locus-tag	class	description
HK81_RS00055	COG0646	methionine synthase
HK81_RS00055	COG1410	methionine synthase
HK81_RS00380	COG0525	valine-tRNA ligase activity
HK81_RS00390	COG0525	valine-tRNA ligase activity
HK81_RS00405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HK81_RS00655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HK81_RS00660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HK81_RS00710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HK81_RS00845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HK81_RS00890	COG0585	pseudouridine synthase activity
HK81_RS00900	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HK81_RS00920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HK81_RS00970	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HK81_RS01050	COG1459	type II secretion system
HK81_RS01140	COG0617	tRNA 3'-terminal CCA addition
HK81_RS01345	COG0628	permease
HK81_RS01475	COG1185	polyribonucleotide nucleotidyltransferase activity
HK81_RS01535	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HK81_RS01580	COG1022	Amp-dependent synthetase and ligase
HK81_RS01745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HK81_RS01785	COG2171	N-acyltransferase activity
HK81_RS01825	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HK81_RS01840	COG1074	ATP-dependent DNA helicase activity
HK81_RS01850	COG1074	ATP-dependent DNA helicase activity
HK81_RS01965	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HK81_RS02380	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HK81_RS02510	COG1250	3-hydroxyacyl-CoA dehydrogenase
HK81_RS02510	COG1024	Enoyl-CoA hydratase
HK81_RS02705	COG1785	Belongs to the alkaline phosphatase family
HK81_RS03005	COG3706	GGDEF domain
HK81_RS03025	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HK81_RS03090	COG0564	pseudouridine synthase activity
HK81_RS03205	COG0587	DNA-directed DNA polymerase activity
HK81_RS03250	COG0539	negative regulation of cytoplasmic translation
HK81_RS03275	COG0284	orotidine-5'-phosphate decarboxylase activity
HK81_RS03305	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HK81_RS03545	COG0318	PFAM AMP-dependent synthetase and ligase
HK81_RS03750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HK81_RS03900	COG0017	Asparaginyl-tRNA synthetase
HK81_RS03935	COG0557	exoribonuclease II activity
HK81_RS04490	COG1012	belongs to the aldehyde dehydrogenase family
HK81_RS04575	COG2205	protein histidine kinase activity
HK81_RS04575	COG3437	response regulator, receiver
HK81_RS04575	COG4999	Histidine kinase
HK81_RS04575	COG3850	Histidine kinase
HK81_RS04625	COG0531	amino acid
HK81_RS05355	COG2902	Dehydrogenase
HK81_RS05470	COG2010	Cytochrome c
HK81_RS05645	COG0243	molybdopterin cofactor binding
HK81_RS05645	COG3383	formate dehydrogenase (NAD+) activity
HK81_RS05860	COG0243	molybdopterin cofactor binding
HK81_RS06815	COG0471	metal ion transport
HK81_RS07275	COG0243	molybdopterin cofactor binding
HK81_RS07555	COG1674	ftsk spoiiie
HK81_RS07560	COG1674	ftsk spoiiie
HK81_RS07845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HK81_RS07955	COG1410	methionine synthase
HK81_RS07955	COG0646	methionine synthase
HK81_RS07960	COG0527	aspartate kinase activity
HK81_RS07970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HK81_RS07980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HK81_RS07995	COG0629	single-stranded DNA binding
HK81_RS08000	COG2200	EAL domain
HK81_RS08000	COG2199	diguanylate cyclase activity
HK81_RS08025	COG3267	Type II secretory pathway component ExeA
HK81_RS08025	COG3409	Peptidoglycan-binding domain 1 protein
HK81_RS08035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HK81_RS08040	COG1459	type II secretion system
HK81_RS08085	COG1077	Cell shape determining protein MreB Mrl
HK81_RS08090	COG1792	Involved in formation and maintenance of cell shape
HK81_RS08095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HK81_RS08100	COG0424	maF-like protein
HK81_RS08110	COG3164	Protein of unknown function
HK81_RS08115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HK81_RS08120	COG0312	modulator of DNA gyrase
HK81_RS08125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HK81_RS08130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HK81_RS08140	COG0564	pseudouridine synthase activity
HK81_RS08145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HK81_RS08150	COG3028	Belongs to the UPF0307 family
HK81_RS08155	COG0312	modulator of DNA gyrase
HK81_RS08160	COG2239	Acts as a magnesium transporter
HK81_RS08165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK81_RS08170	COG1660	Displays ATPase and GTPase activities
HK81_RS08175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK81_RS08180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HK81_RS08190	COG1137	ATPase activity
HK81_RS08195	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HK81_RS08205	COG0517	IMP dehydrogenase activity
HK81_RS08205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HK81_RS08215	COG1127	ABC transporter
HK81_RS08220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HK81_RS08225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HK81_RS08230	COG2854	intermembrane phospholipid transfer
HK81_RS08240	COG5007	Belongs to the BolA IbaG family
HK81_RS08245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HK81_RS08250	COG0204	Acyl-transferase
HK81_RS08255	COG0251	oxidation-reduction process
HK81_RS08260	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HK81_RS08265	COG0540	Belongs to the ATCase OTCase family
HK81_RS08270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HK81_RS08275	COG2235	arginine
HK81_RS08300	COG0525	valine-tRNA ligase activity
HK81_RS08305	COG2927	DNA polymerase III (CHI subunit)
HK81_RS08310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HK81_RS08315	COG0795	lipopolysaccharide-transporting ATPase activity
HK81_RS08320	COG0795	lipopolysaccharide-transporting ATPase activity
HK81_RS08335	COG1028	Short-chain dehydrogenase reductase Sdr
HK81_RS08360	COG0726	polysaccharide deacetylase
HK81_RS08365	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HK81_RS08370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HK81_RS08375	COG1447	Phosphotransferase system cellobiose-specific component IIA
HK81_RS08380	COG1486	melibiose metabolic process
HK81_RS08385	COG3394	polysaccharide catabolic process
HK81_RS08395	COG3437	response regulator, receiver
HK81_RS08470	COG0840	transmembrane signaling receptor activity
HK81_RS08510	COG0741	lytic transglycosylase activity
HK81_RS08515	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HK81_RS08525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HK81_RS08535	COG2066	Belongs to the glutaminase family
HK81_RS08540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HK81_RS08545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HK81_RS08555	COG1872	DUF167
HK81_RS08560	COG0762	integral membrane protein
HK81_RS08565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HK81_RS08570	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HK81_RS08585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HK81_RS08590	COG1678	Uncharacterized ACR, COG1678
HK81_RS08595	COG0189	ligase activity
HK81_RS08600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HK81_RS08605	COG2356	endonuclease I
HK81_RS08610	COG3091	SprT-like family
HK81_RS08620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HK81_RS08630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HK81_RS08635	COG0583	DNA-binding transcription factor activity
HK81_RS08640	COG4771	TonB-dependent receptor
HK81_RS08645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HK81_RS08650	COG0126	phosphoglycerate kinase activity
HK81_RS08655	COG0191	fructose-bisphosphate aldolase activity
HK81_RS08660	COG0668	transmembrane transport
HK81_RS08665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HK81_RS08675	COG0583	DNA-binding transcription factor activity
HK81_RS08685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HK81_RS08690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HK81_RS08695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HK81_RS08700	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HK81_RS08705	COG3079	Belongs to the UPF0149 family
HK81_RS08710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HK81_RS08715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HK81_RS08730	COG0354	folic acid binding
HK81_RS08735	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HK81_RS08740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HK81_RS08745	COG1595	DNA-templated transcription, initiation
HK81_RS08750	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HK81_RS08760	COG3086	response to oxidative stress
HK81_RS08765	COG0481	GTPase activity
HK81_RS08775	COG0571	ribonuclease III activity
HK81_RS08780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HK81_RS08785	COG1381	Involved in DNA repair and RecF pathway recombination
HK81_RS08790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HK81_RS08795	COG0736	holo-[acyl-carrier-protein] synthase activity
HK81_RS08805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HK81_RS08810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HK81_RS08815	COG3956	TIGRFAM MazG family protein
HK81_RS08820	COG0504	CTP synthase activity
HK81_RS08825	COG0148	phosphopyruvate hydratase activity
HK81_RS08830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HK81_RS08835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HK81_RS08840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HK81_RS08845	COG0585	pseudouridine synthase activity
HK81_RS08850	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HK81_RS08855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HK81_RS08870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HK81_RS08875	COG1546	Belongs to the CinA family
HK81_RS08880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HK81_RS08885	COG2137	regulation of response to DNA damage stimulus
HK81_RS08890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HK81_RS08895	COG0527	aspartate kinase activity
HK81_RS08955	COG3630	sodium ion export across plasma membrane
HK81_RS08960	COG5016	pyruvate
HK81_RS08960	COG0511	ligase activity, forming carbon-carbon bonds
HK81_RS08965	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HK81_RS08975	COG1238	metal cluster binding
HK81_RS08980	COG0612	Peptidase, M16
HK81_RS08985	COG2918	glutathione biosynthetic process
HK81_RS08995	COG1854	S-ribosylhomocysteine lyase activity
HK81_RS09000	COG4536	flavin adenine dinucleotide binding
HK81_RS09005	COG4137	Cytochrome C assembly protein
HK81_RS09010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HK81_RS09015	COG0228	four-way junction DNA binding
HK81_RS09020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HK81_RS09025	COG0336	Belongs to the RNA methyltransferase TrmD family
HK81_RS09030	COG0335	large ribosomal subunit rRNA binding
HK81_RS09035	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HK81_RS09040	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HK81_RS09045	COG0237	dephospho-CoA kinase activity
HK81_RS09055	COG1459	type II secretion system
HK81_RS09060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HK81_RS09070	COG0157	Belongs to the NadC ModD family
HK81_RS09080	COG2186	Transcriptional regulator
HK81_RS09085	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HK81_RS09090	COG0508	dehydrogenase complex catalyzes the overall conversion of
HK81_RS09095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HK81_RS09110	COG0288	reversible hydration of carbon dioxide
HK81_RS09115	COG0659	secondary active sulfate transmembrane transporter activity
HK81_RS09120	COG1131	(ABC) transporter
HK81_RS09125	COG0842	Transport permease protein
HK81_RS09130	COG1560	Kdo2-lipid A biosynthetic process
HK81_RS09135	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HK81_RS09140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HK81_RS09145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HK81_RS09155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HK81_RS09165	COG1489	DNA binding
HK81_RS09170	COG1643	Atp-dependent helicase
HK81_RS09175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HK81_RS09180	COG1752	Esterase of the alpha-beta hydrolase superfamily
HK81_RS09185	COG1049	propionate catabolic process, 2-methylcitrate cycle
HK81_RS09190	COG3112	Uncharacterised protein family (UPF0231)
HK81_RS09200	COG0004	ammonium transporteR
HK81_RS09205	COG1840	ABC-type Fe3 transport system, periplasmic component
HK81_RS09215	COG3842	ATPase activity
HK81_RS09220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HK81_RS09235	COG2971	BadF BadG BcrA BcrD
HK81_RS09245	COG4608	Belongs to the ABC transporter superfamily
HK81_RS09250	COG0444	Belongs to the ABC transporter superfamily
HK81_RS09255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HK81_RS09265	COG0747	negative chemotaxis
HK81_RS09270	COG0784	Response regulator, receiver
HK81_RS09270	COG2198	Histidine kinase
HK81_RS09270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HK81_RS09270	COG2205	protein histidine kinase activity
HK81_RS09275	COG2813	Specifically methylates the guanine in position
HK81_RS09280	COG0628	permease
HK81_RS09285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HK81_RS09290	COG0316	Belongs to the HesB IscA family
HK81_RS09300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HK81_RS09305	COG0739	heme binding
HK81_RS09310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HK81_RS09320	COG2027	D-alanyl-D-alanine carboxypeptidase
HK81_RS09325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HK81_RS09330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HK81_RS09335	COG1534	Rna-binding protein
HK81_RS09340	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HK81_RS09345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HK81_RS09350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HK81_RS09355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HK81_RS09365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HK81_RS09380	COG0779	Required for maturation of 30S ribosomal subunits
HK81_RS09385	COG0195	Participates in both transcription termination and antitermination
HK81_RS09390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HK81_RS09395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HK81_RS09400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HK81_RS09405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HK81_RS09410	COG1185	polyribonucleotide nucleotidyltransferase activity
HK81_RS09425	COG0534	Mate efflux family protein
HK81_RS09430	COG0826	peptidase U32
HK81_RS09435	COG0826	peptidase U32
HK81_RS09445	COG3154	lipid carrier protein
HK81_RS09450	COG3153	acetyltransferase
HK81_RS09470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HK81_RS09480	COG0084	hydrolase, TatD family'
HK81_RS09485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HK81_RS09490	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HK81_RS09495	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HK81_RS09500	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HK81_RS09505	COG0813	purine-nucleoside phosphorylase activity
HK81_RS09515	COG0560	Phosphoserine phosphatase
HK81_RS09525	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HK81_RS09530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HK81_RS09535	COG0583	DNA-binding transcription factor activity
HK81_RS09545	COG1022	Amp-dependent synthetase and ligase
HK81_RS09550	COG2169	Transcriptional regulator
HK81_RS09575	COG4964	Belongs to the GSP D family
HK81_RS09635	COG0583	DNA-binding transcription factor activity
HK81_RS09640	COG0531	amino acid
HK81_RS09645	COG2731	YhcH YjgK YiaL family protein
HK81_RS09650	COG3250	beta-galactosidase activity
HK81_RS09655	COG1609	Transcriptional regulator
HK81_RS09660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HK81_RS09670	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HK81_RS09675	COG2017	converts alpha-aldose to the beta-anomer
HK81_RS09690	COG2211	Major facilitator Superfamily
HK81_RS09695	COG1609	Transcriptional regulator
HK81_RS09700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK81_RS09715	COG0598	Magnesium transport protein CorA
HK81_RS09720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HK81_RS09725	COG1349	DNA-binding transcription factor activity
HK81_RS09730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HK81_RS09735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HK81_RS09740	COG2271	Major facilitator Superfamily
HK81_RS09745	COG0584	glycerophosphoryl diester phosphodiesterase
HK81_RS09750	COG2171	N-acyltransferase activity
HK81_RS09755	COG3141	response to X-ray
HK81_RS09775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HK81_RS09785	COG1074	ATP-dependent DNA helicase activity
HK81_RS09790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HK81_RS09795	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HK81_RS09795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HK81_RS09805	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HK81_RS09810	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HK81_RS09815	COG2166	iron-sulfur cluster assembly
HK81_RS09820	COG3706	GGDEF domain
HK81_RS09825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HK81_RS09830	COG0693	protein deglycase activity
HK81_RS09835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HK81_RS09860	COG1595	DNA-templated transcription, initiation
HK81_RS09880	COG3056	Lipoprotein
HK81_RS09885	COG2813	Specifically methylates the guanine in position
HK81_RS09890	COG0271	Belongs to the BolA IbaG family
HK81_RS09900	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HK81_RS09905	COG1805	sodium ion transport
HK81_RS09910	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HK81_RS09915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HK81_RS09920	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HK81_RS09925	COG2871	sodium ion transport
HK81_RS09930	COG1477	protein flavinylation
HK81_RS09945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HK81_RS09950	COG0514	ATP-dependent DNA helicase (RecQ)
HK81_RS09955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HK81_RS09970	COG0733	neurotransmitter:sodium symporter activity
HK81_RS09990	COG0442	prolyl-tRNA aminoacylation
HK81_RS09995	COG1720	tRNA m6t6A37 methyltransferase activity
HK81_RS10000	COG0254	rRNA binding
HK81_RS10005	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HK81_RS10010	COG1671	Belongs to the UPF0178 family
HK81_RS10030	COG3098	single-species biofilm formation
HK81_RS10035	COG0564	pseudouridine synthase activity
HK81_RS10045	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HK81_RS10050	COG0024	Methionine aminopeptidase
HK81_RS10055	COG0052	Belongs to the universal ribosomal protein uS2 family
HK81_RS10060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HK81_RS10065	COG0528	UMP kinase activity
HK81_RS10070	COG0233	cytoplasmic translational termination
HK81_RS10075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HK81_RS10080	COG0575	Belongs to the CDS family
HK81_RS10085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HK81_RS10090	COG0750	zinc metalloprotease
HK81_RS10100	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HK81_RS10105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HK81_RS10110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HK81_RS10115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HK81_RS10120	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HK81_RS10125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HK81_RS10130	COG0587	DNA-directed DNA polymerase activity
HK81_RS10135	COG0825	malonyl-CoA metabolic process
HK81_RS10140	COG0037	tRNA processing
HK81_RS10150	COG0347	Belongs to the P(II) protein family
HK81_RS10155	COG3021	interspecies interaction between organisms
HK81_RS10165	COG1388	LysM domain
HK81_RS10165	COG0741	lytic transglycosylase activity
HK81_RS10170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HK81_RS10175	COG2226	methyltransferase
HK81_RS10180	COG0328	RNA-DNA hybrid ribonuclease activity
HK81_RS10185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HK81_RS10200	COG1960	acyl-CoA dehydrogenase activity
HK81_RS10205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HK81_RS10210	COG0121	glutamine amidotransferase
HK81_RS10215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HK81_RS10220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HK81_RS10225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HK81_RS10230	COG2233	PERMEase
HK81_RS10250	COG1393	Belongs to the ArsC family
HK81_RS10255	COG4783	chaperone-mediated protein folding
HK81_RS10270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HK81_RS10275	COG2716	regulation of RNA biosynthetic process
HK81_RS10280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HK81_RS10285	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HK81_RS10300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HK81_RS10305	COG1393	Belongs to the ArsC family
HK81_RS10330	COG2837	iron assimilation
HK81_RS10335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK81_RS10340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK81_RS10345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK81_RS10350	COG1334	flagellar protein FlaG
HK81_RS10355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HK81_RS10365	COG1516	flagellar protein fliS
HK81_RS10385	COG1677	Flagellar hook-basal body complex protein FliE
HK81_RS10395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HK81_RS10445	COG1987	bacterial-type flagellum assembly
HK81_RS10450	COG1684	flagellar biosynthetic protein fliR
HK81_RS10485	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HK81_RS10490	COG2198	Histidine kinase
HK81_RS10490	COG0784	Response regulator, receiver
HK81_RS10490	COG0643	Histidine kinase
HK81_RS10495	COG2201	protein-glutamate methylesterase activity
HK81_RS10500	COG1192	Involved in chromosome partitioning
HK81_RS10510	COG0835	chemotaxis
HK81_RS10520	COG4133	protoheme IX ABC transporter activity
HK81_RS10525	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HK81_RS10530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HK81_RS10535	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HK81_RS10540	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HK81_RS10545	COG1138	Cytochrome C-type biogenesis protein
HK81_RS10550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HK81_RS10565	COG2853	Lipoprotein
HK81_RS10570	COG2067	long-chain fatty acid transport protein
HK81_RS10575	COG2067	long-chain fatty acid transport protein
HK81_RS10595	COG0183	Belongs to the thiolase family
HK81_RS10600	COG1250	3-hydroxyacyl-CoA dehydrogenase
HK81_RS10600	COG1024	Enoyl-CoA hydratase
HK81_RS10615	COG2062	phosphohistidine phosphatase, SixA
HK81_RS10620	COG2840	Smr protein MutS2
HK81_RS10625	COG2890	protein-(glutamine-N5) methyltransferase activity
HK81_RS10630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HK81_RS10635	COG2860	membrane
HK81_RS10640	COG3101	peptidyl-lysine hydroxylation
HK81_RS10650	COG0431	NADPH-dependent FMN reductase
HK81_RS10655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HK81_RS10655	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HK81_RS10660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HK81_RS10665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HK81_RS10670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HK81_RS10680	COG0101	tRNA pseudouridine synthase activity
HK81_RS10685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HK81_RS10690	COG0285	dihydrofolate synthase activity
HK81_RS10695	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HK81_RS10700	COG1286	toxin biosynthetic process
HK81_RS10705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HK81_RS10710	COG0583	DNA-binding transcription factor activity
HK81_RS10715	COG0745	RESPONSE REGULATOR receiver
HK81_RS10725	COG2832	Protein of unknown function (DUF454)
HK81_RS10730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HK81_RS10740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HK81_RS10745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HK81_RS10750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HK81_RS10755	COG0814	amino acid
HK81_RS10760	COG0251	oxidation-reduction process
HK81_RS10765	COG3681	Belongs to the UPF0597 family
HK81_RS10780	COG2261	transglycosylase associated protein
HK81_RS10785	COG2983	Belongs to the UPF0260 family
HK81_RS10790	COG0668	transmembrane transport
HK81_RS10800	COG0346	lactoylglutathione lyase activity
HK81_RS10810	COG1785	Belongs to the alkaline phosphatase family
HK81_RS10825	COG2226	methyltransferase
HK81_RS10840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HK81_RS10845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HK81_RS10855	COG3139	Protein of unknown function (DUF1315)
HK81_RS10860	COG0252	asparaginase activity
HK81_RS10865	COG0616	signal peptide processing
HK81_RS10870	COG0446	pyridine nucleotide-disulphide oxidoreductase
HK81_RS10870	COG1902	pentaerythritol trinitrate reductase activity
HK81_RS10875	COG0778	Nitroreductase
HK81_RS10880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HK81_RS10895	COG0123	including yeast histone deacetylase and acetoin utilization protein
HK81_RS10905	COG3083	sulfuric ester hydrolase activity
HK81_RS10910	COG3082	Protein of unknown function (DUF1414)
HK81_RS10915	COG3081	Nucleoid-associated protein
HK81_RS10930	COG1757	Na H antiporter
HK81_RS10935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HK81_RS10940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HK81_RS10945	COG2095	MarC family integral membrane protein
HK81_RS10950	COG1012	belongs to the aldehyde dehydrogenase family
HK81_RS10950	COG1454	alcohol dehydrogenase
HK81_RS10970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HK81_RS10980	COG2056	Na+-H+ antiporter family
HK81_RS10985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HK81_RS10990	COG2885	chlorophyll binding
HK81_RS11000	COG0346	lactoylglutathione lyase activity
HK81_RS11005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HK81_RS11010	COG4660	Part of a membrane complex involved in electron transport
HK81_RS11015	COG4659	FMN binding
HK81_RS11020	COG4658	electron transport chain
HK81_RS11025	COG4656	Part of a membrane complex involved in electron transport
HK81_RS11030	COG2878	Part of a membrane complex involved in electron transport
HK81_RS11035	COG4657	Part of a membrane complex involved in electron transport
HK81_RS11045	COG0556	nucleotide-excision repair
HK81_RS11050	COG2204	response regulator
HK81_RS11055	COG2198	Histidine kinase
HK81_RS11060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HK81_RS11065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HK81_RS11070	COG0521	Mo-molybdopterin cofactor biosynthetic process
HK81_RS11075	COG0315	cyclic pyranopterin monophosphate synthase activity
HK81_RS11080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HK81_RS11085	COG0314	molybdopterin synthase activity
HK81_RS11095	COG0601	transmembrane transport
HK81_RS11100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HK81_RS11105	COG0444	Belongs to the ABC transporter superfamily
HK81_RS11115	COG0435	Glutathione S-transferase
HK81_RS11125	COG3174	membrane
HK81_RS11130	COG0857	belongs to the CobB CobQ family
HK81_RS11130	COG0280	phosphate acetyltransferase
HK81_RS11135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HK81_RS11140	COG3092	negative regulation of chromosome organization
HK81_RS11150	COG4120	Belongs to the binding-protein-dependent transport system permease family
HK81_RS11155	COG1122	ATPase activity
HK81_RS11160	COG0366	Alpha amylase catalytic
HK81_RS11170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HK81_RS11175	COG3318	Belongs to the UPF0149 family
HK81_RS11175	COG3012	SEC-C Motif Domain Protein
HK81_RS11180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HK81_RS11185	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HK81_RS11190	COG2186	Transcriptional regulator
HK81_RS11200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK81_RS11200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK81_RS11205	COG0489	protein tyrosine kinase activity
HK81_RS11210	COG0572	uridine kinase
HK81_RS11220	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HK81_RS11225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HK81_RS11230	COG0659	secondary active sulfate transmembrane transporter activity
HK81_RS11235	COG1530	ribonuclease E activity
HK81_RS11240	COG0564	pseudouridine synthase activity
HK81_RS11245	COG0424	maF-like protein
HK81_RS11250	COG1399	metal-binding, possibly nucleic acid-binding protein
HK81_RS11260	COG0416	fatty acid biosynthetic process
HK81_RS11265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HK81_RS11295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HK81_RS11300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HK81_RS11310	COG0084	hydrolase, TatD family'
HK81_RS11315	COG1263	PTS System
HK81_RS11315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HK81_RS11325	COG0733	neurotransmitter:sodium symporter activity
HK81_RS11340	COG4667	esterase of the alpha-beta hydrolase superfamily
HK81_RS11345	COG0469	pyruvate kinase activity
HK81_RS11350	COG1940	carbohydrate kinase activity
HK81_RS11355	COG0835	chemotaxis
HK81_RS11355	COG0784	Response regulator, receiver
HK81_RS11360	COG0587	DNA-directed DNA polymerase activity
HK81_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
HK81_RS11380	COG0616	signal peptide processing
HK81_RS11385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HK81_RS11390	COG0539	negative regulation of cytoplasmic translation
HK81_RS11400	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HK81_RS11405	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HK81_RS11410	COG0284	orotidine-5'-phosphate decarboxylase activity
HK81_RS11415	COG4166	transmembrane transport
HK81_RS11440	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HK81_RS11450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HK81_RS11450	COG3008	intermembrane lipid transfer
HK81_RS11455	COG2995	paraquat-inducible protein a
HK81_RS11460	COG3258	Cytochrome c
HK81_RS11465	COG2863	cytochrome
HK81_RS11505	COG4232	protein-disulfide reductase activity
HK81_RS11510	COG3118	belongs to the thioredoxin family
HK81_RS11540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK81_RS11550	COG0577	efflux transmembrane transporter activity
HK81_RS11550	COG1136	(ABC) transporter
HK81_RS11555	COG0577	efflux transmembrane transporter activity
HK81_RS11555	COG1136	(ABC) transporter
HK81_RS11560	COG1136	(ABC) transporter
HK81_RS11560	COG0577	efflux transmembrane transporter activity
HK81_RS11565	COG1335	isochorismatase
HK81_RS11615	COG5002	protein histidine kinase activity
HK81_RS11615	COG3850	Histidine kinase
HK81_RS11620	COG0745	RESPONSE REGULATOR receiver
HK81_RS11625	COG0840	transmembrane signaling receptor activity
HK81_RS11630	COG1032	radical SAM domain protein
HK81_RS11635	COG5001	Diguanylate cyclase
HK81_RS11635	COG3706	GGDEF domain
HK81_RS11635	COG2203	Gaf domain
HK81_RS11635	COG4251	negative regulation of phosphorylation
HK81_RS11650	COG0583	DNA-binding transcription factor activity
HK81_RS11655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HK81_RS11665	COG2350	Protein conserved in bacteria
HK81_RS11675	COG2917	probably involved in intracellular septation
HK81_RS11695	COG1301	dicarboxylic acid transport
HK81_RS11700	COG0318	PFAM AMP-dependent synthetase and ligase
HK81_RS11705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HK81_RS11710	COG0159	tryptophan synthase activity
HK81_RS11715	COG0133	tryptophan synthase activity
HK81_RS11720	COG0135	phosphoribosylanthranilate isomerase activity
HK81_RS11720	COG0134	indole-3-glycerol-phosphate synthase activity
HK81_RS11725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HK81_RS11730	COG0512	Glutamine amidotransferase of anthranilate synthase
HK81_RS11735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HK81_RS11745	COG0613	PHP domain protein
HK81_RS11750	COG0009	L-threonylcarbamoyladenylate synthase
HK81_RS11760	COG1187	pseudouridine synthase activity
HK81_RS11765	COG3099	Belongs to the UPF0263 family
HK81_RS11770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HK81_RS11780	COG0417	DNA replication proofreading
HK81_RS11785	COG2197	response regulator
HK81_RS11790	COG0322	excinuclease ABC activity
HK81_RS11830	COG0019	diaminopimelate decarboxylase activity
HK81_RS11855	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HK81_RS11860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HK81_RS11865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HK81_RS11885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HK81_RS11895	COG0437	4 iron, 4 sulfur cluster binding
HK81_RS11900	COG3301	Polysulphide reductase, NrfD
HK81_RS11905	COG1138	Cytochrome C-type biogenesis protein
HK81_RS11915	COG3088	subunit of a heme lyase
HK81_RS11915	COG4235	cytochrome complex assembly
HK81_RS11925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HK81_RS11950	COG2989	Protein conserved in bacteria
HK81_RS11955	COG3108	Peptidase M15
HK81_RS11960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HK81_RS11975	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HK81_RS12000	COG1846	Transcriptional regulator
HK81_RS12005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HK81_RS12030	COG1448	Aminotransferase
HK81_RS12045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HK81_RS12055	COG0017	Asparaginyl-tRNA synthetase
HK81_RS12075	COG0557	exoribonuclease II activity
HK81_RS12080	COG1278	Cold shock
HK81_RS12100	COG0720	synthase
HK81_RS12110	COG2200	EAL domain
HK81_RS12115	COG1760	l-serine dehydratase
HK81_RS12120	COG0814	amino acid
HK81_RS12125	COG0494	nUDIX hydrolase
HK81_RS12135	COG2205	protein histidine kinase activity
HK81_RS12135	COG0784	Response regulator, receiver
HK81_RS12140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HK81_RS12155	COG3106	COG3106 Predicted ATPase
HK81_RS12160	COG3768	UPF0283 membrane protein
HK81_RS12170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HK81_RS12225	COG0653	protein targeting
HK81_RS12230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HK81_RS12235	COG0456	acetyltransferase
HK81_RS12345	COG0346	lactoylglutathione lyase activity
HK81_RS12525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK81_RS12535	COG3791	Glutathione-dependent formaldehyde-activating
HK81_RS12600	COG0346	lactoylglutathione lyase activity
HK81_RS12655	COG0251	oxidation-reduction process
HK81_RS12755	COG3152	Membrane
HK81_RS12760	COG0346	lactoylglutathione lyase activity
HK81_RS12785	COG2801	Transposase and inactivated derivatives
HK81_RS12810	COG1280	lysine exporter protein (LysE YggA)
HK81_RS12815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HK81_RS12835	COG1757	Na H antiporter
HK81_RS12840	COG0174	glutamine synthetase
HK81_RS12845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HK81_RS12850	COG1396	sequence-specific DNA binding
HK81_RS12850	COG1917	Cupin 2, conserved barrel domain protein
HK81_RS12855	COG1012	belongs to the aldehyde dehydrogenase family
HK81_RS12860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HK81_RS12870	COG2957	Belongs to the agmatine deiminase family
HK81_RS12875	COG1012	belongs to the aldehyde dehydrogenase family
HK81_RS12880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HK81_RS12885	COG1227	inorganic diphosphatase activity
HK81_RS12890	COG2200	EAL domain
HK81_RS12890	COG2771	luxR family
HK81_RS12905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HK81_RS12920	COG1846	Transcriptional regulator
HK81_RS12925	COG2315	Protein conserved in bacteria
HK81_RS12945	COG0110	maltose O-acetyltransferase activity
HK81_RS12975	COG3063	Type IV pilus biogenesis stability protein PilW
HK81_RS12980	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HK81_RS12990	COG0531	amino acid
HK81_RS13000	COG1560	Kdo2-lipid A biosynthetic process
HK81_RS13005	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HK81_RS13010	COG1280	lysine exporter protein (LysE YggA)
HK81_RS13020	COG1115	amino acid carrier protein
HK81_RS13045	COG1368	sulfuric ester hydrolase activity
HK81_RS13050	COG0642	Histidine kinase
HK81_RS13055	COG0745	RESPONSE REGULATOR receiver
HK81_RS13065	COG1028	Short-chain dehydrogenase reductase Sdr
HK81_RS13085	COG2113	Glycine betaine
HK81_RS13090	COG4176	ABC-type proline glycine betaine transport system permease component
HK81_RS13110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HK81_RS13115	COG0456	acetyltransferase
HK81_RS13120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HK81_RS13125	COG0662	Cupin 2, conserved barrel domain protein
HK81_RS13130	COG0527	aspartate kinase activity
HK81_RS13135	COG1858	cytochrome C peroxidase
HK81_RS13150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK81_RS13165	COG3290	protein histidine kinase activity
HK81_RS13170	COG4565	transcriptional regulatory protein
HK81_RS13175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HK81_RS13180	COG0363	glucosamine-6-phosphate deaminase activity
HK81_RS13185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HK81_RS13200	COG3284	Transcriptional regulator
HK81_RS13205	COG1012	belongs to the aldehyde dehydrogenase family
HK81_RS13275	COG4669	(LipO)protein
HK81_RS13295	COG3177	Filamentation induced by cAMP protein fic
HK81_RS13325	COG1073	alpha beta
HK81_RS13330	COG1073	alpha beta
HK81_RS13340	COG4792	protein secretion
HK81_RS13345	COG4791	protein targeting
HK81_RS13350	COG4794	Type iii secretion
HK81_RS13355	COG4790	Type iii secretion
HK81_RS13425	COG0457	Tetratricopeptide repeat
HK81_RS13445	COG0730	response to heat
HK81_RS13475	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HK81_RS13480	COG0372	Belongs to the citrate synthase family
HK81_RS13490	COG2828	Protein conserved in bacteria
HK81_RS13515	COG0561	phosphatase activity
HK81_RS13520	COG0602	queuosine metabolic process
HK81_RS13525	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HK81_RS13530	COG3706	GGDEF domain
HK81_RS13570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HK81_RS13575	COG0840	transmembrane signaling receptor activity
HK81_RS13580	COG1254	Belongs to the acylphosphatase family
HK81_RS13585	COG2920	part of a sulfur-relay system
HK81_RS13595	COG0670	Belongs to the BI1 family
HK81_RS13600	COG1126	abc transporter atp-binding protein
HK81_RS13605	COG0765	amino acid transport
HK81_RS13610	COG4597	amino acid ABC transporter
HK81_RS13615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HK81_RS13625	COG1666	GTP binding
HK81_RS13630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HK81_RS13650	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HK81_RS13650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HK81_RS13655	COG3008	intermembrane lipid transfer
HK81_RS13660	COG2995	paraquat-inducible protein a
HK81_RS13665	COG1132	(ABC) transporter
HK81_RS13670	COG1956	GAF domain-containing protein
HK81_RS13675	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HK81_RS13690	COG0308	aminopeptidase N
HK81_RS13695	COG2902	Dehydrogenase
HK81_RS13700	COG0167	dihydroorotate dehydrogenase activity
HK81_RS13710	COG0116	Belongs to the methyltransferase superfamily
HK81_RS13710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HK81_RS13720	COG0488	(ABC) transporter
HK81_RS13735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HK81_RS13740	COG1067	ATP-dependent peptidase activity
HK81_RS13745	COG3120	sequence-specific DNA binding
HK81_RS13760	COG0784	Response regulator, receiver
HK81_RS13760	COG2205	protein histidine kinase activity
HK81_RS13775	COG3278	Belongs to the heme-copper respiratory oxidase family
HK81_RS13790	COG2010	Cytochrome c
HK81_RS13800	COG2217	Heavy metal translocating P-type atpase
HK81_RS13815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HK81_RS13820	COG0589	response to stress
HK81_RS13825	COG0037	tRNA processing
HK81_RS13845	COG3842	ATPase activity
HK81_RS13855	COG1177	transmembrane transport
HK81_RS13865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HK81_RS13870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HK81_RS13880	COG0004	ammonium transporteR
HK81_RS13945	COG0437	4 iron, 4 sulfur cluster binding
HK81_RS13950	COG0243	molybdopterin cofactor binding
HK81_RS13950	COG3383	formate dehydrogenase (NAD+) activity
HK81_RS13960	COG3381	protein complex oligomerization
HK81_RS13980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HK81_RS13990	COG0488	(ABC) transporter
HK81_RS13995	COG4191	Histidine kinase
HK81_RS14000	COG2204	response regulator
HK81_RS14015	COG3842	ATPase activity
HK81_RS14020	COG0746	molybdenum cofactor guanylyltransferase activity
HK81_RS14025	COG0303	'Molybdopterin
HK81_RS14035	COG1940	carbohydrate kinase activity
HK81_RS14040	COG3148	PFAM DTW domain containing protein
HK81_RS14075	COG0840	transmembrane signaling receptor activity
HK81_RS14080	COG0791	NLP P60 protein
HK81_RS14090	COG3706	GGDEF domain
HK81_RS14095	COG2201	protein-glutamate methylesterase activity
HK81_RS14100	COG3001	Fructosamine kinase
HK81_RS14110	COG0307	riboflavin synthase, alpha
HK81_RS14115	COG0534	Mate efflux family protein
HK81_RS14125	COG1793	dna ligase
HK81_RS14155	COG2204	response regulator
HK81_RS14195	COG0438	transferase activity, transferring glycosyl groups
HK81_RS14200	COG1215	transferase activity, transferring glycosyl groups
HK81_RS14205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HK81_RS14215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HK81_RS14230	COG1643	Atp-dependent helicase
HK81_RS14235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HK81_RS14250	COG3302	dmso reductase anchor subunit
HK81_RS14255	COG0437	4 iron, 4 sulfur cluster binding
HK81_RS14260	COG0243	molybdopterin cofactor binding
HK81_RS14290	COG3706	GGDEF domain
HK81_RS14300	COG0443	Heat shock 70 kDa protein
HK81_RS14305	COG0443	Heat shock 70 kDa protein
HK81_RS14330	COG1132	(ABC) transporter
HK81_RS14335	COG1132	(ABC) transporter
HK81_RS14355	COG0814	amino acid
HK81_RS14365	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HK81_RS14445	COG1522	sequence-specific DNA binding
HK81_RS14480	COG0515	serine threonine protein kinase
HK81_RS14505	COG3501	Rhs element vgr protein
HK81_RS14520	COG2204	response regulator
HK81_RS14545	COG0739	heme binding
HK81_RS14550	COG0861	Integral membrane protein TerC family
HK81_RS14560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HK81_RS14565	COG1328	CTP reductase activity
HK81_RS14570	COG1280	lysine exporter protein (LysE YggA)
HK81_RS14580	COG5001	Diguanylate cyclase
HK81_RS14580	COG3300	MHYT domain
HK81_RS14595	COG0471	metal ion transport
HK81_RS14630	COG0583	DNA-binding transcription factor activity
HK81_RS14695	COG0625	glutathione transferase activity
HK81_RS14705	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HK81_RS14720	COG2195	Cleaves the N-terminal amino acid of tripeptides
HK81_RS14730	COG0601	transmembrane transport
HK81_RS14735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HK81_RS14740	COG0444	Belongs to the ABC transporter superfamily
HK81_RS14755	COG3291	Pkd domain containing protein
HK81_RS14765	COG1177	transmembrane transport
HK81_RS14770	COG1176	ABC-type spermidine putrescine transport system, permease component I
HK81_RS14775	COG3842	ATPase activity
HK81_RS14780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HK81_RS14785	COG2423	ornithine cyclodeaminase activity
HK81_RS14800	COG3938	Belongs to the proline racemase family
HK81_RS14830	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HK81_RS14835	COG1451	nucleotide metabolic process
HK81_RS14840	COG3475	LICD family
HK81_RS14845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HK81_RS14850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HK81_RS14870	COG0583	DNA-binding transcription factor activity
HK81_RS14890	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HK81_RS14895	COG4139	cobalamin transport
HK81_RS14900	COG2988	succinylglutamate desuccinylase activity
HK81_RS14910	COG2062	phosphohistidine phosphatase, SixA
HK81_RS14920	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HK81_RS14925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HK81_RS14930	COG0702	epimerase
HK81_RS14935	COG1823	symporter activity
HK81_RS14940	COG2925	Exonuclease
HK81_RS14945	COG1380	Effector of murein hydrolase LrgA
HK81_RS14950	COG1346	cytolysis
HK81_RS14955	COG0295	cytidine deaminase activity
HK81_RS14960	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HK81_RS14965	COG0500	methyltransferase
HK81_RS14975	COG0776	regulation of translation
HK81_RS14985	COG0072	phenylalanine-tRNA ligase activity
HK81_RS14985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK81_RS14990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HK81_RS14995	COG3706	GGDEF domain
HK81_RS15025	COG0393	Putative heavy-metal-binding
HK81_RS15035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HK81_RS15045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HK81_RS15060	COG2188	Transcriptional regulator
HK81_RS15065	COG1228	amidohydrolase
HK81_RS15070	COG0010	Belongs to the arginase family
HK81_RS15075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HK81_RS15080	COG2986	histidine ammonia-lyase
HK81_RS15095	COG0247	lactate metabolic process
HK81_RS15095	COG0277	FAD linked oxidase domain protein
HK81_RS15130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HK81_RS15145	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HK81_RS15150	COG1643	Atp-dependent helicase
HK81_RS15155	COG0281	malic enzyme
HK81_RS15160	COG2949	membrane
HK81_RS15165	COG0471	metal ion transport
HK81_RS15190	COG0492	ferredoxin-NADP+ reductase activity
HK81_RS15195	COG4988	ABC transporter
HK81_RS15200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HK81_RS15205	COG3048	D-serine ammonia-lyase activity
HK81_RS15210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HK81_RS15220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HK81_RS15220	COG4191	Histidine kinase
HK81_RS15235	COG3070	regulator of competence-specific genes
HK81_RS15250	COG2431	L-lysine efflux transmembrane transporter activity
HK81_RS15260	COG0076	glutamate decarboxylase activity
HK81_RS15265	COG1737	Transcriptional regulator
HK81_RS15275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HK81_RS15280	COG2985	domain, Protein
HK81_RS15280	COG3273	potassium ion transport
HK81_RS15285	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HK81_RS15300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HK81_RS15315	COG4181	ATPase activity
HK81_RS15320	COG0534	Mate efflux family protein
HK81_RS15325	COG0702	epimerase
HK81_RS15330	COG3005	denitrification pathway
HK81_RS15360	COG2814	Major facilitator Superfamily
HK81_RS15365	COG1187	pseudouridine synthase activity
HK81_RS15370	COG1061	Type III restriction enzyme res subunit
HK81_RS15390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HK81_RS15415	COG3313	Fe-S protein
HK81_RS15440	COG0493	'glutamate synthase
HK81_RS15450	COG0398	Pfam SNARE associated Golgi protein
HK81_RS15455	COG4134	Bacterial extracellular solute-binding protein
HK81_RS15460	COG4135	transport system, permease component
HK81_RS15465	COG4136	ATPase activity
HK81_RS15470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HK81_RS15480	COG3604	Transcriptional regulator
HK81_RS15485	COG1151	hydroxylamine reductase activity
HK81_RS15490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HK81_RS15500	COG0564	pseudouridine synthase activity
HK81_RS15510	COG0733	neurotransmitter:sodium symporter activity
HK81_RS15520	COG0626	cystathionine gamma-synthase activity
HK81_RS15525	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HK81_RS15530	COG5380	lipid catabolic process
HK81_RS15535	COG2818	Glycosylase
HK81_RS15550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK81_RS15555	COG1983	PspC domain protein
HK81_RS15565	COG1842	Phage shock protein A
HK81_RS15570	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HK81_RS15585	COG4171	peptide transport system, permease
HK81_RS15595	COG4172	Belongs to the ABC transporter superfamily
HK81_RS15605	COG1227	inorganic diphosphatase activity
HK81_RS15620	COG0243	molybdopterin cofactor binding
HK81_RS15625	COG3005	denitrification pathway
HK81_RS15630	COG4459	periplasmic nitrate reductase
HK81_RS15635	COG0390	transport system, permease component
HK81_RS15640	COG2116	formate transmembrane transporter activity
HK81_RS15665	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HK81_RS15670	COG1435	thymidine kinase activity
HK81_RS15675	COG0215	cysteine-tRNA ligase activity
HK81_RS15680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HK81_RS15685	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HK81_RS15690	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HK81_RS15695	COG3012	SEC-C Motif Domain Protein
HK81_RS15700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HK81_RS15700	COG0140	phosphoribosyl-ATP diphosphatase activity
HK81_RS15705	COG0107	imidazoleglycerol-phosphate synthase activity
HK81_RS15710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HK81_RS15715	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HK81_RS15720	COG0131	Imidazoleglycerol-phosphate dehydratase
HK81_RS15720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HK81_RS15725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HK81_RS15730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HK81_RS15735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HK81_RS15750	COG1757	Na H antiporter
HK81_RS15760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HK81_RS15770	COG0482	sulfurtransferase activity
HK81_RS15775	COG2915	High frequency lysogenization protein hflD homolog
HK81_RS15780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HK81_RS15800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HK81_RS15815	COG0300	oxidoreductase activity
HK81_RS15825	COG0501	Belongs to the peptidase M48B family
HK81_RS15830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HK81_RS15840	COG0156	8-amino-7-oxononanoate synthase activity
HK81_RS15845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HK81_RS15850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HK81_RS15855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HK81_RS15870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HK81_RS15875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HK81_RS15880	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HK81_RS15885	COG1674	ftsk spoiiie
HK81_RS15895	COG0686	Belongs to the AlaDH PNT family
HK81_RS15905	COG0583	DNA-binding transcription factor activity
HK81_RS15920	COG3568	Endonuclease Exonuclease Phosphatase
HK81_RS15945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HK81_RS15950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK81_RS15955	COG0840	transmembrane signaling receptor activity
HK81_RS15970	COG5002	protein histidine kinase activity
HK81_RS15970	COG0784	Response regulator, receiver
HK81_RS15980	COG0754	glutathionylspermidine amidase activity
HK81_RS15990	COG3766	membrane
HK81_RS16000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HK81_RS16005	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HK81_RS16010	COG2885	chlorophyll binding
HK81_RS16015	COG0823	Involved in the tonB-independent uptake of proteins
HK81_RS16030	COG0811	peptide transport
HK81_RS16035	COG0824	Thioesterase
HK81_RS16050	COG1294	oxidase, subunit
HK81_RS16055	COG1271	oxidase subunit
HK81_RS16060	COG2255	four-way junction helicase activity
HK81_RS16065	COG0632	four-way junction helicase activity
HK81_RS16070	COG0840	transmembrane signaling receptor activity
HK81_RS16075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HK81_RS16080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HK81_RS16085	COG1801	Protein of unknown function DUF72
HK81_RS16090	COG4106	trans-aconitate 2-methyltransferase activity
HK81_RS16095	COG0500	methyltransferase
HK81_RS16100	COG0189	ligase activity
HK81_RS16100	COG4067	protein conserved in archaea
HK81_RS16115	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HK81_RS16120	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HK81_RS16125	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HK81_RS16130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HK81_RS16135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HK81_RS16140	COG0745	RESPONSE REGULATOR receiver
HK81_RS16145	COG3381	protein complex oligomerization
HK81_RS16150	COG1609	Transcriptional regulator
HK81_RS16155	COG3070	regulator of competence-specific genes
HK81_RS16175	COG0297	glycogen (starch) synthase activity
HK81_RS16180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HK81_RS16185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HK81_RS16195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HK81_RS16205	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HK81_RS16210	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HK81_RS16215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HK81_RS16225	COG0542	response to heat
HK81_RS16230	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HK81_RS16235	COG1278	Cold shock
HK81_RS16245	COG1187	pseudouridine synthase activity
HK81_RS16250	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HK81_RS16260	COG1199	ATP-dependent helicase activity
HK81_RS16265	COG0730	response to heat
HK81_RS16270	COG3923	Primosomal replication protein n
HK81_RS16280	COG0708	Exodeoxyribonuclease III
HK81_RS16320	COG1882	Formate acetyltransferase
HK81_RS16330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HK81_RS16340	COG3013	Belongs to the UPF0304 family
HK81_RS16345	COG2766	serine protein kinase
HK81_RS16350	COG2718	Belongs to the UPF0229 family
HK81_RS16355	COG2719	SpoVR family
HK81_RS16360	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HK81_RS16370	COG1663	tetraacyldisaccharide 4'-kinase activity
HK81_RS16375	COG1132	(ABC) transporter
HK81_RS16380	COG2333	competence protein COMEC
HK81_RS16380	COG0658	competence protein
HK81_RS16390	COG4591	ABC-type transport system involved in lipoprotein release permease component
HK81_RS16395	COG1136	(ABC) transporter
HK81_RS16400	COG4591	ABC-type transport system involved in lipoprotein release permease component
HK81_RS16410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HK81_RS16425	COG1252	NADH dehydrogenase
HK81_RS16430	COG3150	esterase
HK81_RS16455	COG0537	adenosine 5'-monophosphoramidase activity
HK81_RS16480	COG0517	IMP dehydrogenase activity
HK81_RS16480	COG0516	GMP reductase activity
HK81_RS16485	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HK81_RS16490	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HK81_RS16495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HK81_RS16500	COG2199	diguanylate cyclase activity
HK81_RS16515	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HK81_RS16520	COG1946	Acyl-CoA thioesterase
HK81_RS16530	COG1522	sequence-specific DNA binding
HK81_RS16555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HK81_RS16560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK81_RS16605	COG0477	Major facilitator Superfamily
HK81_RS16610	COG2855	membrane
HK81_RS16630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HK81_RS16635	COG0596	Alpha beta hydrolase
HK81_RS16640	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HK81_RS16645	COG1169	isochorismate synthase
HK81_RS16650	COG0436	Aminotransferase
HK81_RS16655	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HK81_RS16660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HK81_RS16680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HK81_RS16685	COG0776	regulation of translation
HK81_RS16690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HK81_RS16695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HK81_RS16705	COG0544	peptidyl-prolyl cis-trans isomerase activity
HK81_RS16720	COG2204	response regulator
HK81_RS16730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HK81_RS16735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HK81_RS16740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HK81_RS16745	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HK81_RS16760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HK81_RS16765	COG0569	domain protein
HK81_RS16770	COG0513	Belongs to the DEAD box helicase family
HK81_RS16775	COG1253	flavin adenine dinucleotide binding
HK81_RS16810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HK81_RS16815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HK81_RS16830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HK81_RS16835	COG1216	Glycosyl transferase, family 2
HK81_RS16840	COG2986	histidine ammonia-lyase
HK81_RS16865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HK81_RS16875	COG1028	Short-chain dehydrogenase reductase Sdr
HK81_RS16915	COG0210	DNA helicase
HK81_RS16925	COG0497	DNA recombination
HK81_RS16970	COG3550	peptidyl-serine autophosphorylation
HK81_RS17000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HK81_RS17005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HK81_RS17010	COG0583	DNA-binding transcription factor activity
HK81_RS17015	COG2951	lytic endotransglycosylase activity
HK81_RS17020	COG3100	YcgL domain-containing protein
HK81_RS17025	COG0850	regulation of cytokinetic process
HK81_RS17030	COG2894	cell division
HK81_RS17035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HK81_RS17040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HK81_RS17045	COG0318	PFAM AMP-dependent synthetase and ligase
HK81_RS17050	COG2267	carboxylic ester hydrolase activity
HK81_RS17065	COG1214	PFAM Peptidase M22, glycoprotease
HK81_RS17070	COG1199	ATP-dependent helicase activity
HK81_RS17075	COG0788	formyltetrahydrofolate deformylase activity
HK81_RS17085	COG0018	arginyl-trna synthetase
HK81_RS17105	COG1918	ferrous iron import across plasma membrane
HK81_RS17110	COG4977	sequence-specific DNA binding
HK81_RS17115	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HK81_RS17120	COG1121	(ABC) transporter
HK81_RS17125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HK81_RS17135	COG0045	succinate-CoA ligase (ADP-forming) activity
HK81_RS17140	COG0508	dehydrogenase complex catalyzes the overall conversion of
HK81_RS17145	COG0567	Dehydrogenase, E1 component
HK81_RS17150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HK81_RS17155	COG1053	succinate dehydrogenase
HK81_RS17160	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HK81_RS17175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HK81_RS17185	COG0033	Phosphoglucomutase
HK81_RS17190	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HK81_RS17195	COG0596	Alpha beta hydrolase
HK81_RS17215	COG0735	belongs to the Fur family
HK81_RS17220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HK81_RS17225	COG1263	PTS System
HK81_RS17225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HK81_RS17230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HK81_RS17235	COG1940	carbohydrate kinase activity
HK81_RS17235	COG1846	Transcriptional regulator
HK81_RS17240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HK81_RS17240	COG4651	solute:proton antiporter activity
HK81_RS17245	COG0367	asparagine synthase
HK81_RS17250	COG0250	Participates in transcription elongation, termination and antitermination
HK81_RS17255	COG3104	oligopeptide transport
HK81_RS17260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HK81_RS17265	COG0563	adenylate kinase activity
HK81_RS17270	COG0326	Molecular chaperone. Has ATPase activity
HK81_RS17275	COG3710	Transcriptional regulator
HK81_RS17295	COG0622	Phosphoesterase
HK81_RS17320	COG1090	epimerase
HK81_RS17325	COG0300	oxidoreductase activity
HK81_RS17330	COG3118	belongs to the thioredoxin family
HK81_RS17335	COG0330	HflC and HflK could
HK81_RS17355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HK81_RS17360	COG3115	cell septum assembly
HK81_RS17365	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HK81_RS17370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HK81_RS17375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK81_RS17380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HK81_RS17385	COG2190	(PTS) system
HK81_RS17390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK81_RS17395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK81_RS17400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK81_RS17405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK81_RS17415	COG3951	Flagellar rod assembly protein muramidase FlgJ
HK81_RS17415	COG1705	Flagellar rod assembly protein muramidase FlgJ
HK81_RS17420	COG1706	bacterial-type flagellum-dependent cell motility
HK81_RS17425	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HK81_RS17435	COG4787	bacterial-type flagellum-dependent cell motility
HK81_RS17440	COG1749	Flagellar hook protein flgE
HK81_RS17450	COG1558	bacterial-type flagellum-dependent cell motility
HK81_RS17455	COG1815	bacterial-type flagellum-dependent cell motility
HK81_RS17460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HK81_RS17465	COG0835	chemotaxis
HK81_RS17465	COG0784	Response regulator, receiver
HK81_RS17515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HK81_RS17520	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HK81_RS17530	COG2608	mercury ion transmembrane transporter activity
HK81_RS17530	COG2217	Heavy metal translocating P-type atpase
HK81_RS17565	COG2840	Smr protein MutS2
HK81_RS17570	COG1187	pseudouridine synthase activity
HK81_RS17580	COG0737	Belongs to the 5'-nucleotidase family
HK81_RS17585	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HK81_RS17590	COG2912	Transglutaminase-like superfamily
HK81_RS17595	COG3094	Invasion gene expression up-regulator, SirB
HK81_RS17600	COG2890	protein-(glutamine-N5) methyltransferase activity
HK81_RS17605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HK81_RS17610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HK81_RS17615	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HK81_RS17620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HK81_RS17625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HK81_RS17630	COG0193	aminoacyl-tRNA hydrolase activity
HK81_RS17635	COG0012	GTP binding
HK81_RS17750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HK81_RS17755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HK81_RS17760	COG1702	phosphate starvation-inducible protein PhoH
HK81_RS17765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HK81_RS17770	COG4535	Mg2 and Co2 transporter CorC
HK81_RS17775	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HK81_RS17780	COG2888	peptidyl-tyrosine sulfation
HK81_RS17785	COG0495	leucyl-tRNA aminoacylation
HK81_RS17790	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HK81_RS17795	COG1466	dna polymerase III delta subunit
HK81_RS17800	COG0799	negative regulation of ribosome biogenesis
HK81_RS17805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HK81_RS17810	COG0768	penicillin binding
HK81_RS17815	COG0772	Belongs to the SEDS family
HK81_RS17820	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HK81_RS17825	COG1686	Belongs to the peptidase S11 family
HK81_RS17830	COG2921	Belongs to the UPF0250 family
HK81_RS17835	COG0321	lipoyl(octanoyl) transferase activity
HK81_RS17840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HK81_RS17845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HK81_RS17850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HK81_RS17865	COG0366	Alpha amylase catalytic
HK81_RS17870	COG1263	PTS System
HK81_RS17870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HK81_RS17880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HK81_RS17885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HK81_RS17890	COG2011	ABC-type metal ion transport system permease component
HK81_RS17895	COG1464	Belongs to the NlpA lipoprotein family
HK81_RS17900	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HK81_RS17910	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HK81_RS17910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HK81_RS17925	COG1611	Belongs to the LOG family
HK81_RS17930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HK81_RS17940	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HK81_RS17945	COG2363	Small membrane protein
HK81_RS17955	COG0583	DNA-binding transcription factor activity
HK81_RS17960	COG0301	tRNA thio-modification
HK81_RS17960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HK81_RS17970	COG2885	chlorophyll binding
HK81_RS17975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HK81_RS17980	COG1722	exodeoxyribonuclease VII activity
HK81_RS17985	COG0142	geranyltranstransferase activity
HK81_RS17990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HK81_RS17995	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HK81_RS18000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HK81_RS18005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HK81_RS18025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HK81_RS18025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HK81_RS18030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HK81_RS18035	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HK81_RS18040	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HK81_RS18050	COG1073	alpha beta
HK81_RS18055	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HK81_RS18060	COG2252	PERMEase
HK81_RS18065	COG2195	Cleaves the N-terminal amino acid of tripeptides
HK81_RS18090	COG0047	phosphoribosylformylglycinamidine synthase activity
HK81_RS18090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HK81_RS18095	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HK81_RS18105	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HK81_RS18135	COG0484	heat shock protein binding
HK81_RS18140	COG0443	Heat shock 70 kDa protein
HK81_RS18150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HK81_RS18155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HK81_RS18165	COG0497	DNA recombination
HK81_RS18170	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HK81_RS18175	COG2914	Belongs to the UPF0125 (RnfH) family
HK81_RS18180	COG2867	negative regulation of translational initiation
HK81_RS18185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HK81_RS18195	COG0328	RNA-DNA hybrid ribonuclease activity
HK81_RS18225	COG0583	DNA-binding transcription factor activity
HK81_RS18230	COG3153	acetyltransferase
HK81_RS18230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HK81_RS18250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HK81_RS18255	COG2873	o-acetylhomoserine
HK81_RS18285	COG1115	amino acid carrier protein
HK81_RS18295	COG1584	GPR1 FUN34 yaaH family protein
HK81_RS18305	COG1757	Na H antiporter
HK81_RS18310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HK81_RS18310	COG0519	Catalyzes the synthesis of GMP from XMP
HK81_RS18315	COG0517	IMP dehydrogenase activity
HK81_RS18315	COG0516	GMP reductase activity
HK81_RS18320	COG1570	exodeoxyribonuclease VII activity
HK81_RS18335	COG1160	GTP binding
HK81_RS18340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HK81_RS18345	COG2976	Protein conserved in bacteria
HK81_RS18350	COG0124	histidyl-tRNA synthetase
HK81_RS18355	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HK81_RS18365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HK81_RS18370	COG0105	UTP biosynthetic process
HK81_RS18375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HK81_RS18380	COG2975	iron-sulfur cluster assembly
HK81_RS18385	COG0633	Ferredoxin
HK81_RS18390	COG0443	Heat shock 70 kDa protein
HK81_RS18395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HK81_RS18405	COG0822	iron-sulfur transferase activity
HK81_RS18410	COG1104	cysteine desulfurase activity
HK81_RS18425	COG0483	inositol monophosphate 1-phosphatase activity
HK81_RS18430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HK81_RS18435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HK81_RS18440	COG1862	Preprotein translocase
HK81_RS18445	COG0343	queuine tRNA-ribosyltransferase activity
HK81_RS18450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HK81_RS18460	COG0517	IMP dehydrogenase activity
HK81_RS18470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HK81_RS18475	COG0583	DNA-binding transcription factor activity
HK81_RS18480	COG0450	alkyl hydroperoxide reductase
HK81_RS18485	COG3142	Participates in the control of copper homeostasis
HK81_RS18495	COG0704	Plays a role in the regulation of phosphate uptake
HK81_RS18500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HK81_RS18505	COG0581	inorganic phosphate transmembrane transporter activity
HK81_RS18515	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HK81_RS18520	COG0248	Ppx GppA phosphatase
HK81_RS18530	COG5002	protein histidine kinase activity
HK81_RS18535	COG0745	RESPONSE REGULATOR receiver
HK81_RS18540	COG2974	May be involved in recombination
HK81_RS18545	COG0826	peptidase U32
HK81_RS18550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HK81_RS18605	COG0542	response to heat
HK81_RS18615	COG0564	pseudouridine synthase activity
HK81_RS18620	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HK81_RS18625	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HK81_RS18630	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HK81_RS18635	COG0077	Prephenate dehydratase
HK81_RS18635	COG1605	Chorismate mutase
HK81_RS18640	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HK81_RS18645	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HK81_RS18655	COG0488	(ABC) transporter
HK81_RS18670	COG0739	heme binding
HK81_RS18675	COG1605	Chorismate mutase
HK81_RS18675	COG0287	Prephenate dehydrogenase
HK81_RS18680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HK81_RS18685	COG1472	Belongs to the glycosyl hydrolase 3 family
HK81_RS18690	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HK81_RS18695	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HK81_RS18710	COG1966	Carbon starvation protein
HK81_RS18715	COG3275	phosphorelay sensor kinase activity
HK81_RS18720	COG3279	Response regulator of the LytR AlgR family
HK81_RS18725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HK81_RS18730	COG1047	Peptidyl-prolyl cis-trans
HK81_RS18735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HK81_RS18740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HK81_RS18745	COG0196	riboflavin kinase activity
HK81_RS18750	COG0728	peptidoglycan biosynthetic process
HK81_RS18755	COG0268	Binds directly to 16S ribosomal RNA
HK81_RS18760	COG0640	Transcriptional regulator
HK81_RS18765	COG0583	DNA-binding transcription factor activity
HK81_RS18770	COG1283	sodium-dependent phosphate transmembrane transporter activity
HK81_RS18780	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HK81_RS18785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HK81_RS18790	COG0730	response to heat
HK81_RS18800	COG0494	nUDIX hydrolase
HK81_RS18805	COG3066	DNA modification
HK81_RS18815	COG0667	Aldo Keto reductase
HK81_RS18830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HK81_RS18835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HK81_RS18840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HK81_RS18845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HK81_RS18850	COG4974	Belongs to the 'phage' integrase family
HK81_RS18855	COG0716	FMN binding
HK81_RS18865	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HK81_RS18870	COG0513	Belongs to the DEAD box helicase family
HK81_RS18875	COG3022	response to hydroperoxide
HK81_RS18880	COG1115	amino acid carrier protein
HK81_RS18895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HK81_RS18900	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HK81_RS18905	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HK81_RS18910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HK81_RS18915	COG0083	homoserine kinase activity
HK81_RS18930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HK81_RS18940	COG0745	RESPONSE REGULATOR receiver
HK81_RS18950	COG5002	protein histidine kinase activity
HK81_RS18950	COG0784	Response regulator, receiver
HK81_RS18950	COG2198	Histidine kinase
HK81_RS18955	COG3706	GGDEF domain
HK81_RS18955	COG4251	negative regulation of phosphorylation
HK81_RS18955	COG5001	Diguanylate cyclase
HK81_RS18955	COG2203	Gaf domain
HK81_RS18960	COG1242	4 iron, 4 sulfur cluster binding
HK81_RS18965	COG0067	glutamate synthase
HK81_RS18965	COG0069	glutamate synthase activity
HK81_RS18965	COG0070	glutamate synthase
HK81_RS18975	COG0067	glutamate synthase
HK81_RS18975	COG0069	glutamate synthase activity
HK81_RS18975	COG0070	glutamate synthase
HK81_RS18980	COG0493	'glutamate synthase
HK81_RS18990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HK81_RS19000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HK81_RS19005	COG2860	membrane
HK81_RS19010	COG0583	DNA-binding transcription factor activity
HK81_RS19015	COG0730	response to heat
HK81_RS19030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HK81_RS19035	COG0505	Belongs to the CarA family
HK81_RS19040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HK81_RS19045	COG0494	nUDIX hydrolase
HK81_RS19050	COG0653	protein targeting
HK81_RS19060	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HK81_RS19065	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HK81_RS19070	COG0849	cell division
HK81_RS19075	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HK81_RS19080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HK81_RS19085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HK81_RS19090	COG0772	Belongs to the SEDS family
HK81_RS19095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HK81_RS19100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HK81_RS19105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HK81_RS19110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HK81_RS19115	COG0768	penicillin binding
HK81_RS19120	COG3116	cell division
HK81_RS19125	COG0275	rRNA processing
HK81_RS19130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HK81_RS19140	COG0792	nuclease activity
HK81_RS19145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HK81_RS19150	COG2823	Periplasmic or secreted lipoprotein
HK81_RS19155	COG2969	positive regulation of protein catabolic process
HK81_RS19160	COG0625	glutathione transferase activity
HK81_RS19165	COG2857	Cytochrome c1
HK81_RS19170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HK81_RS19175	COG0723	plastoquinol--plastocyanin reductase activity
HK81_RS19180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HK81_RS19185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HK81_RS19190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HK81_RS19195	COG3105	Protein conserved in bacteria
HK81_RS19205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HK81_RS19210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HK81_RS19220	COG3150	esterase
HK81_RS19230	COG3151	Protein conserved in bacteria
HK81_RS19235	COG0494	nUDIX hydrolase
HK81_RS19240	COG1538	Outer membrane efflux protein
HK81_RS19245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HK81_RS19245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HK81_RS19250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HK81_RS19265	COG3025	triphosphatase activity
HK81_RS19270	COG1392	Phosphate transport regulator
HK81_RS19275	COG0306	phosphate transporter
HK81_RS19280	COG4991	sh3 domain protein
HK81_RS19290	COG3409	Peptidoglycan-binding domain 1 protein
HK81_RS19290	COG3267	Type II secretory pathway component ExeA
HK81_RS19295	COG0617	tRNA 3'-terminal CCA addition
HK81_RS19300	COG1968	undecaprenyl-diphosphatase activity
HK81_RS19305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HK81_RS19310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HK81_RS19315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HK81_RS19320	COG0596	Alpha beta hydrolase
HK81_RS19325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HK81_RS19330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HK81_RS19335	COG1610	YqeY-like protein
HK81_RS19340	COG0358	DNA primase activity
HK81_RS19360	COG3550	peptidyl-serine autophosphorylation
HK81_RS19380	COG0210	DNA helicase
HK81_RS19410	COG3550	peptidyl-serine autophosphorylation
HK81_RS19430	COG1566	PFAM secretion protein HlyD family protein
HK81_RS19455	COG1464	Belongs to the NlpA lipoprotein family
HK81_RS19485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK81_RS19485	COG2213	PTS system mannitol-specific
HK81_RS19490	COG0246	Mannitol dehydrogenase
HK81_RS19495	COG3722	fumarate hydratase activity
HK81_RS19510	COG1461	Dihydroxyacetone kinase
HK81_RS19515	COG2376	Dihydroxyacetone kinase
HK81_RS19525	COG5002	protein histidine kinase activity
HK81_RS19540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HK81_RS19545	COG1349	DNA-binding transcription factor activity
HK81_RS19550	COG0469	pyruvate kinase activity
HK81_RS19565	COG0440	acetolactate synthase activity
HK81_RS19570	COG0028	Belongs to the TPP enzyme family
HK81_RS19575	COG1022	Amp-dependent synthetase and ligase
HK81_RS19580	COG0583	DNA-binding transcription factor activity
HK81_RS19600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HK81_RS19605	COG0473	3-isopropylmalate dehydrogenase activity
HK81_RS19610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HK81_RS19615	COG0066	3-isopropylmalate dehydratase activity
HK81_RS19625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HK81_RS19630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HK81_RS19635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HK81_RS19640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HK81_RS19645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HK81_RS19650	COG2967	ApaG domain
HK81_RS19655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HK81_RS19670	COG2966	Psort location CytoplasmicMembrane, score
HK81_RS19675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HK81_RS19685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HK81_RS19690	COG0142	geranyltranstransferase activity
HK81_RS19700	COG0039	L-malate dehydrogenase activity
HK81_RS19710	COG2358	TRAP transporter, solute receptor (TAXI family
HK81_RS19725	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HK81_RS19730	COG1178	ABC-type Fe3 transport system permease component
HK81_RS19735	COG4143	(ABC) transporter
HK81_RS19740	COG0163	prenyltransferase activity
HK81_RS19745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HK81_RS19750	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HK81_RS19755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HK81_RS19765	COG2105	PFAM AIG2 family protein
HK81_RS19775	COG0729	surface antigen
HK81_RS19780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HK81_RS19790	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HK81_RS19805	COG4181	ATPase activity
HK81_RS19825	COG0529	Catalyzes the synthesis of activated sulfate
HK81_RS19830	COG0471	metal ion transport
HK81_RS19830	COG3273	potassium ion transport
HK81_RS19835	COG2895	sulfate adenylyltransferase (ATP) activity
HK81_RS19840	COG0175	sulfate reduction
HK81_RS19845	COG1648	precorrin-2 dehydrogenase activity
HK81_RS19845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HK81_RS19850	COG0737	Belongs to the 5'-nucleotidase family
HK81_RS19860	COG0513	Belongs to the DEAD box helicase family
HK81_RS19865	COG2153	protein acetylation
HK81_RS19875	COG0545	Peptidyl-prolyl cis-trans isomerase
HK81_RS19885	COG0203	ribosomal protein L17
HK81_RS19890	COG0202	RNA polymerase activity
HK81_RS19900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HK81_RS19905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HK81_RS19910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HK81_RS19915	COG0201	protein transport
HK81_RS19920	COG0200	Binds to the 23S rRNA
HK81_RS19925	COG1841	ribosomal large subunit assembly
HK81_RS19940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HK81_RS19945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HK81_RS19950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HK81_RS19955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HK81_RS19960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HK81_RS19965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HK81_RS19970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HK81_RS19975	COG0255	Belongs to the universal ribosomal protein uL29 family
HK81_RS19985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HK81_RS19990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HK81_RS19995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HK81_RS20000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HK81_RS20010	COG0088	Forms part of the polypeptide exit tunnel
HK81_RS20015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HK81_RS20025	COG0254	rRNA binding
HK81_RS20030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HK81_RS20035	COG1609	Transcriptional regulator
HK81_RS20045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HK81_RS20050	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HK81_RS20065	COG2003	Belongs to the UPF0758 family
HK81_RS20095	COG1575	Belongs to the MenA family. Type 1 subfamily
HK81_RS20100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HK81_RS20105	COG3074	FtsZ-dependent cytokinesis
HK81_RS20110	COG1494	fructose-1,6-bisphosphatase
HK81_RS20135	COG0149	triose-phosphate isomerase activity
HK81_RS20140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HK81_RS20155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HK81_RS20180	COG1086	Polysaccharide biosynthesis protein
HK81_RS20245	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HK81_RS20255	COG1560	Kdo2-lipid A biosynthetic process
HK81_RS20260	COG0859	PFAM glycosyl transferase family 9
HK81_RS20265	COG1519	Transferase
HK81_RS20295	COG2030	dehydratase
HK81_RS20300	COG0110	maltose O-acetyltransferase activity
HK81_RS20320	COG3642	lipopolysaccharide core region biosynthetic process
HK81_RS20325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HK81_RS20330	COG0859	PFAM glycosyl transferase family 9
HK81_RS20335	COG0463	Glycosyl transferase, family 2
HK81_RS20350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HK81_RS20355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HK81_RS20370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HK81_RS20375	COG2003	Belongs to the UPF0758 family
HK81_RS20380	COG0840	transmembrane signaling receptor activity
HK81_RS20385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HK81_RS20390	COG1309	transcriptional regulator
HK81_RS20395	COG1560	Kdo2-lipid A biosynthetic process
HK81_RS20400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HK81_RS20405	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HK81_RS20410	COG1561	YicC-like family, N-terminal region
HK81_RS20420	COG2246	polysaccharide biosynthetic process
HK81_RS20440	COG2963	transposase activity
HK81_RS20470	COG5001	Diguanylate cyclase
HK81_RS20480	COG4608	Belongs to the ABC transporter superfamily
HK81_RS20485	COG0444	Belongs to the ABC transporter superfamily
HK81_RS20490	COG0747	negative chemotaxis
HK81_RS20495	COG4239	(ABC) transporter, permease
HK81_RS20500	COG4174	ABC transporter (Permease)
HK81_RS20520	COG0811	peptide transport
HK81_RS20525	COG0848	biopolymer transport protein
HK81_RS20540	COG0194	GDP metabolic process
HK81_RS20545	COG1758	RNA polymerase activity
HK81_RS20550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HK81_RS20555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HK81_RS20560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HK81_RS20570	COG2233	PERMEase
HK81_RS20590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HK81_RS20600	COG2183	response to ionizing radiation
HK81_RS20610	COG0596	Alpha beta hydrolase
HK81_RS20615	COG0316	Belongs to the HesB IscA family
HK81_RS20615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HK81_RS20620	COG0494	nUDIX hydrolase
HK81_RS20625	COG1218	3'(2'),5'-bisphosphate nucleotidase
HK81_RS20635	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HK81_RS20640	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HK81_RS20645	COG3156	type II secretion system protein K
HK81_RS20650	COG4795	General secretion pathway protein
HK81_RS20655	COG2165	general secretion pathway protein
HK81_RS20660	COG2165	general secretion pathway protein
HK81_RS20665	COG2165	general secretion pathway protein
HK81_RS20670	COG1459	type II secretion system
HK81_RS20675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HK81_RS20685	COG3031	protein transport across the cell outer membrane
HK81_RS20690	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HK81_RS20695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HK81_RS20700	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HK81_RS20710	COG0456	acetyltransferase
HK81_RS20715	COG1490	D-aminoacyl-tRNA deacylase activity
HK81_RS20720	COG1295	ribonuclease BN
HK81_RS20735	COG1217	gtp-binding protein TYPA
HK81_RS20740	COG0174	glutamine synthetase
HK81_RS20750	COG3852	Histidine kinase
HK81_RS20755	COG2204	response regulator
HK81_RS20765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HK81_RS20800	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HK81_RS20805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HK81_RS20805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HK81_RS20820	COG0084	hydrolase, TatD family'
HK81_RS20825	COG0805	protein transport
HK81_RS20830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HK81_RS20835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HK81_RS20840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HK81_RS20845	COG3165	ubiquinone biosynthetic process from chorismate
HK81_RS20850	COG2226	methyltransferase
HK81_RS20855	COG1322	Protein conserved in bacteria
HK81_RS20870	COG0628	permease
HK81_RS20920	COG2823	Periplasmic or secreted lipoprotein
HK81_RS20945	COG2081	HI0933 family
HK81_RS20955	COG1528	Iron-storage protein
HK81_RS20960	COG0589	response to stress
HK81_RS20975	COG0742	ribosomal rna small subunit methyltransferase
HK81_RS20980	COG5002	protein histidine kinase activity
HK81_RS20980	COG5001	Diguanylate cyclase
HK81_RS20985	COG1522	sequence-specific DNA binding
HK81_RS20990	COG0339	signal peptide processing
HK81_RS20995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HK81_RS21000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HK81_RS21005	COG0583	DNA-binding transcription factor activity
HK81_RS21010	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HK81_RS21015	COG0800	Aldolase
HK81_RS21020	COG2610	gluconate transmembrane transporter activity
HK81_RS21025	COG3265	gluconokinase activity
HK81_RS21030	COG0129	dihydroxy-acid dehydratase activity
HK81_RS21045	COG0583	DNA-binding transcription factor activity
HK81_RS21050	COG1609	Transcriptional regulator
HK81_RS21085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HK81_RS21090	COG0601	transmembrane transport
HK81_RS21095	COG0747	negative chemotaxis
HK81_RS21100	COG4172	Belongs to the ABC transporter superfamily
HK81_RS21155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK81_RS21160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HK81_RS21165	COG2960	long-chain fatty acid transporting porin activity
HK81_RS21170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HK81_RS21175	COG0583	DNA-binding transcription factor activity
HK81_RS21215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HK81_RS21220	COG1739	Uncharacterized protein family UPF0029
HK81_RS21225	COG1250	3-hydroxyacyl-CoA dehydrogenase
HK81_RS21225	COG1024	Enoyl-CoA hydratase
HK81_RS21230	COG0183	Belongs to the thiolase family
HK81_RS21235	COG0604	alcohol dehydrogenase
HK81_RS21250	COG0425	Belongs to the sulfur carrier protein TusA family
HK81_RS21260	COG2119	membrane
HK81_RS21265	COG0752	glycyl-tRNA synthetase alpha subunit
HK81_RS21270	COG0751	glycine-tRNA ligase activity
HK81_RS21275	COG0366	Alpha amylase catalytic
HK81_RS21280	COG3977	Valine--pyruvate aminotransferase
HK81_RS21285	COG0071	Belongs to the small heat shock protein (HSP20) family
HK81_RS21295	COG0187	DNA topoisomerase II activity
HK81_RS21300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HK81_RS21305	COG0592	DNA-directed DNA polymerase activity
HK81_RS21310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HK81_RS21325	COG1126	abc transporter atp-binding protein
HK81_RS21335	COG0594	ribonuclease P activity
HK81_RS21340	COG0706	membrane insertase activity
HK81_RS21345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HK81_RS21350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HK81_RS21355	COG0445	tRNA wobble uridine modification
HK81_RS21360	COG0357	Ribosomal RNA small subunit methyltransferase G
HK81_RS21365	COG1192	Involved in chromosome partitioning
HK81_RS21370	COG1475	DNA binding
HK81_RS21375	COG3312	ion transport
HK81_RS21380	COG0356	it plays a direct role in the translocation of protons across the membrane
HK81_RS21395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HK81_RS21400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HK81_RS21405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HK81_RS21410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HK81_RS21415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HK81_RS21420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HK81_RS21425	COG0765	amino acid transport
HK81_RS21430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HK81_RS21435	COG2814	Major facilitator Superfamily
HK81_RS21440	COG0583	DNA-binding transcription factor activity
HK81_RS21450	COG0129	dihydroxy-acid dehydratase activity
HK81_RS21455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HK81_RS21460	COG3978	acetolactate synthase activity
HK81_RS21470	COG0606	chelatase, subunit chli
HK81_RS21480	COG0204	Acyl-transferase
HK81_RS21485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HK81_RS21490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HK81_RS21500	COG3084	Protein conserved in bacteria
HK81_RS21505	COG4326	sporulation control protein
HK81_RS21510	COG1272	protein, Hemolysin III
HK81_RS21520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HK81_RS21525	COG0569	domain protein
HK81_RS21530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HK81_RS21530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HK81_RS21535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HK81_RS21540	COG0242	peptide deformylase activity
HK81_RS21550	COG0758	DNA mediated transformation
HK81_RS21555	COG2922	Belongs to the Smg family
HK81_RS21560	COG0551	DNA topoisomerase type I activity
HK81_RS21565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HK81_RS21570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HK81_RS21575	COG0009	L-threonylcarbamoyladenylate synthase
HK81_RS21580	COG0408	coproporphyrinogen oxidase activity
HK81_RS21585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HK81_RS21595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HK81_RS21645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HK81_RS21650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HK81_RS21660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HK81_RS21665	COG2104	thiamine diphosphate biosynthetic process
HK81_RS21670	COG2022	thiamine diphosphate biosynthetic process
HK81_RS21680	COG0006	proline dipeptidase activity
HK81_RS21680	COG0006	proline dipeptidase activity
HK81_RS21710	COG3220	belongs to the UPF0276 family
HK81_RS21720	COG0210	DNA helicase
HK81_RS21725	COG0405	Gamma-glutamyltransferase
HK81_RS21730	COG1280	lysine exporter protein (LysE YggA)
HK81_RS21740	COG2962	Rard protein
HK81_RS21745	COG0514	ATP-dependent DNA helicase (RecQ)
HK81_RS21755	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HK81_RS21760	COG0248	Ppx GppA phosphatase
HK81_RS21765	COG0513	Belongs to the DEAD box helicase family
HK81_RS21770	COG3118	belongs to the thioredoxin family
HK81_RS21785	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HK81_RS21790	COG0633	Ferredoxin
HK81_RS21835	COG3071	HemY protein
HK81_RS21840	COG2959	enzyme of heme biosynthesis
HK81_RS21845	COG1587	Uroporphyrinogen-III synthase
HK81_RS21850	COG0181	hydroxymethylbilane synthase activity
HK81_RS21855	COG3072	Adenylate cyclase
HK81_RS21860	COG1965	Belongs to the frataxin family
HK81_RS21870	COG0019	diaminopimelate decarboxylase activity
HK81_RS21875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HK81_RS21885	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HK81_RS21890	COG1011	Hydrolase
HK81_RS21895	COG2200	EAL domain
HK81_RS21895	COG2199	diguanylate cyclase activity
HK81_RS21895	COG3287	FIST C domain
HK81_RS21900	COG3148	PFAM DTW domain containing protein
HK81_RS21915	COG0561	phosphatase activity
HK81_RS21920	COG2267	carboxylic ester hydrolase activity
HK81_RS21925	COG1280	lysine exporter protein (LysE YggA)
HK81_RS21930	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HK81_RS21935	COG0640	Transcriptional regulator
HK81_RS21940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HK81_RS21990	COG2095	MarC family integral membrane protein
HK81_RS22000	COG0742	ribosomal rna small subunit methyltransferase
HK81_RS22005	COG0552	protein localization to endoplasmic reticulum
HK81_RS22010	COG2884	Cell division ATP-binding protein ftsE
HK81_RS22015	COG2177	Part of the ABC transporter FtsEX involved in
HK81_RS22025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HK81_RS22030	COG0705	Rhomboid family
HK81_RS22035	COG1580	Controls the rotational direction of flagella during chemotaxis
HK81_RS22040	COG3161	chorismate lyase activity
HK81_RS22045	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HK81_RS22050	COG2937	Belongs to the GPAT DAPAT family
HK81_RS22055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HK81_RS22060	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HK81_RS22065	COG0534	Mate efflux family protein
HK81_RS22070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HK81_RS22105	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HK81_RS22135	COG2003	Belongs to the UPF0758 family
HK81_RS22150	COG3339	Conserved Protein
HK81_RS22190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HK81_RS22195	COG4206	TonB-dependent receptor
HK81_RS22205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HK81_RS22260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HK81_RS22270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HK81_RS22310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HK81_RS22315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HK81_RS22320	COG0250	Participates in transcription elongation, termination and antitermination
HK81_RS22325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HK81_RS22330	COG0081	regulation of translation
HK81_RS22335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HK81_RS22340	COG0222	ribosome binding
HK81_RS22345	COG0085	RNA polymerase activity
HK81_RS22350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HK81_RS22355	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HK81_RS22360	COG2816	NAD+ diphosphatase activity
HK81_RS22375	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HK81_RS22380	COG1573	uracil-dna glycosylase
HK81_RS22385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HK81_RS22395	COG1253	flavin adenine dinucleotide binding
HK81_RS22410	COG0151	Belongs to the GarS family
HK81_RS22415	COG0138	bifunctional purine biosynthesis protein purh
HK81_RS22420	COG0789	Transcriptional regulator
HK81_RS22425	COG3710	Transcriptional regulator
HK81_RS22435	COG0531	amino acid
HK81_RS22440	COG1982	Orn Lys Arg decarboxylase major
HK81_RS22505	COG3706	GGDEF domain
HK81_RS22510	COG0488	(ABC) transporter
HK81_RS22515	COG2814	Major facilitator Superfamily
HK81_RS22520	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HK81_RS22525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HK81_RS22530	COG2264	protein methyltransferase activity
HK81_RS22535	COG0439	Biotin carboxylase
HK81_RS22540	COG0511	ligase activity, forming carbon-carbon bonds
HK81_RS22545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HK81_RS22550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HK81_RS22565	COG2814	Major facilitator Superfamily
HK81_RS22570	COG2198	Histidine kinase
HK81_RS22570	COG0784	Response regulator, receiver
HK81_RS22570	COG2205	protein histidine kinase activity
HK81_RS22590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HK81_RS22600	COG3263	regulation of cellular component size
HK81_RS22610	COG4232	protein-disulfide reductase activity
HK81_RS22615	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HK81_RS22620	COG1027	Aspartate ammonia-lyase
HK81_RS22625	COG3030	protein affecting phage T7 exclusion by the F plasmid
HK81_RS22630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HK81_RS22640	COG2205	protein histidine kinase activity
HK81_RS22645	COG0745	RESPONSE REGULATOR receiver
HK81_RS22650	COG3678	ATP-independent chaperone mediated protein folding
HK81_RS22660	COG0205	6-phosphofructokinase activity
HK81_RS22665	COG0534	Mate efflux family protein
HK81_RS22675	COG0459	protein refolding
HK81_RS22695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HK81_RS22700	COG1509	lysine 2,3-aminomutase activity
HK81_RS22705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HK81_RS22715	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HK81_RS22720	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HK81_RS22725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HK81_RS22730	COG1053	succinate dehydrogenase
HK81_RS22735	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HK81_RS22755	COG4942	peptidase
HK81_RS22760	COG1045	serine acetyltransferase
HK81_RS22765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HK81_RS22770	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HK81_RS22775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HK81_RS22780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HK81_RS22790	COG0840	transmembrane signaling receptor activity
HK81_RS22795	COG0471	metal ion transport
HK81_RS22800	COG0688	phosphatidylethanolamine metabolic process
HK81_RS22805	COG1162	GTPase activity
HK81_RS22810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HK81_RS22880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HK81_RS22885	COG0802	atpase or kinase
HK81_RS22895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HK81_RS22900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HK81_RS22910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HK81_RS22915	COG0330	HflC and HflK could
HK81_RS22920	COG0330	HflC and HflK could
HK81_RS22925	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HK81_RS22930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HK81_RS22935	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK81_RS22940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HK81_RS22940	COG1017	nitric oxide dioxygenase activity
HK81_RS22945	COG1959	2 iron, 2 sulfur cluster binding
HK81_RS22950	COG0557	exoribonuclease II activity
HK81_RS22955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HK81_RS22960	COG0546	phosphoglycolate phosphatase activity
HK81_RS22965	COG0180	Tryptophanyl-tRNA synthetase
HK81_RS22980	COG0512	Glutamine amidotransferase of anthranilate synthase
HK81_RS22985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HK81_RS22995	COG1012	belongs to the aldehyde dehydrogenase family
HK81_RS23005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HK81_RS23010	COG3954	Phosphoribulokinase
HK81_RS23015	COG3089	Belongs to the UPF0270 family
HK81_RS23020	COG0429	hydrolase of the alpha beta-hydrolase fold
HK81_RS23030	COG0488	(ABC) transporter
HK81_RS23035	COG2249	NAD(P)H dehydrogenase (quinone) activity
HK81_RS23050	COG1047	Peptidyl-prolyl cis-trans
HK81_RS23055	COG1446	asparaginase
HK81_RS23060	COG2900	Belongs to the SlyX family
HK81_RS23070	COG0545	Peptidyl-prolyl cis-trans isomerase
HK81_RS23075	COG2964	Protein conserved in bacteria
HK81_RS23080	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HK81_RS23085	COG2923	Belongs to the DsrF TusC family
HK81_RS23090	COG2168	tRNA wobble position uridine thiolation
HK81_RS23100	COG0049	tRNA binding
HK81_RS23105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HK81_RS23110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HK81_RS23115	COG2906	2 iron, 2 sulfur cluster binding
HK81_RS23125	COG0281	malic enzyme
HK81_RS23135	COG0626	cystathionine gamma-synthase activity
HK81_RS23140	COG0527	aspartate kinase activity
HK81_RS23140	COG0460	homoserine dehydrogenase
HK81_RS23145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HK81_RS23155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HK81_RS23160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HK81_RS23165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HK81_RS23170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HK81_RS23175	COG0137	argininosuccinate synthase activity
HK81_RS23180	COG0165	Argininosuccinate lyase
HK81_RS23180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HK81_RS23190	COG0678	peroxiredoxin activity
HK81_RS23190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HK81_RS23200	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HK81_RS23230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HK81_RS23235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HK81_RS23245	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HK81_RS23250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HK81_RS23255	COG0360	Binds together with S18 to 16S ribosomal RNA
HK81_RS23260	COG2965	DNA replication, synthesis of RNA primer
HK81_RS23270	COG0359	binds to the 23S rRNA
HK81_RS23285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HK81_RS23295	COG0432	Pfam Uncharacterised protein family UPF0047
HK81_RS23300	COG0166	Belongs to the GPI family
HK81_RS23310	COG0735	belongs to the Fur family
HK81_RS23315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HK81_RS23335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HK81_RS23340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HK81_RS23345	COG0175	sulfate reduction
HK81_RS23405	COG0297	glycogen (starch) synthase activity
HK81_RS23405	COG0438	transferase activity, transferring glycosyl groups