locus-tag	class	description
CFH89_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CFH89_RS00010	COG0592	DNA-directed DNA polymerase activity
CFH89_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFH89_RS00020	COG0187	DNA topoisomerase II activity
CFH89_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
CFH89_RS00045	COG3977	Valine--pyruvate aminotransferase
CFH89_RS00050	COG0366	Alpha amylase catalytic
CFH89_RS00055	COG0751	glycine-tRNA ligase activity
CFH89_RS00060	COG0752	glycyl-tRNA synthetase alpha subunit
CFH89_RS00065	COG2119	membrane
CFH89_RS00075	COG0425	Belongs to the sulfur carrier protein TusA family
CFH89_RS00090	COG0604	alcohol dehydrogenase
CFH89_RS00095	COG0183	Belongs to the thiolase family
CFH89_RS00100	COG1024	Enoyl-CoA hydratase
CFH89_RS00100	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFH89_RS00105	COG1739	Uncharacterized protein family UPF0029
CFH89_RS00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFH89_RS00160	COG0583	DNA-binding transcription factor activity
CFH89_RS00165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CFH89_RS00170	COG2960	long-chain fatty acid transporting porin activity
CFH89_RS00180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFH89_RS00185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFH89_RS00250	COG4172	Belongs to the ABC transporter superfamily
CFH89_RS00255	COG0747	negative chemotaxis
CFH89_RS00260	COG0601	transmembrane transport
CFH89_RS00265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFH89_RS00310	COG0583	DNA-binding transcription factor activity
CFH89_RS00330	COG3265	gluconokinase activity
CFH89_RS00335	COG2610	gluconate transmembrane transporter activity
CFH89_RS00340	COG0800	Aldolase
CFH89_RS00345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CFH89_RS00350	COG0583	DNA-binding transcription factor activity
CFH89_RS00355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFH89_RS00360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CFH89_RS00370	COG0339	signal peptide processing
CFH89_RS00375	COG1522	sequence-specific DNA binding
CFH89_RS00385	COG0742	ribosomal rna small subunit methyltransferase
CFH89_RS00395	COG0697	spore germination
CFH89_RS00400	COG0589	response to stress
CFH89_RS00405	COG1528	Iron-storage protein
CFH89_RS00415	COG2081	HI0933 family
CFH89_RS00425	COG2823	Periplasmic or secreted lipoprotein
CFH89_RS00475	COG0628	permease
CFH89_RS00490	COG1322	Protein conserved in bacteria
CFH89_RS00495	COG2226	methyltransferase
CFH89_RS00500	COG3165	ubiquinone biosynthetic process from chorismate
CFH89_RS00505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CFH89_RS00510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFH89_RS00515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFH89_RS00520	COG0805	protein transport
CFH89_RS00530	COG0084	hydrolase, TatD family'
CFH89_RS00555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFH89_RS00555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFH89_RS00565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CFH89_RS00600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CFH89_RS00610	COG2204	response regulator
CFH89_RS00615	COG3852	Histidine kinase
CFH89_RS00625	COG0174	glutamine synthetase
CFH89_RS00635	COG1217	gtp-binding protein TYPA
CFH89_RS00650	COG1295	ribonuclease BN
CFH89_RS00655	COG1490	D-aminoacyl-tRNA deacylase activity
CFH89_RS00660	COG0456	acetyltransferase
CFH89_RS00670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CFH89_RS00675	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CFH89_RS00680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CFH89_RS00685	COG3031	protein transport across the cell outer membrane
CFH89_RS00695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFH89_RS00700	COG1459	type II secretion system
CFH89_RS00705	COG2165	general secretion pathway protein
CFH89_RS00710	COG2165	general secretion pathway protein
CFH89_RS00715	COG2165	general secretion pathway protein
CFH89_RS00720	COG4795	General secretion pathway protein
CFH89_RS00725	COG3156	type II secretion system protein K
CFH89_RS00730	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CFH89_RS00735	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CFH89_RS00745	COG1218	3'(2'),5'-bisphosphate nucleotidase
CFH89_RS00750	COG0494	nUDIX hydrolase
CFH89_RS00755	COG0316	Belongs to the HesB IscA family
CFH89_RS00755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CFH89_RS00760	COG1040	competence protein
CFH89_RS00765	COG0596	Alpha beta hydrolase
CFH89_RS00775	COG2183	response to ionizing radiation
CFH89_RS00785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFH89_RS00805	COG2233	PERMEase
CFH89_RS00820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFH89_RS00825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFH89_RS00830	COG1758	RNA polymerase activity
CFH89_RS00835	COG0194	GDP metabolic process
CFH89_RS00850	COG0848	biopolymer transport protein
CFH89_RS00855	COG0811	peptide transport
CFH89_RS00890	COG0747	negative chemotaxis
CFH89_RS00895	COG0444	Belongs to the ABC transporter superfamily
CFH89_RS00900	COG4608	Belongs to the ABC transporter superfamily
CFH89_RS00910	COG1561	YicC-like family, N-terminal region
CFH89_RS00915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CFH89_RS00920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CFH89_RS00930	COG1309	transcriptional regulator
CFH89_RS00935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CFH89_RS00950	COG2003	Belongs to the UPF0758 family
CFH89_RS00955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFH89_RS00970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFH89_RS00985	COG0438	transferase activity, transferring glycosyl groups
CFH89_RS00990	COG0463	Glycosyl transferase, family 2
CFH89_RS00995	COG0859	PFAM glycosyl transferase family 9
CFH89_RS01000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CFH89_RS01005	COG3642	lipopolysaccharide core region biosynthetic process
CFH89_RS01025	COG0110	maltose O-acetyltransferase activity
CFH89_RS01030	COG2030	dehydratase
CFH89_RS01050	COG0438	transferase activity, transferring glycosyl groups
CFH89_RS01050	COG0297	glycogen (starch) synthase activity
CFH89_RS01060	COG1519	Transferase
CFH89_RS01065	COG0859	PFAM glycosyl transferase family 9
CFH89_RS01070	COG1560	Kdo2-lipid A biosynthetic process
CFH89_RS01080	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFH89_RS01130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFH89_RS01140	COG0110	maltose O-acetyltransferase activity
CFH89_RS01145	COG1215	transferase activity, transferring glycosyl groups
CFH89_RS01165	COG0438	transferase activity, transferring glycosyl groups
CFH89_RS01185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFH89_RS01205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CFH89_RS01210	COG0149	triose-phosphate isomerase activity
CFH89_RS01235	COG1494	fructose-1,6-bisphosphatase
CFH89_RS01245	COG3074	FtsZ-dependent cytokinesis
CFH89_RS01250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CFH89_RS01255	COG1575	Belongs to the MenA family. Type 1 subfamily
CFH89_RS01285	COG2003	Belongs to the UPF0758 family
CFH89_RS01300	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CFH89_RS01305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CFH89_RS01315	COG1609	Transcriptional regulator
CFH89_RS01330	COG0254	rRNA binding
CFH89_RS01340	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CFH89_RS01345	COG0088	Forms part of the polypeptide exit tunnel
CFH89_RS01355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CFH89_RS01360	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CFH89_RS01365	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CFH89_RS01370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CFH89_RS01380	COG0255	Belongs to the universal ribosomal protein uL29 family
CFH89_RS01385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CFH89_RS01390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CFH89_RS01395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CFH89_RS01400	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CFH89_RS01405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFH89_RS01410	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CFH89_RS01415	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CFH89_RS01430	COG1841	ribosomal large subunit assembly
CFH89_RS01435	COG0200	Binds to the 23S rRNA
CFH89_RS01440	COG0201	protein transport
CFH89_RS01445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CFH89_RS01450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CFH89_RS01455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CFH89_RS01465	COG0202	RNA polymerase activity
CFH89_RS01470	COG0203	ribosomal protein L17
CFH89_RS01480	COG0545	Peptidyl-prolyl cis-trans isomerase
CFH89_RS01490	COG2153	protein acetylation
CFH89_RS01495	COG0513	Belongs to the DEAD box helicase family
CFH89_RS01505	COG0737	Belongs to the 5'-nucleotidase family
CFH89_RS01510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CFH89_RS01510	COG1648	precorrin-2 dehydrogenase activity
CFH89_RS01515	COG0175	sulfate reduction
CFH89_RS01520	COG2895	sulfate adenylyltransferase (ATP) activity
CFH89_RS01530	COG0471	metal ion transport
CFH89_RS01530	COG3273	potassium ion transport
CFH89_RS01535	COG0529	Catalyzes the synthesis of activated sulfate
CFH89_RS01555	COG4181	ATPase activity
CFH89_RS01570	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CFH89_RS01580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFH89_RS01595	COG2105	PFAM AIG2 family protein
CFH89_RS01605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CFH89_RS01610	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CFH89_RS01620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CFH89_RS01625	COG0163	prenyltransferase activity
CFH89_RS01630	COG4143	(ABC) transporter
CFH89_RS01635	COG1178	ABC-type Fe3 transport system permease component
CFH89_RS01640	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CFH89_RS01660	COG2358	TRAP transporter, solute receptor (TAXI family
CFH89_RS01675	COG0039	L-malate dehydrogenase activity
CFH89_RS01685	COG0142	geranyltranstransferase activity
CFH89_RS01690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CFH89_RS01700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CFH89_RS01705	COG2966	Psort location CytoplasmicMembrane, score
CFH89_RS01720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CFH89_RS01725	COG2967	ApaG domain
CFH89_RS01730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CFH89_RS01735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CFH89_RS01740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFH89_RS01745	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CFH89_RS01750	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CFH89_RS01760	COG0066	3-isopropylmalate dehydratase activity
CFH89_RS01765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFH89_RS01770	COG0473	3-isopropylmalate dehydrogenase activity
CFH89_RS01775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFH89_RS01800	COG0583	DNA-binding transcription factor activity
CFH89_RS01805	COG1022	Amp-dependent synthetase and ligase
CFH89_RS01810	COG0028	Belongs to the TPP enzyme family
CFH89_RS01815	COG0440	acetolactate synthase activity
CFH89_RS01830	COG0469	pyruvate kinase activity
CFH89_RS01840	COG1349	DNA-binding transcription factor activity
CFH89_RS01845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFH89_RS01860	COG5002	protein histidine kinase activity
CFH89_RS01865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFH89_RS01870	COG3722	fumarate hydratase activity
CFH89_RS01875	COG0246	Mannitol dehydrogenase
CFH89_RS01880	COG2213	PTS system mannitol-specific
CFH89_RS01880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFH89_RS01915	COG1464	Belongs to the NlpA lipoprotein family
CFH89_RS01925	COG3339	Conserved Protein
CFH89_RS01935	COG2801	Transposase and inactivated derivatives
CFH89_RS02035	COG0494	nUDIX hydrolase
CFH89_RS02045	COG1566	PFAM secretion protein HlyD family protein
CFH89_RS02180	COG0358	DNA primase activity
CFH89_RS02185	COG1610	YqeY-like protein
CFH89_RS02190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CFH89_RS02195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CFH89_RS02200	COG0596	Alpha beta hydrolase
CFH89_RS02210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CFH89_RS02220	COG1968	undecaprenyl-diphosphatase activity
CFH89_RS02225	COG0617	tRNA 3'-terminal CCA addition
CFH89_RS02230	COG3267	Type II secretory pathway component ExeA
CFH89_RS02230	COG3409	Peptidoglycan-binding domain 1 protein
CFH89_RS02240	COG4991	sh3 domain protein
CFH89_RS02245	COG0306	phosphate transporter
CFH89_RS02250	COG1392	Phosphate transport regulator
CFH89_RS02255	COG3025	triphosphatase activity
CFH89_RS02270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CFH89_RS02275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CFH89_RS02275	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CFH89_RS02280	COG1538	Outer membrane efflux protein
CFH89_RS02285	COG0494	nUDIX hydrolase
CFH89_RS02290	COG3151	Protein conserved in bacteria
CFH89_RS02300	COG3150	esterase
CFH89_RS02310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CFH89_RS02315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFH89_RS02325	COG3105	Protein conserved in bacteria
CFH89_RS02335	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CFH89_RS02345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CFH89_RS02350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CFH89_RS02355	COG0723	plastoquinol--plastocyanin reductase activity
CFH89_RS02360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CFH89_RS02365	COG2857	Cytochrome c1
CFH89_RS02370	COG0625	glutathione transferase activity
CFH89_RS02375	COG2969	positive regulation of protein catabolic process
CFH89_RS02380	COG2823	Periplasmic or secreted lipoprotein
CFH89_RS02385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CFH89_RS02390	COG0792	nuclease activity
CFH89_RS02400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CFH89_RS02415	COG0275	rRNA processing
CFH89_RS02420	COG3116	cell division
CFH89_RS02425	COG0768	penicillin binding
CFH89_RS02430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFH89_RS02435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFH89_RS02440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFH89_RS02445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CFH89_RS02450	COG0772	Belongs to the SEDS family
CFH89_RS02455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFH89_RS02460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CFH89_RS02465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CFH89_RS02475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CFH89_RS02480	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CFH89_RS02490	COG0653	protein targeting
CFH89_RS02495	COG0494	nUDIX hydrolase
CFH89_RS02500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CFH89_RS02505	COG0505	Belongs to the CarA family
CFH89_RS02510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFH89_RS02525	COG0730	response to heat
CFH89_RS02530	COG0583	DNA-binding transcription factor activity
CFH89_RS02535	COG2860	membrane
CFH89_RS02540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFH89_RS02550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CFH89_RS02565	COG0067	glutamate synthase
CFH89_RS02565	COG0069	glutamate synthase activity
CFH89_RS02565	COG0070	glutamate synthase
CFH89_RS02575	COG0067	glutamate synthase
CFH89_RS02575	COG0069	glutamate synthase activity
CFH89_RS02575	COG0070	glutamate synthase
CFH89_RS02580	COG1242	4 iron, 4 sulfur cluster binding
CFH89_RS02585	COG2203	Gaf domain
CFH89_RS02585	COG3706	GGDEF domain
CFH89_RS02585	COG5001	Diguanylate cyclase
CFH89_RS02585	COG4251	negative regulation of phosphorylation
CFH89_RS02590	COG2198	Histidine kinase
CFH89_RS02590	COG0784	Response regulator, receiver
CFH89_RS02590	COG5002	protein histidine kinase activity
CFH89_RS02600	COG0745	RESPONSE REGULATOR receiver
CFH89_RS02615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CFH89_RS02630	COG0083	homoserine kinase activity
CFH89_RS02635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CFH89_RS02640	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CFH89_RS02645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CFH89_RS02655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CFH89_RS02670	COG1115	amino acid carrier protein
CFH89_RS02675	COG3022	response to hydroperoxide
CFH89_RS02680	COG0513	Belongs to the DEAD box helicase family
CFH89_RS02685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CFH89_RS02695	COG0716	FMN binding
CFH89_RS02700	COG4974	Belongs to the 'phage' integrase family
CFH89_RS02705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CFH89_RS02710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CFH89_RS02720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CFH89_RS02735	COG0667	Aldo Keto reductase
CFH89_RS02755	COG0494	nUDIX hydrolase
CFH89_RS02770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CFH89_RS02775	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CFH89_RS02785	COG1283	sodium-dependent phosphate transmembrane transporter activity
CFH89_RS02790	COG0583	DNA-binding transcription factor activity
CFH89_RS02800	COG0640	Transcriptional regulator
CFH89_RS02810	COG0268	Binds directly to 16S ribosomal RNA
CFH89_RS02815	COG0728	peptidoglycan biosynthetic process
CFH89_RS02820	COG0196	riboflavin kinase activity
CFH89_RS02825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CFH89_RS02830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CFH89_RS02835	COG1047	Peptidyl-prolyl cis-trans
CFH89_RS02840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CFH89_RS02845	COG3279	Response regulator of the LytR AlgR family
CFH89_RS02850	COG3275	phosphorelay sensor kinase activity
CFH89_RS02855	COG1966	Carbon starvation protein
CFH89_RS02870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CFH89_RS02875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CFH89_RS02880	COG1472	Belongs to the glycosyl hydrolase 3 family
CFH89_RS02885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CFH89_RS02895	COG0739	heme binding
CFH89_RS02910	COG0488	(ABC) transporter
CFH89_RS02920	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CFH89_RS02925	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CFH89_RS02930	COG1605	Chorismate mutase
CFH89_RS02930	COG0077	Prephenate dehydratase
CFH89_RS02935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CFH89_RS02940	COG0741	lytic transglycosylase activity
CFH89_RS02945	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFH89_RS02960	COG0542	response to heat
CFH89_RS03020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CFH89_RS03025	COG0826	peptidase U32
CFH89_RS03030	COG2974	May be involved in recombination
CFH89_RS03040	COG0745	RESPONSE REGULATOR receiver
CFH89_RS03045	COG5002	protein histidine kinase activity
CFH89_RS03055	COG0248	Ppx GppA phosphatase
CFH89_RS03060	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CFH89_RS03070	COG0581	inorganic phosphate transmembrane transporter activity
CFH89_RS03075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFH89_RS03080	COG0704	Plays a role in the regulation of phosphate uptake
CFH89_RS03090	COG3142	Participates in the control of copper homeostasis
CFH89_RS03100	COG0450	alkyl hydroperoxide reductase
CFH89_RS03105	COG0583	DNA-binding transcription factor activity
CFH89_RS03115	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CFH89_RS03125	COG0517	IMP dehydrogenase activity
CFH89_RS03140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CFH89_RS03145	COG0343	queuine tRNA-ribosyltransferase activity
CFH89_RS03150	COG1862	Preprotein translocase
CFH89_RS03155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFH89_RS03160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFH89_RS03170	COG0483	inositol monophosphate 1-phosphatase activity
CFH89_RS03185	COG1104	cysteine desulfurase activity
CFH89_RS03190	COG0822	iron-sulfur transferase activity
CFH89_RS03200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CFH89_RS03205	COG0443	Heat shock 70 kDa protein
CFH89_RS03210	COG0633	Ferredoxin
CFH89_RS03215	COG2975	iron-sulfur cluster assembly
CFH89_RS03220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CFH89_RS03225	COG0105	UTP biosynthetic process
CFH89_RS03230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CFH89_RS03245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CFH89_RS03250	COG0124	histidyl-tRNA synthetase
CFH89_RS03255	COG2976	Protein conserved in bacteria
CFH89_RS03260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFH89_RS03265	COG1160	GTP binding
CFH89_RS03280	COG1570	exodeoxyribonuclease VII activity
CFH89_RS03290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFH89_RS03290	COG0519	Catalyzes the synthesis of GMP from XMP
CFH89_RS03295	COG1757	Na H antiporter
CFH89_RS03305	COG1584	GPR1 FUN34 yaaH family protein
CFH89_RS03315	COG1115	amino acid carrier protein
CFH89_RS03350	COG2873	o-acetylhomoserine
CFH89_RS03355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFH89_RS03375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFH89_RS03375	COG3153	acetyltransferase
CFH89_RS03380	COG0583	DNA-binding transcription factor activity
CFH89_RS03400	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CFH89_RS03405	COG2867	negative regulation of translational initiation
CFH89_RS03410	COG2914	Belongs to the UPF0125 (RnfH) family
CFH89_RS03415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFH89_RS03420	COG0497	DNA recombination
CFH89_RS03430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFH89_RS03435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CFH89_RS03445	COG0443	Heat shock 70 kDa protein
CFH89_RS03450	COG0484	heat shock protein binding
CFH89_RS03490	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CFH89_RS03505	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CFH89_RS03510	COG0047	phosphoribosylformylglycinamidine synthase activity
CFH89_RS03510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFH89_RS03535	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFH89_RS03540	COG2252	PERMEase
CFH89_RS03545	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CFH89_RS03550	COG1073	alpha beta
CFH89_RS03560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CFH89_RS03565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CFH89_RS03570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CFH89_RS03575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFH89_RS03575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFH89_RS03595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFH89_RS03600	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CFH89_RS03605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CFH89_RS03610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CFH89_RS03615	COG0142	geranyltranstransferase activity
CFH89_RS03620	COG1722	exodeoxyribonuclease VII activity
CFH89_RS03625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CFH89_RS03630	COG2885	chlorophyll binding
CFH89_RS03635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFH89_RS03635	COG0301	tRNA thio-modification
CFH89_RS03640	COG0583	DNA-binding transcription factor activity
CFH89_RS03650	COG2363	Small membrane protein
CFH89_RS03655	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CFH89_RS03670	COG1611	Belongs to the LOG family
CFH89_RS03685	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CFH89_RS03685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CFH89_RS03695	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CFH89_RS03700	COG1464	Belongs to the NlpA lipoprotein family
CFH89_RS03705	COG2011	ABC-type metal ion transport system permease component
CFH89_RS03710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFH89_RS03720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CFH89_RS03730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFH89_RS03730	COG1263	PTS System
CFH89_RS03735	COG0366	Alpha amylase catalytic
CFH89_RS03750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFH89_RS03755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFH89_RS03760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CFH89_RS03765	COG0321	lipoyl(octanoyl) transferase activity
CFH89_RS03770	COG2921	Belongs to the UPF0250 family
CFH89_RS03775	COG1686	Belongs to the peptidase S11 family
CFH89_RS03780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CFH89_RS03785	COG0772	Belongs to the SEDS family
CFH89_RS03790	COG0768	penicillin binding
CFH89_RS03795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CFH89_RS03800	COG0799	negative regulation of ribosome biogenesis
CFH89_RS03805	COG1466	dna polymerase III delta subunit
CFH89_RS03810	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CFH89_RS03815	COG0495	leucyl-tRNA aminoacylation
CFH89_RS03820	COG2888	peptidyl-tyrosine sulfation
CFH89_RS03825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CFH89_RS03830	COG4535	Mg2 and Co2 transporter CorC
CFH89_RS03835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CFH89_RS03840	COG1702	phosphate starvation-inducible protein PhoH
CFH89_RS03845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFH89_RS03970	COG0012	GTP binding
CFH89_RS03975	COG0193	aminoacyl-tRNA hydrolase activity
CFH89_RS03980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CFH89_RS03985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CFH89_RS03990	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CFH89_RS03995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CFH89_RS04000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CFH89_RS04005	COG2890	protein-(glutamine-N5) methyltransferase activity
CFH89_RS04010	COG3094	Invasion gene expression up-regulator, SirB
CFH89_RS04015	COG2912	Transglutaminase-like superfamily
CFH89_RS04020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CFH89_RS04025	COG0737	Belongs to the 5'-nucleotidase family
CFH89_RS04035	COG1187	pseudouridine synthase activity
CFH89_RS04040	COG2840	Smr protein MutS2
CFH89_RS04080	COG2608	mercury ion transmembrane transporter activity
CFH89_RS04080	COG2217	Heavy metal translocating P-type atpase
CFH89_RS04095	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CFH89_RS04100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFH89_RS04160	COG0835	chemotaxis
CFH89_RS04160	COG0784	Response regulator, receiver
CFH89_RS04165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CFH89_RS04170	COG1815	bacterial-type flagellum-dependent cell motility
CFH89_RS04175	COG1558	bacterial-type flagellum-dependent cell motility
CFH89_RS04185	COG1749	Flagellar hook protein flgE
CFH89_RS04195	COG4787	bacterial-type flagellum-dependent cell motility
CFH89_RS04205	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CFH89_RS04210	COG1706	bacterial-type flagellum-dependent cell motility
CFH89_RS04215	COG3951	Flagellar rod assembly protein muramidase FlgJ
CFH89_RS04215	COG1705	Flagellar rod assembly protein muramidase FlgJ
CFH89_RS04225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFH89_RS04235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFH89_RS04245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFH89_RS04250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFH89_RS04260	COG2190	(PTS) system
CFH89_RS04265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFH89_RS04270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFH89_RS04280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFH89_RS04285	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CFH89_RS04290	COG3115	cell septum assembly
CFH89_RS04295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CFH89_RS04325	COG0330	HflC and HflK could
CFH89_RS04330	COG3118	belongs to the thioredoxin family
CFH89_RS04340	COG0300	oxidoreductase activity
CFH89_RS04345	COG1090	epimerase
CFH89_RS04375	COG0622	Phosphoesterase
CFH89_RS04395	COG3710	Transcriptional regulator
CFH89_RS04400	COG0326	Molecular chaperone. Has ATPase activity
CFH89_RS04405	COG0563	adenylate kinase activity
CFH89_RS04410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CFH89_RS04415	COG3104	oligopeptide transport
CFH89_RS04420	COG0250	Participates in transcription elongation, termination and antitermination
CFH89_RS04425	COG0367	asparagine synthase
CFH89_RS04430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CFH89_RS04430	COG4651	solute:proton antiporter activity
CFH89_RS04435	COG1846	Transcriptional regulator
CFH89_RS04435	COG1940	carbohydrate kinase activity
CFH89_RS04440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CFH89_RS04450	COG1263	PTS System
CFH89_RS04450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFH89_RS04455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFH89_RS04460	COG0735	belongs to the Fur family
CFH89_RS04480	COG0596	Alpha beta hydrolase
CFH89_RS04485	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CFH89_RS04490	COG0033	Phosphoglucomutase
CFH89_RS04500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CFH89_RS04515	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CFH89_RS04520	COG1053	succinate dehydrogenase
CFH89_RS04525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFH89_RS04530	COG0567	Dehydrogenase, E1 component
CFH89_RS04535	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFH89_RS04540	COG0045	succinate-CoA ligase (ADP-forming) activity
CFH89_RS04550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFH89_RS04555	COG1121	(ABC) transporter
CFH89_RS04560	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CFH89_RS04565	COG4977	sequence-specific DNA binding
CFH89_RS04580	COG1918	ferrous iron import across plasma membrane
CFH89_RS04600	COG0018	arginyl-trna synthetase
CFH89_RS04610	COG3102	Protein conserved in bacteria
CFH89_RS04615	COG0788	formyltetrahydrofolate deformylase activity
CFH89_RS04625	COG1214	PFAM Peptidase M22, glycoprotease
CFH89_RS04640	COG2267	carboxylic ester hydrolase activity
CFH89_RS04650	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CFH89_RS04655	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CFH89_RS04660	COG2894	cell division
CFH89_RS04665	COG0850	regulation of cytokinetic process
CFH89_RS04670	COG3100	YcgL domain-containing protein
CFH89_RS04675	COG2951	lytic endotransglycosylase activity
CFH89_RS04680	COG0583	DNA-binding transcription factor activity
CFH89_RS04685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFH89_RS04690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CFH89_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
CFH89_RS04720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFH89_RS04745	COG2986	histidine ammonia-lyase
CFH89_RS04750	COG1216	Glycosyl transferase, family 2
CFH89_RS04755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFH89_RS04770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFH89_RS04775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFH89_RS04810	COG1253	flavin adenine dinucleotide binding
CFH89_RS04815	COG0513	Belongs to the DEAD box helicase family
CFH89_RS04820	COG0569	domain protein
CFH89_RS04845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CFH89_RS04850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CFH89_RS04855	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CFH89_RS04860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CFH89_RS04870	COG2204	response regulator
CFH89_RS04880	COG0544	peptidyl-prolyl cis-trans isomerase activity
CFH89_RS04890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CFH89_RS04895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CFH89_RS04900	COG0776	regulation of translation
CFH89_RS04905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFH89_RS04910	COG1555	photosystem II stabilization
CFH89_RS04925	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CFH89_RS04930	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CFH89_RS04935	COG0436	Aminotransferase
CFH89_RS04940	COG1169	isochorismate synthase
CFH89_RS04945	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CFH89_RS04950	COG0596	Alpha beta hydrolase
CFH89_RS04955	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CFH89_RS04975	COG2855	membrane
CFH89_RS04980	COG0477	Major facilitator Superfamily
CFH89_RS05030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFH89_RS05060	COG1522	sequence-specific DNA binding
CFH89_RS05070	COG1946	Acyl-CoA thioesterase
CFH89_RS05075	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CFH89_RS05090	COG2199	diguanylate cyclase activity
CFH89_RS05125	COG1061	Type III restriction enzyme res subunit
CFH89_RS05170	COG0515	serine threonine protein kinase
CFH89_RS05170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CFH89_RS05225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFH89_RS05230	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CFH89_RS05235	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CFH89_RS05245	COG0516	GMP reductase activity
CFH89_RS05245	COG0517	IMP dehydrogenase activity
CFH89_RS05275	COG0537	adenosine 5'-monophosphoramidase activity
CFH89_RS05300	COG3150	esterase
CFH89_RS05310	COG1252	NADH dehydrogenase
CFH89_RS05325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CFH89_RS05335	COG4591	ABC-type transport system involved in lipoprotein release permease component
CFH89_RS05340	COG1136	(ABC) transporter
CFH89_RS05355	COG0658	competence protein
CFH89_RS05355	COG2333	competence protein COMEC
CFH89_RS05360	COG1132	(ABC) transporter
CFH89_RS05365	COG1663	tetraacyldisaccharide 4'-kinase activity
CFH89_RS05375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CFH89_RS05380	COG2719	SpoVR family
CFH89_RS05385	COG2718	Belongs to the UPF0229 family
CFH89_RS05390	COG2766	serine protein kinase
CFH89_RS05400	COG3013	Belongs to the UPF0304 family
CFH89_RS05410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CFH89_RS05420	COG1882	Formate acetyltransferase
CFH89_RS05465	COG0708	Exodeoxyribonuclease III
CFH89_RS05475	COG3923	Primosomal replication protein n
CFH89_RS05480	COG0730	response to heat
CFH89_RS05485	COG1199	ATP-dependent helicase activity
CFH89_RS05495	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CFH89_RS05500	COG1187	pseudouridine synthase activity
CFH89_RS05510	COG1278	Cold shock
CFH89_RS05515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CFH89_RS05530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CFH89_RS05535	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CFH89_RS05540	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CFH89_RS05550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CFH89_RS05560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFH89_RS05565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CFH89_RS05570	COG0297	glycogen (starch) synthase activity
CFH89_RS05590	COG3070	regulator of competence-specific genes
CFH89_RS05595	COG1609	Transcriptional regulator
CFH89_RS05600	COG3381	protein complex oligomerization
CFH89_RS05605	COG0745	RESPONSE REGULATOR receiver
CFH89_RS05610	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CFH89_RS05615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFH89_RS05620	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CFH89_RS05625	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CFH89_RS05630	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CFH89_RS05650	COG4067	protein conserved in archaea
CFH89_RS05650	COG0189	ligase activity
CFH89_RS05660	COG0500	methyltransferase
CFH89_RS05665	COG4106	trans-aconitate 2-methyltransferase activity
CFH89_RS05670	COG1801	Protein of unknown function DUF72
CFH89_RS05675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CFH89_RS05680	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CFH89_RS05685	COG0840	transmembrane signaling receptor activity
CFH89_RS05690	COG0632	four-way junction helicase activity
CFH89_RS05695	COG2255	four-way junction helicase activity
CFH89_RS05700	COG1271	oxidase subunit
CFH89_RS05705	COG1294	oxidase, subunit
CFH89_RS05710	COG4890	Cyd operon protein YbgT
CFH89_RS05720	COG0824	Thioesterase
CFH89_RS05725	COG0811	peptide transport
CFH89_RS05740	COG0823	Involved in the tonB-independent uptake of proteins
CFH89_RS05745	COG2885	chlorophyll binding
CFH89_RS05750	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CFH89_RS05755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CFH89_RS05765	COG3766	membrane
CFH89_RS05775	COG0754	glutathionylspermidine amidase activity
CFH89_RS05785	COG5002	protein histidine kinase activity
CFH89_RS05785	COG0784	Response regulator, receiver
CFH89_RS05790	COG2801	Transposase and inactivated derivatives
CFH89_RS05805	COG0840	transmembrane signaling receptor activity
CFH89_RS05820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFH89_RS05825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFH89_RS05855	COG3568	Endonuclease Exonuclease Phosphatase
CFH89_RS05870	COG0583	DNA-binding transcription factor activity
CFH89_RS05880	COG0686	Belongs to the AlaDH PNT family
CFH89_RS05895	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CFH89_RS05905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CFH89_RS05920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CFH89_RS05925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFH89_RS05930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CFH89_RS05935	COG0156	8-amino-7-oxononanoate synthase activity
CFH89_RS05945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CFH89_RS05955	COG0501	Belongs to the peptidase M48B family
CFH89_RS05965	COG0300	oxidoreductase activity
CFH89_RS05980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CFH89_RS06005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFH89_RS06010	COG2915	High frequency lysogenization protein hflD homolog
CFH89_RS06015	COG0482	sulfurtransferase activity
CFH89_RS06025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFH89_RS06035	COG1757	Na H antiporter
CFH89_RS06050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CFH89_RS06055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CFH89_RS06060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFH89_RS06065	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CFH89_RS06065	COG0131	Imidazoleglycerol-phosphate dehydratase
CFH89_RS06070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CFH89_RS06075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CFH89_RS06080	COG0107	imidazoleglycerol-phosphate synthase activity
CFH89_RS06085	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CFH89_RS06085	COG0140	phosphoribosyl-ATP diphosphatase activity
CFH89_RS06090	COG3012	SEC-C Motif Domain Protein
CFH89_RS06100	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CFH89_RS06105	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CFH89_RS06110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFH89_RS06115	COG0215	cysteine-tRNA ligase activity
CFH89_RS06120	COG1435	thymidine kinase activity
CFH89_RS06125	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CFH89_RS06150	COG2116	formate transmembrane transporter activity
CFH89_RS06160	COG0390	transport system, permease component
CFH89_RS06165	COG4459	periplasmic nitrate reductase
CFH89_RS06170	COG3005	denitrification pathway
CFH89_RS06175	COG0243	molybdopterin cofactor binding
CFH89_RS06190	COG1227	inorganic diphosphatase activity
CFH89_RS06200	COG4172	Belongs to the ABC transporter superfamily
CFH89_RS06210	COG4171	peptide transport system, permease
CFH89_RS06225	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CFH89_RS06230	COG1842	Phage shock protein A
CFH89_RS06240	COG1983	PspC domain protein
CFH89_RS06245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFH89_RS06260	COG2818	Glycosylase
CFH89_RS06265	COG5380	lipid catabolic process
CFH89_RS06270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CFH89_RS06275	COG0626	cystathionine gamma-synthase activity
CFH89_RS06285	COG0733	neurotransmitter:sodium symporter activity
CFH89_RS06295	COG0564	pseudouridine synthase activity
CFH89_RS06305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFH89_RS06310	COG1151	hydroxylamine reductase activity
CFH89_RS06315	COG3604	Transcriptional regulator
CFH89_RS06330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CFH89_RS06335	COG4136	ATPase activity
CFH89_RS06340	COG4135	transport system, permease component
CFH89_RS06345	COG4134	Bacterial extracellular solute-binding protein
CFH89_RS06350	COG0398	Pfam SNARE associated Golgi protein
CFH89_RS06360	COG0493	'glutamate synthase
CFH89_RS06385	COG3313	Fe-S protein
CFH89_RS06420	COG3778	Protein conserved in bacteria
CFH89_RS06455	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
CFH89_RS06465	COG4386	tail sheath protein
CFH89_RS06485	COG4387	Mu-like prophage protein GP36
CFH89_RS06505	COG4397	Mu-like prophage major head subunit gpT
CFH89_RS06520	COG4383	Mu-like prophage protein gp29
CFH89_RS06525	COG4373	Mu-like prophage FluMu protein gp28
CFH89_RS06540	COG0640	Transcriptional regulator
CFH89_RS06655	COG2842	Transposition protein
CFH89_RS06660	COG2801	Transposase and inactivated derivatives
CFH89_RS06665	COG3423	Transcriptional regulator
CFH89_RS06685	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CFH89_RS06705	COG1061	Type III restriction enzyme res subunit
CFH89_RS06710	COG1187	pseudouridine synthase activity
CFH89_RS06715	COG2814	Major facilitator Superfamily
CFH89_RS06745	COG3005	denitrification pathway
CFH89_RS06750	COG0702	epimerase
CFH89_RS06755	COG0534	Mate efflux family protein
CFH89_RS06760	COG4181	ATPase activity
CFH89_RS06775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CFH89_RS06795	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CFH89_RS06800	COG3273	potassium ion transport
CFH89_RS06800	COG2985	domain, Protein
CFH89_RS06805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CFH89_RS06820	COG1737	Transcriptional regulator
CFH89_RS06825	COG0076	glutamate decarboxylase activity
CFH89_RS06835	COG2431	L-lysine efflux transmembrane transporter activity
CFH89_RS06855	COG3070	regulator of competence-specific genes
CFH89_RS06870	COG4191	Histidine kinase
CFH89_RS06870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFH89_RS06880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CFH89_RS06900	COG0492	ferredoxin-NADP+ reductase activity
CFH89_RS06925	COG0471	metal ion transport
CFH89_RS06930	COG2949	membrane
CFH89_RS06935	COG0281	malic enzyme
CFH89_RS06940	COG1643	Atp-dependent helicase
CFH89_RS06960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CFH89_RS06995	COG0247	lactate metabolic process
CFH89_RS06995	COG0277	FAD linked oxidase domain protein
CFH89_RS07010	COG2986	histidine ammonia-lyase
CFH89_RS07015	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CFH89_RS07025	COG1228	amidohydrolase
CFH89_RS07030	COG2188	Transcriptional regulator
CFH89_RS07045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFH89_RS07055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CFH89_RS07065	COG0393	Putative heavy-metal-binding
CFH89_RS07095	COG3706	GGDEF domain
CFH89_RS07100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CFH89_RS07105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFH89_RS07105	COG0072	phenylalanine-tRNA ligase activity
CFH89_RS07120	COG0776	regulation of translation
CFH89_RS07130	COG0500	methyltransferase
CFH89_RS07135	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CFH89_RS07140	COG0295	cytidine deaminase activity
CFH89_RS07145	COG1346	cytolysis
CFH89_RS07150	COG1380	Effector of murein hydrolase LrgA
CFH89_RS07155	COG2925	Exonuclease
CFH89_RS07160	COG1823	symporter activity
CFH89_RS07165	COG0702	epimerase
CFH89_RS07170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CFH89_RS07175	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CFH89_RS07185	COG2062	phosphohistidine phosphatase, SixA
CFH89_RS07200	COG2988	succinylglutamate desuccinylase activity
CFH89_RS07210	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CFH89_RS07230	COG0583	DNA-binding transcription factor activity
CFH89_RS07250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CFH89_RS07255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFH89_RS07265	COG1451	nucleotide metabolic process
CFH89_RS07270	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CFH89_RS07300	COG3938	Belongs to the proline racemase family
CFH89_RS07320	COG2423	ornithine cyclodeaminase activity
CFH89_RS07325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFH89_RS07330	COG3842	ATPase activity
CFH89_RS07335	COG1176	ABC-type spermidine putrescine transport system, permease component I
CFH89_RS07340	COG1177	transmembrane transport
CFH89_RS07355	COG3291	Pkd domain containing protein
CFH89_RS07375	COG0444	Belongs to the ABC transporter superfamily
CFH89_RS07380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFH89_RS07385	COG0601	transmembrane transport
CFH89_RS07395	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFH89_RS07410	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CFH89_RS07420	COG0625	glutathione transferase activity
CFH89_RS07485	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CFH89_RS07490	COG0583	DNA-binding transcription factor activity
CFH89_RS07525	COG0471	metal ion transport
CFH89_RS07530	COG4191	Histidine kinase
CFH89_RS07530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFH89_RS07540	COG3300	MHYT domain
CFH89_RS07540	COG5001	Diguanylate cyclase
CFH89_RS07550	COG1280	lysine exporter protein (LysE YggA)
CFH89_RS07555	COG1328	CTP reductase activity
CFH89_RS07560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CFH89_RS07570	COG0861	Integral membrane protein TerC family
CFH89_RS07580	COG0739	heme binding
CFH89_RS07625	COG3501	Rhs element vgr protein
CFH89_RS07650	COG0515	serine threonine protein kinase
CFH89_RS07685	COG1522	sequence-specific DNA binding
CFH89_RS07770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CFH89_RS07785	COG0814	amino acid
CFH89_RS07810	COG1132	(ABC) transporter
CFH89_RS07815	COG1132	(ABC) transporter
CFH89_RS07845	COG0443	Heat shock 70 kDa protein
CFH89_RS07850	COG0443	Heat shock 70 kDa protein
CFH89_RS07890	COG0243	molybdopterin cofactor binding
CFH89_RS07895	COG0437	4 iron, 4 sulfur cluster binding
CFH89_RS07900	COG3302	dmso reductase anchor subunit
CFH89_RS07915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CFH89_RS07920	COG1643	Atp-dependent helicase
CFH89_RS07935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFH89_RS07945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFH89_RS07950	COG1215	transferase activity, transferring glycosyl groups
CFH89_RS07955	COG0438	transferase activity, transferring glycosyl groups
CFH89_RS08000	COG2204	response regulator
CFH89_RS08035	COG1793	dna ligase
CFH89_RS08045	COG0534	Mate efflux family protein
CFH89_RS08050	COG0307	riboflavin synthase, alpha
CFH89_RS08060	COG3001	Fructosamine kinase
CFH89_RS08065	COG2201	protein-glutamate methylesterase activity
CFH89_RS08070	COG3706	GGDEF domain
CFH89_RS08080	COG0791	NLP P60 protein
CFH89_RS08085	COG3290	protein histidine kinase activity
CFH89_RS08085	COG0840	transmembrane signaling receptor activity
CFH89_RS08120	COG3148	PFAM DTW domain containing protein
CFH89_RS08125	COG1940	carbohydrate kinase activity
CFH89_RS08140	COG0746	molybdenum cofactor guanylyltransferase activity
CFH89_RS08145	COG3842	ATPase activity
CFH89_RS08165	COG2204	response regulator
CFH89_RS08170	COG4191	Histidine kinase
CFH89_RS08180	COG0488	(ABC) transporter
CFH89_RS08185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CFH89_RS08210	COG3381	protein complex oligomerization
CFH89_RS08220	COG3383	formate dehydrogenase (NAD+) activity
CFH89_RS08220	COG0243	molybdopterin cofactor binding
CFH89_RS08225	COG0437	4 iron, 4 sulfur cluster binding
CFH89_RS08255	COG0004	ammonium transporteR
CFH89_RS08265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CFH89_RS08270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CFH89_RS08280	COG1177	transmembrane transport
CFH89_RS08290	COG3842	ATPase activity
CFH89_RS08310	COG0037	tRNA processing
CFH89_RS08320	COG0589	response to stress
CFH89_RS08325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFH89_RS08350	COG2010	Cytochrome c
CFH89_RS08380	COG2205	protein histidine kinase activity
CFH89_RS08380	COG0784	Response regulator, receiver
CFH89_RS08615	COG4128	Pfam Zonular occludens toxin
CFH89_RS08645	COG3120	sequence-specific DNA binding
CFH89_RS08655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFH89_RS08670	COG0488	(ABC) transporter
CFH89_RS08680	COG0116	Belongs to the methyltransferase superfamily
CFH89_RS08680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CFH89_RS08695	COG0167	dihydroorotate dehydrogenase activity
CFH89_RS08700	COG2902	Dehydrogenase
CFH89_RS08710	COG0308	aminopeptidase N
CFH89_RS08730	COG1956	GAF domain-containing protein
CFH89_RS08735	COG1132	(ABC) transporter
CFH89_RS08740	COG2995	paraquat-inducible protein a
CFH89_RS08775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CFH89_RS08780	COG1666	GTP binding
CFH89_RS08800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFH89_RS08805	COG4597	amino acid ABC transporter
CFH89_RS08810	COG0765	amino acid transport
CFH89_RS08815	COG1126	abc transporter atp-binding protein
CFH89_RS08820	COG0670	Belongs to the BI1 family
CFH89_RS08830	COG2920	part of a sulfur-relay system
CFH89_RS08835	COG1254	Belongs to the acylphosphatase family
CFH89_RS08840	COG0840	transmembrane signaling receptor activity
CFH89_RS08845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CFH89_RS08885	COG3706	GGDEF domain
CFH89_RS08890	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CFH89_RS08895	COG0602	queuosine metabolic process
CFH89_RS08900	COG0561	phosphatase activity
CFH89_RS08925	COG2828	Protein conserved in bacteria
CFH89_RS08935	COG0372	Belongs to the citrate synthase family
CFH89_RS08940	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CFH89_RS08970	COG0730	response to heat
CFH89_RS08990	COG0457	Tetratricopeptide repeat
CFH89_RS09060	COG4790	Type iii secretion
CFH89_RS09065	COG4794	Type iii secretion
CFH89_RS09070	COG4791	protein targeting
CFH89_RS09075	COG4792	protein secretion
CFH89_RS09085	COG1073	alpha beta
CFH89_RS09090	COG1073	alpha beta
CFH89_RS09100	COG0583	DNA-binding transcription factor activity
CFH89_RS09145	COG3177	Filamentation induced by cAMP protein fic
CFH89_RS09165	COG4669	(LipO)protein
CFH89_RS09235	COG1012	belongs to the aldehyde dehydrogenase family
CFH89_RS09240	COG3284	Transcriptional regulator
CFH89_RS09265	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CFH89_RS09270	COG0363	glucosamine-6-phosphate deaminase activity
CFH89_RS09275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFH89_RS09280	COG4565	transcriptional regulatory protein
CFH89_RS09285	COG3290	protein histidine kinase activity
CFH89_RS09300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFH89_RS09315	COG1858	cytochrome C peroxidase
CFH89_RS09320	COG0527	aspartate kinase activity
CFH89_RS09325	COG0662	Cupin 2, conserved barrel domain protein
CFH89_RS09330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CFH89_RS09335	COG0456	acetyltransferase
CFH89_RS09340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFH89_RS09360	COG4176	ABC-type proline glycine betaine transport system permease component
CFH89_RS09365	COG2113	Glycine betaine
CFH89_RS09375	COG1022	Amp-dependent synthetase and ligase
CFH89_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
CFH89_RS09395	COG0745	RESPONSE REGULATOR receiver
CFH89_RS09400	COG0642	Histidine kinase
CFH89_RS09405	COG1368	sulfuric ester hydrolase activity
CFH89_RS09430	COG1115	amino acid carrier protein
CFH89_RS09445	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CFH89_RS09485	COG1733	regulation of RNA biosynthetic process
CFH89_RS09490	COG3550	peptidyl-serine autophosphorylation
CFH89_RS09535	COG0210	DNA helicase
CFH89_RS09580	COG4804	nuclease activity
CFH89_RS09600	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CFH89_RS09615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFH89_RS09620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFH89_RS09670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CFH89_RS09680	COG1560	Kdo2-lipid A biosynthetic process
CFH89_RS09690	COG0531	amino acid
CFH89_RS09705	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CFH89_RS09710	COG3063	Type IV pilus biogenesis stability protein PilW
CFH89_RS09740	COG0110	maltose O-acetyltransferase activity
CFH89_RS09760	COG2315	Protein conserved in bacteria
CFH89_RS09765	COG1846	Transcriptional regulator
CFH89_RS09780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFH89_RS09795	COG2200	EAL domain
CFH89_RS09795	COG2771	luxR family
CFH89_RS09805	COG1227	inorganic diphosphatase activity
CFH89_RS09810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CFH89_RS09815	COG1012	belongs to the aldehyde dehydrogenase family
CFH89_RS09820	COG2957	Belongs to the agmatine deiminase family
CFH89_RS09830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFH89_RS09835	COG1012	belongs to the aldehyde dehydrogenase family
CFH89_RS09840	COG1917	Cupin 2, conserved barrel domain protein
CFH89_RS09840	COG1396	sequence-specific DNA binding
CFH89_RS09845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CFH89_RS09855	COG0174	glutamine synthetase
CFH89_RS09860	COG1757	Na H antiporter
CFH89_RS09925	COG4115	mRNA cleavage
CFH89_RS09930	COG2161	toxin-antitoxin pair type II binding
CFH89_RS10070	COG4628	conserved protein (DUF2132)
CFH89_RS10080	COG1280	lysine exporter protein (LysE YggA)
CFH89_RS10100	COG2314	TM2 domain
CFH89_RS10150	COG0346	lactoylglutathione lyase activity
CFH89_RS10220	COG0456	acetyltransferase
CFH89_RS10555	COG0251	oxidation-reduction process
CFH89_RS10755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFH89_RS10765	COG3768	UPF0283 membrane protein
CFH89_RS10770	COG3106	COG3106 Predicted ATPase
CFH89_RS10790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFH89_RS10795	COG2205	protein histidine kinase activity
CFH89_RS10795	COG0784	Response regulator, receiver
CFH89_RS10805	COG0494	nUDIX hydrolase
CFH89_RS10810	COG0814	amino acid
CFH89_RS10815	COG1760	l-serine dehydratase
CFH89_RS10820	COG2200	EAL domain
CFH89_RS10830	COG0720	synthase
CFH89_RS10840	COG0017	Asparaginyl-tRNA synthetase
CFH89_RS10850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFH89_RS10875	COG1448	Aminotransferase
CFH89_RS10895	COG0840	transmembrane signaling receptor activity
CFH89_RS10900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFH89_RS10905	COG1846	Transcriptional regulator
CFH89_RS10950	COG3108	Peptidase M15
CFH89_RS10955	COG2989	Protein conserved in bacteria
CFH89_RS10980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFH89_RS10990	COG4235	cytochrome complex assembly
CFH89_RS10990	COG3088	subunit of a heme lyase
CFH89_RS11000	COG1138	Cytochrome C-type biogenesis protein
CFH89_RS11005	COG3301	Polysulphide reductase, NrfD
CFH89_RS11010	COG0437	4 iron, 4 sulfur cluster binding
CFH89_RS11020	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CFH89_RS11040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFH89_RS11045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFH89_RS11050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFH89_RS11075	COG0019	diaminopimelate decarboxylase activity
CFH89_RS11120	COG2197	response regulator
CFH89_RS11125	COG0417	DNA replication proofreading
CFH89_RS11135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CFH89_RS11140	COG3099	Belongs to the UPF0263 family
CFH89_RS11150	COG1187	pseudouridine synthase activity
CFH89_RS11160	COG0009	L-threonylcarbamoyladenylate synthase
CFH89_RS11165	COG0613	PHP domain protein
CFH89_RS11175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFH89_RS11180	COG0512	Glutamine amidotransferase of anthranilate synthase
CFH89_RS11185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFH89_RS11190	COG0135	phosphoribosylanthranilate isomerase activity
CFH89_RS11190	COG0134	indole-3-glycerol-phosphate synthase activity
CFH89_RS11200	COG0159	tryptophan synthase activity
CFH89_RS11205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFH89_RS11210	COG0318	PFAM AMP-dependent synthetase and ligase
CFH89_RS11220	COG1301	dicarboxylic acid transport
CFH89_RS11240	COG2917	probably involved in intracellular septation
CFH89_RS11250	COG2350	Protein conserved in bacteria
CFH89_RS11260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFH89_RS11270	COG0583	DNA-binding transcription factor activity
CFH89_RS11285	COG2203	Gaf domain
CFH89_RS11285	COG3706	GGDEF domain
CFH89_RS11285	COG4251	negative regulation of phosphorylation
CFH89_RS11285	COG5001	Diguanylate cyclase
CFH89_RS11290	COG1032	radical SAM domain protein
CFH89_RS11295	COG0840	transmembrane signaling receptor activity
CFH89_RS11305	COG0745	RESPONSE REGULATOR receiver
CFH89_RS11310	COG5002	protein histidine kinase activity
CFH89_RS11310	COG3850	Histidine kinase
CFH89_RS11340	COG2842	Transposition protein
CFH89_RS11365	COG3081	Nucleoid-associated protein
CFH89_RS11390	COG3012	SEC-C Motif Domain Protein
CFH89_RS11630	COG1335	isochorismatase
CFH89_RS11635	COG1136	(ABC) transporter
CFH89_RS11635	COG0577	efflux transmembrane transporter activity
CFH89_RS11645	COG1136	(ABC) transporter
CFH89_RS11645	COG0577	efflux transmembrane transporter activity
CFH89_RS11655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFH89_RS11685	COG3118	belongs to the thioredoxin family
CFH89_RS11690	COG4232	protein-disulfide reductase activity
CFH89_RS11730	COG2863	cytochrome
CFH89_RS11735	COG3258	Cytochrome c
CFH89_RS11740	COG2995	paraquat-inducible protein a
CFH89_RS11745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CFH89_RS11745	COG3008	intermembrane lipid transfer
CFH89_RS11755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CFH89_RS11780	COG4166	transmembrane transport
CFH89_RS11785	COG0284	orotidine-5'-phosphate decarboxylase activity
CFH89_RS11790	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CFH89_RS11795	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CFH89_RS11805	COG0539	negative regulation of cytoplasmic translation
CFH89_RS11810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CFH89_RS11815	COG0616	signal peptide processing
CFH89_RS11820	COG1028	Short-chain dehydrogenase reductase Sdr
CFH89_RS11835	COG0587	DNA-directed DNA polymerase activity
CFH89_RS11840	COG0835	chemotaxis
CFH89_RS11840	COG0784	Response regulator, receiver
CFH89_RS11845	COG1940	carbohydrate kinase activity
CFH89_RS11855	COG4667	esterase of the alpha-beta hydrolase superfamily
CFH89_RS11870	COG0733	neurotransmitter:sodium symporter activity
CFH89_RS11890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFH89_RS11890	COG1263	PTS System
CFH89_RS11895	COG0084	hydrolase, TatD family'
CFH89_RS11905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CFH89_RS11910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CFH89_RS11940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFH89_RS11945	COG0416	fatty acid biosynthetic process
CFH89_RS11955	COG1399	metal-binding, possibly nucleic acid-binding protein
CFH89_RS11960	COG0424	maF-like protein
CFH89_RS11965	COG0564	pseudouridine synthase activity
CFH89_RS11980	COG1530	ribonuclease E activity
CFH89_RS11990	COG0659	secondary active sulfate transmembrane transporter activity
CFH89_RS11995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFH89_RS12000	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CFH89_RS12010	COG0572	uridine kinase
CFH89_RS12015	COG0489	protein tyrosine kinase activity
CFH89_RS12020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFH89_RS12020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFH89_RS12030	COG2186	Transcriptional regulator
CFH89_RS12035	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CFH89_RS12040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CFH89_RS12045	COG3012	SEC-C Motif Domain Protein
CFH89_RS12045	COG3318	Belongs to the UPF0149 family
CFH89_RS12050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CFH89_RS12060	COG0366	Alpha amylase catalytic
CFH89_RS12065	COG1122	ATPase activity
CFH89_RS12070	COG4120	Belongs to the binding-protein-dependent transport system permease family
CFH89_RS12080	COG3092	negative regulation of chromosome organization
CFH89_RS12085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CFH89_RS12090	COG0857	belongs to the CobB CobQ family
CFH89_RS12090	COG0280	phosphate acetyltransferase
CFH89_RS12095	COG3174	membrane
CFH89_RS12105	COG0435	Glutathione S-transferase
CFH89_RS12115	COG0444	Belongs to the ABC transporter superfamily
CFH89_RS12120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFH89_RS12125	COG0601	transmembrane transport
CFH89_RS12135	COG0314	molybdopterin synthase activity
CFH89_RS12140	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CFH89_RS12145	COG0315	cyclic pyranopterin monophosphate synthase activity
CFH89_RS12150	COG0521	Mo-molybdopterin cofactor biosynthetic process
CFH89_RS12155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CFH89_RS12160	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CFH89_RS12165	COG2198	Histidine kinase
CFH89_RS12170	COG2204	response regulator
CFH89_RS12175	COG0556	nucleotide-excision repair
CFH89_RS12190	COG4657	Part of a membrane complex involved in electron transport
CFH89_RS12195	COG2878	Part of a membrane complex involved in electron transport
CFH89_RS12200	COG4656	Part of a membrane complex involved in electron transport
CFH89_RS12205	COG4658	electron transport chain
CFH89_RS12215	COG4660	Part of a membrane complex involved in electron transport
CFH89_RS12220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CFH89_RS12225	COG0346	lactoylglutathione lyase activity
CFH89_RS12235	COG2885	chlorophyll binding
CFH89_RS12250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CFH89_RS12255	COG2056	Na+-H+ antiporter family
CFH89_RS12265	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CFH89_RS12285	COG1012	belongs to the aldehyde dehydrogenase family
CFH89_RS12285	COG1454	alcohol dehydrogenase
CFH89_RS12290	COG2095	MarC family integral membrane protein
CFH89_RS12295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFH89_RS12300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CFH89_RS12305	COG1757	Na H antiporter
CFH89_RS12320	COG3081	Nucleoid-associated protein
CFH89_RS12325	COG3082	Protein of unknown function (DUF1414)
CFH89_RS12330	COG3083	sulfuric ester hydrolase activity
CFH89_RS12340	COG0582	viral genome integration into host DNA
CFH89_RS12370	COG0582	viral genome integration into host DNA
CFH89_RS12400	COG0123	including yeast histone deacetylase and acetoin utilization protein
CFH89_RS12420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFH89_RS12425	COG0778	Nitroreductase
CFH89_RS12430	COG1902	pentaerythritol trinitrate reductase activity
CFH89_RS12430	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFH89_RS12435	COG0616	signal peptide processing
CFH89_RS12440	COG0252	asparaginase activity
CFH89_RS12445	COG3139	Protein of unknown function (DUF1315)
CFH89_RS12455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFH89_RS12460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFH89_RS12475	COG2226	methyltransferase
CFH89_RS12495	COG1785	Belongs to the alkaline phosphatase family
CFH89_RS12505	COG0346	lactoylglutathione lyase activity
CFH89_RS12510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CFH89_RS12515	COG0668	transmembrane transport
CFH89_RS12520	COG2983	Belongs to the UPF0260 family
CFH89_RS12525	COG2261	transglycosylase associated protein
CFH89_RS12540	COG3681	Belongs to the UPF0597 family
CFH89_RS12545	COG0251	oxidation-reduction process
CFH89_RS12555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFH89_RS12560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CFH89_RS12565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CFH89_RS12575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFH89_RS12580	COG2832	Protein of unknown function (DUF454)
CFH89_RS12590	COG0745	RESPONSE REGULATOR receiver
CFH89_RS12595	COG0583	DNA-binding transcription factor activity
CFH89_RS12600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CFH89_RS12605	COG1286	toxin biosynthetic process
CFH89_RS12610	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CFH89_RS12615	COG0285	dihydrofolate synthase activity
CFH89_RS12620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CFH89_RS12625	COG0101	tRNA pseudouridine synthase activity
CFH89_RS12635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CFH89_RS12640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFH89_RS12650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFH89_RS12655	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CFH89_RS12655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFH89_RS12675	COG3101	peptidyl-lysine hydroxylation
CFH89_RS12685	COG2860	membrane
CFH89_RS12690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CFH89_RS12695	COG2890	protein-(glutamine-N5) methyltransferase activity
CFH89_RS12700	COG2840	Smr protein MutS2
CFH89_RS12705	COG2062	phosphohistidine phosphatase, SixA
CFH89_RS12720	COG1024	Enoyl-CoA hydratase
CFH89_RS12720	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFH89_RS12725	COG0183	Belongs to the thiolase family
CFH89_RS12745	COG2067	long-chain fatty acid transport protein
CFH89_RS12755	COG2853	Lipoprotein
CFH89_RS12770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFH89_RS12780	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CFH89_RS12785	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFH89_RS12790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFH89_RS12795	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFH89_RS12800	COG4133	protoheme IX ABC transporter activity
CFH89_RS12810	COG0835	chemotaxis
CFH89_RS12820	COG1192	Involved in chromosome partitioning
CFH89_RS12825	COG2201	protein-glutamate methylesterase activity
CFH89_RS12830	COG2198	Histidine kinase
CFH89_RS12830	COG0643	Histidine kinase
CFH89_RS12830	COG0784	Response regulator, receiver
CFH89_RS12835	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CFH89_RS12870	COG1684	flagellar biosynthetic protein fliR
CFH89_RS12875	COG1987	bacterial-type flagellum assembly
CFH89_RS12925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CFH89_RS12935	COG1677	Flagellar hook-basal body complex protein FliE
CFH89_RS12955	COG1516	flagellar protein fliS
CFH89_RS12965	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CFH89_RS12970	COG1334	flagellar protein FlaG
CFH89_RS12975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFH89_RS12980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFH89_RS12990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFH89_RS12995	COG2837	iron assimilation
CFH89_RS13025	COG1393	Belongs to the ArsC family
CFH89_RS13030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFH89_RS13045	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CFH89_RS13050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFH89_RS13055	COG2716	regulation of RNA biosynthetic process
CFH89_RS13060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CFH89_RS13075	COG4783	chaperone-mediated protein folding
CFH89_RS13080	COG1393	Belongs to the ArsC family
CFH89_RS13100	COG2233	PERMEase
CFH89_RS13105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CFH89_RS13110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CFH89_RS13115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CFH89_RS13120	COG0121	glutamine amidotransferase
CFH89_RS13125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CFH89_RS13130	COG1960	acyl-CoA dehydrogenase activity
CFH89_RS13160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CFH89_RS13165	COG0328	RNA-DNA hybrid ribonuclease activity
CFH89_RS13170	COG2226	methyltransferase
CFH89_RS13175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFH89_RS13180	COG0741	lytic transglycosylase activity
CFH89_RS13180	COG1388	LysM domain
CFH89_RS13190	COG3021	interspecies interaction between organisms
CFH89_RS13195	COG0347	Belongs to the P(II) protein family
CFH89_RS13205	COG0037	tRNA processing
CFH89_RS13210	COG0825	malonyl-CoA metabolic process
CFH89_RS13215	COG0587	DNA-directed DNA polymerase activity
CFH89_RS13225	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CFH89_RS13230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFH89_RS13235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CFH89_RS13240	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CFH89_RS13250	COG0750	zinc metalloprotease
CFH89_RS13255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CFH89_RS13265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFH89_RS13270	COG0233	cytoplasmic translational termination
CFH89_RS13280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CFH89_RS13285	COG0052	Belongs to the universal ribosomal protein uS2 family
CFH89_RS13290	COG0024	Methionine aminopeptidase
CFH89_RS13295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CFH89_RS13305	COG0564	pseudouridine synthase activity
CFH89_RS13310	COG3098	single-species biofilm formation
CFH89_RS13335	COG1671	Belongs to the UPF0178 family
CFH89_RS13340	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CFH89_RS13350	COG0254	rRNA binding
CFH89_RS13355	COG1720	tRNA m6t6A37 methyltransferase activity
CFH89_RS13360	COG0442	prolyl-tRNA aminoacylation
CFH89_RS13380	COG0733	neurotransmitter:sodium symporter activity
CFH89_RS13395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFH89_RS13400	COG0514	ATP-dependent DNA helicase (RecQ)
CFH89_RS13405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFH89_RS13425	COG2871	sodium ion transport
CFH89_RS13430	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CFH89_RS13435	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CFH89_RS13440	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CFH89_RS13455	COG0271	Belongs to the BolA IbaG family
CFH89_RS13460	COG2813	Specifically methylates the guanine in position
CFH89_RS13465	COG3056	Lipoprotein
CFH89_RS13485	COG1595	DNA-templated transcription, initiation
CFH89_RS13515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFH89_RS13520	COG0693	protein deglycase activity
CFH89_RS13525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFH89_RS13530	COG3706	GGDEF domain
CFH89_RS13535	COG2166	iron-sulfur cluster assembly
CFH89_RS13540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CFH89_RS13545	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CFH89_RS13560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CFH89_RS13560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CFH89_RS13570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFH89_RS13575	COG1074	ATP-dependent DNA helicase activity
CFH89_RS13585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CFH89_RS13605	COG3141	response to X-ray
CFH89_RS13610	COG2171	N-acyltransferase activity
CFH89_RS13615	COG0584	glycerophosphoryl diester phosphodiesterase
CFH89_RS13620	COG2271	Major facilitator Superfamily
CFH89_RS13640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFH89_RS13645	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFH89_RS13650	COG1349	DNA-binding transcription factor activity
CFH89_RS13655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CFH89_RS13660	COG0598	Magnesium transport protein CorA
CFH89_RS13675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFH89_RS13680	COG1609	Transcriptional regulator
CFH89_RS13685	COG2211	Major facilitator Superfamily
CFH89_RS13700	COG2017	converts alpha-aldose to the beta-anomer
CFH89_RS13705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CFH89_RS13725	COG1609	Transcriptional regulator
CFH89_RS13730	COG3250	beta-galactosidase activity
CFH89_RS13735	COG2731	YhcH YjgK YiaL family protein
CFH89_RS13740	COG0531	amino acid
CFH89_RS13745	COG0583	DNA-binding transcription factor activity
CFH89_RS13805	COG4964	Belongs to the GSP D family
CFH89_RS13830	COG2169	Transcriptional regulator
CFH89_RS13835	COG1022	Amp-dependent synthetase and ligase
CFH89_RS13845	COG0583	DNA-binding transcription factor activity
CFH89_RS13850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CFH89_RS13855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CFH89_RS13865	COG0560	Phosphoserine phosphatase
CFH89_RS13875	COG0813	purine-nucleoside phosphorylase activity
CFH89_RS13880	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CFH89_RS13885	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CFH89_RS13890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CFH89_RS13895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFH89_RS13900	COG0084	hydrolase, TatD family'
CFH89_RS13910	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CFH89_RS13975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFH89_RS13980	COG3311	Transcriptional regulator
CFH89_RS14000	COG2003	Belongs to the UPF0758 family
CFH89_RS14025	COG0714	Associated with various cellular activities
CFH89_RS14040	COG0629	single-stranded DNA binding
CFH89_RS14110	COG0681	Belongs to the peptidase S26 family
CFH89_RS14125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CFH89_RS14260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFH89_RS14305	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CFH89_RS14325	COG3153	acetyltransferase
CFH89_RS14330	COG3154	lipid carrier protein
CFH89_RS14340	COG0826	peptidase U32
CFH89_RS14345	COG0826	peptidase U32
CFH89_RS14350	COG0534	Mate efflux family protein
CFH89_RS14365	COG1185	polyribonucleotide nucleotidyltransferase activity
CFH89_RS14370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CFH89_RS14375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CFH89_RS14380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CFH89_RS14385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CFH89_RS14390	COG0195	Participates in both transcription termination and antitermination
CFH89_RS14395	COG0779	Required for maturation of 30S ribosomal subunits
CFH89_RS14410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFH89_RS14420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFH89_RS14425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CFH89_RS14430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFH89_RS14435	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CFH89_RS14440	COG1534	Rna-binding protein
CFH89_RS14445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFH89_RS14450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CFH89_RS14455	COG2027	D-alanyl-D-alanine carboxypeptidase
CFH89_RS14465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFH89_RS14470	COG0739	heme binding
CFH89_RS14480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFH89_RS14485	COG0316	Belongs to the HesB IscA family
CFH89_RS14490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFH89_RS14495	COG0628	permease
CFH89_RS14500	COG2813	Specifically methylates the guanine in position
CFH89_RS14510	COG2198	Histidine kinase
CFH89_RS14510	COG2205	protein histidine kinase activity
CFH89_RS14510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFH89_RS14510	COG0784	Response regulator, receiver
CFH89_RS14515	COG0747	negative chemotaxis
CFH89_RS14525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFH89_RS14530	COG0444	Belongs to the ABC transporter superfamily
CFH89_RS14535	COG4608	Belongs to the ABC transporter superfamily
CFH89_RS14545	COG2971	BadF BadG BcrA BcrD
CFH89_RS14560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFH89_RS14575	COG1840	ABC-type Fe3 transport system, periplasmic component
CFH89_RS14580	COG0004	ammonium transporteR
CFH89_RS14590	COG3112	Uncharacterised protein family (UPF0231)
CFH89_RS14595	COG1049	propionate catabolic process, 2-methylcitrate cycle
CFH89_RS14605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFH89_RS14610	COG1643	Atp-dependent helicase
CFH89_RS14615	COG1489	DNA binding
CFH89_RS14630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFH89_RS14645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CFH89_RS14650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CFH89_RS14655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CFH89_RS14660	COG1560	Kdo2-lipid A biosynthetic process
CFH89_RS14670	COG0842	Transport permease protein
CFH89_RS14675	COG1131	(ABC) transporter
CFH89_RS14685	COG0659	secondary active sulfate transmembrane transporter activity
CFH89_RS14690	COG0288	reversible hydration of carbon dioxide
CFH89_RS14705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFH89_RS14710	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFH89_RS14715	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CFH89_RS14720	COG2186	Transcriptional regulator
CFH89_RS14730	COG0157	Belongs to the NadC ModD family
CFH89_RS14735	COG4969	Belongs to the N-Me-Phe pilin family
CFH89_RS14740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFH89_RS14745	COG1459	type II secretion system
CFH89_RS14755	COG0237	dephospho-CoA kinase activity
CFH89_RS14760	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CFH89_RS14765	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CFH89_RS14770	COG0335	large ribosomal subunit rRNA binding
CFH89_RS14775	COG0336	Belongs to the RNA methyltransferase TrmD family
CFH89_RS14780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CFH89_RS14785	COG0228	four-way junction DNA binding
CFH89_RS14790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CFH89_RS14795	COG4137	Cytochrome C assembly protein
CFH89_RS14800	COG4536	flavin adenine dinucleotide binding
CFH89_RS14805	COG1854	S-ribosylhomocysteine lyase activity
CFH89_RS14815	COG2918	glutathione biosynthetic process
CFH89_RS14820	COG0612	Peptidase, M16
CFH89_RS14825	COG1238	metal cluster binding
CFH89_RS14835	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CFH89_RS14840	COG5016	pyruvate
CFH89_RS14840	COG0511	ligase activity, forming carbon-carbon bonds
CFH89_RS14845	COG3630	sodium ion export across plasma membrane
CFH89_RS14905	COG0527	aspartate kinase activity
CFH89_RS14910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFH89_RS14915	COG2137	regulation of response to DNA damage stimulus
CFH89_RS14920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CFH89_RS14925	COG1546	Belongs to the CinA family
CFH89_RS14955	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CFH89_RS15025	COG2003	Belongs to the UPF0758 family
CFH89_RS15060	COG3335	DDE superfamily endonuclease
CFH89_RS15065	COG0582	viral genome integration into host DNA
CFH89_RS15070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CFH89_RS15085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFH89_RS15090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CFH89_RS15095	COG0585	pseudouridine synthase activity
CFH89_RS15100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CFH89_RS15105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CFH89_RS15110	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CFH89_RS15115	COG0148	phosphopyruvate hydratase activity
CFH89_RS15120	COG0504	CTP synthase activity
CFH89_RS15125	COG3956	TIGRFAM MazG family protein
CFH89_RS15130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFH89_RS15140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFH89_RS15155	COG0736	holo-[acyl-carrier-protein] synthase activity
CFH89_RS15160	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CFH89_RS15165	COG1381	Involved in DNA repair and RecF pathway recombination
CFH89_RS15170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CFH89_RS15175	COG0571	ribonuclease III activity
CFH89_RS15185	COG0481	GTPase activity
CFH89_RS15190	COG3086	response to oxidative stress
CFH89_RS15200	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CFH89_RS15205	COG1595	DNA-templated transcription, initiation
CFH89_RS15215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CFH89_RS15225	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CFH89_RS15230	COG0354	folic acid binding
CFH89_RS15245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFH89_RS15250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFH89_RS15255	COG3079	Belongs to the UPF0149 family
CFH89_RS15265	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CFH89_RS15275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CFH89_RS15280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CFH89_RS15285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFH89_RS15295	COG0583	DNA-binding transcription factor activity
CFH89_RS15305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CFH89_RS15310	COG0668	transmembrane transport
CFH89_RS15315	COG0191	fructose-bisphosphate aldolase activity
CFH89_RS15320	COG0126	phosphoglycerate kinase activity
CFH89_RS15325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFH89_RS15330	COG4771	TonB-dependent receptor
CFH89_RS15335	COG0583	DNA-binding transcription factor activity
CFH89_RS15340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CFH89_RS15350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CFH89_RS15360	COG3091	SprT-like family
CFH89_RS15365	COG2356	endonuclease I
CFH89_RS15370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CFH89_RS15375	COG0189	ligase activity
CFH89_RS15380	COG1678	Uncharacterized ACR, COG1678
CFH89_RS15385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CFH89_RS15400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CFH89_RS15405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CFH89_RS15410	COG0762	integral membrane protein
CFH89_RS15415	COG1872	DUF167
CFH89_RS15425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CFH89_RS15430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CFH89_RS15435	COG2066	Belongs to the glutaminase family
CFH89_RS15445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CFH89_RS15455	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CFH89_RS15460	COG0741	lytic transglycosylase activity
CFH89_RS15500	COG0840	transmembrane signaling receptor activity
CFH89_RS15530	COG1012	belongs to the aldehyde dehydrogenase family
CFH89_RS15580	COG3437	response regulator, receiver
CFH89_RS15590	COG3394	polysaccharide catabolic process
CFH89_RS15595	COG1486	melibiose metabolic process
CFH89_RS15600	COG1447	Phosphotransferase system cellobiose-specific component IIA
CFH89_RS15605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFH89_RS15610	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFH89_RS15615	COG0726	polysaccharide deacetylase
CFH89_RS15670	COG4974	Belongs to the 'phage' integrase family
CFH89_RS15680	COG1028	Short-chain dehydrogenase reductase Sdr
CFH89_RS15700	COG0795	lipopolysaccharide-transporting ATPase activity
CFH89_RS15705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CFH89_RS15710	COG2927	DNA polymerase III (CHI subunit)
CFH89_RS15715	COG0525	valine-tRNA ligase activity
CFH89_RS15745	COG2235	arginine
CFH89_RS15750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CFH89_RS15760	COG0540	Belongs to the ATCase OTCase family
CFH89_RS15765	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CFH89_RS15770	COG0251	oxidation-reduction process
CFH89_RS15775	COG0204	Acyl-transferase
CFH89_RS15780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFH89_RS15785	COG5007	Belongs to the BolA IbaG family
CFH89_RS15795	COG2854	intermembrane phospholipid transfer
CFH89_RS15800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CFH89_RS15810	COG1127	ABC transporter
CFH89_RS15820	COG0517	IMP dehydrogenase activity
CFH89_RS15820	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CFH89_RS15830	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CFH89_RS15835	COG1137	ATPase activity
CFH89_RS15845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CFH89_RS15850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFH89_RS15855	COG1660	Displays ATPase and GTPase activities
CFH89_RS15860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFH89_RS15865	COG2239	Acts as a magnesium transporter
CFH89_RS15870	COG0312	modulator of DNA gyrase
CFH89_RS15875	COG3028	Belongs to the UPF0307 family
CFH89_RS15880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFH89_RS15885	COG0564	pseudouridine synthase activity
CFH89_RS15900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFH89_RS15905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CFH89_RS15910	COG0312	modulator of DNA gyrase
CFH89_RS15915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFH89_RS15920	COG3164	Protein of unknown function
CFH89_RS15930	COG0424	maF-like protein
CFH89_RS15935	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CFH89_RS15940	COG1792	Involved in formation and maintenance of cell shape
CFH89_RS15945	COG1077	Cell shape determining protein MreB Mrl
CFH89_RS15990	COG1459	type II secretion system
CFH89_RS15995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFH89_RS16005	COG3267	Type II secretory pathway component ExeA
CFH89_RS16005	COG3409	Peptidoglycan-binding domain 1 protein
CFH89_RS16030	COG2199	diguanylate cyclase activity
CFH89_RS16030	COG2200	EAL domain
CFH89_RS16035	COG0629	single-stranded DNA binding
CFH89_RS16050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFH89_RS16060	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CFH89_RS16075	COG1410	methionine synthase
CFH89_RS16075	COG0646	methionine synthase
CFH89_RS16180	COG0175	sulfate reduction
CFH89_RS16185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFH89_RS16190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CFH89_RS16215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CFH89_RS16225	COG0735	belongs to the Fur family
CFH89_RS16235	COG0166	Belongs to the GPI family
CFH89_RS16240	COG0432	Pfam Uncharacterised protein family UPF0047
CFH89_RS16250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFH89_RS16265	COG0359	binds to the 23S rRNA
CFH89_RS16275	COG2965	DNA replication, synthesis of RNA primer
CFH89_RS16280	COG0360	Binds together with S18 to 16S ribosomal RNA
CFH89_RS16285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CFH89_RS16290	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CFH89_RS16300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CFH89_RS16305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CFH89_RS16345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CFH89_RS16345	COG0678	peroxiredoxin activity
CFH89_RS16360	COG0165	Argininosuccinate lyase
CFH89_RS16360	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CFH89_RS16365	COG0137	argininosuccinate synthase activity
CFH89_RS16370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CFH89_RS16375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CFH89_RS16380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFH89_RS16385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CFH89_RS16395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CFH89_RS16400	COG0527	aspartate kinase activity
CFH89_RS16400	COG0460	homoserine dehydrogenase
CFH89_RS16405	COG0626	cystathionine gamma-synthase activity
CFH89_RS16415	COG0281	malic enzyme
CFH89_RS16425	COG2906	2 iron, 2 sulfur cluster binding
CFH89_RS16430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFH89_RS16435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CFH89_RS16440	COG0049	tRNA binding
CFH89_RS16455	COG2923	Belongs to the DsrF TusC family
CFH89_RS16460	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CFH89_RS16465	COG2964	Protein conserved in bacteria
CFH89_RS16470	COG0545	Peptidyl-prolyl cis-trans isomerase
CFH89_RS16480	COG2900	Belongs to the SlyX family
CFH89_RS16485	COG1446	asparaginase
CFH89_RS16495	COG1047	Peptidyl-prolyl cis-trans
CFH89_RS16510	COG2249	NAD(P)H dehydrogenase (quinone) activity
CFH89_RS16520	COG0488	(ABC) transporter
CFH89_RS16530	COG0429	hydrolase of the alpha beta-hydrolase fold
CFH89_RS16535	COG3089	Belongs to the UPF0270 family
CFH89_RS16540	COG3954	Phosphoribulokinase
CFH89_RS16545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFH89_RS16555	COG1012	belongs to the aldehyde dehydrogenase family
CFH89_RS16565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFH89_RS16570	COG0512	Glutamine amidotransferase of anthranilate synthase
CFH89_RS16600	COG0180	Tryptophanyl-tRNA synthetase
CFH89_RS16605	COG0546	phosphoglycolate phosphatase activity
CFH89_RS16610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFH89_RS16615	COG0557	exoribonuclease II activity
CFH89_RS16620	COG1959	2 iron, 2 sulfur cluster binding
CFH89_RS16625	COG1017	nitric oxide dioxygenase activity
CFH89_RS16625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFH89_RS16630	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CFH89_RS16640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CFH89_RS16645	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CFH89_RS16650	COG0330	HflC and HflK could
CFH89_RS16660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CFH89_RS16670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CFH89_RS16680	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFH89_RS16685	COG0802	atpase or kinase
CFH89_RS16690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CFH89_RS16760	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CFH89_RS16765	COG1162	GTPase activity
CFH89_RS16770	COG0688	phosphatidylethanolamine metabolic process
CFH89_RS16775	COG0471	metal ion transport
CFH89_RS16790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CFH89_RS16795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFH89_RS16800	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CFH89_RS16805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CFH89_RS16810	COG1045	serine acetyltransferase
CFH89_RS16815	COG4942	peptidase
CFH89_RS16835	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CFH89_RS16845	COG1053	succinate dehydrogenase
CFH89_RS16850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFH89_RS16855	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CFH89_RS16860	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CFH89_RS16870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CFH89_RS16875	COG1509	lysine 2,3-aminomutase activity
CFH89_RS16890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFH89_RS16910	COG0459	protein refolding
CFH89_RS16920	COG0534	Mate efflux family protein
CFH89_RS16925	COG0205	6-phosphofructokinase activity
CFH89_RS16935	COG3678	ATP-independent chaperone mediated protein folding
CFH89_RS16945	COG0745	RESPONSE REGULATOR receiver
CFH89_RS16950	COG2205	protein histidine kinase activity
CFH89_RS16960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CFH89_RS16965	COG3030	protein affecting phage T7 exclusion by the F plasmid
CFH89_RS16970	COG1027	Aspartate ammonia-lyase
CFH89_RS16975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CFH89_RS16980	COG4232	protein-disulfide reductase activity
CFH89_RS16990	COG3263	regulation of cellular component size
CFH89_RS17000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFH89_RS17025	COG0784	Response regulator, receiver
CFH89_RS17025	COG2198	Histidine kinase
CFH89_RS17025	COG2205	protein histidine kinase activity
CFH89_RS17030	COG2814	Major facilitator Superfamily
CFH89_RS17045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFH89_RS17050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CFH89_RS17055	COG0511	ligase activity, forming carbon-carbon bonds
CFH89_RS17060	COG0439	Biotin carboxylase
CFH89_RS17070	COG2264	protein methyltransferase activity
CFH89_RS17075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CFH89_RS17080	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CFH89_RS17085	COG2814	Major facilitator Superfamily
CFH89_RS17090	COG0488	(ABC) transporter
CFH89_RS17095	COG3706	GGDEF domain
CFH89_RS17185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CFH89_RS17195	COG4206	TonB-dependent receptor
CFH89_RS17215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFH89_RS17220	COG0534	Mate efflux family protein
CFH89_RS17225	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFH89_RS17230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFH89_RS17245	COG2937	Belongs to the GPAT DAPAT family
CFH89_RS17250	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CFH89_RS17255	COG3161	chorismate lyase activity
CFH89_RS17260	COG1580	Controls the rotational direction of flagella during chemotaxis
CFH89_RS17265	COG0705	Rhomboid family
CFH89_RS17270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFH89_RS17285	COG2177	Part of the ABC transporter FtsEX involved in
CFH89_RS17290	COG2884	Cell division ATP-binding protein ftsE
CFH89_RS17295	COG0552	protein localization to endoplasmic reticulum
CFH89_RS17300	COG0742	ribosomal rna small subunit methyltransferase
CFH89_RS17310	COG2095	MarC family integral membrane protein
CFH89_RS17365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFH89_RS17370	COG0640	Transcriptional regulator
CFH89_RS17375	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CFH89_RS17380	COG1280	lysine exporter protein (LysE YggA)
CFH89_RS17385	COG2267	carboxylic ester hydrolase activity
CFH89_RS17395	COG0561	phosphatase activity
CFH89_RS17410	COG3148	PFAM DTW domain containing protein
CFH89_RS17420	COG1011	Hydrolase
CFH89_RS17425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CFH89_RS17435	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CFH89_RS17440	COG0019	diaminopimelate decarboxylase activity
CFH89_RS17450	COG1965	Belongs to the frataxin family
CFH89_RS17455	COG3072	Adenylate cyclase
CFH89_RS17460	COG0181	hydroxymethylbilane synthase activity
CFH89_RS17465	COG1587	Uroporphyrinogen-III synthase
CFH89_RS17470	COG2959	enzyme of heme biosynthesis
CFH89_RS17475	COG3071	HemY protein
CFH89_RS17485	COG3335	DDE superfamily endonuclease
CFH89_RS17530	COG0633	Ferredoxin
CFH89_RS17535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CFH89_RS17555	COG3118	belongs to the thioredoxin family
CFH89_RS17560	COG0513	Belongs to the DEAD box helicase family
CFH89_RS17565	COG0248	Ppx GppA phosphatase
CFH89_RS17570	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CFH89_RS17585	COG0514	ATP-dependent DNA helicase (RecQ)
CFH89_RS17590	COG2962	Rard protein
CFH89_RS17600	COG1280	lysine exporter protein (LysE YggA)
CFH89_RS17605	COG0405	Gamma-glutamyltransferase
CFH89_RS17615	COG0210	DNA helicase
CFH89_RS17625	COG3220	belongs to the UPF0276 family
CFH89_RS17655	COG0006	proline dipeptidase activity
CFH89_RS17655	COG0006	proline dipeptidase activity
CFH89_RS17665	COG2022	thiamine diphosphate biosynthetic process
CFH89_RS17670	COG2104	thiamine diphosphate biosynthetic process
CFH89_RS17675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CFH89_RS17685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CFH89_RS17690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFH89_RS17705	COG3335	DDE superfamily endonuclease
CFH89_RS17755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CFH89_RS17765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFH89_RS17770	COG0408	coproporphyrinogen oxidase activity
CFH89_RS17775	COG0009	L-threonylcarbamoyladenylate synthase
CFH89_RS17780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CFH89_RS17785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CFH89_RS17790	COG0551	DNA topoisomerase type I activity
CFH89_RS17795	COG2922	Belongs to the Smg family
CFH89_RS17800	COG0758	DNA mediated transformation
CFH89_RS17810	COG0242	peptide deformylase activity
CFH89_RS17815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CFH89_RS17820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CFH89_RS17820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFH89_RS17825	COG0569	domain protein
CFH89_RS17830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFH89_RS17840	COG1272	protein, Hemolysin III
CFH89_RS17845	COG4326	sporulation control protein
CFH89_RS17855	COG3084	Protein conserved in bacteria
CFH89_RS17865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CFH89_RS17870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CFH89_RS17875	COG0204	Acyl-transferase
CFH89_RS17950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CFH89_RS17955	COG0606	chelatase, subunit chli
CFH89_RS17970	COG3978	acetolactate synthase activity
CFH89_RS17975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFH89_RS17980	COG0129	dihydroxy-acid dehydratase activity
CFH89_RS17990	COG0583	DNA-binding transcription factor activity
CFH89_RS17995	COG2814	Major facilitator Superfamily
CFH89_RS18000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFH89_RS18005	COG0765	amino acid transport
CFH89_RS18010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFH89_RS18015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CFH89_RS18020	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CFH89_RS18025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CFH89_RS18030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CFH89_RS18035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFH89_RS18050	COG0356	it plays a direct role in the translocation of protons across the membrane
CFH89_RS18055	COG3312	ion transport
CFH89_RS18060	COG1475	DNA binding
CFH89_RS18065	COG1192	Involved in chromosome partitioning
CFH89_RS18070	COG0357	Ribosomal RNA small subunit methyltransferase G
CFH89_RS18075	COG0445	tRNA wobble uridine modification
CFH89_RS18080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CFH89_RS18085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CFH89_RS18090	COG0706	membrane insertase activity
CFH89_RS18100	COG0594	ribonuclease P activity
CFH89_RS18110	COG1126	abc transporter atp-binding protein
CFH89_RS18155	COG4166	transmembrane transport
CFH89_RS18175	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CFH89_RS18180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFH89_RS18180	COG1263	PTS System
CFH89_RS18185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CFH89_RS18190	COG3340	Belongs to the peptidase S51 family
CFH89_RS18210	COG1444	tRNA N-acetyltransferase activity
CFH89_RS18240	COG4608	Belongs to the ABC transporter superfamily
CFH89_RS18255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFH89_RS18255	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
CFH89_RS18280	COG0217	transcriptional regulatory protein
CFH89_RS18285	COG0772	Belongs to the SEDS family
CFH89_RS18300	COG1136	(ABC) transporter
CFH89_RS18320	COG3275	phosphorelay sensor kinase activity
CFH89_RS18325	COG3279	Response regulator of the LytR AlgR family
CFH89_RS18335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFH89_RS18370	COG0786	glutamate:sodium symporter activity
CFH89_RS18380	COG1131	(ABC) transporter
CFH89_RS18385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFH89_RS18390	COG0786	glutamate:sodium symporter activity
CFH89_RS18405	COG0363	glucosamine-6-phosphate deaminase activity
CFH89_RS18425	COG1741	Belongs to the pirin family
CFH89_RS18430	COG2259	Doxx family
CFH89_RS18445	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CFH89_RS18450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFH89_RS18460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFH89_RS18500	COG3123	guanosine phosphorylase activity
CFH89_RS18510	COG5001	Diguanylate cyclase
CFH89_RS18540	COG0583	DNA-binding transcription factor activity
CFH89_RS18545	COG0561	phosphatase activity
CFH89_RS18555	COG2199	diguanylate cyclase activity
CFH89_RS18570	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CFH89_RS18575	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CFH89_RS18580	COG0583	DNA-binding transcription factor activity
CFH89_RS18600	COG1028	Short-chain dehydrogenase reductase Sdr
CFH89_RS18610	COG1917	Cupin 2, conserved barrel domain protein
CFH89_RS18625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFH89_RS18630	COG0800	Aldolase
CFH89_RS18650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFH89_RS18655	COG0823	Involved in the tonB-independent uptake of proteins
CFH89_RS18690	COG1357	PFAM Pentapeptide repeats (8 copies)
CFH89_RS18695	COG3047	cAMP biosynthetic process
CFH89_RS18725	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CFH89_RS18725	COG3408	Glycogen debranching enzyme
CFH89_RS18730	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CFH89_RS18740	COG0583	DNA-binding transcription factor activity
CFH89_RS18750	COG0583	DNA-binding transcription factor activity
CFH89_RS18765	COG0546	phosphoglycolate phosphatase activity
CFH89_RS18790	COG3835	regulator
CFH89_RS18795	COG2610	gluconate transmembrane transporter activity
CFH89_RS18800	COG1929	Belongs to the glycerate kinase type-1 family
CFH89_RS18805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFH89_RS18825	COG0456	acetyltransferase
CFH89_RS18840	COG1028	Short-chain dehydrogenase reductase Sdr
CFH89_RS18855	COG0243	molybdopterin cofactor binding
CFH89_RS18865	COG0352	thiamine-phosphate diphosphorylase activity
CFH89_RS18870	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CFH89_RS18875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CFH89_RS18880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFH89_RS18885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFH89_RS18890	COG1116	anion transmembrane transporter activity
CFH89_RS18895	COG0351	phosphomethylpyrimidine kinase
CFH89_RS18905	COG0312	modulator of DNA gyrase
CFH89_RS18910	COG0312	modulator of DNA gyrase
CFH89_RS18915	COG1901	pseudouridine methyltransferase
CFH89_RS18975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFH89_RS18985	COG0584	glycerophosphoryl diester phosphodiesterase
CFH89_RS18990	COG0039	L-malate dehydrogenase activity
CFH89_RS18995	COG0745	RESPONSE REGULATOR receiver
CFH89_RS19020	COG0811	peptide transport
CFH89_RS19025	COG0848	biopolymer transport protein
CFH89_RS19065	COG0803	Belongs to the bacterial solute-binding protein 9 family
CFH89_RS19070	COG1121	(ABC) transporter
CFH89_RS19075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFH89_RS19090	COG1770	oligopeptidase
CFH89_RS19095	COG2814	Major facilitator Superfamily
CFH89_RS19100	COG0010	Belongs to the arginase family
CFH89_RS19105	COG1166	arginine decarboxylase activity
CFH89_RS19115	COG0189	ligase activity
CFH89_RS19115	COG4067	protein conserved in archaea
CFH89_RS19120	COG0189	ligase activity
CFH89_RS19125	COG0583	DNA-binding transcription factor activity
CFH89_RS19175	COG2199	diguanylate cyclase activity
CFH89_RS19205	COG0579	oxidoreductase
CFH89_RS19215	COG3033	Beta-eliminating lyase
CFH89_RS19235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFH89_RS19255	COG0840	transmembrane signaling receptor activity
CFH89_RS19270	COG3706	GGDEF domain
CFH89_RS19275	COG0415	Belongs to the DNA photolyase family
CFH89_RS19280	COG3046	protein related to deoxyribodipyrimidine photolyase
CFH89_RS19295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFH89_RS19295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFH89_RS19300	COG1765	OsmC-like protein
CFH89_RS19305	COG0110	maltose O-acetyltransferase activity
CFH89_RS19345	COG1011	Hydrolase
CFH89_RS19360	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CFH89_RS19370	COG2067	long-chain fatty acid transport protein
CFH89_RS19375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFH89_RS19380	COG1136	(ABC) transporter
CFH89_RS19380	COG0577	efflux transmembrane transporter activity
CFH89_RS19390	COG3240	lipase activity
CFH89_RS19420	COG1609	Transcriptional regulator
CFH89_RS19425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFH89_RS19430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CFH89_RS19435	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CFH89_RS19440	COG1840	ABC-type Fe3 transport system, periplasmic component
CFH89_RS19450	COG3842	ATPase activity
CFH89_RS19475	COG2990	Protein conserved in bacteria
CFH89_RS19485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFH89_RS19490	COG2866	Carboxypeptidase
CFH89_RS19505	COG0583	DNA-binding transcription factor activity
CFH89_RS19525	COG3104	oligopeptide transport
CFH89_RS19530	COG1760	l-serine dehydratase
CFH89_RS19550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CFH89_RS19560	COG0741	lytic transglycosylase activity
CFH89_RS19580	COG1815	bacterial-type flagellum-dependent cell motility
CFH89_RS19585	COG1558	bacterial-type flagellum-dependent cell motility
CFH89_RS19590	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CFH89_RS19595	COG1749	Flagellar hook protein flgE
CFH89_RS19600	COG4787	bacterial-type flagellum-dependent cell motility
CFH89_RS19605	COG4786	Flagellar basal body rod
CFH89_RS19610	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CFH89_RS19615	COG1706	bacterial-type flagellum-dependent cell motility
CFH89_RS19625	COG4786	Flagellar basal body rod
CFH89_RS19625	COG1256	bacterial-type flagellum assembly
CFH89_RS19630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFH89_RS19650	COG1304	FMN binding
CFH89_RS19675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFH89_RS19685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFH89_RS19690	COG0459	protein refolding
CFH89_RS19725	COG1309	transcriptional regulator
CFH89_RS19750	COG3537	Alpha-1,2-mannosidase
CFH89_RS19760	COG3537	Alpha-1,2-mannosidase
CFH89_RS19765	COG3537	Alpha-1,2-mannosidase
CFH89_RS19770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFH89_RS19780	COG0583	DNA-binding transcription factor activity
CFH89_RS19790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFH89_RS19790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFH89_RS19795	COG0346	lactoylglutathione lyase activity
CFH89_RS19800	COG1349	DNA-binding transcription factor activity
CFH89_RS19810	COG0753	catalase activity
CFH89_RS19820	COG1335	isochorismatase
CFH89_RS19830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CFH89_RS19860	COG0583	DNA-binding transcription factor activity
CFH89_RS19875	COG3713	MltA-interacting MipA family protein
CFH89_RS19885	COG3015	lipoprotein NlpE involved in copper resistance
CFH89_RS19895	COG1342	Belongs to the UPF0251 family
CFH89_RS19930	COG4948	Mandelate Racemase Muconate Lactonizing
CFH89_RS19940	COG0583	DNA-binding transcription factor activity
CFH89_RS20040	COG3842	ATPase activity
CFH89_RS20090	COG3706	GGDEF domain
CFH89_RS20110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFH89_RS20130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFH89_RS20150	COG0574	Belongs to the PEP-utilizing enzyme family
CFH89_RS20150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFH89_RS20155	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CFH89_RS20160	COG0252	asparaginase activity
CFH89_RS20165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CFH89_RS20170	COG0583	DNA-binding transcription factor activity
CFH89_RS20185	COG3122	Protein conserved in bacteria
CFH89_RS20200	COG1028	Short-chain dehydrogenase reductase Sdr
CFH89_RS20210	COG1063	alcohol dehydrogenase
CFH89_RS20215	COG1902	pentaerythritol trinitrate reductase activity
CFH89_RS20230	COG0583	DNA-binding transcription factor activity
CFH89_RS20240	COG0513	Belongs to the DEAD box helicase family
CFH89_RS20285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFH89_RS20290	COG2207	Transcriptional regulator
CFH89_RS20290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFH89_RS20320	COG2354	Protein conserved in bacteria
CFH89_RS20325	COG0418	dihydroorotase activity
CFH89_RS20335	COG0401	homolog of Blt101
CFH89_RS20345	COG3217	Mosc domain protein beta barrel domain protein
CFH89_RS20345	COG0633	Ferredoxin
CFH89_RS20345	COG0633	Ferredoxin
CFH89_RS20345	COG3217	Mosc domain protein beta barrel domain protein
CFH89_RS20350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CFH89_RS20355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CFH89_RS20405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFH89_RS20415	COG0848	biopolymer transport protein
CFH89_RS20420	COG0811	peptide transport
CFH89_RS20425	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CFH89_RS20435	COG3721	Heme iron utilization protein
CFH89_RS20440	COG0748	coenzyme F420 binding
CFH89_RS20450	COG0784	Response regulator, receiver
CFH89_RS20450	COG0835	chemotaxis
CFH89_RS20460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFH89_RS20480	COG2211	Major facilitator Superfamily
CFH89_RS20485	COG1486	melibiose metabolic process
CFH89_RS20490	COG2169	Transcriptional regulator
CFH89_RS20515	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CFH89_RS20520	COG0783	Belongs to the Dps family
CFH89_RS20530	COG0583	DNA-binding transcription factor activity
CFH89_RS20545	COG4934	collagen metabolic process
CFH89_RS20555	COG0366	Alpha amylase catalytic
CFH89_RS20575	COG2249	NAD(P)H dehydrogenase (quinone) activity
CFH89_RS20580	COG0589	response to stress
CFH89_RS20585	COG0488	(ABC) transporter
CFH89_RS20600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFH89_RS20610	COG2067	long-chain fatty acid transport protein
CFH89_RS20620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFH89_RS20675	COG3383	formate dehydrogenase (NAD+) activity
CFH89_RS20690	COG0842	Transport permease protein
CFH89_RS20695	COG1131	(ABC) transporter
CFH89_RS20705	COG0840	transmembrane signaling receptor activity
CFH89_RS20715	COG2706	6-phosphogluconolactonase activity
CFH89_RS20725	COG1881	PFAM PEBP family protein
CFH89_RS20735	COG0798	PFAM Bile acid sodium symporter
CFH89_RS20755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFH89_RS20760	COG2213	PTS system mannitol-specific
CFH89_RS20765	COG1063	alcohol dehydrogenase
CFH89_RS20775	COG1072	(Pantothenic acid kinase))
CFH89_RS20780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFH89_RS20800	COG0814	amino acid
CFH89_RS20815	COG3314	Sporulation integral membrane protein YlbJ
CFH89_RS20840	COG0739	heme binding
CFH89_RS20850	COG0583	DNA-binding transcription factor activity
CFH89_RS20880	COG0697	spore germination
CFH89_RS20910	COG2207	Transcriptional regulator
CFH89_RS20925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFH89_RS20930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CFH89_RS20940	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CFH89_RS20965	COG1612	heme a metabolic process
CFH89_RS20970	COG0109	protoheme IX farnesyltransferase activity
CFH89_RS20975	COG0545	Peptidyl-prolyl cis-trans isomerase
CFH89_RS21010	COG1278	Cold shock
CFH89_RS21015	COG3036	rescue of stalled ribosome
CFH89_RS21050	COG0577	efflux transmembrane transporter activity
CFH89_RS21050	COG1136	(ABC) transporter
CFH89_RS21060	COG0840	transmembrane signaling receptor activity
CFH89_RS21065	COG0783	Belongs to the Dps family
CFH89_RS21080	COG1454	alcohol dehydrogenase
CFH89_RS21085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CFH89_RS21125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFH89_RS21130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFH89_RS21135	COG3186	Phenylalanine-4-hydroxylase
CFH89_RS21140	COG2154	pterin-4-alpha-carbinolamine dehydratase
CFH89_RS21165	COG3530	Putative quorum-sensing-regulated virulence factor
CFH89_RS21170	COG0513	Belongs to the DEAD box helicase family
CFH89_RS21175	COG4628	conserved protein (DUF2132)
CFH89_RS21180	COG0133	tryptophan synthase activity
CFH89_RS21190	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CFH89_RS21200	COG0523	cobalamin synthesis protein
CFH89_RS21205	COG0513	Belongs to the DEAD box helicase family
CFH89_RS21225	COG2200	EAL domain
CFH89_RS21230	COG1119	ATPase activity
CFH89_RS21235	COG0840	transmembrane signaling receptor activity
CFH89_RS21260	COG0641	radical SAM
CFH89_RS21280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CFH89_RS21295	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CFH89_RS21300	COG0513	Belongs to the DEAD box helicase family
CFH89_RS21305	COG5001	Diguanylate cyclase
CFH89_RS21315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CFH89_RS21375	COG3328	transposase activity
CFH89_RS21390	COG1609	Transcriptional regulator
CFH89_RS21400	COG2182	Extracellular solute-binding protein
CFH89_RS21405	COG1175	transmembrane transport
CFH89_RS21410	COG3833	ABC-type maltose transport systems, permease component
CFH89_RS21420	COG1874	Beta-galactosidase
CFH89_RS21425	COG4580	involved in the transport of maltose and maltodextrins
CFH89_RS21430	COG0840	transmembrane signaling receptor activity
CFH89_RS21435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFH89_RS21485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFH89_RS21490	COG3550	peptidyl-serine autophosphorylation
CFH89_RS21505	COG0583	DNA-binding transcription factor activity
CFH89_RS21525	COG1902	pentaerythritol trinitrate reductase activity
CFH89_RS21530	COG1902	pentaerythritol trinitrate reductase activity
CFH89_RS21540	COG1733	regulation of RNA biosynthetic process
CFH89_RS21585	COG5413	integral membrane protein
CFH89_RS21595	COG1024	Enoyl-CoA hydratase
CFH89_RS21600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFH89_RS21605	COG1960	acyl-CoA dehydrogenase activity
CFH89_RS21615	COG0183	Belongs to the thiolase family
CFH89_RS21630	COG1024	Enoyl-CoA hydratase
CFH89_RS21635	COG1024	Enoyl-CoA hydratase
CFH89_RS21645	COG1028	Short-chain dehydrogenase reductase Sdr
CFH89_RS21650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CFH89_RS21655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFH89_RS21660	COG1845	cytochrome c oxidase, subunit III
CFH89_RS21665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CFH89_RS21670	COG0109	protoheme IX farnesyltransferase activity
CFH89_RS21685	COG1902	pentaerythritol trinitrate reductase activity
CFH89_RS21715	COG1126	abc transporter atp-binding protein
CFH89_RS21720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFH89_RS21725	COG4215	(ABC) transporter
CFH89_RS21730	COG4160	amino acid transport
CFH89_RS21745	COG0625	glutathione transferase activity
CFH89_RS21780	COG0443	Heat shock 70 kDa protein
CFH89_RS21785	COG2847	Copper chaperone PCu(A)C
CFH89_RS21810	COG4607	ABC-type enterochelin transport system periplasmic component
CFH89_RS21815	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFH89_RS21820	COG4605	iron ion homeostasis
CFH89_RS21825	COG4604	ABC transporter, ATP-binding protein
CFH89_RS21830	COG0789	Transcriptional regulator
CFH89_RS21840	COG2207	Transcriptional regulator
CFH89_RS21845	COG4771	TonB-dependent receptor
CFH89_RS21845	COG1629	transport
CFH89_RS21880	COG1289	transmembrane transporter activity
CFH89_RS21885	COG0210	DNA helicase
CFH89_RS21890	COG1803	Methylglyoxal synthase
CFH89_RS21895	COG1879	ABC-type sugar transport system periplasmic component
CFH89_RS21900	COG2198	Histidine kinase
CFH89_RS21900	COG0784	Response regulator, receiver
CFH89_RS21900	COG2205	protein histidine kinase activity
CFH89_RS21915	COG0745	RESPONSE REGULATOR receiver
CFH89_RS21920	COG3119	arylsulfatase activity
CFH89_RS21940	COG3119	arylsulfatase activity
CFH89_RS21945	COG0641	radical SAM
CFH89_RS21950	COG0714	Associated with various cellular activities
CFH89_RS21980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFH89_RS21985	COG0583	DNA-binding transcription factor activity
CFH89_RS21990	COG1597	lipid kinase activity
CFH89_RS21995	COG3111	PFAM Bacterial OB fold (BOF) protein
CFH89_RS22015	COG0641	radical SAM
CFH89_RS22045	COG0501	Belongs to the peptidase M48B family
CFH89_RS22050	COG1704	LemA family
CFH89_RS22055	COG3069	C4-dicarboxylate transmembrane transporter activity
CFH89_RS22065	COG1214	PFAM Peptidase M22, glycoprotease
CFH89_RS22065	COG0456	acetyltransferase
CFH89_RS22085	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CFH89_RS22130	COG4964	Belongs to the GSP D family
CFH89_RS22190	COG0583	DNA-binding transcription factor activity
CFH89_RS22195	COG0583	DNA-binding transcription factor activity
CFH89_RS22210	COG3300	MHYT domain
CFH89_RS22210	COG5001	Diguanylate cyclase
CFH89_RS22215	COG2197	response regulator
CFH89_RS22220	COG3706	GGDEF domain
CFH89_RS22230	COG2197	response regulator
CFH89_RS22255	COG0835	chemotaxis
CFH89_RS22255	COG0784	Response regulator, receiver
CFH89_RS22275	COG2962	Rard protein
CFH89_RS22290	COG0671	phosphoesterase, PA-phosphatase related
CFH89_RS22305	COG2076	Multidrug Resistance protein
CFH89_RS22340	COG3290	protein histidine kinase activity
CFH89_RS22345	COG4565	transcriptional regulatory protein
CFH89_RS22370	COG5642	Protein of unknown function (DUF2384)
CFH89_RS22390	COG1902	pentaerythritol trinitrate reductase activity
CFH89_RS22395	COG0346	lactoylglutathione lyase activity
CFH89_RS22445	COG0242	peptide deformylase activity
CFH89_RS22490	COG2176	DNA-directed DNA polymerase activity
CFH89_RS22495	COG0583	DNA-binding transcription factor activity
CFH89_RS22500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CFH89_RS22505	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CFH89_RS22540	COG0509	glycine decarboxylation via glycine cleavage system
CFH89_RS22545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFH89_RS22585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFH89_RS22585	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CFH89_RS22585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFH89_RS22590	COG1105	Belongs to the carbohydrate kinase PfkB family
CFH89_RS22595	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFH89_RS22595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFH89_RS22600	COG1609	Transcriptional regulator
CFH89_RS22620	COG2200	EAL domain
CFH89_RS22620	COG2203	Gaf domain
CFH89_RS22620	COG2199	diguanylate cyclase activity
CFH89_RS22625	COG0765	amino acid transport
CFH89_RS22630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFH89_RS22635	COG0765	amino acid transport
CFH89_RS22640	COG1126	abc transporter atp-binding protein
CFH89_RS22645	COG0469	pyruvate kinase activity
CFH89_RS22650	COG2271	Major facilitator Superfamily
CFH89_RS22675	COG1979	alcohol dehydrogenase
CFH89_RS22680	COG2207	Transcriptional regulator
CFH89_RS22695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CFH89_RS22700	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CFH89_RS22705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFH89_RS22725	COG0784	Response regulator, receiver
CFH89_RS22725	COG3437	response regulator, receiver
CFH89_RS22735	COG0546	phosphoglycolate phosphatase activity
CFH89_RS22755	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CFH89_RS22760	COG0513	Belongs to the DEAD box helicase family
CFH89_RS22780	COG3038	cytochrome b561
CFH89_RS22785	COG2353	YceI-like domain
CFH89_RS22790	COG2116	formate transmembrane transporter activity
CFH89_RS22795	COG0583	DNA-binding transcription factor activity
CFH89_RS22805	COG3593	DNA synthesis involved in DNA repair
CFH89_RS22810	COG0737	Belongs to the 5'-nucleotidase family
CFH89_RS22815	COG0861	Integral membrane protein TerC family
CFH89_RS22830	COG2267	carboxylic ester hydrolase activity
CFH89_RS22835	COG2067	long-chain fatty acid transport protein
CFH89_RS22850	COG2050	protein possibly involved in aromatic compounds catabolism
CFH89_RS22860	COG4533	DNA binding
CFH89_RS22885	COG0484	heat shock protein binding
CFH89_RS22895	COG3300	MHYT domain
CFH89_RS22895	COG5001	Diguanylate cyclase
CFH89_RS22900	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CFH89_RS22910	COG4181	ATPase activity
CFH89_RS22915	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CFH89_RS22925	COG1984	allophanate hydrolase subunit 2
CFH89_RS22930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CFH89_RS22935	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CFH89_RS22940	COG5002	protein histidine kinase activity
CFH89_RS22940	COG5001	Diguanylate cyclase
CFH89_RS22940	COG3447	MASE1 domain protein
CFH89_RS22945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFH89_RS22955	COG1629	transport
CFH89_RS22955	COG4771	TonB-dependent receptor
CFH89_RS22960	COG0583	DNA-binding transcription factor activity
CFH89_RS22965	COG1042	CoA-binding domain protein
CFH89_RS22965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFH89_RS22965	COG0045	succinate-CoA ligase (ADP-forming) activity
CFH89_RS22985	COG0023	Translation Initiation Factor
CFH89_RS23070	COG0583	DNA-binding transcription factor activity
CFH89_RS23080	COG0589	response to stress
CFH89_RS23085	COG3140	Belongs to the UPF0181 family
CFH89_RS23110	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CFH89_RS23115	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CFH89_RS23140	COG3706	GGDEF domain
CFH89_RS23140	COG2203	Gaf domain
CFH89_RS23140	COG4251	negative regulation of phosphorylation
CFH89_RS23140	COG5001	Diguanylate cyclase
CFH89_RS23150	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CFH89_RS23155	COG4149	molybdate abc transporter
CFH89_RS23160	COG0725	ABC transporter, periplasmic molybdate-binding protein
CFH89_RS23165	COG1492	cobalamin metabolic process
CFH89_RS23170	COG3111	PFAM Bacterial OB fold (BOF) protein
CFH89_RS23180	COG0189	ligase activity
CFH89_RS23180	COG4067	protein conserved in archaea
CFH89_RS23205	COG0602	queuosine metabolic process
CFH89_RS23210	COG1328	CTP reductase activity
CFH89_RS23225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFH89_RS23255	COG0243	molybdopterin cofactor binding
CFH89_RS23265	COG0583	DNA-binding transcription factor activity
CFH89_RS23270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CFH89_RS23280	COG2197	response regulator
CFH89_RS23285	COG3851	Histidine kinase
CFH89_RS23290	COG2271	Major facilitator Superfamily
CFH89_RS23315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFH89_RS23320	COG3118	belongs to the thioredoxin family
CFH89_RS23330	COG0745	RESPONSE REGULATOR receiver
CFH89_RS23330	COG2205	protein histidine kinase activity
CFH89_RS23330	COG3292	Two component regulator propeller
CFH89_RS23335	COG0534	Mate efflux family protein
CFH89_RS23370	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CFH89_RS23390	COG2116	formate transmembrane transporter activity
CFH89_RS23400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFH89_RS23405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFH89_RS23450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CFH89_RS23450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CFH89_RS23495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFH89_RS23515	COG0277	FAD linked oxidase domain protein
CFH89_RS23520	COG0583	DNA-binding transcription factor activity
CFH89_RS23540	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CFH89_RS23555	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CFH89_RS23570	COG1288	antiporter activity
CFH89_RS23580	COG2814	Major facilitator Superfamily
CFH89_RS23590	COG3040	lipid binding
CFH89_RS23615	COG0420	3'-5' exonuclease activity
CFH89_RS23685	COG0631	protein serine/threonine phosphatase activity
CFH89_RS23725	COG2815	serine threonine protein kinase
CFH89_RS23725	COG0515	serine threonine protein kinase
CFH89_RS23785	COG1116	anion transmembrane transporter activity
CFH89_RS23790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFH89_RS23795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFH89_RS23805	COG3707	response regulator
CFH89_RS23825	COG0243	molybdopterin cofactor binding
CFH89_RS23835	COG0814	amino acid
CFH89_RS23865	COG1785	Belongs to the alkaline phosphatase family
CFH89_RS23880	COG0745	RESPONSE REGULATOR receiver
CFH89_RS23900	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CFH89_RS23915	COG1609	Transcriptional regulator
CFH89_RS23920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFH89_RS23925	COG1879	ABC-type sugar transport system periplasmic component
CFH89_RS23930	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFH89_RS23935	COG1129	ABC transporter
CFH89_RS23940	COG1869	D-ribose catabolic process
CFH89_RS23945	COG5001	Diguanylate cyclase
CFH89_RS23950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CFH89_RS24010	COG0784	Response regulator, receiver
CFH89_RS24010	COG2205	protein histidine kinase activity
CFH89_RS24055	COG0517	IMP dehydrogenase activity
CFH89_RS24055	COG4175	Glycine betaine
CFH89_RS24060	COG4176	ABC-type proline glycine betaine transport system permease component
CFH89_RS24075	COG1012	belongs to the aldehyde dehydrogenase family
CFH89_RS24080	COG1309	transcriptional regulator
CFH89_RS24085	COG3706	GGDEF domain
CFH89_RS24095	COG1028	Short-chain dehydrogenase reductase Sdr
CFH89_RS24110	COG1024	Enoyl-CoA hydratase
CFH89_RS24115	COG1960	acyl-CoA dehydrogenase activity
CFH89_RS24125	COG0183	Belongs to the thiolase family
CFH89_RS24135	COG1960	acyl-CoA dehydrogenase activity
CFH89_RS24140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFH89_RS24150	COG4770	biotin carboxylase activity
CFH89_RS24160	COG4999	Histidine kinase
CFH89_RS24160	COG3850	Histidine kinase
CFH89_RS24160	COG3437	response regulator, receiver
CFH89_RS24160	COG2205	protein histidine kinase activity
CFH89_RS24175	COG3264	Mechanosensitive ion channel
CFH89_RS24175	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CFH89_RS24185	COG0110	maltose O-acetyltransferase activity
CFH89_RS24190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFH89_RS24195	COG1271	oxidase subunit
CFH89_RS24210	COG0384	phenazine biosynthesis protein PhzF
CFH89_RS24215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFH89_RS24220	COG0789	Transcriptional regulator
CFH89_RS24230	COG3474	cytochrome
CFH89_RS24300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFH89_RS24315	COG1196	nuclear chromosome segregation
CFH89_RS24345	COG0515	serine threonine protein kinase
CFH89_RS24390	COG2204	response regulator
CFH89_RS24400	COG0516	GMP reductase activity
CFH89_RS24405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CFH89_RS24405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CFH89_RS24420	COG4989	oxidoreductase activity
CFH89_RS24435	COG0038	chloride channel
CFH89_RS24445	COG1914	H( )-stimulated, divalent metal cation uptake system
CFH89_RS24450	COG0302	gtp cyclohydrolase
CFH89_RS24460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CFH89_RS24480	COG2897	thiosulfate sulfurtransferase activity
CFH89_RS24510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CFH89_RS24515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CFH89_RS24520	COG0840	transmembrane signaling receptor activity
CFH89_RS24530	COG2814	Major facilitator Superfamily
CFH89_RS24535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CFH89_RS24550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFH89_RS24560	COG0840	transmembrane signaling receptor activity
CFH89_RS24580	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFH89_RS24605	COG2197	response regulator
CFH89_RS24610	COG3850	Histidine kinase
CFH89_RS24625	COG0243	molybdopterin cofactor binding
CFH89_RS24635	COG3005	denitrification pathway
CFH89_RS24655	COG0183	Belongs to the thiolase family
CFH89_RS24665	COG1280	lysine exporter protein (LysE YggA)
CFH89_RS24675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFH89_RS24680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFH89_RS24710	COG1522	sequence-specific DNA binding
CFH89_RS24730	COG1566	PFAM secretion protein HlyD family protein
CFH89_RS24740	COG0784	Response regulator, receiver
CFH89_RS24740	COG2205	protein histidine kinase activity
CFH89_RS24745	COG1879	ABC-type sugar transport system periplasmic component
CFH89_RS24750	COG2827	Endonuclease containing a URI domain
CFH89_RS24770	COG2926	Belongs to the UPF0265 family
CFH89_RS24775	COG0534	Mate efflux family protein
CFH89_RS24780	COG0673	inositol 2-dehydrogenase activity
CFH89_RS24785	COG2205	protein histidine kinase activity
CFH89_RS24785	COG0784	Response regulator, receiver
CFH89_RS24785	COG5002	protein histidine kinase activity
CFH89_RS24805	COG0583	DNA-binding transcription factor activity
CFH89_RS24810	COG1522	sequence-specific DNA binding
CFH89_RS24820	COG0531	amino acid
CFH89_RS24835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CFH89_RS24840	COG2239	Acts as a magnesium transporter
CFH89_RS24850	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CFH89_RS24855	COG0402	S-adenosylhomocysteine deaminase activity
CFH89_RS24865	COG1418	mRNA catabolic process
CFH89_RS24880	COG2814	Major facilitator Superfamily
CFH89_RS24890	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFH89_RS24910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CFH89_RS24930	COG4221	oxidoreductase activity
CFH89_RS24935	COG0745	RESPONSE REGULATOR receiver
CFH89_RS24940	COG2205	protein histidine kinase activity
CFH89_RS24950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CFH89_RS24955	COG2194	sulfuric ester hydrolase activity
CFH89_RS24960	COG0673	inositol 2-dehydrogenase activity
CFH89_RS24995	COG4667	esterase of the alpha-beta hydrolase superfamily
CFH89_RS25000	COG1741	Belongs to the pirin family
CFH89_RS25005	COG1278	Cold shock
CFH89_RS25025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CFH89_RS25050	COG1686	Belongs to the peptidase S11 family
CFH89_RS25065	COG0625	glutathione transferase activity
CFH89_RS25075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CFH89_RS25100	COG1028	Short-chain dehydrogenase reductase Sdr
CFH89_RS25120	COG3746	phosphate-selective porin O and P
CFH89_RS25140	COG3833	ABC-type maltose transport systems, permease component
CFH89_RS25145	COG1175	transmembrane transport
CFH89_RS25155	COG3842	ATPase activity
CFH89_RS25215	COG3097	Belongs to the UPF0267 family
CFH89_RS25220	COG1309	transcriptional regulator
CFH89_RS25225	COG2130	NADP-dependent
CFH89_RS25235	COG0753	catalase activity
CFH89_RS25240	COG2084	Dehydrogenase
CFH89_RS25245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFH89_RS25250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFH89_RS25260	COG2207	Transcriptional regulator
CFH89_RS25265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFH89_RS25265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFH89_RS25265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFH89_RS25280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFH89_RS25285	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CFH89_RS25295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFH89_RS25300	COG0569	domain protein
CFH89_RS25310	COG2205	protein histidine kinase activity
CFH89_RS25315	COG1132	(ABC) transporter
CFH89_RS25320	COG4774	siderophore transport
CFH89_RS25325	COG1120	ATPase activity
CFH89_RS25330	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CFH89_RS25390	COG0840	transmembrane signaling receptor activity
CFH89_RS25400	COG0714	Associated with various cellular activities
CFH89_RS25420	COG2304	oxidoreductase activity
CFH89_RS25435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFH89_RS25440	COG0581	inorganic phosphate transmembrane transporter activity
CFH89_RS25445	COG0573	inorganic phosphate transmembrane transporter activity
CFH89_RS25475	COG4771	TonB-dependent receptor
CFH89_RS25480	COG1770	oligopeptidase
CFH89_RS25485	COG0513	Belongs to the DEAD box helicase family
CFH89_RS25495	COG1388	LysM domain
CFH89_RS25495	COG1376	ErfK ybiS ycfS ynhG family protein
CFH89_RS25500	COG0415	Belongs to the DNA photolyase family
CFH89_RS25505	COG0789	Transcriptional regulator
CFH89_RS25520	COG0813	purine-nucleoside phosphorylase activity
CFH89_RS25535	COG3706	GGDEF domain
CFH89_RS25545	COG1566	PFAM secretion protein HlyD family protein
CFH89_RS25550	COG4720	Psort location CytoplasmicMembrane, score
CFH89_RS25555	COG1122	ATPase activity
CFH89_RS25570	COG0348	domain, Protein
CFH89_RS25575	COG0437	4 iron, 4 sulfur cluster binding
CFH89_RS25580	COG1247	-acetyltransferase
CFH89_RS25625	COG1505	serine-type exopeptidase activity
CFH89_RS25630	COG0583	DNA-binding transcription factor activity
CFH89_RS25635	COG1620	l-lactate permease
CFH89_RS25640	COG1304	FMN binding
CFH89_RS25650	COG0668	transmembrane transport
CFH89_RS25690	COG1063	alcohol dehydrogenase
CFH89_RS25695	COG0156	8-amino-7-oxononanoate synthase activity
CFH89_RS25705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFH89_RS25735	COG0745	RESPONSE REGULATOR receiver
CFH89_RS25770	COG0346	lactoylglutathione lyase activity
CFH89_RS25790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFH89_RS25870	COG1987	bacterial-type flagellum assembly
CFH89_RS25895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFH89_RS25910	COG1516	flagellar protein fliS
CFH89_RS25925	COG1580	Controls the rotational direction of flagella during chemotaxis
CFH89_RS25930	COG1191	sigma factor activity
CFH89_RS25935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CFH89_RS25940	COG1360	Flagellar Motor Protein
CFH89_RS25970	COG1882	Formate acetyltransferase
CFH89_RS25975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CFH89_RS25980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CFH89_RS25990	COG0454	-acetyltransferase
CFH89_RS26005	COG2814	Major facilitator Superfamily
CFH89_RS26045	COG0628	permease
CFH89_RS26050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CFH89_RS26060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFH89_RS26070	COG4628	conserved protein (DUF2132)
CFH89_RS26075	COG0583	DNA-binding transcription factor activity
CFH89_RS26100	COG1686	Belongs to the peptidase S11 family
CFH89_RS26115	COG1054	Belongs to the UPF0176 family
CFH89_RS26120	COG3397	chitin binding
CFH89_RS26125	COG4667	esterase of the alpha-beta hydrolase superfamily
CFH89_RS26130	COG2095	MarC family integral membrane protein
CFH89_RS26150	COG3206	protein involved in exopolysaccharide biosynthesis
CFH89_RS26150	COG0489	protein tyrosine kinase activity
CFH89_RS26165	COG0583	DNA-binding transcription factor activity
CFH89_RS26175	COG1301	dicarboxylic acid transport
CFH89_RS26180	COG3339	Conserved Protein
CFH89_RS26185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFH89_RS26190	COG0700	Nucleoside recognition
CFH89_RS26195	COG3366	ferrous iron transmembrane transporter activity
CFH89_RS26215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFH89_RS26220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CFH89_RS26225	COG1640	4-alpha-glucanotransferase
CFH89_RS26230	COG0058	SHG alpha-glucan phosphorylase activity
CFH89_RS26245	COG2909	trisaccharide binding
CFH89_RS26260	COG1999	signal sequence binding
CFH89_RS26270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFH89_RS26270	COG1263	PTS System
CFH89_RS26275	COG1162	GTPase activity
CFH89_RS26280	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CFH89_RS26290	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CFH89_RS26300	COG0531	amino acid
CFH89_RS26305	COG1982	Orn Lys Arg decarboxylase major
CFH89_RS26325	COG2356	endonuclease I
CFH89_RS26385	COG0612	Peptidase, M16
CFH89_RS26390	COG0840	transmembrane signaling receptor activity
CFH89_RS26395	COG1120	ATPase activity
CFH89_RS26400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFH89_RS26405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFH89_RS26410	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CFH89_RS26415	COG4772	TonB-dependent receptor
CFH89_RS26440	COG4264	IucA IucC family
CFH89_RS26445	COG0019	diaminopimelate decarboxylase activity
CFH89_RS26450	COG1653	transport
CFH89_RS26480	COG0826	peptidase U32
CFH89_RS26485	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFH89_RS26490	COG1129	ABC transporter
CFH89_RS26495	COG1879	ABC-type sugar transport system periplasmic component
CFH89_RS26500	COG1069	ribulokinase activity
CFH89_RS26510	COG2160	L-arabinose isomerase activity
CFH89_RS26535	COG1764	response to oxidative stress
CFH89_RS26540	COG1846	Transcriptional regulator
CFH89_RS26550	COG3634	alkyl hydroperoxide reductase activity
CFH89_RS26585	COG1595	DNA-templated transcription, initiation
CFH89_RS26605	COG0583	DNA-binding transcription factor activity
CFH89_RS26610	COG1486	melibiose metabolic process
CFH89_RS26625	COG2258	MOSC domain
CFH89_RS26630	COG0513	Belongs to the DEAD box helicase family
CFH89_RS26640	COG2186	Transcriptional regulator
CFH89_RS26650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CFH89_RS26660	COG0246	Mannitol dehydrogenase
CFH89_RS26665	COG1904	glucuronate isomerase
CFH89_RS26670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFH89_RS26675	COG0800	Aldolase
CFH89_RS26700	COG2207	Transcriptional regulator
CFH89_RS26710	COG1132	(ABC) transporter
CFH89_RS26755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFH89_RS26785	COG0259	pyridoxamine-phosphate oxidase activity
CFH89_RS26830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFH89_RS26870	COG3504	Conjugal transfer protein
CFH89_RS26895	COG3451	type IV secretory pathway VirB4
CFH89_RS26900	COG5268	conjugation
CFH89_RS26930	COG1192	Involved in chromosome partitioning
CFH89_RS26955	COG0419	ATPase involved in DNA repair
CFH89_RS27250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFH89_RS27365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFH89_RS27390	COG2948	multi-organism process
CFH89_RS27400	COG3504	Conjugal transfer protein
CFH89_RS27430	COG3451	type IV secretory pathway VirB4
CFH89_RS27435	COG5268	conjugation
CFH89_RS27445	COG1396	sequence-specific DNA binding
CFH89_RS27475	COG1192	Involved in chromosome partitioning
CFH89_RS27555	COG2885	chlorophyll binding