locus-tag	class	description
H9J99_RS00050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9J99_RS00060	COG4206	TonB-dependent receptor
H9J99_RS00065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9J99_RS00105	COG3339	Conserved Protein
H9J99_RS00145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9J99_RS00180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9J99_RS00185	COG0534	Mate efflux family protein
H9J99_RS00190	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H9J99_RS00195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9J99_RS00200	COG2937	Belongs to the GPAT DAPAT family
H9J99_RS00205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H9J99_RS00210	COG3161	chorismate lyase activity
H9J99_RS00215	COG1580	Controls the rotational direction of flagella during chemotaxis
H9J99_RS00220	COG0705	Rhomboid family
H9J99_RS00225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9J99_RS00235	COG2177	Part of the ABC transporter FtsEX involved in
H9J99_RS00240	COG2884	Cell division ATP-binding protein ftsE
H9J99_RS00245	COG0552	protein localization to endoplasmic reticulum
H9J99_RS00250	COG0742	ribosomal rna small subunit methyltransferase
H9J99_RS00260	COG2095	MarC family integral membrane protein
H9J99_RS00310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9J99_RS00315	COG0640	Transcriptional regulator
H9J99_RS00320	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H9J99_RS00325	COG1280	lysine exporter protein (LysE YggA)
H9J99_RS00330	COG2267	carboxylic ester hydrolase activity
H9J99_RS00335	COG0561	phosphatase activity
H9J99_RS00350	COG3148	PFAM DTW domain containing protein
H9J99_RS00355	COG3287	FIST C domain
H9J99_RS00355	COG2200	EAL domain
H9J99_RS00355	COG2199	diguanylate cyclase activity
H9J99_RS00360	COG1011	Hydrolase
H9J99_RS00375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9J99_RS00380	COG0019	diaminopimelate decarboxylase activity
H9J99_RS00390	COG1965	Belongs to the frataxin family
H9J99_RS00395	COG3072	Adenylate cyclase
H9J99_RS00400	COG0181	hydroxymethylbilane synthase activity
H9J99_RS00405	COG1587	Uroporphyrinogen-III synthase
H9J99_RS00415	COG3071	HemY protein
H9J99_RS00460	COG0633	Ferredoxin
H9J99_RS00465	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H9J99_RS00480	COG3118	belongs to the thioredoxin family
H9J99_RS00485	COG0513	Belongs to the DEAD box helicase family
H9J99_RS00490	COG0248	Ppx GppA phosphatase
H9J99_RS00495	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H9J99_RS00505	COG0514	ATP-dependent DNA helicase (RecQ)
H9J99_RS00510	COG2962	Rard protein
H9J99_RS00520	COG1280	lysine exporter protein (LysE YggA)
H9J99_RS00525	COG0405	Gamma-glutamyltransferase
H9J99_RS00530	COG0210	DNA helicase
H9J99_RS00540	COG3220	belongs to the UPF0276 family
H9J99_RS00570	COG0006	proline dipeptidase activity
H9J99_RS00570	COG0006	proline dipeptidase activity
H9J99_RS00585	COG2022	thiamine diphosphate biosynthetic process
H9J99_RS00590	COG2104	thiamine diphosphate biosynthetic process
H9J99_RS00595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9J99_RS00605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H9J99_RS00610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9J99_RS00660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9J99_RS00665	COG1739	Uncharacterized protein family UPF0029
H9J99_RS00670	COG1024	Enoyl-CoA hydratase
H9J99_RS00670	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9J99_RS00675	COG0183	Belongs to the thiolase family
H9J99_RS00680	COG0604	alcohol dehydrogenase
H9J99_RS00695	COG0425	Belongs to the sulfur carrier protein TusA family
H9J99_RS00705	COG2119	membrane
H9J99_RS00710	COG0752	glycyl-tRNA synthetase alpha subunit
H9J99_RS00715	COG0751	glycine-tRNA ligase activity
H9J99_RS00720	COG0366	Alpha amylase catalytic
H9J99_RS00725	COG3977	Valine--pyruvate aminotransferase
H9J99_RS00730	COG0071	Belongs to the small heat shock protein (HSP20) family
H9J99_RS00740	COG0187	DNA topoisomerase II activity
H9J99_RS00745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9J99_RS00750	COG0592	DNA-directed DNA polymerase activity
H9J99_RS00755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9J99_RS00770	COG1126	abc transporter atp-binding protein
H9J99_RS00780	COG0594	ribonuclease P activity
H9J99_RS00790	COG0706	membrane insertase activity
H9J99_RS00795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9J99_RS00800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H9J99_RS00805	COG0445	tRNA wobble uridine modification
H9J99_RS00815	COG1192	Involved in chromosome partitioning
H9J99_RS00820	COG1475	DNA binding
H9J99_RS00825	COG3312	ion transport
H9J99_RS00830	COG0356	it plays a direct role in the translocation of protons across the membrane
H9J99_RS00845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9J99_RS00855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9J99_RS00860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9J99_RS00865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9J99_RS00870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9J99_RS00875	COG0765	amino acid transport
H9J99_RS00880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9J99_RS00885	COG2814	Major facilitator Superfamily
H9J99_RS00890	COG0583	DNA-binding transcription factor activity
H9J99_RS00900	COG0129	dihydroxy-acid dehydratase activity
H9J99_RS00905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9J99_RS00910	COG3978	acetolactate synthase activity
H9J99_RS00920	COG0606	chelatase, subunit chli
H9J99_RS00930	COG0204	Acyl-transferase
H9J99_RS00935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9J99_RS00940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H9J99_RS00950	COG3084	Protein conserved in bacteria
H9J99_RS00960	COG4326	sporulation control protein
H9J99_RS00965	COG1272	protein, Hemolysin III
H9J99_RS00975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9J99_RS00980	COG0569	domain protein
H9J99_RS00985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9J99_RS00985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9J99_RS00990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9J99_RS00995	COG0242	peptide deformylase activity
H9J99_RS01005	COG0758	DNA mediated transformation
H9J99_RS01010	COG2922	Belongs to the Smg family
H9J99_RS01015	COG0551	DNA topoisomerase type I activity
H9J99_RS01020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9J99_RS01025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9J99_RS01030	COG0009	L-threonylcarbamoyladenylate synthase
H9J99_RS01035	COG0408	coproporphyrinogen oxidase activity
H9J99_RS01040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9J99_RS01050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H9J99_RS01085	COG0583	DNA-binding transcription factor activity
H9J99_RS01090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9J99_RS01095	COG2960	long-chain fatty acid transporting porin activity
H9J99_RS01100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9J99_RS01105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9J99_RS01155	COG4172	Belongs to the ABC transporter superfamily
H9J99_RS01160	COG0747	negative chemotaxis
H9J99_RS01165	COG0601	transmembrane transport
H9J99_RS01170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9J99_RS01205	COG1609	Transcriptional regulator
H9J99_RS01210	COG0583	DNA-binding transcription factor activity
H9J99_RS01225	COG0129	dihydroxy-acid dehydratase activity
H9J99_RS01230	COG3265	gluconokinase activity
H9J99_RS01235	COG2610	gluconate transmembrane transporter activity
H9J99_RS01240	COG0800	Aldolase
H9J99_RS01245	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H9J99_RS01250	COG0583	DNA-binding transcription factor activity
H9J99_RS01255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9J99_RS01260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H9J99_RS01265	COG0339	signal peptide processing
H9J99_RS01270	COG1522	sequence-specific DNA binding
H9J99_RS01275	COG5002	protein histidine kinase activity
H9J99_RS01275	COG5001	Diguanylate cyclase
H9J99_RS01280	COG0742	ribosomal rna small subunit methyltransferase
H9J99_RS01295	COG0589	response to stress
H9J99_RS01300	COG1528	Iron-storage protein
H9J99_RS01310	COG2081	HI0933 family
H9J99_RS01325	COG2823	Periplasmic or secreted lipoprotein
H9J99_RS01375	COG0628	permease
H9J99_RS01390	COG1322	Protein conserved in bacteria
H9J99_RS01395	COG2226	methyltransferase
H9J99_RS01400	COG3165	ubiquinone biosynthetic process from chorismate
H9J99_RS01405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9J99_RS01410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9J99_RS01415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9J99_RS01420	COG0805	protein transport
H9J99_RS01425	COG0084	hydrolase, TatD family'
H9J99_RS01440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9J99_RS01440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9J99_RS01475	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9J99_RS01485	COG2204	response regulator
H9J99_RS01490	COG3852	Histidine kinase
H9J99_RS01500	COG0174	glutamine synthetase
H9J99_RS01505	COG1217	gtp-binding protein TYPA
H9J99_RS01520	COG1295	ribonuclease BN
H9J99_RS01525	COG1490	D-aminoacyl-tRNA deacylase activity
H9J99_RS01530	COG0456	acetyltransferase
H9J99_RS01540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H9J99_RS01545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9J99_RS01550	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H9J99_RS01555	COG3031	protein transport across the cell outer membrane
H9J99_RS01565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9J99_RS01570	COG1459	type II secretion system
H9J99_RS01575	COG2165	general secretion pathway protein
H9J99_RS01580	COG2165	general secretion pathway protein
H9J99_RS01585	COG2165	general secretion pathway protein
H9J99_RS01590	COG4795	General secretion pathway protein
H9J99_RS01595	COG3156	type II secretion system protein K
H9J99_RS01600	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H9J99_RS01605	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H9J99_RS01615	COG1218	3'(2'),5'-bisphosphate nucleotidase
H9J99_RS01620	COG0494	nUDIX hydrolase
H9J99_RS01625	COG0316	Belongs to the HesB IscA family
H9J99_RS01625	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H9J99_RS01630	COG1040	competence protein
H9J99_RS01635	COG0596	Alpha beta hydrolase
H9J99_RS01645	COG2183	response to ionizing radiation
H9J99_RS01655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9J99_RS01675	COG2233	PERMEase
H9J99_RS01680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9J99_RS01685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9J99_RS01690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9J99_RS01695	COG1758	RNA polymerase activity
H9J99_RS01700	COG0194	GDP metabolic process
H9J99_RS01715	COG0848	biopolymer transport protein
H9J99_RS01720	COG0811	peptide transport
H9J99_RS01740	COG4174	ABC transporter (Permease)
H9J99_RS01745	COG4239	(ABC) transporter, permease
H9J99_RS01750	COG0747	negative chemotaxis
H9J99_RS01755	COG0444	Belongs to the ABC transporter superfamily
H9J99_RS01760	COG4608	Belongs to the ABC transporter superfamily
H9J99_RS01770	COG1561	YicC-like family, N-terminal region
H9J99_RS01775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H9J99_RS01780	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9J99_RS01785	COG1560	Kdo2-lipid A biosynthetic process
H9J99_RS01790	COG1309	transcriptional regulator
H9J99_RS01795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H9J99_RS01805	COG2003	Belongs to the UPF0758 family
H9J99_RS01810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9J99_RS01825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9J99_RS01850	COG0463	Glycosyl transferase, family 2
H9J99_RS01855	COG0859	PFAM glycosyl transferase family 9
H9J99_RS01860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9J99_RS01865	COG3642	lipopolysaccharide core region biosynthetic process
H9J99_RS01885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9J99_RS01910	COG1021	2,3-dihydroxybenzoate-AMP ligase
H9J99_RS01915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9J99_RS01935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9J99_RS01940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H9J99_RS01945	COG2089	acid synthase
H9J99_RS01955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H9J99_RS01960	COG1083	cytidylyl-transferase
H9J99_RS01970	COG1519	Transferase
H9J99_RS01975	COG0859	PFAM glycosyl transferase family 9
H9J99_RS01980	COG1560	Kdo2-lipid A biosynthetic process
H9J99_RS01990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9J99_RS02040	COG1215	transferase activity, transferring glycosyl groups
H9J99_RS02045	COG0438	transferase activity, transferring glycosyl groups
H9J99_RS02095	COG4932	domain protein
H9J99_RS02095	COG5492	domain, Protein
H9J99_RS02130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H9J99_RS02135	COG0149	triose-phosphate isomerase activity
H9J99_RS02160	COG1494	fructose-1,6-bisphosphatase
H9J99_RS02165	COG3074	FtsZ-dependent cytokinesis
H9J99_RS02170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9J99_RS02175	COG1575	Belongs to the MenA family. Type 1 subfamily
H9J99_RS02180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9J99_RS02185	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H9J99_RS02195	COG1609	Transcriptional regulator
H9J99_RS02200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9J99_RS02205	COG0254	rRNA binding
H9J99_RS02215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9J99_RS02220	COG0088	Forms part of the polypeptide exit tunnel
H9J99_RS02230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9J99_RS02235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9J99_RS02240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9J99_RS02245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9J99_RS02255	COG0255	Belongs to the universal ribosomal protein uL29 family
H9J99_RS02260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9J99_RS02265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9J99_RS02270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9J99_RS02275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9J99_RS02280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9J99_RS02285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9J99_RS02290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9J99_RS02305	COG1841	ribosomal large subunit assembly
H9J99_RS02310	COG0200	Binds to the 23S rRNA
H9J99_RS02315	COG0201	protein transport
H9J99_RS02320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9J99_RS02325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9J99_RS02330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9J99_RS02340	COG0202	RNA polymerase activity
H9J99_RS02345	COG0203	ribosomal protein L17
H9J99_RS02355	COG0545	Peptidyl-prolyl cis-trans isomerase
H9J99_RS02365	COG2153	protein acetylation
H9J99_RS02370	COG0513	Belongs to the DEAD box helicase family
H9J99_RS02380	COG0737	Belongs to the 5'-nucleotidase family
H9J99_RS02385	COG1648	precorrin-2 dehydrogenase activity
H9J99_RS02385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9J99_RS02390	COG0175	sulfate reduction
H9J99_RS02395	COG2895	sulfate adenylyltransferase (ATP) activity
H9J99_RS02400	COG3273	potassium ion transport
H9J99_RS02400	COG0471	metal ion transport
H9J99_RS02405	COG0529	Catalyzes the synthesis of activated sulfate
H9J99_RS02425	COG4181	ATPase activity
H9J99_RS02440	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H9J99_RS02450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9J99_RS02455	COG0729	surface antigen
H9J99_RS02460	COG2911	Protein conserved in bacteria
H9J99_RS02465	COG2105	PFAM AIG2 family protein
H9J99_RS02475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9J99_RS02480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H9J99_RS02485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9J99_RS02490	COG0163	prenyltransferase activity
H9J99_RS02495	COG4143	(ABC) transporter
H9J99_RS02505	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H9J99_RS02520	COG2358	TRAP transporter, solute receptor (TAXI family
H9J99_RS02530	COG0039	L-malate dehydrogenase activity
H9J99_RS02540	COG0142	geranyltranstransferase activity
H9J99_RS02545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9J99_RS02555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9J99_RS02560	COG2966	Psort location CytoplasmicMembrane, score
H9J99_RS02575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9J99_RS02580	COG2967	ApaG domain
H9J99_RS02585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9J99_RS02590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9J99_RS02595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9J99_RS02600	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H9J99_RS02605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9J99_RS02615	COG0066	3-isopropylmalate dehydratase activity
H9J99_RS02620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9J99_RS02625	COG0473	3-isopropylmalate dehydrogenase activity
H9J99_RS02630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9J99_RS02650	COG0583	DNA-binding transcription factor activity
H9J99_RS02655	COG1022	Amp-dependent synthetase and ligase
H9J99_RS02660	COG0028	Belongs to the TPP enzyme family
H9J99_RS02665	COG0440	acetolactate synthase activity
H9J99_RS02680	COG0469	pyruvate kinase activity
H9J99_RS02685	COG1349	DNA-binding transcription factor activity
H9J99_RS02690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9J99_RS02735	COG2826	transposase and inactivated derivatives, IS30 family
H9J99_RS02810	COG5002	protein histidine kinase activity
H9J99_RS02820	COG2376	Dihydroxyacetone kinase
H9J99_RS02825	COG1461	Dihydroxyacetone kinase
H9J99_RS02840	COG3722	fumarate hydratase activity
H9J99_RS02845	COG0246	Mannitol dehydrogenase
H9J99_RS02850	COG2213	PTS system mannitol-specific
H9J99_RS02850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9J99_RS02885	COG1464	Belongs to the NlpA lipoprotein family
H9J99_RS02915	COG0840	transmembrane signaling receptor activity
H9J99_RS02950	COG0732	type I restriction modification DNA specificity domain
H9J99_RS03005	COG3550	peptidyl-serine autophosphorylation
H9J99_RS03025	COG0358	DNA primase activity
H9J99_RS03030	COG1610	YqeY-like protein
H9J99_RS03035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9J99_RS03040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9J99_RS03045	COG0596	Alpha beta hydrolase
H9J99_RS03050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9J99_RS03055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9J99_RS03060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9J99_RS03065	COG1968	undecaprenyl-diphosphatase activity
H9J99_RS03075	COG3267	Type II secretory pathway component ExeA
H9J99_RS03075	COG3409	Peptidoglycan-binding domain 1 protein
H9J99_RS03085	COG4991	sh3 domain protein
H9J99_RS03090	COG0306	phosphate transporter
H9J99_RS03095	COG1392	Phosphate transport regulator
H9J99_RS03100	COG3025	triphosphatase activity
H9J99_RS03115	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H9J99_RS03120	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H9J99_RS03120	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H9J99_RS03125	COG1538	Outer membrane efflux protein
H9J99_RS03130	COG0494	nUDIX hydrolase
H9J99_RS03135	COG3151	Protein conserved in bacteria
H9J99_RS03145	COG3150	esterase
H9J99_RS03155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9J99_RS03160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9J99_RS03170	COG3105	Protein conserved in bacteria
H9J99_RS03175	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H9J99_RS03180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9J99_RS03185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9J99_RS03190	COG0723	plastoquinol--plastocyanin reductase activity
H9J99_RS03195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H9J99_RS03200	COG2857	Cytochrome c1
H9J99_RS03205	COG0625	glutathione transferase activity
H9J99_RS03210	COG2969	positive regulation of protein catabolic process
H9J99_RS03215	COG2823	Periplasmic or secreted lipoprotein
H9J99_RS03220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9J99_RS03225	COG0792	nuclease activity
H9J99_RS03235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9J99_RS03245	COG0275	rRNA processing
H9J99_RS03250	COG3116	cell division
H9J99_RS03255	COG0768	penicillin binding
H9J99_RS03260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9J99_RS03265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9J99_RS03270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9J99_RS03275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9J99_RS03280	COG0772	Belongs to the SEDS family
H9J99_RS03285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9J99_RS03290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9J99_RS03295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9J99_RS03300	COG0849	cell division
H9J99_RS03305	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9J99_RS03310	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H9J99_RS03320	COG0653	protein targeting
H9J99_RS03325	COG0494	nUDIX hydrolase
H9J99_RS03330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9J99_RS03335	COG0505	Belongs to the CarA family
H9J99_RS03340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9J99_RS03355	COG0730	response to heat
H9J99_RS03360	COG0583	DNA-binding transcription factor activity
H9J99_RS03365	COG2860	membrane
H9J99_RS03370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9J99_RS03380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9J99_RS03390	COG0493	'glutamate synthase
H9J99_RS03395	COG0067	glutamate synthase
H9J99_RS03395	COG0069	glutamate synthase activity
H9J99_RS03395	COG0070	glutamate synthase
H9J99_RS03405	COG0069	glutamate synthase activity
H9J99_RS03405	COG0067	glutamate synthase
H9J99_RS03405	COG0070	glutamate synthase
H9J99_RS03410	COG1242	4 iron, 4 sulfur cluster binding
H9J99_RS03415	COG5001	Diguanylate cyclase
H9J99_RS03415	COG4251	negative regulation of phosphorylation
H9J99_RS03415	COG3706	GGDEF domain
H9J99_RS03415	COG2203	Gaf domain
H9J99_RS03420	COG2198	Histidine kinase
H9J99_RS03420	COG0784	Response regulator, receiver
H9J99_RS03420	COG5002	protein histidine kinase activity
H9J99_RS03430	COG0745	RESPONSE REGULATOR receiver
H9J99_RS03440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9J99_RS03460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H9J99_RS03465	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H9J99_RS03470	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H9J99_RS03475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9J99_RS03490	COG1115	amino acid carrier protein
H9J99_RS03495	COG3022	response to hydroperoxide
H9J99_RS03500	COG0513	Belongs to the DEAD box helicase family
H9J99_RS03505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9J99_RS03515	COG0716	FMN binding
H9J99_RS03520	COG4974	Belongs to the 'phage' integrase family
H9J99_RS03525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9J99_RS03540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9J99_RS03555	COG0667	Aldo Keto reductase
H9J99_RS03565	COG3066	DNA modification
H9J99_RS03570	COG0494	nUDIX hydrolase
H9J99_RS03580	COG0730	response to heat
H9J99_RS03585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9J99_RS03590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H9J99_RS03600	COG1283	sodium-dependent phosphate transmembrane transporter activity
H9J99_RS03605	COG0583	DNA-binding transcription factor activity
H9J99_RS03610	COG0640	Transcriptional regulator
H9J99_RS03615	COG0268	Binds directly to 16S ribosomal RNA
H9J99_RS03620	COG0728	peptidoglycan biosynthetic process
H9J99_RS03625	COG0196	riboflavin kinase activity
H9J99_RS03630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9J99_RS03635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9J99_RS03640	COG1047	Peptidyl-prolyl cis-trans
H9J99_RS03645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9J99_RS03655	COG3275	phosphorelay sensor kinase activity
H9J99_RS03660	COG1966	Carbon starvation protein
H9J99_RS03675	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9J99_RS03680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H9J99_RS03685	COG1472	Belongs to the glycosyl hydrolase 3 family
H9J99_RS03690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9J99_RS03695	COG0287	Prephenate dehydrogenase
H9J99_RS03695	COG1605	Chorismate mutase
H9J99_RS03700	COG0739	heme binding
H9J99_RS03720	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H9J99_RS03725	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H9J99_RS03730	COG1605	Chorismate mutase
H9J99_RS03730	COG0077	Prephenate dehydratase
H9J99_RS03735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9J99_RS03740	COG0741	lytic transglycosylase activity
H9J99_RS03745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9J99_RS03750	COG0564	pseudouridine synthase activity
H9J99_RS03760	COG0542	response to heat
H9J99_RS03815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9J99_RS03820	COG0826	peptidase U32
H9J99_RS03825	COG2974	May be involved in recombination
H9J99_RS03830	COG0745	RESPONSE REGULATOR receiver
H9J99_RS03835	COG5002	protein histidine kinase activity
H9J99_RS03845	COG0248	Ppx GppA phosphatase
H9J99_RS03850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9J99_RS03860	COG0581	inorganic phosphate transmembrane transporter activity
H9J99_RS03865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9J99_RS03870	COG0704	Plays a role in the regulation of phosphate uptake
H9J99_RS03880	COG3142	Participates in the control of copper homeostasis
H9J99_RS03885	COG0450	alkyl hydroperoxide reductase
H9J99_RS03890	COG0583	DNA-binding transcription factor activity
H9J99_RS03895	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H9J99_RS03905	COG0517	IMP dehydrogenase activity
H9J99_RS03915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9J99_RS03920	COG0343	queuine tRNA-ribosyltransferase activity
H9J99_RS03925	COG1862	Preprotein translocase
H9J99_RS03930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9J99_RS03935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9J99_RS03940	COG0483	inositol monophosphate 1-phosphatase activity
H9J99_RS03955	COG1104	cysteine desulfurase activity
H9J99_RS03960	COG0822	iron-sulfur transferase activity
H9J99_RS03970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9J99_RS03975	COG0443	Heat shock 70 kDa protein
H9J99_RS03980	COG0633	Ferredoxin
H9J99_RS03985	COG2975	iron-sulfur cluster assembly
H9J99_RS03990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9J99_RS03995	COG0105	UTP biosynthetic process
H9J99_RS04000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9J99_RS04010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9J99_RS04015	COG0124	histidyl-tRNA synthetase
H9J99_RS04020	COG2976	Protein conserved in bacteria
H9J99_RS04025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9J99_RS04030	COG1160	GTP binding
H9J99_RS04045	COG1570	exodeoxyribonuclease VII activity
H9J99_RS04050	COG0516	GMP reductase activity
H9J99_RS04050	COG0517	IMP dehydrogenase activity
H9J99_RS04055	COG0519	Catalyzes the synthesis of GMP from XMP
H9J99_RS04055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9J99_RS04060	COG1757	Na H antiporter
H9J99_RS04070	COG1584	GPR1 FUN34 yaaH family protein
H9J99_RS04080	COG1115	amino acid carrier protein
H9J99_RS04110	COG2873	o-acetylhomoserine
H9J99_RS04115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H9J99_RS04135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9J99_RS04135	COG3153	acetyltransferase
H9J99_RS04140	COG0583	DNA-binding transcription factor activity
H9J99_RS04255	COG0582	viral genome integration into host DNA
H9J99_RS04265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9J99_RS04270	COG2867	negative regulation of translational initiation
H9J99_RS04275	COG2914	Belongs to the UPF0125 (RnfH) family
H9J99_RS04280	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9J99_RS04285	COG0497	DNA recombination
H9J99_RS04295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9J99_RS04300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9J99_RS04315	COG0443	Heat shock 70 kDa protein
H9J99_RS04320	COG0484	heat shock protein binding
H9J99_RS04350	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H9J99_RS04360	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H9J99_RS04365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9J99_RS04365	COG0047	phosphoribosylformylglycinamidine synthase activity
H9J99_RS04390	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9J99_RS04395	COG2252	PERMEase
H9J99_RS04400	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H9J99_RS04405	COG1073	alpha beta
H9J99_RS04415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9J99_RS04420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H9J99_RS04425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9J99_RS04430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9J99_RS04430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9J99_RS04450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9J99_RS04455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H9J99_RS04460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H9J99_RS04465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9J99_RS04470	COG0142	geranyltranstransferase activity
H9J99_RS04475	COG1722	exodeoxyribonuclease VII activity
H9J99_RS04480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H9J99_RS04485	COG2885	chlorophyll binding
H9J99_RS04490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9J99_RS04490	COG0301	tRNA thio-modification
H9J99_RS04495	COG0583	DNA-binding transcription factor activity
H9J99_RS04505	COG2363	Small membrane protein
H9J99_RS04510	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H9J99_RS04520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9J99_RS04525	COG1611	Belongs to the LOG family
H9J99_RS04540	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9J99_RS04540	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9J99_RS04550	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H9J99_RS04555	COG1464	Belongs to the NlpA lipoprotein family
H9J99_RS04560	COG2011	ABC-type metal ion transport system permease component
H9J99_RS04565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9J99_RS04570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9J99_RS04580	COG1263	PTS System
H9J99_RS04580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9J99_RS04585	COG0366	Alpha amylase catalytic
H9J99_RS04600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9J99_RS04605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9J99_RS04610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9J99_RS04615	COG0321	lipoyl(octanoyl) transferase activity
H9J99_RS04620	COG2921	Belongs to the UPF0250 family
H9J99_RS04625	COG1686	Belongs to the peptidase S11 family
H9J99_RS04630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9J99_RS04635	COG0772	Belongs to the SEDS family
H9J99_RS04640	COG0768	penicillin binding
H9J99_RS04645	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9J99_RS04650	COG0799	negative regulation of ribosome biogenesis
H9J99_RS04655	COG1466	dna polymerase III delta subunit
H9J99_RS04660	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H9J99_RS04665	COG0495	leucyl-tRNA aminoacylation
H9J99_RS04670	COG2888	peptidyl-tyrosine sulfation
H9J99_RS04675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9J99_RS04680	COG4535	Mg2 and Co2 transporter CorC
H9J99_RS04685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9J99_RS04690	COG1702	phosphate starvation-inducible protein PhoH
H9J99_RS04695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9J99_RS04700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9J99_RS04815	COG0012	GTP binding
H9J99_RS04820	COG0193	aminoacyl-tRNA hydrolase activity
H9J99_RS04825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9J99_RS04830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9J99_RS04835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H9J99_RS04840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9J99_RS04845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9J99_RS04850	COG2890	protein-(glutamine-N5) methyltransferase activity
H9J99_RS04855	COG3094	Invasion gene expression up-regulator, SirB
H9J99_RS04860	COG2912	Transglutaminase-like superfamily
H9J99_RS04865	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H9J99_RS04870	COG0737	Belongs to the 5'-nucleotidase family
H9J99_RS04880	COG1187	pseudouridine synthase activity
H9J99_RS04885	COG2840	Smr protein MutS2
H9J99_RS04920	COG2217	Heavy metal translocating P-type atpase
H9J99_RS04920	COG2608	mercury ion transmembrane transporter activity
H9J99_RS04930	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9J99_RS04935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9J99_RS04985	COG0784	Response regulator, receiver
H9J99_RS04985	COG0835	chemotaxis
H9J99_RS04990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H9J99_RS04995	COG1815	bacterial-type flagellum-dependent cell motility
H9J99_RS05000	COG1558	bacterial-type flagellum-dependent cell motility
H9J99_RS05010	COG1749	Flagellar hook protein flgE
H9J99_RS05015	COG4787	bacterial-type flagellum-dependent cell motility
H9J99_RS05025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H9J99_RS05030	COG1706	bacterial-type flagellum-dependent cell motility
H9J99_RS05035	COG3951	Flagellar rod assembly protein muramidase FlgJ
H9J99_RS05035	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9J99_RS05045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9J99_RS05050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9J99_RS05055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9J99_RS05060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9J99_RS05065	COG2190	(PTS) system
H9J99_RS05070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9J99_RS05075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9J99_RS05080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9J99_RS05085	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H9J99_RS05090	COG3115	cell septum assembly
H9J99_RS05095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9J99_RS05115	COG0330	HflC and HflK could
H9J99_RS05120	COG2194	sulfuric ester hydrolase activity
H9J99_RS05145	COG1215	transferase activity, transferring glycosyl groups
H9J99_RS05150	COG1215	transferase activity, transferring glycosyl groups
H9J99_RS05155	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H9J99_RS05160	COG3118	belongs to the thioredoxin family
H9J99_RS05160	COG0457	Tetratricopeptide repeat
H9J99_RS05165	COG3118	belongs to the thioredoxin family
H9J99_RS05170	COG0300	oxidoreductase activity
H9J99_RS05175	COG1090	epimerase
H9J99_RS05205	COG0622	Phosphoesterase
H9J99_RS05225	COG3710	Transcriptional regulator
H9J99_RS05230	COG0326	Molecular chaperone. Has ATPase activity
H9J99_RS05235	COG0563	adenylate kinase activity
H9J99_RS05240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9J99_RS05245	COG3104	oligopeptide transport
H9J99_RS05250	COG0250	Participates in transcription elongation, termination and antitermination
H9J99_RS05260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9J99_RS05260	COG4651	solute:proton antiporter activity
H9J99_RS05270	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9J99_RS05275	COG1263	PTS System
H9J99_RS05275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9J99_RS05280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9J99_RS05285	COG0735	belongs to the Fur family
H9J99_RS05305	COG0596	Alpha beta hydrolase
H9J99_RS05310	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H9J99_RS05315	COG0033	Phosphoglucomutase
H9J99_RS05340	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H9J99_RS05345	COG1053	succinate dehydrogenase
H9J99_RS05350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9J99_RS05355	COG0567	Dehydrogenase, E1 component
H9J99_RS05360	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9J99_RS05365	COG0045	succinate-CoA ligase (ADP-forming) activity
H9J99_RS05375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9J99_RS05385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H9J99_RS05390	COG4977	sequence-specific DNA binding
H9J99_RS05395	COG1918	ferrous iron import across plasma membrane
H9J99_RS05415	COG0018	arginyl-trna synthetase
H9J99_RS05425	COG0788	formyltetrahydrofolate deformylase activity
H9J99_RS05430	COG1199	ATP-dependent helicase activity
H9J99_RS05435	COG1214	PFAM Peptidase M22, glycoprotease
H9J99_RS05450	COG2267	carboxylic ester hydrolase activity
H9J99_RS05455	COG0318	PFAM AMP-dependent synthetase and ligase
H9J99_RS05460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H9J99_RS05470	COG2894	cell division
H9J99_RS05480	COG3100	YcgL domain-containing protein
H9J99_RS05485	COG2951	lytic endotransglycosylase activity
H9J99_RS05490	COG0583	DNA-binding transcription factor activity
H9J99_RS05495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9J99_RS05500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9J99_RS05510	COG4974	Belongs to the 'phage' integrase family
H9J99_RS05530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9J99_RS05535	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H9J99_RS05540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9J99_RS05545	COG0732	type I restriction modification DNA specificity domain
H9J99_RS05585	COG1028	Short-chain dehydrogenase reductase Sdr
H9J99_RS05595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9J99_RS05620	COG2986	histidine ammonia-lyase
H9J99_RS05625	COG1216	Glycosyl transferase, family 2
H9J99_RS05630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9J99_RS05645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9J99_RS05650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9J99_RS05685	COG1253	flavin adenine dinucleotide binding
H9J99_RS05690	COG0513	Belongs to the DEAD box helicase family
H9J99_RS05695	COG0569	domain protein
H9J99_RS05700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9J99_RS05715	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H9J99_RS05720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9J99_RS05725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9J99_RS05730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H9J99_RS05740	COG2204	response regulator
H9J99_RS05755	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9J99_RS05765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9J99_RS05770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H9J99_RS05775	COG0776	regulation of translation
H9J99_RS05780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9J99_RS05785	COG1555	photosystem II stabilization
H9J99_RS05800	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H9J99_RS05805	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H9J99_RS05810	COG0436	Aminotransferase
H9J99_RS05815	COG1169	isochorismate synthase
H9J99_RS05820	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H9J99_RS05825	COG0596	Alpha beta hydrolase
H9J99_RS05830	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H9J99_RS05850	COG2855	membrane
H9J99_RS05855	COG0477	Major facilitator Superfamily
H9J99_RS05905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9J99_RS05975	COG0753	catalase activity
H9J99_RS05990	COG0783	Belongs to the Dps family
H9J99_RS06010	COG0489	protein tyrosine kinase activity
H9J99_RS06025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9J99_RS06030	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9J99_RS06080	COG0640	Transcriptional regulator
H9J99_RS06105	COG0789	Transcriptional regulator
H9J99_RS06110	COG2801	Transposase and inactivated derivatives
H9J99_RS06155	COG1522	sequence-specific DNA binding
H9J99_RS06165	COG1946	Acyl-CoA thioesterase
H9J99_RS06170	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H9J99_RS06185	COG2199	diguanylate cyclase activity
H9J99_RS06195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9J99_RS06200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H9J99_RS06205	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H9J99_RS06210	COG0516	GMP reductase activity
H9J99_RS06210	COG0517	IMP dehydrogenase activity
H9J99_RS06235	COG0537	adenosine 5'-monophosphoramidase activity
H9J99_RS06260	COG3150	esterase
H9J99_RS06265	COG1252	NADH dehydrogenase
H9J99_RS06280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9J99_RS06290	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9J99_RS06295	COG1136	(ABC) transporter
H9J99_RS06300	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9J99_RS06315	COG1132	(ABC) transporter
H9J99_RS06320	COG1663	tetraacyldisaccharide 4'-kinase activity
H9J99_RS06330	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H9J99_RS06335	COG2719	SpoVR family
H9J99_RS06340	COG2718	Belongs to the UPF0229 family
H9J99_RS06345	COG2766	serine protein kinase
H9J99_RS06350	COG3013	Belongs to the UPF0304 family
H9J99_RS06360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9J99_RS06370	COG1882	Formate acetyltransferase
H9J99_RS06410	COG0708	Exodeoxyribonuclease III
H9J99_RS06420	COG3923	Primosomal replication protein n
H9J99_RS06425	COG0730	response to heat
H9J99_RS06430	COG1199	ATP-dependent helicase activity
H9J99_RS06435	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9J99_RS06440	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9J99_RS06445	COG1187	pseudouridine synthase activity
H9J99_RS06455	COG1278	Cold shock
H9J99_RS06460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9J99_RS06465	COG0542	response to heat
H9J99_RS06475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9J99_RS06480	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H9J99_RS06485	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9J99_RS06495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H9J99_RS06505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9J99_RS06510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9J99_RS06515	COG0297	glycogen (starch) synthase activity
H9J99_RS06535	COG3070	regulator of competence-specific genes
H9J99_RS06540	COG1609	Transcriptional regulator
H9J99_RS06545	COG3381	protein complex oligomerization
H9J99_RS06550	COG0745	RESPONSE REGULATOR receiver
H9J99_RS06555	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H9J99_RS06560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9J99_RS06565	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H9J99_RS06570	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H9J99_RS06575	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H9J99_RS06595	COG0189	ligase activity
H9J99_RS06595	COG4067	protein conserved in archaea
H9J99_RS06600	COG0500	methyltransferase
H9J99_RS06605	COG4106	trans-aconitate 2-methyltransferase activity
H9J99_RS06610	COG1801	Protein of unknown function DUF72
H9J99_RS06615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9J99_RS06620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9J99_RS06625	COG0840	transmembrane signaling receptor activity
H9J99_RS06630	COG0632	four-way junction helicase activity
H9J99_RS06635	COG2255	four-way junction helicase activity
H9J99_RS06640	COG1271	oxidase subunit
H9J99_RS06645	COG1294	oxidase, subunit
H9J99_RS06650	COG4890	Cyd operon protein YbgT
H9J99_RS06660	COG0824	Thioesterase
H9J99_RS06665	COG0811	peptide transport
H9J99_RS06680	COG0823	Involved in the tonB-independent uptake of proteins
H9J99_RS06685	COG2885	chlorophyll binding
H9J99_RS06690	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H9J99_RS06695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9J99_RS06705	COG3766	membrane
H9J99_RS06715	COG0754	glutathionylspermidine amidase activity
H9J99_RS06725	COG0784	Response regulator, receiver
H9J99_RS06725	COG5002	protein histidine kinase activity
H9J99_RS06745	COG0840	transmembrane signaling receptor activity
H9J99_RS06750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9J99_RS06755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9J99_RS06780	COG3568	Endonuclease Exonuclease Phosphatase
H9J99_RS06795	COG0583	DNA-binding transcription factor activity
H9J99_RS06805	COG0686	Belongs to the AlaDH PNT family
H9J99_RS06815	COG1674	ftsk spoiiie
H9J99_RS06820	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H9J99_RS06825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9J99_RS06830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9J99_RS06845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H9J99_RS06850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H9J99_RS06855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9J99_RS06870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H9J99_RS06880	COG0501	Belongs to the peptidase M48B family
H9J99_RS06890	COG0300	oxidoreductase activity
H9J99_RS06905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9J99_RS06925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9J99_RS06930	COG2915	High frequency lysogenization protein hflD homolog
H9J99_RS06935	COG0482	sulfurtransferase activity
H9J99_RS06945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9J99_RS06960	COG1757	Na H antiporter
H9J99_RS06975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9J99_RS06980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H9J99_RS06985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9J99_RS06990	COG0131	Imidazoleglycerol-phosphate dehydratase
H9J99_RS06990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9J99_RS06995	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H9J99_RS07000	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9J99_RS07005	COG0107	imidazoleglycerol-phosphate synthase activity
H9J99_RS07010	COG0140	phosphoribosyl-ATP diphosphatase activity
H9J99_RS07010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9J99_RS07015	COG3012	SEC-C Motif Domain Protein
H9J99_RS07020	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H9J99_RS07025	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9J99_RS07030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9J99_RS07035	COG0215	cysteine-tRNA ligase activity
H9J99_RS07040	COG1435	thymidine kinase activity
H9J99_RS07045	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H9J99_RS07070	COG2116	formate transmembrane transporter activity
H9J99_RS07085	COG0390	transport system, permease component
H9J99_RS07090	COG4459	periplasmic nitrate reductase
H9J99_RS07095	COG3005	denitrification pathway
H9J99_RS07100	COG0243	molybdopterin cofactor binding
H9J99_RS07115	COG1227	inorganic diphosphatase activity
H9J99_RS07125	COG4172	Belongs to the ABC transporter superfamily
H9J99_RS07135	COG4171	peptide transport system, permease
H9J99_RS07150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9J99_RS07155	COG1842	Phage shock protein A
H9J99_RS07165	COG1983	PspC domain protein
H9J99_RS07170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9J99_RS07185	COG2818	Glycosylase
H9J99_RS07190	COG5380	lipid catabolic process
H9J99_RS07195	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H9J99_RS07200	COG0626	cystathionine gamma-synthase activity
H9J99_RS07210	COG0733	neurotransmitter:sodium symporter activity
H9J99_RS07220	COG0564	pseudouridine synthase activity
H9J99_RS07230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9J99_RS07235	COG1151	hydroxylamine reductase activity
H9J99_RS07240	COG3604	Transcriptional regulator
H9J99_RS07250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9J99_RS07255	COG4136	ATPase activity
H9J99_RS07260	COG4135	transport system, permease component
H9J99_RS07265	COG4134	Bacterial extracellular solute-binding protein
H9J99_RS07270	COG0398	Pfam SNARE associated Golgi protein
H9J99_RS07280	COG0493	'glutamate synthase
H9J99_RS07305	COG3313	Fe-S protein
H9J99_RS07315	COG0737	Belongs to the 5'-nucleotidase family
H9J99_RS07330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9J99_RS07350	COG1061	Type III restriction enzyme res subunit
H9J99_RS07355	COG1187	pseudouridine synthase activity
H9J99_RS07360	COG2814	Major facilitator Superfamily
H9J99_RS07390	COG3005	denitrification pathway
H9J99_RS07395	COG0702	epimerase
H9J99_RS07400	COG0534	Mate efflux family protein
H9J99_RS07405	COG4181	ATPase activity
H9J99_RS07420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9J99_RS07435	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9J99_RS07440	COG2985	domain, Protein
H9J99_RS07440	COG3273	potassium ion transport
H9J99_RS07445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9J99_RS07460	COG1737	Transcriptional regulator
H9J99_RS07465	COG0076	glutamate decarboxylase activity
H9J99_RS07475	COG2431	L-lysine efflux transmembrane transporter activity
H9J99_RS07500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9J99_RS07500	COG4191	Histidine kinase
H9J99_RS07510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9J99_RS07515	COG3048	D-serine ammonia-lyase activity
H9J99_RS07520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H9J99_RS07525	COG4988	ABC transporter
H9J99_RS07530	COG0492	ferredoxin-NADP+ reductase activity
H9J99_RS07555	COG0471	metal ion transport
H9J99_RS07560	COG2949	membrane
H9J99_RS07565	COG0281	malic enzyme
H9J99_RS07570	COG1643	Atp-dependent helicase
H9J99_RS07575	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H9J99_RS07590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9J99_RS07625	COG0247	lactate metabolic process
H9J99_RS07625	COG0277	FAD linked oxidase domain protein
H9J99_RS07640	COG2986	histidine ammonia-lyase
H9J99_RS07645	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9J99_RS07655	COG1228	amidohydrolase
H9J99_RS07660	COG2188	Transcriptional regulator
H9J99_RS07675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9J99_RS07685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9J99_RS07695	COG0393	Putative heavy-metal-binding
H9J99_RS07725	COG3706	GGDEF domain
H9J99_RS07730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9J99_RS07735	COG0072	phenylalanine-tRNA ligase activity
H9J99_RS07735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9J99_RS07745	COG0776	regulation of translation
H9J99_RS07755	COG0500	methyltransferase
H9J99_RS07760	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H9J99_RS07765	COG0295	cytidine deaminase activity
H9J99_RS07770	COG1346	cytolysis
H9J99_RS07775	COG1380	Effector of murein hydrolase LrgA
H9J99_RS07780	COG2925	Exonuclease
H9J99_RS07790	COG0702	epimerase
H9J99_RS07800	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H9J99_RS07805	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H9J99_RS07825	COG2988	succinylglutamate desuccinylase activity
H9J99_RS07830	COG4139	cobalamin transport
H9J99_RS07835	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H9J99_RS07855	COG0583	DNA-binding transcription factor activity
H9J99_RS07875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9J99_RS07880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9J99_RS07885	COG3475	LICD family
H9J99_RS07890	COG1451	nucleotide metabolic process
H9J99_RS07895	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H9J99_RS07925	COG3938	Belongs to the proline racemase family
H9J99_RS07940	COG2423	ornithine cyclodeaminase activity
H9J99_RS07945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9J99_RS07950	COG3842	ATPase activity
H9J99_RS07955	COG1176	ABC-type spermidine putrescine transport system, permease component I
H9J99_RS07960	COG1177	transmembrane transport
H9J99_RS07970	COG3291	Pkd domain containing protein
H9J99_RS07990	COG0444	Belongs to the ABC transporter superfamily
H9J99_RS07995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9J99_RS08000	COG0601	transmembrane transport
H9J99_RS08010	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9J99_RS08025	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H9J99_RS08035	COG0625	glutathione transferase activity
H9J99_RS08070	COG2826	transposase and inactivated derivatives, IS30 family
H9J99_RS08085	COG1278	Cold shock
H9J99_RS08100	COG0557	exoribonuclease II activity
H9J99_RS08135	COG0471	metal ion transport
H9J99_RS08140	COG4191	Histidine kinase
H9J99_RS08140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9J99_RS08150	COG3300	MHYT domain
H9J99_RS08150	COG5001	Diguanylate cyclase
H9J99_RS08160	COG1280	lysine exporter protein (LysE YggA)
H9J99_RS08165	COG1328	CTP reductase activity
H9J99_RS08170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9J99_RS08180	COG0861	Integral membrane protein TerC family
H9J99_RS08190	COG1368	sulfuric ester hydrolase activity
H9J99_RS08195	COG0642	Histidine kinase
H9J99_RS08200	COG0745	RESPONSE REGULATOR receiver
H9J99_RS08210	COG1028	Short-chain dehydrogenase reductase Sdr
H9J99_RS08230	COG2113	Glycine betaine
H9J99_RS08235	COG4176	ABC-type proline glycine betaine transport system permease component
H9J99_RS08255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9J99_RS08260	COG0456	acetyltransferase
H9J99_RS08265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H9J99_RS08270	COG0662	Cupin 2, conserved barrel domain protein
H9J99_RS08275	COG0527	aspartate kinase activity
H9J99_RS08300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9J99_RS08315	COG3290	protein histidine kinase activity
H9J99_RS08320	COG4565	transcriptional regulatory protein
H9J99_RS08325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9J99_RS08330	COG0363	glucosamine-6-phosphate deaminase activity
H9J99_RS08335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H9J99_RS08350	COG3284	Transcriptional regulator
H9J99_RS08355	COG1012	belongs to the aldehyde dehydrogenase family
H9J99_RS08425	COG4669	(LipO)protein
H9J99_RS08445	COG3177	Filamentation induced by cAMP protein fic
H9J99_RS08470	COG4792	protein secretion
H9J99_RS08475	COG4791	protein targeting
H9J99_RS08480	COG4794	Type iii secretion
H9J99_RS08485	COG4790	Type iii secretion
H9J99_RS08555	COG0457	Tetratricopeptide repeat
H9J99_RS08575	COG0730	response to heat
H9J99_RS08605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H9J99_RS08610	COG0372	Belongs to the citrate synthase family
H9J99_RS08620	COG2828	Protein conserved in bacteria
H9J99_RS08645	COG0561	phosphatase activity
H9J99_RS08650	COG0602	queuosine metabolic process
H9J99_RS08655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H9J99_RS08660	COG3706	GGDEF domain
H9J99_RS08700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9J99_RS08705	COG0840	transmembrane signaling receptor activity
H9J99_RS08710	COG1254	Belongs to the acylphosphatase family
H9J99_RS08715	COG2920	part of a sulfur-relay system
H9J99_RS08725	COG0670	Belongs to the BI1 family
H9J99_RS08730	COG1126	abc transporter atp-binding protein
H9J99_RS08735	COG0765	amino acid transport
H9J99_RS08740	COG4597	amino acid ABC transporter
H9J99_RS08745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9J99_RS08755	COG1666	GTP binding
H9J99_RS08760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9J99_RS08780	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H9J99_RS08780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9J99_RS08790	COG2995	paraquat-inducible protein a
H9J99_RS08795	COG1132	(ABC) transporter
H9J99_RS08800	COG1956	GAF domain-containing protein
H9J99_RS08805	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H9J99_RS08820	COG0308	aminopeptidase N
H9J99_RS08835	COG0167	dihydroorotate dehydrogenase activity
H9J99_RS08845	COG0116	Belongs to the methyltransferase superfamily
H9J99_RS08845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9J99_RS08855	COG0488	(ABC) transporter
H9J99_RS08870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9J99_RS08875	COG1067	ATP-dependent peptidase activity
H9J99_RS08880	COG3120	sequence-specific DNA binding
H9J99_RS08900	COG0784	Response regulator, receiver
H9J99_RS08900	COG2205	protein histidine kinase activity
H9J99_RS08915	COG3278	Belongs to the heme-copper respiratory oxidase family
H9J99_RS08930	COG2010	Cytochrome c
H9J99_RS08940	COG2217	Heavy metal translocating P-type atpase
H9J99_RS08955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9J99_RS08960	COG0589	response to stress
H9J99_RS08965	COG0037	tRNA processing
H9J99_RS08985	COG3842	ATPase activity
H9J99_RS08995	COG1177	transmembrane transport
H9J99_RS09005	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H9J99_RS09010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9J99_RS09020	COG0004	ammonium transporteR
H9J99_RS09075	COG0437	4 iron, 4 sulfur cluster binding
H9J99_RS09080	COG0243	molybdopterin cofactor binding
H9J99_RS09080	COG3383	formate dehydrogenase (NAD+) activity
H9J99_RS09090	COG3381	protein complex oligomerization
H9J99_RS09110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H9J99_RS09115	COG0488	(ABC) transporter
H9J99_RS09125	COG2204	response regulator
H9J99_RS09140	COG3842	ATPase activity
H9J99_RS09145	COG0746	molybdenum cofactor guanylyltransferase activity
H9J99_RS09160	COG1940	carbohydrate kinase activity
H9J99_RS09165	COG3148	PFAM DTW domain containing protein
H9J99_RS09200	COG3290	protein histidine kinase activity
H9J99_RS09200	COG0840	transmembrane signaling receptor activity
H9J99_RS09205	COG0791	NLP P60 protein
H9J99_RS09215	COG3706	GGDEF domain
H9J99_RS09220	COG2201	protein-glutamate methylesterase activity
H9J99_RS09225	COG3001	Fructosamine kinase
H9J99_RS09235	COG0307	riboflavin synthase, alpha
H9J99_RS09240	COG0534	Mate efflux family protein
H9J99_RS09250	COG1793	dna ligase
H9J99_RS09280	COG2204	response regulator
H9J99_RS09290	COG0438	transferase activity, transferring glycosyl groups
H9J99_RS09320	COG0438	transferase activity, transferring glycosyl groups
H9J99_RS09325	COG1215	transferase activity, transferring glycosyl groups
H9J99_RS09330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9J99_RS09340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9J99_RS09355	COG1643	Atp-dependent helicase
H9J99_RS09360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9J99_RS09375	COG3302	dmso reductase anchor subunit
H9J99_RS09380	COG0437	4 iron, 4 sulfur cluster binding
H9J99_RS09385	COG0243	molybdopterin cofactor binding
H9J99_RS09415	COG3706	GGDEF domain
H9J99_RS09425	COG0443	Heat shock 70 kDa protein
H9J99_RS09430	COG0443	Heat shock 70 kDa protein
H9J99_RS09455	COG1132	(ABC) transporter
H9J99_RS09460	COG1132	(ABC) transporter
H9J99_RS09480	COG0814	amino acid
H9J99_RS09490	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H9J99_RS09515	COG1115	amino acid carrier protein
H9J99_RS09525	COG1280	lysine exporter protein (LysE YggA)
H9J99_RS09530	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H9J99_RS09535	COG1560	Kdo2-lipid A biosynthetic process
H9J99_RS09540	COG0531	amino acid
H9J99_RS09550	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H9J99_RS09555	COG3063	Type IV pilus biogenesis stability protein PilW
H9J99_RS09585	COG0110	maltose O-acetyltransferase activity
H9J99_RS09605	COG2315	Protein conserved in bacteria
H9J99_RS09610	COG1846	Transcriptional regulator
H9J99_RS09640	COG2771	luxR family
H9J99_RS09640	COG2200	EAL domain
H9J99_RS09645	COG1227	inorganic diphosphatase activity
H9J99_RS09650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H9J99_RS09655	COG1012	belongs to the aldehyde dehydrogenase family
H9J99_RS09660	COG2957	Belongs to the agmatine deiminase family
H9J99_RS09670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9J99_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
H9J99_RS09680	COG1396	sequence-specific DNA binding
H9J99_RS09680	COG1917	Cupin 2, conserved barrel domain protein
H9J99_RS09685	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H9J99_RS09690	COG0174	glutamine synthetase
H9J99_RS09695	COG1757	Na H antiporter
H9J99_RS09725	COG0583	DNA-binding transcription factor activity
H9J99_RS09740	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H9J99_RS09750	COG2985	domain, Protein
H9J99_RS09775	COG2272	Belongs to the type-B carboxylesterase lipase family
H9J99_RS09780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9J99_RS09785	COG0729	surface antigen
H9J99_RS09845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9J99_RS09850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9J99_RS09895	COG0582	viral genome integration into host DNA
H9J99_RS09910	COG0456	acetyltransferase
H9J99_RS10090	COG1484	DNA-dependent DNA replication
H9J99_RS10095	COG4584	PFAM Integrase catalytic
H9J99_RS10130	COG3153	acetyltransferase
H9J99_RS10385	COG1280	lysine exporter protein (LysE YggA)
H9J99_RS10495	COG0840	transmembrane signaling receptor activity
H9J99_RS10500	COG4580	involved in the transport of maltose and maltodextrins
H9J99_RS10505	COG1874	Beta-galactosidase
H9J99_RS10515	COG3833	ABC-type maltose transport systems, permease component
H9J99_RS10520	COG1175	transmembrane transport
H9J99_RS10525	COG2182	Extracellular solute-binding protein
H9J99_RS10535	COG1609	Transcriptional regulator
H9J99_RS10550	COG3547	Transposase (IS116 IS110 IS902 family)
H9J99_RS10555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9J99_RS10570	COG2211	Major facilitator Superfamily
H9J99_RS10580	COG4580	involved in the transport of maltose and maltodextrins
H9J99_RS10590	COG3250	beta-galactosidase activity
H9J99_RS10595	COG1609	Transcriptional regulator
H9J99_RS10620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9J99_RS10695	COG0456	acetyltransferase
H9J99_RS10905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9J99_RS10915	COG3768	UPF0283 membrane protein
H9J99_RS10920	COG3106	COG3106 Predicted ATPase
H9J99_RS10935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9J99_RS10950	COG0494	nUDIX hydrolase
H9J99_RS10955	COG0814	amino acid
H9J99_RS10960	COG1760	l-serine dehydratase
H9J99_RS10965	COG2200	EAL domain
H9J99_RS10975	COG0720	synthase
H9J99_RS10980	COG0840	transmembrane signaling receptor activity
H9J99_RS10985	COG0017	Asparaginyl-tRNA synthetase
H9J99_RS10995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9J99_RS11010	COG1448	Aminotransferase
H9J99_RS11030	COG0840	transmembrane signaling receptor activity
H9J99_RS11035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9J99_RS11040	COG1846	Transcriptional regulator
H9J99_RS11065	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H9J99_RS11080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9J99_RS11085	COG3108	Peptidase M15
H9J99_RS11090	COG2989	Protein conserved in bacteria
H9J99_RS11115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9J99_RS11125	COG3088	subunit of a heme lyase
H9J99_RS11125	COG4235	cytochrome complex assembly
H9J99_RS11135	COG1138	Cytochrome C-type biogenesis protein
H9J99_RS11140	COG3301	Polysulphide reductase, NrfD
H9J99_RS11145	COG0437	4 iron, 4 sulfur cluster binding
H9J99_RS11155	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H9J99_RS11175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9J99_RS11180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9J99_RS11185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9J99_RS11210	COG0019	diaminopimelate decarboxylase activity
H9J99_RS11255	COG2197	response regulator
H9J99_RS11260	COG0417	DNA replication proofreading
H9J99_RS11270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9J99_RS11275	COG3099	Belongs to the UPF0263 family
H9J99_RS11280	COG1187	pseudouridine synthase activity
H9J99_RS11290	COG0009	L-threonylcarbamoyladenylate synthase
H9J99_RS11295	COG0613	PHP domain protein
H9J99_RS11305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9J99_RS11310	COG0512	Glutamine amidotransferase of anthranilate synthase
H9J99_RS11315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9J99_RS11320	COG0135	phosphoribosylanthranilate isomerase activity
H9J99_RS11320	COG0134	indole-3-glycerol-phosphate synthase activity
H9J99_RS11325	COG0133	tryptophan synthase activity
H9J99_RS11330	COG0159	tryptophan synthase activity
H9J99_RS11335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9J99_RS11340	COG0318	PFAM AMP-dependent synthetase and ligase
H9J99_RS11345	COG1301	dicarboxylic acid transport
H9J99_RS11365	COG2917	probably involved in intracellular septation
H9J99_RS11375	COG2350	Protein conserved in bacteria
H9J99_RS11385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H9J99_RS11390	COG0583	DNA-binding transcription factor activity
H9J99_RS11405	COG2203	Gaf domain
H9J99_RS11405	COG3706	GGDEF domain
H9J99_RS11405	COG4251	negative regulation of phosphorylation
H9J99_RS11405	COG5001	Diguanylate cyclase
H9J99_RS11410	COG1032	radical SAM domain protein
H9J99_RS11415	COG0840	transmembrane signaling receptor activity
H9J99_RS11420	COG0745	RESPONSE REGULATOR receiver
H9J99_RS11425	COG3850	Histidine kinase
H9J99_RS11425	COG5002	protein histidine kinase activity
H9J99_RS11475	COG1335	isochorismatase
H9J99_RS11480	COG1136	(ABC) transporter
H9J99_RS11480	COG0577	efflux transmembrane transporter activity
H9J99_RS11485	COG1136	(ABC) transporter
H9J99_RS11485	COG0577	efflux transmembrane transporter activity
H9J99_RS11500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9J99_RS11520	COG3118	belongs to the thioredoxin family
H9J99_RS11525	COG4232	protein-disulfide reductase activity
H9J99_RS11565	COG2863	cytochrome
H9J99_RS11570	COG3258	Cytochrome c
H9J99_RS11575	COG2995	paraquat-inducible protein a
H9J99_RS11580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9J99_RS11580	COG3008	intermembrane lipid transfer
H9J99_RS11590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H9J99_RS11600	COG0463	Glycosyl transferase, family 2
H9J99_RS11615	COG4166	transmembrane transport
H9J99_RS11620	COG0284	orotidine-5'-phosphate decarboxylase activity
H9J99_RS11625	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H9J99_RS11630	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H9J99_RS11640	COG0539	negative regulation of cytoplasmic translation
H9J99_RS11645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9J99_RS11650	COG0616	signal peptide processing
H9J99_RS11655	COG1028	Short-chain dehydrogenase reductase Sdr
H9J99_RS11670	COG0587	DNA-directed DNA polymerase activity
H9J99_RS11675	COG0835	chemotaxis
H9J99_RS11675	COG0784	Response regulator, receiver
H9J99_RS11680	COG1940	carbohydrate kinase activity
H9J99_RS11685	COG0469	pyruvate kinase activity
H9J99_RS11690	COG4667	esterase of the alpha-beta hydrolase superfamily
H9J99_RS11705	COG0733	neurotransmitter:sodium symporter activity
H9J99_RS11720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9J99_RS11720	COG1263	PTS System
H9J99_RS11725	COG0084	hydrolase, TatD family'
H9J99_RS11735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9J99_RS11740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9J99_RS11770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9J99_RS11775	COG0416	fatty acid biosynthetic process
H9J99_RS11785	COG1399	metal-binding, possibly nucleic acid-binding protein
H9J99_RS11790	COG0424	maF-like protein
H9J99_RS11795	COG0564	pseudouridine synthase activity
H9J99_RS11800	COG1530	ribonuclease E activity
H9J99_RS11805	COG0659	secondary active sulfate transmembrane transporter activity
H9J99_RS11810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9J99_RS11815	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H9J99_RS11825	COG0572	uridine kinase
H9J99_RS11830	COG0489	protein tyrosine kinase activity
H9J99_RS11835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9J99_RS11835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9J99_RS11845	COG2186	Transcriptional regulator
H9J99_RS11850	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9J99_RS11855	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H9J99_RS11860	COG3318	Belongs to the UPF0149 family
H9J99_RS11860	COG3012	SEC-C Motif Domain Protein
H9J99_RS11865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9J99_RS11885	COG4120	Belongs to the binding-protein-dependent transport system permease family
H9J99_RS11895	COG3092	negative regulation of chromosome organization
H9J99_RS11900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9J99_RS11905	COG0280	phosphate acetyltransferase
H9J99_RS11905	COG0857	belongs to the CobB CobQ family
H9J99_RS11910	COG3174	membrane
H9J99_RS11920	COG0435	Glutathione S-transferase
H9J99_RS11930	COG0444	Belongs to the ABC transporter superfamily
H9J99_RS11935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9J99_RS11940	COG0601	transmembrane transport
H9J99_RS11950	COG0314	molybdopterin synthase activity
H9J99_RS11955	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H9J99_RS11960	COG0315	cyclic pyranopterin monophosphate synthase activity
H9J99_RS11965	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9J99_RS11970	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9J99_RS11975	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H9J99_RS11980	COG2198	Histidine kinase
H9J99_RS11985	COG2204	response regulator
H9J99_RS11990	COG0556	nucleotide-excision repair
H9J99_RS12000	COG4657	Part of a membrane complex involved in electron transport
H9J99_RS12005	COG2878	Part of a membrane complex involved in electron transport
H9J99_RS12010	COG4656	Part of a membrane complex involved in electron transport
H9J99_RS12015	COG4658	electron transport chain
H9J99_RS12020	COG4659	FMN binding
H9J99_RS12025	COG4660	Part of a membrane complex involved in electron transport
H9J99_RS12030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9J99_RS12035	COG0346	lactoylglutathione lyase activity
H9J99_RS12045	COG2885	chlorophyll binding
H9J99_RS12050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9J99_RS12055	COG2056	Na+-H+ antiporter family
H9J99_RS12065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H9J99_RS12085	COG1012	belongs to the aldehyde dehydrogenase family
H9J99_RS12085	COG1454	alcohol dehydrogenase
H9J99_RS12090	COG2095	MarC family integral membrane protein
H9J99_RS12095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9J99_RS12100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9J99_RS12105	COG1757	Na H antiporter
H9J99_RS12120	COG3081	Nucleoid-associated protein
H9J99_RS12125	COG3082	Protein of unknown function (DUF1414)
H9J99_RS12130	COG3083	sulfuric ester hydrolase activity
H9J99_RS12140	COG0123	including yeast histone deacetylase and acetoin utilization protein
H9J99_RS12155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9J99_RS12165	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9J99_RS12165	COG1902	pentaerythritol trinitrate reductase activity
H9J99_RS12170	COG0616	signal peptide processing
H9J99_RS12175	COG0252	asparaginase activity
H9J99_RS12180	COG3139	Protein of unknown function (DUF1315)
H9J99_RS12190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9J99_RS12195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9J99_RS12200	COG0676	glucose-6-phosphate 1-epimerase activity
H9J99_RS12210	COG2226	methyltransferase
H9J99_RS12225	COG1785	Belongs to the alkaline phosphatase family
H9J99_RS12235	COG0346	lactoylglutathione lyase activity
H9J99_RS12240	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H9J99_RS12245	COG0668	transmembrane transport
H9J99_RS12250	COG2983	Belongs to the UPF0260 family
H9J99_RS12255	COG2261	transglycosylase associated protein
H9J99_RS12270	COG3681	Belongs to the UPF0597 family
H9J99_RS12275	COG0251	oxidation-reduction process
H9J99_RS12280	COG0814	amino acid
H9J99_RS12285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9J99_RS12290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9J99_RS12295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9J99_RS12305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9J99_RS12310	COG2832	Protein of unknown function (DUF454)
H9J99_RS12315	COG0745	RESPONSE REGULATOR receiver
H9J99_RS12320	COG0583	DNA-binding transcription factor activity
H9J99_RS12325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H9J99_RS12330	COG1286	toxin biosynthetic process
H9J99_RS12335	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H9J99_RS12340	COG0285	dihydrofolate synthase activity
H9J99_RS12345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9J99_RS12350	COG0101	tRNA pseudouridine synthase activity
H9J99_RS12360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9J99_RS12365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9J99_RS12370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9J99_RS12380	COG0431	NADPH-dependent FMN reductase
H9J99_RS12390	COG3101	peptidyl-lysine hydroxylation
H9J99_RS12395	COG2860	membrane
H9J99_RS12400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9J99_RS12405	COG2890	protein-(glutamine-N5) methyltransferase activity
H9J99_RS12410	COG2840	Smr protein MutS2
H9J99_RS12415	COG2062	phosphohistidine phosphatase, SixA
H9J99_RS12430	COG1024	Enoyl-CoA hydratase
H9J99_RS12430	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9J99_RS12435	COG0183	Belongs to the thiolase family
H9J99_RS12450	COG2067	long-chain fatty acid transport protein
H9J99_RS12465	COG2853	Lipoprotein
H9J99_RS12480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9J99_RS12485	COG1138	Cytochrome C-type biogenesis protein
H9J99_RS12490	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H9J99_RS12495	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9J99_RS12500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9J99_RS12505	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9J99_RS12510	COG4133	protoheme IX ABC transporter activity
H9J99_RS12520	COG0835	chemotaxis
H9J99_RS12530	COG1192	Involved in chromosome partitioning
H9J99_RS12535	COG2201	protein-glutamate methylesterase activity
H9J99_RS12540	COG0784	Response regulator, receiver
H9J99_RS12540	COG2198	Histidine kinase
H9J99_RS12540	COG0643	Histidine kinase
H9J99_RS12545	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H9J99_RS12595	COG0596	Alpha beta hydrolase
H9J99_RS12635	COG1278	Cold shock
H9J99_RS12645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H9J99_RS12660	COG2826	transposase and inactivated derivatives, IS30 family
H9J99_RS12670	COG0583	DNA-binding transcription factor activity
H9J99_RS12720	COG1684	flagellar biosynthetic protein fliR
H9J99_RS12725	COG1987	bacterial-type flagellum assembly
H9J99_RS12775	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H9J99_RS12785	COG1677	Flagellar hook-basal body complex protein FliE
H9J99_RS12805	COG1516	flagellar protein fliS
H9J99_RS12815	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H9J99_RS12820	COG1334	flagellar protein FlaG
H9J99_RS12825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9J99_RS12830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9J99_RS12835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9J99_RS12840	COG2837	iron assimilation
H9J99_RS12865	COG1393	Belongs to the ArsC family
H9J99_RS12870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9J99_RS12885	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H9J99_RS12890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9J99_RS12895	COG2716	regulation of RNA biosynthetic process
H9J99_RS12900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9J99_RS12915	COG4783	chaperone-mediated protein folding
H9J99_RS12920	COG1393	Belongs to the ArsC family
H9J99_RS12940	COG2233	PERMEase
H9J99_RS12945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9J99_RS12950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9J99_RS12955	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9J99_RS12960	COG0121	glutamine amidotransferase
H9J99_RS12965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9J99_RS12970	COG1960	acyl-CoA dehydrogenase activity
H9J99_RS12985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9J99_RS12990	COG0328	RNA-DNA hybrid ribonuclease activity
H9J99_RS12995	COG2226	methyltransferase
H9J99_RS13000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9J99_RS13005	COG0741	lytic transglycosylase activity
H9J99_RS13005	COG1388	LysM domain
H9J99_RS13015	COG3021	interspecies interaction between organisms
H9J99_RS13020	COG0347	Belongs to the P(II) protein family
H9J99_RS13030	COG0037	tRNA processing
H9J99_RS13035	COG0825	malonyl-CoA metabolic process
H9J99_RS13040	COG0587	DNA-directed DNA polymerase activity
H9J99_RS13045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9J99_RS13050	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9J99_RS13055	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9J99_RS13060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9J99_RS13065	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9J99_RS13070	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H9J99_RS13080	COG0750	zinc metalloprotease
H9J99_RS13085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9J99_RS13090	COG0575	Belongs to the CDS family
H9J99_RS13095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9J99_RS13100	COG0233	cytoplasmic translational termination
H9J99_RS13110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9J99_RS13115	COG0052	Belongs to the universal ribosomal protein uS2 family
H9J99_RS13120	COG0024	Methionine aminopeptidase
H9J99_RS13125	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H9J99_RS13135	COG0564	pseudouridine synthase activity
H9J99_RS13140	COG3098	single-species biofilm formation
H9J99_RS13165	COG1671	Belongs to the UPF0178 family
H9J99_RS13170	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H9J99_RS13180	COG0254	rRNA binding
H9J99_RS13185	COG1720	tRNA m6t6A37 methyltransferase activity
H9J99_RS13190	COG0442	prolyl-tRNA aminoacylation
H9J99_RS13210	COG0733	neurotransmitter:sodium symporter activity
H9J99_RS13225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9J99_RS13230	COG0514	ATP-dependent DNA helicase (RecQ)
H9J99_RS13235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9J99_RS13250	COG1477	protein flavinylation
H9J99_RS13255	COG2871	sodium ion transport
H9J99_RS13260	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9J99_RS13265	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9J99_RS13270	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9J99_RS13275	COG1805	sodium ion transport
H9J99_RS13280	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9J99_RS13285	COG0271	Belongs to the BolA IbaG family
H9J99_RS13290	COG2813	Specifically methylates the guanine in position
H9J99_RS13295	COG3056	Lipoprotein
H9J99_RS13315	COG1595	DNA-templated transcription, initiation
H9J99_RS13330	COG3248	Nucleoside-binding outer membrane protein
H9J99_RS13335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9J99_RS13340	COG0693	protein deglycase activity
H9J99_RS13345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9J99_RS13350	COG3706	GGDEF domain
H9J99_RS13355	COG2166	iron-sulfur cluster assembly
H9J99_RS13360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9J99_RS13365	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H9J99_RS13375	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9J99_RS13375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9J99_RS13400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9J99_RS13405	COG1074	ATP-dependent DNA helicase activity
H9J99_RS13410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H9J99_RS13430	COG3141	response to X-ray
H9J99_RS13435	COG2171	N-acyltransferase activity
H9J99_RS13440	COG0584	glycerophosphoryl diester phosphodiesterase
H9J99_RS13445	COG2271	Major facilitator Superfamily
H9J99_RS13450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9J99_RS13455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9J99_RS13460	COG1349	DNA-binding transcription factor activity
H9J99_RS13465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9J99_RS13470	COG0598	Magnesium transport protein CorA
H9J99_RS13490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9J99_RS13495	COG1609	Transcriptional regulator
H9J99_RS13515	COG2017	converts alpha-aldose to the beta-anomer
H9J99_RS13520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9J99_RS13530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9J99_RS13535	COG1609	Transcriptional regulator
H9J99_RS13540	COG3250	beta-galactosidase activity
H9J99_RS13545	COG2731	YhcH YjgK YiaL family protein
H9J99_RS13550	COG0531	amino acid
H9J99_RS13555	COG0583	DNA-binding transcription factor activity
H9J99_RS13615	COG4964	Belongs to the GSP D family
H9J99_RS13640	COG2169	Transcriptional regulator
H9J99_RS13645	COG1022	Amp-dependent synthetase and ligase
H9J99_RS13655	COG0583	DNA-binding transcription factor activity
H9J99_RS13660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9J99_RS13665	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H9J99_RS13675	COG0560	Phosphoserine phosphatase
H9J99_RS13685	COG0813	purine-nucleoside phosphorylase activity
H9J99_RS13690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H9J99_RS13695	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H9J99_RS13700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H9J99_RS13705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9J99_RS13710	COG0084	hydrolase, TatD family'
H9J99_RS13720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9J99_RS13740	COG3153	acetyltransferase
H9J99_RS13745	COG3154	lipid carrier protein
H9J99_RS13755	COG0826	peptidase U32
H9J99_RS13760	COG0826	peptidase U32
H9J99_RS13765	COG0534	Mate efflux family protein
H9J99_RS13780	COG1185	polyribonucleotide nucleotidyltransferase activity
H9J99_RS13785	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9J99_RS13790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9J99_RS13795	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9J99_RS13800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9J99_RS13805	COG0195	Participates in both transcription termination and antitermination
H9J99_RS13810	COG0779	Required for maturation of 30S ribosomal subunits
H9J99_RS13825	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9J99_RS13830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9J99_RS13835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9J99_RS13840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9J99_RS13845	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H9J99_RS13850	COG1534	Rna-binding protein
H9J99_RS13855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9J99_RS13860	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9J99_RS13865	COG2027	D-alanyl-D-alanine carboxypeptidase
H9J99_RS13875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9J99_RS13880	COG0739	heme binding
H9J99_RS13885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9J99_RS13895	COG0316	Belongs to the HesB IscA family
H9J99_RS13900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9J99_RS13910	COG0628	permease
H9J99_RS13915	COG2813	Specifically methylates the guanine in position
H9J99_RS13920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9J99_RS13920	COG0784	Response regulator, receiver
H9J99_RS13920	COG2205	protein histidine kinase activity
H9J99_RS13920	COG2198	Histidine kinase
H9J99_RS13925	COG0747	negative chemotaxis
H9J99_RS13935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9J99_RS13940	COG0444	Belongs to the ABC transporter superfamily
H9J99_RS13945	COG4608	Belongs to the ABC transporter superfamily
H9J99_RS13955	COG2971	BadF BadG BcrA BcrD
H9J99_RS13970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9J99_RS13975	COG3842	ATPase activity
H9J99_RS13985	COG1840	ABC-type Fe3 transport system, periplasmic component
H9J99_RS13990	COG0004	ammonium transporteR
H9J99_RS14000	COG3112	Uncharacterised protein family (UPF0231)
H9J99_RS14005	COG1049	propionate catabolic process, 2-methylcitrate cycle
H9J99_RS14010	COG1752	Esterase of the alpha-beta hydrolase superfamily
H9J99_RS14015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9J99_RS14065	COG1643	Atp-dependent helicase
H9J99_RS14070	COG1489	DNA binding
H9J99_RS14080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9J99_RS14090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9J99_RS14095	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9J99_RS14100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9J99_RS14105	COG1560	Kdo2-lipid A biosynthetic process
H9J99_RS14110	COG0842	Transport permease protein
H9J99_RS14115	COG1131	(ABC) transporter
H9J99_RS14120	COG0659	secondary active sulfate transmembrane transporter activity
H9J99_RS14125	COG0288	reversible hydration of carbon dioxide
H9J99_RS14140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9J99_RS14145	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9J99_RS14150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9J99_RS14155	COG2186	Transcriptional regulator
H9J99_RS14165	COG0157	Belongs to the NadC ModD family
H9J99_RS14175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9J99_RS14180	COG1459	type II secretion system
H9J99_RS14190	COG0237	dephospho-CoA kinase activity
H9J99_RS14195	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H9J99_RS14200	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H9J99_RS14205	COG0335	large ribosomal subunit rRNA binding
H9J99_RS14210	COG0336	Belongs to the RNA methyltransferase TrmD family
H9J99_RS14215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9J99_RS14220	COG0228	four-way junction DNA binding
H9J99_RS14225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9J99_RS14230	COG4137	Cytochrome C assembly protein
H9J99_RS14235	COG4536	flavin adenine dinucleotide binding
H9J99_RS14240	COG1854	S-ribosylhomocysteine lyase activity
H9J99_RS14250	COG2918	glutathione biosynthetic process
H9J99_RS14255	COG0612	Peptidase, M16
H9J99_RS14260	COG1238	metal cluster binding
H9J99_RS14275	COG0511	ligase activity, forming carbon-carbon bonds
H9J99_RS14275	COG5016	pyruvate
H9J99_RS14280	COG3630	sodium ion export across plasma membrane
H9J99_RS14340	COG0527	aspartate kinase activity
H9J99_RS14345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9J99_RS14350	COG2137	regulation of response to DNA damage stimulus
H9J99_RS14355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9J99_RS14360	COG1546	Belongs to the CinA family
H9J99_RS14365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9J99_RS14370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9J99_RS14380	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9J99_RS14385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9J99_RS14390	COG0585	pseudouridine synthase activity
H9J99_RS14395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9J99_RS14400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9J99_RS14405	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H9J99_RS14410	COG0148	phosphopyruvate hydratase activity
H9J99_RS14415	COG0504	CTP synthase activity
H9J99_RS14420	COG3956	TIGRFAM MazG family protein
H9J99_RS14425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9J99_RS14430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9J99_RS14440	COG0736	holo-[acyl-carrier-protein] synthase activity
H9J99_RS14445	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H9J99_RS14450	COG1381	Involved in DNA repair and RecF pathway recombination
H9J99_RS14455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9J99_RS14460	COG0571	ribonuclease III activity
H9J99_RS14470	COG0481	GTPase activity
H9J99_RS14475	COG3086	response to oxidative stress
H9J99_RS14485	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H9J99_RS14490	COG1595	DNA-templated transcription, initiation
H9J99_RS14495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H9J99_RS14500	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H9J99_RS14505	COG0354	folic acid binding
H9J99_RS14520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9J99_RS14525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9J99_RS14530	COG3079	Belongs to the UPF0149 family
H9J99_RS14535	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H9J99_RS14545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9J99_RS14550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H9J99_RS14555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9J99_RS14565	COG0583	DNA-binding transcription factor activity
H9J99_RS14575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9J99_RS14585	COG0668	transmembrane transport
H9J99_RS14590	COG0191	fructose-bisphosphate aldolase activity
H9J99_RS14595	COG0126	phosphoglycerate kinase activity
H9J99_RS14600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9J99_RS14605	COG4771	TonB-dependent receptor
H9J99_RS14610	COG0583	DNA-binding transcription factor activity
H9J99_RS14615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9J99_RS14620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9J99_RS14630	COG3091	SprT-like family
H9J99_RS14635	COG2356	endonuclease I
H9J99_RS14640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9J99_RS14645	COG0189	ligase activity
H9J99_RS14650	COG1678	Uncharacterized ACR, COG1678
H9J99_RS14655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9J99_RS14670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9J99_RS14675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9J99_RS14680	COG0762	integral membrane protein
H9J99_RS14685	COG1872	DUF167
H9J99_RS14695	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9J99_RS14700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9J99_RS14705	COG2066	Belongs to the glutaminase family
H9J99_RS14715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9J99_RS14725	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H9J99_RS14730	COG0741	lytic transglycosylase activity
H9J99_RS14800	COG1012	belongs to the aldehyde dehydrogenase family
H9J99_RS14845	COG3437	response regulator, receiver
H9J99_RS14855	COG3394	polysaccharide catabolic process
H9J99_RS14860	COG1486	melibiose metabolic process
H9J99_RS14865	COG1447	Phosphotransferase system cellobiose-specific component IIA
H9J99_RS14870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9J99_RS14875	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9J99_RS14880	COG0726	polysaccharide deacetylase
H9J99_RS14915	COG1061	Type III restriction enzyme res subunit
H9J99_RS15020	COG1028	Short-chain dehydrogenase reductase Sdr
H9J99_RS15035	COG0795	lipopolysaccharide-transporting ATPase activity
H9J99_RS15045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9J99_RS15050	COG2927	DNA polymerase III (CHI subunit)
H9J99_RS15055	COG0525	valine-tRNA ligase activity
H9J99_RS15110	COG2235	arginine
H9J99_RS15115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9J99_RS15125	COG0540	Belongs to the ATCase OTCase family
H9J99_RS15130	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H9J99_RS15135	COG0251	oxidation-reduction process
H9J99_RS15140	COG0204	Acyl-transferase
H9J99_RS15145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9J99_RS15150	COG5007	Belongs to the BolA IbaG family
H9J99_RS15160	COG2854	intermembrane phospholipid transfer
H9J99_RS15165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9J99_RS15170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9J99_RS15175	COG1127	ABC transporter
H9J99_RS15185	COG0517	IMP dehydrogenase activity
H9J99_RS15185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H9J99_RS15195	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H9J99_RS15200	COG1137	ATPase activity
H9J99_RS15210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9J99_RS15215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9J99_RS15220	COG1660	Displays ATPase and GTPase activities
H9J99_RS15225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9J99_RS15230	COG2239	Acts as a magnesium transporter
H9J99_RS15235	COG0312	modulator of DNA gyrase
H9J99_RS15240	COG3028	Belongs to the UPF0307 family
H9J99_RS15245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9J99_RS15250	COG0564	pseudouridine synthase activity
H9J99_RS15260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9J99_RS15265	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H9J99_RS15275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9J99_RS15280	COG3164	Protein of unknown function
H9J99_RS15290	COG0424	maF-like protein
H9J99_RS15295	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H9J99_RS15300	COG1792	Involved in formation and maintenance of cell shape
H9J99_RS15305	COG1077	Cell shape determining protein MreB Mrl
H9J99_RS15350	COG1459	type II secretion system
H9J99_RS15355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9J99_RS15365	COG3267	Type II secretory pathway component ExeA
H9J99_RS15365	COG3409	Peptidoglycan-binding domain 1 protein
H9J99_RS15390	COG2200	EAL domain
H9J99_RS15390	COG2199	diguanylate cyclase activity
H9J99_RS15395	COG0629	single-stranded DNA binding
H9J99_RS15410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9J99_RS15425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H9J99_RS15430	COG0527	aspartate kinase activity
H9J99_RS15435	COG1410	methionine synthase
H9J99_RS15435	COG0646	methionine synthase
H9J99_RS15505	COG0175	sulfate reduction
H9J99_RS15510	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9J99_RS15515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H9J99_RS15535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9J99_RS15540	COG0735	belongs to the Fur family
H9J99_RS15550	COG0166	Belongs to the GPI family
H9J99_RS15555	COG0432	Pfam Uncharacterised protein family UPF0047
H9J99_RS15565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9J99_RS15580	COG0359	binds to the 23S rRNA
H9J99_RS15590	COG2965	DNA replication, synthesis of RNA primer
H9J99_RS15595	COG0360	Binds together with S18 to 16S ribosomal RNA
H9J99_RS15600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9J99_RS15605	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H9J99_RS15615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9J99_RS15620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9J99_RS15650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H9J99_RS15660	COG0678	peroxiredoxin activity
H9J99_RS15660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9J99_RS15670	COG0165	Argininosuccinate lyase
H9J99_RS15670	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9J99_RS15675	COG0137	argininosuccinate synthase activity
H9J99_RS15680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9J99_RS15685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9J99_RS15690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9J99_RS15695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9J99_RS15705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H9J99_RS15710	COG0460	homoserine dehydrogenase
H9J99_RS15710	COG0527	aspartate kinase activity
H9J99_RS15715	COG0626	cystathionine gamma-synthase activity
H9J99_RS15725	COG0281	malic enzyme
H9J99_RS15735	COG2906	2 iron, 2 sulfur cluster binding
H9J99_RS15740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9J99_RS15745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9J99_RS15750	COG0049	tRNA binding
H9J99_RS15760	COG2168	tRNA wobble position uridine thiolation
H9J99_RS15765	COG2923	Belongs to the DsrF TusC family
H9J99_RS15770	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H9J99_RS15775	COG2964	Protein conserved in bacteria
H9J99_RS15780	COG0545	Peptidyl-prolyl cis-trans isomerase
H9J99_RS15790	COG2900	Belongs to the SlyX family
H9J99_RS15795	COG1446	asparaginase
H9J99_RS15800	COG1047	Peptidyl-prolyl cis-trans
H9J99_RS15815	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9J99_RS15820	COG0488	(ABC) transporter
H9J99_RS15830	COG0429	hydrolase of the alpha beta-hydrolase fold
H9J99_RS15835	COG3089	Belongs to the UPF0270 family
H9J99_RS15840	COG3954	Phosphoribulokinase
H9J99_RS15845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9J99_RS15855	COG1012	belongs to the aldehyde dehydrogenase family
H9J99_RS15865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9J99_RS15870	COG0512	Glutamine amidotransferase of anthranilate synthase
H9J99_RS15885	COG0180	Tryptophanyl-tRNA synthetase
H9J99_RS15890	COG0546	phosphoglycolate phosphatase activity
H9J99_RS15895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9J99_RS15900	COG0557	exoribonuclease II activity
H9J99_RS15905	COG1959	2 iron, 2 sulfur cluster binding
H9J99_RS15910	COG1017	nitric oxide dioxygenase activity
H9J99_RS15910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9J99_RS15915	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H9J99_RS15920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9J99_RS15925	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H9J99_RS15930	COG0330	HflC and HflK could
H9J99_RS15935	COG0330	HflC and HflK could
H9J99_RS15940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9J99_RS15950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9J99_RS15955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9J99_RS15965	COG0802	atpase or kinase
H9J99_RS15970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9J99_RS16045	COG1162	GTPase activity
H9J99_RS16050	COG0688	phosphatidylethanolamine metabolic process
H9J99_RS16055	COG0471	metal ion transport
H9J99_RS16070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H9J99_RS16075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9J99_RS16080	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H9J99_RS16085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9J99_RS16090	COG1045	serine acetyltransferase
H9J99_RS16095	COG4942	peptidase
H9J99_RS16115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H9J99_RS16120	COG1053	succinate dehydrogenase
H9J99_RS16125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9J99_RS16130	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H9J99_RS16135	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H9J99_RS16145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9J99_RS16150	COG1509	lysine 2,3-aminomutase activity
H9J99_RS16155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9J99_RS16170	COG0459	protein refolding
H9J99_RS16180	COG0534	Mate efflux family protein
H9J99_RS16185	COG0205	6-phosphofructokinase activity
H9J99_RS16195	COG3678	ATP-independent chaperone mediated protein folding
H9J99_RS16200	COG0745	RESPONSE REGULATOR receiver
H9J99_RS16205	COG2205	protein histidine kinase activity
H9J99_RS16215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9J99_RS16220	COG3030	protein affecting phage T7 exclusion by the F plasmid
H9J99_RS16225	COG1027	Aspartate ammonia-lyase
H9J99_RS16230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9J99_RS16235	COG4232	protein-disulfide reductase activity
H9J99_RS16245	COG3263	regulation of cellular component size
H9J99_RS16255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9J99_RS16275	COG2198	Histidine kinase
H9J99_RS16275	COG0784	Response regulator, receiver
H9J99_RS16275	COG2205	protein histidine kinase activity
H9J99_RS16280	COG2814	Major facilitator Superfamily
H9J99_RS16295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9J99_RS16300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H9J99_RS16305	COG0511	ligase activity, forming carbon-carbon bonds
H9J99_RS16310	COG0439	Biotin carboxylase
H9J99_RS16315	COG2264	protein methyltransferase activity
H9J99_RS16320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9J99_RS16325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H9J99_RS16330	COG2814	Major facilitator Superfamily
H9J99_RS16335	COG0488	(ABC) transporter
H9J99_RS16340	COG3706	GGDEF domain
H9J99_RS16405	COG1982	Orn Lys Arg decarboxylase major
H9J99_RS16410	COG0531	amino acid
H9J99_RS16415	COG3710	Transcriptional regulator
H9J99_RS16420	COG0789	Transcriptional regulator
H9J99_RS16425	COG0138	bifunctional purine biosynthesis protein purh
H9J99_RS16430	COG0151	Belongs to the GarS family
H9J99_RS16445	COG1253	flavin adenine dinucleotide binding
H9J99_RS16455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9J99_RS16460	COG1573	uracil-dna glycosylase
H9J99_RS16465	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9J99_RS16480	COG2816	NAD+ diphosphatase activity
H9J99_RS16485	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H9J99_RS16490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9J99_RS16495	COG0085	RNA polymerase activity
H9J99_RS16500	COG0222	ribosome binding
H9J99_RS16505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9J99_RS16510	COG0081	regulation of translation
H9J99_RS16515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9J99_RS16520	COG0250	Participates in transcription elongation, termination and antitermination
H9J99_RS16525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9J99_RS16530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9J99_RS16565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9J99_RS16575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9J99_RS16610	COG0596	Alpha beta hydrolase
H9J99_RS16650	COG1278	Cold shock
H9J99_RS16660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H9J99_RS16675	COG2826	transposase and inactivated derivatives, IS30 family
H9J99_RS16710	COG1214	PFAM Peptidase M22, glycoprotease
H9J99_RS16710	COG0456	acetyltransferase
H9J99_RS16725	COG3069	C4-dicarboxylate transmembrane transporter activity
H9J99_RS16730	COG1704	LemA family
H9J99_RS16735	COG0501	Belongs to the peptidase M48B family
H9J99_RS16760	COG0641	radical SAM
H9J99_RS16775	COG3111	PFAM Bacterial OB fold (BOF) protein
H9J99_RS16780	COG1597	lipid kinase activity
H9J99_RS16785	COG0583	DNA-binding transcription factor activity
H9J99_RS16820	COG0714	Associated with various cellular activities
H9J99_RS16825	COG0641	radical SAM
H9J99_RS16830	COG3119	arylsulfatase activity
H9J99_RS16845	COG3119	arylsulfatase activity
H9J99_RS16850	COG3119	arylsulfatase activity
H9J99_RS16855	COG0745	RESPONSE REGULATOR receiver
H9J99_RS16870	COG0784	Response regulator, receiver
H9J99_RS16870	COG2198	Histidine kinase
H9J99_RS16870	COG2205	protein histidine kinase activity
H9J99_RS16875	COG1879	ABC-type sugar transport system periplasmic component
H9J99_RS16880	COG1803	Methylglyoxal synthase
H9J99_RS16885	COG0210	DNA helicase
H9J99_RS16890	COG1289	transmembrane transporter activity
H9J99_RS16920	COG4771	TonB-dependent receptor
H9J99_RS16920	COG1629	transport
H9J99_RS16930	COG0789	Transcriptional regulator
H9J99_RS16935	COG4604	ABC transporter, ATP-binding protein
H9J99_RS16940	COG4605	iron ion homeostasis
H9J99_RS16945	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9J99_RS16950	COG4607	ABC-type enterochelin transport system periplasmic component
H9J99_RS16960	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H9J99_RS16975	COG1609	Transcriptional regulator
H9J99_RS16980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9J99_RS16985	COG1879	ABC-type sugar transport system periplasmic component
H9J99_RS16990	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9J99_RS16995	COG1129	ABC transporter
H9J99_RS17000	COG1869	D-ribose catabolic process
H9J99_RS17005	COG5001	Diguanylate cyclase
H9J99_RS17010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9J99_RS17065	COG0784	Response regulator, receiver
H9J99_RS17065	COG2205	protein histidine kinase activity
H9J99_RS17075	COG3300	MHYT domain
H9J99_RS17075	COG5001	Diguanylate cyclase
H9J99_RS17085	COG0330	HflC and HflK could
H9J99_RS17100	COG0517	IMP dehydrogenase activity
H9J99_RS17100	COG4175	Glycine betaine
H9J99_RS17130	COG1012	belongs to the aldehyde dehydrogenase family
H9J99_RS17135	COG1309	transcriptional regulator
H9J99_RS17140	COG3706	GGDEF domain
H9J99_RS17145	COG1028	Short-chain dehydrogenase reductase Sdr
H9J99_RS17160	COG1024	Enoyl-CoA hydratase
H9J99_RS17165	COG1960	acyl-CoA dehydrogenase activity
H9J99_RS17175	COG0183	Belongs to the thiolase family
H9J99_RS17185	COG1960	acyl-CoA dehydrogenase activity
H9J99_RS17190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9J99_RS17195	COG1024	Enoyl-CoA hydratase
H9J99_RS17200	COG4770	biotin carboxylase activity
H9J99_RS17210	COG2205	protein histidine kinase activity
H9J99_RS17210	COG3437	response regulator, receiver
H9J99_RS17210	COG3850	Histidine kinase
H9J99_RS17210	COG4999	Histidine kinase
H9J99_RS17225	COG3264	Mechanosensitive ion channel
H9J99_RS17225	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H9J99_RS17230	COG0110	maltose O-acetyltransferase activity
H9J99_RS17235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9J99_RS17240	COG1271	oxidase subunit
H9J99_RS17245	COG1294	oxidase, subunit
H9J99_RS17260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H9J99_RS17265	COG0789	Transcriptional regulator
H9J99_RS17335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9J99_RS17355	COG3335	DDE superfamily endonuclease
H9J99_RS17470	COG0455	bacterial-type flagellum organization
H9J99_RS17515	COG2356	endonuclease I
H9J99_RS17600	COG0693	protein deglycase activity
H9J99_RS17620	COG1012	belongs to the aldehyde dehydrogenase family
H9J99_RS17630	COG2199	diguanylate cyclase activity
H9J99_RS17630	COG2200	EAL domain
H9J99_RS17630	COG2202	Pas domain
H9J99_RS17655	COG3385	transposase activity
H9J99_RS17660	COG0840	transmembrane signaling receptor activity
H9J99_RS17740	COG1484	DNA-dependent DNA replication
H9J99_RS17770	COG3852	Histidine kinase
H9J99_RS17780	COG0582	viral genome integration into host DNA
H9J99_RS17785	COG0516	GMP reductase activity
H9J99_RS17790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9J99_RS17790	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9J99_RS17805	COG4989	oxidoreductase activity
H9J99_RS17820	COG0038	chloride channel
H9J99_RS17830	COG1914	H( )-stimulated, divalent metal cation uptake system
H9J99_RS17835	COG0302	gtp cyclohydrolase
H9J99_RS17845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9J99_RS17865	COG2897	thiosulfate sulfurtransferase activity
H9J99_RS17885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9J99_RS17890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9J99_RS17895	COG0840	transmembrane signaling receptor activity
H9J99_RS17900	COG2814	Major facilitator Superfamily
H9J99_RS17905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9J99_RS17915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9J99_RS17925	COG0840	transmembrane signaling receptor activity
H9J99_RS17945	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9J99_RS17960	COG2197	response regulator
H9J99_RS17965	COG3850	Histidine kinase
H9J99_RS17970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9J99_RS17980	COG0243	molybdopterin cofactor binding
H9J99_RS17990	COG3005	denitrification pathway
H9J99_RS18010	COG0183	Belongs to the thiolase family
H9J99_RS18025	COG1280	lysine exporter protein (LysE YggA)
H9J99_RS18035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9J99_RS18040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9J99_RS18065	COG1522	sequence-specific DNA binding
H9J99_RS18085	COG1566	PFAM secretion protein HlyD family protein
H9J99_RS18095	COG2205	protein histidine kinase activity
H9J99_RS18095	COG0784	Response regulator, receiver
H9J99_RS18100	COG1879	ABC-type sugar transport system periplasmic component
H9J99_RS18105	COG2827	Endonuclease containing a URI domain
H9J99_RS18110	COG3132	Protein of unknown function, DUF480
H9J99_RS18120	COG2926	Belongs to the UPF0265 family
H9J99_RS18125	COG0534	Mate efflux family protein
H9J99_RS18130	COG0673	inositol 2-dehydrogenase activity
H9J99_RS18155	COG0583	DNA-binding transcription factor activity
H9J99_RS18160	COG1522	sequence-specific DNA binding
H9J99_RS18165	COG0531	amino acid
H9J99_RS18180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9J99_RS18190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H9J99_RS18195	COG0402	S-adenosylhomocysteine deaminase activity
H9J99_RS18205	COG1418	mRNA catabolic process
H9J99_RS18215	COG2814	Major facilitator Superfamily
H9J99_RS18225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9J99_RS18245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9J99_RS18260	COG4221	oxidoreductase activity
H9J99_RS18265	COG0745	RESPONSE REGULATOR receiver
H9J99_RS18270	COG2205	protein histidine kinase activity
H9J99_RS18280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9J99_RS18285	COG2194	sulfuric ester hydrolase activity
H9J99_RS18290	COG0673	inositol 2-dehydrogenase activity
H9J99_RS18325	COG4667	esterase of the alpha-beta hydrolase superfamily
H9J99_RS18330	COG1741	Belongs to the pirin family
H9J99_RS18335	COG1278	Cold shock
H9J99_RS18350	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9J99_RS18365	COG1686	Belongs to the peptidase S11 family
H9J99_RS18370	COG0625	glutathione transferase activity
H9J99_RS18380	COG1621	beta-fructofuranosidase activity
H9J99_RS18385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9J99_RS18390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9J99_RS18390	COG1263	PTS System
H9J99_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
H9J99_RS18445	COG2207	Transcriptional regulator
H9J99_RS18445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9J99_RS18450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9J99_RS18470	COG0513	Belongs to the DEAD box helicase family
H9J99_RS18480	COG0583	DNA-binding transcription factor activity
H9J99_RS18495	COG1902	pentaerythritol trinitrate reductase activity
H9J99_RS18500	COG1063	alcohol dehydrogenase
H9J99_RS18510	COG1028	Short-chain dehydrogenase reductase Sdr
H9J99_RS18520	COG3122	Protein conserved in bacteria
H9J99_RS18535	COG0583	DNA-binding transcription factor activity
H9J99_RS18540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9J99_RS18550	COG0252	asparaginase activity
H9J99_RS18555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9J99_RS18560	COG0574	Belongs to the PEP-utilizing enzyme family
H9J99_RS18560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9J99_RS18575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9J99_RS18595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9J99_RS18615	COG3706	GGDEF domain
H9J99_RS18635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9J99_RS18665	COG3842	ATPase activity
H9J99_RS18710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9J99_RS18745	COG0583	DNA-binding transcription factor activity
H9J99_RS18755	COG4948	Mandelate Racemase Muconate Lactonizing
H9J99_RS18785	COG1342	Belongs to the UPF0251 family
H9J99_RS18790	COG3015	lipoprotein NlpE involved in copper resistance
H9J99_RS18795	COG3713	MltA-interacting MipA family protein
H9J99_RS18810	COG0583	DNA-binding transcription factor activity
H9J99_RS18835	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9J99_RS18845	COG1335	isochorismatase
H9J99_RS18855	COG0753	catalase activity
H9J99_RS18865	COG1349	DNA-binding transcription factor activity
H9J99_RS18870	COG0346	lactoylglutathione lyase activity
H9J99_RS18890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9J99_RS18895	COG3537	Alpha-1,2-mannosidase
H9J99_RS18900	COG3537	Alpha-1,2-mannosidase
H9J99_RS18910	COG3537	Alpha-1,2-mannosidase
H9J99_RS18915	COG3537	Alpha-1,2-mannosidase
H9J99_RS18920	COG2070	2-Nitropropane dioxygenase
H9J99_RS18925	COG0737	Belongs to the 5'-nucleotidase family
H9J99_RS18935	COG1309	transcriptional regulator
H9J99_RS18970	COG0459	protein refolding
H9J99_RS18975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9J99_RS18980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9J99_RS18995	COG1304	FMN binding
H9J99_RS19015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9J99_RS19030	COG1706	bacterial-type flagellum-dependent cell motility
H9J99_RS19035	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H9J99_RS19040	COG4786	Flagellar basal body rod
H9J99_RS19045	COG4787	bacterial-type flagellum-dependent cell motility
H9J99_RS19050	COG1749	Flagellar hook protein flgE
H9J99_RS19055	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H9J99_RS19060	COG1558	bacterial-type flagellum-dependent cell motility
H9J99_RS19065	COG1815	bacterial-type flagellum-dependent cell motility
H9J99_RS19085	COG0741	lytic transglycosylase activity
H9J99_RS19090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9J99_RS19110	COG1760	l-serine dehydratase
H9J99_RS19115	COG3104	oligopeptide transport
H9J99_RS19135	COG0583	DNA-binding transcription factor activity
H9J99_RS19145	COG2866	Carboxypeptidase
H9J99_RS19150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9J99_RS19160	COG2990	Protein conserved in bacteria
H9J99_RS19185	COG3842	ATPase activity
H9J99_RS19195	COG1840	ABC-type Fe3 transport system, periplasmic component
H9J99_RS19200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H9J99_RS19205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H9J99_RS19210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9J99_RS19215	COG1609	Transcriptional regulator
H9J99_RS19245	COG3240	lipase activity
H9J99_RS19250	COG2067	long-chain fatty acid transport protein
H9J99_RS19260	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H9J99_RS19275	COG1011	Hydrolase
H9J99_RS19315	COG0110	maltose O-acetyltransferase activity
H9J99_RS19320	COG1765	OsmC-like protein
H9J99_RS19335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9J99_RS19345	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H9J99_RS19350	COG3421	Type III restriction
H9J99_RS19645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9J99_RS19645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9J99_RS19660	COG3046	protein related to deoxyribodipyrimidine photolyase
H9J99_RS19665	COG0415	Belongs to the DNA photolyase family
H9J99_RS19670	COG3706	GGDEF domain
H9J99_RS19685	COG0840	transmembrane signaling receptor activity
H9J99_RS19690	COG3706	GGDEF domain
H9J99_RS19705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9J99_RS19720	COG3033	Beta-eliminating lyase
H9J99_RS19730	COG0579	oxidoreductase
H9J99_RS19750	COG2199	diguanylate cyclase activity
H9J99_RS19755	COG2204	response regulator
H9J99_RS19760	COG4191	Histidine kinase
H9J99_RS19795	COG0583	DNA-binding transcription factor activity
H9J99_RS19800	COG0189	ligase activity
H9J99_RS19805	COG0189	ligase activity
H9J99_RS19805	COG4067	protein conserved in archaea
H9J99_RS19815	COG1166	arginine decarboxylase activity
H9J99_RS19820	COG0010	Belongs to the arginase family
H9J99_RS19825	COG2814	Major facilitator Superfamily
H9J99_RS19830	COG1770	oligopeptidase
H9J99_RS19845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9J99_RS19850	COG1121	(ABC) transporter
H9J99_RS19855	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9J99_RS19895	COG0848	biopolymer transport protein
H9J99_RS19900	COG0811	peptide transport
H9J99_RS19905	COG0811	peptide transport
H9J99_RS19925	COG0745	RESPONSE REGULATOR receiver
H9J99_RS19930	COG0039	L-malate dehydrogenase activity
H9J99_RS19935	COG0584	glycerophosphoryl diester phosphodiesterase
H9J99_RS19945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9J99_RS20000	COG1901	pseudouridine methyltransferase
H9J99_RS20005	COG0312	modulator of DNA gyrase
H9J99_RS20010	COG0312	modulator of DNA gyrase
H9J99_RS20015	COG0351	phosphomethylpyrimidine kinase
H9J99_RS20020	COG1116	anion transmembrane transporter activity
H9J99_RS20025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9J99_RS20030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9J99_RS20035	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9J99_RS20040	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H9J99_RS20045	COG0352	thiamine-phosphate diphosphorylase activity
H9J99_RS20055	COG0243	molybdopterin cofactor binding
H9J99_RS20060	COG3005	denitrification pathway
H9J99_RS20070	COG1028	Short-chain dehydrogenase reductase Sdr
H9J99_RS20085	COG0456	acetyltransferase
H9J99_RS20105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9J99_RS20110	COG1929	Belongs to the glycerate kinase type-1 family
H9J99_RS20115	COG2610	gluconate transmembrane transporter activity
H9J99_RS20120	COG3835	regulator
H9J99_RS20160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H9J99_RS20165	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H9J99_RS20165	COG3408	Glycogen debranching enzyme
H9J99_RS20195	COG3047	cAMP biosynthetic process
H9J99_RS20200	COG1357	PFAM Pentapeptide repeats (8 copies)
H9J99_RS20235	COG2375	cellular response to nickel ion
H9J99_RS20240	COG0583	DNA-binding transcription factor activity
H9J99_RS20245	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H9J99_RS20250	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H9J99_RS20265	COG2199	diguanylate cyclase activity
H9J99_RS20275	COG0561	phosphatase activity
H9J99_RS20280	COG0583	DNA-binding transcription factor activity
H9J99_RS20295	COG0564	pseudouridine synthase activity
H9J99_RS20300	COG0534	Mate efflux family protein
H9J99_RS20305	COG5001	Diguanylate cyclase
H9J99_RS20315	COG3123	guanosine phosphorylase activity
H9J99_RS20355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9J99_RS20365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9J99_RS20370	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H9J99_RS20380	COG2259	Doxx family
H9J99_RS20385	COG1741	Belongs to the pirin family
H9J99_RS20405	COG0363	glucosamine-6-phosphate deaminase activity
H9J99_RS20415	COG0786	glutamate:sodium symporter activity
H9J99_RS20420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9J99_RS20425	COG1131	(ABC) transporter
H9J99_RS20435	COG0786	glutamate:sodium symporter activity
H9J99_RS20460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9J99_RS20470	COG3279	Response regulator of the LytR AlgR family
H9J99_RS20475	COG3275	phosphorelay sensor kinase activity
H9J99_RS20495	COG1136	(ABC) transporter
H9J99_RS20505	COG0772	Belongs to the SEDS family
H9J99_RS20510	COG0217	transcriptional regulatory protein
H9J99_RS20540	COG0444	Belongs to the ABC transporter superfamily
H9J99_RS20545	COG4608	Belongs to the ABC transporter superfamily
H9J99_RS20570	COG1444	tRNA N-acetyltransferase activity
H9J99_RS20590	COG3340	Belongs to the peptidase S51 family
H9J99_RS20595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9J99_RS20600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9J99_RS20600	COG1263	PTS System
H9J99_RS20605	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9J99_RS20620	COG4166	transmembrane transport
H9J99_RS20670	COG0259	pyridoxamine-phosphate oxidase activity
H9J99_RS20695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9J99_RS20770	COG0800	Aldolase
H9J99_RS20775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9J99_RS20785	COG0246	Mannitol dehydrogenase
H9J99_RS20795	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9J99_RS20805	COG2186	Transcriptional regulator
H9J99_RS20815	COG0513	Belongs to the DEAD box helicase family
H9J99_RS20820	COG2258	MOSC domain
H9J99_RS20835	COG1486	melibiose metabolic process
H9J99_RS20840	COG0583	DNA-binding transcription factor activity
H9J99_RS20855	COG1595	DNA-templated transcription, initiation
H9J99_RS20880	COG3634	alkyl hydroperoxide reductase activity
H9J99_RS20890	COG1846	Transcriptional regulator
H9J99_RS20895	COG1764	response to oxidative stress
H9J99_RS20920	COG2160	L-arabinose isomerase activity
H9J99_RS20930	COG1069	ribulokinase activity
H9J99_RS20935	COG1069	ribulokinase activity
H9J99_RS20940	COG1879	ABC-type sugar transport system periplasmic component
H9J99_RS20945	COG1129	ABC transporter
H9J99_RS20950	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9J99_RS20955	COG0826	peptidase U32
H9J99_RS20980	COG1653	transport
H9J99_RS20985	COG0019	diaminopimelate decarboxylase activity
H9J99_RS20990	COG4264	IucA IucC family
H9J99_RS21015	COG4772	TonB-dependent receptor
H9J99_RS21020	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9J99_RS21025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9J99_RS21030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9J99_RS21035	COG1120	ATPase activity
H9J99_RS21040	COG0840	transmembrane signaling receptor activity
H9J99_RS21045	COG0612	Peptidase, M16
H9J99_RS21055	COG0739	heme binding
H9J99_RS21080	COG4580	involved in the transport of maltose and maltodextrins
H9J99_RS21100	COG2356	endonuclease I
H9J99_RS21130	COG3423	Transcriptional regulator
H9J99_RS21230	COG5566	PFAM Mor transcription activator
H9J99_RS21260	COG0640	Transcriptional regulator
H9J99_RS21270	COG4373	Mu-like prophage FluMu protein gp28
H9J99_RS21275	COG4383	Mu-like prophage protein gp29
H9J99_RS21295	COG4388	Caudovirus prohead serine protease
H9J99_RS21305	COG4397	Mu-like prophage major head subunit gpT
H9J99_RS21315	COG4387	Mu-like prophage protein GP36
H9J99_RS21385	COG0531	amino acid
H9J99_RS21395	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H9J99_RS21405	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H9J99_RS21410	COG1162	GTPase activity
H9J99_RS21415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9J99_RS21415	COG1263	PTS System
H9J99_RS21425	COG1999	signal sequence binding
H9J99_RS21440	COG2909	trisaccharide binding
H9J99_RS21445	COG0058	SHG alpha-glucan phosphorylase activity
H9J99_RS21450	COG1640	4-alpha-glucanotransferase
H9J99_RS21455	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H9J99_RS21460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9J99_RS21465	COG0366	Alpha amylase catalytic
H9J99_RS21480	COG3366	ferrous iron transmembrane transporter activity
H9J99_RS21485	COG0700	Nucleoside recognition
H9J99_RS21490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9J99_RS21495	COG3339	Conserved Protein
H9J99_RS21500	COG1301	dicarboxylic acid transport
H9J99_RS21530	COG0583	DNA-binding transcription factor activity
H9J99_RS21560	COG2095	MarC family integral membrane protein
H9J99_RS21565	COG4667	esterase of the alpha-beta hydrolase superfamily
H9J99_RS21570	COG3397	chitin binding
H9J99_RS21580	COG1054	Belongs to the UPF0176 family
H9J99_RS21595	COG1686	Belongs to the peptidase S11 family
H9J99_RS21620	COG0583	DNA-binding transcription factor activity
H9J99_RS21625	COG4628	conserved protein (DUF2132)
H9J99_RS21635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9J99_RS21645	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9J99_RS21650	COG0628	permease
H9J99_RS21690	COG2814	Major facilitator Superfamily
H9J99_RS21700	COG0454	-acetyltransferase
H9J99_RS21710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9J99_RS21715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9J99_RS21720	COG1882	Formate acetyltransferase
H9J99_RS21750	COG1360	Flagellar Motor Protein
H9J99_RS21755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H9J99_RS21760	COG1191	sigma factor activity
H9J99_RS21765	COG1580	Controls the rotational direction of flagella during chemotaxis
H9J99_RS21780	COG1516	flagellar protein fliS
H9J99_RS21785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H9J99_RS21805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9J99_RS21820	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H9J99_RS21830	COG1987	bacterial-type flagellum assembly
H9J99_RS21920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9J99_RS21940	COG0346	lactoylglutathione lyase activity
H9J99_RS21965	COG0745	RESPONSE REGULATOR receiver
H9J99_RS21985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9J99_RS21995	COG0156	8-amino-7-oxononanoate synthase activity
H9J99_RS22000	COG1063	alcohol dehydrogenase
H9J99_RS22035	COG0668	transmembrane transport
H9J99_RS22045	COG1304	FMN binding
H9J99_RS22050	COG1620	l-lactate permease
H9J99_RS22055	COG0583	DNA-binding transcription factor activity
H9J99_RS22060	COG1505	serine-type exopeptidase activity
H9J99_RS22065	COG4172	Belongs to the ABC transporter superfamily
H9J99_RS22075	COG1067	ATP-dependent peptidase activity
H9J99_RS22100	COG1247	-acetyltransferase
H9J99_RS22105	COG0437	4 iron, 4 sulfur cluster binding
H9J99_RS22110	COG0348	domain, Protein
H9J99_RS22125	COG1122	ATPase activity
H9J99_RS22130	COG4720	Psort location CytoplasmicMembrane, score
H9J99_RS22135	COG1566	PFAM secretion protein HlyD family protein
H9J99_RS22145	COG3706	GGDEF domain
H9J99_RS22160	COG0813	purine-nucleoside phosphorylase activity
H9J99_RS22165	COG3272	Protein of unknown function (DUF1722)
H9J99_RS22170	COG0789	Transcriptional regulator
H9J99_RS22175	COG0415	Belongs to the DNA photolyase family
H9J99_RS22180	COG1376	ErfK ybiS ycfS ynhG family protein
H9J99_RS22180	COG1388	LysM domain
H9J99_RS22190	COG0513	Belongs to the DEAD box helicase family
H9J99_RS22195	COG1770	oligopeptidase
H9J99_RS22200	COG4771	TonB-dependent receptor
H9J99_RS22230	COG0573	inorganic phosphate transmembrane transporter activity
H9J99_RS22235	COG0581	inorganic phosphate transmembrane transporter activity
H9J99_RS22240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9J99_RS22275	COG0714	Associated with various cellular activities
H9J99_RS22280	COG0840	transmembrane signaling receptor activity
H9J99_RS22340	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9J99_RS22345	COG1120	ATPase activity
H9J99_RS22350	COG4774	siderophore transport
H9J99_RS22355	COG1132	(ABC) transporter
H9J99_RS22370	COG0569	domain protein
H9J99_RS22375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9J99_RS22385	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H9J99_RS22390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9J99_RS22405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9J99_RS22405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9J99_RS22405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9J99_RS22410	COG2207	Transcriptional regulator
H9J99_RS22420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9J99_RS22425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9J99_RS22430	COG2084	Dehydrogenase
H9J99_RS22435	COG0753	catalase activity
H9J99_RS22445	COG2130	NADP-dependent
H9J99_RS22450	COG1309	transcriptional regulator
H9J99_RS22455	COG3097	Belongs to the UPF0267 family
H9J99_RS22515	COG3842	ATPase activity
H9J99_RS22525	COG1175	transmembrane transport
H9J99_RS22530	COG3833	ABC-type maltose transport systems, permease component
H9J99_RS22560	COG2354	Protein conserved in bacteria
H9J99_RS22565	COG0418	dihydroorotase activity
H9J99_RS22570	COG0401	homolog of Blt101
H9J99_RS22575	COG3217	Mosc domain protein beta barrel domain protein
H9J99_RS22575	COG0633	Ferredoxin
H9J99_RS22575	COG3217	Mosc domain protein beta barrel domain protein
H9J99_RS22575	COG0633	Ferredoxin
H9J99_RS22580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9J99_RS22585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9J99_RS22625	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H9J99_RS22630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9J99_RS22640	COG0848	biopolymer transport protein
H9J99_RS22645	COG0811	peptide transport
H9J99_RS22650	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H9J99_RS22660	COG3721	Heme iron utilization protein
H9J99_RS22665	COG0748	coenzyme F420 binding
H9J99_RS22675	COG0784	Response regulator, receiver
H9J99_RS22675	COG0835	chemotaxis
H9J99_RS22680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9J99_RS22715	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9J99_RS22720	COG0783	Belongs to the Dps family
H9J99_RS22725	COG0583	DNA-binding transcription factor activity
H9J99_RS22740	COG4934	collagen metabolic process
H9J99_RS22750	COG0366	Alpha amylase catalytic
H9J99_RS22770	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9J99_RS22775	COG0589	response to stress
H9J99_RS22780	COG0488	(ABC) transporter
H9J99_RS22785	COG1505	serine-type exopeptidase activity
H9J99_RS22800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9J99_RS22810	COG2067	long-chain fatty acid transport protein
H9J99_RS22820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9J99_RS22850	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9J99_RS22870	COG3383	formate dehydrogenase (NAD+) activity
H9J99_RS22885	COG0842	Transport permease protein
H9J99_RS22890	COG1131	(ABC) transporter
H9J99_RS22905	COG2706	6-phosphogluconolactonase activity
H9J99_RS22915	COG1881	PFAM PEBP family protein
H9J99_RS22925	COG0798	PFAM Bile acid sodium symporter
H9J99_RS22940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9J99_RS22945	COG2213	PTS system mannitol-specific
H9J99_RS22950	COG1063	alcohol dehydrogenase
H9J99_RS22960	COG1072	(Pantothenic acid kinase))
H9J99_RS22965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9J99_RS22985	COG0814	amino acid
H9J99_RS22995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9J99_RS23025	COG3314	Sporulation integral membrane protein YlbJ
H9J99_RS23045	COG0739	heme binding
H9J99_RS23065	COG0583	DNA-binding transcription factor activity
H9J99_RS23070	COG2814	Major facilitator Superfamily
H9J99_RS23085	COG0697	spore germination
H9J99_RS23090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9J99_RS23115	COG2207	Transcriptional regulator
H9J99_RS23140	COG1045	serine acetyltransferase
H9J99_RS23145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9J99_RS23150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9J99_RS23160	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H9J99_RS23185	COG1612	heme a metabolic process
H9J99_RS23190	COG0109	protoheme IX farnesyltransferase activity
H9J99_RS23195	COG0545	Peptidyl-prolyl cis-trans isomerase
H9J99_RS23225	COG1278	Cold shock
H9J99_RS23230	COG3036	rescue of stalled ribosome
H9J99_RS23235	COG0840	transmembrane signaling receptor activity
H9J99_RS23245	COG2199	diguanylate cyclase activity
H9J99_RS23265	COG0577	efflux transmembrane transporter activity
H9J99_RS23265	COG1136	(ABC) transporter
H9J99_RS23275	COG0840	transmembrane signaling receptor activity
H9J99_RS23280	COG0783	Belongs to the Dps family
H9J99_RS23290	COG2133	pyrroloquinoline quinone binding
H9J99_RS23295	COG1454	alcohol dehydrogenase
H9J99_RS23300	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H9J99_RS23330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9J99_RS23335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9J99_RS23340	COG3186	Phenylalanine-4-hydroxylase
H9J99_RS23345	COG2154	pterin-4-alpha-carbinolamine dehydratase
H9J99_RS23365	COG3530	Putative quorum-sensing-regulated virulence factor
H9J99_RS23370	COG0513	Belongs to the DEAD box helicase family
H9J99_RS23375	COG4628	conserved protein (DUF2132)
H9J99_RS23380	COG0133	tryptophan synthase activity
H9J99_RS23390	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H9J99_RS23400	COG0523	cobalamin synthesis protein
H9J99_RS23405	COG0513	Belongs to the DEAD box helicase family
H9J99_RS23425	COG2200	EAL domain
H9J99_RS23430	COG1119	ATPase activity
H9J99_RS23455	COG0641	radical SAM
H9J99_RS23480	COG0582	viral genome integration into host DNA
H9J99_RS23535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9J99_RS23550	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H9J99_RS23555	COG0513	Belongs to the DEAD box helicase family
H9J99_RS23560	COG5001	Diguanylate cyclase
H9J99_RS23565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9J99_RS23580	COG5413	integral membrane protein
H9J99_RS23590	COG1024	Enoyl-CoA hydratase
H9J99_RS23595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9J99_RS23600	COG1960	acyl-CoA dehydrogenase activity
H9J99_RS23610	COG0183	Belongs to the thiolase family
H9J99_RS23625	COG1024	Enoyl-CoA hydratase
H9J99_RS23630	COG1024	Enoyl-CoA hydratase
H9J99_RS23640	COG1028	Short-chain dehydrogenase reductase Sdr
H9J99_RS23645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9J99_RS23650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9J99_RS23655	COG1845	cytochrome c oxidase, subunit III
H9J99_RS23660	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H9J99_RS23665	COG0109	protoheme IX farnesyltransferase activity
H9J99_RS23680	COG1902	pentaerythritol trinitrate reductase activity
H9J99_RS23690	COG1126	abc transporter atp-binding protein
H9J99_RS23695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9J99_RS23700	COG4215	(ABC) transporter
H9J99_RS23705	COG4160	amino acid transport
H9J99_RS23720	COG0625	glutathione transferase activity
H9J99_RS23755	COG0443	Heat shock 70 kDa protein
H9J99_RS23760	COG2847	Copper chaperone PCu(A)C
H9J99_RS23785	COG0745	RESPONSE REGULATOR receiver
H9J99_RS23800	COG1785	Belongs to the alkaline phosphatase family
H9J99_RS23825	COG0814	amino acid
H9J99_RS23835	COG0243	molybdopterin cofactor binding
H9J99_RS23840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9J99_RS23840	COG1648	precorrin-2 dehydrogenase activity
H9J99_RS23855	COG3707	response regulator
H9J99_RS23860	COG1116	anion transmembrane transporter activity
H9J99_RS23860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9J99_RS23865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9J99_RS23870	COG1116	anion transmembrane transporter activity
H9J99_RS23875	COG2146	nitrite reductase [NAD(P)H] activity
H9J99_RS23875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9J99_RS23930	COG0515	serine threonine protein kinase
H9J99_RS23930	COG2815	serine threonine protein kinase
H9J99_RS24035	COG0420	3'-5' exonuclease activity
H9J99_RS24040	COG0419	ATPase involved in DNA repair
H9J99_RS24060	COG3040	lipid binding
H9J99_RS24070	COG2814	Major facilitator Superfamily
H9J99_RS24080	COG1288	antiporter activity
H9J99_RS24090	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H9J99_RS24105	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H9J99_RS24120	COG0583	DNA-binding transcription factor activity
H9J99_RS24125	COG0277	FAD linked oxidase domain protein
H9J99_RS24140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9J99_RS24195	COG0840	transmembrane signaling receptor activity
H9J99_RS24235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9J99_RS24235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9J99_RS24270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9J99_RS24275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9J99_RS24285	COG2116	formate transmembrane transporter activity
H9J99_RS24305	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9J99_RS24335	COG0534	Mate efflux family protein
H9J99_RS24350	COG3118	belongs to the thioredoxin family
H9J99_RS24355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9J99_RS24380	COG2271	Major facilitator Superfamily
H9J99_RS24385	COG3851	Histidine kinase
H9J99_RS24390	COG2197	response regulator
H9J99_RS24400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H9J99_RS24405	COG0583	DNA-binding transcription factor activity
H9J99_RS24410	COG0243	molybdopterin cofactor binding
H9J99_RS24440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9J99_RS24455	COG1328	CTP reductase activity
H9J99_RS24460	COG0602	queuosine metabolic process
H9J99_RS24465	COG0534	Mate efflux family protein
H9J99_RS24480	COG4067	protein conserved in archaea
H9J99_RS24480	COG0189	ligase activity
H9J99_RS24490	COG3111	PFAM Bacterial OB fold (BOF) protein
H9J99_RS24495	COG1492	cobalamin metabolic process
H9J99_RS24500	COG0725	ABC transporter, periplasmic molybdate-binding protein
H9J99_RS24505	COG4149	molybdate abc transporter
H9J99_RS24510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H9J99_RS24520	COG2203	Gaf domain
H9J99_RS24520	COG3706	GGDEF domain
H9J99_RS24520	COG5001	Diguanylate cyclase
H9J99_RS24520	COG4251	negative regulation of phosphorylation
H9J99_RS24545	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H9J99_RS24550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H9J99_RS24580	COG3140	Belongs to the UPF0181 family
H9J99_RS24585	COG0589	response to stress
H9J99_RS24605	COG0023	Translation Initiation Factor
H9J99_RS24615	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9J99_RS24625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9J99_RS24625	COG1042	CoA-binding domain protein
H9J99_RS24625	COG0045	succinate-CoA ligase (ADP-forming) activity
H9J99_RS24630	COG0583	DNA-binding transcription factor activity
H9J99_RS24635	COG1629	transport
H9J99_RS24635	COG4771	TonB-dependent receptor
H9J99_RS24640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9J99_RS24645	COG5002	protein histidine kinase activity
H9J99_RS24645	COG5001	Diguanylate cyclase
H9J99_RS24645	COG3447	MASE1 domain protein
H9J99_RS24650	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H9J99_RS24655	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H9J99_RS24660	COG1984	allophanate hydrolase subunit 2
H9J99_RS24670	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H9J99_RS24675	COG4181	ATPase activity
H9J99_RS24685	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9J99_RS24690	COG5001	Diguanylate cyclase
H9J99_RS24690	COG3300	MHYT domain
H9J99_RS24700	COG0484	heat shock protein binding
H9J99_RS24725	COG4533	DNA binding
H9J99_RS24735	COG2050	protein possibly involved in aromatic compounds catabolism
H9J99_RS24750	COG2067	long-chain fatty acid transport protein
H9J99_RS24755	COG2267	carboxylic ester hydrolase activity
H9J99_RS24775	COG0861	Integral membrane protein TerC family
H9J99_RS24780	COG0737	Belongs to the 5'-nucleotidase family
H9J99_RS24785	COG3593	DNA synthesis involved in DNA repair
H9J99_RS24795	COG0583	DNA-binding transcription factor activity
H9J99_RS24800	COG2116	formate transmembrane transporter activity
H9J99_RS24805	COG2353	YceI-like domain
H9J99_RS24810	COG3038	cytochrome b561
H9J99_RS24825	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H9J99_RS24830	COG0513	Belongs to the DEAD box helicase family
H9J99_RS24835	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H9J99_RS24840	COG0840	transmembrane signaling receptor activity
H9J99_RS24845	COG0546	phosphoglycolate phosphatase activity
H9J99_RS24935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9J99_RS25055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9J99_RS25060	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H9J99_RS25065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9J99_RS25075	COG2207	Transcriptional regulator
H9J99_RS25080	COG1979	alcohol dehydrogenase
H9J99_RS25105	COG2271	Major facilitator Superfamily
H9J99_RS25110	COG0469	pyruvate kinase activity
H9J99_RS25115	COG1126	abc transporter atp-binding protein
H9J99_RS25120	COG0765	amino acid transport
H9J99_RS25125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9J99_RS25130	COG0765	amino acid transport
H9J99_RS25135	COG2200	EAL domain
H9J99_RS25135	COG2199	diguanylate cyclase activity
H9J99_RS25135	COG2203	Gaf domain
H9J99_RS25150	COG1609	Transcriptional regulator
H9J99_RS25155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9J99_RS25155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9J99_RS25160	COG1105	Belongs to the carbohydrate kinase PfkB family
H9J99_RS25165	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H9J99_RS25165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9J99_RS25165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9J99_RS25205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9J99_RS25210	COG0509	glycine decarboxylation via glycine cleavage system
H9J99_RS25215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9J99_RS25215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9J99_RS25220	COG2204	response regulator
H9J99_RS25240	COG1278	Cold shock
H9J99_RS25270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9J99_RS25275	COG0583	DNA-binding transcription factor activity
H9J99_RS25280	COG2176	DNA-directed DNA polymerase activity
H9J99_RS25320	COG0242	peptide deformylase activity
H9J99_RS25340	COG2239	Acts as a magnesium transporter
H9J99_RS25360	COG0346	lactoylglutathione lyase activity
H9J99_RS25365	COG1902	pentaerythritol trinitrate reductase activity
H9J99_RS25385	COG5642	Protein of unknown function (DUF2384)
H9J99_RS25390	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9J99_RS25405	COG4565	transcriptional regulatory protein
H9J99_RS25410	COG3290	protein histidine kinase activity
H9J99_RS25415	COG0471	metal ion transport
H9J99_RS25445	COG2076	Multidrug Resistance protein
H9J99_RS25460	COG0671	phosphoesterase, PA-phosphatase related
H9J99_RS25470	COG2962	Rard protein
H9J99_RS25485	COG0784	Response regulator, receiver
H9J99_RS25485	COG0835	chemotaxis
H9J99_RS25505	COG2197	response regulator
H9J99_RS25515	COG3706	GGDEF domain
H9J99_RS25520	COG2197	response regulator
H9J99_RS25575	COG5492	domain, Protein
H9J99_RS25575	COG4932	domain protein
H9J99_RS25735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9J99_RS25845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9J99_RS25875	COG2948	multi-organism process
H9J99_RS25895	COG3701	Conjugal transfer protein
H9J99_RS25905	COG4962	Type ii secretion system protein e
H9J99_RS25915	COG3451	type IV secretory pathway VirB4
H9J99_RS25920	COG5268	conjugation
H9J99_RS26255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9J99_RS26355	COG4974	Belongs to the 'phage' integrase family
H9J99_RS26460	COG1475	DNA binding