locus-tag	class	description
H5404_RS00035	COG1120	ATPase activity
H5404_RS00040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5404_RS00045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5404_RS00050	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H5404_RS00055	COG4772	TonB-dependent receptor
H5404_RS00080	COG4264	IucA IucC family
H5404_RS00085	COG0019	diaminopimelate decarboxylase activity
H5404_RS00090	COG1653	transport
H5404_RS00115	COG0826	peptidase U32
H5404_RS00120	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5404_RS00125	COG1129	ABC transporter
H5404_RS00130	COG1879	ABC-type sugar transport system periplasmic component
H5404_RS00135	COG1069	ribulokinase activity
H5404_RS00145	COG2160	L-arabinose isomerase activity
H5404_RS00170	COG1764	response to oxidative stress
H5404_RS00175	COG1846	Transcriptional regulator
H5404_RS00185	COG3634	alkyl hydroperoxide reductase activity
H5404_RS00220	COG1595	DNA-templated transcription, initiation
H5404_RS00235	COG0583	DNA-binding transcription factor activity
H5404_RS00240	COG1486	melibiose metabolic process
H5404_RS00255	COG2258	MOSC domain
H5404_RS00260	COG0513	Belongs to the DEAD box helicase family
H5404_RS00275	COG2207	Transcriptional regulator
H5404_RS00285	COG1132	(ABC) transporter
H5404_RS00330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5404_RS00355	COG0259	pyridoxamine-phosphate oxidase activity
H5404_RS00405	COG4166	transmembrane transport
H5404_RS00420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H5404_RS00425	COG1263	PTS System
H5404_RS00425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5404_RS00430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H5404_RS00435	COG3340	Belongs to the peptidase S51 family
H5404_RS00455	COG1444	tRNA N-acetyltransferase activity
H5404_RS00480	COG4608	Belongs to the ABC transporter superfamily
H5404_RS00485	COG0444	Belongs to the ABC transporter superfamily
H5404_RS00495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5404_RS00495	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H5404_RS00515	COG0217	transcriptional regulatory protein
H5404_RS00520	COG0772	Belongs to the SEDS family
H5404_RS00530	COG1136	(ABC) transporter
H5404_RS00550	COG3275	phosphorelay sensor kinase activity
H5404_RS00555	COG3279	Response regulator of the LytR AlgR family
H5404_RS00565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5404_RS00590	COG0786	glutamate:sodium symporter activity
H5404_RS00600	COG1131	(ABC) transporter
H5404_RS00605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5404_RS00610	COG0786	glutamate:sodium symporter activity
H5404_RS00620	COG0363	glucosamine-6-phosphate deaminase activity
H5404_RS00640	COG1741	Belongs to the pirin family
H5404_RS00645	COG2259	Doxx family
H5404_RS00655	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H5404_RS00660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5404_RS00670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5404_RS00710	COG3123	guanosine phosphorylase activity
H5404_RS00720	COG5001	Diguanylate cyclase
H5404_RS00725	COG0534	Mate efflux family protein
H5404_RS00730	COG0564	pseudouridine synthase activity
H5404_RS00745	COG0583	DNA-binding transcription factor activity
H5404_RS00750	COG0561	phosphatase activity
H5404_RS00760	COG2199	diguanylate cyclase activity
H5404_RS00775	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H5404_RS00780	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H5404_RS00785	COG0583	DNA-binding transcription factor activity
H5404_RS00800	COG1414	Transcriptional regulator
H5404_RS00805	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS00815	COG1917	Cupin 2, conserved barrel domain protein
H5404_RS00830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5404_RS00835	COG0800	Aldolase
H5404_RS00855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5404_RS00860	COG0823	Involved in the tonB-independent uptake of proteins
H5404_RS00865	COG2375	cellular response to nickel ion
H5404_RS00895	COG1357	PFAM Pentapeptide repeats (8 copies)
H5404_RS00900	COG3047	cAMP biosynthetic process
H5404_RS00930	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H5404_RS00930	COG3408	Glycogen debranching enzyme
H5404_RS00935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H5404_RS00945	COG0583	DNA-binding transcription factor activity
H5404_RS00955	COG0583	DNA-binding transcription factor activity
H5404_RS00970	COG0546	phosphoglycolate phosphatase activity
H5404_RS00995	COG3835	regulator
H5404_RS01000	COG2610	gluconate transmembrane transporter activity
H5404_RS01005	COG1929	Belongs to the glycerate kinase type-1 family
H5404_RS01010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5404_RS01030	COG0456	acetyltransferase
H5404_RS01045	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS01055	COG3005	denitrification pathway
H5404_RS01060	COG0243	molybdopterin cofactor binding
H5404_RS01070	COG0352	thiamine-phosphate diphosphorylase activity
H5404_RS01075	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H5404_RS01080	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5404_RS01085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5404_RS01090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5404_RS01095	COG1116	anion transmembrane transporter activity
H5404_RS01100	COG0351	phosphomethylpyrimidine kinase
H5404_RS01105	COG0312	modulator of DNA gyrase
H5404_RS01110	COG0312	modulator of DNA gyrase
H5404_RS01115	COG1901	pseudouridine methyltransferase
H5404_RS01170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5404_RS01180	COG0584	glycerophosphoryl diester phosphodiesterase
H5404_RS01185	COG0039	L-malate dehydrogenase activity
H5404_RS01190	COG0745	RESPONSE REGULATOR receiver
H5404_RS01210	COG0811	peptide transport
H5404_RS01215	COG0811	peptide transport
H5404_RS01220	COG0848	biopolymer transport protein
H5404_RS01260	COG0803	Belongs to the bacterial solute-binding protein 9 family
H5404_RS01265	COG1121	(ABC) transporter
H5404_RS01270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5404_RS01285	COG1770	oligopeptidase
H5404_RS01290	COG2814	Major facilitator Superfamily
H5404_RS01295	COG0010	Belongs to the arginase family
H5404_RS01300	COG1166	arginine decarboxylase activity
H5404_RS01310	COG4067	protein conserved in archaea
H5404_RS01310	COG0189	ligase activity
H5404_RS01315	COG0189	ligase activity
H5404_RS01325	COG0583	DNA-binding transcription factor activity
H5404_RS01365	COG2199	diguanylate cyclase activity
H5404_RS01370	COG1114	Component of the transport system for branched-chain amino acids
H5404_RS01385	COG0579	oxidoreductase
H5404_RS01395	COG3033	Beta-eliminating lyase
H5404_RS01410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5404_RS01425	COG3706	GGDEF domain
H5404_RS01430	COG0840	transmembrane signaling receptor activity
H5404_RS01445	COG3706	GGDEF domain
H5404_RS01450	COG0415	Belongs to the DNA photolyase family
H5404_RS01455	COG3046	protein related to deoxyribodipyrimidine photolyase
H5404_RS01470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5404_RS01470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5404_RS01475	COG1765	OsmC-like protein
H5404_RS01505	COG1765	OsmC-like protein
H5404_RS01510	COG0110	maltose O-acetyltransferase activity
H5404_RS01550	COG1011	Hydrolase
H5404_RS01565	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H5404_RS01575	COG2067	long-chain fatty acid transport protein
H5404_RS01580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_RS01585	COG0577	efflux transmembrane transporter activity
H5404_RS01585	COG1136	(ABC) transporter
H5404_RS01595	COG3240	lipase activity
H5404_RS01625	COG1609	Transcriptional regulator
H5404_RS01630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5404_RS01635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5404_RS01640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5404_RS01645	COG1840	ABC-type Fe3 transport system, periplasmic component
H5404_RS01655	COG3842	ATPase activity
H5404_RS01680	COG2990	Protein conserved in bacteria
H5404_RS01685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5404_RS01690	COG2866	Carboxypeptidase
H5404_RS01700	COG0583	DNA-binding transcription factor activity
H5404_RS01720	COG3104	oligopeptide transport
H5404_RS01725	COG1760	l-serine dehydratase
H5404_RS01745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5404_RS01750	COG0741	lytic transglycosylase activity
H5404_RS01770	COG1815	bacterial-type flagellum-dependent cell motility
H5404_RS01775	COG1558	bacterial-type flagellum-dependent cell motility
H5404_RS01780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H5404_RS01785	COG1749	Flagellar hook protein flgE
H5404_RS01790	COG4787	bacterial-type flagellum-dependent cell motility
H5404_RS01795	COG4786	Flagellar basal body rod
H5404_RS01800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H5404_RS01805	COG1706	bacterial-type flagellum-dependent cell motility
H5404_RS01815	COG1256	bacterial-type flagellum assembly
H5404_RS01815	COG4786	Flagellar basal body rod
H5404_RS01820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_RS01840	COG1304	FMN binding
H5404_RS01865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5404_RS01870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5404_RS01875	COG0459	protein refolding
H5404_RS01890	COG1280	lysine exporter protein (LysE YggA)
H5404_RS01910	COG1309	transcriptional regulator
H5404_RS01920	COG0737	Belongs to the 5'-nucleotidase family
H5404_RS01925	COG2070	2-Nitropropane dioxygenase
H5404_RS01930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_RS01945	COG0346	lactoylglutathione lyase activity
H5404_RS01950	COG1349	DNA-binding transcription factor activity
H5404_RS01960	COG0753	catalase activity
H5404_RS01970	COG1335	isochorismatase
H5404_RS01980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H5404_RS02000	COG0583	DNA-binding transcription factor activity
H5404_RS02015	COG3713	MltA-interacting MipA family protein
H5404_RS02020	COG3015	lipoprotein NlpE involved in copper resistance
H5404_RS02025	COG1342	Belongs to the UPF0251 family
H5404_RS02055	COG4948	Mandelate Racemase Muconate Lactonizing
H5404_RS02065	COG0583	DNA-binding transcription factor activity
H5404_RS02100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5404_RS02130	COG3842	ATPase activity
H5404_RS02160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5404_RS02180	COG3706	GGDEF domain
H5404_RS02200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_RS02220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5404_RS02235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5404_RS02235	COG0574	Belongs to the PEP-utilizing enzyme family
H5404_RS02240	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H5404_RS02245	COG0252	asparaginase activity
H5404_RS02250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5404_RS02255	COG0583	DNA-binding transcription factor activity
H5404_RS02270	COG3122	Protein conserved in bacteria
H5404_RS02280	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS02290	COG1063	alcohol dehydrogenase
H5404_RS02295	COG1902	pentaerythritol trinitrate reductase activity
H5404_RS02310	COG0583	DNA-binding transcription factor activity
H5404_RS02320	COG0513	Belongs to the DEAD box helicase family
H5404_RS02360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5404_RS02365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5404_RS02365	COG2207	Transcriptional regulator
H5404_RS02395	COG2354	Protein conserved in bacteria
H5404_RS02400	COG0418	dihydroorotase activity
H5404_RS02405	COG0401	homolog of Blt101
H5404_RS02410	COG0633	Ferredoxin
H5404_RS02410	COG3217	Mosc domain protein beta barrel domain protein
H5404_RS02410	COG0633	Ferredoxin
H5404_RS02410	COG3217	Mosc domain protein beta barrel domain protein
H5404_RS02415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H5404_RS02420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H5404_RS02460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H5404_RS02465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5404_RS02475	COG0848	biopolymer transport protein
H5404_RS02480	COG0811	peptide transport
H5404_RS02485	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H5404_RS02495	COG3721	Heme iron utilization protein
H5404_RS02500	COG0748	coenzyme F420 binding
H5404_RS02510	COG0835	chemotaxis
H5404_RS02510	COG0784	Response regulator, receiver
H5404_RS02515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5404_RS02535	COG2205	protein histidine kinase activity
H5404_RS02555	COG2814	Major facilitator Superfamily
H5404_RS02570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5404_RS02590	COG3344	reverse transcriptase
H5404_RS02615	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H5404_RS02620	COG0783	Belongs to the Dps family
H5404_RS02625	COG0583	DNA-binding transcription factor activity
H5404_RS02645	COG0641	radical SAM
H5404_RS02660	COG4934	collagen metabolic process
H5404_RS02670	COG0366	Alpha amylase catalytic
H5404_RS02690	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5404_RS02695	COG0589	response to stress
H5404_RS02700	COG0488	(ABC) transporter
H5404_RS02705	COG1505	serine-type exopeptidase activity
H5404_RS02715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_RS02725	COG2067	long-chain fatty acid transport protein
H5404_RS02735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5404_RS02765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_RS02785	COG3383	formate dehydrogenase (NAD+) activity
H5404_RS02800	COG0842	Transport permease protein
H5404_RS02805	COG1131	(ABC) transporter
H5404_RS02820	COG2706	6-phosphogluconolactonase activity
H5404_RS02830	COG1881	PFAM PEBP family protein
H5404_RS02840	COG0798	PFAM Bile acid sodium symporter
H5404_RS02855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_RS02860	COG2213	PTS system mannitol-specific
H5404_RS02865	COG1063	alcohol dehydrogenase
H5404_RS02875	COG1072	(Pantothenic acid kinase))
H5404_RS02880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H5404_RS03120	COG2842	Transposition protein
H5404_RS03155	COG0814	amino acid
H5404_RS03170	COG3314	Sporulation integral membrane protein YlbJ
H5404_RS03190	COG0739	heme binding
H5404_RS03200	COG0583	DNA-binding transcription factor activity
H5404_RS03205	COG2814	Major facilitator Superfamily
H5404_RS03220	COG0697	spore germination
H5404_RS03250	COG2207	Transcriptional regulator
H5404_RS03255	COG1280	lysine exporter protein (LysE YggA)
H5404_RS03265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5404_RS03270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5404_RS03280	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H5404_RS03305	COG1612	heme a metabolic process
H5404_RS03310	COG0109	protoheme IX farnesyltransferase activity
H5404_RS03315	COG0545	Peptidyl-prolyl cis-trans isomerase
H5404_RS03345	COG1278	Cold shock
H5404_RS03350	COG3036	rescue of stalled ribosome
H5404_RS03360	COG2199	diguanylate cyclase activity
H5404_RS03380	COG1136	(ABC) transporter
H5404_RS03380	COG0577	efflux transmembrane transporter activity
H5404_RS03390	COG0840	transmembrane signaling receptor activity
H5404_RS03395	COG0783	Belongs to the Dps family
H5404_RS03405	COG2133	pyrroloquinoline quinone binding
H5404_RS03410	COG1454	alcohol dehydrogenase
H5404_RS03415	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H5404_RS03455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5404_RS03460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5404_RS03465	COG3186	Phenylalanine-4-hydroxylase
H5404_RS03470	COG2154	pterin-4-alpha-carbinolamine dehydratase
H5404_RS03490	COG3530	Putative quorum-sensing-regulated virulence factor
H5404_RS03495	COG0513	Belongs to the DEAD box helicase family
H5404_RS03500	COG4628	conserved protein (DUF2132)
H5404_RS03505	COG0133	tryptophan synthase activity
H5404_RS03515	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H5404_RS03525	COG0523	cobalamin synthesis protein
H5404_RS03530	COG0513	Belongs to the DEAD box helicase family
H5404_RS03550	COG2200	EAL domain
H5404_RS03555	COG1119	ATPase activity
H5404_RS03560	COG0840	transmembrane signaling receptor activity
H5404_RS03580	COG0641	radical SAM
H5404_RS03600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H5404_RS03615	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H5404_RS03620	COG0513	Belongs to the DEAD box helicase family
H5404_RS03625	COG5001	Diguanylate cyclase
H5404_RS03630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H5404_RS03645	COG5413	integral membrane protein
H5404_RS03655	COG1024	Enoyl-CoA hydratase
H5404_RS03660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5404_RS03665	COG1960	acyl-CoA dehydrogenase activity
H5404_RS03675	COG0183	Belongs to the thiolase family
H5404_RS03690	COG1024	Enoyl-CoA hydratase
H5404_RS03695	COG1024	Enoyl-CoA hydratase
H5404_RS03705	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS03710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5404_RS03715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5404_RS03720	COG1845	cytochrome c oxidase, subunit III
H5404_RS03725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H5404_RS03730	COG0109	protoheme IX farnesyltransferase activity
H5404_RS03735	COG1902	pentaerythritol trinitrate reductase activity
H5404_RS03745	COG1126	abc transporter atp-binding protein
H5404_RS03750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_RS03755	COG4215	(ABC) transporter
H5404_RS03760	COG4160	amino acid transport
H5404_RS03775	COG0625	glutathione transferase activity
H5404_RS03810	COG0443	Heat shock 70 kDa protein
H5404_RS03815	COG2847	Copper chaperone PCu(A)C
H5404_RS03835	COG4607	ABC-type enterochelin transport system periplasmic component
H5404_RS03840	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5404_RS03845	COG4605	iron ion homeostasis
H5404_RS03850	COG4604	ABC transporter, ATP-binding protein
H5404_RS03855	COG0789	Transcriptional regulator
H5404_RS03860	COG2207	Transcriptional regulator
H5404_RS03865	COG1629	transport
H5404_RS03865	COG4771	TonB-dependent receptor
H5404_RS03895	COG1289	transmembrane transporter activity
H5404_RS03900	COG0210	DNA helicase
H5404_RS03905	COG1803	Methylglyoxal synthase
H5404_RS03910	COG1879	ABC-type sugar transport system periplasmic component
H5404_RS03915	COG2198	Histidine kinase
H5404_RS03915	COG0784	Response regulator, receiver
H5404_RS03915	COG2205	protein histidine kinase activity
H5404_RS03930	COG0745	RESPONSE REGULATOR receiver
H5404_RS03935	COG3119	arylsulfatase activity
H5404_RS03940	COG3119	arylsulfatase activity
H5404_RS03955	COG3119	arylsulfatase activity
H5404_RS03960	COG0641	radical SAM
H5404_RS03965	COG0714	Associated with various cellular activities
H5404_RS03995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5404_RS04000	COG0583	DNA-binding transcription factor activity
H5404_RS04005	COG1597	lipid kinase activity
H5404_RS04010	COG3111	PFAM Bacterial OB fold (BOF) protein
H5404_RS04025	COG0641	radical SAM
H5404_RS04050	COG0501	Belongs to the peptidase M48B family
H5404_RS04055	COG1704	LemA family
H5404_RS04060	COG3069	C4-dicarboxylate transmembrane transporter activity
H5404_RS04070	COG1214	PFAM Peptidase M22, glycoprotease
H5404_RS04070	COG0456	acetyltransferase
H5404_RS04090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H5404_RS04110	COG2207	Transcriptional regulator
H5404_RS04135	COG4964	Belongs to the GSP D family
H5404_RS04195	COG0583	DNA-binding transcription factor activity
H5404_RS04200	COG0583	DNA-binding transcription factor activity
H5404_RS04215	COG3300	MHYT domain
H5404_RS04215	COG5001	Diguanylate cyclase
H5404_RS04220	COG2197	response regulator
H5404_RS04225	COG3706	GGDEF domain
H5404_RS04235	COG2197	response regulator
H5404_RS04255	COG0835	chemotaxis
H5404_RS04255	COG0784	Response regulator, receiver
H5404_RS04270	COG2962	Rard protein
H5404_RS04280	COG0671	phosphoesterase, PA-phosphatase related
H5404_RS04295	COG2076	Multidrug Resistance protein
H5404_RS04325	COG0471	metal ion transport
H5404_RS04330	COG3290	protein histidine kinase activity
H5404_RS04335	COG4565	transcriptional regulatory protein
H5404_RS04350	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H5404_RS04355	COG5642	Protein of unknown function (DUF2384)
H5404_RS04375	COG1902	pentaerythritol trinitrate reductase activity
H5404_RS04380	COG0346	lactoylglutathione lyase activity
H5404_RS04400	COG2239	Acts as a magnesium transporter
H5404_RS04420	COG0242	peptide deformylase activity
H5404_RS04465	COG2176	DNA-directed DNA polymerase activity
H5404_RS04470	COG0583	DNA-binding transcription factor activity
H5404_RS04475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H5404_RS04510	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5404_RS04515	COG3344	reverse transcriptase
H5404_RS04525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5404_RS04555	COG0602	queuosine metabolic process
H5404_RS04560	COG0534	Mate efflux family protein
H5404_RS04575	COG0189	ligase activity
H5404_RS04575	COG4067	protein conserved in archaea
H5404_RS04585	COG3111	PFAM Bacterial OB fold (BOF) protein
H5404_RS04590	COG1492	cobalamin metabolic process
H5404_RS04595	COG0725	ABC transporter, periplasmic molybdate-binding protein
H5404_RS04600	COG4149	molybdate abc transporter
H5404_RS04605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H5404_RS04615	COG5001	Diguanylate cyclase
H5404_RS04615	COG3706	GGDEF domain
H5404_RS04615	COG4251	negative regulation of phosphorylation
H5404_RS04615	COG2203	Gaf domain
H5404_RS04640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H5404_RS04645	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H5404_RS04670	COG3140	Belongs to the UPF0181 family
H5404_RS04675	COG0589	response to stress
H5404_RS04685	COG0583	DNA-binding transcription factor activity
H5404_RS04700	COG0023	Translation Initiation Factor
H5404_RS04710	COG1181	Belongs to the D-alanine--D-alanine ligase family
H5404_RS04720	COG0045	succinate-CoA ligase (ADP-forming) activity
H5404_RS04720	COG1042	CoA-binding domain protein
H5404_RS04720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5404_RS04725	COG0583	DNA-binding transcription factor activity
H5404_RS04730	COG4771	TonB-dependent receptor
H5404_RS04730	COG1629	transport
H5404_RS04735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5404_RS04740	COG3447	MASE1 domain protein
H5404_RS04740	COG5001	Diguanylate cyclase
H5404_RS04740	COG5002	protein histidine kinase activity
H5404_RS04745	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H5404_RS04750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H5404_RS04755	COG1984	allophanate hydrolase subunit 2
H5404_RS04765	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H5404_RS04770	COG4181	ATPase activity
H5404_RS04780	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5404_RS04785	COG3300	MHYT domain
H5404_RS04785	COG5001	Diguanylate cyclase
H5404_RS04795	COG0484	heat shock protein binding
H5404_RS04820	COG4533	DNA binding
H5404_RS04830	COG2050	protein possibly involved in aromatic compounds catabolism
H5404_RS04845	COG2067	long-chain fatty acid transport protein
H5404_RS04850	COG2267	carboxylic ester hydrolase activity
H5404_RS04865	COG0861	Integral membrane protein TerC family
H5404_RS04870	COG0737	Belongs to the 5'-nucleotidase family
H5404_RS04875	COG3593	DNA synthesis involved in DNA repair
H5404_RS04885	COG0583	DNA-binding transcription factor activity
H5404_RS04890	COG2116	formate transmembrane transporter activity
H5404_RS04895	COG2353	YceI-like domain
H5404_RS04900	COG3038	cytochrome b561
H5404_RS04915	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H5404_RS04920	COG0513	Belongs to the DEAD box helicase family
H5404_RS04925	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H5404_RS04930	COG0840	transmembrane signaling receptor activity
H5404_RS04935	COG0546	phosphoglycolate phosphatase activity
H5404_RS04940	COG3437	response regulator, receiver
H5404_RS04940	COG0784	Response regulator, receiver
H5404_RS04955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5404_RS04960	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H5404_RS04965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H5404_RS04975	COG2207	Transcriptional regulator
H5404_RS04980	COG1979	alcohol dehydrogenase
H5404_RS05005	COG2271	Major facilitator Superfamily
H5404_RS05010	COG0469	pyruvate kinase activity
H5404_RS05015	COG1126	abc transporter atp-binding protein
H5404_RS05020	COG0765	amino acid transport
H5404_RS05025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_RS05030	COG0765	amino acid transport
H5404_RS05035	COG2203	Gaf domain
H5404_RS05035	COG2199	diguanylate cyclase activity
H5404_RS05035	COG2200	EAL domain
H5404_RS05050	COG1609	Transcriptional regulator
H5404_RS05055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_RS05055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_RS05060	COG1105	Belongs to the carbohydrate kinase PfkB family
H5404_RS05065	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H5404_RS05065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_RS05065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_RS05085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_RS05105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5404_RS05110	COG0509	glycine decarboxylation via glycine cleavage system
H5404_RS05115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5404_RS05115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5404_RS05120	COG3344	reverse transcriptase
H5404_RS05145	COG3550	peptidyl-serine autophosphorylation
H5404_RS05210	COG1328	CTP reductase activity
H5404_RS05225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_RS05255	COG0243	molybdopterin cofactor binding
H5404_RS05260	COG0583	DNA-binding transcription factor activity
H5404_RS05265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5404_RS05275	COG2197	response regulator
H5404_RS05280	COG3851	Histidine kinase
H5404_RS05285	COG2271	Major facilitator Superfamily
H5404_RS05310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5404_RS05315	COG3118	belongs to the thioredoxin family
H5404_RS05325	COG0745	RESPONSE REGULATOR receiver
H5404_RS05325	COG2205	protein histidine kinase activity
H5404_RS05325	COG3292	Two component regulator propeller
H5404_RS05330	COG0534	Mate efflux family protein
H5404_RS05360	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H5404_RS05380	COG2116	formate transmembrane transporter activity
H5404_RS05390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5404_RS05395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5404_RS05430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5404_RS05430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5404_RS05470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5404_RS05485	COG0277	FAD linked oxidase domain protein
H5404_RS05490	COG0583	DNA-binding transcription factor activity
H5404_RS05505	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H5404_RS05520	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H5404_RS05530	COG1288	antiporter activity
H5404_RS05540	COG2814	Major facilitator Superfamily
H5404_RS05550	COG3040	lipid binding
H5404_RS05570	COG0419	ATPase involved in DNA repair
H5404_RS05575	COG0420	3'-5' exonuclease activity
H5404_RS05645	COG0631	protein serine/threonine phosphatase activity
H5404_RS05680	COG0515	serine threonine protein kinase
H5404_RS05680	COG2815	serine threonine protein kinase
H5404_RS05735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5404_RS05735	COG2146	nitrite reductase [NAD(P)H] activity
H5404_RS05740	COG1116	anion transmembrane transporter activity
H5404_RS05745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5404_RS05750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5404_RS05755	COG3707	response regulator
H5404_RS05770	COG1648	precorrin-2 dehydrogenase activity
H5404_RS05770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5404_RS05775	COG0243	molybdopterin cofactor binding
H5404_RS05785	COG0814	amino acid
H5404_RS05810	COG1785	Belongs to the alkaline phosphatase family
H5404_RS05825	COG0745	RESPONSE REGULATOR receiver
H5404_RS05845	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H5404_RS05860	COG1609	Transcriptional regulator
H5404_RS05865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5404_RS05870	COG1879	ABC-type sugar transport system periplasmic component
H5404_RS05875	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5404_RS05880	COG1129	ABC transporter
H5404_RS05885	COG1869	D-ribose catabolic process
H5404_RS05890	COG5001	Diguanylate cyclase
H5404_RS05895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5404_RS05950	COG0784	Response regulator, receiver
H5404_RS05950	COG2205	protein histidine kinase activity
H5404_RS05960	COG5001	Diguanylate cyclase
H5404_RS05960	COG3300	MHYT domain
H5404_RS05970	COG0330	HflC and HflK could
H5404_RS05985	COG4175	Glycine betaine
H5404_RS05985	COG0517	IMP dehydrogenase activity
H5404_RS05990	COG4176	ABC-type proline glycine betaine transport system permease component
H5404_RS06005	COG1012	belongs to the aldehyde dehydrogenase family
H5404_RS06010	COG1309	transcriptional regulator
H5404_RS06015	COG3706	GGDEF domain
H5404_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS06035	COG1024	Enoyl-CoA hydratase
H5404_RS06040	COG1960	acyl-CoA dehydrogenase activity
H5404_RS06050	COG0183	Belongs to the thiolase family
H5404_RS06060	COG1960	acyl-CoA dehydrogenase activity
H5404_RS06065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5404_RS06070	COG1024	Enoyl-CoA hydratase
H5404_RS06085	COG3437	response regulator, receiver
H5404_RS06085	COG4999	Histidine kinase
H5404_RS06085	COG3850	Histidine kinase
H5404_RS06085	COG2205	protein histidine kinase activity
H5404_RS06100	COG3264	Mechanosensitive ion channel
H5404_RS06100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H5404_RS06105	COG0110	maltose O-acetyltransferase activity
H5404_RS06110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5404_RS06115	COG1271	oxidase subunit
H5404_RS06120	COG1294	oxidase, subunit
H5404_RS06130	COG0384	phenazine biosynthesis protein PhzF
H5404_RS06135	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5404_RS06140	COG0789	Transcriptional regulator
H5404_RS06150	COG3474	cytochrome
H5404_RS06215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5404_RS06220	COG0516	GMP reductase activity
H5404_RS06225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5404_RS06225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5404_RS06240	COG4989	oxidoreductase activity
H5404_RS06255	COG0038	chloride channel
H5404_RS06265	COG1914	H( )-stimulated, divalent metal cation uptake system
H5404_RS06270	COG0302	gtp cyclohydrolase
H5404_RS06280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5404_RS06300	COG2897	thiosulfate sulfurtransferase activity
H5404_RS06320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5404_RS06325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5404_RS06330	COG0840	transmembrane signaling receptor activity
H5404_RS06335	COG2814	Major facilitator Superfamily
H5404_RS06340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5404_RS06350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5404_RS06360	COG0840	transmembrane signaling receptor activity
H5404_RS06380	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5404_RS06395	COG2197	response regulator
H5404_RS06400	COG3850	Histidine kinase
H5404_RS06405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5404_RS06415	COG0243	molybdopterin cofactor binding
H5404_RS06425	COG3005	denitrification pathway
H5404_RS06435	COG3243	poly(R)-hydroxyalkanoic acid synthase
H5404_RS06445	COG0183	Belongs to the thiolase family
H5404_RS06455	COG1280	lysine exporter protein (LysE YggA)
H5404_RS06465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5404_RS06470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5404_RS06495	COG1522	sequence-specific DNA binding
H5404_RS06515	COG1566	PFAM secretion protein HlyD family protein
H5404_RS06530	COG1879	ABC-type sugar transport system periplasmic component
H5404_RS06535	COG2827	Endonuclease containing a URI domain
H5404_RS06540	COG3132	Protein of unknown function, DUF480
H5404_RS06550	COG2926	Belongs to the UPF0265 family
H5404_RS06555	COG0534	Mate efflux family protein
H5404_RS06560	COG0673	inositol 2-dehydrogenase activity
H5404_RS06565	COG2205	protein histidine kinase activity
H5404_RS06565	COG0784	Response regulator, receiver
H5404_RS06565	COG5002	protein histidine kinase activity
H5404_RS06590	COG1522	sequence-specific DNA binding
H5404_RS06595	COG0531	amino acid
H5404_RS06610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5404_RS06615	COG2239	Acts as a magnesium transporter
H5404_RS06620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H5404_RS06625	COG0402	S-adenosylhomocysteine deaminase activity
H5404_RS06635	COG1418	mRNA catabolic process
H5404_RS06645	COG2814	Major facilitator Superfamily
H5404_RS06655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5404_RS06675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5404_RS06690	COG4221	oxidoreductase activity
H5404_RS06695	COG0745	RESPONSE REGULATOR receiver
H5404_RS06700	COG2205	protein histidine kinase activity
H5404_RS06710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H5404_RS06715	COG2194	sulfuric ester hydrolase activity
H5404_RS06720	COG0673	inositol 2-dehydrogenase activity
H5404_RS06730	COG2814	Major facilitator Superfamily
H5404_RS06755	COG4667	esterase of the alpha-beta hydrolase superfamily
H5404_RS06760	COG1741	Belongs to the pirin family
H5404_RS06765	COG1278	Cold shock
H5404_RS06780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H5404_RS06795	COG1686	Belongs to the peptidase S11 family
H5404_RS06800	COG0625	glutathione transferase activity
H5404_RS06810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H5404_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS06845	COG3746	phosphate-selective porin O and P
H5404_RS06865	COG3833	ABC-type maltose transport systems, permease component
H5404_RS06870	COG1175	transmembrane transport
H5404_RS06880	COG3842	ATPase activity
H5404_RS06885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5404_RS06910	COG0438	transferase activity, transferring glycosyl groups
H5404_RS06940	COG3097	Belongs to the UPF0267 family
H5404_RS06945	COG1309	transcriptional regulator
H5404_RS06950	COG2130	NADP-dependent
H5404_RS06960	COG0753	catalase activity
H5404_RS06965	COG2084	Dehydrogenase
H5404_RS06970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_RS06975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_RS06985	COG2207	Transcriptional regulator
H5404_RS06990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_RS06990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_RS06990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_RS07005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5404_RS07010	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H5404_RS07020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5404_RS07025	COG0569	domain protein
H5404_RS07035	COG2205	protein histidine kinase activity
H5404_RS07035	COG2205	protein histidine kinase activity
H5404_RS07040	COG1132	(ABC) transporter
H5404_RS07045	COG4774	siderophore transport
H5404_RS07050	COG1120	ATPase activity
H5404_RS07055	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H5404_RS07115	COG0840	transmembrane signaling receptor activity
H5404_RS07120	COG0714	Associated with various cellular activities
H5404_RS07140	COG2304	oxidoreductase activity
H5404_RS07155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5404_RS07160	COG0581	inorganic phosphate transmembrane transporter activity
H5404_RS07165	COG0573	inorganic phosphate transmembrane transporter activity
H5404_RS07195	COG4771	TonB-dependent receptor
H5404_RS07200	COG1770	oligopeptidase
H5404_RS07205	COG0513	Belongs to the DEAD box helicase family
H5404_RS07215	COG1388	LysM domain
H5404_RS07215	COG1376	ErfK ybiS ycfS ynhG family protein
H5404_RS07220	COG0415	Belongs to the DNA photolyase family
H5404_RS07225	COG0789	Transcriptional regulator
H5404_RS07230	COG3272	Protein of unknown function (DUF1722)
H5404_RS07235	COG0813	purine-nucleoside phosphorylase activity
H5404_RS07250	COG3706	GGDEF domain
H5404_RS07260	COG1566	PFAM secretion protein HlyD family protein
H5404_RS07265	COG4720	Psort location CytoplasmicMembrane, score
H5404_RS07270	COG1122	ATPase activity
H5404_RS07285	COG0348	domain, Protein
H5404_RS07290	COG0437	4 iron, 4 sulfur cluster binding
H5404_RS07295	COG1247	-acetyltransferase
H5404_RS07320	COG1067	ATP-dependent peptidase activity
H5404_RS07330	COG4172	Belongs to the ABC transporter superfamily
H5404_RS07335	COG1505	serine-type exopeptidase activity
H5404_RS07340	COG0583	DNA-binding transcription factor activity
H5404_RS07345	COG1620	l-lactate permease
H5404_RS07350	COG1304	FMN binding
H5404_RS07360	COG0668	transmembrane transport
H5404_RS07395	COG0582	viral genome integration into host DNA
H5404_RS07415	COG1063	alcohol dehydrogenase
H5404_RS07420	COG0156	8-amino-7-oxononanoate synthase activity
H5404_RS07430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_RS07450	COG0745	RESPONSE REGULATOR receiver
H5404_RS07475	COG0346	lactoylglutathione lyase activity
H5404_RS07495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H5404_RS07575	COG1987	bacterial-type flagellum assembly
H5404_RS07585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5404_RS07600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_RS07610	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H5404_RS07615	COG1516	flagellar protein fliS
H5404_RS07630	COG1580	Controls the rotational direction of flagella during chemotaxis
H5404_RS07635	COG1191	sigma factor activity
H5404_RS07640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5404_RS07645	COG1360	Flagellar Motor Protein
H5404_RS07675	COG1882	Formate acetyltransferase
H5404_RS07680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H5404_RS07685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5404_RS07695	COG0454	-acetyltransferase
H5404_RS07705	COG2814	Major facilitator Superfamily
H5404_RS07745	COG0628	permease
H5404_RS07750	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H5404_RS07760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5404_RS07770	COG4628	conserved protein (DUF2132)
H5404_RS07775	COG0583	DNA-binding transcription factor activity
H5404_RS07800	COG1686	Belongs to the peptidase S11 family
H5404_RS07815	COG1054	Belongs to the UPF0176 family
H5404_RS07820	COG3397	chitin binding
H5404_RS07825	COG4667	esterase of the alpha-beta hydrolase superfamily
H5404_RS07830	COG2095	MarC family integral membrane protein
H5404_RS07850	COG3206	protein involved in exopolysaccharide biosynthesis
H5404_RS07850	COG0489	protein tyrosine kinase activity
H5404_RS07865	COG0583	DNA-binding transcription factor activity
H5404_RS07875	COG1301	dicarboxylic acid transport
H5404_RS07880	COG3339	Conserved Protein
H5404_RS07885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5404_RS07890	COG0700	Nucleoside recognition
H5404_RS07895	COG3366	ferrous iron transmembrane transporter activity
H5404_RS07910	COG0366	Alpha amylase catalytic
H5404_RS07915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5404_RS07920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H5404_RS07925	COG1640	4-alpha-glucanotransferase
H5404_RS07930	COG0058	SHG alpha-glucan phosphorylase activity
H5404_RS07935	COG2909	trisaccharide binding
H5404_RS07950	COG1999	signal sequence binding
H5404_RS07960	COG1263	PTS System
H5404_RS07960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5404_RS07965	COG1162	GTPase activity
H5404_RS07970	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H5404_RS07980	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H5404_RS07990	COG0531	amino acid
H5404_RS07995	COG1982	Orn Lys Arg decarboxylase major
H5404_RS08015	COG2356	endonuclease I
H5404_RS08035	COG4580	involved in the transport of maltose and maltodextrins
H5404_RS08050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H5404_RS08055	COG0592	DNA-directed DNA polymerase activity
H5404_RS08060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5404_RS08065	COG0187	DNA topoisomerase II activity
H5404_RS08075	COG0071	Belongs to the small heat shock protein (HSP20) family
H5404_RS08080	COG3977	Valine--pyruvate aminotransferase
H5404_RS08085	COG0366	Alpha amylase catalytic
H5404_RS08090	COG0751	glycine-tRNA ligase activity
H5404_RS08095	COG0752	glycyl-tRNA synthetase alpha subunit
H5404_RS08100	COG2119	membrane
H5404_RS08110	COG0425	Belongs to the sulfur carrier protein TusA family
H5404_RS08125	COG0604	alcohol dehydrogenase
H5404_RS08130	COG0183	Belongs to the thiolase family
H5404_RS08135	COG1024	Enoyl-CoA hydratase
H5404_RS08135	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5404_RS08140	COG1739	Uncharacterized protein family UPF0029
H5404_RS08145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5404_RS08185	COG0583	DNA-binding transcription factor activity
H5404_RS08190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H5404_RS08195	COG2960	long-chain fatty acid transporting porin activity
H5404_RS08200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_RS08205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_RS08255	COG4172	Belongs to the ABC transporter superfamily
H5404_RS08260	COG0747	negative chemotaxis
H5404_RS08265	COG0601	transmembrane transport
H5404_RS08270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5404_RS08305	COG1609	Transcriptional regulator
H5404_RS08310	COG0583	DNA-binding transcription factor activity
H5404_RS08325	COG0129	dihydroxy-acid dehydratase activity
H5404_RS08330	COG3265	gluconokinase activity
H5404_RS08335	COG2610	gluconate transmembrane transporter activity
H5404_RS08340	COG0800	Aldolase
H5404_RS08345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H5404_RS08350	COG0583	DNA-binding transcription factor activity
H5404_RS08355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5404_RS08360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H5404_RS08365	COG0339	signal peptide processing
H5404_RS08370	COG1522	sequence-specific DNA binding
H5404_RS08375	COG5001	Diguanylate cyclase
H5404_RS08375	COG5002	protein histidine kinase activity
H5404_RS08380	COG0742	ribosomal rna small subunit methyltransferase
H5404_RS08395	COG0589	response to stress
H5404_RS08400	COG1528	Iron-storage protein
H5404_RS08410	COG2081	HI0933 family
H5404_RS08420	COG2823	Periplasmic or secreted lipoprotein
H5404_RS08470	COG0628	permease
H5404_RS08485	COG1322	Protein conserved in bacteria
H5404_RS08490	COG2226	methyltransferase
H5404_RS08500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5404_RS08505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5404_RS08510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5404_RS08515	COG0805	protein transport
H5404_RS08520	COG0084	hydrolase, TatD family'
H5404_RS08535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5404_RS08535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5404_RS08540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H5404_RS08570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H5404_RS08580	COG2204	response regulator
H5404_RS08585	COG3852	Histidine kinase
H5404_RS08595	COG0174	glutamine synthetase
H5404_RS08600	COG1217	gtp-binding protein TYPA
H5404_RS08615	COG1295	ribonuclease BN
H5404_RS08620	COG1490	D-aminoacyl-tRNA deacylase activity
H5404_RS08625	COG0456	acetyltransferase
H5404_RS08635	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H5404_RS08640	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H5404_RS08645	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H5404_RS08650	COG3031	protein transport across the cell outer membrane
H5404_RS08660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5404_RS08665	COG1459	type II secretion system
H5404_RS08670	COG2165	general secretion pathway protein
H5404_RS08675	COG2165	general secretion pathway protein
H5404_RS08680	COG2165	general secretion pathway protein
H5404_RS08685	COG4795	General secretion pathway protein
H5404_RS08690	COG3156	type II secretion system protein K
H5404_RS08695	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H5404_RS08700	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H5404_RS08710	COG1218	3'(2'),5'-bisphosphate nucleotidase
H5404_RS08715	COG0494	nUDIX hydrolase
H5404_RS08720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H5404_RS08720	COG0316	Belongs to the HesB IscA family
H5404_RS08725	COG1040	competence protein
H5404_RS08730	COG0596	Alpha beta hydrolase
H5404_RS08740	COG2183	response to ionizing radiation
H5404_RS08750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5404_RS08770	COG2233	PERMEase
H5404_RS08775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H5404_RS08780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5404_RS08785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5404_RS08790	COG1758	RNA polymerase activity
H5404_RS08795	COG0194	GDP metabolic process
H5404_RS08810	COG0848	biopolymer transport protein
H5404_RS08815	COG0811	peptide transport
H5404_RS08835	COG4174	ABC transporter (Permease)
H5404_RS08840	COG4239	(ABC) transporter, permease
H5404_RS08845	COG0747	negative chemotaxis
H5404_RS08850	COG0444	Belongs to the ABC transporter superfamily
H5404_RS08855	COG4608	Belongs to the ABC transporter superfamily
H5404_RS08865	COG1561	YicC-like family, N-terminal region
H5404_RS08870	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H5404_RS08875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H5404_RS08880	COG1560	Kdo2-lipid A biosynthetic process
H5404_RS08885	COG1309	transcriptional regulator
H5404_RS08890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H5404_RS08895	COG0840	transmembrane signaling receptor activity
H5404_RS08900	COG2003	Belongs to the UPF0758 family
H5404_RS08905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H5404_RS08920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H5404_RS08925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H5404_RS08940	COG0463	Glycosyl transferase, family 2
H5404_RS08945	COG0859	PFAM glycosyl transferase family 9
H5404_RS08950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H5404_RS08955	COG3642	lipopolysaccharide core region biosynthetic process
H5404_RS08985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5404_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS09000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5404_RS09025	COG1519	Transferase
H5404_RS09030	COG0859	PFAM glycosyl transferase family 9
H5404_RS09035	COG1560	Kdo2-lipid A biosynthetic process
H5404_RS09045	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5404_RS09080	COG0438	transferase activity, transferring glycosyl groups
H5404_RS09105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H5404_RS09105	COG2755	lipolytic protein G-D-S-L family
H5404_RS09115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5404_RS09135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H5404_RS09140	COG0149	triose-phosphate isomerase activity
H5404_RS09165	COG1494	fructose-1,6-bisphosphatase
H5404_RS09170	COG3074	FtsZ-dependent cytokinesis
H5404_RS09175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5404_RS09180	COG1575	Belongs to the MenA family. Type 1 subfamily
H5404_RS09185	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H5404_RS09190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H5404_RS09200	COG1609	Transcriptional regulator
H5404_RS09205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5404_RS09210	COG0254	rRNA binding
H5404_RS09220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H5404_RS09225	COG0088	Forms part of the polypeptide exit tunnel
H5404_RS09235	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H5404_RS09240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H5404_RS09245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H5404_RS09250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H5404_RS09260	COG0255	Belongs to the universal ribosomal protein uL29 family
H5404_RS09265	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H5404_RS09270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H5404_RS09275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H5404_RS09280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H5404_RS09285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H5404_RS09290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H5404_RS09295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H5404_RS09310	COG1841	ribosomal large subunit assembly
H5404_RS09315	COG0200	Binds to the 23S rRNA
H5404_RS09320	COG0201	protein transport
H5404_RS09325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H5404_RS09330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H5404_RS09335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H5404_RS09345	COG0202	RNA polymerase activity
H5404_RS09350	COG0203	ribosomal protein L17
H5404_RS09360	COG0545	Peptidyl-prolyl cis-trans isomerase
H5404_RS09370	COG2153	protein acetylation
H5404_RS09375	COG0513	Belongs to the DEAD box helicase family
H5404_RS09385	COG0737	Belongs to the 5'-nucleotidase family
H5404_RS09390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5404_RS09390	COG1648	precorrin-2 dehydrogenase activity
H5404_RS09395	COG0175	sulfate reduction
H5404_RS09400	COG2895	sulfate adenylyltransferase (ATP) activity
H5404_RS09405	COG3273	potassium ion transport
H5404_RS09405	COG0471	metal ion transport
H5404_RS09410	COG0529	Catalyzes the synthesis of activated sulfate
H5404_RS09430	COG4181	ATPase activity
H5404_RS09445	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H5404_RS09455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5404_RS09460	COG0729	surface antigen
H5404_RS09470	COG2105	PFAM AIG2 family protein
H5404_RS09480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5404_RS09485	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H5404_RS09490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5404_RS09495	COG0163	prenyltransferase activity
H5404_RS09500	COG4143	(ABC) transporter
H5404_RS09505	COG1178	ABC-type Fe3 transport system permease component
H5404_RS09510	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H5404_RS09525	COG2358	TRAP transporter, solute receptor (TAXI family
H5404_RS09535	COG0039	L-malate dehydrogenase activity
H5404_RS09545	COG0142	geranyltranstransferase activity
H5404_RS09550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H5404_RS09560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H5404_RS09565	COG2966	Psort location CytoplasmicMembrane, score
H5404_RS09580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5404_RS09585	COG2967	ApaG domain
H5404_RS09590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5404_RS09595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H5404_RS09600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5404_RS09605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H5404_RS09610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5404_RS09620	COG0066	3-isopropylmalate dehydratase activity
H5404_RS09625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H5404_RS09630	COG0473	3-isopropylmalate dehydrogenase activity
H5404_RS09635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5404_RS09655	COG0583	DNA-binding transcription factor activity
H5404_RS09660	COG1022	Amp-dependent synthetase and ligase
H5404_RS09665	COG0028	Belongs to the TPP enzyme family
H5404_RS09670	COG0440	acetolactate synthase activity
H5404_RS09685	COG0469	pyruvate kinase activity
H5404_RS09690	COG1349	DNA-binding transcription factor activity
H5404_RS09695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5404_RS09710	COG5002	protein histidine kinase activity
H5404_RS09720	COG2376	Dihydroxyacetone kinase
H5404_RS09725	COG1461	Dihydroxyacetone kinase
H5404_RS09740	COG3722	fumarate hydratase activity
H5404_RS09745	COG0246	Mannitol dehydrogenase
H5404_RS09750	COG2213	PTS system mannitol-specific
H5404_RS09750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_RS09780	COG1464	Belongs to the NlpA lipoprotein family
H5404_RS09815	COG0789	Transcriptional regulator
H5404_RS09880	COG3328	transposase activity
H5404_RS09890	COG1566	PFAM secretion protein HlyD family protein
H5404_RS09925	COG0358	DNA primase activity
H5404_RS09930	COG1610	YqeY-like protein
H5404_RS09935	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H5404_RS09940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H5404_RS09945	COG0596	Alpha beta hydrolase
H5404_RS09950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H5404_RS09955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H5404_RS09960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5404_RS09965	COG1968	undecaprenyl-diphosphatase activity
H5404_RS09970	COG0617	tRNA 3'-terminal CCA addition
H5404_RS09975	COG3409	Peptidoglycan-binding domain 1 protein
H5404_RS09975	COG3267	Type II secretory pathway component ExeA
H5404_RS09985	COG4991	sh3 domain protein
H5404_RS09990	COG0306	phosphate transporter
H5404_RS09995	COG1392	Phosphate transport regulator
H5404_RS10000	COG3025	triphosphatase activity
H5404_RS10015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H5404_RS10020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H5404_RS10020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H5404_RS10025	COG1538	Outer membrane efflux protein
H5404_RS10030	COG0494	nUDIX hydrolase
H5404_RS10035	COG3151	Protein conserved in bacteria
H5404_RS10045	COG3150	esterase
H5404_RS10060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5404_RS10070	COG3105	Protein conserved in bacteria
H5404_RS10075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H5404_RS10080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H5404_RS10085	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5404_RS10090	COG0723	plastoquinol--plastocyanin reductase activity
H5404_RS10095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H5404_RS10100	COG2857	Cytochrome c1
H5404_RS10105	COG0625	glutathione transferase activity
H5404_RS10110	COG2969	positive regulation of protein catabolic process
H5404_RS10115	COG2823	Periplasmic or secreted lipoprotein
H5404_RS10120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H5404_RS10125	COG0792	nuclease activity
H5404_RS10135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H5404_RS10145	COG0275	rRNA processing
H5404_RS10150	COG3116	cell division
H5404_RS10155	COG0768	penicillin binding
H5404_RS10160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5404_RS10165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H5404_RS10170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5404_RS10175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H5404_RS10180	COG0772	Belongs to the SEDS family
H5404_RS10185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H5404_RS10190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5404_RS10195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5404_RS10200	COG0849	cell division
H5404_RS10205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5404_RS10210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H5404_RS10220	COG0653	protein targeting
H5404_RS10225	COG0494	nUDIX hydrolase
H5404_RS10230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H5404_RS10235	COG0505	Belongs to the CarA family
H5404_RS10240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H5404_RS10255	COG0730	response to heat
H5404_RS10260	COG0583	DNA-binding transcription factor activity
H5404_RS10265	COG2860	membrane
H5404_RS10270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5404_RS10280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5404_RS10290	COG0493	'glutamate synthase
H5404_RS10295	COG0070	glutamate synthase
H5404_RS10295	COG0067	glutamate synthase
H5404_RS10295	COG0069	glutamate synthase activity
H5404_RS10305	COG0069	glutamate synthase activity
H5404_RS10305	COG0070	glutamate synthase
H5404_RS10305	COG0067	glutamate synthase
H5404_RS10310	COG1242	4 iron, 4 sulfur cluster binding
H5404_RS10315	COG4251	negative regulation of phosphorylation
H5404_RS10315	COG2203	Gaf domain
H5404_RS10315	COG3706	GGDEF domain
H5404_RS10315	COG5001	Diguanylate cyclase
H5404_RS10320	COG5002	protein histidine kinase activity
H5404_RS10320	COG2198	Histidine kinase
H5404_RS10320	COG0784	Response regulator, receiver
H5404_RS10330	COG0745	RESPONSE REGULATOR receiver
H5404_RS10340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5404_RS10355	COG0083	homoserine kinase activity
H5404_RS10360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H5404_RS10365	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H5404_RS10370	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H5404_RS10375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H5404_RS10390	COG1115	amino acid carrier protein
H5404_RS10395	COG3022	response to hydroperoxide
H5404_RS10400	COG0513	Belongs to the DEAD box helicase family
H5404_RS10405	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H5404_RS10415	COG0716	FMN binding
H5404_RS10420	COG4974	Belongs to the 'phage' integrase family
H5404_RS10425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5404_RS10430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5404_RS10440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H5404_RS10455	COG0667	Aldo Keto reductase
H5404_RS10465	COG3066	DNA modification
H5404_RS10470	COG0494	nUDIX hydrolase
H5404_RS10480	COG0730	response to heat
H5404_RS10485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H5404_RS10495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H5404_RS10520	COG3550	peptidyl-serine autophosphorylation
H5404_RS10545	COG1566	PFAM secretion protein HlyD family protein
H5404_RS10555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5404_RS10575	COG4974	Belongs to the 'phage' integrase family
H5404_RS10590	COG1283	sodium-dependent phosphate transmembrane transporter activity
H5404_RS10595	COG0583	DNA-binding transcription factor activity
H5404_RS10600	COG0640	Transcriptional regulator
H5404_RS10605	COG0268	Binds directly to 16S ribosomal RNA
H5404_RS10610	COG0728	peptidoglycan biosynthetic process
H5404_RS10615	COG0196	riboflavin kinase activity
H5404_RS10620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5404_RS10625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H5404_RS10630	COG1047	Peptidyl-prolyl cis-trans
H5404_RS10635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H5404_RS10640	COG3279	Response regulator of the LytR AlgR family
H5404_RS10645	COG3275	phosphorelay sensor kinase activity
H5404_RS10650	COG1966	Carbon starvation protein
H5404_RS10665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H5404_RS10670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H5404_RS10675	COG1472	Belongs to the glycosyl hydrolase 3 family
H5404_RS10680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5404_RS10685	COG1605	Chorismate mutase
H5404_RS10685	COG0287	Prephenate dehydrogenase
H5404_RS10690	COG0739	heme binding
H5404_RS10700	COG0488	(ABC) transporter
H5404_RS10710	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H5404_RS10715	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H5404_RS10720	COG1605	Chorismate mutase
H5404_RS10720	COG0077	Prephenate dehydratase
H5404_RS10725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H5404_RS10730	COG0741	lytic transglycosylase activity
H5404_RS10735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5404_RS10740	COG0564	pseudouridine synthase activity
H5404_RS10750	COG0542	response to heat
H5404_RS10805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5404_RS10810	COG0826	peptidase U32
H5404_RS10815	COG2974	May be involved in recombination
H5404_RS10820	COG0745	RESPONSE REGULATOR receiver
H5404_RS10825	COG5002	protein histidine kinase activity
H5404_RS10835	COG0248	Ppx GppA phosphatase
H5404_RS10840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H5404_RS10850	COG0581	inorganic phosphate transmembrane transporter activity
H5404_RS10855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5404_RS10860	COG0704	Plays a role in the regulation of phosphate uptake
H5404_RS10870	COG3142	Participates in the control of copper homeostasis
H5404_RS10875	COG0450	alkyl hydroperoxide reductase
H5404_RS10880	COG0583	DNA-binding transcription factor activity
H5404_RS10885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5404_RS10895	COG0517	IMP dehydrogenase activity
H5404_RS10905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H5404_RS10910	COG0343	queuine tRNA-ribosyltransferase activity
H5404_RS10915	COG1862	Preprotein translocase
H5404_RS10920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5404_RS10925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5404_RS10930	COG0483	inositol monophosphate 1-phosphatase activity
H5404_RS10945	COG1104	cysteine desulfurase activity
H5404_RS10950	COG0822	iron-sulfur transferase activity
H5404_RS10960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5404_RS10965	COG0443	Heat shock 70 kDa protein
H5404_RS10970	COG0633	Ferredoxin
H5404_RS10975	COG2975	iron-sulfur cluster assembly
H5404_RS10980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5404_RS10985	COG0105	UTP biosynthetic process
H5404_RS10990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H5404_RS11000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H5404_RS11005	COG0124	histidyl-tRNA synthetase
H5404_RS11010	COG2976	Protein conserved in bacteria
H5404_RS11015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5404_RS11020	COG1160	GTP binding
H5404_RS11035	COG1570	exodeoxyribonuclease VII activity
H5404_RS11040	COG0516	GMP reductase activity
H5404_RS11040	COG0517	IMP dehydrogenase activity
H5404_RS11045	COG0519	Catalyzes the synthesis of GMP from XMP
H5404_RS11045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5404_RS11050	COG1757	Na H antiporter
H5404_RS11060	COG1584	GPR1 FUN34 yaaH family protein
H5404_RS11070	COG1115	amino acid carrier protein
H5404_RS11100	COG2873	o-acetylhomoserine
H5404_RS11105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5404_RS11125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5404_RS11125	COG3153	acetyltransferase
H5404_RS11130	COG0583	DNA-binding transcription factor activity
H5404_RS11170	COG0270	DNA (cytosine-5-)-methyltransferase activity
H5404_RS11255	COG1278	Cold shock
H5404_RS11275	COG1278	Cold shock
H5404_RS11280	COG1196	nuclear chromosome segregation
H5404_RS11310	COG0270	DNA (cytosine-5-)-methyltransferase activity
H5404_RS11325	COG0582	viral genome integration into host DNA
H5404_RS11335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H5404_RS11340	COG2867	negative regulation of translational initiation
H5404_RS11345	COG2914	Belongs to the UPF0125 (RnfH) family
H5404_RS11350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5404_RS11355	COG0497	DNA recombination
H5404_RS11365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5404_RS11370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H5404_RS11380	COG0443	Heat shock 70 kDa protein
H5404_RS11385	COG0484	heat shock protein binding
H5404_RS11415	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H5404_RS11425	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H5404_RS11430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5404_RS11430	COG0047	phosphoribosylformylglycinamidine synthase activity
H5404_RS11455	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5404_RS11460	COG2252	PERMEase
H5404_RS11465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H5404_RS11470	COG1073	alpha beta
H5404_RS11480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H5404_RS11485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H5404_RS11490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5404_RS11495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5404_RS11495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5404_RS11515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5404_RS11520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H5404_RS11525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H5404_RS11530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H5404_RS11535	COG0142	geranyltranstransferase activity
H5404_RS11540	COG1722	exodeoxyribonuclease VII activity
H5404_RS11545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5404_RS11550	COG2885	chlorophyll binding
H5404_RS11555	COG0301	tRNA thio-modification
H5404_RS11555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5404_RS11560	COG0583	DNA-binding transcription factor activity
H5404_RS11570	COG2363	Small membrane protein
H5404_RS11575	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H5404_RS11585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5404_RS11590	COG1611	Belongs to the LOG family
H5404_RS11605	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5404_RS11605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5404_RS11615	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H5404_RS11620	COG1464	Belongs to the NlpA lipoprotein family
H5404_RS11625	COG2011	ABC-type metal ion transport system permease component
H5404_RS11630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5404_RS11635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H5404_RS11645	COG1263	PTS System
H5404_RS11645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5404_RS11650	COG0366	Alpha amylase catalytic
H5404_RS11665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5404_RS11670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5404_RS11675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5404_RS11680	COG0321	lipoyl(octanoyl) transferase activity
H5404_RS11685	COG2921	Belongs to the UPF0250 family
H5404_RS11690	COG1686	Belongs to the peptidase S11 family
H5404_RS11695	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5404_RS11700	COG0772	Belongs to the SEDS family
H5404_RS11705	COG0768	penicillin binding
H5404_RS11710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H5404_RS11715	COG0799	negative regulation of ribosome biogenesis
H5404_RS11720	COG1466	dna polymerase III delta subunit
H5404_RS11725	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H5404_RS11730	COG0495	leucyl-tRNA aminoacylation
H5404_RS11735	COG2888	peptidyl-tyrosine sulfation
H5404_RS11740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H5404_RS11745	COG4535	Mg2 and Co2 transporter CorC
H5404_RS11750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H5404_RS11755	COG1702	phosphate starvation-inducible protein PhoH
H5404_RS11760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5404_RS11765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5404_RS11880	COG0012	GTP binding
H5404_RS11885	COG0193	aminoacyl-tRNA hydrolase activity
H5404_RS11890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5404_RS11895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H5404_RS11900	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H5404_RS11905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H5404_RS11910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H5404_RS11915	COG2890	protein-(glutamine-N5) methyltransferase activity
H5404_RS11920	COG3094	Invasion gene expression up-regulator, SirB
H5404_RS11925	COG2912	Transglutaminase-like superfamily
H5404_RS11930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H5404_RS11935	COG0737	Belongs to the 5'-nucleotidase family
H5404_RS11945	COG1187	pseudouridine synthase activity
H5404_RS11950	COG2840	Smr protein MutS2
H5404_RS11985	COG2217	Heavy metal translocating P-type atpase
H5404_RS11985	COG2608	mercury ion transmembrane transporter activity
H5404_RS11995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H5404_RS12000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5404_RS12050	COG0835	chemotaxis
H5404_RS12050	COG0784	Response regulator, receiver
H5404_RS12055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5404_RS12060	COG1815	bacterial-type flagellum-dependent cell motility
H5404_RS12065	COG1558	bacterial-type flagellum-dependent cell motility
H5404_RS12075	COG1749	Flagellar hook protein flgE
H5404_RS12080	COG4787	bacterial-type flagellum-dependent cell motility
H5404_RS12090	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H5404_RS12095	COG1706	bacterial-type flagellum-dependent cell motility
H5404_RS12100	COG1705	Flagellar rod assembly protein muramidase FlgJ
H5404_RS12100	COG3951	Flagellar rod assembly protein muramidase FlgJ
H5404_RS12110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_RS12115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_RS12120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_RS12125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_RS12130	COG2190	(PTS) system
H5404_RS12135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5404_RS12140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_RS12145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5404_RS12150	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H5404_RS12155	COG3115	cell septum assembly
H5404_RS12160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5404_RS12180	COG0330	HflC and HflK could
H5404_RS12185	COG3118	belongs to the thioredoxin family
H5404_RS12190	COG0300	oxidoreductase activity
H5404_RS12195	COG1090	epimerase
H5404_RS12220	COG0622	Phosphoesterase
H5404_RS12240	COG3710	Transcriptional regulator
H5404_RS12245	COG0326	Molecular chaperone. Has ATPase activity
H5404_RS12250	COG0563	adenylate kinase activity
H5404_RS12255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H5404_RS12260	COG3104	oligopeptide transport
H5404_RS12265	COG0250	Participates in transcription elongation, termination and antitermination
H5404_RS12270	COG0367	asparagine synthase
H5404_RS12275	COG4651	solute:proton antiporter activity
H5404_RS12275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5404_RS12280	COG1940	carbohydrate kinase activity
H5404_RS12280	COG1846	Transcriptional regulator
H5404_RS12285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H5404_RS12290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5404_RS12290	COG1263	PTS System
H5404_RS12295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5404_RS12300	COG0735	belongs to the Fur family
H5404_RS12320	COG0596	Alpha beta hydrolase
H5404_RS12325	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H5404_RS12330	COG0033	Phosphoglucomutase
H5404_RS12340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H5404_RS12355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H5404_RS12360	COG1053	succinate dehydrogenase
H5404_RS12365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5404_RS12370	COG0567	Dehydrogenase, E1 component
H5404_RS12375	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5404_RS12380	COG0045	succinate-CoA ligase (ADP-forming) activity
H5404_RS12390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5404_RS12395	COG1121	(ABC) transporter
H5404_RS12400	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H5404_RS12405	COG4977	sequence-specific DNA binding
H5404_RS12410	COG1918	ferrous iron import across plasma membrane
H5404_RS12430	COG0018	arginyl-trna synthetase
H5404_RS12435	COG3102	Protein conserved in bacteria
H5404_RS12440	COG0788	formyltetrahydrofolate deformylase activity
H5404_RS12445	COG1199	ATP-dependent helicase activity
H5404_RS12450	COG1214	PFAM Peptidase M22, glycoprotease
H5404_RS12465	COG2267	carboxylic ester hydrolase activity
H5404_RS12470	COG0318	PFAM AMP-dependent synthetase and ligase
H5404_RS12475	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H5404_RS12480	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H5404_RS12485	COG2894	cell division
H5404_RS12490	COG0850	regulation of cytokinetic process
H5404_RS12495	COG3100	YcgL domain-containing protein
H5404_RS12500	COG2951	lytic endotransglycosylase activity
H5404_RS12505	COG0583	DNA-binding transcription factor activity
H5404_RS12510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5404_RS12515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H5404_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS12545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5404_RS12570	COG2986	histidine ammonia-lyase
H5404_RS12575	COG1216	Glycosyl transferase, family 2
H5404_RS12580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5404_RS12595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5404_RS12600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5404_RS12635	COG1253	flavin adenine dinucleotide binding
H5404_RS12640	COG0513	Belongs to the DEAD box helicase family
H5404_RS12645	COG0569	domain protein
H5404_RS12650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5404_RS12665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H5404_RS12670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H5404_RS12675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H5404_RS12680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H5404_RS12690	COG2204	response regulator
H5404_RS12705	COG0544	peptidyl-prolyl cis-trans isomerase activity
H5404_RS12715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H5404_RS12720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H5404_RS12725	COG0776	regulation of translation
H5404_RS12730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5404_RS12750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H5404_RS12755	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H5404_RS12760	COG0436	Aminotransferase
H5404_RS12765	COG1169	isochorismate synthase
H5404_RS12770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H5404_RS12775	COG0596	Alpha beta hydrolase
H5404_RS12780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H5404_RS12800	COG2855	membrane
H5404_RS12805	COG0477	Major facilitator Superfamily
H5404_RS12855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_RS12880	COG1522	sequence-specific DNA binding
H5404_RS12890	COG1946	Acyl-CoA thioesterase
H5404_RS12895	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H5404_RS12910	COG2199	diguanylate cyclase activity
H5404_RS12920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5404_RS12925	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H5404_RS12930	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H5404_RS12935	COG0517	IMP dehydrogenase activity
H5404_RS12935	COG0516	GMP reductase activity
H5404_RS12960	COG0537	adenosine 5'-monophosphoramidase activity
H5404_RS12985	COG3150	esterase
H5404_RS12990	COG1252	NADH dehydrogenase
H5404_RS13005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5404_RS13015	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5404_RS13020	COG1136	(ABC) transporter
H5404_RS13025	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5404_RS13035	COG0658	competence protein
H5404_RS13035	COG2333	competence protein COMEC
H5404_RS13040	COG1132	(ABC) transporter
H5404_RS13045	COG1663	tetraacyldisaccharide 4'-kinase activity
H5404_RS13055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H5404_RS13060	COG2719	SpoVR family
H5404_RS13065	COG2718	Belongs to the UPF0229 family
H5404_RS13070	COG2766	serine protein kinase
H5404_RS13075	COG3013	Belongs to the UPF0304 family
H5404_RS13085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H5404_RS13095	COG1882	Formate acetyltransferase
H5404_RS13135	COG0708	Exodeoxyribonuclease III
H5404_RS13145	COG3923	Primosomal replication protein n
H5404_RS13150	COG0730	response to heat
H5404_RS13155	COG1199	ATP-dependent helicase activity
H5404_RS13165	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H5404_RS13170	COG1187	pseudouridine synthase activity
H5404_RS13180	COG1278	Cold shock
H5404_RS13185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5404_RS13190	COG0542	response to heat
H5404_RS13200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H5404_RS13205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H5404_RS13210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5404_RS13220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5404_RS13230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5404_RS13235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H5404_RS13240	COG0297	glycogen (starch) synthase activity
H5404_RS13260	COG3070	regulator of competence-specific genes
H5404_RS13265	COG1609	Transcriptional regulator
H5404_RS13270	COG3381	protein complex oligomerization
H5404_RS13275	COG0745	RESPONSE REGULATOR receiver
H5404_RS13280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H5404_RS13285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5404_RS13290	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H5404_RS13295	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H5404_RS13300	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H5404_RS13320	COG4067	protein conserved in archaea
H5404_RS13320	COG0189	ligase activity
H5404_RS13325	COG0500	methyltransferase
H5404_RS13330	COG4106	trans-aconitate 2-methyltransferase activity
H5404_RS13335	COG1801	Protein of unknown function DUF72
H5404_RS13340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H5404_RS13345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H5404_RS13350	COG0840	transmembrane signaling receptor activity
H5404_RS13355	COG0632	four-way junction helicase activity
H5404_RS13360	COG2255	four-way junction helicase activity
H5404_RS13365	COG1271	oxidase subunit
H5404_RS13370	COG1294	oxidase, subunit
H5404_RS13375	COG4890	Cyd operon protein YbgT
H5404_RS13385	COG0824	Thioesterase
H5404_RS13390	COG0811	peptide transport
H5404_RS13405	COG0823	Involved in the tonB-independent uptake of proteins
H5404_RS13410	COG2885	chlorophyll binding
H5404_RS13415	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H5404_RS13420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H5404_RS13430	COG3766	membrane
H5404_RS13440	COG0754	glutathionylspermidine amidase activity
H5404_RS13450	COG0784	Response regulator, receiver
H5404_RS13450	COG5002	protein histidine kinase activity
H5404_RS13465	COG0582	viral genome integration into host DNA
H5404_RS13500	COG0328	RNA-DNA hybrid ribonuclease activity
H5404_RS13515	COG2003	Belongs to the UPF0758 family
H5404_RS13545	COG0732	type I restriction modification DNA specificity domain
H5404_RS13560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H5404_RS13580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5404_RS13585	COG0840	transmembrane signaling receptor activity
H5404_RS13590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_RS13595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_RS13620	COG3568	Endonuclease Exonuclease Phosphatase
H5404_RS13635	COG0583	DNA-binding transcription factor activity
H5404_RS13645	COG0686	Belongs to the AlaDH PNT family
H5404_RS13655	COG1674	ftsk spoiiie
H5404_RS13660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5404_RS13665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5404_RS13670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H5404_RS13685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5404_RS13690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5404_RS13695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H5404_RS13700	COG0156	8-amino-7-oxononanoate synthase activity
H5404_RS13710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H5404_RS13720	COG0501	Belongs to the peptidase M48B family
H5404_RS13730	COG0300	oxidoreductase activity
H5404_RS13745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5404_RS13765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H5404_RS13770	COG2915	High frequency lysogenization protein hflD homolog
H5404_RS13775	COG0482	sulfurtransferase activity
H5404_RS13785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5404_RS13795	COG1757	Na H antiporter
H5404_RS13810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H5404_RS13815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5404_RS13820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H5404_RS13825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H5404_RS13825	COG0131	Imidazoleglycerol-phosphate dehydratase
H5404_RS13830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H5404_RS13835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H5404_RS13840	COG0107	imidazoleglycerol-phosphate synthase activity
H5404_RS13845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5404_RS13845	COG0140	phosphoribosyl-ATP diphosphatase activity
H5404_RS13850	COG3012	SEC-C Motif Domain Protein
H5404_RS13855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H5404_RS13860	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5404_RS13865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5404_RS13870	COG0215	cysteine-tRNA ligase activity
H5404_RS13875	COG1435	thymidine kinase activity
H5404_RS13880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H5404_RS13905	COG2116	formate transmembrane transporter activity
H5404_RS13915	COG0390	transport system, permease component
H5404_RS13920	COG4459	periplasmic nitrate reductase
H5404_RS13925	COG3005	denitrification pathway
H5404_RS13930	COG0243	molybdopterin cofactor binding
H5404_RS13945	COG1227	inorganic diphosphatase activity
H5404_RS13955	COG4172	Belongs to the ABC transporter superfamily
H5404_RS13965	COG4171	peptide transport system, permease
H5404_RS13980	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H5404_RS13985	COG1842	Phage shock protein A
H5404_RS13995	COG1983	PspC domain protein
H5404_RS14000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_RS14015	COG2818	Glycosylase
H5404_RS14020	COG5380	lipid catabolic process
H5404_RS14025	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H5404_RS14030	COG0626	cystathionine gamma-synthase activity
H5404_RS14040	COG0733	neurotransmitter:sodium symporter activity
H5404_RS14050	COG0564	pseudouridine synthase activity
H5404_RS14060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5404_RS14065	COG1151	hydroxylamine reductase activity
H5404_RS14070	COG3604	Transcriptional regulator
H5404_RS14080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H5404_RS14085	COG4136	ATPase activity
H5404_RS14090	COG4135	transport system, permease component
H5404_RS14095	COG4134	Bacterial extracellular solute-binding protein
H5404_RS14100	COG0398	Pfam SNARE associated Golgi protein
H5404_RS14110	COG0493	'glutamate synthase
H5404_RS14135	COG3313	Fe-S protein
H5404_RS14160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H5404_RS14180	COG1061	Type III restriction enzyme res subunit
H5404_RS14185	COG1187	pseudouridine synthase activity
H5404_RS14190	COG2814	Major facilitator Superfamily
H5404_RS14220	COG3005	denitrification pathway
H5404_RS14225	COG0702	epimerase
H5404_RS14230	COG0534	Mate efflux family protein
H5404_RS14235	COG4181	ATPase activity
H5404_RS14250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5404_RS14265	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5404_RS14270	COG3273	potassium ion transport
H5404_RS14270	COG2985	domain, Protein
H5404_RS14275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5404_RS14285	COG1737	Transcriptional regulator
H5404_RS14290	COG0076	glutamate decarboxylase activity
H5404_RS14300	COG2431	L-lysine efflux transmembrane transporter activity
H5404_RS14310	COG3070	regulator of competence-specific genes
H5404_RS14325	COG4191	Histidine kinase
H5404_RS14325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_RS14335	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H5404_RS14340	COG3048	D-serine ammonia-lyase activity
H5404_RS14345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H5404_RS14350	COG4988	ABC transporter
H5404_RS14355	COG0492	ferredoxin-NADP+ reductase activity
H5404_RS14380	COG0471	metal ion transport
H5404_RS14385	COG2949	membrane
H5404_RS14390	COG0281	malic enzyme
H5404_RS14395	COG1643	Atp-dependent helicase
H5404_RS14400	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H5404_RS14415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H5404_RS14450	COG0277	FAD linked oxidase domain protein
H5404_RS14450	COG0247	lactate metabolic process
H5404_RS14465	COG2986	histidine ammonia-lyase
H5404_RS14470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H5404_RS14475	COG0010	Belongs to the arginase family
H5404_RS14480	COG1228	amidohydrolase
H5404_RS14485	COG2188	Transcriptional regulator
H5404_RS14500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H5404_RS14510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H5404_RS14520	COG0393	Putative heavy-metal-binding
H5404_RS14550	COG3706	GGDEF domain
H5404_RS14555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H5404_RS14560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5404_RS14560	COG0072	phenylalanine-tRNA ligase activity
H5404_RS14570	COG0776	regulation of translation
H5404_RS14580	COG0500	methyltransferase
H5404_RS14585	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H5404_RS14590	COG0295	cytidine deaminase activity
H5404_RS14595	COG1346	cytolysis
H5404_RS14600	COG1380	Effector of murein hydrolase LrgA
H5404_RS14605	COG2925	Exonuclease
H5404_RS14610	COG1823	symporter activity
H5404_RS14615	COG0702	epimerase
H5404_RS14620	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H5404_RS14625	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H5404_RS14635	COG2062	phosphohistidine phosphatase, SixA
H5404_RS14645	COG2988	succinylglutamate desuccinylase activity
H5404_RS14650	COG4139	cobalamin transport
H5404_RS14655	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H5404_RS14675	COG0583	DNA-binding transcription factor activity
H5404_RS14695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H5404_RS14700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5404_RS14705	COG3475	LICD family
H5404_RS14710	COG1451	nucleotide metabolic process
H5404_RS14715	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H5404_RS14745	COG3938	Belongs to the proline racemase family
H5404_RS14760	COG2423	ornithine cyclodeaminase activity
H5404_RS14765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5404_RS14770	COG3842	ATPase activity
H5404_RS14775	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5404_RS14780	COG1177	transmembrane transport
H5404_RS14790	COG3291	Pkd domain containing protein
H5404_RS14805	COG0444	Belongs to the ABC transporter superfamily
H5404_RS14810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5404_RS14815	COG0601	transmembrane transport
H5404_RS14825	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5404_RS14835	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H5404_RS14845	COG0625	glutathione transferase activity
H5404_RS14900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H5404_RS14905	COG1127	ABC transporter
H5404_RS14920	COG3264	Mechanosensitive ion channel
H5404_RS14920	COG1511	domain protein
H5404_RS14925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5404_RS14930	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H5404_RS14935	COG0583	DNA-binding transcription factor activity
H5404_RS14970	COG0471	metal ion transport
H5404_RS14975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_RS14975	COG4191	Histidine kinase
H5404_RS14985	COG5001	Diguanylate cyclase
H5404_RS14985	COG3300	MHYT domain
H5404_RS14995	COG1280	lysine exporter protein (LysE YggA)
H5404_RS15000	COG1328	CTP reductase activity
H5404_RS15005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H5404_RS15015	COG0861	Integral membrane protein TerC family
H5404_RS15020	COG0739	heme binding
H5404_RS15065	COG3501	Rhs element vgr protein
H5404_RS15090	COG0515	serine threonine protein kinase
H5404_RS15125	COG1522	sequence-specific DNA binding
H5404_RS15235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H5404_RS15245	COG0814	amino acid
H5404_RS15265	COG1132	(ABC) transporter
H5404_RS15270	COG1132	(ABC) transporter
H5404_RS15295	COG0443	Heat shock 70 kDa protein
H5404_RS15300	COG0443	Heat shock 70 kDa protein
H5404_RS15310	COG3706	GGDEF domain
H5404_RS15340	COG0243	molybdopterin cofactor binding
H5404_RS15345	COG0437	4 iron, 4 sulfur cluster binding
H5404_RS15350	COG3302	dmso reductase anchor subunit
H5404_RS15365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5404_RS15370	COG1643	Atp-dependent helicase
H5404_RS15385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5404_RS15395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5404_RS15400	COG1215	transferase activity, transferring glycosyl groups
H5404_RS15405	COG0438	transferase activity, transferring glycosyl groups
H5404_RS15435	COG0438	transferase activity, transferring glycosyl groups
H5404_RS15445	COG2204	response regulator
H5404_RS15475	COG1793	dna ligase
H5404_RS15485	COG0534	Mate efflux family protein
H5404_RS15490	COG0307	riboflavin synthase, alpha
H5404_RS15500	COG3001	Fructosamine kinase
H5404_RS15505	COG2201	protein-glutamate methylesterase activity
H5404_RS15510	COG3706	GGDEF domain
H5404_RS15520	COG0791	NLP P60 protein
H5404_RS15525	COG0840	transmembrane signaling receptor activity
H5404_RS15525	COG3290	protein histidine kinase activity
H5404_RS15560	COG3148	PFAM DTW domain containing protein
H5404_RS15565	COG1940	carbohydrate kinase activity
H5404_RS15575	COG0303	'Molybdopterin
H5404_RS15580	COG0746	molybdenum cofactor guanylyltransferase activity
H5404_RS15585	COG3842	ATPase activity
H5404_RS15600	COG2204	response regulator
H5404_RS15605	COG4191	Histidine kinase
H5404_RS15610	COG0488	(ABC) transporter
H5404_RS15615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5404_RS15635	COG3381	protein complex oligomerization
H5404_RS15645	COG3383	formate dehydrogenase (NAD+) activity
H5404_RS15645	COG0243	molybdopterin cofactor binding
H5404_RS15650	COG0437	4 iron, 4 sulfur cluster binding
H5404_RS15675	COG0004	ammonium transporteR
H5404_RS15685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H5404_RS15690	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H5404_RS15700	COG1177	transmembrane transport
H5404_RS15710	COG3842	ATPase activity
H5404_RS15730	COG0037	tRNA processing
H5404_RS15735	COG0589	response to stress
H5404_RS15740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5404_RS15755	COG2217	Heavy metal translocating P-type atpase
H5404_RS15765	COG2010	Cytochrome c
H5404_RS15780	COG3278	Belongs to the heme-copper respiratory oxidase family
H5404_RS15795	COG2205	protein histidine kinase activity
H5404_RS15795	COG0784	Response regulator, receiver
H5404_RS15815	COG3120	sequence-specific DNA binding
H5404_RS15820	COG1067	ATP-dependent peptidase activity
H5404_RS15825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5404_RS15840	COG0488	(ABC) transporter
H5404_RS15850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H5404_RS15850	COG0116	Belongs to the methyltransferase superfamily
H5404_RS15860	COG0167	dihydroorotate dehydrogenase activity
H5404_RS15865	COG2902	Dehydrogenase
H5404_RS15875	COG0308	aminopeptidase N
H5404_RS15890	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H5404_RS15895	COG1956	GAF domain-containing protein
H5404_RS15900	COG1132	(ABC) transporter
H5404_RS15905	COG2995	paraquat-inducible protein a
H5404_RS15910	COG3008	intermembrane lipid transfer
H5404_RS15915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5404_RS15915	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H5404_RS15935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5404_RS15940	COG1666	GTP binding
H5404_RS15950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_RS15955	COG4597	amino acid ABC transporter
H5404_RS15960	COG0765	amino acid transport
H5404_RS15965	COG1126	abc transporter atp-binding protein
H5404_RS15970	COG0670	Belongs to the BI1 family
H5404_RS15980	COG2920	part of a sulfur-relay system
H5404_RS15985	COG1254	Belongs to the acylphosphatase family
H5404_RS15990	COG0840	transmembrane signaling receptor activity
H5404_RS15995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H5404_RS16035	COG3706	GGDEF domain
H5404_RS16040	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5404_RS16045	COG0602	queuosine metabolic process
H5404_RS16050	COG0561	phosphatase activity
H5404_RS16075	COG2828	Protein conserved in bacteria
H5404_RS16085	COG0372	Belongs to the citrate synthase family
H5404_RS16090	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H5404_RS16120	COG0730	response to heat
H5404_RS16140	COG0457	Tetratricopeptide repeat
H5404_RS16210	COG4790	Type iii secretion
H5404_RS16215	COG4794	Type iii secretion
H5404_RS16220	COG4791	protein targeting
H5404_RS16225	COG4792	protein secretion
H5404_RS16235	COG1073	alpha beta
H5404_RS16240	COG1073	alpha beta
H5404_RS16270	COG3177	Filamentation induced by cAMP protein fic
H5404_RS16290	COG4669	(LipO)protein
H5404_RS16360	COG1012	belongs to the aldehyde dehydrogenase family
H5404_RS16365	COG3284	Transcriptional regulator
H5404_RS16380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H5404_RS16385	COG0363	glucosamine-6-phosphate deaminase activity
H5404_RS16390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H5404_RS16395	COG4565	transcriptional regulatory protein
H5404_RS16400	COG3290	protein histidine kinase activity
H5404_RS16415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_RS16430	COG1858	cytochrome C peroxidase
H5404_RS16435	COG0527	aspartate kinase activity
H5404_RS16440	COG0662	Cupin 2, conserved barrel domain protein
H5404_RS16445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5404_RS16450	COG0456	acetyltransferase
H5404_RS16455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5404_RS16470	COG4175	Glycine betaine
H5404_RS16475	COG4176	ABC-type proline glycine betaine transport system permease component
H5404_RS16480	COG2113	Glycine betaine
H5404_RS16500	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS16510	COG0745	RESPONSE REGULATOR receiver
H5404_RS16515	COG0642	Histidine kinase
H5404_RS16520	COG1368	sulfuric ester hydrolase activity
H5404_RS16545	COG1115	amino acid carrier protein
H5404_RS16555	COG1280	lysine exporter protein (LysE YggA)
H5404_RS16560	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H5404_RS16565	COG3550	peptidyl-serine autophosphorylation
H5404_RS16570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5404_RS16580	COG3328	transposase activity
H5404_RS16625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5404_RS16630	COG0840	transmembrane signaling receptor activity
H5404_RS16635	COG4580	involved in the transport of maltose and maltodextrins
H5404_RS16640	COG1874	Beta-galactosidase
H5404_RS16650	COG3833	ABC-type maltose transport systems, permease component
H5404_RS16655	COG1175	transmembrane transport
H5404_RS16660	COG2182	Extracellular solute-binding protein
H5404_RS16670	COG1609	Transcriptional regulator
H5404_RS16685	COG3328	transposase activity
H5404_RS16730	COG3328	transposase activity
H5404_RS16750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5404_RS16765	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H5404_RS16780	COG1560	Kdo2-lipid A biosynthetic process
H5404_RS16785	COG0531	amino acid
H5404_RS16795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H5404_RS16800	COG3063	Type IV pilus biogenesis stability protein PilW
H5404_RS16830	COG0110	maltose O-acetyltransferase activity
H5404_RS16850	COG2315	Protein conserved in bacteria
H5404_RS16855	COG1846	Transcriptional regulator
H5404_RS16870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H5404_RS16880	COG2771	luxR family
H5404_RS16880	COG2200	EAL domain
H5404_RS16885	COG1227	inorganic diphosphatase activity
H5404_RS16890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5404_RS16895	COG1012	belongs to the aldehyde dehydrogenase family
H5404_RS16900	COG2957	Belongs to the agmatine deiminase family
H5404_RS16910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5404_RS16915	COG1012	belongs to the aldehyde dehydrogenase family
H5404_RS16920	COG1396	sequence-specific DNA binding
H5404_RS16920	COG1917	Cupin 2, conserved barrel domain protein
H5404_RS16925	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H5404_RS16930	COG0174	glutamine synthetase
H5404_RS16935	COG1757	Na H antiporter
H5404_RS16955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5404_RS16960	COG1280	lysine exporter protein (LysE YggA)
H5404_RS17010	COG2801	Transposase and inactivated derivatives
H5404_RS17060	COG0456	acetyltransferase
H5404_RS17125	COG2801	Transposase and inactivated derivatives
H5404_RS17160	COG0346	lactoylglutathione lyase activity
H5404_RS17165	COG2801	Transposase and inactivated derivatives
H5404_RS17255	COG1280	lysine exporter protein (LysE YggA)
H5404_RS17450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5404_RS17460	COG3768	UPF0283 membrane protein
H5404_RS17465	COG3106	COG3106 Predicted ATPase
H5404_RS17480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5404_RS17485	COG2205	protein histidine kinase activity
H5404_RS17485	COG0784	Response regulator, receiver
H5404_RS17495	COG0494	nUDIX hydrolase
H5404_RS17500	COG0814	amino acid
H5404_RS17505	COG1760	l-serine dehydratase
H5404_RS17510	COG2200	EAL domain
H5404_RS17520	COG0720	synthase
H5404_RS17525	COG0840	transmembrane signaling receptor activity
H5404_RS17530	COG0017	Asparaginyl-tRNA synthetase
H5404_RS17540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5404_RS17555	COG1448	Aminotransferase
H5404_RS17575	COG0840	transmembrane signaling receptor activity
H5404_RS17580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5404_RS17585	COG1846	Transcriptional regulator
H5404_RS17610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H5404_RS17625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5404_RS17630	COG3108	Peptidase M15
H5404_RS17635	COG2989	Protein conserved in bacteria
H5404_RS17660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5404_RS17670	COG3088	subunit of a heme lyase
H5404_RS17670	COG4235	cytochrome complex assembly
H5404_RS17680	COG1138	Cytochrome C-type biogenesis protein
H5404_RS17685	COG3301	Polysulphide reductase, NrfD
H5404_RS17690	COG0437	4 iron, 4 sulfur cluster binding
H5404_RS17700	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H5404_RS17720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5404_RS17725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5404_RS17730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5404_RS17755	COG0019	diaminopimelate decarboxylase activity
H5404_RS17795	COG0322	excinuclease ABC activity
H5404_RS17800	COG2197	response regulator
H5404_RS17805	COG0417	DNA replication proofreading
H5404_RS17815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5404_RS17820	COG3099	Belongs to the UPF0263 family
H5404_RS17825	COG1187	pseudouridine synthase activity
H5404_RS17835	COG0009	L-threonylcarbamoyladenylate synthase
H5404_RS17840	COG0613	PHP domain protein
H5404_RS17850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5404_RS17855	COG0512	Glutamine amidotransferase of anthranilate synthase
H5404_RS17860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5404_RS17865	COG0134	indole-3-glycerol-phosphate synthase activity
H5404_RS17865	COG0135	phosphoribosylanthranilate isomerase activity
H5404_RS17870	COG0133	tryptophan synthase activity
H5404_RS17875	COG0159	tryptophan synthase activity
H5404_RS17880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5404_RS17885	COG0318	PFAM AMP-dependent synthetase and ligase
H5404_RS17895	COG1301	dicarboxylic acid transport
H5404_RS18020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5404_RS18245	COG2917	probably involved in intracellular septation
H5404_RS18255	COG2350	Protein conserved in bacteria
H5404_RS18280	COG2842	Transposition protein
H5404_RS18530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H5404_RS18535	COG0583	DNA-binding transcription factor activity
H5404_RS18550	COG5001	Diguanylate cyclase
H5404_RS18550	COG2203	Gaf domain
H5404_RS18550	COG3706	GGDEF domain
H5404_RS18550	COG4251	negative regulation of phosphorylation
H5404_RS18555	COG1032	radical SAM domain protein
H5404_RS18560	COG0840	transmembrane signaling receptor activity
H5404_RS18565	COG0745	RESPONSE REGULATOR receiver
H5404_RS18570	COG3850	Histidine kinase
H5404_RS18570	COG5002	protein histidine kinase activity
H5404_RS18615	COG1917	Cupin 2, conserved barrel domain protein
H5404_RS18615	COG2207	Transcriptional regulator
H5404_RS18620	COG1335	isochorismatase
H5404_RS18625	COG1136	(ABC) transporter
H5404_RS18625	COG0577	efflux transmembrane transporter activity
H5404_RS18630	COG0577	efflux transmembrane transporter activity
H5404_RS18630	COG1136	(ABC) transporter
H5404_RS18635	COG0577	efflux transmembrane transporter activity
H5404_RS18635	COG1136	(ABC) transporter
H5404_RS18645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_RS18660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5404_RS18675	COG3118	belongs to the thioredoxin family
H5404_RS18680	COG4232	protein-disulfide reductase activity
H5404_RS18720	COG2863	cytochrome
H5404_RS18725	COG3258	Cytochrome c
H5404_RS18730	COG2995	paraquat-inducible protein a
H5404_RS18735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5404_RS18735	COG3008	intermembrane lipid transfer
H5404_RS18745	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H5404_RS18755	COG0463	Glycosyl transferase, family 2
H5404_RS18770	COG4166	transmembrane transport
H5404_RS18775	COG0284	orotidine-5'-phosphate decarboxylase activity
H5404_RS18780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H5404_RS18785	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H5404_RS18795	COG0539	negative regulation of cytoplasmic translation
H5404_RS18800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H5404_RS18805	COG0616	signal peptide processing
H5404_RS18810	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS18825	COG0587	DNA-directed DNA polymerase activity
H5404_RS18830	COG0784	Response regulator, receiver
H5404_RS18830	COG0835	chemotaxis
H5404_RS18835	COG1940	carbohydrate kinase activity
H5404_RS18840	COG0469	pyruvate kinase activity
H5404_RS18845	COG4667	esterase of the alpha-beta hydrolase superfamily
H5404_RS18860	COG0733	neurotransmitter:sodium symporter activity
H5404_RS18875	COG1263	PTS System
H5404_RS18875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5404_RS18880	COG0084	hydrolase, TatD family'
H5404_RS18890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H5404_RS18895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5404_RS18925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5404_RS18930	COG0416	fatty acid biosynthetic process
H5404_RS18940	COG1399	metal-binding, possibly nucleic acid-binding protein
H5404_RS18945	COG0424	maF-like protein
H5404_RS18950	COG0564	pseudouridine synthase activity
H5404_RS18955	COG1530	ribonuclease E activity
H5404_RS18960	COG0659	secondary active sulfate transmembrane transporter activity
H5404_RS18965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5404_RS18970	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H5404_RS18980	COG0572	uridine kinase
H5404_RS18985	COG0489	protein tyrosine kinase activity
H5404_RS18990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5404_RS18990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5404_RS19000	COG2186	Transcriptional regulator
H5404_RS19005	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5404_RS19010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H5404_RS19015	COG3318	Belongs to the UPF0149 family
H5404_RS19015	COG3012	SEC-C Motif Domain Protein
H5404_RS19020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5404_RS19030	COG0366	Alpha amylase catalytic
H5404_RS19035	COG1122	ATPase activity
H5404_RS19040	COG4120	Belongs to the binding-protein-dependent transport system permease family
H5404_RS19050	COG3092	negative regulation of chromosome organization
H5404_RS19055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H5404_RS19060	COG0280	phosphate acetyltransferase
H5404_RS19060	COG0857	belongs to the CobB CobQ family
H5404_RS19065	COG3174	membrane
H5404_RS19075	COG0435	Glutathione S-transferase
H5404_RS19085	COG0444	Belongs to the ABC transporter superfamily
H5404_RS19090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5404_RS19095	COG0601	transmembrane transport
H5404_RS19105	COG0314	molybdopterin synthase activity
H5404_RS19110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H5404_RS19115	COG0315	cyclic pyranopterin monophosphate synthase activity
H5404_RS19120	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5404_RS19125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5404_RS19130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H5404_RS19135	COG2198	Histidine kinase
H5404_RS19140	COG2204	response regulator
H5404_RS19145	COG0556	nucleotide-excision repair
H5404_RS19155	COG4657	Part of a membrane complex involved in electron transport
H5404_RS19160	COG2878	Part of a membrane complex involved in electron transport
H5404_RS19165	COG4656	Part of a membrane complex involved in electron transport
H5404_RS19170	COG4658	electron transport chain
H5404_RS19175	COG4659	FMN binding
H5404_RS19180	COG4660	Part of a membrane complex involved in electron transport
H5404_RS19185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5404_RS19190	COG0346	lactoylglutathione lyase activity
H5404_RS19200	COG2885	chlorophyll binding
H5404_RS19205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5404_RS19210	COG2056	Na+-H+ antiporter family
H5404_RS19220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H5404_RS19240	COG1012	belongs to the aldehyde dehydrogenase family
H5404_RS19240	COG1454	alcohol dehydrogenase
H5404_RS19245	COG2095	MarC family integral membrane protein
H5404_RS19250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5404_RS19255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H5404_RS19260	COG1757	Na H antiporter
H5404_RS19275	COG3081	Nucleoid-associated protein
H5404_RS19280	COG3082	Protein of unknown function (DUF1414)
H5404_RS19285	COG3083	sulfuric ester hydrolase activity
H5404_RS19295	COG0123	including yeast histone deacetylase and acetoin utilization protein
H5404_RS19310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5404_RS19315	COG0778	Nitroreductase
H5404_RS19320	COG1902	pentaerythritol trinitrate reductase activity
H5404_RS19320	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5404_RS19325	COG0616	signal peptide processing
H5404_RS19330	COG0252	asparaginase activity
H5404_RS19335	COG3139	Protein of unknown function (DUF1315)
H5404_RS19345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5404_RS19350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5404_RS19365	COG2226	methyltransferase
H5404_RS19380	COG1785	Belongs to the alkaline phosphatase family
H5404_RS19390	COG0346	lactoylglutathione lyase activity
H5404_RS19395	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H5404_RS19400	COG0668	transmembrane transport
H5404_RS19405	COG2983	Belongs to the UPF0260 family
H5404_RS19410	COG2261	transglycosylase associated protein
H5404_RS19425	COG3681	Belongs to the UPF0597 family
H5404_RS19430	COG0251	oxidation-reduction process
H5404_RS19435	COG0814	amino acid
H5404_RS19440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H5404_RS19445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5404_RS19450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H5404_RS19460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H5404_RS19465	COG2832	Protein of unknown function (DUF454)
H5404_RS19470	COG0745	RESPONSE REGULATOR receiver
H5404_RS19475	COG0583	DNA-binding transcription factor activity
H5404_RS19480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H5404_RS19485	COG1286	toxin biosynthetic process
H5404_RS19490	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H5404_RS19495	COG0285	dihydrofolate synthase activity
H5404_RS19500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H5404_RS19505	COG0101	tRNA pseudouridine synthase activity
H5404_RS19515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H5404_RS19520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5404_RS19525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5404_RS19530	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H5404_RS19530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5404_RS19535	COG0431	NADPH-dependent FMN reductase
H5404_RS19545	COG3101	peptidyl-lysine hydroxylation
H5404_RS19550	COG2860	membrane
H5404_RS19555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H5404_RS19560	COG2890	protein-(glutamine-N5) methyltransferase activity
H5404_RS19565	COG2840	Smr protein MutS2
H5404_RS19570	COG2062	phosphohistidine phosphatase, SixA
H5404_RS19585	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5404_RS19585	COG1024	Enoyl-CoA hydratase
H5404_RS19590	COG0183	Belongs to the thiolase family
H5404_RS19605	COG2067	long-chain fatty acid transport protein
H5404_RS19615	COG2853	Lipoprotein
H5404_RS19630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5404_RS19635	COG1138	Cytochrome C-type biogenesis protein
H5404_RS19640	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H5404_RS19645	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5404_RS19650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5404_RS19655	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5404_RS19660	COG4133	protoheme IX ABC transporter activity
H5404_RS19670	COG0835	chemotaxis
H5404_RS19680	COG1192	Involved in chromosome partitioning
H5404_RS19685	COG2201	protein-glutamate methylesterase activity
H5404_RS19690	COG0643	Histidine kinase
H5404_RS19690	COG0784	Response regulator, receiver
H5404_RS19690	COG2198	Histidine kinase
H5404_RS19695	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H5404_RS19735	COG1987	bacterial-type flagellum assembly
H5404_RS19785	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5404_RS19795	COG1677	Flagellar hook-basal body complex protein FliE
H5404_RS19815	COG1516	flagellar protein fliS
H5404_RS19825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H5404_RS19830	COG1334	flagellar protein FlaG
H5404_RS19835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_RS19840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_RS19845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_RS19855	COG2837	iron assimilation
H5404_RS19880	COG1393	Belongs to the ArsC family
H5404_RS19885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5404_RS19900	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H5404_RS19905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5404_RS19910	COG2716	regulation of RNA biosynthetic process
H5404_RS19915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5404_RS19930	COG4783	chaperone-mediated protein folding
H5404_RS19935	COG1393	Belongs to the ArsC family
H5404_RS19955	COG2233	PERMEase
H5404_RS19960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H5404_RS19965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H5404_RS19970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5404_RS19975	COG0121	glutamine amidotransferase
H5404_RS19980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H5404_RS19985	COG1960	acyl-CoA dehydrogenase activity
H5404_RS19995	COG0456	acetyltransferase
H5404_RS20015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5404_RS20020	COG0328	RNA-DNA hybrid ribonuclease activity
H5404_RS20025	COG2226	methyltransferase
H5404_RS20030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5404_RS20035	COG1388	LysM domain
H5404_RS20035	COG0741	lytic transglycosylase activity
H5404_RS20045	COG3021	interspecies interaction between organisms
H5404_RS20050	COG0347	Belongs to the P(II) protein family
H5404_RS20060	COG0037	tRNA processing
H5404_RS20065	COG0825	malonyl-CoA metabolic process
H5404_RS20070	COG0587	DNA-directed DNA polymerase activity
H5404_RS20075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5404_RS20080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5404_RS20085	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5404_RS20090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5404_RS20095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5404_RS20100	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H5404_RS20110	COG0750	zinc metalloprotease
H5404_RS20115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H5404_RS20120	COG0575	Belongs to the CDS family
H5404_RS20125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H5404_RS20130	COG0233	cytoplasmic translational termination
H5404_RS20135	COG0528	UMP kinase activity
H5404_RS20140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H5404_RS20145	COG0052	Belongs to the universal ribosomal protein uS2 family
H5404_RS20150	COG0024	Methionine aminopeptidase
H5404_RS20155	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H5404_RS20165	COG0564	pseudouridine synthase activity
H5404_RS20170	COG3098	single-species biofilm formation
H5404_RS20195	COG1671	Belongs to the UPF0178 family
H5404_RS20200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H5404_RS20210	COG0254	rRNA binding
H5404_RS20215	COG1720	tRNA m6t6A37 methyltransferase activity
H5404_RS20220	COG0442	prolyl-tRNA aminoacylation
H5404_RS20240	COG0733	neurotransmitter:sodium symporter activity
H5404_RS20255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5404_RS20260	COG0514	ATP-dependent DNA helicase (RecQ)
H5404_RS20265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5404_RS20280	COG1477	protein flavinylation
H5404_RS20285	COG2871	sodium ion transport
H5404_RS20290	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5404_RS20295	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5404_RS20300	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5404_RS20305	COG1805	sodium ion transport
H5404_RS20310	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5404_RS20315	COG0271	Belongs to the BolA IbaG family
H5404_RS20320	COG2813	Specifically methylates the guanine in position
H5404_RS20325	COG3056	Lipoprotein
H5404_RS20345	COG1595	DNA-templated transcription, initiation
H5404_RS20365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H5404_RS20370	COG0693	protein deglycase activity
H5404_RS20375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5404_RS20380	COG3706	GGDEF domain
H5404_RS20385	COG2166	iron-sulfur cluster assembly
H5404_RS20390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H5404_RS20395	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H5404_RS20405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H5404_RS20405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5404_RS20415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5404_RS20420	COG1074	ATP-dependent DNA helicase activity
H5404_RS20425	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H5404_RS20445	COG3141	response to X-ray
H5404_RS20450	COG2171	N-acyltransferase activity
H5404_RS20455	COG0584	glycerophosphoryl diester phosphodiesterase
H5404_RS20460	COG2271	Major facilitator Superfamily
H5404_RS20465	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H5404_RS20470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H5404_RS20475	COG1349	DNA-binding transcription factor activity
H5404_RS20480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H5404_RS20485	COG0598	Magnesium transport protein CorA
H5404_RS20505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5404_RS20510	COG1609	Transcriptional regulator
H5404_RS20515	COG2176	DNA-directed DNA polymerase activity
H5404_RS20530	COG2017	converts alpha-aldose to the beta-anomer
H5404_RS20535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H5404_RS20545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5404_RS20550	COG1609	Transcriptional regulator
H5404_RS20555	COG3250	beta-galactosidase activity
H5404_RS20560	COG2731	YhcH YjgK YiaL family protein
H5404_RS20565	COG0531	amino acid
H5404_RS20570	COG0583	DNA-binding transcription factor activity
H5404_RS20630	COG4964	Belongs to the GSP D family
H5404_RS20655	COG2169	Transcriptional regulator
H5404_RS20660	COG1022	Amp-dependent synthetase and ligase
H5404_RS20670	COG0583	DNA-binding transcription factor activity
H5404_RS20675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5404_RS20680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H5404_RS20690	COG0560	Phosphoserine phosphatase
H5404_RS20700	COG0813	purine-nucleoside phosphorylase activity
H5404_RS20705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H5404_RS20710	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H5404_RS20715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H5404_RS20720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5404_RS20725	COG0084	hydrolase, TatD family'
H5404_RS20735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H5404_RS20755	COG3153	acetyltransferase
H5404_RS20760	COG3154	lipid carrier protein
H5404_RS20770	COG0826	peptidase U32
H5404_RS20775	COG0826	peptidase U32
H5404_RS20780	COG0534	Mate efflux family protein
H5404_RS20795	COG1185	polyribonucleotide nucleotidyltransferase activity
H5404_RS20800	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H5404_RS20805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H5404_RS20810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H5404_RS20815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H5404_RS20820	COG0195	Participates in both transcription termination and antitermination
H5404_RS20825	COG0779	Required for maturation of 30S ribosomal subunits
H5404_RS20840	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H5404_RS20845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5404_RS20850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5404_RS20855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5404_RS20860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H5404_RS20865	COG1534	Rna-binding protein
H5404_RS20870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5404_RS20875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H5404_RS20880	COG2027	D-alanyl-D-alanine carboxypeptidase
H5404_RS20890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5404_RS20895	COG0739	heme binding
H5404_RS20900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_RS20910	COG0316	Belongs to the HesB IscA family
H5404_RS20915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H5404_RS20920	COG0628	permease
H5404_RS20925	COG2813	Specifically methylates the guanine in position
H5404_RS20930	COG2205	protein histidine kinase activity
H5404_RS20930	COG2198	Histidine kinase
H5404_RS20930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_RS20930	COG0784	Response regulator, receiver
H5404_RS20935	COG0747	negative chemotaxis
H5404_RS20945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5404_RS20950	COG0444	Belongs to the ABC transporter superfamily
H5404_RS20955	COG4608	Belongs to the ABC transporter superfamily
H5404_RS20965	COG2971	BadF BadG BcrA BcrD
H5404_RS20980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5404_RS20985	COG3842	ATPase activity
H5404_RS20995	COG1840	ABC-type Fe3 transport system, periplasmic component
H5404_RS21000	COG0004	ammonium transporteR
H5404_RS21010	COG3112	Uncharacterised protein family (UPF0231)
H5404_RS21015	COG1049	propionate catabolic process, 2-methylcitrate cycle
H5404_RS21020	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5404_RS21025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5404_RS21030	COG1643	Atp-dependent helicase
H5404_RS21035	COG1489	DNA binding
H5404_RS21045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5404_RS21055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5404_RS21060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H5404_RS21065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H5404_RS21070	COG1560	Kdo2-lipid A biosynthetic process
H5404_RS21075	COG0842	Transport permease protein
H5404_RS21080	COG1131	(ABC) transporter
H5404_RS21085	COG0659	secondary active sulfate transmembrane transporter activity
H5404_RS21090	COG0288	reversible hydration of carbon dioxide
H5404_RS21105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5404_RS21110	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5404_RS21115	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H5404_RS21120	COG2186	Transcriptional regulator
H5404_RS21130	COG0157	Belongs to the NadC ModD family
H5404_RS21140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5404_RS21145	COG1459	type II secretion system
H5404_RS21155	COG0237	dephospho-CoA kinase activity
H5404_RS21160	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H5404_RS21165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H5404_RS21170	COG0335	large ribosomal subunit rRNA binding
H5404_RS21175	COG0336	Belongs to the RNA methyltransferase TrmD family
H5404_RS21180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H5404_RS21185	COG0228	four-way junction DNA binding
H5404_RS21190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5404_RS21195	COG4137	Cytochrome C assembly protein
H5404_RS21200	COG4536	flavin adenine dinucleotide binding
H5404_RS21205	COG1854	S-ribosylhomocysteine lyase activity
H5404_RS21215	COG2918	glutathione biosynthetic process
H5404_RS21220	COG0612	Peptidase, M16
H5404_RS21225	COG1238	metal cluster binding
H5404_RS21235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H5404_RS21240	COG0511	ligase activity, forming carbon-carbon bonds
H5404_RS21240	COG5016	pyruvate
H5404_RS21245	COG3630	sodium ion export across plasma membrane
H5404_RS21305	COG0527	aspartate kinase activity
H5404_RS21310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H5404_RS21315	COG2137	regulation of response to DNA damage stimulus
H5404_RS21320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H5404_RS21325	COG1546	Belongs to the CinA family
H5404_RS21330	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H5404_RS21335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H5404_RS21345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5404_RS21350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H5404_RS21355	COG0585	pseudouridine synthase activity
H5404_RS21360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H5404_RS21365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H5404_RS21370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H5404_RS21375	COG0148	phosphopyruvate hydratase activity
H5404_RS21380	COG0504	CTP synthase activity
H5404_RS21385	COG3956	TIGRFAM MazG family protein
H5404_RS21390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5404_RS21395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5404_RS21405	COG0736	holo-[acyl-carrier-protein] synthase activity
H5404_RS21410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H5404_RS21415	COG1381	Involved in DNA repair and RecF pathway recombination
H5404_RS21420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5404_RS21425	COG0571	ribonuclease III activity
H5404_RS21435	COG0481	GTPase activity
H5404_RS21440	COG3086	response to oxidative stress
H5404_RS21450	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H5404_RS21455	COG1595	DNA-templated transcription, initiation
H5404_RS21460	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H5404_RS21465	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H5404_RS21470	COG0354	folic acid binding
H5404_RS21485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5404_RS21490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5404_RS21495	COG3079	Belongs to the UPF0149 family
H5404_RS21500	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H5404_RS21510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5404_RS21515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H5404_RS21520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5404_RS21530	COG0583	DNA-binding transcription factor activity
H5404_RS21540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H5404_RS21545	COG0668	transmembrane transport
H5404_RS21550	COG0191	fructose-bisphosphate aldolase activity
H5404_RS21555	COG0126	phosphoglycerate kinase activity
H5404_RS21560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5404_RS21565	COG4771	TonB-dependent receptor
H5404_RS21570	COG0583	DNA-binding transcription factor activity
H5404_RS21575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5404_RS21580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H5404_RS21590	COG3091	SprT-like family
H5404_RS21595	COG2356	endonuclease I
H5404_RS21600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5404_RS21605	COG0189	ligase activity
H5404_RS21610	COG1678	Uncharacterized ACR, COG1678
H5404_RS21615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H5404_RS21630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H5404_RS21635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H5404_RS21640	COG0762	integral membrane protein
H5404_RS21645	COG1872	DUF167
H5404_RS21655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H5404_RS21660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5404_RS21665	COG2066	Belongs to the glutaminase family
H5404_RS21675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5404_RS21685	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H5404_RS21690	COG0741	lytic transglycosylase activity
H5404_RS21760	COG1012	belongs to the aldehyde dehydrogenase family
H5404_RS21805	COG3437	response regulator, receiver
H5404_RS21815	COG3394	polysaccharide catabolic process
H5404_RS21820	COG1486	melibiose metabolic process
H5404_RS21825	COG1447	Phosphotransferase system cellobiose-specific component IIA
H5404_RS21830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5404_RS21835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5404_RS21840	COG0726	polysaccharide deacetylase
H5404_RS21850	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_RS21865	COG0795	lipopolysaccharide-transporting ATPase activity
H5404_RS21870	COG0795	lipopolysaccharide-transporting ATPase activity
H5404_RS21875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5404_RS21880	COG2927	DNA polymerase III (CHI subunit)
H5404_RS21885	COG0525	valine-tRNA ligase activity
H5404_RS21910	COG2235	arginine
H5404_RS21915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H5404_RS21925	COG0540	Belongs to the ATCase OTCase family
H5404_RS21930	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H5404_RS21935	COG0251	oxidation-reduction process
H5404_RS21940	COG0204	Acyl-transferase
H5404_RS21945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5404_RS21950	COG5007	Belongs to the BolA IbaG family
H5404_RS21960	COG2854	intermembrane phospholipid transfer
H5404_RS21965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5404_RS21970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H5404_RS21975	COG1127	ABC transporter
H5404_RS21985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H5404_RS21985	COG0517	IMP dehydrogenase activity
H5404_RS21995	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H5404_RS22000	COG1137	ATPase activity
H5404_RS22010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H5404_RS22015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_RS22020	COG1660	Displays ATPase and GTPase activities
H5404_RS22025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_RS22030	COG2239	Acts as a magnesium transporter
H5404_RS22035	COG0312	modulator of DNA gyrase
H5404_RS22040	COG3028	Belongs to the UPF0307 family
H5404_RS22045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5404_RS22050	COG0564	pseudouridine synthase activity
H5404_RS22060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5404_RS22065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H5404_RS22070	COG0312	modulator of DNA gyrase
H5404_RS22075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5404_RS22080	COG3164	Protein of unknown function
H5404_RS22090	COG0424	maF-like protein
H5404_RS22095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H5404_RS22100	COG1792	Involved in formation and maintenance of cell shape
H5404_RS22105	COG1077	Cell shape determining protein MreB Mrl
H5404_RS22140	COG2165	general secretion pathway protein
H5404_RS22150	COG1459	type II secretion system
H5404_RS22155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5404_RS22165	COG3409	Peptidoglycan-binding domain 1 protein
H5404_RS22165	COG3267	Type II secretory pathway component ExeA
H5404_RS22190	COG2200	EAL domain
H5404_RS22190	COG2199	diguanylate cyclase activity
H5404_RS22195	COG0629	single-stranded DNA binding
H5404_RS22210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H5404_RS22220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5404_RS22225	COG0527	aspartate kinase activity
H5404_RS22230	COG1410	methionine synthase
H5404_RS22230	COG0646	methionine synthase
H5404_RS22245	COG3335	DDE superfamily endonuclease
H5404_RS22330	COG0175	sulfate reduction
H5404_RS22335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5404_RS22340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5404_RS22360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5404_RS22475	COG0735	belongs to the Fur family
H5404_RS22485	COG0166	Belongs to the GPI family
H5404_RS22490	COG0432	Pfam Uncharacterised protein family UPF0047
H5404_RS22500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5404_RS22515	COG0359	binds to the 23S rRNA
H5404_RS22525	COG2965	DNA replication, synthesis of RNA primer
H5404_RS22530	COG0360	Binds together with S18 to 16S ribosomal RNA
H5404_RS22535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5404_RS22540	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H5404_RS22550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H5404_RS22555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H5404_RS22585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H5404_RS22595	COG0678	peroxiredoxin activity
H5404_RS22595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5404_RS22605	COG0165	Argininosuccinate lyase
H5404_RS22605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H5404_RS22610	COG0137	argininosuccinate synthase activity
H5404_RS22615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5404_RS22620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H5404_RS22625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5404_RS22630	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H5404_RS22640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H5404_RS22645	COG0460	homoserine dehydrogenase
H5404_RS22645	COG0527	aspartate kinase activity
H5404_RS22650	COG0626	cystathionine gamma-synthase activity
H5404_RS22660	COG0281	malic enzyme
H5404_RS22670	COG2906	2 iron, 2 sulfur cluster binding
H5404_RS22675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H5404_RS22680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5404_RS22685	COG0049	tRNA binding
H5404_RS22695	COG2168	tRNA wobble position uridine thiolation
H5404_RS22700	COG2923	Belongs to the DsrF TusC family
H5404_RS22705	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H5404_RS22710	COG2964	Protein conserved in bacteria
H5404_RS22715	COG0545	Peptidyl-prolyl cis-trans isomerase
H5404_RS22725	COG2900	Belongs to the SlyX family
H5404_RS22730	COG1446	asparaginase
H5404_RS22735	COG1047	Peptidyl-prolyl cis-trans
H5404_RS22750	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5404_RS22755	COG0488	(ABC) transporter
H5404_RS22765	COG0429	hydrolase of the alpha beta-hydrolase fold
H5404_RS22770	COG3089	Belongs to the UPF0270 family
H5404_RS22775	COG3954	Phosphoribulokinase
H5404_RS22780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5404_RS22790	COG1012	belongs to the aldehyde dehydrogenase family
H5404_RS22800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5404_RS22820	COG0180	Tryptophanyl-tRNA synthetase
H5404_RS22825	COG0546	phosphoglycolate phosphatase activity
H5404_RS22830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5404_RS22835	COG0557	exoribonuclease II activity
H5404_RS22840	COG1959	2 iron, 2 sulfur cluster binding
H5404_RS22845	COG1017	nitric oxide dioxygenase activity
H5404_RS22845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5404_RS22850	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H5404_RS22855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5404_RS22860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H5404_RS22865	COG0330	HflC and HflK could
H5404_RS22870	COG0330	HflC and HflK could
H5404_RS22875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5404_RS22885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H5404_RS22890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H5404_RS22895	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5404_RS22900	COG0802	atpase or kinase
H5404_RS22905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5404_RS22975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H5404_RS22980	COG1162	GTPase activity
H5404_RS22985	COG0688	phosphatidylethanolamine metabolic process
H5404_RS22990	COG0471	metal ion transport
H5404_RS23005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H5404_RS23010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5404_RS23015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H5404_RS23020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H5404_RS23025	COG1045	serine acetyltransferase
H5404_RS23030	COG4942	peptidase
H5404_RS23050	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H5404_RS23055	COG1053	succinate dehydrogenase
H5404_RS23060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5404_RS23065	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H5404_RS23070	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H5404_RS23080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5404_RS23085	COG1509	lysine 2,3-aminomutase activity
H5404_RS23090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5404_RS23105	COG0459	protein refolding
H5404_RS23115	COG0534	Mate efflux family protein
H5404_RS23120	COG0205	6-phosphofructokinase activity
H5404_RS23130	COG3678	ATP-independent chaperone mediated protein folding
H5404_RS23135	COG0745	RESPONSE REGULATOR receiver
H5404_RS23140	COG2205	protein histidine kinase activity
H5404_RS23150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5404_RS23155	COG3030	protein affecting phage T7 exclusion by the F plasmid
H5404_RS23160	COG1027	Aspartate ammonia-lyase
H5404_RS23165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H5404_RS23170	COG4232	protein-disulfide reductase activity
H5404_RS23180	COG3263	regulation of cellular component size
H5404_RS23190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5404_RS23210	COG0784	Response regulator, receiver
H5404_RS23210	COG2198	Histidine kinase
H5404_RS23210	COG2205	protein histidine kinase activity
H5404_RS23215	COG2814	Major facilitator Superfamily
H5404_RS23230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5404_RS23235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H5404_RS23240	COG0511	ligase activity, forming carbon-carbon bonds
H5404_RS23245	COG0439	Biotin carboxylase
H5404_RS23250	COG2264	protein methyltransferase activity
H5404_RS23255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5404_RS23260	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H5404_RS23265	COG2814	Major facilitator Superfamily
H5404_RS23275	COG3706	GGDEF domain
H5404_RS23280	COG3335	DDE superfamily endonuclease
H5404_RS23340	COG1982	Orn Lys Arg decarboxylase major
H5404_RS23345	COG0531	amino acid
H5404_RS23350	COG3710	Transcriptional regulator
H5404_RS23355	COG0789	Transcriptional regulator
H5404_RS23360	COG0138	bifunctional purine biosynthesis protein purh
H5404_RS23365	COG0151	Belongs to the GarS family
H5404_RS23380	COG1253	flavin adenine dinucleotide binding
H5404_RS23390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5404_RS23395	COG1573	uracil-dna glycosylase
H5404_RS23400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H5404_RS23415	COG2816	NAD+ diphosphatase activity
H5404_RS23420	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H5404_RS23425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H5404_RS23430	COG0085	RNA polymerase activity
H5404_RS23435	COG0222	ribosome binding
H5404_RS23440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H5404_RS23445	COG0081	regulation of translation
H5404_RS23450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H5404_RS23455	COG0250	Participates in transcription elongation, termination and antitermination
H5404_RS23460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H5404_RS23465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H5404_RS23500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H5404_RS23510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5404_RS23545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5404_RS23555	COG4206	TonB-dependent receptor
H5404_RS23560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5404_RS23575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5404_RS23580	COG0534	Mate efflux family protein
H5404_RS23585	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H5404_RS23590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5404_RS23595	COG2937	Belongs to the GPAT DAPAT family
H5404_RS23600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H5404_RS23605	COG3161	chorismate lyase activity
H5404_RS23610	COG1580	Controls the rotational direction of flagella during chemotaxis
H5404_RS23615	COG0705	Rhomboid family
H5404_RS23620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5404_RS23630	COG2177	Part of the ABC transporter FtsEX involved in
H5404_RS23635	COG2884	Cell division ATP-binding protein ftsE
H5404_RS23640	COG0552	protein localization to endoplasmic reticulum
H5404_RS23645	COG0742	ribosomal rna small subunit methyltransferase
H5404_RS23655	COG2095	MarC family integral membrane protein
H5404_RS23705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5404_RS23710	COG0640	Transcriptional regulator
H5404_RS23715	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H5404_RS23720	COG1280	lysine exporter protein (LysE YggA)
H5404_RS23725	COG2267	carboxylic ester hydrolase activity
H5404_RS23730	COG0561	phosphatase activity
H5404_RS23745	COG3148	PFAM DTW domain containing protein
H5404_RS23750	COG3287	FIST C domain
H5404_RS23750	COG2199	diguanylate cyclase activity
H5404_RS23750	COG2200	EAL domain
H5404_RS23755	COG1011	Hydrolase
H5404_RS23760	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H5404_RS23770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H5404_RS23775	COG0019	diaminopimelate decarboxylase activity
H5404_RS23785	COG1965	Belongs to the frataxin family
H5404_RS23790	COG3072	Adenylate cyclase
H5404_RS23795	COG0181	hydroxymethylbilane synthase activity
H5404_RS23800	COG1587	Uroporphyrinogen-III synthase
H5404_RS23805	COG2959	enzyme of heme biosynthesis
H5404_RS23810	COG3071	HemY protein
H5404_RS23855	COG0633	Ferredoxin
H5404_RS23860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H5404_RS23875	COG3118	belongs to the thioredoxin family
H5404_RS23880	COG0513	Belongs to the DEAD box helicase family
H5404_RS23885	COG0248	Ppx GppA phosphatase
H5404_RS23890	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H5404_RS23900	COG0514	ATP-dependent DNA helicase (RecQ)
H5404_RS23905	COG2962	Rard protein
H5404_RS23915	COG1280	lysine exporter protein (LysE YggA)
H5404_RS23920	COG0405	Gamma-glutamyltransferase
H5404_RS23925	COG0210	DNA helicase
H5404_RS23935	COG3220	belongs to the UPF0276 family
H5404_RS23965	COG0006	proline dipeptidase activity
H5404_RS23965	COG0006	proline dipeptidase activity
H5404_RS23975	COG2022	thiamine diphosphate biosynthetic process
H5404_RS23980	COG2104	thiamine diphosphate biosynthetic process
H5404_RS23985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5404_RS23990	COG0352	thiamine-phosphate diphosphorylase activity
H5404_RS23995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H5404_RS24000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H5404_RS24015	COG3335	DDE superfamily endonuclease
H5404_RS24055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H5404_RS24065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H5404_RS24070	COG0408	coproporphyrinogen oxidase activity
H5404_RS24075	COG0009	L-threonylcarbamoyladenylate synthase
H5404_RS24080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H5404_RS24085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H5404_RS24090	COG0551	DNA topoisomerase type I activity
H5404_RS24095	COG2922	Belongs to the Smg family
H5404_RS24100	COG0758	DNA mediated transformation
H5404_RS24110	COG0242	peptide deformylase activity
H5404_RS24115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5404_RS24120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5404_RS24120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5404_RS24125	COG0569	domain protein
H5404_RS24130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5404_RS24140	COG1272	protein, Hemolysin III
H5404_RS24145	COG4326	sporulation control protein
H5404_RS24155	COG3084	Protein conserved in bacteria
H5404_RS24165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5404_RS24170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5404_RS24175	COG0204	Acyl-transferase
H5404_RS24215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5404_RS24250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H5404_RS24315	COG3978	acetolactate synthase activity
H5404_RS24320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5404_RS24325	COG0129	dihydroxy-acid dehydratase activity
H5404_RS24335	COG0583	DNA-binding transcription factor activity
H5404_RS24340	COG2814	Major facilitator Superfamily
H5404_RS24345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_RS24350	COG0765	amino acid transport
H5404_RS24355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H5404_RS24360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H5404_RS24365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H5404_RS24370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H5404_RS24375	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H5404_RS24380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H5404_RS24395	COG0356	it plays a direct role in the translocation of protons across the membrane
H5404_RS24400	COG3312	ion transport
H5404_RS24405	COG1475	DNA binding
H5404_RS24410	COG1192	Involved in chromosome partitioning
H5404_RS24415	COG0357	Ribosomal RNA small subunit methyltransferase G
H5404_RS24420	COG0445	tRNA wobble uridine modification
H5404_RS24425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5404_RS24430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H5404_RS24435	COG0706	membrane insertase activity
H5404_RS24445	COG0594	ribonuclease P activity
H5404_RS24455	COG1126	abc transporter atp-binding protein
H5404_RS24510	COG3093	addiction module antidote protein HigA
H5404_RS24515	COG3549	Plasmid maintenance system killer
H5404_RS24535	COG2067	long-chain fatty acid transport protein
H5404_RS24590	COG2003	Belongs to the UPF0758 family
H5404_RS24725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5404_RS24755	COG4115	mRNA cleavage
H5404_RS24760	COG2161	toxin-antitoxin pair type II binding
H5404_RS24775	COG2885	chlorophyll binding
H5404_RS24775	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H5404_RS24780	COG5492	domain, Protein
H5404_RS24780	COG4932	domain protein
H5404_RS24795	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H5404_RS24925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5404_RS25025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5404_RS25230	COG0740	serine-type endopeptidase activity
H5404_RS25235	COG4695	Portal protein
H5404_RS25240	COG4626	Terminase
H5404_RS25240	COG1802	Transcriptional regulator
H5404_RS25365	COG1192	Involved in chromosome partitioning
H5404_RS25425	COG1192	Involved in chromosome partitioning
H5404_RS25495	COG2885	chlorophyll binding
H5404_RS25635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5404_RS25750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5404_RS25775	COG2948	multi-organism process
H5404_RS25785	COG3504	Conjugal transfer protein
H5404_RS25805	COG4962	Type ii secretion system protein e
H5404_RS25815	COG3451	type IV secretory pathway VirB4
H5404_RS25820	COG5268	conjugation
H5404_RS25840	COG1396	sequence-specific DNA binding