS01460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC23_RS01465	COG1053	succinate dehydrogenase
FORC23_RS01470	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC23_RS01490	COG4942	peptidase
FORC23_RS01495	COG1045	serine acetyltransferase
FORC23_RS01500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC23_RS01505	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC23_RS01510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC23_RS01515	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC23_RS01525	COG0840	transmembrane signaling receptor activity
FORC23_RS01530	COG0471	metal ion transport
FORC23_RS01535	COG0688	phosphatidylethanolamine metabolic process
FORC23_RS01540	COG1162	GTPase activity
FORC23_RS01545	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC23_RS01615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC23_RS01620	COG0802	atpase or kinase
FORC23_RS01625	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC23_RS01630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC23_RS01635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC23_RS01645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC23_RS01650	COG0330	HflC and HflK could
FORC23_RS01655	COG0330	HflC and HflK could
FORC23_RS01660	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC23_RS01665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC23_RS01670	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC23_RS01675	COG1017	nitric oxide dioxygenase activity
FORC23_RS01675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC23_RS01680	COG1959	2 iron, 2 sulfur cluster binding
FORC23_RS01685	COG0557	exoribonuclease II activity
FORC23_RS01690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC23_RS01695	COG0546	phosphoglycolate phosphatase activity
FORC23_RS01700	COG0180	Tryptophanyl-tRNA synthetase
FORC23_RS01715	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC23_RS01720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC23_RS01730	COG1012	belongs to the aldehyde dehydrogenase family
FORC23_RS01740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC23_RS01745	COG3954	Phosphoribulokinase
FORC23_RS01750	COG3089	Belongs to the UPF0270 family
FORC23_RS01755	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC23_RS01765	COG0488	(ABC) transporter
FORC23_RS01770	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC23_RS01785	COG1047	Peptidyl-prolyl cis-trans
FORC23_RS01790	COG1446	asparaginase
FORC23_RS01795	COG2900	Belongs to the SlyX family
FORC23_RS01805	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC23_RS01810	COG2964	Protein conserved in bacteria
FORC23_RS01815	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC23_RS01820	COG2923	Belongs to the DsrF TusC family
FORC23_RS01835	COG0049	tRNA binding
FORC23_RS01840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC23_RS01845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC23_RS01850	COG2906	2 iron, 2 sulfur cluster binding
FORC23_RS01860	COG0281	malic enzyme
FORC23_RS01870	COG0626	cystathionine gamma-synthase activity
FORC23_RS01875	COG0527	aspartate kinase activity
FORC23_RS01875	COG0460	homoserine dehydrogenase
FORC23_RS01880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC23_RS01890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC23_RS01895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC23_RS01900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORC23_RS01905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC23_RS01910	COG0137	argininosuccinate synthase activity
FORC23_RS01915	COG0165	Argininosuccinate lyase
FORC23_RS01915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC23_RS01925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC23_RS01925	COG0678	peroxiredoxin activity
FORC23_RS01935	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC23_RS01965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC23_RS01970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC23_RS01980	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC23_RS01985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC23_RS01990	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC23_RS01995	COG2965	DNA replication, synthesis of RNA primer
FORC23_RS02005	COG0359	binds to the 23S rRNA
FORC23_RS02020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC23_RS02030	COG0432	Pfam Uncharacterised protein family UPF0047
FORC23_RS02035	COG0166	Belongs to the GPI family
FORC23_RS02045	COG0735	belongs to the Fur family
FORC23_RS02050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC23_RS02070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC23_RS02075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC23_RS02080	COG0175	sulfate reduction
FORC23_RS02145	COG0646	methionine synthase
FORC23_RS02145	COG1410	methionine synthase
FORC23_RS02150	COG0527	aspartate kinase activity
FORC23_RS02160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC23_RS02170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC23_RS02185	COG0629	single-stranded DNA binding
FORC23_RS02190	COG2199	diguanylate cyclase activity
FORC23_RS02190	COG2200	EAL domain
FORC23_RS02215	COG3409	Peptidoglycan-binding domain 1 protein
FORC23_RS02215	COG3267	Type II secretory pathway component ExeA
FORC23_RS02225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC23_RS02230	COG1459	type II secretion system
FORC23_RS02240	COG2165	general secretion pathway protein
FORC23_RS02275	COG1077	Cell shape determining protein MreB Mrl
FORC23_RS02280	COG1792	Involved in formation and maintenance of cell shape
FORC23_RS02285	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC23_RS02290	COG0424	maF-like protein
FORC23_RS02300	COG3164	Protein of unknown function
FORC23_RS02305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC23_RS02310	COG0312	modulator of DNA gyrase
FORC23_RS02315	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC23_RS02320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC23_RS02330	COG0564	pseudouridine synthase activity
FORC23_RS02335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC23_RS02340	COG3028	Belongs to the UPF0307 family
FORC23_RS02345	COG0312	modulator of DNA gyrase
FORC23_RS02350	COG2239	Acts as a magnesium transporter
FORC23_RS02355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC23_RS02360	COG1660	Displays ATPase and GTPase activities
FORC23_RS02365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC23_RS02370	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC23_RS02380	COG1137	ATPase activity
FORC23_RS02385	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC23_RS02395	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC23_RS02395	COG0517	IMP dehydrogenase activity
FORC23_RS02405	COG1127	ABC transporter
FORC23_RS02410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC23_RS02415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC23_RS02420	COG2854	intermembrane phospholipid transfer
FORC23_RS02430	COG5007	Belongs to the BolA IbaG family
FORC23_RS02435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC23_RS02440	COG0204	Acyl-transferase
FORC23_RS02445	COG0251	oxidation-reduction process
FORC23_RS02450	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC23_RS02455	COG0540	Belongs to the ATCase OTCase family
FORC23_RS02460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FORC23_RS02465	COG2235	arginine
FORC23_RS02490	COG0525	valine-tRNA ligase activity
FORC23_RS02495	COG2927	DNA polymerase III (CHI subunit)
FORC23_RS02500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC23_RS02505	COG0795	lipopolysaccharide-transporting ATPase activity
FORC23_RS02510	COG0795	lipopolysaccharide-transporting ATPase activity
FORC23_RS02525	COG1028	Short-chain dehydrogenase reductase Sdr
FORC23_RS02535	COG0726	polysaccharide deacetylase
FORC23_RS02540	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC23_RS02545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC23_RS02550	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC23_RS02555	COG1486	melibiose metabolic process
FORC23_RS02560	COG3394	polysaccharide catabolic process
FORC23_RS02570	COG3437	response regulator, receiver
FORC23_RS02615	COG1012	belongs to the aldehyde dehydrogenase family
FORC23_RS02645	COG0840	transmembrane signaling receptor activity
FORC23_RS02685	COG0741	lytic transglycosylase activity
FORC23_RS02690	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC23_RS02700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC23_RS02710	COG2066	Belongs to the glutaminase family
FORC23_RS02715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC23_RS02720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC23_RS02730	COG1872	DUF167
FORC23_RS02735	COG0762	integral membrane protein
FORC23_RS02740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC23_RS02745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC23_RS02760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC23_RS02765	COG1678	Uncharacterized ACR, COG1678
FORC23_RS02770	COG0189	ligase activity
FORC23_RS02775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC23_RS02780	COG2356	endonuclease I
FORC23_RS02785	COG3091	SprT-like family
FORC23_RS02795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC23_RS02805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC23_RS02810	COG0583	DNA-binding transcription factor activity
FORC23_RS02815	COG4771	TonB-dependent receptor
FORC23_RS02820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC23_RS02825	COG0126	phosphoglycerate kinase activity
FORC23_RS02830	COG0191	fructose-bisphosphate aldolase activity
FORC23_RS02835	COG0668	transmembrane transport
FORC23_RS02840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC23_RS02850	COG0583	DNA-binding transcription factor activity
FORC23_RS02860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC23_RS02865	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC23_RS02870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC23_RS02880	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC23_RS02885	COG3079	Belongs to the UPF0149 family
FORC23_RS02890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC23_RS02895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC23_RS02910	COG0354	folic acid binding
FORC23_RS02915	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FORC23_RS02920	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC23_RS02925	COG1595	DNA-templated transcription, initiation
FORC23_RS02930	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC23_RS02940	COG3086	response to oxidative stress
FORC23_RS02945	COG0481	GTPase activity
FORC23_RS02955	COG0571	ribonuclease III activity
FORC23_RS02960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC23_RS02965	COG1381	Involved in DNA repair and RecF pathway recombination
FORC23_RS02970	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC23_RS02975	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC23_RS02985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC23_RS02990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC23_RS02995	COG3956	TIGRFAM MazG family protein
FORC23_RS03000	COG0504	CTP synthase activity
FORC23_RS03005	COG0148	phosphopyruvate hydratase activity
FORC23_RS03010	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC23_RS03015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC23_RS03020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC23_RS03025	COG0585	pseudouridine synthase activity
FORC23_RS03030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC23_RS03035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC23_RS03045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC23_RS03050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC23_RS03055	COG1546	Belongs to the CinA family
FORC23_RS03060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC23_RS03065	COG2137	regulation of response to DNA damage stimulus
FORC23_RS03070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC23_RS03075	COG0527	aspartate kinase activity
FORC23_RS03135	COG3630	sodium ion export across plasma membrane
FORC23_RS03140	COG0511	ligase activity, forming carbon-carbon bonds
FORC23_RS03140	COG5016	pyruvate
FORC23_RS03145	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC23_RS03155	COG1238	metal cluster binding
FORC23_RS03160	COG0612	Peptidase, M16
FORC23_RS03165	COG2918	glutathione biosynthetic process
FORC23_RS03175	COG1854	S-ribosylhomocysteine lyase activity
FORC23_RS03180	COG4536	flavin adenine dinucleotide binding
FORC23_RS03185	COG4137	Cytochrome C assembly protein
FORC23_RS03190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC23_RS03195	COG0228	four-way junction DNA binding
FORC23_RS03200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC23_RS03205	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC23_RS03210	COG0335	large ribosomal subunit rRNA binding
FORC23_RS03215	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC23_RS03220	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC23_RS03225	COG0237	dephospho-CoA kinase activity
FORC23_RS03235	COG1459	type II secretion system
FORC23_RS03240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC23_RS03250	COG0157	Belongs to the NadC ModD family
FORC23_RS03260	COG2186	Transcriptional regulator
FORC23_RS03265	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC23_RS03270	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC23_RS03275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC23_RS03290	COG0288	reversible hydration of carbon dioxide
FORC23_RS03295	COG0659	secondary active sulfate transmembrane transporter activity
FORC23_RS03300	COG1131	(ABC) transporter
FORC23_RS03305	COG0842	Transport permease protein
FORC23_RS03310	COG1560	Kdo2-lipid A biosynthetic process
FORC23_RS03315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC23_RS03320	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC23_RS03325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC23_RS03335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC23_RS03345	COG1489	DNA binding
FORC23_RS03350	COG1643	Atp-dependent helicase
FORC23_RS03355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC23_RS03360	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC23_RS03365	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC23_RS03370	COG3112	Uncharacterised protein family (UPF0231)
FORC23_RS03380	COG0004	ammonium transporteR
FORC23_RS03385	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC23_RS03395	COG3842	ATPase activity
FORC23_RS03400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC23_RS03415	COG2971	BadF BadG BcrA BcrD
FORC23_RS03425	COG4608	Belongs to the ABC transporter superfamily
FORC23_RS03430	COG0444	Belongs to the ABC transporter superfamily
FORC23_RS03435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC23_RS03445	COG0747	negative chemotaxis
FORC23_RS03450	COG2205	protein histidine kinase activity
FORC23_RS03450	COG2198	Histidine kinase
FORC23_RS03450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC23_RS03450	COG0784	Response regulator, receiver
FORC23_RS03455	COG2813	Specifically methylates the guanine in position
FORC23_RS03460	COG0628	permease
FORC23_RS03465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC23_RS03470	COG0316	Belongs to the HesB IscA family
FORC23_RS03480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC23_RS03485	COG0739	heme binding
FORC23_RS03490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC23_RS03500	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC23_RS03505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC23_RS03510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC23_RS03515	COG1534	Rna-binding protein
FORC23_RS03520	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC23_RS03525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC23_RS03530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC23_RS03535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC23_RS03545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC23_RS03560	COG0779	Required for maturation of 30S ribosomal subunits
FORC23_RS03565	COG0195	Participates in both transcription termination and antitermination
FORC23_RS03570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC23_RS03575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC23_RS03580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC23_RS03585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC23_RS03590	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC23_RS03605	COG0534	Mate efflux family protein
FORC23_RS03610	COG0826	peptidase U32
FORC23_RS03615	COG0826	peptidase U32
FORC23_RS03625	COG3154	lipid carrier protein
FORC23_RS03630	COG3153	acetyltransferase
FORC23_RS03650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC23_RS03660	COG0084	hydrolase, TatD family'
FORC23_RS03665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC23_RS03670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC23_RS03675	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC23_RS03680	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC23_RS03685	COG0813	purine-nucleoside phosphorylase activity
FORC23_RS03695	COG0560	Phosphoserine phosphatase
FORC23_RS03705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC23_RS03710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC23_RS03715	COG0583	DNA-binding transcription factor activity
FORC23_RS03725	COG1022	Amp-dependent synthetase and ligase
FORC23_RS03730	COG2169	Transcriptional regulator
FORC23_RS03750	COG4964	Belongs to the GSP D family
FORC23_RS03810	COG0583	DNA-binding transcription factor activity
FORC23_RS03815	COG0531	amino acid
FORC23_RS03820	COG2731	YhcH YjgK YiaL family protein
FORC23_RS03825	COG3250	beta-galactosidase activity
FORC23_RS03830	COG1609	Transcriptional regulator
FORC23_RS03835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC23_RS03840	COG1085	galactose-1-phosphate uridylyltransferase
FORC23_RS03845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC23_RS03850	COG2017	converts alpha-aldose to the beta-anomer
FORC23_RS03865	COG2211	Major facilitator Superfamily
FORC23_RS03870	COG1609	Transcriptional regulator
FORC23_RS03875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC23_RS03895	COG0598	Magnesium transport protein CorA
FORC23_RS03900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC23_RS03905	COG1349	DNA-binding transcription factor activity
FORC23_RS03910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC23_RS03915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC23_RS03920	COG2271	Major facilitator Superfamily
FORC23_RS03925	COG0584	glycerophosphoryl diester phosphodiesterase
FORC23_RS03930	COG2171	N-acyltransferase activity
FORC23_RS03935	COG3141	response to X-ray
FORC23_RS03955	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC23_RS03965	COG1074	ATP-dependent DNA helicase activity
FORC23_RS03970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC23_RS03975	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC23_RS03975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC23_RS03985	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC23_RS03990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC23_RS03995	COG2166	iron-sulfur cluster assembly
FORC23_RS04000	COG3706	GGDEF domain
FORC23_RS04005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC23_RS04010	COG0693	protein deglycase activity
FORC23_RS04015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC23_RS04040	COG1595	DNA-templated transcription, initiation
FORC23_RS04060	COG3056	Lipoprotein
FORC23_RS04065	COG2813	Specifically methylates the guanine in position
FORC23_RS04070	COG0271	Belongs to the BolA IbaG family
FORC23_RS04080	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC23_RS04085	COG1805	sodium ion transport
FORC23_RS04090	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC23_RS04095	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC23_RS04100	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC23_RS04105	COG2871	sodium ion transport
FORC23_RS04110	COG1477	protein flavinylation
FORC23_RS04125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC23_RS04130	COG0514	ATP-dependent DNA helicase (RecQ)
FORC23_RS04135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC23_RS04150	COG0733	neurotransmitter:sodium symporter activity
FORC23_RS04170	COG0442	prolyl-tRNA aminoacylation
FORC23_RS04175	COG1720	tRNA m6t6A37 methyltransferase activity
FORC23_RS04180	COG0254	rRNA binding
FORC23_RS04185	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC23_RS04190	COG1671	Belongs to the UPF0178 family
FORC23_RS04215	COG3098	single-species biofilm formation
FORC23_RS04220	COG0564	pseudouridine synthase activity
FORC23_RS04230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC23_RS04235	COG0024	Methionine aminopeptidase
FORC23_RS04240	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC23_RS04245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC23_RS04250	COG0528	UMP kinase activity
FORC23_RS04255	COG0233	cytoplasmic translational termination
FORC23_RS04260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC23_RS04265	COG0575	Belongs to the CDS family
FORC23_RS04270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC23_RS04275	COG0750	zinc metalloprotease
FORC23_RS04285	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC23_RS04290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC23_RS04295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC23_RS04300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC23_RS04305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC23_RS04310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC23_RS04315	COG0587	DNA-directed DNA polymerase activity
FORC23_RS04320	COG0825	malonyl-CoA metabolic process
FORC23_RS04325	COG0037	tRNA processing
FORC23_RS04335	COG0347	Belongs to the P(II) protein family
FORC23_RS04340	COG3021	interspecies interaction between organisms
FORC23_RS04350	COG1388	LysM domain
FORC23_RS04350	COG0741	lytic transglycosylase activity
FORC23_RS04355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC23_RS04360	COG2226	methyltransferase
FORC23_RS04365	COG0328	RNA-DNA hybrid ribonuclease activity
FORC23_RS04370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC23_RS04390	COG0456	acetyltransferase
FORC23_RS04400	COG1960	acyl-CoA dehydrogenase activity
FORC23_RS04405	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC23_RS04410	COG0121	glutamine amidotransferase
FORC23_RS04415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC23_RS04420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC23_RS04425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC23_RS04430	COG2233	PERMEase
FORC23_RS04450	COG1393	Belongs to the ArsC family
FORC23_RS04455	COG4783	chaperone-mediated protein folding
FORC23_RS04470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC23_RS04475	COG2716	regulation of RNA biosynthetic process
FORC23_RS04480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC23_RS04485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FORC23_RS04500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC23_RS04505	COG1393	Belongs to the ArsC family
FORC23_RS04530	COG2837	iron assimilation
FORC23_RS04535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC23_RS04540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC23_RS04545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC23_RS04550	COG1334	flagellar protein FlaG
FORC23_RS04555	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC23_RS04565	COG1516	flagellar protein fliS
FORC23_RS04585	COG1677	Flagellar hook-basal body complex protein FliE
FORC23_RS04595	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC23_RS04645	COG1987	bacterial-type flagellum assembly
FORC23_RS04650	COG1684	flagellar biosynthetic protein fliR
FORC23_RS04685	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC23_RS04690	COG0643	Histidine kinase
FORC23_RS04690	COG0784	Response regulator, receiver
FORC23_RS04690	COG2198	Histidine kinase
FORC23_RS04695	COG2201	protein-glutamate methylesterase activity
FORC23_RS04700	COG1192	Involved in chromosome partitioning
FORC23_RS04710	COG0835	chemotaxis
FORC23_RS04720	COG4133	protoheme IX ABC transporter activity
FORC23_RS04725	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC23_RS04730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC23_RS04735	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC23_RS04740	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC23_RS04745	COG1138	Cytochrome C-type biogenesis protein
FORC23_RS04750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC23_RS04765	COG2853	Lipoprotein
FORC23_RS04775	COG2067	long-chain fatty acid transport protein
FORC23_RS04790	COG0183	Belongs to the thiolase family
FORC23_RS04795	COG1024	Enoyl-CoA hydratase
FORC23_RS04795	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC23_RS04810	COG2062	phosphohistidine phosphatase, SixA
FORC23_RS04815	COG2840	Smr protein MutS2
FORC23_RS04820	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC23_RS04825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC23_RS04830	COG2860	membrane
FORC23_RS04835	COG3101	peptidyl-lysine hydroxylation
FORC23_RS04845	COG0431	NADPH-dependent FMN reductase
FORC23_RS04850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC23_RS04850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC23_RS04855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC23_RS04860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC23_RS04865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC23_RS04875	COG0101	tRNA pseudouridine synthase activity
FORC23_RS04880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC23_RS04885	COG0285	dihydrofolate synthase activity
FORC23_RS04890	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC23_RS04895	COG1286	toxin biosynthetic process
FORC23_RS04900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC23_RS04905	COG0583	DNA-binding transcription factor activity
FORC23_RS04910	COG0745	RESPONSE REGULATOR receiver
FORC23_RS04915	COG2832	Protein of unknown function (DUF454)
FORC23_RS04920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC23_RS04930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC23_RS04935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC23_RS04940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC23_RS04945	COG0814	amino acid
FORC23_RS04950	COG0251	oxidation-reduction process
FORC23_RS04955	COG3681	Belongs to the UPF0597 family
FORC23_RS04970	COG2261	transglycosylase associated protein
FORC23_RS04975	COG2983	Belongs to the UPF0260 family
FORC23_RS04980	COG0668	transmembrane transport
FORC23_RS04985	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC23_RS04990	COG0346	lactoylglutathione lyase activity
FORC23_RS05000	COG1785	Belongs to the alkaline phosphatase family
FORC23_RS05015	COG2226	methyltransferase
FORC23_RS05030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC23_RS05035	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC23_RS05045	COG3139	Protein of unknown function (DUF1315)
FORC23_RS05050	COG0252	asparaginase activity
FORC23_RS05055	COG0616	signal peptide processing
FORC23_RS05060	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC23_RS05060	COG1902	pentaerythritol trinitrate reductase activity
FORC23_RS05065	COG0778	Nitroreductase
FORC23_RS05070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC23_RS05085	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC23_RS05095	COG3083	sulfuric ester hydrolase activity
FORC23_RS05100	COG3082	Protein of unknown function (DUF1414)
FORC23_RS05105	COG3081	Nucleoid-associated protein
FORC23_RS05120	COG1757	Na H antiporter
FORC23_RS05125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC23_RS05130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC23_RS05135	COG2095	MarC family integral membrane protein
FORC23_RS05140	COG1012	belongs to the aldehyde dehydrogenase family
FORC23_RS05140	COG1454	alcohol dehydrogenase
FORC23_RS05160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC23_RS05170	COG2056	Na+-H+ antiporter family
FORC23_RS05175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC23_RS05180	COG2885	chlorophyll binding
FORC23_RS05190	COG0346	lactoylglutathione lyase activity
FORC23_RS05195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC23_RS05200	COG4660	Part of a membrane complex involved in electron transport
FORC23_RS05205	COG4659	FMN binding
FORC23_RS05210	COG4658	electron transport chain
FORC23_RS05215	COG4656	Part of a membrane complex involved in electron transport
FORC23_RS05220	COG2878	Part of a membrane complex involved in electron transport
FORC23_RS05225	COG4657	Part of a membrane complex involved in electron transport
FORC23_RS05235	COG0556	nucleotide-excision repair
FORC23_RS05240	COG2204	response regulator
FORC23_RS05245	COG2198	Histidine kinase
FORC23_RS05250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC23_RS05255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC23_RS05260	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC23_RS05265	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC23_RS05270	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC23_RS05275	COG0314	molybdopterin synthase activity
FORC23_RS05285	COG0601	transmembrane transport
FORC23_RS05290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC23_RS05295	COG0444	Belongs to the ABC transporter superfamily
FORC23_RS05305	COG0435	Glutathione S-transferase
FORC23_RS05315	COG3174	membrane
FORC23_RS05320	COG0857	belongs to the CobB CobQ family
FORC23_RS05320	COG0280	phosphate acetyltransferase
FORC23_RS05325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC23_RS05330	COG3092	negative regulation of chromosome organization
FORC23_RS05340	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC23_RS05345	COG1122	ATPase activity
FORC23_RS05350	COG0366	Alpha amylase catalytic
FORC23_RS05360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC23_RS05365	COG0653	protein targeting
FORC23_RS05370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC23_RS05375	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC23_RS05380	COG2186	Transcriptional regulator
FORC23_RS05390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC23_RS05390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC23_RS05395	COG0489	protein tyrosine kinase activity
FORC23_RS05400	COG0572	uridine kinase
FORC23_RS05410	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC23_RS05415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC23_RS05420	COG0659	secondary active sulfate transmembrane transporter activity
FORC23_RS05425	COG1530	ribonuclease E activity
FORC23_RS05430	COG0564	pseudouridine synthase activity
FORC23_RS05435	COG0424	maF-like protein
FORC23_RS05440	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC23_RS05450	COG0416	fatty acid biosynthetic process
FORC23_RS05455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC23_RS05485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC23_RS05490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC23_RS05500	COG0084	hydrolase, TatD family'
FORC23_RS05505	COG1263	PTS System
FORC23_RS05505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC23_RS05515	COG0733	neurotransmitter:sodium symporter activity
FORC23_RS05525	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC23_RS05530	COG0469	pyruvate kinase activity
FORC23_RS05535	COG1940	carbohydrate kinase activity
FORC23_RS05540	COG0835	chemotaxis
FORC23_RS05540	COG0784	Response regulator, receiver
FORC23_RS05545	COG0587	DNA-directed DNA polymerase activity
FORC23_RS05560	COG1028	Short-chain dehydrogenase reductase Sdr
FORC23_RS05565	COG0616	signal peptide processing
FORC23_RS05570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC23_RS05575	COG0539	negative regulation of cytoplasmic translation
FORC23_RS05585	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC23_RS05590	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC23_RS05595	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC23_RS05600	COG4166	transmembrane transport
FORC23_RS05615	COG0463	Glycosyl transferase, family 2
FORC23_RS05625	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC23_RS05635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC23_RS05635	COG3008	intermembrane lipid transfer
FORC23_RS05640	COG2995	paraquat-inducible protein a
FORC23_RS05645	COG3258	Cytochrome c
FORC23_RS05650	COG2863	cytochrome
FORC23_RS05690	COG4232	protein-disulfide reductase activity
FORC23_RS05695	COG3118	belongs to the thioredoxin family
FORC23_RS05715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC23_RS05725	COG0577	efflux transmembrane transporter activity
FORC23_RS05725	COG1136	(ABC) transporter
FORC23_RS05730	COG0577	efflux transmembrane transporter activity
FORC23_RS05730	COG1136	(ABC) transporter
FORC23_RS05735	COG1136	(ABC) transporter
FORC23_RS05735	COG0577	efflux transmembrane transporter activity
FORC23_RS05740	COG1335	isochorismatase
FORC23_RS05790	COG5002	protein histidine kinase activity
FORC23_RS05790	COG3850	Histidine kinase
FORC23_RS05795	COG0745	RESPONSE REGULATOR receiver
FORC23_RS05800	COG0840	transmembrane signaling receptor activity
FORC23_RS05805	COG1032	radical SAM domain protein
FORC23_RS05810	COG4251	negative regulation of phosphorylation
FORC23_RS05810	COG2203	Gaf domain
FORC23_RS05810	COG3706	GGDEF domain
FORC23_RS05810	COG5001	Diguanylate cyclase
FORC23_RS05825	COG0583	DNA-binding transcription factor activity
FORC23_RS05830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC23_RS05840	COG2350	Protein conserved in bacteria
FORC23_RS05850	COG2917	probably involved in intracellular septation
FORC23_RS05870	COG1301	dicarboxylic acid transport
FORC23_RS05875	COG0318	PFAM AMP-dependent synthetase and ligase
FORC23_RS05880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC23_RS05885	COG0159	tryptophan synthase activity
FORC23_RS05890	COG0133	tryptophan synthase activity
FORC23_RS05895	COG0135	phosphoribosylanthranilate isomerase activity
FORC23_RS05895	COG0134	indole-3-glycerol-phosphate synthase activity
FORC23_RS05900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC23_RS05905	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC23_RS05910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC23_RS05920	COG0613	PHP domain protein
FORC23_RS05925	COG0009	L-threonylcarbamoyladenylate synthase
FORC23_RS05935	COG1187	pseudouridine synthase activity
FORC23_RS05940	COG3099	Belongs to the UPF0263 family
FORC23_RS05945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC23_RS05955	COG0417	DNA replication proofreading
FORC23_RS05960	COG2197	response regulator
FORC23_RS05965	COG0322	excinuclease ABC activity
FORC23_RS06005	COG0019	diaminopimelate decarboxylase activity
FORC23_RS06030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC23_RS06035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC23_RS06040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC23_RS06060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC23_RS06070	COG0437	4 iron, 4 sulfur cluster binding
FORC23_RS06075	COG3301	Polysulphide reductase, NrfD
FORC23_RS06080	COG1138	Cytochrome C-type biogenesis protein
FORC23_RS06090	COG3088	subunit of a heme lyase
FORC23_RS06090	COG4235	cytochrome complex assembly
FORC23_RS06100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC23_RS06125	COG2989	Protein conserved in bacteria
FORC23_RS06130	COG3108	Peptidase M15
FORC23_RS06135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC23_RS06150	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC23_RS06175	COG1846	Transcriptional regulator
FORC23_RS06180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC23_RS06205	COG1448	Aminotransferase
FORC23_RS06220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC23_RS06230	COG0017	Asparaginyl-tRNA synthetase
FORC23_RS06235	COG0840	transmembrane signaling receptor activity
FORC23_RS06240	COG0720	synthase
FORC23_RS06250	COG2200	EAL domain
FORC23_RS06255	COG1760	l-serine dehydratase
FORC23_RS06260	COG0814	amino acid
FORC23_RS06265	COG0494	nUDIX hydrolase
FORC23_RS06275	COG0784	Response regulator, receiver
FORC23_RS06275	COG2205	protein histidine kinase activity
FORC23_RS06280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC23_RS06295	COG3106	COG3106 Predicted ATPase
FORC23_RS06300	COG3768	UPF0283 membrane protein
FORC23_RS06310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC23_RS06345	COG0346	lactoylglutathione lyase activity
FORC23_RS06385	COG0456	acetyltransferase
FORC23_RS06390	COG0251	oxidation-reduction process
FORC23_RS06535	COG0582	viral genome integration into host DNA
FORC23_RS06800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC23_RS06805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC23_RS06880	COG0346	lactoylglutathione lyase activity
FORC23_RS06935	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC23_RS06940	COG0583	DNA-binding transcription factor activity
FORC23_RS06975	COG0471	metal ion transport
FORC23_RS06980	COG4191	Histidine kinase
FORC23_RS06980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC23_RS06990	COG5001	Diguanylate cyclase
FORC23_RS06990	COG3300	MHYT domain
FORC23_RS07000	COG1280	lysine exporter protein (LysE YggA)
FORC23_RS07005	COG1328	CTP reductase activity
FORC23_RS07010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC23_RS07020	COG0861	Integral membrane protein TerC family
FORC23_RS07030	COG1368	sulfuric ester hydrolase activity
FORC23_RS07035	COG0642	Histidine kinase
FORC23_RS07040	COG0745	RESPONSE REGULATOR receiver
FORC23_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
FORC23_RS07060	COG1022	Amp-dependent synthetase and ligase
FORC23_RS07070	COG2113	Glycine betaine
FORC23_RS07075	COG4176	ABC-type proline glycine betaine transport system permease component
FORC23_RS07095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC23_RS07100	COG0456	acetyltransferase
FORC23_RS07105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC23_RS07110	COG0662	Cupin 2, conserved barrel domain protein
FORC23_RS07115	COG0527	aspartate kinase activity
FORC23_RS07120	COG1858	cytochrome C peroxidase
FORC23_RS07135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC23_RS07150	COG3290	protein histidine kinase activity
FORC23_RS07155	COG4565	transcriptional regulatory protein
FORC23_RS07160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC23_RS07165	COG0363	glucosamine-6-phosphate deaminase activity
FORC23_RS07170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC23_RS07180	COG3284	Transcriptional regulator
FORC23_RS07185	COG1012	belongs to the aldehyde dehydrogenase family
FORC23_RS07255	COG4669	(LipO)protein
FORC23_RS07275	COG3177	Filamentation induced by cAMP protein fic
FORC23_RS07305	COG1073	alpha beta
FORC23_RS07310	COG1073	alpha beta
FORC23_RS07320	COG4792	protein secretion
FORC23_RS07325	COG4791	protein targeting
FORC23_RS07330	COG4794	Type iii secretion
FORC23_RS07335	COG4790	Type iii secretion
FORC23_RS07405	COG0457	Tetratricopeptide repeat
FORC23_RS07425	COG0730	response to heat
FORC23_RS07455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC23_RS07460	COG0372	Belongs to the citrate synthase family
FORC23_RS07470	COG2828	Protein conserved in bacteria
FORC23_RS07495	COG0561	phosphatase activity
FORC23_RS07500	COG0602	queuosine metabolic process
FORC23_RS07505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC23_RS07510	COG3706	GGDEF domain
FORC23_RS07550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC23_RS07555	COG0840	transmembrane signaling receptor activity
FORC23_RS07560	COG1254	Belongs to the acylphosphatase family
FORC23_RS07565	COG2920	part of a sulfur-relay system
FORC23_RS07575	COG0670	Belongs to the BI1 family
FORC23_RS07580	COG1126	abc transporter atp-binding protein
FORC23_RS07585	COG0765	amino acid transport
FORC23_RS07590	COG4597	amino acid ABC transporter
FORC23_RS07595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC23_RS07605	COG1666	GTP binding
FORC23_RS07610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC23_RS07630	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FORC23_RS07630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC23_RS07635	COG3008	intermembrane lipid transfer
FORC23_RS07640	COG2995	paraquat-inducible protein a
FORC23_RS07645	COG1132	(ABC) transporter
FORC23_RS07650	COG1956	GAF domain-containing protein
FORC23_RS07655	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FORC23_RS07670	COG0308	aminopeptidase N
FORC23_RS07675	COG2902	Dehydrogenase
FORC23_RS07680	COG0167	dihydroorotate dehydrogenase activity
FORC23_RS07690	COG0116	Belongs to the methyltransferase superfamily
FORC23_RS07690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC23_RS07700	COG0488	(ABC) transporter
FORC23_RS07715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC23_RS07720	COG1067	ATP-dependent peptidase activity
FORC23_RS07725	COG3120	sequence-specific DNA binding
FORC23_RS07740	COG2205	protein histidine kinase activity
FORC23_RS07740	COG0784	Response regulator, receiver
FORC23_RS07755	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC23_RS07770	COG2010	Cytochrome c
FORC23_RS07780	COG2217	Heavy metal translocating P-type atpase
FORC23_RS07795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC23_RS07800	COG0589	response to stress
FORC23_RS07805	COG0037	tRNA processing
FORC23_RS07825	COG3842	ATPase activity
FORC23_RS07835	COG1177	transmembrane transport
FORC23_RS07845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC23_RS07850	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC23_RS07860	COG0004	ammonium transporteR
FORC23_RS07865	COG4282	regulation of fungal-type cell wall biogenesis
FORC23_RS07885	COG0437	4 iron, 4 sulfur cluster binding
FORC23_RS07890	COG3383	formate dehydrogenase (NAD+) activity
FORC23_RS07890	COG0243	molybdopterin cofactor binding
FORC23_RS07920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC23_RS07925	COG0488	(ABC) transporter
FORC23_RS07930	COG4191	Histidine kinase
FORC23_RS07935	COG2204	response regulator
FORC23_RS07950	COG3842	ATPase activity
FORC23_RS07955	COG0746	molybdenum cofactor guanylyltransferase activity
FORC23_RS07970	COG1940	carbohydrate kinase activity
FORC23_RS07975	COG3148	PFAM DTW domain containing protein
FORC23_RS08010	COG0840	transmembrane signaling receptor activity
FORC23_RS08015	COG0791	NLP P60 protein
FORC23_RS08025	COG3706	GGDEF domain
FORC23_RS08030	COG2201	protein-glutamate methylesterase activity
FORC23_RS08035	COG3001	Fructosamine kinase
FORC23_RS08045	COG0307	riboflavin synthase, alpha
FORC23_RS08050	COG0534	Mate efflux family protein
FORC23_RS08060	COG1793	dna ligase
FORC23_RS08090	COG2204	response regulator
FORC23_RS08130	COG0438	transferase activity, transferring glycosyl groups
FORC23_RS08135	COG1215	transferase activity, transferring glycosyl groups
FORC23_RS08140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC23_RS08150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC23_RS08165	COG1643	Atp-dependent helicase
FORC23_RS08170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC23_RS08175	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC23_RS08175	COG2221	Nitrite and sulphite reductase 4Fe-4S
FORC23_RS08185	COG3302	dmso reductase anchor subunit
FORC23_RS08190	COG0437	4 iron, 4 sulfur cluster binding
FORC23_RS08195	COG0243	molybdopterin cofactor binding
FORC23_RS08225	COG3706	GGDEF domain
FORC23_RS08235	COG0443	Heat shock 70 kDa protein
FORC23_RS08240	COG0443	Heat shock 70 kDa protein
FORC23_RS08265	COG1132	(ABC) transporter
FORC23_RS08270	COG1132	(ABC) transporter
FORC23_RS08290	COG0814	amino acid
FORC23_RS08300	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC23_RS08325	COG1115	amino acid carrier protein
FORC23_RS08335	COG1280	lysine exporter protein (LysE YggA)
FORC23_RS08340	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC23_RS08345	COG1560	Kdo2-lipid A biosynthetic process
FORC23_RS08350	COG0531	amino acid
FORC23_RS08360	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC23_RS08365	COG3063	Type IV pilus biogenesis stability protein PilW
FORC23_RS08380	COG4999	Histidine kinase
FORC23_RS08380	COG3437	response regulator, receiver
FORC23_RS08380	COG2205	protein histidine kinase activity
FORC23_RS08380	COG3850	Histidine kinase
FORC23_RS08395	COG0110	maltose O-acetyltransferase activity
FORC23_RS08415	COG2315	Protein conserved in bacteria
FORC23_RS08420	COG1846	Transcriptional regulator
FORC23_RS08435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC23_RS08450	COG2200	EAL domain
FORC23_RS08450	COG2771	luxR family
FORC23_RS08455	COG1227	inorganic diphosphatase activity
FORC23_RS08460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC23_RS08465	COG1012	belongs to the aldehyde dehydrogenase family
FORC23_RS08470	COG2957	Belongs to the agmatine deiminase family
FORC23_RS08480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC23_RS08485	COG1012	belongs to the aldehyde dehydrogenase family
FORC23_RS08490	COG1917	Cupin 2, conserved barrel domain protein
FORC23_RS08490	COG1396	sequence-specific DNA binding
FORC23_RS08495	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FORC23_RS08500	COG0174	glutamine synthetase
FORC23_RS08505	COG1757	Na H antiporter
FORC23_RS08525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC23_RS08530	COG1280	lysine exporter protein (LysE YggA)
FORC23_RS08570	COG0625	glutathione transferase activity
FORC23_RS08580	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC23_RS08595	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC23_RS08615	COG0813	purine-nucleoside phosphorylase activity
FORC23_RS08625	COG0601	transmembrane transport
FORC23_RS08630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC23_RS08635	COG0444	Belongs to the ABC transporter superfamily
FORC23_RS08650	COG3291	Pkd domain containing protein
FORC23_RS08660	COG1177	transmembrane transport
FORC23_RS08665	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC23_RS08670	COG3842	ATPase activity
FORC23_RS08675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC23_RS08680	COG2423	ornithine cyclodeaminase activity
FORC23_RS08695	COG3938	Belongs to the proline racemase family
FORC23_RS08725	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC23_RS08730	COG1451	nucleotide metabolic process
FORC23_RS08735	COG3475	LICD family
FORC23_RS08740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC23_RS08745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC23_RS08765	COG0583	DNA-binding transcription factor activity
FORC23_RS08785	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC23_RS08790	COG4139	cobalamin transport
FORC23_RS08795	COG2988	succinylglutamate desuccinylase activity
FORC23_RS08805	COG2062	phosphohistidine phosphatase, SixA
FORC23_RS08815	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC23_RS08820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC23_RS08825	COG0702	epimerase
FORC23_RS08830	COG1823	symporter activity
FORC23_RS08835	COG2925	Exonuclease
FORC23_RS08840	COG1380	Effector of murein hydrolase LrgA
FORC23_RS08845	COG1346	cytolysis
FORC23_RS08850	COG0295	cytidine deaminase activity
FORC23_RS08855	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC23_RS08860	COG0500	methyltransferase
FORC23_RS08870	COG0776	regulation of translation
FORC23_RS08880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC23_RS08880	COG0072	phenylalanine-tRNA ligase activity
FORC23_RS08885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC23_RS08890	COG3706	GGDEF domain
FORC23_RS08920	COG0393	Putative heavy-metal-binding
FORC23_RS08930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC23_RS08940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC23_RS08955	COG2188	Transcriptional regulator
FORC23_RS08960	COG1228	amidohydrolase
FORC23_RS08965	COG0010	Belongs to the arginase family
FORC23_RS08970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC23_RS08975	COG2986	histidine ammonia-lyase
FORC23_RS08990	COG0277	FAD linked oxidase domain protein
FORC23_RS08990	COG0247	lactate metabolic process
FORC23_RS09025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC23_RS09040	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC23_RS09045	COG1643	Atp-dependent helicase
FORC23_RS09050	COG0281	malic enzyme
FORC23_RS09055	COG2949	membrane
FORC23_RS09060	COG0471	metal ion transport
FORC23_RS09085	COG0492	ferredoxin-NADP+ reductase activity
FORC23_RS09090	COG4988	ABC transporter
FORC23_RS09095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC23_RS09100	COG3048	D-serine ammonia-lyase activity
FORC23_RS09105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC23_RS09115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC23_RS09115	COG4191	Histidine kinase
FORC23_RS09130	COG3070	regulator of competence-specific genes
FORC23_RS09145	COG2431	L-lysine efflux transmembrane transporter activity
FORC23_RS09155	COG0076	glutamate decarboxylase activity
FORC23_RS09160	COG1737	Transcriptional regulator
FORC23_RS09170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC23_RS09175	COG3273	potassium ion transport
FORC23_RS09175	COG2985	domain, Protein
FORC23_RS09180	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC23_RS09195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC23_RS09210	COG4181	ATPase activity
FORC23_RS09215	COG0534	Mate efflux family protein
FORC23_RS09220	COG0702	epimerase
FORC23_RS09225	COG3005	denitrification pathway
FORC23_RS09255	COG2814	Major facilitator Superfamily
FORC23_RS09260	COG1187	pseudouridine synthase activity
FORC23_RS09265	COG1061	Type III restriction enzyme res subunit
FORC23_RS09285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC23_RS09310	COG3313	Fe-S protein
FORC23_RS09335	COG0493	'glutamate synthase
FORC23_RS09345	COG0398	Pfam SNARE associated Golgi protein
FORC23_RS09350	COG4134	Bacterial extracellular solute-binding protein
FORC23_RS09355	COG4135	transport system, permease component
FORC23_RS09360	COG4136	ATPase activity
FORC23_RS09365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC23_RS09375	COG3604	Transcriptional regulator
FORC23_RS09380	COG1151	hydroxylamine reductase activity
FORC23_RS09385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC23_RS09395	COG0564	pseudouridine synthase activity
FORC23_RS09405	COG0733	neurotransmitter:sodium symporter activity
FORC23_RS09415	COG0626	cystathionine gamma-synthase activity
FORC23_RS09420	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC23_RS09425	COG5380	lipid catabolic process
FORC23_RS09430	COG2818	Glycosylase
FORC23_RS09445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC23_RS09450	COG1983	PspC domain protein
FORC23_RS09460	COG1842	Phage shock protein A
FORC23_RS09465	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC23_RS09480	COG4171	peptide transport system, permease
FORC23_RS09490	COG4172	Belongs to the ABC transporter superfamily
FORC23_RS09500	COG1227	inorganic diphosphatase activity
FORC23_RS09515	COG0243	molybdopterin cofactor binding
FORC23_RS09520	COG3005	denitrification pathway
FORC23_RS09525	COG4459	periplasmic nitrate reductase
FORC23_RS09530	COG0390	transport system, permease component
FORC23_RS09535	COG2116	formate transmembrane transporter activity
FORC23_RS09560	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC23_RS09565	COG1435	thymidine kinase activity
FORC23_RS09570	COG0215	cysteine-tRNA ligase activity
FORC23_RS09575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC23_RS09580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC23_RS09585	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC23_RS09590	COG3012	SEC-C Motif Domain Protein
FORC23_RS09595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC23_RS09595	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC23_RS09600	COG0107	imidazoleglycerol-phosphate synthase activity
FORC23_RS09605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC23_RS09610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC23_RS09615	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC23_RS09615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC23_RS09620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC23_RS09625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORC23_RS09630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC23_RS09645	COG1757	Na H antiporter
FORC23_RS09655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC23_RS09665	COG0482	sulfurtransferase activity
FORC23_RS09670	COG2915	High frequency lysogenization protein hflD homolog
FORC23_RS09675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC23_RS09695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC23_RS09710	COG1028	Short-chain dehydrogenase reductase Sdr
FORC23_RS09725	COG0501	Belongs to the peptidase M48B family
FORC23_RS09730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC23_RS09740	COG0156	8-amino-7-oxononanoate synthase activity
FORC23_RS09745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC23_RS09750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC23_RS09755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC23_RS09770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC23_RS09775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC23_RS09780	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC23_RS09785	COG1674	ftsk spoiiie
FORC23_RS09795	COG0686	Belongs to the AlaDH PNT family
FORC23_RS09805	COG0583	DNA-binding transcription factor activity
FORC23_RS09820	COG3568	Endonuclease Exonuclease Phosphatase
FORC23_RS09845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC23_RS09850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC23_RS09855	COG0840	transmembrane signaling receptor activity
FORC23_RS09895	COG0784	Response regulator, receiver
FORC23_RS09895	COG5002	protein histidine kinase activity
FORC23_RS09905	COG0754	glutathionylspermidine amidase activity
FORC23_RS09915	COG3766	membrane
FORC23_RS09925	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC23_RS09930	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC23_RS09935	COG2885	chlorophyll binding
FORC23_RS09940	COG0823	Involved in the tonB-independent uptake of proteins
FORC23_RS09955	COG0811	peptide transport
FORC23_RS09960	COG0824	Thioesterase
FORC23_RS09970	COG4890	Cyd operon protein YbgT
FORC23_RS09975	COG1294	oxidase, subunit
FORC23_RS09980	COG1271	oxidase subunit
FORC23_RS09985	COG2255	four-way junction helicase activity
FORC23_RS09990	COG0632	four-way junction helicase activity
FORC23_RS09995	COG0840	transmembrane signaling receptor activity
FORC23_RS10000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC23_RS10005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC23_RS10010	COG1801	Protein of unknown function DUF72
FORC23_RS10015	COG4106	trans-aconitate 2-methyltransferase activity
FORC23_RS10020	COG0500	methyltransferase
FORC23_RS10025	COG4067	protein conserved in archaea
FORC23_RS10025	COG0189	ligase activity
FORC23_RS10040	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC23_RS10045	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC23_RS10050	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC23_RS10055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC23_RS10060	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC23_RS10065	COG0745	RESPONSE REGULATOR receiver
FORC23_RS10070	COG3381	protein complex oligomerization
FORC23_RS10075	COG1609	Transcriptional regulator
FORC23_RS10080	COG3070	regulator of competence-specific genes
FORC23_RS10100	COG0297	glycogen (starch) synthase activity
FORC23_RS10105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC23_RS10110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC23_RS10120	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC23_RS10130	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC23_RS10135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC23_RS10140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC23_RS10150	COG0542	response to heat
FORC23_RS10155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC23_RS10160	COG1278	Cold shock
FORC23_RS10170	COG1187	pseudouridine synthase activity
FORC23_RS10175	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC23_RS10180	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC23_RS10185	COG1199	ATP-dependent helicase activity
FORC23_RS10190	COG0730	response to heat
FORC23_RS10195	COG3923	Primosomal replication protein n
FORC23_RS10205	COG0708	Exodeoxyribonuclease III
FORC23_RS10245	COG1882	Formate acetyltransferase
FORC23_RS10255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC23_RS10265	COG3013	Belongs to the UPF0304 family
FORC23_RS10270	COG2766	serine protein kinase
FORC23_RS10275	COG2718	Belongs to the UPF0229 family
FORC23_RS10280	COG2719	SpoVR family
FORC23_RS10285	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC23_RS10295	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC23_RS10300	COG1132	(ABC) transporter
FORC23_RS10305	COG2333	competence protein COMEC
FORC23_RS10305	COG0658	competence protein
FORC23_RS10315	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC23_RS10320	COG1136	(ABC) transporter
FORC23_RS10325	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC23_RS10335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC23_RS10350	COG1252	NADH dehydrogenase
FORC23_RS10355	COG3150	esterase
FORC23_RS10380	COG0537	adenosine 5'-monophosphoramidase activity
FORC23_RS10405	COG0517	IMP dehydrogenase activity
FORC23_RS10405	COG0516	GMP reductase activity
FORC23_RS10410	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC23_RS10415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC23_RS10420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC23_RS10430	COG2199	diguanylate cyclase activity
FORC23_RS10445	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC23_RS10450	COG1946	Acyl-CoA thioesterase
FORC23_RS10460	COG1522	sequence-specific DNA binding
FORC23_RS10485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC23_RS10490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC23_RS10530	COG0477	Major facilitator Superfamily
FORC23_RS10535	COG2855	membrane
FORC23_RS10555	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC23_RS10560	COG0596	Alpha beta hydrolase
FORC23_RS10565	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC23_RS10570	COG1169	isochorismate synthase
FORC23_RS10575	COG0436	Aminotransferase
FORC23_RS10580	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC23_RS10585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC23_RS10600	COG1555	photosystem II stabilization
FORC23_RS10605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC23_RS10610	COG0776	regulation of translation
FORC23_RS10615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC23_RS10620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC23_RS10630	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC23_RS10645	COG2204	response regulator
FORC23_RS10655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC23_RS10660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC23_RS10665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC23_RS10670	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FORC23_RS10685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC23_RS10690	COG0569	domain protein
FORC23_RS10695	COG0513	Belongs to the DEAD box helicase family
FORC23_RS10700	COG1253	flavin adenine dinucleotide binding
FORC23_RS10735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC23_RS10740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC23_RS10755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC23_RS10760	COG1216	Glycosyl transferase, family 2
FORC23_RS10765	COG2986	histidine ammonia-lyase
FORC23_RS10790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC23_RS10800	COG1028	Short-chain dehydrogenase reductase Sdr
FORC23_RS10820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC23_RS10825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC23_RS10830	COG0583	DNA-binding transcription factor activity
FORC23_RS10835	COG2951	lytic endotransglycosylase activity
FORC23_RS10840	COG3100	YcgL domain-containing protein
FORC23_RS10845	COG0850	regulation of cytokinetic process
FORC23_RS10850	COG2894	cell division
FORC23_RS10855	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC23_RS10860	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC23_RS10865	COG0318	PFAM AMP-dependent synthetase and ligase
FORC23_RS10870	COG2267	carboxylic ester hydrolase activity
FORC23_RS10885	COG1214	PFAM Peptidase M22, glycoprotease
FORC23_RS10890	COG1199	ATP-dependent helicase activity
FORC23_RS10895	COG0788	formyltetrahydrofolate deformylase activity
FORC23_RS10910	COG3102	Protein conserved in bacteria
FORC23_RS10915	COG0018	arginyl-trna synthetase
FORC23_RS10935	COG1918	ferrous iron import across plasma membrane
FORC23_RS10940	COG4977	sequence-specific DNA binding
FORC23_RS10945	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC23_RS10950	COG1121	(ABC) transporter
FORC23_RS10955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC23_RS10965	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC23_RS10970	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC23_RS10975	COG0567	Dehydrogenase, E1 component
FORC23_RS10980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC23_RS10985	COG1053	succinate dehydrogenase
FORC23_RS10990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC23_RS11005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC23_RS11015	COG0033	Phosphoglucomutase
FORC23_RS11020	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC23_RS11025	COG0596	Alpha beta hydrolase
FORC23_RS11045	COG0735	belongs to the Fur family
FORC23_RS11050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC23_RS11055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC23_RS11055	COG1263	PTS System
FORC23_RS11060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC23_RS11065	COG1940	carbohydrate kinase activity
FORC23_RS11065	COG1846	Transcriptional regulator
FORC23_RS11070	COG4651	solute:proton antiporter activity
FORC23_RS11070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC23_RS11075	COG0367	asparagine synthase
FORC23_RS11080	COG0250	Participates in transcription elongation, termination and antitermination
FORC23_RS11085	COG3104	oligopeptide transport
FORC23_RS11090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC23_RS11095	COG0563	adenylate kinase activity
FORC23_RS11100	COG0326	Molecular chaperone. Has ATPase activity
FORC23_RS11105	COG3710	Transcriptional regulator
FORC23_RS11125	COG0622	Phosphoesterase
FORC23_RS11150	COG1090	epimerase
FORC23_RS11155	COG0300	oxidoreductase activity
FORC23_RS11160	COG3118	belongs to the thioredoxin family
FORC23_RS11165	COG3118	belongs to the thioredoxin family
FORC23_RS11165	COG0457	Tetratricopeptide repeat
FORC23_RS11170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FORC23_RS11175	COG1215	transferase activity, transferring glycosyl groups
FORC23_RS11180	COG1215	transferase activity, transferring glycosyl groups
FORC23_RS11200	COG2194	sulfuric ester hydrolase activity
FORC23_RS11205	COG0330	HflC and HflK could
FORC23_RS11225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC23_RS11230	COG3115	cell septum assembly
FORC23_RS11235	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC23_RS11240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC23_RS11245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC23_RS11250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC23_RS11255	COG2190	(PTS) system
FORC23_RS11260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC23_RS11265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC23_RS11270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC23_RS11275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC23_RS11285	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC23_RS11285	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC23_RS11290	COG1706	bacterial-type flagellum-dependent cell motility
FORC23_RS11295	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC23_RS11305	COG4787	bacterial-type flagellum-dependent cell motility
FORC23_RS11310	COG1749	Flagellar hook protein flgE
FORC23_RS11320	COG1558	bacterial-type flagellum-dependent cell motility
FORC23_RS11325	COG1815	bacterial-type flagellum-dependent cell motility
FORC23_RS11330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC23_RS11335	COG0784	Response regulator, receiver
FORC23_RS11335	COG0835	chemotaxis
FORC23_RS11385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC23_RS11390	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC23_RS11400	COG2608	mercury ion transmembrane transporter activity
FORC23_RS11400	COG2217	Heavy metal translocating P-type atpase
FORC23_RS11435	COG2840	Smr protein MutS2
FORC23_RS11440	COG1187	pseudouridine synthase activity
FORC23_RS11450	COG0737	Belongs to the 5'-nucleotidase family
FORC23_RS11455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC23_RS11460	COG2912	Transglutaminase-like superfamily
FORC23_RS11465	COG3094	Invasion gene expression up-regulator, SirB
FORC23_RS11470	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC23_RS11475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC23_RS11480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC23_RS11485	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC23_RS11490	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC23_RS11495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC23_RS11500	COG0193	aminoacyl-tRNA hydrolase activity
FORC23_RS11505	COG0012	GTP binding
FORC23_RS11620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC23_RS11625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC23_RS11630	COG1702	phosphate starvation-inducible protein PhoH
FORC23_RS11635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC23_RS11640	COG4535	Mg2 and Co2 transporter CorC
FORC23_RS11645	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC23_RS11650	COG2888	peptidyl-tyrosine sulfation
FORC23_RS11655	COG0495	leucyl-tRNA aminoacylation
FORC23_RS11660	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC23_RS11665	COG1466	dna polymerase III delta subunit
FORC23_RS11670	COG0799	negative regulation of ribosome biogenesis
FORC23_RS11675	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC23_RS11680	COG0768	penicillin binding
FORC23_RS11685	COG0772	Belongs to the SEDS family
FORC23_RS11690	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC23_RS11695	COG1686	Belongs to the peptidase S11 family
FORC23_RS11700	COG2921	Belongs to the UPF0250 family
FORC23_RS11705	COG0321	lipoyl(octanoyl) transferase activity
FORC23_RS11710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC23_RS11715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC23_RS11720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC23_RS11735	COG0366	Alpha amylase catalytic
FORC23_RS11740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC23_RS11740	COG1263	PTS System
FORC23_RS11750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC23_RS11755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC23_RS11760	COG2011	ABC-type metal ion transport system permease component
FORC23_RS11765	COG1464	Belongs to the NlpA lipoprotein family
FORC23_RS11770	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC23_RS11780	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC23_RS11780	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC23_RS11795	COG1611	Belongs to the LOG family
FORC23_RS11800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC23_RS11810	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC23_RS11815	COG2363	Small membrane protein
FORC23_RS11825	COG0583	DNA-binding transcription factor activity
FORC23_RS11830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC23_RS11830	COG0301	tRNA thio-modification
FORC23_RS11835	COG2885	chlorophyll binding
FORC23_RS11840	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC23_RS11845	COG1722	exodeoxyribonuclease VII activity
FORC23_RS11850	COG0142	geranyltranstransferase activity
FORC23_RS11855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC23_RS11860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC23_RS11865	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC23_RS11870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC23_RS11890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC23_RS11890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC23_RS11895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC23_RS11900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC23_RS11905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC23_RS11915	COG1073	alpha beta
FORC23_RS11920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC23_RS11925	COG2252	PERMEase
FORC23_RS11930	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC23_RS11955	COG0047	phosphoribosylformylglycinamidine synthase activity
FORC23_RS11955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC23_RS11960	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC23_RS11970	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC23_RS12000	COG0484	heat shock protein binding
FORC23_RS12005	COG0443	Heat shock 70 kDa protein
FORC23_RS12015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC23_RS12020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC23_RS12030	COG0497	DNA recombination
FORC23_RS12035	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC23_RS12040	COG2914	Belongs to the UPF0125 (RnfH) family
FORC23_RS12045	COG2867	negative regulation of translational initiation
FORC23_RS12050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC23_RS12065	COG0583	DNA-binding transcription factor activity
FORC23_RS12070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC23_RS12070	COG3153	acetyltransferase
FORC23_RS12090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC23_RS12095	COG2873	o-acetylhomoserine
FORC23_RS12125	COG1115	amino acid carrier protein
FORC23_RS12135	COG1584	GPR1 FUN34 yaaH family protein
FORC23_RS12145	COG1757	Na H antiporter
FORC23_RS12205	COG0582	viral genome integration into host DNA
FORC23_RS12210	COG0519	Catalyzes the synthesis of GMP from XMP
FORC23_RS12210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC23_RS12215	COG0516	GMP reductase activity
FORC23_RS12215	COG0517	IMP dehydrogenase activity
FORC23_RS12220	COG1570	exodeoxyribonuclease VII activity
FORC23_RS12235	COG1160	GTP binding
FORC23_RS12240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC23_RS12245	COG2976	Protein conserved in bacteria
FORC23_RS12250	COG0124	histidyl-tRNA synthetase
FORC23_RS12255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC23_RS12265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC23_RS12270	COG0105	UTP biosynthetic process
FORC23_RS12275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC23_RS12280	COG2975	iron-sulfur cluster assembly
FORC23_RS12285	COG0633	Ferredoxin
FORC23_RS12290	COG0443	Heat shock 70 kDa protein
FORC23_RS12295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC23_RS12305	COG0822	iron-sulfur transferase activity
FORC23_RS12310	COG1104	cysteine desulfurase activity
FORC23_RS12325	COG0483	inositol monophosphate 1-phosphatase activity
FORC23_RS12330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC23_RS12335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC23_RS12340	COG1862	Preprotein translocase
FORC23_RS12345	COG0343	queuine tRNA-ribosyltransferase activity
FORC23_RS12350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC23_RS12360	COG0517	IMP dehydrogenase activity
FORC23_RS12370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC23_RS12375	COG0583	DNA-binding transcription factor activity
FORC23_RS12380	COG0450	alkyl hydroperoxide reductase
FORC23_RS12385	COG3142	Participates in the control of copper homeostasis
FORC23_RS12395	COG0704	Plays a role in the regulation of phosphate uptake
FORC23_RS12400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC23_RS12405	COG0581	inorganic phosphate transmembrane transporter activity
FORC23_RS12415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC23_RS12420	COG0248	Ppx GppA phosphatase
FORC23_RS12430	COG5002	protein histidine kinase activity
FORC23_RS12435	COG0745	RESPONSE REGULATOR receiver
FORC23_RS12440	COG2974	May be involved in recombination
FORC23_RS12445	COG0826	peptidase U32
FORC23_RS12450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC23_RS12505	COG0542	response to heat
FORC23_RS12515	COG0564	pseudouridine synthase activity
FORC23_RS12520	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC23_RS12525	COG0741	lytic transglycosylase activity
FORC23_RS12530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC23_RS12535	COG0077	Prephenate dehydratase
FORC23_RS12535	COG1605	Chorismate mutase
FORC23_RS12540	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC23_RS12545	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC23_RS12555	COG0488	(ABC) transporter
FORC23_RS12565	COG0739	heme binding
FORC23_RS12570	COG0287	Prephenate dehydrogenase
FORC23_RS12570	COG1605	Chorismate mutase
FORC23_RS12575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC23_RS12580	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC23_RS12585	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC23_RS12590	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC23_RS12605	COG1966	Carbon starvation protein
FORC23_RS12610	COG3275	phosphorelay sensor kinase activity
FORC23_RS12615	COG3279	Response regulator of the LytR AlgR family
FORC23_RS12620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC23_RS12625	COG1047	Peptidyl-prolyl cis-trans
FORC23_RS12630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC23_RS12635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC23_RS12640	COG0196	riboflavin kinase activity
FORC23_RS12645	COG0728	peptidoglycan biosynthetic process
FORC23_RS12650	COG0268	Binds directly to 16S ribosomal RNA
FORC23_RS12655	COG0640	Transcriptional regulator
FORC23_RS12660	COG0583	DNA-binding transcription factor activity
FORC23_RS12665	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC23_RS12675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC23_RS12680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC23_RS12685	COG0730	response to heat
FORC23_RS12695	COG0494	nUDIX hydrolase
FORC23_RS12700	COG3066	DNA modification
FORC23_RS12710	COG0667	Aldo Keto reductase
FORC23_RS12720	COG2204	response regulator
FORC23_RS12725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC23_RS12730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC23_RS12735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC23_RS12740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC23_RS12745	COG4974	Belongs to the 'phage' integrase family
FORC23_RS12750	COG0716	FMN binding
FORC23_RS12760	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC23_RS12765	COG0513	Belongs to the DEAD box helicase family
FORC23_RS12770	COG3022	response to hydroperoxide
FORC23_RS12775	COG1115	amino acid carrier protein
FORC23_RS12790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC23_RS12795	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC23_RS12800	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC23_RS12805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC23_RS12810	COG0083	homoserine kinase activity
FORC23_RS12825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC23_RS12835	COG0745	RESPONSE REGULATOR receiver
FORC23_RS12845	COG5002	protein histidine kinase activity
FORC23_RS12845	COG0784	Response regulator, receiver
FORC23_RS12845	COG2198	Histidine kinase
FORC23_RS12850	COG3706	GGDEF domain
FORC23_RS12850	COG4251	negative regulation of phosphorylation
FORC23_RS12850	COG5001	Diguanylate cyclase
FORC23_RS12850	COG2203	Gaf domain
FORC23_RS12855	COG1242	4 iron, 4 sulfur cluster binding
FORC23_RS12860	COG0070	glutamate synthase
FORC23_RS12860	COG0069	glutamate synthase activity
FORC23_RS12860	COG0067	glutamate synthase
FORC23_RS12870	COG0069	glutamate synthase activity
FORC23_RS12870	COG0067	glutamate synthase
FORC23_RS12870	COG0070	glutamate synthase
FORC23_RS12875	COG0493	'glutamate synthase
FORC23_RS12885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC23_RS12895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC23_RS12900	COG2860	membrane
FORC23_RS12905	COG0583	DNA-binding transcription factor activity
FORC23_RS12910	COG0730	response to heat
FORC23_RS12925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC23_RS12930	COG0505	Belongs to the CarA family
FORC23_RS12935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC23_RS12940	COG0494	nUDIX hydrolase
FORC23_RS12945	COG0653	protein targeting
FORC23_RS12955	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORC23_RS12960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC23_RS12965	COG0849	cell division
FORC23_RS12970	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC23_RS12975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC23_RS12980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC23_RS12985	COG0772	Belongs to the SEDS family
FORC23_RS12990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC23_RS12995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC23_RS13000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC23_RS13005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC23_RS13010	COG0768	penicillin binding
FORC23_RS13015	COG3116	cell division
FORC23_RS13020	COG0275	rRNA processing
FORC23_RS13030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC23_RS13040	COG0792	nuclease activity
FORC23_RS13045	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC23_RS13050	COG2823	Periplasmic or secreted lipoprotein
FORC23_RS13055	COG2969	positive regulation of protein catabolic process
FORC23_RS13060	COG0625	glutathione transferase activity
FORC23_RS13065	COG2857	Cytochrome c1
FORC23_RS13070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC23_RS13075	COG0723	plastoquinol--plastocyanin reductase activity
FORC23_RS13080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC23_RS13085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC23_RS13090	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC23_RS13095	COG3105	Protein conserved in bacteria
FORC23_RS13105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC23_RS13110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC23_RS13120	COG3150	esterase
FORC23_RS13130	COG3151	Protein conserved in bacteria
FORC23_RS13135	COG0494	nUDIX hydrolase
FORC23_RS13140	COG1538	Outer membrane efflux protein
FORC23_RS13145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC23_RS13145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC23_RS13150	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC23_RS13165	COG3025	triphosphatase activity
FORC23_RS13170	COG1392	Phosphate transport regulator
FORC23_RS13175	COG0306	phosphate transporter
FORC23_RS13180	COG4991	sh3 domain protein
FORC23_RS13190	COG3267	Type II secretory pathway component ExeA
FORC23_RS13190	COG3409	Peptidoglycan-binding domain 1 protein
FORC23_RS13195	COG0617	tRNA 3'-terminal CCA addition
FORC23_RS13200	COG1968	undecaprenyl-diphosphatase activity
FORC23_RS13205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC23_RS13210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC23_RS13215	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC23_RS13220	COG0596	Alpha beta hydrolase
FORC23_RS13225	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC23_RS13230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC23_RS13235	COG1610	YqeY-like protein
FORC23_RS13240	COG0358	DNA primase activity
FORC23_RS13255	COG1464	Belongs to the NlpA lipoprotein family
FORC23_RS13285	COG2213	PTS system mannitol-specific
FORC23_RS13285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC23_RS13290	COG0246	Mannitol dehydrogenase
FORC23_RS13295	COG3722	fumarate hydratase activity
FORC23_RS13310	COG1461	Dihydroxyacetone kinase
FORC23_RS13315	COG2376	Dihydroxyacetone kinase
FORC23_RS13325	COG5002	protein histidine kinase activity
FORC23_RS13340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC23_RS13345	COG1349	DNA-binding transcription factor activity
FORC23_RS13350	COG0469	pyruvate kinase activity
FORC23_RS13365	COG0440	acetolactate synthase activity
FORC23_RS13370	COG0028	Belongs to the TPP enzyme family
FORC23_RS13375	COG1022	Amp-dependent synthetase and ligase
FORC23_RS13380	COG0583	DNA-binding transcription factor activity
FORC23_RS13400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC23_RS13405	COG0473	3-isopropylmalate dehydrogenase activity
FORC23_RS13410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC23_RS13415	COG0066	3-isopropylmalate dehydratase activity
FORC23_RS13425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC23_RS13430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC23_RS13435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC23_RS13440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC23_RS13445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC23_RS13450	COG2967	ApaG domain
FORC23_RS13455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC23_RS13470	COG2966	Psort location CytoplasmicMembrane, score
FORC23_RS13475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC23_RS13485	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC23_RS13490	COG0142	geranyltranstransferase activity
FORC23_RS13500	COG0039	L-malate dehydrogenase activity
FORC23_RS13510	COG2358	TRAP transporter, solute receptor (TAXI family
FORC23_RS13525	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC23_RS13530	COG1178	ABC-type Fe3 transport system permease component
FORC23_RS13535	COG4143	(ABC) transporter
FORC23_RS13540	COG0163	prenyltransferase activity
FORC23_RS13545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC23_RS13550	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC23_RS13555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC23_RS13565	COG2105	PFAM AIG2 family protein
FORC23_RS13575	COG0729	surface antigen
FORC23_RS13580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC23_RS13590	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC23_RS13605	COG4181	ATPase activity
FORC23_RS13625	COG0529	Catalyzes the synthesis of activated sulfate
FORC23_RS13630	COG0471	metal ion transport
FORC23_RS13630	COG3273	potassium ion transport
FORC23_RS13635	COG2895	sulfate adenylyltransferase (ATP) activity
FORC23_RS13640	COG0175	sulfate reduction
FORC23_RS13645	COG1648	precorrin-2 dehydrogenase activity
FORC23_RS13645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC23_RS13650	COG0737	Belongs to the 5'-nucleotidase family
FORC23_RS13660	COG0513	Belongs to the DEAD box helicase family
FORC23_RS13665	COG2153	protein acetylation
FORC23_RS13675	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC23_RS13685	COG0203	ribosomal protein L17
FORC23_RS13690	COG0202	RNA polymerase activity
FORC23_RS13700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC23_RS13705	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC23_RS13710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FORC23_RS13715	COG0201	protein transport
FORC23_RS13720	COG0200	Binds to the 23S rRNA
FORC23_RS13725	COG1841	ribosomal large subunit assembly
FORC23_RS13740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC23_RS13745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC23_RS13750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC23_RS13755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC23_RS13760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC23_RS13765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC23_RS13770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC23_RS13775	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC23_RS13785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC23_RS13790	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC23_RS13795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC23_RS13800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC23_RS13810	COG0088	Forms part of the polypeptide exit tunnel
FORC23_RS13815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC23_RS13825	COG0254	rRNA binding
FORC23_RS13830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC23_RS13835	COG1609	Transcriptional regulator
FORC23_RS13845	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC23_RS13850	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC23_RS13855	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC23_RS13860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC23_RS13865	COG3074	FtsZ-dependent cytokinesis
FORC23_RS13870	COG1494	fructose-1,6-bisphosphatase
FORC23_RS13895	COG0149	triose-phosphate isomerase activity
FORC23_RS13915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC23_RS13920	COG2030	dehydratase
FORC23_RS13930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC23_RS13950	COG1215	transferase activity, transferring glycosyl groups
FORC23_RS13955	COG0110	maltose O-acetyltransferase activity
FORC23_RS13965	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FORC23_RS13970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FORC23_RS13975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC23_RS13995	COG1086	Polysaccharide biosynthesis protein
FORC23_RS14020	COG0110	maltose O-acetyltransferase activity
FORC23_RS14065	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC23_RS14075	COG1560	Kdo2-lipid A biosynthetic process
FORC23_RS14080	COG0859	PFAM glycosyl transferase family 9
FORC23_RS14085	COG1519	Transferase
FORC23_RS14095	COG1083	cytidylyl-transferase
FORC23_RS14100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FORC23_RS14110	COG2089	acid synthase
FORC23_RS14115	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FORC23_RS14120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC23_RS14135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC23_RS14155	COG3642	lipopolysaccharide core region biosynthetic process
FORC23_RS14160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC23_RS14165	COG0859	PFAM glycosyl transferase family 9
FORC23_RS14170	COG0463	Glycosyl transferase, family 2
FORC23_RS14195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC23_RS14210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC23_RS14215	COG2003	Belongs to the UPF0758 family
FORC23_RS14220	COG0840	transmembrane signaling receptor activity
FORC23_RS14225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC23_RS14230	COG1309	transcriptional regulator
FORC23_RS14235	COG1560	Kdo2-lipid A biosynthetic process
FORC23_RS14240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC23_RS14245	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC23_RS14250	COG1561	YicC-like family, N-terminal region
FORC23_RS14260	COG4608	Belongs to the ABC transporter superfamily
FORC23_RS14265	COG0444	Belongs to the ABC transporter superfamily
FORC23_RS14270	COG0747	negative chemotaxis
FORC23_RS14275	COG4239	(ABC) transporter, permease
FORC23_RS14280	COG4174	ABC transporter (Permease)
FORC23_RS14300	COG0811	peptide transport
FORC23_RS14305	COG0848	biopolymer transport protein
FORC23_RS14320	COG0194	GDP metabolic process
FORC23_RS14325	COG1758	RNA polymerase activity
FORC23_RS14330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC23_RS14335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC23_RS14340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC23_RS14350	COG2233	PERMEase
FORC23_RS14370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC23_RS14380	COG2183	response to ionizing radiation
FORC23_RS14390	COG0596	Alpha beta hydrolase
FORC23_RS14395	COG1040	competence protein
FORC23_RS14400	COG0316	Belongs to the HesB IscA family
FORC23_RS14400	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC23_RS14405	COG0494	nUDIX hydrolase
FORC23_RS14410	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC23_RS14420	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC23_RS14425	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC23_RS14430	COG3156	type II secretion system protein K
FORC23_RS14435	COG4795	General secretion pathway protein
FORC23_RS14440	COG2165	general secretion pathway protein
FORC23_RS14445	COG2165	general secretion pathway protein
FORC23_RS14450	COG2165	general secretion pathway protein
FORC23_RS14455	COG1459	type II secretion system
FORC23_RS14460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC23_RS14470	COG3031	protein transport across the cell outer membrane
FORC23_RS14475	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC23_RS14480	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC23_RS14485	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC23_RS14495	COG0456	acetyltransferase
FORC23_RS14500	COG1490	D-aminoacyl-tRNA deacylase activity
FORC23_RS14505	COG1295	ribonuclease BN
FORC23_RS14520	COG1217	gtp-binding protein TYPA
FORC23_RS14525	COG0174	glutamine synthetase
FORC23_RS14535	COG3852	Histidine kinase
FORC23_RS14540	COG2204	response regulator
FORC23_RS14550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC23_RS14580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC23_RS14585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC23_RS14585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC23_RS14600	COG0084	hydrolase, TatD family'
FORC23_RS14605	COG0805	protein transport
FORC23_RS14610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC23_RS14615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC23_RS14620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC23_RS14625	COG3165	ubiquinone biosynthetic process from chorismate
FORC23_RS14630	COG2226	methyltransferase
FORC23_RS14635	COG1322	Protein conserved in bacteria
FORC23_RS14650	COG0628	permease
FORC23_RS14700	COG2823	Periplasmic or secreted lipoprotein
FORC23_RS14710	COG2081	HI0933 family
FORC23_RS14720	COG1528	Iron-storage protein
FORC23_RS14725	COG0589	response to stress
FORC23_RS14740	COG0742	ribosomal rna small subunit methyltransferase
FORC23_RS14745	COG5001	Diguanylate cyclase
FORC23_RS14745	COG5002	protein histidine kinase activity
FORC23_RS14750	COG1522	sequence-specific DNA binding
FORC23_RS14755	COG0339	signal peptide processing
FORC23_RS14760	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC23_RS14765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC23_RS14770	COG0583	DNA-binding transcription factor activity
FORC23_RS14775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC23_RS14780	COG0800	Aldolase
FORC23_RS14785	COG2610	gluconate transmembrane transporter activity
FORC23_RS14790	COG3265	gluconokinase activity
FORC23_RS14795	COG0129	dihydroxy-acid dehydratase activity
FORC23_RS14810	COG0583	DNA-binding transcription factor activity
FORC23_RS14815	COG1609	Transcriptional regulator
FORC23_RS14850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC23_RS14855	COG0601	transmembrane transport
FORC23_RS14860	COG0747	negative chemotaxis
FORC23_RS14865	COG4172	Belongs to the ABC transporter superfamily
FORC23_RS14920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC23_RS14925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC23_RS14930	COG2960	long-chain fatty acid transporting porin activity
FORC23_RS14935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC23_RS14940	COG0583	DNA-binding transcription factor activity
FORC23_RS14980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC23_RS14985	COG1739	Uncharacterized protein family UPF0029
FORC23_RS14990	COG1024	Enoyl-CoA hydratase
FORC23_RS14990	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC23_RS14995	COG0183	Belongs to the thiolase family
FORC23_RS15000	COG0604	alcohol dehydrogenase
FORC23_RS15015	COG0425	Belongs to the sulfur carrier protein TusA family
FORC23_RS15025	COG2119	membrane
FORC23_RS15030	COG0752	glycyl-tRNA synthetase alpha subunit
FORC23_RS15035	COG0751	glycine-tRNA ligase activity
FORC23_RS15040	COG0366	Alpha amylase catalytic
FORC23_RS15045	COG3977	Valine--pyruvate aminotransferase
FORC23_RS15050	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC23_RS15060	COG0187	DNA topoisomerase II activity
FORC23_RS15065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC23_RS15070	COG0592	DNA-directed DNA polymerase activity
FORC23_RS15165	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FORC23_RS15240	COG1192	Involved in chromosome partitioning
FORC23_RS15275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC23_RS15570	COG0352	thiamine-phosphate diphosphorylase activity
FORC23_RS15850	COG2199	diguanylate cyclase activity
FORC23_RS15850	COG3287	FIST C domain
FORC23_RS15850	COG2200	EAL domain
FORC23_RS16390	COG2198	Histidine kinase
FORC23_RS16390	COG0784	Response regulator, receiver
FORC23_RS16390	COG2205	protein histidine kinase activity
FORC23_RS16520	COG1509	lysine 2,3-aminomutase activity
FORC23_RS16560	COG1053	succinate dehydrogenase
FORC23_RS16675	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC23_RS16710	COG0330	HflC and HflK could
FORC23_RS16745	COG0557	exoribonuclease II activity
FORC23_RS16875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC23_RS16925	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC23_RS17085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC23_RS17420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC23_RS17760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC23_RS17800	COG0191	fructose-bisphosphate aldolase activity
FORC23_RS17890	COG0481	GTPase activity
FORC23_RS17925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC23_RS18015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC23_RS18455	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC23_RS18460	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC23_RS18570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC23_RS18700	COG3250	beta-galactosidase activity
FORC23_RS18825	COG3083	sulfuric ester hydrolase activity
FORC23_RS19180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC23_RS19270	COG4783	chaperone-mediated protein folding
FORC23_RS19300	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FORC23_RS19500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC23_RS19715	COG0814	amino acid
FORC23_RS19720	COG0814	amino acid
FORC23_RS19750	COG1785	Belongs to the alkaline phosphatase family
FORC23_RS19880	COG1757	Na H antiporter
FORC23_RS20005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC23_RS20135	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC23_RS20250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC23_RS20585	COG5002	protein histidine kinase activity
FORC23_RS20585	COG3850	Histidine kinase
FORC23_RS22605	COG0534	Mate efflux family protein
FORC23_RS22740	COG3302	dmso reductase anchor subunit