locus-tag	class	description
D0853_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D0853_RS00010	COG0592	DNA-directed DNA polymerase activity
D0853_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0853_RS00020	COG0187	DNA topoisomerase II activity
D0853_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
D0853_RS00045	COG3977	Valine--pyruvate aminotransferase
D0853_RS00050	COG0366	Alpha amylase catalytic
D0853_RS00055	COG0751	glycine-tRNA ligase activity
D0853_RS00060	COG0752	glycyl-tRNA synthetase alpha subunit
D0853_RS00065	COG2119	membrane
D0853_RS00075	COG0425	Belongs to the sulfur carrier protein TusA family
D0853_RS00090	COG0604	alcohol dehydrogenase
D0853_RS00095	COG0183	Belongs to the thiolase family
D0853_RS00100	COG1024	Enoyl-CoA hydratase
D0853_RS00100	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0853_RS00105	COG1739	Uncharacterized protein family UPF0029
D0853_RS00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0853_RS00180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0853_RS00185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D0853_RS00190	COG0352	thiamine-phosphate diphosphorylase activity
D0853_RS00195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0853_RS00200	COG2104	thiamine diphosphate biosynthetic process
D0853_RS00205	COG2022	thiamine diphosphate biosynthetic process
D0853_RS00215	COG0006	proline dipeptidase activity
D0853_RS00215	COG0006	proline dipeptidase activity
D0853_RS00245	COG3220	belongs to the UPF0276 family
D0853_RS00255	COG0210	DNA helicase
D0853_RS00265	COG0405	Gamma-glutamyltransferase
D0853_RS00270	COG1280	lysine exporter protein (LysE YggA)
D0853_RS00280	COG2962	Rard protein
D0853_RS00285	COG0514	ATP-dependent DNA helicase (RecQ)
D0853_RS00300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D0853_RS00305	COG0248	Ppx GppA phosphatase
D0853_RS00310	COG0513	Belongs to the DEAD box helicase family
D0853_RS00315	COG3118	belongs to the thioredoxin family
D0853_RS00335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0853_RS00340	COG0633	Ferredoxin
D0853_RS00390	COG3071	HemY protein
D0853_RS00395	COG2959	enzyme of heme biosynthesis
D0853_RS00400	COG1587	Uroporphyrinogen-III synthase
D0853_RS00405	COG0181	hydroxymethylbilane synthase activity
D0853_RS00410	COG3072	Adenylate cyclase
D0853_RS00415	COG1965	Belongs to the frataxin family
D0853_RS00425	COG0019	diaminopimelate decarboxylase activity
D0853_RS00430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D0853_RS00440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D0853_RS00445	COG1011	Hydrolase
D0853_RS00450	COG2199	diguanylate cyclase activity
D0853_RS00450	COG3287	FIST C domain
D0853_RS00450	COG2200	EAL domain
D0853_RS00455	COG3148	PFAM DTW domain containing protein
D0853_RS00470	COG0561	phosphatase activity
D0853_RS00480	COG2267	carboxylic ester hydrolase activity
D0853_RS00485	COG1280	lysine exporter protein (LysE YggA)
D0853_RS00490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D0853_RS00495	COG0640	Transcriptional regulator
D0853_RS00500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0853_RS00555	COG2095	MarC family integral membrane protein
D0853_RS00565	COG0742	ribosomal rna small subunit methyltransferase
D0853_RS00570	COG0552	protein localization to endoplasmic reticulum
D0853_RS00575	COG2884	Cell division ATP-binding protein ftsE
D0853_RS00580	COG2177	Part of the ABC transporter FtsEX involved in
D0853_RS00595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0853_RS00600	COG0705	Rhomboid family
D0853_RS00605	COG1580	Controls the rotational direction of flagella during chemotaxis
D0853_RS00610	COG3161	chorismate lyase activity
D0853_RS00615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D0853_RS00620	COG2937	Belongs to the GPAT DAPAT family
D0853_RS00635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0853_RS00640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D0853_RS00645	COG0534	Mate efflux family protein
D0853_RS00650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0853_RS00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0853_RS00670	COG4206	TonB-dependent receptor
D0853_RS00680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D0853_RS00740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0853_RS00750	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0853_RS00785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0853_RS00795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0853_RS00800	COG0250	Participates in transcription elongation, termination and antitermination
D0853_RS00805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D0853_RS00810	COG0081	regulation of translation
D0853_RS00815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0853_RS00820	COG0222	ribosome binding
D0853_RS00825	COG0085	RNA polymerase activity
D0853_RS00830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D0853_RS00835	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D0853_RS00840	COG2816	NAD+ diphosphatase activity
D0853_RS00855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D0853_RS00860	COG1573	uracil-dna glycosylase
D0853_RS00865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0853_RS00875	COG1253	flavin adenine dinucleotide binding
D0853_RS00945	COG0151	Belongs to the GarS family
D0853_RS00955	COG0138	bifunctional purine biosynthesis protein purh
D0853_RS00965	COG0789	Transcriptional regulator
D0853_RS00970	COG3710	Transcriptional regulator
D0853_RS00980	COG0531	amino acid
D0853_RS00985	COG1982	Orn Lys Arg decarboxylase major
D0853_RS01070	COG3706	GGDEF domain
D0853_RS01075	COG0488	(ABC) transporter
D0853_RS01080	COG2814	Major facilitator Superfamily
D0853_RS01085	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D0853_RS01090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0853_RS01095	COG2264	protein methyltransferase activity
D0853_RS01105	COG0439	Biotin carboxylase
D0853_RS01110	COG0511	ligase activity, forming carbon-carbon bonds
D0853_RS01115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0853_RS01120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0853_RS01135	COG2814	Major facilitator Superfamily
D0853_RS01140	COG0784	Response regulator, receiver
D0853_RS01140	COG2205	protein histidine kinase activity
D0853_RS01165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0853_RS01175	COG3263	regulation of cellular component size
D0853_RS01185	COG4232	protein-disulfide reductase activity
D0853_RS01190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0853_RS01195	COG1027	Aspartate ammonia-lyase
D0853_RS01200	COG3030	protein affecting phage T7 exclusion by the F plasmid
D0853_RS01205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0853_RS01215	COG2205	protein histidine kinase activity
D0853_RS01220	COG0745	RESPONSE REGULATOR receiver
D0853_RS01230	COG3678	ATP-independent chaperone mediated protein folding
D0853_RS01240	COG0205	6-phosphofructokinase activity
D0853_RS01245	COG0534	Mate efflux family protein
D0853_RS01255	COG0459	protein refolding
D0853_RS01270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0853_RS01280	COG1509	lysine 2,3-aminomutase activity
D0853_RS01285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0853_RS01295	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D0853_RS01300	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D0853_RS01305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0853_RS01310	COG1053	succinate dehydrogenase
D0853_RS01320	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D0853_RS01340	COG4942	peptidase
D0853_RS01345	COG1045	serine acetyltransferase
D0853_RS01350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D0853_RS01355	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D0853_RS01360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0853_RS01370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D0853_RS01385	COG0471	metal ion transport
D0853_RS01390	COG0688	phosphatidylethanolamine metabolic process
D0853_RS01395	COG1162	GTPase activity
D0853_RS01400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D0853_RS01480	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D0853_RS01485	COG0802	atpase or kinase
D0853_RS01490	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0853_RS01495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D0853_RS01500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D0853_RS01510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0853_RS01515	COG0330	HflC and HflK could
D0853_RS01520	COG0330	HflC and HflK could
D0853_RS01525	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D0853_RS01530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0853_RS01540	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D0853_RS01545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0853_RS01545	COG1017	nitric oxide dioxygenase activity
D0853_RS01550	COG1959	2 iron, 2 sulfur cluster binding
D0853_RS01555	COG0557	exoribonuclease II activity
D0853_RS01560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0853_RS01565	COG0546	phosphoglycolate phosphatase activity
D0853_RS01570	COG0180	Tryptophanyl-tRNA synthetase
D0853_RS01600	COG0512	Glutamine amidotransferase of anthranilate synthase
D0853_RS01605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0853_RS01615	COG1012	belongs to the aldehyde dehydrogenase family
D0853_RS01625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0853_RS01630	COG3954	Phosphoribulokinase
D0853_RS01635	COG3089	Belongs to the UPF0270 family
D0853_RS01640	COG0429	hydrolase of the alpha beta-hydrolase fold
D0853_RS01650	COG0488	(ABC) transporter
D0853_RS01660	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0853_RS01675	COG1047	Peptidyl-prolyl cis-trans
D0853_RS01685	COG1446	asparaginase
D0853_RS01690	COG2900	Belongs to the SlyX family
D0853_RS01700	COG0545	Peptidyl-prolyl cis-trans isomerase
D0853_RS01705	COG2964	Protein conserved in bacteria
D0853_RS01710	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D0853_RS01715	COG2923	Belongs to the DsrF TusC family
D0853_RS01720	COG2168	tRNA wobble position uridine thiolation
D0853_RS01730	COG0049	tRNA binding
D0853_RS01735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0853_RS01740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0853_RS01745	COG2906	2 iron, 2 sulfur cluster binding
D0853_RS01755	COG0281	malic enzyme
D0853_RS01765	COG0626	cystathionine gamma-synthase activity
D0853_RS01770	COG0460	homoserine dehydrogenase
D0853_RS01770	COG0527	aspartate kinase activity
D0853_RS01775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0853_RS01785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D0853_RS01790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0853_RS01795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0853_RS01800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0853_RS01805	COG0137	argininosuccinate synthase activity
D0853_RS01810	COG0165	Argininosuccinate lyase
D0853_RS01810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0853_RS01825	COG0678	peroxiredoxin activity
D0853_RS01825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0853_RS01835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D0853_RS01865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D0853_RS01870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D0853_RS01880	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D0853_RS01885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0853_RS01890	COG0360	Binds together with S18 to 16S ribosomal RNA
D0853_RS01895	COG2965	DNA replication, synthesis of RNA primer
D0853_RS01905	COG0359	binds to the 23S rRNA
D0853_RS01920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0853_RS01930	COG0432	Pfam Uncharacterised protein family UPF0047
D0853_RS01935	COG0166	Belongs to the GPI family
D0853_RS01945	COG0735	belongs to the Fur family
D0853_RS01955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0853_RS01980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0853_RS01985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0853_RS01990	COG0175	sulfate reduction
D0853_RS02075	COG1410	methionine synthase
D0853_RS02075	COG0646	methionine synthase
D0853_RS02080	COG0527	aspartate kinase activity
D0853_RS02090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0853_RS02100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0853_RS02115	COG0629	single-stranded DNA binding
D0853_RS02120	COG2200	EAL domain
D0853_RS02120	COG2199	diguanylate cyclase activity
D0853_RS02145	COG3409	Peptidoglycan-binding domain 1 protein
D0853_RS02145	COG3267	Type II secretory pathway component ExeA
D0853_RS02155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0853_RS02160	COG1459	type II secretion system
D0853_RS02170	COG2165	general secretion pathway protein
D0853_RS02205	COG1077	Cell shape determining protein MreB Mrl
D0853_RS02210	COG1792	Involved in formation and maintenance of cell shape
D0853_RS02215	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D0853_RS02220	COG0424	maF-like protein
D0853_RS02230	COG3164	Protein of unknown function
D0853_RS02235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0853_RS02240	COG0312	modulator of DNA gyrase
D0853_RS02245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D0853_RS02250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0853_RS02265	COG0564	pseudouridine synthase activity
D0853_RS02270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0853_RS02275	COG3028	Belongs to the UPF0307 family
D0853_RS02280	COG0312	modulator of DNA gyrase
D0853_RS02285	COG2239	Acts as a magnesium transporter
D0853_RS02290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_RS02295	COG1660	Displays ATPase and GTPase activities
D0853_RS02300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_RS02305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0853_RS02315	COG1137	ATPase activity
D0853_RS02320	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D0853_RS02330	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D0853_RS02330	COG0517	IMP dehydrogenase activity
D0853_RS02340	COG1127	ABC transporter
D0853_RS02345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0853_RS02350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0853_RS02355	COG2854	intermembrane phospholipid transfer
D0853_RS02365	COG5007	Belongs to the BolA IbaG family
D0853_RS02370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0853_RS02375	COG0204	Acyl-transferase
D0853_RS02380	COG0251	oxidation-reduction process
D0853_RS02385	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D0853_RS02390	COG0540	Belongs to the ATCase OTCase family
D0853_RS02400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D0853_RS02405	COG2235	arginine
D0853_RS02435	COG0525	valine-tRNA ligase activity
D0853_RS02440	COG2927	DNA polymerase III (CHI subunit)
D0853_RS02445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D0853_RS02450	COG0795	lipopolysaccharide-transporting ATPase activity
D0853_RS02455	COG0795	lipopolysaccharide-transporting ATPase activity
D0853_RS02470	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS02480	COG0726	polysaccharide deacetylase
D0853_RS02485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0853_RS02490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0853_RS02495	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0853_RS02500	COG1486	melibiose metabolic process
D0853_RS02505	COG3394	polysaccharide catabolic process
D0853_RS02515	COG3437	response regulator, receiver
D0853_RS02565	COG1012	belongs to the aldehyde dehydrogenase family
D0853_RS02635	COG0741	lytic transglycosylase activity
D0853_RS02640	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D0853_RS02650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D0853_RS02660	COG2066	Belongs to the glutaminase family
D0853_RS02665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0853_RS02670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D0853_RS02680	COG1872	DUF167
D0853_RS02685	COG0762	integral membrane protein
D0853_RS02690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0853_RS02695	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D0853_RS02710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0853_RS02715	COG1678	Uncharacterized ACR, COG1678
D0853_RS02720	COG0189	ligase activity
D0853_RS02725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0853_RS02730	COG2356	endonuclease I
D0853_RS02735	COG3091	SprT-like family
D0853_RS02745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0853_RS02755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0853_RS02760	COG0583	DNA-binding transcription factor activity
D0853_RS02765	COG4771	TonB-dependent receptor
D0853_RS02770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0853_RS02775	COG0126	phosphoglycerate kinase activity
D0853_RS02780	COG0191	fructose-bisphosphate aldolase activity
D0853_RS02785	COG0668	transmembrane transport
D0853_RS02790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0853_RS02800	COG0583	DNA-binding transcription factor activity
D0853_RS02810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0853_RS02815	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D0853_RS02820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0853_RS02830	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D0853_RS02840	COG3079	Belongs to the UPF0149 family
D0853_RS02845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0853_RS02850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0853_RS02865	COG0354	folic acid binding
D0853_RS02870	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D0853_RS02880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0853_RS02890	COG1595	DNA-templated transcription, initiation
D0853_RS02895	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D0853_RS02905	COG3086	response to oxidative stress
D0853_RS02910	COG0481	GTPase activity
D0853_RS02920	COG0571	ribonuclease III activity
D0853_RS02925	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0853_RS02930	COG1381	Involved in DNA repair and RecF pathway recombination
D0853_RS02935	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D0853_RS02940	COG0736	holo-[acyl-carrier-protein] synthase activity
D0853_RS02955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0853_RS02965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0853_RS02970	COG3956	TIGRFAM MazG family protein
D0853_RS02975	COG0504	CTP synthase activity
D0853_RS02980	COG0148	phosphopyruvate hydratase activity
D0853_RS02985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D0853_RS02990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0853_RS02995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D0853_RS03000	COG0585	pseudouridine synthase activity
D0853_RS03005	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D0853_RS03010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D0853_RS03025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D0853_RS03030	COG1546	Belongs to the CinA family
D0853_RS03035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D0853_RS03040	COG2137	regulation of response to DNA damage stimulus
D0853_RS03045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0853_RS03050	COG0527	aspartate kinase activity
D0853_RS03110	COG3630	sodium ion export across plasma membrane
D0853_RS03115	COG5016	pyruvate
D0853_RS03115	COG0511	ligase activity, forming carbon-carbon bonds
D0853_RS03120	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D0853_RS03130	COG1238	metal cluster binding
D0853_RS03135	COG0612	Peptidase, M16
D0853_RS03140	COG2918	glutathione biosynthetic process
D0853_RS03150	COG1854	S-ribosylhomocysteine lyase activity
D0853_RS03155	COG4536	flavin adenine dinucleotide binding
D0853_RS03160	COG4137	Cytochrome C assembly protein
D0853_RS03165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0853_RS03170	COG0228	four-way junction DNA binding
D0853_RS03175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D0853_RS03180	COG0336	Belongs to the RNA methyltransferase TrmD family
D0853_RS03185	COG0335	large ribosomal subunit rRNA binding
D0853_RS03190	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D0853_RS03195	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D0853_RS03200	COG0237	dephospho-CoA kinase activity
D0853_RS03210	COG1459	type II secretion system
D0853_RS03215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0853_RS03225	COG0157	Belongs to the NadC ModD family
D0853_RS03235	COG2186	Transcriptional regulator
D0853_RS03240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0853_RS03245	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0853_RS03250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0853_RS03265	COG0288	reversible hydration of carbon dioxide
D0853_RS03270	COG0659	secondary active sulfate transmembrane transporter activity
D0853_RS03280	COG1131	(ABC) transporter
D0853_RS03285	COG0842	Transport permease protein
D0853_RS03295	COG1560	Kdo2-lipid A biosynthetic process
D0853_RS03305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D0853_RS03310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D0853_RS03315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0853_RS03330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0853_RS03345	COG1489	DNA binding
D0853_RS03350	COG1643	Atp-dependent helicase
D0853_RS03355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0853_RS03360	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0853_RS03365	COG1049	propionate catabolic process, 2-methylcitrate cycle
D0853_RS03370	COG3112	Uncharacterised protein family (UPF0231)
D0853_RS03380	COG0004	ammonium transporteR
D0853_RS03385	COG1840	ABC-type Fe3 transport system, periplasmic component
D0853_RS03395	COG3842	ATPase activity
D0853_RS03400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0853_RS03415	COG2971	BadF BadG BcrA BcrD
D0853_RS03425	COG4608	Belongs to the ABC transporter superfamily
D0853_RS03430	COG0444	Belongs to the ABC transporter superfamily
D0853_RS03435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0853_RS03445	COG0747	negative chemotaxis
D0853_RS03450	COG0784	Response regulator, receiver
D0853_RS03450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_RS03450	COG2198	Histidine kinase
D0853_RS03450	COG2205	protein histidine kinase activity
D0853_RS03460	COG2813	Specifically methylates the guanine in position
D0853_RS03465	COG0628	permease
D0853_RS03470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0853_RS03475	COG0316	Belongs to the HesB IscA family
D0853_RS03485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_RS03490	COG0739	heme binding
D0853_RS03495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0853_RS03505	COG2027	D-alanyl-D-alanine carboxypeptidase
D0853_RS03510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0853_RS03515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0853_RS03520	COG1534	Rna-binding protein
D0853_RS03525	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D0853_RS03530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0853_RS03535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D0853_RS03540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0853_RS03550	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0853_RS03565	COG0779	Required for maturation of 30S ribosomal subunits
D0853_RS03570	COG0195	Participates in both transcription termination and antitermination
D0853_RS03575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D0853_RS03580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D0853_RS03585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D0853_RS03590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D0853_RS03595	COG1185	polyribonucleotide nucleotidyltransferase activity
D0853_RS03610	COG0534	Mate efflux family protein
D0853_RS03615	COG0826	peptidase U32
D0853_RS03620	COG0826	peptidase U32
D0853_RS03630	COG3154	lipid carrier protein
D0853_RS03635	COG3153	acetyltransferase
D0853_RS03655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D0853_RS03665	COG0084	hydrolase, TatD family'
D0853_RS03670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0853_RS03675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D0853_RS03680	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D0853_RS03685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D0853_RS03690	COG0813	purine-nucleoside phosphorylase activity
D0853_RS03700	COG0560	Phosphoserine phosphatase
D0853_RS03710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D0853_RS03715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0853_RS03720	COG0583	DNA-binding transcription factor activity
D0853_RS03730	COG1022	Amp-dependent synthetase and ligase
D0853_RS03735	COG2169	Transcriptional regulator
D0853_RS03760	COG4964	Belongs to the GSP D family
D0853_RS03820	COG0583	DNA-binding transcription factor activity
D0853_RS03825	COG0531	amino acid
D0853_RS03830	COG2731	YhcH YjgK YiaL family protein
D0853_RS03835	COG3250	beta-galactosidase activity
D0853_RS03840	COG1609	Transcriptional regulator
D0853_RS03850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0853_RS03860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D0853_RS03865	COG2017	converts alpha-aldose to the beta-anomer
D0853_RS03870	COG1609	Transcriptional regulator
D0853_RS03880	COG2211	Major facilitator Superfamily
D0853_RS03885	COG1609	Transcriptional regulator
D0853_RS03890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0853_RS03905	COG0598	Magnesium transport protein CorA
D0853_RS03910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0853_RS03915	COG1349	DNA-binding transcription factor activity
D0853_RS03920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0853_RS03925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0853_RS03940	COG2271	Major facilitator Superfamily
D0853_RS03945	COG0584	glycerophosphoryl diester phosphodiesterase
D0853_RS03950	COG2171	N-acyltransferase activity
D0853_RS03955	COG3141	response to X-ray
D0853_RS03975	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D0853_RS03985	COG1074	ATP-dependent DNA helicase activity
D0853_RS03990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0853_RS04000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0853_RS04000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0853_RS04015	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D0853_RS04020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0853_RS04025	COG2166	iron-sulfur cluster assembly
D0853_RS04030	COG3706	GGDEF domain
D0853_RS04035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0853_RS04040	COG0693	protein deglycase activity
D0853_RS04045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0853_RS04050	COG3248	Nucleoside-binding outer membrane protein
D0853_RS04075	COG1595	DNA-templated transcription, initiation
D0853_RS04095	COG3056	Lipoprotein
D0853_RS04100	COG2813	Specifically methylates the guanine in position
D0853_RS04105	COG0271	Belongs to the BolA IbaG family
D0853_RS04110	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0853_RS04115	COG1805	sodium ion transport
D0853_RS04120	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0853_RS04125	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0853_RS04130	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0853_RS04135	COG2871	sodium ion transport
D0853_RS04140	COG1477	protein flavinylation
D0853_RS04155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0853_RS04160	COG0514	ATP-dependent DNA helicase (RecQ)
D0853_RS04165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0853_RS04180	COG0733	neurotransmitter:sodium symporter activity
D0853_RS04200	COG0442	prolyl-tRNA aminoacylation
D0853_RS04205	COG1720	tRNA m6t6A37 methyltransferase activity
D0853_RS04210	COG0254	rRNA binding
D0853_RS04225	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0853_RS04230	COG1671	Belongs to the UPF0178 family
D0853_RS04255	COG3098	single-species biofilm formation
D0853_RS04260	COG0564	pseudouridine synthase activity
D0853_RS04270	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D0853_RS04275	COG0024	Methionine aminopeptidase
D0853_RS04280	COG0052	Belongs to the universal ribosomal protein uS2 family
D0853_RS04285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D0853_RS04290	COG0528	UMP kinase activity
D0853_RS04295	COG0233	cytoplasmic translational termination
D0853_RS04300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0853_RS04305	COG0575	Belongs to the CDS family
D0853_RS04310	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D0853_RS04315	COG0750	zinc metalloprotease
D0853_RS04325	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D0853_RS04330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0853_RS04335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0853_RS04340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0853_RS04345	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0853_RS04350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D0853_RS04355	COG0587	DNA-directed DNA polymerase activity
D0853_RS04360	COG0825	malonyl-CoA metabolic process
D0853_RS04365	COG0037	tRNA processing
D0853_RS04375	COG0347	Belongs to the P(II) protein family
D0853_RS04380	COG3021	interspecies interaction between organisms
D0853_RS04390	COG0741	lytic transglycosylase activity
D0853_RS04390	COG1388	LysM domain
D0853_RS04395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0853_RS04400	COG2226	methyltransferase
D0853_RS04405	COG0328	RNA-DNA hybrid ribonuclease activity
D0853_RS04410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0853_RS04425	COG1960	acyl-CoA dehydrogenase activity
D0853_RS04430	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D0853_RS04435	COG0121	glutamine amidotransferase
D0853_RS04440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0853_RS04445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D0853_RS04450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0853_RS04455	COG2233	PERMEase
D0853_RS04475	COG1393	Belongs to the ArsC family
D0853_RS04480	COG4783	chaperone-mediated protein folding
D0853_RS04495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D0853_RS04500	COG2716	regulation of RNA biosynthetic process
D0853_RS04505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0853_RS04510	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D0853_RS04525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0853_RS04530	COG1393	Belongs to the ArsC family
D0853_RS04560	COG2837	iron assimilation
D0853_RS04565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_RS04575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_RS04580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_RS04585	COG1334	flagellar protein FlaG
D0853_RS04590	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D0853_RS04600	COG1516	flagellar protein fliS
D0853_RS04620	COG1677	Flagellar hook-basal body complex protein FliE
D0853_RS04630	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0853_RS04680	COG1987	bacterial-type flagellum assembly
D0853_RS04685	COG1684	flagellar biosynthetic protein fliR
D0853_RS04720	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D0853_RS04725	COG2198	Histidine kinase
D0853_RS04725	COG0643	Histidine kinase
D0853_RS04725	COG0784	Response regulator, receiver
D0853_RS04730	COG2201	protein-glutamate methylesterase activity
D0853_RS04735	COG1192	Involved in chromosome partitioning
D0853_RS04745	COG0835	chemotaxis
D0853_RS04755	COG4133	protoheme IX ABC transporter activity
D0853_RS04760	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0853_RS04765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0853_RS04770	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0853_RS04775	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D0853_RS04780	COG1138	Cytochrome C-type biogenesis protein
D0853_RS04785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0853_RS04800	COG2853	Lipoprotein
D0853_RS04810	COG2067	long-chain fatty acid transport protein
D0853_RS04830	COG0183	Belongs to the thiolase family
D0853_RS04835	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0853_RS04835	COG1024	Enoyl-CoA hydratase
D0853_RS04850	COG2062	phosphohistidine phosphatase, SixA
D0853_RS04855	COG2840	Smr protein MutS2
D0853_RS04860	COG2890	protein-(glutamine-N5) methyltransferase activity
D0853_RS04865	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D0853_RS04870	COG2860	membrane
D0853_RS04880	COG3101	peptidyl-lysine hydroxylation
D0853_RS04895	COG0431	NADPH-dependent FMN reductase
D0853_RS04900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0853_RS04900	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D0853_RS04905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0853_RS04915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0853_RS04920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0853_RS04930	COG0101	tRNA pseudouridine synthase activity
D0853_RS04935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D0853_RS04940	COG0285	dihydrofolate synthase activity
D0853_RS04945	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D0853_RS04950	COG1286	toxin biosynthetic process
D0853_RS04955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D0853_RS04960	COG0583	DNA-binding transcription factor activity
D0853_RS04965	COG0745	RESPONSE REGULATOR receiver
D0853_RS04975	COG2832	Protein of unknown function (DUF454)
D0853_RS04980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0853_RS04990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D0853_RS04995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0853_RS05000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0853_RS05005	COG0814	amino acid
D0853_RS05010	COG0251	oxidation-reduction process
D0853_RS05015	COG3681	Belongs to the UPF0597 family
D0853_RS05030	COG2261	transglycosylase associated protein
D0853_RS05035	COG2983	Belongs to the UPF0260 family
D0853_RS05040	COG0668	transmembrane transport
D0853_RS05045	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D0853_RS05050	COG0346	lactoylglutathione lyase activity
D0853_RS05060	COG1785	Belongs to the alkaline phosphatase family
D0853_RS05080	COG2226	methyltransferase
D0853_RS05095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0853_RS05100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0853_RS05110	COG3139	Protein of unknown function (DUF1315)
D0853_RS05115	COG0252	asparaginase activity
D0853_RS05120	COG0616	signal peptide processing
D0853_RS05125	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0853_RS05125	COG1902	pentaerythritol trinitrate reductase activity
D0853_RS05130	COG0778	Nitroreductase
D0853_RS05135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0853_RS05155	COG0123	including yeast histone deacetylase and acetoin utilization protein
D0853_RS05225	COG0582	viral genome integration into host DNA
D0853_RS05235	COG3083	sulfuric ester hydrolase activity
D0853_RS05240	COG3082	Protein of unknown function (DUF1414)
D0853_RS05245	COG3081	Nucleoid-associated protein
D0853_RS05260	COG1757	Na H antiporter
D0853_RS05265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0853_RS05270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0853_RS05275	COG2095	MarC family integral membrane protein
D0853_RS05280	COG1454	alcohol dehydrogenase
D0853_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
D0853_RS05300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D0853_RS05310	COG2056	Na+-H+ antiporter family
D0853_RS05315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0853_RS05330	COG2885	chlorophyll binding
D0853_RS05340	COG0346	lactoylglutathione lyase activity
D0853_RS05345	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0853_RS05350	COG4660	Part of a membrane complex involved in electron transport
D0853_RS05355	COG4659	FMN binding
D0853_RS05360	COG4658	electron transport chain
D0853_RS05365	COG4656	Part of a membrane complex involved in electron transport
D0853_RS05370	COG2878	Part of a membrane complex involved in electron transport
D0853_RS05375	COG4657	Part of a membrane complex involved in electron transport
D0853_RS05390	COG0556	nucleotide-excision repair
D0853_RS05395	COG2204	response regulator
D0853_RS05400	COG2198	Histidine kinase
D0853_RS05405	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D0853_RS05410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D0853_RS05415	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0853_RS05420	COG0315	cyclic pyranopterin monophosphate synthase activity
D0853_RS05425	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D0853_RS05430	COG0314	molybdopterin synthase activity
D0853_RS05440	COG0601	transmembrane transport
D0853_RS05445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0853_RS05450	COG0444	Belongs to the ABC transporter superfamily
D0853_RS05460	COG0435	Glutathione S-transferase
D0853_RS05470	COG3174	membrane
D0853_RS05475	COG0857	belongs to the CobB CobQ family
D0853_RS05475	COG0280	phosphate acetyltransferase
D0853_RS05480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0853_RS05485	COG3092	negative regulation of chromosome organization
D0853_RS05495	COG4120	Belongs to the binding-protein-dependent transport system permease family
D0853_RS05500	COG1122	ATPase activity
D0853_RS05505	COG0366	Alpha amylase catalytic
D0853_RS05515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0853_RS05520	COG0653	protein targeting
D0853_RS05525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D0853_RS05530	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D0853_RS05535	COG2186	Transcriptional regulator
D0853_RS05545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0853_RS05545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0853_RS05550	COG0489	protein tyrosine kinase activity
D0853_RS05555	COG0572	uridine kinase
D0853_RS05565	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D0853_RS05570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0853_RS05575	COG0659	secondary active sulfate transmembrane transporter activity
D0853_RS05585	COG1530	ribonuclease E activity
D0853_RS05600	COG0564	pseudouridine synthase activity
D0853_RS05605	COG0424	maF-like protein
D0853_RS05610	COG1399	metal-binding, possibly nucleic acid-binding protein
D0853_RS05620	COG0416	fatty acid biosynthetic process
D0853_RS05625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0853_RS05655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0853_RS05660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0853_RS05670	COG0084	hydrolase, TatD family'
D0853_RS05675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0853_RS05675	COG1263	PTS System
D0853_RS05695	COG0733	neurotransmitter:sodium symporter activity
D0853_RS05710	COG4667	esterase of the alpha-beta hydrolase superfamily
D0853_RS05715	COG0469	pyruvate kinase activity
D0853_RS05720	COG1940	carbohydrate kinase activity
D0853_RS05725	COG0784	Response regulator, receiver
D0853_RS05725	COG0835	chemotaxis
D0853_RS05730	COG0587	DNA-directed DNA polymerase activity
D0853_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS05750	COG0616	signal peptide processing
D0853_RS05755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0853_RS05760	COG0539	negative regulation of cytoplasmic translation
D0853_RS05770	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D0853_RS05775	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D0853_RS05780	COG0284	orotidine-5'-phosphate decarboxylase activity
D0853_RS05785	COG4166	transmembrane transport
D0853_RS05810	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0853_RS05820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0853_RS05820	COG3008	intermembrane lipid transfer
D0853_RS05825	COG2995	paraquat-inducible protein a
D0853_RS05830	COG3258	Cytochrome c
D0853_RS05835	COG2863	cytochrome
D0853_RS05875	COG4232	protein-disulfide reductase activity
D0853_RS05880	COG3118	belongs to the thioredoxin family
D0853_RS05910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_RS05920	COG1136	(ABC) transporter
D0853_RS05920	COG0577	efflux transmembrane transporter activity
D0853_RS05925	COG1136	(ABC) transporter
D0853_RS05925	COG0577	efflux transmembrane transporter activity
D0853_RS05930	COG1136	(ABC) transporter
D0853_RS05930	COG0577	efflux transmembrane transporter activity
D0853_RS05935	COG1335	isochorismatase
D0853_RS05940	COG2207	Transcriptional regulator
D0853_RS05940	COG1917	Cupin 2, conserved barrel domain protein
D0853_RS05985	COG5002	protein histidine kinase activity
D0853_RS05985	COG3850	Histidine kinase
D0853_RS05990	COG0745	RESPONSE REGULATOR receiver
D0853_RS06000	COG0840	transmembrane signaling receptor activity
D0853_RS06005	COG1032	radical SAM domain protein
D0853_RS06010	COG3706	GGDEF domain
D0853_RS06010	COG4251	negative regulation of phosphorylation
D0853_RS06010	COG5001	Diguanylate cyclase
D0853_RS06010	COG2203	Gaf domain
D0853_RS06025	COG0583	DNA-binding transcription factor activity
D0853_RS06035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0853_RS06045	COG2350	Protein conserved in bacteria
D0853_RS06055	COG2917	probably involved in intracellular septation
D0853_RS06075	COG1301	dicarboxylic acid transport
D0853_RS06085	COG0318	PFAM AMP-dependent synthetase and ligase
D0853_RS06090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0853_RS06100	COG0159	tryptophan synthase activity
D0853_RS06105	COG0133	tryptophan synthase activity
D0853_RS06110	COG0135	phosphoribosylanthranilate isomerase activity
D0853_RS06110	COG0134	indole-3-glycerol-phosphate synthase activity
D0853_RS06115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0853_RS06120	COG0512	Glutamine amidotransferase of anthranilate synthase
D0853_RS06125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0853_RS06135	COG0613	PHP domain protein
D0853_RS06140	COG0009	L-threonylcarbamoyladenylate synthase
D0853_RS06150	COG1187	pseudouridine synthase activity
D0853_RS06160	COG3099	Belongs to the UPF0263 family
D0853_RS06165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0853_RS06175	COG0417	DNA replication proofreading
D0853_RS06180	COG2197	response regulator
D0853_RS06185	COG0322	excinuclease ABC activity
D0853_RS06225	COG0019	diaminopimelate decarboxylase activity
D0853_RS06250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0853_RS06255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0853_RS06260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0853_RS06280	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D0853_RS06290	COG0437	4 iron, 4 sulfur cluster binding
D0853_RS06295	COG3301	Polysulphide reductase, NrfD
D0853_RS06300	COG1138	Cytochrome C-type biogenesis protein
D0853_RS06310	COG4235	cytochrome complex assembly
D0853_RS06310	COG3088	subunit of a heme lyase
D0853_RS06320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0853_RS06345	COG2989	Protein conserved in bacteria
D0853_RS06350	COG3108	Peptidase M15
D0853_RS06355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0853_RS06370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D0853_RS06395	COG1846	Transcriptional regulator
D0853_RS06400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0853_RS06405	COG0840	transmembrane signaling receptor activity
D0853_RS06425	COG1448	Aminotransferase
D0853_RS06450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0853_RS06460	COG0017	Asparaginyl-tRNA synthetase
D0853_RS06465	COG0840	transmembrane signaling receptor activity
D0853_RS06475	COG0557	exoribonuclease II activity
D0853_RS06480	COG1278	Cold shock
D0853_RS06510	COG0720	synthase
D0853_RS06520	COG2200	EAL domain
D0853_RS06525	COG1760	l-serine dehydratase
D0853_RS06530	COG0814	amino acid
D0853_RS06535	COG0494	nUDIX hydrolase
D0853_RS06545	COG0784	Response regulator, receiver
D0853_RS06545	COG2205	protein histidine kinase activity
D0853_RS06550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0853_RS06570	COG3106	COG3106 Predicted ATPase
D0853_RS06575	COG3768	UPF0283 membrane protein
D0853_RS06585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0853_RS06620	COG0346	lactoylglutathione lyase activity
D0853_RS06885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0853_RS06925	COG2161	toxin-antitoxin pair type II binding
D0853_RS06930	COG4115	mRNA cleavage
D0853_RS07000	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0853_RS07040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0853_RS07125	COG0251	oxidation-reduction process
D0853_RS07190	COG2957	Belongs to the agmatine deiminase family
D0853_RS07195	COG1012	belongs to the aldehyde dehydrogenase family
D0853_RS07200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0853_RS07205	COG1227	inorganic diphosphatase activity
D0853_RS07215	COG2771	luxR family
D0853_RS07215	COG2200	EAL domain
D0853_RS07230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0853_RS07245	COG1846	Transcriptional regulator
D0853_RS07250	COG2315	Protein conserved in bacteria
D0853_RS07270	COG0110	maltose O-acetyltransferase activity
D0853_RS07300	COG3063	Type IV pilus biogenesis stability protein PilW
D0853_RS07305	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D0853_RS07320	COG0531	amino acid
D0853_RS07330	COG1560	Kdo2-lipid A biosynthetic process
D0853_RS07335	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D0853_RS07340	COG1280	lysine exporter protein (LysE YggA)
D0853_RS07350	COG1115	amino acid carrier protein
D0853_RS07375	COG1368	sulfuric ester hydrolase activity
D0853_RS07380	COG0642	Histidine kinase
D0853_RS07385	COG0745	RESPONSE REGULATOR receiver
D0853_RS07395	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS07415	COG2113	Glycine betaine
D0853_RS07420	COG4176	ABC-type proline glycine betaine transport system permease component
D0853_RS07440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0853_RS07445	COG0456	acetyltransferase
D0853_RS07450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0853_RS07455	COG0662	Cupin 2, conserved barrel domain protein
D0853_RS07460	COG0527	aspartate kinase activity
D0853_RS07465	COG1858	cytochrome C peroxidase
D0853_RS07480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_RS07495	COG3290	protein histidine kinase activity
D0853_RS07500	COG4565	transcriptional regulatory protein
D0853_RS07505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D0853_RS07510	COG0363	glucosamine-6-phosphate deaminase activity
D0853_RS07515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0853_RS07540	COG3284	Transcriptional regulator
D0853_RS07545	COG1012	belongs to the aldehyde dehydrogenase family
D0853_RS07615	COG4669	(LipO)protein
D0853_RS07635	COG3177	Filamentation induced by cAMP protein fic
D0853_RS07675	COG1073	alpha beta
D0853_RS07680	COG1073	alpha beta
D0853_RS07690	COG4792	protein secretion
D0853_RS07695	COG4791	protein targeting
D0853_RS07700	COG4794	Type iii secretion
D0853_RS07705	COG4790	Type iii secretion
D0853_RS07775	COG0457	Tetratricopeptide repeat
D0853_RS07795	COG0730	response to heat
D0853_RS07825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D0853_RS07830	COG0372	Belongs to the citrate synthase family
D0853_RS07840	COG2828	Protein conserved in bacteria
D0853_RS07865	COG0561	phosphatase activity
D0853_RS07870	COG0602	queuosine metabolic process
D0853_RS07875	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D0853_RS07880	COG3706	GGDEF domain
D0853_RS07920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D0853_RS07925	COG0840	transmembrane signaling receptor activity
D0853_RS07930	COG1254	Belongs to the acylphosphatase family
D0853_RS07935	COG2920	part of a sulfur-relay system
D0853_RS07945	COG0670	Belongs to the BI1 family
D0853_RS07950	COG1126	abc transporter atp-binding protein
D0853_RS07955	COG0765	amino acid transport
D0853_RS07960	COG4597	amino acid ABC transporter
D0853_RS07965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_RS07985	COG1666	GTP binding
D0853_RS07990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0853_RS08010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0853_RS08010	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D0853_RS08020	COG3008	intermembrane lipid transfer
D0853_RS08025	COG2995	paraquat-inducible protein a
D0853_RS08030	COG1132	(ABC) transporter
D0853_RS08035	COG1956	GAF domain-containing protein
D0853_RS08040	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D0853_RS08055	COG0308	aminopeptidase N
D0853_RS08065	COG2902	Dehydrogenase
D0853_RS08070	COG0167	dihydroorotate dehydrogenase activity
D0853_RS08085	COG0116	Belongs to the methyltransferase superfamily
D0853_RS08085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D0853_RS08095	COG0488	(ABC) transporter
D0853_RS08110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0853_RS08115	COG1067	ATP-dependent peptidase activity
D0853_RS08120	COG3120	sequence-specific DNA binding
D0853_RS08330	COG0784	Response regulator, receiver
D0853_RS08330	COG2205	protein histidine kinase activity
D0853_RS08345	COG3278	Belongs to the heme-copper respiratory oxidase family
D0853_RS08360	COG2010	Cytochrome c
D0853_RS08370	COG2217	Heavy metal translocating P-type atpase
D0853_RS08385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0853_RS08390	COG0589	response to stress
D0853_RS08400	COG0037	tRNA processing
D0853_RS08420	COG3842	ATPase activity
D0853_RS08430	COG1177	transmembrane transport
D0853_RS08440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0853_RS08445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0853_RS08455	COG0004	ammonium transporteR
D0853_RS08500	COG0437	4 iron, 4 sulfur cluster binding
D0853_RS08505	COG3383	formate dehydrogenase (NAD+) activity
D0853_RS08505	COG0243	molybdopterin cofactor binding
D0853_RS08540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D0853_RS08545	COG0488	(ABC) transporter
D0853_RS08555	COG4191	Histidine kinase
D0853_RS08560	COG2204	response regulator
D0853_RS08580	COG3842	ATPase activity
D0853_RS08585	COG0746	molybdenum cofactor guanylyltransferase activity
D0853_RS08590	COG0303	'Molybdopterin
D0853_RS08600	COG1940	carbohydrate kinase activity
D0853_RS08605	COG3148	PFAM DTW domain containing protein
D0853_RS08640	COG3290	protein histidine kinase activity
D0853_RS08640	COG0840	transmembrane signaling receptor activity
D0853_RS08645	COG0791	NLP P60 protein
D0853_RS08655	COG3706	GGDEF domain
D0853_RS08660	COG2201	protein-glutamate methylesterase activity
D0853_RS08665	COG3001	Fructosamine kinase
D0853_RS08675	COG0307	riboflavin synthase, alpha
D0853_RS08680	COG0534	Mate efflux family protein
D0853_RS08690	COG1793	dna ligase
D0853_RS08725	COG2204	response regulator
D0853_RS08735	COG0438	transferase activity, transferring glycosyl groups
D0853_RS08770	COG0438	transferase activity, transferring glycosyl groups
D0853_RS08775	COG1215	transferase activity, transferring glycosyl groups
D0853_RS08780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0853_RS08790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0853_RS08805	COG1643	Atp-dependent helicase
D0853_RS08810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D0853_RS08825	COG3302	dmso reductase anchor subunit
D0853_RS08830	COG0437	4 iron, 4 sulfur cluster binding
D0853_RS08835	COG0243	molybdopterin cofactor binding
D0853_RS08865	COG3706	GGDEF domain
D0853_RS08875	COG0443	Heat shock 70 kDa protein
D0853_RS08880	COG0443	Heat shock 70 kDa protein
D0853_RS08910	COG1132	(ABC) transporter
D0853_RS08915	COG1132	(ABC) transporter
D0853_RS08940	COG0814	amino acid
D0853_RS08955	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0853_RS09035	COG1522	sequence-specific DNA binding
D0853_RS09070	COG0515	serine threonine protein kinase
D0853_RS09095	COG3501	Rhs element vgr protein
D0853_RS09110	COG2204	response regulator
D0853_RS09135	COG0739	heme binding
D0853_RS09145	COG0861	Integral membrane protein TerC family
D0853_RS09155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0853_RS09160	COG1328	CTP reductase activity
D0853_RS09165	COG1280	lysine exporter protein (LysE YggA)
D0853_RS09175	COG5001	Diguanylate cyclase
D0853_RS09175	COG3300	MHYT domain
D0853_RS09185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_RS09185	COG4191	Histidine kinase
D0853_RS09190	COG0471	metal ion transport
D0853_RS09225	COG0583	DNA-binding transcription factor activity
D0853_RS09230	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D0853_RS09235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0853_RS09240	COG1511	domain protein
D0853_RS09240	COG3264	Mechanosensitive ion channel
D0853_RS09255	COG1127	ABC transporter
D0853_RS09260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0853_RS09320	COG0625	glutathione transferase activity
D0853_RS09330	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D0853_RS09345	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0853_RS09355	COG0601	transmembrane transport
D0853_RS09360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0853_RS09365	COG0444	Belongs to the ABC transporter superfamily
D0853_RS09385	COG3291	Pkd domain containing protein
D0853_RS09400	COG1177	transmembrane transport
D0853_RS09405	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0853_RS09410	COG3842	ATPase activity
D0853_RS09415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0853_RS09420	COG2423	ornithine cyclodeaminase activity
D0853_RS09440	COG3938	Belongs to the proline racemase family
D0853_RS09470	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D0853_RS09475	COG1451	nucleotide metabolic process
D0853_RS09480	COG3475	LICD family
D0853_RS09485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0853_RS09490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0853_RS09510	COG0583	DNA-binding transcription factor activity
D0853_RS09530	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
D0853_RS09535	COG4139	cobalamin transport
D0853_RS09540	COG2988	succinylglutamate desuccinylase activity
D0853_RS09565	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D0853_RS09570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D0853_RS09575	COG0702	epimerase
D0853_RS09580	COG1823	symporter activity
D0853_RS09585	COG2925	Exonuclease
D0853_RS09590	COG1380	Effector of murein hydrolase LrgA
D0853_RS09595	COG1346	cytolysis
D0853_RS09600	COG0295	cytidine deaminase activity
D0853_RS09605	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D0853_RS09610	COG0500	methyltransferase
D0853_RS09620	COG0776	regulation of translation
D0853_RS09635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0853_RS09635	COG0072	phenylalanine-tRNA ligase activity
D0853_RS09640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D0853_RS09645	COG3706	GGDEF domain
D0853_RS09675	COG0393	Putative heavy-metal-binding
D0853_RS09685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D0853_RS09695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D0853_RS09710	COG2188	Transcriptional regulator
D0853_RS09715	COG1228	amidohydrolase
D0853_RS09720	COG0010	Belongs to the arginase family
D0853_RS09725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D0853_RS09730	COG2986	histidine ammonia-lyase
D0853_RS09745	COG0277	FAD linked oxidase domain protein
D0853_RS09745	COG0247	lactate metabolic process
D0853_RS09780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D0853_RS09795	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
D0853_RS09805	COG0281	malic enzyme
D0853_RS09810	COG2949	membrane
D0853_RS09815	COG0471	metal ion transport
D0853_RS09840	COG0492	ferredoxin-NADP+ reductase activity
D0853_RS09845	COG4988	ABC transporter
D0853_RS09850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D0853_RS09855	COG3048	D-serine ammonia-lyase activity
D0853_RS09860	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0853_RS09870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_RS09870	COG4191	Histidine kinase
D0853_RS09885	COG3070	regulator of competence-specific genes
D0853_RS09905	COG2431	L-lysine efflux transmembrane transporter activity
D0853_RS09915	COG0076	glutamate decarboxylase activity
D0853_RS09920	COG1737	Transcriptional regulator
D0853_RS09935	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0853_RS09940	COG3273	potassium ion transport
D0853_RS09940	COG2985	domain, Protein
D0853_RS09945	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0853_RS09960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D0853_RS09975	COG4181	ATPase activity
D0853_RS09980	COG0534	Mate efflux family protein
D0853_RS09985	COG0702	epimerase
D0853_RS09990	COG3005	denitrification pathway
D0853_RS10020	COG2814	Major facilitator Superfamily
D0853_RS10025	COG1187	pseudouridine synthase activity
D0853_RS10030	COG1061	Type III restriction enzyme res subunit
D0853_RS10050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D0853_RS10080	COG3313	Fe-S protein
D0853_RS10105	COG0493	'glutamate synthase
D0853_RS10115	COG0398	Pfam SNARE associated Golgi protein
D0853_RS10120	COG4134	Bacterial extracellular solute-binding protein
D0853_RS10125	COG4135	transport system, permease component
D0853_RS10130	COG4136	ATPase activity
D0853_RS10135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0853_RS10150	COG3604	Transcriptional regulator
D0853_RS10155	COG1151	hydroxylamine reductase activity
D0853_RS10160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0853_RS10170	COG0564	pseudouridine synthase activity
D0853_RS10180	COG0733	neurotransmitter:sodium symporter activity
D0853_RS10190	COG0626	cystathionine gamma-synthase activity
D0853_RS10195	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D0853_RS10200	COG5380	lipid catabolic process
D0853_RS10205	COG2818	Glycosylase
D0853_RS10220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_RS10225	COG1983	PspC domain protein
D0853_RS10235	COG1842	Phage shock protein A
D0853_RS10240	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0853_RS10255	COG4171	peptide transport system, permease
D0853_RS10265	COG4172	Belongs to the ABC transporter superfamily
D0853_RS10275	COG1227	inorganic diphosphatase activity
D0853_RS10290	COG0243	molybdopterin cofactor binding
D0853_RS10295	COG3005	denitrification pathway
D0853_RS10300	COG4459	periplasmic nitrate reductase
D0853_RS10305	COG0390	transport system, permease component
D0853_RS10315	COG2116	formate transmembrane transporter activity
D0853_RS10340	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0853_RS10345	COG1435	thymidine kinase activity
D0853_RS10350	COG0215	cysteine-tRNA ligase activity
D0853_RS10355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0853_RS10360	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0853_RS10365	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D0853_RS10375	COG3012	SEC-C Motif Domain Protein
D0853_RS10380	COG0140	phosphoribosyl-ATP diphosphatase activity
D0853_RS10380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0853_RS10385	COG0107	imidazoleglycerol-phosphate synthase activity
D0853_RS10390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D0853_RS10395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0853_RS10400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0853_RS10400	COG0131	Imidazoleglycerol-phosphate dehydratase
D0853_RS10405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0853_RS10410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0853_RS10415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D0853_RS10430	COG1757	Na H antiporter
D0853_RS10440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0853_RS10450	COG0482	sulfurtransferase activity
D0853_RS10455	COG2915	High frequency lysogenization protein hflD homolog
D0853_RS10460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0853_RS10485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0853_RS10500	COG0300	oxidoreductase activity
D0853_RS10510	COG0501	Belongs to the peptidase M48B family
D0853_RS10520	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D0853_RS10530	COG0156	8-amino-7-oxononanoate synthase activity
D0853_RS10535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D0853_RS10545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0853_RS10560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0853_RS10565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0853_RS10570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D0853_RS10575	COG1674	ftsk spoiiie
D0853_RS10585	COG0686	Belongs to the AlaDH PNT family
D0853_RS10595	COG0583	DNA-binding transcription factor activity
D0853_RS10610	COG3568	Endonuclease Exonuclease Phosphatase
D0853_RS10640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_RS10645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_RS10660	COG0840	transmembrane signaling receptor activity
D0853_RS10675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0853_RS10720	COG0582	viral genome integration into host DNA
D0853_RS10765	COG5002	protein histidine kinase activity
D0853_RS10765	COG0784	Response regulator, receiver
D0853_RS10775	COG0754	glutathionylspermidine amidase activity
D0853_RS10785	COG3766	membrane
D0853_RS10795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D0853_RS10800	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D0853_RS10805	COG2885	chlorophyll binding
D0853_RS10810	COG0823	Involved in the tonB-independent uptake of proteins
D0853_RS10825	COG0811	peptide transport
D0853_RS10830	COG0824	Thioesterase
D0853_RS10840	COG4890	Cyd operon protein YbgT
D0853_RS10845	COG1294	oxidase, subunit
D0853_RS10850	COG1271	oxidase subunit
D0853_RS10855	COG2255	four-way junction helicase activity
D0853_RS10860	COG0632	four-way junction helicase activity
D0853_RS10865	COG0840	transmembrane signaling receptor activity
D0853_RS10870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D0853_RS10875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D0853_RS10880	COG1801	Protein of unknown function DUF72
D0853_RS10885	COG4106	trans-aconitate 2-methyltransferase activity
D0853_RS10890	COG0500	methyltransferase
D0853_RS10900	COG4067	protein conserved in archaea
D0853_RS10900	COG0189	ligase activity
D0853_RS10920	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D0853_RS10925	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D0853_RS10930	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D0853_RS10935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0853_RS10940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0853_RS10945	COG0745	RESPONSE REGULATOR receiver
D0853_RS10950	COG3381	protein complex oligomerization
D0853_RS10955	COG1609	Transcriptional regulator
D0853_RS10960	COG3070	regulator of competence-specific genes
D0853_RS10980	COG0297	glycogen (starch) synthase activity
D0853_RS10985	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0853_RS10990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0853_RS11000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D0853_RS11010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D0853_RS11015	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D0853_RS11020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D0853_RS11030	COG0542	response to heat
D0853_RS11035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D0853_RS11040	COG1278	Cold shock
D0853_RS11050	COG1187	pseudouridine synthase activity
D0853_RS11055	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0853_RS11065	COG1199	ATP-dependent helicase activity
D0853_RS11070	COG0730	response to heat
D0853_RS11075	COG3923	Primosomal replication protein n
D0853_RS11085	COG0708	Exodeoxyribonuclease III
D0853_RS11130	COG1882	Formate acetyltransferase
D0853_RS11140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0853_RS11150	COG3013	Belongs to the UPF0304 family
D0853_RS11160	COG2766	serine protein kinase
D0853_RS11165	COG2718	Belongs to the UPF0229 family
D0853_RS11170	COG2719	SpoVR family
D0853_RS11175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D0853_RS11185	COG1663	tetraacyldisaccharide 4'-kinase activity
D0853_RS11190	COG1132	(ABC) transporter
D0853_RS11195	COG2333	competence protein COMEC
D0853_RS11195	COG0658	competence protein
D0853_RS11205	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0853_RS11210	COG1136	(ABC) transporter
D0853_RS11215	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0853_RS11225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0853_RS11245	COG1252	NADH dehydrogenase
D0853_RS11255	COG3150	esterase
D0853_RS11280	COG0537	adenosine 5'-monophosphoramidase activity
D0853_RS11310	COG0516	GMP reductase activity
D0853_RS11310	COG0517	IMP dehydrogenase activity
D0853_RS11320	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D0853_RS11325	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D0853_RS11330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0853_RS11340	COG2199	diguanylate cyclase activity
D0853_RS11355	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D0853_RS11360	COG1946	Acyl-CoA thioesterase
D0853_RS11370	COG1522	sequence-specific DNA binding
D0853_RS11400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_RS11450	COG0477	Major facilitator Superfamily
D0853_RS11455	COG2855	membrane
D0853_RS11475	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D0853_RS11480	COG0596	Alpha beta hydrolase
D0853_RS11485	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D0853_RS11490	COG1169	isochorismate synthase
D0853_RS11495	COG0436	Aminotransferase
D0853_RS11500	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D0853_RS11505	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D0853_RS11520	COG1555	photosystem II stabilization
D0853_RS11525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0853_RS11530	COG0776	regulation of translation
D0853_RS11535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0853_RS11540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D0853_RS11550	COG0544	peptidyl-prolyl cis-trans isomerase activity
D0853_RS11560	COG2204	response regulator
D0853_RS11570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0853_RS11575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0853_RS11580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0853_RS11585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D0853_RS11605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0853_RS11610	COG0569	domain protein
D0853_RS11615	COG0513	Belongs to the DEAD box helicase family
D0853_RS11620	COG1253	flavin adenine dinucleotide binding
D0853_RS11655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0853_RS11660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0853_RS11675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0853_RS11680	COG1216	Glycosyl transferase, family 2
D0853_RS11685	COG2986	histidine ammonia-lyase
D0853_RS11710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0853_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS11725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0853_RS11740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D0853_RS11745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0853_RS11750	COG0583	DNA-binding transcription factor activity
D0853_RS11755	COG2951	lytic endotransglycosylase activity
D0853_RS11760	COG3100	YcgL domain-containing protein
D0853_RS11765	COG0850	regulation of cytokinetic process
D0853_RS11770	COG2894	cell division
D0853_RS11775	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D0853_RS11780	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D0853_RS11785	COG0318	PFAM AMP-dependent synthetase and ligase
D0853_RS11790	COG2267	carboxylic ester hydrolase activity
D0853_RS11805	COG1214	PFAM Peptidase M22, glycoprotease
D0853_RS11810	COG1199	ATP-dependent helicase activity
D0853_RS11815	COG0788	formyltetrahydrofolate deformylase activity
D0853_RS11820	COG3102	Protein conserved in bacteria
D0853_RS11830	COG0018	arginyl-trna synthetase
D0853_RS11850	COG1918	ferrous iron import across plasma membrane
D0853_RS11865	COG4977	sequence-specific DNA binding
D0853_RS11870	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D0853_RS11875	COG1121	(ABC) transporter
D0853_RS11880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0853_RS11890	COG0045	succinate-CoA ligase (ADP-forming) activity
D0853_RS11895	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0853_RS11900	COG0567	Dehydrogenase, E1 component
D0853_RS11905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0853_RS11910	COG1053	succinate dehydrogenase
D0853_RS11915	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D0853_RS11930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0853_RS11940	COG0033	Phosphoglucomutase
D0853_RS11945	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D0853_RS11950	COG0596	Alpha beta hydrolase
D0853_RS11970	COG0735	belongs to the Fur family
D0853_RS11975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0853_RS11980	COG1263	PTS System
D0853_RS11980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0853_RS11990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0853_RS11995	COG1846	Transcriptional regulator
D0853_RS11995	COG1940	carbohydrate kinase activity
D0853_RS12000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0853_RS12000	COG4651	solute:proton antiporter activity
D0853_RS12005	COG0367	asparagine synthase
D0853_RS12010	COG0250	Participates in transcription elongation, termination and antitermination
D0853_RS12015	COG3104	oligopeptide transport
D0853_RS12020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D0853_RS12025	COG0563	adenylate kinase activity
D0853_RS12030	COG0326	Molecular chaperone. Has ATPase activity
D0853_RS12035	COG3710	Transcriptional regulator
D0853_RS12055	COG0622	Phosphoesterase
D0853_RS12085	COG1090	epimerase
D0853_RS12090	COG0300	oxidoreductase activity
D0853_RS12100	COG3118	belongs to the thioredoxin family
D0853_RS12105	COG0330	HflC and HflK could
D0853_RS12130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0853_RS12135	COG3115	cell septum assembly
D0853_RS12140	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D0853_RS12145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0853_RS12155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_RS12160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0853_RS12165	COG2190	(PTS) system
D0853_RS12175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_RS12180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_RS12190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_RS12200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_RS12210	COG1705	Flagellar rod assembly protein muramidase FlgJ
D0853_RS12210	COG3951	Flagellar rod assembly protein muramidase FlgJ
D0853_RS12215	COG1706	bacterial-type flagellum-dependent cell motility
D0853_RS12220	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0853_RS12230	COG4787	bacterial-type flagellum-dependent cell motility
D0853_RS12240	COG1749	Flagellar hook protein flgE
D0853_RS12250	COG1558	bacterial-type flagellum-dependent cell motility
D0853_RS12255	COG1815	bacterial-type flagellum-dependent cell motility
D0853_RS12260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D0853_RS12265	COG0784	Response regulator, receiver
D0853_RS12265	COG0835	chemotaxis
D0853_RS12325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0853_RS12330	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0853_RS12345	COG2608	mercury ion transmembrane transporter activity
D0853_RS12345	COG2217	Heavy metal translocating P-type atpase
D0853_RS12385	COG2840	Smr protein MutS2
D0853_RS12390	COG1187	pseudouridine synthase activity
D0853_RS12400	COG0737	Belongs to the 5'-nucleotidase family
D0853_RS12405	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D0853_RS12410	COG2912	Transglutaminase-like superfamily
D0853_RS12415	COG3094	Invasion gene expression up-regulator, SirB
D0853_RS12420	COG2890	protein-(glutamine-N5) methyltransferase activity
D0853_RS12425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D0853_RS12430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D0853_RS12435	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D0853_RS12440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D0853_RS12445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0853_RS12450	COG0193	aminoacyl-tRNA hydrolase activity
D0853_RS12455	COG0012	GTP binding
D0853_RS12570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0853_RS12580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0853_RS12585	COG1702	phosphate starvation-inducible protein PhoH
D0853_RS12590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D0853_RS12595	COG4535	Mg2 and Co2 transporter CorC
D0853_RS12600	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D0853_RS12605	COG2888	peptidyl-tyrosine sulfation
D0853_RS12610	COG0495	leucyl-tRNA aminoacylation
D0853_RS12615	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D0853_RS12620	COG1466	dna polymerase III delta subunit
D0853_RS12625	COG0799	negative regulation of ribosome biogenesis
D0853_RS12630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D0853_RS12635	COG0768	penicillin binding
D0853_RS12640	COG0772	Belongs to the SEDS family
D0853_RS12645	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0853_RS12650	COG1686	Belongs to the peptidase S11 family
D0853_RS12655	COG2921	Belongs to the UPF0250 family
D0853_RS12660	COG0321	lipoyl(octanoyl) transferase activity
D0853_RS12665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D0853_RS12670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0853_RS12675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0853_RS12690	COG0366	Alpha amylase catalytic
D0853_RS12695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0853_RS12695	COG1263	PTS System
D0853_RS12705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0853_RS12715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0853_RS12720	COG2011	ABC-type metal ion transport system permease component
D0853_RS12725	COG1464	Belongs to the NlpA lipoprotein family
D0853_RS12730	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D0853_RS12740	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0853_RS12740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0853_RS12755	COG1611	Belongs to the LOG family
D0853_RS12760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0853_RS12770	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D0853_RS12775	COG2363	Small membrane protein
D0853_RS12785	COG0583	DNA-binding transcription factor activity
D0853_RS12790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0853_RS12790	COG0301	tRNA thio-modification
D0853_RS12795	COG2885	chlorophyll binding
D0853_RS12800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0853_RS12805	COG1722	exodeoxyribonuclease VII activity
D0853_RS12810	COG0142	geranyltranstransferase activity
D0853_RS12815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D0853_RS12820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0853_RS12825	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D0853_RS12830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0853_RS12850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0853_RS12850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0853_RS12855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0853_RS12860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0853_RS12865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D0853_RS12875	COG1073	alpha beta
D0853_RS12880	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D0853_RS12885	COG2252	PERMEase
D0853_RS12890	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0853_RS12915	COG0047	phosphoribosylformylglycinamidine synthase activity
D0853_RS12915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0853_RS12920	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D0853_RS12935	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0853_RS12960	COG4969	Belongs to the N-Me-Phe pilin family
D0853_RS12975	COG0484	heat shock protein binding
D0853_RS12980	COG0443	Heat shock 70 kDa protein
D0853_RS12990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D0853_RS12995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D0853_RS13005	COG0497	DNA recombination
D0853_RS13010	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0853_RS13015	COG2914	Belongs to the UPF0125 (RnfH) family
D0853_RS13020	COG2867	negative regulation of translational initiation
D0853_RS13025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D0853_RS13035	COG0582	viral genome integration into host DNA
D0853_RS13045	COG2207	Transcriptional regulator
D0853_RS13070	COG0328	RNA-DNA hybrid ribonuclease activity
D0853_RS13110	COG0583	DNA-binding transcription factor activity
D0853_RS13115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0853_RS13115	COG3153	acetyltransferase
D0853_RS13135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0853_RS13140	COG2873	o-acetylhomoserine
D0853_RS13180	COG1115	amino acid carrier protein
D0853_RS13190	COG1584	GPR1 FUN34 yaaH family protein
D0853_RS13200	COG1757	Na H antiporter
D0853_RS13205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D0853_RS13205	COG0519	Catalyzes the synthesis of GMP from XMP
D0853_RS13210	COG0517	IMP dehydrogenase activity
D0853_RS13210	COG0516	GMP reductase activity
D0853_RS13215	COG1570	exodeoxyribonuclease VII activity
D0853_RS13230	COG1160	GTP binding
D0853_RS13235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0853_RS13240	COG2976	Protein conserved in bacteria
D0853_RS13245	COG0124	histidyl-tRNA synthetase
D0853_RS13250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D0853_RS13265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D0853_RS13270	COG0105	UTP biosynthetic process
D0853_RS13275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D0853_RS13280	COG2975	iron-sulfur cluster assembly
D0853_RS13285	COG0633	Ferredoxin
D0853_RS13290	COG0443	Heat shock 70 kDa protein
D0853_RS13295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0853_RS13305	COG0822	iron-sulfur transferase activity
D0853_RS13310	COG1104	cysteine desulfurase activity
D0853_RS13315	COG1959	2 iron, 2 sulfur cluster binding
D0853_RS13325	COG0483	inositol monophosphate 1-phosphatase activity
D0853_RS13335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0853_RS13340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0853_RS13345	COG1862	Preprotein translocase
D0853_RS13350	COG0343	queuine tRNA-ribosyltransferase activity
D0853_RS13355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D0853_RS13370	COG0517	IMP dehydrogenase activity
D0853_RS13380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0853_RS13390	COG0583	DNA-binding transcription factor activity
D0853_RS13395	COG0450	alkyl hydroperoxide reductase
D0853_RS13405	COG3142	Participates in the control of copper homeostasis
D0853_RS13415	COG0704	Plays a role in the regulation of phosphate uptake
D0853_RS13420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0853_RS13425	COG0581	inorganic phosphate transmembrane transporter activity
D0853_RS13435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D0853_RS13440	COG0248	Ppx GppA phosphatase
D0853_RS13450	COG5002	protein histidine kinase activity
D0853_RS13455	COG0745	RESPONSE REGULATOR receiver
D0853_RS13465	COG2974	May be involved in recombination
D0853_RS13470	COG0826	peptidase U32
D0853_RS13475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0853_RS13535	COG0542	response to heat
D0853_RS13545	COG0564	pseudouridine synthase activity
D0853_RS13550	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0853_RS13555	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D0853_RS13560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0853_RS13565	COG1605	Chorismate mutase
D0853_RS13565	COG0077	Prephenate dehydratase
D0853_RS13570	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D0853_RS13575	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
D0853_RS13585	COG0488	(ABC) transporter
D0853_RS13600	COG0739	heme binding
D0853_RS13605	COG1605	Chorismate mutase
D0853_RS13605	COG0287	Prephenate dehydrogenase
D0853_RS13610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0853_RS13615	COG1472	Belongs to the glycosyl hydrolase 3 family
D0853_RS13620	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D0853_RS13625	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0853_RS13640	COG1966	Carbon starvation protein
D0853_RS13645	COG3275	phosphorelay sensor kinase activity
D0853_RS13650	COG3279	Response regulator of the LytR AlgR family
D0853_RS13655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D0853_RS13660	COG1047	Peptidyl-prolyl cis-trans
D0853_RS13665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D0853_RS13670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D0853_RS13675	COG0196	riboflavin kinase activity
D0853_RS13680	COG0728	peptidoglycan biosynthetic process
D0853_RS13685	COG0268	Binds directly to 16S ribosomal RNA
D0853_RS13695	COG0640	Transcriptional regulator
D0853_RS13705	COG0583	DNA-binding transcription factor activity
D0853_RS13710	COG1283	sodium-dependent phosphate transmembrane transporter activity
D0853_RS13720	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D0853_RS13725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D0853_RS13730	COG0730	response to heat
D0853_RS13740	COG0494	nUDIX hydrolase
D0853_RS13750	COG3066	DNA modification
D0853_RS13760	COG0667	Aldo Keto reductase
D0853_RS13775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D0853_RS13785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D0853_RS13790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0853_RS13795	COG4974	Belongs to the 'phage' integrase family
D0853_RS13800	COG0716	FMN binding
D0853_RS13810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D0853_RS13815	COG0513	Belongs to the DEAD box helicase family
D0853_RS13820	COG3022	response to hydroperoxide
D0853_RS13825	COG1115	amino acid carrier protein
D0853_RS13840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0853_RS13850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D0853_RS13855	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
D0853_RS13860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D0853_RS13865	COG0083	homoserine kinase activity
D0853_RS13880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0853_RS13895	COG0745	RESPONSE REGULATOR receiver
D0853_RS13905	COG2198	Histidine kinase
D0853_RS13905	COG0784	Response regulator, receiver
D0853_RS13905	COG5002	protein histidine kinase activity
D0853_RS13910	COG5001	Diguanylate cyclase
D0853_RS13910	COG4251	negative regulation of phosphorylation
D0853_RS13910	COG3706	GGDEF domain
D0853_RS13910	COG2203	Gaf domain
D0853_RS13915	COG1242	4 iron, 4 sulfur cluster binding
D0853_RS13920	COG0070	glutamate synthase
D0853_RS13920	COG0069	glutamate synthase activity
D0853_RS13920	COG0067	glutamate synthase
D0853_RS13930	COG0067	glutamate synthase
D0853_RS13930	COG0069	glutamate synthase activity
D0853_RS13930	COG0070	glutamate synthase
D0853_RS13935	COG0493	'glutamate synthase
D0853_RS13945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0853_RS13955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0853_RS13960	COG2860	membrane
D0853_RS13965	COG0583	DNA-binding transcription factor activity
D0853_RS13970	COG0730	response to heat
D0853_RS13985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0853_RS13990	COG0505	Belongs to the CarA family
D0853_RS13995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D0853_RS14000	COG0494	nUDIX hydrolase
D0853_RS14005	COG0653	protein targeting
D0853_RS14015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D0853_RS14020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0853_RS14025	COG0849	cell division
D0853_RS14030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0853_RS14035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0853_RS14040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D0853_RS14045	COG0772	Belongs to the SEDS family
D0853_RS14050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D0853_RS14055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0853_RS14060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0853_RS14065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0853_RS14070	COG0768	penicillin binding
D0853_RS14075	COG3116	cell division
D0853_RS14080	COG0275	rRNA processing
D0853_RS14095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D0853_RS14105	COG0792	nuclease activity
D0853_RS14110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D0853_RS14115	COG2823	Periplasmic or secreted lipoprotein
D0853_RS14120	COG2969	positive regulation of protein catabolic process
D0853_RS14125	COG0625	glutathione transferase activity
D0853_RS14130	COG2857	Cytochrome c1
D0853_RS14135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0853_RS14140	COG0723	plastoquinol--plastocyanin reductase activity
D0853_RS14145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D0853_RS14150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D0853_RS14160	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D0853_RS14170	COG3105	Protein conserved in bacteria
D0853_RS14180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0853_RS14185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0853_RS14195	COG3150	esterase
D0853_RS14205	COG3151	Protein conserved in bacteria
D0853_RS14210	COG0494	nUDIX hydrolase
D0853_RS14215	COG1538	Outer membrane efflux protein
D0853_RS14220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D0853_RS14220	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D0853_RS14225	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D0853_RS14240	COG3025	triphosphatase activity
D0853_RS14245	COG1392	Phosphate transport regulator
D0853_RS14250	COG0306	phosphate transporter
D0853_RS14255	COG4991	sh3 domain protein
D0853_RS14265	COG3409	Peptidoglycan-binding domain 1 protein
D0853_RS14265	COG3267	Type II secretory pathway component ExeA
D0853_RS14270	COG0617	tRNA 3'-terminal CCA addition
D0853_RS14275	COG1968	undecaprenyl-diphosphatase activity
D0853_RS14280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0853_RS14285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0853_RS14290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D0853_RS14295	COG0596	Alpha beta hydrolase
D0853_RS14300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D0853_RS14305	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D0853_RS14310	COG1610	YqeY-like protein
D0853_RS14315	COG0358	DNA primase activity
D0853_RS14335	COG3550	peptidyl-serine autophosphorylation
D0853_RS14410	COG0732	type I restriction modification DNA specificity domain
D0853_RS14455	COG1464	Belongs to the NlpA lipoprotein family
D0853_RS14465	COG2207	Transcriptional regulator
D0853_RS14500	COG2213	PTS system mannitol-specific
D0853_RS14500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_RS14505	COG0246	Mannitol dehydrogenase
D0853_RS14510	COG3722	fumarate hydratase activity
D0853_RS14525	COG1461	Dihydroxyacetone kinase
D0853_RS14530	COG2376	Dihydroxyacetone kinase
D0853_RS14540	COG5002	protein histidine kinase activity
D0853_RS14555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0853_RS14560	COG1349	DNA-binding transcription factor activity
D0853_RS14570	COG0469	pyruvate kinase activity
D0853_RS14585	COG0440	acetolactate synthase activity
D0853_RS14590	COG0028	Belongs to the TPP enzyme family
D0853_RS14595	COG1022	Amp-dependent synthetase and ligase
D0853_RS14600	COG0583	DNA-binding transcription factor activity
D0853_RS14620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0853_RS14625	COG0473	3-isopropylmalate dehydrogenase activity
D0853_RS14630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D0853_RS14635	COG0066	3-isopropylmalate dehydratase activity
D0853_RS14645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0853_RS14650	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0853_RS14655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0853_RS14660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D0853_RS14665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D0853_RS14670	COG2967	ApaG domain
D0853_RS14675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0853_RS14690	COG2966	Psort location CytoplasmicMembrane, score
D0853_RS14695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D0853_RS14705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D0853_RS14710	COG0142	geranyltranstransferase activity
D0853_RS14720	COG0039	L-malate dehydrogenase activity
D0853_RS14735	COG2358	TRAP transporter, solute receptor (TAXI family
D0853_RS14755	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D0853_RS14760	COG1178	ABC-type Fe3 transport system permease component
D0853_RS14765	COG4143	(ABC) transporter
D0853_RS14770	COG0163	prenyltransferase activity
D0853_RS14775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0853_RS14785	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D0853_RS14790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D0853_RS14800	COG2105	PFAM AIG2 family protein
D0853_RS14810	COG0729	surface antigen
D0853_RS14815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0853_RS14825	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D0853_RS14840	COG4181	ATPase activity
D0853_RS14860	COG0529	Catalyzes the synthesis of activated sulfate
D0853_RS14865	COG0471	metal ion transport
D0853_RS14865	COG3273	potassium ion transport
D0853_RS14875	COG2895	sulfate adenylyltransferase (ATP) activity
D0853_RS14880	COG0175	sulfate reduction
D0853_RS14885	COG1648	precorrin-2 dehydrogenase activity
D0853_RS14885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0853_RS14900	COG0513	Belongs to the DEAD box helicase family
D0853_RS14905	COG2153	protein acetylation
D0853_RS14915	COG0545	Peptidyl-prolyl cis-trans isomerase
D0853_RS14925	COG0203	ribosomal protein L17
D0853_RS14930	COG0202	RNA polymerase activity
D0853_RS14940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D0853_RS14945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D0853_RS14950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D0853_RS14955	COG0201	protein transport
D0853_RS14960	COG0200	Binds to the 23S rRNA
D0853_RS14965	COG1841	ribosomal large subunit assembly
D0853_RS14980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D0853_RS14985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D0853_RS14990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D0853_RS14995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D0853_RS15000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D0853_RS15005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D0853_RS15010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D0853_RS15015	COG0255	Belongs to the universal ribosomal protein uL29 family
D0853_RS15025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D0853_RS15030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D0853_RS15035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0853_RS15040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D0853_RS15050	COG0088	Forms part of the polypeptide exit tunnel
D0853_RS15055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D0853_RS15065	COG0254	rRNA binding
D0853_RS15075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0853_RS15080	COG1609	Transcriptional regulator
D0853_RS15090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D0853_RS15095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D0853_RS15100	COG1575	Belongs to the MenA family. Type 1 subfamily
D0853_RS15105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0853_RS15110	COG3074	FtsZ-dependent cytokinesis
D0853_RS15120	COG1494	fructose-1,6-bisphosphatase
D0853_RS15145	COG0149	triose-phosphate isomerase activity
D0853_RS15150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D0853_RS15170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0853_RS15185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0853_RS15265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0853_RS15270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0853_RS15275	COG1560	Kdo2-lipid A biosynthetic process
D0853_RS15280	COG0859	PFAM glycosyl transferase family 9
D0853_RS15285	COG1519	Transferase
D0853_RS15305	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS15315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0853_RS15330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0853_RS15340	COG2089	acid synthase
D0853_RS15345	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D0853_RS15350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0853_RS15360	COG3642	lipopolysaccharide core region biosynthetic process
D0853_RS15365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0853_RS15370	COG0859	PFAM glycosyl transferase family 9
D0853_RS15375	COG0463	Glycosyl transferase, family 2
D0853_RS15390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D0853_RS15395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0853_RS15405	COG2194	sulfuric ester hydrolase activity
D0853_RS15415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D0853_RS15420	COG2003	Belongs to the UPF0758 family
D0853_RS15435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D0853_RS15440	COG1309	transcriptional regulator
D0853_RS15445	COG1560	Kdo2-lipid A biosynthetic process
D0853_RS15450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D0853_RS15455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D0853_RS15465	COG1561	YicC-like family, N-terminal region
D0853_RS15475	COG4608	Belongs to the ABC transporter superfamily
D0853_RS15480	COG0444	Belongs to the ABC transporter superfamily
D0853_RS15485	COG0747	negative chemotaxis
D0853_RS15490	COG4239	(ABC) transporter, permease
D0853_RS15495	COG4174	ABC transporter (Permease)
D0853_RS15520	COG0811	peptide transport
D0853_RS15525	COG0848	biopolymer transport protein
D0853_RS15540	COG0194	GDP metabolic process
D0853_RS15545	COG1758	RNA polymerase activity
D0853_RS15550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0853_RS15555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0853_RS15560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0853_RS15570	COG2233	PERMEase
D0853_RS15590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0853_RS15600	COG2183	response to ionizing radiation
D0853_RS15610	COG0596	Alpha beta hydrolase
D0853_RS15615	COG1040	competence protein
D0853_RS15620	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D0853_RS15620	COG0316	Belongs to the HesB IscA family
D0853_RS15625	COG0494	nUDIX hydrolase
D0853_RS15630	COG1218	3'(2'),5'-bisphosphate nucleotidase
D0853_RS15640	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D0853_RS15645	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D0853_RS15650	COG3156	type II secretion system protein K
D0853_RS15655	COG4795	General secretion pathway protein
D0853_RS15660	COG2165	general secretion pathway protein
D0853_RS15665	COG2165	general secretion pathway protein
D0853_RS15670	COG2165	general secretion pathway protein
D0853_RS15675	COG1459	type II secretion system
D0853_RS15680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0853_RS15690	COG3031	protein transport across the cell outer membrane
D0853_RS15695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D0853_RS15700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D0853_RS15705	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D0853_RS15715	COG0456	acetyltransferase
D0853_RS15720	COG1490	D-aminoacyl-tRNA deacylase activity
D0853_RS15725	COG1295	ribonuclease BN
D0853_RS15740	COG1217	gtp-binding protein TYPA
D0853_RS15745	COG0174	glutamine synthetase
D0853_RS15755	COG3852	Histidine kinase
D0853_RS15760	COG2204	response regulator
D0853_RS15770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0853_RS15785	COG3078	GTPase activator activity
D0853_RS15805	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D0853_RS15815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0853_RS15815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0853_RS15840	COG0084	hydrolase, TatD family'
D0853_RS15850	COG0805	protein transport
D0853_RS15855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0853_RS15860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0853_RS15865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0853_RS15870	COG3165	ubiquinone biosynthetic process from chorismate
D0853_RS15875	COG2226	methyltransferase
D0853_RS15880	COG1322	Protein conserved in bacteria
D0853_RS15895	COG0628	permease
D0853_RS15925	COG1597	lipid kinase activity
D0853_RS15955	COG2081	HI0933 family
D0853_RS15965	COG1528	Iron-storage protein
D0853_RS15970	COG0589	response to stress
D0853_RS15985	COG0742	ribosomal rna small subunit methyltransferase
D0853_RS15990	COG5001	Diguanylate cyclase
D0853_RS15990	COG5002	protein histidine kinase activity
D0853_RS15995	COG1522	sequence-specific DNA binding
D0853_RS16000	COG0339	signal peptide processing
D0853_RS16010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D0853_RS16015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0853_RS16020	COG0583	DNA-binding transcription factor activity
D0853_RS16025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D0853_RS16030	COG0800	Aldolase
D0853_RS16035	COG2610	gluconate transmembrane transporter activity
D0853_RS16040	COG3265	gluconokinase activity
D0853_RS16045	COG0129	dihydroxy-acid dehydratase activity
D0853_RS16060	COG0583	DNA-binding transcription factor activity
D0853_RS16065	COG1609	Transcriptional regulator
D0853_RS16105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0853_RS16110	COG0601	transmembrane transport
D0853_RS16115	COG0747	negative chemotaxis
D0853_RS16120	COG4172	Belongs to the ABC transporter superfamily
D0853_RS16185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_RS16190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_RS16200	COG2960	long-chain fatty acid transporting porin activity
D0853_RS16205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D0853_RS16210	COG0583	DNA-binding transcription factor activity
D0853_RS16255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0853_RS16265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0853_RS16270	COG0408	coproporphyrinogen oxidase activity
D0853_RS16275	COG0009	L-threonylcarbamoyladenylate synthase
D0853_RS16280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0853_RS16285	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0853_RS16290	COG0551	DNA topoisomerase type I activity
D0853_RS16295	COG2922	Belongs to the Smg family
D0853_RS16300	COG0758	DNA mediated transformation
D0853_RS16310	COG0242	peptide deformylase activity
D0853_RS16315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0853_RS16320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0853_RS16320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0853_RS16325	COG0569	domain protein
D0853_RS16330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0853_RS16340	COG1272	protein, Hemolysin III
D0853_RS16345	COG4326	sporulation control protein
D0853_RS16355	COG3084	Protein conserved in bacteria
D0853_RS16365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0853_RS16370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0853_RS16375	COG0204	Acyl-transferase
D0853_RS16385	COG0606	chelatase, subunit chli
D0853_RS16395	COG3978	acetolactate synthase activity
D0853_RS16400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0853_RS16405	COG0129	dihydroxy-acid dehydratase activity
D0853_RS16415	COG0583	DNA-binding transcription factor activity
D0853_RS16420	COG2814	Major facilitator Superfamily
D0853_RS16425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_RS16430	COG0765	amino acid transport
D0853_RS16435	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D0853_RS16440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0853_RS16445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D0853_RS16450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0853_RS16455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D0853_RS16460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0853_RS16475	COG0356	it plays a direct role in the translocation of protons across the membrane
D0853_RS16480	COG3312	ion transport
D0853_RS16485	COG1475	DNA binding
D0853_RS16490	COG1192	Involved in chromosome partitioning
D0853_RS16495	COG0357	Ribosomal RNA small subunit methyltransferase G
D0853_RS16500	COG0445	tRNA wobble uridine modification
D0853_RS16505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0853_RS16510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D0853_RS16515	COG0706	membrane insertase activity
D0853_RS16525	COG0594	ribonuclease P activity
D0853_RS16535	COG1126	abc transporter atp-binding protein
D0853_RS16570	COG1335	isochorismatase
D0853_RS16580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D0853_RS16610	COG0583	DNA-binding transcription factor activity
D0853_RS16625	COG3713	MltA-interacting MipA family protein
D0853_RS16635	COG3015	lipoprotein NlpE involved in copper resistance
D0853_RS16645	COG1342	Belongs to the UPF0251 family
D0853_RS16680	COG4948	Mandelate Racemase Muconate Lactonizing
D0853_RS16690	COG0583	DNA-binding transcription factor activity
D0853_RS16740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0853_RS16785	COG3842	ATPase activity
D0853_RS16815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0853_RS16835	COG3706	GGDEF domain
D0853_RS16855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_RS16875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0853_RS16895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0853_RS16895	COG0574	Belongs to the PEP-utilizing enzyme family
D0853_RS16900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D0853_RS16905	COG0252	asparaginase activity
D0853_RS16910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0853_RS16915	COG0583	DNA-binding transcription factor activity
D0853_RS16930	COG3122	Protein conserved in bacteria
D0853_RS16945	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS16955	COG1063	alcohol dehydrogenase
D0853_RS16960	COG1902	pentaerythritol trinitrate reductase activity
D0853_RS16975	COG0583	DNA-binding transcription factor activity
D0853_RS16985	COG0513	Belongs to the DEAD box helicase family
D0853_RS17030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0853_RS17035	COG2207	Transcriptional regulator
D0853_RS17035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0853_RS17065	COG2354	Protein conserved in bacteria
D0853_RS17070	COG0418	dihydroorotase activity
D0853_RS17080	COG0401	homolog of Blt101
D0853_RS17090	COG0633	Ferredoxin
D0853_RS17090	COG3217	Mosc domain protein beta barrel domain protein
D0853_RS17090	COG3217	Mosc domain protein beta barrel domain protein
D0853_RS17090	COG0633	Ferredoxin
D0853_RS17095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D0853_RS17100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0853_RS17145	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D0853_RS17150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0853_RS17160	COG0848	biopolymer transport protein
D0853_RS17165	COG0811	peptide transport
D0853_RS17170	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D0853_RS17180	COG3721	Heme iron utilization protein
D0853_RS17185	COG0748	coenzyme F420 binding
D0853_RS17195	COG0835	chemotaxis
D0853_RS17195	COG0784	Response regulator, receiver
D0853_RS17205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0853_RS17210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D0853_RS17240	COG0328	RNA-DNA hybrid ribonuclease activity
D0853_RS17315	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D0853_RS17320	COG0783	Belongs to the Dps family
D0853_RS17330	COG0583	DNA-binding transcription factor activity
D0853_RS17345	COG4934	collagen metabolic process
D0853_RS17355	COG0366	Alpha amylase catalytic
D0853_RS17375	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0853_RS17380	COG0589	response to stress
D0853_RS17385	COG0488	(ABC) transporter
D0853_RS17390	COG1505	serine-type exopeptidase activity
D0853_RS17400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_RS17410	COG2067	long-chain fatty acid transport protein
D0853_RS17420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0853_RS17450	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_RS17475	COG3383	formate dehydrogenase (NAD+) activity
D0853_RS17490	COG0842	Transport permease protein
D0853_RS17495	COG1131	(ABC) transporter
D0853_RS17515	COG2706	6-phosphogluconolactonase activity
D0853_RS17525	COG1881	PFAM PEBP family protein
D0853_RS17535	COG0798	PFAM Bile acid sodium symporter
D0853_RS17555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_RS17560	COG2213	PTS system mannitol-specific
D0853_RS17565	COG1063	alcohol dehydrogenase
D0853_RS17575	COG1072	(Pantothenic acid kinase))
D0853_RS17580	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0853_RS17600	COG0814	amino acid
D0853_RS17615	COG3314	Sporulation integral membrane protein YlbJ
D0853_RS17640	COG0739	heme binding
D0853_RS17645	COG5001	Diguanylate cyclase
D0853_RS17650	COG0583	DNA-binding transcription factor activity
D0853_RS17655	COG2814	Major facilitator Superfamily
D0853_RS17680	COG0697	spore germination
D0853_RS17710	COG2207	Transcriptional regulator
D0853_RS17715	COG1280	lysine exporter protein (LysE YggA)
D0853_RS17725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0853_RS17730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0853_RS17740	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D0853_RS17765	COG1612	heme a metabolic process
D0853_RS17770	COG0109	protoheme IX farnesyltransferase activity
D0853_RS17775	COG0545	Peptidyl-prolyl cis-trans isomerase
D0853_RS17810	COG1278	Cold shock
D0853_RS17815	COG3036	rescue of stalled ribosome
D0853_RS17830	COG2199	diguanylate cyclase activity
D0853_RS17850	COG0577	efflux transmembrane transporter activity
D0853_RS17850	COG1136	(ABC) transporter
D0853_RS17860	COG0840	transmembrane signaling receptor activity
D0853_RS17870	COG0783	Belongs to the Dps family
D0853_RS17880	COG2133	pyrroloquinoline quinone binding
D0853_RS17885	COG1454	alcohol dehydrogenase
D0853_RS17890	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D0853_RS17930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0853_RS17935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0853_RS17940	COG3186	Phenylalanine-4-hydroxylase
D0853_RS17945	COG2154	pterin-4-alpha-carbinolamine dehydratase
D0853_RS17970	COG3530	Putative quorum-sensing-regulated virulence factor
D0853_RS17975	COG0513	Belongs to the DEAD box helicase family
D0853_RS17980	COG4628	conserved protein (DUF2132)
D0853_RS17985	COG0133	tryptophan synthase activity
D0853_RS17995	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D0853_RS18005	COG0523	cobalamin synthesis protein
D0853_RS18010	COG0513	Belongs to the DEAD box helicase family
D0853_RS18030	COG2200	EAL domain
D0853_RS18035	COG1119	ATPase activity
D0853_RS18040	COG0840	transmembrane signaling receptor activity
D0853_RS18065	COG0641	radical SAM
D0853_RS18085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0853_RS18100	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D0853_RS18105	COG0513	Belongs to the DEAD box helicase family
D0853_RS18110	COG5001	Diguanylate cyclase
D0853_RS18120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0853_RS18135	COG5413	integral membrane protein
D0853_RS18145	COG1024	Enoyl-CoA hydratase
D0853_RS18150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0853_RS18155	COG1960	acyl-CoA dehydrogenase activity
D0853_RS18165	COG0183	Belongs to the thiolase family
D0853_RS18180	COG1024	Enoyl-CoA hydratase
D0853_RS18185	COG1024	Enoyl-CoA hydratase
D0853_RS18195	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS18200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0853_RS18205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0853_RS18210	COG1845	cytochrome c oxidase, subunit III
D0853_RS18215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0853_RS18220	COG0109	protoheme IX farnesyltransferase activity
D0853_RS18235	COG1902	pentaerythritol trinitrate reductase activity
D0853_RS18245	COG1126	abc transporter atp-binding protein
D0853_RS18250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_RS18255	COG4215	(ABC) transporter
D0853_RS18260	COG4160	amino acid transport
D0853_RS18275	COG0625	glutathione transferase activity
D0853_RS18315	COG0443	Heat shock 70 kDa protein
D0853_RS18320	COG2847	Copper chaperone PCu(A)C
D0853_RS18345	COG4607	ABC-type enterochelin transport system periplasmic component
D0853_RS18350	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0853_RS18355	COG4605	iron ion homeostasis
D0853_RS18360	COG4604	ABC transporter, ATP-binding protein
D0853_RS18365	COG0789	Transcriptional regulator
D0853_RS18380	COG4771	TonB-dependent receptor
D0853_RS18380	COG1629	transport
D0853_RS18415	COG1289	transmembrane transporter activity
D0853_RS18420	COG0210	DNA helicase
D0853_RS18425	COG1803	Methylglyoxal synthase
D0853_RS18430	COG1879	ABC-type sugar transport system periplasmic component
D0853_RS18435	COG0784	Response regulator, receiver
D0853_RS18435	COG2198	Histidine kinase
D0853_RS18435	COG2205	protein histidine kinase activity
D0853_RS18450	COG0745	RESPONSE REGULATOR receiver
D0853_RS18455	COG3119	arylsulfatase activity
D0853_RS18460	COG3119	arylsulfatase activity
D0853_RS18475	COG3119	arylsulfatase activity
D0853_RS18480	COG0641	radical SAM
D0853_RS18485	COG0714	Associated with various cellular activities
D0853_RS18515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0853_RS18515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0853_RS18520	COG0583	DNA-binding transcription factor activity
D0853_RS18525	COG1597	lipid kinase activity
D0853_RS18530	COG3111	PFAM Bacterial OB fold (BOF) protein
D0853_RS18550	COG0641	radical SAM
D0853_RS18580	COG0501	Belongs to the peptidase M48B family
D0853_RS18585	COG1704	LemA family
D0853_RS18590	COG3069	C4-dicarboxylate transmembrane transporter activity
D0853_RS18600	COG1214	PFAM Peptidase M22, glycoprotease
D0853_RS18600	COG0456	acetyltransferase
D0853_RS18620	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D0853_RS18640	COG2207	Transcriptional regulator
D0853_RS18665	COG4964	Belongs to the GSP D family
D0853_RS18725	COG0583	DNA-binding transcription factor activity
D0853_RS18730	COG0583	DNA-binding transcription factor activity
D0853_RS18745	COG3300	MHYT domain
D0853_RS18745	COG5001	Diguanylate cyclase
D0853_RS18750	COG2197	response regulator
D0853_RS18755	COG3706	GGDEF domain
D0853_RS18765	COG2197	response regulator
D0853_RS18790	COG0835	chemotaxis
D0853_RS18790	COG0784	Response regulator, receiver
D0853_RS18795	COG2165	general secretion pathway protein
D0853_RS18810	COG2962	Rard protein
D0853_RS18825	COG0671	phosphoesterase, PA-phosphatase related
D0853_RS18840	COG2076	Multidrug Resistance protein
D0853_RS18870	COG0471	metal ion transport
D0853_RS18875	COG3290	protein histidine kinase activity
D0853_RS18880	COG4565	transcriptional regulatory protein
D0853_RS18900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D0853_RS18905	COG5642	Protein of unknown function (DUF2384)
D0853_RS18925	COG1902	pentaerythritol trinitrate reductase activity
D0853_RS18930	COG0346	lactoylglutathione lyase activity
D0853_RS18950	COG2239	Acts as a magnesium transporter
D0853_RS18980	COG0242	peptide deformylase activity
D0853_RS19025	COG2176	DNA-directed DNA polymerase activity
D0853_RS19030	COG0583	DNA-binding transcription factor activity
D0853_RS19035	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D0853_RS19040	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D0853_RS19065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0853_RS19065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0853_RS19070	COG0509	glycine decarboxylation via glycine cleavage system
D0853_RS19075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0853_RS19095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_RS19115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_RS19115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_RS19115	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D0853_RS19120	COG1105	Belongs to the carbohydrate kinase PfkB family
D0853_RS19125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_RS19125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_RS19130	COG1609	Transcriptional regulator
D0853_RS19150	COG2199	diguanylate cyclase activity
D0853_RS19150	COG2200	EAL domain
D0853_RS19150	COG2203	Gaf domain
D0853_RS19155	COG0765	amino acid transport
D0853_RS19160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_RS19165	COG0765	amino acid transport
D0853_RS19170	COG1126	abc transporter atp-binding protein
D0853_RS19175	COG0469	pyruvate kinase activity
D0853_RS19180	COG2271	Major facilitator Superfamily
D0853_RS19205	COG1979	alcohol dehydrogenase
D0853_RS19210	COG2207	Transcriptional regulator
D0853_RS19225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0853_RS19230	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D0853_RS19235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0853_RS19255	COG3437	response regulator, receiver
D0853_RS19255	COG0784	Response regulator, receiver
D0853_RS19265	COG0546	phosphoglycolate phosphatase activity
D0853_RS19275	COG0840	transmembrane signaling receptor activity
D0853_RS19285	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D0853_RS19290	COG0513	Belongs to the DEAD box helicase family
D0853_RS19295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0853_RS19310	COG3038	cytochrome b561
D0853_RS19315	COG2353	YceI-like domain
D0853_RS19320	COG2116	formate transmembrane transporter activity
D0853_RS19325	COG0583	DNA-binding transcription factor activity
D0853_RS19335	COG3593	DNA synthesis involved in DNA repair
D0853_RS19340	COG0737	Belongs to the 5'-nucleotidase family
D0853_RS19345	COG0861	Integral membrane protein TerC family
D0853_RS19360	COG2267	carboxylic ester hydrolase activity
D0853_RS19365	COG2067	long-chain fatty acid transport protein
D0853_RS19380	COG2050	protein possibly involved in aromatic compounds catabolism
D0853_RS19415	COG0484	heat shock protein binding
D0853_RS19425	COG3300	MHYT domain
D0853_RS19425	COG5001	Diguanylate cyclase
D0853_RS19430	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0853_RS19440	COG4181	ATPase activity
D0853_RS19445	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D0853_RS19450	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D0853_RS19450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0853_RS19455	COG1984	allophanate hydrolase subunit 2
D0853_RS19460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D0853_RS19465	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D0853_RS19470	COG5001	Diguanylate cyclase
D0853_RS19470	COG5002	protein histidine kinase activity
D0853_RS19470	COG3447	MASE1 domain protein
D0853_RS19475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0853_RS19485	COG4771	TonB-dependent receptor
D0853_RS19485	COG1629	transport
D0853_RS19490	COG0583	DNA-binding transcription factor activity
D0853_RS19495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0853_RS19495	COG1042	CoA-binding domain protein
D0853_RS19495	COG0045	succinate-CoA ligase (ADP-forming) activity
D0853_RS19505	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0853_RS19515	COG0023	Translation Initiation Factor
D0853_RS19660	COG0583	DNA-binding transcription factor activity
D0853_RS19670	COG0589	response to stress
D0853_RS19675	COG3140	Belongs to the UPF0181 family
D0853_RS19700	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D0853_RS19705	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D0853_RS19730	COG2203	Gaf domain
D0853_RS19730	COG5001	Diguanylate cyclase
D0853_RS19730	COG4251	negative regulation of phosphorylation
D0853_RS19730	COG3706	GGDEF domain
D0853_RS19740	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D0853_RS19745	COG4149	molybdate abc transporter
D0853_RS19750	COG0725	ABC transporter, periplasmic molybdate-binding protein
D0853_RS19755	COG1492	cobalamin metabolic process
D0853_RS19760	COG3111	PFAM Bacterial OB fold (BOF) protein
D0853_RS19770	COG4067	protein conserved in archaea
D0853_RS19770	COG0189	ligase activity
D0853_RS19790	COG0534	Mate efflux family protein
D0853_RS19795	COG0602	queuosine metabolic process
D0853_RS19800	COG1328	CTP reductase activity
D0853_RS19815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_RS19895	COG0243	molybdopterin cofactor binding
D0853_RS19905	COG0583	DNA-binding transcription factor activity
D0853_RS19910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D0853_RS19920	COG2197	response regulator
D0853_RS19925	COG3851	Histidine kinase
D0853_RS19930	COG2271	Major facilitator Superfamily
D0853_RS19955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0853_RS19960	COG3118	belongs to the thioredoxin family
D0853_RS19970	COG2205	protein histidine kinase activity
D0853_RS19970	COG0745	RESPONSE REGULATOR receiver
D0853_RS19970	COG3292	Two component regulator propeller
D0853_RS19975	COG0534	Mate efflux family protein
D0853_RS20010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0853_RS20030	COG2116	formate transmembrane transporter activity
D0853_RS20040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0853_RS20045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0853_RS20090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0853_RS20090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D0853_RS20135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0853_RS20155	COG0277	FAD linked oxidase domain protein
D0853_RS20160	COG0583	DNA-binding transcription factor activity
D0853_RS20180	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D0853_RS20195	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D0853_RS20210	COG1288	antiporter activity
D0853_RS20220	COG2814	Major facilitator Superfamily
D0853_RS20230	COG3040	lipid binding
D0853_RS20250	COG0419	ATPase involved in DNA repair
D0853_RS20255	COG0420	3'-5' exonuclease activity
D0853_RS20325	COG0631	protein serine/threonine phosphatase activity
D0853_RS20360	COG0515	serine threonine protein kinase
D0853_RS20360	COG2815	serine threonine protein kinase
D0853_RS20415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0853_RS20415	COG2146	nitrite reductase [NAD(P)H] activity
D0853_RS20420	COG1116	anion transmembrane transporter activity
D0853_RS20425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0853_RS20430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0853_RS20440	COG3707	response regulator
D0853_RS20460	COG1648	precorrin-2 dehydrogenase activity
D0853_RS20460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0853_RS20465	COG0243	molybdopterin cofactor binding
D0853_RS20475	COG0814	amino acid
D0853_RS20505	COG1785	Belongs to the alkaline phosphatase family
D0853_RS20520	COG0745	RESPONSE REGULATOR receiver
D0853_RS20540	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D0853_RS20555	COG1609	Transcriptional regulator
D0853_RS20560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0853_RS20565	COG1879	ABC-type sugar transport system periplasmic component
D0853_RS20570	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0853_RS20575	COG1129	ABC transporter
D0853_RS20580	COG1869	D-ribose catabolic process
D0853_RS20585	COG5001	Diguanylate cyclase
D0853_RS20590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0853_RS20650	COG2205	protein histidine kinase activity
D0853_RS20650	COG0784	Response regulator, receiver
D0853_RS20670	COG5001	Diguanylate cyclase
D0853_RS20670	COG3300	MHYT domain
D0853_RS20680	COG0330	HflC and HflK could
D0853_RS20695	COG4175	Glycine betaine
D0853_RS20695	COG0517	IMP dehydrogenase activity
D0853_RS20700	COG4176	ABC-type proline glycine betaine transport system permease component
D0853_RS20715	COG1012	belongs to the aldehyde dehydrogenase family
D0853_RS20720	COG1309	transcriptional regulator
D0853_RS20725	COG3706	GGDEF domain
D0853_RS20735	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS20750	COG1024	Enoyl-CoA hydratase
D0853_RS20755	COG1960	acyl-CoA dehydrogenase activity
D0853_RS20765	COG0183	Belongs to the thiolase family
D0853_RS20775	COG1960	acyl-CoA dehydrogenase activity
D0853_RS20780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0853_RS20800	COG2205	protein histidine kinase activity
D0853_RS20800	COG3437	response regulator, receiver
D0853_RS20800	COG4999	Histidine kinase
D0853_RS20800	COG3850	Histidine kinase
D0853_RS20815	COG3264	Mechanosensitive ion channel
D0853_RS20815	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D0853_RS20825	COG0110	maltose O-acetyltransferase activity
D0853_RS20830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0853_RS20835	COG1271	oxidase subunit
D0853_RS20840	COG1294	oxidase, subunit
D0853_RS20850	COG0384	phenazine biosynthesis protein PhzF
D0853_RS20855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0853_RS20860	COG0789	Transcriptional regulator
D0853_RS20870	COG3474	cytochrome
D0853_RS20940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0853_RS20945	COG0516	GMP reductase activity
D0853_RS20950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0853_RS20950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D0853_RS20965	COG4989	oxidoreductase activity
D0853_RS20980	COG0038	chloride channel
D0853_RS20990	COG1914	H( )-stimulated, divalent metal cation uptake system
D0853_RS20995	COG0302	gtp cyclohydrolase
D0853_RS21005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0853_RS21025	COG2897	thiosulfate sulfurtransferase activity
D0853_RS21055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0853_RS21060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0853_RS21065	COG0840	transmembrane signaling receptor activity
D0853_RS21075	COG2814	Major facilitator Superfamily
D0853_RS21080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0853_RS21095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0853_RS21105	COG0840	transmembrane signaling receptor activity
D0853_RS21125	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0853_RS21140	COG2197	response regulator
D0853_RS21145	COG3850	Histidine kinase
D0853_RS21150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0853_RS21160	COG0243	molybdopterin cofactor binding
D0853_RS21170	COG3005	denitrification pathway
D0853_RS21190	COG0183	Belongs to the thiolase family
D0853_RS21200	COG1280	lysine exporter protein (LysE YggA)
D0853_RS21210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0853_RS21215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0853_RS21245	COG1522	sequence-specific DNA binding
D0853_RS21265	COG1566	PFAM secretion protein HlyD family protein
D0853_RS21275	COG0784	Response regulator, receiver
D0853_RS21275	COG2205	protein histidine kinase activity
D0853_RS21280	COG1879	ABC-type sugar transport system periplasmic component
D0853_RS21285	COG2827	Endonuclease containing a URI domain
D0853_RS21290	COG3132	Protein of unknown function, DUF480
D0853_RS21305	COG2926	Belongs to the UPF0265 family
D0853_RS21310	COG0534	Mate efflux family protein
D0853_RS21315	COG0673	inositol 2-dehydrogenase activity
D0853_RS21320	COG2205	protein histidine kinase activity
D0853_RS21320	COG5002	protein histidine kinase activity
D0853_RS21320	COG0784	Response regulator, receiver
D0853_RS21340	COG0583	DNA-binding transcription factor activity
D0853_RS21345	COG1522	sequence-specific DNA binding
D0853_RS21355	COG0531	amino acid
D0853_RS21370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0853_RS21375	COG2239	Acts as a magnesium transporter
D0853_RS21385	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D0853_RS21390	COG0402	S-adenosylhomocysteine deaminase activity
D0853_RS21400	COG1418	mRNA catabolic process
D0853_RS21415	COG2814	Major facilitator Superfamily
D0853_RS21425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0853_RS21515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0853_RS21540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0853_RS21560	COG4221	oxidoreductase activity
D0853_RS21565	COG0745	RESPONSE REGULATOR receiver
D0853_RS21570	COG2205	protein histidine kinase activity
D0853_RS21580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0853_RS21585	COG2194	sulfuric ester hydrolase activity
D0853_RS21590	COG0673	inositol 2-dehydrogenase activity
D0853_RS21600	COG2814	Major facilitator Superfamily
D0853_RS21625	COG4667	esterase of the alpha-beta hydrolase superfamily
D0853_RS21635	COG1278	Cold shock
D0853_RS21655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0853_RS21675	COG1686	Belongs to the peptidase S11 family
D0853_RS21690	COG0625	glutathione transferase activity
D0853_RS21700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0853_RS21725	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS21745	COG3746	phosphate-selective porin O and P
D0853_RS21850	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0853_RS21955	COG4790	Type iii secretion
D0853_RS21990	COG3710	Transcriptional regulator
D0853_RS22020	COG4792	protein secretion
D0853_RS22025	COG4789	Type iii secretion
D0853_RS22140	COG3064	Membrane
D0853_RS22265	COG3833	ABC-type maltose transport systems, permease component
D0853_RS22270	COG1175	transmembrane transport
D0853_RS22280	COG3842	ATPase activity
D0853_RS22340	COG3097	Belongs to the UPF0267 family
D0853_RS22345	COG1309	transcriptional regulator
D0853_RS22350	COG2130	NADP-dependent
D0853_RS22360	COG0753	catalase activity
D0853_RS22365	COG2084	Dehydrogenase
D0853_RS22370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_RS22375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_RS22385	COG2207	Transcriptional regulator
D0853_RS22390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_RS22390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_RS22390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_RS22405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0853_RS22410	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D0853_RS22420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0853_RS22425	COG0569	domain protein
D0853_RS22435	COG2205	protein histidine kinase activity
D0853_RS22440	COG1132	(ABC) transporter
D0853_RS22445	COG4774	siderophore transport
D0853_RS22450	COG1120	ATPase activity
D0853_RS22455	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D0853_RS22505	COG2197	response regulator
D0853_RS22515	COG0840	transmembrane signaling receptor activity
D0853_RS22525	COG0714	Associated with various cellular activities
D0853_RS22545	COG2304	oxidoreductase activity
D0853_RS22560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0853_RS22565	COG0581	inorganic phosphate transmembrane transporter activity
D0853_RS22570	COG0573	inorganic phosphate transmembrane transporter activity
D0853_RS22600	COG4771	TonB-dependent receptor
D0853_RS22605	COG1770	oligopeptidase
D0853_RS22610	COG0513	Belongs to the DEAD box helicase family
D0853_RS22620	COG1388	LysM domain
D0853_RS22620	COG1376	ErfK ybiS ycfS ynhG family protein
D0853_RS22625	COG0415	Belongs to the DNA photolyase family
D0853_RS22630	COG0789	Transcriptional regulator
D0853_RS22635	COG3272	Protein of unknown function (DUF1722)
D0853_RS22645	COG0813	purine-nucleoside phosphorylase activity
D0853_RS22660	COG3706	GGDEF domain
D0853_RS22670	COG1566	PFAM secretion protein HlyD family protein
D0853_RS22675	COG4720	Psort location CytoplasmicMembrane, score
D0853_RS22680	COG1122	ATPase activity
D0853_RS22695	COG0348	domain, Protein
D0853_RS22700	COG0437	4 iron, 4 sulfur cluster binding
D0853_RS22705	COG1247	-acetyltransferase
D0853_RS22735	COG1067	ATP-dependent peptidase activity
D0853_RS22745	COG4172	Belongs to the ABC transporter superfamily
D0853_RS22750	COG1505	serine-type exopeptidase activity
D0853_RS22755	COG0583	DNA-binding transcription factor activity
D0853_RS22760	COG1620	l-lactate permease
D0853_RS22765	COG1304	FMN binding
D0853_RS22775	COG0668	transmembrane transport
D0853_RS22815	COG1063	alcohol dehydrogenase
D0853_RS22820	COG0156	8-amino-7-oxononanoate synthase activity
D0853_RS22830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_RS22850	COG0745	RESPONSE REGULATOR receiver
D0853_RS22885	COG0346	lactoylglutathione lyase activity
D0853_RS22905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0853_RS22985	COG1987	bacterial-type flagellum assembly
D0853_RS22995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0853_RS23010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_RS23020	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D0853_RS23025	COG1516	flagellar protein fliS
D0853_RS23040	COG1580	Controls the rotational direction of flagella during chemotaxis
D0853_RS23045	COG1191	sigma factor activity
D0853_RS23050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0853_RS23055	COG1360	Flagellar Motor Protein
D0853_RS23105	COG1882	Formate acetyltransferase
D0853_RS23110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0853_RS23115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0853_RS23125	COG0454	-acetyltransferase
D0853_RS23140	COG2814	Major facilitator Superfamily
D0853_RS23185	COG0628	permease
D0853_RS23190	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0853_RS23200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0853_RS23210	COG4628	conserved protein (DUF2132)
D0853_RS23215	COG0583	DNA-binding transcription factor activity
D0853_RS23240	COG1686	Belongs to the peptidase S11 family
D0853_RS23255	COG1054	Belongs to the UPF0176 family
D0853_RS23260	COG3397	chitin binding
D0853_RS23265	COG4667	esterase of the alpha-beta hydrolase superfamily
D0853_RS23270	COG2095	MarC family integral membrane protein
D0853_RS23290	COG0489	protein tyrosine kinase activity
D0853_RS23290	COG3206	protein involved in exopolysaccharide biosynthesis
D0853_RS23305	COG0583	DNA-binding transcription factor activity
D0853_RS23315	COG1301	dicarboxylic acid transport
D0853_RS23320	COG3339	Conserved Protein
D0853_RS23325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0853_RS23330	COG0700	Nucleoside recognition
D0853_RS23335	COG3366	ferrous iron transmembrane transporter activity
D0853_RS23350	COG0366	Alpha amylase catalytic
D0853_RS23355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0853_RS23360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0853_RS23365	COG1640	4-alpha-glucanotransferase
D0853_RS23370	COG0058	SHG alpha-glucan phosphorylase activity
D0853_RS23385	COG2909	trisaccharide binding
D0853_RS23400	COG1999	signal sequence binding
D0853_RS23410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0853_RS23410	COG1263	PTS System
D0853_RS23415	COG1162	GTPase activity
D0853_RS23420	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D0853_RS23430	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D0853_RS23440	COG0531	amino acid
D0853_RS23445	COG1982	Orn Lys Arg decarboxylase major
D0853_RS23465	COG2356	endonuclease I
D0853_RS23490	COG4580	involved in the transport of maltose and maltodextrins
D0853_RS23515	COG0739	heme binding
D0853_RS23525	COG0612	Peptidase, M16
D0853_RS23530	COG0840	transmembrane signaling receptor activity
D0853_RS23535	COG1120	ATPase activity
D0853_RS23540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0853_RS23545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0853_RS23550	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D0853_RS23555	COG4772	TonB-dependent receptor
D0853_RS23580	COG4264	IucA IucC family
D0853_RS23585	COG0019	diaminopimelate decarboxylase activity
D0853_RS23590	COG1653	transport
D0853_RS23595	COG0642	Histidine kinase
D0853_RS23620	COG0826	peptidase U32
D0853_RS23625	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0853_RS23630	COG1129	ABC transporter
D0853_RS23635	COG1879	ABC-type sugar transport system periplasmic component
D0853_RS23640	COG1069	ribulokinase activity
D0853_RS23650	COG2160	L-arabinose isomerase activity
D0853_RS23675	COG1764	response to oxidative stress
D0853_RS23680	COG1846	Transcriptional regulator
D0853_RS23690	COG3634	alkyl hydroperoxide reductase activity
D0853_RS23725	COG1595	DNA-templated transcription, initiation
D0853_RS23745	COG0583	DNA-binding transcription factor activity
D0853_RS23750	COG1486	melibiose metabolic process
D0853_RS23765	COG2258	MOSC domain
D0853_RS23770	COG0513	Belongs to the DEAD box helicase family
D0853_RS23775	COG1312	Catalyzes the dehydration of D-mannonate
D0853_RS23780	COG2186	Transcriptional regulator
D0853_RS23790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0853_RS23800	COG0246	Mannitol dehydrogenase
D0853_RS23805	COG1904	glucuronate isomerase
D0853_RS23810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0853_RS23815	COG0800	Aldolase
D0853_RS23840	COG2207	Transcriptional regulator
D0853_RS23850	COG1132	(ABC) transporter
D0853_RS23895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0853_RS23925	COG0259	pyridoxamine-phosphate oxidase activity
D0853_RS23970	COG4166	transmembrane transport
D0853_RS23990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0853_RS23995	COG1263	PTS System
D0853_RS23995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0853_RS24000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0853_RS24005	COG3340	Belongs to the peptidase S51 family
D0853_RS24025	COG1444	tRNA N-acetyltransferase activity
D0853_RS24050	COG4608	Belongs to the ABC transporter superfamily
D0853_RS24055	COG0444	Belongs to the ABC transporter superfamily
D0853_RS24065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0853_RS24065	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
D0853_RS24090	COG0217	transcriptional regulatory protein
D0853_RS24095	COG0772	Belongs to the SEDS family
D0853_RS24110	COG1136	(ABC) transporter
D0853_RS24130	COG3275	phosphorelay sensor kinase activity
D0853_RS24135	COG3279	Response regulator of the LytR AlgR family
D0853_RS24145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0853_RS24180	COG0786	glutamate:sodium symporter activity
D0853_RS24190	COG1131	(ABC) transporter
D0853_RS24195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0853_RS24200	COG0786	glutamate:sodium symporter activity
D0853_RS24215	COG0363	glucosamine-6-phosphate deaminase activity
D0853_RS24235	COG1741	Belongs to the pirin family
D0853_RS24240	COG2259	Doxx family
D0853_RS24255	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D0853_RS24260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0853_RS24270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0853_RS24310	COG3123	guanosine phosphorylase activity
D0853_RS24320	COG5001	Diguanylate cyclase
D0853_RS24330	COG0534	Mate efflux family protein
D0853_RS24335	COG0564	pseudouridine synthase activity
D0853_RS24350	COG0583	DNA-binding transcription factor activity
D0853_RS24355	COG0561	phosphatase activity
D0853_RS24365	COG2199	diguanylate cyclase activity
D0853_RS24380	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D0853_RS24385	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D0853_RS24390	COG0583	DNA-binding transcription factor activity
D0853_RS24405	COG1414	Transcriptional regulator
D0853_RS24410	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS24420	COG1917	Cupin 2, conserved barrel domain protein
D0853_RS24435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0853_RS24440	COG0800	Aldolase
D0853_RS24460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0853_RS24465	COG0823	Involved in the tonB-independent uptake of proteins
D0853_RS24470	COG2375	cellular response to nickel ion
D0853_RS24500	COG1357	PFAM Pentapeptide repeats (8 copies)
D0853_RS24505	COG3047	cAMP biosynthetic process
D0853_RS24535	COG3408	Glycogen debranching enzyme
D0853_RS24535	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D0853_RS24540	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D0853_RS24550	COG0583	DNA-binding transcription factor activity
D0853_RS24560	COG0583	DNA-binding transcription factor activity
D0853_RS24575	COG0546	phosphoglycolate phosphatase activity
D0853_RS24600	COG3835	regulator
D0853_RS24605	COG2610	gluconate transmembrane transporter activity
D0853_RS24610	COG1929	Belongs to the glycerate kinase type-1 family
D0853_RS24615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0853_RS24635	COG0456	acetyltransferase
D0853_RS24650	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_RS24660	COG3005	denitrification pathway
D0853_RS24665	COG0243	molybdopterin cofactor binding
D0853_RS24675	COG0352	thiamine-phosphate diphosphorylase activity
D0853_RS24680	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D0853_RS24685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D0853_RS24690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0853_RS24695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0853_RS24700	COG1116	anion transmembrane transporter activity
D0853_RS24705	COG0351	phosphomethylpyrimidine kinase
D0853_RS24715	COG0312	modulator of DNA gyrase
D0853_RS24720	COG0312	modulator of DNA gyrase
D0853_RS24725	COG1901	pseudouridine methyltransferase
D0853_RS24785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0853_RS24795	COG0584	glycerophosphoryl diester phosphodiesterase
D0853_RS24800	COG0039	L-malate dehydrogenase activity
D0853_RS24805	COG0745	RESPONSE REGULATOR receiver
D0853_RS24825	COG0811	peptide transport
D0853_RS24830	COG0811	peptide transport
D0853_RS24835	COG0848	biopolymer transport protein
D0853_RS24875	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0853_RS24880	COG1121	(ABC) transporter
D0853_RS24885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0853_RS24900	COG1770	oligopeptidase
D0853_RS24905	COG2814	Major facilitator Superfamily
D0853_RS24910	COG0010	Belongs to the arginase family
D0853_RS24915	COG1166	arginine decarboxylase activity
D0853_RS24925	COG4067	protein conserved in archaea
D0853_RS24925	COG0189	ligase activity
D0853_RS24930	COG0189	ligase activity
D0853_RS24940	COG0583	DNA-binding transcription factor activity
D0853_RS24985	COG3706	GGDEF domain
D0853_RS24990	COG1114	Component of the transport system for branched-chain amino acids
D0853_RS25015	COG0579	oxidoreductase
D0853_RS25025	COG3033	Beta-eliminating lyase
D0853_RS25045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0853_RS25060	COG3706	GGDEF domain
D0853_RS25065	COG0840	transmembrane signaling receptor activity
D0853_RS25080	COG3706	GGDEF domain
D0853_RS25085	COG0415	Belongs to the DNA photolyase family
D0853_RS25090	COG3046	protein related to deoxyribodipyrimidine photolyase
D0853_RS25105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0853_RS25105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0853_RS25110	COG1765	OsmC-like protein
D0853_RS25115	COG0110	maltose O-acetyltransferase activity
D0853_RS25155	COG1011	Hydrolase
D0853_RS25170	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D0853_RS25180	COG2067	long-chain fatty acid transport protein
D0853_RS25185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_RS25190	COG1136	(ABC) transporter
D0853_RS25190	COG0577	efflux transmembrane transporter activity
D0853_RS25200	COG3240	lipase activity
D0853_RS25230	COG1609	Transcriptional regulator
D0853_RS25235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0853_RS25240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0853_RS25245	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0853_RS25250	COG1840	ABC-type Fe3 transport system, periplasmic component
D0853_RS25260	COG3842	ATPase activity
D0853_RS25285	COG2990	Protein conserved in bacteria
D0853_RS25295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0853_RS25300	COG2866	Carboxypeptidase
D0853_RS25315	COG0583	DNA-binding transcription factor activity
D0853_RS25335	COG3104	oligopeptide transport
D0853_RS25340	COG1760	l-serine dehydratase
D0853_RS25360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D0853_RS25370	COG0741	lytic transglycosylase activity
D0853_RS25390	COG1815	bacterial-type flagellum-dependent cell motility
D0853_RS25395	COG1558	bacterial-type flagellum-dependent cell motility
D0853_RS25400	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0853_RS25405	COG1749	Flagellar hook protein flgE
D0853_RS25410	COG4787	bacterial-type flagellum-dependent cell motility
D0853_RS25415	COG4786	Flagellar basal body rod
D0853_RS25420	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0853_RS25425	COG1706	bacterial-type flagellum-dependent cell motility
D0853_RS25435	COG4786	Flagellar basal body rod
D0853_RS25435	COG1256	bacterial-type flagellum assembly
D0853_RS25440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_RS25460	COG1304	FMN binding
D0853_RS25490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0853_RS25500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D0853_RS25505	COG0459	protein refolding
D0853_RS25520	COG1280	lysine exporter protein (LysE YggA)
D0853_RS25540	COG1309	transcriptional regulator
D0853_RS25550	COG0737	Belongs to the 5'-nucleotidase family
D0853_RS25555	COG2070	2-Nitropropane dioxygenase
D0853_RS25560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_RS25570	COG0583	DNA-binding transcription factor activity
D0853_RS25585	COG0346	lactoylglutathione lyase activity
D0853_RS25590	COG1349	DNA-binding transcription factor activity