locus-tag	class	description
VPUCM_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VPUCM_RS00010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VPUCM_RS00015	COG0706	membrane insertase activity
VPUCM_RS00020	COG0594	ribonuclease P activity
VPUCM_RS00030	COG1126	abc transporter atp-binding protein
VPUCM_RS00045	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VPUCM_RS00050	COG0592	DNA-directed DNA polymerase activity
VPUCM_RS00055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VPUCM_RS00060	COG0187	DNA topoisomerase II activity
VPUCM_RS00075	COG0071	Belongs to the small heat shock protein (HSP20) family
VPUCM_RS00080	COG3977	Valine--pyruvate aminotransferase
VPUCM_RS00085	COG0366	Alpha amylase catalytic
VPUCM_RS00090	COG0751	glycine-tRNA ligase activity
VPUCM_RS00095	COG0752	glycyl-tRNA synthetase alpha subunit
VPUCM_RS00100	COG2119	membrane
VPUCM_RS00110	COG0425	Belongs to the sulfur carrier protein TusA family
VPUCM_RS00125	COG0604	alcohol dehydrogenase
VPUCM_RS00130	COG0183	Belongs to the thiolase family
VPUCM_RS00135	COG1024	Enoyl-CoA hydratase
VPUCM_RS00135	COG1250	3-hydroxyacyl-CoA dehydrogenase
VPUCM_RS00140	COG1739	Uncharacterized protein family UPF0029
VPUCM_RS00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPUCM_RS00185	COG0583	DNA-binding transcription factor activity
VPUCM_RS00190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VPUCM_RS00195	COG2960	long-chain fatty acid transporting porin activity
VPUCM_RS00200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPUCM_RS00205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_RS00260	COG4172	Belongs to the ABC transporter superfamily
VPUCM_RS00265	COG0747	negative chemotaxis
VPUCM_RS00270	COG0601	transmembrane transport
VPUCM_RS00275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPUCM_RS00310	COG1609	Transcriptional regulator
VPUCM_RS00315	COG0583	DNA-binding transcription factor activity
VPUCM_RS00330	COG0129	dihydroxy-acid dehydratase activity
VPUCM_RS00335	COG3265	gluconokinase activity
VPUCM_RS00340	COG2610	gluconate transmembrane transporter activity
VPUCM_RS00345	COG0800	Aldolase
VPUCM_RS00350	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VPUCM_RS00355	COG0583	DNA-binding transcription factor activity
VPUCM_RS00360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPUCM_RS00365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VPUCM_RS00370	COG0339	signal peptide processing
VPUCM_RS00375	COG1522	sequence-specific DNA binding
VPUCM_RS00385	COG0742	ribosomal rna small subunit methyltransferase
VPUCM_RS00400	COG0589	response to stress
VPUCM_RS00405	COG1528	Iron-storage protein
VPUCM_RS00415	COG2081	HI0933 family
VPUCM_RS00425	COG2823	Periplasmic or secreted lipoprotein
VPUCM_RS00445	COG1597	lipid kinase activity
VPUCM_RS00475	COG0628	permease
VPUCM_RS00490	COG1322	Protein conserved in bacteria
VPUCM_RS00495	COG2226	methyltransferase
VPUCM_RS00500	COG3165	ubiquinone biosynthetic process from chorismate
VPUCM_RS00505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VPUCM_RS00510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VPUCM_RS00515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VPUCM_RS00520	COG0805	protein transport
VPUCM_RS00525	COG0084	hydrolase, TatD family'
VPUCM_RS00540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPUCM_RS00540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPUCM_RS00545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VPUCM_RS00580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VPUCM_RS00590	COG2204	response regulator
VPUCM_RS00595	COG3852	Histidine kinase
VPUCM_RS00605	COG0174	glutamine synthetase
VPUCM_RS00610	COG1217	gtp-binding protein TYPA
VPUCM_RS00625	COG1295	ribonuclease BN
VPUCM_RS00630	COG1490	D-aminoacyl-tRNA deacylase activity
VPUCM_RS00635	COG0456	acetyltransferase
VPUCM_RS00645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VPUCM_RS00650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VPUCM_RS00655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VPUCM_RS00660	COG3031	protein transport across the cell outer membrane
VPUCM_RS00670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPUCM_RS00675	COG1459	type II secretion system
VPUCM_RS00680	COG2165	general secretion pathway protein
VPUCM_RS00685	COG2165	general secretion pathway protein
VPUCM_RS00690	COG2165	general secretion pathway protein
VPUCM_RS00695	COG4795	General secretion pathway protein
VPUCM_RS00700	COG3156	type II secretion system protein K
VPUCM_RS00705	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VPUCM_RS00710	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VPUCM_RS00720	COG1218	3'(2'),5'-bisphosphate nucleotidase
VPUCM_RS00725	COG0494	nUDIX hydrolase
VPUCM_RS00730	COG0316	Belongs to the HesB IscA family
VPUCM_RS00730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VPUCM_RS00735	COG1040	competence protein
VPUCM_RS00740	COG0596	Alpha beta hydrolase
VPUCM_RS00750	COG2183	response to ionizing radiation
VPUCM_RS00760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPUCM_RS00780	COG2233	PERMEase
VPUCM_RS00790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VPUCM_RS00795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPUCM_RS00800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VPUCM_RS00805	COG1758	RNA polymerase activity
VPUCM_RS00810	COG0194	GDP metabolic process
VPUCM_RS00825	COG0848	biopolymer transport protein
VPUCM_RS00830	COG0811	peptide transport
VPUCM_RS00850	COG4174	ABC transporter (Permease)
VPUCM_RS00855	COG4239	(ABC) transporter, permease
VPUCM_RS00860	COG0747	negative chemotaxis
VPUCM_RS00865	COG0444	Belongs to the ABC transporter superfamily
VPUCM_RS00870	COG4608	Belongs to the ABC transporter superfamily
VPUCM_RS00900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_RS00910	COG1561	YicC-like family, N-terminal region
VPUCM_RS00915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VPUCM_RS00920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VPUCM_RS00925	COG1560	Kdo2-lipid A biosynthetic process
VPUCM_RS00930	COG1309	transcriptional regulator
VPUCM_RS00935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VPUCM_RS00940	COG0840	transmembrane signaling receptor activity
VPUCM_RS00945	COG2003	Belongs to the UPF0758 family
VPUCM_RS00950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VPUCM_RS00965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VPUCM_RS00975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VPUCM_RS00985	COG0463	Glycosyl transferase, family 2
VPUCM_RS00990	COG0859	PFAM glycosyl transferase family 9
VPUCM_RS00995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VPUCM_RS01000	COG3642	lipopolysaccharide core region biosynthetic process
VPUCM_RS01020	COG1045	serine acetyltransferase
VPUCM_RS01025	COG1086	Polysaccharide biosynthesis protein
VPUCM_RS01030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VPUCM_RS01035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VPUCM_RS01040	COG2089	acid synthase
VPUCM_RS01050	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VPUCM_RS01055	COG1083	cytidylyl-transferase
VPUCM_RS01065	COG1519	Transferase
VPUCM_RS01070	COG0859	PFAM glycosyl transferase family 9
VPUCM_RS01075	COG1560	Kdo2-lipid A biosynthetic process
VPUCM_RS01085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPUCM_RS01110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VPUCM_RS01115	COG2895	sulfate adenylyltransferase (ATP) activity
VPUCM_RS01125	COG0529	Catalyzes the synthesis of activated sulfate
VPUCM_RS01130	COG0175	sulfate reduction
VPUCM_RS01145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPUCM_RS01150	COG1459	type II secretion system
VPUCM_RS01170	COG3156	type II secretion system protein K
VPUCM_RS01200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VPUCM_RS01245	COG1088	dTDP-glucose 4,6-dehydratase activity
VPUCM_RS01270	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VPUCM_RS01275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VPUCM_RS01280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VPUCM_RS01280	COG0517	IMP dehydrogenase activity
VPUCM_RS01285	COG0438	transferase activity, transferring glycosyl groups
VPUCM_RS01285	COG1216	Glycosyl transferase, family 2
VPUCM_RS01315	COG3273	potassium ion transport
VPUCM_RS01315	COG0471	metal ion transport
VPUCM_RS01325	COG0438	transferase activity, transferring glycosyl groups
VPUCM_RS01325	COG1216	Glycosyl transferase, family 2
VPUCM_RS01350	COG0149	triose-phosphate isomerase activity
VPUCM_RS01375	COG1494	fructose-1,6-bisphosphatase
VPUCM_RS01380	COG3074	FtsZ-dependent cytokinesis
VPUCM_RS01385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VPUCM_RS01390	COG1575	Belongs to the MenA family. Type 1 subfamily
VPUCM_RS01395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VPUCM_RS01400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VPUCM_RS01410	COG1609	Transcriptional regulator
VPUCM_RS01415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VPUCM_RS01420	COG0254	rRNA binding
VPUCM_RS01430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VPUCM_RS01435	COG0088	Forms part of the polypeptide exit tunnel
VPUCM_RS01445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VPUCM_RS01450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VPUCM_RS01455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VPUCM_RS01460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VPUCM_RS01470	COG0255	Belongs to the universal ribosomal protein uL29 family
VPUCM_RS01475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VPUCM_RS01480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VPUCM_RS01485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VPUCM_RS01490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VPUCM_RS01495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VPUCM_RS01500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VPUCM_RS01505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VPUCM_RS01520	COG1841	ribosomal large subunit assembly
VPUCM_RS01525	COG0200	Binds to the 23S rRNA
VPUCM_RS01530	COG0201	protein transport
VPUCM_RS01535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VPUCM_RS01540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VPUCM_RS01545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VPUCM_RS01555	COG0202	RNA polymerase activity
VPUCM_RS01560	COG0203	ribosomal protein L17
VPUCM_RS01570	COG0545	Peptidyl-prolyl cis-trans isomerase
VPUCM_RS01580	COG2153	protein acetylation
VPUCM_RS01585	COG0513	Belongs to the DEAD box helicase family
VPUCM_RS01595	COG0737	Belongs to the 5'-nucleotidase family
VPUCM_RS01600	COG1648	precorrin-2 dehydrogenase activity
VPUCM_RS01600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VPUCM_RS01605	COG0175	sulfate reduction
VPUCM_RS01610	COG2895	sulfate adenylyltransferase (ATP) activity
VPUCM_RS01615	COG3273	potassium ion transport
VPUCM_RS01615	COG0471	metal ion transport
VPUCM_RS01620	COG0529	Catalyzes the synthesis of activated sulfate
VPUCM_RS01640	COG4181	ATPase activity
VPUCM_RS01655	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VPUCM_RS01665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPUCM_RS01670	COG0729	surface antigen
VPUCM_RS01675	COG2911	Protein conserved in bacteria
VPUCM_RS01680	COG2105	PFAM AIG2 family protein
VPUCM_RS01690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VPUCM_RS01695	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VPUCM_RS01700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VPUCM_RS01705	COG0163	prenyltransferase activity
VPUCM_RS01710	COG4143	(ABC) transporter
VPUCM_RS01715	COG1178	ABC-type Fe3 transport system permease component
VPUCM_RS01720	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VPUCM_RS01735	COG2358	TRAP transporter, solute receptor (TAXI family
VPUCM_RS01745	COG0039	L-malate dehydrogenase activity
VPUCM_RS01755	COG0142	geranyltranstransferase activity
VPUCM_RS01760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VPUCM_RS01770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VPUCM_RS01775	COG2966	Psort location CytoplasmicMembrane, score
VPUCM_RS01790	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VPUCM_RS01795	COG2967	ApaG domain
VPUCM_RS01800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VPUCM_RS01805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VPUCM_RS01810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VPUCM_RS01815	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VPUCM_RS01820	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VPUCM_RS01830	COG0066	3-isopropylmalate dehydratase activity
VPUCM_RS01835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VPUCM_RS01840	COG0473	3-isopropylmalate dehydrogenase activity
VPUCM_RS01845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VPUCM_RS01865	COG0583	DNA-binding transcription factor activity
VPUCM_RS01870	COG1022	Amp-dependent synthetase and ligase
VPUCM_RS01875	COG0028	Belongs to the TPP enzyme family
VPUCM_RS01880	COG0440	acetolactate synthase activity
VPUCM_RS01895	COG0469	pyruvate kinase activity
VPUCM_RS01900	COG1349	DNA-binding transcription factor activity
VPUCM_RS01905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VPUCM_RS01920	COG5002	protein histidine kinase activity
VPUCM_RS01930	COG2376	Dihydroxyacetone kinase
VPUCM_RS01935	COG1461	Dihydroxyacetone kinase
VPUCM_RS01950	COG3722	fumarate hydratase activity
VPUCM_RS01955	COG0246	Mannitol dehydrogenase
VPUCM_RS01960	COG2213	PTS system mannitol-specific
VPUCM_RS01960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_RS01990	COG1464	Belongs to the NlpA lipoprotein family
VPUCM_RS02005	COG0358	DNA primase activity
VPUCM_RS02010	COG1610	YqeY-like protein
VPUCM_RS02015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VPUCM_RS02020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VPUCM_RS02025	COG0596	Alpha beta hydrolase
VPUCM_RS02030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VPUCM_RS02035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VPUCM_RS02040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VPUCM_RS02045	COG1968	undecaprenyl-diphosphatase activity
VPUCM_RS02050	COG0617	tRNA 3'-terminal CCA addition
VPUCM_RS02055	COG3267	Type II secretory pathway component ExeA
VPUCM_RS02055	COG3409	Peptidoglycan-binding domain 1 protein
VPUCM_RS02065	COG4991	sh3 domain protein
VPUCM_RS02070	COG0306	phosphate transporter
VPUCM_RS02075	COG1392	Phosphate transport regulator
VPUCM_RS02080	COG3025	triphosphatase activity
VPUCM_RS02095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VPUCM_RS02100	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VPUCM_RS02100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VPUCM_RS02105	COG1538	Outer membrane efflux protein
VPUCM_RS02110	COG0494	nUDIX hydrolase
VPUCM_RS02115	COG3151	Protein conserved in bacteria
VPUCM_RS02125	COG3150	esterase
VPUCM_RS02135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VPUCM_RS02140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VPUCM_RS02150	COG3105	Protein conserved in bacteria
VPUCM_RS02155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VPUCM_RS02160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VPUCM_RS02165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VPUCM_RS02170	COG0723	plastoquinol--plastocyanin reductase activity
VPUCM_RS02175	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VPUCM_RS02180	COG2857	Cytochrome c1
VPUCM_RS02185	COG0625	glutathione transferase activity
VPUCM_RS02190	COG2969	positive regulation of protein catabolic process
VPUCM_RS02195	COG2823	Periplasmic or secreted lipoprotein
VPUCM_RS02200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VPUCM_RS02205	COG0792	nuclease activity
VPUCM_RS02215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VPUCM_RS02220	COG0275	rRNA processing
VPUCM_RS02225	COG3116	cell division
VPUCM_RS02230	COG0768	penicillin binding
VPUCM_RS02235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VPUCM_RS02240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VPUCM_RS02245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VPUCM_RS02250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VPUCM_RS02255	COG0772	Belongs to the SEDS family
VPUCM_RS02260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VPUCM_RS02265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VPUCM_RS02270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VPUCM_RS02275	COG0849	cell division
VPUCM_RS02280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VPUCM_RS02285	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VPUCM_RS02295	COG0653	protein targeting
VPUCM_RS02300	COG0494	nUDIX hydrolase
VPUCM_RS02305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VPUCM_RS02310	COG0505	Belongs to the CarA family
VPUCM_RS02315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VPUCM_RS02330	COG0730	response to heat
VPUCM_RS02345	COG0583	DNA-binding transcription factor activity
VPUCM_RS02350	COG2860	membrane
VPUCM_RS02355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VPUCM_RS02365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VPUCM_RS02375	COG0493	'glutamate synthase
VPUCM_RS02380	COG0067	glutamate synthase
VPUCM_RS02380	COG0069	glutamate synthase activity
VPUCM_RS02380	COG0070	glutamate synthase
VPUCM_RS02390	COG0067	glutamate synthase
VPUCM_RS02390	COG0070	glutamate synthase
VPUCM_RS02390	COG0069	glutamate synthase activity
VPUCM_RS02395	COG1242	4 iron, 4 sulfur cluster binding
VPUCM_RS02400	COG2203	Gaf domain
VPUCM_RS02400	COG5001	Diguanylate cyclase
VPUCM_RS02400	COG4251	negative regulation of phosphorylation
VPUCM_RS02400	COG3706	GGDEF domain
VPUCM_RS02405	COG0784	Response regulator, receiver
VPUCM_RS02405	COG2198	Histidine kinase
VPUCM_RS02405	COG5002	protein histidine kinase activity
VPUCM_RS02415	COG0745	RESPONSE REGULATOR receiver
VPUCM_RS02425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VPUCM_RS02440	COG0083	homoserine kinase activity
VPUCM_RS02445	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VPUCM_RS02450	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VPUCM_RS02455	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VPUCM_RS02460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VPUCM_RS02475	COG1115	amino acid carrier protein
VPUCM_RS02480	COG3022	response to hydroperoxide
VPUCM_RS02485	COG0513	Belongs to the DEAD box helicase family
VPUCM_RS02490	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VPUCM_RS02500	COG0716	FMN binding
VPUCM_RS02505	COG4974	Belongs to the 'phage' integrase family
VPUCM_RS02510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPUCM_RS02515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VPUCM_RS02520	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VPUCM_RS02525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VPUCM_RS02530	COG2204	response regulator
VPUCM_RS02540	COG0667	Aldo Keto reductase
VPUCM_RS02550	COG3066	DNA modification
VPUCM_RS02555	COG0494	nUDIX hydrolase
VPUCM_RS02565	COG0730	response to heat
VPUCM_RS02570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VPUCM_RS02575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VPUCM_RS02585	COG1283	sodium-dependent phosphate transmembrane transporter activity
VPUCM_RS02590	COG0583	DNA-binding transcription factor activity
VPUCM_RS02595	COG0640	Transcriptional regulator
VPUCM_RS02600	COG0268	Binds directly to 16S ribosomal RNA
VPUCM_RS02605	COG0728	peptidoglycan biosynthetic process
VPUCM_RS02610	COG0196	riboflavin kinase activity
VPUCM_RS02615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VPUCM_RS02620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VPUCM_RS02625	COG1047	Peptidyl-prolyl cis-trans
VPUCM_RS02630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VPUCM_RS02635	COG3279	Response regulator of the LytR AlgR family
VPUCM_RS02640	COG3275	phosphorelay sensor kinase activity
VPUCM_RS02645	COG1966	Carbon starvation protein
VPUCM_RS02660	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VPUCM_RS02665	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VPUCM_RS02670	COG1472	Belongs to the glycosyl hydrolase 3 family
VPUCM_RS02675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VPUCM_RS02680	COG0287	Prephenate dehydrogenase
VPUCM_RS02680	COG1605	Chorismate mutase
VPUCM_RS02685	COG0739	heme binding
VPUCM_RS02700	COG0488	(ABC) transporter
VPUCM_RS02710	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VPUCM_RS02715	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VPUCM_RS02720	COG1605	Chorismate mutase
VPUCM_RS02720	COG0077	Prephenate dehydratase
VPUCM_RS02725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VPUCM_RS02730	COG0741	lytic transglycosylase activity
VPUCM_RS02735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPUCM_RS02740	COG0564	pseudouridine synthase activity
VPUCM_RS02750	COG0542	response to heat
VPUCM_RS02805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VPUCM_RS02810	COG0826	peptidase U32
VPUCM_RS02815	COG2974	May be involved in recombination
VPUCM_RS02820	COG0745	RESPONSE REGULATOR receiver
VPUCM_RS02825	COG5002	protein histidine kinase activity
VPUCM_RS02835	COG0248	Ppx GppA phosphatase
VPUCM_RS02840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VPUCM_RS02850	COG0581	inorganic phosphate transmembrane transporter activity
VPUCM_RS02855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VPUCM_RS02860	COG0704	Plays a role in the regulation of phosphate uptake
VPUCM_RS02870	COG3142	Participates in the control of copper homeostasis
VPUCM_RS02875	COG0450	alkyl hydroperoxide reductase
VPUCM_RS02880	COG0583	DNA-binding transcription factor activity
VPUCM_RS02885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VPUCM_RS02895	COG0517	IMP dehydrogenase activity
VPUCM_RS02905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VPUCM_RS02910	COG0343	queuine tRNA-ribosyltransferase activity
VPUCM_RS02915	COG1862	Preprotein translocase
VPUCM_RS02920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPUCM_RS02925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPUCM_RS02930	COG0483	inositol monophosphate 1-phosphatase activity
VPUCM_RS02945	COG1104	cysteine desulfurase activity
VPUCM_RS02950	COG0822	iron-sulfur transferase activity
VPUCM_RS02960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VPUCM_RS02965	COG0443	Heat shock 70 kDa protein
VPUCM_RS02970	COG0633	Ferredoxin
VPUCM_RS02975	COG2975	iron-sulfur cluster assembly
VPUCM_RS02980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VPUCM_RS02985	COG0105	UTP biosynthetic process
VPUCM_RS02990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VPUCM_RS03000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VPUCM_RS03005	COG0124	histidyl-tRNA synthetase
VPUCM_RS03010	COG2976	Protein conserved in bacteria
VPUCM_RS03015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPUCM_RS03020	COG1160	GTP binding
VPUCM_RS03035	COG1570	exodeoxyribonuclease VII activity
VPUCM_RS03040	COG0516	GMP reductase activity
VPUCM_RS03040	COG0517	IMP dehydrogenase activity
VPUCM_RS03045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VPUCM_RS03045	COG0519	Catalyzes the synthesis of GMP from XMP
VPUCM_RS03050	COG0582	viral genome integration into host DNA
VPUCM_RS03120	COG1757	Na H antiporter
VPUCM_RS03130	COG1584	GPR1 FUN34 yaaH family protein
VPUCM_RS03140	COG1115	amino acid carrier protein
VPUCM_RS03170	COG2873	o-acetylhomoserine
VPUCM_RS03175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VPUCM_RS03195	COG3153	acetyltransferase
VPUCM_RS03195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VPUCM_RS03200	COG0583	DNA-binding transcription factor activity
VPUCM_RS03225	COG1401	restriction endodeoxyribonuclease activity
VPUCM_RS03240	COG2801	Transposase and inactivated derivatives
VPUCM_RS03245	COG2963	transposase activity
VPUCM_RS03250	COG0582	viral genome integration into host DNA
VPUCM_RS03255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VPUCM_RS03260	COG2867	negative regulation of translational initiation
VPUCM_RS03265	COG2914	Belongs to the UPF0125 (RnfH) family
VPUCM_RS03270	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPUCM_RS03275	COG0497	DNA recombination
VPUCM_RS03285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VPUCM_RS03290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VPUCM_RS03300	COG0443	Heat shock 70 kDa protein
VPUCM_RS03305	COG0484	heat shock protein binding
VPUCM_RS03335	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VPUCM_RS03350	COG2027	D-alanyl-D-alanine carboxypeptidase
VPUCM_RS03355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VPUCM_RS03360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPUCM_RS03365	COG1534	Rna-binding protein
VPUCM_RS03370	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VPUCM_RS03375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VPUCM_RS03380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VPUCM_RS03385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPUCM_RS03395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VPUCM_RS03410	COG0779	Required for maturation of 30S ribosomal subunits
VPUCM_RS03415	COG0195	Participates in both transcription termination and antitermination
VPUCM_RS03420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VPUCM_RS03425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VPUCM_RS03430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VPUCM_RS03435	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VPUCM_RS03440	COG1185	polyribonucleotide nucleotidyltransferase activity
VPUCM_RS03455	COG0534	Mate efflux family protein
VPUCM_RS03460	COG0826	peptidase U32
VPUCM_RS03465	COG0826	peptidase U32
VPUCM_RS03475	COG3154	lipid carrier protein
VPUCM_RS03480	COG3153	acetyltransferase
VPUCM_RS03530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VPUCM_RS03565	COG3293	Transposase
VPUCM_RS03580	COG0071	Belongs to the small heat shock protein (HSP20) family
VPUCM_RS03585	COG0542	response to heat
VPUCM_RS03610	COG0501	Belongs to the peptidase M48B family
VPUCM_RS03615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VPUCM_RS03620	COG2176	DNA-directed DNA polymerase activity
VPUCM_RS03640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VPUCM_RS03745	COG0681	Belongs to the peptidase S26 family
VPUCM_RS03775	COG2356	endonuclease I
VPUCM_RS03790	COG0629	single-stranded DNA binding
VPUCM_RS03805	COG0714	Associated with various cellular activities
VPUCM_RS03830	COG2003	Belongs to the UPF0758 family
VPUCM_RS03870	COG2204	response regulator
VPUCM_RS03885	COG0071	Belongs to the small heat shock protein (HSP20) family
VPUCM_RS03890	COG0071	Belongs to the small heat shock protein (HSP20) family
VPUCM_RS03905	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VPUCM_RS03910	COG0443	Heat shock 70 kDa protein
VPUCM_RS03925	COG0542	response to heat
VPUCM_RS03940	COG0501	Belongs to the peptidase M48B family
VPUCM_RS03960	COG0191	fructose-bisphosphate aldolase activity
VPUCM_RS04035	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VPUCM_RS04045	COG0084	hydrolase, TatD family'
VPUCM_RS04050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VPUCM_RS04055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VPUCM_RS04060	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VPUCM_RS04065	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VPUCM_RS04070	COG0813	purine-nucleoside phosphorylase activity
VPUCM_RS04080	COG0560	Phosphoserine phosphatase
VPUCM_RS04090	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VPUCM_RS04095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPUCM_RS04100	COG0583	DNA-binding transcription factor activity
VPUCM_RS04110	COG1022	Amp-dependent synthetase and ligase
VPUCM_RS04115	COG2169	Transcriptional regulator
VPUCM_RS04140	COG4964	Belongs to the GSP D family
VPUCM_RS04200	COG0583	DNA-binding transcription factor activity
VPUCM_RS04205	COG0531	amino acid
VPUCM_RS04210	COG2731	YhcH YjgK YiaL family protein
VPUCM_RS04215	COG3250	beta-galactosidase activity
VPUCM_RS04220	COG1609	Transcriptional regulator
VPUCM_RS04225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VPUCM_RS04235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VPUCM_RS04240	COG2017	converts alpha-aldose to the beta-anomer
VPUCM_RS04255	COG2176	DNA-directed DNA polymerase activity
VPUCM_RS04260	COG1609	Transcriptional regulator
VPUCM_RS04265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPUCM_RS04280	COG0598	Magnesium transport protein CorA
VPUCM_RS04285	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VPUCM_RS04290	COG1349	DNA-binding transcription factor activity
VPUCM_RS04295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VPUCM_RS04300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VPUCM_RS04305	COG2271	Major facilitator Superfamily
VPUCM_RS04310	COG0584	glycerophosphoryl diester phosphodiesterase
VPUCM_RS04315	COG2171	N-acyltransferase activity
VPUCM_RS04320	COG3141	response to X-ray
VPUCM_RS04340	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VPUCM_RS04350	COG1074	ATP-dependent DNA helicase activity
VPUCM_RS04355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VPUCM_RS04370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VPUCM_RS04370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VPUCM_RS04380	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VPUCM_RS04385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VPUCM_RS04390	COG2166	iron-sulfur cluster assembly
VPUCM_RS04395	COG3706	GGDEF domain
VPUCM_RS04400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VPUCM_RS04405	COG0693	protein deglycase activity
VPUCM_RS04410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VPUCM_RS04435	COG1595	DNA-templated transcription, initiation
VPUCM_RS04455	COG3056	Lipoprotein
VPUCM_RS04460	COG2813	Specifically methylates the guanine in position
VPUCM_RS04465	COG0271	Belongs to the BolA IbaG family
VPUCM_RS04475	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPUCM_RS04480	COG1805	sodium ion transport
VPUCM_RS04485	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPUCM_RS04490	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPUCM_RS04495	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPUCM_RS04500	COG2871	sodium ion transport
VPUCM_RS04505	COG1477	protein flavinylation
VPUCM_RS04520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VPUCM_RS04525	COG0514	ATP-dependent DNA helicase (RecQ)
VPUCM_RS04530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPUCM_RS04545	COG0733	neurotransmitter:sodium symporter activity
VPUCM_RS04565	COG0442	prolyl-tRNA aminoacylation
VPUCM_RS04570	COG1720	tRNA m6t6A37 methyltransferase activity
VPUCM_RS04575	COG0254	rRNA binding
VPUCM_RS04580	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VPUCM_RS04585	COG1671	Belongs to the UPF0178 family
VPUCM_RS04610	COG0564	pseudouridine synthase activity
VPUCM_RS04620	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VPUCM_RS04625	COG0024	Methionine aminopeptidase
VPUCM_RS04630	COG0052	Belongs to the universal ribosomal protein uS2 family
VPUCM_RS04635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VPUCM_RS04640	COG0528	UMP kinase activity
VPUCM_RS04645	COG0233	cytoplasmic translational termination
VPUCM_RS04650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VPUCM_RS04655	COG0575	Belongs to the CDS family
VPUCM_RS04660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VPUCM_RS04665	COG0750	zinc metalloprotease
VPUCM_RS04675	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VPUCM_RS04680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPUCM_RS04685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPUCM_RS04690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPUCM_RS04695	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPUCM_RS04700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VPUCM_RS04705	COG0587	DNA-directed DNA polymerase activity
VPUCM_RS04710	COG0825	malonyl-CoA metabolic process
VPUCM_RS04715	COG0037	tRNA processing
VPUCM_RS04725	COG0347	Belongs to the P(II) protein family
VPUCM_RS04730	COG3021	interspecies interaction between organisms
VPUCM_RS04740	COG1388	LysM domain
VPUCM_RS04740	COG0741	lytic transglycosylase activity
VPUCM_RS04745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VPUCM_RS04750	COG2226	methyltransferase
VPUCM_RS04755	COG0328	RNA-DNA hybrid ribonuclease activity
VPUCM_RS04760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VPUCM_RS04780	COG0456	acetyltransferase
VPUCM_RS04790	COG1960	acyl-CoA dehydrogenase activity
VPUCM_RS04795	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VPUCM_RS04800	COG0121	glutamine amidotransferase
VPUCM_RS04805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VPUCM_RS04810	COG1121	(ABC) transporter
VPUCM_RS04815	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VPUCM_RS04820	COG4977	sequence-specific DNA binding
VPUCM_RS04825	COG1918	ferrous iron import across plasma membrane
VPUCM_RS04845	COG0018	arginyl-trna synthetase
VPUCM_RS04850	COG3102	Protein conserved in bacteria
VPUCM_RS04855	COG0788	formyltetrahydrofolate deformylase activity
VPUCM_RS04860	COG1199	ATP-dependent helicase activity
VPUCM_RS04865	COG1214	PFAM Peptidase M22, glycoprotease
VPUCM_RS04880	COG2267	carboxylic ester hydrolase activity
VPUCM_RS04885	COG0318	PFAM AMP-dependent synthetase and ligase
VPUCM_RS04890	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VPUCM_RS04895	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VPUCM_RS04900	COG2894	cell division
VPUCM_RS04905	COG0850	regulation of cytokinetic process
VPUCM_RS04910	COG3100	YcgL domain-containing protein
VPUCM_RS04915	COG2951	lytic endotransglycosylase activity
VPUCM_RS04920	COG0583	DNA-binding transcription factor activity
VPUCM_RS04925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VPUCM_RS04930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VPUCM_RS04950	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_RS04960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VPUCM_RS04985	COG2986	histidine ammonia-lyase
VPUCM_RS04990	COG1216	Glycosyl transferase, family 2
VPUCM_RS04995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPUCM_RS05010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VPUCM_RS05015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VPUCM_RS05050	COG1253	flavin adenine dinucleotide binding
VPUCM_RS05055	COG0513	Belongs to the DEAD box helicase family
VPUCM_RS05060	COG0569	domain protein
VPUCM_RS05065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPUCM_RS05080	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VPUCM_RS05085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VPUCM_RS05090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VPUCM_RS05095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VPUCM_RS05105	COG2204	response regulator
VPUCM_RS05120	COG0544	peptidyl-prolyl cis-trans isomerase activity
VPUCM_RS05130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VPUCM_RS05135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VPUCM_RS05140	COG0776	regulation of translation
VPUCM_RS05145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VPUCM_RS05150	COG1555	photosystem II stabilization
VPUCM_RS05165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VPUCM_RS05170	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VPUCM_RS05175	COG0436	Aminotransferase
VPUCM_RS05180	COG1169	isochorismate synthase
VPUCM_RS05185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VPUCM_RS05190	COG0596	Alpha beta hydrolase
VPUCM_RS05195	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VPUCM_RS05215	COG2855	membrane
VPUCM_RS05220	COG0477	Major facilitator Superfamily
VPUCM_RS05270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPUCM_RS05295	COG1522	sequence-specific DNA binding
VPUCM_RS05305	COG1946	Acyl-CoA thioesterase
VPUCM_RS05310	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VPUCM_RS05325	COG2199	diguanylate cyclase activity
VPUCM_RS05390	COG5290	Psort location Cytoplasmic, score
VPUCM_RS05405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPUCM_RS05410	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VPUCM_RS05415	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VPUCM_RS05420	COG0516	GMP reductase activity
VPUCM_RS05420	COG0517	IMP dehydrogenase activity
VPUCM_RS05445	COG0537	adenosine 5'-monophosphoramidase activity
VPUCM_RS05470	COG3150	esterase
VPUCM_RS05475	COG1252	NADH dehydrogenase
VPUCM_RS05490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VPUCM_RS05500	COG4591	ABC-type transport system involved in lipoprotein release permease component
VPUCM_RS05505	COG1136	(ABC) transporter
VPUCM_RS05510	COG4591	ABC-type transport system involved in lipoprotein release permease component
VPUCM_RS05520	COG2333	competence protein COMEC
VPUCM_RS05520	COG0658	competence protein
VPUCM_RS05525	COG1132	(ABC) transporter
VPUCM_RS05530	COG1663	tetraacyldisaccharide 4'-kinase activity
VPUCM_RS05540	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VPUCM_RS05545	COG2719	SpoVR family
VPUCM_RS05550	COG2718	Belongs to the UPF0229 family
VPUCM_RS05555	COG2766	serine protein kinase
VPUCM_RS05560	COG3013	Belongs to the UPF0304 family
VPUCM_RS05570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPUCM_RS05580	COG1882	Formate acetyltransferase
VPUCM_RS05625	COG0556	nucleotide-excision repair
VPUCM_RS05630	COG2204	response regulator
VPUCM_RS05635	COG2198	Histidine kinase
VPUCM_RS05640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VPUCM_RS05645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VPUCM_RS05650	COG0521	Mo-molybdopterin cofactor biosynthetic process
VPUCM_RS05655	COG0315	cyclic pyranopterin monophosphate synthase activity
VPUCM_RS05660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VPUCM_RS05665	COG0314	molybdopterin synthase activity
VPUCM_RS05675	COG0601	transmembrane transport
VPUCM_RS05680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPUCM_RS05685	COG0444	Belongs to the ABC transporter superfamily
VPUCM_RS05695	COG0435	Glutathione S-transferase
VPUCM_RS05705	COG3174	membrane
VPUCM_RS05710	COG0280	phosphate acetyltransferase
VPUCM_RS05710	COG0857	belongs to the CobB CobQ family
VPUCM_RS05715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VPUCM_RS05720	COG3092	negative regulation of chromosome organization
VPUCM_RS05730	COG4120	Belongs to the binding-protein-dependent transport system permease family
VPUCM_RS05735	COG1122	ATPase activity
VPUCM_RS05740	COG0366	Alpha amylase catalytic
VPUCM_RS05750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VPUCM_RS05760	COG3766	membrane
VPUCM_RS05770	COG0754	glutathionylspermidine amidase activity
VPUCM_RS05780	COG0784	Response regulator, receiver
VPUCM_RS05780	COG5002	protein histidine kinase activity
VPUCM_RS05800	COG2801	Transposase and inactivated derivatives
VPUCM_RS05805	COG2963	transposase activity
VPUCM_RS05850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VPUCM_RS05900	COG0840	transmembrane signaling receptor activity
VPUCM_RS05905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_RS05910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPUCM_RS05935	COG3568	Endonuclease Exonuclease Phosphatase
VPUCM_RS05950	COG0583	DNA-binding transcription factor activity
VPUCM_RS05960	COG0686	Belongs to the AlaDH PNT family
VPUCM_RS05970	COG1674	ftsk spoiiie
VPUCM_RS05975	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VPUCM_RS05980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VPUCM_RS05985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VPUCM_RS06000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VPUCM_RS06005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VPUCM_RS06010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VPUCM_RS06015	COG0156	8-amino-7-oxononanoate synthase activity
VPUCM_RS06025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VPUCM_RS06030	COG0501	Belongs to the peptidase M48B family
VPUCM_RS06040	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_RS06055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VPUCM_RS06075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VPUCM_RS06080	COG2915	High frequency lysogenization protein hflD homolog
VPUCM_RS06085	COG0482	sulfurtransferase activity
VPUCM_RS06095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPUCM_RS06105	COG1757	Na H antiporter
VPUCM_RS06120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VPUCM_RS06125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VPUCM_RS06130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VPUCM_RS06135	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VPUCM_RS06135	COG0131	Imidazoleglycerol-phosphate dehydratase
VPUCM_RS06140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VPUCM_RS06145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VPUCM_RS06150	COG0107	imidazoleglycerol-phosphate synthase activity
VPUCM_RS06155	COG0140	phosphoribosyl-ATP diphosphatase activity
VPUCM_RS06155	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VPUCM_RS06160	COG3012	SEC-C Motif Domain Protein
VPUCM_RS06165	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VPUCM_RS06170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPUCM_RS06175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VPUCM_RS06180	COG0215	cysteine-tRNA ligase activity
VPUCM_RS06185	COG1435	thymidine kinase activity
VPUCM_RS06235	COG3850	Histidine kinase
VPUCM_RS06235	COG5002	protein histidine kinase activity
VPUCM_RS06240	COG0745	RESPONSE REGULATOR receiver
VPUCM_RS06245	COG0840	transmembrane signaling receptor activity
VPUCM_RS06250	COG1032	radical SAM domain protein
VPUCM_RS06255	COG3706	GGDEF domain
VPUCM_RS06255	COG5001	Diguanylate cyclase
VPUCM_RS06255	COG4251	negative regulation of phosphorylation
VPUCM_RS06255	COG2203	Gaf domain
VPUCM_RS06270	COG0583	DNA-binding transcription factor activity
VPUCM_RS06275	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VPUCM_RS06285	COG2350	Protein conserved in bacteria
VPUCM_RS06295	COG2917	probably involved in intracellular septation
VPUCM_RS06315	COG1301	dicarboxylic acid transport
VPUCM_RS06320	COG0318	PFAM AMP-dependent synthetase and ligase
VPUCM_RS06325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPUCM_RS06330	COG0159	tryptophan synthase activity
VPUCM_RS06335	COG0133	tryptophan synthase activity
VPUCM_RS06340	COG0135	phosphoribosylanthranilate isomerase activity
VPUCM_RS06340	COG0134	indole-3-glycerol-phosphate synthase activity
VPUCM_RS06345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VPUCM_RS06350	COG0512	Glutamine amidotransferase of anthranilate synthase
VPUCM_RS06355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VPUCM_RS06365	COG0613	PHP domain protein
VPUCM_RS06370	COG0009	L-threonylcarbamoyladenylate synthase
VPUCM_RS06380	COG1187	pseudouridine synthase activity
VPUCM_RS06385	COG3099	Belongs to the UPF0263 family
VPUCM_RS06390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VPUCM_RS06400	COG0417	DNA replication proofreading
VPUCM_RS06405	COG2197	response regulator
VPUCM_RS06410	COG0322	excinuclease ABC activity
VPUCM_RS06450	COG0019	diaminopimelate decarboxylase activity
VPUCM_RS06475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VPUCM_RS06480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VPUCM_RS06485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VPUCM_RS06505	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VPUCM_RS06515	COG0437	4 iron, 4 sulfur cluster binding
VPUCM_RS06520	COG3301	Polysulphide reductase, NrfD
VPUCM_RS06525	COG1138	Cytochrome C-type biogenesis protein
VPUCM_RS06535	COG4235	cytochrome complex assembly
VPUCM_RS06535	COG3088	subunit of a heme lyase
VPUCM_RS06545	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VPUCM_RS06570	COG2989	Protein conserved in bacteria
VPUCM_RS06575	COG3108	Peptidase M15
VPUCM_RS06580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VPUCM_RS06595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VPUCM_RS06620	COG1846	Transcriptional regulator
VPUCM_RS06625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPUCM_RS06630	COG0840	transmembrane signaling receptor activity
VPUCM_RS06650	COG1448	Aminotransferase
VPUCM_RS06665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPUCM_RS06675	COG0017	Asparaginyl-tRNA synthetase
VPUCM_RS06685	COG0720	synthase
VPUCM_RS06695	COG2200	EAL domain
VPUCM_RS06700	COG1760	l-serine dehydratase
VPUCM_RS06705	COG0814	amino acid
VPUCM_RS06710	COG0494	nUDIX hydrolase
VPUCM_RS06720	COG0784	Response regulator, receiver
VPUCM_RS06720	COG2205	protein histidine kinase activity
VPUCM_RS06725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VPUCM_RS06740	COG3106	COG3106 Predicted ATPase
VPUCM_RS06745	COG3768	UPF0283 membrane protein
VPUCM_RS06755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VPUCM_RS06810	COG1335	isochorismatase
VPUCM_RS06930	COG1280	lysine exporter protein (LysE YggA)
VPUCM_RS06945	COG0346	lactoylglutathione lyase activity
VPUCM_RS06960	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_RS07085	COG0456	acetyltransferase
VPUCM_RS07125	COG2963	transposase activity
VPUCM_RS07130	COG2801	Transposase and inactivated derivatives
VPUCM_RS07480	COG2963	transposase activity
VPUCM_RS07525	COG2204	response regulator
VPUCM_RS07555	COG1793	dna ligase
VPUCM_RS07565	COG0534	Mate efflux family protein
VPUCM_RS07570	COG0307	riboflavin synthase, alpha
VPUCM_RS07580	COG3001	Fructosamine kinase
VPUCM_RS07585	COG2201	protein-glutamate methylesterase activity
VPUCM_RS07590	COG3706	GGDEF domain
VPUCM_RS07600	COG0791	NLP P60 protein
VPUCM_RS07605	COG0840	transmembrane signaling receptor activity
VPUCM_RS07640	COG3148	PFAM DTW domain containing protein
VPUCM_RS07645	COG1940	carbohydrate kinase activity
VPUCM_RS07675	COG0471	metal ion transport
VPUCM_RS07680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_RS07680	COG4191	Histidine kinase
VPUCM_RS07690	COG5001	Diguanylate cyclase
VPUCM_RS07690	COG3300	MHYT domain
VPUCM_RS07700	COG1280	lysine exporter protein (LysE YggA)
VPUCM_RS07705	COG1328	CTP reductase activity
VPUCM_RS07710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPUCM_RS07720	COG0861	Integral membrane protein TerC family
VPUCM_RS07730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VPUCM_RS07740	COG0814	amino acid
VPUCM_RS07760	COG1132	(ABC) transporter
VPUCM_RS07765	COG1132	(ABC) transporter
VPUCM_RS07790	COG0443	Heat shock 70 kDa protein
VPUCM_RS07795	COG0443	Heat shock 70 kDa protein
VPUCM_RS07835	COG0243	molybdopterin cofactor binding
VPUCM_RS07840	COG0437	4 iron, 4 sulfur cluster binding
VPUCM_RS07845	COG3302	dmso reductase anchor subunit
VPUCM_RS07860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VPUCM_RS07865	COG1643	Atp-dependent helicase
VPUCM_RS07880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPUCM_RS07890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VPUCM_RS07895	COG1215	transferase activity, transferring glycosyl groups
VPUCM_RS07900	COG0438	transferase activity, transferring glycosyl groups
VPUCM_RS07910	COG0303	'Molybdopterin
VPUCM_RS07915	COG0746	molybdenum cofactor guanylyltransferase activity
VPUCM_RS07920	COG3842	ATPase activity
VPUCM_RS07935	COG2204	response regulator
VPUCM_RS07940	COG4191	Histidine kinase
VPUCM_RS07945	COG0488	(ABC) transporter
VPUCM_RS07955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VPUCM_RS07975	COG3381	protein complex oligomerization
VPUCM_RS07985	COG0243	molybdopterin cofactor binding
VPUCM_RS07985	COG3383	formate dehydrogenase (NAD+) activity
VPUCM_RS07990	COG0437	4 iron, 4 sulfur cluster binding
VPUCM_RS08005	COG3209	COG3209 Rhs family protein
VPUCM_RS08075	COG0004	ammonium transporteR
VPUCM_RS08085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VPUCM_RS08090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VPUCM_RS08100	COG1177	transmembrane transport
VPUCM_RS08110	COG3842	ATPase activity
VPUCM_RS08130	COG0037	tRNA processing
VPUCM_RS08135	COG0589	response to stress
VPUCM_RS08140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPUCM_RS08155	COG2217	Heavy metal translocating P-type atpase
VPUCM_RS08165	COG2010	Cytochrome c
VPUCM_RS08180	COG3278	Belongs to the heme-copper respiratory oxidase family
VPUCM_RS08195	COG2205	protein histidine kinase activity
VPUCM_RS08195	COG0784	Response regulator, receiver
VPUCM_RS08310	COG3120	sequence-specific DNA binding
VPUCM_RS08315	COG1067	ATP-dependent peptidase activity
VPUCM_RS08320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPUCM_RS08335	COG0488	(ABC) transporter
VPUCM_RS08345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VPUCM_RS08345	COG0116	Belongs to the methyltransferase superfamily
VPUCM_RS08355	COG0167	dihydroorotate dehydrogenase activity
VPUCM_RS08360	COG2902	Dehydrogenase
VPUCM_RS08365	COG0308	aminopeptidase N
VPUCM_RS08380	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VPUCM_RS08385	COG1956	GAF domain-containing protein
VPUCM_RS08390	COG1132	(ABC) transporter
VPUCM_RS08395	COG2995	paraquat-inducible protein a
VPUCM_RS08400	COG3008	intermembrane lipid transfer
VPUCM_RS08405	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VPUCM_RS08405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VPUCM_RS08425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VPUCM_RS08430	COG1666	GTP binding
VPUCM_RS08440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_RS08445	COG4597	amino acid ABC transporter
VPUCM_RS08450	COG0765	amino acid transport
VPUCM_RS08455	COG1126	abc transporter atp-binding protein
VPUCM_RS08460	COG0670	Belongs to the BI1 family
VPUCM_RS08470	COG2920	part of a sulfur-relay system
VPUCM_RS08475	COG1254	Belongs to the acylphosphatase family
VPUCM_RS08480	COG0840	transmembrane signaling receptor activity
VPUCM_RS08485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VPUCM_RS08530	COG3706	GGDEF domain
VPUCM_RS08535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VPUCM_RS08540	COG0602	queuosine metabolic process
VPUCM_RS08545	COG0561	phosphatase activity
VPUCM_RS08570	COG2828	Protein conserved in bacteria
VPUCM_RS08580	COG0372	Belongs to the citrate synthase family
VPUCM_RS08585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VPUCM_RS08615	COG0730	response to heat
VPUCM_RS08635	COG0457	Tetratricopeptide repeat
VPUCM_RS08705	COG4790	Type iii secretion
VPUCM_RS08710	COG4794	Type iii secretion
VPUCM_RS08715	COG4791	protein targeting
VPUCM_RS08720	COG4792	protein secretion
VPUCM_RS08730	COG1073	alpha beta
VPUCM_RS08735	COG1073	alpha beta
VPUCM_RS08765	COG3177	Filamentation induced by cAMP protein fic
VPUCM_RS08785	COG4669	(LipO)protein
VPUCM_RS08855	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_RS08860	COG3284	Transcriptional regulator
VPUCM_RS08875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VPUCM_RS08880	COG0363	glucosamine-6-phosphate deaminase activity
VPUCM_RS08885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VPUCM_RS08890	COG4565	transcriptional regulatory protein
VPUCM_RS08895	COG3290	protein histidine kinase activity
VPUCM_RS08910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_RS08925	COG1858	cytochrome C peroxidase
VPUCM_RS08940	COG0527	aspartate kinase activity
VPUCM_RS08945	COG0662	Cupin 2, conserved barrel domain protein
VPUCM_RS08950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VPUCM_RS08955	COG0456	acetyltransferase
VPUCM_RS08960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPUCM_RS08980	COG4176	ABC-type proline glycine betaine transport system permease component
VPUCM_RS08985	COG2113	Glycine betaine
VPUCM_RS09005	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_RS09015	COG0745	RESPONSE REGULATOR receiver
VPUCM_RS09020	COG0642	Histidine kinase
VPUCM_RS09025	COG1368	sulfuric ester hydrolase activity
VPUCM_RS09050	COG1115	amino acid carrier protein
VPUCM_RS09060	COG1280	lysine exporter protein (LysE YggA)
VPUCM_RS09065	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VPUCM_RS09070	COG1560	Kdo2-lipid A biosynthetic process
VPUCM_RS09080	COG0531	amino acid
VPUCM_RS09090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VPUCM_RS09095	COG3063	Type IV pilus biogenesis stability protein PilW
VPUCM_RS09110	COG5002	protein histidine kinase activity
VPUCM_RS09110	COG2205	protein histidine kinase activity
VPUCM_RS09110	COG0784	Response regulator, receiver
VPUCM_RS09125	COG0110	maltose O-acetyltransferase activity
VPUCM_RS09145	COG2315	Protein conserved in bacteria
VPUCM_RS09150	COG1846	Transcriptional regulator
VPUCM_RS09165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VPUCM_RS09180	COG2771	luxR family
VPUCM_RS09180	COG2200	EAL domain
VPUCM_RS09185	COG1227	inorganic diphosphatase activity
VPUCM_RS09190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VPUCM_RS09195	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_RS09200	COG2957	Belongs to the agmatine deiminase family
VPUCM_RS09210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VPUCM_RS09215	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_RS09220	COG1917	Cupin 2, conserved barrel domain protein
VPUCM_RS09220	COG1396	sequence-specific DNA binding
VPUCM_RS09225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VPUCM_RS09230	COG0174	glutamine synthetase
VPUCM_RS09235	COG1757	Na H antiporter
VPUCM_RS09255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VPUCM_RS09260	COG1280	lysine exporter protein (LysE YggA)
VPUCM_RS09300	COG0625	glutathione transferase activity
VPUCM_RS09310	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VPUCM_RS09325	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPUCM_RS09335	COG0601	transmembrane transport
VPUCM_RS09340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPUCM_RS09345	COG0444	Belongs to the ABC transporter superfamily
VPUCM_RS09360	COG3291	Pkd domain containing protein
VPUCM_RS09370	COG1177	transmembrane transport
VPUCM_RS09375	COG1176	ABC-type spermidine putrescine transport system, permease component I
VPUCM_RS09380	COG3842	ATPase activity
VPUCM_RS09385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VPUCM_RS09390	COG2423	ornithine cyclodeaminase activity
VPUCM_RS09405	COG3938	Belongs to the proline racemase family
VPUCM_RS09435	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VPUCM_RS09440	COG1451	nucleotide metabolic process
VPUCM_RS09450	COG0583	DNA-binding transcription factor activity
VPUCM_RS09470	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VPUCM_RS09475	COG4139	cobalamin transport
VPUCM_RS09480	COG2988	succinylglutamate desuccinylase activity
VPUCM_RS09490	COG2062	phosphohistidine phosphatase, SixA
VPUCM_RS09500	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VPUCM_RS09505	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VPUCM_RS09510	COG0702	epimerase
VPUCM_RS09515	COG1823	symporter activity
VPUCM_RS09520	COG2925	Exonuclease
VPUCM_RS09525	COG1380	Effector of murein hydrolase LrgA
VPUCM_RS09530	COG1346	cytolysis
VPUCM_RS09535	COG0295	cytidine deaminase activity
VPUCM_RS09540	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VPUCM_RS09545	COG0500	methyltransferase
VPUCM_RS09555	COG0776	regulation of translation
VPUCM_RS09565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPUCM_RS09565	COG0072	phenylalanine-tRNA ligase activity
VPUCM_RS09570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VPUCM_RS09575	COG3706	GGDEF domain
VPUCM_RS09605	COG0393	Putative heavy-metal-binding
VPUCM_RS09615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VPUCM_RS09625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VPUCM_RS09640	COG2188	Transcriptional regulator
VPUCM_RS09645	COG1228	amidohydrolase
VPUCM_RS09650	COG0010	Belongs to the arginase family
VPUCM_RS09655	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VPUCM_RS09660	COG2986	histidine ammonia-lyase
VPUCM_RS09675	COG0277	FAD linked oxidase domain protein
VPUCM_RS09675	COG0247	lactate metabolic process
VPUCM_RS09710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VPUCM_RS09725	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
VPUCM_RS09730	COG1643	Atp-dependent helicase
VPUCM_RS09735	COG0281	malic enzyme
VPUCM_RS09740	COG2949	membrane
VPUCM_RS09745	COG0471	metal ion transport
VPUCM_RS09770	COG0492	ferredoxin-NADP+ reductase activity
VPUCM_RS09775	COG4988	ABC transporter
VPUCM_RS09780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VPUCM_RS09785	COG3048	D-serine ammonia-lyase activity
VPUCM_RS09790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VPUCM_RS09800	COG4191	Histidine kinase
VPUCM_RS09800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_RS09815	COG3070	regulator of competence-specific genes
VPUCM_RS09830	COG2431	L-lysine efflux transmembrane transporter activity
VPUCM_RS09840	COG0076	glutamate decarboxylase activity
VPUCM_RS09845	COG1737	Transcriptional regulator
VPUCM_RS09855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VPUCM_RS09860	COG3273	potassium ion transport
VPUCM_RS09860	COG2985	domain, Protein
VPUCM_RS09865	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VPUCM_RS09880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPUCM_RS09895	COG4181	ATPase activity
VPUCM_RS09900	COG0534	Mate efflux family protein
VPUCM_RS09905	COG0702	epimerase
VPUCM_RS09910	COG3005	denitrification pathway
VPUCM_RS09940	COG2814	Major facilitator Superfamily
VPUCM_RS09945	COG1187	pseudouridine synthase activity
VPUCM_RS09950	COG1061	Type III restriction enzyme res subunit
VPUCM_RS09970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VPUCM_RS09995	COG2801	Transposase and inactivated derivatives
VPUCM_RS10000	COG2963	transposase activity
VPUCM_RS10005	COG3313	Fe-S protein
VPUCM_RS10030	COG0493	'glutamate synthase
VPUCM_RS10040	COG0398	Pfam SNARE associated Golgi protein
VPUCM_RS10045	COG4134	Bacterial extracellular solute-binding protein
VPUCM_RS10050	COG4135	transport system, permease component
VPUCM_RS10055	COG4136	ATPase activity
VPUCM_RS10060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VPUCM_RS10070	COG3604	Transcriptional regulator
VPUCM_RS10075	COG1151	hydroxylamine reductase activity
VPUCM_RS10080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VPUCM_RS10090	COG0564	pseudouridine synthase activity
VPUCM_RS10100	COG0733	neurotransmitter:sodium symporter activity
VPUCM_RS10110	COG0626	cystathionine gamma-synthase activity
VPUCM_RS10115	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VPUCM_RS10120	COG5380	lipid catabolic process
VPUCM_RS10125	COG2818	Glycosylase
VPUCM_RS10140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_RS10145	COG1983	PspC domain protein
VPUCM_RS10155	COG1842	Phage shock protein A
VPUCM_RS10160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VPUCM_RS10175	COG4171	peptide transport system, permease
VPUCM_RS10185	COG4172	Belongs to the ABC transporter superfamily
VPUCM_RS10195	COG1227	inorganic diphosphatase activity
VPUCM_RS10210	COG0243	molybdopterin cofactor binding
VPUCM_RS10215	COG3005	denitrification pathway
VPUCM_RS10220	COG4459	periplasmic nitrate reductase
VPUCM_RS10225	COG0390	transport system, permease component
VPUCM_RS10230	COG2116	formate transmembrane transporter activity
VPUCM_RS10255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VPUCM_RS10275	COG1335	isochorismatase
VPUCM_RS10280	COG0577	efflux transmembrane transporter activity
VPUCM_RS10280	COG1136	(ABC) transporter
VPUCM_RS10290	COG1136	(ABC) transporter
VPUCM_RS10290	COG0577	efflux transmembrane transporter activity
VPUCM_RS10300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_RS10330	COG3118	belongs to the thioredoxin family
VPUCM_RS10335	COG4232	protein-disulfide reductase activity
VPUCM_RS10375	COG2863	cytochrome
VPUCM_RS10380	COG3258	Cytochrome c
VPUCM_RS10385	COG2995	paraquat-inducible protein a
VPUCM_RS10390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VPUCM_RS10390	COG3008	intermembrane lipid transfer
VPUCM_RS10400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VPUCM_RS10425	COG4166	transmembrane transport
VPUCM_RS10430	COG0284	orotidine-5'-phosphate decarboxylase activity
VPUCM_RS10435	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VPUCM_RS10440	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VPUCM_RS10450	COG0539	negative regulation of cytoplasmic translation
VPUCM_RS10455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VPUCM_RS10460	COG0616	signal peptide processing
VPUCM_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_RS10480	COG0587	DNA-directed DNA polymerase activity
VPUCM_RS10485	COG0784	Response regulator, receiver
VPUCM_RS10485	COG0835	chemotaxis
VPUCM_RS10490	COG1940	carbohydrate kinase activity
VPUCM_RS10495	COG0469	pyruvate kinase activity
VPUCM_RS10500	COG4667	esterase of the alpha-beta hydrolase superfamily
VPUCM_RS10515	COG0733	neurotransmitter:sodium symporter activity
VPUCM_RS10525	COG1263	PTS System
VPUCM_RS10525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPUCM_RS10530	COG0084	hydrolase, TatD family'
VPUCM_RS10540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VPUCM_RS10545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VPUCM_RS10575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VPUCM_RS10580	COG0416	fatty acid biosynthetic process
VPUCM_RS10590	COG1399	metal-binding, possibly nucleic acid-binding protein
VPUCM_RS10595	COG0424	maF-like protein
VPUCM_RS10600	COG0564	pseudouridine synthase activity
VPUCM_RS10605	COG1530	ribonuclease E activity
VPUCM_RS10610	COG0659	secondary active sulfate transmembrane transporter activity
VPUCM_RS10615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VPUCM_RS10620	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VPUCM_RS10630	COG0572	uridine kinase
VPUCM_RS10635	COG0489	protein tyrosine kinase activity
VPUCM_RS10640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPUCM_RS10640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPUCM_RS10650	COG2186	Transcriptional regulator
VPUCM_RS10655	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPUCM_RS10660	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VPUCM_RS10665	COG3318	Belongs to the UPF0149 family
VPUCM_RS10665	COG3012	SEC-C Motif Domain Protein
VPUCM_RS10670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPUCM_RS10675	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VPUCM_RS10680	COG2885	chlorophyll binding
VPUCM_RS10685	COG0823	Involved in the tonB-independent uptake of proteins
VPUCM_RS10700	COG0811	peptide transport
VPUCM_RS10705	COG0824	Thioesterase
VPUCM_RS10720	COG1294	oxidase, subunit
VPUCM_RS10725	COG1271	oxidase subunit
VPUCM_RS10730	COG2255	four-way junction helicase activity
VPUCM_RS10735	COG0632	four-way junction helicase activity
VPUCM_RS10740	COG0840	transmembrane signaling receptor activity
VPUCM_RS10745	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VPUCM_RS10750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VPUCM_RS10755	COG1801	Protein of unknown function DUF72
VPUCM_RS10760	COG4106	trans-aconitate 2-methyltransferase activity
VPUCM_RS10765	COG0500	methyltransferase
VPUCM_RS10770	COG0189	ligase activity
VPUCM_RS10770	COG4067	protein conserved in archaea
VPUCM_RS10785	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VPUCM_RS10790	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VPUCM_RS10795	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VPUCM_RS10800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VPUCM_RS10805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VPUCM_RS10810	COG0745	RESPONSE REGULATOR receiver
VPUCM_RS10815	COG3381	protein complex oligomerization
VPUCM_RS10820	COG1609	Transcriptional regulator
VPUCM_RS10825	COG3070	regulator of competence-specific genes
VPUCM_RS10845	COG0297	glycogen (starch) synthase activity
VPUCM_RS10850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VPUCM_RS10855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPUCM_RS10865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VPUCM_RS10875	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VPUCM_RS10880	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VPUCM_RS10885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VPUCM_RS10895	COG0542	response to heat
VPUCM_RS10900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VPUCM_RS10905	COG1278	Cold shock
VPUCM_RS10915	COG1187	pseudouridine synthase activity
VPUCM_RS10920	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VPUCM_RS10930	COG1199	ATP-dependent helicase activity
VPUCM_RS10935	COG0730	response to heat
VPUCM_RS10940	COG3923	Primosomal replication protein n
VPUCM_RS10950	COG0708	Exodeoxyribonuclease III
VPUCM_RS10955	COG4657	Part of a membrane complex involved in electron transport
VPUCM_RS10960	COG2878	Part of a membrane complex involved in electron transport
VPUCM_RS10965	COG4656	Part of a membrane complex involved in electron transport
VPUCM_RS10970	COG4658	electron transport chain
VPUCM_RS10975	COG4659	FMN binding
VPUCM_RS10980	COG4660	Part of a membrane complex involved in electron transport
VPUCM_RS10985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VPUCM_RS10990	COG0346	lactoylglutathione lyase activity
VPUCM_RS11000	COG2885	chlorophyll binding
VPUCM_RS11005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VPUCM_RS11010	COG2056	Na+-H+ antiporter family
VPUCM_RS11020	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VPUCM_RS11040	COG1454	alcohol dehydrogenase
VPUCM_RS11040	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_RS11045	COG2095	MarC family integral membrane protein
VPUCM_RS11050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPUCM_RS11055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VPUCM_RS11060	COG1757	Na H antiporter
VPUCM_RS11075	COG3081	Nucleoid-associated protein
VPUCM_RS11080	COG3082	Protein of unknown function (DUF1414)
VPUCM_RS11085	COG3083	sulfuric ester hydrolase activity
VPUCM_RS11095	COG0123	including yeast histone deacetylase and acetoin utilization protein
VPUCM_RS11110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPUCM_RS11115	COG0778	Nitroreductase
VPUCM_RS11120	COG0446	pyridine nucleotide-disulphide oxidoreductase
VPUCM_RS11120	COG1902	pentaerythritol trinitrate reductase activity
VPUCM_RS11125	COG0616	signal peptide processing
VPUCM_RS11130	COG0252	asparaginase activity
VPUCM_RS11135	COG3139	Protein of unknown function (DUF1315)
VPUCM_RS11145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPUCM_RS11150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPUCM_RS11165	COG2226	methyltransferase
VPUCM_RS11180	COG1785	Belongs to the alkaline phosphatase family
VPUCM_RS11190	COG0346	lactoylglutathione lyase activity
VPUCM_RS11195	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VPUCM_RS11200	COG0668	transmembrane transport
VPUCM_RS11205	COG2983	Belongs to the UPF0260 family
VPUCM_RS11210	COG2261	transglycosylase associated protein
VPUCM_RS11225	COG3681	Belongs to the UPF0597 family
VPUCM_RS11230	COG0251	oxidation-reduction process
VPUCM_RS11235	COG0814	amino acid
VPUCM_RS11240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VPUCM_RS11245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VPUCM_RS11250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VPUCM_RS11260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VPUCM_RS11265	COG2832	Protein of unknown function (DUF454)
VPUCM_RS11275	COG0745	RESPONSE REGULATOR receiver
VPUCM_RS11280	COG0583	DNA-binding transcription factor activity
VPUCM_RS11290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VPUCM_RS11295	COG1286	toxin biosynthetic process
VPUCM_RS11300	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VPUCM_RS11305	COG0285	dihydrofolate synthase activity
VPUCM_RS11310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VPUCM_RS11315	COG0101	tRNA pseudouridine synthase activity
VPUCM_RS11325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VPUCM_RS11330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPUCM_RS11335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VPUCM_RS11340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VPUCM_RS11340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VPUCM_RS11345	COG0431	NADPH-dependent FMN reductase
VPUCM_RS11355	COG3101	peptidyl-lysine hydroxylation
VPUCM_RS11360	COG2860	membrane
VPUCM_RS11365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VPUCM_RS11370	COG2890	protein-(glutamine-N5) methyltransferase activity
VPUCM_RS11375	COG2840	Smr protein MutS2
VPUCM_RS11380	COG2062	phosphohistidine phosphatase, SixA
VPUCM_RS11395	COG1250	3-hydroxyacyl-CoA dehydrogenase
VPUCM_RS11395	COG1024	Enoyl-CoA hydratase
VPUCM_RS11400	COG0183	Belongs to the thiolase family
VPUCM_RS11415	COG2067	long-chain fatty acid transport protein
VPUCM_RS11420	COG2067	long-chain fatty acid transport protein
VPUCM_RS11425	COG2853	Lipoprotein
VPUCM_RS11440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VPUCM_RS11445	COG1138	Cytochrome C-type biogenesis protein
VPUCM_RS11450	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VPUCM_RS11455	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPUCM_RS11460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPUCM_RS11465	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPUCM_RS11470	COG4133	protoheme IX ABC transporter activity
VPUCM_RS11480	COG0835	chemotaxis
VPUCM_RS11490	COG1192	Involved in chromosome partitioning
VPUCM_RS11495	COG2201	protein-glutamate methylesterase activity
VPUCM_RS11500	COG2198	Histidine kinase
VPUCM_RS11500	COG0643	Histidine kinase
VPUCM_RS11500	COG0784	Response regulator, receiver
VPUCM_RS11505	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VPUCM_RS11545	COG1987	bacterial-type flagellum assembly
VPUCM_RS11595	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VPUCM_RS11605	COG1677	Flagellar hook-basal body complex protein FliE
VPUCM_RS11625	COG1516	flagellar protein fliS
VPUCM_RS11635	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VPUCM_RS11640	COG1334	flagellar protein FlaG
VPUCM_RS11645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_RS11650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_RS11655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_RS11660	COG2837	iron assimilation
VPUCM_RS11685	COG1393	Belongs to the ArsC family
VPUCM_RS11690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPUCM_RS11705	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VPUCM_RS11710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VPUCM_RS11715	COG2716	regulation of RNA biosynthetic process
VPUCM_RS11720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VPUCM_RS11735	COG4783	chaperone-mediated protein folding
VPUCM_RS11740	COG1393	Belongs to the ArsC family
VPUCM_RS11760	COG2233	PERMEase
VPUCM_RS11765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VPUCM_RS11770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VPUCM_RS11775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VPUCM_RS11785	COG0045	succinate-CoA ligase (ADP-forming) activity
VPUCM_RS11790	COG0508	dehydrogenase complex catalyzes the overall conversion of
VPUCM_RS11795	COG0567	Dehydrogenase, E1 component
VPUCM_RS11800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VPUCM_RS11805	COG1053	succinate dehydrogenase
VPUCM_RS11810	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VPUCM_RS11825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VPUCM_RS11835	COG0033	Phosphoglucomutase
VPUCM_RS11840	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VPUCM_RS11845	COG0596	Alpha beta hydrolase
VPUCM_RS11865	COG0735	belongs to the Fur family
VPUCM_RS11870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPUCM_RS11875	COG1263	PTS System
VPUCM_RS11875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPUCM_RS11880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VPUCM_RS11885	COG1940	carbohydrate kinase activity
VPUCM_RS11885	COG1846	Transcriptional regulator
VPUCM_RS11890	COG4651	solute:proton antiporter activity
VPUCM_RS11890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VPUCM_RS11895	COG0367	asparagine synthase
VPUCM_RS11900	COG0250	Participates in transcription elongation, termination and antitermination
VPUCM_RS11905	COG3104	oligopeptide transport
VPUCM_RS11910	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VPUCM_RS11915	COG0563	adenylate kinase activity
VPUCM_RS11920	COG0326	Molecular chaperone. Has ATPase activity
VPUCM_RS11925	COG3710	Transcriptional regulator
VPUCM_RS11945	COG0622	Phosphoesterase
VPUCM_RS11970	COG1090	epimerase
VPUCM_RS11975	COG0300	oxidoreductase activity
VPUCM_RS11980	COG3118	belongs to the thioredoxin family
VPUCM_RS11985	COG0457	Tetratricopeptide repeat
VPUCM_RS11985	COG3118	belongs to the thioredoxin family
VPUCM_RS11990	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
VPUCM_RS11995	COG1215	transferase activity, transferring glycosyl groups
VPUCM_RS12000	COG1215	transferase activity, transferring glycosyl groups
VPUCM_RS12020	COG2194	sulfuric ester hydrolase activity
VPUCM_RS12025	COG0330	HflC and HflK could
VPUCM_RS12045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VPUCM_RS12050	COG3115	cell septum assembly
VPUCM_RS12055	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VPUCM_RS12060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VPUCM_RS12065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_RS12070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VPUCM_RS12075	COG2190	(PTS) system
VPUCM_RS12080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_RS12085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_RS12090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_RS12095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_RS12105	COG1705	Flagellar rod assembly protein muramidase FlgJ
VPUCM_RS12105	COG3951	Flagellar rod assembly protein muramidase FlgJ
VPUCM_RS12110	COG1706	bacterial-type flagellum-dependent cell motility
VPUCM_RS12115	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VPUCM_RS12125	COG4787	bacterial-type flagellum-dependent cell motility
VPUCM_RS12140	COG1558	bacterial-type flagellum-dependent cell motility
VPUCM_RS12145	COG1815	bacterial-type flagellum-dependent cell motility
VPUCM_RS12150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VPUCM_RS12155	COG0784	Response regulator, receiver
VPUCM_RS12155	COG0835	chemotaxis
VPUCM_RS12205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPUCM_RS12210	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VPUCM_RS12220	COG2217	Heavy metal translocating P-type atpase
VPUCM_RS12220	COG2608	mercury ion transmembrane transporter activity
VPUCM_RS12255	COG2840	Smr protein MutS2
VPUCM_RS12260	COG1187	pseudouridine synthase activity
VPUCM_RS12265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VPUCM_RS12270	COG0737	Belongs to the 5'-nucleotidase family
VPUCM_RS12275	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VPUCM_RS12280	COG2912	Transglutaminase-like superfamily
VPUCM_RS12285	COG3094	Invasion gene expression up-regulator, SirB
VPUCM_RS12290	COG2890	protein-(glutamine-N5) methyltransferase activity
VPUCM_RS12295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VPUCM_RS12300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VPUCM_RS12305	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VPUCM_RS12310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VPUCM_RS12315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VPUCM_RS12320	COG0193	aminoacyl-tRNA hydrolase activity
VPUCM_RS12325	COG0012	GTP binding
VPUCM_RS12440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPUCM_RS12445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VPUCM_RS12450	COG1702	phosphate starvation-inducible protein PhoH
VPUCM_RS12455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VPUCM_RS12460	COG4535	Mg2 and Co2 transporter CorC
VPUCM_RS12465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VPUCM_RS12470	COG2888	peptidyl-tyrosine sulfation
VPUCM_RS12475	COG0495	leucyl-tRNA aminoacylation
VPUCM_RS12480	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VPUCM_RS12485	COG1466	dna polymerase III delta subunit
VPUCM_RS12490	COG0799	negative regulation of ribosome biogenesis
VPUCM_RS12495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VPUCM_RS12500	COG0768	penicillin binding
VPUCM_RS12505	COG0772	Belongs to the SEDS family
VPUCM_RS12510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VPUCM_RS12515	COG1686	Belongs to the peptidase S11 family
VPUCM_RS12520	COG2921	Belongs to the UPF0250 family
VPUCM_RS12525	COG0321	lipoyl(octanoyl) transferase activity
VPUCM_RS12530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VPUCM_RS12535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VPUCM_RS12540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VPUCM_RS12555	COG0366	Alpha amylase catalytic
VPUCM_RS12560	COG1263	PTS System
VPUCM_RS12560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPUCM_RS12570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VPUCM_RS12575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VPUCM_RS12580	COG2011	ABC-type metal ion transport system permease component
VPUCM_RS12585	COG1464	Belongs to the NlpA lipoprotein family
VPUCM_RS12590	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VPUCM_RS12600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VPUCM_RS12600	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VPUCM_RS12615	COG1611	Belongs to the LOG family
VPUCM_RS12620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPUCM_RS12630	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VPUCM_RS12635	COG2363	Small membrane protein
VPUCM_RS12645	COG0583	DNA-binding transcription factor activity
VPUCM_RS12650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPUCM_RS12650	COG0301	tRNA thio-modification
VPUCM_RS12655	COG2885	chlorophyll binding
VPUCM_RS12660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VPUCM_RS12665	COG1722	exodeoxyribonuclease VII activity
VPUCM_RS12670	COG0142	geranyltranstransferase activity
VPUCM_RS12675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VPUCM_RS12680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VPUCM_RS12685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VPUCM_RS12690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VPUCM_RS12710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPUCM_RS12710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPUCM_RS12715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VPUCM_RS12720	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VPUCM_RS12725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VPUCM_RS12735	COG1073	alpha beta
VPUCM_RS12740	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VPUCM_RS12745	COG2252	PERMEase
VPUCM_RS12750	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPUCM_RS12775	COG0047	phosphoribosylformylglycinamidine synthase activity
VPUCM_RS12775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VPUCM_RS12780	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VPUCM_RS12785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VPUCM_RS12790	COG0739	heme binding
VPUCM_RS12795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPUCM_RS12805	COG0316	Belongs to the HesB IscA family
VPUCM_RS12810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VPUCM_RS12815	COG0628	permease
VPUCM_RS12820	COG2813	Specifically methylates the guanine in position
VPUCM_RS12825	COG2205	protein histidine kinase activity
VPUCM_RS12825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_RS12825	COG0784	Response regulator, receiver
VPUCM_RS12825	COG2198	Histidine kinase
VPUCM_RS12830	COG0747	negative chemotaxis
VPUCM_RS12840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPUCM_RS12845	COG0444	Belongs to the ABC transporter superfamily
VPUCM_RS12850	COG4608	Belongs to the ABC transporter superfamily
VPUCM_RS12860	COG2971	BadF BadG BcrA BcrD
VPUCM_RS12875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPUCM_RS12880	COG3842	ATPase activity
VPUCM_RS12890	COG1840	ABC-type Fe3 transport system, periplasmic component
VPUCM_RS12895	COG0004	ammonium transporteR
VPUCM_RS12905	COG3112	Uncharacterised protein family (UPF0231)
VPUCM_RS12910	COG1049	propionate catabolic process, 2-methylcitrate cycle
VPUCM_RS12915	COG1752	Esterase of the alpha-beta hydrolase superfamily
VPUCM_RS12920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VPUCM_RS12925	COG1643	Atp-dependent helicase
VPUCM_RS12930	COG1489	DNA binding
VPUCM_RS12940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPUCM_RS12950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VPUCM_RS12955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VPUCM_RS12960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VPUCM_RS12965	COG1560	Kdo2-lipid A biosynthetic process
VPUCM_RS12970	COG0842	Transport permease protein
VPUCM_RS12975	COG1131	(ABC) transporter
VPUCM_RS12980	COG0659	secondary active sulfate transmembrane transporter activity
VPUCM_RS12985	COG0288	reversible hydration of carbon dioxide
VPUCM_RS13000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPUCM_RS13005	COG0508	dehydrogenase complex catalyzes the overall conversion of
VPUCM_RS13010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VPUCM_RS13015	COG2186	Transcriptional regulator
VPUCM_RS13025	COG0157	Belongs to the NadC ModD family
VPUCM_RS13035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPUCM_RS13040	COG1459	type II secretion system
VPUCM_RS13050	COG0237	dephospho-CoA kinase activity
VPUCM_RS13055	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VPUCM_RS13060	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VPUCM_RS13065	COG0335	large ribosomal subunit rRNA binding
VPUCM_RS13070	COG0336	Belongs to the RNA methyltransferase TrmD family
VPUCM_RS13075	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VPUCM_RS13080	COG0228	four-way junction DNA binding
VPUCM_RS13085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VPUCM_RS13090	COG4137	Cytochrome C assembly protein
VPUCM_RS13095	COG4536	flavin adenine dinucleotide binding
VPUCM_RS13100	COG1854	S-ribosylhomocysteine lyase activity
VPUCM_RS13110	COG2918	glutathione biosynthetic process
VPUCM_RS13115	COG0612	Peptidase, M16
VPUCM_RS13120	COG1238	metal cluster binding
VPUCM_RS13130	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VPUCM_RS13135	COG5016	pyruvate
VPUCM_RS13135	COG0511	ligase activity, forming carbon-carbon bonds
VPUCM_RS13140	COG3630	sodium ion export across plasma membrane
VPUCM_RS13200	COG0527	aspartate kinase activity
VPUCM_RS13205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VPUCM_RS13210	COG2137	regulation of response to DNA damage stimulus
VPUCM_RS13215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VPUCM_RS13220	COG1546	Belongs to the CinA family
VPUCM_RS13225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VPUCM_RS13230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VPUCM_RS13240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VPUCM_RS13245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VPUCM_RS13250	COG0585	pseudouridine synthase activity
VPUCM_RS13255	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VPUCM_RS13260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VPUCM_RS13265	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VPUCM_RS13270	COG0148	phosphopyruvate hydratase activity
VPUCM_RS13275	COG0504	CTP synthase activity
VPUCM_RS13280	COG3956	TIGRFAM MazG family protein
VPUCM_RS13285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VPUCM_RS13290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VPUCM_RS13300	COG0736	holo-[acyl-carrier-protein] synthase activity
VPUCM_RS13305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VPUCM_RS13310	COG1381	Involved in DNA repair and RecF pathway recombination
VPUCM_RS13315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VPUCM_RS13320	COG0571	ribonuclease III activity
VPUCM_RS13330	COG0481	GTPase activity
VPUCM_RS13335	COG3086	response to oxidative stress
VPUCM_RS13345	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VPUCM_RS13350	COG1595	DNA-templated transcription, initiation
VPUCM_RS13355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VPUCM_RS13360	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VPUCM_RS13365	COG0354	folic acid binding
VPUCM_RS13380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPUCM_RS13385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPUCM_RS13390	COG3079	Belongs to the UPF0149 family
VPUCM_RS13395	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VPUCM_RS13400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VPUCM_RS13405	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VPUCM_RS13410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPUCM_RS13420	COG0583	DNA-binding transcription factor activity
VPUCM_RS13430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VPUCM_RS13435	COG0668	transmembrane transport
VPUCM_RS13440	COG0191	fructose-bisphosphate aldolase activity
VPUCM_RS13445	COG0126	phosphoglycerate kinase activity
VPUCM_RS13450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPUCM_RS13455	COG4771	TonB-dependent receptor
VPUCM_RS13460	COG0583	DNA-binding transcription factor activity
VPUCM_RS13465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VPUCM_RS13475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VPUCM_RS13485	COG3091	SprT-like family
VPUCM_RS13490	COG2356	endonuclease I
VPUCM_RS13495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VPUCM_RS13500	COG0189	ligase activity
VPUCM_RS13505	COG1678	Uncharacterized ACR, COG1678
VPUCM_RS13510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VPUCM_RS13525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VPUCM_RS13530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VPUCM_RS13535	COG0762	integral membrane protein
VPUCM_RS13540	COG1872	DUF167
VPUCM_RS13550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VPUCM_RS13555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VPUCM_RS13560	COG2066	Belongs to the glutaminase family
VPUCM_RS13570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VPUCM_RS13580	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VPUCM_RS13585	COG0741	lytic transglycosylase activity
VPUCM_RS13625	COG0840	transmembrane signaling receptor activity
VPUCM_RS13655	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_RS13700	COG3437	response regulator, receiver
VPUCM_RS13710	COG3394	polysaccharide catabolic process
VPUCM_RS13715	COG1486	melibiose metabolic process
VPUCM_RS13720	COG1447	Phosphotransferase system cellobiose-specific component IIA
VPUCM_RS13725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VPUCM_RS13730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VPUCM_RS13735	COG0726	polysaccharide deacetylase
VPUCM_RS13780	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_RS13795	COG0795	lipopolysaccharide-transporting ATPase activity
VPUCM_RS13800	COG0795	lipopolysaccharide-transporting ATPase activity
VPUCM_RS13805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VPUCM_RS13810	COG2927	DNA polymerase III (CHI subunit)
VPUCM_RS13815	COG0525	valine-tRNA ligase activity
VPUCM_RS13885	COG2235	arginine
VPUCM_RS13890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VPUCM_RS13895	COG0540	Belongs to the ATCase OTCase family
VPUCM_RS13900	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VPUCM_RS13905	COG0251	oxidation-reduction process
VPUCM_RS13910	COG0204	Acyl-transferase
VPUCM_RS13915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VPUCM_RS13920	COG5007	Belongs to the BolA IbaG family
VPUCM_RS13930	COG2854	intermembrane phospholipid transfer
VPUCM_RS13935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VPUCM_RS13940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VPUCM_RS13945	COG1127	ABC transporter
VPUCM_RS13955	COG0517	IMP dehydrogenase activity
VPUCM_RS13955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VPUCM_RS13965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VPUCM_RS13970	COG1137	ATPase activity
VPUCM_RS13980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VPUCM_RS13985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_RS13990	COG1660	Displays ATPase and GTPase activities
VPUCM_RS13995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_RS14000	COG2239	Acts as a magnesium transporter
VPUCM_RS14005	COG0312	modulator of DNA gyrase
VPUCM_RS14010	COG3028	Belongs to the UPF0307 family
VPUCM_RS14015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VPUCM_RS14020	COG0564	pseudouridine synthase activity
VPUCM_RS14030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VPUCM_RS14035	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VPUCM_RS14040	COG0312	modulator of DNA gyrase
VPUCM_RS14045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VPUCM_RS14050	COG3164	Protein of unknown function
VPUCM_RS14060	COG0424	maF-like protein
VPUCM_RS14065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VPUCM_RS14070	COG1792	Involved in formation and maintenance of cell shape
VPUCM_RS14075	COG1077	Cell shape determining protein MreB Mrl
VPUCM_RS14110	COG2165	general secretion pathway protein
VPUCM_RS14120	COG1459	type II secretion system
VPUCM_RS14125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPUCM_RS14135	COG3267	Type II secretory pathway component ExeA
VPUCM_RS14135	COG3409	Peptidoglycan-binding domain 1 protein
VPUCM_RS14160	COG2200	EAL domain
VPUCM_RS14160	COG2199	diguanylate cyclase activity
VPUCM_RS14165	COG0629	single-stranded DNA binding
VPUCM_RS14180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VPUCM_RS14190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VPUCM_RS14200	COG0527	aspartate kinase activity
VPUCM_RS14205	COG0646	methionine synthase
VPUCM_RS14205	COG1410	methionine synthase
VPUCM_RS14250	COG0175	sulfate reduction
VPUCM_RS14255	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VPUCM_RS14260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VPUCM_RS14280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPUCM_RS14285	COG0735	belongs to the Fur family
VPUCM_RS14295	COG0166	Belongs to the GPI family
VPUCM_RS14300	COG0432	Pfam Uncharacterised protein family UPF0047
VPUCM_RS14310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPUCM_RS14325	COG0359	binds to the 23S rRNA
VPUCM_RS14335	COG2965	DNA replication, synthesis of RNA primer
VPUCM_RS14340	COG0360	Binds together with S18 to 16S ribosomal RNA
VPUCM_RS14345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VPUCM_RS14350	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VPUCM_RS14360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VPUCM_RS14365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VPUCM_RS14395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VPUCM_RS14405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VPUCM_RS14405	COG0678	peroxiredoxin activity
VPUCM_RS14415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VPUCM_RS14415	COG0165	Argininosuccinate lyase
VPUCM_RS14420	COG0137	argininosuccinate synthase activity
VPUCM_RS14425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VPUCM_RS14430	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VPUCM_RS14435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPUCM_RS14440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VPUCM_RS14450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VPUCM_RS14455	COG0527	aspartate kinase activity
VPUCM_RS14455	COG0460	homoserine dehydrogenase
VPUCM_RS14460	COG0626	cystathionine gamma-synthase activity
VPUCM_RS14470	COG0281	malic enzyme
VPUCM_RS14480	COG2906	2 iron, 2 sulfur cluster binding
VPUCM_RS14485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VPUCM_RS14490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPUCM_RS14495	COG0049	tRNA binding
VPUCM_RS14510	COG2923	Belongs to the DsrF TusC family
VPUCM_RS14515	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VPUCM_RS14520	COG2964	Protein conserved in bacteria
VPUCM_RS14525	COG0545	Peptidyl-prolyl cis-trans isomerase
VPUCM_RS14535	COG2900	Belongs to the SlyX family
VPUCM_RS14540	COG1446	asparaginase
VPUCM_RS14545	COG1047	Peptidyl-prolyl cis-trans
VPUCM_RS14560	COG2249	NAD(P)H dehydrogenase (quinone) activity
VPUCM_RS14565	COG0488	(ABC) transporter
VPUCM_RS14575	COG0429	hydrolase of the alpha beta-hydrolase fold
VPUCM_RS14580	COG3089	Belongs to the UPF0270 family
VPUCM_RS14585	COG3954	Phosphoribulokinase
VPUCM_RS14590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPUCM_RS14600	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_RS14610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VPUCM_RS14615	COG0512	Glutamine amidotransferase of anthranilate synthase
VPUCM_RS14630	COG0180	Tryptophanyl-tRNA synthetase
VPUCM_RS14635	COG0546	phosphoglycolate phosphatase activity
VPUCM_RS14640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPUCM_RS14645	COG0557	exoribonuclease II activity
VPUCM_RS14650	COG1959	2 iron, 2 sulfur cluster binding
VPUCM_RS14655	COG1017	nitric oxide dioxygenase activity
VPUCM_RS14655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VPUCM_RS14660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VPUCM_RS14665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VPUCM_RS14670	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VPUCM_RS14675	COG0330	HflC and HflK could
VPUCM_RS14680	COG0330	HflC and HflK could
VPUCM_RS14685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VPUCM_RS14695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VPUCM_RS14700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VPUCM_RS14710	COG0802	atpase or kinase
VPUCM_RS14715	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VPUCM_RS14790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VPUCM_RS14795	COG1162	GTPase activity
VPUCM_RS14800	COG0688	phosphatidylethanolamine metabolic process
VPUCM_RS14805	COG0471	metal ion transport
VPUCM_RS14820	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VPUCM_RS14830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPUCM_RS14835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VPUCM_RS14840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VPUCM_RS14845	COG1045	serine acetyltransferase
VPUCM_RS14850	COG4942	peptidase
VPUCM_RS14870	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VPUCM_RS14875	COG1053	succinate dehydrogenase
VPUCM_RS14880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VPUCM_RS14885	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VPUCM_RS14890	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VPUCM_RS14900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VPUCM_RS14905	COG1509	lysine 2,3-aminomutase activity
VPUCM_RS14910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPUCM_RS14930	COG0459	protein refolding
VPUCM_RS14940	COG0534	Mate efflux family protein
VPUCM_RS14945	COG0205	6-phosphofructokinase activity
VPUCM_RS14955	COG3678	ATP-independent chaperone mediated protein folding
VPUCM_RS14960	COG0745	RESPONSE REGULATOR receiver
VPUCM_RS14965	COG2205	protein histidine kinase activity
VPUCM_RS14975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VPUCM_RS14980	COG3030	protein affecting phage T7 exclusion by the F plasmid
VPUCM_RS14985	COG1027	Aspartate ammonia-lyase
VPUCM_RS14990	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VPUCM_RS14995	COG4232	protein-disulfide reductase activity
VPUCM_RS15005	COG3263	regulation of cellular component size
VPUCM_RS15015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VPUCM_RS15035	COG2205	protein histidine kinase activity
VPUCM_RS15035	COG0784	Response regulator, receiver
VPUCM_RS15040	COG2814	Major facilitator Superfamily
VPUCM_RS15055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VPUCM_RS15060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VPUCM_RS15065	COG0511	ligase activity, forming carbon-carbon bonds
VPUCM_RS15070	COG0439	Biotin carboxylase
VPUCM_RS15075	COG2264	protein methyltransferase activity
VPUCM_RS15080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPUCM_RS15085	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VPUCM_RS15090	COG2814	Major facilitator Superfamily
VPUCM_RS15095	COG0488	(ABC) transporter
VPUCM_RS15100	COG3706	GGDEF domain
VPUCM_RS15130	COG1982	Orn Lys Arg decarboxylase major
VPUCM_RS15135	COG0531	amino acid
VPUCM_RS15140	COG3710	Transcriptional regulator
VPUCM_RS15145	COG0789	Transcriptional regulator
VPUCM_RS15150	COG0138	bifunctional purine biosynthesis protein purh
VPUCM_RS15155	COG0151	Belongs to the GarS family
VPUCM_RS15170	COG1253	flavin adenine dinucleotide binding
VPUCM_RS15180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPUCM_RS15185	COG1573	uracil-dna glycosylase
VPUCM_RS15190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VPUCM_RS15205	COG2816	NAD+ diphosphatase activity
VPUCM_RS15210	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VPUCM_RS15215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VPUCM_RS15220	COG0085	RNA polymerase activity
VPUCM_RS15225	COG0222	ribosome binding
VPUCM_RS15230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VPUCM_RS15235	COG0081	regulation of translation
VPUCM_RS15240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VPUCM_RS15245	COG0250	Participates in transcription elongation, termination and antitermination
VPUCM_RS15250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VPUCM_RS15255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VPUCM_RS15290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VPUCM_RS15300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VPUCM_RS15340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VPUCM_RS15350	COG4206	TonB-dependent receptor
VPUCM_RS15355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VPUCM_RS15370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPUCM_RS15375	COG0534	Mate efflux family protein
VPUCM_RS15380	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VPUCM_RS15385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VPUCM_RS15390	COG2937	Belongs to the GPAT DAPAT family
VPUCM_RS15395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VPUCM_RS15400	COG3161	chorismate lyase activity
VPUCM_RS15405	COG1580	Controls the rotational direction of flagella during chemotaxis
VPUCM_RS15410	COG0705	Rhomboid family
VPUCM_RS15415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPUCM_RS15425	COG2177	Part of the ABC transporter FtsEX involved in
VPUCM_RS15430	COG2884	Cell division ATP-binding protein ftsE
VPUCM_RS15435	COG0552	protein localization to endoplasmic reticulum
VPUCM_RS15440	COG0742	ribosomal rna small subunit methyltransferase
VPUCM_RS15450	COG2095	MarC family integral membrane protein
VPUCM_RS15505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPUCM_RS15510	COG0640	Transcriptional regulator
VPUCM_RS15515	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VPUCM_RS15520	COG1280	lysine exporter protein (LysE YggA)
VPUCM_RS15525	COG2267	carboxylic ester hydrolase activity
VPUCM_RS15530	COG0561	phosphatase activity
VPUCM_RS15545	COG3148	PFAM DTW domain containing protein
VPUCM_RS15550	COG2200	EAL domain
VPUCM_RS15550	COG2199	diguanylate cyclase activity
VPUCM_RS15550	COG3287	FIST C domain
VPUCM_RS15555	COG1011	Hydrolase
VPUCM_RS15560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VPUCM_RS15570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VPUCM_RS15575	COG0019	diaminopimelate decarboxylase activity
VPUCM_RS15585	COG1965	Belongs to the frataxin family
VPUCM_RS15590	COG3072	Adenylate cyclase
VPUCM_RS15595	COG0181	hydroxymethylbilane synthase activity
VPUCM_RS15600	COG1587	Uroporphyrinogen-III synthase
VPUCM_RS15605	COG2959	enzyme of heme biosynthesis
VPUCM_RS15610	COG3071	HemY protein
VPUCM_RS15635	COG0633	Ferredoxin
VPUCM_RS15640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VPUCM_RS15655	COG3118	belongs to the thioredoxin family
VPUCM_RS15660	COG0513	Belongs to the DEAD box helicase family
VPUCM_RS15665	COG0248	Ppx GppA phosphatase
VPUCM_RS15670	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VPUCM_RS15680	COG0514	ATP-dependent DNA helicase (RecQ)
VPUCM_RS15685	COG2962	Rard protein
VPUCM_RS15695	COG1280	lysine exporter protein (LysE YggA)
VPUCM_RS15700	COG0405	Gamma-glutamyltransferase
VPUCM_RS15705	COG0210	DNA helicase
VPUCM_RS15715	COG3220	belongs to the UPF0276 family
VPUCM_RS15745	COG0006	proline dipeptidase activity
VPUCM_RS15745	COG0006	proline dipeptidase activity
VPUCM_RS15755	COG2022	thiamine diphosphate biosynthetic process
VPUCM_RS15760	COG2104	thiamine diphosphate biosynthetic process
VPUCM_RS15765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VPUCM_RS15770	COG0352	thiamine-phosphate diphosphorylase activity
VPUCM_RS15775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VPUCM_RS15780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VPUCM_RS15825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VPUCM_RS15835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VPUCM_RS15840	COG0408	coproporphyrinogen oxidase activity
VPUCM_RS15845	COG0009	L-threonylcarbamoyladenylate synthase
VPUCM_RS15850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VPUCM_RS15855	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VPUCM_RS15860	COG0551	DNA topoisomerase type I activity
VPUCM_RS15865	COG2922	Belongs to the Smg family
VPUCM_RS15870	COG0758	DNA mediated transformation
VPUCM_RS15880	COG0242	peptide deformylase activity
VPUCM_RS15885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VPUCM_RS15890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VPUCM_RS15890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VPUCM_RS15895	COG0569	domain protein
VPUCM_RS15900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPUCM_RS15910	COG1272	protein, Hemolysin III
VPUCM_RS15915	COG4326	sporulation control protein
VPUCM_RS15920	COG3084	Protein conserved in bacteria
VPUCM_RS15930	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VPUCM_RS15935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPUCM_RS15940	COG0204	Acyl-transferase
VPUCM_RS15950	COG0606	chelatase, subunit chli
VPUCM_RS15960	COG3978	acetolactate synthase activity
VPUCM_RS15965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VPUCM_RS15970	COG0129	dihydroxy-acid dehydratase activity
VPUCM_RS15980	COG0583	DNA-binding transcription factor activity
VPUCM_RS15985	COG2814	Major facilitator Superfamily
VPUCM_RS15990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_RS15995	COG0765	amino acid transport
VPUCM_RS16000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VPUCM_RS16005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VPUCM_RS16010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VPUCM_RS16015	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VPUCM_RS16020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VPUCM_RS16025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VPUCM_RS16040	COG0356	it plays a direct role in the translocation of protons across the membrane
VPUCM_RS16045	COG3312	ion transport
VPUCM_RS16050	COG1475	DNA binding
VPUCM_RS16055	COG1192	Involved in chromosome partitioning
VPUCM_RS16060	COG0357	Ribosomal RNA small subunit methyltransferase G
VPUCM_RS16065	COG0445	tRNA wobble uridine modification
VPUCM_RS16180	COG0751	glycine-tRNA ligase activity
VPUCM_RS16220	COG1024	Enoyl-CoA hydratase
VPUCM_RS16220	COG1250	3-hydroxyacyl-CoA dehydrogenase
VPUCM_RS16735	COG1217	gtp-binding protein TYPA
VPUCM_RS16760	COG1295	ribonuclease BN
VPUCM_RS16780	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VPUCM_RS16835	COG3156	type II secretion system protein K
VPUCM_RS16930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VPUCM_RS16945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VPUCM_RS17660	COG0737	Belongs to the 5'-nucleotidase family
VPUCM_RS17670	COG1648	precorrin-2 dehydrogenase activity
VPUCM_RS17670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VPUCM_RS17810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VPUCM_RS18155	COG0306	phosphate transporter
VPUCM_RS18560	COG0083	homoserine kinase activity
VPUCM_RS18650	COG3290	protein histidine kinase activity
VPUCM_RS18650	COG3829	transcription factor binding
VPUCM_RS18855	COG0542	response to heat
VPUCM_RS19335	COG0484	heat shock protein binding
VPUCM_RS19440	COG0779	Required for maturation of 30S ribosomal subunits
VPUCM_RS19870	COG0443	Heat shock 70 kDa protein
VPUCM_RS20455	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPUCM_RS20710	COG1960	acyl-CoA dehydrogenase activity
VPUCM_RS20775	COG0018	arginyl-trna synthetase
VPUCM_RS20790	COG1199	ATP-dependent helicase activity
VPUCM_RS20830	COG2951	lytic endotransglycosylase activity
VPUCM_RS20900	COG2986	histidine ammonia-lyase
VPUCM_RS20915	COG1216	Glycosyl transferase, family 2
VPUCM_RS21100	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VPUCM_RS21350	COG2217	Heavy metal translocating P-type atpase
VPUCM_RS21445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VPUCM_RS22115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPUCM_RS22740	COG3106	COG3106 Predicted ATPase
VPUCM_RS22760	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VPUCM_RS23290	COG0840	transmembrane signaling receptor activity
VPUCM_RS23425	COG0814	amino acid
VPUCM_RS23560	COG1643	Atp-dependent helicase
VPUCM_RS23625	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VPUCM_RS23650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VPUCM_RS24070	COG2610	gluconate transmembrane transporter activity
VPUCM_RS24100	COG0339	signal peptide processing
VPUCM_RS24165	COG1401	restriction endodeoxyribonuclease activity