locus-tag	class	description
VP0001	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VP0002	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VP0003	COG0706	membrane insertase activity
VP0004	COG0594	ribonuclease P activity
VP0006	COG1126	abc transporter atp-binding protein
VP0011	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VP0012	COG0592	DNA-directed DNA polymerase activity
VP0013	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VP0014	COG0187	DNA topoisomerase II activity
VP0018	COG0071	Belongs to the small heat shock protein (HSP20) family
VP0019	COG3977	Valine--pyruvate aminotransferase
VP0020	COG0366	Alpha amylase catalytic
VP0021	COG0751	glycine-tRNA ligase activity
VP0022	COG0752	glycyl-tRNA synthetase alpha subunit
VP0023	COG2119	membrane
VP0025	COG0425	Belongs to the sulfur carrier protein TusA family
VP0028	COG0604	alcohol dehydrogenase
VP0029	COG0183	Belongs to the thiolase family
VP0030	COG1250	3-hydroxyacyl-CoA dehydrogenase
VP0030	COG1024	Enoyl-CoA hydratase
VP0031	COG1739	Uncharacterized protein family UPF0029
VP0032	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VP0034	COG0583	DNA-binding transcription factor activity
VP0035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VP0036	COG2960	long-chain fatty acid transporting porin activity
VP0038	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VP0039	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VP0047	COG4172	Belongs to the ABC transporter superfamily
VP0048	COG0747	negative chemotaxis
VP0049	COG0601	transmembrane transport
VP0050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VP0058	COG1609	Transcriptional regulator
VP0059	COG0583	DNA-binding transcription factor activity
VP0062	COG0129	dihydroxy-acid dehydratase activity
VP0063	COG3265	gluconokinase activity
VP0064	COG2610	gluconate transmembrane transporter activity
VP0065	COG0800	Aldolase
VP0066	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VP0067	COG0583	DNA-binding transcription factor activity
VP0068	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VP0069	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VP0070	COG0339	signal peptide processing
VP0071	COG5002	protein histidine kinase activity
VP0071	COG5001	Diguanylate cyclase
VP0072	COG1522	sequence-specific DNA binding
VP0073	COG0742	ribosomal rna small subunit methyltransferase
VP0076	COG0589	response to stress
VP0077	COG1528	Iron-storage protein
VP0079	COG2081	HI0933 family
VP0085	COG1597	lipid kinase activity
VP0091	COG0628	permease
VP0094	COG1322	Protein conserved in bacteria
VP0095	COG2226	methyltransferase
VP0096	COG3165	ubiquinone biosynthetic process from chorismate
VP0097	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VP0098	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VP0099	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VP0100	COG0805	protein transport
VP0103	COG0084	hydrolase, TatD family'
VP0107	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VP0107	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VP0109	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VP0113	COG3078	GTPase activator activity
VP0116	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VP0118	COG2204	response regulator
VP0119	COG3852	Histidine kinase
VP0121	COG0174	glutamine synthetase
VP0122	COG1217	gtp-binding protein TYPA
VP0125	COG1295	ribonuclease BN
VP0126	COG1490	D-aminoacyl-tRNA deacylase activity
VP0127	COG0456	acetyltransferase
VP0129	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VP0130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VP0131	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VP0132	COG3031	protein transport across the cell outer membrane
VP0134	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VP0135	COG1459	type II secretion system
VP0136	COG2165	general secretion pathway protein
VP0137	COG2165	general secretion pathway protein
VP0138	COG2165	general secretion pathway protein
VP0139	COG4795	General secretion pathway protein
VP0140	COG3156	type II secretion system protein K
VP0141	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VP0142	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VP0144	COG1218	3'(2'),5'-bisphosphate nucleotidase
VP0145	COG0494	nUDIX hydrolase
VP0146	COG0316	Belongs to the HesB IscA family
VP0146	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VP0147	COG1040	competence protein
VP0148	COG0596	Alpha beta hydrolase
VP0150	COG2183	response to ionizing radiation
VP0152	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VP0156	COG2233	PERMEase
VP0157	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VP0158	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VP0159	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VP0160	COG1758	RNA polymerase activity
VP0161	COG0194	GDP metabolic process
VP0164	COG0848	biopolymer transport protein
VP0165	COG0811	peptide transport
VP0170	COG4174	ABC transporter (Permease)
VP0171	COG4239	(ABC) transporter, permease
VP0172	COG0747	negative chemotaxis
VP0173	COG0444	Belongs to the ABC transporter superfamily
VP0174	COG4608	Belongs to the ABC transporter superfamily
VP0176	COG1561	YicC-like family, N-terminal region
VP0177	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VP0178	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VP0179	COG1560	Kdo2-lipid A biosynthetic process
VP0180	COG1309	transcriptional regulator
VP0181	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VP0183	COG0840	transmembrane signaling receptor activity
VP0184	COG2003	Belongs to the UPF0758 family
VP0185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VP0187	COG2194	sulfuric ester hydrolase activity
VP0189	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VP0190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VP0193	COG0463	Glycosyl transferase, family 2
VP0194	COG0859	PFAM glycosyl transferase family 9
VP0195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VP0196	COG3642	lipopolysaccharide core region biosynthetic process
VP0198	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VP0199	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VP0200	COG2089	acid synthase
VP0202	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VP0205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VP0207	COG1028	Short-chain dehydrogenase reductase Sdr
VP0211	COG1519	Transferase
VP0212	COG0859	PFAM glycosyl transferase family 9
VP0213	COG1560	Kdo2-lipid A biosynthetic process
VP0214	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VP0215	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VP0231	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VP0234	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VP0238	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VP0239	COG0149	triose-phosphate isomerase activity
VP0244	COG1494	fructose-1,6-bisphosphatase
VP0246	COG3074	FtsZ-dependent cytokinesis
VP0247	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VP0248	COG1575	Belongs to the MenA family. Type 1 subfamily
VP0249	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VP0250	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VP0252	COG1609	Transcriptional regulator
VP0253	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VP0255	COG0254	rRNA binding
VP0257	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VP0258	COG0088	Forms part of the polypeptide exit tunnel
VP0260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VP0261	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VP0262	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VP0263	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VP0265	COG0255	Belongs to the universal ribosomal protein uL29 family
VP0266	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VP0267	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VP0268	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VP0269	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VP0270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VP0271	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VP0272	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VP0275	COG1841	ribosomal large subunit assembly
VP0276	COG0200	Binds to the 23S rRNA
VP0277	COG0201	protein transport
VP0278	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VP0279	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VP0280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VP0282	COG0202	RNA polymerase activity
VP0283	COG0203	ribosomal protein L17
VP0285	COG0545	Peptidyl-prolyl cis-trans isomerase
VP0287	COG2153	protein acetylation
VP0288	COG0513	Belongs to the DEAD box helicase family
VP0291	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VP0291	COG1648	precorrin-2 dehydrogenase activity
VP0292	COG0175	sulfate reduction
VP0293	COG2895	sulfate adenylyltransferase (ATP) activity
VP0295	COG3273	potassium ion transport
VP0295	COG0471	metal ion transport
VP0296	COG0529	Catalyzes the synthesis of activated sulfate
VP0301	COG4181	ATPase activity
VP0304	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VP0306	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VP0307	COG0729	surface antigen
VP0309	COG2105	PFAM AIG2 family protein
VP0311	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VP0313	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VP0314	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VP0315	COG0163	prenyltransferase activity
VP0316	COG4143	(ABC) transporter
VP0317	COG1178	ABC-type Fe3 transport system permease component
VP0318	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VP0323	COG2358	TRAP transporter, solute receptor (TAXI family
VP0325	COG0039	L-malate dehydrogenase activity
VP0327	COG0142	geranyltranstransferase activity
VP0328	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VP0330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VP0331	COG2966	Psort location CytoplasmicMembrane, score
VP0334	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VP0335	COG2967	ApaG domain
VP0336	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VP0337	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VP0338	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VP0339	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VP0340	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VP0342	COG0066	3-isopropylmalate dehydratase activity
VP0343	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VP0344	COG0473	3-isopropylmalate dehydrogenase activity
VP0346	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VP0350	COG0583	DNA-binding transcription factor activity
VP0351	COG1022	Amp-dependent synthetase and ligase
VP0352	COG0028	Belongs to the TPP enzyme family
VP0353	COG0440	acetolactate synthase activity
VP0356	COG0469	pyruvate kinase activity
VP0358	COG1349	DNA-binding transcription factor activity
VP0359	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VP0362	COG5002	protein histidine kinase activity
VP0364	COG2376	Dihydroxyacetone kinase
VP0365	COG1461	Dihydroxyacetone kinase
VP0368	COG3722	fumarate hydratase activity
VP0369	COG0246	Mannitol dehydrogenase
VP0370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VP0370	COG2213	PTS system mannitol-specific
VP0377	COG2207	Transcriptional regulator
VP0379	COG1464	Belongs to the NlpA lipoprotein family
VP0387	COG0732	type I restriction modification DNA specificity domain
VP0402	COG3550	peptidyl-serine autophosphorylation
VP0405	COG0358	DNA primase activity
VP0406	COG1610	YqeY-like protein
VP0407	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VP0408	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VP0409	COG0596	Alpha beta hydrolase
VP0410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VP0411	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VP0412	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VP0413	COG1968	undecaprenyl-diphosphatase activity
VP0414	COG0617	tRNA 3'-terminal CCA addition
VP0415	COG3267	Type II secretory pathway component ExeA
VP0415	COG3409	Peptidoglycan-binding domain 1 protein
VP0417	COG4991	sh3 domain protein
VP0418	COG0306	phosphate transporter
VP0419	COG1392	Phosphate transport regulator
VP0420	COG3025	triphosphatase activity
VP0423	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VP0424	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VP0424	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VP0425	COG1538	Outer membrane efflux protein
VP0426	COG0494	nUDIX hydrolase
VP0427	COG3151	Protein conserved in bacteria
VP0429	COG3150	esterase
VP0431	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VP0432	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VP0434	COG3105	Protein conserved in bacteria
VP0436	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VP0438	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VP0439	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VP0441	COG0723	plastoquinol--plastocyanin reductase activity
VP0442	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VP0443	COG2857	Cytochrome c1
VP0444	COG0625	glutathione transferase activity
VP0445	COG2969	positive regulation of protein catabolic process
VP0446	COG2823	Periplasmic or secreted lipoprotein
VP0447	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VP0448	COG0792	nuclease activity
VP0450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VP0452	COG0275	rRNA processing
VP0453	COG3116	cell division
VP0454	COG0768	penicillin binding
VP0455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VP0456	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VP0457	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VP0458	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VP0459	COG0772	Belongs to the SEDS family
VP0460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VP0461	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VP0462	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VP0463	COG0849	cell division
VP0464	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VP0465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VP0467	COG0653	protein targeting
VP0468	COG0494	nUDIX hydrolase
VP0469	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VP0470	COG0505	Belongs to the CarA family
VP0471	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VP0474	COG0730	response to heat
VP0475	COG0583	DNA-binding transcription factor activity
VP0476	COG2860	membrane
VP0477	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VP0479	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VP0481	COG0493	'glutamate synthase
VP0482	COG0070	glutamate synthase
VP0482	COG0069	glutamate synthase activity
VP0482	COG0067	glutamate synthase
VP0484	COG0067	glutamate synthase
VP0484	COG0070	glutamate synthase
VP0484	COG0069	glutamate synthase activity
VP0485	COG1242	4 iron, 4 sulfur cluster binding
VP0486	COG5001	Diguanylate cyclase
VP0486	COG3706	GGDEF domain
VP0486	COG2203	Gaf domain
VP0486	COG4251	negative regulation of phosphorylation
VP0487	COG5002	protein histidine kinase activity
VP0487	COG2198	Histidine kinase
VP0487	COG0784	Response regulator, receiver
VP0489	COG0745	RESPONSE REGULATOR receiver
VP0492	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VP0495	COG0083	homoserine kinase activity
VP0496	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VP0497	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VP0498	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VP0500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VP0503	COG1115	amino acid carrier protein
VP0504	COG3022	response to hydroperoxide
VP0505	COG0513	Belongs to the DEAD box helicase family
VP0506	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VP0508	COG0716	FMN binding
VP0509	COG4974	Belongs to the 'phage' integrase family
VP0510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VP0511	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VP0512	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VP0513	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VP0516	COG0667	Aldo Keto reductase
VP0518	COG3066	DNA modification
VP0520	COG0494	nUDIX hydrolase
VP0522	COG0730	response to heat
VP0523	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VP0524	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VP0526	COG1283	sodium-dependent phosphate transmembrane transporter activity
VP0527	COG0583	DNA-binding transcription factor activity
VP0529	COG0640	Transcriptional regulator
VP0531	COG0268	Binds directly to 16S ribosomal RNA
VP0532	COG0728	peptidoglycan biosynthetic process
VP0533	COG0196	riboflavin kinase activity
VP0534	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VP0535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VP0536	COG1047	Peptidyl-prolyl cis-trans
VP0537	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VP0538	COG3279	Response regulator of the LytR AlgR family
VP0539	COG3275	phosphorelay sensor kinase activity
VP0540	COG1966	Carbon starvation protein
VP0543	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VP0544	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VP0545	COG1472	Belongs to the glycosyl hydrolase 3 family
VP0546	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VP0547	COG1605	Chorismate mutase
VP0547	COG0287	Prephenate dehydrogenase
VP0548	COG0739	heme binding
VP0551	COG0488	(ABC) transporter
VP0553	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VP0554	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VP0555	COG0077	Prephenate dehydratase
VP0555	COG1605	Chorismate mutase
VP0556	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VP0557	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VP0558	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VP0559	COG0564	pseudouridine synthase activity
VP0561	COG0542	response to heat
VP0566	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VP0567	COG0826	peptidase U32
VP0568	COG2974	May be involved in recombination
VP0569	COG0745	RESPONSE REGULATOR receiver
VP0570	COG5002	protein histidine kinase activity
VP0572	COG0248	Ppx GppA phosphatase
VP0573	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VP0575	COG0581	inorganic phosphate transmembrane transporter activity
VP0576	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VP0577	COG0704	Plays a role in the regulation of phosphate uptake
VP0579	COG3142	Participates in the control of copper homeostasis
VP0580	COG0450	alkyl hydroperoxide reductase
VP0581	COG0583	DNA-binding transcription factor activity
VP0583	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VP0585	COG0517	IMP dehydrogenase activity
VP0587	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VP0588	COG0343	queuine tRNA-ribosyltransferase activity
VP0589	COG1862	Preprotein translocase
VP0590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VP0591	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VP0593	COG0483	inositol monophosphate 1-phosphatase activity
VP0595	COG1959	2 iron, 2 sulfur cluster binding
VP0596	COG1104	cysteine desulfurase activity
VP0597	COG0822	iron-sulfur transferase activity
VP0599	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VP0600	COG0443	Heat shock 70 kDa protein
VP0601	COG0633	Ferredoxin
VP0602	COG2975	iron-sulfur cluster assembly
VP0603	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VP0604	COG0105	UTP biosynthetic process
VP0605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VP0608	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VP0609	COG0124	histidyl-tRNA synthetase
VP0610	COG2976	Protein conserved in bacteria
VP0611	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VP0612	COG1160	GTP binding
VP0615	COG1570	exodeoxyribonuclease VII activity
VP0616	COG0517	IMP dehydrogenase activity
VP0616	COG0516	GMP reductase activity
VP0617	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VP0617	COG0519	Catalyzes the synthesis of GMP from XMP
VP0618	COG1757	Na H antiporter
VP0620	COG1584	GPR1 FUN34 yaaH family protein
VP0622	COG1115	amino acid carrier protein
VP0629	COG2873	o-acetylhomoserine
VP0630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VP0634	COG3153	acetyltransferase
VP0634	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VP0635	COG0583	DNA-binding transcription factor activity
VP0642	COG0328	RNA-DNA hybrid ribonuclease activity
VP0644	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VP0645	COG2867	negative regulation of translational initiation
VP0646	COG2914	Belongs to the UPF0125 (RnfH) family
VP0647	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VP0648	COG0497	DNA recombination
VP0650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VP0651	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VP0653	COG0443	Heat shock 70 kDa protein
VP0654	COG0484	heat shock protein binding
VP0657	COG4969	Belongs to the N-Me-Phe pilin family
VP0662	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VP0665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VP0666	COG0047	phosphoribosylformylglycinamidine synthase activity
VP0666	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VP0671	COG2195	Cleaves the N-terminal amino acid of tripeptides
VP0672	COG2252	PERMEase
VP0673	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VP0674	COG1073	alpha beta
VP0676	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VP0677	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VP0678	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VP0679	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VP0679	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VP0683	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VP0684	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VP0685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VP0686	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VP0687	COG0142	geranyltranstransferase activity
VP0688	COG1722	exodeoxyribonuclease VII activity
VP0689	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VP0690	COG2885	chlorophyll binding
VP0691	COG0301	tRNA thio-modification
VP0691	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VP0692	COG0583	DNA-binding transcription factor activity
VP0694	COG2363	Small membrane protein
VP0695	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VP0697	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VP0698	COG1611	Belongs to the LOG family
VP0701	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VP0701	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VP0703	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VP0704	COG1464	Belongs to the NlpA lipoprotein family
VP0705	COG2011	ABC-type metal ion transport system permease component
VP0706	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VP0708	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VP0710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VP0710	COG1263	PTS System
VP0711	COG0366	Alpha amylase catalytic
VP0714	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VP0715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VP0716	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VP0717	COG0321	lipoyl(octanoyl) transferase activity
VP0718	COG2921	Belongs to the UPF0250 family
VP0719	COG1686	Belongs to the peptidase S11 family
VP0720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VP0721	COG0772	Belongs to the SEDS family
VP0722	COG0768	penicillin binding
VP0723	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VP0724	COG0799	negative regulation of ribosome biogenesis
VP0725	COG1466	dna polymerase III delta subunit
VP0726	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VP0727	COG0495	leucyl-tRNA aminoacylation
VP0728	COG2888	peptidyl-tyrosine sulfation
VP0729	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VP0730	COG4535	Mg2 and Co2 transporter CorC
VP0731	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VP0732	COG1702	phosphate starvation-inducible protein PhoH
VP0733	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VP0735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VP0737	COG0012	GTP binding
VP0738	COG0193	aminoacyl-tRNA hydrolase activity
VP0739	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VP0740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VP0741	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VP0742	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VP0743	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VP0744	COG2890	protein-(glutamine-N5) methyltransferase activity
VP0745	COG3094	Invasion gene expression up-regulator, SirB
VP0746	COG2912	Transglutaminase-like superfamily
VP0747	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VP0748	COG0737	Belongs to the 5'-nucleotidase family
VP0750	COG1187	pseudouridine synthase activity
VP0751	COG2840	Smr protein MutS2
VP0758	COG2217	Heavy metal translocating P-type atpase
VP0758	COG2608	mercury ion transmembrane transporter activity
VP0761	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VP0762	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VP0773	COG0835	chemotaxis
VP0773	COG0784	Response regulator, receiver
VP0774	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VP0775	COG1815	bacterial-type flagellum-dependent cell motility
VP0776	COG1558	bacterial-type flagellum-dependent cell motility
VP0778	COG1749	Flagellar hook protein flgE
VP0780	COG4787	bacterial-type flagellum-dependent cell motility
VP0782	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VP0783	COG1706	bacterial-type flagellum-dependent cell motility
VP0784	COG1705	Flagellar rod assembly protein muramidase FlgJ
VP0784	COG3951	Flagellar rod assembly protein muramidase FlgJ
VP0786	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VP0788	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VP0790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VP0791	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VP0793	COG2190	(PTS) system
VP0794	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VP0795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VP0797	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VP0798	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VP0799	COG3115	cell septum assembly
VP0800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VP0805	COG0330	HflC and HflK could
VP0806	COG3118	belongs to the thioredoxin family
VP0808	COG0300	oxidoreductase activity
VP0809	COG1090	epimerase
VP0816	COG0622	Phosphoesterase
VP0820	COG3710	Transcriptional regulator
VP0821	COG0326	Molecular chaperone. Has ATPase activity
VP0822	COG0563	adenylate kinase activity
VP0823	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VP0824	COG3104	oligopeptide transport
VP0825	COG0250	Participates in transcription elongation, termination and antitermination
VP0826	COG0367	asparagine synthase
VP0827	COG4651	solute:proton antiporter activity
VP0827	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VP0828	COG1846	Transcriptional regulator
VP0828	COG1940	carbohydrate kinase activity
VP0829	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VP0831	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VP0831	COG1263	PTS System
VP0832	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VP0833	COG0735	belongs to the Fur family
VP0837	COG0596	Alpha beta hydrolase
VP0838	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VP0839	COG0033	Phosphoglucomutase
VP0841	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VP0844	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VP0845	COG1053	succinate dehydrogenase
VP0846	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VP0847	COG0567	Dehydrogenase, E1 component
VP0848	COG0508	dehydrogenase complex catalyzes the overall conversion of
VP0849	COG0045	succinate-CoA ligase (ADP-forming) activity
VP0851	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VP0852	COG1121	(ABC) transporter
VP0853	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VP0854	COG4977	sequence-specific DNA binding
VP0857	COG1918	ferrous iron import across plasma membrane
VP0861	COG0018	arginyl-trna synthetase
VP0863	COG3102	Protein conserved in bacteria
VP0864	COG0788	formyltetrahydrofolate deformylase activity
VP0865	COG1199	ATP-dependent helicase activity
VP0866	COG1214	PFAM Peptidase M22, glycoprotease
VP0869	COG2267	carboxylic ester hydrolase activity
VP0870	COG0318	PFAM AMP-dependent synthetase and ligase
VP0871	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VP0872	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VP0873	COG2894	cell division
VP0874	COG0850	regulation of cytokinetic process
VP0875	COG3100	YcgL domain-containing protein
VP0876	COG2951	lytic endotransglycosylase activity
VP0877	COG0583	DNA-binding transcription factor activity
VP0878	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VP0879	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VP0881	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VP0882	COG1028	Short-chain dehydrogenase reductase Sdr
VP0884	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VP0889	COG2986	histidine ammonia-lyase
VP0890	COG1216	Glycosyl transferase, family 2
VP0891	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VP0894	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VP0895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VP0902	COG1253	flavin adenine dinucleotide binding
VP0903	COG0513	Belongs to the DEAD box helicase family
VP0904	COG0569	domain protein
VP0905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VP0909	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VP0910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VP0911	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VP0912	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VP0914	COG2204	response regulator
VP0916	COG0544	peptidyl-prolyl cis-trans isomerase activity
VP0917	COG0740	serine-type endopeptidase activity
VP0918	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VP0919	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VP0920	COG0776	regulation of translation
VP0921	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VP0922	COG1555	photosystem II stabilization
VP0925	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VP0926	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VP0927	COG0436	Aminotransferase
VP0928	COG1169	isochorismate synthase
VP0929	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VP0930	COG0596	Alpha beta hydrolase
VP0931	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VP0936	COG2855	membrane
VP0937	COG0477	Major facilitator Superfamily
VP0941	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VP0947	COG1522	sequence-specific DNA binding
VP0949	COG1946	Acyl-CoA thioesterase
VP0950	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VP0953	COG2199	diguanylate cyclase activity
VP0954	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VP0955	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VP0956	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VP0958	COG0517	IMP dehydrogenase activity
VP0958	COG0516	GMP reductase activity
VP0964	COG0537	adenosine 5'-monophosphoramidase activity
VP0969	COG3150	esterase
VP0971	COG1252	NADH dehydrogenase
VP0975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VP0977	COG4591	ABC-type transport system involved in lipoprotein release permease component
VP0978	COG1136	(ABC) transporter
VP0979	COG4591	ABC-type transport system involved in lipoprotein release permease component
VP0981	COG0658	competence protein
VP0981	COG2333	competence protein COMEC
VP0982	COG1132	(ABC) transporter
VP0983	COG1663	tetraacyldisaccharide 4'-kinase activity
VP0984	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VP0985	COG2719	SpoVR family
VP0986	COG2718	Belongs to the UPF0229 family
VP0988	COG2766	serine protein kinase
VP0990	COG3013	Belongs to the UPF0304 family
VP0992	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VP0994	COG1882	Formate acetyltransferase
VP1003	COG0708	Exodeoxyribonuclease III
VP1005	COG3923	Primosomal replication protein n
VP1006	COG0730	response to heat
VP1007	COG1199	ATP-dependent helicase activity
VP1009	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VP1010	COG1187	pseudouridine synthase activity
VP1012	COG1278	Cold shock
VP1013	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VP1014	COG0542	response to heat
VP1016	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VP1017	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VP1018	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VP1020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VP1022	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VP1023	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VP1024	COG0297	glycogen (starch) synthase activity
VP1028	COG3070	regulator of competence-specific genes
VP1030	COG1609	Transcriptional regulator
VP1031	COG3381	protein complex oligomerization
VP1032	COG0745	RESPONSE REGULATOR receiver
VP1033	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VP1034	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VP1035	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VP1036	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VP1037	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VP1043	COG0189	ligase activity
VP1043	COG4067	protein conserved in archaea
VP1044	COG0500	methyltransferase
VP1045	COG4106	trans-aconitate 2-methyltransferase activity
VP1046	COG1801	Protein of unknown function DUF72
VP1047	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VP1048	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VP1051	COG0632	four-way junction helicase activity
VP1052	COG2255	four-way junction helicase activity
VP1053	COG1271	oxidase subunit
VP1054	COG1294	oxidase, subunit
VP1056	COG0824	Thioesterase
VP1057	COG0811	peptide transport
VP1060	COG0823	Involved in the tonB-independent uptake of proteins
VP1061	COG2885	chlorophyll binding
VP1062	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VP1063	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VP1065	COG3766	membrane
VP1067	COG0754	glutathionylspermidine amidase activity
VP1069	COG5002	protein histidine kinase activity
VP1069	COG0784	Response regulator, receiver
VP1077	COG0582	viral genome integration into host DNA
VP1085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VP1088	COG0840	transmembrane signaling receptor activity
VP1091	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VP1092	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VP1098	COG3568	Endonuclease Exonuclease Phosphatase
VP1101	COG0583	DNA-binding transcription factor activity
VP1103	COG0686	Belongs to the AlaDH PNT family
VP1105	COG1674	ftsk spoiiie
VP1106	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VP1107	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VP1108	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VP1111	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VP1113	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VP1114	COG0156	8-amino-7-oxononanoate synthase activity
VP1116	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VP1118	COG0501	Belongs to the peptidase M48B family
VP1120	COG0300	oxidoreductase activity
VP1123	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VP1128	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VP1129	COG2915	High frequency lysogenization protein hflD homolog
VP1130	COG0482	sulfurtransferase activity
VP1132	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VP1134	COG1757	Na H antiporter
VP1137	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VP1138	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VP1139	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VP1140	COG0131	Imidazoleglycerol-phosphate dehydratase
VP1140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VP1141	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VP1142	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VP1143	COG0107	imidazoleglycerol-phosphate synthase activity
VP1144	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VP1144	COG0140	phosphoribosyl-ATP diphosphatase activity
VP1145	COG3012	SEC-C Motif Domain Protein
VP1147	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VP1148	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VP1149	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VP1150	COG0215	cysteine-tRNA ligase activity
VP1151	COG1435	thymidine kinase activity
VP1152	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VP1157	COG2116	formate transmembrane transporter activity
VP1159	COG0390	transport system, permease component
VP1160	COG4459	periplasmic nitrate reductase
VP1161	COG3005	denitrification pathway
VP1162	COG0243	molybdopterin cofactor binding
VP1165	COG1227	inorganic diphosphatase activity
VP1167	COG4172	Belongs to the ABC transporter superfamily
VP1169	COG4171	peptide transport system, permease
VP1172	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VP1173	COG1842	Phage shock protein A
VP1175	COG1983	PspC domain protein
VP1176	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VP1179	COG2818	Glycosylase
VP1180	COG5380	lipid catabolic process
VP1181	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VP1182	COG0626	cystathionine gamma-synthase activity
VP1184	COG0733	neurotransmitter:sodium symporter activity
VP1186	COG0564	pseudouridine synthase activity
VP1188	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VP1189	COG1151	hydroxylamine reductase activity
VP1190	COG3604	Transcriptional regulator
VP1193	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VP1194	COG4136	ATPase activity
VP1195	COG4135	transport system, permease component
VP1196	COG4134	Bacterial extracellular solute-binding protein
VP1197	COG0398	Pfam SNARE associated Golgi protein
VP1199	COG0493	'glutamate synthase
VP1204	COG3313	Fe-S protein
VP1210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VP1214	COG1061	Type III restriction enzyme res subunit
VP1215	COG1187	pseudouridine synthase activity
VP1216	COG2814	Major facilitator Superfamily
VP1222	COG3005	denitrification pathway
VP1223	COG0702	epimerase
VP1224	COG0534	Mate efflux family protein
VP1225	COG4181	ATPase activity
VP1228	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VP1231	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VP1232	COG3273	potassium ion transport
VP1232	COG2985	domain, Protein
VP1233	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VP1236	COG1737	Transcriptional regulator
VP1237	COG0076	glutamate decarboxylase activity
VP1239	COG2431	L-lysine efflux transmembrane transporter activity
VP1241	COG3070	regulator of competence-specific genes
VP1245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VP1245	COG4191	Histidine kinase
VP1247	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VP1248	COG3048	D-serine ammonia-lyase activity
VP1249	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VP1250	COG4988	ABC transporter
VP1251	COG0492	ferredoxin-NADP+ reductase activity
VP1256	COG0471	metal ion transport
VP1257	COG2949	membrane
VP1258	COG0281	malic enzyme
VP1259	COG1643	Atp-dependent helicase
VP1260	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
VP1263	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VP1270	COG0277	FAD linked oxidase domain protein
VP1270	COG0247	lactate metabolic process
VP1273	COG2986	histidine ammonia-lyase
VP1274	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VP1275	COG0010	Belongs to the arginase family
VP1276	COG1228	amidohydrolase
VP1277	COG2188	Transcriptional regulator
VP1280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VP1281	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VP1283	COG0393	Putative heavy-metal-binding
VP1289	COG3706	GGDEF domain
VP1290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VP1291	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VP1291	COG0072	phenylalanine-tRNA ligase activity
VP1294	COG0776	regulation of translation
VP1296	COG0500	methyltransferase
VP1297	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VP1298	COG0295	cytidine deaminase activity
VP1299	COG1346	cytolysis
VP1300	COG1380	Effector of murein hydrolase LrgA
VP1301	COG2925	Exonuclease
VP1302	COG1823	symporter activity
VP1303	COG0702	epimerase
VP1304	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VP1305	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VP1310	COG2988	succinylglutamate desuccinylase activity
VP1311	COG4139	cobalamin transport
VP1312	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VP1316	COG0583	DNA-binding transcription factor activity
VP1320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VP1321	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VP1322	COG3475	LICD family
VP1323	COG1451	nucleotide metabolic process
VP1324	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VP1330	COG3938	Belongs to the proline racemase family
VP1333	COG2423	ornithine cyclodeaminase activity
VP1335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VP1336	COG3842	ATPase activity
VP1337	COG1176	ABC-type spermidine putrescine transport system, permease component I
VP1338	COG1177	transmembrane transport
VP1340	COG3291	Pkd domain containing protein
VP1344	COG0444	Belongs to the ABC transporter superfamily
VP1345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VP1346	COG0601	transmembrane transport
VP1348	COG2195	Cleaves the N-terminal amino acid of tripeptides
VP1350	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VP1352	COG0625	glutathione transferase activity
VP1361	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VP1363	COG1127	ABC transporter
VP1365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VP1366	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VP1367	COG0583	DNA-binding transcription factor activity
VP1374	COG0471	metal ion transport
VP1375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VP1375	COG4191	Histidine kinase
VP1377	COG3300	MHYT domain
VP1377	COG5001	Diguanylate cyclase
VP1379	COG1280	lysine exporter protein (LysE YggA)
VP1380	COG1328	CTP reductase activity
VP1381	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VP1383	COG0861	Integral membrane protein TerC family
VP1385	COG0739	heme binding
VP1391	COG2204	response regulator
VP1394	COG3501	Rhs element vgr protein
VP1400	COG0515	serine threonine protein kinase
VP1407	COG1522	sequence-specific DNA binding
VP1423	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VP1426	COG0814	amino acid
VP1431	COG1132	(ABC) transporter
VP1432	COG1132	(ABC) transporter
VP1438	COG0443	Heat shock 70 kDa protein
VP1439	COG0443	Heat shock 70 kDa protein
VP1441	COG3706	GGDEF domain
VP1447	COG0243	molybdopterin cofactor binding
VP1448	COG0437	4 iron, 4 sulfur cluster binding
VP1449	COG3302	dmso reductase anchor subunit
VP1452	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VP1453	COG1643	Atp-dependent helicase
VP1456	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VP1458	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VP1459	COG1215	transferase activity, transferring glycosyl groups
VP1461	COG0438	transferase activity, transferring glycosyl groups
VP1467	COG0438	transferase activity, transferring glycosyl groups
VP1469	COG2204	response regulator
VP1477	COG1793	dna ligase
VP1479	COG0534	Mate efflux family protein
VP1480	COG0307	riboflavin synthase, alpha
VP1481	COG3001	Fructosamine kinase
VP1482	COG2201	protein-glutamate methylesterase activity
VP1483	COG3706	GGDEF domain
VP1485	COG0791	NLP P60 protein
VP1486	COG0840	transmembrane signaling receptor activity
VP1493	COG3148	PFAM DTW domain containing protein
VP1494	COG1940	carbohydrate kinase activity
VP1496	COG0303	'Molybdopterin
VP1497	COG0746	molybdenum cofactor guanylyltransferase activity
VP1498	COG3842	ATPase activity
VP1502	COG2204	response regulator
VP1503	COG4191	Histidine kinase
VP1504	COG0488	(ABC) transporter
VP1506	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VP1513	COG0243	molybdopterin cofactor binding
VP1513	COG3383	formate dehydrogenase (NAD+) activity
VP1514	COG0437	4 iron, 4 sulfur cluster binding
VP1523	COG0004	ammonium transporteR
VP1524	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VP1525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VP1527	COG1177	transmembrane transport
VP1529	COG3842	ATPase activity
VP1533	COG0037	tRNA processing
VP1535	COG0589	response to stress
VP1536	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VP1539	COG2217	Heavy metal translocating P-type atpase
VP1541	COG2010	Cytochrome c
VP1544	COG3278	Belongs to the heme-copper respiratory oxidase family
VP1547	COG0784	Response regulator, receiver
VP1547	COG2205	protein histidine kinase activity
VP1589	COG3120	sequence-specific DNA binding
VP1590	COG1067	ATP-dependent peptidase activity
VP1591	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VP1595	COG0488	(ABC) transporter
VP1597	COG0116	Belongs to the methyltransferase superfamily
VP1597	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VP1601	COG0167	dihydroorotate dehydrogenase activity
VP1602	COG2902	Dehydrogenase
VP1604	COG0308	aminopeptidase N
VP1607	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VP1608	COG1956	GAF domain-containing protein
VP1609	COG1132	(ABC) transporter
VP1610	COG2995	paraquat-inducible protein a
VP1611	COG3008	intermembrane lipid transfer
VP1612	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VP1612	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VP1616	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VP1617	COG1666	GTP binding
VP1620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VP1621	COG4597	amino acid ABC transporter
VP1622	COG0765	amino acid transport
VP1623	COG1126	abc transporter atp-binding protein
VP1624	COG0670	Belongs to the BI1 family
VP1626	COG2920	part of a sulfur-relay system
VP1627	COG1254	Belongs to the acylphosphatase family
VP1628	COG0840	transmembrane signaling receptor activity
VP1629	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VP1637	COG3706	GGDEF domain
VP1638	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VP1639	COG0602	queuosine metabolic process
VP1640	COG0561	phosphatase activity
VP1645	COG2828	Protein conserved in bacteria
VP1647	COG0372	Belongs to the citrate synthase family
VP1648	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VP1654	COG0730	response to heat
VP1658	COG0457	Tetratricopeptide repeat
VP1672	COG4790	Type iii secretion
VP1673	COG4794	Type iii secretion
VP1674	COG4791	protein targeting
VP1675	COG4792	protein secretion
VP1677	COG1073	alpha beta
VP1678	COG1073	alpha beta
VP1686	COG3177	Filamentation induced by cAMP protein fic
VP1690	COG4669	(LipO)protein
VP1703	COG1012	belongs to the aldehyde dehydrogenase family
VP1704	COG3284	Transcriptional regulator
VP1708	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VP1709	COG0363	glucosamine-6-phosphate deaminase activity
VP1710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VP1711	COG4565	transcriptional regulatory protein
VP1712	COG3290	protein histidine kinase activity
VP1714	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VP1718	COG1858	cytochrome C peroxidase
VP1719	COG0527	aspartate kinase activity
VP1720	COG0662	Cupin 2, conserved barrel domain protein
VP1721	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VP1722	COG0456	acetyltransferase
VP1723	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VP1727	COG4176	ABC-type proline glycine betaine transport system permease component
VP1728	COG2113	Glycine betaine
VP1732	COG1028	Short-chain dehydrogenase reductase Sdr
VP1734	COG0745	RESPONSE REGULATOR receiver
VP1735	COG0642	Histidine kinase
VP1736	COG1368	sulfuric ester hydrolase activity
VP1741	COG1115	amino acid carrier protein
VP1743	COG1280	lysine exporter protein (LysE YggA)
VP1744	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VP1745	COG1560	Kdo2-lipid A biosynthetic process
VP1747	COG0531	amino acid
VP1751	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VP1752	COG3063	Type IV pilus biogenesis stability protein PilW
VP1758	COG0110	maltose O-acetyltransferase activity
VP1762	COG2315	Protein conserved in bacteria
VP1763	COG1846	Transcriptional regulator
VP1766	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VP1768	COG2771	luxR family
VP1768	COG2200	EAL domain
VP1770	COG1227	inorganic diphosphatase activity
VP1771	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VP1772	COG1012	belongs to the aldehyde dehydrogenase family
VP1773	COG2957	Belongs to the agmatine deiminase family
VP1775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VP1776	COG1012	belongs to the aldehyde dehydrogenase family
VP1777	COG1012	belongs to the aldehyde dehydrogenase family
VP1778	COG1396	sequence-specific DNA binding
VP1778	COG1917	Cupin 2, conserved barrel domain protein
VP1779	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VP1781	COG0174	glutamine synthetase
VP1782	COG1757	Na H antiporter
VP1787	COG2801	Transposase and inactivated derivatives
VP1797	COG0251	oxidation-reduction process
VP1812	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VP1820	COG4115	mRNA cleavage
VP1821	COG2161	toxin-antitoxin pair type II binding
VP1826	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VP1864	COG0346	lactoylglutathione lyase activity
VP1868	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VP1870	COG3768	UPF0283 membrane protein
VP1871	COG3106	COG3106 Predicted ATPase
VP1875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VP1876	COG2205	protein histidine kinase activity
VP1876	COG0784	Response regulator, receiver
VP1878	COG0494	nUDIX hydrolase
VP1879	COG0814	amino acid
VP1880	COG1760	l-serine dehydratase
VP1881	COG2200	EAL domain
VP1883	COG0720	synthase
VP1889	COG1278	Cold shock
VP1890	COG0557	exoribonuclease II activity
VP1892	COG0840	transmembrane signaling receptor activity
VP1893	COG0017	Asparaginyl-tRNA synthetase
VP1896	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VP1900	COG1448	Aminotransferase
VP1905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VP1906	COG1846	Transcriptional regulator
VP1911	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VP1914	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VP1915	COG3108	Peptidase M15
VP1916	COG2989	Protein conserved in bacteria
VP1921	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VP1923	COG4235	cytochrome complex assembly
VP1923	COG3088	subunit of a heme lyase
VP1925	COG1138	Cytochrome C-type biogenesis protein
VP1926	COG3301	Polysulphide reductase, NrfD
VP1927	COG0437	4 iron, 4 sulfur cluster binding
VP1929	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VP1933	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VP1934	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VP1935	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VP1940	COG0019	diaminopimelate decarboxylase activity
VP1944	COG0322	excinuclease ABC activity
VP1945	COG2197	response regulator
VP1946	COG0417	DNA replication proofreading
VP1948	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VP1949	COG3099	Belongs to the UPF0263 family
VP1951	COG1187	pseudouridine synthase activity
VP1953	COG0009	L-threonylcarbamoyladenylate synthase
VP1954	COG0613	PHP domain protein
VP1956	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VP1957	COG0512	Glutamine amidotransferase of anthranilate synthase
VP1958	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VP1959	COG0135	phosphoribosylanthranilate isomerase activity
VP1959	COG0134	indole-3-glycerol-phosphate synthase activity
VP1960	COG0133	tryptophan synthase activity
VP1961	COG0159	tryptophan synthase activity
VP1962	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VP1964	COG0318	PFAM AMP-dependent synthetase and ligase
VP1966	COG1301	dicarboxylic acid transport
VP1970	COG2917	probably involved in intracellular septation
VP1972	COG2350	Protein conserved in bacteria
VP1974	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VP1976	COG0583	DNA-binding transcription factor activity
VP1979	COG3706	GGDEF domain
VP1979	COG5001	Diguanylate cyclase
VP1979	COG4251	negative regulation of phosphorylation
VP1979	COG2203	Gaf domain
VP1980	COG1032	radical SAM domain protein
VP1981	COG0840	transmembrane signaling receptor activity
VP1983	COG0745	RESPONSE REGULATOR receiver
VP1984	COG5002	protein histidine kinase activity
VP1984	COG3850	Histidine kinase
VP1993	COG2207	Transcriptional regulator
VP1993	COG1917	Cupin 2, conserved barrel domain protein
VP1994	COG1335	isochorismatase
VP1995	COG0577	efflux transmembrane transporter activity
VP1995	COG1136	(ABC) transporter
VP1996	COG1136	(ABC) transporter
VP1996	COG0577	efflux transmembrane transporter activity
VP1997	COG0577	efflux transmembrane transporter activity
VP1997	COG1136	(ABC) transporter
VP1999	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VP2005	COG3118	belongs to the thioredoxin family
VP2006	COG4232	protein-disulfide reductase activity
VP2015	COG2863	cytochrome
VP2016	COG3258	Cytochrome c
VP2017	COG2995	paraquat-inducible protein a
VP2018	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VP2018	COG3008	intermembrane lipid transfer
VP2020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VP2025	COG4166	transmembrane transport
VP2026	COG0284	orotidine-5'-phosphate decarboxylase activity
VP2027	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VP2028	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VP2030	COG0539	negative regulation of cytoplasmic translation
VP2031	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VP2032	COG0616	signal peptide processing
VP2033	COG1028	Short-chain dehydrogenase reductase Sdr
VP2036	COG0587	DNA-directed DNA polymerase activity
VP2037	COG0835	chemotaxis
VP2037	COG0784	Response regulator, receiver
VP2038	COG1940	carbohydrate kinase activity
VP2039	COG0469	pyruvate kinase activity
VP2040	COG4667	esterase of the alpha-beta hydrolase superfamily
VP2043	COG0733	neurotransmitter:sodium symporter activity
VP2046	COG1263	PTS System
VP2046	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VP2047	COG0084	hydrolase, TatD family'
VP2049	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VP2050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VP2056	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VP2057	COG0416	fatty acid biosynthetic process
VP2059	COG1399	metal-binding, possibly nucleic acid-binding protein
VP2060	COG0424	maF-like protein
VP2061	COG0564	pseudouridine synthase activity
VP2062	COG1530	ribonuclease E activity
VP2063	COG0659	secondary active sulfate transmembrane transporter activity
VP2064	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VP2065	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VP2067	COG0572	uridine kinase
VP2068	COG0489	protein tyrosine kinase activity
VP2069	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VP2069	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VP2071	COG2186	Transcriptional regulator
VP2072	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VP2073	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VP2074	COG0653	protein targeting
VP2075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VP2077	COG0366	Alpha amylase catalytic
VP2078	COG1122	ATPase activity
VP2079	COG4120	Belongs to the binding-protein-dependent transport system permease family
VP2081	COG3092	negative regulation of chromosome organization
VP2082	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VP2083	COG0280	phosphate acetyltransferase
VP2083	COG0857	belongs to the CobB CobQ family
VP2084	COG3174	membrane
VP2086	COG0435	Glutathione S-transferase
VP2088	COG0444	Belongs to the ABC transporter superfamily
VP2089	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VP2090	COG0601	transmembrane transport
VP2092	COG0314	molybdopterin synthase activity
VP2093	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VP2094	COG0315	cyclic pyranopterin monophosphate synthase activity
VP2095	COG0521	Mo-molybdopterin cofactor biosynthetic process
VP2096	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VP2097	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VP2098	COG2198	Histidine kinase
VP2099	COG2204	response regulator
VP2100	COG0556	nucleotide-excision repair
VP2102	COG4657	Part of a membrane complex involved in electron transport
VP2103	COG2878	Part of a membrane complex involved in electron transport
VP2104	COG4656	Part of a membrane complex involved in electron transport
VP2105	COG4658	electron transport chain
VP2106	COG4659	FMN binding
VP2107	COG4660	Part of a membrane complex involved in electron transport
VP2108	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VP2109	COG0346	lactoylglutathione lyase activity
VP2111	COG2885	chlorophyll binding
VP2114	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VP2115	COG2056	Na+-H+ antiporter family
VP2117	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VP2121	COG1012	belongs to the aldehyde dehydrogenase family
VP2121	COG1454	alcohol dehydrogenase
VP2122	COG2095	MarC family integral membrane protein
VP2123	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VP2124	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VP2125	COG1757	Na H antiporter
VP2128	COG3081	Nucleoid-associated protein
VP2129	COG3082	Protein of unknown function (DUF1414)
VP2130	COG3083	sulfuric ester hydrolase activity
VP2131	COG0582	viral genome integration into host DNA
VP2145	COG0123	including yeast histone deacetylase and acetoin utilization protein
VP2149	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VP2150	COG0778	Nitroreductase
VP2151	COG0446	pyridine nucleotide-disulphide oxidoreductase
VP2151	COG1902	pentaerythritol trinitrate reductase activity
VP2152	COG0616	signal peptide processing
VP2153	COG0252	asparaginase activity
VP2154	COG3139	Protein of unknown function (DUF1315)
VP2156	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VP2157	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VP2160	COG2226	methyltransferase
VP2163	COG1785	Belongs to the alkaline phosphatase family
VP2166	COG0346	lactoylglutathione lyase activity
VP2167	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VP2168	COG0668	transmembrane transport
VP2169	COG2983	Belongs to the UPF0260 family
VP2170	COG2261	transglycosylase associated protein
VP2173	COG3681	Belongs to the UPF0597 family
VP2174	COG0251	oxidation-reduction process
VP2175	COG0814	amino acid
VP2176	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VP2177	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VP2178	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VP2180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VP2181	COG2832	Protein of unknown function (DUF454)
VP2183	COG0745	RESPONSE REGULATOR receiver
VP2184	COG0583	DNA-binding transcription factor activity
VP2185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VP2186	COG1286	toxin biosynthetic process
VP2187	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VP2188	COG0285	dihydrofolate synthase activity
VP2189	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VP2190	COG0101	tRNA pseudouridine synthase activity
VP2192	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VP2193	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VP2194	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VP2195	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VP2195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VP2197	COG0431	NADPH-dependent FMN reductase
VP2199	COG3101	peptidyl-lysine hydroxylation
VP2201	COG2860	membrane
VP2202	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VP2203	COG2890	protein-(glutamine-N5) methyltransferase activity
VP2204	COG2840	Smr protein MutS2
VP2205	COG2062	phosphohistidine phosphatase, SixA
VP2208	COG1024	Enoyl-CoA hydratase
VP2208	COG1250	3-hydroxyacyl-CoA dehydrogenase
VP2209	COG0183	Belongs to the thiolase family
VP2212	COG2067	long-chain fatty acid transport protein
VP2214	COG2853	Lipoprotein
VP2217	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VP2218	COG1138	Cytochrome C-type biogenesis protein
VP2219	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VP2220	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VP2221	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VP2222	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VP2223	COG4133	protoheme IX ABC transporter activity
VP2225	COG0835	chemotaxis
VP2227	COG1192	Involved in chromosome partitioning
VP2228	COG2201	protein-glutamate methylesterase activity
VP2229	COG0784	Response regulator, receiver
VP2229	COG0643	Histidine kinase
VP2229	COG2198	Histidine kinase
VP2230	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VP2237	COG1684	flagellar biosynthetic protein fliR
VP2238	COG1987	bacterial-type flagellum assembly
VP2248	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VP2250	COG1677	Flagellar hook-basal body complex protein FliE
VP2254	COG1516	flagellar protein fliS
VP2256	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VP2257	COG1334	flagellar protein FlaG
VP2258	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VP2259	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VP2261	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VP2262	COG2837	iron assimilation
VP2268	COG1393	Belongs to the ArsC family
VP2269	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VP2272	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VP2273	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VP2274	COG2716	regulation of RNA biosynthetic process
VP2275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VP2278	COG4783	chaperone-mediated protein folding
VP2279	COG1393	Belongs to the ArsC family
VP2283	COG2233	PERMEase
VP2284	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VP2285	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VP2286	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VP2287	COG0121	glutamine amidotransferase
VP2288	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VP2289	COG1960	acyl-CoA dehydrogenase activity
VP2292	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VP2293	COG0328	RNA-DNA hybrid ribonuclease activity
VP2294	COG2226	methyltransferase
VP2295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VP2296	COG0741	lytic transglycosylase activity
VP2296	COG1388	LysM domain
VP2298	COG3021	interspecies interaction between organisms
VP2299	COG0347	Belongs to the P(II) protein family
VP2301	COG0037	tRNA processing
VP2302	COG0825	malonyl-CoA metabolic process
VP2303	COG0587	DNA-directed DNA polymerase activity
VP2304	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VP2305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VP2306	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VP2307	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VP2308	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VP2309	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VP2311	COG0750	zinc metalloprotease
VP2312	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VP2313	COG0575	Belongs to the CDS family
VP2314	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VP2315	COG0233	cytoplasmic translational termination
VP2316	COG0528	UMP kinase activity
VP2317	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VP2318	COG0052	Belongs to the universal ribosomal protein uS2 family
VP2319	COG0024	Methionine aminopeptidase
VP2320	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VP2322	COG0564	pseudouridine synthase activity
VP2323	COG3098	single-species biofilm formation
VP2328	COG1671	Belongs to the UPF0178 family
VP2329	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VP2331	COG0254	rRNA binding
VP2332	COG1720	tRNA m6t6A37 methyltransferase activity
VP2333	COG0442	prolyl-tRNA aminoacylation
VP2337	COG0733	neurotransmitter:sodium symporter activity
VP2340	COG0514	ATP-dependent DNA helicase (RecQ)
VP2341	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VP2342	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VP2345	COG1477	protein flavinylation
VP2346	COG2871	sodium ion transport
VP2347	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VP2348	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VP2349	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VP2350	COG1805	sodium ion transport
VP2351	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VP2352	COG0271	Belongs to the BolA IbaG family
VP2353	COG2813	Specifically methylates the guanine in position
VP2354	COG3056	Lipoprotein
VP2358	COG1595	DNA-templated transcription, initiation
VP2362	COG3248	Nucleoside-binding outer membrane protein
VP2363	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VP2364	COG0693	protein deglycase activity
VP2365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VP2366	COG3706	GGDEF domain
VP2367	COG2166	iron-sulfur cluster assembly
VP2368	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VP2369	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VP2371	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VP2371	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VP2373	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VP2374	COG1074	ATP-dependent DNA helicase activity
VP2375	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VP2379	COG3141	response to X-ray
VP2380	COG2171	N-acyltransferase activity
VP2381	COG0584	glycerophosphoryl diester phosphodiesterase
VP2382	COG2271	Major facilitator Superfamily
VP2385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VP2386	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VP2387	COG1349	DNA-binding transcription factor activity
VP2388	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VP2389	COG0598	Magnesium transport protein CorA
VP2392	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VP2393	COG1609	Transcriptional regulator
VP2394	COG2211	Major facilitator Superfamily
VP2396	COG1609	Transcriptional regulator
VP2397	COG2017	converts alpha-aldose to the beta-anomer
VP2398	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VP2400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VP2402	COG1609	Transcriptional regulator
VP2403	COG3250	beta-galactosidase activity
VP2404	COG2731	YhcH YjgK YiaL family protein
VP2405	COG0531	amino acid
VP2406	COG0583	DNA-binding transcription factor activity
VP2419	COG4964	Belongs to the GSP D family
VP2424	COG2169	Transcriptional regulator
VP2425	COG1022	Amp-dependent synthetase and ligase
VP2427	COG0583	DNA-binding transcription factor activity
VP2428	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VP2429	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VP2431	COG0560	Phosphoserine phosphatase
VP2433	COG0813	purine-nucleoside phosphorylase activity
VP2434	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VP2435	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VP2436	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VP2437	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VP2439	COG0084	hydrolase, TatD family'
VP2440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VP2444	COG3153	acetyltransferase
VP2445	COG3154	lipid carrier protein
VP2447	COG0826	peptidase U32
VP2448	COG0826	peptidase U32
VP2449	COG0534	Mate efflux family protein
VP2452	COG1185	polyribonucleotide nucleotidyltransferase activity
VP2453	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VP2454	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VP2455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VP2456	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VP2457	COG0195	Participates in both transcription termination and antitermination
VP2458	COG0779	Required for maturation of 30S ribosomal subunits
VP2460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VP2461	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VP2462	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VP2463	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VP2464	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VP2465	COG1534	Rna-binding protein
VP2466	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VP2467	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VP2468	COG2027	D-alanyl-D-alanine carboxypeptidase
VP2470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VP2471	COG0739	heme binding
VP2472	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VP2474	COG0316	Belongs to the HesB IscA family
VP2475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VP2476	COG0628	permease
VP2477	COG2813	Specifically methylates the guanine in position
VP2478	COG2205	protein histidine kinase activity
VP2478	COG2198	Histidine kinase
VP2478	COG0784	Response regulator, receiver
VP2478	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VP2479	COG0747	negative chemotaxis
VP2481	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VP2482	COG0444	Belongs to the ABC transporter superfamily
VP2483	COG4608	Belongs to the ABC transporter superfamily
VP2485	COG2971	BadF BadG BcrA BcrD
VP2488	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VP2489	COG3842	ATPase activity
VP2491	COG1840	ABC-type Fe3 transport system, periplasmic component
VP2492	COG0004	ammonium transporteR
VP2494	COG3112	Uncharacterised protein family (UPF0231)
VP2495	COG1049	propionate catabolic process, 2-methylcitrate cycle
VP2496	COG1752	Esterase of the alpha-beta hydrolase superfamily
VP2497	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VP2498	COG1643	Atp-dependent helicase
VP2499	COG1489	DNA binding
VP2502	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VP2505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VP2506	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VP2507	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VP2509	COG1560	Kdo2-lipid A biosynthetic process
VP2510	COG0842	Transport permease protein
VP2511	COG1131	(ABC) transporter
VP2513	COG0659	secondary active sulfate transmembrane transporter activity
VP2514	COG0288	reversible hydration of carbon dioxide
VP2517	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VP2518	COG0508	dehydrogenase complex catalyzes the overall conversion of
VP2519	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VP2520	COG2186	Transcriptional regulator
VP2522	COG0157	Belongs to the NadC ModD family
VP2524	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VP2525	COG1459	type II secretion system
VP2527	COG0237	dephospho-CoA kinase activity
VP2528	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VP2529	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VP2530	COG0335	large ribosomal subunit rRNA binding
VP2531	COG0336	Belongs to the RNA methyltransferase TrmD family
VP2532	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VP2533	COG0228	four-way junction DNA binding
VP2534	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VP2535	COG4137	Cytochrome C assembly protein
VP2536	COG4536	flavin adenine dinucleotide binding
VP2537	COG1854	S-ribosylhomocysteine lyase activity
VP2539	COG2918	glutathione biosynthetic process
VP2540	COG0612	Peptidase, M16
VP2541	COG1238	metal cluster binding
VP2543	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VP2544	COG5016	pyruvate
VP2544	COG0511	ligase activity, forming carbon-carbon bonds
VP2545	COG3630	sodium ion export across plasma membrane
VP2547	COG0527	aspartate kinase activity
VP2548	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VP2549	COG2137	regulation of response to DNA damage stimulus
VP2550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VP2551	COG1546	Belongs to the CinA family
VP2552	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VP2553	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VP2555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VP2556	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VP2557	COG0585	pseudouridine synthase activity
VP2558	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VP2559	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VP2560	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VP2561	COG0148	phosphopyruvate hydratase activity
VP2562	COG0504	CTP synthase activity
VP2563	COG3956	TIGRFAM MazG family protein
VP2564	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VP2566	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VP2568	COG0736	holo-[acyl-carrier-protein] synthase activity
VP2569	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VP2570	COG1381	Involved in DNA repair and RecF pathway recombination
VP2571	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VP2572	COG0571	ribonuclease III activity
VP2574	COG0481	GTPase activity
VP2575	COG3086	response to oxidative stress
VP2577	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VP2578	COG1595	DNA-templated transcription, initiation
VP2580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VP2582	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VP2583	COG0354	folic acid binding
VP2586	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VP2587	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VP2588	COG3079	Belongs to the UPF0149 family
VP2590	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VP2591	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VP2592	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VP2593	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VP2595	COG0583	DNA-binding transcription factor activity
VP2597	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VP2598	COG0668	transmembrane transport
VP2599	COG0191	fructose-bisphosphate aldolase activity
VP2600	COG0126	phosphoglycerate kinase activity
VP2601	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VP2602	COG4771	TonB-dependent receptor
VP2603	COG0583	DNA-binding transcription factor activity
VP2605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VP2606	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VP2608	COG3091	SprT-like family
VP2609	COG2356	endonuclease I
VP2610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VP2611	COG0189	ligase activity
VP2612	COG1678	Uncharacterized ACR, COG1678
VP2613	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VP2616	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VP2617	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VP2618	COG0762	integral membrane protein
VP2619	COG1872	DUF167
VP2621	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VP2622	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VP2623	COG2066	Belongs to the glutaminase family
VP2625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VP2627	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VP2628	COG0741	lytic transglycosylase activity
VP2629	COG0840	transmembrane signaling receptor activity
VP2630	COG1012	belongs to the aldehyde dehydrogenase family
VP2631	COG3437	response regulator, receiver
VP2633	COG3394	polysaccharide catabolic process
VP2634	COG1486	melibiose metabolic process
VP2635	COG1447	Phosphotransferase system cellobiose-specific component IIA
VP2636	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VP2637	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VP2638	COG0726	polysaccharide deacetylase
VP2639	COG1028	Short-chain dehydrogenase reductase Sdr
VP2642	COG0795	lipopolysaccharide-transporting ATPase activity
VP2643	COG0795	lipopolysaccharide-transporting ATPase activity
VP2644	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VP2645	COG2927	DNA polymerase III (CHI subunit)
VP2646	COG0525	valine-tRNA ligase activity
VP2652	COG2235	arginine
VP2653	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VP2654	COG0540	Belongs to the ATCase OTCase family
VP2655	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VP2656	COG0251	oxidation-reduction process
VP2657	COG0204	Acyl-transferase
VP2658	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VP2659	COG5007	Belongs to the BolA IbaG family
VP2661	COG2854	intermembrane phospholipid transfer
VP2662	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VP2663	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VP2664	COG1127	ABC transporter
VP2666	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VP2666	COG0517	IMP dehydrogenase activity
VP2668	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VP2669	COG1137	ATPase activity
VP2671	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VP2672	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VP2673	COG1660	Displays ATPase and GTPase activities
VP2674	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VP2675	COG2239	Acts as a magnesium transporter
VP2676	COG0312	modulator of DNA gyrase
VP2677	COG3028	Belongs to the UPF0307 family
VP2678	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VP2679	COG0564	pseudouridine synthase activity
VP2682	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VP2683	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VP2684	COG0312	modulator of DNA gyrase
VP2685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VP2686	COG3164	Protein of unknown function
VP2688	COG0424	maF-like protein
VP2689	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VP2690	COG1792	Involved in formation and maintenance of cell shape
VP2691	COG1077	Cell shape determining protein MreB Mrl
VP2698	COG2165	general secretion pathway protein
VP2700	COG1459	type II secretion system
VP2701	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VP2703	COG3267	Type II secretory pathway component ExeA
VP2703	COG3409	Peptidoglycan-binding domain 1 protein
VP2708	COG2199	diguanylate cyclase activity
VP2708	COG2200	EAL domain
VP2709	COG0629	single-stranded DNA binding
VP2712	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VP2714	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VP2715	COG0527	aspartate kinase activity
VP2717	COG0646	methionine synthase
VP2717	COG1410	methionine synthase
VP2720	COG0175	sulfate reduction
VP2721	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VP2722	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VP2727	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VP2729	COG0735	belongs to the Fur family
VP2731	COG0166	Belongs to the GPI family
VP2732	COG0432	Pfam Uncharacterised protein family UPF0047
VP2734	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VP2737	COG0359	binds to the 23S rRNA
VP2739	COG2965	DNA replication, synthesis of RNA primer
VP2740	COG0360	Binds together with S18 to 16S ribosomal RNA
VP2741	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VP2742	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VP2744	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VP2745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VP2751	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VP2753	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VP2753	COG0678	peroxiredoxin activity
VP2756	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VP2756	COG0165	Argininosuccinate lyase
VP2757	COG0137	argininosuccinate synthase activity
VP2758	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VP2759	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VP2760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VP2761	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VP2763	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VP2764	COG0460	homoserine dehydrogenase
VP2764	COG0527	aspartate kinase activity
VP2765	COG0626	cystathionine gamma-synthase activity
VP2767	COG0281	malic enzyme
VP2769	COG2906	2 iron, 2 sulfur cluster binding
VP2770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VP2771	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VP2772	COG0049	tRNA binding
VP2774	COG2168	tRNA wobble position uridine thiolation
VP2775	COG2923	Belongs to the DsrF TusC family
VP2776	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VP2777	COG2964	Protein conserved in bacteria
VP2778	COG0545	Peptidyl-prolyl cis-trans isomerase
VP2780	COG2900	Belongs to the SlyX family
VP2781	COG1446	asparaginase
VP2783	COG1047	Peptidyl-prolyl cis-trans
VP2786	COG2249	NAD(P)H dehydrogenase (quinone) activity
VP2788	COG0488	(ABC) transporter
VP2790	COG0429	hydrolase of the alpha beta-hydrolase fold
VP2791	COG3089	Belongs to the UPF0270 family
VP2792	COG3954	Phosphoribulokinase
VP2793	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VP2795	COG1012	belongs to the aldehyde dehydrogenase family
VP2797	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VP2798	COG0512	Glutamine amidotransferase of anthranilate synthase
VP2804	COG0180	Tryptophanyl-tRNA synthetase
VP2805	COG0546	phosphoglycolate phosphatase activity
VP2806	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VP2807	COG0557	exoribonuclease II activity
VP2808	COG1959	2 iron, 2 sulfur cluster binding
VP2809	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VP2809	COG1017	nitric oxide dioxygenase activity
VP2811	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VP2812	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VP2813	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VP2814	COG0330	HflC and HflK could
VP2815	COG0330	HflC and HflK could
VP2816	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VP2818	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VP2819	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VP2820	COG0860	N-Acetylmuramoyl-L-alanine amidase
VP2821	COG0802	atpase or kinase
VP2822	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VP2823	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VP2824	COG1162	GTPase activity
VP2825	COG0688	phosphatidylethanolamine metabolic process
VP2826	COG0471	metal ion transport
VP2827	COG0840	transmembrane signaling receptor activity
VP2829	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VP2830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VP2831	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VP2832	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VP2833	COG1045	serine acetyltransferase
VP2834	COG4942	peptidase
VP2838	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VP2840	COG1053	succinate dehydrogenase
VP2841	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VP2842	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VP2843	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VP2845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VP2846	COG1509	lysine 2,3-aminomutase activity
VP2848	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VP2851	COG0459	protein refolding
VP2853	COG0534	Mate efflux family protein
VP2855	COG0205	6-phosphofructokinase activity
VP2857	COG3678	ATP-independent chaperone mediated protein folding
VP2858	COG0745	RESPONSE REGULATOR receiver
VP2859	COG2205	protein histidine kinase activity
VP2861	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VP2862	COG3030	protein affecting phage T7 exclusion by the F plasmid
VP2863	COG1027	Aspartate ammonia-lyase
VP2864	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VP2865	COG4232	protein-disulfide reductase activity
VP2867	COG3263	regulation of cellular component size
VP2869	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VP2874	COG2205	protein histidine kinase activity
VP2874	COG0784	Response regulator, receiver
VP2875	COG2814	Major facilitator Superfamily
VP2878	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VP2879	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VP2880	COG0511	ligase activity, forming carbon-carbon bonds
VP2881	COG0439	Biotin carboxylase
VP2883	COG2264	protein methyltransferase activity
VP2884	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VP2885	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VP2886	COG2814	Major facilitator Superfamily
VP2887	COG0488	(ABC) transporter
VP2888	COG3706	GGDEF domain
VP2890	COG1982	Orn Lys Arg decarboxylase major
VP2891	COG0531	amino acid
VP2893	COG3710	Transcriptional regulator
VP2894	COG0789	Transcriptional regulator
VP2896	COG0138	bifunctional purine biosynthesis protein purh
VP2898	COG0151	Belongs to the GarS family
VP2912	COG1253	flavin adenine dinucleotide binding
VP2914	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VP2915	COG1573	uracil-dna glycosylase
VP2916	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VP2919	COG2816	NAD+ diphosphatase activity
VP2920	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VP2921	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VP2922	COG0085	RNA polymerase activity
VP2923	COG0222	ribosome binding
VP2924	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VP2925	COG0081	regulation of translation
VP2926	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VP2927	COG0250	Participates in transcription elongation, termination and antitermination
VP2928	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VP2930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VP2932	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VP2934	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VP2936	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VP2938	COG4206	TonB-dependent receptor
VP2939	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VP2942	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VP2943	COG0534	Mate efflux family protein
VP2944	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VP2945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VP2947	COG2937	Belongs to the GPAT DAPAT family
VP2948	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VP2949	COG3161	chorismate lyase activity
VP2950	COG1580	Controls the rotational direction of flagella during chemotaxis
VP2951	COG0705	Rhomboid family
VP2952	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VP2954	COG2177	Part of the ABC transporter FtsEX involved in
VP2955	COG2884	Cell division ATP-binding protein ftsE
VP2956	COG0552	protein localization to endoplasmic reticulum
VP2957	COG0742	ribosomal rna small subunit methyltransferase
VP2959	COG2095	MarC family integral membrane protein
VP2970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VP2971	COG0640	Transcriptional regulator
VP2972	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VP2973	COG1280	lysine exporter protein (LysE YggA)
VP2974	COG2267	carboxylic ester hydrolase activity
VP2975	COG0561	phosphatase activity
VP2978	COG3148	PFAM DTW domain containing protein
VP2979	COG2199	diguanylate cyclase activity
VP2979	COG2200	EAL domain
VP2979	COG3287	FIST C domain
VP2980	COG1011	Hydrolase
VP2981	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VP2983	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VP2984	COG0019	diaminopimelate decarboxylase activity
VP2986	COG1965	Belongs to the frataxin family
VP2987	COG3072	Adenylate cyclase
VP2988	COG0181	hydroxymethylbilane synthase activity
VP2989	COG1587	Uroporphyrinogen-III synthase
VP2990	COG2959	enzyme of heme biosynthesis
VP2991	COG3071	HemY protein
VP2996	COG0633	Ferredoxin
VP2997	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VP3001	COG3118	belongs to the thioredoxin family
VP3002	COG0513	Belongs to the DEAD box helicase family
VP3003	COG0248	Ppx GppA phosphatase
VP3004	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VP3007	COG0514	ATP-dependent DNA helicase (RecQ)
VP3008	COG2962	Rard protein
VP3010	COG1280	lysine exporter protein (LysE YggA)
VP3011	COG0405	Gamma-glutamyltransferase
VP3013	COG0210	DNA helicase
VP3015	COG3220	belongs to the UPF0276 family
VP3021	COG0006	proline dipeptidase activity
VP3021	COG0006	proline dipeptidase activity
VP3023	COG2022	thiamine diphosphate biosynthetic process
VP3024	COG2104	thiamine diphosphate biosynthetic process
VP3025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VP3026	COG0352	thiamine-phosphate diphosphorylase activity
VP3027	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VP3028	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VP3031	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VP3033	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VP3034	COG0408	coproporphyrinogen oxidase activity
VP3035	COG0009	L-threonylcarbamoyladenylate synthase
VP3036	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VP3037	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VP3038	COG0551	DNA topoisomerase type I activity
VP3039	COG2922	Belongs to the Smg family
VP3040	COG0758	DNA mediated transformation
VP3042	COG0242	peptide deformylase activity
VP3043	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VP3044	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VP3044	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VP3045	COG0569	domain protein
VP3046	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VP3048	COG1272	protein, Hemolysin III
VP3049	COG4326	sporulation control protein
VP3051	COG3084	Protein conserved in bacteria
VP3053	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VP3054	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VP3055	COG0204	Acyl-transferase
VP3057	COG0606	chelatase, subunit chli
VP3059	COG3978	acetolactate synthase activity
VP3060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VP3061	COG0129	dihydroxy-acid dehydratase activity
VP3063	COG0583	DNA-binding transcription factor activity
VP3064	COG2814	Major facilitator Superfamily
VP3065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VP3066	COG0765	amino acid transport
VP3067	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VP3068	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VP3069	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VP3070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VP3071	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VP3072	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VP3075	COG0356	it plays a direct role in the translocation of protons across the membrane
VP3076	COG3312	ion transport
VP3077	COG1475	DNA binding
VP3078	COG1192	Involved in chromosome partitioning
VP3079	COG0357	Ribosomal RNA small subunit methyltransferase G
VP3080	COG0445	tRNA wobble uridine modification
VPA0002	COG0706	membrane insertase activity
VPA0023	COG0751	glycine-tRNA ligase activity
VPA0120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPA0120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPA0121	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPA0121	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPA0130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VPA0132	COG5001	Diguanylate cyclase
VPA0132	COG3300	MHYT domain
VPA0133	COG5001	Diguanylate cyclase
VPA0133	COG3300	MHYT domain
VPA0135	COG2204	response regulator
VPA0137	COG3852	Histidine kinase
VPA0144	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VPA0172	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VPA0220	COG1519	Transferase
VPA0312	COG0163	prenyltransferase activity
VPA0326	COG0039	L-malate dehydrogenase activity
VPA0340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VPA0355	COG1022	Amp-dependent synthetase and ligase
VPA0426	COG0306	phosphate transporter
VPA0428	COG3025	triphosphatase activity
VPA0435	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VPA0438	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VPA0438	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VPA0452	COG2857	Cytochrome c1
VPA0463	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VPA0489	COG0070	glutamate synthase
VPA0489	COG0069	glutamate synthase activity
VPA0489	COG0067	glutamate synthase
VPA0491	COG0069	glutamate synthase activity
VPA0491	COG0070	glutamate synthase
VPA0491	COG0067	glutamate synthase
VPA0514	COG0513	Belongs to the DEAD box helicase family
VPA0520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VPA0578	COG0542	response to heat
VPA0580	COG0542	response to heat
VPA0631	COG1160	GTP binding
VPA0719	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VPA0742	COG0012	GTP binding
VPA0770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPA0797	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPA0855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VPA0858	COG0018	arginyl-trna synthetase
VPA0911	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VPA0934	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VPA0984	COG2719	SpoVR family
VPA1013	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VPA1142	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPA1226	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VPA1244	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VPA1278	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VPA1279	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VPA1293	COG0072	phenylalanine-tRNA ligase activity
VPA1293	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPA1304	COG1823	symporter activity
VPA1315	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VPA1428	COG0515	serine threonine protein kinase
VPA1472	COG0438	transferase activity, transferring glycosyl groups
VPA1557	COG0784	Response regulator, receiver
VPA1557	COG2205	protein histidine kinase activity
VPA1587	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPA1596	COG2902	Dehydrogenase
VPA1600	COG0308	aminopeptidase N
VPA1606	COG1956	GAF domain-containing protein
VPA1719	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPA1737	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VPA1740	COG0531	amino acid
VPAt06	COG1560	Kdo2-lipid A biosynthetic process