locus-tag class description FDP11_RS00015 ENOG4105C8U phosphate abc transporter FDP11_RS00020 ENOG4105E2Z phosphate ABC transporter (Permease FDP11_RS00025 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS00060 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FDP11_RS00065 ENOG41069D7 Methyl-accepting chemotaxis FDP11_RS00075 ENOG41086KC Transcriptional regulator FDP11_RS00080 ENOG41086KC Transcriptional regulator FDP11_RS00090 ENOG4108JJ6 Type I secretion system ATPase FDP11_RS00105 ENOG4105S6R Iron-hydroxamate transporter permease subunit FDP11_RS00110 ENOG4108HUF Transporter FDP11_RS00115 ENOG4105E0A ABC, transporter FDP11_RS00120 ENOG4105E0K tonB-dependent siderophore receptor FDP11_RS00125 ENOG4105BZ1 (ABC) transporter FDP11_RS00145 ENOG4105CZN Potassium uptake protein FDP11_RS00150 ENOG4105BZU Histidine kinase FDP11_RS00160 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 FDP11_RS00170 ENOG4105EIP mannose-6-phosphate isomerase FDP11_RS00175 ENOG4105DM4 PTS System FDP11_RS00180 ENOG4106R3P AraC family transcriptional regulator FDP11_RS00190 ENOG4108YRF PTS System FDP11_RS00195 ENOG4105DM4 PTS System FDP11_RS00200 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FDP11_RS00205 ENOG4105CH6 catalase FDP11_RS00210 ENOG4108RXX maleylacetoacetate isomerase FDP11_RS00215 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FDP11_RS00220 ENOG4108WUH Transcriptional regulator, TetR family FDP11_RS00225 ENOG4105V0I UPF0267 protein FDP11_RS00255 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FDP11_RS00265 ENOG4105D75 Capsular exopolysaccharide family FDP11_RS00280 ENOG4105D3Q Sugar transferase FDP11_RS00285 ENOG4108IJ9 (ABC) transporter FDP11_RS00290 ENOG4107FKK extracellular solute-binding protein family 1 FDP11_RS00295 ENOG4105D56 permease protein FDP11_RS00300 ENOG4105EG2 ABC transporter, permease FDP11_RS00330 ENOG4105CKW Inner membrane protein yedI FDP11_RS00335 ENOG4105EKE dihydroorotase FDP11_RS00345 ENOG4105QVC MOSC domain-containing protein FDP11_RS00345 ENOG4105QVC MOSC domain-containing protein FDP11_RS00350 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FDP11_RS00355 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FDP11_RS00395 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS00400 ENOG4105EHG Permease protein FDP11_RS00410 ENOG4106GFD transport protein FDP11_RS00415 ENOG41090AP transport protein FDP11_RS00420 ENOG4105WQ5 TonB family FDP11_RS00425 ENOG4105D4P Coproporphyrinogen iii oxidase FDP11_RS00430 ENOG41090JE Utilization Protein FDP11_RS00435 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related FDP11_RS00450 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FDP11_RS00460 ENOG4105G2Y Transcriptional regulator FDP11_RS00465 ENOG4105CNH Multidrug resistance protein MdtL FDP11_RS00475 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FDP11_RS00515 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FDP11_RS00525 ENOG4105C5Q Transcriptional regulator FDP11_RS00545 ENOG4105KXC Collagenase FDP11_RS00570 ENOG4105CKD glutathione-regulated potassium-efflux system protein FDP11_RS00575 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FDP11_RS00580 ENOG4108M6U Universal stress protein A FDP11_RS00585 ENOG4105C5H ABC transporter FDP11_RS00600 ENOG4105ENT Efflux transporter rnd family, mfp subunit FDP11_RS00610 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FDP11_RS00620 ENOG4108HK0 -acetyltransferase FDP11_RS00630 ENOG410620I Diguanylate cyclase FDP11_RS00650 ENOG4108IJF Heavy metal efflux pump, CzcA FDP11_RS00670 ENOG4108IEG Formate dehydrogenase Alpha subunit FDP11_RS00685 ENOG4107QWP ABC-2 type transporter FDP11_RS00690 ENOG4105CJ1 ABC, transporter FDP11_RS00700 ENOG4108NVR Methyl-accepting chemotaxis FDP11_RS00705 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FDP11_RS00710 ENOG4105JAB phenazine biosynthesis protein, phzf family FDP11_RS00715 ENOG4108V1U phospholipid-binding protein FDP11_RS00725 ENOG4105D6J arsenicaL-resistance protein FDP11_RS00740 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FDP11_RS00745 ENOG4105CTS PTS system mannitol-specific FDP11_RS00750 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FDP11_RS00760 ENOG4107Z1W Fructose transport system kinase FDP11_RS00785 ENOG4105E0U tyrosine-specific transport protein FDP11_RS00795 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS00800 ENOG4105DWD nucleoside recognition domain protein FDP11_RS00820 ENOG4105DR5 peptidase FDP11_RS00830 ENOG4105CR8 Transcriptional regulator FDP11_RS00835 ENOG4105E5M Multidrug resistance protein D FDP11_RS00845 ENOG4105VW4 glutaredoxin 3 FDP11_RS00850 ENOG4108SXK Transporter Drug Metabolite Exporter family FDP11_RS00880 ENOG4105SUT Transcriptional Regulator AraC Family FDP11_RS00885 ENOG4105CCF Lysine exporter protein (Lyse ygga) FDP11_RS00910 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) FDP11_RS00915 ENOG4107QS1 Cytochrome C Oxidase, Subunit III FDP11_RS00935 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FDP11_RS00940 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FDP11_RS00945 ENOG4108V1T peptidylprolyl cis-trans isomerase FDP11_RS00975 ENOG4105VEQ Cold shock protein FDP11_RS00985 ENOG4107SDU Methyl-accepting chemotaxis FDP11_RS00990 ENOG4105BZU Histidine kinase FDP11_RS01010 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FDP11_RS01020 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS01025 ENOG4108RMU ferritin dps family protein FDP11_RS01040 ENOG4105C0A alcohol dehydrogenase FDP11_RS01045 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FDP11_RS01085 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FDP11_RS01090 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FDP11_RS01095 ENOG4105MIR Phenylalanine 4-monooxygenase FDP11_RS01100 ENOG41090A4 Pterin carbinolamine dehydratase FDP11_RS01120 ENOG4105VRT cytoplasmic protein FDP11_RS01125 ENOG4105C1J atp-dependent rna helicase FDP11_RS01130 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FDP11_RS01135 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FDP11_RS01145 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FDP11_RS01155 ENOG4105CKI cobalamin synthesis protein FDP11_RS01160 ENOG4105C1J atp-dependent rna helicase FDP11_RS01180 ENOG4105CXC rtn protein FDP11_RS01185 ENOG4105DKW ABC transporter FDP11_RS01190 ENOG4108N3W hemolysin secretion protein FDP11_RS01200 ENOG4105DUM transcriptional regulator, lysR family FDP11_RS01205 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FDP11_RS01210 ENOG4105C4X radical SAM domain protein FDP11_RS01230 ENOG4107S17 Phosphate-binding protein FDP11_RS01245 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) FDP11_RS01250 ENOG4105C1J atp-dependent rna helicase FDP11_RS01255 ENOG4105BZU Histidine kinase FDP11_RS01260 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FDP11_RS01265 ENOG4107SDU Methyl-accepting chemotaxis FDP11_RS01280 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FDP11_RS01285 ENOG4105CGU Enoyl-CoA hydratase FDP11_RS01290 ENOG4107QX3 carboxylase FDP11_RS01295 ENOG4105C1G acyl-Coa dehydrogenase FDP11_RS01305 ENOG4105CHU acetyl-coa acetyltransferase FDP11_RS01310 ENOG4105C26 Dehydrogenase FDP11_RS01320 ENOG4105E39 Enoyl-CoA hydratase FDP11_RS01325 ENOG4105E39 Enoyl-CoA hydratase FDP11_RS01330 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FDP11_RS01335 ENOG4105CHR reductase FDP11_RS01340 ENOG4105E2S oxidase) subunit II FDP11_RS01345 ENOG4105BZ9 Cytochrome C oxidase, subunit I FDP11_RS01350 ENOG4105CCU oxidase (Subunit III) FDP11_RS01360 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FDP11_RS01375 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDP11_RS01385 ENOG4105E5Z arginine transporter ATP-binding subunit FDP11_RS01390 ENOG4106PMH Extracellular solute-binding protein family 3 FDP11_RS01395 ENOG4105GBT ABC transporter FDP11_RS01400 ENOG4105DMR ABC, transporter FDP11_RS01410 ENOG4105DUM transcriptional regulator, lysR family FDP11_RS01415 ENOG4107MKT Stringent starvation protein a FDP11_RS01420 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FDP11_RS01425 ENOG4107QSN dihydrolipoamide acetyltransferase FDP11_RS01430 ENOG4105CPP Dehydrogenase, E1 component FDP11_RS01435 ENOG4107RUY (E1 component), alpha subunit FDP11_RS01450 ENOG4105R8A Heat shock protein FDP11_RS01455 ENOG4106E5D Protein of unknown function (DUF461) FDP11_RS01480 ENOG4105ETX regulatoR FDP11_RS01495 ENOG4105G6Z alkaline phosphatase FDP11_RS01520 ENOG4105C44 Serine transporter FDP11_RS01535 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FDP11_RS01560 ENOG4105DG7 nitrate ABC transporter FDP11_RS01565 ENOG4105D7T ABC transporter FDP11_RS01570 ENOG4107QZF nitrite reductase NADPH large subunit FDP11_RS01585 ENOG4108IG5 Transcriptional regulator FDP11_RS01600 ENOG4105F8J Adenylate Guanylate cyclase FDP11_RS01625 ENOG4105D9P serine threonine protein kinase FDP11_RS01645 ENOG4106VK6 Flagellar motor protein FDP11_RS01660 ENOG4108ZF3 Phosphatase FDP11_RS01705 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FDP11_RS01735 ENOG4105EYH Exonuclease FDP11_RS01755 ENOG4105QNF Outer membrane lipoprotein FDP11_RS01765 ENOG4105C2C drug resistance transporter, Bcr CflA FDP11_RS01780 ENOG4108MGY Histidine kinase FDP11_RS01785 ENOG4107KBT 8-Amino-7-oxononanoate synthase FDP11_RS01790 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FDP11_RS01800 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FDP11_RS01805 ENOG4105C4X radical SAM domain protein FDP11_RS01840 ENOG4108YGG dna repair protein FDP11_RS01855 ENOG4106YYS transcriptional regulatory protein FDP11_RS01860 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FDP11_RS01865 ENOG4105D9Q decarboxylase (Beta subunit) FDP11_RS01870 ENOG4107QSA Oxaloacetate decarboxylase FDP11_RS01885 ENOG4105DUA (citrate (pro-3S)-lyase ligase FDP11_RS01895 ENOG4105CI0 Citrate lyase FDP11_RS01900 ENOG4105CHY citrate lyase, alpha FDP11_RS01910 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FDP11_RS01975 ENOG4105C0A alcohol dehydrogenase FDP11_RS01980 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) FDP11_RS01985 ENOG4105DKG l-rhamnose isomerase FDP11_RS01990 ENOG4105DET Rhamnulokinase FDP11_RS01995 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) FDP11_RS02045 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS02055 ENOG4107RK6 Methyl-accepting chemotaxis FDP11_RS02060 ENOG4108M8H domain protein FDP11_RS02070 ENOG4108M3R transcriptional activator CadC FDP11_RS02115 ENOG4107HQ7 repeat protein FDP11_RS02120 ENOG4107QNK )-transporter FDP11_RS02130 ENOG4108NZE NAGC-like transcriptional regulator FDP11_RS02135 ENOG4105CGH 5'-nucleotidase FDP11_RS02155 ENOG4106H3A restriction FDP11_RS02160 ENOG4107SCJ type I restriction enzyme EcoKI subunit R FDP11_RS02165 ENOG4107QTH restriction modification system DNA specificity domain FDP11_RS02180 ENOG4105CVR type I restriction-modification system FDP11_RS02200 ENOG41064T2 transcriptional regulator, lysR family FDP11_RS02210 ENOG4105BZU Histidine kinase FDP11_RS02215 ENOG4105BZU Histidine kinase FDP11_RS02220 ENOG4108WQH regulatoR FDP11_RS02225 ENOG4105BZU Histidine kinase FDP11_RS02235 ENOG4108WQH regulatoR FDP11_RS02255 ENOG4107R88 Chemotaxis protein (CheV) FDP11_RS02270 ENOG4105FR1 rard protein FDP11_RS02280 ENOG4106CKV Pap2 superfamily protein FDP11_RS02290 ENOG4105CSX c4-dicarboxylate anaerobic carrier FDP11_RS02295 ENOG4106RE7 Cytochrome FDP11_RS02300 ENOG4105C5W Aldolase FDP11_RS02310 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) FDP11_RS02315 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FDP11_RS02330 ENOG4105CC0 LysR family Transcriptional regulator FDP11_RS02335 ENOG4105CXG d-lactate dehydrogenase FDP11_RS02350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FDP11_RS02355 ENOG4108NVR Methyl-accepting chemotaxis FDP11_RS02390 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FDP11_RS02425 ENOG4105NXH GreA GreB family elongation factor FDP11_RS02430 ENOG4107QZF nitrite reductase NADPH large subunit FDP11_RS02435 ENOG4105WZK nitrite reductase NADPH small subunit FDP11_RS02440 ENOG4105TMB Formate nitrite transporter FDP11_RS02445 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FDP11_RS02460 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FDP11_RS02485 ENOG4105VXR cytoplasmic protein FDP11_RS02505 ENOG4105K63 Thioredoxin FDP11_RS02510 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FDP11_RS02530 ENOG4105EIP mannose-6-phosphate isomerase FDP11_RS02535 ENOG4105CXY transporter FDP11_RS02540 ENOG4105BZU Histidine kinase FDP11_RS02545 ENOG4108KX4 response regulator FDP11_RS02550 ENOG4105CXY transporter FDP11_RS02555 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FDP11_RS02560 ENOG4105C5Q Transcriptional regulator FDP11_RS02565 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FDP11_RS02595 ENOG4105BZS acriflavin resistance protein FDP11_RS02610 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FDP11_RS02650 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FDP11_RS02720 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FDP11_RS02730 ENOG4107QI1 Mate efflux family protein FDP11_RS02735 ENOG4105ECQ AraC Family Transcriptional Regulator FDP11_RS02740 ENOG4105CGF Aromatic amino acid aminotransferase FDP11_RS02745 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FDP11_RS02755 ENOG4105WXI Bacterial OB fold (BOF) protein FDP11_RS02760 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FDP11_RS02765 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FDP11_RS02770 ENOG4105E0C molybdate abc transporter FDP11_RS02775 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS02810 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FDP11_RS02815 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FDP11_RS02845 ENOG4108M6U Universal stress protein A FDP11_RS02855 ENOG4105EJC lysr family transcriptional regulator FDP11_RS02870 ENOG4108ZJT translation initiation factor, Sui1 FDP11_RS02880 ENOG4105CPF Cell wall formation (By similarity) FDP11_RS02890 ENOG4105CD5 CoA-binding domain protein FDP11_RS02895 ENOG4105CWB LysR family transcriptional Regulator FDP11_RS02905 ENOG4105CMR udp-glucose 4-epimerase FDP11_RS02910 ENOG4105BZU Histidine kinase FDP11_RS02915 ENOG4105E7W lamb ycsf family protein FDP11_RS02920 ENOG4105P4J Allophanate hydrolase, subunit 1 FDP11_RS02925 ENOG4107R7A Allophanate hydrolase subunit 2 FDP11_RS02935 ENOG4105CV6 ABC transporter, permease FDP11_RS02940 ENOG4108I0Y (ABC) transporter FDP11_RS02950 ENOG4105RKW reductase (By FDP11_RS02955 ENOG4105BZU Histidine kinase FDP11_RS02965 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FDP11_RS02990 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FDP11_RS03000 ENOG4105KA0 thioesterase Superfamily protein FDP11_RS03015 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FDP11_RS03020 ENOG4108M0H Extracellular lipase FDP11_RS03035 ENOG4105DU1 integral membrane protein, terc FDP11_RS03040 ENOG4105CGH 5'-nucleotidase FDP11_RS03045 ENOG4105CPB ATP-dependent endonuclease of the OLD family FDP11_RS03050 ENOG4108UQ5 membrane protein YcdZ FDP11_RS03055 ENOG4105DUM transcriptional regulator, lysR family FDP11_RS03060 ENOG4105TMB Formate nitrite transporter FDP11_RS03065 ENOG4108YYC ycei family FDP11_RS03070 ENOG4105DS1 cytochrome b561 FDP11_RS03085 ENOG4108M8H domain protein FDP11_RS03090 ENOG4105C1J atp-dependent rna helicase FDP11_RS03095 ENOG4108ZYK Acyl carrier protein phosphodiesterase FDP11_RS03105 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FDP11_RS03110 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FDP11_RS03125 ENOG4107RE1 Inosine-guanosine kinase FDP11_RS03130 ENOG4105CKU formyltetrahydrofolate synthetase FDP11_RS03135 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FDP11_RS03145 ENOG4105CF7 AraC family transcriptional regulator FDP11_RS03150 ENOG4108I6A alcohol dehydrogenase FDP11_RS03160 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta FDP11_RS03170 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FDP11_RS03175 ENOG4105CXY transporter FDP11_RS03180 ENOG4105CA9 Pyruvate kinase FDP11_RS03185 ENOG4105CDA abc transporter atp-binding protein FDP11_RS03190 ENOG4105E5Q amino acid AbC transporter FDP11_RS03195 ENOG4106TNF Periplasmic binding protein FDP11_RS03200 ENOG4105E5Q amino acid AbC transporter FDP11_RS03205 ENOG4108NJZ Sensory box GGDEF EAL domain protein FDP11_RS03220 ENOG4107B7Y DNA-binding transcriptional regulator FruR FDP11_RS03225 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FDP11_RS03230 ENOG4105DE4 1-phosphofructokinase FDP11_RS03235 ENOG4105DM4 PTS System FDP11_RS03275 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FDP11_RS03280 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FDP11_RS03285 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FDP11_RS03330 ENOG4105CR8 Transcriptional regulator FDP11_RS03335 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FDP11_RS03365 ENOG4105HDD phospholipase FDP11_RS03380 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FDP11_RS03420 ENOG4105CJW magnesium transporter FDP11_RS03440 ENOG4108UYE Lactoylglutathione lyase FDP11_RS03445 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDP11_RS03470 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FDP11_RS03485 ENOG4106YYS transcriptional regulatory protein FDP11_RS03490 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FDP11_RS03495 ENOG4107QPK )-transporter FDP11_RS03500 ENOG4107RGH Aldehyde dehydrogenase FDP11_RS03520 ENOG4108I0N Transporter, RarD family, DMT superfamily protein FDP11_RS03555 ENOG4105CEE C4-dicarboxylate transporter FDP11_RS03560 ENOG4108V0P LemA family FDP11_RS03565 ENOG4105D0M Protease HtpX homolog FDP11_RS03580 ENOG4105F2V VRR-NUC domain-containing protein FDP11_RS03590 ENOG4105C4X radical SAM domain protein FDP11_RS03605 ENOG4108YDI single-species biofilm formation on inanimate substrate FDP11_RS03610 ENOG4107TE5 Lipid kinase FDP11_RS03615 ENOG41064T2 transcriptional regulator, lysR family FDP11_RS03620 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FDP11_RS03650 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FDP11_RS03655 ENOG4105C4X radical SAM domain protein FDP11_RS03660 ENOG4105ENH Sulfatase FDP11_RS03675 ENOG4105ENH Sulfatase FDP11_RS03680 ENOG41061MV Arylsulfatase FDP11_RS03685 ENOG4105E3W Two component transcriptional regulator (Winged helix family FDP11_RS03700 ENOG4105BZU Histidine kinase FDP11_RS03705 ENOG4108SV3 Tmao reductase system periplasmic protein tort FDP11_RS03710 ENOG4108Z5K methylglyoxal synthase FDP11_RS03715 ENOG41088T4 Helicase IV FDP11_RS03720 ENOG4105EM2 membrane FDP11_RS03760 ENOG4108Z6Z Transcriptional regulator FDP11_RS03765 ENOG4108IPW abc transporter atp-binding protein FDP11_RS03770 ENOG4105CM4 permease protein FDP11_RS03775 ENOG4105DHS permease protein FDP11_RS03790 ENOG4108I5U Uridine phosphorylase FDP11_RS03795 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FDP11_RS03805 ENOG4105ETE Transcriptional regulator (LacI family FDP11_RS03810 ENOG4108RVA ribokinase FDP11_RS03815 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FDP11_RS03820 ENOG4105CNN ABC, transporter FDP11_RS03825 ENOG4105C2J ABC transporter FDP11_RS03830 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FDP11_RS03835 ENOG4108K0B C-di-gmp phosphodiesterase FDP11_RS03840 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FDP11_RS03895 ENOG4105BZU Histidine kinase FDP11_RS03900 ENOG4105CA0 peroxidase FDP11_RS03905 ENOG4105BZU Histidine kinase FDP11_RS03915 ENOG4107QX8 SPFH domain, Band 7 family protein FDP11_RS03925 ENOG4108RCM Nitroreductase FDP11_RS03930 ENOG4108IJ7 Glycine betaine FDP11_RS03935 ENOG4108HQS Glycine betaine FDP11_RS03945 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FDP11_RS03950 ENOG4105C26 Dehydrogenase FDP11_RS03955 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FDP11_RS03960 ENOG4105BZU Histidine kinase FDP11_RS03970 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FDP11_RS03980 ENOG4105E39 Enoyl-CoA hydratase FDP11_RS03985 ENOG4105C1G acyl-Coa dehydrogenase FDP11_RS03990 ENOG4105C26 Dehydrogenase FDP11_RS03995 ENOG4105CHU acetyl-coa acetyltransferase FDP11_RS04005 ENOG4105C1G acyl-Coa dehydrogenase FDP11_RS04010 ENOG4107QX3 carboxylase FDP11_RS04015 ENOG4108IPT Naphthoate synthase FDP11_RS04025 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FDP11_RS04030 ENOG4105BZU Histidine kinase FDP11_RS04045 ENOG4105EGS Mechanosensitive ion channel FDP11_RS04050 ENOG4108UW5 maltose o-acetyltransferase FDP11_RS04055 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDP11_RS04060 ENOG4105C4M (Ubiquinol oxidase) subunit I FDP11_RS04065 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FDP11_RS04075 ENOG4108S58 Phenazine biosynthesis protein PhzF FDP11_RS04080 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FDP11_RS04085 ENOG4105VUF Transcriptional regulator FDP11_RS04095 ENOG4105G9V cytochrome C FDP11_RS04110 ENOG4105DZS Phenylacetate-CoA ligase FDP11_RS04115 ENOG4108IV0 ABC, transporter FDP11_RS04140 ENOG4105C0Z ABC transporter FDP11_RS04145 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FDP11_RS04150 ENOG4105BZJ Electron transfer flavoprotein FDP11_RS04155 ENOG4105C10 Electron transfer flavoprotein FDP11_RS04160 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FDP11_RS04165 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FDP11_RS04170 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FDP11_RS04180 ENOG4108UNF response regulator FDP11_RS04185 ENOG4107RGM aldo keto reductase FDP11_RS04200 ENOG4105CMQ Chloride channel FDP11_RS04210 ENOG4105C5A transporter FDP11_RS04220 ENOG4105CVM Molybdenum cofactor synthesis domain protein FDP11_RS04225 ENOG4105D06 uba thif-type nad fad binding protein FDP11_RS04245 ENOG4105KHC sulfurtransferase FDP11_RS04250 ENOG4105BZU Histidine kinase FDP11_RS04265 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FDP11_RS04270 ENOG4105CV1 Transketolase (EC 2.2.1.1) FDP11_RS04275 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FDP11_RS04280 ENOG4105DXI Major Facilitator superfamily FDP11_RS04285 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FDP11_RS04290 ENOG4105UYK outer membrane protein a FDP11_RS04295 ENOG4107VXZ Hydrolase FDP11_RS04300 ENOG4108YZN class I peptide chain release factor FDP11_RS04305 ENOG4108N3W hemolysin secretion protein FDP11_RS04320 ENOG4107YWA deoxycytidylate deaminase FDP11_RS04325 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FDP11_RS04340 ENOG4105WH1 Two component transcriptional regulator luxr family FDP11_RS04345 ENOG4105BZU Histidine kinase FDP11_RS04360 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FDP11_RS04370 ENOG4105CUW cytochrome C-TYPE protein FDP11_RS04380 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FDP11_RS04390 ENOG4105CHU acetyl-coa acetyltransferase FDP11_RS04410 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FDP11_RS04415 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FDP11_RS04460 ENOG4105EFX secretion protein, HlyD family FDP11_RS04470 ENOG4105BZU Histidine kinase FDP11_RS04475 ENOG4108QGH periplasmic FDP11_RS04480 ENOG41082IR Excinuclease ABC C subunit domain protein FDP11_RS04485 ENOG4108YXG UPF0502 protein FDP11_RS04495 ENOG41090HJ UPF0265 protein FDP11_RS04505 ENOG4105EE0 oxidoreductase FDP11_RS04510 ENOG4105BZU Histidine kinase FDP11_RS04530 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FDP11_RS04535 ENOG4108XM1 transcriptional regulator AsnC family FDP11_RS04540 ENOG4105DVH amino acid FDP11_RS04555 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FDP11_RS04560 ENOG4105CJW magnesium transporter FDP11_RS04565 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FDP11_RS04570 ENOG4105DZC cytosine deaminase FDP11_RS04580 ENOG4105EST Metal Dependent Phosphohydrolase FDP11_RS04590 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FDP11_RS04600 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FDP11_RS04620 ENOG4108Z33 Thiol disulfide Interchange Protein FDP11_RS04635 ENOG4105EMU Dehydrogenase FDP11_RS04640 ENOG4107EXC regulatoR FDP11_RS04645 ENOG4105JJR Histidine kinase FDP11_RS04655 ENOG41080IJ Diacylglycerol kinase FDP11_RS04660 ENOG4105DIJ Phosphoethanolamine transferase FDP11_RS04665 ENOG4105EP9 oxidoreductase FDP11_RS04690 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FDP11_RS04700 ENOG4108NRW Phospholipase, patatin family FDP11_RS04705 ENOG4105EUB pirin domain protein FDP11_RS04710 ENOG4105VEQ Cold shock protein FDP11_RS04725 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FDP11_RS04745 ENOG4105DZ1 carboxypeptidase FDP11_RS04750 ENOG4105CYM Glutathione S-transferase FDP11_RS04760 ENOG4105NAE bifunctional deaminase-reductase domain protein FDP11_RS04780 ENOG4105CHR reductase FDP11_RS04795 ENOG4108P3C FDP11_RS04815 ENOG410874W AraC family transcriptional regulator FDP11_RS04820 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDP11_RS04845 ENOG4105C1J atp-dependent rna helicase FDP11_RS04855 ENOG4107RSM transcriptional regulator FDP11_RS04870 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDP11_RS04875 ENOG4105CPQ Dehydrogenase FDP11_RS04885 ENOG4105CHR reductase FDP11_RS04890 ENOG4108ZX5 transcriptional regulator FDP11_RS04895 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FDP11_RS04915 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FDP11_RS04920 ENOG4105HDK L-asparaginase FDP11_RS04925 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FDP11_RS04930 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FDP11_RS04945 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FDP11_RS04950 ENOG4108HM4 ABC transporter FDP11_RS04965 ENOG4107KET secretion protein, HlyD family FDP11_RS04985 ENOG4105BZU Histidine kinase FDP11_RS04995 ENOG41086KC Transcriptional regulator FDP11_RS05035 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS05085 ENOG4107RZC phospholipase d FDP11_RS05110 ENOG4108Z4X TRANSCRIPTIONal FDP11_RS05120 ENOG4105RQF LysR family Transcriptional regulator FDP11_RS05130 ENOG4107S8C mandelate racemase muconate lactonizing FDP11_RS05135 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FDP11_RS05160 ENOG4105VYW UPF0251 protein FDP11_RS05165 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FDP11_RS05170 ENOG4105RW8 MltA-interacting MipA family protein FDP11_RS05185 ENOG4105ETT transcriptional Regulator, LysR family FDP11_RS05210 ENOG4107RH7 Nicotinate phosphoribosyltransferase FDP11_RS05220 ENOG4108RWI nicotinamidase FDP11_RS05230 ENOG4105CH6 catalase FDP11_RS05240 ENOG4105N2W Transcriptional regulator FDP11_RS05245 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FDP11_RS05250 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FDP11_RS05260 ENOG4105DM4 PTS System FDP11_RS05265 ENOG4105DM4 PTS System FDP11_RS05270 ENOG4105CWX Alpha-1,2-mannosidase FDP11_RS05275 ENOG4105CWX Alpha-1,2-mannosidase FDP11_RS05285 ENOG4105CWX Alpha-1,2-mannosidase FDP11_RS05290 ENOG4105CWX Alpha-1,2-mannosidase FDP11_RS05295 ENOG4105EA8 2-Nitropropane dioxygenase FDP11_RS05300 ENOG4105CGH 5'-nucleotidase FDP11_RS05310 ENOG4107Z3H Transcriptional regulator, TetR family FDP11_RS05330 ENOG4105N14 lysine exporter protein LysE YggA FDP11_RS05345 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FDP11_RS05350 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FDP11_RS05355 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FDP11_RS05370 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FDP11_RS05395 ENOG4105E1Q flagellar hook-associated protein FDP11_RS05400 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FDP11_RS05405 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FDP11_RS05410 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FDP11_RS05415 ENOG4105CGA flagellar basal-body rod protein FlgG FDP11_RS05420 ENOG4108KPB Flagellar basal-body rod protein FlgF FDP11_RS05425 ENOG4105BZE flagellar hook protein, FlgE FDP11_RS05430 ENOG4105W00 Flagellar hook capping protein FDP11_RS05435 ENOG4108ZC9 flagellar basal-body rod protein flgc FDP11_RS05440 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FDP11_RS05460 ENOG4105E4C Lytic transglycosylase catalytic FDP11_RS05465 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FDP11_RS05485 ENOG4105EJQ L-serine dehydratase FDP11_RS05490 ENOG4105DUX Transporter FDP11_RS05510 ENOG4105ETT transcriptional Regulator, LysR family FDP11_RS05525 ENOG4105CJP fad dependent oxidoreductase FDP11_RS05550 ENOG4107RCV ABC transporter, permease FDP11_RS05565 ENOG4107STF Involved in phosphonate degradation (By similarity) FDP11_RS05570 ENOG4108JPW Aminotransferase FDP11_RS05575 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FDP11_RS05580 ENOG4105ETE Transcriptional regulator (LacI family FDP11_RS05610 ENOG4105KUU lipolytic protein G-D-S-L family FDP11_RS05620 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FDP11_RS05625 ENOG4105DJY efflux transporter, rnd family, mfp subunit FDP11_RS05630 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FDP11_RS05635 ENOG4108UHE carbonic anhydrase FDP11_RS05640 ENOG4108UUE Transcriptional regulator FDP11_RS05655 ENOG4105PAD Hydrolase FDP11_RS05660 ENOG4105JQN Transcriptional regulator FDP11_RS05695 ENOG4108UW5 maltose o-acetyltransferase FDP11_RS05700 ENOG4108UKZ OsmC family FDP11_RS05705 ENOG4105E0X reductase FDP11_RS05720 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein FDP11_RS05725 ENOG4105CVP deoxyribo-dipyrimidine photolyase FDP11_RS05730 ENOG4106TD9 Diguanylate cyclase FDP11_RS05745 ENOG4108N3W hemolysin secretion protein FDP11_RS05750 ENOG4105BZU Histidine kinase FDP11_RS05765 ENOG4105D9N nucleoside FDP11_RS05780 ENOG4105C0F tryptophanase EC 4.1.99.1 FDP11_RS05790 ENOG4105D5U fad dependent oxidoreductase FDP11_RS05805 ENOG4105CWM branched-chain amino acid transport system II carrier protein FDP11_RS05810 ENOG4105BZU Histidine kinase FDP11_RS05815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_RS05820 ENOG4105CQZ Histidine kinase FDP11_RS05850 ENOG4105DUM transcriptional regulator, lysR family FDP11_RS05855 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FDP11_RS05860 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FDP11_RS05870 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FDP11_RS05875 ENOG4105CYW agmatinase FDP11_RS05880 ENOG4105E5M Multidrug resistance protein D FDP11_RS05885 ENOG4105CUG Oligopeptidase b FDP11_RS05900 ENOG4105CC5 ABC transporter FDP11_RS05905 ENOG4105DIK (ABC) transporter FDP11_RS05910 ENOG4105DSE periplasmic solute binding protein FDP11_RS05950 ENOG4109015 Biopolymer transport protein exbD tolR FDP11_RS05975 ENOG410804D Sensor Signal Transduction Histidine Kinase FDP11_RS05980 ENOG4105E3W Two component transcriptional regulator (Winged helix family FDP11_RS05990 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FDP11_RS06000 ENOG4105C5I Dehydrogenase FDP11_RS06005 ENOG4108YYI Protein of unknown function (DUF2810) FDP11_RS06055 ENOG4108TEM pseudouridine methyltransferase FDP11_RS06070 ENOG4105DWF phosphomethylpyrimidine kinase FDP11_RS06075 ENOG4108YI8 ABC transporter FDP11_RS06080 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FDP11_RS06085 ENOG4107Z6I Thiamine biosynthesis protein FDP11_RS06090 ENOG4105ETU transcriptional activator (TenA FDP11_RS06095 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FDP11_RS06100 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FDP11_RS06110 ENOG4107QY8 reductase FDP11_RS06115 ENOG4105CUW cytochrome C-TYPE protein FDP11_RS06125 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FDP11_RS06160 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDP11_RS06165 ENOG4105BZW Glycerate kinase FDP11_RS06170 ENOG4105C6Z Gluconate FDP11_RS06175 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FDP11_RS06200 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FDP11_RS06225 ENOG4108WAV Transcriptional regulator FDP11_RS06230 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FDP11_RS06235 ENOG4108UVJ appr-1-p processing domain protein FDP11_RS06240 ENOG4107WCA isomerase FDP11_RS06260 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDP11_RS06270 ENOG4105EIF outer membrane protein W FDP11_RS06275 ENOG4107W31 Pentapeptide repeat protein FDP11_RS06295 ENOG4105EW9 transcriptional regulator AsnC family FDP11_RS06300 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_RS06305 ENOG4105Q26 Siderophore-interacting protein FDP11_RS06310 ENOG4105CAZ oligogalacturonide lyase FDP11_RS06335 ENOG4108UHU Aldolase FDP11_RS06340 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FDP11_RS06355 ENOG4105M5J Cupin 2, conserved barrel domain protein FDP11_RS06360 ENOG4105P66 Membrane FDP11_RS06365 ENOG4105CHR reductase FDP11_RS06370 ENOG4105J4Q Transcriptional regulator FDP11_RS06385 ENOG4105CC0 LysR family Transcriptional regulator FDP11_RS06390 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FDP11_RS06410 ENOG4108KHX Diguanylate cyclase FDP11_RS06420 ENOG4108HCJ Hydrolase FDP11_RS06425 ENOG4105EJC lysr family transcriptional regulator FDP11_RS06440 ENOG4105D3G Pseudouridine synthase FDP11_RS06445 ENOG4105UQX Mate efflux family protein FDP11_RS06450 ENOG4108K0B C-di-gmp phosphodiesterase FDP11_RS06460 ENOG4105NBK UPF0345 protein FDP11_RS06490 ENOG4105DN9 Na H antiporter FDP11_RS06510 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FDP11_RS06515 ENOG4105D03 DNA-3-methyladenine glycosylase II FDP11_RS06525 ENOG4108VGI doxx family FDP11_RS06530 ENOG4105C2I pirin domain protein FDP11_RS06550 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FDP11_RS06560 ENOG4105D6U Sodium Glutamate Symporter FDP11_RS06565 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDP11_RS06570 ENOG4105DVE abc transporter atp-binding protein FDP11_RS06580 ENOG4105D6U Sodium Glutamate Symporter FDP11_RS06600 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS06605 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FDP11_RS06615 ENOG4108VAC response regulator FDP11_RS06620 ENOG4108HRK Histidine kinase FDP11_RS06640 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FDP11_RS06650 ENOG4105CNI cell division protein FtsW FDP11_RS06655 ENOG4105CDY transcriptional regulatory protein FDP11_RS06665 ENOG4105BZU Histidine kinase FDP11_RS06690 ENOG4108JQ7 (ABC) transporter FDP11_RS06710 ENOG4106RMF ParB family FDP11_RS06715 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FDP11_RS06735 ENOG4105EC3 peptidase S51, dipeptidase E FDP11_RS06745 ENOG4105C5Y PTS System FDP11_RS06750 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FDP11_RS06755 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) FDP11_RS06765 ENOG4108J59 Extracellular solute-binding protein, family 5 FDP11_RS06780 ENOG4108JJA ABC, transporter FDP11_RS06795 ENOG4107QZV Type I secretion membrane fusion protein FDP11_RS06800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_RS06805 ENOG4105CQZ Histidine kinase FDP11_RS06810 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FDP11_RS06825 ENOG4105C26 Dehydrogenase FDP11_RS06835 ENOG4105CK7 Sodium proline symporter FDP11_RS06870 ENOG4105EW9 transcriptional regulator AsnC family FDP11_RS06880 ENOG4105BZ1 (ABC) transporter FDP11_RS06890 ENOG4105CF7 AraC family transcriptional regulator FDP11_RS06905 ENOG4105P66 Membrane FDP11_RS06910 ENOG4108UHU Aldolase FDP11_RS06915 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FDP11_RS06925 ENOG4105DEI Mannitol dehydrogenase FDP11_RS06930 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FDP11_RS06935 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FDP11_RS06940 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FDP11_RS06945 ENOG4105C6F GntR Family Transcriptional Regulator FDP11_RS06950 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FDP11_RS06955 ENOG4105C1J atp-dependent rna helicase FDP11_RS06960 ENOG4108RPX mosc domain containing protein FDP11_RS06975 ENOG4105F8D glycoside hydrolase family 4 FDP11_RS06980 ENOG4105W8I Transcriptional regulator FDP11_RS06985 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS06995 ENOG4105DU6 RNA polymerase FDP11_RS07000 ENOG4105ECQ AraC Family Transcriptional Regulator FDP11_RS07005 ENOG4105EXG Transcriptional regulator FDP11_RS07020 ENOG4108JU3 Alkyl hydroperoxide reductase FDP11_RS07025 ENOG4105D3R alkyl hydroperoxide reductase FDP11_RS07030 ENOG4105K56 Transcriptional regulator FDP11_RS07035 ENOG4108ZHJ Organic hydroperoxide resistance protein FDP11_RS07060 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FDP11_RS07070 ENOG4105EF1 ribulokinase FDP11_RS07075 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FDP11_RS07080 ENOG4105C2J ABC transporter FDP11_RS07085 ENOG4105CNN ABC, transporter FDP11_RS07100 ENOG4105CI1 PTS System FDP11_RS07110 ENOG4105DHQ Histidine kinase FDP11_RS07115 ENOG4108JP0 extracellular solute-binding protein family 1 FDP11_RS07120 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FDP11_RS07125 ENOG4105DBM Siderophore biosynthesis protein FDP11_RS07130 ENOG4105C6X Major Facilitator FDP11_RS07135 ENOG4105DUU IucA IucC family protein FDP11_RS07145 ENOG4105E0K tonB-dependent siderophore receptor FDP11_RS07150 ENOG4105GAV receptor FDP11_RS07155 ENOG4108HUF Transporter FDP11_RS07160 ENOG4105DQ5 transport system permease protein FDP11_RS07165 ENOG4108U1V ABC transporter, permease FDP11_RS07170 ENOG4105E0A ABC, transporter FDP11_RS07175 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS07180 ENOG4107RAN Peptidase, M16 FDP11_RS07190 ENOG4105DR5 peptidase FDP11_RS07215 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FDP11_RS07235 ENOG4108K8S endonuclease I FDP11_RS07255 ENOG4105CXN decarboxylase FDP11_RS07260 ENOG4105D5Q Arginine ornithine antiporter FDP11_RS07270 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FDP11_RS07280 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FDP11_RS07285 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FDP11_RS07315 ENOG41061ZR Transcriptional regulator FDP11_RS07320 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FDP11_RS07325 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FDP11_RS07330 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FDP11_RS07335 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FDP11_RS07340 ENOG4107T9C Alpha amylase catalytic region FDP11_RS07350 ENOG41074DU domain protein FDP11_RS07355 ENOG4108P2H Inner membrane protein YjiG FDP11_RS07360 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FDP11_RS07380 ENOG4105CK2 sodium dicarboxylate symporter FDP11_RS07390 ENOG4105F04 LysR family Transcriptional regulator FDP11_RS07395 ENOG4105N0V mono-oxygenase ydhR FDP11_RS07415 ENOG41081FY multiple antibiotic resistance (MarC)-related FDP11_RS07420 ENOG4108NRW Phospholipase, patatin family FDP11_RS07425 ENOG4108M1A Chitin-binding protein FDP11_RS07430 ENOG4105C72 UPF0176 protein FDP11_RS07445 ENOG4105DZ1 carboxypeptidase FDP11_RS07455 ENOG4108ZX5 transcriptional regulator FDP11_RS07460 ENOG4108RCM Nitroreductase FDP11_RS07470 ENOG4105ETT transcriptional Regulator, LysR family FDP11_RS07475 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FDP11_RS07485 ENOG4105DP0 ferredoxin-NADP reductase FDP11_RS07495 ENOG41068P6 UPF0319 protein FDP11_RS07500 ENOG4105IPI Membrane FDP11_RS07535 ENOG4105G2Y Transcriptional regulator FDP11_RS07540 ENOG4105CNH Multidrug resistance protein MdtL FDP11_RS07555 ENOG4105I4A GCN5-related N-acetyltransferase FDP11_RS07565 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FDP11_RS07570 ENOG4105F1A Pyruvate formate-lyase FDP11_RS07595 ENOG4105KWG Pfam:DUF1696 FDP11_RS07605 ENOG4105ER2 Ompa motb domain protein FDP11_RS07610 ENOG4107RD7 Flagellar Motor Protein, MotA FDP11_RS07635 ENOG4105MQ3 flagellar protein FliS FDP11_RS07640 ENOG410804A Flagellar hook-associated 2 domain-containing protein FDP11_RS07655 ENOG4105I03 Flagellin FDP11_RS07670 ENOG4105D00 flagellar biosynthetic protein flhB FDP11_RS07675 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FDP11_RS07680 ENOG4105VS8 Flagellar biosynthetic protein fliq FDP11_RS07685 ENOG4105CN7 Flagellar biosynthetic protein FliP FDP11_RS07690 ENOG4105DD5 Flagellar motor switch protein FDP11_RS07715 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FDP11_RS07720 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FDP11_RS07730 ENOG4108JIR Flagellum-specific ATP synthase FDP11_RS07760 ENOG4107SSZ Phosphatase FDP11_RS07780 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FDP11_RS07785 ENOG4105EXG Transcriptional regulator FDP11_RS07805 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FDP11_RS07815 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FDP11_RS07825 ENOG4107R0W ABC transporter FDP11_RS07830 ENOG4105BZU Histidine kinase FDP11_RS07835 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FDP11_RS07840 ENOG4105CPQ Dehydrogenase FDP11_RS07875 ENOG4105D64 Mechanosensitive ion channel FDP11_RS07885 ENOG4105DMF Dehydrogenase FDP11_RS07890 ENOG4105DAA L-lactate FDP11_RS07895 ENOG4105CC0 LysR family Transcriptional regulator FDP11_RS07905 ENOG4108JQ5 ABC transporter FDP11_RS07915 ENOG4105DAN ATP-dependent protease FDP11_RS07920 ENOG4108NVR Methyl-accepting chemotaxis FDP11_RS07925 ENOG4105YE1 PilZ domain FDP11_RS07940 ENOG4105WCN acetyltransferase FDP11_RS07945 ENOG4108BGM Quinol dehydrogenase periplasmic component FDP11_RS07950 ENOG4105GXZ Ferredoxin-type protein NapH FDP11_RS07965 ENOG4108JJB ABC transporter FDP11_RS07970 ENOG4108V7D UPF0397 protein FDP11_RS07975 ENOG4105EFX secretion protein, HlyD family FDP11_RS07980 ENOG4105KK7 inner membrane protein YiaW FDP11_RS07985 ENOG4106TD9 Diguanylate cyclase FDP11_RS08000 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FDP11_RS08005 ENOG4107SEY Conserved Protein FDP11_RS08010 ENOG4108XDN Transcriptional regulator FDP11_RS08015 ENOG4105CVP deoxyribo-dipyrimidine photolyase FDP11_RS08020 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FDP11_RS08030 ENOG4105C1J atp-dependent rna helicase FDP11_RS08035 ENOG4105CUG Oligopeptidase b FDP11_RS08040 ENOG4105D05 Receptor FDP11_RS08065 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FDP11_RS08070 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FDP11_RS08075 ENOG4105BZU Histidine kinase FDP11_RS08080 ENOG4106IUH DTW domain containing protein FDP11_RS08095 ENOG4105DQF Hydrolase FDP11_RS08100 ENOG4108EUD Lysophospholipase FDP11_RS08105 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_RS08110 ENOG4105D58 Diguanylate phosphodiesterase FDP11_RS08115 ENOG41082YX Transcriptional regulator, arsr family FDP11_RS08120 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FDP11_RS08170 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FDP11_RS08180 ENOG4106H78 methyltransferase FDP11_RS08185 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FDP11_RS08190 ENOG4105CAK Cell division ATP-binding protein ftsE FDP11_RS08195 ENOG4105CRP Part of the ABC transporter FtsEX involved in FDP11_RS08200 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDP11_RS08205 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FDP11_RS08210 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) FDP11_RS08215 ENOG4105X6C Flagellar basal body-associated protein FliL FDP11_RS08220 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FDP11_RS08225 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FDP11_RS08230 ENOG4105E55 glycerol-3-phosphate acyltransferase FDP11_RS08235 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FDP11_RS08245 ENOG4107R73 Mate efflux family protein FDP11_RS08250 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FDP11_RS08265 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) FDP11_RS08270 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FDP11_RS08280 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FDP11_RS08310 ENOG4105JIM Phosphatidylserine synthase FDP11_RS08320 ENOG4105D4A Cell wall formation (By similarity) FDP11_RS08325 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FDP11_RS08330 ENOG4105CS9 pantothenic acid kinase FDP11_RS08355 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FDP11_RS08360 ENOG4105PM1 preprotein translocase subunit SecE FDP11_RS08365 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FDP11_RS08370 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FDP11_RS08375 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FDP11_RS08380 ENOG4108VZM 50s ribosomal protein L10 FDP11_RS08385 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FDP11_RS08390 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDP11_RS08395 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDP11_RS08400 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor FDP11_RS08405 ENOG4105E09 nadh pyrophosphatase FDP11_RS08420 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FDP11_RS08425 ENOG4108RG0 uracil-dna glycosylase FDP11_RS08430 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FDP11_RS08435 ENOG4105R2J Conserved Protein FDP11_RS08455 ENOG4105C12 Phosphoribosylglycinamide synthetase FDP11_RS08460 ENOG4105DC1 bifunctional purine biosynthesis protein purh FDP11_RS08465 ENOG4105W1Y Transcriptional regulator FDP11_RS08470 ENOG4108M3R transcriptional activator CadC FDP11_RS08475 ENOG4105D5Q Arginine ornithine antiporter FDP11_RS08480 ENOG4105CXN decarboxylase FDP11_RS08575 ENOG4105BZU Histidine kinase FDP11_RS08580 ENOG4105C5H ABC transporter FDP11_RS08585 ENOG4107XZQ multidrug resistance protein FDP11_RS08590 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FDP11_RS08595 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FDP11_RS08600 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FDP11_RS08605 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FDP11_RS08610 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FDP11_RS08615 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FDP11_RS08620 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FDP11_RS08635 ENOG4105D8G Major Facilitator superfamily FDP11_RS08640 ENOG4105BZU Histidine kinase FDP11_RS08645 ENOG4105C9Q fumarate hydratase class II FDP11_RS08660 ENOG4107QN1 sodium solute FDP11_RS08670 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FDP11_RS08680 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FDP11_RS08685 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FDP11_RS08690 ENOG4108IJ0 Aspartate ammonia-lyase FDP11_RS08695 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FDP11_RS08700 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FDP11_RS08710 ENOG4105E0F Histidine kinase FDP11_RS08715 ENOG4105E3W Two component transcriptional regulator (Winged helix family FDP11_RS08720 ENOG4108SPG Periplasmic Protein FDP11_RS08725 ENOG41076HS cation diffusion facilitator family transporter FDP11_RS08730 ENOG4105CTQ phosphohexokinase FDP11_RS08740 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FDP11_RS08745 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FDP11_RS08760 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FDP11_RS08765 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FDP11_RS08770 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FDP11_RS08780 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FDP11_RS08785 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FDP11_RS08790 ENOG4105E33 succinate dehydrogenase FDP11_RS08800 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FDP11_RS08810 ENOG41062JF Transcriptional regulator FDP11_RS08820 ENOG41063SB peptidase FDP11_RS08825 ENOG4105D7W serine acetyltransferase FDP11_RS08830 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FDP11_RS08835 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FDP11_RS08840 ENOG4107YZP Rhodanese domain protein FDP11_RS08845 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FDP11_RS08855 ENOG4108NVR Methyl-accepting chemotaxis FDP11_RS08860 ENOG4105C8P )-transporter FDP11_RS08865 ENOG4105DJ4 phosphatidylserine decarboxylase FDP11_RS08870 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FDP11_RS08875 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FDP11_RS08945 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FDP11_RS08950 ENOG4105K8N protein family UPF0079, ATPase FDP11_RS08955 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FDP11_RS08960 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FDP11_RS08965 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FDP11_RS08970 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FDP11_RS08975 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FDP11_RS08980 ENOG4107QJR hflk protein FDP11_RS08985 ENOG4105EPW hflc protein FDP11_RS08995 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FDP11_RS09000 ENOG4108UV7 flagellar protein motX FDP11_RS09005 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FDP11_RS09010 ENOG4105KPV Transcriptional regulator FDP11_RS09015 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FDP11_RS09020 ENOG4105C2N RNA methyltransferase TrmH family group 3 FDP11_RS09025 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FDP11_RS09030 ENOG4105C31 Tryptophanyl-tRNA synthetase FDP11_RS09045 ENOG4105DDQ anthranilate synthase FDP11_RS09050 ENOG4105C8Y Acetylornithine aminotransferase FDP11_RS09060 ENOG4105C26 Dehydrogenase FDP11_RS09075 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FDP11_RS09080 ENOG4105YP7 UPF0270 protein FDP11_RS09085 ENOG4105DNZ Alpha Beta Hydrolase FDP11_RS09095 ENOG4105C5H ABC transporter FDP11_RS09100 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FDP11_RS09115 ENOG4108YZY peptidylprolyl cis-trans isomerase FDP11_RS09120 ENOG4105D44 asparaginase FDP11_RS09125 ENOG41069P5 Protein slyX homolog FDP11_RS09135 ENOG4108V1T peptidylprolyl cis-trans isomerase FDP11_RS09140 ENOG4105WWK YheO domain protein FDP11_RS09145 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FDP11_RS09150 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FDP11_RS09155 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FDP11_RS09160 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FDP11_RS09165 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FDP11_RS09170 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FDP11_RS09175 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FDP11_RS09180 ENOG4105W53 bacterioferritin-associated ferredoxin FDP11_RS09185 ENOG4108UQY Iron-storage protein FDP11_RS09190 ENOG4105C6K Malic enzyme FDP11_RS09195 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) FDP11_RS09200 ENOG4105C28 cystathionine FDP11_RS09205 ENOG4105CFH Aspartokinase FDP11_RS09210 ENOG4105SYT Methylenetetrahydrofolate reductase FDP11_RS09220 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FDP11_RS09225 ENOG4105CWC Acetylornithine deacetylase FDP11_RS09230 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FDP11_RS09235 ENOG4105CAS nag kinase FDP11_RS09240 ENOG4105CDH Citrulline--aspartate ligase FDP11_RS09245 ENOG4105CH7 arginosuccinase FDP11_RS09255 ENOG4105EHV domain protein FDP11_RS09265 ENOG4108JQC penicillin-binding protein 1A FDP11_RS09290 ENOG4105E4G Type IV pilus FDP11_RS09295 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FDP11_RS09300 ENOG4105D49 3-dehydroquinate synthase FDP11_RS09310 ENOG4105DFE Dna adenine methylase FDP11_RS09315 ENOG4105DJV ribulose-phosphate 3-epimerase FDP11_RS09320 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FDP11_RS09325 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) FDP11_RS09330 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FDP11_RS09335 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FDP11_RS09345 ENOG4105CDU Replicative dna helicase FDP11_RS09350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FDP11_RS09395 ENOG4105CAF HipA N-terminal domain protein FDP11_RS09455 ENOG4107QP8 phosphohexose isomerase FDP11_RS09465 ENOG4105MYN Zinc uptake regulation protein FDP11_RS09470 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FDP11_RS09490 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FDP11_RS09495 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FDP11_RS09500 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FDP11_RS09560 ENOG4105EEQ Na H antiporter FDP11_RS09565 ENOG4105C3R Methionine synthase FDP11_RS09570 ENOG4105CFH Aspartokinase FDP11_RS09575 ENOG4105C5R Aminotransferase FDP11_RS09585 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FDP11_RS09590 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FDP11_RS09595 ENOG41086KC Transcriptional regulator FDP11_RS09600 ENOG4108UUM single-stranded DNA-binding protein FDP11_RS09605 ENOG41062P1 Diguanylate cyclase phosphodiesterase FDP11_RS09625 ENOG4105E4G Type IV pilus FDP11_RS09640 ENOG4107QHF type ii secretion system protein e FDP11_RS09645 ENOG4105D7Q type ii secretion system FDP11_RS09695 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FDP11_RS09700 ENOG4105VQ7 Rod shape-determining protein MreD FDP11_RS09705 ENOG4108Z03 MAF-like protein FDP11_RS09710 ENOG4105C03 ribonuclease FDP11_RS09715 ENOG4105QD6 exported protein FDP11_RS09725 ENOG4105D1U peptidase U62 modulator of DNA gyrase FDP11_RS09730 ENOG4108IAB Phoh family FDP11_RS09735 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FDP11_RS09740 ENOG4105K3M )-transporter FDP11_RS09745 ENOG4105D3G Pseudouridine synthase FDP11_RS09750 ENOG4105C5I Dehydrogenase FDP11_RS09755 ENOG4105N42 UPF0307 protein FDP11_RS09760 ENOG4105CMS peptidase U62, modulator of DNA gyrase FDP11_RS09765 ENOG4105CJW magnesium transporter FDP11_RS09770 ENOG41080Z8 PHOSPHOCARRIER protein FDP11_RS09775 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FDP11_RS09780 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FDP11_RS09785 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FDP11_RS09790 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDP11_RS09795 ENOG4108IUZ ABC transporter FDP11_RS09800 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FDP11_RS09810 ENOG4105C2X Arabinose 5-phosphate isomerase FDP11_RS09820 ENOG4105DHJ ABC, transporter FDP11_RS09825 ENOG4105CY3 ABC transporter, permease FDP11_RS09830 ENOG4107PE3 Mammalian cell entry related domain protein FDP11_RS09835 ENOG4105E3I toluene tolerance FDP11_RS09845 ENOG4105VFK BolA family FDP11_RS09850 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FDP11_RS09855 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FDP11_RS09860 ENOG4105KME endoribonuclease L-psp FDP11_RS09865 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) FDP11_RS09870 ENOG4105CXT aspartate transcarbamylase FDP11_RS09880 ENOG4105DBV ornithine carbamoyltransferase FDP11_RS09885 ENOG4105CEU Arginine dihydrolase FDP11_RS09900 ENOG4108MJ3 acetyltransferase FDP11_RS09910 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FDP11_RS09915 ENOG4105MYG DNA polymerase iii, chi subunit FDP11_RS09920 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FDP11_RS09925 ENOG4108M8S permease YjgP YjgQ family protein FDP11_RS09930 ENOG4108K5H permease YjgP YjgQ family protein FDP11_RS09945 ENOG4107JEE Short-chain dehydrogenase reductase Sdr FDP11_RS09955 ENOG41062JF Transcriptional regulator FDP11_RS09980 ENOG4105VZJ PTS System FDP11_RS09985 ENOG4105CK1 PTS System FDP11_RS09990 ENOG4105VCP PTS System FDP11_RS09995 ENOG4105F8D glycoside hydrolase family 4 FDP11_RS10000 ENOG410901P UPF0249 protein FDP11_RS10010 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FDP11_RS10055 ENOG4105C26 Dehydrogenase FDP11_RS10085 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS10125 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FDP11_RS10130 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FDP11_RS10135 ENOG4105CEN a g-specific adenine glycosylase FDP11_RS10140 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FDP11_RS10150 ENOG4105CSV Glutaminase FDP11_RS10155 ENOG4105CSA Coproporphyrinogen iii oxidase FDP11_RS10160 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FDP11_RS10170 ENOG4105VZ9 UPF0235 protein FDP11_RS10175 ENOG4108VIA integral membrane protein FDP11_RS10180 ENOG4105II7 pyrroline-5-carboxylate reductase FDP11_RS10185 ENOG4105DFA alanine racemase domain protein FDP11_RS10190 ENOG4105CZX twitching motility protein FDP11_RS10195 ENOG4105CZX twitching motility protein FDP11_RS10200 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FDP11_RS10205 ENOG4108UJU UPF0301 protein FDP11_RS10210 ENOG4105D7Z glutathione synthase FDP11_RS10215 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FDP11_RS10220 ENOG4105RWS endonuclease I FDP11_RS10225 ENOG4105GPY SprT protein FDP11_RS10235 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FDP11_RS10240 ENOG4105CV1 Transketolase (EC 2.2.1.1) FDP11_RS10245 ENOG4108R4R Iron-regulated virulence regulatory protein FDP11_RS10250 ENOG4105D05 Receptor FDP11_RS10255 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FDP11_RS10260 ENOG4105BZA Phosphoglycerate kinase FDP11_RS10265 ENOG4105D2N Aldolase FDP11_RS10270 ENOG4105D64 Mechanosensitive ion channel FDP11_RS10275 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FDP11_RS10285 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FDP11_RS10290 ENOG4105MPN Membrane FDP11_RS10295 ENOG4108JQ1 Dehydrogenase FDP11_RS10300 ENOG4105E66 phosphoriboisomerase A FDP11_RS10305 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FDP11_RS10315 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FDP11_RS10325 ENOG4105D0A hydroxylase FDP11_RS10330 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FDP11_RS10345 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FDP11_RS10350 ENOG4105Y75 tpr repeat protein FDP11_RS10355 ENOG4108IYU L-aspartate oxidase FDP11_RS10360 ENOG4105EMN RNA polymerase sigma factor FDP11_RS10365 ENOG41069PW sigma-e factor negative regulatory protein FDP11_RS10380 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FDP11_RS10385 ENOG4105C3F Signal peptidase i FDP11_RS10390 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FDP11_RS10395 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FDP11_RS10400 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FDP11_RS10405 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FDP11_RS10410 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FDP11_RS10415 ENOG4105BZU Histidine kinase FDP11_RS10420 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FDP11_RS10425 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FDP11_RS10430 ENOG4105DXN mazG family FDP11_RS10435 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FDP11_RS10440 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FDP11_RS10445 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FDP11_RS10450 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FDP11_RS10455 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FDP11_RS10460 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) FDP11_RS10465 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FDP11_RS10470 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FDP11_RS10480 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDP11_RS10485 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FDP11_RS10490 ENOG4107TH8 cina domain protein FDP11_RS10495 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FDP11_RS10500 ENOG4105Y3E Modulates RecA activity (By similarity) FDP11_RS10505 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FDP11_RS10510 ENOG4105CFH Aspartokinase FDP11_RS10515 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FDP11_RS10570 ENOG4106AFN Lyase and sodium transporter (By similarity) FDP11_RS10575 ENOG4107QSA Oxaloacetate decarboxylase FDP11_RS10580 ENOG4105D9Q decarboxylase (Beta subunit) FDP11_RS10585 ENOG4105CPQ Dehydrogenase FDP11_RS10590 ENOG4105W39 Membrane FDP11_RS10600 ENOG4105D9M gamma-glutamylcysteine synthetase FDP11_RS10610 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FDP11_RS10615 ENOG4108JU6 CBS domain protein FDP11_RS10620 ENOG4106KVJ cytochrome C assembly protein FDP11_RS10625 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FDP11_RS10630 ENOG4105K5M 30s ribosomal protein S16 FDP11_RS10635 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FDP11_RS10640 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FDP11_RS10645 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FDP11_RS10650 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FDP11_RS10655 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) FDP11_RS10660 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FDP11_RS10665 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FDP11_RS10670 ENOG4105D7Q type ii secretion system FDP11_RS10675 ENOG4107QHF type ii secretion system protein e FDP11_RS10685 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FDP11_RS10695 ENOG41073TP transcriptional regulator FDP11_RS10700 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FDP11_RS10705 ENOG4107QSN dihydrolipoamide acetyltransferase FDP11_RS10710 ENOG4107QN2 dihydrolipoyl dehydrogenase FDP11_RS10715 ENOG410630P Transcriptional regulator FDP11_RS10720 ENOG4108UGV hypoxanthine phosphoribosyltransferase FDP11_RS10725 ENOG41077A9 carbonic anhydrase FDP11_RS10730 ENOG4105CHH sulfate transporter FDP11_RS10735 ENOG4105DA5 (ABC) transporter FDP11_RS10740 ENOG4105E3A (ABC) transporter FDP11_RS10745 ENOG4105D1S lipid A biosynthesis FDP11_RS10750 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FDP11_RS10755 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FDP11_RS10760 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FDP11_RS10765 ENOG4105DJ0 Poly(A) Polymerase FDP11_RS10770 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FDP11_RS10775 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FDP11_RS10780 ENOG4105PW4 Sugar fermentation stimulation protein homolog FDP11_RS10785 ENOG4105CQ7 ATP-dependent helicase FDP11_RS10790 ENOG4105BZ4 penicillin-binding protein FDP11_RS10795 ENOG4105D78 K07001 NTE family protein FDP11_RS10800 ENOG4107QIJ Aconitate hydratase 2 FDP11_RS10805 ENOG4105XTV UPF0231 protein FDP11_RS10810 ENOG4108YZA Nitrogen regulatory protein pii FDP11_RS10830 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS10835 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FDP11_RS10845 ENOG4105E2D ec 3.2.1.52 FDP11_RS10850 ENOG4105RD7 BadF BadG BcrA BcrD FDP11_RS10860 ENOG4108JQ7 (ABC) transporter FDP11_RS10865 ENOG4105C3U ABC transporter FDP11_RS10870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDP11_RS10880 ENOG4107QRA Extracellular solute-binding protein, family 5 FDP11_RS10885 ENOG4105BZU Histidine kinase FDP11_RS10890 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FDP11_RS10895 ENOG4105IPI Membrane FDP11_RS10900 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FDP11_RS10905 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FDP11_RS10915 ENOG4105BZS acriflavin resistance protein FDP11_RS10920 ENOG4105DR5 peptidase FDP11_RS10925 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FDP11_RS10930 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FDP11_RS10935 ENOG4108ETH Formylglycinamide ribotide synthetase FDP11_RS10960 ENOG4105CIN aminoacyl-histidine dipeptidase FDP11_RS10965 ENOG4105C7N Xanthine uracil vitamin C permease FDP11_RS10970 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FDP11_RS10975 ENOG4108DJV Fermentation respiration switch protein FDP11_RS10980 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) FDP11_RS10985 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FDP11_RS10990 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FDP11_RS10995 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FDP11_RS11000 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FDP11_RS11015 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FDP11_RS11020 ENOG4107YIM Involved in the transcription termination process (By similarity) FDP11_RS11025 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FDP11_RS11030 ENOG4108ZAI phosphatidylglycerophosphatase a FDP11_RS11035 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FDP11_RS11040 ENOG4105CTB Polyprenyl synthetase FDP11_RS11045 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FDP11_RS11050 ENOG4105E14 MotA TolQ exbB proton channel FDP11_RS11055 ENOG4107QKZ Ompa motb domain protein FDP11_RS11060 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FDP11_RS11065 ENOG4105ETT transcriptional Regulator, LysR family FDP11_RS11075 ENOG4105M08 Membrane FDP11_RS11080 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) FDP11_RS11090 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease FDP11_RS11095 ENOG4105EWT decarboxylase family FDP11_RS11110 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FDP11_RS11115 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FDP11_RS11120 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein FDP11_RS11125 ENOG4105D01 (LipO)protein FDP11_RS11130 ENOG4108UMI ABC transporter, permease FDP11_RS11135 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS11140 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FDP11_RS11145 ENOG4105D4X repressor FDP11_RS11150 ENOG4105C5Y PTS System FDP11_RS11155 ENOG4105CG3 alpha amylase, catalytic region FDP11_RS11170 ENOG4108JYZ YitT family FDP11_RS11175 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FDP11_RS11180 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FDP11_RS11185 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FDP11_RS11190 ENOG4108Z43 UPF0250 protein FDP11_RS11195 ENOG4105DZ1 carboxypeptidase FDP11_RS11200 ENOG4105K6T rare lipoprotein A FDP11_RS11205 ENOG4105CNI cell division protein FtsW FDP11_RS11210 ENOG4105CJN penicillin-binding protein FDP11_RS11215 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FDP11_RS11220 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FDP11_RS11225 ENOG4105DJF DNA polymerase III, delta' subunit FDP11_RS11230 ENOG4108U2H Rare lipoprotein B FDP11_RS11235 ENOG4105C8T Leucyl-tRNA synthetase FDP11_RS11240 ENOG4107PAI alpha helical protein FDP11_RS11245 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FDP11_RS11250 ENOG4108JU5 Magnesium and cobalt efflux protein FDP11_RS11255 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FDP11_RS11260 ENOG4105C9A Phoh family FDP11_RS11265 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FDP11_RS11270 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FDP11_RS11385 ENOG4105C3G gtp-binding protein FDP11_RS11390 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FDP11_RS11395 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FDP11_RS11400 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FDP11_RS11405 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FDP11_RS11410 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FDP11_RS11415 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FDP11_RS11420 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FDP11_RS11425 ENOG4108YY7 Invasion gene expression up-regulator SirB FDP11_RS11430 ENOG41063JG Transcriptional regulator FDP11_RS11435 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FDP11_RS11440 ENOG4105CGH 5'-nucleotidase FDP11_RS11445 ENOG4108Z66 YbaK ebsC protein FDP11_RS11450 ENOG4105FE9 pseudouridine synthase FDP11_RS11455 ENOG4108DG9 Smr protein MutS2 FDP11_RS11475 ENOG4105E2D ec 3.2.1.52 FDP11_RS11490 ENOG4105C59 p-type ATPase FDP11_RS11495 ENOG41081QG Porin Gram-negative type FDP11_RS11505 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FDP11_RS11510 ENOG4105UYK outer membrane protein a FDP11_RS11555 ENOG4107R88 Chemotaxis protein (CheV) FDP11_RS11560 ENOG4105BZU Histidine kinase FDP11_RS11565 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FDP11_RS11570 ENOG4108ZC9 flagellar basal-body rod protein flgc FDP11_RS11575 ENOG4105W00 Flagellar hook capping protein FDP11_RS11580 ENOG4105BZE flagellar hook protein, FlgE FDP11_RS11585 ENOG4108KPB Flagellar basal-body rod protein FlgF FDP11_RS11590 ENOG4105CGA flagellar basal-body rod protein FlgG FDP11_RS11595 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FDP11_RS11600 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FDP11_RS11605 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FDP11_RS11615 ENOG4105DTJ flagellar hook-associated protein FDP11_RS11620 ENOG4105I03 Flagellin FDP11_RS11625 ENOG4105I03 Flagellin FDP11_RS11635 ENOG4105C5Y PTS System FDP11_RS11640 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FDP11_RS11645 ENOG4105KZ7 phosphocarrier protein hpr FDP11_RS11650 ENOG4105C6T cysteine synthase FDP11_RS11655 ENOG4105EXN Sulfate transport protein CysZ FDP11_RS11660 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) FDP11_RS11665 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FDP11_RS11690 ENOG4107QX8 SPFH domain, Band 7 family protein FDP11_RS11695 ENOG4105D1V cellulose synthase operon protein YhjU FDP11_RS11705 ENOG4105U74 cellulose biosynthesis protein BcsE FDP11_RS11720 ENOG4107QZ7 Cellulose synthase catalytic subunit FDP11_RS11725 ENOG4107EEX Cellulose synthase regulator protein FDP11_RS11730 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FDP11_RS11735 ENOG4105EJG cellulose synthase FDP11_RS11740 ENOG4107QR8 Thioredoxin FDP11_RS11745 ENOG4105E1F short-chain dehydrogenase reductase FDP11_RS11750 ENOG4105ECP epimerase FDP11_RS11775 ENOG4108RE9 Phosphodiesterase FDP11_RS11795 ENOG4108DQ1 activator toxR FDP11_RS11800 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FDP11_RS11805 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FDP11_RS11810 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FDP11_RS11815 ENOG4105DUX Transporter FDP11_RS11820 ENOG4105MDZ Transcriptional activator rfaH FDP11_RS11825 ENOG4105CAQ asparagine synthetase FDP11_RS11830 ENOG4105CKD glutathione-regulated potassium-efflux system protein FDP11_RS11835 ENOG4105E2R ROK family FDP11_RS11840 ENOG4105CE4 GlcNAc 6-P deacetylase FDP11_RS11850 ENOG4105CX6 glutaminyL-tRNA synthetase FDP11_RS11855 ENOG41090R7 Ferric uptake FDP11_RS11865 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FDP11_RS11875 ENOG4105EV9 Alpha Beta Hydrolase FDP11_RS11880 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) FDP11_RS11885 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FDP11_RS11895 ENOG4107QNR UPF0135 protein FDP11_RS11900 ENOG4105BZN citrate synthase FDP11_RS11905 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FDP11_RS11910 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FDP11_RS11915 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FDP11_RS11920 ENOG4105E33 succinate dehydrogenase FDP11_RS11925 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FDP11_RS11930 ENOG4105C7S Dehydrogenase FDP11_RS11935 ENOG4105CMV Succinyl-CoA synthetase subunit beta FDP11_RS11940 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FDP11_RS11945 ENOG4108V3E phosphoribosylglycinamide formyltransferase FDP11_RS11950 ENOG4105CXB phosphoribosylaminoimidazole synthetase FDP11_RS11955 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FDP11_RS11960 ENOG4105C2W permease FDP11_RS11975 ENOG4105CS1 NAD(P)H quinone oxidoreductase FDP11_RS11980 ENOG4105K89 arsenate reductase FDP11_RS11985 ENOG4105ERG peptidase m48, ste24p FDP11_RS12000 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FDP11_RS12005 ENOG4105RH4 Glycine cleavage system transcriptional repressor FDP11_RS12015 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FDP11_RS12030 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FDP11_RS12035 ENOG4105KUZ arsenate reductase FDP11_RS12055 ENOG4105QZU Inner membrane protein YfeZ FDP11_RS12060 ENOG4105EZR dyp-type peroxidase family protein FDP11_RS12065 ENOG4105I03 Flagellin FDP11_RS12070 ENOG4105I03 Flagellin FDP11_RS12075 ENOG4105I03 Flagellin FDP11_RS12080 ENOG41063QE flagellar protein FlaG FDP11_RS12085 ENOG4107BRV flagellar capping protein FDP11_RS12095 ENOG4105MQ3 flagellar protein FliS FDP11_RS12105 ENOG4105BZU Histidine kinase FDP11_RS12115 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FDP11_RS12120 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FDP11_RS12125 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FDP11_RS12135 ENOG4108JIR Flagellum-specific ATP synthase FDP11_RS12155 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FDP11_RS12160 ENOG4105DD5 Flagellar motor switch protein FDP11_RS12165 ENOG4105VTB flagellar biosynthesis protein fliO FDP11_RS12170 ENOG4105CN7 Flagellar biosynthetic protein FliP FDP11_RS12175 ENOG4105VS8 Flagellar biosynthetic protein fliq FDP11_RS12180 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FDP11_RS12185 ENOG4105D00 flagellar biosynthetic protein flhB FDP11_RS12190 ENOG4105D7B Flagellar biosynthesis protein flha FDP11_RS12195 ENOG4105FZW flagellar biosynthesis regulator FlhF FDP11_RS12205 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDP11_RS12210 ENOG4108VYJ response regulator receiver protein FDP11_RS12215 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FDP11_RS12225 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FDP11_RS12230 ENOG4107QJE Chromosome Partitioning Protein FDP11_RS12240 ENOG4108V3W Chemotaxis protein, CheW FDP11_RS12250 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FDP11_RS12255 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FDP11_RS12260 ENOG41060IM Heme exporter protein FDP11_RS12265 ENOG4105X3C heme exporter protein FDP11_RS12270 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FDP11_RS12275 ENOG4105DA4 cytochrome c-type biogenesis protein FDP11_RS12280 ENOG4107QX9 Thiol disulfide interChange protein FDP11_RS12285 ENOG4108M1T Cytochrome c-type biogenesis protein FDP11_RS12295 ENOG410903C (LipO)protein FDP11_RS12300 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FDP11_RS12305 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FDP11_RS12320 ENOG4105CHU acetyl-coa acetyltransferase FDP11_RS12325 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FDP11_RS12335 ENOG4107QXK peptidase FDP11_RS12340 ENOG4108BY2 phosphohistidine phosphatase FDP11_RS12345 ENOG4108DG9 Smr protein MutS2 FDP11_RS12350 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FDP11_RS12355 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FDP11_RS12360 ENOG4105EN6 Membrane FDP11_RS12365 ENOG4108BPE -transporting atpase FDP11_RS12370 ENOG4105MH2 YfcL protein FDP11_RS12375 ENOG4105Q8W reductase FDP11_RS12380 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FDP11_RS12385 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FDP11_RS12390 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) FDP11_RS12395 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FDP11_RS12405 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FDP11_RS12410 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FDP11_RS12415 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FDP11_RS12420 ENOG4108S3P Sporulation domain protein FDP11_RS12425 ENOG4105E96 Colicin v production protein FDP11_RS12430 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FDP11_RS12435 ENOG4105EJC lysr family transcriptional regulator FDP11_RS12440 ENOG4105I93 response regulator FDP11_RS12445 ENOG4105WD1 Membrane FDP11_RS12450 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FDP11_RS12455 ENOG4107QMP dna polymerase iii subunits gamma and tau FDP11_RS12460 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FDP11_RS12465 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FDP11_RS12470 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FDP11_RS12475 ENOG4105C44 Serine transporter FDP11_RS12480 ENOG4105KME endoribonuclease L-psp FDP11_RS12485 ENOG4105CEM UPF0597 protein FDP11_RS12495 ENOG4105KRS Proteinase inhibitor FDP11_RS12500 ENOG4105Y3U Transglycosylase-associated protein FDP11_RS12505 ENOG4108ZZ3 UPF0260 protein FDP11_RS12515 ENOG41067V3 Antibiotic biosynthesis monooxygenase FDP11_RS12520 ENOG4108UYE Lactoylglutathione lyase FDP11_RS12530 ENOG4105G6Z alkaline phosphatase FDP11_RS12545 ENOG4105DHI Methyltransferase FDP11_RS12550 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS12555 ENOG4105DSB aldose 1-epimerase FDP11_RS12560 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FDP11_RS12565 ENOG4105E0X reductase FDP11_RS12575 ENOG4105VUT cytoplasmic protein FDP11_RS12580 ENOG4105HDK L-asparaginase FDP11_RS12585 ENOG4105D07 Signal peptide peptidase, SppA FDP11_RS12590 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDP11_RS12595 ENOG41069NU Nitroreductase FDP11_RS12600 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FDP11_RS12610 ENOG4108RU0 short-chain dehydrogenase reductase FDP11_RS12615 ENOG4105DGU Histone deacetylase FDP11_RS12625 ENOG4105E68 Sulfatase FDP11_RS12630 ENOG4105YDX UPF0352 protein FDP11_RS12635 ENOG4106V8H Nucleoid-associated protein FDP11_RS12650 ENOG4105DFD Na H antiporter FDP11_RS12655 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FDP11_RS12660 ENOG4105EYW Ion transport protein FDP11_RS12665 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FDP11_RS12670 ENOG4105C0A alcohol dehydrogenase FDP11_RS12685 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FDP11_RS12690 ENOG4105M2J Glutaredoxin FDP11_RS12700 ENOG4105D3Y Na H antiporter FDP11_RS12705 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FDP11_RS12710 ENOG4105EIY sodium-type flagellar protein motY FDP11_RS12715 ENOG4106WH9 Protein of unknown function (DUF2753) FDP11_RS12720 ENOG4108UYE Lactoylglutathione lyase FDP11_RS12725 ENOG4105CSM endonuclease III FDP11_RS12730 ENOG4105DZB Electron transport complex FDP11_RS12735 ENOG4108UQQ Electron transport complex FDP11_RS12740 ENOG4105D6A Electron transport complex FDP11_RS12750 ENOG4108R3D Electron transport complex FDP11_RS12755 ENOG4105DGN Electron transport complex FDP11_RS12770 ENOG4105CGK Exodeoxyribonuclease III FDP11_RS12775 ENOG4106428 Protein of unknown function (DUF2496) FDP11_RS12780 ENOG4108URS primosomal replication protein n'' FDP11_RS12785 ENOG4105EJ9 Membrane FDP11_RS12790 ENOG4105DVT helicase FDP11_RS12805 ENOG4108R99 pseudouridine synthase FDP11_RS12815 ENOG4105VEQ Cold shock protein FDP11_RS12820 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FDP11_RS12825 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FDP11_RS12835 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FDP11_RS12840 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate FDP11_RS12845 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FDP11_RS12855 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FDP11_RS12860 ENOG4105RKX Protein of unknown function (DUF2498) FDP11_RS12865 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FDP11_RS12870 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FDP11_RS12875 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FDP11_RS12895 ENOG4105HP8 regulator of competence-specific genes FDP11_RS12900 ENOG4105ETE Transcriptional regulator (LacI family FDP11_RS12905 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) FDP11_RS12910 ENOG4106WF9 DNA-binding transcriptional regulator TorR FDP11_RS12915 ENOG4107S90 membrAne FDP11_RS12920 ENOG4106371 Methyltransferase FDP11_RS12925 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) FDP11_RS12930 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FDP11_RS12935 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) FDP11_RS12945 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FDP11_RS12955 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FDP11_RS12960 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FDP11_RS12965 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FDP11_RS12970 ENOG41081XQ Conserved Protein FDP11_RS12975 ENOG4105C9M aspartyl-trna synthetase FDP11_RS12980 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FDP11_RS12985 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS12990 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FDP11_RS12995 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FDP11_RS13000 ENOG4105C4M (Ubiquinol oxidase) subunit I FDP11_RS13005 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FDP11_RS13020 ENOG4107YD3 Thioesterase FDP11_RS13025 ENOG4105E02 MotA TolQ exbB proton channel FDP11_RS13030 ENOG4105M8F Biopolymer transport protein exbD tolR FDP11_RS13040 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FDP11_RS13045 ENOG4105KCK Peptidoglycan-associated lipoprotein FDP11_RS13050 ENOG4105UFD tol-pal system protein YbgF FDP11_RS13055 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FDP11_RS13060 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FDP11_RS13065 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FDP11_RS13070 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FDP11_RS13075 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FDP11_RS13085 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FDP11_RS13090 ENOG4105D1F ATP-binding protein FDP11_RS13095 ENOG4105DBI uridine monophosphokinase FDP11_RS13105 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FDP11_RS13115 ENOG4105CHH sulfate transporter FDP11_RS13120 ENOG4105C03 ribonuclease FDP11_RS13125 ENOG4105EI2 Pseudouridine synthase FDP11_RS13130 ENOG4108UHJ MAF-like protein FDP11_RS13135 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FDP11_RS13140 ENOG4105VGS 50s ribosomal protein l32 FDP11_RS13145 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FDP11_RS13150 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FDP11_RS13155 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FDP11_RS13160 ENOG4105CHR reductase FDP11_RS13165 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FDP11_RS13170 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FDP11_RS13180 ENOG4105HHA aminodeoxychorismate lyase FDP11_RS13185 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FDP11_RS13190 ENOG4107QRG dna polymerase iii FDP11_RS13195 ENOG4105F8V Hydrolase, tatD family FDP11_RS13200 ENOG4105CI1 PTS System FDP11_RS13215 ENOG4105C8J )-transporter FDP11_RS13230 ENOG4108NRW Phospholipase, patatin family FDP11_RS13235 ENOG4105CA9 Pyruvate kinase FDP11_RS13240 ENOG4105DAG ROK family FDP11_RS13250 ENOG4105C0B DNA polymerase III (alpha subunit) FDP11_RS13265 ENOG4105UBK short-chain dehydrogenase reductase FDP11_RS13270 ENOG4105ERU peptidase FDP11_RS13275 ENOG4105CAT Cytidine monophosphate kinase FDP11_RS13280 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FDP11_RS13285 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FDP11_RS13290 ENOG4105Q4A inner membrane protein yciS FDP11_RS13295 ENOG4105CFV Tetratricopeptide repeat protein FDP11_RS13300 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FDP11_RS13305 ENOG4108J59 Extracellular solute-binding protein, family 5 FDP11_RS13315 ENOG4105CKK Glycosyl transferase, family 2 FDP11_RS13325 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FDP11_RS13335 ENOG4105DY2 Paraquat-inducible protein b FDP11_RS13340 ENOG4105F1S paraquat-inducible protein a FDP11_RS13345 ENOG4105NQN cytochrome C FDP11_RS13360 ENOG4106WHD Tetrathionate reductase FDP11_RS13365 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FDP11_RS13370 ENOG4106AFQ Histidine kinase FDP11_RS13375 ENOG4108ZXC Two component transcriptional regulator, luxr family FDP11_RS13380 ENOG4105EXG Transcriptional regulator FDP11_RS13390 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FDP11_RS13395 ENOG4105N6Y Thioredoxin FDP11_RS13410 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FDP11_RS13425 ENOG4105DJY efflux transporter, rnd family, mfp subunit FDP11_RS13435 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FDP11_RS13440 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FDP11_RS13445 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FDP11_RS13450 ENOG4108W2Y isochorismatase FDP11_RS13455 ENOG41063TF transcriptional regulator (AraC FDP11_RS13470 ENOG4105GFG DUF218 domain FDP11_RS13495 ENOG4105TMB Formate nitrite transporter FDP11_RS13505 ENOG4105C4B ABC transporter, permease FDP11_RS13520 ENOG4108J2R molybdopterin oxidoreductase FDP11_RS13535 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FDP11_RS13545 ENOG4108JQ2 peptide transport system atp-binding protein FDP11_RS13550 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FDP11_RS13555 ENOG4108EU3 peptide transport system, permease FDP11_RS13560 ENOG4108EKA peptide transport system, permease FDP11_RS13565 ENOG4108J59 Extracellular solute-binding protein, family 5 FDP11_RS13570 ENOG4105E51 psp operon transcriptional activator FDP11_RS13575 ENOG41087YS Phage shock protein A FDP11_RS13580 ENOG4105YYT phage shock protein B FDP11_RS13585 ENOG4105FM1 phage shock protein C FDP11_RS13590 ENOG410624X efflux transporter, rnd family, mfp subunit FDP11_RS13605 ENOG4108R3E Dna-3-methyladenine glycosylase i FDP11_RS13615 ENOG4107IFA Lipase (EC 3.1.1.3) FDP11_RS13620 ENOG4105C28 cystathionine FDP11_RS13625 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FDP11_RS13630 ENOG4105C8J )-transporter FDP11_RS13640 ENOG4108W1A pseudouridine synthase FDP11_RS13650 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FDP11_RS13655 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FDP11_RS13660 ENOG4108JUA Transcriptional regulator FDP11_RS13670 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FDP11_RS13675 ENOG4108VGW abc transporter atp-binding protein FDP11_RS13680 ENOG4105CXZ ABC transporter, permease FDP11_RS13685 ENOG4105VNH ABC transporter solute-binding protein FDP11_RS13690 ENOG4108RSN SNARE associated Golgi FDP11_RS13700 ENOG4105BZ8 glutamate synthase FDP11_RS13710 ENOG4106AFQ Histidine kinase FDP11_RS13715 ENOG4108ZXC Two component transcriptional regulator, luxr family FDP11_RS13725 ENOG4105XZD Fe-S protein FDP11_RS13735 ENOG4105CGH 5'-nucleotidase FDP11_RS13750 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FDP11_RS13755 ENOG4105EB3 Histidine kinase FDP11_RS13760 ENOG4105ETX regulatoR FDP11_RS13770 ENOG4105CFI type iii restriction protein res subunit FDP11_RS13775 ENOG4105I08 Pseudouridine synthase FDP11_RS13780 ENOG4105C2C drug resistance transporter, Bcr CflA FDP11_RS13810 ENOG4105CUW cytochrome C-TYPE protein FDP11_RS13815 ENOG4105CGD Nad-dependent epimerase dehydratase FDP11_RS13820 ENOG4107QI1 Mate efflux family protein FDP11_RS13825 ENOG4108I0Y (ABC) transporter FDP11_RS13840 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FDP11_RS13845 ENOG41067SE Tetr family transcriptional regulator FDP11_RS13850 ENOG4107QPN acyl-Coa dehydrogenase FDP11_RS13855 ENOG4105RKW reductase (By FDP11_RS13860 ENOG4105D0C transport protein FDP11_RS13865 ENOG41090BQ Glutaredoxin FDP11_RS13875 ENOG4106KNT transcriptional regulator FDP11_RS13880 ENOG4105DY8 decarboxylase FDP11_RS13890 ENOG4105DWU Membrane FDP11_RS13915 ENOG4105BZU Histidine kinase FDP11_RS13925 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FDP11_RS13930 ENOG4105BZC d-serine deaminase FDP11_RS13935 ENOG4108JJ8 (ABC) transporter FDP11_RS13940 ENOG4108JJ9 ABC, transporter FDP11_RS13945 ENOG4105C3M thioredoxin reductase FDP11_RS13970 ENOG4105C8P )-transporter FDP11_RS13975 ENOG4107GZ4 SanA protein FDP11_RS13980 ENOG4107R1I NAD-dependent malic enzyme FDP11_RS13985 ENOG4105CQ7 ATP-dependent helicase FDP11_RS13990 ENOG4105HDD phospholipase FDP11_RS14005 ENOG4105C8V SAICAR synthetase FDP11_RS14025 ENOG4105CDV Ompa motb domain protein FDP11_RS14040 ENOG4105CQB FAD linked oxidase domain protein FDP11_RS14055 ENOG4105C84 Histidine ammonia-lyase FDP11_RS14065 ENOG41088SP formiminoglutamate hydrolase FDP11_RS14070 ENOG4105CI2 imidazolone-5-propionate hydrolase FDP11_RS14075 ENOG4105CZE histidine utilization repressor FDP11_RS14090 ENOG4105C22 threonyL-tRNA synthetase FDP11_RS14095 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FDP11_RS14100 ENOG41082NX 50s ribosomal protein l35 FDP11_RS14105 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FDP11_RS14110 ENOG4105K8R UPF0145 protein FDP11_RS14140 ENOG4105BZU Histidine kinase FDP11_RS14145 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FDP11_RS14150 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FDP11_RS14160 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FDP11_RS14170 ENOG4105FQ6 thiopurine methyltransferase FDP11_RS14175 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FDP11_RS14180 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) FDP11_RS14185 ENOG41067MG lrgb family FDP11_RS14190 ENOG4105VAW lrga family FDP11_RS14195 ENOG4105CJB Exodeoxyribonuclease I FDP11_RS14200 ENOG4108ETY sodium dicarboxylate symporter FDP11_RS14205 ENOG4105K4T epimerase FDP11_RS14210 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FDP11_RS14215 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FDP11_RS14235 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FDP11_RS14240 ENOG4108IU2 vtamin B12-transporter permease FDP11_RS14245 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS14265 ENOG4107RSM transcriptional regulator FDP11_RS14275 ENOG4108VKG metal-dependent hydrolase FDP11_RS14280 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) FDP11_RS14310 ENOG4105CTU Proline racemase FDP11_RS14325 ENOG4105CIF Ornithine Cyclodeaminase FDP11_RS14330 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FDP11_RS14335 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS14340 ENOG4105F38 ABC transporter, permease FDP11_RS14345 ENOG4105D38 putrescine abc transporter FDP11_RS14355 ENOG4107MM9 BNR Asp-box repeat-containing protein FDP11_RS14365 ENOG4108JQ7 (ABC) transporter FDP11_RS14370 ENOG4105C3U ABC transporter FDP11_RS14375 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDP11_RS14380 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FDP11_RS14385 ENOG4107QSI ABC, transporter FDP11_RS14390 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FDP11_RS14395 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FDP11_RS14400 ENOG4105F1J Homogentisate 1,2-dioxygenase FDP11_RS14410 ENOG4108RXX maleylacetoacetate isomerase FDP11_RS14515 ENOG4105VEQ Cold shock protein FDP11_RS14520 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FDP11_RS14565 ENOG4108ES9 ParB domain protein nuclease FDP11_RS14575 ENOG4108N0N Phage Terminase Large Subunit FDP11_RS14725 ENOG4105N14 lysine exporter protein LysE YggA FDP11_RS14755 ENOG4105N14 lysine exporter protein LysE YggA FDP11_RS14780 ENOG4107S6Z Na H antiporter FDP11_RS14785 ENOG4105CFQ glutamine synthetase FDP11_RS14790 ENOG4108Z86 Glutamine amidotransferase FDP11_RS14795 ENOG4107VRI Transcriptional regulator FDP11_RS14800 ENOG4105C26 Dehydrogenase FDP11_RS14805 ENOG4105CJP fad dependent oxidoreductase FDP11_RS14815 ENOG4105DWY Agmatine deiminase FDP11_RS14820 ENOG4105C26 Dehydrogenase FDP11_RS14825 ENOG4108JPW Aminotransferase FDP11_RS14830 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FDP11_RS14835 ENOG4105BZU Histidine kinase FDP11_RS14845 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FDP11_RS14860 ENOG4108ZT1 Transcriptional regulator FDP11_RS14865 ENOG4105MSB protein, conserved in bacteria FDP11_RS14885 ENOG4108UW5 maltose o-acetyltransferase FDP11_RS14900 ENOG4105BZU Histidine kinase FDP11_RS14905 ENOG4105BZU Histidine kinase FDP11_RS14915 ENOG41090FY type IV pilus biogenesis stability protein PilW FDP11_RS14920 ENOG4105CVG Homoserine O-transsuccinylase FDP11_RS14930 ENOG4105E5D amino acid FDP11_RS14935 ENOG4105D1S lipid A biosynthesis FDP11_RS14940 ENOG4105CTD carboxy-peptidase FDP11_RS14945 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_RS14955 ENOG4105BZG amino acid carrier protein FDP11_RS14980 ENOG4105E0M Sulfatase FDP11_RS14985 ENOG4105DHQ Histidine kinase FDP11_RS15020 ENOG4105GIJ Glycine betaine FDP11_RS15025 ENOG4108HQS Glycine betaine FDP11_RS15030 ENOG4108IJ7 Glycine betaine FDP11_RS15045 ENOG4105C94 Transporter FDP11_RS15050 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase FDP11_RS15055 ENOG4108JPW Aminotransferase FDP11_RS15060 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FDP11_RS15065 ENOG4105CZK Aspartate kinase FDP11_RS15085 ENOG4105CA0 peroxidase FDP11_RS15100 ENOG4107V40 secretion protein, HlyD family FDP11_RS15115 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FDP11_RS15120 ENOG4108V9W transcriptional regulatory protein FDP11_RS15125 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FDP11_RS15130 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) FDP11_RS15135 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FDP11_RS15165 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FDP11_RS15170 ENOG4105C26 Dehydrogenase FDP11_RS15190 ENOG4108KB1 transcriptional regulator, arac family FDP11_RS15220 ENOG41066XE Type III export protein FDP11_RS15290 ENOG4105ENX hydrolase FDP11_RS15295 ENOG4105ENX hydrolase FDP11_RS15300 ENOG4105EQ2 LysR family Transcriptional regulator FDP11_RS15410 ENOG4105EJ9 Membrane FDP11_RS15440 ENOG4105CR4 methylisocitrate lyase FDP11_RS15445 ENOG4105BZN citrate synthase FDP11_RS15450 ENOG4108I0Z Aconitate hydratase FDP11_RS15455 ENOG4105C7F AcnD-accessory protein PrpF FDP11_RS15460 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FDP11_RS15470 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FDP11_RS15480 ENOG410667J hydrolase FDP11_RS15485 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FDP11_RS15490 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FDP11_RS15495 ENOG4105BZU Histidine kinase FDP11_RS15505 ENOG4105CDV Ompa motb domain protein FDP11_RS15520 ENOG4105CDV Ompa motb domain protein FDP11_RS15535 ENOG4105DR4 Methyltransferase FDP11_RS15540 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS15545 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FDP11_RS15550 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FDP11_RS15560 ENOG4108MN8 Membrane FDP11_RS15565 ENOG4105CDA abc transporter atp-binding protein FDP11_RS15570 ENOG4105DRP amino acid AbC transporter FDP11_RS15575 ENOG4105EZ7 amino acid ABC transporter FDP11_RS15580 ENOG4107QXX ABC transporter FDP11_RS15590 ENOG4108VPT UPF0234 protein FDP11_RS15595 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FDP11_RS15615 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FDP11_RS15620 ENOG4105DY2 Paraquat-inducible protein b FDP11_RS15625 ENOG4105H2K paraquat-inducible protein a FDP11_RS15630 ENOG4105BZ1 (ABC) transporter FDP11_RS15635 ENOG4108ZGC gaf domain protein FDP11_RS15640 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) FDP11_RS15645 ENOG4105CN1 protease FDP11_RS15655 ENOG4105CD8 aminopeptidase N FDP11_RS15665 ENOG4105C7I Dehydrogenase FDP11_RS15670 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FDP11_RS15675 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FDP11_RS15680 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FDP11_RS15690 ENOG4105C5H ABC transporter FDP11_RS15705 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FDP11_RS15710 ENOG4105DAN ATP-dependent protease FDP11_RS15715 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) FDP11_RS15780 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i FDP11_RS15795 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) FDP11_RS15805 ENOG4105C59 p-type ATPase FDP11_RS15820 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FDP11_RS15825 ENOG4105Q9Y Universal stress protein FDP11_RS15830 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FDP11_RS15850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS15860 ENOG4105D38 putrescine abc transporter FDP11_RS15865 ENOG4108HM4 ABC transporter FDP11_RS15870 ENOG4107RUE extracellular solute-binding protein family 1 FDP11_RS15875 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FDP11_RS15945 ENOG4105QAX Iron-sulfur FDP11_RS15950 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FDP11_RS15960 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) FDP11_RS15980 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FDP11_RS15985 ENOG4105C5H ABC transporter FDP11_RS15990 ENOG4105BZU Histidine kinase FDP11_RS15995 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_RS16010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS16015 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FDP11_RS16020 ENOG4105CVM Molybdenum cofactor synthesis domain protein FDP11_RS16030 ENOG4105CPK Glycosyl transferase (Group 1 FDP11_RS16035 ENOG4105CND Glycosyl transferase, family 2 FDP11_RS16050 ENOG4105C94 Transporter FDP11_RS16065 ENOG4105CQ7 ATP-dependent helicase FDP11_RS16070 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FDP11_RS16080 ENOG4108NEM leader-binding protein dmsD FDP11_RS16085 ENOG4107KGK dmso reductase anchor subunit FDP11_RS16090 ENOG4105QAX Iron-sulfur FDP11_RS16095 ENOG4107QY8 reductase FDP11_RS16125 ENOG4105BZU Histidine kinase FDP11_RS16135 ENOG4105CFG Acts as a chaperone (By similarity) FDP11_RS16140 ENOG4105CFG Acts as a chaperone (By similarity) FDP11_RS16165 ENOG4105BZ1 (ABC) transporter FDP11_RS16170 ENOG4105BZ1 (ABC) transporter FDP11_RS16190 ENOG4105E0U tyrosine-specific transport protein FDP11_RS16200 ENOG4105DHT Metal Dependent Phosphohydrolase FDP11_RS16210 ENOG4105EE5 Membrane protein terC FDP11_RS16220 ENOG41076CZ activating enzyme FDP11_RS16225 ENOG4105G0K glycine radical enzyme YjjI family FDP11_RS16230 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_RS16235 ENOG4105CPI Metal Dependent Phosphohydrolase FDP11_RS16240 ENOG4105BZU Histidine kinase FDP11_RS16245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_RS16250 ENOG4105BZU Histidine kinase FDP11_RS16255 ENOG4105C8P )-transporter FDP11_RS16285 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FDP11_RS16290 ENOG4106IUH DTW domain containing protein FDP11_RS16325 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS16330 ENOG4107TT5 NLP P60 protein FDP11_RS16340 ENOG4105BZU Histidine kinase FDP11_RS16345 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FDP11_RS16360 ENOG4108R6K riboflavin synthase, subunit alpha FDP11_RS16365 ENOG4107QI1 Mate efflux family protein FDP11_RS16380 ENOG41082AN stage II sporulation protein FDP11_RS16390 ENOG4107V1M polysaccharide export protein FDP11_RS16405 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_RS16415 ENOG4107TYR Glycosyl Transferase FDP11_RS16525 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FDP11_RS16670 ENOG4108MZY FDP11_RS16680 ENOG4108MR5 FDP11_RS16720 ENOG4105C0D helicase FDP11_RS16845 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FDP11_RS16900 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_RS16925 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FDP11_RS16980 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FDP11_RS17145 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FDP11_RS17280 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FDP11_RS17340 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FDP11_RS17525 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FDP11_RS17555 ENOG41067XF inhibitor FDP11_RS17635 ENOG4105KAF membrAne FDP11_RS17745 ENOG4108W0I acetyltransferase FDP11_RS17760 ENOG4105K8R UPF0145 protein FDP11_RS17785 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_RS17850 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FDP11_RS17905 ENOG4105C2X Arabinose 5-phosphate isomerase FDP11_RS18085 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FDP11_RS18305 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_RS18325 ENOG4105D9U N-acetyltransferase FDP11_RS18335 ENOG4106K28 UPF0283 membrane protein FDP11_RS18340 ENOG4105CM6 amino acid regulated cytosolic protein FDP11_RS18355 ENOG4105CRQ synthase (Component I) FDP11_RS18360 ENOG4105BZU Histidine kinase FDP11_RS18370 ENOG4105P8F nudix hydrolase FDP11_RS18375 ENOG4105C44 Serine transporter FDP11_RS18380 ENOG4105EJQ L-serine dehydratase FDP11_RS18385 ENOG4105BZU Histidine kinase FDP11_RS18395 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FDP11_RS18400 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS18405 ENOG4105C5S asparaginyl-tRNA synthetase FDP11_RS18415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDP11_RS18430 ENOG4105CGF Aromatic amino acid aminotransferase FDP11_RS18450 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS18455 ENOG4105C94 Transporter FDP11_RS18460 ENOG41067TZ transcriptional regulator, MarR family FDP11_RS18475 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FDP11_RS18485 ENOG4105CH5 extracellular solute-binding protein, family 7 FDP11_RS18500 ENOG4105C5X domain protein FDP11_RS18505 ENOG4105EAQ (twin-arginine translocation) pathway signal FDP11_RS18510 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FDP11_RS18535 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FDP11_RS18545 ENOG4108DMF Cytochrome C biogenesis protein FDP11_RS18550 ENOG4107QX9 Thiol disulfide interChange protein FDP11_RS18555 ENOG4105DA4 cytochrome c-type biogenesis protein FDP11_RS18560 ENOG4105DVI reductase, NrfD FDP11_RS18565 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FDP11_RS18575 ENOG4105EAU Plays a role in nitrite reduction (By similarity) FDP11_RS18590 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDP11_RS18595 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FDP11_RS18600 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FDP11_RS18605 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FDP11_RS18630 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) FDP11_RS18670 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FDP11_RS18675 ENOG4105WH1 Two component transcriptional regulator luxr family FDP11_RS18680 ENOG4105CQ2 DNA polymerase FDP11_RS18690 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FDP11_RS18695 ENOG4108W5H UPF0263 protein FDP11_RS18700 ENOG4105FE9 pseudouridine synthase FDP11_RS18710 ENOG4107RTD sua5 ycio yrdc ywlc family protein FDP11_RS18715 ENOG4105DB7 PHP domain protein FDP11_RS18725 ENOG4105CRQ synthase (Component I) FDP11_RS18730 ENOG4105DDQ anthranilate synthase FDP11_RS18735 ENOG4108I0Q anthranilate phosphoribosyltransferase FDP11_RS18740 ENOG4105DK0 Indole-3-glycerol phosphate synthase FDP11_RS18745 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FDP11_RS18750 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FDP11_RS18755 ENOG4107RYR Transcriptional regulator, Crp Fnr family FDP11_RS18760 ENOG4105CEY Amp-dependent synthetase and ligase FDP11_RS18765 ENOG4105CK2 sodium dicarboxylate symporter FDP11_RS18775 ENOG4105BZU Histidine kinase FDP11_RS18785 ENOG4107835 probably involved in intracellular septation (By similarity) FDP11_RS18790 ENOG4105NAU thioesterase Superfamily protein FDP11_RS18795 ENOG4105K9H YciI-like protein FDP11_RS18805 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FDP11_RS18810 ENOG4105DZ2 Transcriptional regulator FDP11_RS18830 ENOG4105CCT upf0313 protein FDP11_RS18835 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS18840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDP11_RS18845 ENOG41062D9 Histidine kinase FDP11_RS18865 ENOG4105JQN Transcriptional regulator FDP11_RS18870 ENOG4105J12 Multidrug resistance protein mdtN FDP11_RS18885 ENOG4107104 thymidine kinase FDP11_RS18890 ENOG4105C8N cysteinyl-tRNA synthetase FDP11_RS18895 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FDP11_RS18900 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FDP11_RS18905 ENOG4105D58 Diguanylate phosphodiesterase FDP11_RS18910 ENOG4105K5B UPF0225 protein FDP11_RS18915 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FDP11_RS18920 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FDP11_RS18930 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FDP11_RS18935 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FDP11_RS18940 ENOG4105CIH Imidazole acetol-phosphate transaminase FDP11_RS18945 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FDP11_RS18950 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FDP11_RS18955 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_RS18965 ENOG4107S6Z Na H antiporter FDP11_RS18970 ENOG4108YX2 DNA-binding protein FDP11_RS18975 ENOG4107RE1 Inosine-guanosine kinase FDP11_RS18985 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FDP11_RS18990 ENOG41075W9 High frequency lysogenization protein HflD homolog FDP11_RS18995 ENOG4107QTF adenylosuccinate lyase FDP11_RS19015 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FDP11_RS19030 ENOG4107FW0 short-chain dehydrogenase reductase FDP11_RS19040 ENOG4105D0M Protease HtpX homolog FDP11_RS19050 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FDP11_RS19060 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FDP11_RS19065 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FDP11_RS19070 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FDP11_RS19075 ENOG4105KSC Transcriptional regulator, TraR DksA family FDP11_RS19085 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FDP11_RS19090 ENOG4105D1H recombination factor protein RarA FDP11_RS19095 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FDP11_RS19100 ENOG4105CNU cell division protein FtsK FDP11_RS19105 ENOG4105EW9 transcriptional regulator AsnC family FDP11_RS19110 ENOG4105DCF alanine dehydrogenase FDP11_RS19120 ENOG4107R11 Transcriptional regulator FDP11_RS19130 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FDP11_RS19160 ENOG4105BZS acriflavin resistance protein FDP11_RS19165 ENOG4105C1P efflux transporter, rnd family, mfp subunit FDP11_RS19170 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS19180 ENOG4108RNS Exports L-alanine (By similarity) FDP11_RS19185 ENOG4105BZU Histidine kinase FDP11_RS19195 ENOG4106032 Glutathionylspermidine synthase FDP11_RS19205 ENOG4105Z6B inner membrane protein yjfl FDP11_RS19215 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FDP11_RS19225 ENOG4107R28 alpha amylase, catalytic region FDP11_RS19230 ENOG4108JJB ABC transporter FDP11_RS19235 ENOG4105C7J ABC transporter, permease FDP11_RS19245 ENOG4105PQ6 UPF0208 membrane protein FDP11_RS19250 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FDP11_RS19255 ENOG4108DNC Involved in acetate metabolism (By similarity) FDP11_RS19260 ENOG4107PU6 Membrane FDP11_RS19270 ENOG4105CHF Glutathione S-transferase FDP11_RS19275 ENOG4108JQ7 (ABC) transporter FDP11_RS19280 ENOG4105C3U ABC transporter FDP11_RS19285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDP11_RS19290 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FDP11_RS19295 ENOG4107QSI ABC, transporter FDP11_RS19300 ENOG4108ZAF Molybdopterin FDP11_RS19305 ENOG4105M00 molybdopterin converting factor, subunit 1 FDP11_RS19310 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FDP11_RS19315 ENOG4108RIR Molybdenum cofactor biosynthesis protein FDP11_RS19320 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FDP11_RS19325 ENOG4105CHW UPF0052 protein FDP11_RS19335 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_RS19340 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FDP11_RS19360 ENOG4105DSP amino acid AbC transporter FDP11_RS19365 ENOG4105E89 ABC transporter FDP11_RS19370 ENOG4108JEH abc transporter atp-binding protein FDP11_RS19385 ENOG4105C6N Formate acetyltransferase FDP11_RS19395 ENOG4105F1A Pyruvate formate-lyase FDP11_RS19405 ENOG4105XWI UPF0304 protein FDP11_RS19410 ENOG4105CYN Serine protein kinase FDP11_RS19415 ENOG4106AKX UPF0229 protein FDP11_RS19420 ENOG4105ED1 spovr family FDP11_RS19425 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FDP11_RS19430 ENOG4105W49 UPF0434 protein FDP11_RS19435 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FDP11_RS19440 ENOG4105BZ1 (ABC) transporter FDP11_RS19445 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FDP11_RS19455 ENOG4105D60 lipoprotein releasing system transmembrane protein FDP11_RS19460 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FDP11_RS19465 ENOG4105D60 lipoprotein releasing system transmembrane protein FDP11_RS19475 ENOG4108JA2 transcriptioN-repair coupling factor FDP11_RS19490 ENOG4105CEP NADH dehydrogenase FDP11_RS19495 ENOG4105D0Y UPF0227 protein FDP11_RS19520 ENOG4105K59 histidine triad (HIT) protein FDP11_RS19525 ENOG4108NVR Methyl-accepting chemotaxis FDP11_RS19535 ENOG4107SXA Phosphorylase FDP11_RS19545 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FDP11_RS19550 ENOG4105DZ0 fad dependent oxidoreductase FDP11_RS19555 ENOG4108Z4U Ferredoxin FDP11_RS19570 ENOG4108KHX Diguanylate cyclase FDP11_RS19585 ENOG4108MNP Glycoprotein polysaccharide metabolism FDP11_RS19590 ENOG4105C29 acyl-CoA thioesterase FDP11_RS19600 ENOG4108XM1 transcriptional regulator AsnC family FDP11_RS19625 ENOG4105BZS acriflavin resistance protein FDP11_RS19630 ENOG4105ENT Efflux transporter rnd family, mfp subunit FDP11_RS19675 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FDP11_RS19680 ENOG4105HMI Membrane FDP11_RS19690 ENOG4105CEY Amp-dependent synthetase and ligase FDP11_RS19700 ENOG4108IPT Naphthoate synthase FDP11_RS19705 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FDP11_RS19710 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FDP11_RS19715 ENOG4105E4F Isochorismate synthase FDP11_RS19720 ENOG4105CHM Aminotransferase FDP11_RS19725 ENOG4105DK2 UPF0207 protein FDP11_RS19730 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FDP11_RS19745 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FDP11_RS19750 ENOG4105EIN peptidylprolyl cis-trans isomerase FDP11_RS19755 ENOG4105K70 DNA-binding protein FDP11_RS19760 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FDP11_RS19765 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FDP11_RS19770 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FDP11_RS19775 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FDP11_RS19785 ENOG4105CQZ Histidine kinase FDP11_RS19800 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FDP11_RS19805 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ FDP11_RS19810 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FDP11_RS19815 ENOG4105CNG UPF0061 protein FDP11_RS19835 ENOG4107ZYR domain protein FDP11_RS19840 ENOG4105C1J atp-dependent rna helicase FDP11_RS19855 ENOG4107T3I fad-binding protein FDP11_RS19880 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FDP11_RS19900 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FDP11_RS19905 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FDP11_RS19910 ENOG4105C84 Histidine ammonia-lyase FDP11_RS19935 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FDP11_RS19945 ENOG4105C2D reductase FDP11_RS19950 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FDP11_RS19960 ENOG4105DFP Integrase FDP11_RS19965 ENOG4105CAF HipA N-terminal domain protein FDP11_RS19970 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein FDP11_RS20045 ENOG4107QTH restriction modification system DNA specificity domain FDP11_RS20080 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FDP11_RS20085 ENOG4105D9N nucleoside FDP11_RS20090 ENOG4105CC0 LysR family Transcriptional regulator FDP11_RS20095 ENOG4105CVE Lytic murein transglycosylase FDP11_RS20100 ENOG4105VNG YcgL domain-containing protein FDP11_RS20105 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FDP11_RS20110 ENOG4107QMS site-determining protein FDP11_RS20115 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FDP11_RS20120 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FDP11_RS20125 ENOG4105CEY Amp-dependent synthetase and ligase FDP11_RS20130 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FDP11_RS20145 ENOG41072GX Peptidase M22 Glycoprotease FDP11_RS20150 ENOG4105DVT helicase FDP11_RS20155 ENOG4105CIY formyltetrahydrofolate deformylase FDP11_RS20160 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FDP11_RS20170 ENOG4106ZCM YecM protein FDP11_RS20175 ENOG4105C75 arginyL-tRNA synthetase FDP11_RS20190 ENOG4105CE1 Ferrous iron transport protein b FDP11_RS20195 ENOG4105XFK Ferrous iron transport protein A FDP11_RS20200 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FDP11_RS20205 ENOG4105NXV High-affinity zinc uptake system protein FDP11_RS20210 ENOG4105FDK ABC transporter FDP11_RS20215 ENOG4105FAV ABC, transporter FDP11_RS20220 ENOG4105E7A Glutamine amidotransferase FDP11_RS20225 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FDP11_RS20230 ENOG4107QPN acyl-Coa dehydrogenase FDP11_RS20240 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FDP11_RS20260 ENOG4107RZZ dna polymerase iii epsilon subunit FDP11_RS20265 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FDP11_RS20270 ENOG4105D1A Methyltransferase FDP11_RS20275 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FDP11_RS20280 ENOG4105E9H Lytic Murein transglycosylase FDP11_RS20290 ENOG4107NA1 Endonuclease Exonuclease phosphatase FDP11_RS20295 ENOG4108YZA Nitrogen regulatory protein pii FDP11_RS20305 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FDP11_RS20310 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FDP11_RS20315 ENOG4105C0B DNA polymerase III (alpha subunit) FDP11_RS20320 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FDP11_RS20325 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FDP11_RS20330 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FDP11_RS20335 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FDP11_RS20340 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FDP11_RS20345 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FDP11_RS20355 ENOG4105DZP Membrane-associated zinc metalloprotease FDP11_RS20360 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FDP11_RS20365 ENOG4105KNE Phosphatidate cytidylyltransferase FDP11_RS20370 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FDP11_RS20375 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FDP11_RS20380 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FDP11_RS20385 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FDP11_RS20390 ENOG4105CE9 30S ribosomal protein S2 FDP11_RS20395 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FDP11_RS20400 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FDP11_RS20405 ENOG4108T8E UPF0325 protein FDP11_RS20410 ENOG4105DR9 pseudouridine synthase FDP11_RS20415 ENOG4105WP7 tRNA pseudouridine synthase C FDP11_RS20440 ENOG4108UPT UPF0178 protein FDP11_RS20445 ENOG4105CFC Transporter FDP11_RS20455 ENOG4105NRA 50s ribosomal protein l31 type b FDP11_RS20460 ENOG4108R96 Methyltransferase, YaeB family FDP11_RS20465 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FDP11_RS20475 ENOG4105W1I UPF0253 protein FDP11_RS20485 ENOG4105C8J )-transporter FDP11_RS20500 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FDP11_RS20505 ENOG4105C9U ATP-dependent DNA helicase RecQ FDP11_RS20510 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FDP11_RS20525 ENOG4105CJ2 (LipO)protein FDP11_RS20530 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) FDP11_RS20535 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FDP11_RS20540 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FDP11_RS20545 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FDP11_RS20550 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FDP11_RS20555 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FDP11_RS20560 ENOG4105M85 Bola protein FDP11_RS20565 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FDP11_RS20570 ENOG4105IEY (LipO)protein FDP11_RS20575 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FDP11_RS20590 ENOG4105K6V RNA polymerase FDP11_RS20610 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FDP11_RS20615 ENOG4107S0N DJ-1 family FDP11_RS20620 ENOG4105C9B Cysteine desulfurase FDP11_RS20625 ENOG4105BZU Histidine kinase FDP11_RS20630 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FDP11_RS20635 ENOG4105CUZ uba thif-type nad fad binding protein FDP11_RS20640 ENOG4105CA3 membrane-bound lytic murein transglycosylase FDP11_RS20650 ENOG4107QZM n-acetylglutamate synthase FDP11_RS20670 ENOG4107QYX exodeoxyribonuclease v alpha FDP11_RS20675 ENOG4107QKA exodeoxyribonuclease V beta FDP11_RS20680 ENOG4105DSY exodeoxyribonuclease V, gamma FDP11_RS20685 ENOG4105E68 Sulfatase FDP11_RS20695 ENOG4105EVZ LysR family transcriptional regulator FDP11_RS20700 ENOG4105X2V dna damage-inducible protein FDP11_RS20705 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) FDP11_RS20710 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FDP11_RS20715 ENOG4105CXY transporter FDP11_RS20720 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FDP11_RS20725 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FDP11_RS20730 ENOG4105E98 transcriptional regulator DeoR family FDP11_RS20735 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FDP11_RS20740 ENOG4107RX3 Mg2 transporter protein cora family protein FDP11_RS20755 ENOG4108Y51 tRNA-binding protein FDP11_RS20760 ENOG41060NJ transcriptional regulator FDP11_RS20765 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FDP11_RS20780 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FDP11_RS20785 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FDP11_RS20790 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FDP11_RS20795 ENOG4105CMR udp-glucose 4-epimerase FDP11_RS20800 ENOG4105CQ4 Transcriptional regulator FDP11_RS20805 ENOG4105CNT hydrolase family 2 FDP11_RS20810 ENOG4105FK9 beta-D-galactosidase beta subunit FDP11_RS20815 ENOG4105E5D amino acid FDP11_RS20820 ENOG41064T2 transcriptional regulator, lysR family FDP11_RS20910 ENOG4108IQE Amp-dependent synthetase and ligase FDP11_RS20920 ENOG4105ETT transcriptional Regulator, LysR family FDP11_RS20925 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FDP11_RS20930 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FDP11_RS20940 ENOG4105EAC phosphoserine phosphatase FDP11_RS20950 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FDP11_RS20955 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FDP11_RS20960 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FDP11_RS20965 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FDP11_RS20970 ENOG4105D9N nucleoside FDP11_RS20975 ENOG4105EYA deoxyribonuclease FDP11_RS20985 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FDP11_RS21005 ENOG4108YYD acetyltransferase FDP11_RS21015 ENOG4105BZU Histidine kinase FDP11_RS21030 ENOG4105C3S Mate efflux family protein FDP11_RS21045 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FDP11_RS21050 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FDP11_RS21055 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FDP11_RS21060 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FDP11_RS21065 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FDP11_RS21070 ENOG4105CHV Transcription elongation factor NusA FDP11_RS21075 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FDP11_RS21090 ENOG4105NTZ Preprotein translocase subunit SecG FDP11_RS21095 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FDP11_RS21100 ENOG4105EEI dihydropteroate synthase FDP11_RS21105 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FDP11_RS21110 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FDP11_RS21115 ENOG4105HBR Rna-binding protein FDP11_RS21120 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FDP11_RS21125 ENOG4107QE9 Inherit from COG: Membrane FDP11_RS21130 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FDP11_RS21140 ENOG4108Z6B deaminase FDP11_RS21145 ENOG4105CFC Transporter FDP11_RS21175 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FDP11_RS21180 ENOG4105CFG Acts as a chaperone (By similarity) FDP11_RS21190 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FDP11_RS21195 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FDP11_RS21205 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FDP11_RS21210 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FDP11_RS21215 ENOG4105VDB UPF0125 protein FDP11_RS21220 ENOG4108Z1B Cyclase dehydrase FDP11_RS21225 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FDP11_RS21265 ENOG4105CVR type I restriction-modification system FDP11_RS21285 ENOG4105ETT transcriptional Regulator, LysR family FDP11_RS21290 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FDP11_RS21310 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FDP11_RS21315 ENOG4108IQK o-acetylhomoserine FDP11_RS21340 ENOG4105MWK D-amino acid dehydrogenase, small subunit FDP11_RS21345 ENOG4105BZG amino acid carrier protein FDP11_RS21355 ENOG4106HK8 GPR1 FUN34 yaaH family protein FDP11_RS21365 ENOG4107S6Z Na H antiporter FDP11_RS21370 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FDP11_RS21375 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FDP11_RS21380 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FDP11_RS21395 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FDP11_RS21400 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FDP11_RS21405 ENOG4105N21 Membrane FDP11_RS21410 ENOG4105CUT histidyl-tRNA synthetase FDP11_RS21415 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FDP11_RS21425 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FDP11_RS21430 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FDP11_RS21435 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FDP11_RS21440 ENOG4105WVQ Fe-S assembly protein IscX FDP11_RS21445 ENOG4108ZIT Ferredoxin, 2FE-2S FDP11_RS21450 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FDP11_RS21455 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) FDP11_RS21460 ENOG4108Z4V iron-sulfur cluster assembly FDP11_RS21465 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FDP11_RS21470 ENOG4105C3J Cysteine desulfurase FDP11_RS21475 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FDP11_RS21480 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FDP11_RS21485 ENOG4105ECY inositol monophosphatase FDP11_RS21490 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FDP11_RS21495 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FDP11_RS21500 ENOG4105VIE preprotein translocase, subunit YajC FDP11_RS21505 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FDP11_RS21510 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FDP11_RS21520 ENOG4105W87 Cbs domain FDP11_RS21525 ENOG4108I9X Isocitrate lyase FDP11_RS21530 ENOG4107QP3 malate synthase g FDP11_RS21535 ENOG4105C5Q Transcriptional regulator FDP11_RS21540 ENOG4105D3R alkyl hydroperoxide reductase FDP11_RS21545 ENOG4106N3A copper homeostasis protein cutc FDP11_RS21550 ENOG4105CSR polyphosphate kinase 2 FDP11_RS21560 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FDP11_RS21565 ENOG4105E2Z phosphate ABC transporter (Permease FDP11_RS21570 ENOG4105C8U phosphate abc transporter FDP11_RS21575 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FDP11_RS21580 ENOG4105C9X ppx gppa phosphatase FDP11_RS21585 ENOG4105DJH phosphate FDP11_RS21590 ENOG4105BZU Histidine kinase FDP11_RS21595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDP11_RS21600 ENOG4105DH7 May be involved in recombination (By similarity) FDP11_RS21605 ENOG4105CFP Peptidase U32 FDP11_RS21610 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FDP11_RS21665 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FDP11_RS21670 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FDP11_RS21675 ENOG4105C34 Pseudouridine synthase FDP11_RS21680 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FDP11_RS21685 ENOG4105E4C Lytic transglycosylase catalytic FDP11_RS21690 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FDP11_RS21700 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FDP11_RS21705 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) FDP11_RS21710 ENOG4107SC1 transglycosylase FDP11_RS21715 ENOG4105C5H ABC transporter FDP11_RS21725 ENOG4105DR5 peptidase FDP11_RS21730 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FDP11_RS21735 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FDP11_RS21740 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) FDP11_RS21745 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FDP11_RS21750 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FDP11_RS21770 ENOG4108HRK Histidine kinase FDP11_RS21775 ENOG4108NEV two component transcriptional regulator, LytTR family FDP11_RS21780 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FDP11_RS21785 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FDP11_RS21790 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FDP11_RS21795 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FDP11_RS21800 ENOG4105DTN riboflavin biosynthesis protein ribF FDP11_RS21805 ENOG4105CJR Integral membrane protein (MviN FDP11_RS21810 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FDP11_RS21815 ENOG41080HT Transcriptional regulator, arsr family FDP11_RS21820 ENOG41063Z6 transcriptional regulator, lysR family FDP11_RS21835 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FDP11_RS21840 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FDP11_RS21845 ENOG4105HF0 Membrane FDP11_RS21850 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FDP11_RS21855 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FDP11_RS21860 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) FDP11_RS21870 ENOG4105CPC Aldo Keto reductase FDP11_RS21880 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_RS21885 ENOG4105CRK lysyL-tRNA synthetase FDP11_RS21895 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FDP11_RS21900 ENOG4105T95 Thiol disulfide interChange protein FDP11_RS21910 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FDP11_RS21915 ENOG4105CWM branched-chain amino acid transport system II carrier protein FDP11_RS21920 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FDP11_RS21925 ENOG4105C1J atp-dependent rna helicase FDP11_RS21930 ENOG4105D1Q UPF0246 protein FDP11_RS21935 ENOG4105BZG amino acid carrier protein FDP11_RS21950 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FDP11_RS21955 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FDP11_RS21960 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) FDP11_RS21965 ENOG4105D98 threonine synthase FDP11_RS21970 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FDP11_RS21985 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FDP11_RS21995 ENOG41065U4 response regulator FDP11_RS22005 ENOG4105BZU Histidine kinase FDP11_RS22015 ENOG4105N5T Radical SAM Protein FDP11_RS22030 ENOG4105CBC glutamate synthase FDP11_RS22035 ENOG4105BZ8 glutamate synthase FDP11_RS22045 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FDP11_RS22050 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FDP11_RS22055 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FDP11_RS22060 ENOG4105EN6 Membrane FDP11_RS22065 ENOG4105VP0 transcriptional regulator, lysR family FDP11_RS22080 ENOG4105EJ9 Membrane FDP11_RS22095 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FDP11_RS22100 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FDP11_RS22105 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FDP11_RS22110 ENOG4105M6F mutator MutT protein FDP11_RS22115 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FDP11_RS22125 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FDP11_RS22130 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FDP11_RS22135 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FDP11_RS22140 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FDP11_RS22145 ENOG4105DFU Cell wall formation (By similarity) FDP11_RS22150 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FDP11_RS22160 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FDP11_RS22165 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FDP11_RS22170 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FDP11_RS22175 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FDP11_RS22180 ENOG4105CJN penicillin-binding protein FDP11_RS22185 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FDP11_RS22190 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FDP11_RS22200 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FDP11_RS22210 ENOG41082RQ UPF0102 protein FDP11_RS22215 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FDP11_RS22220 ENOG4105W4M Transport-associated protein FDP11_RS22225 ENOG4105KB2 stringent starvation protein b FDP11_RS22230 ENOG4107MKT Stringent starvation protein a FDP11_RS22235 ENOG4105EIX cytochrome c1 FDP11_RS22240 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FDP11_RS22245 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FDP11_RS22250 ENOG4108UJD 30S ribosomal protein S9 FDP11_RS22255 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FDP11_RS22260 ENOG4105D6Z AFG1 family ATPase FDP11_RS22265 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FDP11_RS22270 ENOG4105C0H protease FDP11_RS22275 ENOG4105C0H protease FDP11_RS22280 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDP11_RS22285 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDP11_RS22290 ENOG4105IPS esterase FDP11_RS22295 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FDP11_RS22300 ENOG4108SX3 cytoplasmic protein FDP11_RS22305 ENOG41087AY ADP-Ribose pyrophosphatase FDP11_RS22310 ENOG4105DFG type I secretion outer membrane protein FDP11_RS22315 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FDP11_RS22320 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FDP11_RS22325 ENOG4108NVR Methyl-accepting chemotaxis FDP11_RS22335 ENOG4105I7R Adenylate cyclase FDP11_RS22340 ENOG4107IX6 phosphate transport regulator FDP11_RS22345 ENOG4105CJ3 phosphate transporter FDP11_RS22350 ENOG4106MWK domain protein FDP11_RS22365 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FDP11_RS22370 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FDP11_RS22375 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FDP11_RS22380 ENOG4107ZVW dihydroneopterin aldolase FDP11_RS22385 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FDP11_RS22390 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FDP11_RS22395 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FDP11_RS22400 ENOG4105VCC 30S ribosomal protein S21 FDP11_RS22405 ENOG4105KTH gatB Yqey FDP11_RS22410 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FDP11_RS22415 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDP11_RS22425 ENOG4105DFP Integrase FDP11_RS22440 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FDP11_RS22460 ENOG4108YGG dna repair protein FDP11_RS22500 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FDP11_RS22520 ENOG4105JXR Protein of unknown function (DUF3296) FDP11_RS22530 ENOG4105D01 (LipO)protein FDP11_RS22560 ENOG4105CTS PTS system mannitol-specific FDP11_RS22565 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FDP11_RS22570 ENOG4105E61 Mannitol repressor protein FDP11_RS22575 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 FDP11_RS22580 ENOG4105GR3 Histidine kinase FDP11_RS22595 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FDP11_RS22600 ENOG410804X Transcriptional regulator FDP11_RS22605 ENOG4105CA9 Pyruvate kinase FDP11_RS22615 ENOG4105BZU Histidine kinase FDP11_RS22620 ENOG4108ZP8 Acetolactate synthase small subunit FDP11_RS22625 ENOG4105C7K acetolactate synthase FDP11_RS22630 ENOG4108IQE Amp-dependent synthetase and ligase FDP11_RS22635 ENOG41064T2 transcriptional regulator, lysR family FDP11_RS22655 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FDP11_RS22660 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FDP11_RS22665 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FDP11_RS22670 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FDP11_RS22680 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FDP11_RS22685 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FDP11_RS22690 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FDP11_RS22695 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FDP11_RS22700 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FDP11_RS22705 ENOG4105NWN ApaG protein FDP11_RS22710 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FDP11_RS22715 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FDP11_RS22725 ENOG4105DWK Membrane FDP11_RS22730 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FDP11_RS22735 ENOG4105K46 50S ribosomal protein l27 FDP11_RS22740 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FDP11_RS22745 ENOG4105EAH synthase FDP11_RS22755 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FDP11_RS22760 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) FDP11_RS22765 ENOG4105H1G trap transporter solute receptor taxi family FDP11_RS22780 ENOG4107T0D ABC, transporter FDP11_RS22785 ENOG4106SMU thiamine transporter membrane protein FDP11_RS22790 ENOG4105DP9 ABC transporter FDP11_RS22795 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FDP11_RS22800 ENOG4105DFU Cell wall formation (By similarity) FDP11_RS22805 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FDP11_RS22810 ENOG4105F0N pyrophosphate phospho-hydrolase FDP11_RS22820 ENOG41066HZ AIG2-like family FDP11_RS22825 ENOG4105MA0 exported protein FDP11_RS22830 ENOG4105CFU surface antigen FDP11_RS22835 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FDP11_RS22840 ENOG41061GZ Protein of unknown function (DUF1107) FDP11_RS22845 ENOG4108UUE Transcriptional regulator FDP11_RS22860 ENOG4108I0Y (ABC) transporter FDP11_RS22880 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FDP11_RS22890 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FDP11_RS22895 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FDP11_RS22900 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FDP11_RS22905 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FDP11_RS22915 ENOG4105C1J atp-dependent rna helicase FDP11_RS22920 ENOG4107YB6 acetyltransferase, (GNAT) family FDP11_RS22930 ENOG4108V1T peptidylprolyl cis-trans isomerase FDP11_RS22940 ENOG4108ZT0 50S ribosomal protein l17 FDP11_RS22945 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDP11_RS22950 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FDP11_RS22955 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FDP11_RS22960 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FDP11_RS22970 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FDP11_RS22975 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FDP11_RS22980 ENOG4105VPB 50S ribosomal protein L30 FDP11_RS22985 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FDP11_RS22995 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FDP11_RS23000 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FDP11_RS23005 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FDP11_RS23010 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FDP11_RS23015 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FDP11_RS23020 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FDP11_RS23025 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FDP11_RS23030 ENOG41083MP 50s ribosomal protein l29 FDP11_RS23035 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FDP11_RS23040 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FDP11_RS23045 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FDP11_RS23050 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FDP11_RS23055 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FDP11_RS23060 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FDP11_RS23065 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FDP11_RS23070 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FDP11_RS23075 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FDP11_RS23080 ENOG4105VFB Binds the 23S rRNA (By similarity) FDP11_RS23085 ENOG4105C25 Primosomal protein n' FDP11_RS23090 ENOG4105ETE Transcriptional regulator (LacI family FDP11_RS23100 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FDP11_RS23105 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FDP11_RS23110 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FDP11_RS23115 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FDP11_RS23120 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) FDP11_RS23125 ENOG4105CBT Fructose-1,6-bisphosphatase FDP11_RS23150 ENOG4105CP7 Triose-phosphate isomerase FDP11_RS23155 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FDP11_RS23225 ENOG4105FGF GDP-mannose mannosyl hydrolase FDP11_RS23230 ENOG4105C30 Nad-dependent epimerase dehydratase FDP11_RS23235 ENOG4105C0K Gdp-mannose 4,6-dehydratase FDP11_RS23250 ENOG4105C2X Arabinose 5-phosphate isomerase FDP11_RS23255 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FDP11_RS23260 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FDP11_RS23285 ENOG4107QKV phosphomannomutase FDP11_RS23290 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FDP11_RS23300 ENOG4105C1B dTDP-glucose 4-6-dehydratase FDP11_RS23310 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FDP11_RS23330 ENOG41090SZ ABC-2 type transporter FDP11_RS23335 ENOG4107V1M polysaccharide export protein FDP11_RS23340 ENOG4105ESV Glycosyl transferase, family 4 FDP11_RS23370 ENOG4105UV2 general secretion pathway protein K FDP11_RS23390 ENOG4105D7Q type ii secretion system FDP11_RS23395 ENOG4107QHF type ii secretion system protein e FDP11_RS23400 ENOG4108VAU general secretion pathway protein G FDP11_RS23410 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FDP11_RS23415 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) FDP11_RS23425 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FDP11_RS23430 ENOG4105ESV Glycosyl transferase, family 4 FDP11_RS23440 ENOG4108MDC (LipO)protein FDP11_RS23450 ENOG4105E3R (LipO)protein FDP11_RS23455 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FDP11_RS23460 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FDP11_RS23465 ENOG4105XA0 heptosyltransferase ii FDP11_RS23470 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FDP11_RS23480 ENOG4105F0R Cytidylyltransferase FDP11_RS23495 ENOG4105D2T synthase FDP11_RS23500 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase FDP11_RS23505 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FDP11_RS23515 ENOG4105D7W serine acetyltransferase FDP11_RS23530 ENOG4105E68 Sulfatase FDP11_RS23540 ENOG41080IJ Diacylglycerol kinase FDP11_RS23545 ENOG4105DKP glycosyl transferase, family 9 FDP11_RS23550 ENOG4106WTF Glycosyl transferase, family 2 FDP11_RS23555 ENOG4107T8Q Glycosyl transferase (Group 1 FDP11_RS23560 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FDP11_RS23570 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FDP11_RS23585 ENOG4105KDC 50s ribosomal protein l28 FDP11_RS23590 ENOG4105W5Q DNA repair protein (RadC FDP11_RS23595 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_RS23600 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FDP11_RS23605 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FDP11_RS23610 ENOG4105D1S lipid A biosynthesis FDP11_RS23615 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FDP11_RS23620 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FDP11_RS23625 ENOG4105DSJ YicC domain protein FDP11_RS23635 ENOG4108JQ7 (ABC) transporter FDP11_RS23645 ENOG4107QRA Extracellular solute-binding protein, family 5 FDP11_RS23650 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FDP11_RS23655 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FDP11_RS23680 ENOG4109015 Biopolymer transport protein exbD tolR FDP11_RS23695 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FDP11_RS23700 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FDP11_RS23705 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FDP11_RS23710 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FDP11_RS23715 ENOG4105CB5 ATP-dependent DNA helicase recG FDP11_RS23720 ENOG4105C2W permease FDP11_RS23725 ENOG4105E0F Histidine kinase FDP11_RS23740 ENOG4108RRZ Transcription elongation factor GreB FDP11_RS23750 ENOG4105BZM domain protein FDP11_RS23760 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FDP11_RS23765 ENOG4105MJ2 Competence protein FDP11_RS23770 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) FDP11_RS23775 ENOG4107RK2 ADP-ribose diphosphatase NudE FDP11_RS23780 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FDP11_RS23785 ENOG4105PIC general secretion pathway protein N FDP11_RS23790 ENOG4105U1E general secretion pathway protein M FDP11_RS23795 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) FDP11_RS23800 ENOG4108RTD type II secretion system protein K FDP11_RS23805 ENOG4108WWZ General secretion pathway protein J FDP11_RS23810 ENOG4105X5Z General secretion pathway protein I FDP11_RS23815 ENOG4105VWV general secretion pathway protein h FDP11_RS23820 ENOG4108VAU general secretion pathway protein G FDP11_RS23825 ENOG4105D7Q type ii secretion system FDP11_RS23830 ENOG4107QHF type ii secretion system protein e FDP11_RS23840 ENOG4108XKW General secretion pathway protein C FDP11_RS23845 ENOG4105VEJ Heat shock protein FDP11_RS23850 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FDP11_RS23855 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FDP11_RS23865 ENOG4105SUU thioesterase domain FDP11_RS23870 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FDP11_RS23875 ENOG4107S2Z UPF0761 membrane protein FDP11_RS23890 ENOG4105CI3 gtp-binding protein typa FDP11_RS23895 ENOG4105C5F glutamine synthetase FDP11_RS23905 ENOG4105CUX Signal transduction histidine kinase FDP11_RS23910 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_RS23915 ENOG4105BZU Histidine kinase FDP11_RS23920 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FDP11_RS23925 ENOG4105D4P Coproporphyrinogen iii oxidase FDP11_RS23930 ENOG4105XCT Protein of unknown function (DUF2489) FDP11_RS23935 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) FDP11_RS23950 ENOG4106RE7 Cytochrome FDP11_RS23955 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FDP11_RS23960 ENOG4105C2M dna polymerase I FDP11_RS23970 ENOG4105D52 delta-aminolevulinic acid dehydratase FDP11_RS23975 ENOG4105F8V Hydrolase, tatD family FDP11_RS23980 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FDP11_RS23990 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FDP11_RS23995 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FDP11_RS24000 ENOG4105JC1 sterol-binding domain protein FDP11_RS24005 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FDP11_RS24010 ENOG4105CGY Dna recombination protein FDP11_RS24020 ENOG4105BZU Histidine kinase FDP11_RS24025 ENOG4105DSF transport protein FDP11_RS24080 ENOG4108JUA Transcriptional regulator FDP11_RS24085 ENOG4105CBX hi0933 family FDP11_RS24090 ENOG4108V6B universal stress protein B FDP11_RS24095 ENOG41090A1 ferritin FDP11_RS24100 ENOG4108M6U Universal stress protein A FDP11_RS24105 ENOG4105EMK carboxylate amino acid amine transporter FDP11_RS24115 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FDP11_RS24120 ENOG4105BZU Histidine kinase FDP11_RS24125 ENOG4108VVK transcriptional Regulator, AsnC FDP11_RS24130 ENOG4105DGW oligopeptidase A FDP11_RS24135 ENOG4105D6S protein involved in catabolism of external DNA FDP11_RS24140 ENOG4105DC8 reductase FDP11_RS24145 ENOG4107RSM transcriptional regulator FDP11_RS24150 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FDP11_RS24155 ENOG4108UHU Aldolase FDP11_RS24160 ENOG4105C6Z Gluconate FDP11_RS24165 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FDP11_RS24170 ENOG4105C01 Dihydroxy-acid dehydratase FDP11_RS24180 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) FDP11_RS24185 ENOG41064T2 transcriptional regulator, lysR family FDP11_RS24190 ENOG4105DIQ Transcriptional regulator FDP11_RS24195 ENOG4105D9P serine threonine protein kinase FDP11_RS24225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDP11_RS24230 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FDP11_RS24235 ENOG4105DEF Extracellular solute-binding protein, family 5 FDP11_RS24240 ENOG4108JQ6 ABC transporter FDP11_RS24275 ENOG4105MPD Cytochrome FDP11_RS24280 ENOG4105C4R Atp-dependent dna helicase FDP11_RS24285 ENOG41067SE Tetr family transcriptional regulator FDP11_RS24290 ENOG410624X efflux transporter, rnd family, mfp subunit FDP11_RS24295 ENOG4105BZS acriflavin resistance protein FDP11_RS24300 ENOG4105W0Z cytoplasmic protein FDP11_RS24305 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FDP11_RS24310 ENOG4105EMY transcriptional regulator FDP11_RS24345 ENOG4108Z0R Transferase FDP11_RS24350 ENOG4105SG3 Protein of unknown function (DUF1488) FDP11_RS24355 ENOG4105E2X shikimate dehydrogenase FDP11_RS24360 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FDP11_RS24365 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FDP11_RS24370 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FDP11_RS24375 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FDP11_RS24380 ENOG4108WI1 Dna topoisomerase FDP11_RS24385 ENOG4108RPN Protein smg homolog FDP11_RS24390 ENOG4105C79 DNA protecting protein DprA FDP11_RS24405 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FDP11_RS24410 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FDP11_RS24415 ENOG4105C1A potassium transporter peripheral membrane FDP11_RS24420 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FDP11_RS24430 ENOG4108UT2 hemolysin iii FDP11_RS24435 ENOG4108N23 SpoOM-related protein FDP11_RS24445 ENOG4105PC1 Conserved Protein FDP11_RS24455 ENOG4105E27 serine threonine protein kinase FDP11_RS24460 ENOG4108Z33 Thiol disulfide Interchange Protein FDP11_RS24465 ENOG4106HNH Acyl-transferase FDP11_RS24475 ENOG4105C0P Mg chelatase subunit ChlI FDP11_RS24485 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FDP11_RS24490 ENOG4105CM2 brancheD-chain amino acid aminotransferase FDP11_RS24495 ENOG4105C01 Dihydroxy-acid dehydratase FDP11_RS24500 ENOG4105C7B Threonine dehydratase FDP11_RS24505 ENOG4105F52 Transcriptional regulator FDP11_RS24510 ENOG4105CZQ inner membrane transport protein YdhC FDP11_RS24520 ENOG4105EAD ABC transporter FDP11_RS24525 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FDP11_RS24530 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FDP11_RS24535 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FDP11_RS24540 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FDP11_RS24545 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FDP11_RS24550 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FDP11_RS24555 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FDP11_RS24560 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FDP11_RS24565 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) FDP11_RS24570 ENOG410684E atp synthase FDP11_RS24575 ENOG4105FA0 parb-like partition protein FDP11_RS24580 ENOG4107QJE Chromosome Partitioning Protein FDP11_RS24585 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FDP11_RS24590 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FDP11_RS24595 ENOG4105QTB Flavodoxin FDP11_RS24600 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FDP11_RS24605 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FDP11_RS24615 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FDP11_RS24630 ENOG4105E5Q amino acid AbC transporter FDP11_RS24635 ENOG4105EAB amino acid AbC transporter FDP11_RS24640 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FDP11_RS24645 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FDP11_RS24650 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FDP11_RS24655 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDP11_RS24665 ENOG4108ZNX Heat shock protein FDP11_RS24670 ENOG4105JKW Valine--pyruvate aminotransferase FDP11_RS24675 ENOG4107T9C Alpha amylase catalytic region FDP11_RS24680 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FDP11_RS24685 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FDP11_RS24700 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FDP11_RS24715 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FDP11_RS24720 ENOG4105CHU acetyl-coa acetyltransferase FDP11_RS24725 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FDP11_RS24730 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FDP11_RS24735 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FDP11_RS24740 ENOG4108RR8 protoporphyrinogen oxidase FDP11_RS24785 ENOG4105WMR Protein CrcB homolog FDP11_RS24790 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FDP11_RS24795 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FDP11_RS24800 ENOG4105D06 uba thif-type nad fad binding protein FDP11_RS24805 ENOG4105WHD thiamine biosynthesis protein ThiS FDP11_RS24810 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FDP11_RS24815 ENOG4105D41 biosynthesis protein thiH FDP11_RS24820 ENOG4105DC7 peptidase M24 FDP11_RS24820 ENOG4105DC7 peptidase M24 FDP11_RS24850 ENOG4105E18 UPF0276 protein FDP11_RS24860 ENOG4105C4R Atp-dependent dna helicase FDP11_RS24865 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FDP11_RS24870 ENOG4105CCF Lysine exporter protein (Lyse ygga) FDP11_RS24880 ENOG4105FR1 rard protein FDP11_RS24885 ENOG4105C9U ATP-dependent DNA helicase RecQ FDP11_RS24895 ENOG4105EX9 Membrane FDP11_RS24900 ENOG4105C9X ppx gppa phosphatase FDP11_RS24905 ENOG4105C1J atp-dependent rna helicase FDP11_RS24915 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FDP11_RS24925 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FDP11_RS24930 ENOG4108ZIT Ferredoxin, 2FE-2S FDP11_RS24935 ENOG4107QK7 reductase FDP11_RS24975 ENOG410601J HemY protein FDP11_RS24980 ENOG4105ECF c-methyltransferase FDP11_RS24985 ENOG41076E6 Uroporphyrinogen-III Synthase FDP11_RS24990 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FDP11_RS24995 ENOG4107T0K Adenylate cyclase FDP11_RS25000 ENOG4105XQ6 frataxin-like protein FDP11_RS25010 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FDP11_RS25015 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)