locus-tag	class	description
vsple_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
vsple_RS00010	COG0592	DNA-directed DNA polymerase activity
vsple_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
vsple_RS00020	COG0187	DNA topoisomerase II activity
vsple_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
vsple_RS00030	COG3977	Valine--pyruvate aminotransferase
vsple_RS00035	COG0366	Alpha amylase catalytic
vsple_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
vsple_RS00050	COG2119	membrane
vsple_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
vsple_RS00075	COG0604	alcohol dehydrogenase
vsple_RS00080	COG0183	Belongs to the thiolase family
vsple_RS00085	COG1024	Enoyl-CoA hydratase
vsple_RS00085	COG1250	3-hydroxyacyl-CoA dehydrogenase
vsple_RS00090	COG1739	Uncharacterized protein family UPF0029
vsple_RS00095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
vsple_RS00160	COG0583	DNA-binding transcription factor activity
vsple_RS00165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
vsple_RS00170	COG2960	long-chain fatty acid transporting porin activity
vsple_RS00175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vsple_RS00180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vsple_RS00185	COG1309	transcriptional regulator
vsple_RS00235	COG0601	transmembrane transport
vsple_RS00240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vsple_RS00285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
vsple_RS00290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
vsple_RS00295	COG0339	signal peptide processing
vsple_RS00300	COG1522	sequence-specific DNA binding
vsple_RS00305	COG5002	protein histidine kinase activity
vsple_RS00305	COG5001	Diguanylate cyclase
vsple_RS00310	COG0742	ribosomal rna small subunit methyltransferase
vsple_RS00325	COG0589	response to stress
vsple_RS00330	COG1528	Iron-storage protein
vsple_RS00340	COG2081	HI0933 family
vsple_RS00350	COG1322	Protein conserved in bacteria
vsple_RS00355	COG2226	methyltransferase
vsple_RS00360	COG3165	ubiquinone biosynthetic process from chorismate
vsple_RS00365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
vsple_RS00370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
vsple_RS00375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
vsple_RS00380	COG0805	protein transport
vsple_RS00385	COG0084	hydrolase, TatD family'
vsple_RS00395	COG0456	acetyltransferase
vsple_RS00400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vsple_RS00400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vsple_RS00425	COG3078	GTPase activator activity
vsple_RS00450	COG3852	Histidine kinase
vsple_RS00460	COG0174	glutamine synthetase
vsple_RS00465	COG1217	gtp-binding protein TYPA
vsple_RS00480	COG1295	ribonuclease BN
vsple_RS00485	COG1490	D-aminoacyl-tRNA deacylase activity
vsple_RS00490	COG0456	acetyltransferase
vsple_RS00500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
vsple_RS00510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
vsple_RS00515	COG3031	protein transport across the cell outer membrane
vsple_RS00525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
vsple_RS00530	COG1459	type II secretion system
vsple_RS00535	COG2165	general secretion pathway protein
vsple_RS00540	COG2165	general secretion pathway protein
vsple_RS00545	COG2165	general secretion pathway protein
vsple_RS00550	COG4795	General secretion pathway protein
vsple_RS00555	COG3156	type II secretion system protein K
vsple_RS00560	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
vsple_RS00565	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
vsple_RS00580	COG1218	3'(2'),5'-bisphosphate nucleotidase
vsple_RS00585	COG0494	nUDIX hydrolase
vsple_RS00590	COG0316	Belongs to the HesB IscA family
vsple_RS00590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
vsple_RS00595	COG1040	competence protein
vsple_RS00600	COG0596	Alpha beta hydrolase
vsple_RS00610	COG2183	response to ionizing radiation
vsple_RS00615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
vsple_RS00630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
vsple_RS00635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
vsple_RS00640	COG1758	RNA polymerase activity
vsple_RS00645	COG0194	GDP metabolic process
vsple_RS00650	COG2252	PERMEase
vsple_RS00675	COG1561	YicC-like family, N-terminal region
vsple_RS00680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
vsple_RS00685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
vsple_RS00690	COG1560	Kdo2-lipid A biosynthetic process
vsple_RS00695	COG1309	transcriptional regulator
vsple_RS00700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
vsple_RS00710	COG2003	Belongs to the UPF0758 family
vsple_RS00715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
vsple_RS00720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
vsple_RS00735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
vsple_RS00745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
vsple_RS00750	COG0438	transferase activity, transferring glycosyl groups
vsple_RS00755	COG0463	Glycosyl transferase, family 2
vsple_RS00760	COG0859	PFAM glycosyl transferase family 9
vsple_RS00765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
vsple_RS00770	COG3642	lipopolysaccharide core region biosynthetic process
vsple_RS00775	COG3083	sulfuric ester hydrolase activity
vsple_RS00785	COG1086	Polysaccharide biosynthesis protein
vsple_RS00790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
vsple_RS00800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
vsple_RS00805	COG0107	imidazoleglycerol-phosphate synthase activity
vsple_RS00810	COG1083	cytidylyl-transferase
vsple_RS00820	COG2089	acid synthase
vsple_RS00830	COG1519	Transferase
vsple_RS00835	COG0859	PFAM glycosyl transferase family 9
vsple_RS00840	COG1560	Kdo2-lipid A biosynthetic process
vsple_RS00855	COG4942	peptidase
vsple_RS00860	COG1045	serine acetyltransferase
vsple_RS00870	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
vsple_RS00875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
vsple_RS00895	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vsple_RS00900	COG1596	polysaccharide export
vsple_RS00910	COG3206	protein involved in exopolysaccharide biosynthesis
vsple_RS00910	COG0489	protein tyrosine kinase activity
vsple_RS00945	COG5433	transposase activity
vsple_RS00960	COG1028	Short-chain dehydrogenase reductase Sdr
vsple_RS00965	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
vsple_RS00975	COG1216	Glycosyl transferase, family 2
vsple_RS00995	COG1215	transferase activity, transferring glycosyl groups
vsple_RS01050	COG1879	ABC-type sugar transport system periplasmic component
vsple_RS01055	COG1172	Belongs to the binding-protein-dependent transport system permease family
vsple_RS01060	COG1129	ABC transporter
vsple_RS01065	COG1070	Carbohydrate kinase
vsple_RS01075	COG1609	Transcriptional regulator
vsple_RS01080	COG1917	Cupin 2, conserved barrel domain protein
vsple_RS01090	COG1349	DNA-binding transcription factor activity
vsple_RS01100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
vsple_RS01105	COG0738	Major facilitator superfamily
vsple_RS01165	COG4251	negative regulation of phosphorylation
vsple_RS01170	COG2197	response regulator
vsple_RS01175	COG3300	MHYT domain
vsple_RS01175	COG5001	Diguanylate cyclase
vsple_RS01180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
vsple_RS01185	COG0534	Mate efflux family protein
vsple_RS01190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
vsple_RS01195	COG0459	protein refolding
vsple_RS01205	COG1285	pathogenesis
vsple_RS01210	COG1509	lysine 2,3-aminomutase activity
vsple_RS01215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
vsple_RS01230	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
vsple_RS01235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
vsple_RS01240	COG1053	succinate dehydrogenase
vsple_RS01245	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
vsple_RS01255	COG0490	domain, Protein
vsple_RS01255	COG0471	metal ion transport
vsple_RS01260	COG0688	phosphatidylethanolamine metabolic process
vsple_RS01265	COG1162	GTPase activity
vsple_RS01350	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
vsple_RS01355	COG0802	atpase or kinase
vsple_RS01365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
vsple_RS01370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
vsple_RS01375	COG1923	regulation of RNA biosynthetic process
vsple_RS01380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
vsple_RS01385	COG0330	HflC and HflK could
vsple_RS01390	COG0330	HflC and HflK could
vsple_RS01395	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
vsple_RS01400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
vsple_RS01405	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
vsple_RS01410	COG0402	S-adenosylhomocysteine deaminase activity
vsple_RS01415	COG0557	exoribonuclease II activity
vsple_RS01420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
vsple_RS01435	COG0359	binds to the 23S rRNA
vsple_RS01450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
vsple_RS01460	COG0432	Pfam Uncharacterised protein family UPF0047
vsple_RS01465	COG0166	Belongs to the GPI family
vsple_RS01475	COG0735	belongs to the Fur family
vsple_RS01500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
vsple_RS01505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
vsple_RS01510	COG0175	sulfate reduction
vsple_RS01605	COG0646	methionine synthase
vsple_RS01605	COG1410	methionine synthase
vsple_RS01610	COG0527	aspartate kinase activity
vsple_RS01615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
vsple_RS01625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
vsple_RS01655	COG2197	response regulator
vsple_RS01660	COG0629	single-stranded DNA binding
vsple_RS01665	COG2199	diguanylate cyclase activity
vsple_RS01665	COG2200	EAL domain
vsple_RS01690	COG3409	Peptidoglycan-binding domain 1 protein
vsple_RS01690	COG3267	Type II secretory pathway component ExeA
vsple_RS01700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
vsple_RS01705	COG1459	type II secretion system
vsple_RS01715	COG2165	general secretion pathway protein
vsple_RS01750	COG1077	Cell shape determining protein MreB Mrl
vsple_RS01755	COG1792	Involved in formation and maintenance of cell shape
vsple_RS01760	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
vsple_RS01765	COG0424	maF-like protein
vsple_RS01780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
vsple_RS01785	COG0312	modulator of DNA gyrase
vsple_RS01790	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
vsple_RS01795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
vsple_RS01805	COG0564	pseudouridine synthase activity
vsple_RS01810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
vsple_RS01815	COG0589	response to stress
vsple_RS01825	COG2358	TRAP transporter, solute receptor (TAXI family
vsple_RS01830	COG1438	arginine binding
vsple_RS01835	COG0039	L-malate dehydrogenase activity
vsple_RS01845	COG0142	geranyltranstransferase activity
vsple_RS01850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
vsple_RS01855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
vsple_RS01860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
vsple_RS01865	COG2966	Psort location CytoplasmicMembrane, score
vsple_RS01870	COG3610	response to peptide
vsple_RS01885	COG2967	ApaG domain
vsple_RS01890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
vsple_RS01895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
vsple_RS01900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
vsple_RS01905	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
vsple_RS01910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
vsple_RS01935	COG0473	3-isopropylmalate dehydrogenase activity
vsple_RS01940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
vsple_RS01975	COG1022	Amp-dependent synthetase and ligase
vsple_RS01980	COG0028	Belongs to the TPP enzyme family
vsple_RS01990	COG3706	GGDEF domain
vsple_RS01995	COG1802	Transcriptional regulator
vsple_RS02000	COG0469	pyruvate kinase activity
vsple_RS02005	COG1349	DNA-binding transcription factor activity
vsple_RS02010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
vsple_RS02015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
vsple_RS02020	COG2873	o-acetylhomoserine
vsple_RS02045	COG1610	YqeY-like protein
vsple_RS02050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
vsple_RS02055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
vsple_RS02060	COG0596	Alpha beta hydrolase
vsple_RS02065	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
vsple_RS02070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
vsple_RS02080	COG1968	undecaprenyl-diphosphatase activity
vsple_RS02085	COG0617	tRNA 3'-terminal CCA addition
vsple_RS02090	COG3409	Peptidoglycan-binding domain 1 protein
vsple_RS02090	COG3267	Type II secretory pathway component ExeA
vsple_RS02100	COG4991	sh3 domain protein
vsple_RS02105	COG0306	phosphate transporter
vsple_RS02110	COG1392	Phosphate transport regulator
vsple_RS02115	COG3025	triphosphatase activity
vsple_RS02120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
vsple_RS02130	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
vsple_RS02135	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
vsple_RS02135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
vsple_RS02140	COG1538	Outer membrane efflux protein
vsple_RS02145	COG0494	nUDIX hydrolase
vsple_RS02150	COG3151	Protein conserved in bacteria
vsple_RS02160	COG3150	esterase
vsple_RS02175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
vsple_RS02185	COG3105	Protein conserved in bacteria
vsple_RS02190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
vsple_RS02200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
vsple_RS02205	COG0723	plastoquinol--plastocyanin reductase activity
vsple_RS02210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
vsple_RS02215	COG2857	Cytochrome c1
vsple_RS02220	COG0625	glutathione transferase activity
vsple_RS02225	COG2969	positive regulation of protein catabolic process
vsple_RS02235	COG2823	Periplasmic or secreted lipoprotein
vsple_RS02240	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
vsple_RS02255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
vsple_RS02265	COG0275	rRNA processing
vsple_RS02270	COG3116	cell division
vsple_RS02275	COG0768	penicillin binding
vsple_RS02280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
vsple_RS02285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
vsple_RS02290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
vsple_RS02295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
vsple_RS02300	COG0772	Belongs to the SEDS family
vsple_RS02305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
vsple_RS02310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
vsple_RS02315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
vsple_RS02320	COG0849	cell division
vsple_RS02325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
vsple_RS02330	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
vsple_RS02335	COG0653	protein targeting
vsple_RS02340	COG0494	nUDIX hydrolase
vsple_RS02345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
vsple_RS02350	COG0505	Belongs to the CarA family
vsple_RS02355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
vsple_RS02360	COG0730	response to heat
vsple_RS02365	COG0583	DNA-binding transcription factor activity
vsple_RS02370	COG0655	NAD(P)H dehydrogenase (quinone) activity
vsple_RS02380	COG2860	membrane
vsple_RS02385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
vsple_RS02395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
vsple_RS02405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
vsple_RS02410	COG0067	glutamate synthase
vsple_RS02410	COG0070	glutamate synthase
vsple_RS02410	COG0069	glutamate synthase activity
vsple_RS02420	COG0070	glutamate synthase
vsple_RS02420	COG0069	glutamate synthase activity
vsple_RS02420	COG0067	glutamate synthase
vsple_RS02425	COG1242	4 iron, 4 sulfur cluster binding
vsple_RS02430	COG3706	GGDEF domain
vsple_RS02430	COG2203	Gaf domain
vsple_RS02430	COG5001	Diguanylate cyclase
vsple_RS02430	COG4251	negative regulation of phosphorylation
vsple_RS02435	COG0784	Response regulator, receiver
vsple_RS02435	COG5002	protein histidine kinase activity
vsple_RS02435	COG2198	Histidine kinase
vsple_RS02445	COG0745	RESPONSE REGULATOR receiver
vsple_RS02450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
vsple_RS02465	COG0083	homoserine kinase activity
vsple_RS02470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
vsple_RS02475	COG0431	NADPH-dependent FMN reductase
vsple_RS02480	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
vsple_RS02505	COG1115	amino acid carrier protein
vsple_RS02510	COG3022	response to hydroperoxide
vsple_RS02515	COG0513	Belongs to the DEAD box helicase family
vsple_RS02520	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
vsple_RS02530	COG0716	FMN binding
vsple_RS02535	COG4974	Belongs to the 'phage' integrase family
vsple_RS02540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
vsple_RS02545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
vsple_RS02555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
vsple_RS02560	COG2204	response regulator
vsple_RS02585	COG0494	nUDIX hydrolase
vsple_RS02595	COG0730	response to heat
vsple_RS02600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
vsple_RS02605	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
vsple_RS02610	COG1283	sodium-dependent phosphate transmembrane transporter activity
vsple_RS02615	COG0583	DNA-binding transcription factor activity
vsple_RS02620	COG0640	Transcriptional regulator
vsple_RS02625	COG0268	Binds directly to 16S ribosomal RNA
vsple_RS02630	COG0728	peptidoglycan biosynthetic process
vsple_RS02635	COG0196	riboflavin kinase activity
vsple_RS02640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
vsple_RS02650	COG1047	Peptidyl-prolyl cis-trans
vsple_RS02655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
vsple_RS02660	COG3279	Response regulator of the LytR AlgR family
vsple_RS02665	COG3275	phosphorelay sensor kinase activity
vsple_RS02670	COG1966	Carbon starvation protein
vsple_RS02680	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
vsple_RS02685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
vsple_RS02695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
vsple_RS02700	COG1605	Chorismate mutase
vsple_RS02700	COG0287	Prephenate dehydrogenase
vsple_RS02705	COG0739	heme binding
vsple_RS02715	COG0488	(ABC) transporter
vsple_RS02725	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
vsple_RS02730	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
vsple_RS02735	COG1605	Chorismate mutase
vsple_RS02735	COG0077	Prephenate dehydratase
vsple_RS02740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
vsple_RS02745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vsple_RS02750	COG0564	pseudouridine synthase activity
vsple_RS02795	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
vsple_RS02805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
vsple_RS02810	COG0826	peptidase U32
vsple_RS02815	COG2974	May be involved in recombination
vsple_RS02820	COG0745	RESPONSE REGULATOR receiver
vsple_RS02825	COG5002	protein histidine kinase activity
vsple_RS02835	COG0248	Ppx GppA phosphatase
vsple_RS02840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
vsple_RS02850	COG0581	inorganic phosphate transmembrane transporter activity
vsple_RS02855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
vsple_RS02860	COG0704	Plays a role in the regulation of phosphate uptake
vsple_RS02865	COG3142	Participates in the control of copper homeostasis
vsple_RS02870	COG0450	alkyl hydroperoxide reductase
vsple_RS02875	COG0583	DNA-binding transcription factor activity
vsple_RS02880	COG0517	IMP dehydrogenase activity
vsple_RS02885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
vsple_RS02890	COG0343	queuine tRNA-ribosyltransferase activity
vsple_RS02895	COG1862	Preprotein translocase
vsple_RS02900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
vsple_RS02905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
vsple_RS02910	COG0483	inositol monophosphate 1-phosphatase activity
vsple_RS02915	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
vsple_RS02920	COG1959	2 iron, 2 sulfur cluster binding
vsple_RS02925	COG1104	cysteine desulfurase activity
vsple_RS02930	COG0822	iron-sulfur transferase activity
vsple_RS02945	COG0443	Heat shock 70 kDa protein
vsple_RS02955	COG2975	iron-sulfur cluster assembly
vsple_RS02960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
vsple_RS02965	COG0105	UTP biosynthetic process
vsple_RS02970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
vsple_RS02980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
vsple_RS02985	COG0124	histidyl-tRNA synthetase
vsple_RS02990	COG2976	Protein conserved in bacteria
vsple_RS02995	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vsple_RS03000	COG1160	GTP binding
vsple_RS03045	COG0831	urea catabolic process
vsple_RS03050	COG0832	Belongs to the urease beta subunit family
vsple_RS03055	COG0804	urea catabolic process
vsple_RS03060	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
vsple_RS03070	COG0830	nickel cation binding
vsple_RS03075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
vsple_RS03080	COG1570	exodeoxyribonuclease VII activity
vsple_RS03085	COG0516	GMP reductase activity
vsple_RS03085	COG0517	IMP dehydrogenase activity
vsple_RS03090	COG0519	Catalyzes the synthesis of GMP from XMP
vsple_RS03090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
vsple_RS03095	COG1584	GPR1 FUN34 yaaH family protein
vsple_RS03100	COG1115	amino acid carrier protein
vsple_RS03105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
vsple_RS03110	COG0204	Acyl-transferase
vsple_RS03150	COG1104	cysteine desulfurase activity
vsple_RS03195	COG3550	peptidyl-serine autophosphorylation
vsple_RS03200	COG1396	sequence-specific DNA binding
vsple_RS03225	COG2867	negative regulation of translational initiation
vsple_RS03230	COG2914	Belongs to the UPF0125 (RnfH) family
vsple_RS03235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vsple_RS03240	COG0497	DNA recombination
vsple_RS03245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
vsple_RS03250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
vsple_RS03255	COG1301	dicarboxylic acid transport
vsple_RS03265	COG0443	Heat shock 70 kDa protein
vsple_RS03270	COG0484	heat shock protein binding
vsple_RS03300	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
vsple_RS03320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
vsple_RS03320	COG0047	phosphoribosylformylglycinamidine synthase activity
vsple_RS03325	COG2171	N-acyltransferase activity
vsple_RS03340	COG3141	response to X-ray
vsple_RS03350	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
vsple_RS03355	COG1074	ATP-dependent DNA helicase activity
vsple_RS03370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
vsple_RS03370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
vsple_RS03380	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
vsple_RS03385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
vsple_RS03390	COG2166	iron-sulfur cluster assembly
vsple_RS03395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
vsple_RS03400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
vsple_RS03405	COG3248	Nucleoside-binding outer membrane protein
vsple_RS03415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
vsple_RS03425	COG2813	Specifically methylates the guanine in position
vsple_RS03430	COG0271	Belongs to the BolA IbaG family
vsple_RS03435	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vsple_RS03440	COG1805	sodium ion transport
vsple_RS03450	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vsple_RS03455	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vsple_RS03460	COG2871	sodium ion transport
vsple_RS03465	COG1477	protein flavinylation
vsple_RS03470	COG2991	Protein conserved in bacteria
vsple_RS03480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
vsple_RS03485	COG0514	ATP-dependent DNA helicase (RecQ)
vsple_RS03490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
vsple_RS03500	COG0733	neurotransmitter:sodium symporter activity
vsple_RS03505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
vsple_RS03510	COG0321	lipoyl(octanoyl) transferase activity
vsple_RS03520	COG1686	Belongs to the peptidase S11 family
vsple_RS03525	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
vsple_RS03530	COG0772	Belongs to the SEDS family
vsple_RS03535	COG0768	penicillin binding
vsple_RS03545	COG0799	negative regulation of ribosome biogenesis
vsple_RS03550	COG1466	dna polymerase III delta subunit
vsple_RS03555	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
vsple_RS03560	COG0495	leucyl-tRNA aminoacylation
vsple_RS03565	COG2888	peptidyl-tyrosine sulfation
vsple_RS03570	COG0815	Transfers the fatty acyl group on membrane lipoproteins
vsple_RS03575	COG4535	Mg2 and Co2 transporter CorC
vsple_RS03580	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
vsple_RS03585	COG1702	phosphate starvation-inducible protein PhoH
vsple_RS03590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
vsple_RS03595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
vsple_RS03600	COG2706	6-phosphogluconolactonase activity
vsple_RS03705	COG0012	GTP binding
vsple_RS03710	COG0193	aminoacyl-tRNA hydrolase activity
vsple_RS03715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
vsple_RS03720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
vsple_RS03725	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
vsple_RS03730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
vsple_RS03735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
vsple_RS03740	COG2890	protein-(glutamine-N5) methyltransferase activity
vsple_RS03750	COG2912	Transglutaminase-like superfamily
vsple_RS03755	COG2877	3-deoxy-8-phosphooctulonate synthase activity
vsple_RS03765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
vsple_RS03770	COG1187	pseudouridine synthase activity
vsple_RS03775	COG2840	Smr protein MutS2
vsple_RS03810	COG2217	Heavy metal translocating P-type atpase
vsple_RS03810	COG2608	mercury ion transmembrane transporter activity
vsple_RS03830	COG1028	Short-chain dehydrogenase reductase Sdr
vsple_RS03840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
vsple_RS03865	COG2986	histidine ammonia-lyase
vsple_RS03870	COG1216	Glycosyl transferase, family 2
vsple_RS03890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
vsple_RS03960	COG0784	Response regulator, receiver
vsple_RS03960	COG0835	chemotaxis
vsple_RS03965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
vsple_RS03970	COG1815	bacterial-type flagellum-dependent cell motility
vsple_RS03990	COG4787	bacterial-type flagellum-dependent cell motility
vsple_RS04000	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
vsple_RS04005	COG1706	bacterial-type flagellum-dependent cell motility
vsple_RS04010	COG1705	Flagellar rod assembly protein muramidase FlgJ
vsple_RS04010	COG3951	Flagellar rod assembly protein muramidase FlgJ
vsple_RS04030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vsple_RS04035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vsple_RS04040	COG1334	flagellar protein FlaG
vsple_RS04045	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
vsple_RS04055	COG1516	flagellar protein fliS
vsple_RS04075	COG1677	Flagellar hook-basal body complex protein FliE
vsple_RS04085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
vsple_RS04135	COG1987	bacterial-type flagellum assembly
vsple_RS04140	COG1684	flagellar biosynthetic protein fliR
vsple_RS04175	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
vsple_RS04180	COG2198	Histidine kinase
vsple_RS04180	COG0784	Response regulator, receiver
vsple_RS04180	COG0643	Histidine kinase
vsple_RS04185	COG2201	protein-glutamate methylesterase activity
vsple_RS04190	COG1192	Involved in chromosome partitioning
vsple_RS04200	COG0835	chemotaxis
vsple_RS04210	COG4133	protoheme IX ABC transporter activity
vsple_RS04215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
vsple_RS04220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
vsple_RS04225	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
vsple_RS04230	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
vsple_RS04235	COG1138	Cytochrome C-type biogenesis protein
vsple_RS04240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
vsple_RS04245	COG4235	cytochrome complex assembly
vsple_RS04245	COG3088	subunit of a heme lyase
vsple_RS04255	COG2853	Lipoprotein
vsple_RS04260	COG2067	long-chain fatty acid transport protein
vsple_RS04265	COG2067	long-chain fatty acid transport protein
vsple_RS04280	COG0183	Belongs to the thiolase family
vsple_RS04285	COG1024	Enoyl-CoA hydratase
vsple_RS04285	COG1250	3-hydroxyacyl-CoA dehydrogenase
vsple_RS04290	COG1025	Belongs to the peptidase M16 family
vsple_RS04295	COG2062	phosphohistidine phosphatase, SixA
vsple_RS04300	COG2840	Smr protein MutS2
vsple_RS04305	COG2890	protein-(glutamine-N5) methyltransferase activity
vsple_RS04310	COG1280	lysine exporter protein (LysE YggA)
vsple_RS04315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
vsple_RS04335	COG1175	transmembrane transport
vsple_RS04345	COG3842	ATPase activity
vsple_RS04350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
vsple_RS04355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
vsple_RS04360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
vsple_RS04370	COG2204	response regulator
vsple_RS04380	COG0544	peptidyl-prolyl cis-trans isomerase activity
vsple_RS04385	COG0740	serine-type endopeptidase activity
vsple_RS04390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
vsple_RS04395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
vsple_RS04400	COG0776	regulation of translation
vsple_RS04405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
vsple_RS04410	COG1555	photosystem II stabilization
vsple_RS04425	COG0232	Belongs to the dGTPase family. Type 2 subfamily
vsple_RS04430	COG0189	ligase activity
vsple_RS04445	COG2239	Acts as a magnesium transporter
vsple_RS04475	COG3655	Transcriptional regulator
vsple_RS04480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
vsple_RS04485	COG0459	protein refolding
vsple_RS04490	COG0071	Belongs to the small heat shock protein (HSP20) family
vsple_RS04495	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
vsple_RS04500	COG0436	Aminotransferase
vsple_RS04505	COG1169	isochorismate synthase
vsple_RS04510	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
vsple_RS04540	COG2855	membrane
vsple_RS04545	COG0477	Major facilitator Superfamily
vsple_RS04590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vsple_RS04595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vsple_RS04605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
vsple_RS04610	COG1522	sequence-specific DNA binding
vsple_RS04615	COG1946	Acyl-CoA thioesterase
vsple_RS04620	COG3126	Type III secretion system lipoprotein chaperone (YscW)
vsple_RS04690	COG3708	Transcriptional regulator
vsple_RS04690	COG2207	Transcriptional regulator
vsple_RS04700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
vsple_RS04725	COG0583	DNA-binding transcription factor activity
vsple_RS04760	COG3344	reverse transcriptase
vsple_RS04790	COG2203	Gaf domain
vsple_RS04790	COG3706	GGDEF domain
vsple_RS04790	COG4251	negative regulation of phosphorylation
vsple_RS04790	COG5001	Diguanylate cyclase
vsple_RS04815	COG2824	Alkylphosphonate utilization operon protein PhnA
vsple_RS04830	COG5002	protein histidine kinase activity
vsple_RS04830	COG3850	Histidine kinase
vsple_RS04835	COG0745	RESPONSE REGULATOR receiver
vsple_RS04870	COG1609	Transcriptional regulator
vsple_RS04885	COG2814	Major facilitator Superfamily
vsple_RS04895	COG1760	l-serine dehydratase
vsple_RS04900	COG1522	sequence-specific DNA binding
vsple_RS04910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
vsple_RS04915	COG1574	metal-dependent hydrolase with the TIM-barrel fold
vsple_RS04920	COG3040	lipid binding
vsple_RS04940	COG0346	lactoylglutathione lyase activity
vsple_RS04945	COG1902	pentaerythritol trinitrate reductase activity
vsple_RS04955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
vsple_RS04960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
vsple_RS04970	COG0517	IMP dehydrogenase activity
vsple_RS04970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
vsple_RS04970	COG0617	tRNA 3'-terminal CCA addition
vsple_RS04975	COG2217	Heavy metal translocating P-type atpase
vsple_RS04995	COG0537	adenosine 5'-monophosphoramidase activity
vsple_RS05020	COG3150	esterase
vsple_RS05025	COG1252	NADH dehydrogenase
vsple_RS05030	COG1028	Short-chain dehydrogenase reductase Sdr
vsple_RS05035	COG0616	signal peptide processing
vsple_RS05040	COG2719	SpoVR family
vsple_RS05045	COG2718	Belongs to the UPF0229 family
vsple_RS05050	COG2766	serine protein kinase
vsple_RS05055	COG3013	Belongs to the UPF0304 family
vsple_RS05060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
vsple_RS05070	COG1882	Formate acetyltransferase
vsple_RS05100	COG4160	amino acid transport
vsple_RS05115	COG0840	transmembrane signaling receptor activity
vsple_RS05120	COG2850	peptidyl-arginine hydroxylation
vsple_RS05135	COG0730	response to heat
vsple_RS05140	COG1199	ATP-dependent helicase activity
vsple_RS05150	COG1187	pseudouridine synthase activity
vsple_RS05160	COG1278	Cold shock
vsple_RS05165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
vsple_RS05170	COG0542	response to heat
vsple_RS05175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
vsple_RS05180	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
vsple_RS05185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
vsple_RS05195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
vsple_RS05205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
vsple_RS05210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
vsple_RS05215	COG0297	glycogen (starch) synthase activity
vsple_RS05235	COG3070	regulator of competence-specific genes
vsple_RS05240	COG1609	Transcriptional regulator
vsple_RS05245	COG3381	protein complex oligomerization
vsple_RS05250	COG0745	RESPONSE REGULATOR receiver
vsple_RS05255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
vsple_RS05260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
vsple_RS05265	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
vsple_RS05270	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
vsple_RS05275	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
vsple_RS05280	COG3383	formate dehydrogenase (NAD+) activity
vsple_RS05295	COG0189	ligase activity
vsple_RS05295	COG4067	protein conserved in archaea
vsple_RS05300	COG0500	methyltransferase
vsple_RS05305	COG4106	trans-aconitate 2-methyltransferase activity
vsple_RS05310	COG1801	Protein of unknown function DUF72
vsple_RS05325	COG0840	transmembrane signaling receptor activity
vsple_RS05330	COG0632	four-way junction helicase activity
vsple_RS05335	COG2255	four-way junction helicase activity
vsple_RS05340	COG1271	oxidase subunit
vsple_RS05345	COG1294	oxidase, subunit
vsple_RS05350	COG4890	Cyd operon protein YbgT
vsple_RS05360	COG0824	Thioesterase
vsple_RS05365	COG0811	peptide transport
vsple_RS05380	COG0823	Involved in the tonB-independent uptake of proteins
vsple_RS05385	COG2885	chlorophyll binding
vsple_RS05390	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
vsple_RS05395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
vsple_RS05410	COG0784	Response regulator, receiver
vsple_RS05410	COG5002	protein histidine kinase activity
vsple_RS05430	COG4932	domain protein
vsple_RS05430	COG5492	domain, Protein
vsple_RS05440	COG3119	arylsulfatase activity
vsple_RS05445	COG0641	radical SAM
vsple_RS05450	COG0714	Associated with various cellular activities
vsple_RS05480	COG2199	diguanylate cyclase activity
vsple_RS05490	COG0583	DNA-binding transcription factor activity
vsple_RS05500	COG0584	glycerophosphoryl diester phosphodiesterase
vsple_RS05515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
vsple_RS05560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
vsple_RS05575	COG0745	RESPONSE REGULATOR receiver
vsple_RS05580	COG0463	Glycosyl transferase, family 2
vsple_RS05595	COG1032	radical SAM domain protein
vsple_RS05615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
vsple_RS05625	COG2350	Protein conserved in bacteria
vsple_RS05630	COG1607	acyl-coa hydrolase
vsple_RS05635	COG2917	probably involved in intracellular septation
vsple_RS05650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
vsple_RS05655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vsple_RS05665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
vsple_RS05675	COG1301	dicarboxylic acid transport
vsple_RS05680	COG0159	tryptophan synthase activity
vsple_RS05690	COG0134	indole-3-glycerol-phosphate synthase activity
vsple_RS05690	COG0135	phosphoribosylanthranilate isomerase activity
vsple_RS05695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
vsple_RS05700	COG0512	Glutamine amidotransferase of anthranilate synthase
vsple_RS05705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
vsple_RS05715	COG0613	PHP domain protein
vsple_RS05720	COG0009	L-threonylcarbamoyladenylate synthase
vsple_RS05725	COG1187	pseudouridine synthase activity
vsple_RS05740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
vsple_RS05750	COG0417	DNA replication proofreading
vsple_RS05755	COG2197	response regulator
vsple_RS05760	COG0322	excinuclease ABC activity
vsple_RS05800	COG0019	diaminopimelate decarboxylase activity
vsple_RS05835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
vsple_RS05840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
vsple_RS05845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
vsple_RS05860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
vsple_RS05865	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
vsple_RS05875	COG0437	4 iron, 4 sulfur cluster binding
vsple_RS05880	COG3301	Polysulphide reductase, NrfD
vsple_RS05885	COG1138	Cytochrome C-type biogenesis protein
vsple_RS05895	COG3088	subunit of a heme lyase
vsple_RS05895	COG4235	cytochrome complex assembly
vsple_RS05905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
vsple_RS05930	COG2989	Protein conserved in bacteria
vsple_RS05935	COG3108	Peptidase M15
vsple_RS05940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
vsple_RS05955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
vsple_RS05980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
vsple_RS05990	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
vsple_RS05995	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
vsple_RS06000	COG4988	ABC transporter
vsple_RS06005	COG0492	ferredoxin-NADP+ reductase activity
vsple_RS06015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
vsple_RS06035	COG0471	metal ion transport
vsple_RS06040	COG2949	membrane
vsple_RS06045	COG0281	malic enzyme
vsple_RS06060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
vsple_RS06095	COG0277	FAD linked oxidase domain protein
vsple_RS06095	COG0247	lactate metabolic process
vsple_RS06105	COG5640	endopeptidase activity
vsple_RS06115	COG2986	histidine ammonia-lyase
vsple_RS06120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
vsple_RS06125	COG0010	Belongs to the arginase family
vsple_RS06130	COG1228	amidohydrolase
vsple_RS06140	COG4326	sporulation control protein
vsple_RS06150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
vsple_RS06160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
vsple_RS06165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
vsple_RS06170	COG3097	Belongs to the UPF0267 family
vsple_RS06180	COG1309	transcriptional regulator
vsple_RS06190	COG1166	arginine decarboxylase activity
vsple_RS06205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
vsple_RS06215	COG0534	Mate efflux family protein
vsple_RS06220	COG0444	Belongs to the ABC transporter superfamily
vsple_RS06225	COG4608	Belongs to the ABC transporter superfamily
vsple_RS06245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vsple_RS06245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vsple_RS06255	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
vsple_RS06260	COG1280	lysine exporter protein (LysE YggA)
vsple_RS06265	COG1115	amino acid carrier protein
vsple_RS06280	COG1115	amino acid carrier protein
vsple_RS06295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vsple_RS06310	COG3290	protein histidine kinase activity
vsple_RS06315	COG4565	transcriptional regulatory protein
vsple_RS06320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
vsple_RS06325	COG0363	glucosamine-6-phosphate deaminase activity
vsple_RS06330	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
vsple_RS06335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
vsple_RS06345	COG1132	(ABC) transporter
vsple_RS06355	COG2197	response regulator
vsple_RS06360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vsple_RS06370	COG0583	DNA-binding transcription factor activity
vsple_RS06375	COG4771	TonB-dependent receptor
vsple_RS06380	COG0454	-acetyltransferase
vsple_RS06390	COG1472	Belongs to the glycosyl hydrolase 3 family
vsple_RS06405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
vsple_RS06410	COG2176	DNA-directed DNA polymerase activity
vsple_RS06415	COG0517	IMP dehydrogenase activity
vsple_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
vsple_RS06425	COG1917	Cupin 2, conserved barrel domain protein
vsple_RS06450	COG0420	3'-5' exonuclease activity
vsple_RS06455	COG0419	ATPase involved in DNA repair
vsple_RS06470	COG3046	protein related to deoxyribodipyrimidine photolyase
vsple_RS06475	COG0415	Belongs to the DNA photolyase family
vsple_RS06480	COG0589	response to stress
vsple_RS06515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
vsple_RS06530	COG1609	Transcriptional regulator
vsple_RS06540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
vsple_RS06565	COG1132	(ABC) transporter
vsple_RS06570	COG1126	abc transporter atp-binding protein
vsple_RS06575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vsple_RS06580	COG4215	(ABC) transporter
vsple_RS06585	COG4160	amino acid transport
vsple_RS06590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
vsple_RS06595	COG1215	transferase activity, transferring glycosyl groups
vsple_RS06610	COG0438	transferase activity, transferring glycosyl groups
vsple_RS06635	COG0297	glycogen (starch) synthase activity
vsple_RS06645	COG2204	response regulator
vsple_RS06655	COG3448	diguanylate cyclase activity
vsple_RS06655	COG4175	Glycine betaine
vsple_RS06660	COG4176	ABC-type proline glycine betaine transport system permease component
vsple_RS06700	COG0307	riboflavin synthase, alpha
vsple_RS06720	COG0791	NLP P60 protein
vsple_RS06735	COG3148	PFAM DTW domain containing protein
vsple_RS06740	COG1940	carbohydrate kinase activity
vsple_RS06750	COG0303	'Molybdopterin
vsple_RS06755	COG0746	molybdenum cofactor guanylyltransferase activity
vsple_RS06760	COG3842	ATPase activity
vsple_RS06765	COG4662	Binding-protein-dependent transport system inner membrane component
vsple_RS06775	COG2204	response regulator
vsple_RS06780	COG4191	Histidine kinase
vsple_RS06795	COG0840	transmembrane signaling receptor activity
vsple_RS06810	COG0488	(ABC) transporter
vsple_RS06820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
vsple_RS06850	COG0243	molybdopterin cofactor binding
vsple_RS06850	COG3383	formate dehydrogenase (NAD+) activity
vsple_RS06855	COG0437	4 iron, 4 sulfur cluster binding
vsple_RS06870	COG0004	ammonium transporteR
vsple_RS06875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
vsple_RS06880	COG3344	reverse transcriptase
vsple_RS06885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
vsple_RS06895	COG1177	transmembrane transport
vsple_RS06905	COG3842	ATPase activity
vsple_RS06925	COG0037	tRNA processing
vsple_RS06945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
vsple_RS06960	COG2217	Heavy metal translocating P-type atpase
vsple_RS06970	COG2010	Cytochrome c
vsple_RS06985	COG3278	Belongs to the heme-copper respiratory oxidase family
vsple_RS07005	COG2801	Transposase and inactivated derivatives
vsple_RS07030	COG3120	sequence-specific DNA binding
vsple_RS07035	COG1067	ATP-dependent peptidase activity
vsple_RS07055	COG0488	(ABC) transporter
vsple_RS07075	COG0167	dihydroorotate dehydrogenase activity
vsple_RS07080	COG2902	Dehydrogenase
vsple_RS07090	COG0308	aminopeptidase N
vsple_RS07105	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
vsple_RS07110	COG1956	GAF domain-containing protein
vsple_RS07115	COG1132	(ABC) transporter
vsple_RS07120	COG2995	paraquat-inducible protein a
vsple_RS07125	COG3008	intermembrane lipid transfer
vsple_RS07130	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
vsple_RS07130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
vsple_RS07135	COG2996	Protein conserved in bacteria
vsple_RS07150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
vsple_RS07155	COG1666	GTP binding
vsple_RS07165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vsple_RS07170	COG4597	amino acid ABC transporter
vsple_RS07175	COG0765	amino acid transport
vsple_RS07180	COG1126	abc transporter atp-binding protein
vsple_RS07185	COG0670	Belongs to the BI1 family
vsple_RS07190	COG2920	part of a sulfur-relay system
vsple_RS07195	COG1254	Belongs to the acylphosphatase family
vsple_RS07200	COG0840	transmembrane signaling receptor activity
vsple_RS07220	COG2885	chlorophyll binding
vsple_RS07220	COG3047	cAMP biosynthetic process
vsple_RS07235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
vsple_RS07240	COG0602	queuosine metabolic process
vsple_RS07245	COG0561	phosphatase activity
vsple_RS07265	COG2828	Protein conserved in bacteria
vsple_RS07270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
vsple_RS07275	COG0372	Belongs to the citrate synthase family
vsple_RS07280	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
vsple_RS07315	COG4628	conserved protein (DUF2132)
vsple_RS07365	COG0583	DNA-binding transcription factor activity
vsple_RS07390	COG1126	abc transporter atp-binding protein
vsple_RS07395	COG0765	amino acid transport
vsple_RS07400	COG4597	amino acid ABC transporter
vsple_RS07405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vsple_RS07410	COG0583	DNA-binding transcription factor activity
vsple_RS07420	COG0653	protein targeting
vsple_RS07425	COG0235	Class ii aldolase
vsple_RS07430	COG3395	kinase activity
vsple_RS07450	COG0473	3-isopropylmalate dehydrogenase activity
vsple_RS07465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
vsple_RS07470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
vsple_RS07475	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
vsple_RS07480	COG1609	Transcriptional regulator
vsple_RS07500	COG2199	diguanylate cyclase activity
vsple_RS07500	COG2200	EAL domain
vsple_RS07500	COG2202	Pas domain
vsple_RS07515	COG0697	spore germination
vsple_RS07520	COG0583	DNA-binding transcription factor activity
vsple_RS07525	COG4122	O-methyltransferase activity
vsple_RS07590	COG2195	Cleaves the N-terminal amino acid of tripeptides
vsple_RS07605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
vsple_RS07610	COG3063	Type IV pilus biogenesis stability protein PilW
vsple_RS07620	COG1451	nucleotide metabolic process
vsple_RS07635	COG2814	Major facilitator Superfamily
vsple_RS07650	COG1247	-acetyltransferase
vsple_RS07655	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
vsple_RS07660	COG4139	cobalamin transport
vsple_RS07665	COG2988	succinylglutamate desuccinylase activity
vsple_RS07685	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
vsple_RS07690	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
vsple_RS07695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
vsple_RS07700	COG1823	symporter activity
vsple_RS07710	COG4989	oxidoreductase activity
vsple_RS07725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
vsple_RS07730	COG3122	Protein conserved in bacteria
vsple_RS07735	COG2207	Transcriptional regulator
vsple_RS07750	COG2925	Exonuclease
vsple_RS07760	COG1346	cytolysis
vsple_RS07765	COG0295	cytidine deaminase activity
vsple_RS07770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
vsple_RS07775	COG0500	methyltransferase
vsple_RS07785	COG0776	regulation of translation
vsple_RS07795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
vsple_RS07800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
vsple_RS07805	COG1121	(ABC) transporter
vsple_RS07820	COG0583	DNA-binding transcription factor activity
vsple_RS07825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
vsple_RS07840	COG1464	Belongs to the NlpA lipoprotein family
vsple_RS07860	COG0596	Alpha beta hydrolase
vsple_RS07895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vsple_RS07895	COG0072	phenylalanine-tRNA ligase activity
vsple_RS07900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
vsple_RS07940	COG1643	Atp-dependent helicase
vsple_RS07945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
vsple_RS07975	COG3710	Transcriptional regulator
vsple_RS08015	COG0443	Heat shock 70 kDa protein
vsple_RS08020	COG0443	Heat shock 70 kDa protein
vsple_RS08035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
vsple_RS08045	COG3768	UPF0283 membrane protein
vsple_RS08050	COG3106	COG3106 Predicted ATPase
vsple_RS08065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
vsple_RS08070	COG0784	Response regulator, receiver
vsple_RS08070	COG2205	protein histidine kinase activity
vsple_RS08080	COG0494	nUDIX hydrolase
vsple_RS08085	COG0814	amino acid
vsple_RS08090	COG1760	l-serine dehydratase
vsple_RS08095	COG0814	amino acid
vsple_RS08100	COG0840	transmembrane signaling receptor activity
vsple_RS08105	COG0017	Asparaginyl-tRNA synthetase
vsple_RS08115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
vsple_RS08125	COG3437	response regulator, receiver
vsple_RS08125	COG2770	Histidine kinase
vsple_RS08130	COG1448	Aminotransferase
vsple_RS08150	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
vsple_RS08160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vsple_RS08160	COG4191	Histidine kinase
vsple_RS08175	COG3070	regulator of competence-specific genes
vsple_RS08185	COG2431	L-lysine efflux transmembrane transporter activity
vsple_RS08195	COG0076	glutamate decarboxylase activity
vsple_RS08200	COG1737	Transcriptional regulator
vsple_RS08210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
vsple_RS08215	COG2985	domain, Protein
vsple_RS08215	COG3273	potassium ion transport
vsple_RS08225	COG1960	acyl-CoA dehydrogenase activity
vsple_RS08245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
vsple_RS08260	COG4181	ATPase activity
vsple_RS08265	COG0534	Mate efflux family protein
vsple_RS08270	COG0702	epimerase
vsple_RS08280	COG2814	Major facilitator Superfamily
vsple_RS08290	COG1061	Type III restriction enzyme res subunit
vsple_RS08305	COG2205	protein histidine kinase activity
vsple_RS08315	COG0463	Glycosyl transferase, family 2
vsple_RS08315	COG1216	Glycosyl transferase, family 2
vsple_RS08320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
vsple_RS08350	COG2944	sequence-specific DNA binding
vsple_RS08355	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
vsple_RS08420	COG3547	Transposase (IS116 IS110 IS902 family)
vsple_RS08435	COG1742	UPF0060 membrane protein
vsple_RS08445	COG0384	phenazine biosynthesis protein PhzF
vsple_RS08460	COG1511	domain protein
vsple_RS08460	COG3264	Mechanosensitive ion channel
vsple_RS08470	COG0583	DNA-binding transcription factor activity
vsple_RS08490	COG4774	siderophore transport
vsple_RS08505	COG2866	Carboxypeptidase
vsple_RS08515	COG0513	Belongs to the DEAD box helicase family
vsple_RS08530	COG3313	Fe-S protein
vsple_RS08540	COG4134	Bacterial extracellular solute-binding protein
vsple_RS08545	COG4135	transport system, permease component
vsple_RS08550	COG4136	ATPase activity
vsple_RS08555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
vsple_RS08560	COG0116	Belongs to the methyltransferase superfamily
vsple_RS08560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
vsple_RS08565	COG0564	pseudouridine synthase activity
vsple_RS08570	COG0733	neurotransmitter:sodium symporter activity
vsple_RS08580	COG0626	cystathionine gamma-synthase activity
vsple_RS08585	COG2818	Glycosylase
vsple_RS08590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vsple_RS08605	COG1983	PspC domain protein
vsple_RS08615	COG1842	Phage shock protein A
vsple_RS08620	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
vsple_RS08635	COG4171	peptide transport system, permease
vsple_RS08645	COG4172	Belongs to the ABC transporter superfamily
vsple_RS08660	COG1227	inorganic diphosphatase activity
vsple_RS08670	COG0243	molybdopterin cofactor binding
vsple_RS08675	COG3005	denitrification pathway
vsple_RS08680	COG4459	periplasmic nitrate reductase
vsple_RS08685	COG0390	transport system, permease component
vsple_RS08690	COG2116	formate transmembrane transporter activity
vsple_RS08720	COG0215	cysteine-tRNA ligase activity
vsple_RS08725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
vsple_RS08730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vsple_RS08735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
vsple_RS08740	COG3012	SEC-C Motif Domain Protein
vsple_RS08745	COG0140	phosphoribosyl-ATP diphosphatase activity
vsple_RS08745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
vsple_RS08755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
vsple_RS08760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
vsple_RS08765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
vsple_RS08765	COG0131	Imidazoleglycerol-phosphate dehydratase
vsple_RS08785	COG1757	Na H antiporter
vsple_RS08790	COG2916	Histone family protein nucleoid-structuring protein H-NS
vsple_RS08795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
vsple_RS08810	COG2915	High frequency lysogenization protein hflD homolog
vsple_RS08815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
vsple_RS08820	COG0501	Belongs to the peptidase M48B family
vsple_RS08835	COG2226	methyltransferase
vsple_RS08840	COG0156	8-amino-7-oxononanoate synthase activity
vsple_RS08845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
vsple_RS08850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
vsple_RS08855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
vsple_RS08860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
vsple_RS08865	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
vsple_RS08870	COG1674	ftsk spoiiie
vsple_RS08880	COG0686	Belongs to the AlaDH PNT family
vsple_RS08890	COG0583	DNA-binding transcription factor activity
vsple_RS08915	COG4608	Belongs to the ABC transporter superfamily
vsple_RS08920	COG0444	Belongs to the ABC transporter superfamily
vsple_RS08925	COG4166	transmembrane transport
vsple_RS08930	COG4239	(ABC) transporter, permease
vsple_RS08935	COG0601	transmembrane transport
vsple_RS08940	COG0284	orotidine-5'-phosphate decarboxylase activity
vsple_RS08945	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
vsple_RS08950	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
vsple_RS08955	COG0776	regulation of translation
vsple_RS08960	COG0539	negative regulation of cytoplasmic translation
vsple_RS08965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
vsple_RS08970	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
vsple_RS08975	COG2835	tetraacyldisaccharide 4'-kinase activity
vsple_RS08980	COG1663	tetraacyldisaccharide 4'-kinase activity
vsple_RS08985	COG1132	(ABC) transporter
vsple_RS08990	COG2333	competence protein COMEC
vsple_RS08990	COG0658	competence protein
vsple_RS09000	COG4591	ABC-type transport system involved in lipoprotein release permease component
vsple_RS09005	COG1136	(ABC) transporter
vsple_RS09010	COG4591	ABC-type transport system involved in lipoprotein release permease component
vsple_RS09020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
vsple_RS09030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
vsple_RS09045	COG0587	DNA-directed DNA polymerase activity
vsple_RS09050	COG0835	chemotaxis
vsple_RS09050	COG0784	Response regulator, receiver
vsple_RS09055	COG1940	carbohydrate kinase activity
vsple_RS09060	COG0469	pyruvate kinase activity
vsple_RS09065	COG4667	esterase of the alpha-beta hydrolase superfamily
vsple_RS09080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vsple_RS09080	COG1263	PTS System
vsple_RS09085	COG0084	hydrolase, TatD family'
vsple_RS09090	COG0470	DNA polymerase III
vsple_RS09095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
vsple_RS09100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
vsple_RS09105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
vsple_RS09130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
vsple_RS09135	COG0416	fatty acid biosynthetic process
vsple_RS09140	COG0333	Belongs to the bacterial ribosomal protein bL32 family
vsple_RS09145	COG1399	metal-binding, possibly nucleic acid-binding protein
vsple_RS09150	COG0424	maF-like protein
vsple_RS09155	COG0564	pseudouridine synthase activity
vsple_RS09160	COG1530	ribonuclease E activity
vsple_RS09165	COG0659	secondary active sulfate transmembrane transporter activity
vsple_RS09175	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
vsple_RS09180	COG2982	Protein involved in outer membrane biogenesis
vsple_RS09185	COG0572	uridine kinase
vsple_RS09190	COG0489	protein tyrosine kinase activity
vsple_RS09195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vsple_RS09195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vsple_RS09205	COG2186	Transcriptional regulator
vsple_RS09210	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
vsple_RS09220	COG0653	protein targeting
vsple_RS09225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
vsple_RS09230	COG2199	diguanylate cyclase activity
vsple_RS09230	COG2203	Gaf domain
vsple_RS09235	COG0366	Alpha amylase catalytic
vsple_RS09245	COG3092	negative regulation of chromosome organization
vsple_RS09255	COG0280	phosphate acetyltransferase
vsple_RS09255	COG0857	belongs to the CobB CobQ family
vsple_RS09260	COG0435	Glutathione S-transferase
vsple_RS09270	COG0444	Belongs to the ABC transporter superfamily
vsple_RS09275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vsple_RS09280	COG0601	transmembrane transport
vsple_RS09290	COG0314	molybdopterin synthase activity
vsple_RS09295	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
vsple_RS09300	COG0315	cyclic pyranopterin monophosphate synthase activity
vsple_RS09305	COG0521	Mo-molybdopterin cofactor biosynthetic process
vsple_RS09310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
vsple_RS09315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
vsple_RS09320	COG2198	Histidine kinase
vsple_RS09325	COG2204	response regulator
vsple_RS09330	COG0556	nucleotide-excision repair
vsple_RS09340	COG4657	Part of a membrane complex involved in electron transport
vsple_RS09345	COG2878	Part of a membrane complex involved in electron transport
vsple_RS09350	COG4656	Part of a membrane complex involved in electron transport
vsple_RS09355	COG4658	electron transport chain
vsple_RS09360	COG4659	FMN binding
vsple_RS09365	COG4660	Part of a membrane complex involved in electron transport
vsple_RS09370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
vsple_RS09375	COG0346	lactoylglutathione lyase activity
vsple_RS09385	COG2885	chlorophyll binding
vsple_RS09395	COG2056	Na+-H+ antiporter family
vsple_RS09405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
vsple_RS09425	COG0840	transmembrane signaling receptor activity
vsple_RS09435	COG0583	DNA-binding transcription factor activity
vsple_RS09440	COG3706	GGDEF domain
vsple_RS09445	COG2197	response regulator
vsple_RS09455	COG0784	Response regulator, receiver
vsple_RS09455	COG2205	protein histidine kinase activity
vsple_RS09460	COG1012	belongs to the aldehyde dehydrogenase family
vsple_RS09460	COG1454	alcohol dehydrogenase
vsple_RS09465	COG2095	MarC family integral membrane protein
vsple_RS09470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
vsple_RS09475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
vsple_RS09480	COG1757	Na H antiporter
vsple_RS09490	COG3081	Nucleoid-associated protein
vsple_RS09495	COG3082	Protein of unknown function (DUF1414)
vsple_RS09500	COG3083	sulfuric ester hydrolase activity
vsple_RS09515	COG0123	including yeast histone deacetylase and acetoin utilization protein
vsple_RS09525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
vsple_RS09530	COG0778	Nitroreductase
vsple_RS09535	COG0446	pyridine nucleotide-disulphide oxidoreductase
vsple_RS09535	COG1902	pentaerythritol trinitrate reductase activity
vsple_RS09540	COG0616	signal peptide processing
vsple_RS09545	COG0252	asparaginase activity
vsple_RS09555	COG3139	Protein of unknown function (DUF1315)
vsple_RS09565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vsple_RS09580	COG2226	methyltransferase
vsple_RS09600	COG2983	Belongs to the UPF0260 family
vsple_RS09610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
vsple_RS09620	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
vsple_RS09625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
vsple_RS09630	COG2832	Protein of unknown function (DUF454)
vsple_RS09640	COG0745	RESPONSE REGULATOR receiver
vsple_RS09645	COG0583	DNA-binding transcription factor activity
vsple_RS09650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
vsple_RS09655	COG1286	toxin biosynthetic process
vsple_RS09660	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
vsple_RS09665	COG0285	dihydrofolate synthase activity
vsple_RS09670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
vsple_RS09675	COG0101	tRNA pseudouridine synthase activity
vsple_RS09685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
vsple_RS09690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
vsple_RS09695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
vsple_RS09705	COG0431	NADPH-dependent FMN reductase
vsple_RS09715	COG3101	peptidyl-lysine hydroxylation
vsple_RS09720	COG2860	membrane
vsple_RS09725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
vsple_RS09740	COG0515	serine threonine protein kinase
vsple_RS09740	COG2815	serine threonine protein kinase
vsple_RS09780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
vsple_RS09785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
vsple_RS09795	COG2951	lytic endotransglycosylase activity
vsple_RS09800	COG3100	YcgL domain-containing protein
vsple_RS09805	COG0850	regulation of cytokinetic process
vsple_RS09810	COG2894	cell division
vsple_RS09815	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
vsple_RS09820	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
vsple_RS09825	COG0318	PFAM AMP-dependent synthetase and ligase
vsple_RS09830	COG0596	Alpha beta hydrolase
vsple_RS09835	COG3065	identical protein binding
vsple_RS09845	COG1214	PFAM Peptidase M22, glycoprotease
vsple_RS09850	COG1199	ATP-dependent helicase activity
vsple_RS09855	COG0788	formyltetrahydrofolate deformylase activity
vsple_RS09860	COG3102	Protein conserved in bacteria
vsple_RS09880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
vsple_RS09885	COG1918	ferrous iron import across plasma membrane
vsple_RS09895	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
vsple_RS09900	COG1121	(ABC) transporter
vsple_RS09905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
vsple_RS09915	COG0045	succinate-CoA ligase (ADP-forming) activity
vsple_RS09920	COG0508	dehydrogenase complex catalyzes the overall conversion of
vsple_RS09925	COG0567	Dehydrogenase, E1 component
vsple_RS09930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
vsple_RS09935	COG1053	succinate dehydrogenase
vsple_RS09940	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
vsple_RS09955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
vsple_RS09965	COG0033	Phosphoglucomutase
vsple_RS09970	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
vsple_RS09975	COG0596	Alpha beta hydrolase
vsple_RS10000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
vsple_RS10005	COG1263	PTS System
vsple_RS10005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vsple_RS10005	COG2190	(PTS) system
vsple_RS10010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
vsple_RS10015	COG1846	Transcriptional regulator
vsple_RS10015	COG1940	carbohydrate kinase activity
vsple_RS10020	COG4651	solute:proton antiporter activity
vsple_RS10020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
vsple_RS10025	COG0367	asparagine synthase
vsple_RS10030	COG0250	Participates in transcription elongation, termination and antitermination
vsple_RS10035	COG3104	oligopeptide transport
vsple_RS10040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
vsple_RS10045	COG0563	adenylate kinase activity
vsple_RS10050	COG0326	Molecular chaperone. Has ATPase activity
vsple_RS10055	COG3710	Transcriptional regulator
vsple_RS10070	COG0622	Phosphoesterase
vsple_RS10095	COG1090	epimerase
vsple_RS10100	COG0300	oxidoreductase activity
vsple_RS10105	COG3118	belongs to the thioredoxin family
vsple_RS10110	COG0330	HflC and HflK could
vsple_RS10120	COG0789	Transcriptional regulator
vsple_RS10140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
vsple_RS10145	COG3115	cell septum assembly
vsple_RS10150	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
vsple_RS10160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
vsple_RS10165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
vsple_RS10170	COG2190	(PTS) system
vsple_RS10175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vsple_RS10180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vsple_RS10185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vsple_RS10190	COG2837	iron assimilation
vsple_RS10215	COG1393	Belongs to the ArsC family
vsple_RS10220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
vsple_RS10225	COG1876	peptidase activity
vsple_RS10240	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
vsple_RS10245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
vsple_RS10250	COG2716	regulation of RNA biosynthetic process
vsple_RS10280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
vsple_RS10315	COG3621	Patatin-like phospholipase
vsple_RS10320	COG1196	nuclear chromosome segregation
vsple_RS10370	COG4783	chaperone-mediated protein folding
vsple_RS10375	COG1393	Belongs to the ArsC family
vsple_RS10395	COG2233	PERMEase
vsple_RS10405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
vsple_RS10410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
vsple_RS10415	COG0121	glutamine amidotransferase
vsple_RS10420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
vsple_RS10425	COG1960	acyl-CoA dehydrogenase activity
vsple_RS10445	COG2226	methyltransferase
vsple_RS10450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
vsple_RS10455	COG1388	LysM domain
vsple_RS10455	COG0741	lytic transglycosylase activity
vsple_RS10470	COG0347	Belongs to the P(II) protein family
vsple_RS10480	COG0037	tRNA processing
vsple_RS10485	COG0825	malonyl-CoA metabolic process
vsple_RS10490	COG0587	DNA-directed DNA polymerase activity
vsple_RS10495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
vsple_RS10505	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vsple_RS10510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
vsple_RS10520	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
vsple_RS10530	COG0750	zinc metalloprotease
vsple_RS10540	COG0575	Belongs to the CDS family
vsple_RS10545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
vsple_RS10550	COG0233	cytoplasmic translational termination
vsple_RS10555	COG0528	UMP kinase activity
vsple_RS10570	COG0024	Methionine aminopeptidase
vsple_RS10575	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
vsple_RS10585	COG0564	pseudouridine synthase activity
vsple_RS10590	COG3098	single-species biofilm formation
vsple_RS10615	COG1671	Belongs to the UPF0178 family
vsple_RS10625	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
vsple_RS10635	COG0254	rRNA binding
vsple_RS10640	COG1720	tRNA m6t6A37 methyltransferase activity
vsple_RS10645	COG0442	prolyl-tRNA aminoacylation
vsple_RS10680	COG0366	Alpha amylase catalytic
vsple_RS10685	COG1263	PTS System
vsple_RS10685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vsple_RS10700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
vsple_RS10710	COG2011	ABC-type metal ion transport system permease component
vsple_RS10715	COG1464	Belongs to the NlpA lipoprotein family
vsple_RS10720	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
vsple_RS10730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
vsple_RS10730	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
vsple_RS10745	COG1611	Belongs to the LOG family
vsple_RS10750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vsple_RS10755	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
vsple_RS10760	COG2363	Small membrane protein
vsple_RS10770	COG0583	DNA-binding transcription factor activity
vsple_RS10775	COG0625	glutathione transferase activity
vsple_RS10780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
vsple_RS10780	COG0301	tRNA thio-modification
vsple_RS10790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
vsple_RS10795	COG1722	exodeoxyribonuclease VII activity
vsple_RS10800	COG0142	geranyltranstransferase activity
vsple_RS10805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
vsple_RS10815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
vsple_RS10820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
vsple_RS10825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
vsple_RS10845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
vsple_RS10845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
vsple_RS10850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
vsple_RS10855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
vsple_RS10870	COG1073	alpha beta
vsple_RS10875	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
vsple_RS10880	COG2252	PERMEase
vsple_RS10885	COG2195	Cleaves the N-terminal amino acid of tripeptides
vsple_RS10905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
vsple_RS10925	COG2017	converts alpha-aldose to the beta-anomer
vsple_RS10935	COG1085	galactose-1-phosphate uridylyltransferase
vsple_RS10940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
vsple_RS10945	COG0583	DNA-binding transcription factor activity
vsple_RS10950	COG2059	Chromate
vsple_RS11005	COG4964	Belongs to the GSP D family
vsple_RS11025	COG1022	Amp-dependent synthetase and ligase
vsple_RS11035	COG0583	DNA-binding transcription factor activity
vsple_RS11040	COG4628	conserved protein (DUF2132)
vsple_RS11045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
vsple_RS11050	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
vsple_RS11060	COG0560	Phosphoserine phosphatase
vsple_RS11070	COG0813	purine-nucleoside phosphorylase activity
vsple_RS11080	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
vsple_RS11085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
vsple_RS11090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
vsple_RS11095	COG0084	hydrolase, TatD family'
vsple_RS11105	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
vsple_RS11115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
vsple_RS11120	COG0456	acetyltransferase
vsple_RS11130	COG3153	acetyltransferase
vsple_RS11135	COG3154	lipid carrier protein
vsple_RS11145	COG0826	peptidase U32
vsple_RS11150	COG0826	peptidase U32
vsple_RS11155	COG0534	Mate efflux family protein
vsple_RS11175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
vsple_RS11180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
vsple_RS11185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
vsple_RS11195	COG0195	Participates in both transcription termination and antitermination
vsple_RS11200	COG0779	Required for maturation of 30S ribosomal subunits
vsple_RS11215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
vsple_RS11225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
vsple_RS11230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
vsple_RS11235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
vsple_RS11240	COG1534	Rna-binding protein
vsple_RS11245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
vsple_RS11255	COG2027	D-alanyl-D-alanine carboxypeptidase
vsple_RS11260	COG2239	Acts as a magnesium transporter
vsple_RS11265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
vsple_RS11270	COG0739	heme binding
vsple_RS11285	COG0316	Belongs to the HesB IscA family
vsple_RS11290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
vsple_RS11295	COG0628	permease
vsple_RS11310	COG0747	negative chemotaxis
vsple_RS11320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vsple_RS11325	COG0444	Belongs to the ABC transporter superfamily
vsple_RS11330	COG4608	Belongs to the ABC transporter superfamily
vsple_RS11340	COG2971	BadF BadG BcrA BcrD
vsple_RS11355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
vsple_RS11360	COG3842	ATPase activity
vsple_RS11370	COG1840	ABC-type Fe3 transport system, periplasmic component
vsple_RS11375	COG0004	ammonium transporteR
vsple_RS11390	COG1049	propionate catabolic process, 2-methylcitrate cycle
vsple_RS11395	COG1752	Esterase of the alpha-beta hydrolase superfamily
vsple_RS11400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
vsple_RS11405	COG1643	Atp-dependent helicase
vsple_RS11410	COG1489	DNA binding
vsple_RS11415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
vsple_RS11430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
vsple_RS11435	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
vsple_RS11440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
vsple_RS11445	COG0842	Transport permease protein
vsple_RS11450	COG1131	(ABC) transporter
vsple_RS11455	COG0659	secondary active sulfate transmembrane transporter activity
vsple_RS11460	COG0288	reversible hydration of carbon dioxide
vsple_RS11475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
vsple_RS11480	COG0508	dehydrogenase complex catalyzes the overall conversion of
vsple_RS11485	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
vsple_RS11500	COG0157	Belongs to the NadC ModD family
vsple_RS11505	COG4969	Belongs to the N-Me-Phe pilin family
vsple_RS11510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
vsple_RS11515	COG1459	type II secretion system
vsple_RS11525	COG0237	dephospho-CoA kinase activity
vsple_RS11530	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
vsple_RS11545	COG0336	Belongs to the RNA methyltransferase TrmD family
vsple_RS11550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
vsple_RS11560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
vsple_RS11565	COG4137	Cytochrome C assembly protein
vsple_RS11570	COG4536	flavin adenine dinucleotide binding
vsple_RS11575	COG1854	S-ribosylhomocysteine lyase activity
vsple_RS11590	COG0612	Peptidase, M16
vsple_RS11595	COG1238	metal cluster binding
vsple_RS11605	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
vsple_RS11610	COG0511	ligase activity, forming carbon-carbon bonds
vsple_RS11610	COG5016	pyruvate
vsple_RS11615	COG3630	sodium ion export across plasma membrane
vsple_RS11675	COG0527	aspartate kinase activity
vsple_RS11685	COG3152	Membrane
vsple_RS11690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
vsple_RS11695	COG1546	Belongs to the CinA family
vsple_RS11700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
vsple_RS11715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
vsple_RS11720	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
vsple_RS11725	COG0585	pseudouridine synthase activity
vsple_RS11735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
vsple_RS11740	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
vsple_RS11745	COG0148	phosphopyruvate hydratase activity
vsple_RS11755	COG3956	TIGRFAM MazG family protein
vsple_RS11760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
vsple_RS11765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
vsple_RS11770	COG2205	protein histidine kinase activity
vsple_RS11770	COG3437	response regulator, receiver
vsple_RS11770	COG3850	Histidine kinase
vsple_RS11770	COG4999	Histidine kinase
vsple_RS11775	COG0736	holo-[acyl-carrier-protein] synthase activity
vsple_RS11780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
vsple_RS11785	COG1381	Involved in DNA repair and RecF pathway recombination
vsple_RS11790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
vsple_RS11795	COG0571	ribonuclease III activity
vsple_RS11805	COG0481	GTPase activity
vsple_RS11825	COG1595	DNA-templated transcription, initiation
vsple_RS11830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
vsple_RS11835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
vsple_RS11840	COG0354	folic acid binding
vsple_RS11845	COG0442	prolyl-tRNA aminoacylation
vsple_RS11855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
vsple_RS11860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
vsple_RS11865	COG3079	Belongs to the UPF0149 family
vsple_RS11870	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
vsple_RS11880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
vsple_RS11885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
vsple_RS11890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
vsple_RS11920	COG0668	transmembrane transport
vsple_RS11925	COG0191	fructose-bisphosphate aldolase activity
vsple_RS11935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
vsple_RS11945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
vsple_RS11955	COG3091	SprT-like family
vsple_RS11960	COG2356	endonuclease I
vsple_RS11965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
vsple_RS11970	COG0189	ligase activity
vsple_RS11975	COG1678	Uncharacterized ACR, COG1678
vsple_RS12000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
vsple_RS12005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
vsple_RS12010	COG0762	integral membrane protein
vsple_RS12025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
vsple_RS12030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
vsple_RS12035	COG2066	Belongs to the glutaminase family
vsple_RS12050	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
vsple_RS12055	COG0741	lytic transglycosylase activity
vsple_RS12095	COG0840	transmembrane signaling receptor activity
vsple_RS12165	COG3437	response regulator, receiver
vsple_RS12175	COG3706	GGDEF domain
vsple_RS12180	COG0745	RESPONSE REGULATOR receiver
vsple_RS12205	COG0795	lipopolysaccharide-transporting ATPase activity
vsple_RS12210	COG0795	lipopolysaccharide-transporting ATPase activity
vsple_RS12215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
vsple_RS12220	COG2927	DNA polymerase III (CHI subunit)
vsple_RS12225	COG0525	valine-tRNA ligase activity
vsple_RS12265	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
vsple_RS12270	COG0251	oxidation-reduction process
vsple_RS12280	COG0204	Acyl-transferase
vsple_RS12285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
vsple_RS12290	COG5007	Belongs to the BolA IbaG family
vsple_RS12300	COG2854	intermembrane phospholipid transfer
vsple_RS12305	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
vsple_RS12310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
vsple_RS12315	COG1127	ABC transporter
vsple_RS12325	COG0517	IMP dehydrogenase activity
vsple_RS12325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
vsple_RS12330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
vsple_RS12340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
vsple_RS12345	COG1137	ATPase activity
vsple_RS12355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
vsple_RS12360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
vsple_RS12365	COG1660	Displays ATPase and GTPase activities
vsple_RS12370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
vsple_RS12375	COG2239	Acts as a magnesium transporter
vsple_RS12380	COG0312	modulator of DNA gyrase
vsple_RS12385	COG3028	Belongs to the UPF0307 family
vsple_RS12390	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
vsple_RS12395	COG1178	ABC-type Fe3 transport system permease component
vsple_RS12400	COG4143	(ABC) transporter
vsple_RS12405	COG0163	prenyltransferase activity
vsple_RS12410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
vsple_RS12415	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
vsple_RS12425	COG2105	PFAM AIG2 family protein
vsple_RS12430	COG2911	Protein conserved in bacteria
vsple_RS12435	COG0729	surface antigen
vsple_RS12440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vsple_RS12455	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
vsple_RS12490	COG0529	Catalyzes the synthesis of activated sulfate
vsple_RS12495	COG3273	potassium ion transport
vsple_RS12495	COG0471	metal ion transport
vsple_RS12500	COG2895	sulfate adenylyltransferase (ATP) activity
vsple_RS12505	COG0175	sulfate reduction
vsple_RS12510	COG0737	Belongs to the 5'-nucleotidase family
vsple_RS12530	COG2153	protein acetylation
vsple_RS12540	COG3061	Opacity-associated protein A
vsple_RS12540	COG3266	domain, Protein
vsple_RS12545	COG0545	Peptidyl-prolyl cis-trans isomerase
vsple_RS12555	COG0203	ribosomal protein L17
vsple_RS12560	COG0202	RNA polymerase activity
vsple_RS12565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
vsple_RS12570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
vsple_RS12575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
vsple_RS12580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
vsple_RS12585	COG0201	protein transport
vsple_RS12590	COG0200	Binds to the 23S rRNA
vsple_RS12595	COG1841	ribosomal large subunit assembly
vsple_RS12600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
vsple_RS12605	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
vsple_RS12610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
vsple_RS12615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
vsple_RS12620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
vsple_RS12630	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
vsple_RS12640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
vsple_RS12650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
vsple_RS12665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
vsple_RS12670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
vsple_RS12675	COG0089	rRNA binding
vsple_RS12680	COG0088	Forms part of the polypeptide exit tunnel
vsple_RS12685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
vsple_RS12690	COG0051	transcription antitermination factor activity, RNA binding
vsple_RS12700	COG2906	2 iron, 2 sulfur cluster binding
vsple_RS12705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
vsple_RS12710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
vsple_RS12730	COG2923	Belongs to the DsrF TusC family
vsple_RS12735	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
vsple_RS12740	COG2964	Protein conserved in bacteria
vsple_RS12745	COG0545	Peptidyl-prolyl cis-trans isomerase
vsple_RS12755	COG2900	Belongs to the SlyX family
vsple_RS12760	COG1446	asparaginase
vsple_RS12765	COG1047	Peptidyl-prolyl cis-trans
vsple_RS12770	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
vsple_RS12780	COG2249	NAD(P)H dehydrogenase (quinone) activity
vsple_RS12785	COG0488	(ABC) transporter
vsple_RS12795	COG0429	hydrolase of the alpha beta-hydrolase fold
vsple_RS12800	COG3089	Belongs to the UPF0270 family
vsple_RS12805	COG3954	Phosphoribulokinase
vsple_RS12810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
vsple_RS12820	COG1012	belongs to the aldehyde dehydrogenase family
vsple_RS12830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
vsple_RS12835	COG0512	Glutamine amidotransferase of anthranilate synthase
vsple_RS12845	COG0180	Tryptophanyl-tRNA synthetase
vsple_RS12850	COG0546	phosphoglycolate phosphatase activity
vsple_RS12855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
vsple_RS12860	COG0338	D12 class N6 adenine-specific DNA methyltransferase
vsple_RS12870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
vsple_RS12905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
vsple_RS12915	COG0678	peroxiredoxin activity
vsple_RS12915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
vsple_RS12920	COG0251	oxidation-reduction process
vsple_RS12935	COG0165	Argininosuccinate lyase
vsple_RS12935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
vsple_RS12950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
vsple_RS12955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
vsple_RS12960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
vsple_RS12970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
vsple_RS12975	COG0460	homoserine dehydrogenase
vsple_RS12975	COG0527	aspartate kinase activity
vsple_RS12980	COG0626	cystathionine gamma-synthase activity
vsple_RS12985	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
vsple_RS12990	COG0281	malic enzyme
vsple_RS12995	COG0254	rRNA binding
vsple_RS13000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
vsple_RS13005	COG1609	Transcriptional regulator
vsple_RS13015	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
vsple_RS13020	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
vsple_RS13025	COG1575	Belongs to the MenA family. Type 1 subfamily
vsple_RS13030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
vsple_RS13035	COG3074	FtsZ-dependent cytokinesis
vsple_RS13040	COG1494	fructose-1,6-bisphosphatase
vsple_RS13065	COG0149	triose-phosphate isomerase activity
vsple_RS13075	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
vsple_RS13085	COG0745	RESPONSE REGULATOR receiver
vsple_RS13090	COG2205	protein histidine kinase activity
vsple_RS13095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
vsple_RS13100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
vsple_RS13105	COG3030	protein affecting phage T7 exclusion by the F plasmid
vsple_RS13110	COG1027	Aspartate ammonia-lyase
vsple_RS13115	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
vsple_RS13120	COG4232	protein-disulfide reductase activity
vsple_RS13130	COG2095	MarC family integral membrane protein
vsple_RS13140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
vsple_RS13155	COG2205	protein histidine kinase activity
vsple_RS13155	COG2198	Histidine kinase
vsple_RS13155	COG0784	Response regulator, receiver
vsple_RS13160	COG2814	Major facilitator Superfamily
vsple_RS13175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
vsple_RS13180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
vsple_RS13185	COG0511	ligase activity, forming carbon-carbon bonds
vsple_RS13190	COG0439	Biotin carboxylase
vsple_RS13195	COG2264	protein methyltransferase activity
vsple_RS13200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
vsple_RS13205	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
vsple_RS13215	COG0138	bifunctional purine biosynthesis protein purh
vsple_RS13220	COG0151	Belongs to the GarS family
vsple_RS13235	COG1253	flavin adenine dinucleotide binding
vsple_RS13240	COG3068	Protein conserved in bacteria
vsple_RS13245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
vsple_RS13260	COG2816	NAD+ diphosphatase activity
vsple_RS13265	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
vsple_RS13275	COG0085	RNA polymerase activity
vsple_RS13285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
vsple_RS13290	COG0081	regulation of translation
vsple_RS13300	COG0250	Participates in transcription elongation, termination and antitermination
vsple_RS13305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
vsple_RS13310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
vsple_RS13335	COG1072	(Pantothenic acid kinase))
vsple_RS13345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
vsple_RS13355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
vsple_RS13460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
vsple_RS13465	COG0137	argininosuccinate synthase activity
vsple_RS13470	COG4206	TonB-dependent receptor
vsple_RS13475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
vsple_RS13490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
vsple_RS13495	COG0534	Mate efflux family protein
vsple_RS13505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
vsple_RS13510	COG2937	Belongs to the GPAT DAPAT family
vsple_RS13515	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
vsple_RS13520	COG3161	chorismate lyase activity
vsple_RS13525	COG1580	Controls the rotational direction of flagella during chemotaxis
vsple_RS13535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
vsple_RS13545	COG2177	Part of the ABC transporter FtsEX involved in
vsple_RS13550	COG2884	Cell division ATP-binding protein ftsE
vsple_RS13555	COG0552	protein localization to endoplasmic reticulum
vsple_RS13560	COG0742	ribosomal rna small subunit methyltransferase
vsple_RS13570	COG2095	MarC family integral membrane protein
vsple_RS13610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
vsple_RS13615	COG0640	Transcriptional regulator
vsple_RS13620	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
vsple_RS13625	COG1280	lysine exporter protein (LysE YggA)
vsple_RS13630	COG2267	carboxylic ester hydrolase activity
vsple_RS13635	COG0561	phosphatase activity
vsple_RS13650	COG3148	PFAM DTW domain containing protein
vsple_RS13655	COG3287	FIST C domain
vsple_RS13655	COG2200	EAL domain
vsple_RS13655	COG2199	diguanylate cyclase activity
vsple_RS13660	COG2199	diguanylate cyclase activity
vsple_RS13660	COG2200	EAL domain
vsple_RS13660	COG3287	FIST C domain
vsple_RS13665	COG1011	Hydrolase
vsple_RS13670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
vsple_RS13680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
vsple_RS13685	COG0019	diaminopimelate decarboxylase activity
vsple_RS13695	COG1965	Belongs to the frataxin family
vsple_RS13705	COG0181	hydroxymethylbilane synthase activity
vsple_RS13710	COG1587	Uroporphyrinogen-III synthase
vsple_RS13715	COG2959	enzyme of heme biosynthesis
vsple_RS13720	COG3071	HemY protein
vsple_RS13785	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
vsple_RS13800	COG3118	belongs to the thioredoxin family
vsple_RS13805	COG0513	Belongs to the DEAD box helicase family
vsple_RS13810	COG0248	Ppx GppA phosphatase
vsple_RS13815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
vsple_RS13825	COG0514	ATP-dependent DNA helicase (RecQ)
vsple_RS13830	COG2962	Rard protein
vsple_RS13840	COG1280	lysine exporter protein (LysE YggA)
vsple_RS13845	COG0405	Gamma-glutamyltransferase
vsple_RS13850	COG0210	DNA helicase
vsple_RS13860	COG3220	belongs to the UPF0276 family
vsple_RS13890	COG0006	proline dipeptidase activity
vsple_RS13890	COG0006	proline dipeptidase activity
vsple_RS13910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
vsple_RS13925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
vsple_RS13930	COG2132	Multicopper oxidase
vsple_RS13980	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
vsple_RS13990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
vsple_RS13995	COG0408	coproporphyrinogen oxidase activity
vsple_RS14000	COG0009	L-threonylcarbamoyladenylate synthase
vsple_RS14005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
vsple_RS14010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
vsple_RS14015	COG0551	DNA topoisomerase type I activity
vsple_RS14020	COG2922	Belongs to the Smg family
vsple_RS14025	COG0758	DNA mediated transformation
vsple_RS14045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
vsple_RS14045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
vsple_RS14050	COG0569	domain protein
vsple_RS14055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
vsple_RS14065	COG1272	protein, Hemolysin III
vsple_RS14070	COG4326	sporulation control protein
vsple_RS14080	COG3084	Protein conserved in bacteria
vsple_RS14090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
vsple_RS14095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
vsple_RS14140	COG3978	acetolactate synthase activity
vsple_RS14145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
vsple_RS14160	COG0583	DNA-binding transcription factor activity
vsple_RS14165	COG2814	Major facilitator Superfamily
vsple_RS14180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
vsple_RS14185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
vsple_RS14190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
vsple_RS14195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
vsple_RS14200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
vsple_RS14205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
vsple_RS14220	COG3312	ion transport
vsple_RS14225	COG1475	DNA binding
vsple_RS14230	COG1192	Involved in chromosome partitioning
vsple_RS14235	COG0357	Ribosomal RNA small subunit methyltransferase G
vsple_RS14240	COG0445	tRNA wobble uridine modification
vsple_RS14245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
vsple_RS14255	COG0706	membrane insertase activity
vsple_RS14260	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
vsple_RS14270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
vsple_RS14275	COG1126	abc transporter atp-binding protein
vsple_RS14290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
vsple_RS14305	COG1686	Belongs to the peptidase S11 family
vsple_RS14310	COG0564	pseudouridine synthase activity
vsple_RS14320	COG2130	NADP-dependent
vsple_RS14325	COG1309	transcriptional regulator
vsple_RS14330	COG0545	Peptidyl-prolyl cis-trans isomerase
vsple_RS14350	COG3604	Transcriptional regulator
vsple_RS14355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
vsple_RS14355	COG1017	nitric oxide dioxygenase activity
vsple_RS14365	COG0038	chloride channel
vsple_RS14370	COG0523	cobalamin synthesis protein
vsple_RS14375	COG0513	Belongs to the DEAD box helicase family
vsple_RS14380	COG1280	lysine exporter protein (LysE YggA)
vsple_RS14405	COG0745	RESPONSE REGULATOR receiver
vsple_RS14450	COG0183	Belongs to the thiolase family
vsple_RS14480	COG0243	molybdopterin cofactor binding
vsple_RS14495	COG3850	Histidine kinase
vsple_RS14500	COG2197	response regulator
vsple_RS14505	COG3069	C4-dicarboxylate transmembrane transporter activity
vsple_RS14515	COG0745	RESPONSE REGULATOR receiver
vsple_RS14520	COG2267	carboxylic ester hydrolase activity
vsple_RS14525	COG2067	long-chain fatty acid transport protein
vsple_RS14530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vsple_RS14535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vsple_RS14540	COG0840	transmembrane signaling receptor activity
vsple_RS14545	COG2188	Transcriptional regulator
vsple_RS14550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
vsple_RS14550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
vsple_RS14550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
vsple_RS14555	COG0383	alpha-mannosidase activity
vsple_RS14560	COG1929	Belongs to the glycerate kinase type-1 family
vsple_RS14580	COG0456	acetyltransferase
vsple_RS14580	COG1214	PFAM Peptidase M22, glycoprotease
vsple_RS14595	COG2199	diguanylate cyclase activity
vsple_RS14610	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
vsple_RS14615	COG0494	nUDIX hydrolase
vsple_RS14625	COG2425	protein containing a von Willebrand factor type A (vWA) domain
vsple_RS14670	COG0583	DNA-binding transcription factor activity
vsple_RS14675	COG0277	FAD linked oxidase domain protein
vsple_RS14685	COG0848	biopolymer transport protein
vsple_RS14720	COG3712	iron ion homeostasis
vsple_RS14760	COG0509	glycine decarboxylation via glycine cleavage system
vsple_RS14765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
vsple_RS14800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
vsple_RS14810	COG2759	Belongs to the formate--tetrahydrofolate ligase family
vsple_RS14815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
vsple_RS14830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
vsple_RS14835	COG0840	transmembrane signaling receptor activity
vsple_RS14840	COG0814	amino acid
vsple_RS14850	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
vsple_RS14855	COG0513	Belongs to the DEAD box helicase family
vsple_RS14865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vsple_RS14880	COG2200	EAL domain
vsple_RS14895	COG3038	cytochrome b561
vsple_RS14905	COG2116	formate transmembrane transporter activity
vsple_RS14910	COG0583	DNA-binding transcription factor activity
vsple_RS14920	COG3593	DNA synthesis involved in DNA repair
vsple_RS14925	COG0737	Belongs to the 5'-nucleotidase family
vsple_RS14930	COG0861	Integral membrane protein TerC family
vsple_RS14940	COG0513	Belongs to the DEAD box helicase family
vsple_RS14945	COG0729	surface antigen
vsple_RS14950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
vsple_RS14955	COG2272	Belongs to the type-B carboxylesterase lipase family
vsple_RS14970	COG1566	PFAM secretion protein HlyD family protein
vsple_RS14980	COG2985	domain, Protein
vsple_RS14990	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
vsple_RS15005	COG0583	DNA-binding transcription factor activity
vsple_RS15020	COG2267	carboxylic ester hydrolase activity
vsple_RS15025	COG2067	long-chain fatty acid transport protein
vsple_RS15040	COG2050	protein possibly involved in aromatic compounds catabolism
vsple_RS15050	COG4533	DNA binding
vsple_RS15085	COG1716	ATPase activity
vsple_RS15085	COG5001	Diguanylate cyclase
vsple_RS15090	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
vsple_RS15100	COG4181	ATPase activity
vsple_RS15105	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
vsple_RS15110	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
vsple_RS15110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
vsple_RS15115	COG1984	allophanate hydrolase subunit 2
vsple_RS15120	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
vsple_RS15130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
vsple_RS15135	COG4771	TonB-dependent receptor
vsple_RS15135	COG1629	transport
vsple_RS15140	COG0583	DNA-binding transcription factor activity
vsple_RS15145	COG1042	CoA-binding domain protein
vsple_RS15145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
vsple_RS15145	COG0045	succinate-CoA ligase (ADP-forming) activity
vsple_RS15155	COG1181	Belongs to the D-alanine--D-alanine ligase family
vsple_RS15170	COG0023	Translation Initiation Factor
vsple_RS15175	COG2801	Transposase and inactivated derivatives
vsple_RS15185	COG3140	Belongs to the UPF0181 family
vsple_RS15210	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
vsple_RS15215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
vsple_RS15230	COG3706	GGDEF domain
vsple_RS15240	COG4251	negative regulation of phosphorylation
vsple_RS15240	COG5001	Diguanylate cyclase
vsple_RS15240	COG2203	Gaf domain
vsple_RS15240	COG3706	GGDEF domain
vsple_RS15250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
vsple_RS15255	COG4149	molybdate abc transporter
vsple_RS15260	COG0725	ABC transporter, periplasmic molybdate-binding protein
vsple_RS15280	COG0189	ligase activity
vsple_RS15280	COG4067	protein conserved in archaea
vsple_RS15290	COG0602	queuosine metabolic process
vsple_RS15295	COG1328	CTP reductase activity
vsple_RS15310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
vsple_RS15315	COG3118	belongs to the thioredoxin family
vsple_RS15335	COG0534	Mate efflux family protein
vsple_RS15355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
vsple_RS15360	COG1121	(ABC) transporter
vsple_RS15365	COG0803	Belongs to the bacterial solute-binding protein 9 family
vsple_RS15405	COG0848	biopolymer transport protein
vsple_RS15410	COG0811	peptide transport
vsple_RS15415	COG0811	peptide transport
vsple_RS15430	COG1301	dicarboxylic acid transport
vsple_RS15435	COG2205	protein histidine kinase activity
vsple_RS15440	COG0745	RESPONSE REGULATOR receiver
vsple_RS15455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
vsple_RS15455	COG1648	precorrin-2 dehydrogenase activity
vsple_RS15460	COG2116	formate transmembrane transporter activity
vsple_RS15470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
vsple_RS15480	COG1280	lysine exporter protein (LysE YggA)
vsple_RS15490	COG1288	antiporter activity
vsple_RS15500	COG1028	Short-chain dehydrogenase reductase Sdr
vsple_RS15590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
vsple_RS15595	COG1366	Belongs to the anti-sigma-factor antagonist family
vsple_RS15600	COG0745	RESPONSE REGULATOR receiver
vsple_RS15620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vsple_RS15640	COG5002	protein histidine kinase activity
vsple_RS15640	COG2205	protein histidine kinase activity
vsple_RS15640	COG0784	Response regulator, receiver
vsple_RS15685	COG0714	Associated with various cellular activities
vsple_RS15690	COG0457	Tetratricopeptide repeat
vsple_RS15695	COG3119	arylsulfatase activity
vsple_RS15705	COG0784	Response regulator, receiver
vsple_RS15705	COG2205	protein histidine kinase activity
vsple_RS15710	COG0784	Response regulator, receiver
vsple_RS15710	COG2198	Histidine kinase
vsple_RS15710	COG5002	protein histidine kinase activity
vsple_RS15715	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
vsple_RS15720	COG0454	-acetyltransferase
vsple_RS15730	COG3278	Belongs to the heme-copper respiratory oxidase family
vsple_RS15755	COG2205	protein histidine kinase activity
vsple_RS15760	COG0745	RESPONSE REGULATOR receiver
vsple_RS15795	COG0642	Histidine kinase
vsple_RS15800	COG0745	RESPONSE REGULATOR receiver
vsple_RS15815	COG4608	Belongs to the ABC transporter superfamily
vsple_RS15820	COG0444	Belongs to the ABC transporter superfamily
vsple_RS15825	COG4166	transmembrane transport
vsple_RS15830	COG4239	(ABC) transporter, permease
vsple_RS15835	COG4174	ABC transporter (Permease)
vsple_RS15840	COG4172	Belongs to the ABC transporter superfamily
vsple_RS15845	COG4239	(ABC) transporter, permease
vsple_RS15850	COG4174	ABC transporter (Permease)
vsple_RS15855	COG4166	transmembrane transport
vsple_RS15865	COG1869	D-ribose catabolic process
vsple_RS15870	COG1129	ABC transporter
vsple_RS15875	COG1172	Belongs to the binding-protein-dependent transport system permease family
vsple_RS15880	COG1879	ABC-type sugar transport system periplasmic component
vsple_RS15885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
vsple_RS15890	COG1609	Transcriptional regulator
vsple_RS15895	COG2205	protein histidine kinase activity
vsple_RS15895	COG0784	Response regulator, receiver
vsple_RS15905	COG0583	DNA-binding transcription factor activity
vsple_RS15915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
vsple_RS15960	COG2801	Transposase and inactivated derivatives
vsple_RS16045	COG3547	Transposase (IS116 IS110 IS902 family)
vsple_RS16060	COG0243	molybdopterin cofactor binding
vsple_RS16065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
vsple_RS16065	COG2146	nitrite reductase [NAD(P)H] activity
vsple_RS16075	COG2223	nitrite transmembrane transporter activity
vsple_RS16080	COG2815	serine threonine protein kinase
vsple_RS16080	COG0515	serine threonine protein kinase
vsple_RS16085	COG1609	Transcriptional regulator
vsple_RS16090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
vsple_RS16090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
vsple_RS16095	COG1105	Belongs to the carbohydrate kinase PfkB family
vsple_RS16100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
vsple_RS16100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
vsple_RS16100	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
vsple_RS16110	COG0625	glutathione transferase activity
vsple_RS16145	COG1629	transport
vsple_RS16155	COG2205	protein histidine kinase activity
vsple_RS16155	COG2198	Histidine kinase
vsple_RS16155	COG0784	Response regulator, receiver
vsple_RS16160	COG1879	ABC-type sugar transport system periplasmic component
vsple_RS16165	COG1803	Methylglyoxal synthase
vsple_RS16175	COG0210	DNA helicase
vsple_RS16180	COG1289	transmembrane transporter activity
vsple_RS16200	COG0583	DNA-binding transcription factor activity
vsple_RS16255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
vsple_RS16260	COG1328	CTP reductase activity
vsple_RS16265	COG2264	protein methyltransferase activity
vsple_RS16285	COG1011	Hydrolase
vsple_RS16295	COG1454	alcohol dehydrogenase
vsple_RS16320	COG2249	NAD(P)H dehydrogenase (quinone) activity
vsple_RS16340	COG3153	acetyltransferase
vsple_RS16340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
vsple_RS16345	COG1063	alcohol dehydrogenase
vsple_RS16350	COG0156	8-amino-7-oxononanoate synthase activity
vsple_RS16355	COG2211	Major facilitator Superfamily
vsple_RS16365	COG0346	lactoylglutathione lyase activity
vsple_RS16385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
vsple_RS16400	COG0393	Putative heavy-metal-binding
vsple_RS16420	COG1132	(ABC) transporter
vsple_RS16425	COG1132	(ABC) transporter
vsple_RS16430	COG2988	succinylglutamate desuccinylase activity
vsple_RS16435	COG0523	cobalamin synthesis protein
vsple_RS16445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
vsple_RS16455	COG1621	beta-fructofuranosidase activity
vsple_RS16460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
vsple_RS16465	COG1263	PTS System
vsple_RS16465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vsple_RS16470	COG1609	Transcriptional regulator
vsple_RS16485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
vsple_RS16500	COG1760	l-serine dehydratase
vsple_RS16510	COG1609	Transcriptional regulator
vsple_RS16515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
vsple_RS16520	COG3265	gluconokinase activity
vsple_RS16525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
vsple_RS16525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
vsple_RS16535	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
vsple_RS16545	COG2188	Transcriptional regulator
vsple_RS16555	COG3842	ATPase activity
vsple_RS16560	COG1629	transport
vsple_RS16565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
vsple_RS16570	COG1840	ABC-type Fe3 transport system, periplasmic component
vsple_RS16575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
vsple_RS16580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
vsple_RS16590	COG2885	chlorophyll binding
vsple_RS16590	COG3047	cAMP biosynthetic process
vsple_RS16595	COG1765	OsmC-like protein
vsple_RS16600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vsple_RS16600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vsple_RS16605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
vsple_RS16610	COG0569	domain protein
vsple_RS16615	COG0668	transmembrane transport
vsple_RS16620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
vsple_RS16630	COG3152	Membrane
vsple_RS16640	COG1028	Short-chain dehydrogenase reductase Sdr
vsple_RS16650	COG3530	Putative quorum-sensing-regulated virulence factor
vsple_RS16660	COG0109	protoheme IX farnesyltransferase activity
vsple_RS16685	COG1845	cytochrome c oxidase, subunit III
vsple_RS16700	COG1565	acr, cog1565
vsple_RS16700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
vsple_RS16705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
vsple_RS16710	COG1280	lysine exporter protein (LysE YggA)
vsple_RS16715	COG0179	Fumarylacetoacetate (FAA) hydrolase
vsple_RS16725	COG0443	Heat shock 70 kDa protein
vsple_RS16745	COG2205	protein histidine kinase activity
vsple_RS16745	COG0784	Response regulator, receiver
vsple_RS16750	COG1879	ABC-type sugar transport system periplasmic component
vsple_RS16755	COG2827	Endonuclease containing a URI domain
vsple_RS16760	COG3132	Protein of unknown function, DUF480
vsple_RS16770	COG2926	Belongs to the UPF0265 family
vsple_RS16785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
vsple_RS16790	COG1151	hydroxylamine reductase activity
vsple_RS16815	COG0531	amino acid
vsple_RS16840	COG1566	PFAM secretion protein HlyD family protein
vsple_RS16845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
vsple_RS16850	COG0402	S-adenosylhomocysteine deaminase activity
vsple_RS16855	COG1278	Cold shock
vsple_RS16860	COG3706	GGDEF domain
vsple_RS16875	COG0513	Belongs to the DEAD box helicase family
vsple_RS16900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
vsple_RS16905	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
vsple_RS16910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
vsple_RS16915	COG2205	protein histidine kinase activity
vsple_RS16920	COG0745	RESPONSE REGULATOR receiver
vsple_RS16925	COG5001	Diguanylate cyclase
vsple_RS16930	COG2186	Transcriptional regulator
vsple_RS16935	COG1131	(ABC) transporter
vsple_RS16960	COG0564	pseudouridine synthase activity
vsple_RS16985	COG0189	ligase activity
vsple_RS16990	COG0189	ligase activity
vsple_RS16990	COG4067	protein conserved in archaea
vsple_RS17005	COG0584	glycerophosphoryl diester phosphodiesterase
vsple_RS17020	COG0673	inositol 2-dehydrogenase activity
vsple_RS17030	COG2999	glutathione oxidoreductase activity
vsple_RS17035	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
vsple_RS17045	COG0534	Mate efflux family protein
vsple_RS17105	COG1901	pseudouridine methyltransferase
vsple_RS17115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
vsple_RS17135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
vsple_RS17145	COG0583	DNA-binding transcription factor activity
vsple_RS17150	COG2910	NAD(P)H-binding
vsple_RS17170	COG4221	oxidoreductase activity
vsple_RS17180	COG2358	TRAP transporter, solute receptor (TAXI family
vsple_RS17185	COG3047	cAMP biosynthetic process
vsple_RS17190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
vsple_RS17205	COG3639	organic phosphonate transmembrane transporter activity
vsple_RS17210	COG3639	organic phosphonate transmembrane transporter activity
vsple_RS17215	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
vsple_RS17230	COG2204	response regulator
vsple_RS17260	COG0583	DNA-binding transcription factor activity
vsple_RS17280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
vsple_RS17285	COG0840	transmembrane signaling receptor activity
vsple_RS17310	COG3842	ATPase activity
vsple_RS17315	COG0546	phosphoglycolate phosphatase activity
vsple_RS17340	COG0583	DNA-binding transcription factor activity
vsple_RS17355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
vsple_RS17360	COG2200	EAL domain
vsple_RS17370	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
vsple_RS17400	COG1012	belongs to the aldehyde dehydrogenase family
vsple_RS17405	COG3284	Transcriptional regulator
vsple_RS17410	COG0583	DNA-binding transcription factor activity
vsple_RS17415	COG0625	glutathione transferase activity
vsple_RS17425	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
vsple_RS17435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vsple_RS17440	COG0601	transmembrane transport
vsple_RS17445	COG0747	negative chemotaxis
vsple_RS17450	COG4172	Belongs to the ABC transporter superfamily
vsple_RS17460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
vsple_RS17465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
vsple_RS17470	COG1984	allophanate hydrolase subunit 2
vsple_RS17475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
vsple_RS17485	COG2186	Transcriptional regulator
vsple_RS17495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
vsple_RS17505	COG0402	S-adenosylhomocysteine deaminase activity
vsple_RS17525	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
vsple_RS17530	COG4266	Belongs to the allantoicase family
vsple_RS17550	COG2252	PERMEase
vsple_RS17575	COG2084	Dehydrogenase
vsple_RS17580	COG3622	Belongs to the hyi family
vsple_RS17585	COG3960	tartronate-semialdehyde synthase activity
vsple_RS17590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
vsple_RS17600	COG1846	Transcriptional regulator
vsple_RS17630	COG1067	ATP-dependent peptidase activity
vsple_RS17640	COG4172	Belongs to the ABC transporter superfamily
vsple_RS17645	COG1505	serine-type exopeptidase activity
vsple_RS17650	COG0583	DNA-binding transcription factor activity
vsple_RS17655	COG1620	l-lactate permease
vsple_RS17660	COG1304	FMN binding
vsple_RS17670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
vsple_RS17670	COG2207	Transcriptional regulator
vsple_RS17675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
vsple_RS17685	COG1054	Belongs to the UPF0176 family
vsple_RS17705	COG5001	Diguanylate cyclase
vsple_RS17715	COG1741	Belongs to the pirin family
vsple_RS17720	COG3123	guanosine phosphorylase activity
vsple_RS17735	COG0596	Alpha beta hydrolase
vsple_RS17765	COG3788	relative of glutathione S-transferase, MAPEG superfamily
vsple_RS17770	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
vsple_RS17785	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
vsple_RS17805	COG0363	glucosamine-6-phosphate deaminase activity
vsple_RS17810	COG3722	fumarate hydratase activity
vsple_RS17815	COG0246	Mannitol dehydrogenase
vsple_RS17820	COG2213	PTS system mannitol-specific
vsple_RS17820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
vsple_RS17835	COG0786	glutamate:sodium symporter activity
vsple_RS17855	COG1595	DNA-templated transcription, initiation
vsple_RS17860	COG3806	Anti-sigma factor
vsple_RS17870	COG0415	Belongs to the DNA photolyase family
vsple_RS17880	COG0300	oxidoreductase activity
vsple_RS17895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
vsple_RS17915	COG0450	alkyl hydroperoxide reductase
vsple_RS17945	COG1902	pentaerythritol trinitrate reductase activity
vsple_RS17955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
vsple_RS17960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
vsple_RS17970	COG0612	Peptidase, M16
vsple_RS17975	COG3279	Response regulator of the LytR AlgR family
vsple_RS17980	COG3275	phosphorelay sensor kinase activity
vsple_RS18000	COG0577	efflux transmembrane transporter activity
vsple_RS18000	COG1136	(ABC) transporter
vsple_RS18020	COG2084	Dehydrogenase
vsple_RS18035	COG0217	transcriptional regulatory protein
vsple_RS18050	COG3186	Phenylalanine-4-hydroxylase
vsple_RS18055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
vsple_RS18060	COG0625	glutathione transferase activity
vsple_RS18070	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
vsple_RS18090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
vsple_RS18090	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
vsple_RS18100	COG0444	Belongs to the ABC transporter superfamily
vsple_RS18105	COG4608	Belongs to the ABC transporter superfamily
vsple_RS18130	COG1444	tRNA N-acetyltransferase activity
vsple_RS18170	COG0259	pyridoxamine-phosphate oxidase activity
vsple_RS18245	COG1132	(ABC) transporter
vsple_RS18260	COG1757	Na H antiporter
vsple_RS18265	COG0174	glutamine synthetase
vsple_RS18270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
vsple_RS18275	COG1917	Cupin 2, conserved barrel domain protein
vsple_RS18275	COG1396	sequence-specific DNA binding
vsple_RS18280	COG1012	belongs to the aldehyde dehydrogenase family
vsple_RS18285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
vsple_RS18295	COG2957	Belongs to the agmatine deiminase family
vsple_RS18300	COG1012	belongs to the aldehyde dehydrogenase family
vsple_RS18305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
vsple_RS18335	COG1176	ABC-type spermidine putrescine transport system, permease component I
vsple_RS18345	COG3842	ATPase activity
vsple_RS18365	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
vsple_RS18375	COG4145	pantothenate transmembrane transporter activity
vsple_RS18380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
vsple_RS18385	COG0800	Aldolase
vsple_RS18395	COG1309	transcriptional regulator
vsple_RS18400	COG1012	belongs to the aldehyde dehydrogenase family
vsple_RS18420	COG4175	Glycine betaine
vsple_RS18425	COG1846	Transcriptional regulator
vsple_RS18435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
vsple_RS18445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
vsple_RS18460	COG3321	synthase
vsple_RS18460	COG0604	alcohol dehydrogenase
vsple_RS18460	COG1028	Short-chain dehydrogenase reductase Sdr
vsple_RS18475	COG2723	6-phospho-beta-galactosidase activity
vsple_RS18480	COG1609	Transcriptional regulator
vsple_RS18490	COG0110	maltose O-acetyltransferase activity
vsple_RS18495	COG2814	Major facilitator Superfamily
vsple_RS18500	COG0583	DNA-binding transcription factor activity
vsple_RS18510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
vsple_RS18530	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
vsple_RS18535	COG1120	ATPase activity
vsple_RS18555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
vsple_RS18560	COG1349	DNA-binding transcription factor activity
vsple_RS18565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
vsple_RS18570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
vsple_RS18575	COG0798	PFAM Bile acid sodium symporter
vsple_RS18590	COG1309	transcriptional regulator
vsple_RS18605	COG0561	phosphatase activity
vsple_RS18630	COG0583	DNA-binding transcription factor activity
vsple_RS18640	COG0673	inositol 2-dehydrogenase activity
vsple_RS18650	COG1349	DNA-binding transcription factor activity
vsple_RS18655	COG2084	Dehydrogenase
vsple_RS18660	COG3395	kinase activity
vsple_RS18665	COG0235	Class ii aldolase
vsple_RS18670	COG3622	Belongs to the hyi family
vsple_RS18675	COG2610	gluconate transmembrane transporter activity
vsple_RS18680	COG1929	Belongs to the glycerate kinase type-1 family
vsple_RS18685	COG4667	esterase of the alpha-beta hydrolase superfamily
vsple_RS18690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
vsple_RS18705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
vsple_RS18715	COG0204	Acyl-transferase
vsple_RS18720	COG2384	SAM-dependent methyltransferase
vsple_RS18735	COG4580	involved in the transport of maltose and maltodextrins
vsple_RS18785	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
vsple_RS18790	COG1162	GTPase activity
vsple_RS18795	COG1999	signal sequence binding
vsple_RS18815	COG0058	SHG alpha-glucan phosphorylase activity
vsple_RS18820	COG1640	4-alpha-glucanotransferase
vsple_RS18825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
vsple_RS18840	COG1122	ATPase activity
vsple_RS18845	COG4720	Psort location CytoplasmicMembrane, score
vsple_RS18850	COG1566	PFAM secretion protein HlyD family protein
vsple_RS18880	COG0813	purine-nucleoside phosphorylase activity
vsple_RS18885	COG1376	ErfK ybiS ycfS ynhG family protein
vsple_RS18885	COG1388	LysM domain
vsple_RS18895	COG0513	Belongs to the DEAD box helicase family
vsple_RS18900	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
vsple_RS18905	COG5380	lipid catabolic process
vsple_RS18910	COG1770	oligopeptidase
vsple_RS18945	COG0573	inorganic phosphate transmembrane transporter activity
vsple_RS18950	COG0581	inorganic phosphate transmembrane transporter activity
vsple_RS18955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
vsple_RS18960	COG3706	GGDEF domain
vsple_RS18975	COG2304	oxidoreductase activity
vsple_RS18995	COG0714	Associated with various cellular activities
vsple_RS19015	COG3842	ATPase activity
vsple_RS19025	COG1175	transmembrane transport
vsple_RS19030	COG3833	ABC-type maltose transport systems, permease component
vsple_RS19065	COG0577	efflux transmembrane transporter activity
vsple_RS19070	COG1136	(ABC) transporter
vsple_RS19080	COG0312	modulator of DNA gyrase
vsple_RS19085	COG0312	modulator of DNA gyrase
vsple_RS19100	COG0583	DNA-binding transcription factor activity
vsple_RS19110	COG1012	belongs to the aldehyde dehydrogenase family
vsple_RS19115	COG1414	Transcriptional regulator
vsple_RS19120	COG0280	phosphate acetyltransferase
vsple_RS19125	COG0730	response to heat
vsple_RS19155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
vsple_RS19160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
vsple_RS19165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
vsple_RS19170	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
vsple_RS19170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
vsple_RS19190	COG0418	dihydroorotase activity
vsple_RS19195	COG0401	homolog of Blt101
vsple_RS19200	COG0633	Ferredoxin
vsple_RS19200	COG3217	Mosc domain protein beta barrel domain protein
vsple_RS19205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
vsple_RS19250	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
vsple_RS19255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
vsple_RS19265	COG0848	biopolymer transport protein
vsple_RS19270	COG0811	peptide transport
vsple_RS19275	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
vsple_RS19285	COG3721	Heme iron utilization protein
vsple_RS19290	COG0748	coenzyme F420 binding
vsple_RS19295	COG2096	Adenosyltransferase
vsple_RS19300	COG0784	Response regulator, receiver
vsple_RS19300	COG0835	chemotaxis
vsple_RS19305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
vsple_RS19310	COG0366	Alpha amylase catalytic
vsple_RS19320	COG3314	Sporulation integral membrane protein YlbJ
vsple_RS19345	COG0739	heme binding
vsple_RS19350	COG5001	Diguanylate cyclase
vsple_RS19355	COG0583	DNA-binding transcription factor activity
vsple_RS19360	COG2814	Major facilitator Superfamily
vsple_RS19380	COG0697	spore germination
vsple_RS19395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
vsple_RS19395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
vsple_RS19405	COG4232	protein-disulfide reductase activity
vsple_RS19420	COG0668	transmembrane transport
vsple_RS19435	COG4989	oxidoreductase activity
vsple_RS19440	COG0513	Belongs to the DEAD box helicase family
vsple_RS19455	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
vsple_RS19460	COG0513	Belongs to the DEAD box helicase family
vsple_RS19465	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
vsple_RS19470	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
vsple_RS19475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
vsple_RS19480	COG0667	Aldo Keto reductase
vsple_RS19490	COG2195	Cleaves the N-terminal amino acid of tripeptides
vsple_RS19525	COG3344	reverse transcriptase
vsple_RS19530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
vsple_RS19545	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
vsple_RS19550	COG0513	Belongs to the DEAD box helicase family
vsple_RS19555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
vsple_RS19565	COG1396	sequence-specific DNA binding
vsple_RS19570	COG3135	benzoate transporter
vsple_RS19575	COG0840	transmembrane signaling receptor activity
vsple_RS19580	COG0840	transmembrane signaling receptor activity
vsple_RS19585	COG0583	DNA-binding transcription factor activity
vsple_RS19590	COG0534	Mate efflux family protein
vsple_RS19610	COG0516	GMP reductase activity
vsple_RS19630	COG1061	Type III restriction enzyme res subunit
vsple_RS19670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
vsple_RS19675	COG0732	type I restriction modification DNA specificity domain
vsple_RS19695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
vsple_RS19785	COG0437	4 iron, 4 sulfur cluster binding
vsple_RS19790	COG0348	domain, Protein
vsple_RS19810	COG0351	phosphomethylpyrimidine kinase
vsple_RS19815	COG1116	anion transmembrane transporter activity
vsple_RS19820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
vsple_RS19825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
vsple_RS19830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
vsple_RS19855	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vsple_RS19875	COG0800	Aldolase
vsple_RS19880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
vsple_RS19885	COG1917	Cupin 2, conserved barrel domain protein
vsple_RS19905	COG4607	ABC-type enterochelin transport system periplasmic component
vsple_RS19910	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
vsple_RS19915	COG4605	iron ion homeostasis
vsple_RS19920	COG4604	ABC transporter, ATP-binding protein
vsple_RS19935	COG2186	Transcriptional regulator
vsple_RS19940	COG2186	Transcriptional regulator
vsple_RS19950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
vsple_RS19955	COG0583	DNA-binding transcription factor activity
vsple_RS19960	COG2814	Major facilitator Superfamily
vsple_RS19965	COG1560	Kdo2-lipid A biosynthetic process
vsple_RS19970	COG0840	transmembrane signaling receptor activity
vsple_RS19975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
vsple_RS19995	COG2897	thiosulfate sulfurtransferase activity
vsple_RS20025	COG0302	gtp cyclohydrolase
vsple_RS20035	COG4681	YaeQ
vsple_RS20040	COG1278	Cold shock
vsple_RS20045	COG2133	pyrroloquinoline quinone binding
vsple_RS20050	COG2814	Major facilitator Superfamily
vsple_RS20075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
vsple_RS20080	COG1024	Enoyl-CoA hydratase
vsple_RS20090	COG0471	metal ion transport
vsple_RS20090	COG3273	potassium ion transport
vsple_RS20110	COG4977	sequence-specific DNA binding
vsple_RS20115	COG4206	TonB-dependent receptor
vsple_RS20120	COG0765	amino acid transport
vsple_RS20125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vsple_RS20130	COG0765	amino acid transport
vsple_RS20135	COG1126	abc transporter atp-binding protein
vsple_RS20140	COG1979	alcohol dehydrogenase
vsple_RS20145	COG2207	Transcriptional regulator
vsple_RS20185	COG0583	DNA-binding transcription factor activity
vsple_RS20200	COG1566	PFAM secretion protein HlyD family protein
vsple_RS20225	COG2194	sulfuric ester hydrolase activity
vsple_RS20240	COG4771	TonB-dependent receptor
vsple_RS20245	COG2382	esterase
vsple_RS20295	COG2161	toxin-antitoxin pair type II binding
vsple_RS20300	COG4115	mRNA cleavage
vsple_RS20305	COG2233	PERMEase
vsple_RS20320	COG0697	spore germination
vsple_RS20325	COG1917	Cupin 2, conserved barrel domain protein
vsple_RS20325	COG2207	Transcriptional regulator
vsple_RS20335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
vsple_RS20345	COG0523	cobalamin synthesis protein
vsple_RS20350	COG0583	DNA-binding transcription factor activity
vsple_RS20355	COG0656	L-ascorbic acid biosynthetic process
vsple_RS20360	COG2249	NAD(P)H dehydrogenase (quinone) activity
vsple_RS20375	COG4771	TonB-dependent receptor
vsple_RS20395	COG2207	Transcriptional regulator
vsple_RS20395	COG1917	Cupin 2, conserved barrel domain protein
vsple_RS20440	COG4303	Ethanolamine ammonia lyase large subunit
vsple_RS20450	COG0531	amino acid
vsple_RS20455	COG0583	DNA-binding transcription factor activity
vsple_RS20460	COG0625	glutathione transferase activity
vsple_RS20465	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
vsple_RS20475	COG1609	Transcriptional regulator
vsple_RS20495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
vsple_RS20500	COG2015	COG2015, Alkyl sulfatase and related hydrolases
vsple_RS20505	COG0583	DNA-binding transcription factor activity
vsple_RS20530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vsple_RS20535	COG1309	transcriptional regulator
vsple_RS20545	COG0456	acetyltransferase
vsple_RS20565	COG2801	Transposase and inactivated derivatives
vsple_RS20570	COG2801	Transposase and inactivated derivatives
vsple_RS20590	COG0446	pyridine nucleotide-disulphide oxidoreductase
vsple_RS20590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
vsple_RS20615	COG3842	ATPase activity
vsple_RS20625	COG1175	transmembrane transport
vsple_RS20630	COG0395	ABC-type sugar transport system, permease component
vsple_RS20650	COG1120	ATPase activity
vsple_RS20655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
vsple_RS20660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
vsple_RS20665	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
vsple_RS20670	COG4772	TonB-dependent receptor
vsple_RS20685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
vsple_RS20700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
vsple_RS20735	COG0346	lactoylglutathione lyase activity
vsple_RS20775	COG3833	ABC-type maltose transport systems, permease component
vsple_RS20780	COG1175	transmembrane transport
vsple_RS20785	COG2182	Extracellular solute-binding protein
vsple_RS20795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vsple_RS20810	COG3842	ATPase activity
vsple_RS20825	COG0641	radical SAM
vsple_RS20835	COG1132	(ABC) transporter
vsple_RS20840	COG4774	siderophore transport
vsple_RS20845	COG1120	ATPase activity
vsple_RS20875	COG0583	DNA-binding transcription factor activity
vsple_RS20880	COG0783	Belongs to the Dps family
vsple_RS20885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
vsple_RS20895	COG0667	Aldo Keto reductase
vsple_RS20900	COG0583	DNA-binding transcription factor activity
vsple_RS20910	COG1027	Aspartate ammonia-lyase
vsple_RS20920	COG1070	Carbohydrate kinase
vsple_RS20925	COG0277	FAD linked oxidase domain protein
vsple_RS20930	COG1028	Short-chain dehydrogenase reductase Sdr
vsple_RS20955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vsple_RS20965	COG0450	alkyl hydroperoxide reductase
vsple_RS20970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
vsple_RS20975	COG0800	Aldolase
vsple_RS20985	COG1917	Cupin 2, conserved barrel domain protein
vsple_RS20995	COG1028	Short-chain dehydrogenase reductase Sdr
vsple_RS21015	COG0840	transmembrane signaling receptor activity
vsple_RS21040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
vsple_RS21045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
vsple_RS21050	COG1904	glucuronate isomerase
vsple_RS21060	COG1414	Transcriptional regulator
vsple_RS21070	COG1741	Belongs to the pirin family
vsple_RS21075	COG2259	Doxx family
vsple_RS21085	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
vsple_RS21090	COG3683	transport system, periplasmic component
vsple_RS21105	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
vsple_RS21110	COG2059	Chromate
vsple_RS21115	COG2059	Chromate
vsple_RS21125	COG1802	Transcriptional regulator
vsple_RS21135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
vsple_RS21135	COG0302	gtp cyclohydrolase
vsple_RS21140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
vsple_RS21155	COG2113	Glycine betaine
vsple_RS21160	COG4176	ABC-type proline glycine betaine transport system permease component
vsple_RS21165	COG4175	Glycine betaine
vsple_RS21170	COG0456	acetyltransferase
vsple_RS21175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
vsple_RS21180	COG0662	Cupin 2, conserved barrel domain protein
vsple_RS21185	COG0527	aspartate kinase activity
vsple_RS21195	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
vsple_RS21220	COG1349	DNA-binding transcription factor activity
vsple_RS21225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
vsple_RS21225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
vsple_RS21235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
vsple_RS21240	COG3395	kinase activity
vsple_RS21245	COG0235	Class ii aldolase
vsple_RS21250	COG3622	Belongs to the hyi family
vsple_RS21265	COG2267	carboxylic ester hydrolase activity
vsple_RS21270	COG2433	Pfam Transposase IS66
vsple_RS21275	COG3385	transposase activity
vsple_RS21290	COG5433	transposase activity
vsple_RS21295	COG4115	mRNA cleavage
vsple_RS21300	COG2161	toxin-antitoxin pair type II binding
vsple_RS21325	COG3048	D-serine ammonia-lyase activity
vsple_RS21345	COG4948	Mandelate Racemase Muconate Lactonizing
vsple_RS21365	COG0848	biopolymer transport protein
vsple_RS21370	COG0811	peptide transport
vsple_RS21375	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
vsple_RS21390	COG1192	Involved in chromosome partitioning
vsple_RS21415	COG0415	Belongs to the DNA photolyase family
vsple_RS21430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
vsple_RS21430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
vsple_RS21440	COG1733	regulation of RNA biosynthetic process
vsple_RS21475	COG1609	Transcriptional regulator
vsple_RS21485	COG2182	Extracellular solute-binding protein
vsple_RS21490	COG1175	transmembrane transport
vsple_RS21495	COG3833	ABC-type maltose transport systems, permease component
vsple_RS21505	COG1874	Beta-galactosidase
vsple_RS21510	COG4580	involved in the transport of maltose and maltodextrins
vsple_RS21535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
vsple_RS21540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
vsple_RS21545	COG1120	ATPase activity
vsple_RS21550	COG0583	DNA-binding transcription factor activity
vsple_RS21555	COG4774	siderophore transport
vsple_RS21580	COG0653	protein targeting
vsple_RS21595	COG0210	DNA helicase
vsple_RS21610	COG1279	arginine transmembrane transporter activity
vsple_RS21615	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
vsple_RS21625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
vsple_RS21630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
vsple_RS21635	COG1120	ATPase activity
vsple_RS21645	COG0583	DNA-binding transcription factor activity
vsple_RS21650	COG0697	spore germination
vsple_RS21655	COG2207	Transcriptional regulator
vsple_RS21660	COG0596	Alpha beta hydrolase
vsple_RS21665	COG0583	DNA-binding transcription factor activity
vsple_RS21710	COG3250	beta-galactosidase activity
vsple_RS21720	COG4580	involved in the transport of maltose and maltodextrins
vsple_RS21730	COG2211	Major facilitator Superfamily
vsple_RS21735	COG1320	monovalent cation:proton antiporter activity
vsple_RS21740	COG2212	antiporter activity
vsple_RS21745	COG1863	multisubunit Na H antiporter MnhE subunit
vsple_RS21750	COG0651	ATP synthesis coupled electron transport
vsple_RS21755	COG1006	Multisubunit Na H antiporter MnhC subunit
vsple_RS21760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
vsple_RS21760	COG2111	Na H antiporter
vsple_RS21770	COG0589	response to stress
vsple_RS21775	COG3590	peptidase
vsple_RS21790	COG3119	arylsulfatase activity
vsple_RS21805	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
vsple_RS21835	COG0745	RESPONSE REGULATOR receiver
vsple_RS21840	COG0642	Histidine kinase
vsple_RS21850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
vsple_RS21855	COG0583	DNA-binding transcription factor activity
vsple_RS21860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
vsple_RS21865	COG0435	Glutathione S-transferase
vsple_RS21870	COG0583	DNA-binding transcription factor activity
vsple_RS21875	COG2204	response regulator
vsple_RS21900	COG1597	lipid kinase activity
vsple_RS21900	COG1803	Methylglyoxal synthase
vsple_RS21905	COG0668	transmembrane transport
vsple_RS21930	COG0628	permease