locus-tag	class	description
FKM99_RS00010	COG0444	Belongs to the ABC transporter superfamily
FKM99_RS00015	COG4608	Belongs to the ABC transporter superfamily
FKM99_RS00040	COG1444	tRNA N-acetyltransferase activity
FKM99_RS00060	COG3340	Belongs to the peptidase S51 family
FKM99_RS00065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FKM99_RS00070	COG1263	PTS System
FKM99_RS00070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FKM99_RS00075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FKM99_RS00095	COG4166	transmembrane transport
FKM99_RS00140	COG0259	pyridoxamine-phosphate oxidase activity
FKM99_RS00170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FKM99_RS00215	COG1132	(ABC) transporter
FKM99_RS00225	COG2207	Transcriptional regulator
FKM99_RS00250	COG0800	Aldolase
FKM99_RS00255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FKM99_RS00260	COG1904	glucuronate isomerase
FKM99_RS00265	COG0246	Mannitol dehydrogenase
FKM99_RS00275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FKM99_RS00285	COG2186	Transcriptional regulator
FKM99_RS00290	COG1312	Catalyzes the dehydration of D-mannonate
FKM99_RS00295	COG0513	Belongs to the DEAD box helicase family
FKM99_RS00300	COG2258	MOSC domain
FKM99_RS00315	COG1486	melibiose metabolic process
FKM99_RS00320	COG0583	DNA-binding transcription factor activity
FKM99_RS00340	COG1595	DNA-templated transcription, initiation
FKM99_RS00380	COG3634	alkyl hydroperoxide reductase activity
FKM99_RS00390	COG1846	Transcriptional regulator
FKM99_RS00395	COG1764	response to oxidative stress
FKM99_RS00420	COG2160	L-arabinose isomerase activity
FKM99_RS00430	COG1069	ribulokinase activity
FKM99_RS00435	COG1879	ABC-type sugar transport system periplasmic component
FKM99_RS00440	COG1129	ABC transporter
FKM99_RS00445	COG1172	Belongs to the binding-protein-dependent transport system permease family
FKM99_RS00450	COG0826	peptidase U32
FKM99_RS00480	COG1653	transport
FKM99_RS00485	COG0019	diaminopimelate decarboxylase activity
FKM99_RS00490	COG4264	IucA IucC family
FKM99_RS00495	COG2814	Major facilitator Superfamily
FKM99_RS00515	COG4772	TonB-dependent receptor
FKM99_RS00520	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FKM99_RS00525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FKM99_RS00530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FKM99_RS00535	COG1120	ATPase activity
FKM99_RS00540	COG0840	transmembrane signaling receptor activity
FKM99_RS00545	COG0612	Peptidase, M16
FKM99_RS00555	COG0739	heme binding
FKM99_RS00565	COG2814	Major facilitator Superfamily
FKM99_RS00605	COG2356	endonuclease I
FKM99_RS00625	COG1982	Orn Lys Arg decarboxylase major
FKM99_RS00630	COG0531	amino acid
FKM99_RS00640	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FKM99_RS00650	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FKM99_RS00655	COG1162	GTPase activity
FKM99_RS00660	COG1263	PTS System
FKM99_RS00660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FKM99_RS00670	COG1999	signal sequence binding
FKM99_RS00685	COG2909	trisaccharide binding
FKM99_RS00700	COG0058	SHG alpha-glucan phosphorylase activity
FKM99_RS00705	COG1640	4-alpha-glucanotransferase
FKM99_RS00710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FKM99_RS00840	COG0484	heat shock protein binding
FKM99_RS00995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FKM99_RS01000	COG0366	Alpha amylase catalytic
FKM99_RS01015	COG3366	ferrous iron transmembrane transporter activity
FKM99_RS01020	COG0700	Nucleoside recognition
FKM99_RS01025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FKM99_RS01030	COG3339	Conserved Protein
FKM99_RS01035	COG1301	dicarboxylic acid transport
FKM99_RS01045	COG0583	DNA-binding transcription factor activity
FKM99_RS01065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FKM99_RS01070	COG1596	polysaccharide export
FKM99_RS01085	COG2095	MarC family integral membrane protein
FKM99_RS01090	COG4667	esterase of the alpha-beta hydrolase superfamily
FKM99_RS01095	COG3397	chitin binding
FKM99_RS01100	COG1054	Belongs to the UPF0176 family
FKM99_RS01115	COG1686	Belongs to the peptidase S11 family
FKM99_RS01140	COG0583	DNA-binding transcription factor activity
FKM99_RS01145	COG4628	conserved protein (DUF2132)
FKM99_RS01155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FKM99_RS01165	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FKM99_RS01170	COG0628	permease
FKM99_RS01215	COG2814	Major facilitator Superfamily
FKM99_RS01225	COG0454	-acetyltransferase
FKM99_RS01235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FKM99_RS01240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FKM99_RS01245	COG1882	Formate acetyltransferase
FKM99_RS01295	COG1360	Flagellar Motor Protein
FKM99_RS01300	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FKM99_RS01305	COG1191	sigma factor activity
FKM99_RS01310	COG1580	Controls the rotational direction of flagella during chemotaxis
FKM99_RS01325	COG1516	flagellar protein fliS
FKM99_RS01330	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FKM99_RS01340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FKM99_RS01355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FKM99_RS01365	COG1987	bacterial-type flagellum assembly
FKM99_RS01445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FKM99_RS01465	COG0346	lactoylglutathione lyase activity
FKM99_RS01500	COG0745	RESPONSE REGULATOR receiver
FKM99_RS01520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FKM99_RS01530	COG0156	8-amino-7-oxononanoate synthase activity
FKM99_RS01535	COG1063	alcohol dehydrogenase
FKM99_RS01570	COG0668	transmembrane transport
FKM99_RS01580	COG1304	FMN binding
FKM99_RS01585	COG1620	l-lactate permease
FKM99_RS01590	COG0583	DNA-binding transcription factor activity
FKM99_RS01595	COG1505	serine-type exopeptidase activity
FKM99_RS01600	COG4172	Belongs to the ABC transporter superfamily
FKM99_RS01610	COG1067	ATP-dependent peptidase activity
FKM99_RS01640	COG1247	-acetyltransferase
FKM99_RS01645	COG0437	4 iron, 4 sulfur cluster binding
FKM99_RS01650	COG0348	domain, Protein
FKM99_RS01665	COG1122	ATPase activity
FKM99_RS01670	COG4720	Psort location CytoplasmicMembrane, score
FKM99_RS01675	COG1566	PFAM secretion protein HlyD family protein
FKM99_RS01685	COG3706	GGDEF domain
FKM99_RS01700	COG0813	purine-nucleoside phosphorylase activity
FKM99_RS01710	COG3272	Protein of unknown function (DUF1722)
FKM99_RS01715	COG0789	Transcriptional regulator
FKM99_RS01720	COG0415	Belongs to the DNA photolyase family
FKM99_RS01725	COG1388	LysM domain
FKM99_RS01725	COG1376	ErfK ybiS ycfS ynhG family protein
FKM99_RS01735	COG0513	Belongs to the DEAD box helicase family
FKM99_RS01740	COG1770	oligopeptidase
FKM99_RS01745	COG4771	TonB-dependent receptor
FKM99_RS01775	COG0573	inorganic phosphate transmembrane transporter activity
FKM99_RS01780	COG0581	inorganic phosphate transmembrane transporter activity
FKM99_RS01785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FKM99_RS01800	COG2304	oxidoreductase activity
FKM99_RS01820	COG0714	Associated with various cellular activities
FKM99_RS01830	COG0840	transmembrane signaling receptor activity
FKM99_RS01890	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FKM99_RS01895	COG1120	ATPase activity
FKM99_RS01900	COG4774	siderophore transport
FKM99_RS01905	COG1132	(ABC) transporter
FKM99_RS01910	COG2205	protein histidine kinase activity
FKM99_RS01920	COG0569	domain protein
FKM99_RS01925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FKM99_RS01935	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FKM99_RS01940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FKM99_RS01955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FKM99_RS01955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FKM99_RS01955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FKM99_RS01960	COG2207	Transcriptional regulator
FKM99_RS01970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FKM99_RS01975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FKM99_RS01980	COG2084	Dehydrogenase
FKM99_RS01985	COG0753	catalase activity
FKM99_RS01995	COG2130	NADP-dependent
FKM99_RS02000	COG1309	transcriptional regulator
FKM99_RS02005	COG3097	Belongs to the UPF0267 family
FKM99_RS02065	COG3842	ATPase activity
FKM99_RS02075	COG1175	transmembrane transport
FKM99_RS02080	COG3833	ABC-type maltose transport systems, permease component
FKM99_RS02110	COG2354	Protein conserved in bacteria
FKM99_RS02115	COG0418	dihydroorotase activity
FKM99_RS02125	COG0401	homolog of Blt101
FKM99_RS02135	COG3217	Mosc domain protein beta barrel domain protein
FKM99_RS02135	COG0633	Ferredoxin
FKM99_RS02135	COG3217	Mosc domain protein beta barrel domain protein
FKM99_RS02135	COG0633	Ferredoxin
FKM99_RS02140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FKM99_RS02145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FKM99_RS02190	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FKM99_RS02195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FKM99_RS02205	COG0848	biopolymer transport protein
FKM99_RS02210	COG0811	peptide transport
FKM99_RS02215	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FKM99_RS02225	COG3721	Heme iron utilization protein
FKM99_RS02230	COG0748	coenzyme F420 binding
FKM99_RS02240	COG0835	chemotaxis
FKM99_RS02240	COG0784	Response regulator, receiver
FKM99_RS02250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FKM99_RS02275	COG1201	RNA secondary structure unwinding
FKM99_RS02300	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FKM99_RS02305	COG0783	Belongs to the Dps family
FKM99_RS02315	COG0583	DNA-binding transcription factor activity
FKM99_RS02330	COG4934	collagen metabolic process
FKM99_RS02340	COG0366	Alpha amylase catalytic
FKM99_RS02360	COG2249	NAD(P)H dehydrogenase (quinone) activity
FKM99_RS02365	COG0589	response to stress
FKM99_RS02370	COG0488	(ABC) transporter
FKM99_RS02375	COG1505	serine-type exopeptidase activity
FKM99_RS02385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKM99_RS02395	COG2067	long-chain fatty acid transport protein
FKM99_RS02405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FKM99_RS02435	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKM99_RS02460	COG3383	formate dehydrogenase (NAD+) activity
FKM99_RS02475	COG0842	Transport permease protein
FKM99_RS02480	COG1131	(ABC) transporter
FKM99_RS02500	COG2706	6-phosphogluconolactonase activity
FKM99_RS02510	COG1881	PFAM PEBP family protein
FKM99_RS02520	COG0798	PFAM Bile acid sodium symporter
FKM99_RS02540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FKM99_RS02545	COG2213	PTS system mannitol-specific
FKM99_RS02550	COG1063	alcohol dehydrogenase
FKM99_RS02560	COG1072	(Pantothenic acid kinase))
FKM99_RS02565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FKM99_RS02585	COG0814	amino acid
FKM99_RS02600	COG3314	Sporulation integral membrane protein YlbJ
FKM99_RS02625	COG0739	heme binding
FKM99_RS02630	COG5001	Diguanylate cyclase
FKM99_RS02635	COG0583	DNA-binding transcription factor activity
FKM99_RS02640	COG2814	Major facilitator Superfamily
FKM99_RS02665	COG0697	spore germination
FKM99_RS02695	COG2207	Transcriptional regulator
FKM99_RS02700	COG1280	lysine exporter protein (LysE YggA)
FKM99_RS02710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FKM99_RS02715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FKM99_RS02725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FKM99_RS02750	COG1612	heme a metabolic process
FKM99_RS02755	COG0109	protoheme IX farnesyltransferase activity
FKM99_RS02760	COG0545	Peptidyl-prolyl cis-trans isomerase
FKM99_RS02795	COG1278	Cold shock
FKM99_RS02800	COG3036	rescue of stalled ribosome
FKM99_RS02815	COG2199	diguanylate cyclase activity
FKM99_RS02835	COG1136	(ABC) transporter
FKM99_RS02835	COG0577	efflux transmembrane transporter activity
FKM99_RS02845	COG0840	transmembrane signaling receptor activity
FKM99_RS02850	COG0783	Belongs to the Dps family
FKM99_RS02860	COG2133	pyrroloquinoline quinone binding
FKM99_RS02865	COG1454	alcohol dehydrogenase
FKM99_RS02870	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FKM99_RS02905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FKM99_RS02910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FKM99_RS02915	COG3186	Phenylalanine-4-hydroxylase
FKM99_RS02920	COG2154	pterin-4-alpha-carbinolamine dehydratase
FKM99_RS02945	COG3530	Putative quorum-sensing-regulated virulence factor
FKM99_RS02950	COG0513	Belongs to the DEAD box helicase family
FKM99_RS02955	COG4628	conserved protein (DUF2132)
FKM99_RS02960	COG0133	tryptophan synthase activity
FKM99_RS02970	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FKM99_RS02980	COG0523	cobalamin synthesis protein
FKM99_RS02985	COG0513	Belongs to the DEAD box helicase family
FKM99_RS03005	COG2200	EAL domain
FKM99_RS03010	COG1119	ATPase activity
FKM99_RS03015	COG0840	transmembrane signaling receptor activity
FKM99_RS03040	COG0641	radical SAM
FKM99_RS03060	COG2815	serine threonine protein kinase
FKM99_RS03060	COG0515	serine threonine protein kinase
FKM99_RS03065	COG0515	serine threonine protein kinase
FKM99_RS03095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FKM99_RS03110	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FKM99_RS03115	COG0513	Belongs to the DEAD box helicase family
FKM99_RS03120	COG5001	Diguanylate cyclase
FKM99_RS03130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FKM99_RS03145	COG5413	integral membrane protein
FKM99_RS03155	COG1024	Enoyl-CoA hydratase
FKM99_RS03160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FKM99_RS03165	COG1960	acyl-CoA dehydrogenase activity
FKM99_RS03175	COG0183	Belongs to the thiolase family
FKM99_RS03190	COG1024	Enoyl-CoA hydratase
FKM99_RS03195	COG1024	Enoyl-CoA hydratase
FKM99_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
FKM99_RS03210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FKM99_RS03215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FKM99_RS03220	COG1845	cytochrome c oxidase, subunit III
FKM99_RS03225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FKM99_RS03230	COG0109	protoheme IX farnesyltransferase activity
FKM99_RS03245	COG1902	pentaerythritol trinitrate reductase activity
FKM99_RS03280	COG1126	abc transporter atp-binding protein
FKM99_RS03285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FKM99_RS03290	COG4215	(ABC) transporter
FKM99_RS03295	COG4160	amino acid transport
FKM99_RS03310	COG0625	glutathione transferase activity
FKM99_RS03345	COG0443	Heat shock 70 kDa protein
FKM99_RS03350	COG2847	Copper chaperone PCu(A)C
FKM99_RS03380	COG0745	RESPONSE REGULATOR receiver
FKM99_RS03425	COG0814	amino acid
FKM99_RS03435	COG0243	molybdopterin cofactor binding
FKM99_RS03460	COG3707	response regulator
FKM99_RS03470	COG1116	anion transmembrane transporter activity
FKM99_RS03470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FKM99_RS03475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FKM99_RS03480	COG1116	anion transmembrane transporter activity
FKM99_RS03485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FKM99_RS03485	COG2146	nitrite reductase [NAD(P)H] activity
FKM99_RS03540	COG0515	serine threonine protein kinase
FKM99_RS03540	COG2815	serine threonine protein kinase
FKM99_RS03575	COG0631	protein serine/threonine phosphatase activity
FKM99_RS03645	COG0420	3'-5' exonuclease activity
FKM99_RS03650	COG0419	ATPase involved in DNA repair
FKM99_RS03655	COG3328	transposase activity
FKM99_RS03675	COG3040	lipid binding
FKM99_RS03685	COG2814	Major facilitator Superfamily
FKM99_RS03695	COG1288	antiporter activity
FKM99_RS03710	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FKM99_RS03725	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FKM99_RS03745	COG0583	DNA-binding transcription factor activity
FKM99_RS03750	COG0277	FAD linked oxidase domain protein
FKM99_RS03770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FKM99_RS03855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FKM99_RS03860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FKM99_RS03870	COG2116	formate transmembrane transporter activity
FKM99_RS03890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FKM99_RS03925	COG0534	Mate efflux family protein
FKM99_RS03930	COG2205	protein histidine kinase activity
FKM99_RS03930	COG3292	Two component regulator propeller
FKM99_RS03930	COG0745	RESPONSE REGULATOR receiver
FKM99_RS03940	COG3118	belongs to the thioredoxin family
FKM99_RS03945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FKM99_RS03970	COG2271	Major facilitator Superfamily
FKM99_RS03975	COG3851	Histidine kinase
FKM99_RS03980	COG2197	response regulator
FKM99_RS03990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FKM99_RS03995	COG0583	DNA-binding transcription factor activity
FKM99_RS04005	COG0243	molybdopterin cofactor binding
FKM99_RS04035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKM99_RS04050	COG1328	CTP reductase activity
FKM99_RS04055	COG0602	queuosine metabolic process
FKM99_RS04060	COG0534	Mate efflux family protein
FKM99_RS04080	COG4067	protein conserved in archaea
FKM99_RS04080	COG0189	ligase activity
FKM99_RS04090	COG3111	PFAM Bacterial OB fold (BOF) protein
FKM99_RS04095	COG1492	cobalamin metabolic process
FKM99_RS04100	COG0725	ABC transporter, periplasmic molybdate-binding protein
FKM99_RS04105	COG4149	molybdate abc transporter
FKM99_RS04110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FKM99_RS04120	COG2203	Gaf domain
FKM99_RS04120	COG5001	Diguanylate cyclase
FKM99_RS04120	COG4251	negative regulation of phosphorylation
FKM99_RS04120	COG3706	GGDEF domain
FKM99_RS04145	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FKM99_RS04150	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FKM99_RS04175	COG3140	Belongs to the UPF0181 family
FKM99_RS04180	COG0589	response to stress
FKM99_RS04210	COG0023	Translation Initiation Factor
FKM99_RS04220	COG1181	Belongs to the D-alanine--D-alanine ligase family
FKM99_RS04230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FKM99_RS04230	COG1042	CoA-binding domain protein
FKM99_RS04230	COG0045	succinate-CoA ligase (ADP-forming) activity
FKM99_RS04235	COG0583	DNA-binding transcription factor activity
FKM99_RS04240	COG4771	TonB-dependent receptor
FKM99_RS04240	COG1629	transport
FKM99_RS04250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FKM99_RS04255	COG3447	MASE1 domain protein
FKM99_RS04255	COG5001	Diguanylate cyclase
FKM99_RS04255	COG5002	protein histidine kinase activity
FKM99_RS04260	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FKM99_RS04265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FKM99_RS04270	COG1984	allophanate hydrolase subunit 2
FKM99_RS04280	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FKM99_RS04285	COG4181	ATPase activity
FKM99_RS04295	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FKM99_RS04300	COG5001	Diguanylate cyclase
FKM99_RS04300	COG3300	MHYT domain
FKM99_RS04310	COG0484	heat shock protein binding
FKM99_RS04335	COG4533	DNA binding
FKM99_RS04345	COG2050	protein possibly involved in aromatic compounds catabolism
FKM99_RS04360	COG2067	long-chain fatty acid transport protein
FKM99_RS04365	COG2267	carboxylic ester hydrolase activity
FKM99_RS04380	COG0861	Integral membrane protein TerC family
FKM99_RS04385	COG0737	Belongs to the 5'-nucleotidase family
FKM99_RS04390	COG3593	DNA synthesis involved in DNA repair
FKM99_RS04400	COG0583	DNA-binding transcription factor activity
FKM99_RS04405	COG2116	formate transmembrane transporter activity
FKM99_RS04410	COG2353	YceI-like domain
FKM99_RS04415	COG3038	cytochrome b561
FKM99_RS04430	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FKM99_RS04435	COG0513	Belongs to the DEAD box helicase family
FKM99_RS04440	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FKM99_RS04450	COG0840	transmembrane signaling receptor activity
FKM99_RS04460	COG0546	phosphoglycolate phosphatase activity
FKM99_RS04470	COG0784	Response regulator, receiver
FKM99_RS04470	COG3437	response regulator, receiver
FKM99_RS04490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FKM99_RS04495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FKM99_RS04500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FKM99_RS04515	COG2207	Transcriptional regulator
FKM99_RS04520	COG1979	alcohol dehydrogenase
FKM99_RS04545	COG2271	Major facilitator Superfamily
FKM99_RS04550	COG0469	pyruvate kinase activity
FKM99_RS04555	COG1126	abc transporter atp-binding protein
FKM99_RS04560	COG0765	amino acid transport
FKM99_RS04565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FKM99_RS04570	COG0765	amino acid transport
FKM99_RS04575	COG2199	diguanylate cyclase activity
FKM99_RS04575	COG2200	EAL domain
FKM99_RS04575	COG2203	Gaf domain
FKM99_RS04595	COG1609	Transcriptional regulator
FKM99_RS04600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FKM99_RS04600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FKM99_RS04605	COG1105	Belongs to the carbohydrate kinase PfkB family
FKM99_RS04610	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FKM99_RS04610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FKM99_RS04610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FKM99_RS04650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FKM99_RS04655	COG0509	glycine decarboxylation via glycine cleavage system
FKM99_RS04660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FKM99_RS04660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FKM99_RS04665	COG0210	DNA helicase
FKM99_RS04720	COG1078	dGTPase activity
FKM99_RS04750	COG4584	PFAM Integrase catalytic
FKM99_RS04755	COG1484	DNA-dependent DNA replication
FKM99_RS04790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FKM99_RS04795	COG0583	DNA-binding transcription factor activity
FKM99_RS04850	COG0242	peptide deformylase activity
FKM99_RS04880	COG2239	Acts as a magnesium transporter
FKM99_RS04900	COG0346	lactoylglutathione lyase activity
FKM99_RS04905	COG1902	pentaerythritol trinitrate reductase activity
FKM99_RS04925	COG5642	Protein of unknown function (DUF2384)
FKM99_RS04930	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FKM99_RS04950	COG4565	transcriptional regulatory protein
FKM99_RS04955	COG3290	protein histidine kinase activity
FKM99_RS04960	COG0471	metal ion transport
FKM99_RS04990	COG2076	Multidrug Resistance protein
FKM99_RS05005	COG0671	phosphoesterase, PA-phosphatase related
FKM99_RS05020	COG2962	Rard protein
FKM99_RS05040	COG0784	Response regulator, receiver
FKM99_RS05040	COG0835	chemotaxis
FKM99_RS05065	COG2197	response regulator
FKM99_RS05075	COG3706	GGDEF domain
FKM99_RS05080	COG2197	response regulator
FKM99_RS05085	COG3300	MHYT domain
FKM99_RS05085	COG5001	Diguanylate cyclase
FKM99_RS05100	COG0583	DNA-binding transcription factor activity
FKM99_RS05105	COG0583	DNA-binding transcription factor activity
FKM99_RS05165	COG4964	Belongs to the GSP D family
FKM99_RS05190	COG2207	Transcriptional regulator
FKM99_RS05200	COG4934	collagen metabolic process
FKM99_RS05210	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FKM99_RS05230	COG0456	acetyltransferase
FKM99_RS05230	COG1214	PFAM Peptidase M22, glycoprotease
FKM99_RS05240	COG3069	C4-dicarboxylate transmembrane transporter activity
FKM99_RS05245	COG1704	LemA family
FKM99_RS05250	COG0501	Belongs to the peptidase M48B family
FKM99_RS05280	COG0641	radical SAM
FKM99_RS05300	COG3111	PFAM Bacterial OB fold (BOF) protein
FKM99_RS05305	COG1597	lipid kinase activity
FKM99_RS05310	COG0583	DNA-binding transcription factor activity
FKM99_RS05315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FKM99_RS05345	COG0714	Associated with various cellular activities
FKM99_RS05350	COG0641	radical SAM
FKM99_RS05355	COG3119	arylsulfatase activity
FKM99_RS05370	COG3119	arylsulfatase activity
FKM99_RS05375	COG3119	arylsulfatase activity
FKM99_RS05380	COG0745	RESPONSE REGULATOR receiver
FKM99_RS05395	COG2198	Histidine kinase
FKM99_RS05395	COG2205	protein histidine kinase activity
FKM99_RS05395	COG0784	Response regulator, receiver
FKM99_RS05400	COG1879	ABC-type sugar transport system periplasmic component
FKM99_RS05405	COG1803	Methylglyoxal synthase
FKM99_RS05410	COG0210	DNA helicase
FKM99_RS05415	COG1289	transmembrane transporter activity
FKM99_RS05450	COG1629	transport
FKM99_RS05450	COG4771	TonB-dependent receptor
FKM99_RS05465	COG0789	Transcriptional regulator
FKM99_RS05470	COG4604	ABC transporter, ATP-binding protein
FKM99_RS05475	COG4605	iron ion homeostasis
FKM99_RS05480	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FKM99_RS05485	COG4607	ABC-type enterochelin transport system periplasmic component
FKM99_RS05495	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FKM99_RS05510	COG1609	Transcriptional regulator
FKM99_RS05515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FKM99_RS05520	COG1879	ABC-type sugar transport system periplasmic component
FKM99_RS05525	COG1172	Belongs to the binding-protein-dependent transport system permease family
FKM99_RS05530	COG1129	ABC transporter
FKM99_RS05535	COG1869	D-ribose catabolic process
FKM99_RS05540	COG5001	Diguanylate cyclase
FKM99_RS05545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FKM99_RS05605	COG0784	Response regulator, receiver
FKM99_RS05605	COG2205	protein histidine kinase activity
FKM99_RS05625	COG5001	Diguanylate cyclase
FKM99_RS05625	COG3300	MHYT domain
FKM99_RS05635	COG0330	HflC and HflK could
FKM99_RS05650	COG4175	Glycine betaine
FKM99_RS05650	COG0517	IMP dehydrogenase activity
FKM99_RS05655	COG4176	ABC-type proline glycine betaine transport system permease component
FKM99_RS05670	COG1012	belongs to the aldehyde dehydrogenase family
FKM99_RS05675	COG1309	transcriptional regulator
FKM99_RS05680	COG3706	GGDEF domain
FKM99_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
FKM99_RS05705	COG1024	Enoyl-CoA hydratase
FKM99_RS05710	COG1960	acyl-CoA dehydrogenase activity
FKM99_RS05720	COG0183	Belongs to the thiolase family
FKM99_RS05730	COG1960	acyl-CoA dehydrogenase activity
FKM99_RS05735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FKM99_RS05755	COG3437	response regulator, receiver
FKM99_RS05755	COG2205	protein histidine kinase activity
FKM99_RS05755	COG4999	Histidine kinase
FKM99_RS05755	COG3850	Histidine kinase
FKM99_RS05770	COG3264	Mechanosensitive ion channel
FKM99_RS05770	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FKM99_RS05780	COG0110	maltose O-acetyltransferase activity
FKM99_RS05785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FKM99_RS05790	COG1271	oxidase subunit
FKM99_RS05795	COG1294	oxidase, subunit
FKM99_RS05805	COG0384	phenazine biosynthesis protein PhzF
FKM99_RS05810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FKM99_RS05815	COG0789	Transcriptional regulator
FKM99_RS05825	COG3474	cytochrome
FKM99_RS05895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FKM99_RS05900	COG0516	GMP reductase activity
FKM99_RS05905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FKM99_RS05905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FKM99_RS05920	COG4989	oxidoreductase activity
FKM99_RS05935	COG0038	chloride channel
FKM99_RS05945	COG1914	H( )-stimulated, divalent metal cation uptake system
FKM99_RS05950	COG0302	gtp cyclohydrolase
FKM99_RS05960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FKM99_RS05980	COG2897	thiosulfate sulfurtransferase activity
FKM99_RS06010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FKM99_RS06015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FKM99_RS06020	COG0840	transmembrane signaling receptor activity
FKM99_RS06030	COG2814	Major facilitator Superfamily
FKM99_RS06035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FKM99_RS06050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FKM99_RS06060	COG0840	transmembrane signaling receptor activity
FKM99_RS06080	COG2195	Cleaves the N-terminal amino acid of tripeptides
FKM99_RS06095	COG2197	response regulator
FKM99_RS06100	COG3850	Histidine kinase
FKM99_RS06105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FKM99_RS06115	COG0243	molybdopterin cofactor binding
FKM99_RS06125	COG3005	denitrification pathway
FKM99_RS06145	COG0183	Belongs to the thiolase family
FKM99_RS06155	COG1280	lysine exporter protein (LysE YggA)
FKM99_RS06165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FKM99_RS06170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FKM99_RS06200	COG1522	sequence-specific DNA binding
FKM99_RS06220	COG1566	PFAM secretion protein HlyD family protein
FKM99_RS06230	COG0784	Response regulator, receiver
FKM99_RS06230	COG2205	protein histidine kinase activity
FKM99_RS06235	COG1879	ABC-type sugar transport system periplasmic component
FKM99_RS06240	COG2827	Endonuclease containing a URI domain
FKM99_RS06245	COG3132	Protein of unknown function, DUF480
FKM99_RS06260	COG2926	Belongs to the UPF0265 family
FKM99_RS06265	COG0534	Mate efflux family protein
FKM99_RS06270	COG0673	inositol 2-dehydrogenase activity
FKM99_RS06275	COG0784	Response regulator, receiver
FKM99_RS06275	COG2205	protein histidine kinase activity
FKM99_RS06275	COG5002	protein histidine kinase activity
FKM99_RS06305	COG1522	sequence-specific DNA binding
FKM99_RS06315	COG0531	amino acid
FKM99_RS06330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FKM99_RS06335	COG2239	Acts as a magnesium transporter
FKM99_RS06345	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FKM99_RS06350	COG0402	S-adenosylhomocysteine deaminase activity
FKM99_RS06360	COG1418	mRNA catabolic process
FKM99_RS06375	COG2814	Major facilitator Superfamily
FKM99_RS06385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FKM99_RS06405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FKM99_RS06425	COG4221	oxidoreductase activity
FKM99_RS06430	COG0745	RESPONSE REGULATOR receiver
FKM99_RS06435	COG2205	protein histidine kinase activity
FKM99_RS06445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FKM99_RS06450	COG2194	sulfuric ester hydrolase activity
FKM99_RS06455	COG0673	inositol 2-dehydrogenase activity
FKM99_RS06490	COG4667	esterase of the alpha-beta hydrolase superfamily
FKM99_RS06495	COG1741	Belongs to the pirin family
FKM99_RS06500	COG1278	Cold shock
FKM99_RS06520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FKM99_RS06525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FKM99_RS06525	COG0678	peroxiredoxin activity
FKM99_RS06540	COG1686	Belongs to the peptidase S11 family
FKM99_RS06555	COG0625	glutathione transferase activity
FKM99_RS06565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FKM99_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
FKM99_RS06605	COG3746	phosphate-selective porin O and P
FKM99_RS06625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FKM99_RS06625	COG2207	Transcriptional regulator
FKM99_RS06630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FKM99_RS06660	COG0513	Belongs to the DEAD box helicase family
FKM99_RS06670	COG0583	DNA-binding transcription factor activity
FKM99_RS06685	COG1902	pentaerythritol trinitrate reductase activity
FKM99_RS06700	COG1028	Short-chain dehydrogenase reductase Sdr
FKM99_RS06715	COG3122	Protein conserved in bacteria
FKM99_RS06730	COG0583	DNA-binding transcription factor activity
FKM99_RS06735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FKM99_RS06740	COG0252	asparaginase activity
FKM99_RS06745	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FKM99_RS06750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FKM99_RS06750	COG0574	Belongs to the PEP-utilizing enzyme family
FKM99_RS06770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FKM99_RS06790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKM99_RS06810	COG3706	GGDEF domain
FKM99_RS06830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FKM99_RS06860	COG3842	ATPase activity
FKM99_RS06915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FKM99_RS06960	COG0583	DNA-binding transcription factor activity
FKM99_RS06970	COG4948	Mandelate Racemase Muconate Lactonizing
FKM99_RS07005	COG1342	Belongs to the UPF0251 family
FKM99_RS07015	COG3015	lipoprotein NlpE involved in copper resistance
FKM99_RS07025	COG3713	MltA-interacting MipA family protein
FKM99_RS07040	COG0583	DNA-binding transcription factor activity
FKM99_RS07070	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FKM99_RS07080	COG1335	isochorismatase
FKM99_RS07090	COG0753	catalase activity
FKM99_RS07100	COG1349	DNA-binding transcription factor activity
FKM99_RS07105	COG0346	lactoylglutathione lyase activity
FKM99_RS07125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FKM99_RS07130	COG3537	Alpha-1,2-mannosidase
FKM99_RS07135	COG3537	Alpha-1,2-mannosidase
FKM99_RS07145	COG3537	Alpha-1,2-mannosidase
FKM99_RS07155	COG0737	Belongs to the 5'-nucleotidase family
FKM99_RS07165	COG1309	transcriptional regulator
FKM99_RS07185	COG1280	lysine exporter protein (LysE YggA)
FKM99_RS07200	COG0459	protein refolding
FKM99_RS07205	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FKM99_RS07215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FKM99_RS07245	COG1304	FMN binding
FKM99_RS07265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FKM99_RS07270	COG4786	Flagellar basal body rod
FKM99_RS07270	COG1256	bacterial-type flagellum assembly
FKM99_RS07280	COG1706	bacterial-type flagellum-dependent cell motility
FKM99_RS07285	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FKM99_RS07290	COG4786	Flagellar basal body rod
FKM99_RS07295	COG4787	bacterial-type flagellum-dependent cell motility
FKM99_RS07300	COG1749	Flagellar hook protein flgE
FKM99_RS07305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FKM99_RS07310	COG1558	bacterial-type flagellum-dependent cell motility
FKM99_RS07315	COG1815	bacterial-type flagellum-dependent cell motility
FKM99_RS07335	COG0741	lytic transglycosylase activity
FKM99_RS07340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FKM99_RS07360	COG1760	l-serine dehydratase
FKM99_RS07365	COG3104	oligopeptide transport
FKM99_RS07385	COG0583	DNA-binding transcription factor activity
FKM99_RS07400	COG2866	Carboxypeptidase
FKM99_RS07405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FKM99_RS07415	COG2990	Protein conserved in bacteria
FKM99_RS07440	COG3842	ATPase activity
FKM99_RS07450	COG1840	ABC-type Fe3 transport system, periplasmic component
FKM99_RS07455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FKM99_RS07460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FKM99_RS07465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FKM99_RS07470	COG1609	Transcriptional regulator
FKM99_RS07500	COG3240	lipase activity
FKM99_RS07510	COG1136	(ABC) transporter
FKM99_RS07510	COG0577	efflux transmembrane transporter activity
FKM99_RS07515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKM99_RS07520	COG2067	long-chain fatty acid transport protein
FKM99_RS07530	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FKM99_RS07545	COG1011	Hydrolase
FKM99_RS07585	COG0110	maltose O-acetyltransferase activity
FKM99_RS07590	COG1765	OsmC-like protein
FKM99_RS07600	COG1765	OsmC-like protein
FKM99_RS07605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FKM99_RS07605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FKM99_RS07620	COG3046	protein related to deoxyribodipyrimidine photolyase
FKM99_RS07630	COG3706	GGDEF domain
FKM99_RS07645	COG0840	transmembrane signaling receptor activity
FKM99_RS07650	COG3706	GGDEF domain
FKM99_RS07665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FKM99_RS07685	COG3033	Beta-eliminating lyase
FKM99_RS07695	COG0579	oxidoreductase
FKM99_RS07720	COG1114	Component of the transport system for branched-chain amino acids
FKM99_RS07725	COG2199	diguanylate cyclase activity
FKM99_RS07770	COG0583	DNA-binding transcription factor activity
FKM99_RS07780	COG0189	ligase activity
FKM99_RS07785	COG4067	protein conserved in archaea
FKM99_RS07785	COG0189	ligase activity
FKM99_RS07795	COG1166	arginine decarboxylase activity
FKM99_RS07800	COG0010	Belongs to the arginase family
FKM99_RS07805	COG2814	Major facilitator Superfamily
FKM99_RS07810	COG1770	oligopeptidase
FKM99_RS07825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FKM99_RS07830	COG1121	(ABC) transporter
FKM99_RS07835	COG0803	Belongs to the bacterial solute-binding protein 9 family
FKM99_RS07875	COG0848	biopolymer transport protein
FKM99_RS07880	COG0811	peptide transport
FKM99_RS07885	COG0811	peptide transport
FKM99_RS07905	COG0745	RESPONSE REGULATOR receiver
FKM99_RS07910	COG0039	L-malate dehydrogenase activity
FKM99_RS07915	COG0584	glycerophosphoryl diester phosphodiesterase
FKM99_RS07925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FKM99_RS07985	COG1901	pseudouridine methyltransferase
FKM99_RS07990	COG0312	modulator of DNA gyrase
FKM99_RS07995	COG0312	modulator of DNA gyrase
FKM99_RS08005	COG0351	phosphomethylpyrimidine kinase
FKM99_RS08010	COG1116	anion transmembrane transporter activity
FKM99_RS08015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FKM99_RS08020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FKM99_RS08025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FKM99_RS08030	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FKM99_RS08035	COG0352	thiamine-phosphate diphosphorylase activity
FKM99_RS08045	COG0243	molybdopterin cofactor binding
FKM99_RS08050	COG3005	denitrification pathway
FKM99_RS08060	COG1028	Short-chain dehydrogenase reductase Sdr
FKM99_RS08075	COG0454	-acetyltransferase
FKM99_RS08075	COG0456	acetyltransferase
FKM99_RS08095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FKM99_RS08100	COG1929	Belongs to the glycerate kinase type-1 family
FKM99_RS08105	COG2610	gluconate transmembrane transporter activity
FKM99_RS08110	COG3835	regulator
FKM99_RS08135	COG0546	phosphoglycolate phosphatase activity
FKM99_RS08150	COG0583	DNA-binding transcription factor activity
FKM99_RS08160	COG0583	DNA-binding transcription factor activity
FKM99_RS08170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FKM99_RS08175	COG3408	Glycogen debranching enzyme
FKM99_RS08175	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FKM99_RS08205	COG3047	cAMP biosynthetic process
FKM99_RS08210	COG1357	PFAM Pentapeptide repeats (8 copies)
FKM99_RS08240	COG2375	cellular response to nickel ion
FKM99_RS08245	COG0823	Involved in the tonB-independent uptake of proteins
FKM99_RS08250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FKM99_RS08270	COG0800	Aldolase
FKM99_RS08275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FKM99_RS08290	COG1917	Cupin 2, conserved barrel domain protein
FKM99_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
FKM99_RS08305	COG1414	Transcriptional regulator
FKM99_RS08320	COG0583	DNA-binding transcription factor activity
FKM99_RS08325	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FKM99_RS08330	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FKM99_RS08345	COG2199	diguanylate cyclase activity
FKM99_RS08355	COG0561	phosphatase activity
FKM99_RS08360	COG0583	DNA-binding transcription factor activity
FKM99_RS08375	COG0564	pseudouridine synthase activity
FKM99_RS08380	COG0534	Mate efflux family protein
FKM99_RS08390	COG5001	Diguanylate cyclase
FKM99_RS08400	COG3123	guanosine phosphorylase activity
FKM99_RS08440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FKM99_RS08450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FKM99_RS08455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FKM99_RS08470	COG2259	Doxx family
FKM99_RS08475	COG1741	Belongs to the pirin family
FKM99_RS08495	COG0363	glucosamine-6-phosphate deaminase activity
FKM99_RS08510	COG0786	glutamate:sodium symporter activity
FKM99_RS08515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FKM99_RS08520	COG1131	(ABC) transporter
FKM99_RS08530	COG0786	glutamate:sodium symporter activity
FKM99_RS08565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FKM99_RS08575	COG3279	Response regulator of the LytR AlgR family
FKM99_RS08580	COG3275	phosphorelay sensor kinase activity
FKM99_RS08600	COG1136	(ABC) transporter
FKM99_RS08615	COG0772	Belongs to the SEDS family
FKM99_RS08620	COG0217	transcriptional regulatory protein
FKM99_RS08645	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FKM99_RS08645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FKM99_RS08655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FKM99_RS08660	COG0592	DNA-directed DNA polymerase activity
FKM99_RS08665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FKM99_RS08670	COG0187	DNA topoisomerase II activity
FKM99_RS08690	COG0071	Belongs to the small heat shock protein (HSP20) family
FKM99_RS08695	COG3977	Valine--pyruvate aminotransferase
FKM99_RS08700	COG0366	Alpha amylase catalytic
FKM99_RS08705	COG0751	glycine-tRNA ligase activity
FKM99_RS08710	COG0752	glycyl-tRNA synthetase alpha subunit
FKM99_RS08715	COG2119	membrane
FKM99_RS08725	COG0425	Belongs to the sulfur carrier protein TusA family
FKM99_RS08740	COG0604	alcohol dehydrogenase
FKM99_RS08745	COG0183	Belongs to the thiolase family
FKM99_RS08750	COG1024	Enoyl-CoA hydratase
FKM99_RS08750	COG1250	3-hydroxyacyl-CoA dehydrogenase
FKM99_RS08755	COG1739	Uncharacterized protein family UPF0029
FKM99_RS08760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FKM99_RS08805	COG0583	DNA-binding transcription factor activity
FKM99_RS08810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FKM99_RS08815	COG2960	long-chain fatty acid transporting porin activity
FKM99_RS08825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKM99_RS08830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKM99_RS08885	COG4172	Belongs to the ABC transporter superfamily
FKM99_RS08890	COG0747	negative chemotaxis
FKM99_RS08895	COG0601	transmembrane transport
FKM99_RS08900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FKM99_RS08940	COG1609	Transcriptional regulator
FKM99_RS08945	COG0583	DNA-binding transcription factor activity
FKM99_RS08960	COG0129	dihydroxy-acid dehydratase activity
FKM99_RS08965	COG3265	gluconokinase activity
FKM99_RS08970	COG2610	gluconate transmembrane transporter activity
FKM99_RS08975	COG0800	Aldolase
FKM99_RS08980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FKM99_RS08985	COG0583	DNA-binding transcription factor activity
FKM99_RS08990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FKM99_RS08995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FKM99_RS09005	COG0339	signal peptide processing
FKM99_RS09010	COG1522	sequence-specific DNA binding
FKM99_RS09015	COG5001	Diguanylate cyclase
FKM99_RS09015	COG5002	protein histidine kinase activity
FKM99_RS09020	COG0742	ribosomal rna small subunit methyltransferase
FKM99_RS09035	COG0589	response to stress
FKM99_RS09040	COG1528	Iron-storage protein
FKM99_RS09050	COG2081	HI0933 family
FKM99_RS09085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FKM99_RS09090	COG0732	type I restriction modification DNA specificity domain
FKM99_RS09095	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FKM99_RS09110	COG2823	Periplasmic or secreted lipoprotein
FKM99_RS09160	COG0628	permease
FKM99_RS09175	COG1322	Protein conserved in bacteria
FKM99_RS09180	COG2226	methyltransferase
FKM99_RS09185	COG3165	ubiquinone biosynthetic process from chorismate
FKM99_RS09190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FKM99_RS09195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FKM99_RS09200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FKM99_RS09205	COG0805	protein transport
FKM99_RS09215	COG0084	hydrolase, TatD family'
FKM99_RS09240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FKM99_RS09240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FKM99_RS09250	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FKM99_RS09290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FKM99_RS09300	COG2204	response regulator
FKM99_RS09305	COG3852	Histidine kinase
FKM99_RS09315	COG0174	glutamine synthetase
FKM99_RS09320	COG1217	gtp-binding protein TYPA
FKM99_RS09335	COG1295	ribonuclease BN
FKM99_RS09340	COG1490	D-aminoacyl-tRNA deacylase activity
FKM99_RS09345	COG0456	acetyltransferase
FKM99_RS09355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FKM99_RS09360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FKM99_RS09365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FKM99_RS09370	COG3031	protein transport across the cell outer membrane
FKM99_RS09380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FKM99_RS09385	COG1459	type II secretion system
FKM99_RS09390	COG2165	general secretion pathway protein
FKM99_RS09395	COG2165	general secretion pathway protein
FKM99_RS09400	COG2165	general secretion pathway protein
FKM99_RS09405	COG4795	General secretion pathway protein
FKM99_RS09410	COG3156	type II secretion system protein K
FKM99_RS09415	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FKM99_RS09420	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FKM99_RS09430	COG1218	3'(2'),5'-bisphosphate nucleotidase
FKM99_RS09435	COG0494	nUDIX hydrolase
FKM99_RS09440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FKM99_RS09440	COG0316	Belongs to the HesB IscA family
FKM99_RS09445	COG1040	competence protein
FKM99_RS09450	COG0596	Alpha beta hydrolase
FKM99_RS09460	COG2183	response to ionizing radiation
FKM99_RS09470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FKM99_RS09490	COG2233	PERMEase
FKM99_RS09500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FKM99_RS09505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FKM99_RS09510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FKM99_RS09515	COG1758	RNA polymerase activity
FKM99_RS09520	COG0194	GDP metabolic process
FKM99_RS09535	COG0848	biopolymer transport protein
FKM99_RS09540	COG0811	peptide transport
FKM99_RS09565	COG4174	ABC transporter (Permease)
FKM99_RS09570	COG4239	(ABC) transporter, permease
FKM99_RS09575	COG0747	negative chemotaxis
FKM99_RS09580	COG0444	Belongs to the ABC transporter superfamily
FKM99_RS09585	COG4608	Belongs to the ABC transporter superfamily
FKM99_RS09595	COG1561	YicC-like family, N-terminal region
FKM99_RS09600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FKM99_RS09605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FKM99_RS09610	COG1560	Kdo2-lipid A biosynthetic process
FKM99_RS09615	COG1309	transcriptional regulator
FKM99_RS09620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FKM99_RS09635	COG2003	Belongs to the UPF0758 family
FKM99_RS09640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FKM99_RS09655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FKM99_RS09660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FKM99_RS09675	COG0463	Glycosyl transferase, family 2
FKM99_RS09680	COG0859	PFAM glycosyl transferase family 9
FKM99_RS09685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FKM99_RS09690	COG3642	lipopolysaccharide core region biosynthetic process
FKM99_RS09700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FKM99_RS09740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FKM99_RS09745	COG1519	Transferase
FKM99_RS09750	COG0859	PFAM glycosyl transferase family 9
FKM99_RS09760	COG1560	Kdo2-lipid A biosynthetic process
FKM99_RS09770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FKM99_RS09815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FKM99_RS09820	COG0438	transferase activity, transferring glycosyl groups
FKM99_RS09840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FKM99_RS09845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FKM99_RS09850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FKM99_RS09870	COG1215	transferase activity, transferring glycosyl groups
FKM99_RS09900	COG0438	transferase activity, transferring glycosyl groups
FKM99_RS09920	COG0149	triose-phosphate isomerase activity
FKM99_RS09945	COG1494	fructose-1,6-bisphosphatase
FKM99_RS09955	COG3074	FtsZ-dependent cytokinesis
FKM99_RS09960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FKM99_RS09965	COG1575	Belongs to the MenA family. Type 1 subfamily
FKM99_RS09970	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FKM99_RS09975	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FKM99_RS09985	COG1609	Transcriptional regulator
FKM99_RS09990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FKM99_RS10000	COG0254	rRNA binding
FKM99_RS10010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FKM99_RS10015	COG0088	Forms part of the polypeptide exit tunnel
FKM99_RS10025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FKM99_RS10030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FKM99_RS10035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FKM99_RS10040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FKM99_RS10050	COG0255	Belongs to the universal ribosomal protein uL29 family
FKM99_RS10055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FKM99_RS10060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FKM99_RS10065	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FKM99_RS10070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FKM99_RS10075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FKM99_RS10080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FKM99_RS10085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FKM99_RS10100	COG1841	ribosomal large subunit assembly
FKM99_RS10105	COG0200	Binds to the 23S rRNA
FKM99_RS10110	COG0201	protein transport
FKM99_RS10115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FKM99_RS10120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FKM99_RS10125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FKM99_RS10135	COG0202	RNA polymerase activity
FKM99_RS10140	COG0203	ribosomal protein L17
FKM99_RS10150	COG0545	Peptidyl-prolyl cis-trans isomerase
FKM99_RS10160	COG2153	protein acetylation
FKM99_RS10165	COG0513	Belongs to the DEAD box helicase family
FKM99_RS10175	COG0737	Belongs to the 5'-nucleotidase family
FKM99_RS10180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FKM99_RS10180	COG1648	precorrin-2 dehydrogenase activity
FKM99_RS10185	COG0175	sulfate reduction
FKM99_RS10190	COG2895	sulfate adenylyltransferase (ATP) activity
FKM99_RS10200	COG3273	potassium ion transport
FKM99_RS10200	COG0471	metal ion transport
FKM99_RS10205	COG0529	Catalyzes the synthesis of activated sulfate
FKM99_RS10225	COG4181	ATPase activity
FKM99_RS10240	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FKM99_RS10250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FKM99_RS10255	COG0729	surface antigen
FKM99_RS10260	COG2911	Protein conserved in bacteria
FKM99_RS10265	COG2105	PFAM AIG2 family protein
FKM99_RS10275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FKM99_RS10280	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FKM99_RS10290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FKM99_RS10295	COG0163	prenyltransferase activity
FKM99_RS10300	COG4143	(ABC) transporter
FKM99_RS10305	COG1178	ABC-type Fe3 transport system permease component
FKM99_RS10310	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FKM99_RS10330	COG2358	TRAP transporter, solute receptor (TAXI family
FKM99_RS10345	COG0039	L-malate dehydrogenase activity
FKM99_RS10355	COG0142	geranyltranstransferase activity
FKM99_RS10360	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FKM99_RS10370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FKM99_RS10375	COG2966	Psort location CytoplasmicMembrane, score
FKM99_RS10390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FKM99_RS10395	COG2967	ApaG domain
FKM99_RS10400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FKM99_RS10405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FKM99_RS10410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FKM99_RS10415	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FKM99_RS10420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FKM99_RS10430	COG0066	3-isopropylmalate dehydratase activity
FKM99_RS10435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FKM99_RS10440	COG0473	3-isopropylmalate dehydrogenase activity
FKM99_RS10445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FKM99_RS10470	COG0583	DNA-binding transcription factor activity
FKM99_RS10475	COG1022	Amp-dependent synthetase and ligase
FKM99_RS10480	COG0028	Belongs to the TPP enzyme family
FKM99_RS10485	COG0440	acetolactate synthase activity
FKM99_RS10500	COG0469	pyruvate kinase activity
FKM99_RS10510	COG1349	DNA-binding transcription factor activity
FKM99_RS10515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FKM99_RS10530	COG5002	protein histidine kinase activity
FKM99_RS10540	COG2376	Dihydroxyacetone kinase
FKM99_RS10545	COG1461	Dihydroxyacetone kinase
FKM99_RS10560	COG3722	fumarate hydratase activity
FKM99_RS10570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FKM99_RS10570	COG2213	PTS system mannitol-specific
FKM99_RS10605	COG1464	Belongs to the NlpA lipoprotein family
FKM99_RS10650	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FKM99_RS10675	COG0732	type I restriction modification DNA specificity domain
FKM99_RS10720	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FKM99_RS10730	COG3550	peptidyl-serine autophosphorylation
FKM99_RS10750	COG0358	DNA primase activity
FKM99_RS10755	COG1610	YqeY-like protein
FKM99_RS10760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FKM99_RS10765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FKM99_RS10770	COG0596	Alpha beta hydrolase
FKM99_RS10775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FKM99_RS10780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FKM99_RS10785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FKM99_RS10790	COG1968	undecaprenyl-diphosphatase activity
FKM99_RS10795	COG0617	tRNA 3'-terminal CCA addition
FKM99_RS10800	COG3267	Type II secretory pathway component ExeA
FKM99_RS10800	COG3409	Peptidoglycan-binding domain 1 protein
FKM99_RS10810	COG4991	sh3 domain protein
FKM99_RS10815	COG0306	phosphate transporter
FKM99_RS10820	COG1392	Phosphate transport regulator
FKM99_RS10825	COG3025	triphosphatase activity
FKM99_RS10840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FKM99_RS10845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FKM99_RS10845	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FKM99_RS10850	COG1538	Outer membrane efflux protein
FKM99_RS10855	COG0494	nUDIX hydrolase
FKM99_RS10860	COG3151	Protein conserved in bacteria
FKM99_RS10870	COG3150	esterase
FKM99_RS10880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FKM99_RS10885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FKM99_RS10895	COG3105	Protein conserved in bacteria
FKM99_RS10905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FKM99_RS10915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FKM99_RS10920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FKM99_RS10925	COG0723	plastoquinol--plastocyanin reductase activity
FKM99_RS10930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FKM99_RS10935	COG2857	Cytochrome c1
FKM99_RS10940	COG0625	glutathione transferase activity
FKM99_RS10945	COG2969	positive regulation of protein catabolic process
FKM99_RS10950	COG2823	Periplasmic or secreted lipoprotein
FKM99_RS10955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FKM99_RS10960	COG0792	nuclease activity
FKM99_RS10970	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FKM99_RS10985	COG0275	rRNA processing
FKM99_RS10990	COG3116	cell division
FKM99_RS10995	COG0768	penicillin binding
FKM99_RS11000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FKM99_RS11005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FKM99_RS11010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FKM99_RS11015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FKM99_RS11020	COG0772	Belongs to the SEDS family
FKM99_RS11025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FKM99_RS11030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FKM99_RS11035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FKM99_RS11040	COG0849	cell division
FKM99_RS11045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FKM99_RS11050	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FKM99_RS11060	COG0653	protein targeting
FKM99_RS11065	COG0494	nUDIX hydrolase
FKM99_RS11070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FKM99_RS11075	COG0505	Belongs to the CarA family
FKM99_RS11080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FKM99_RS11095	COG0730	response to heat
FKM99_RS11110	COG0583	DNA-binding transcription factor activity
FKM99_RS11115	COG2860	membrane
FKM99_RS11120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FKM99_RS11130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FKM99_RS11140	COG0493	'glutamate synthase
FKM99_RS11145	COG0070	glutamate synthase
FKM99_RS11145	COG0069	glutamate synthase activity
FKM99_RS11145	COG0067	glutamate synthase
FKM99_RS11155	COG0070	glutamate synthase
FKM99_RS11155	COG0067	glutamate synthase
FKM99_RS11155	COG0069	glutamate synthase activity
FKM99_RS11160	COG1242	4 iron, 4 sulfur cluster binding
FKM99_RS11165	COG2203	Gaf domain
FKM99_RS11165	COG5001	Diguanylate cyclase
FKM99_RS11165	COG4251	negative regulation of phosphorylation
FKM99_RS11165	COG3706	GGDEF domain
FKM99_RS11170	COG5002	protein histidine kinase activity
FKM99_RS11170	COG2198	Histidine kinase
FKM99_RS11170	COG0784	Response regulator, receiver
FKM99_RS11180	COG0745	RESPONSE REGULATOR receiver
FKM99_RS11195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FKM99_RS11210	COG0083	homoserine kinase activity
FKM99_RS11215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FKM99_RS11220	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FKM99_RS11225	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FKM99_RS11235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FKM99_RS11250	COG1115	amino acid carrier protein
FKM99_RS11255	COG3022	response to hydroperoxide
FKM99_RS11260	COG0513	Belongs to the DEAD box helicase family
FKM99_RS11265	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FKM99_RS11275	COG0716	FMN binding
FKM99_RS11280	COG4974	Belongs to the 'phage' integrase family
FKM99_RS11285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FKM99_RS11290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FKM99_RS11300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FKM99_RS11315	COG0667	Aldo Keto reductase
FKM99_RS11325	COG3066	DNA modification
FKM99_RS11335	COG0494	nUDIX hydrolase
FKM99_RS11345	COG0730	response to heat
FKM99_RS11350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FKM99_RS11355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FKM99_RS11365	COG1283	sodium-dependent phosphate transmembrane transporter activity
FKM99_RS11370	COG0583	DNA-binding transcription factor activity
FKM99_RS11380	COG0640	Transcriptional regulator
FKM99_RS11390	COG0268	Binds directly to 16S ribosomal RNA
FKM99_RS11395	COG0728	peptidoglycan biosynthetic process
FKM99_RS11400	COG0196	riboflavin kinase activity
FKM99_RS11405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FKM99_RS11410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FKM99_RS11415	COG1047	Peptidyl-prolyl cis-trans
FKM99_RS11420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FKM99_RS11425	COG3279	Response regulator of the LytR AlgR family
FKM99_RS11430	COG3275	phosphorelay sensor kinase activity
FKM99_RS11435	COG1966	Carbon starvation protein
FKM99_RS11450	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FKM99_RS11455	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FKM99_RS11460	COG1472	Belongs to the glycosyl hydrolase 3 family
FKM99_RS11465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FKM99_RS11470	COG0287	Prephenate dehydrogenase
FKM99_RS11470	COG1605	Chorismate mutase
FKM99_RS11475	COG0739	heme binding
FKM99_RS11490	COG0488	(ABC) transporter
FKM99_RS11500	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FKM99_RS11505	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FKM99_RS11510	COG1605	Chorismate mutase
FKM99_RS11510	COG0077	Prephenate dehydratase
FKM99_RS11515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FKM99_RS11520	COG0741	lytic transglycosylase activity
FKM99_RS11525	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FKM99_RS11530	COG0564	pseudouridine synthase activity
FKM99_RS11540	COG0542	response to heat
FKM99_RS11600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FKM99_RS11605	COG0826	peptidase U32
FKM99_RS11610	COG2974	May be involved in recombination
FKM99_RS11620	COG0745	RESPONSE REGULATOR receiver
FKM99_RS11625	COG5002	protein histidine kinase activity
FKM99_RS11635	COG0248	Ppx GppA phosphatase
FKM99_RS11640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FKM99_RS11650	COG0581	inorganic phosphate transmembrane transporter activity
FKM99_RS11655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FKM99_RS11660	COG0704	Plays a role in the regulation of phosphate uptake
FKM99_RS11670	COG3142	Participates in the control of copper homeostasis
FKM99_RS11680	COG0450	alkyl hydroperoxide reductase
FKM99_RS11685	COG0583	DNA-binding transcription factor activity
FKM99_RS11695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FKM99_RS11705	COG0517	IMP dehydrogenase activity
FKM99_RS11720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FKM99_RS11725	COG0343	queuine tRNA-ribosyltransferase activity
FKM99_RS11730	COG1862	Preprotein translocase
FKM99_RS11735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FKM99_RS11740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FKM99_RS11750	COG0483	inositol monophosphate 1-phosphatase activity
FKM99_RS11765	COG1104	cysteine desulfurase activity
FKM99_RS11770	COG0822	iron-sulfur transferase activity
FKM99_RS11780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FKM99_RS11785	COG0443	Heat shock 70 kDa protein
FKM99_RS11790	COG0633	Ferredoxin
FKM99_RS11795	COG2975	iron-sulfur cluster assembly
FKM99_RS11800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FKM99_RS11805	COG0105	UTP biosynthetic process
FKM99_RS11810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FKM99_RS11825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FKM99_RS11830	COG0124	histidyl-tRNA synthetase
FKM99_RS11835	COG2976	Protein conserved in bacteria
FKM99_RS11840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FKM99_RS11845	COG1160	GTP binding
FKM99_RS11860	COG1570	exodeoxyribonuclease VII activity
FKM99_RS11865	COG0516	GMP reductase activity
FKM99_RS11865	COG0517	IMP dehydrogenase activity
FKM99_RS11870	COG0519	Catalyzes the synthesis of GMP from XMP
FKM99_RS11870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FKM99_RS11875	COG1757	Na H antiporter
FKM99_RS11885	COG1584	GPR1 FUN34 yaaH family protein
FKM99_RS11895	COG1115	amino acid carrier protein
FKM99_RS11935	COG2873	o-acetylhomoserine
FKM99_RS11940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FKM99_RS11945	COG3246	L-lysine catabolic process to acetate
FKM99_RS11960	COG3153	acetyltransferase
FKM99_RS11960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FKM99_RS11965	COG0583	DNA-binding transcription factor activity
FKM99_RS12010	COG3706	GGDEF domain
FKM99_RS12040	COG0732	type I restriction modification DNA specificity domain
FKM99_RS12100	COG0582	viral genome integration into host DNA
FKM99_RS12110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FKM99_RS12115	COG2867	negative regulation of translational initiation
FKM99_RS12120	COG2914	Belongs to the UPF0125 (RnfH) family
FKM99_RS12125	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FKM99_RS12130	COG0497	DNA recombination
FKM99_RS12140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FKM99_RS12145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FKM99_RS12155	COG0443	Heat shock 70 kDa protein
FKM99_RS12160	COG0484	heat shock protein binding
FKM99_RS12200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FKM99_RS12215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FKM99_RS12220	COG0047	phosphoribosylformylglycinamidine synthase activity
FKM99_RS12220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FKM99_RS12245	COG2195	Cleaves the N-terminal amino acid of tripeptides
FKM99_RS12250	COG2252	PERMEase
FKM99_RS12255	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FKM99_RS12260	COG1073	alpha beta
FKM99_RS12270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FKM99_RS12275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FKM99_RS12280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FKM99_RS12285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FKM99_RS12285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FKM99_RS12305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FKM99_RS12310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FKM99_RS12315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FKM99_RS12320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FKM99_RS12325	COG0142	geranyltranstransferase activity
FKM99_RS12330	COG1722	exodeoxyribonuclease VII activity
FKM99_RS12335	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FKM99_RS12340	COG2885	chlorophyll binding
FKM99_RS12345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FKM99_RS12345	COG0301	tRNA thio-modification
FKM99_RS12350	COG0583	DNA-binding transcription factor activity
FKM99_RS12360	COG2363	Small membrane protein
FKM99_RS12365	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FKM99_RS12375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FKM99_RS12380	COG1611	Belongs to the LOG family
FKM99_RS12395	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FKM99_RS12395	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FKM99_RS12405	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FKM99_RS12410	COG1464	Belongs to the NlpA lipoprotein family
FKM99_RS12415	COG2011	ABC-type metal ion transport system permease component
FKM99_RS12420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FKM99_RS12430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FKM99_RS12440	COG1263	PTS System
FKM99_RS12440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FKM99_RS12445	COG0366	Alpha amylase catalytic
FKM99_RS12460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FKM99_RS12465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FKM99_RS12470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FKM99_RS12475	COG0321	lipoyl(octanoyl) transferase activity
FKM99_RS12480	COG2921	Belongs to the UPF0250 family
FKM99_RS12485	COG1686	Belongs to the peptidase S11 family
FKM99_RS12490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FKM99_RS12495	COG0772	Belongs to the SEDS family
FKM99_RS12500	COG0768	penicillin binding
FKM99_RS12505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FKM99_RS12510	COG0799	negative regulation of ribosome biogenesis
FKM99_RS12515	COG1466	dna polymerase III delta subunit
FKM99_RS12520	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FKM99_RS12525	COG0495	leucyl-tRNA aminoacylation
FKM99_RS12530	COG2888	peptidyl-tyrosine sulfation
FKM99_RS12535	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FKM99_RS12540	COG4535	Mg2 and Co2 transporter CorC
FKM99_RS12545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FKM99_RS12550	COG1702	phosphate starvation-inducible protein PhoH
FKM99_RS12555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FKM99_RS12565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FKM99_RS12665	COG0012	GTP binding
FKM99_RS12670	COG0193	aminoacyl-tRNA hydrolase activity
FKM99_RS12675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FKM99_RS12680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FKM99_RS12685	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FKM99_RS12690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FKM99_RS12695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FKM99_RS12700	COG2890	protein-(glutamine-N5) methyltransferase activity
FKM99_RS12705	COG3094	Invasion gene expression up-regulator, SirB
FKM99_RS12710	COG2912	Transglutaminase-like superfamily
FKM99_RS12715	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FKM99_RS12720	COG0737	Belongs to the 5'-nucleotidase family
FKM99_RS12730	COG1187	pseudouridine synthase activity
FKM99_RS12735	COG2840	Smr protein MutS2
FKM99_RS12775	COG2217	Heavy metal translocating P-type atpase
FKM99_RS12775	COG2608	mercury ion transmembrane transporter activity
FKM99_RS12790	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FKM99_RS12795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FKM99_RS12855	COG0835	chemotaxis
FKM99_RS12855	COG0784	Response regulator, receiver
FKM99_RS12860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FKM99_RS12865	COG1815	bacterial-type flagellum-dependent cell motility
FKM99_RS12870	COG1558	bacterial-type flagellum-dependent cell motility
FKM99_RS12880	COG1749	Flagellar hook protein flgE
FKM99_RS12890	COG4787	bacterial-type flagellum-dependent cell motility
FKM99_RS12900	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FKM99_RS12905	COG1706	bacterial-type flagellum-dependent cell motility
FKM99_RS12910	COG1705	Flagellar rod assembly protein muramidase FlgJ
FKM99_RS12910	COG3951	Flagellar rod assembly protein muramidase FlgJ
FKM99_RS12920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FKM99_RS12930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FKM99_RS12940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FKM99_RS12945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FKM99_RS12955	COG2190	(PTS) system
FKM99_RS12960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FKM99_RS12965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FKM99_RS12975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FKM99_RS12980	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FKM99_RS12985	COG3115	cell septum assembly
FKM99_RS12990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FKM99_RS13015	COG0330	HflC and HflK could
FKM99_RS13020	COG2194	sulfuric ester hydrolase activity
FKM99_RS13040	COG1215	transferase activity, transferring glycosyl groups
FKM99_RS13045	COG1215	transferase activity, transferring glycosyl groups
FKM99_RS13050	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FKM99_RS13055	COG3118	belongs to the thioredoxin family
FKM99_RS13055	COG0457	Tetratricopeptide repeat
FKM99_RS13060	COG3118	belongs to the thioredoxin family
FKM99_RS13070	COG0300	oxidoreductase activity
FKM99_RS13075	COG1090	epimerase
FKM99_RS13105	COG0622	Phosphoesterase
FKM99_RS13125	COG3710	Transcriptional regulator
FKM99_RS13130	COG0326	Molecular chaperone. Has ATPase activity
FKM99_RS13135	COG0563	adenylate kinase activity
FKM99_RS13140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FKM99_RS13145	COG3104	oligopeptide transport
FKM99_RS13150	COG0250	Participates in transcription elongation, termination and antitermination
FKM99_RS13155	COG0367	asparagine synthase
FKM99_RS13160	COG4651	solute:proton antiporter activity
FKM99_RS13160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FKM99_RS13165	COG1846	Transcriptional regulator
FKM99_RS13165	COG1940	carbohydrate kinase activity
FKM99_RS13170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FKM99_RS13180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FKM99_RS13180	COG1263	PTS System
FKM99_RS13185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FKM99_RS13190	COG0735	belongs to the Fur family
FKM99_RS13210	COG0596	Alpha beta hydrolase
FKM99_RS13215	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FKM99_RS13220	COG0033	Phosphoglucomutase
FKM99_RS13230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FKM99_RS13245	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FKM99_RS13250	COG1053	succinate dehydrogenase
FKM99_RS13255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FKM99_RS13260	COG0567	Dehydrogenase, E1 component
FKM99_RS13265	COG0508	dehydrogenase complex catalyzes the overall conversion of
FKM99_RS13270	COG0045	succinate-CoA ligase (ADP-forming) activity
FKM99_RS13280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FKM99_RS13285	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FKM99_RS13290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FKM99_RS13295	COG2233	PERMEase
FKM99_RS13315	COG4783	chaperone-mediated protein folding
FKM99_RS13330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FKM99_RS13335	COG2716	regulation of RNA biosynthetic process
FKM99_RS13340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FKM99_RS13345	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FKM99_RS13360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FKM99_RS13365	COG1393	Belongs to the ArsC family
FKM99_RS13395	COG2837	iron assimilation
FKM99_RS13400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FKM99_RS13410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FKM99_RS13415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FKM99_RS13420	COG1334	flagellar protein FlaG
FKM99_RS13425	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FKM99_RS13435	COG1516	flagellar protein fliS
FKM99_RS13455	COG1677	Flagellar hook-basal body complex protein FliE
FKM99_RS13465	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FKM99_RS13515	COG1987	bacterial-type flagellum assembly
FKM99_RS13520	COG1684	flagellar biosynthetic protein fliR
FKM99_RS13555	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FKM99_RS13560	COG2198	Histidine kinase
FKM99_RS13560	COG0784	Response regulator, receiver
FKM99_RS13560	COG0643	Histidine kinase
FKM99_RS13565	COG2201	protein-glutamate methylesterase activity
FKM99_RS13570	COG1192	Involved in chromosome partitioning
FKM99_RS13580	COG0835	chemotaxis
FKM99_RS13590	COG4133	protoheme IX ABC transporter activity
FKM99_RS13595	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FKM99_RS13600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FKM99_RS13605	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FKM99_RS13610	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FKM99_RS13615	COG1138	Cytochrome C-type biogenesis protein
FKM99_RS13620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FKM99_RS13635	COG2853	Lipoprotein
FKM99_RS13645	COG2067	long-chain fatty acid transport protein
FKM99_RS13665	COG0183	Belongs to the thiolase family
FKM99_RS13670	COG1024	Enoyl-CoA hydratase
FKM99_RS13670	COG1250	3-hydroxyacyl-CoA dehydrogenase
FKM99_RS13685	COG2062	phosphohistidine phosphatase, SixA
FKM99_RS13690	COG2840	Smr protein MutS2
FKM99_RS13695	COG2890	protein-(glutamine-N5) methyltransferase activity
FKM99_RS13700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FKM99_RS13705	COG2860	membrane
FKM99_RS13715	COG3101	peptidyl-lysine hydroxylation
FKM99_RS13730	COG0431	NADPH-dependent FMN reductase
FKM99_RS13795	COG4387	Mu-like prophage protein GP36
FKM99_RS13805	COG4397	Mu-like prophage major head subunit gpT
FKM99_RS13815	COG4388	Caudovirus prohead serine protease
FKM99_RS13845	COG4383	Mu-like prophage protein gp29
FKM99_RS13850	COG4373	Mu-like prophage FluMu protein gp28
FKM99_RS13860	COG0640	Transcriptional regulator
FKM99_RS13885	COG5566	PFAM Mor transcription activator
FKM99_RS13915	COG4382	Mu-like prophage protein Gp16
FKM99_RS13960	COG2842	Transposition protein
FKM99_RS13965	COG2801	Transposase and inactivated derivatives
FKM99_RS13975	COG3423	Transcriptional regulator
FKM99_RS13980	COG2932	Transcriptional regulator
FKM99_RS13990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FKM99_RS14000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FKM99_RS14005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FKM99_RS14015	COG0101	tRNA pseudouridine synthase activity
FKM99_RS14020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FKM99_RS14025	COG0285	dihydrofolate synthase activity
FKM99_RS14030	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FKM99_RS14035	COG1286	toxin biosynthetic process
FKM99_RS14040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FKM99_RS14045	COG0583	DNA-binding transcription factor activity
FKM99_RS14050	COG0745	RESPONSE REGULATOR receiver
FKM99_RS14060	COG2832	Protein of unknown function (DUF454)
FKM99_RS14065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FKM99_RS14075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FKM99_RS14080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FKM99_RS14085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FKM99_RS14090	COG0814	amino acid
FKM99_RS14095	COG0251	oxidation-reduction process
FKM99_RS14100	COG3681	Belongs to the UPF0597 family
FKM99_RS14115	COG2261	transglycosylase associated protein
FKM99_RS14120	COG2983	Belongs to the UPF0260 family
FKM99_RS14125	COG0668	transmembrane transport
FKM99_RS14130	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FKM99_RS14135	COG0346	lactoylglutathione lyase activity
FKM99_RS14145	COG1785	Belongs to the alkaline phosphatase family
FKM99_RS14165	COG2226	methyltransferase
FKM99_RS14180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FKM99_RS14185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FKM99_RS14195	COG3139	Protein of unknown function (DUF1315)
FKM99_RS14200	COG0252	asparaginase activity
FKM99_RS14205	COG0616	signal peptide processing
FKM99_RS14210	COG1902	pentaerythritol trinitrate reductase activity
FKM99_RS14210	COG0446	pyridine nucleotide-disulphide oxidoreductase
FKM99_RS14215	COG0778	Nitroreductase
FKM99_RS14220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FKM99_RS14240	COG0123	including yeast histone deacetylase and acetoin utilization protein
FKM99_RS14260	COG0582	viral genome integration into host DNA
FKM99_RS14280	COG3083	sulfuric ester hydrolase activity
FKM99_RS14285	COG3082	Protein of unknown function (DUF1414)
FKM99_RS14290	COG3081	Nucleoid-associated protein
FKM99_RS14305	COG1757	Na H antiporter
FKM99_RS14310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FKM99_RS14315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FKM99_RS14320	COG2095	MarC family integral membrane protein
FKM99_RS14325	COG1454	alcohol dehydrogenase
FKM99_RS14325	COG1012	belongs to the aldehyde dehydrogenase family
FKM99_RS14345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FKM99_RS14355	COG2056	Na+-H+ antiporter family
FKM99_RS14360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FKM99_RS14375	COG2885	chlorophyll binding
FKM99_RS14385	COG0346	lactoylglutathione lyase activity
FKM99_RS14390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FKM99_RS14395	COG4660	Part of a membrane complex involved in electron transport
FKM99_RS14400	COG4659	FMN binding
FKM99_RS14405	COG4658	electron transport chain
FKM99_RS14410	COG4656	Part of a membrane complex involved in electron transport
FKM99_RS14415	COG2878	Part of a membrane complex involved in electron transport
FKM99_RS14420	COG4657	Part of a membrane complex involved in electron transport
FKM99_RS14435	COG0556	nucleotide-excision repair
FKM99_RS14440	COG2204	response regulator
FKM99_RS14445	COG2198	Histidine kinase
FKM99_RS14450	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FKM99_RS14455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FKM99_RS14460	COG0521	Mo-molybdopterin cofactor biosynthetic process
FKM99_RS14465	COG0315	cyclic pyranopterin monophosphate synthase activity
FKM99_RS14470	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FKM99_RS14475	COG0314	molybdopterin synthase activity
FKM99_RS14485	COG0601	transmembrane transport
FKM99_RS14490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FKM99_RS14495	COG0444	Belongs to the ABC transporter superfamily
FKM99_RS14505	COG0435	Glutathione S-transferase
FKM99_RS14515	COG3174	membrane
FKM99_RS14520	COG0280	phosphate acetyltransferase
FKM99_RS14520	COG0857	belongs to the CobB CobQ family
FKM99_RS14525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FKM99_RS14530	COG3092	negative regulation of chromosome organization
FKM99_RS14540	COG4120	Belongs to the binding-protein-dependent transport system permease family
FKM99_RS14545	COG1122	ATPase activity
FKM99_RS14550	COG0366	Alpha amylase catalytic
FKM99_RS14555	COG2199	diguanylate cyclase activity
FKM99_RS14555	COG2203	Gaf domain
FKM99_RS14560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FKM99_RS14565	COG3012	SEC-C Motif Domain Protein
FKM99_RS14565	COG3318	Belongs to the UPF0149 family
FKM99_RS14570	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FKM99_RS14575	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FKM99_RS14580	COG2186	Transcriptional regulator
FKM99_RS14590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FKM99_RS14590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FKM99_RS14595	COG0489	protein tyrosine kinase activity
FKM99_RS14600	COG0572	uridine kinase
FKM99_RS14610	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FKM99_RS14615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FKM99_RS14620	COG0659	secondary active sulfate transmembrane transporter activity
FKM99_RS14630	COG1530	ribonuclease E activity
FKM99_RS14645	COG0564	pseudouridine synthase activity
FKM99_RS14650	COG0424	maF-like protein
FKM99_RS14655	COG1399	metal-binding, possibly nucleic acid-binding protein
FKM99_RS14665	COG0416	fatty acid biosynthetic process
FKM99_RS14670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FKM99_RS14700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FKM99_RS14705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FKM99_RS14715	COG0084	hydrolase, TatD family'
FKM99_RS14720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FKM99_RS14720	COG1263	PTS System
FKM99_RS14740	COG0733	neurotransmitter:sodium symporter activity
FKM99_RS14755	COG4667	esterase of the alpha-beta hydrolase superfamily
FKM99_RS14760	COG0469	pyruvate kinase activity
FKM99_RS14765	COG1940	carbohydrate kinase activity
FKM99_RS14770	COG0835	chemotaxis
FKM99_RS14770	COG0784	Response regulator, receiver
FKM99_RS14775	COG0587	DNA-directed DNA polymerase activity
FKM99_RS14790	COG1028	Short-chain dehydrogenase reductase Sdr
FKM99_RS14795	COG0616	signal peptide processing
FKM99_RS14800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FKM99_RS14805	COG0539	negative regulation of cytoplasmic translation
FKM99_RS14815	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FKM99_RS14820	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FKM99_RS14825	COG0284	orotidine-5'-phosphate decarboxylase activity
FKM99_RS14830	COG4166	transmembrane transport
FKM99_RS14855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FKM99_RS14865	COG3008	intermembrane lipid transfer
FKM99_RS14865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FKM99_RS14870	COG2995	paraquat-inducible protein a
FKM99_RS14880	COG2863	cytochrome
FKM99_RS14920	COG4232	protein-disulfide reductase activity
FKM99_RS14925	COG3118	belongs to the thioredoxin family
FKM99_RS14955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKM99_RS14965	COG0577	efflux transmembrane transporter activity
FKM99_RS14965	COG1136	(ABC) transporter
FKM99_RS14970	COG0577	efflux transmembrane transporter activity
FKM99_RS14970	COG1136	(ABC) transporter
FKM99_RS14975	COG0577	efflux transmembrane transporter activity
FKM99_RS14975	COG1136	(ABC) transporter
FKM99_RS14980	COG1335	isochorismatase
FKM99_RS15030	COG5002	protein histidine kinase activity
FKM99_RS15030	COG3850	Histidine kinase
FKM99_RS15035	COG0745	RESPONSE REGULATOR receiver
FKM99_RS15045	COG0840	transmembrane signaling receptor activity
FKM99_RS15050	COG1032	radical SAM domain protein
FKM99_RS15055	COG2203	Gaf domain
FKM99_RS15055	COG3706	GGDEF domain
FKM99_RS15055	COG4251	negative regulation of phosphorylation
FKM99_RS15055	COG5001	Diguanylate cyclase
FKM99_RS15070	COG0583	DNA-binding transcription factor activity
FKM99_RS15080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FKM99_RS15090	COG2350	Protein conserved in bacteria
FKM99_RS15100	COG2917	probably involved in intracellular septation
FKM99_RS15120	COG1301	dicarboxylic acid transport
FKM99_RS15130	COG0318	PFAM AMP-dependent synthetase and ligase
FKM99_RS15135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FKM99_RS15145	COG0159	tryptophan synthase activity
FKM99_RS15150	COG0133	tryptophan synthase activity
FKM99_RS15155	COG0134	indole-3-glycerol-phosphate synthase activity
FKM99_RS15155	COG0135	phosphoribosylanthranilate isomerase activity
FKM99_RS15160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FKM99_RS15165	COG0512	Glutamine amidotransferase of anthranilate synthase
FKM99_RS15170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FKM99_RS15180	COG0613	PHP domain protein
FKM99_RS15185	COG0009	L-threonylcarbamoyladenylate synthase
FKM99_RS15195	COG1187	pseudouridine synthase activity
FKM99_RS15205	COG3099	Belongs to the UPF0263 family
FKM99_RS15210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FKM99_RS15220	COG0417	DNA replication proofreading
FKM99_RS15225	COG2197	response regulator
FKM99_RS15230	COG0322	excinuclease ABC activity
FKM99_RS15270	COG0019	diaminopimelate decarboxylase activity
FKM99_RS15295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FKM99_RS15300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FKM99_RS15305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FKM99_RS15325	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FKM99_RS15335	COG0437	4 iron, 4 sulfur cluster binding
FKM99_RS15340	COG3301	Polysulphide reductase, NrfD
FKM99_RS15345	COG1138	Cytochrome C-type biogenesis protein
FKM99_RS15355	COG4235	cytochrome complex assembly
FKM99_RS15355	COG3088	subunit of a heme lyase
FKM99_RS15365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FKM99_RS15390	COG2989	Protein conserved in bacteria
FKM99_RS15395	COG3108	Peptidase M15
FKM99_RS15400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FKM99_RS15415	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FKM99_RS15440	COG1846	Transcriptional regulator
FKM99_RS15445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FKM99_RS15450	COG0840	transmembrane signaling receptor activity
FKM99_RS15470	COG1448	Aminotransferase
FKM99_RS15495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FKM99_RS15505	COG0017	Asparaginyl-tRNA synthetase
FKM99_RS15510	COG0840	transmembrane signaling receptor activity
FKM99_RS15515	COG0720	synthase
FKM99_RS15525	COG2200	EAL domain
FKM99_RS15530	COG1760	l-serine dehydratase
FKM99_RS15535	COG0814	amino acid
FKM99_RS15540	COG0494	nUDIX hydrolase
FKM99_RS15550	COG0784	Response regulator, receiver
FKM99_RS15550	COG2205	protein histidine kinase activity
FKM99_RS15555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FKM99_RS15575	COG3106	COG3106 Predicted ATPase
FKM99_RS15580	COG3768	UPF0283 membrane protein
FKM99_RS15590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FKM99_RS15975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FKM99_RS16015	COG1484	DNA-dependent DNA replication
FKM99_RS16020	COG4584	PFAM Integrase catalytic
FKM99_RS16155	COG1335	isochorismatase
FKM99_RS16245	COG2026	Addiction module toxin, RelE StbE family
FKM99_RS16305	COG2161	toxin-antitoxin pair type II binding
FKM99_RS16310	COG4115	mRNA cleavage
FKM99_RS16445	COG4584	PFAM Integrase catalytic
FKM99_RS16450	COG1484	DNA-dependent DNA replication
FKM99_RS16645	COG2161	toxin-antitoxin pair type II binding
FKM99_RS16650	COG4115	mRNA cleavage
FKM99_RS16845	COG0346	lactoylglutathione lyase activity
FKM99_RS16915	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FKM99_RS16920	COG0583	DNA-binding transcription factor activity
FKM99_RS16955	COG0471	metal ion transport
FKM99_RS16960	COG4191	Histidine kinase
FKM99_RS16960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FKM99_RS16970	COG5001	Diguanylate cyclase
FKM99_RS16970	COG3300	MHYT domain
FKM99_RS16980	COG1280	lysine exporter protein (LysE YggA)
FKM99_RS16985	COG1328	CTP reductase activity
FKM99_RS16990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FKM99_RS17000	COG0861	Integral membrane protein TerC family
FKM99_RS17010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FKM99_RS17025	COG0814	amino acid
FKM99_RS17050	COG1132	(ABC) transporter
FKM99_RS17055	COG1132	(ABC) transporter
FKM99_RS17085	COG0443	Heat shock 70 kDa protein
FKM99_RS17090	COG0443	Heat shock 70 kDa protein
FKM99_RS17130	COG0243	molybdopterin cofactor binding
FKM99_RS17135	COG0437	4 iron, 4 sulfur cluster binding
FKM99_RS17140	COG3302	dmso reductase anchor subunit
FKM99_RS17155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FKM99_RS17160	COG1643	Atp-dependent helicase
FKM99_RS17175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FKM99_RS17185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FKM99_RS17190	COG1215	transferase activity, transferring glycosyl groups
FKM99_RS17195	COG0438	transferase activity, transferring glycosyl groups
FKM99_RS17240	COG2204	response regulator
FKM99_RS17275	COG1793	dna ligase
FKM99_RS17285	COG0534	Mate efflux family protein
FKM99_RS17290	COG0307	riboflavin synthase, alpha
FKM99_RS17300	COG3001	Fructosamine kinase
FKM99_RS17305	COG2201	protein-glutamate methylesterase activity
FKM99_RS17310	COG3706	GGDEF domain
FKM99_RS17320	COG0791	NLP P60 protein
FKM99_RS17325	COG3290	protein histidine kinase activity
FKM99_RS17325	COG0840	transmembrane signaling receptor activity
FKM99_RS17360	COG3148	PFAM DTW domain containing protein
FKM99_RS17365	COG1940	carbohydrate kinase activity
FKM99_RS17380	COG0746	molybdenum cofactor guanylyltransferase activity
FKM99_RS17385	COG3842	ATPase activity
FKM99_RS17405	COG2204	response regulator
FKM99_RS17410	COG4191	Histidine kinase
FKM99_RS17420	COG0488	(ABC) transporter
FKM99_RS17425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FKM99_RS17450	COG3381	protein complex oligomerization
FKM99_RS17460	COG3383	formate dehydrogenase (NAD+) activity
FKM99_RS17460	COG0243	molybdopterin cofactor binding
FKM99_RS17465	COG0437	4 iron, 4 sulfur cluster binding
FKM99_RS17505	COG0004	ammonium transporteR
FKM99_RS17515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FKM99_RS17520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FKM99_RS17530	COG1177	transmembrane transport
FKM99_RS17540	COG3842	ATPase activity
FKM99_RS17560	COG0037	tRNA processing
FKM99_RS17570	COG0589	response to stress
FKM99_RS17575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FKM99_RS17590	COG2217	Heavy metal translocating P-type atpase
FKM99_RS17600	COG2010	Cytochrome c
FKM99_RS17615	COG3278	Belongs to the heme-copper respiratory oxidase family
FKM99_RS17630	COG0784	Response regulator, receiver
FKM99_RS17630	COG2205	protein histidine kinase activity
FKM99_RS17650	COG3120	sequence-specific DNA binding
FKM99_RS17655	COG1067	ATP-dependent peptidase activity
FKM99_RS17660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FKM99_RS17675	COG0488	(ABC) transporter
FKM99_RS17685	COG0116	Belongs to the methyltransferase superfamily
FKM99_RS17685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FKM99_RS17700	COG0167	dihydroorotate dehydrogenase activity
FKM99_RS17705	COG2902	Dehydrogenase
FKM99_RS17715	COG0308	aminopeptidase N
FKM99_RS17730	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FKM99_RS17735	COG1956	GAF domain-containing protein
FKM99_RS17740	COG1132	(ABC) transporter
FKM99_RS17745	COG2995	paraquat-inducible protein a
FKM99_RS17750	COG3008	intermembrane lipid transfer
FKM99_RS17760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FKM99_RS17760	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FKM99_RS17780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FKM99_RS17785	COG1666	GTP binding
FKM99_RS17805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FKM99_RS17810	COG4597	amino acid ABC transporter
FKM99_RS17815	COG0765	amino acid transport
FKM99_RS17820	COG1126	abc transporter atp-binding protein
FKM99_RS17825	COG0670	Belongs to the BI1 family
FKM99_RS17835	COG2920	part of a sulfur-relay system
FKM99_RS17840	COG1254	Belongs to the acylphosphatase family
FKM99_RS17845	COG0840	transmembrane signaling receptor activity
FKM99_RS17850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FKM99_RS17890	COG3706	GGDEF domain
FKM99_RS17895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FKM99_RS17900	COG0602	queuosine metabolic process
FKM99_RS17905	COG0561	phosphatase activity
FKM99_RS17930	COG2828	Protein conserved in bacteria
FKM99_RS17940	COG0372	Belongs to the citrate synthase family
FKM99_RS17945	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FKM99_RS17975	COG0730	response to heat
FKM99_RS17995	COG0457	Tetratricopeptide repeat
FKM99_RS18065	COG4790	Type iii secretion
FKM99_RS18070	COG4794	Type iii secretion
FKM99_RS18075	COG4791	protein targeting
FKM99_RS18080	COG4792	protein secretion
FKM99_RS18090	COG1073	alpha beta
FKM99_RS18095	COG1073	alpha beta
FKM99_RS18135	COG3177	Filamentation induced by cAMP protein fic
FKM99_RS18155	COG4669	(LipO)protein
FKM99_RS18225	COG1012	belongs to the aldehyde dehydrogenase family
FKM99_RS18230	COG3284	Transcriptional regulator
FKM99_RS18255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FKM99_RS18260	COG0363	glucosamine-6-phosphate deaminase activity
FKM99_RS18265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FKM99_RS18270	COG4565	transcriptional regulatory protein
FKM99_RS18275	COG3290	protein histidine kinase activity
FKM99_RS18290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKM99_RS18305	COG1858	cytochrome C peroxidase
FKM99_RS18320	COG0527	aspartate kinase activity
FKM99_RS18325	COG0662	Cupin 2, conserved barrel domain protein
FKM99_RS18330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FKM99_RS18335	COG0456	acetyltransferase
FKM99_RS18340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FKM99_RS18360	COG4176	ABC-type proline glycine betaine transport system permease component
FKM99_RS18365	COG2113	Glycine betaine
FKM99_RS18380	COG1022	Amp-dependent synthetase and ligase
FKM99_RS18390	COG1028	Short-chain dehydrogenase reductase Sdr
FKM99_RS18400	COG0745	RESPONSE REGULATOR receiver
FKM99_RS18405	COG0642	Histidine kinase
FKM99_RS18410	COG1368	sulfuric ester hydrolase activity
FKM99_RS18435	COG1115	amino acid carrier protein
FKM99_RS18445	COG1280	lysine exporter protein (LysE YggA)
FKM99_RS18460	COG3550	peptidyl-serine autophosphorylation
FKM99_RS18470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FKM99_RS18475	COG1484	DNA-dependent DNA replication
FKM99_RS18480	COG4584	PFAM Integrase catalytic
FKM99_RS18535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FKM99_RS18540	COG0840	transmembrane signaling receptor activity
FKM99_RS18545	COG4580	involved in the transport of maltose and maltodextrins
FKM99_RS18550	COG1874	Beta-galactosidase
FKM99_RS18560	COG3833	ABC-type maltose transport systems, permease component
FKM99_RS18565	COG1175	transmembrane transport
FKM99_RS18570	COG2182	Extracellular solute-binding protein
FKM99_RS18580	COG1609	Transcriptional regulator
FKM99_RS18650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FKM99_RS18660	COG1560	Kdo2-lipid A biosynthetic process
FKM99_RS18670	COG0531	amino acid
FKM99_RS18685	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FKM99_RS18690	COG3063	Type IV pilus biogenesis stability protein PilW
FKM99_RS18720	COG0110	maltose O-acetyltransferase activity
FKM99_RS18740	COG2315	Protein conserved in bacteria
FKM99_RS18745	COG1846	Transcriptional regulator
FKM99_RS18760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FKM99_RS18775	COG2771	luxR family
FKM99_RS18775	COG2200	EAL domain
FKM99_RS18785	COG1227	inorganic diphosphatase activity
FKM99_RS18790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FKM99_RS18795	COG1012	belongs to the aldehyde dehydrogenase family
FKM99_RS18800	COG2957	Belongs to the agmatine deiminase family
FKM99_RS18810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FKM99_RS18815	COG1012	belongs to the aldehyde dehydrogenase family
FKM99_RS18820	COG1396	sequence-specific DNA binding
FKM99_RS18820	COG1917	Cupin 2, conserved barrel domain protein
FKM99_RS18825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FKM99_RS18835	COG0174	glutamine synthetase
FKM99_RS18840	COG1757	Na H antiporter
FKM99_RS18865	COG1280	lysine exporter protein (LysE YggA)
FKM99_RS18910	COG0625	glutathione transferase activity
FKM99_RS18920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FKM99_RS18935	COG2195	Cleaves the N-terminal amino acid of tripeptides
FKM99_RS18945	COG0601	transmembrane transport
FKM99_RS18950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FKM99_RS18955	COG0444	Belongs to the ABC transporter superfamily
FKM99_RS18975	COG3291	Pkd domain containing protein
FKM99_RS18990	COG1177	transmembrane transport
FKM99_RS18995	COG1176	ABC-type spermidine putrescine transport system, permease component I
FKM99_RS19000	COG3842	ATPase activity
FKM99_RS19005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FKM99_RS19010	COG2423	ornithine cyclodeaminase activity
FKM99_RS19030	COG3938	Belongs to the proline racemase family
FKM99_RS19060	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FKM99_RS19065	COG1451	nucleotide metabolic process
FKM99_RS19070	COG3475	LICD family
FKM99_RS19075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FKM99_RS19080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FKM99_RS19100	COG0583	DNA-binding transcription factor activity
FKM99_RS19120	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FKM99_RS19125	COG4139	cobalamin transport
FKM99_RS19130	COG2988	succinylglutamate desuccinylase activity
FKM99_RS19145	COG2062	phosphohistidine phosphatase, SixA
FKM99_RS19155	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FKM99_RS19160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FKM99_RS19165	COG0702	epimerase
FKM99_RS19170	COG1823	symporter activity
FKM99_RS19175	COG2925	Exonuclease
FKM99_RS19180	COG1380	Effector of murein hydrolase LrgA
FKM99_RS19185	COG1346	cytolysis
FKM99_RS19190	COG0295	cytidine deaminase activity
FKM99_RS19195	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FKM99_RS19200	COG0500	methyltransferase
FKM99_RS19210	COG0776	regulation of translation
FKM99_RS19225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FKM99_RS19225	COG0072	phenylalanine-tRNA ligase activity
FKM99_RS19230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FKM99_RS19235	COG3706	GGDEF domain
FKM99_RS19265	COG0393	Putative heavy-metal-binding
FKM99_RS19275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FKM99_RS19285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FKM99_RS19300	COG2188	Transcriptional regulator
FKM99_RS19305	COG1228	amidohydrolase
FKM99_RS19310	COG0010	Belongs to the arginase family
FKM99_RS19315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FKM99_RS19320	COG2986	histidine ammonia-lyase
FKM99_RS19335	COG0247	lactate metabolic process
FKM99_RS19335	COG0277	FAD linked oxidase domain protein
FKM99_RS19370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FKM99_RS19385	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FKM99_RS19390	COG1643	Atp-dependent helicase
FKM99_RS19395	COG0281	malic enzyme
FKM99_RS19400	COG2949	membrane
FKM99_RS19405	COG0471	metal ion transport
FKM99_RS19430	COG0492	ferredoxin-NADP+ reductase activity
FKM99_RS19435	COG4988	ABC transporter
FKM99_RS19440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FKM99_RS19445	COG3048	D-serine ammonia-lyase activity
FKM99_RS19450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FKM99_RS19460	COG4191	Histidine kinase
FKM99_RS19460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FKM99_RS19475	COG3070	regulator of competence-specific genes
FKM99_RS19495	COG2431	L-lysine efflux transmembrane transporter activity
FKM99_RS19505	COG0076	glutamate decarboxylase activity
FKM99_RS19510	COG1737	Transcriptional regulator
FKM99_RS19525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FKM99_RS19530	COG2985	domain, Protein
FKM99_RS19530	COG3273	potassium ion transport
FKM99_RS19535	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FKM99_RS19550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FKM99_RS19565	COG4181	ATPase activity
FKM99_RS19570	COG0534	Mate efflux family protein
FKM99_RS19575	COG0702	epimerase
FKM99_RS19580	COG3005	denitrification pathway
FKM99_RS19610	COG2814	Major facilitator Superfamily
FKM99_RS19615	COG1187	pseudouridine synthase activity
FKM99_RS19620	COG1061	Type III restriction enzyme res subunit
FKM99_RS19640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FKM99_RS19670	COG3313	Fe-S protein
FKM99_RS19695	COG0493	'glutamate synthase
FKM99_RS19705	COG0398	Pfam SNARE associated Golgi protein
FKM99_RS19710	COG4134	Bacterial extracellular solute-binding protein
FKM99_RS19715	COG4135	transport system, permease component
FKM99_RS19720	COG4136	ATPase activity
FKM99_RS19725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FKM99_RS19740	COG3604	Transcriptional regulator
FKM99_RS19745	COG1151	hydroxylamine reductase activity
FKM99_RS19750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FKM99_RS19760	COG0564	pseudouridine synthase activity
FKM99_RS19770	COG0733	neurotransmitter:sodium symporter activity
FKM99_RS19780	COG0626	cystathionine gamma-synthase activity
FKM99_RS19785	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FKM99_RS19790	COG5380	lipid catabolic process
FKM99_RS19795	COG0519	Catalyzes the synthesis of GMP from XMP
FKM99_RS19810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKM99_RS19815	COG1983	PspC domain protein
FKM99_RS19825	COG1842	Phage shock protein A
FKM99_RS19830	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FKM99_RS19845	COG4171	peptide transport system, permease
FKM99_RS19855	COG4172	Belongs to the ABC transporter superfamily
FKM99_RS19865	COG1227	inorganic diphosphatase activity
FKM99_RS19880	COG0243	molybdopterin cofactor binding
FKM99_RS19885	COG3005	denitrification pathway
FKM99_RS19890	COG4459	periplasmic nitrate reductase
FKM99_RS19895	COG0390	transport system, permease component
FKM99_RS19905	COG2116	formate transmembrane transporter activity
FKM99_RS19930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FKM99_RS19935	COG1435	thymidine kinase activity
FKM99_RS19940	COG0215	cysteine-tRNA ligase activity
FKM99_RS19945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FKM99_RS19950	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FKM99_RS19955	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FKM99_RS19965	COG3012	SEC-C Motif Domain Protein
FKM99_RS19970	COG0140	phosphoribosyl-ATP diphosphatase activity
FKM99_RS19970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FKM99_RS19975	COG0107	imidazoleglycerol-phosphate synthase activity
FKM99_RS19980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FKM99_RS19985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FKM99_RS19990	COG0131	Imidazoleglycerol-phosphate dehydratase
FKM99_RS19990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FKM99_RS19995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FKM99_RS20000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FKM99_RS20005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FKM99_RS20020	COG1757	Na H antiporter
FKM99_RS20030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FKM99_RS20040	COG0482	sulfurtransferase activity
FKM99_RS20045	COG2915	High frequency lysogenization protein hflD homolog
FKM99_RS20050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FKM99_RS20075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FKM99_RS20090	COG0300	oxidoreductase activity
FKM99_RS20100	COG0501	Belongs to the peptidase M48B family
FKM99_RS20110	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FKM99_RS20120	COG0156	8-amino-7-oxononanoate synthase activity
FKM99_RS20125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FKM99_RS20130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FKM99_RS20135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FKM99_RS20140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FKM99_RS20145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FKM99_RS20150	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FKM99_RS20155	COG1674	ftsk spoiiie
FKM99_RS20165	COG0686	Belongs to the AlaDH PNT family
FKM99_RS20175	COG0583	DNA-binding transcription factor activity
FKM99_RS20190	COG3568	Endonuclease Exonuclease Phosphatase
FKM99_RS20220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKM99_RS20225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKM99_RS20240	COG0840	transmembrane signaling receptor activity
FKM99_RS20255	COG0784	Response regulator, receiver
FKM99_RS20255	COG5002	protein histidine kinase activity
FKM99_RS20265	COG0754	glutathionylspermidine amidase activity
FKM99_RS20275	COG3766	membrane
FKM99_RS20285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FKM99_RS20290	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FKM99_RS20295	COG2885	chlorophyll binding
FKM99_RS20300	COG0823	Involved in the tonB-independent uptake of proteins
FKM99_RS20315	COG0811	peptide transport
FKM99_RS20320	COG0824	Thioesterase
FKM99_RS20330	COG4890	Cyd operon protein YbgT
FKM99_RS20335	COG1294	oxidase, subunit
FKM99_RS20340	COG1271	oxidase subunit
FKM99_RS20345	COG2255	four-way junction helicase activity
FKM99_RS20350	COG0632	four-way junction helicase activity
FKM99_RS20355	COG0840	transmembrane signaling receptor activity
FKM99_RS20360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FKM99_RS20365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FKM99_RS20370	COG1801	Protein of unknown function DUF72
FKM99_RS20375	COG4106	trans-aconitate 2-methyltransferase activity
FKM99_RS20380	COG0500	methyltransferase
FKM99_RS20390	COG0189	ligase activity
FKM99_RS20390	COG4067	protein conserved in archaea
FKM99_RS20410	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FKM99_RS20415	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FKM99_RS20420	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FKM99_RS20425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FKM99_RS20430	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FKM99_RS20435	COG0745	RESPONSE REGULATOR receiver
FKM99_RS20440	COG3381	protein complex oligomerization
FKM99_RS20445	COG1609	Transcriptional regulator
FKM99_RS20450	COG3070	regulator of competence-specific genes
FKM99_RS20455	COG4584	PFAM Integrase catalytic
FKM99_RS20460	COG1484	DNA-dependent DNA replication
FKM99_RS20480	COG0297	glycogen (starch) synthase activity
FKM99_RS20485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FKM99_RS20490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FKM99_RS20500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FKM99_RS20510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FKM99_RS20515	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FKM99_RS20520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FKM99_RS20530	COG0542	response to heat
FKM99_RS20535	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FKM99_RS20540	COG1278	Cold shock
FKM99_RS20550	COG1187	pseudouridine synthase activity
FKM99_RS20555	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FKM99_RS20565	COG1199	ATP-dependent helicase activity
FKM99_RS20570	COG0730	response to heat
FKM99_RS20575	COG3923	Primosomal replication protein n
FKM99_RS20585	COG0708	Exodeoxyribonuclease III
FKM99_RS20630	COG1882	Formate acetyltransferase
FKM99_RS20640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FKM99_RS20650	COG3013	Belongs to the UPF0304 family
FKM99_RS20660	COG2766	serine protein kinase
FKM99_RS20665	COG2718	Belongs to the UPF0229 family
FKM99_RS20670	COG2719	SpoVR family
FKM99_RS20675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FKM99_RS20685	COG1663	tetraacyldisaccharide 4'-kinase activity
FKM99_RS20690	COG1132	(ABC) transporter
FKM99_RS20695	COG0658	competence protein
FKM99_RS20695	COG2333	competence protein COMEC
FKM99_RS20705	COG4591	ABC-type transport system involved in lipoprotein release permease component
FKM99_RS20710	COG1136	(ABC) transporter
FKM99_RS20715	COG4591	ABC-type transport system involved in lipoprotein release permease component
FKM99_RS20725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FKM99_RS20745	COG1252	NADH dehydrogenase
FKM99_RS20755	COG3150	esterase
FKM99_RS20780	COG0537	adenosine 5'-monophosphoramidase activity
FKM99_RS20810	COG0516	GMP reductase activity
FKM99_RS20810	COG0517	IMP dehydrogenase activity
FKM99_RS20820	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FKM99_RS20825	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FKM99_RS20830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FKM99_RS20840	COG2199	diguanylate cyclase activity
FKM99_RS20855	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FKM99_RS20860	COG1946	Acyl-CoA thioesterase
FKM99_RS20870	COG1522	sequence-specific DNA binding
FKM99_RS20900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKM99_RS20905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKM99_RS20930	COG0477	Major facilitator Superfamily
FKM99_RS20935	COG2855	membrane
FKM99_RS20955	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FKM99_RS20960	COG0596	Alpha beta hydrolase
FKM99_RS20965	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FKM99_RS20970	COG1169	isochorismate synthase
FKM99_RS20975	COG0436	Aminotransferase
FKM99_RS20980	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FKM99_RS20985	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FKM99_RS21000	COG1555	photosystem II stabilization
FKM99_RS21005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FKM99_RS21010	COG0776	regulation of translation
FKM99_RS21015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FKM99_RS21020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FKM99_RS21030	COG0544	peptidyl-prolyl cis-trans isomerase activity
FKM99_RS21040	COG2204	response regulator
FKM99_RS21050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FKM99_RS21055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FKM99_RS21060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKM99_RS21065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FKM99_RS21080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FKM99_RS21085	COG0569	domain protein
FKM99_RS21090	COG0513	Belongs to the DEAD box helicase family
FKM99_RS21095	COG1253	flavin adenine dinucleotide binding
FKM99_RS21130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FKM99_RS21135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FKM99_RS21150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FKM99_RS21155	COG1216	Glycosyl transferase, family 2
FKM99_RS21160	COG2986	histidine ammonia-lyase
FKM99_RS21185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FKM99_RS21195	COG1028	Short-chain dehydrogenase reductase Sdr
FKM99_RS21215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FKM99_RS21220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FKM99_RS21225	COG0583	DNA-binding transcription factor activity
FKM99_RS21230	COG2951	lytic endotransglycosylase activity
FKM99_RS21235	COG3100	YcgL domain-containing protein
FKM99_RS21240	COG0850	regulation of cytokinetic process
FKM99_RS21245	COG2894	cell division
FKM99_RS21250	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FKM99_RS21255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FKM99_RS21260	COG0318	PFAM AMP-dependent synthetase and ligase
FKM99_RS21265	COG2267	carboxylic ester hydrolase activity
FKM99_RS21280	COG1214	PFAM Peptidase M22, glycoprotease
FKM99_RS21285	COG1199	ATP-dependent helicase activity
FKM99_RS21290	COG0788	formyltetrahydrofolate deformylase activity
FKM99_RS21295	COG3102	Protein conserved in bacteria
FKM99_RS21305	COG0018	arginyl-trna synthetase
FKM99_RS21325	COG1918	ferrous iron import across plasma membrane
FKM99_RS21340	COG4977	sequence-specific DNA binding
FKM99_RS21345	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FKM99_RS21350	COG1121	(ABC) transporter
FKM99_RS21355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FKM99_RS21360	COG0121	glutamine amidotransferase
FKM99_RS21365	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FKM99_RS21370	COG1960	acyl-CoA dehydrogenase activity
FKM99_RS21380	COG0456	acetyltransferase
FKM99_RS21400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FKM99_RS21405	COG0328	RNA-DNA hybrid ribonuclease activity
FKM99_RS21410	COG2226	methyltransferase
FKM99_RS21415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FKM99_RS21420	COG0741	lytic transglycosylase activity
FKM99_RS21420	COG1388	LysM domain
FKM99_RS21430	COG3021	interspecies interaction between organisms
FKM99_RS21435	COG0347	Belongs to the P(II) protein family
FKM99_RS21445	COG0037	tRNA processing
FKM99_RS21450	COG0825	malonyl-CoA metabolic process
FKM99_RS21455	COG0587	DNA-directed DNA polymerase activity
FKM99_RS21465	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FKM99_RS21470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FKM99_RS21475	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FKM99_RS21480	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FKM99_RS21490	COG0750	zinc metalloprotease
FKM99_RS21495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FKM99_RS21500	COG0575	Belongs to the CDS family
FKM99_RS21505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FKM99_RS21510	COG0233	cytoplasmic translational termination
FKM99_RS21515	COG0528	UMP kinase activity
FKM99_RS21520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FKM99_RS21525	COG0052	Belongs to the universal ribosomal protein uS2 family
FKM99_RS21530	COG0024	Methionine aminopeptidase
FKM99_RS21535	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FKM99_RS21545	COG0564	pseudouridine synthase activity
FKM99_RS21550	COG3098	single-species biofilm formation
FKM99_RS21575	COG1671	Belongs to the UPF0178 family
FKM99_RS21580	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FKM99_RS21590	COG0254	rRNA binding
FKM99_RS21595	COG1720	tRNA m6t6A37 methyltransferase activity
FKM99_RS21600	COG0442	prolyl-tRNA aminoacylation
FKM99_RS21620	COG0733	neurotransmitter:sodium symporter activity
FKM99_RS21640	COG0514	ATP-dependent DNA helicase (RecQ)
FKM99_RS21645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FKM99_RS21660	COG1477	protein flavinylation
FKM99_RS21665	COG2871	sodium ion transport
FKM99_RS21670	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FKM99_RS21675	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FKM99_RS21680	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FKM99_RS21685	COG1805	sodium ion transport
FKM99_RS21690	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FKM99_RS21695	COG0271	Belongs to the BolA IbaG family
FKM99_RS21700	COG2813	Specifically methylates the guanine in position
FKM99_RS21705	COG3056	Lipoprotein
FKM99_RS21725	COG1595	DNA-templated transcription, initiation
FKM99_RS21755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FKM99_RS21760	COG0693	protein deglycase activity
FKM99_RS21765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FKM99_RS21770	COG3706	GGDEF domain
FKM99_RS21775	COG2166	iron-sulfur cluster assembly
FKM99_RS21780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FKM99_RS21785	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FKM99_RS21800	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FKM99_RS21800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FKM99_RS21810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FKM99_RS21815	COG1074	ATP-dependent DNA helicase activity
FKM99_RS21825	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FKM99_RS21845	COG3141	response to X-ray
FKM99_RS21850	COG2171	N-acyltransferase activity
FKM99_RS21855	COG0584	glycerophosphoryl diester phosphodiesterase
FKM99_RS21860	COG2271	Major facilitator Superfamily
FKM99_RS21875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FKM99_RS21880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FKM99_RS21885	COG1349	DNA-binding transcription factor activity
FKM99_RS21890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FKM99_RS21895	COG0598	Magnesium transport protein CorA
FKM99_RS21910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FKM99_RS21915	COG1609	Transcriptional regulator
FKM99_RS21920	COG2211	Major facilitator Superfamily
FKM99_RS21935	COG2017	converts alpha-aldose to the beta-anomer
FKM99_RS21940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FKM99_RS21950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FKM99_RS21960	COG1609	Transcriptional regulator
FKM99_RS21965	COG3250	beta-galactosidase activity
FKM99_RS21970	COG2731	YhcH YjgK YiaL family protein
FKM99_RS21975	COG0531	amino acid
FKM99_RS21980	COG0583	DNA-binding transcription factor activity
FKM99_RS22045	COG4964	Belongs to the GSP D family
FKM99_RS22065	COG0583	DNA-binding transcription factor activity
FKM99_RS22105	COG1022	Amp-dependent synthetase and ligase
FKM99_RS22115	COG0583	DNA-binding transcription factor activity
FKM99_RS22120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FKM99_RS22125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FKM99_RS22135	COG0560	Phosphoserine phosphatase
FKM99_RS22145	COG0813	purine-nucleoside phosphorylase activity
FKM99_RS22150	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FKM99_RS22155	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FKM99_RS22160	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FKM99_RS22165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FKM99_RS22170	COG0084	hydrolase, TatD family'
FKM99_RS22180	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FKM99_RS22260	COG2003	Belongs to the UPF0758 family
FKM99_RS22285	COG0714	Associated with various cellular activities
FKM99_RS22300	COG0629	single-stranded DNA binding
FKM99_RS22315	COG2356	endonuclease I
FKM99_RS22345	COG0786	glutamate:sodium symporter activity
FKM99_RS22360	COG0640	Transcriptional regulator
FKM99_RS22410	COG0681	Belongs to the peptidase S26 family
FKM99_RS22425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FKM99_RS22535	COG2176	DNA-directed DNA polymerase activity
FKM99_RS22540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FKM99_RS22580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FKM99_RS22600	COG3153	acetyltransferase
FKM99_RS22605	COG3154	lipid carrier protein
FKM99_RS22615	COG0826	peptidase U32
FKM99_RS22620	COG0826	peptidase U32
FKM99_RS22625	COG0534	Mate efflux family protein
FKM99_RS22640	COG1185	polyribonucleotide nucleotidyltransferase activity
FKM99_RS22645	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FKM99_RS22650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FKM99_RS22655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FKM99_RS22660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FKM99_RS22665	COG0195	Participates in both transcription termination and antitermination
FKM99_RS22670	COG0779	Required for maturation of 30S ribosomal subunits
FKM99_RS22685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FKM99_RS22695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FKM99_RS22700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FKM99_RS22705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FKM99_RS22710	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FKM99_RS22715	COG1534	Rna-binding protein
FKM99_RS22720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FKM99_RS22725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FKM99_RS22730	COG2027	D-alanyl-D-alanine carboxypeptidase
FKM99_RS22740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FKM99_RS22745	COG0739	heme binding
FKM99_RS22750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKM99_RS22760	COG0316	Belongs to the HesB IscA family
FKM99_RS22765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FKM99_RS22770	COG0628	permease
FKM99_RS22775	COG2813	Specifically methylates the guanine in position
FKM99_RS22785	COG2205	protein histidine kinase activity
FKM99_RS22785	COG0784	Response regulator, receiver
FKM99_RS22785	COG2198	Histidine kinase
FKM99_RS22785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FKM99_RS22790	COG0747	negative chemotaxis
FKM99_RS22800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FKM99_RS22805	COG0444	Belongs to the ABC transporter superfamily
FKM99_RS22810	COG4608	Belongs to the ABC transporter superfamily
FKM99_RS22820	COG2971	BadF BadG BcrA BcrD
FKM99_RS22835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FKM99_RS22840	COG3842	ATPase activity
FKM99_RS22850	COG1840	ABC-type Fe3 transport system, periplasmic component
FKM99_RS22855	COG0004	ammonium transporteR
FKM99_RS22865	COG3112	Uncharacterised protein family (UPF0231)
FKM99_RS22870	COG1049	propionate catabolic process, 2-methylcitrate cycle
FKM99_RS22875	COG1752	Esterase of the alpha-beta hydrolase superfamily
FKM99_RS22880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FKM99_RS22885	COG1643	Atp-dependent helicase
FKM99_RS22890	COG1489	DNA binding
FKM99_RS22905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FKM99_RS22920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FKM99_RS22925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FKM99_RS22930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FKM99_RS22940	COG1560	Kdo2-lipid A biosynthetic process
FKM99_RS22950	COG0842	Transport permease protein
FKM99_RS22955	COG1131	(ABC) transporter
FKM99_RS22965	COG0659	secondary active sulfate transmembrane transporter activity
FKM99_RS22970	COG0288	reversible hydration of carbon dioxide
FKM99_RS22985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FKM99_RS22990	COG0508	dehydrogenase complex catalyzes the overall conversion of
FKM99_RS22995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FKM99_RS23000	COG2186	Transcriptional regulator
FKM99_RS23010	COG0157	Belongs to the NadC ModD family
FKM99_RS23020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FKM99_RS23025	COG1459	type II secretion system
FKM99_RS23035	COG0237	dephospho-CoA kinase activity
FKM99_RS23040	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FKM99_RS23045	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FKM99_RS23050	COG0335	large ribosomal subunit rRNA binding
FKM99_RS23055	COG0336	Belongs to the RNA methyltransferase TrmD family
FKM99_RS23060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FKM99_RS23065	COG0228	four-way junction DNA binding
FKM99_RS23070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FKM99_RS23075	COG4137	Cytochrome C assembly protein
FKM99_RS23080	COG4536	flavin adenine dinucleotide binding
FKM99_RS23085	COG1854	S-ribosylhomocysteine lyase activity
FKM99_RS23095	COG2918	glutathione biosynthetic process
FKM99_RS23100	COG0612	Peptidase, M16
FKM99_RS23105	COG1238	metal cluster binding
FKM99_RS23115	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FKM99_RS23120	COG0511	ligase activity, forming carbon-carbon bonds
FKM99_RS23120	COG5016	pyruvate
FKM99_RS23125	COG3630	sodium ion export across plasma membrane
FKM99_RS23150	COG0527	aspartate kinase activity
FKM99_RS23155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FKM99_RS23160	COG2137	regulation of response to DNA damage stimulus
FKM99_RS23165	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FKM99_RS23170	COG1546	Belongs to the CinA family
FKM99_RS23175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FKM99_RS23190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FKM99_RS23195	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FKM99_RS23200	COG0585	pseudouridine synthase activity
FKM99_RS23205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FKM99_RS23210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FKM99_RS23215	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FKM99_RS23220	COG0148	phosphopyruvate hydratase activity
FKM99_RS23225	COG0504	CTP synthase activity
FKM99_RS23230	COG3956	TIGRFAM MazG family protein
FKM99_RS23235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FKM99_RS23245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FKM99_RS23260	COG0736	holo-[acyl-carrier-protein] synthase activity
FKM99_RS23265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FKM99_RS23270	COG1381	Involved in DNA repair and RecF pathway recombination
FKM99_RS23275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FKM99_RS23280	COG0571	ribonuclease III activity
FKM99_RS23290	COG0481	GTPase activity
FKM99_RS23295	COG3086	response to oxidative stress
FKM99_RS23305	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FKM99_RS23310	COG1595	DNA-templated transcription, initiation
FKM99_RS23320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FKM99_RS23330	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FKM99_RS23335	COG0354	folic acid binding
FKM99_RS23350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FKM99_RS23355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FKM99_RS23360	COG3079	Belongs to the UPF0149 family
FKM99_RS23370	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FKM99_RS23380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FKM99_RS23385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FKM99_RS23390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FKM99_RS23400	COG0583	DNA-binding transcription factor activity
FKM99_RS23415	COG0668	transmembrane transport
FKM99_RS23420	COG0191	fructose-bisphosphate aldolase activity
FKM99_RS23430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FKM99_RS23435	COG4771	TonB-dependent receptor
FKM99_RS23440	COG0583	DNA-binding transcription factor activity
FKM99_RS23445	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FKM99_RS23455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FKM99_RS23465	COG3091	SprT-like family
FKM99_RS23470	COG2356	endonuclease I
FKM99_RS23475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FKM99_RS23480	COG0189	ligase activity
FKM99_RS23485	COG1678	Uncharacterized ACR, COG1678
FKM99_RS23490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FKM99_RS23505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FKM99_RS23510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FKM99_RS23515	COG0762	integral membrane protein
FKM99_RS23520	COG1872	DUF167
FKM99_RS23530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FKM99_RS23535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FKM99_RS23540	COG2066	Belongs to the glutaminase family
FKM99_RS23550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FKM99_RS23560	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FKM99_RS23565	COG0741	lytic transglycosylase activity
FKM99_RS23635	COG1012	belongs to the aldehyde dehydrogenase family
FKM99_RS23685	COG3437	response regulator, receiver
FKM99_RS23695	COG3394	polysaccharide catabolic process
FKM99_RS23700	COG1486	melibiose metabolic process
FKM99_RS23705	COG1447	Phosphotransferase system cellobiose-specific component IIA
FKM99_RS23710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FKM99_RS23715	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FKM99_RS23720	COG0726	polysaccharide deacetylase
FKM99_RS23735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FKM99_RS23740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FKM99_RS23840	COG1028	Short-chain dehydrogenase reductase Sdr
FKM99_RS23855	COG0795	lipopolysaccharide-transporting ATPase activity
FKM99_RS23860	COG0795	lipopolysaccharide-transporting ATPase activity
FKM99_RS23865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FKM99_RS23870	COG2927	DNA polymerase III (CHI subunit)
FKM99_RS23875	COG0525	valine-tRNA ligase activity
FKM99_RS23905	COG2235	arginine
FKM99_RS23910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FKM99_RS23920	COG0540	Belongs to the ATCase OTCase family
FKM99_RS23925	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FKM99_RS23930	COG0251	oxidation-reduction process
FKM99_RS23935	COG0204	Acyl-transferase
FKM99_RS23940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FKM99_RS23945	COG5007	Belongs to the BolA IbaG family
FKM99_RS23955	COG2854	intermembrane phospholipid transfer
FKM99_RS23960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FKM99_RS23965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FKM99_RS23970	COG1127	ABC transporter
FKM99_RS23980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FKM99_RS23980	COG0517	IMP dehydrogenase activity
FKM99_RS23990	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FKM99_RS23995	COG1137	ATPase activity
FKM99_RS24005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FKM99_RS24010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FKM99_RS24015	COG1660	Displays ATPase and GTPase activities
FKM99_RS24020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FKM99_RS24025	COG2239	Acts as a magnesium transporter
FKM99_RS24030	COG0312	modulator of DNA gyrase
FKM99_RS24035	COG3028	Belongs to the UPF0307 family
FKM99_RS24040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FKM99_RS24045	COG0564	pseudouridine synthase activity
FKM99_RS24060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FKM99_RS24065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FKM99_RS24070	COG0312	modulator of DNA gyrase
FKM99_RS24075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FKM99_RS24080	COG3164	Protein of unknown function
FKM99_RS24090	COG0424	maF-like protein
FKM99_RS24095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FKM99_RS24100	COG1792	Involved in formation and maintenance of cell shape
FKM99_RS24105	COG1077	Cell shape determining protein MreB Mrl
FKM99_RS24140	COG2165	general secretion pathway protein
FKM99_RS24150	COG1459	type II secretion system
FKM99_RS24155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FKM99_RS24165	COG3267	Type II secretory pathway component ExeA
FKM99_RS24165	COG3409	Peptidoglycan-binding domain 1 protein
FKM99_RS24190	COG2200	EAL domain
FKM99_RS24190	COG2199	diguanylate cyclase activity
FKM99_RS24220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FKM99_RS24265	COG0840	transmembrane signaling receptor activity
FKM99_RS24290	COG1061	Type III restriction enzyme res subunit
FKM99_RS24315	COG0629	single-stranded DNA binding
FKM99_RS24330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FKM99_RS24340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FKM99_RS24350	COG0527	aspartate kinase activity
FKM99_RS24355	COG0646	methionine synthase
FKM99_RS24355	COG1410	methionine synthase
FKM99_RS24435	COG0175	sulfate reduction
FKM99_RS24440	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FKM99_RS24445	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FKM99_RS24470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FKM99_RS24490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FKM99_RS24545	COG0735	belongs to the Fur family
FKM99_RS24555	COG0166	Belongs to the GPI family
FKM99_RS24560	COG0432	Pfam Uncharacterised protein family UPF0047
FKM99_RS24570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FKM99_RS24585	COG0359	binds to the 23S rRNA
FKM99_RS24595	COG2965	DNA replication, synthesis of RNA primer
FKM99_RS24600	COG0360	Binds together with S18 to 16S ribosomal RNA
FKM99_RS24605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FKM99_RS24610	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FKM99_RS24620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FKM99_RS24625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FKM99_RS24655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FKM99_RS24665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FKM99_RS24665	COG0678	peroxiredoxin activity
FKM99_RS24680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FKM99_RS24680	COG0165	Argininosuccinate lyase
FKM99_RS24685	COG0137	argininosuccinate synthase activity
FKM99_RS24690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FKM99_RS24695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FKM99_RS24700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FKM99_RS24705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FKM99_RS24715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FKM99_RS24720	COG0527	aspartate kinase activity
FKM99_RS24720	COG0460	homoserine dehydrogenase
FKM99_RS24725	COG0626	cystathionine gamma-synthase activity
FKM99_RS24735	COG0281	malic enzyme
FKM99_RS24745	COG2906	2 iron, 2 sulfur cluster binding
FKM99_RS24750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FKM99_RS24755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FKM99_RS24760	COG0049	tRNA binding
FKM99_RS24770	COG2168	tRNA wobble position uridine thiolation
FKM99_RS24775	COG2923	Belongs to the DsrF TusC family
FKM99_RS24780	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FKM99_RS24785	COG2964	Protein conserved in bacteria
FKM99_RS24790	COG0545	Peptidyl-prolyl cis-trans isomerase
FKM99_RS24800	COG2900	Belongs to the SlyX family
FKM99_RS24805	COG1446	asparaginase
FKM99_RS24815	COG1047	Peptidyl-prolyl cis-trans
FKM99_RS24830	COG2249	NAD(P)H dehydrogenase (quinone) activity
FKM99_RS24840	COG0488	(ABC) transporter
FKM99_RS24850	COG0429	hydrolase of the alpha beta-hydrolase fold
FKM99_RS24855	COG3089	Belongs to the UPF0270 family
FKM99_RS24860	COG3954	Phosphoribulokinase
FKM99_RS24865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FKM99_RS24875	COG1012	belongs to the aldehyde dehydrogenase family
FKM99_RS24885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FKM99_RS24890	COG0512	Glutamine amidotransferase of anthranilate synthase
FKM99_RS24920	COG0180	Tryptophanyl-tRNA synthetase
FKM99_RS24925	COG0546	phosphoglycolate phosphatase activity
FKM99_RS24930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FKM99_RS24935	COG0557	exoribonuclease II activity
FKM99_RS24940	COG1959	2 iron, 2 sulfur cluster binding
FKM99_RS24945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FKM99_RS24945	COG1017	nitric oxide dioxygenase activity
FKM99_RS24950	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FKM99_RS24960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FKM99_RS24965	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FKM99_RS24970	COG0330	HflC and HflK could
FKM99_RS24975	COG0330	HflC and HflK could
FKM99_RS24980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FKM99_RS24990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FKM99_RS24995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FKM99_RS25000	COG0860	N-Acetylmuramoyl-L-alanine amidase
FKM99_RS25005	COG0802	atpase or kinase
FKM99_RS25010	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FKM99_RS25040	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FKM99_RS25045	COG1162	GTPase activity
FKM99_RS25050	COG0688	phosphatidylethanolamine metabolic process
FKM99_RS25055	COG0471	metal ion transport
FKM99_RS25070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FKM99_RS25080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FKM99_RS25085	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FKM99_RS25090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FKM99_RS25095	COG1045	serine acetyltransferase
FKM99_RS25100	COG4942	peptidase
FKM99_RS25120	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FKM99_RS25130	COG1053	succinate dehydrogenase
FKM99_RS25135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FKM99_RS25140	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FKM99_RS25145	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FKM99_RS25155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FKM99_RS25160	COG1509	lysine 2,3-aminomutase activity
FKM99_RS25175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FKM99_RS25190	COG0459	protein refolding
FKM99_RS25200	COG0534	Mate efflux family protein
FKM99_RS25205	COG0205	6-phosphofructokinase activity
FKM99_RS25215	COG3678	ATP-independent chaperone mediated protein folding
FKM99_RS25225	COG0745	RESPONSE REGULATOR receiver
FKM99_RS25230	COG2205	protein histidine kinase activity
FKM99_RS25240	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FKM99_RS25245	COG3030	protein affecting phage T7 exclusion by the F plasmid
FKM99_RS25250	COG1027	Aspartate ammonia-lyase
FKM99_RS25255	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FKM99_RS25260	COG4232	protein-disulfide reductase activity
FKM99_RS25270	COG3263	regulation of cellular component size
FKM99_RS25280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FKM99_RS25305	COG2205	protein histidine kinase activity
FKM99_RS25305	COG2198	Histidine kinase
FKM99_RS25305	COG0784	Response regulator, receiver
FKM99_RS25310	COG2814	Major facilitator Superfamily
FKM99_RS25325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FKM99_RS25330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FKM99_RS25335	COG0511	ligase activity, forming carbon-carbon bonds
FKM99_RS25340	COG0439	Biotin carboxylase
FKM99_RS25350	COG2264	protein methyltransferase activity
FKM99_RS25355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FKM99_RS25360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FKM99_RS25365	COG2814	Major facilitator Superfamily
FKM99_RS25370	COG0488	(ABC) transporter
FKM99_RS25375	COG3706	GGDEF domain
FKM99_RS25445	COG1982	Orn Lys Arg decarboxylase major
FKM99_RS25450	COG0531	amino acid
FKM99_RS25460	COG3710	Transcriptional regulator
FKM99_RS25465	COG0789	Transcriptional regulator
FKM99_RS25475	COG0138	bifunctional purine biosynthesis protein purh
FKM99_RS25485	COG0151	Belongs to the GarS family
FKM99_RS25500	COG1253	flavin adenine dinucleotide binding
FKM99_RS25510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FKM99_RS25515	COG1573	uracil-dna glycosylase
FKM99_RS25520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FKM99_RS25535	COG2816	NAD+ diphosphatase activity
FKM99_RS25540	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FKM99_RS25545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FKM99_RS25550	COG0085	RNA polymerase activity
FKM99_RS25555	COG0222	ribosome binding
FKM99_RS25560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FKM99_RS25565	COG0081	regulation of translation
FKM99_RS25570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FKM99_RS25575	COG0250	Participates in transcription elongation, termination and antitermination
FKM99_RS25580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FKM99_RS25590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FKM99_RS25625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FKM99_RS25635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FKM99_RS25705	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FKM99_RS25715	COG4206	TonB-dependent receptor
FKM99_RS25720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FKM99_RS25735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FKM99_RS25740	COG0534	Mate efflux family protein
FKM99_RS25745	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FKM99_RS25750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FKM99_RS25765	COG2937	Belongs to the GPAT DAPAT family
FKM99_RS25770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FKM99_RS25775	COG3161	chorismate lyase activity
FKM99_RS25780	COG1580	Controls the rotational direction of flagella during chemotaxis
FKM99_RS25785	COG0705	Rhomboid family
FKM99_RS25790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FKM99_RS25805	COG2177	Part of the ABC transporter FtsEX involved in
FKM99_RS25810	COG2884	Cell division ATP-binding protein ftsE
FKM99_RS25815	COG0552	protein localization to endoplasmic reticulum
FKM99_RS25820	COG0742	ribosomal rna small subunit methyltransferase
FKM99_RS25830	COG2095	MarC family integral membrane protein
FKM99_RS25885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FKM99_RS25890	COG0640	Transcriptional regulator
FKM99_RS25895	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FKM99_RS25900	COG1280	lysine exporter protein (LysE YggA)
FKM99_RS25905	COG2267	carboxylic ester hydrolase activity
FKM99_RS25915	COG0561	phosphatase activity
FKM99_RS25930	COG3148	PFAM DTW domain containing protein
FKM99_RS25935	COG2199	diguanylate cyclase activity
FKM99_RS25935	COG2200	EAL domain
FKM99_RS25935	COG3287	FIST C domain
FKM99_RS25940	COG1011	Hydrolase
FKM99_RS25945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FKM99_RS25955	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FKM99_RS25960	COG0019	diaminopimelate decarboxylase activity
FKM99_RS25970	COG1965	Belongs to the frataxin family
FKM99_RS25975	COG3072	Adenylate cyclase
FKM99_RS25980	COG0181	hydroxymethylbilane synthase activity
FKM99_RS25985	COG1587	Uroporphyrinogen-III synthase
FKM99_RS25990	COG2959	enzyme of heme biosynthesis
FKM99_RS25995	COG3071	HemY protein
FKM99_RS26045	COG0633	Ferredoxin
FKM99_RS26050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FKM99_RS26070	COG3118	belongs to the thioredoxin family
FKM99_RS26075	COG0513	Belongs to the DEAD box helicase family
FKM99_RS26080	COG0248	Ppx GppA phosphatase
FKM99_RS26085	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FKM99_RS26100	COG0514	ATP-dependent DNA helicase (RecQ)
FKM99_RS26105	COG2962	Rard protein
FKM99_RS26115	COG1280	lysine exporter protein (LysE YggA)
FKM99_RS26120	COG0405	Gamma-glutamyltransferase
FKM99_RS26130	COG0210	DNA helicase
FKM99_RS26140	COG3220	belongs to the UPF0276 family
FKM99_RS26170	COG0006	proline dipeptidase activity
FKM99_RS26170	COG0006	proline dipeptidase activity
FKM99_RS26180	COG2022	thiamine diphosphate biosynthetic process
FKM99_RS26185	COG2104	thiamine diphosphate biosynthetic process
FKM99_RS26190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FKM99_RS26195	COG0352	thiamine-phosphate diphosphorylase activity
FKM99_RS26200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FKM99_RS26205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FKM99_RS26260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FKM99_RS26270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FKM99_RS26275	COG0408	coproporphyrinogen oxidase activity
FKM99_RS26280	COG0009	L-threonylcarbamoyladenylate synthase
FKM99_RS26285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FKM99_RS26290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FKM99_RS26295	COG0551	DNA topoisomerase type I activity
FKM99_RS26300	COG2922	Belongs to the Smg family
FKM99_RS26305	COG0758	DNA mediated transformation
FKM99_RS26315	COG0242	peptide deformylase activity
FKM99_RS26320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FKM99_RS26325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FKM99_RS26325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FKM99_RS26330	COG0569	domain protein
FKM99_RS26335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FKM99_RS26345	COG1272	protein, Hemolysin III
FKM99_RS26350	COG4326	sporulation control protein
FKM99_RS26360	COG3084	Protein conserved in bacteria
FKM99_RS26370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FKM99_RS26375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FKM99_RS26380	COG0204	Acyl-transferase
FKM99_RS26390	COG0606	chelatase, subunit chli
FKM99_RS26400	COG3978	acetolactate synthase activity
FKM99_RS26405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FKM99_RS26410	COG0129	dihydroxy-acid dehydratase activity
FKM99_RS26420	COG0583	DNA-binding transcription factor activity
FKM99_RS26425	COG2814	Major facilitator Superfamily
FKM99_RS26430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FKM99_RS26435	COG0765	amino acid transport
FKM99_RS26440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FKM99_RS26445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FKM99_RS26450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FKM99_RS26455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FKM99_RS26460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FKM99_RS26465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FKM99_RS26480	COG0356	it plays a direct role in the translocation of protons across the membrane
FKM99_RS26485	COG3312	ion transport
FKM99_RS26490	COG1475	DNA binding
FKM99_RS26495	COG1192	Involved in chromosome partitioning
FKM99_RS26500	COG0357	Ribosomal RNA small subunit methyltransferase G
FKM99_RS26505	COG0445	tRNA wobble uridine modification
FKM99_RS26510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FKM99_RS26530	COG1395	domain, Protein
FKM99_RS26585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FKM99_RS26610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FKM99_RS26635	COG4974	Belongs to the 'phage' integrase family
FKM99_RS26640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FKM99_RS26645	COG0706	membrane insertase activity
FKM99_RS26655	COG0594	ribonuclease P activity
FKM99_RS26665	COG1126	abc transporter atp-binding protein