locus-tag	class	description
BSR23_RS00050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BSR23_RS00055	COG1739	Uncharacterized protein family UPF0029
BSR23_RS00060	COG1024	Enoyl-CoA hydratase
BSR23_RS00060	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSR23_RS00065	COG0183	Belongs to the thiolase family
BSR23_RS00070	COG0604	alcohol dehydrogenase
BSR23_RS00085	COG0425	Belongs to the sulfur carrier protein TusA family
BSR23_RS00095	COG2119	membrane
BSR23_RS00100	COG0752	glycyl-tRNA synthetase alpha subunit
BSR23_RS00105	COG0751	glycine-tRNA ligase activity
BSR23_RS00110	COG0366	Alpha amylase catalytic
BSR23_RS00115	COG3977	Valine--pyruvate aminotransferase
BSR23_RS00120	COG0071	Belongs to the small heat shock protein (HSP20) family
BSR23_RS00140	COG0187	DNA topoisomerase II activity
BSR23_RS00145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BSR23_RS00150	COG0592	DNA-directed DNA polymerase activity
BSR23_RS00155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BSR23_RS00180	COG1126	abc transporter atp-binding protein
BSR23_RS00190	COG0594	ribonuclease P activity
BSR23_RS00200	COG0706	membrane insertase activity
BSR23_RS00205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BSR23_RS00210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BSR23_RS00215	COG0445	tRNA wobble uridine modification
BSR23_RS00220	COG0357	Ribosomal RNA small subunit methyltransferase G
BSR23_RS00225	COG1192	Involved in chromosome partitioning
BSR23_RS00230	COG1475	DNA binding
BSR23_RS00235	COG3312	ion transport
BSR23_RS00240	COG0356	it plays a direct role in the translocation of protons across the membrane
BSR23_RS00255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BSR23_RS00260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BSR23_RS00265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BSR23_RS00270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BSR23_RS00275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BSR23_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BSR23_RS00285	COG0765	amino acid transport
BSR23_RS00290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR23_RS00295	COG2814	Major facilitator Superfamily
BSR23_RS00300	COG0583	DNA-binding transcription factor activity
BSR23_RS00310	COG0129	dihydroxy-acid dehydratase activity
BSR23_RS00315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BSR23_RS00320	COG3978	acetolactate synthase activity
BSR23_RS00410	COG0204	Acyl-transferase
BSR23_RS00415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BSR23_RS00420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSR23_RS00430	COG3084	Protein conserved in bacteria
BSR23_RS00440	COG4326	sporulation control protein
BSR23_RS00445	COG1272	protein, Hemolysin III
BSR23_RS00455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BSR23_RS00460	COG0569	domain protein
BSR23_RS00465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BSR23_RS00465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSR23_RS00470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BSR23_RS00475	COG0242	peptide deformylase activity
BSR23_RS00485	COG0758	DNA mediated transformation
BSR23_RS00490	COG2922	Belongs to the Smg family
BSR23_RS00495	COG0551	DNA topoisomerase type I activity
BSR23_RS00500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BSR23_RS00505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BSR23_RS00510	COG0009	L-threonylcarbamoyladenylate synthase
BSR23_RS00515	COG0408	coproporphyrinogen oxidase activity
BSR23_RS00520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BSR23_RS00530	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BSR23_RS00580	COG3335	DDE superfamily endonuclease
BSR23_RS00595	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BSR23_RS00600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BSR23_RS00605	COG0352	thiamine-phosphate diphosphorylase activity
BSR23_RS00610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSR23_RS00615	COG2104	thiamine diphosphate biosynthetic process
BSR23_RS00620	COG2022	thiamine diphosphate biosynthetic process
BSR23_RS00630	COG0006	proline dipeptidase activity
BSR23_RS00630	COG0006	proline dipeptidase activity
BSR23_RS00660	COG3220	belongs to the UPF0276 family
BSR23_RS00670	COG0210	DNA helicase
BSR23_RS00680	COG0405	Gamma-glutamyltransferase
BSR23_RS00685	COG1280	lysine exporter protein (LysE YggA)
BSR23_RS00695	COG2962	Rard protein
BSR23_RS00700	COG0514	ATP-dependent DNA helicase (RecQ)
BSR23_RS00715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BSR23_RS00720	COG0248	Ppx GppA phosphatase
BSR23_RS00725	COG0513	Belongs to the DEAD box helicase family
BSR23_RS00730	COG3118	belongs to the thioredoxin family
BSR23_RS00750	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BSR23_RS00755	COG0633	Ferredoxin
BSR23_RS00805	COG3071	HemY protein
BSR23_RS00810	COG2959	enzyme of heme biosynthesis
BSR23_RS00815	COG1587	Uroporphyrinogen-III synthase
BSR23_RS00820	COG0181	hydroxymethylbilane synthase activity
BSR23_RS00825	COG3072	Adenylate cyclase
BSR23_RS00830	COG1965	Belongs to the frataxin family
BSR23_RS00840	COG0019	diaminopimelate decarboxylase activity
BSR23_RS00845	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BSR23_RS00855	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BSR23_RS00860	COG1011	Hydrolase
BSR23_RS00865	COG3287	FIST C domain
BSR23_RS00865	COG2200	EAL domain
BSR23_RS00865	COG2199	diguanylate cyclase activity
BSR23_RS00870	COG3148	PFAM DTW domain containing protein
BSR23_RS00885	COG0561	phosphatase activity
BSR23_RS00895	COG2267	carboxylic ester hydrolase activity
BSR23_RS00900	COG1280	lysine exporter protein (LysE YggA)
BSR23_RS00905	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BSR23_RS00910	COG0640	Transcriptional regulator
BSR23_RS00915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BSR23_RS00970	COG2095	MarC family integral membrane protein
BSR23_RS00980	COG0742	ribosomal rna small subunit methyltransferase
BSR23_RS00985	COG0552	protein localization to endoplasmic reticulum
BSR23_RS00990	COG2884	Cell division ATP-binding protein ftsE
BSR23_RS00995	COG2177	Part of the ABC transporter FtsEX involved in
BSR23_RS01010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BSR23_RS01015	COG0705	Rhomboid family
BSR23_RS01020	COG1580	Controls the rotational direction of flagella during chemotaxis
BSR23_RS01025	COG3161	chorismate lyase activity
BSR23_RS01030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BSR23_RS01035	COG2937	Belongs to the GPAT DAPAT family
BSR23_RS01050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BSR23_RS01055	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BSR23_RS01060	COG0534	Mate efflux family protein
BSR23_RS01065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSR23_RS01080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSR23_RS01085	COG4206	TonB-dependent receptor
BSR23_RS01095	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BSR23_RS01130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSR23_RS01140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BSR23_RS01175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BSR23_RS01185	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BSR23_RS01190	COG0250	Participates in transcription elongation, termination and antitermination
BSR23_RS01195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BSR23_RS01200	COG0081	regulation of translation
BSR23_RS01205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BSR23_RS01210	COG0222	ribosome binding
BSR23_RS01215	COG0085	RNA polymerase activity
BSR23_RS01220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BSR23_RS01225	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BSR23_RS01230	COG2816	NAD+ diphosphatase activity
BSR23_RS01245	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BSR23_RS01250	COG1573	uracil-dna glycosylase
BSR23_RS01265	COG1253	flavin adenine dinucleotide binding
BSR23_RS01280	COG0151	Belongs to the GarS family
BSR23_RS01290	COG0138	bifunctional purine biosynthesis protein purh
BSR23_RS01300	COG0789	Transcriptional regulator
BSR23_RS01305	COG3710	Transcriptional regulator
BSR23_RS01315	COG0531	amino acid
BSR23_RS01320	COG1982	Orn Lys Arg decarboxylase major
BSR23_RS01415	COG3706	GGDEF domain
BSR23_RS01420	COG0488	(ABC) transporter
BSR23_RS01430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BSR23_RS01435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BSR23_RS01440	COG2264	protein methyltransferase activity
BSR23_RS01450	COG0439	Biotin carboxylase
BSR23_RS01455	COG0511	ligase activity, forming carbon-carbon bonds
BSR23_RS01460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BSR23_RS01465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSR23_RS01480	COG2814	Major facilitator Superfamily
BSR23_RS01485	COG2198	Histidine kinase
BSR23_RS01485	COG2205	protein histidine kinase activity
BSR23_RS01485	COG0784	Response regulator, receiver
BSR23_RS01510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSR23_RS01520	COG3263	regulation of cellular component size
BSR23_RS01530	COG4232	protein-disulfide reductase activity
BSR23_RS01535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BSR23_RS01540	COG1027	Aspartate ammonia-lyase
BSR23_RS01545	COG3030	protein affecting phage T7 exclusion by the F plasmid
BSR23_RS01550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BSR23_RS01560	COG2205	protein histidine kinase activity
BSR23_RS01565	COG0745	RESPONSE REGULATOR receiver
BSR23_RS01570	COG3678	ATP-independent chaperone mediated protein folding
BSR23_RS01580	COG0205	6-phosphofructokinase activity
BSR23_RS01585	COG0534	Mate efflux family protein
BSR23_RS01595	COG0459	protein refolding
BSR23_RS01610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BSR23_RS01620	COG1509	lysine 2,3-aminomutase activity
BSR23_RS01625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BSR23_RS01635	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BSR23_RS01640	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BSR23_RS01645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BSR23_RS01650	COG1053	succinate dehydrogenase
BSR23_RS01660	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BSR23_RS01680	COG4942	peptidase
BSR23_RS01685	COG1045	serine acetyltransferase
BSR23_RS01690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BSR23_RS01695	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BSR23_RS01700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BSR23_RS01705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BSR23_RS01720	COG0471	metal ion transport
BSR23_RS01725	COG0688	phosphatidylethanolamine metabolic process
BSR23_RS01730	COG1162	GTPase activity
BSR23_RS01735	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BSR23_RS01805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BSR23_RS01810	COG0802	atpase or kinase
BSR23_RS01815	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSR23_RS01820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BSR23_RS01825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BSR23_RS01835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BSR23_RS01840	COG0330	HflC and HflK could
BSR23_RS01845	COG0330	HflC and HflK could
BSR23_RS01850	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BSR23_RS01855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BSR23_RS01865	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BSR23_RS01870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BSR23_RS01870	COG1017	nitric oxide dioxygenase activity
BSR23_RS01875	COG1959	2 iron, 2 sulfur cluster binding
BSR23_RS01880	COG0557	exoribonuclease II activity
BSR23_RS01885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSR23_RS01890	COG0546	phosphoglycolate phosphatase activity
BSR23_RS01895	COG0180	Tryptophanyl-tRNA synthetase
BSR23_RS01925	COG0512	Glutamine amidotransferase of anthranilate synthase
BSR23_RS01930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BSR23_RS01940	COG1012	belongs to the aldehyde dehydrogenase family
BSR23_RS01950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BSR23_RS01955	COG3954	Phosphoribulokinase
BSR23_RS01960	COG3089	Belongs to the UPF0270 family
BSR23_RS01965	COG0429	hydrolase of the alpha beta-hydrolase fold
BSR23_RS01975	COG0488	(ABC) transporter
BSR23_RS01985	COG2249	NAD(P)H dehydrogenase (quinone) activity
BSR23_RS02000	COG1047	Peptidyl-prolyl cis-trans
BSR23_RS02010	COG1446	asparaginase
BSR23_RS02015	COG2900	Belongs to the SlyX family
BSR23_RS02025	COG0545	Peptidyl-prolyl cis-trans isomerase
BSR23_RS02030	COG2964	Protein conserved in bacteria
BSR23_RS02035	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BSR23_RS02040	COG2923	Belongs to the DsrF TusC family
BSR23_RS02055	COG0049	tRNA binding
BSR23_RS02060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BSR23_RS02065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BSR23_RS02070	COG2906	2 iron, 2 sulfur cluster binding
BSR23_RS02080	COG0281	malic enzyme
BSR23_RS02090	COG0626	cystathionine gamma-synthase activity
BSR23_RS02095	COG0527	aspartate kinase activity
BSR23_RS02095	COG0460	homoserine dehydrogenase
BSR23_RS02100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BSR23_RS02110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BSR23_RS02115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSR23_RS02120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BSR23_RS02125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BSR23_RS02130	COG0137	argininosuccinate synthase activity
BSR23_RS02135	COG0165	Argininosuccinate lyase
BSR23_RS02135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BSR23_RS02150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BSR23_RS02150	COG0678	peroxiredoxin activity
BSR23_RS02160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BSR23_RS02190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BSR23_RS02195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BSR23_RS02205	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BSR23_RS02210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BSR23_RS02215	COG0360	Binds together with S18 to 16S ribosomal RNA
BSR23_RS02220	COG2965	DNA replication, synthesis of RNA primer
BSR23_RS02230	COG0359	binds to the 23S rRNA
BSR23_RS02245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BSR23_RS02255	COG0432	Pfam Uncharacterised protein family UPF0047
BSR23_RS02260	COG0166	Belongs to the GPI family
BSR23_RS02270	COG0735	belongs to the Fur family
BSR23_RS02375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BSR23_RS02395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BSR23_RS02420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BSR23_RS02425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BSR23_RS02430	COG0175	sulfate reduction
BSR23_RS02495	COG3335	DDE superfamily endonuclease
BSR23_RS02510	COG0646	methionine synthase
BSR23_RS02510	COG1410	methionine synthase
BSR23_RS02515	COG0527	aspartate kinase activity
BSR23_RS02525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BSR23_RS02535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BSR23_RS02550	COG0629	single-stranded DNA binding
BSR23_RS02555	COG2200	EAL domain
BSR23_RS02555	COG2199	diguanylate cyclase activity
BSR23_RS02580	COG3409	Peptidoglycan-binding domain 1 protein
BSR23_RS02580	COG3267	Type II secretory pathway component ExeA
BSR23_RS02590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BSR23_RS02595	COG1459	type II secretion system
BSR23_RS02605	COG2165	general secretion pathway protein
BSR23_RS02640	COG1077	Cell shape determining protein MreB Mrl
BSR23_RS02645	COG1792	Involved in formation and maintenance of cell shape
BSR23_RS02650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BSR23_RS02655	COG0424	maF-like protein
BSR23_RS02665	COG3164	Protein of unknown function
BSR23_RS02670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSR23_RS02675	COG0312	modulator of DNA gyrase
BSR23_RS02680	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BSR23_RS02685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BSR23_RS02700	COG0564	pseudouridine synthase activity
BSR23_RS02705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BSR23_RS02710	COG3028	Belongs to the UPF0307 family
BSR23_RS02715	COG0312	modulator of DNA gyrase
BSR23_RS02720	COG2239	Acts as a magnesium transporter
BSR23_RS02725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR23_RS02730	COG1660	Displays ATPase and GTPase activities
BSR23_RS02735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR23_RS02740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BSR23_RS02750	COG1137	ATPase activity
BSR23_RS02755	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BSR23_RS02765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BSR23_RS02765	COG0517	IMP dehydrogenase activity
BSR23_RS02775	COG1127	ABC transporter
BSR23_RS02780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BSR23_RS02785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BSR23_RS02790	COG2854	intermembrane phospholipid transfer
BSR23_RS02800	COG5007	Belongs to the BolA IbaG family
BSR23_RS02805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BSR23_RS02810	COG0204	Acyl-transferase
BSR23_RS02815	COG0251	oxidation-reduction process
BSR23_RS02820	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BSR23_RS02825	COG0540	Belongs to the ATCase OTCase family
BSR23_RS02835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BSR23_RS02840	COG2235	arginine
BSR23_RS02870	COG0525	valine-tRNA ligase activity
BSR23_RS02875	COG2927	DNA polymerase III (CHI subunit)
BSR23_RS02880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BSR23_RS02885	COG0795	lipopolysaccharide-transporting ATPase activity
BSR23_RS02890	COG0795	lipopolysaccharide-transporting ATPase activity
BSR23_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
BSR23_RS02915	COG0726	polysaccharide deacetylase
BSR23_RS02920	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BSR23_RS02925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BSR23_RS02930	COG1447	Phosphotransferase system cellobiose-specific component IIA
BSR23_RS02935	COG1486	melibiose metabolic process
BSR23_RS02940	COG3394	polysaccharide catabolic process
BSR23_RS02950	COG3437	response regulator, receiver
BSR23_RS03005	COG1012	belongs to the aldehyde dehydrogenase family
BSR23_RS03075	COG0741	lytic transglycosylase activity
BSR23_RS03080	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BSR23_RS03090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BSR23_RS03100	COG2066	Belongs to the glutaminase family
BSR23_RS03105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BSR23_RS03110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BSR23_RS03120	COG1872	DUF167
BSR23_RS03125	COG0762	integral membrane protein
BSR23_RS03130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BSR23_RS03135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BSR23_RS03150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BSR23_RS03155	COG1678	Uncharacterized ACR, COG1678
BSR23_RS03160	COG0189	ligase activity
BSR23_RS03165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BSR23_RS03170	COG2356	endonuclease I
BSR23_RS03175	COG3091	SprT-like family
BSR23_RS03185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BSR23_RS03195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BSR23_RS03200	COG0583	DNA-binding transcription factor activity
BSR23_RS03205	COG4771	TonB-dependent receptor
BSR23_RS03210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BSR23_RS03215	COG0126	phosphoglycerate kinase activity
BSR23_RS03220	COG0191	fructose-bisphosphate aldolase activity
BSR23_RS03225	COG0668	transmembrane transport
BSR23_RS03230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BSR23_RS03240	COG0583	DNA-binding transcription factor activity
BSR23_RS03250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BSR23_RS03255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BSR23_RS03260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BSR23_RS03270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BSR23_RS03280	COG3079	Belongs to the UPF0149 family
BSR23_RS03285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BSR23_RS03290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BSR23_RS03305	COG0354	folic acid binding
BSR23_RS03310	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BSR23_RS03320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BSR23_RS03330	COG1595	DNA-templated transcription, initiation
BSR23_RS03335	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BSR23_RS03345	COG3086	response to oxidative stress
BSR23_RS03350	COG0481	GTPase activity
BSR23_RS03360	COG0571	ribonuclease III activity
BSR23_RS03365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BSR23_RS03370	COG1381	Involved in DNA repair and RecF pathway recombination
BSR23_RS03375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BSR23_RS03380	COG0736	holo-[acyl-carrier-protein] synthase activity
BSR23_RS03395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSR23_RS03405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BSR23_RS03410	COG3956	TIGRFAM MazG family protein
BSR23_RS03415	COG0504	CTP synthase activity
BSR23_RS03420	COG0148	phosphopyruvate hydratase activity
BSR23_RS03425	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BSR23_RS03430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BSR23_RS03435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BSR23_RS03440	COG0585	pseudouridine synthase activity
BSR23_RS03445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BSR23_RS03450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BSR23_RS03465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BSR23_RS03470	COG1546	Belongs to the CinA family
BSR23_RS03475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BSR23_RS03480	COG2137	regulation of response to DNA damage stimulus
BSR23_RS03485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BSR23_RS03490	COG0527	aspartate kinase activity
BSR23_RS03555	COG3630	sodium ion export across plasma membrane
BSR23_RS03560	COG0511	ligase activity, forming carbon-carbon bonds
BSR23_RS03560	COG5016	pyruvate
BSR23_RS03565	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BSR23_RS03575	COG1238	metal cluster binding
BSR23_RS03580	COG0612	Peptidase, M16
BSR23_RS03585	COG2918	glutathione biosynthetic process
BSR23_RS03595	COG1854	S-ribosylhomocysteine lyase activity
BSR23_RS03600	COG4536	flavin adenine dinucleotide binding
BSR23_RS03605	COG4137	Cytochrome C assembly protein
BSR23_RS03610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BSR23_RS03615	COG0228	four-way junction DNA binding
BSR23_RS03620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BSR23_RS03625	COG0336	Belongs to the RNA methyltransferase TrmD family
BSR23_RS03630	COG0335	large ribosomal subunit rRNA binding
BSR23_RS03635	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BSR23_RS03640	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BSR23_RS03645	COG0237	dephospho-CoA kinase activity
BSR23_RS03655	COG1459	type II secretion system
BSR23_RS03660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BSR23_RS03670	COG0157	Belongs to the NadC ModD family
BSR23_RS03680	COG2186	Transcriptional regulator
BSR23_RS03685	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BSR23_RS03690	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSR23_RS03695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSR23_RS03710	COG0288	reversible hydration of carbon dioxide
BSR23_RS03725	COG1131	(ABC) transporter
BSR23_RS03730	COG0842	Transport permease protein
BSR23_RS03740	COG1560	Kdo2-lipid A biosynthetic process
BSR23_RS03750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BSR23_RS03755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BSR23_RS03760	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BSR23_RS03775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BSR23_RS03790	COG1489	DNA binding
BSR23_RS03795	COG1643	Atp-dependent helicase
BSR23_RS03800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSR23_RS03805	COG1752	Esterase of the alpha-beta hydrolase superfamily
BSR23_RS03810	COG1049	propionate catabolic process, 2-methylcitrate cycle
BSR23_RS03815	COG3112	Uncharacterised protein family (UPF0231)
BSR23_RS03825	COG0004	ammonium transporteR
BSR23_RS03830	COG1840	ABC-type Fe3 transport system, periplasmic component
BSR23_RS03840	COG3842	ATPase activity
BSR23_RS03845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BSR23_RS03860	COG2971	BadF BadG BcrA BcrD
BSR23_RS03870	COG4608	Belongs to the ABC transporter superfamily
BSR23_RS03875	COG0444	Belongs to the ABC transporter superfamily
BSR23_RS03880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSR23_RS03890	COG0747	negative chemotaxis
BSR23_RS03895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR23_RS03895	COG2205	protein histidine kinase activity
BSR23_RS03895	COG2198	Histidine kinase
BSR23_RS03895	COG0784	Response regulator, receiver
BSR23_RS03905	COG2813	Specifically methylates the guanine in position
BSR23_RS03910	COG0628	permease
BSR23_RS03915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BSR23_RS03920	COG0316	Belongs to the HesB IscA family
BSR23_RS03930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSR23_RS03935	COG0739	heme binding
BSR23_RS03940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BSR23_RS03950	COG2027	D-alanyl-D-alanine carboxypeptidase
BSR23_RS03955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BSR23_RS03960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BSR23_RS03965	COG1534	Rna-binding protein
BSR23_RS03970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BSR23_RS03975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BSR23_RS03980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BSR23_RS03985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BSR23_RS03995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BSR23_RS04010	COG0779	Required for maturation of 30S ribosomal subunits
BSR23_RS04015	COG0195	Participates in both transcription termination and antitermination
BSR23_RS04020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BSR23_RS04025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BSR23_RS04030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BSR23_RS04035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BSR23_RS04040	COG1185	polyribonucleotide nucleotidyltransferase activity
BSR23_RS04055	COG0534	Mate efflux family protein
BSR23_RS04060	COG0826	peptidase U32
BSR23_RS04065	COG0826	peptidase U32
BSR23_RS04075	COG3154	lipid carrier protein
BSR23_RS04080	COG3153	acetyltransferase
BSR23_RS04100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BSR23_RS04140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BSR23_RS04165	COG0210	DNA helicase
BSR23_RS04245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BSR23_RS04310	COG0640	Transcriptional regulator
BSR23_RS04325	COG0786	glutamate:sodium symporter activity
BSR23_RS04330	COG3039	Transposase
BSR23_RS04365	COG2356	endonuclease I
BSR23_RS04380	COG0629	single-stranded DNA binding
BSR23_RS04395	COG0714	Associated with various cellular activities
BSR23_RS04420	COG2003	Belongs to the UPF0758 family
BSR23_RS04500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BSR23_RS04510	COG0084	hydrolase, TatD family'
BSR23_RS04515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BSR23_RS04520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BSR23_RS04525	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BSR23_RS04530	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BSR23_RS04535	COG0813	purine-nucleoside phosphorylase activity
BSR23_RS04545	COG0560	Phosphoserine phosphatase
BSR23_RS04555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BSR23_RS04560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BSR23_RS04565	COG0583	DNA-binding transcription factor activity
BSR23_RS04575	COG1022	Amp-dependent synthetase and ligase
BSR23_RS04580	COG2169	Transcriptional regulator
BSR23_RS04605	COG4964	Belongs to the GSP D family
BSR23_RS04665	COG0583	DNA-binding transcription factor activity
BSR23_RS04670	COG0531	amino acid
BSR23_RS04675	COG2731	YhcH YjgK YiaL family protein
BSR23_RS04680	COG3250	beta-galactosidase activity
BSR23_RS04685	COG1609	Transcriptional regulator
BSR23_RS04695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BSR23_RS04705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BSR23_RS04710	COG2017	converts alpha-aldose to the beta-anomer
BSR23_RS04725	COG2211	Major facilitator Superfamily
BSR23_RS04730	COG1609	Transcriptional regulator
BSR23_RS04735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSR23_RS04755	COG0598	Magnesium transport protein CorA
BSR23_RS04760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BSR23_RS04765	COG1349	DNA-binding transcription factor activity
BSR23_RS04770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BSR23_RS04775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BSR23_RS04790	COG2271	Major facilitator Superfamily
BSR23_RS04795	COG0584	glycerophosphoryl diester phosphodiesterase
BSR23_RS04800	COG2171	N-acyltransferase activity
BSR23_RS04805	COG3141	response to X-ray
BSR23_RS04825	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BSR23_RS04835	COG1074	ATP-dependent DNA helicase activity
BSR23_RS04840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BSR23_RS04850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BSR23_RS04850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BSR23_RS04865	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BSR23_RS04870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BSR23_RS04875	COG2166	iron-sulfur cluster assembly
BSR23_RS04880	COG3706	GGDEF domain
BSR23_RS04885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BSR23_RS04890	COG0693	protein deglycase activity
BSR23_RS04895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BSR23_RS04925	COG1595	DNA-templated transcription, initiation
BSR23_RS04945	COG3056	Lipoprotein
BSR23_RS04950	COG2813	Specifically methylates the guanine in position
BSR23_RS04955	COG0271	Belongs to the BolA IbaG family
BSR23_RS04960	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BSR23_RS04965	COG1805	sodium ion transport
BSR23_RS04970	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BSR23_RS04975	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BSR23_RS04980	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BSR23_RS04985	COG2871	sodium ion transport
BSR23_RS04990	COG1477	protein flavinylation
BSR23_RS05005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSR23_RS05010	COG0514	ATP-dependent DNA helicase (RecQ)
BSR23_RS05015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BSR23_RS05030	COG0733	neurotransmitter:sodium symporter activity
BSR23_RS05050	COG0442	prolyl-tRNA aminoacylation
BSR23_RS05055	COG1720	tRNA m6t6A37 methyltransferase activity
BSR23_RS05060	COG0254	rRNA binding
BSR23_RS05075	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BSR23_RS05080	COG1671	Belongs to the UPF0178 family
BSR23_RS05105	COG3098	single-species biofilm formation
BSR23_RS05110	COG0564	pseudouridine synthase activity
BSR23_RS05120	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BSR23_RS05125	COG0024	Methionine aminopeptidase
BSR23_RS05130	COG0052	Belongs to the universal ribosomal protein uS2 family
BSR23_RS05135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BSR23_RS05140	COG0528	UMP kinase activity
BSR23_RS05145	COG0233	cytoplasmic translational termination
BSR23_RS05150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BSR23_RS05155	COG0575	Belongs to the CDS family
BSR23_RS05160	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BSR23_RS05165	COG0750	zinc metalloprotease
BSR23_RS05175	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BSR23_RS05180	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BSR23_RS05185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BSR23_RS05190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BSR23_RS05195	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BSR23_RS05200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BSR23_RS05205	COG0587	DNA-directed DNA polymerase activity
BSR23_RS05210	COG0825	malonyl-CoA metabolic process
BSR23_RS05215	COG0037	tRNA processing
BSR23_RS05225	COG0347	Belongs to the P(II) protein family
BSR23_RS05230	COG3021	interspecies interaction between organisms
BSR23_RS05240	COG1388	LysM domain
BSR23_RS05240	COG0741	lytic transglycosylase activity
BSR23_RS05245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSR23_RS05250	COG2226	methyltransferase
BSR23_RS05255	COG0328	RNA-DNA hybrid ribonuclease activity
BSR23_RS05260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BSR23_RS05280	COG0456	acetyltransferase
BSR23_RS05290	COG1960	acyl-CoA dehydrogenase activity
BSR23_RS05295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BSR23_RS05300	COG0121	glutamine amidotransferase
BSR23_RS05305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BSR23_RS05310	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BSR23_RS05315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BSR23_RS05320	COG2233	PERMEase
BSR23_RS05340	COG1393	Belongs to the ArsC family
BSR23_RS05345	COG4783	chaperone-mediated protein folding
BSR23_RS05360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BSR23_RS05365	COG2716	regulation of RNA biosynthetic process
BSR23_RS05370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BSR23_RS05375	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BSR23_RS05390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSR23_RS05395	COG1393	Belongs to the ArsC family
BSR23_RS05425	COG2837	iron assimilation
BSR23_RS05430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR23_RS05440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR23_RS05445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR23_RS05450	COG1334	flagellar protein FlaG
BSR23_RS05455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BSR23_RS05465	COG1516	flagellar protein fliS
BSR23_RS05485	COG1677	Flagellar hook-basal body complex protein FliE
BSR23_RS05495	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BSR23_RS05545	COG1987	bacterial-type flagellum assembly
BSR23_RS05550	COG1684	flagellar biosynthetic protein fliR
BSR23_RS05585	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BSR23_RS05590	COG0643	Histidine kinase
BSR23_RS05590	COG2198	Histidine kinase
BSR23_RS05590	COG0784	Response regulator, receiver
BSR23_RS05595	COG2201	protein-glutamate methylesterase activity
BSR23_RS05600	COG1192	Involved in chromosome partitioning
BSR23_RS05610	COG0835	chemotaxis
BSR23_RS05620	COG4133	protoheme IX ABC transporter activity
BSR23_RS05625	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BSR23_RS05630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BSR23_RS05635	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BSR23_RS05640	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BSR23_RS05645	COG1138	Cytochrome C-type biogenesis protein
BSR23_RS05650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSR23_RS05665	COG2853	Lipoprotein
BSR23_RS05670	COG2067	long-chain fatty acid transport protein
BSR23_RS05675	COG2067	long-chain fatty acid transport protein
BSR23_RS05695	COG0183	Belongs to the thiolase family
BSR23_RS05700	COG1024	Enoyl-CoA hydratase
BSR23_RS05700	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSR23_RS05715	COG2062	phosphohistidine phosphatase, SixA
BSR23_RS05720	COG2840	Smr protein MutS2
BSR23_RS05725	COG2890	protein-(glutamine-N5) methyltransferase activity
BSR23_RS05730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BSR23_RS05735	COG2860	membrane
BSR23_RS05745	COG3101	peptidyl-lysine hydroxylation
BSR23_RS05760	COG0431	NADPH-dependent FMN reductase
BSR23_RS05765	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BSR23_RS05765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSR23_RS05770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BSR23_RS05780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BSR23_RS05785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BSR23_RS05795	COG0101	tRNA pseudouridine synthase activity
BSR23_RS05800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BSR23_RS05805	COG0285	dihydrofolate synthase activity
BSR23_RS05810	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BSR23_RS05815	COG1286	toxin biosynthetic process
BSR23_RS05820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BSR23_RS05825	COG0583	DNA-binding transcription factor activity
BSR23_RS05830	COG0745	RESPONSE REGULATOR receiver
BSR23_RS05840	COG2832	Protein of unknown function (DUF454)
BSR23_RS05845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSR23_RS05855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BSR23_RS05860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BSR23_RS05865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BSR23_RS05870	COG0814	amino acid
BSR23_RS05875	COG0251	oxidation-reduction process
BSR23_RS05880	COG3681	Belongs to the UPF0597 family
BSR23_RS05895	COG2261	transglycosylase associated protein
BSR23_RS05900	COG2983	Belongs to the UPF0260 family
BSR23_RS05905	COG0668	transmembrane transport
BSR23_RS05910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BSR23_RS05915	COG0346	lactoylglutathione lyase activity
BSR23_RS05925	COG1785	Belongs to the alkaline phosphatase family
BSR23_RS05945	COG2226	methyltransferase
BSR23_RS05960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BSR23_RS05965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSR23_RS05975	COG3139	Protein of unknown function (DUF1315)
BSR23_RS05980	COG0252	asparaginase activity
BSR23_RS05985	COG0616	signal peptide processing
BSR23_RS05990	COG0446	pyridine nucleotide-disulphide oxidoreductase
BSR23_RS05990	COG1902	pentaerythritol trinitrate reductase activity
BSR23_RS05995	COG0778	Nitroreductase
BSR23_RS06020	COG0123	including yeast histone deacetylase and acetoin utilization protein
BSR23_RS06030	COG3083	sulfuric ester hydrolase activity
BSR23_RS06035	COG3082	Protein of unknown function (DUF1414)
BSR23_RS06040	COG3081	Nucleoid-associated protein
BSR23_RS06055	COG1757	Na H antiporter
BSR23_RS06060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BSR23_RS06065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BSR23_RS06070	COG2095	MarC family integral membrane protein
BSR23_RS06075	COG1012	belongs to the aldehyde dehydrogenase family
BSR23_RS06075	COG1454	alcohol dehydrogenase
BSR23_RS06095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BSR23_RS06100	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BSR23_RS06110	COG4191	Histidine kinase
BSR23_RS06150	COG2056	Na+-H+ antiporter family
BSR23_RS06155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BSR23_RS06170	COG2885	chlorophyll binding
BSR23_RS06180	COG0346	lactoylglutathione lyase activity
BSR23_RS06185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BSR23_RS06190	COG4660	Part of a membrane complex involved in electron transport
BSR23_RS06195	COG4659	FMN binding
BSR23_RS06200	COG4658	electron transport chain
BSR23_RS06205	COG4656	Part of a membrane complex involved in electron transport
BSR23_RS06210	COG2878	Part of a membrane complex involved in electron transport
BSR23_RS06215	COG4657	Part of a membrane complex involved in electron transport
BSR23_RS06230	COG0556	nucleotide-excision repair
BSR23_RS06235	COG2204	response regulator
BSR23_RS06240	COG2198	Histidine kinase
BSR23_RS06245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BSR23_RS06250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BSR23_RS06255	COG0521	Mo-molybdopterin cofactor biosynthetic process
BSR23_RS06260	COG0315	cyclic pyranopterin monophosphate synthase activity
BSR23_RS06265	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BSR23_RS06270	COG0314	molybdopterin synthase activity
BSR23_RS06280	COG0601	transmembrane transport
BSR23_RS06285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSR23_RS06290	COG0444	Belongs to the ABC transporter superfamily
BSR23_RS06300	COG0435	Glutathione S-transferase
BSR23_RS06310	COG3174	membrane
BSR23_RS06315	COG0857	belongs to the CobB CobQ family
BSR23_RS06315	COG0280	phosphate acetyltransferase
BSR23_RS06320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BSR23_RS06325	COG3092	negative regulation of chromosome organization
BSR23_RS06335	COG4120	Belongs to the binding-protein-dependent transport system permease family
BSR23_RS06340	COG1122	ATPase activity
BSR23_RS06345	COG0366	Alpha amylase catalytic
BSR23_RS06355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BSR23_RS06360	COG0653	protein targeting
BSR23_RS06365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BSR23_RS06370	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BSR23_RS06375	COG2186	Transcriptional regulator
BSR23_RS06385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSR23_RS06385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSR23_RS06390	COG0489	protein tyrosine kinase activity
BSR23_RS06395	COG0572	uridine kinase
BSR23_RS06405	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BSR23_RS06410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BSR23_RS06415	COG0659	secondary active sulfate transmembrane transporter activity
BSR23_RS06425	COG1530	ribonuclease E activity
BSR23_RS06440	COG0564	pseudouridine synthase activity
BSR23_RS06445	COG0424	maF-like protein
BSR23_RS06450	COG1399	metal-binding, possibly nucleic acid-binding protein
BSR23_RS06460	COG0416	fatty acid biosynthetic process
BSR23_RS06465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BSR23_RS06470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BSR23_RS06495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BSR23_RS06500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BSR23_RS06510	COG0084	hydrolase, TatD family'
BSR23_RS06515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR23_RS06515	COG1263	PTS System
BSR23_RS06535	COG0733	neurotransmitter:sodium symporter activity
BSR23_RS06550	COG4667	esterase of the alpha-beta hydrolase superfamily
BSR23_RS06555	COG0469	pyruvate kinase activity
BSR23_RS06560	COG1940	carbohydrate kinase activity
BSR23_RS06565	COG0784	Response regulator, receiver
BSR23_RS06565	COG0835	chemotaxis
BSR23_RS06570	COG0587	DNA-directed DNA polymerase activity
BSR23_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
BSR23_RS06590	COG0616	signal peptide processing
BSR23_RS06595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BSR23_RS06600	COG0539	negative regulation of cytoplasmic translation
BSR23_RS06610	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BSR23_RS06615	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BSR23_RS06620	COG0284	orotidine-5'-phosphate decarboxylase activity
BSR23_RS06625	COG4166	transmembrane transport
BSR23_RS06650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BSR23_RS06660	COG3008	intermembrane lipid transfer
BSR23_RS06660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BSR23_RS06665	COG2995	paraquat-inducible protein a
BSR23_RS06670	COG3258	Cytochrome c
BSR23_RS06675	COG2863	cytochrome
BSR23_RS06715	COG4232	protein-disulfide reductase activity
BSR23_RS06720	COG3118	belongs to the thioredoxin family
BSR23_RS06750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR23_RS06760	COG1136	(ABC) transporter
BSR23_RS06760	COG0577	efflux transmembrane transporter activity
BSR23_RS06765	COG0577	efflux transmembrane transporter activity
BSR23_RS06765	COG1136	(ABC) transporter
BSR23_RS06770	COG1136	(ABC) transporter
BSR23_RS06770	COG0577	efflux transmembrane transporter activity
BSR23_RS06775	COG1335	isochorismatase
BSR23_RS06825	COG5002	protein histidine kinase activity
BSR23_RS06825	COG3850	Histidine kinase
BSR23_RS06830	COG0745	RESPONSE REGULATOR receiver
BSR23_RS06840	COG0840	transmembrane signaling receptor activity
BSR23_RS06845	COG1032	radical SAM domain protein
BSR23_RS06850	COG3706	GGDEF domain
BSR23_RS06850	COG4251	negative regulation of phosphorylation
BSR23_RS06850	COG5001	Diguanylate cyclase
BSR23_RS06850	COG2203	Gaf domain
BSR23_RS06865	COG0583	DNA-binding transcription factor activity
BSR23_RS06875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BSR23_RS06885	COG2350	Protein conserved in bacteria
BSR23_RS06895	COG2917	probably involved in intracellular septation
BSR23_RS06915	COG1301	dicarboxylic acid transport
BSR23_RS06925	COG0318	PFAM AMP-dependent synthetase and ligase
BSR23_RS06930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BSR23_RS06940	COG0159	tryptophan synthase activity
BSR23_RS06945	COG0133	tryptophan synthase activity
BSR23_RS06950	COG0135	phosphoribosylanthranilate isomerase activity
BSR23_RS06950	COG0134	indole-3-glycerol-phosphate synthase activity
BSR23_RS06955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BSR23_RS06960	COG0512	Glutamine amidotransferase of anthranilate synthase
BSR23_RS06965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BSR23_RS06975	COG0613	PHP domain protein
BSR23_RS06980	COG0009	L-threonylcarbamoyladenylate synthase
BSR23_RS06990	COG1187	pseudouridine synthase activity
BSR23_RS07000	COG3099	Belongs to the UPF0263 family
BSR23_RS07005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BSR23_RS07015	COG0417	DNA replication proofreading
BSR23_RS07020	COG2197	response regulator
BSR23_RS07025	COG0322	excinuclease ABC activity
BSR23_RS07065	COG0019	diaminopimelate decarboxylase activity
BSR23_RS07090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSR23_RS07095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSR23_RS07100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BSR23_RS07120	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BSR23_RS07130	COG0437	4 iron, 4 sulfur cluster binding
BSR23_RS07135	COG3301	Polysulphide reductase, NrfD
BSR23_RS07140	COG1138	Cytochrome C-type biogenesis protein
BSR23_RS07150	COG3088	subunit of a heme lyase
BSR23_RS07150	COG4235	cytochrome complex assembly
BSR23_RS07160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BSR23_RS07185	COG2989	Protein conserved in bacteria
BSR23_RS07190	COG3108	Peptidase M15
BSR23_RS07195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSR23_RS07210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BSR23_RS07235	COG1846	Transcriptional regulator
BSR23_RS07240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BSR23_RS07245	COG0840	transmembrane signaling receptor activity
BSR23_RS07265	COG1448	Aminotransferase
BSR23_RS07290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR23_RS07300	COG0017	Asparaginyl-tRNA synthetase
BSR23_RS07310	COG0720	synthase
BSR23_RS07320	COG2200	EAL domain
BSR23_RS07325	COG1760	l-serine dehydratase
BSR23_RS07330	COG0814	amino acid
BSR23_RS07335	COG0494	nUDIX hydrolase
BSR23_RS07345	COG2205	protein histidine kinase activity
BSR23_RS07345	COG0784	Response regulator, receiver
BSR23_RS07350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BSR23_RS07370	COG3106	COG3106 Predicted ATPase
BSR23_RS07375	COG3768	UPF0283 membrane protein
BSR23_RS07385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR23_RS07605	COG1280	lysine exporter protein (LysE YggA)
BSR23_RS07635	COG2026	Addiction module toxin, RelE StbE family
BSR23_RS07800	COG1942	4-Oxalocrotonate Tautomerase
BSR23_RS07905	COG2801	Transposase and inactivated derivatives
BSR23_RS08150	COG0346	lactoylglutathione lyase activity
BSR23_RS08245	COG0346	lactoylglutathione lyase activity
BSR23_RS08290	COG2801	Transposase and inactivated derivatives
BSR23_RS08385	COG2815	serine threonine protein kinase
BSR23_RS08385	COG0515	serine threonine protein kinase
BSR23_RS08585	COG1757	Na H antiporter
BSR23_RS08590	COG0174	glutamine synthetase
BSR23_RS08600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BSR23_RS08605	COG1917	Cupin 2, conserved barrel domain protein
BSR23_RS08605	COG1396	sequence-specific DNA binding
BSR23_RS08610	COG1012	belongs to the aldehyde dehydrogenase family
BSR23_RS08615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSR23_RS08625	COG2957	Belongs to the agmatine deiminase family
BSR23_RS08630	COG1012	belongs to the aldehyde dehydrogenase family
BSR23_RS08635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BSR23_RS08640	COG1227	inorganic diphosphatase activity
BSR23_RS08650	COG2771	luxR family
BSR23_RS08650	COG2200	EAL domain
BSR23_RS08665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BSR23_RS08680	COG1846	Transcriptional regulator
BSR23_RS08685	COG2315	Protein conserved in bacteria
BSR23_RS08705	COG0110	maltose O-acetyltransferase activity
BSR23_RS08735	COG3063	Type IV pilus biogenesis stability protein PilW
BSR23_RS08740	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BSR23_RS08755	COG0531	amino acid
BSR23_RS08765	COG1560	Kdo2-lipid A biosynthetic process
BSR23_RS08770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BSR23_RS08775	COG1280	lysine exporter protein (LysE YggA)
BSR23_RS08785	COG1115	amino acid carrier protein
BSR23_RS08810	COG1368	sulfuric ester hydrolase activity
BSR23_RS08815	COG0642	Histidine kinase
BSR23_RS08820	COG0745	RESPONSE REGULATOR receiver
BSR23_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
BSR23_RS08850	COG2113	Glycine betaine
BSR23_RS08855	COG4176	ABC-type proline glycine betaine transport system permease component
BSR23_RS08860	COG4175	Glycine betaine
BSR23_RS08875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BSR23_RS08880	COG0456	acetyltransferase
BSR23_RS08885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BSR23_RS08890	COG0662	Cupin 2, conserved barrel domain protein
BSR23_RS08895	COG0527	aspartate kinase activity
BSR23_RS08900	COG1858	cytochrome C peroxidase
BSR23_RS08915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR23_RS08930	COG3290	protein histidine kinase activity
BSR23_RS08935	COG4565	transcriptional regulatory protein
BSR23_RS08940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BSR23_RS08945	COG0363	glucosamine-6-phosphate deaminase activity
BSR23_RS08950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BSR23_RS08975	COG3284	Transcriptional regulator
BSR23_RS08980	COG1012	belongs to the aldehyde dehydrogenase family
BSR23_RS09050	COG4669	(LipO)protein
BSR23_RS09070	COG3177	Filamentation induced by cAMP protein fic
BSR23_RS09110	COG1073	alpha beta
BSR23_RS09115	COG1073	alpha beta
BSR23_RS09125	COG4792	protein secretion
BSR23_RS09130	COG4791	protein targeting
BSR23_RS09135	COG4794	Type iii secretion
BSR23_RS09140	COG4790	Type iii secretion
BSR23_RS09210	COG0457	Tetratricopeptide repeat
BSR23_RS09230	COG0730	response to heat
BSR23_RS09260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BSR23_RS09265	COG0372	Belongs to the citrate synthase family
BSR23_RS09275	COG2828	Protein conserved in bacteria
BSR23_RS09300	COG0561	phosphatase activity
BSR23_RS09305	COG0602	queuosine metabolic process
BSR23_RS09310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BSR23_RS09315	COG3706	GGDEF domain
BSR23_RS09355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BSR23_RS09360	COG0840	transmembrane signaling receptor activity
BSR23_RS09365	COG1254	Belongs to the acylphosphatase family
BSR23_RS09370	COG2920	part of a sulfur-relay system
BSR23_RS09380	COG0670	Belongs to the BI1 family
BSR23_RS09385	COG1126	abc transporter atp-binding protein
BSR23_RS09390	COG0765	amino acid transport
BSR23_RS09395	COG4597	amino acid ABC transporter
BSR23_RS09400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR23_RS09420	COG1666	GTP binding
BSR23_RS09425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BSR23_RS09445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BSR23_RS09445	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BSR23_RS09455	COG3008	intermembrane lipid transfer
BSR23_RS09460	COG2995	paraquat-inducible protein a
BSR23_RS09465	COG1132	(ABC) transporter
BSR23_RS09470	COG1956	GAF domain-containing protein
BSR23_RS09475	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
BSR23_RS09490	COG0308	aminopeptidase N
BSR23_RS09500	COG2902	Dehydrogenase
BSR23_RS09505	COG0167	dihydroorotate dehydrogenase activity
BSR23_RS09520	COG0116	Belongs to the methyltransferase superfamily
BSR23_RS09520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BSR23_RS09530	COG0488	(ABC) transporter
BSR23_RS09545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BSR23_RS09550	COG1067	ATP-dependent peptidase activity
BSR23_RS09555	COG3120	sequence-specific DNA binding
BSR23_RS09575	COG2801	Transposase and inactivated derivatives
BSR23_RS09630	COG2205	protein histidine kinase activity
BSR23_RS09630	COG0784	Response regulator, receiver
BSR23_RS09645	COG3278	Belongs to the heme-copper respiratory oxidase family
BSR23_RS09660	COG2010	Cytochrome c
BSR23_RS09670	COG2217	Heavy metal translocating P-type atpase
BSR23_RS09685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BSR23_RS09690	COG0589	response to stress
BSR23_RS09700	COG0037	tRNA processing
BSR23_RS09720	COG3842	ATPase activity
BSR23_RS09730	COG1177	transmembrane transport
BSR23_RS09740	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BSR23_RS09745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BSR23_RS09755	COG0004	ammonium transporteR
BSR23_RS09815	COG0437	4 iron, 4 sulfur cluster binding
BSR23_RS09820	COG3383	formate dehydrogenase (NAD+) activity
BSR23_RS09820	COG0243	molybdopterin cofactor binding
BSR23_RS09830	COG3381	protein complex oligomerization
BSR23_RS09855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BSR23_RS09860	COG0488	(ABC) transporter
BSR23_RS09870	COG4191	Histidine kinase
BSR23_RS09875	COG2204	response regulator
BSR23_RS09895	COG3842	ATPase activity
BSR23_RS09900	COG0746	molybdenum cofactor guanylyltransferase activity
BSR23_RS09915	COG1940	carbohydrate kinase activity
BSR23_RS09920	COG3148	PFAM DTW domain containing protein
BSR23_RS09955	COG3290	protein histidine kinase activity
BSR23_RS09955	COG0840	transmembrane signaling receptor activity
BSR23_RS09960	COG0791	NLP P60 protein
BSR23_RS09970	COG3706	GGDEF domain
BSR23_RS09975	COG2201	protein-glutamate methylesterase activity
BSR23_RS09980	COG3001	Fructosamine kinase
BSR23_RS09990	COG0307	riboflavin synthase, alpha
BSR23_RS09995	COG0534	Mate efflux family protein
BSR23_RS10005	COG1793	dna ligase
BSR23_RS10040	COG2204	response regulator
BSR23_RS10085	COG0438	transferase activity, transferring glycosyl groups
BSR23_RS10090	COG1215	transferase activity, transferring glycosyl groups
BSR23_RS10095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BSR23_RS10105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BSR23_RS10120	COG1643	Atp-dependent helicase
BSR23_RS10125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BSR23_RS10130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BSR23_RS10130	COG2221	Nitrite and sulphite reductase 4Fe-4S
BSR23_RS10140	COG3302	dmso reductase anchor subunit
BSR23_RS10145	COG0437	4 iron, 4 sulfur cluster binding
BSR23_RS10150	COG0243	molybdopterin cofactor binding
BSR23_RS10180	COG3706	GGDEF domain
BSR23_RS10190	COG0443	Heat shock 70 kDa protein
BSR23_RS10195	COG0443	Heat shock 70 kDa protein
BSR23_RS10225	COG1132	(ABC) transporter
BSR23_RS10230	COG1132	(ABC) transporter
BSR23_RS10255	COG0814	amino acid
BSR23_RS10270	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BSR23_RS10360	COG1522	sequence-specific DNA binding
BSR23_RS10395	COG0515	serine threonine protein kinase
BSR23_RS10420	COG3501	Rhs element vgr protein
BSR23_RS10475	COG0861	Integral membrane protein TerC family
BSR23_RS10485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BSR23_RS10490	COG1328	CTP reductase activity
BSR23_RS10495	COG1280	lysine exporter protein (LysE YggA)
BSR23_RS10505	COG3300	MHYT domain
BSR23_RS10505	COG5001	Diguanylate cyclase
BSR23_RS10515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR23_RS10515	COG4191	Histidine kinase
BSR23_RS10520	COG0471	metal ion transport
BSR23_RS10555	COG0583	DNA-binding transcription factor activity
BSR23_RS10560	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BSR23_RS10620	COG0625	glutathione transferase activity
BSR23_RS10630	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BSR23_RS10645	COG2195	Cleaves the N-terminal amino acid of tripeptides
BSR23_RS10655	COG0601	transmembrane transport
BSR23_RS10660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSR23_RS10665	COG0444	Belongs to the ABC transporter superfamily
BSR23_RS10685	COG3291	Pkd domain containing protein
BSR23_RS10700	COG1177	transmembrane transport
BSR23_RS10705	COG1176	ABC-type spermidine putrescine transport system, permease component I
BSR23_RS10710	COG3842	ATPase activity
BSR23_RS10715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BSR23_RS10720	COG2423	ornithine cyclodeaminase activity
BSR23_RS10740	COG3938	Belongs to the proline racemase family
BSR23_RS10770	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BSR23_RS10775	COG1451	nucleotide metabolic process
BSR23_RS10780	COG3475	LICD family
BSR23_RS10785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BSR23_RS10790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BSR23_RS10810	COG0583	DNA-binding transcription factor activity
BSR23_RS10830	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BSR23_RS10835	COG4139	cobalamin transport
BSR23_RS10840	COG2988	succinylglutamate desuccinylase activity
BSR23_RS10855	COG2062	phosphohistidine phosphatase, SixA
BSR23_RS10865	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BSR23_RS10870	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BSR23_RS10875	COG0702	epimerase
BSR23_RS10880	COG1823	symporter activity
BSR23_RS10885	COG2925	Exonuclease
BSR23_RS10890	COG1380	Effector of murein hydrolase LrgA
BSR23_RS10895	COG1346	cytolysis
BSR23_RS10900	COG0295	cytidine deaminase activity
BSR23_RS10905	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BSR23_RS10910	COG0500	methyltransferase
BSR23_RS10920	COG0776	regulation of translation
BSR23_RS10935	COG0072	phenylalanine-tRNA ligase activity
BSR23_RS10935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSR23_RS10940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BSR23_RS10945	COG3706	GGDEF domain
BSR23_RS10975	COG0393	Putative heavy-metal-binding
BSR23_RS10985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BSR23_RS10995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BSR23_RS11010	COG2188	Transcriptional regulator
BSR23_RS11015	COG1228	amidohydrolase
BSR23_RS11020	COG0010	Belongs to the arginase family
BSR23_RS11025	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BSR23_RS11030	COG2986	histidine ammonia-lyase
BSR23_RS11045	COG0277	FAD linked oxidase domain protein
BSR23_RS11045	COG0247	lactate metabolic process
BSR23_RS11080	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BSR23_RS11095	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
BSR23_RS11100	COG1643	Atp-dependent helicase
BSR23_RS11105	COG0281	malic enzyme
BSR23_RS11110	COG2949	membrane
BSR23_RS11115	COG0471	metal ion transport
BSR23_RS11140	COG0492	ferredoxin-NADP+ reductase activity
BSR23_RS11145	COG4988	ABC transporter
BSR23_RS11150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BSR23_RS11155	COG3048	D-serine ammonia-lyase activity
BSR23_RS11160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BSR23_RS11170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR23_RS11170	COG4191	Histidine kinase
BSR23_RS11185	COG3070	regulator of competence-specific genes
BSR23_RS11205	COG2431	L-lysine efflux transmembrane transporter activity
BSR23_RS11215	COG0076	glutamate decarboxylase activity
BSR23_RS11220	COG1737	Transcriptional regulator
BSR23_RS11235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BSR23_RS11240	COG3273	potassium ion transport
BSR23_RS11240	COG2985	domain, Protein
BSR23_RS11245	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BSR23_RS11260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BSR23_RS11275	COG4181	ATPase activity
BSR23_RS11280	COG0534	Mate efflux family protein
BSR23_RS11285	COG0702	epimerase
BSR23_RS11290	COG3005	denitrification pathway
BSR23_RS11320	COG2814	Major facilitator Superfamily
BSR23_RS11325	COG1187	pseudouridine synthase activity
BSR23_RS11330	COG1061	Type III restriction enzyme res subunit
BSR23_RS11350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BSR23_RS11380	COG3313	Fe-S protein
BSR23_RS11405	COG0493	'glutamate synthase
BSR23_RS11415	COG0398	Pfam SNARE associated Golgi protein
BSR23_RS11420	COG4134	Bacterial extracellular solute-binding protein
BSR23_RS11425	COG4135	transport system, permease component
BSR23_RS11430	COG4136	ATPase activity
BSR23_RS11435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BSR23_RS11450	COG3604	Transcriptional regulator
BSR23_RS11455	COG1151	hydroxylamine reductase activity
BSR23_RS11460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BSR23_RS11470	COG0564	pseudouridine synthase activity
BSR23_RS11480	COG0733	neurotransmitter:sodium symporter activity
BSR23_RS11490	COG0626	cystathionine gamma-synthase activity
BSR23_RS11495	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BSR23_RS11500	COG5380	lipid catabolic process
BSR23_RS11505	COG2818	Glycosylase
BSR23_RS11520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR23_RS11525	COG1983	PspC domain protein
BSR23_RS11535	COG1842	Phage shock protein A
BSR23_RS11540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BSR23_RS11555	COG4171	peptide transport system, permease
BSR23_RS11565	COG4172	Belongs to the ABC transporter superfamily
BSR23_RS11575	COG1227	inorganic diphosphatase activity
BSR23_RS11590	COG0243	molybdopterin cofactor binding
BSR23_RS11595	COG3005	denitrification pathway
BSR23_RS11600	COG4459	periplasmic nitrate reductase
BSR23_RS11605	COG0390	transport system, permease component
BSR23_RS11615	COG2116	formate transmembrane transporter activity
BSR23_RS11640	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BSR23_RS11645	COG1435	thymidine kinase activity
BSR23_RS11650	COG0215	cysteine-tRNA ligase activity
BSR23_RS11655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BSR23_RS11660	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BSR23_RS11665	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BSR23_RS11675	COG3012	SEC-C Motif Domain Protein
BSR23_RS11680	COG0140	phosphoribosyl-ATP diphosphatase activity
BSR23_RS11680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BSR23_RS11685	COG0107	imidazoleglycerol-phosphate synthase activity
BSR23_RS11690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BSR23_RS11695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BSR23_RS11700	COG0131	Imidazoleglycerol-phosphate dehydratase
BSR23_RS11700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BSR23_RS11705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BSR23_RS11710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BSR23_RS11715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BSR23_RS11730	COG1757	Na H antiporter
BSR23_RS11740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSR23_RS11750	COG0482	sulfurtransferase activity
BSR23_RS11755	COG2915	High frequency lysogenization protein hflD homolog
BSR23_RS11760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BSR23_RS11785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BSR23_RS11800	COG0300	oxidoreductase activity
BSR23_RS11810	COG0501	Belongs to the peptidase M48B family
BSR23_RS11820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BSR23_RS11830	COG0156	8-amino-7-oxononanoate synthase activity
BSR23_RS11835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BSR23_RS11840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BSR23_RS11845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BSR23_RS11860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BSR23_RS11865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BSR23_RS11870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BSR23_RS11875	COG1674	ftsk spoiiie
BSR23_RS11885	COG0686	Belongs to the AlaDH PNT family
BSR23_RS11895	COG0583	DNA-binding transcription factor activity
BSR23_RS11910	COG3568	Endonuclease Exonuclease Phosphatase
BSR23_RS11940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSR23_RS11945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR23_RS11960	COG0840	transmembrane signaling receptor activity
BSR23_RS11990	COG0784	Response regulator, receiver
BSR23_RS11990	COG5002	protein histidine kinase activity
BSR23_RS12000	COG0754	glutathionylspermidine amidase activity
BSR23_RS12010	COG3766	membrane
BSR23_RS12020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BSR23_RS12025	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BSR23_RS12030	COG2885	chlorophyll binding
BSR23_RS12035	COG0823	Involved in the tonB-independent uptake of proteins
BSR23_RS12050	COG0811	peptide transport
BSR23_RS12055	COG0824	Thioesterase
BSR23_RS12065	COG4890	Cyd operon protein YbgT
BSR23_RS12070	COG1294	oxidase, subunit
BSR23_RS12075	COG1271	oxidase subunit
BSR23_RS12080	COG2255	four-way junction helicase activity
BSR23_RS12085	COG0632	four-way junction helicase activity
BSR23_RS12090	COG0840	transmembrane signaling receptor activity
BSR23_RS12095	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BSR23_RS12100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BSR23_RS12105	COG1801	Protein of unknown function DUF72
BSR23_RS12115	COG0500	methyltransferase
BSR23_RS12125	COG0189	ligase activity
BSR23_RS12125	COG4067	protein conserved in archaea
BSR23_RS12145	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BSR23_RS12150	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BSR23_RS12155	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
BSR23_RS12160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BSR23_RS12165	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BSR23_RS12170	COG0745	RESPONSE REGULATOR receiver
BSR23_RS12175	COG3381	protein complex oligomerization
BSR23_RS12180	COG1609	Transcriptional regulator
BSR23_RS12185	COG3070	regulator of competence-specific genes
BSR23_RS12205	COG0297	glycogen (starch) synthase activity
BSR23_RS12210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BSR23_RS12215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BSR23_RS12225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BSR23_RS12235	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BSR23_RS12240	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BSR23_RS12245	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BSR23_RS12255	COG0542	response to heat
BSR23_RS12260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BSR23_RS12265	COG1278	Cold shock
BSR23_RS12275	COG1187	pseudouridine synthase activity
BSR23_RS12280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
BSR23_RS12290	COG1199	ATP-dependent helicase activity
BSR23_RS12295	COG0730	response to heat
BSR23_RS12300	COG3923	Primosomal replication protein n
BSR23_RS12310	COG0708	Exodeoxyribonuclease III
BSR23_RS12355	COG1882	Formate acetyltransferase
BSR23_RS12365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BSR23_RS12375	COG3013	Belongs to the UPF0304 family
BSR23_RS12385	COG2766	serine protein kinase
BSR23_RS12390	COG2718	Belongs to the UPF0229 family
BSR23_RS12400	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BSR23_RS12410	COG1663	tetraacyldisaccharide 4'-kinase activity
BSR23_RS12415	COG1132	(ABC) transporter
BSR23_RS12420	COG2333	competence protein COMEC
BSR23_RS12420	COG0658	competence protein
BSR23_RS12430	COG4591	ABC-type transport system involved in lipoprotein release permease component
BSR23_RS12435	COG1136	(ABC) transporter
BSR23_RS12440	COG4591	ABC-type transport system involved in lipoprotein release permease component
BSR23_RS12450	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BSR23_RS12465	COG1252	NADH dehydrogenase
BSR23_RS12475	COG3150	esterase
BSR23_RS12500	COG0537	adenosine 5'-monophosphoramidase activity
BSR23_RS12530	COG0516	GMP reductase activity
BSR23_RS12530	COG0517	IMP dehydrogenase activity
BSR23_RS12540	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BSR23_RS12545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BSR23_RS12550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSR23_RS12560	COG2199	diguanylate cyclase activity
BSR23_RS12575	COG3126	Type III secretion system lipoprotein chaperone (YscW)
BSR23_RS12580	COG1946	Acyl-CoA thioesterase
BSR23_RS12590	COG1522	sequence-specific DNA binding
BSR23_RS12620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSR23_RS12625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR23_RS12650	COG0477	Major facilitator Superfamily
BSR23_RS12655	COG2855	membrane
BSR23_RS12675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BSR23_RS12680	COG0596	Alpha beta hydrolase
BSR23_RS12685	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BSR23_RS12690	COG1169	isochorismate synthase
BSR23_RS12695	COG0436	Aminotransferase
BSR23_RS12700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BSR23_RS12705	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BSR23_RS12720	COG1555	photosystem II stabilization
BSR23_RS12725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSR23_RS12730	COG0776	regulation of translation
BSR23_RS12735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BSR23_RS12740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BSR23_RS12750	COG0544	peptidyl-prolyl cis-trans isomerase activity
BSR23_RS12760	COG2204	response regulator
BSR23_RS12770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BSR23_RS12775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BSR23_RS12780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BSR23_RS12805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BSR23_RS12810	COG0569	domain protein
BSR23_RS12815	COG0513	Belongs to the DEAD box helicase family
BSR23_RS12820	COG1253	flavin adenine dinucleotide binding
BSR23_RS12855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BSR23_RS12860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BSR23_RS12875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BSR23_RS12880	COG1216	Glycosyl transferase, family 2
BSR23_RS12885	COG2986	histidine ammonia-lyase
BSR23_RS12910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BSR23_RS12920	COG1028	Short-chain dehydrogenase reductase Sdr
BSR23_RS12940	COG3550	peptidyl-serine autophosphorylation
BSR23_RS12945	COG1396	sequence-specific DNA binding
BSR23_RS13020	COG0732	type I restriction modification DNA specificity domain
BSR23_RS13035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BSR23_RS13040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BSR23_RS13045	COG0583	DNA-binding transcription factor activity
BSR23_RS13050	COG2951	lytic endotransglycosylase activity
BSR23_RS13055	COG3100	YcgL domain-containing protein
BSR23_RS13060	COG0850	regulation of cytokinetic process
BSR23_RS13065	COG2894	cell division
BSR23_RS13070	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BSR23_RS13075	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BSR23_RS13080	COG0318	PFAM AMP-dependent synthetase and ligase
BSR23_RS13085	COG2267	carboxylic ester hydrolase activity
BSR23_RS13100	COG1214	PFAM Peptidase M22, glycoprotease
BSR23_RS13105	COG1199	ATP-dependent helicase activity
BSR23_RS13110	COG0788	formyltetrahydrofolate deformylase activity
BSR23_RS13125	COG3102	Protein conserved in bacteria
BSR23_RS13135	COG0018	arginyl-trna synthetase
BSR23_RS13155	COG1918	ferrous iron import across plasma membrane
BSR23_RS13170	COG4977	sequence-specific DNA binding
BSR23_RS13175	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BSR23_RS13180	COG1121	(ABC) transporter
BSR23_RS13185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BSR23_RS13195	COG0045	succinate-CoA ligase (ADP-forming) activity
BSR23_RS13200	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSR23_RS13205	COG0567	Dehydrogenase, E1 component
BSR23_RS13210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BSR23_RS13215	COG1053	succinate dehydrogenase
BSR23_RS13220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BSR23_RS13235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BSR23_RS13245	COG0033	Phosphoglucomutase
BSR23_RS13250	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BSR23_RS13255	COG0596	Alpha beta hydrolase
BSR23_RS13275	COG0735	belongs to the Fur family
BSR23_RS13280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BSR23_RS13285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR23_RS13285	COG1263	PTS System
BSR23_RS13295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BSR23_RS13300	COG1940	carbohydrate kinase activity
BSR23_RS13300	COG1846	Transcriptional regulator
BSR23_RS13305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BSR23_RS13305	COG4651	solute:proton antiporter activity
BSR23_RS13310	COG0367	asparagine synthase
BSR23_RS13315	COG0250	Participates in transcription elongation, termination and antitermination
BSR23_RS13320	COG3104	oligopeptide transport
BSR23_RS13325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BSR23_RS13330	COG0563	adenylate kinase activity
BSR23_RS13335	COG0326	Molecular chaperone. Has ATPase activity
BSR23_RS13340	COG3710	Transcriptional regulator
BSR23_RS13360	COG0622	Phosphoesterase
BSR23_RS13390	COG1090	epimerase
BSR23_RS13395	COG0300	oxidoreductase activity
BSR23_RS13405	COG3118	belongs to the thioredoxin family
BSR23_RS13410	COG0330	HflC and HflK could
BSR23_RS13435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BSR23_RS13440	COG3115	cell septum assembly
BSR23_RS13445	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
BSR23_RS13450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BSR23_RS13460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR23_RS13465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BSR23_RS13470	COG2190	(PTS) system
BSR23_RS13480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR23_RS13485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR23_RS13495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR23_RS13505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR23_RS13515	COG3951	Flagellar rod assembly protein muramidase FlgJ
BSR23_RS13515	COG1705	Flagellar rod assembly protein muramidase FlgJ
BSR23_RS13520	COG1706	bacterial-type flagellum-dependent cell motility
BSR23_RS13525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BSR23_RS13535	COG4787	bacterial-type flagellum-dependent cell motility
BSR23_RS13545	COG1749	Flagellar hook protein flgE
BSR23_RS13555	COG1558	bacterial-type flagellum-dependent cell motility
BSR23_RS13560	COG1815	bacterial-type flagellum-dependent cell motility
BSR23_RS13565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BSR23_RS13570	COG0835	chemotaxis
BSR23_RS13570	COG0784	Response regulator, receiver
BSR23_RS13630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BSR23_RS13635	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
BSR23_RS13650	COG2608	mercury ion transmembrane transporter activity
BSR23_RS13650	COG2217	Heavy metal translocating P-type atpase
BSR23_RS13690	COG2840	Smr protein MutS2
BSR23_RS13695	COG1187	pseudouridine synthase activity
BSR23_RS13705	COG0737	Belongs to the 5'-nucleotidase family
BSR23_RS13710	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BSR23_RS13715	COG2912	Transglutaminase-like superfamily
BSR23_RS13720	COG3094	Invasion gene expression up-regulator, SirB
BSR23_RS13725	COG2890	protein-(glutamine-N5) methyltransferase activity
BSR23_RS13730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BSR23_RS13735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BSR23_RS13740	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BSR23_RS13745	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BSR23_RS13750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BSR23_RS13755	COG0193	aminoacyl-tRNA hydrolase activity
BSR23_RS13760	COG0012	GTP binding
BSR23_RS13875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BSR23_RS13885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BSR23_RS13890	COG1702	phosphate starvation-inducible protein PhoH
BSR23_RS13895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BSR23_RS13900	COG4535	Mg2 and Co2 transporter CorC
BSR23_RS13905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BSR23_RS13910	COG2888	peptidyl-tyrosine sulfation
BSR23_RS13915	COG0495	leucyl-tRNA aminoacylation
BSR23_RS13920	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BSR23_RS13925	COG1466	dna polymerase III delta subunit
BSR23_RS13930	COG0799	negative regulation of ribosome biogenesis
BSR23_RS13935	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BSR23_RS13940	COG0768	penicillin binding
BSR23_RS13945	COG0772	Belongs to the SEDS family
BSR23_RS13950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BSR23_RS13955	COG1686	Belongs to the peptidase S11 family
BSR23_RS13960	COG2921	Belongs to the UPF0250 family
BSR23_RS13965	COG0321	lipoyl(octanoyl) transferase activity
BSR23_RS13970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BSR23_RS13975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BSR23_RS13980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSR23_RS13995	COG0366	Alpha amylase catalytic
BSR23_RS14000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR23_RS14000	COG1263	PTS System
BSR23_RS14010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BSR23_RS14020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BSR23_RS14025	COG2011	ABC-type metal ion transport system permease component
BSR23_RS14030	COG1464	Belongs to the NlpA lipoprotein family
BSR23_RS14035	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
BSR23_RS14045	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BSR23_RS14045	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BSR23_RS14060	COG1611	Belongs to the LOG family
BSR23_RS14065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSR23_RS14075	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BSR23_RS14080	COG2363	Small membrane protein
BSR23_RS14090	COG0583	DNA-binding transcription factor activity
BSR23_RS14095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BSR23_RS14095	COG0301	tRNA thio-modification
BSR23_RS14100	COG2885	chlorophyll binding
BSR23_RS14105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BSR23_RS14110	COG1722	exodeoxyribonuclease VII activity
BSR23_RS14115	COG0142	geranyltranstransferase activity
BSR23_RS14120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BSR23_RS14125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BSR23_RS14130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BSR23_RS14135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSR23_RS14155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSR23_RS14155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSR23_RS14160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BSR23_RS14165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BSR23_RS14170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BSR23_RS14180	COG1073	alpha beta
BSR23_RS14185	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BSR23_RS14190	COG2252	PERMEase
BSR23_RS14195	COG2195	Cleaves the N-terminal amino acid of tripeptides
BSR23_RS14220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BSR23_RS14220	COG0047	phosphoribosylformylglycinamidine synthase activity
BSR23_RS14230	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BSR23_RS14245	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BSR23_RS14285	COG0484	heat shock protein binding
BSR23_RS14290	COG0443	Heat shock 70 kDa protein
BSR23_RS14300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BSR23_RS14305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BSR23_RS14315	COG0497	DNA recombination
BSR23_RS14320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BSR23_RS14325	COG2914	Belongs to the UPF0125 (RnfH) family
BSR23_RS14330	COG2867	negative regulation of translational initiation
BSR23_RS14335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BSR23_RS14350	COG0328	RNA-DNA hybrid ribonuclease activity
BSR23_RS14390	COG0583	DNA-binding transcription factor activity
BSR23_RS14395	COG3153	acetyltransferase
BSR23_RS14395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSR23_RS14415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BSR23_RS14420	COG2873	o-acetylhomoserine
BSR23_RS14460	COG1115	amino acid carrier protein
BSR23_RS14470	COG1584	GPR1 FUN34 yaaH family protein
BSR23_RS14480	COG1757	Na H antiporter
BSR23_RS14495	COG3706	GGDEF domain
BSR23_RS14505	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BSR23_RS14555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BSR23_RS14555	COG0519	Catalyzes the synthesis of GMP from XMP
BSR23_RS14560	COG0517	IMP dehydrogenase activity
BSR23_RS14560	COG0516	GMP reductase activity
BSR23_RS14565	COG1570	exodeoxyribonuclease VII activity
BSR23_RS14580	COG1160	GTP binding
BSR23_RS14585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BSR23_RS14590	COG2976	Protein conserved in bacteria
BSR23_RS14595	COG0124	histidyl-tRNA synthetase
BSR23_RS14600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BSR23_RS14615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BSR23_RS14620	COG0105	UTP biosynthetic process
BSR23_RS14625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BSR23_RS14630	COG2975	iron-sulfur cluster assembly
BSR23_RS14635	COG0633	Ferredoxin
BSR23_RS14640	COG0443	Heat shock 70 kDa protein
BSR23_RS14645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BSR23_RS14655	COG0822	iron-sulfur transferase activity
BSR23_RS14660	COG1104	cysteine desulfurase activity
BSR23_RS14675	COG0483	inositol monophosphate 1-phosphatase activity
BSR23_RS14685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSR23_RS14690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSR23_RS14695	COG1862	Preprotein translocase
BSR23_RS14700	COG0343	queuine tRNA-ribosyltransferase activity
BSR23_RS14705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BSR23_RS14720	COG0517	IMP dehydrogenase activity
BSR23_RS14730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BSR23_RS14740	COG0583	DNA-binding transcription factor activity
BSR23_RS14745	COG0450	alkyl hydroperoxide reductase
BSR23_RS14755	COG3142	Participates in the control of copper homeostasis
BSR23_RS14765	COG0704	Plays a role in the regulation of phosphate uptake
BSR23_RS14770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSR23_RS14775	COG0581	inorganic phosphate transmembrane transporter activity
BSR23_RS14785	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BSR23_RS14790	COG0248	Ppx GppA phosphatase
BSR23_RS14800	COG5002	protein histidine kinase activity
BSR23_RS14805	COG0745	RESPONSE REGULATOR receiver
BSR23_RS14815	COG2974	May be involved in recombination
BSR23_RS14820	COG0826	peptidase U32
BSR23_RS14825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BSR23_RS14885	COG0542	response to heat
BSR23_RS14895	COG0564	pseudouridine synthase activity
BSR23_RS14900	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BSR23_RS14905	COG0741	lytic transglycosylase activity
BSR23_RS14910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BSR23_RS14915	COG1605	Chorismate mutase
BSR23_RS14915	COG0077	Prephenate dehydratase
BSR23_RS14920	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BSR23_RS14925	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
BSR23_RS14935	COG0488	(ABC) transporter
BSR23_RS14950	COG0739	heme binding
BSR23_RS14955	COG0287	Prephenate dehydrogenase
BSR23_RS14955	COG1605	Chorismate mutase
BSR23_RS14960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BSR23_RS14965	COG1472	Belongs to the glycosyl hydrolase 3 family
BSR23_RS14970	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BSR23_RS14975	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BSR23_RS14990	COG1966	Carbon starvation protein
BSR23_RS14995	COG3275	phosphorelay sensor kinase activity
BSR23_RS15000	COG3279	Response regulator of the LytR AlgR family
BSR23_RS15005	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BSR23_RS15010	COG1047	Peptidyl-prolyl cis-trans
BSR23_RS15015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BSR23_RS15020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BSR23_RS15025	COG0196	riboflavin kinase activity
BSR23_RS15030	COG0728	peptidoglycan biosynthetic process
BSR23_RS15035	COG0268	Binds directly to 16S ribosomal RNA
BSR23_RS15045	COG0640	Transcriptional regulator
BSR23_RS15055	COG0583	DNA-binding transcription factor activity
BSR23_RS15060	COG1283	sodium-dependent phosphate transmembrane transporter activity
BSR23_RS15070	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BSR23_RS15075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BSR23_RS15080	COG0730	response to heat
BSR23_RS15090	COG0494	nUDIX hydrolase
BSR23_RS15100	COG3066	DNA modification
BSR23_RS15110	COG0667	Aldo Keto reductase
BSR23_RS15125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BSR23_RS15135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BSR23_RS15140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BSR23_RS15145	COG4974	Belongs to the 'phage' integrase family
BSR23_RS15150	COG0716	FMN binding
BSR23_RS15160	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BSR23_RS15165	COG0513	Belongs to the DEAD box helicase family
BSR23_RS15170	COG3022	response to hydroperoxide
BSR23_RS15175	COG1115	amino acid carrier protein
BSR23_RS15190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BSR23_RS15200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BSR23_RS15205	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
BSR23_RS15210	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BSR23_RS15215	COG0083	homoserine kinase activity
BSR23_RS15230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BSR23_RS15245	COG0745	RESPONSE REGULATOR receiver
BSR23_RS15255	COG0784	Response regulator, receiver
BSR23_RS15255	COG5002	protein histidine kinase activity
BSR23_RS15255	COG2198	Histidine kinase
BSR23_RS15260	COG5001	Diguanylate cyclase
BSR23_RS15260	COG2203	Gaf domain
BSR23_RS15260	COG3706	GGDEF domain
BSR23_RS15260	COG4251	negative regulation of phosphorylation
BSR23_RS15265	COG1242	4 iron, 4 sulfur cluster binding
BSR23_RS15270	COG0067	glutamate synthase
BSR23_RS15270	COG0069	glutamate synthase activity
BSR23_RS15270	COG0070	glutamate synthase
BSR23_RS15280	COG0070	glutamate synthase
BSR23_RS15280	COG0067	glutamate synthase
BSR23_RS15280	COG0069	glutamate synthase activity
BSR23_RS15285	COG0493	'glutamate synthase
BSR23_RS15295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BSR23_RS15305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSR23_RS15310	COG2860	membrane
BSR23_RS15315	COG0583	DNA-binding transcription factor activity
BSR23_RS15320	COG0730	response to heat
BSR23_RS15335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BSR23_RS15340	COG0505	Belongs to the CarA family
BSR23_RS15345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BSR23_RS15350	COG0494	nUDIX hydrolase
BSR23_RS15355	COG0653	protein targeting
BSR23_RS15365	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BSR23_RS15370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BSR23_RS15375	COG0849	cell division
BSR23_RS15380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BSR23_RS15385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BSR23_RS15390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BSR23_RS15395	COG0772	Belongs to the SEDS family
BSR23_RS15400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BSR23_RS15405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BSR23_RS15410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BSR23_RS15415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BSR23_RS15420	COG0768	penicillin binding
BSR23_RS15425	COG3116	cell division
BSR23_RS15430	COG0275	rRNA processing
BSR23_RS15445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BSR23_RS15455	COG0792	nuclease activity
BSR23_RS15460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BSR23_RS15465	COG2823	Periplasmic or secreted lipoprotein
BSR23_RS15470	COG2969	positive regulation of protein catabolic process
BSR23_RS15475	COG0625	glutathione transferase activity
BSR23_RS15480	COG2857	Cytochrome c1
BSR23_RS15485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BSR23_RS15490	COG0723	plastoquinol--plastocyanin reductase activity
BSR23_RS15495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BSR23_RS15500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BSR23_RS15510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BSR23_RS15520	COG3105	Protein conserved in bacteria
BSR23_RS15530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSR23_RS15535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BSR23_RS15545	COG3150	esterase
BSR23_RS15555	COG3151	Protein conserved in bacteria
BSR23_RS15560	COG0494	nUDIX hydrolase
BSR23_RS15565	COG1538	Outer membrane efflux protein
BSR23_RS15570	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BSR23_RS15570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BSR23_RS15575	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BSR23_RS15590	COG3025	triphosphatase activity
BSR23_RS15595	COG1392	Phosphate transport regulator
BSR23_RS15600	COG0306	phosphate transporter
BSR23_RS15605	COG4991	sh3 domain protein
BSR23_RS15615	COG3267	Type II secretory pathway component ExeA
BSR23_RS15615	COG3409	Peptidoglycan-binding domain 1 protein
BSR23_RS15620	COG0617	tRNA 3'-terminal CCA addition
BSR23_RS15625	COG1968	undecaprenyl-diphosphatase activity
BSR23_RS15630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BSR23_RS15635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BSR23_RS15640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BSR23_RS15645	COG0596	Alpha beta hydrolase
BSR23_RS15650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BSR23_RS15655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BSR23_RS15660	COG1610	YqeY-like protein
BSR23_RS15665	COG0358	DNA primase activity
BSR23_RS15715	COG0582	viral genome integration into host DNA
BSR23_RS15720	COG1464	Belongs to the NlpA lipoprotein family
BSR23_RS15755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR23_RS15755	COG2213	PTS system mannitol-specific
BSR23_RS15760	COG0246	Mannitol dehydrogenase
BSR23_RS15765	COG3722	fumarate hydratase activity
BSR23_RS15780	COG1461	Dihydroxyacetone kinase
BSR23_RS15785	COG2376	Dihydroxyacetone kinase
BSR23_RS15795	COG5002	protein histidine kinase activity
BSR23_RS15810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BSR23_RS15815	COG1349	DNA-binding transcription factor activity
BSR23_RS15825	COG0469	pyruvate kinase activity
BSR23_RS15840	COG0440	acetolactate synthase activity
BSR23_RS15845	COG0028	Belongs to the TPP enzyme family
BSR23_RS15850	COG1022	Amp-dependent synthetase and ligase
BSR23_RS15855	COG0583	DNA-binding transcription factor activity
BSR23_RS15875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSR23_RS15880	COG0473	3-isopropylmalate dehydrogenase activity
BSR23_RS15885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BSR23_RS15890	COG0066	3-isopropylmalate dehydratase activity
BSR23_RS15900	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BSR23_RS15905	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BSR23_RS15910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSR23_RS15915	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BSR23_RS15920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BSR23_RS15925	COG2967	ApaG domain
BSR23_RS15930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BSR23_RS15945	COG2966	Psort location CytoplasmicMembrane, score
BSR23_RS15950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BSR23_RS15960	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BSR23_RS15965	COG0142	geranyltranstransferase activity
BSR23_RS15975	COG0039	L-malate dehydrogenase activity
BSR23_RS15990	COG2358	TRAP transporter, solute receptor (TAXI family
BSR23_RS16010	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BSR23_RS16015	COG1178	ABC-type Fe3 transport system permease component
BSR23_RS16020	COG4143	(ABC) transporter
BSR23_RS16025	COG0163	prenyltransferase activity
BSR23_RS16030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BSR23_RS16040	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BSR23_RS16045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BSR23_RS16055	COG2105	PFAM AIG2 family protein
BSR23_RS16065	COG0729	surface antigen
BSR23_RS16070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSR23_RS16080	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BSR23_RS16095	COG4181	ATPase activity
BSR23_RS16115	COG0529	Catalyzes the synthesis of activated sulfate
BSR23_RS16120	COG0471	metal ion transport
BSR23_RS16120	COG3273	potassium ion transport
BSR23_RS16130	COG2895	sulfate adenylyltransferase (ATP) activity
BSR23_RS16135	COG0175	sulfate reduction
BSR23_RS16140	COG1648	precorrin-2 dehydrogenase activity
BSR23_RS16140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BSR23_RS16145	COG0737	Belongs to the 5'-nucleotidase family
BSR23_RS16155	COG0513	Belongs to the DEAD box helicase family
BSR23_RS16160	COG2153	protein acetylation
BSR23_RS16170	COG0545	Peptidyl-prolyl cis-trans isomerase
BSR23_RS16180	COG0203	ribosomal protein L17
BSR23_RS16185	COG0202	RNA polymerase activity
BSR23_RS16195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BSR23_RS16200	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BSR23_RS16205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BSR23_RS16210	COG0201	protein transport
BSR23_RS16215	COG0200	Binds to the 23S rRNA
BSR23_RS16220	COG1841	ribosomal large subunit assembly
BSR23_RS16235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BSR23_RS16240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BSR23_RS16245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BSR23_RS16250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BSR23_RS16255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BSR23_RS16260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BSR23_RS16265	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BSR23_RS16270	COG0255	Belongs to the universal ribosomal protein uL29 family
BSR23_RS16280	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BSR23_RS16285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BSR23_RS16290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BSR23_RS16295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BSR23_RS16305	COG0088	Forms part of the polypeptide exit tunnel
BSR23_RS16310	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BSR23_RS16320	COG0254	rRNA binding
BSR23_RS16330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BSR23_RS16335	COG1609	Transcriptional regulator
BSR23_RS16345	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BSR23_RS16350	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BSR23_RS16365	COG2003	Belongs to the UPF0758 family
BSR23_RS16395	COG1575	Belongs to the MenA family. Type 1 subfamily
BSR23_RS16400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BSR23_RS16405	COG3074	FtsZ-dependent cytokinesis
BSR23_RS16415	COG1494	fructose-1,6-bisphosphatase
BSR23_RS16440	COG0149	triose-phosphate isomerase activity
BSR23_RS16460	COG2801	Transposase and inactivated derivatives
BSR23_RS16500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BSR23_RS16510	COG1482	cell wall glycoprotein biosynthetic process
BSR23_RS16530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BSR23_RS16535	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BSR23_RS16545	COG0463	Glycosyl transferase, family 2
BSR23_RS16620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BSR23_RS16630	COG1560	Kdo2-lipid A biosynthetic process
BSR23_RS16635	COG0859	PFAM glycosyl transferase family 9
BSR23_RS16640	COG1519	Transferase
BSR23_RS16655	COG0438	transferase activity, transferring glycosyl groups
BSR23_RS16655	COG0297	glycogen (starch) synthase activity
BSR23_RS16675	COG2030	dehydratase
BSR23_RS16680	COG0110	maltose O-acetyltransferase activity
BSR23_RS16700	COG3642	lipopolysaccharide core region biosynthetic process
BSR23_RS16705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BSR23_RS16710	COG0859	PFAM glycosyl transferase family 9
BSR23_RS16715	COG0463	Glycosyl transferase, family 2
BSR23_RS16730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BSR23_RS16735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BSR23_RS16750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BSR23_RS16755	COG2003	Belongs to the UPF0758 family
BSR23_RS16770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BSR23_RS16775	COG1309	transcriptional regulator
BSR23_RS16780	COG1560	Kdo2-lipid A biosynthetic process
BSR23_RS16785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BSR23_RS16790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BSR23_RS16795	COG1561	YicC-like family, N-terminal region
BSR23_RS16805	COG4608	Belongs to the ABC transporter superfamily
BSR23_RS16810	COG0444	Belongs to the ABC transporter superfamily
BSR23_RS16815	COG0747	negative chemotaxis
BSR23_RS16820	COG4239	(ABC) transporter, permease
BSR23_RS16825	COG4174	ABC transporter (Permease)
BSR23_RS16850	COG0811	peptide transport
BSR23_RS16855	COG0848	biopolymer transport protein
BSR23_RS16870	COG0194	GDP metabolic process
BSR23_RS16875	COG1758	RNA polymerase activity
BSR23_RS16880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BSR23_RS16885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSR23_RS16890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BSR23_RS16900	COG2233	PERMEase
BSR23_RS16920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BSR23_RS16930	COG2183	response to ionizing radiation
BSR23_RS16940	COG0596	Alpha beta hydrolase
BSR23_RS16945	COG1040	competence protein
BSR23_RS16950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BSR23_RS16950	COG0316	Belongs to the HesB IscA family
BSR23_RS16955	COG0494	nUDIX hydrolase
BSR23_RS16960	COG1218	3'(2'),5'-bisphosphate nucleotidase
BSR23_RS16970	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BSR23_RS16975	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BSR23_RS16980	COG3156	type II secretion system protein K
BSR23_RS16985	COG4795	General secretion pathway protein
BSR23_RS16990	COG2165	general secretion pathway protein
BSR23_RS16995	COG2165	general secretion pathway protein
BSR23_RS17000	COG2165	general secretion pathway protein
BSR23_RS17005	COG1459	type II secretion system
BSR23_RS17010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BSR23_RS17020	COG3031	protein transport across the cell outer membrane
BSR23_RS17025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BSR23_RS17030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BSR23_RS17035	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BSR23_RS17045	COG0456	acetyltransferase
BSR23_RS17050	COG1490	D-aminoacyl-tRNA deacylase activity
BSR23_RS17055	COG1295	ribonuclease BN
BSR23_RS17070	COG1217	gtp-binding protein TYPA
BSR23_RS17075	COG0174	glutamine synthetase
BSR23_RS17085	COG3852	Histidine kinase
BSR23_RS17090	COG2204	response regulator
BSR23_RS17100	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BSR23_RS17135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BSR23_RS17145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSR23_RS17145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSR23_RS17170	COG0084	hydrolase, TatD family'
BSR23_RS17180	COG0805	protein transport
BSR23_RS17185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSR23_RS17190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSR23_RS17195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BSR23_RS17205	COG2226	methyltransferase
BSR23_RS17210	COG1322	Protein conserved in bacteria
BSR23_RS17225	COG0628	permease
BSR23_RS17285	COG2081	HI0933 family
BSR23_RS17295	COG1528	Iron-storage protein
BSR23_RS17300	COG0589	response to stress
BSR23_RS17315	COG0742	ribosomal rna small subunit methyltransferase
BSR23_RS17320	COG5002	protein histidine kinase activity
BSR23_RS17320	COG5001	Diguanylate cyclase
BSR23_RS17325	COG1522	sequence-specific DNA binding
BSR23_RS17330	COG0339	signal peptide processing
BSR23_RS17340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BSR23_RS17345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSR23_RS17350	COG0583	DNA-binding transcription factor activity
BSR23_RS17355	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BSR23_RS17360	COG0800	Aldolase
BSR23_RS17365	COG2610	gluconate transmembrane transporter activity
BSR23_RS17370	COG3265	gluconokinase activity
BSR23_RS17375	COG0129	dihydroxy-acid dehydratase activity
BSR23_RS17390	COG0583	DNA-binding transcription factor activity
BSR23_RS17395	COG1609	Transcriptional regulator
BSR23_RS17435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSR23_RS17440	COG0601	transmembrane transport
BSR23_RS17445	COG0747	negative chemotaxis
BSR23_RS17450	COG4172	Belongs to the ABC transporter superfamily
BSR23_RS17515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR23_RS17520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSR23_RS17530	COG2960	long-chain fatty acid transporting porin activity
BSR23_RS17535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BSR23_RS17540	COG0583	DNA-binding transcription factor activity
BSR23_RS17560	COG3547	Transposase (IS116 IS110 IS902 family)
BSR23_RS17605	COG1349	DNA-binding transcription factor activity
BSR23_RS17610	COG0738	Major facilitator superfamily
BSR23_RS17615	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
BSR23_RS17625	COG4154	Belongs to the RbsD FucU family
BSR23_RS17630	COG0235	Class ii aldolase
BSR23_RS17645	COG2003	Belongs to the UPF0758 family
BSR23_RS17685	COG0641	radical SAM
BSR23_RS17700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BSR23_RS17720	COG1214	PFAM Peptidase M22, glycoprotease
BSR23_RS17720	COG0456	acetyltransferase
BSR23_RS17730	COG3069	C4-dicarboxylate transmembrane transporter activity
BSR23_RS17735	COG1704	LemA family
BSR23_RS17740	COG0501	Belongs to the peptidase M48B family
BSR23_RS17770	COG0641	radical SAM
BSR23_RS17790	COG3111	PFAM Bacterial OB fold (BOF) protein
BSR23_RS17795	COG1597	lipid kinase activity
BSR23_RS17800	COG0583	DNA-binding transcription factor activity
BSR23_RS17805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSR23_RS17835	COG0714	Associated with various cellular activities
BSR23_RS17840	COG0641	radical SAM
BSR23_RS17845	COG3119	arylsulfatase activity
BSR23_RS17860	COG3119	arylsulfatase activity
BSR23_RS17865	COG3119	arylsulfatase activity
BSR23_RS17885	COG2205	protein histidine kinase activity
BSR23_RS17885	COG2198	Histidine kinase
BSR23_RS17885	COG0784	Response regulator, receiver
BSR23_RS17890	COG1879	ABC-type sugar transport system periplasmic component
BSR23_RS17895	COG1803	Methylglyoxal synthase
BSR23_RS17900	COG0210	DNA helicase
BSR23_RS17905	COG1289	transmembrane transporter activity
BSR23_RS17940	COG1629	transport
BSR23_RS17940	COG4771	TonB-dependent receptor
BSR23_RS17945	COG2207	Transcriptional regulator
BSR23_RS17955	COG0789	Transcriptional regulator
BSR23_RS17960	COG4604	ABC transporter, ATP-binding protein
BSR23_RS17965	COG4605	iron ion homeostasis
BSR23_RS17970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR23_RS17975	COG4607	ABC-type enterochelin transport system periplasmic component
BSR23_RS18000	COG2847	Copper chaperone PCu(A)C
BSR23_RS18005	COG0443	Heat shock 70 kDa protein
BSR23_RS18045	COG0625	glutathione transferase activity
BSR23_RS18060	COG4160	amino acid transport
BSR23_RS18065	COG4215	(ABC) transporter
BSR23_RS18070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR23_RS18075	COG1126	abc transporter atp-binding protein
BSR23_RS18105	COG1902	pentaerythritol trinitrate reductase activity
BSR23_RS18120	COG0109	protoheme IX farnesyltransferase activity
BSR23_RS18125	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BSR23_RS18130	COG1845	cytochrome c oxidase, subunit III
BSR23_RS18135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BSR23_RS18140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BSR23_RS18145	COG1028	Short-chain dehydrogenase reductase Sdr
BSR23_RS18155	COG1024	Enoyl-CoA hydratase
BSR23_RS18160	COG1024	Enoyl-CoA hydratase
BSR23_RS18165	COG1960	acyl-CoA dehydrogenase activity
BSR23_RS18175	COG0183	Belongs to the thiolase family
BSR23_RS18185	COG1960	acyl-CoA dehydrogenase activity
BSR23_RS18190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BSR23_RS18195	COG1024	Enoyl-CoA hydratase
BSR23_RS18205	COG5413	integral membrane protein
BSR23_RS18220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BSR23_RS18230	COG5001	Diguanylate cyclase
BSR23_RS18235	COG0513	Belongs to the DEAD box helicase family
BSR23_RS18240	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
BSR23_RS18255	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BSR23_RS18275	COG0641	radical SAM
BSR23_RS18300	COG0840	transmembrane signaling receptor activity
BSR23_RS18305	COG1119	ATPase activity
BSR23_RS18310	COG2200	EAL domain
BSR23_RS18330	COG0513	Belongs to the DEAD box helicase family
BSR23_RS18335	COG0523	cobalamin synthesis protein
BSR23_RS18345	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BSR23_RS18355	COG0133	tryptophan synthase activity
BSR23_RS18360	COG4628	conserved protein (DUF2132)
BSR23_RS18365	COG0513	Belongs to the DEAD box helicase family
BSR23_RS18370	COG3530	Putative quorum-sensing-regulated virulence factor
BSR23_RS18395	COG2154	pterin-4-alpha-carbinolamine dehydratase
BSR23_RS18400	COG3186	Phenylalanine-4-hydroxylase
BSR23_RS18405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSR23_RS18410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BSR23_RS18450	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BSR23_RS18455	COG1454	alcohol dehydrogenase
BSR23_RS18460	COG2133	pyrroloquinoline quinone binding
BSR23_RS18470	COG0783	Belongs to the Dps family
BSR23_RS18475	COG0840	transmembrane signaling receptor activity
BSR23_RS18485	COG1136	(ABC) transporter
BSR23_RS18485	COG0577	efflux transmembrane transporter activity
BSR23_RS18505	COG2199	diguanylate cyclase activity
BSR23_RS18520	COG3036	rescue of stalled ribosome
BSR23_RS18525	COG1278	Cold shock
BSR23_RS18560	COG0545	Peptidyl-prolyl cis-trans isomerase
BSR23_RS18565	COG0109	protoheme IX farnesyltransferase activity
BSR23_RS18570	COG1612	heme a metabolic process
BSR23_RS18595	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BSR23_RS18605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BSR23_RS18610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BSR23_RS18620	COG1280	lysine exporter protein (LysE YggA)
BSR23_RS18625	COG2207	Transcriptional regulator
BSR23_RS18655	COG0697	spore germination
BSR23_RS18680	COG2814	Major facilitator Superfamily
BSR23_RS18685	COG0583	DNA-binding transcription factor activity
BSR23_RS18690	COG5001	Diguanylate cyclase
BSR23_RS18695	COG0739	heme binding
BSR23_RS18720	COG3314	Sporulation integral membrane protein YlbJ
BSR23_RS18735	COG0814	amino acid
BSR23_RS18755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BSR23_RS18760	COG1072	(Pantothenic acid kinase))
BSR23_RS18770	COG1063	alcohol dehydrogenase
BSR23_RS18775	COG2213	PTS system mannitol-specific
BSR23_RS18780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR23_RS18800	COG0798	PFAM Bile acid sodium symporter
BSR23_RS18810	COG1881	PFAM PEBP family protein
BSR23_RS18840	COG1131	(ABC) transporter
BSR23_RS18845	COG0842	Transport permease protein
BSR23_RS18860	COG3383	formate dehydrogenase (NAD+) activity
BSR23_RS18885	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSR23_RS18915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR23_RS18925	COG2067	long-chain fatty acid transport protein
BSR23_RS18935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR23_RS18945	COG1505	serine-type exopeptidase activity
BSR23_RS18950	COG0488	(ABC) transporter
BSR23_RS18955	COG0589	response to stress
BSR23_RS18960	COG2249	NAD(P)H dehydrogenase (quinone) activity
BSR23_RS18980	COG0366	Alpha amylase catalytic
BSR23_RS19005	COG0583	DNA-binding transcription factor activity
BSR23_RS19015	COG0783	Belongs to the Dps family
BSR23_RS19020	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BSR23_RS19045	COG2211	Major facilitator Superfamily
BSR23_RS19050	COG3940	Belongs to the glycosyl hydrolase 43 family
BSR23_RS19055	COG2017	converts alpha-aldose to the beta-anomer
BSR23_RS19065	COG0561	phosphatase activity
BSR23_RS19070	COG2160	L-arabinose isomerase activity
BSR23_RS19080	COG1069	ribulokinase activity
BSR23_RS19085	COG2211	Major facilitator Superfamily
BSR23_RS19100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSR23_RS19110	COG0784	Response regulator, receiver
BSR23_RS19110	COG0835	chemotaxis
BSR23_RS19120	COG0748	coenzyme F420 binding
BSR23_RS19125	COG3721	Heme iron utilization protein
BSR23_RS19135	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BSR23_RS19140	COG0811	peptide transport
BSR23_RS19145	COG0848	biopolymer transport protein
BSR23_RS19155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR23_RS19160	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BSR23_RS19205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BSR23_RS19210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BSR23_RS19215	COG0633	Ferredoxin
BSR23_RS19215	COG3217	Mosc domain protein beta barrel domain protein
BSR23_RS19215	COG0633	Ferredoxin
BSR23_RS19215	COG3217	Mosc domain protein beta barrel domain protein
BSR23_RS19225	COG0401	homolog of Blt101
BSR23_RS19235	COG0418	dihydroorotase activity
BSR23_RS19240	COG2354	Protein conserved in bacteria
BSR23_RS19270	COG2207	Transcriptional regulator
BSR23_RS19270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSR23_RS19275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR23_RS19320	COG0513	Belongs to the DEAD box helicase family
BSR23_RS19330	COG0583	DNA-binding transcription factor activity
BSR23_RS19345	COG1902	pentaerythritol trinitrate reductase activity
BSR23_RS19350	COG1063	alcohol dehydrogenase
BSR23_RS19375	COG3122	Protein conserved in bacteria
BSR23_RS19390	COG0583	DNA-binding transcription factor activity
BSR23_RS19395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BSR23_RS19400	COG0252	asparaginase activity
BSR23_RS19405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BSR23_RS19410	COG0574	Belongs to the PEP-utilizing enzyme family
BSR23_RS19410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BSR23_RS19430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BSR23_RS19450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR23_RS19470	COG3706	GGDEF domain
BSR23_RS19490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BSR23_RS19520	COG3842	ATPase activity
BSR23_RS19585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSR23_RS19635	COG0583	DNA-binding transcription factor activity
BSR23_RS19645	COG4948	Mandelate Racemase Muconate Lactonizing
BSR23_RS19680	COG1342	Belongs to the UPF0251 family
BSR23_RS19690	COG3015	lipoprotein NlpE involved in copper resistance
BSR23_RS19700	COG3713	MltA-interacting MipA family protein
BSR23_RS19715	COG0583	DNA-binding transcription factor activity
BSR23_RS19745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BSR23_RS19755	COG1335	isochorismatase
BSR23_RS19765	COG0753	catalase activity
BSR23_RS19775	COG1349	DNA-binding transcription factor activity
BSR23_RS19780	COG0346	lactoylglutathione lyase activity
BSR23_RS19795	COG0583	DNA-binding transcription factor activity
BSR23_RS19805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR23_RS19810	COG2070	2-Nitropropane dioxygenase
BSR23_RS19815	COG0737	Belongs to the 5'-nucleotidase family
BSR23_RS19825	COG1309	transcriptional regulator
BSR23_RS19845	COG1280	lysine exporter protein (LysE YggA)
BSR23_RS19860	COG0459	protein refolding
BSR23_RS19870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BSR23_RS19895	COG1304	FMN binding
BSR23_RS19915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR23_RS19920	COG4786	Flagellar basal body rod
BSR23_RS19920	COG1256	bacterial-type flagellum assembly
BSR23_RS19930	COG1706	bacterial-type flagellum-dependent cell motility
BSR23_RS19935	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BSR23_RS19940	COG4786	Flagellar basal body rod
BSR23_RS19945	COG4787	bacterial-type flagellum-dependent cell motility
BSR23_RS19950	COG1749	Flagellar hook protein flgE
BSR23_RS19955	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BSR23_RS19960	COG1558	bacterial-type flagellum-dependent cell motility
BSR23_RS19965	COG1815	bacterial-type flagellum-dependent cell motility
BSR23_RS19985	COG0741	lytic transglycosylase activity
BSR23_RS19995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BSR23_RS20015	COG1760	l-serine dehydratase
BSR23_RS20020	COG3104	oligopeptide transport
BSR23_RS20040	COG0583	DNA-binding transcription factor activity
BSR23_RS20055	COG2866	Carboxypeptidase
BSR23_RS20060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSR23_RS20070	COG2990	Protein conserved in bacteria
BSR23_RS20095	COG3842	ATPase activity
BSR23_RS20105	COG1840	ABC-type Fe3 transport system, periplasmic component
BSR23_RS20110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BSR23_RS20115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BSR23_RS20120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BSR23_RS20125	COG1609	Transcriptional regulator
BSR23_RS20155	COG3240	lipase activity
BSR23_RS20165	COG0577	efflux transmembrane transporter activity
BSR23_RS20165	COG1136	(ABC) transporter
BSR23_RS20170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR23_RS20175	COG2067	long-chain fatty acid transport protein
BSR23_RS20185	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BSR23_RS20200	COG1011	Hydrolase
BSR23_RS20240	COG0110	maltose O-acetyltransferase activity
BSR23_RS20245	COG1765	OsmC-like protein
BSR23_RS20250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSR23_RS20250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSR23_RS20265	COG3046	protein related to deoxyribodipyrimidine photolyase
BSR23_RS20270	COG0415	Belongs to the DNA photolyase family
BSR23_RS20275	COG3706	GGDEF domain
BSR23_RS20290	COG0840	transmembrane signaling receptor activity
BSR23_RS20295	COG3706	GGDEF domain
BSR23_RS20310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BSR23_RS20330	COG3033	Beta-eliminating lyase
BSR23_RS20340	COG0579	oxidoreductase
BSR23_RS20370	COG2199	diguanylate cyclase activity
BSR23_RS20415	COG0583	DNA-binding transcription factor activity
BSR23_RS20425	COG0189	ligase activity
BSR23_RS20430	COG0189	ligase activity
BSR23_RS20430	COG4067	protein conserved in archaea
BSR23_RS20440	COG1166	arginine decarboxylase activity
BSR23_RS20445	COG0010	Belongs to the arginase family
BSR23_RS20450	COG2814	Major facilitator Superfamily
BSR23_RS20455	COG1770	oligopeptidase
BSR23_RS20470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BSR23_RS20475	COG1121	(ABC) transporter
BSR23_RS20480	COG0803	Belongs to the bacterial solute-binding protein 9 family
BSR23_RS20520	COG0848	biopolymer transport protein
BSR23_RS20525	COG0811	peptide transport
BSR23_RS20530	COG0811	peptide transport
BSR23_RS20550	COG0745	RESPONSE REGULATOR receiver
BSR23_RS20555	COG0039	L-malate dehydrogenase activity
BSR23_RS20560	COG0584	glycerophosphoryl diester phosphodiesterase
BSR23_RS20570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BSR23_RS20630	COG1901	pseudouridine methyltransferase
BSR23_RS20635	COG0312	modulator of DNA gyrase
BSR23_RS20640	COG0312	modulator of DNA gyrase
BSR23_RS20650	COG0351	phosphomethylpyrimidine kinase
BSR23_RS20655	COG1116	anion transmembrane transporter activity
BSR23_RS20660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSR23_RS20665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSR23_RS20670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BSR23_RS20675	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BSR23_RS20680	COG0352	thiamine-phosphate diphosphorylase activity
BSR23_RS20690	COG0243	molybdopterin cofactor binding
BSR23_RS20695	COG3005	denitrification pathway
BSR23_RS20705	COG1028	Short-chain dehydrogenase reductase Sdr
BSR23_RS20720	COG0456	acetyltransferase
BSR23_RS20720	COG0454	-acetyltransferase
BSR23_RS20740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR23_RS20745	COG1929	Belongs to the glycerate kinase type-1 family
BSR23_RS20750	COG2610	gluconate transmembrane transporter activity
BSR23_RS20755	COG3835	regulator
BSR23_RS20780	COG0546	phosphoglycolate phosphatase activity
BSR23_RS20795	COG0583	DNA-binding transcription factor activity
BSR23_RS20815	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BSR23_RS20820	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
BSR23_RS20820	COG3408	Glycogen debranching enzyme
BSR23_RS20850	COG3047	cAMP biosynthetic process
BSR23_RS20855	COG1357	PFAM Pentapeptide repeats (8 copies)
BSR23_RS20885	COG2375	cellular response to nickel ion
BSR23_RS20890	COG0823	Involved in the tonB-independent uptake of proteins
BSR23_RS20895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSR23_RS20915	COG0800	Aldolase
BSR23_RS20920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSR23_RS20935	COG1917	Cupin 2, conserved barrel domain protein
BSR23_RS20945	COG1028	Short-chain dehydrogenase reductase Sdr
BSR23_RS20950	COG1414	Transcriptional regulator
BSR23_RS20965	COG0583	DNA-binding transcription factor activity
BSR23_RS20970	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BSR23_RS20975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BSR23_RS21000	COG0561	phosphatase activity
BSR23_RS21005	COG0583	DNA-binding transcription factor activity
BSR23_RS21020	COG0564	pseudouridine synthase activity
BSR23_RS21025	COG0534	Mate efflux family protein
BSR23_RS21035	COG5001	Diguanylate cyclase
BSR23_RS21045	COG3123	guanosine phosphorylase activity
BSR23_RS21085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSR23_RS21095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BSR23_RS21100	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BSR23_RS21115	COG2259	Doxx family
BSR23_RS21120	COG1741	Belongs to the pirin family
BSR23_RS21140	COG0363	glucosamine-6-phosphate deaminase activity
BSR23_RS21155	COG0786	glutamate:sodium symporter activity
BSR23_RS21160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR23_RS21165	COG1131	(ABC) transporter
BSR23_RS21175	COG0786	glutamate:sodium symporter activity
BSR23_RS21210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BSR23_RS21220	COG3279	Response regulator of the LytR AlgR family
BSR23_RS21225	COG3275	phosphorelay sensor kinase activity
BSR23_RS21260	COG0772	Belongs to the SEDS family
BSR23_RS21265	COG0217	transcriptional regulatory protein
BSR23_RS21290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BSR23_RS21290	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
BSR23_RS21300	COG0444	Belongs to the ABC transporter superfamily
BSR23_RS21305	COG4608	Belongs to the ABC transporter superfamily
BSR23_RS21330	COG1444	tRNA N-acetyltransferase activity
BSR23_RS21350	COG3340	Belongs to the peptidase S51 family
BSR23_RS21355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BSR23_RS21360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR23_RS21360	COG1263	PTS System
BSR23_RS21365	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BSR23_RS21385	COG4166	transmembrane transport
BSR23_RS21430	COG0259	pyridoxamine-phosphate oxidase activity
BSR23_RS21460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSR23_RS21505	COG1132	(ABC) transporter
BSR23_RS21515	COG2207	Transcriptional regulator
BSR23_RS21535	COG0513	Belongs to the DEAD box helicase family
BSR23_RS21540	COG2258	MOSC domain
BSR23_RS21555	COG1486	melibiose metabolic process
BSR23_RS21560	COG0583	DNA-binding transcription factor activity
BSR23_RS21580	COG1595	DNA-templated transcription, initiation
BSR23_RS21615	COG3634	alkyl hydroperoxide reductase activity
BSR23_RS21625	COG1846	Transcriptional regulator
BSR23_RS21630	COG1764	response to oxidative stress
BSR23_RS21650	COG0463	Glycosyl transferase, family 2
BSR23_RS21670	COG0826	peptidase U32
BSR23_RS21700	COG1653	transport
BSR23_RS21705	COG0019	diaminopimelate decarboxylase activity
BSR23_RS21710	COG4264	IucA IucC family
BSR23_RS21735	COG4772	TonB-dependent receptor
BSR23_RS21740	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BSR23_RS21745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR23_RS21750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR23_RS21755	COG1120	ATPase activity
BSR23_RS21760	COG0840	transmembrane signaling receptor activity
BSR23_RS21765	COG0612	Peptidase, M16
BSR23_RS21775	COG0739	heme binding
BSR23_RS21785	COG2814	Major facilitator Superfamily
BSR23_RS21800	COG4580	involved in the transport of maltose and maltodextrins
BSR23_RS21825	COG2356	endonuclease I
BSR23_RS21845	COG1982	Orn Lys Arg decarboxylase major
BSR23_RS21850	COG0531	amino acid
BSR23_RS21860	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BSR23_RS21870	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BSR23_RS21875	COG1162	GTPase activity
BSR23_RS21880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR23_RS21880	COG1263	PTS System
BSR23_RS21890	COG1999	signal sequence binding
BSR23_RS21905	COG2909	trisaccharide binding
BSR23_RS21920	COG0058	SHG alpha-glucan phosphorylase activity
BSR23_RS21925	COG1640	4-alpha-glucanotransferase
BSR23_RS21930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BSR23_RS21935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSR23_RS21940	COG0366	Alpha amylase catalytic
BSR23_RS21955	COG3366	ferrous iron transmembrane transporter activity
BSR23_RS21960	COG0700	Nucleoside recognition
BSR23_RS21965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSR23_RS21970	COG3339	Conserved Protein
BSR23_RS21975	COG1301	dicarboxylic acid transport
BSR23_RS21985	COG0583	DNA-binding transcription factor activity
BSR23_RS22000	COG0489	protein tyrosine kinase activity
BSR23_RS22000	COG3206	protein involved in exopolysaccharide biosynthesis
BSR23_RS22020	COG2095	MarC family integral membrane protein
BSR23_RS22025	COG4667	esterase of the alpha-beta hydrolase superfamily
BSR23_RS22030	COG3397	chitin binding
BSR23_RS22035	COG1054	Belongs to the UPF0176 family
BSR23_RS22050	COG1686	Belongs to the peptidase S11 family
BSR23_RS22075	COG0583	DNA-binding transcription factor activity
BSR23_RS22080	COG4628	conserved protein (DUF2132)
BSR23_RS22090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BSR23_RS22100	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
BSR23_RS22105	COG0628	permease
BSR23_RS22150	COG2814	Major facilitator Superfamily
BSR23_RS22165	COG0454	-acetyltransferase
BSR23_RS22175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BSR23_RS22180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BSR23_RS22185	COG1882	Formate acetyltransferase
BSR23_RS22235	COG1360	Flagellar Motor Protein
BSR23_RS22240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BSR23_RS22245	COG1191	sigma factor activity
BSR23_RS22250	COG1580	Controls the rotational direction of flagella during chemotaxis
BSR23_RS22265	COG1516	flagellar protein fliS
BSR23_RS22270	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BSR23_RS22280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR23_RS22295	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BSR23_RS22305	COG1987	bacterial-type flagellum assembly
BSR23_RS22385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BSR23_RS22405	COG0346	lactoylglutathione lyase activity
BSR23_RS22440	COG0745	RESPONSE REGULATOR receiver
BSR23_RS22460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR23_RS22470	COG0156	8-amino-7-oxononanoate synthase activity
BSR23_RS22475	COG1063	alcohol dehydrogenase
BSR23_RS22515	COG0668	transmembrane transport
BSR23_RS22525	COG1304	FMN binding
BSR23_RS22530	COG1620	l-lactate permease
BSR23_RS22535	COG0583	DNA-binding transcription factor activity
BSR23_RS22540	COG1505	serine-type exopeptidase activity
BSR23_RS22545	COG4172	Belongs to the ABC transporter superfamily
BSR23_RS22555	COG1067	ATP-dependent peptidase activity
BSR23_RS22585	COG1247	-acetyltransferase
BSR23_RS22590	COG0437	4 iron, 4 sulfur cluster binding
BSR23_RS22595	COG0348	domain, Protein
BSR23_RS22610	COG1122	ATPase activity
BSR23_RS22615	COG4720	Psort location CytoplasmicMembrane, score
BSR23_RS22620	COG1566	PFAM secretion protein HlyD family protein
BSR23_RS22630	COG3706	GGDEF domain
BSR23_RS22645	COG0813	purine-nucleoside phosphorylase activity
BSR23_RS22655	COG3272	Protein of unknown function (DUF1722)
BSR23_RS22660	COG0789	Transcriptional regulator
BSR23_RS22665	COG0415	Belongs to the DNA photolyase family
BSR23_RS22670	COG1376	ErfK ybiS ycfS ynhG family protein
BSR23_RS22670	COG1388	LysM domain
BSR23_RS22680	COG0513	Belongs to the DEAD box helicase family
BSR23_RS22685	COG1770	oligopeptidase
BSR23_RS22690	COG4771	TonB-dependent receptor
BSR23_RS22720	COG0573	inorganic phosphate transmembrane transporter activity
BSR23_RS22725	COG0581	inorganic phosphate transmembrane transporter activity
BSR23_RS22730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSR23_RS22745	COG2304	oxidoreductase activity
BSR23_RS22765	COG0714	Associated with various cellular activities
BSR23_RS22775	COG0840	transmembrane signaling receptor activity
BSR23_RS22785	COG2197	response regulator
BSR23_RS22835	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BSR23_RS22840	COG1120	ATPase activity
BSR23_RS22845	COG4774	siderophore transport
BSR23_RS22850	COG1132	(ABC) transporter
BSR23_RS22855	COG2205	protein histidine kinase activity
BSR23_RS22865	COG0569	domain protein
BSR23_RS22870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BSR23_RS22880	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BSR23_RS22885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BSR23_RS22900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR23_RS22900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR23_RS22900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR23_RS22905	COG2207	Transcriptional regulator
BSR23_RS22915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR23_RS22920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR23_RS22925	COG2084	Dehydrogenase
BSR23_RS22930	COG0753	catalase activity
BSR23_RS22940	COG2130	NADP-dependent
BSR23_RS22945	COG1309	transcriptional regulator
BSR23_RS22950	COG3097	Belongs to the UPF0267 family
BSR23_RS22980	COG0438	transferase activity, transferring glycosyl groups
BSR23_RS23010	COG3842	ATPase activity
BSR23_RS23020	COG1175	transmembrane transport
BSR23_RS23025	COG3833	ABC-type maltose transport systems, permease component
BSR23_RS23045	COG3746	phosphate-selective porin O and P
BSR23_RS23065	COG1028	Short-chain dehydrogenase reductase Sdr
BSR23_RS23090	COG2801	Transposase and inactivated derivatives
BSR23_RS23095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BSR23_RS23105	COG0625	glutathione transferase activity
BSR23_RS23120	COG1686	Belongs to the peptidase S11 family
BSR23_RS23140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BSR23_RS23160	COG1278	Cold shock
BSR23_RS23165	COG1741	Belongs to the pirin family
BSR23_RS23170	COG4667	esterase of the alpha-beta hydrolase superfamily
BSR23_RS23195	COG2814	Major facilitator Superfamily
BSR23_RS23205	COG0673	inositol 2-dehydrogenase activity
BSR23_RS23210	COG2194	sulfuric ester hydrolase activity
BSR23_RS23215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BSR23_RS23225	COG2205	protein histidine kinase activity
BSR23_RS23230	COG0745	RESPONSE REGULATOR receiver
BSR23_RS23235	COG4221	oxidoreductase activity
BSR23_RS23255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BSR23_RS23275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BSR23_RS23285	COG2814	Major facilitator Superfamily
BSR23_RS23300	COG1418	mRNA catabolic process
BSR23_RS23310	COG0402	S-adenosylhomocysteine deaminase activity
BSR23_RS23315	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BSR23_RS23325	COG2239	Acts as a magnesium transporter
BSR23_RS23330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BSR23_RS23345	COG0531	amino acid
BSR23_RS23355	COG1522	sequence-specific DNA binding
BSR23_RS23380	COG2205	protein histidine kinase activity
BSR23_RS23380	COG5002	protein histidine kinase activity
BSR23_RS23380	COG0784	Response regulator, receiver
BSR23_RS23385	COG0673	inositol 2-dehydrogenase activity
BSR23_RS23390	COG0534	Mate efflux family protein
BSR23_RS23395	COG2926	Belongs to the UPF0265 family
BSR23_RS23410	COG3132	Protein of unknown function, DUF480
BSR23_RS23415	COG2827	Endonuclease containing a URI domain
BSR23_RS23420	COG1879	ABC-type sugar transport system periplasmic component
BSR23_RS23425	COG0784	Response regulator, receiver
BSR23_RS23425	COG2205	protein histidine kinase activity
BSR23_RS23435	COG1566	PFAM secretion protein HlyD family protein
BSR23_RS23455	COG1522	sequence-specific DNA binding
BSR23_RS23485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSR23_RS23490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSR23_RS23500	COG1280	lysine exporter protein (LysE YggA)
BSR23_RS23510	COG0183	Belongs to the thiolase family
BSR23_RS23530	COG3005	denitrification pathway
BSR23_RS23540	COG0243	molybdopterin cofactor binding
BSR23_RS23550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BSR23_RS23555	COG3850	Histidine kinase
BSR23_RS23560	COG2197	response regulator
BSR23_RS23575	COG2195	Cleaves the N-terminal amino acid of tripeptides
BSR23_RS23595	COG0840	transmembrane signaling receptor activity
BSR23_RS23605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BSR23_RS23620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BSR23_RS23625	COG2814	Major facilitator Superfamily
BSR23_RS23635	COG0840	transmembrane signaling receptor activity
BSR23_RS23640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BSR23_RS23645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BSR23_RS23675	COG2897	thiosulfate sulfurtransferase activity
BSR23_RS23695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSR23_RS23705	COG0302	gtp cyclohydrolase
BSR23_RS23710	COG1914	H( )-stimulated, divalent metal cation uptake system
BSR23_RS23720	COG0038	chloride channel
BSR23_RS23735	COG4989	oxidoreductase activity
BSR23_RS23750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BSR23_RS23750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BSR23_RS23755	COG0516	GMP reductase activity
BSR23_RS23760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSR23_RS23830	COG3474	cytochrome
BSR23_RS23840	COG0789	Transcriptional regulator
BSR23_RS23845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BSR23_RS23850	COG0384	phenazine biosynthesis protein PhzF
BSR23_RS23860	COG1294	oxidase, subunit
BSR23_RS23865	COG1271	oxidase subunit
BSR23_RS23870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR23_RS23875	COG0110	maltose O-acetyltransferase activity
BSR23_RS23885	COG3264	Mechanosensitive ion channel
BSR23_RS23885	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BSR23_RS23900	COG3437	response regulator, receiver
BSR23_RS23900	COG4999	Histidine kinase
BSR23_RS23900	COG2205	protein histidine kinase activity
BSR23_RS23900	COG3850	Histidine kinase
BSR23_RS23910	COG4770	biotin carboxylase activity
BSR23_RS23920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BSR23_RS23925	COG1960	acyl-CoA dehydrogenase activity
BSR23_RS23935	COG0183	Belongs to the thiolase family
BSR23_RS23945	COG1960	acyl-CoA dehydrogenase activity
BSR23_RS23950	COG1024	Enoyl-CoA hydratase
BSR23_RS23965	COG1028	Short-chain dehydrogenase reductase Sdr
BSR23_RS23975	COG3706	GGDEF domain
BSR23_RS23980	COG1309	transcriptional regulator
BSR23_RS23985	COG1012	belongs to the aldehyde dehydrogenase family
BSR23_RS24000	COG4176	ABC-type proline glycine betaine transport system permease component
BSR23_RS24005	COG4175	Glycine betaine
BSR23_RS24005	COG0517	IMP dehydrogenase activity
BSR23_RS24020	COG0330	HflC and HflK could
BSR23_RS24030	COG3300	MHYT domain
BSR23_RS24030	COG5001	Diguanylate cyclase
BSR23_RS24050	COG2205	protein histidine kinase activity
BSR23_RS24050	COG0784	Response regulator, receiver
BSR23_RS24110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BSR23_RS24115	COG5001	Diguanylate cyclase
BSR23_RS24120	COG1869	D-ribose catabolic process
BSR23_RS24125	COG1129	ABC transporter
BSR23_RS24130	COG1172	Belongs to the binding-protein-dependent transport system permease family
BSR23_RS24135	COG1879	ABC-type sugar transport system periplasmic component
BSR23_RS24140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSR23_RS24145	COG1609	Transcriptional regulator
BSR23_RS24160	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BSR23_RS24180	COG0745	RESPONSE REGULATOR receiver
BSR23_RS24195	COG1785	Belongs to the alkaline phosphatase family
BSR23_RS24225	COG0814	amino acid
BSR23_RS24235	COG0243	molybdopterin cofactor binding
BSR23_RS24240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BSR23_RS24240	COG1648	precorrin-2 dehydrogenase activity
BSR23_RS24260	COG3707	response regulator
BSR23_RS24270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSR23_RS24275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSR23_RS24280	COG1116	anion transmembrane transporter activity
BSR23_RS24285	COG2146	nitrite reductase [NAD(P)H] activity
BSR23_RS24285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BSR23_RS24380	COG0631	protein serine/threonine phosphatase activity
BSR23_RS24450	COG0420	3'-5' exonuclease activity
BSR23_RS24455	COG0419	ATPase involved in DNA repair
BSR23_RS24475	COG3040	lipid binding
BSR23_RS24485	COG2814	Major facilitator Superfamily
BSR23_RS24495	COG1288	antiporter activity
BSR23_RS24510	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BSR23_RS24525	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BSR23_RS24545	COG0583	DNA-binding transcription factor activity
BSR23_RS24550	COG0277	FAD linked oxidase domain protein
BSR23_RS24570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BSR23_RS24660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BSR23_RS24665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BSR23_RS24675	COG2116	formate transmembrane transporter activity
BSR23_RS24695	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BSR23_RS24730	COG0534	Mate efflux family protein
BSR23_RS24735	COG0745	RESPONSE REGULATOR receiver
BSR23_RS24735	COG2205	protein histidine kinase activity
BSR23_RS24735	COG3292	Two component regulator propeller
BSR23_RS24745	COG3118	belongs to the thioredoxin family
BSR23_RS24750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BSR23_RS24775	COG2271	Major facilitator Superfamily
BSR23_RS24780	COG3851	Histidine kinase
BSR23_RS24785	COG2197	response regulator
BSR23_RS24795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BSR23_RS24800	COG0583	DNA-binding transcription factor activity
BSR23_RS24810	COG0243	molybdopterin cofactor binding
BSR23_RS24840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSR23_RS24855	COG1328	CTP reductase activity
BSR23_RS24860	COG0602	queuosine metabolic process
BSR23_RS24865	COG0534	Mate efflux family protein
BSR23_RS24885	COG4067	protein conserved in archaea
BSR23_RS24885	COG0189	ligase activity
BSR23_RS24895	COG3111	PFAM Bacterial OB fold (BOF) protein
BSR23_RS24900	COG1492	cobalamin metabolic process
BSR23_RS24905	COG0725	ABC transporter, periplasmic molybdate-binding protein
BSR23_RS24910	COG4149	molybdate abc transporter
BSR23_RS24915	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BSR23_RS24925	COG3706	GGDEF domain
BSR23_RS24925	COG4251	negative regulation of phosphorylation
BSR23_RS24925	COG2203	Gaf domain
BSR23_RS24925	COG5001	Diguanylate cyclase
BSR23_RS24950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BSR23_RS24955	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BSR23_RS24980	COG3140	Belongs to the UPF0181 family
BSR23_RS24985	COG0589	response to stress
BSR23_RS25015	COG0023	Translation Initiation Factor
BSR23_RS25025	COG1181	Belongs to the D-alanine--D-alanine ligase family
BSR23_RS25035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR23_RS25035	COG1042	CoA-binding domain protein
BSR23_RS25035	COG0045	succinate-CoA ligase (ADP-forming) activity
BSR23_RS25040	COG0583	DNA-binding transcription factor activity
BSR23_RS25045	COG1629	transport
BSR23_RS25045	COG4771	TonB-dependent receptor
BSR23_RS25055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BSR23_RS25060	COG3447	MASE1 domain protein
BSR23_RS25060	COG5001	Diguanylate cyclase
BSR23_RS25060	COG5002	protein histidine kinase activity
BSR23_RS25065	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BSR23_RS25070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BSR23_RS25075	COG1984	allophanate hydrolase subunit 2
BSR23_RS25085	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BSR23_RS25090	COG4181	ATPase activity
BSR23_RS25100	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BSR23_RS25105	COG3300	MHYT domain
BSR23_RS25105	COG5001	Diguanylate cyclase
BSR23_RS25115	COG0484	heat shock protein binding
BSR23_RS25140	COG4533	DNA binding
BSR23_RS25150	COG2050	protein possibly involved in aromatic compounds catabolism
BSR23_RS25165	COG2067	long-chain fatty acid transport protein
BSR23_RS25170	COG2267	carboxylic ester hydrolase activity
BSR23_RS25185	COG0861	Integral membrane protein TerC family
BSR23_RS25190	COG0737	Belongs to the 5'-nucleotidase family
BSR23_RS25195	COG3593	DNA synthesis involved in DNA repair
BSR23_RS25205	COG0583	DNA-binding transcription factor activity
BSR23_RS25215	COG2116	formate transmembrane transporter activity
BSR23_RS25220	COG2353	YceI-like domain
BSR23_RS25225	COG3038	cytochrome b561
BSR23_RS25240	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BSR23_RS25245	COG0513	Belongs to the DEAD box helicase family
BSR23_RS25250	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
BSR23_RS25260	COG0840	transmembrane signaling receptor activity
BSR23_RS25270	COG0546	phosphoglycolate phosphatase activity
BSR23_RS25280	COG3437	response regulator, receiver
BSR23_RS25280	COG0784	Response regulator, receiver
BSR23_RS25300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSR23_RS25305	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BSR23_RS25310	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BSR23_RS25325	COG2207	Transcriptional regulator
BSR23_RS25330	COG1979	alcohol dehydrogenase
BSR23_RS25355	COG2271	Major facilitator Superfamily
BSR23_RS25360	COG0469	pyruvate kinase activity
BSR23_RS25365	COG1126	abc transporter atp-binding protein
BSR23_RS25370	COG0765	amino acid transport
BSR23_RS25375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR23_RS25380	COG0765	amino acid transport
BSR23_RS25385	COG2200	EAL domain
BSR23_RS25385	COG2203	Gaf domain
BSR23_RS25385	COG2199	diguanylate cyclase activity
BSR23_RS25405	COG1609	Transcriptional regulator
BSR23_RS25410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR23_RS25410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR23_RS25415	COG1105	Belongs to the carbohydrate kinase PfkB family
BSR23_RS25420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR23_RS25420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR23_RS25420	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BSR23_RS25460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BSR23_RS25465	COG0509	glycine decarboxylation via glycine cleavage system
BSR23_RS25470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BSR23_RS25470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BSR23_RS25475	COG0494	nUDIX hydrolase
BSR23_RS25505	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BSR23_RS25510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BSR23_RS25515	COG0583	DNA-binding transcription factor activity
BSR23_RS25520	COG2176	DNA-directed DNA polymerase activity
BSR23_RS25550	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
BSR23_RS25570	COG0242	peptide deformylase activity
BSR23_RS25600	COG2239	Acts as a magnesium transporter
BSR23_RS25620	COG0346	lactoylglutathione lyase activity
BSR23_RS25625	COG1902	pentaerythritol trinitrate reductase activity
BSR23_RS25645	COG5642	Protein of unknown function (DUF2384)
BSR23_RS25650	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BSR23_RS25670	COG4565	transcriptional regulatory protein
BSR23_RS25675	COG3290	protein histidine kinase activity
BSR23_RS25680	COG0471	metal ion transport
BSR23_RS25710	COG2076	Multidrug Resistance protein
BSR23_RS25725	COG0671	phosphoesterase, PA-phosphatase related
BSR23_RS25740	COG2962	Rard protein
BSR23_RS25760	COG0835	chemotaxis
BSR23_RS25760	COG0784	Response regulator, receiver
BSR23_RS25785	COG2197	response regulator
BSR23_RS25795	COG3706	GGDEF domain
BSR23_RS25800	COG2197	response regulator
BSR23_RS25805	COG5001	Diguanylate cyclase
BSR23_RS25805	COG3300	MHYT domain
BSR23_RS25825	COG0583	DNA-binding transcription factor activity
BSR23_RS25900	COG4964	Belongs to the GSP D family
BSR23_RS25955	COG0582	viral genome integration into host DNA
BSR23_RS25995	COG0514	ATP-dependent DNA helicase (RecQ)
BSR23_RS26010	COG0737	Belongs to the 5'-nucleotidase family
BSR23_RS26025	COG0477	Major facilitator Superfamily
BSR23_RS26025	COG2814	Major facilitator Superfamily
BSR23_RS26030	COG0457	Tetratricopeptide repeat
BSR23_RS26085	COG2801	Transposase and inactivated derivatives
BSR23_RS26160	COG2200	EAL domain
BSR23_RS26165	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BSR23_RS26200	COG1484	DNA-dependent DNA replication
BSR23_RS26375	COG1192	Involved in chromosome partitioning
BSR23_RS26400	COG0419	ATPase involved in DNA repair
BSR23_RS26670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BSR23_RS26705	COG3504	Conjugal transfer protein
BSR23_RS26720	COG4962	Type ii secretion system protein e
BSR23_RS26730	COG3451	type IV secretory pathway VirB4
BSR23_RS26735	COG5268	conjugation