locus-tag	class	description
LDP65_RS00010	COG0592	DNA-directed DNA polymerase activity
LDP65_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDP65_RS00020	COG0187	DNA topoisomerase II activity
LDP65_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
LDP65_RS00030	COG3977	Valine--pyruvate aminotransferase
LDP65_RS00045	COG0751	glycine-tRNA ligase activity
LDP65_RS00055	COG2119	membrane
LDP65_RS00080	COG0604	alcohol dehydrogenase
LDP65_RS00085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LDP65_RS00090	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LDP65_RS00095	COG3454	Phosphonate metabolism
LDP65_RS00100	COG4778	phosphonate C-P lyase system protein PhnL
LDP65_RS00105	COG4107	phosphonate C-P lyase system protein PhnK
LDP65_RS00110	COG3627	carbon phosphorus lyase activity
LDP65_RS00115	COG3626	phosphonate metabolism
LDP65_RS00120	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LDP65_RS00125	COG3624	Phosphonate C-P lyase system protein PhnG
LDP65_RS00130	COG2188	Transcriptional regulator
LDP65_RS00135	COG3639	organic phosphonate transmembrane transporter activity
LDP65_RS00140	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LDP65_RS00165	COG1739	Uncharacterized protein family UPF0029
LDP65_RS00170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDP65_RS00175	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
LDP65_RS00220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDP65_RS00225	COG0583	DNA-binding transcription factor activity
LDP65_RS00230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LDP65_RS00235	COG2960	long-chain fatty acid transporting porin activity
LDP65_RS00240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDP65_RS00245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDP65_RS00250	COG1309	transcriptional regulator
LDP65_RS00290	COG4172	Belongs to the ABC transporter superfamily
LDP65_RS00295	COG4166	transmembrane transport
LDP65_RS00300	COG0601	transmembrane transport
LDP65_RS00305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDP65_RS00335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDP65_RS00335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDP65_RS00360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDP65_RS00370	COG2197	response regulator
LDP65_RS00380	COG4989	oxidoreductase activity
LDP65_RS00400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDP65_RS00405	COG3300	MHYT domain
LDP65_RS00405	COG5001	Diguanylate cyclase
LDP65_RS00410	COG2204	response regulator
LDP65_RS00415	COG3852	Histidine kinase
LDP65_RS00425	COG0174	glutamine synthetase
LDP65_RS00430	COG1217	gtp-binding protein TYPA
LDP65_RS00520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDP65_RS00525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LDP65_RS00530	COG0339	signal peptide processing
LDP65_RS00535	COG1522	sequence-specific DNA binding
LDP65_RS00540	COG5001	Diguanylate cyclase
LDP65_RS00540	COG5002	protein histidine kinase activity
LDP65_RS00555	COG0589	response to stress
LDP65_RS00560	COG1528	Iron-storage protein
LDP65_RS00570	COG2081	HI0933 family
LDP65_RS00575	COG0667	Aldo Keto reductase
LDP65_RS00620	COG4964	Belongs to the GSP D family
LDP65_RS00685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDP65_RS00695	COG3085	chromosome segregation
LDP65_RS00705	COG1322	Protein conserved in bacteria
LDP65_RS00710	COG2226	methyltransferase
LDP65_RS00715	COG3165	ubiquinone biosynthetic process from chorismate
LDP65_RS00720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LDP65_RS00725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDP65_RS00730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDP65_RS00735	COG0805	protein transport
LDP65_RS00740	COG0084	hydrolase, TatD family'
LDP65_RS00755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDP65_RS00755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDP65_RS00785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDP65_RS00795	COG1295	ribonuclease BN
LDP65_RS00805	COG0456	acetyltransferase
LDP65_RS00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LDP65_RS00825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LDP65_RS00830	COG3031	protein transport across the cell outer membrane
LDP65_RS00840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LDP65_RS00845	COG1459	type II secretion system
LDP65_RS00850	COG2165	general secretion pathway protein
LDP65_RS00855	COG2165	general secretion pathway protein
LDP65_RS00860	COG2165	general secretion pathway protein
LDP65_RS00865	COG4795	General secretion pathway protein
LDP65_RS00870	COG3156	type II secretion system protein K
LDP65_RS00875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LDP65_RS00880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LDP65_RS00890	COG0494	nUDIX hydrolase
LDP65_RS00895	COG1218	3'(2'),5'-bisphosphate nucleotidase
LDP65_RS00925	COG2937	Belongs to the GPAT DAPAT family
LDP65_RS00930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDP65_RS00935	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LDP65_RS00940	COG0534	Mate efflux family protein
LDP65_RS00945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDP65_RS00960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDP65_RS00965	COG4206	TonB-dependent receptor
LDP65_RS00980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LDP65_RS01040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDP65_RS01050	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LDP65_RS01060	COG1072	(Pantothenic acid kinase))
LDP65_RS01085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDP65_RS01090	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDP65_RS01095	COG0250	Participates in transcription elongation, termination and antitermination
LDP65_RS01110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LDP65_RS01125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LDP65_RS01130	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LDP65_RS01135	COG2816	NAD+ diphosphatase activity
LDP65_RS01145	COG1573	uracil-dna glycosylase
LDP65_RS01150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDP65_RS01155	COG3068	Protein conserved in bacteria
LDP65_RS01160	COG1253	flavin adenine dinucleotide binding
LDP65_RS01175	COG0151	Belongs to the GarS family
LDP65_RS01180	COG0138	bifunctional purine biosynthesis protein purh
LDP65_RS01195	COG0840	transmembrane signaling receptor activity
LDP65_RS01200	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LDP65_RS01205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LDP65_RS01210	COG2264	protein methyltransferase activity
LDP65_RS01215	COG0439	Biotin carboxylase
LDP65_RS01220	COG0511	ligase activity, forming carbon-carbon bonds
LDP65_RS01225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LDP65_RS01235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDP65_RS01250	COG2814	Major facilitator Superfamily
LDP65_RS01255	COG2198	Histidine kinase
LDP65_RS01255	COG0784	Response regulator, receiver
LDP65_RS01255	COG2205	protein histidine kinase activity
LDP65_RS01270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDP65_RS01285	COG3842	ATPase activity
LDP65_RS01295	COG1840	ABC-type Fe3 transport system, periplasmic component
LDP65_RS01300	COG2204	response regulator
LDP65_RS01305	COG4191	Histidine kinase
LDP65_RS01315	COG4232	protein-disulfide reductase activity
LDP65_RS01320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LDP65_RS01325	COG1027	Aspartate ammonia-lyase
LDP65_RS01335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LDP65_RS01345	COG2205	protein histidine kinase activity
LDP65_RS01350	COG0745	RESPONSE REGULATOR receiver
LDP65_RS01370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LDP65_RS01380	COG0534	Mate efflux family protein
LDP65_RS01390	COG0459	protein refolding
LDP65_RS01400	COG1285	pathogenesis
LDP65_RS01410	COG3778	Protein conserved in bacteria
LDP65_RS01445	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
LDP65_RS01455	COG4386	tail sheath protein
LDP65_RS01475	COG4387	Mu-like prophage protein GP36
LDP65_RS01485	COG4397	Mu-like prophage major head subunit gpT
LDP65_RS01520	COG4383	Mu-like prophage protein gp29
LDP65_RS01525	COG4373	Mu-like prophage FluMu protein gp28
LDP65_RS01535	COG0640	Transcriptional regulator
LDP65_RS01630	COG2842	Transposition protein
LDP65_RS01635	COG2801	Transposase and inactivated derivatives
LDP65_RS01640	COG3423	Transcriptional regulator
LDP65_RS01655	COG1509	lysine 2,3-aminomutase activity
LDP65_RS01660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LDP65_RS01695	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LDP65_RS01700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDP65_RS01705	COG1053	succinate dehydrogenase
LDP65_RS01710	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LDP65_RS01720	COG0584	glycerophosphoryl diester phosphodiesterase
LDP65_RS01725	COG0471	metal ion transport
LDP65_RS01730	COG0688	phosphatidylethanolamine metabolic process
LDP65_RS01735	COG1162	GTPase activity
LDP65_RS01740	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LDP65_RS01785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LDP65_RS01790	COG0802	atpase or kinase
LDP65_RS01795	COG0860	N-Acetylmuramoyl-L-alanine amidase
LDP65_RS01800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LDP65_RS01805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LDP65_RS01815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDP65_RS01820	COG0330	HflC and HflK could
LDP65_RS01825	COG0330	HflC and HflK could
LDP65_RS01830	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LDP65_RS01835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LDP65_RS01840	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LDP65_RS01845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDP65_RS01845	COG1017	nitric oxide dioxygenase activity
LDP65_RS01855	COG3083	sulfuric ester hydrolase activity
LDP65_RS01860	COG0557	exoribonuclease II activity
LDP65_RS01865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDP65_RS01875	COG3954	Phosphoribulokinase
LDP65_RS01885	COG0429	hydrolase of the alpha beta-hydrolase fold
LDP65_RS01890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDP65_RS01910	COG0488	(ABC) transporter
LDP65_RS01930	COG1047	Peptidyl-prolyl cis-trans
LDP65_RS01935	COG1446	asparaginase
LDP65_RS01940	COG2900	Belongs to the SlyX family
LDP65_RS01950	COG0545	Peptidyl-prolyl cis-trans isomerase
LDP65_RS01955	COG2964	Protein conserved in bacteria
LDP65_RS01960	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LDP65_RS01965	COG2923	Belongs to the DsrF TusC family
LDP65_RS01985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDP65_RS01990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDP65_RS02005	COG0051	transcription antitermination factor activity, RNA binding
LDP65_RS02010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LDP65_RS02015	COG0088	Forms part of the polypeptide exit tunnel
LDP65_RS02025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LDP65_RS02030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LDP65_RS02035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LDP65_RS02045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LDP65_RS02055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LDP65_RS02065	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LDP65_RS02070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LDP65_RS02075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LDP65_RS02080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LDP65_RS02100	COG1841	ribosomal large subunit assembly
LDP65_RS02105	COG0200	Binds to the 23S rRNA
LDP65_RS02110	COG0201	protein transport
LDP65_RS02115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LDP65_RS02120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LDP65_RS02125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LDP65_RS02135	COG0202	RNA polymerase activity
LDP65_RS02140	COG0203	ribosomal protein L17
LDP65_RS02145	COG2873	o-acetylhomoserine
LDP65_RS02155	COG0545	Peptidyl-prolyl cis-trans isomerase
LDP65_RS02160	COG3266	domain, Protein
LDP65_RS02160	COG3061	Opacity-associated protein A
LDP65_RS02195	COG0697	spore germination
LDP65_RS02200	COG2153	protein acetylation
LDP65_RS02210	COG0737	Belongs to the 5'-nucleotidase family
LDP65_RS02215	COG1648	precorrin-2 dehydrogenase activity
LDP65_RS02215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDP65_RS02220	COG0175	sulfate reduction
LDP65_RS02225	COG2895	sulfate adenylyltransferase (ATP) activity
LDP65_RS02230	COG0471	metal ion transport
LDP65_RS02230	COG3273	potassium ion transport
LDP65_RS02235	COG0529	Catalyzes the synthesis of activated sulfate
LDP65_RS02255	COG1136	(ABC) transporter
LDP65_RS02270	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LDP65_RS02275	COG0540	Belongs to the ATCase OTCase family
LDP65_RS02280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LDP65_RS02285	COG2235	arginine
LDP65_RS02320	COG4269	membrane
LDP65_RS02325	COG0501	Belongs to the peptidase M48B family
LDP65_RS02330	COG0251	oxidation-reduction process
LDP65_RS02340	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LDP65_RS02350	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LDP65_RS02360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDP65_RS02365	COG3284	Transcriptional regulator
LDP65_RS02580	COG0729	surface antigen
LDP65_RS02585	COG2911	Protein conserved in bacteria
LDP65_RS02590	COG2105	PFAM AIG2 family protein
LDP65_RS02595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LDP65_RS02600	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LDP65_RS02605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDP65_RS02610	COG0163	prenyltransferase activity
LDP65_RS02620	COG1178	ABC-type Fe3 transport system permease component
LDP65_RS02625	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LDP65_RS02635	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LDP65_RS02640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LDP65_RS02645	COG1447	Phosphotransferase system cellobiose-specific component IIA
LDP65_RS02650	COG1486	melibiose metabolic process
LDP65_RS02660	COG1609	Transcriptional regulator
LDP65_RS02670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LDP65_RS02745	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LDP65_RS02755	COG1410	methionine synthase
LDP65_RS02755	COG0646	methionine synthase
LDP65_RS02760	COG0527	aspartate kinase activity
LDP65_RS02765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LDP65_RS02775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LDP65_RS02790	COG0629	single-stranded DNA binding
LDP65_RS02795	COG2199	diguanylate cyclase activity
LDP65_RS02795	COG2200	EAL domain
LDP65_RS02820	COG3267	Type II secretory pathway component ExeA
LDP65_RS02820	COG3409	Peptidoglycan-binding domain 1 protein
LDP65_RS02830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LDP65_RS02835	COG1459	type II secretion system
LDP65_RS02845	COG2165	general secretion pathway protein
LDP65_RS02850	COG2165	general secretion pathway protein
LDP65_RS02880	COG1077	Cell shape determining protein MreB Mrl
LDP65_RS02885	COG1792	Involved in formation and maintenance of cell shape
LDP65_RS02890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LDP65_RS02895	COG0424	maF-like protein
LDP65_RS02905	COG3164	Protein of unknown function
LDP65_RS02910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDP65_RS02915	COG0312	modulator of DNA gyrase
LDP65_RS02920	COG3028	Belongs to the UPF0307 family
LDP65_RS02925	COG0312	modulator of DNA gyrase
LDP65_RS02970	COG0758	DNA mediated transformation
LDP65_RS02985	COG0582	viral genome integration into host DNA
LDP65_RS03035	COG0795	lipopolysaccharide-transporting ATPase activity
LDP65_RS03040	COG0795	lipopolysaccharide-transporting ATPase activity
LDP65_RS03050	COG2927	DNA polymerase III (CHI subunit)
LDP65_RS03055	COG0525	valine-tRNA ligase activity
LDP65_RS03060	COG0204	Acyl-transferase
LDP65_RS03070	COG5007	Belongs to the BolA IbaG family
LDP65_RS03080	COG2854	intermembrane phospholipid transfer
LDP65_RS03085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LDP65_RS03090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LDP65_RS03095	COG1127	ABC transporter
LDP65_RS03105	COG0517	IMP dehydrogenase activity
LDP65_RS03105	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LDP65_RS03110	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LDP65_RS03125	COG1137	ATPase activity
LDP65_RS03135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDP65_RS03140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDP65_RS03145	COG1660	Displays ATPase and GTPase activities
LDP65_RS03150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDP65_RS03155	COG2239	Acts as a magnesium transporter
LDP65_RS03175	COG5002	protein histidine kinase activity
LDP65_RS03180	COG0745	RESPONSE REGULATOR receiver
LDP65_RS03190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LDP65_RS03195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDP65_RS03200	COG0564	pseudouridine synthase activity
LDP65_RS03205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDP65_RS03220	COG2358	TRAP transporter, solute receptor (TAXI family
LDP65_RS03225	COG1438	arginine binding
LDP65_RS03235	COG0142	geranyltranstransferase activity
LDP65_RS03240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LDP65_RS03250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LDP65_RS03255	COG3610	response to peptide
LDP65_RS03260	COG3610	response to peptide
LDP65_RS03275	COG2967	ApaG domain
LDP65_RS03285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LDP65_RS03295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LDP65_RS03315	COG0066	3-isopropylmalate dehydratase activity
LDP65_RS03320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LDP65_RS03325	COG0473	3-isopropylmalate dehydrogenase activity
LDP65_RS03330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDP65_RS03335	COG1309	transcriptional regulator
LDP65_RS03355	COG0671	phosphoesterase, PA-phosphatase related
LDP65_RS03365	COG0583	DNA-binding transcription factor activity
LDP65_RS03370	COG1022	Amp-dependent synthetase and ligase
LDP65_RS03385	COG0028	Belongs to the TPP enzyme family
LDP65_RS03395	COG5001	Diguanylate cyclase
LDP65_RS03395	COG5002	protein histidine kinase activity
LDP65_RS03395	COG3447	MASE1 domain protein
LDP65_RS03405	COG0469	pyruvate kinase activity
LDP65_RS03410	COG1349	DNA-binding transcription factor activity
LDP65_RS03415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDP65_RS03425	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDP65_RS03450	COG0840	transmembrane signaling receptor activity
LDP65_RS03475	COG0358	DNA primase activity
LDP65_RS03480	COG1610	YqeY-like protein
LDP65_RS03485	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LDP65_RS03490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LDP65_RS03495	COG0596	Alpha beta hydrolase
LDP65_RS03500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LDP65_RS03505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LDP65_RS03510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LDP65_RS03520	COG0288	reversible hydration of carbon dioxide
LDP65_RS03525	COG0659	secondary active sulfate transmembrane transporter activity
LDP65_RS03530	COG1131	(ABC) transporter
LDP65_RS03535	COG0842	Transport permease protein
LDP65_RS03545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LDP65_RS03550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LDP65_RS03560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDP65_RS03565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LDP65_RS03575	COG1643	Atp-dependent helicase
LDP65_RS03580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDP65_RS03585	COG1752	Esterase of the alpha-beta hydrolase superfamily
LDP65_RS03590	COG1049	propionate catabolic process, 2-methylcitrate cycle
LDP65_RS03605	COG0004	ammonium transporteR
LDP65_RS03610	COG1840	ABC-type Fe3 transport system, periplasmic component
LDP65_RS03620	COG3842	ATPase activity
LDP65_RS03625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDP65_RS03640	COG2971	BadF BadG BcrA BcrD
LDP65_RS03650	COG4608	Belongs to the ABC transporter superfamily
LDP65_RS03655	COG0444	Belongs to the ABC transporter superfamily
LDP65_RS03660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDP65_RS03670	COG0747	negative chemotaxis
LDP65_RS03675	COG0784	Response regulator, receiver
LDP65_RS03675	COG2205	protein histidine kinase activity
LDP65_RS03680	COG2813	Specifically methylates the guanine in position
LDP65_RS03685	COG0628	permease
LDP65_RS03710	COG0739	heme binding
LDP65_RS03715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LDP65_RS03730	COG2027	D-alanyl-D-alanine carboxypeptidase
LDP65_RS03735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LDP65_RS03740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDP65_RS03745	COG1534	Rna-binding protein
LDP65_RS03750	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LDP65_RS03755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDP65_RS03760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LDP65_RS03770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDP65_RS03785	COG0779	Required for maturation of 30S ribosomal subunits
LDP65_RS03790	COG0195	Participates in both transcription termination and antitermination
LDP65_RS03795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LDP65_RS03800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LDP65_RS03805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LDP65_RS03810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LDP65_RS03815	COG1185	polyribonucleotide nucleotidyltransferase activity
LDP65_RS03825	COG0826	peptidase U32
LDP65_RS03830	COG0826	peptidase U32
LDP65_RS03840	COG3154	lipid carrier protein
LDP65_RS03845	COG3153	acetyltransferase
LDP65_RS03900	COG1737	Transcriptional regulator
LDP65_RS03905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LDP65_RS03910	COG0022	dehydrogenase e1 component
LDP65_RS03915	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDP65_RS03925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDP65_RS03935	COG1129	ABC transporter
LDP65_RS03950	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS03965	COG1063	alcohol dehydrogenase
LDP65_RS03975	COG0084	hydrolase, TatD family'
LDP65_RS03980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LDP65_RS03990	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LDP65_RS03995	COG0813	purine-nucleoside phosphorylase activity
LDP65_RS04005	COG0560	Phosphoserine phosphatase
LDP65_RS04015	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LDP65_RS04045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDP65_RS04060	COG0583	DNA-binding transcription factor activity
LDP65_RS04070	COG0583	DNA-binding transcription factor activity
LDP65_RS04080	COG1022	Amp-dependent synthetase and ligase
LDP65_RS04095	COG0784	Response regulator, receiver
LDP65_RS04095	COG3437	response regulator, receiver
LDP65_RS04100	COG2059	Chromate
LDP65_RS04145	COG1929	Belongs to the glycerate kinase type-1 family
LDP65_RS04150	COG2610	gluconate transmembrane transporter activity
LDP65_RS04155	COG3835	regulator
LDP65_RS04185	COG2258	MOSC domain
LDP65_RS04205	COG2171	N-acyltransferase activity
LDP65_RS04210	COG3141	response to X-ray
LDP65_RS04215	COG0583	DNA-binding transcription factor activity
LDP65_RS04230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LDP65_RS04235	COG1074	ATP-dependent DNA helicase activity
LDP65_RS04240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDP65_RS04260	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LDP65_RS04265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LDP65_RS04270	COG2166	iron-sulfur cluster assembly
LDP65_RS04280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDP65_RS04285	COG0693	protein deglycase activity
LDP65_RS04290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LDP65_RS04305	COG1595	DNA-templated transcription, initiation
LDP65_RS04315	COG2211	Major facilitator Superfamily
LDP65_RS04320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LDP65_RS04330	COG2813	Specifically methylates the guanine in position
LDP65_RS04335	COG0271	Belongs to the BolA IbaG family
LDP65_RS04340	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LDP65_RS04350	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LDP65_RS04355	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LDP65_RS04360	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LDP65_RS04365	COG2871	sodium ion transport
LDP65_RS04370	COG1477	protein flavinylation
LDP65_RS04390	COG1360	Flagellar Motor Protein
LDP65_RS04415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDP65_RS04435	COG3325	Belongs to the glycosyl hydrolase 18 family
LDP65_RS04435	COG3469	chitinase activity
LDP65_RS04440	COG0733	neurotransmitter:sodium symporter activity
LDP65_RS04465	COG1720	tRNA m6t6A37 methyltransferase activity
LDP65_RS04470	COG0254	rRNA binding
LDP65_RS04480	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LDP65_RS04490	COG2217	Heavy metal translocating P-type atpase
LDP65_RS04490	COG2608	mercury ion transmembrane transporter activity
LDP65_RS04510	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LDP65_RS04560	COG0835	chemotaxis
LDP65_RS04560	COG0784	Response regulator, receiver
LDP65_RS04565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LDP65_RS04570	COG1815	bacterial-type flagellum-dependent cell motility
LDP65_RS04575	COG1558	bacterial-type flagellum-dependent cell motility
LDP65_RS04585	COG1749	Flagellar hook protein flgE
LDP65_RS04590	COG4786	Flagellar basal body rod
LDP65_RS04605	COG1706	bacterial-type flagellum-dependent cell motility
LDP65_RS04610	COG3951	Flagellar rod assembly protein muramidase FlgJ
LDP65_RS04610	COG1705	Flagellar rod assembly protein muramidase FlgJ
LDP65_RS04620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LDP65_RS04630	COG2190	(PTS) system
LDP65_RS04640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDP65_RS04650	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
LDP65_RS04670	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LDP65_RS04675	COG0789	Transcriptional regulator
LDP65_RS04685	COG0330	HflC and HflK could
LDP65_RS04690	COG3118	belongs to the thioredoxin family
LDP65_RS04695	COG0300	oxidoreductase activity
LDP65_RS04700	COG1090	epimerase
LDP65_RS04725	COG0622	Phosphoesterase
LDP65_RS04745	COG3710	Transcriptional regulator
LDP65_RS04750	COG0326	Molecular chaperone. Has ATPase activity
LDP65_RS04760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LDP65_RS04765	COG0250	Participates in transcription elongation, termination and antitermination
LDP65_RS04770	COG0367	asparagine synthase
LDP65_RS04775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDP65_RS04775	COG4651	solute:proton antiporter activity
LDP65_RS04780	COG1846	Transcriptional regulator
LDP65_RS04780	COG1940	carbohydrate kinase activity
LDP65_RS04785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LDP65_RS04790	COG0363	glucosamine-6-phosphate deaminase activity
LDP65_RS04795	COG1263	PTS System
LDP65_RS04795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDP65_RS04795	COG2190	(PTS) system
LDP65_RS04800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDP65_RS04810	COG2963	transposase activity
LDP65_RS04815	COG0735	belongs to the Fur family
LDP65_RS04825	COG0716	FMN binding
LDP65_RS04835	COG0596	Alpha beta hydrolase
LDP65_RS04840	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LDP65_RS04845	COG0033	Phosphoglucomutase
LDP65_RS04855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDP65_RS04870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LDP65_RS04875	COG1053	succinate dehydrogenase
LDP65_RS04885	COG0567	Dehydrogenase, E1 component
LDP65_RS04890	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDP65_RS04895	COG0045	succinate-CoA ligase (ADP-forming) activity
LDP65_RS04905	COG0859	PFAM glycosyl transferase family 9
LDP65_RS04910	COG1132	(ABC) transporter
LDP65_RS04915	COG0076	glutamate decarboxylase activity
LDP65_RS04935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDP65_RS04940	COG1121	(ABC) transporter
LDP65_RS04945	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LDP65_RS04950	COG0739	heme binding
LDP65_RS04980	COG1560	Kdo2-lipid A biosynthetic process
LDP65_RS05000	COG3102	Protein conserved in bacteria
LDP65_RS05005	COG0788	formyltetrahydrofolate deformylase activity
LDP65_RS05015	COG1199	ATP-dependent helicase activity
LDP65_RS05020	COG1214	PFAM Peptidase M22, glycoprotease
LDP65_RS05035	COG0596	Alpha beta hydrolase
LDP65_RS05040	COG0318	PFAM AMP-dependent synthetase and ligase
LDP65_RS05045	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LDP65_RS05060	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LDP65_RS05065	COG2894	cell division
LDP65_RS05075	COG3100	YcgL domain-containing protein
LDP65_RS05080	COG2951	lytic endotransglycosylase activity
LDP65_RS05085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDP65_RS05105	COG0840	transmembrane signaling receptor activity
LDP65_RS05130	COG1175	transmembrane transport
LDP65_RS05135	COG0395	ABC-type sugar transport system, permease component
LDP65_RS05140	COG3842	ATPase activity
LDP65_RS05160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS05165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDP65_RS05170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS05180	COG0431	NADPH-dependent FMN reductase
LDP65_RS05195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS05205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS05210	COG2204	response regulator
LDP65_RS05220	COG0544	peptidyl-prolyl cis-trans isomerase activity
LDP65_RS05235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LDP65_RS05240	COG0776	regulation of translation
LDP65_RS05245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDP65_RS05250	COG1555	photosystem II stabilization
LDP65_RS05265	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LDP65_RS05270	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LDP65_RS05275	COG0436	Aminotransferase
LDP65_RS05280	COG1169	isochorismate synthase
LDP65_RS05285	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LDP65_RS05325	COG0477	Major facilitator Superfamily
LDP65_RS05340	COG0857	belongs to the CobB CobQ family
LDP65_RS05340	COG0280	phosphate acetyltransferase
LDP65_RS05345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LDP65_RS05350	COG3092	negative regulation of chromosome organization
LDP65_RS05360	COG4120	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS05365	COG1122	ATPase activity
LDP65_RS05370	COG2199	diguanylate cyclase activity
LDP65_RS05370	COG2203	Gaf domain
LDP65_RS05375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LDP65_RS05380	COG0653	protein targeting
LDP65_RS05390	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LDP65_RS05395	COG2186	Transcriptional regulator
LDP65_RS05405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDP65_RS05405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDP65_RS05410	COG0489	protein tyrosine kinase activity
LDP65_RS05415	COG5492	domain, Protein
LDP65_RS05420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LDP65_RS05425	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDP65_RS05430	COG3715	PTS system
LDP65_RS05435	COG3716	PTS system mannose fructose sorbose family IID component
LDP65_RS05440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDP65_RS05440	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDP65_RS05445	COG0730	response to heat
LDP65_RS05455	COG0572	uridine kinase
LDP65_RS05460	COG2982	Protein involved in outer membrane biogenesis
LDP65_RS05470	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LDP65_RS05475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDP65_RS05480	COG3738	Protein conserved in bacteria
LDP65_RS05485	COG0659	secondary active sulfate transmembrane transporter activity
LDP65_RS05490	COG1530	ribonuclease E activity
LDP65_RS05495	COG0564	pseudouridine synthase activity
LDP65_RS05500	COG0424	maF-like protein
LDP65_RS05505	COG1399	metal-binding, possibly nucleic acid-binding protein
LDP65_RS05515	COG0416	fatty acid biosynthetic process
LDP65_RS05520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDP65_RS05525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LDP65_RS05545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDP65_RS05550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LDP65_RS05555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LDP65_RS05565	COG0084	hydrolase, TatD family'
LDP65_RS05570	COG1263	PTS System
LDP65_RS05570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDP65_RS05575	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LDP65_RS05580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDP65_RS05595	COG3721	Heme iron utilization protein
LDP65_RS05600	COG0748	coenzyme F420 binding
LDP65_RS05615	COG0733	neurotransmitter:sodium symporter activity
LDP65_RS05625	COG4667	esterase of the alpha-beta hydrolase superfamily
LDP65_RS05635	COG1940	carbohydrate kinase activity
LDP65_RS05640	COG0784	Response regulator, receiver
LDP65_RS05640	COG0835	chemotaxis
LDP65_RS05645	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS05650	COG0616	signal peptide processing
LDP65_RS05660	COG0539	negative regulation of cytoplasmic translation
LDP65_RS05670	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LDP65_RS05675	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LDP65_RS05720	COG0583	DNA-binding transcription factor activity
LDP65_RS05730	COG0686	Belongs to the AlaDH PNT family
LDP65_RS05745	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LDP65_RS05750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LDP65_RS05760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDP65_RS05770	COG0156	8-amino-7-oxononanoate synthase activity
LDP65_RS05775	COG2226	methyltransferase
LDP65_RS05780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LDP65_RS05790	COG0501	Belongs to the peptidase M48B family
LDP65_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS05815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LDP65_RS05840	COG3923	Primosomal replication protein n
LDP65_RS05845	COG0730	response to heat
LDP65_RS05850	COG1199	ATP-dependent helicase activity
LDP65_RS05855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LDP65_RS05885	COG1757	Na H antiporter
LDP65_RS05900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDP65_RS05905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDP65_RS05910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LDP65_RS05910	COG0131	Imidazoleglycerol-phosphate dehydratase
LDP65_RS05915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LDP65_RS05920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LDP65_RS05930	COG0140	phosphoribosyl-ATP diphosphatase activity
LDP65_RS05930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LDP65_RS05935	COG3012	SEC-C Motif Domain Protein
LDP65_RS05940	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LDP65_RS05945	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDP65_RS05950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LDP65_RS05955	COG0215	cysteine-tRNA ligase activity
LDP65_RS05960	COG1435	thymidine kinase activity
LDP65_RS05975	COG0189	ligase activity
LDP65_RS05975	COG4067	protein conserved in archaea
LDP65_RS05980	COG0500	methyltransferase
LDP65_RS05985	COG4106	trans-aconitate 2-methyltransferase activity
LDP65_RS05990	COG1801	Protein of unknown function DUF72
LDP65_RS06000	COG0217	transcriptional regulatory protein
LDP65_RS06005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LDP65_RS06010	COG0632	four-way junction helicase activity
LDP65_RS06015	COG2255	four-way junction helicase activity
LDP65_RS06020	COG1271	oxidase subunit
LDP65_RS06025	COG1294	oxidase, subunit
LDP65_RS06030	COG4890	Cyd operon protein YbgT
LDP65_RS06040	COG0824	Thioesterase
LDP65_RS06045	COG0811	peptide transport
LDP65_RS06060	COG0823	Involved in the tonB-independent uptake of proteins
LDP65_RS06065	COG2885	chlorophyll binding
LDP65_RS06070	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LDP65_RS06075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LDP65_RS06085	COG0784	Response regulator, receiver
LDP65_RS06085	COG2205	protein histidine kinase activity
LDP65_RS06110	COG1074	ATP-dependent DNA helicase activity
LDP65_RS06125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDP65_RS06135	COG1032	radical SAM domain protein
LDP65_RS06150	COG5001	Diguanylate cyclase
LDP65_RS06165	COG0583	DNA-binding transcription factor activity
LDP65_RS06170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LDP65_RS06180	COG3313	Fe-S protein
LDP65_RS06235	COG2873	o-acetylhomoserine
LDP65_RS06240	COG1522	sequence-specific DNA binding
LDP65_RS06245	COG2205	protein histidine kinase activity
LDP65_RS06275	COG1061	Type III restriction enzyme res subunit
LDP65_RS06285	COG2814	Major facilitator Superfamily
LDP65_RS06295	COG0702	epimerase
LDP65_RS06305	COG4181	ATPase activity
LDP65_RS06325	COG0708	Exodeoxyribonuclease III
LDP65_RS06340	COG1120	ATPase activity
LDP65_RS06350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDP65_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS06390	COG3385	transposase activity
LDP65_RS06400	COG3040	lipid binding
LDP65_RS06430	COG0697	spore germination
LDP65_RS06440	COG3718	enzyme involved in inositol metabolism
LDP65_RS06445	COG0673	inositol 2-dehydrogenase activity
LDP65_RS06470	COG3655	Transcriptional regulator
LDP65_RS06475	COG0673	inositol 2-dehydrogenase activity
LDP65_RS06480	COG0191	fructose-bisphosphate aldolase activity
LDP65_RS06490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDP65_RS06495	COG0673	inositol 2-dehydrogenase activity
LDP65_RS06500	COG3962	Belongs to the TPP enzyme family
LDP65_RS06505	COG1082	Xylose isomerase domain protein TIM barrel
LDP65_RS06510	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS06525	COG1609	Transcriptional regulator
LDP65_RS06565	COG0840	transmembrane signaling receptor activity
LDP65_RS06570	COG2850	peptidyl-arginine hydroxylation
LDP65_RS06585	COG0840	transmembrane signaling receptor activity
LDP65_RS06590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LDP65_RS06615	COG1278	Cold shock
LDP65_RS06620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LDP65_RS06625	COG0542	response to heat
LDP65_RS06635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LDP65_RS06640	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LDP65_RS06645	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LDP65_RS06665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LDP65_RS06675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LDP65_RS06680	COG0297	glycogen (starch) synthase activity
LDP65_RS06685	COG0596	Alpha beta hydrolase
LDP65_RS06695	COG3070	regulator of competence-specific genes
LDP65_RS06710	COG0745	RESPONSE REGULATOR receiver
LDP65_RS06715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LDP65_RS06720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LDP65_RS06725	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LDP65_RS06730	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LDP65_RS06735	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LDP65_RS06775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LDP65_RS06795	COG0784	Response regulator, receiver
LDP65_RS06795	COG2205	protein histidine kinase activity
LDP65_RS06800	COG1858	cytochrome C peroxidase
LDP65_RS06805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDP65_RS06820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LDP65_RS06825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LDP65_RS06835	COG2824	Alkylphosphonate utilization operon protein PhnA
LDP65_RS06855	COG0643	Histidine kinase
LDP65_RS06855	COG2198	Histidine kinase
LDP65_RS06855	COG0784	Response regulator, receiver
LDP65_RS06875	COG0019	diaminopimelate decarboxylase activity
LDP65_RS06880	COG1609	Transcriptional regulator
LDP65_RS06890	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS07015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDP65_RS07020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDP65_RS07035	COG1309	transcriptional regulator
LDP65_RS07050	COG0840	transmembrane signaling receptor activity
LDP65_RS07055	COG5001	Diguanylate cyclase
LDP65_RS07055	COG2203	Gaf domain
LDP65_RS07055	COG4251	negative regulation of phosphorylation
LDP65_RS07055	COG3706	GGDEF domain
LDP65_RS07065	COG0784	Response regulator, receiver
LDP65_RS07065	COG2205	protein histidine kinase activity
LDP65_RS07065	COG5002	protein histidine kinase activity
LDP65_RS07075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDP65_RS07100	COG2989	Protein conserved in bacteria
LDP65_RS07105	COG3108	Peptidase M15
LDP65_RS07110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDP65_RS07125	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDP65_RS07145	COG2197	response regulator
LDP65_RS07150	COG1846	Transcriptional regulator
LDP65_RS07155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LDP65_RS07160	COG2176	DNA-directed DNA polymerase activity
LDP65_RS07165	COG0517	IMP dehydrogenase activity
LDP65_RS07170	COG1448	Aminotransferase
LDP65_RS07175	COG3437	response regulator, receiver
LDP65_RS07175	COG2770	Histidine kinase
LDP65_RS07180	COG0017	Asparaginyl-tRNA synthetase
LDP65_RS07185	COG0840	transmembrane signaling receptor activity
LDP65_RS07200	COG0720	synthase
LDP65_RS07210	COG1760	l-serine dehydratase
LDP65_RS07215	COG0814	amino acid
LDP65_RS07220	COG0494	nUDIX hydrolase
LDP65_RS07230	COG0784	Response regulator, receiver
LDP65_RS07230	COG2205	protein histidine kinase activity
LDP65_RS07230	COG2198	Histidine kinase
LDP65_RS07250	COG3106	COG3106 Predicted ATPase
LDP65_RS07255	COG3768	UPF0283 membrane protein
LDP65_RS07265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDP65_RS07290	COG0840	transmembrane signaling receptor activity
LDP65_RS07300	COG1454	alcohol dehydrogenase
LDP65_RS07315	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
LDP65_RS07350	COG0443	Heat shock 70 kDa protein
LDP65_RS07355	COG0443	Heat shock 70 kDa protein
LDP65_RS07365	COG3706	GGDEF domain
LDP65_RS07380	COG2304	oxidoreductase activity
LDP65_RS07410	COG2801	Transposase and inactivated derivatives
LDP65_RS07500	COG1082	Xylose isomerase domain protein TIM barrel
LDP65_RS07500	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LDP65_RS07505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LDP65_RS07515	COG1802	Transcriptional regulator
LDP65_RS07520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS07525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDP65_RS07530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS07540	COG2828	Protein conserved in bacteria
LDP65_RS07555	COG2159	amidohydrolase
LDP65_RS07575	COG0667	Aldo Keto reductase
LDP65_RS07605	COG4628	conserved protein (DUF2132)
LDP65_RS07625	COG2721	sulfolactate sulfo-lyase activity
LDP65_RS07635	COG2188	Transcriptional regulator
LDP65_RS07640	COG1063	alcohol dehydrogenase
LDP65_RS07645	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS07650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDP65_RS07655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS07655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDP65_RS07660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDP65_RS07675	COG1609	Transcriptional regulator
LDP65_RS07680	COG0583	DNA-binding transcription factor activity
LDP65_RS07695	COG4964	Belongs to the GSP D family
LDP65_RS07745	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LDP65_RS07745	COG2885	chlorophyll binding
LDP65_RS07760	COG2186	Transcriptional regulator
LDP65_RS07765	COG3842	ATPase activity
LDP65_RS07775	COG1175	transmembrane transport
LDP65_RS07780	COG0395	ABC-type sugar transport system, permease component
LDP65_RS07785	COG2706	6-phosphogluconolactonase activity
LDP65_RS07795	COG1070	Carbohydrate kinase
LDP65_RS07805	COG3623	hexulose-6-phosphate isomerase
LDP65_RS07810	COG0235	Class ii aldolase
LDP65_RS07820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LDP65_RS07825	COG1643	Atp-dependent helicase
LDP65_RS07870	COG0300	oxidoreductase activity
LDP65_RS07870	COG0318	PFAM AMP-dependent synthetase and ligase
LDP65_RS07870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDP65_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS07870	COG3321	synthase
LDP65_RS07885	COG3300	MHYT domain
LDP65_RS07885	COG5001	Diguanylate cyclase
LDP65_RS07890	COG3622	Belongs to the hyi family
LDP65_RS07895	COG1115	amino acid carrier protein
LDP65_RS07900	COG0277	FAD linked oxidase domain protein
LDP65_RS07905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDP65_RS07905	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
LDP65_RS07915	COG2801	Transposase and inactivated derivatives
LDP65_RS07920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDP65_RS07940	COG4821	SIS domain
LDP65_RS07945	COG4753	response regulator
LDP65_RS07945	COG2207	Transcriptional regulator
LDP65_RS07970	COG1115	amino acid carrier protein
LDP65_RS07975	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS08000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDP65_RS08010	COG3290	protein histidine kinase activity
LDP65_RS08015	COG4565	transcriptional regulatory protein
LDP65_RS08055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LDP65_RS08060	COG0372	Belongs to the citrate synthase family
LDP65_RS08065	COG2079	MmgE PrpD family protein
LDP65_RS08085	COG0602	queuosine metabolic process
LDP65_RS08095	COG3706	GGDEF domain
LDP65_RS08175	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS08190	COG4176	ABC-type proline glycine betaine transport system permease component
LDP65_RS08195	COG4175	Glycine betaine
LDP65_RS08195	COG3448	diguanylate cyclase activity
LDP65_RS08205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDP65_RS08210	COG1760	l-serine dehydratase
LDP65_RS08240	COG1063	alcohol dehydrogenase
LDP65_RS08255	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDP65_RS08255	COG1902	pentaerythritol trinitrate reductase activity
LDP65_RS08260	COG0247	lactate metabolic process
LDP65_RS08260	COG2181	nitrate reductase activity
LDP65_RS08265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LDP65_RS08290	COG1785	Belongs to the alkaline phosphatase family
LDP65_RS08325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDP65_RS08345	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LDP65_RS08345	COG3291	Pkd domain containing protein
LDP65_RS08350	COG0702	epimerase
LDP65_RS08355	COG1280	lysine exporter protein (LysE YggA)
LDP65_RS08360	COG0840	transmembrane signaling receptor activity
LDP65_RS08365	COG5002	protein histidine kinase activity
LDP65_RS08365	COG2205	protein histidine kinase activity
LDP65_RS08365	COG0784	Response regulator, receiver
LDP65_RS08370	COG0745	RESPONSE REGULATOR receiver
LDP65_RS08375	COG2199	diguanylate cyclase activity
LDP65_RS08375	COG2200	EAL domain
LDP65_RS08375	COG2203	Gaf domain
LDP65_RS08380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDP65_RS08385	COG1215	transferase activity, transferring glycosyl groups
LDP65_RS08390	COG0438	transferase activity, transferring glycosyl groups
LDP65_RS08400	COG0438	transferase activity, transferring glycosyl groups
LDP65_RS08405	COG0110	maltose O-acetyltransferase activity
LDP65_RS08415	COG0438	transferase activity, transferring glycosyl groups
LDP65_RS08420	COG0438	transferase activity, transferring glycosyl groups
LDP65_RS08425	COG2204	response regulator
LDP65_RS08430	COG3437	response regulator, receiver
LDP65_RS08430	COG3850	Histidine kinase
LDP65_RS08430	COG4999	Histidine kinase
LDP65_RS08430	COG2205	protein histidine kinase activity
LDP65_RS08435	COG0745	RESPONSE REGULATOR receiver
LDP65_RS08440	COG0489	protein tyrosine kinase activity
LDP65_RS08465	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LDP65_RS08470	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LDP65_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS08485	COG1164	Oligoendopeptidase f
LDP65_RS08495	COG4139	cobalamin transport
LDP65_RS08500	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LDP65_RS08560	COG0513	Belongs to the DEAD box helicase family
LDP65_RS08575	COG0583	DNA-binding transcription factor activity
LDP65_RS08585	COG1366	Belongs to the anti-sigma-factor antagonist family
LDP65_RS08590	COG1366	Belongs to the anti-sigma-factor antagonist family
LDP65_RS08595	COG2172	sigma factor antagonist activity
LDP65_RS08605	COG4999	Histidine kinase
LDP65_RS08605	COG3850	Histidine kinase
LDP65_RS08605	COG3437	response regulator, receiver
LDP65_RS08605	COG2205	protein histidine kinase activity
LDP65_RS08610	COG3437	response regulator, receiver
LDP65_RS08625	COG1451	nucleotide metabolic process
LDP65_RS08645	COG0840	transmembrane signaling receptor activity
LDP65_RS08725	COG2195	Cleaves the N-terminal amino acid of tripeptides
LDP65_RS08740	COG2199	diguanylate cyclase activity
LDP65_RS08755	COG2200	EAL domain
LDP65_RS08755	COG2199	diguanylate cyclase activity
LDP65_RS08775	COG0724	RNA recognition motif
LDP65_RS08785	COG1793	dna ligase
LDP65_RS08795	COG0534	Mate efflux family protein
LDP65_RS08800	COG0307	riboflavin synthase, alpha
LDP65_RS08810	COG3001	Fructosamine kinase
LDP65_RS08820	COG3706	GGDEF domain
LDP65_RS08830	COG0791	NLP P60 protein
LDP65_RS08845	COG3148	PFAM DTW domain containing protein
LDP65_RS08850	COG1940	carbohydrate kinase activity
LDP65_RS08855	COG2204	response regulator
LDP65_RS08860	COG3852	Histidine kinase
LDP65_RS08870	COG1858	cytochrome C peroxidase
LDP65_RS08875	COG1858	cytochrome C peroxidase
LDP65_RS08880	COG0723	plastoquinol--plastocyanin reductase activity
LDP65_RS08900	COG0303	'Molybdopterin
LDP65_RS08905	COG0746	molybdenum cofactor guanylyltransferase activity
LDP65_RS08910	COG3842	ATPase activity
LDP65_RS08915	COG4662	Binding-protein-dependent transport system inner membrane component
LDP65_RS08925	COG2204	response regulator
LDP65_RS08930	COG3852	Histidine kinase
LDP65_RS08935	COG0488	(ABC) transporter
LDP65_RS08945	COG1175	transmembrane transport
LDP65_RS08950	COG0395	ABC-type sugar transport system, permease component
LDP65_RS08955	COG3842	ATPase activity
LDP65_RS08960	COG0246	Mannitol dehydrogenase
LDP65_RS08970	COG1070	Carbohydrate kinase
LDP65_RS08980	COG0840	transmembrane signaling receptor activity
LDP65_RS08995	COG0456	acetyltransferase
LDP65_RS09015	COG0840	transmembrane signaling receptor activity
LDP65_RS09020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LDP65_RS09050	COG3383	formate dehydrogenase (NAD+) activity
LDP65_RS09050	COG0243	molybdopterin cofactor binding
LDP65_RS09055	COG0437	4 iron, 4 sulfur cluster binding
LDP65_RS09060	COG2864	formate dehydrogenase
LDP65_RS09065	COG5002	protein histidine kinase activity
LDP65_RS09070	COG0004	ammonium transporteR
LDP65_RS09075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LDP65_RS09080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LDP65_RS09090	COG1177	transmembrane transport
LDP65_RS09100	COG3842	ATPase activity
LDP65_RS09125	COG1486	melibiose metabolic process
LDP65_RS09130	COG0037	tRNA processing
LDP65_RS09135	COG0589	response to stress
LDP65_RS09140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDP65_RS09155	COG2217	Heavy metal translocating P-type atpase
LDP65_RS09165	COG2010	Cytochrome c
LDP65_RS09180	COG3278	Belongs to the heme-copper respiratory oxidase family
LDP65_RS09195	COG0784	Response regulator, receiver
LDP65_RS09195	COG2205	protein histidine kinase activity
LDP65_RS09210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDP65_RS09220	COG3568	Endonuclease Exonuclease Phosphatase
LDP65_RS09235	COG3120	sequence-specific DNA binding
LDP65_RS09240	COG1067	ATP-dependent peptidase activity
LDP65_RS09245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDP65_RS09260	COG0488	(ABC) transporter
LDP65_RS09270	COG0116	Belongs to the methyltransferase superfamily
LDP65_RS09270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LDP65_RS09280	COG0167	dihydroorotate dehydrogenase activity
LDP65_RS09285	COG2902	Dehydrogenase
LDP65_RS09295	COG0308	aminopeptidase N
LDP65_RS09310	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LDP65_RS09315	COG1956	GAF domain-containing protein
LDP65_RS09320	COG1132	(ABC) transporter
LDP65_RS09325	COG2995	paraquat-inducible protein a
LDP65_RS09330	COG3008	intermembrane lipid transfer
LDP65_RS09335	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LDP65_RS09335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LDP65_RS09355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDP65_RS09360	COG1666	GTP binding
LDP65_RS09365	COG1648	precorrin-2 dehydrogenase activity
LDP65_RS09365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDP65_RS09370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDP65_RS09375	COG4597	amino acid ABC transporter
LDP65_RS09380	COG0765	amino acid transport
LDP65_RS09385	COG1126	abc transporter atp-binding protein
LDP65_RS09390	COG0670	Belongs to the BI1 family
LDP65_RS09395	COG2920	part of a sulfur-relay system
LDP65_RS09400	COG1254	Belongs to the acylphosphatase family
LDP65_RS09505	COG0631	protein serine/threonine phosphatase activity
LDP65_RS09540	COG2815	serine threonine protein kinase
LDP65_RS09540	COG0515	serine threonine protein kinase
LDP65_RS09550	COG3706	GGDEF domain
LDP65_RS09560	COG2010	Cytochrome c
LDP65_RS09570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LDP65_RS09575	COG1309	transcriptional regulator
LDP65_RS09600	COG2925	Exonuclease
LDP65_RS09605	COG1380	Effector of murein hydrolase LrgA
LDP65_RS09610	COG1346	cytolysis
LDP65_RS09620	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LDP65_RS09635	COG0500	methyltransferase
LDP65_RS09650	COG0776	regulation of translation
LDP65_RS09660	COG1136	(ABC) transporter
LDP65_RS09680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDP65_RS09680	COG0072	phenylalanine-tRNA ligase activity
LDP65_RS09710	COG2133	pyrroloquinoline quinone binding
LDP65_RS09730	COG2350	Protein conserved in bacteria
LDP65_RS09740	COG4134	Bacterial extracellular solute-binding protein
LDP65_RS09745	COG4135	transport system, permease component
LDP65_RS09750	COG4136	ATPase activity
LDP65_RS09755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDP65_RS09775	COG0300	oxidoreductase activity
LDP65_RS09780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDP65_RS09785	COG2207	Transcriptional regulator
LDP65_RS09790	COG0351	phosphomethylpyrimidine kinase
LDP65_RS09795	COG1116	anion transmembrane transporter activity
LDP65_RS09800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDP65_RS09805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LDP65_RS09810	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LDP65_RS09815	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LDP65_RS09885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LDP65_RS09885	COG0116	Belongs to the methyltransferase superfamily
LDP65_RS09890	COG0564	pseudouridine synthase activity
LDP65_RS09900	COG0733	neurotransmitter:sodium symporter activity
LDP65_RS09910	COG0626	cystathionine gamma-synthase activity
LDP65_RS09915	COG0519	Catalyzes the synthesis of GMP from XMP
LDP65_RS09945	COG1842	Phage shock protein A
LDP65_RS09950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LDP65_RS09960	COG4168	peptide transport system, permease
LDP65_RS09965	COG4171	peptide transport system, permease
LDP65_RS09975	COG4172	Belongs to the ABC transporter superfamily
LDP65_RS10025	COG0519	Catalyzes the synthesis of GMP from XMP
LDP65_RS10030	COG0745	RESPONSE REGULATOR receiver
LDP65_RS10040	COG2190	(PTS) system
LDP65_RS10040	COG1263	PTS System
LDP65_RS10040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDP65_RS10045	COG0840	transmembrane signaling receptor activity
LDP65_RS10060	COG1227	inorganic diphosphatase activity
LDP65_RS10065	COG0167	dihydroorotate dehydrogenase activity
LDP65_RS10080	COG0243	molybdopterin cofactor binding
LDP65_RS10085	COG3005	denitrification pathway
LDP65_RS10090	COG4459	periplasmic nitrate reductase
LDP65_RS10095	COG0390	transport system, permease component
LDP65_RS10100	COG2202	Pas domain
LDP65_RS10100	COG2205	protein histidine kinase activity
LDP65_RS10130	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
LDP65_RS10135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LDP65_RS10145	COG3901	Regulator of nitric oxide reductase transcription
LDP65_RS10145	COG0348	domain, Protein
LDP65_RS10185	COG1129	ABC transporter
LDP65_RS10185	COG0842	Transport permease protein
LDP65_RS10205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDP65_RS10210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LDP65_RS10240	COG3706	GGDEF domain
LDP65_RS10250	COG0322	excinuclease ABC activity
LDP65_RS10255	COG2197	response regulator
LDP65_RS10260	COG0417	DNA replication proofreading
LDP65_RS10270	COG4067	protein conserved in archaea
LDP65_RS10270	COG0189	ligase activity
LDP65_RS10275	COG0189	ligase activity
LDP65_RS10285	COG1760	l-serine dehydratase
LDP65_RS10290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LDP65_RS10320	COG0009	L-threonylcarbamoyladenylate synthase
LDP65_RS10325	COG0613	PHP domain protein
LDP65_RS10335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LDP65_RS10340	COG0512	Glutamine amidotransferase of anthranilate synthase
LDP65_RS10345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDP65_RS10350	COG0135	phosphoribosylanthranilate isomerase activity
LDP65_RS10350	COG0134	indole-3-glycerol-phosphate synthase activity
LDP65_RS10355	COG0133	tryptophan synthase activity
LDP65_RS10360	COG0159	tryptophan synthase activity
LDP65_RS10370	COG1301	dicarboxylic acid transport
LDP65_RS10510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDP65_RS10630	COG3421	Type III restriction
LDP65_RS10635	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LDP65_RS10755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LDP65_RS10760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LDP65_RS10785	COG0596	Alpha beta hydrolase
LDP65_RS10785	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDP65_RS10835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDP65_RS10840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LDP65_RS10850	COG4948	Mandelate Racemase Muconate Lactonizing
LDP65_RS10855	COG2721	sulfolactate sulfo-lyase activity
LDP65_RS10865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDP65_RS10870	COG3842	ATPase activity
LDP65_RS10875	COG0395	ABC-type sugar transport system, permease component
LDP65_RS10880	COG1175	transmembrane transport
LDP65_RS10890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDP65_RS10910	COG0673	inositol 2-dehydrogenase activity
LDP65_RS10940	COG0183	Belongs to the thiolase family
LDP65_RS10975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDP65_RS10980	COG0247	lactate metabolic process
LDP65_RS10980	COG2181	nitrate reductase activity
LDP65_RS10985	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LDP65_RS10990	COG2086	electron transfer activity
LDP65_RS11050	COG0488	(ABC) transporter
LDP65_RS11065	COG4948	Mandelate Racemase Muconate Lactonizing
LDP65_RS11070	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDP65_RS11085	COG3618	amidohydrolase
LDP65_RS11100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS11105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LDP65_RS11110	COG0363	glucosamine-6-phosphate deaminase activity
LDP65_RS11125	COG0246	Mannitol dehydrogenase
LDP65_RS11140	COG1609	Transcriptional regulator
LDP65_RS11145	COG3842	ATPase activity
LDP65_RS11150	COG0366	Alpha amylase catalytic
LDP65_RS11155	COG0395	ABC-type sugar transport system, permease component
LDP65_RS11160	COG1175	transmembrane transport
LDP65_RS11165	COG1653	transport
LDP65_RS11170	COG2188	Transcriptional regulator
LDP65_RS11180	COG0010	Belongs to the arginase family
LDP65_RS11185	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LDP65_RS11190	COG2986	histidine ammonia-lyase
LDP65_RS11200	COG3706	GGDEF domain
LDP65_RS11215	COG0277	FAD linked oxidase domain protein
LDP65_RS11215	COG0247	lactate metabolic process
LDP65_RS11250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LDP65_RS11255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDP65_RS11260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDP65_RS11285	COG2267	carboxylic ester hydrolase activity
LDP65_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS11305	COG0454	-acetyltransferase
LDP65_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS11315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LDP65_RS11325	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
LDP65_RS11330	COG1643	Atp-dependent helicase
LDP65_RS11335	COG0281	malic enzyme
LDP65_RS11345	COG2949	membrane
LDP65_RS11370	COG0492	ferredoxin-NADP+ reductase activity
LDP65_RS11375	COG4988	ABC transporter
LDP65_RS11380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LDP65_RS11385	COG1879	ABC-type sugar transport system periplasmic component
LDP65_RS11415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LDP65_RS11440	COG4608	Belongs to the ABC transporter superfamily
LDP65_RS11445	COG0444	Belongs to the ABC transporter superfamily
LDP65_RS11450	COG4166	transmembrane transport
LDP65_RS11455	COG4239	(ABC) transporter, permease
LDP65_RS11460	COG4174	ABC transporter (Permease)
LDP65_RS11465	COG3070	regulator of competence-specific genes
LDP65_RS11485	COG0076	glutamate decarboxylase activity
LDP65_RS11490	COG1737	Transcriptional regulator
LDP65_RS11495	COG1454	alcohol dehydrogenase
LDP65_RS11500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LDP65_RS11515	COG1960	acyl-CoA dehydrogenase activity
LDP65_RS11520	COG1309	transcriptional regulator
LDP65_RS11565	COG1882	Formate acetyltransferase
LDP65_RS11580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LDP65_RS11590	COG3013	Belongs to the UPF0304 family
LDP65_RS11595	COG2766	serine protein kinase
LDP65_RS11600	COG2718	Belongs to the UPF0229 family
LDP65_RS11605	COG2719	SpoVR family
LDP65_RS11625	COG0463	Glycosyl transferase, family 2
LDP65_RS11640	COG2835	tetraacyldisaccharide 4'-kinase activity
LDP65_RS11645	COG1663	tetraacyldisaccharide 4'-kinase activity
LDP65_RS11650	COG1132	(ABC) transporter
LDP65_RS11655	COG0658	competence protein
LDP65_RS11655	COG2333	competence protein COMEC
LDP65_RS11665	COG4591	ABC-type transport system involved in lipoprotein release permease component
LDP65_RS11670	COG1136	(ABC) transporter
LDP65_RS11675	COG4591	ABC-type transport system involved in lipoprotein release permease component
LDP65_RS11685	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LDP65_RS11700	COG1252	NADH dehydrogenase
LDP65_RS11705	COG2165	general secretion pathway protein
LDP65_RS11735	COG0537	adenosine 5'-monophosphoramidase activity
LDP65_RS11740	COG0840	transmembrane signaling receptor activity
LDP65_RS11765	COG4191	Histidine kinase
LDP65_RS11765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDP65_RS11770	COG0471	metal ion transport
LDP65_RS11785	COG5001	Diguanylate cyclase
LDP65_RS11785	COG1716	ATPase activity
LDP65_RS11790	COG0835	chemotaxis
LDP65_RS11790	COG0784	Response regulator, receiver
LDP65_RS11800	COG2205	protein histidine kinase activity
LDP65_RS11805	COG0745	RESPONSE REGULATOR receiver
LDP65_RS11815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDP65_RS11820	COG1079	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS11825	COG4603	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS11830	COG3845	ABC transporter
LDP65_RS11835	COG1744	ABC transporter substrate-binding protein PnrA-like
LDP65_RS11845	COG0784	Response regulator, receiver
LDP65_RS11845	COG2205	protein histidine kinase activity
LDP65_RS11860	COG3246	L-lysine catabolic process to acetate
LDP65_RS11865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDP65_RS11945	COG0657	acetylesterase activity
LDP65_RS11965	COG3321	synthase
LDP65_RS11965	COG0604	alcohol dehydrogenase
LDP65_RS11970	COG0583	DNA-binding transcription factor activity
LDP65_RS11980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDP65_RS11985	COG1845	cytochrome c oxidase, subunit III
LDP65_RS11990	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LDP65_RS11995	COG0109	protoheme IX farnesyltransferase activity
LDP65_RS12050	COG0438	transferase activity, transferring glycosyl groups
LDP65_RS12100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDP65_RS12115	COG0242	peptide deformylase activity
LDP65_RS12120	COG2226	methyltransferase
LDP65_RS12150	COG2199	diguanylate cyclase activity
LDP65_RS12165	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LDP65_RS12170	COG1946	Acyl-CoA thioesterase
LDP65_RS12175	COG1522	sequence-specific DNA binding
LDP65_RS12225	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LDP65_RS12240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LDP65_RS12250	COG0574	Belongs to the PEP-utilizing enzyme family
LDP65_RS12250	COG3848	Pyruvate phosphate dikinase
LDP65_RS12285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDP65_RS12290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDP65_RS12325	COG2963	transposase activity
LDP65_RS12330	COG0435	Glutathione S-transferase
LDP65_RS12350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDP65_RS12355	COG0601	transmembrane transport
LDP65_RS12370	COG0314	molybdopterin synthase activity
LDP65_RS12375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LDP65_RS12385	COG0521	Mo-molybdopterin cofactor biosynthetic process
LDP65_RS12390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LDP65_RS12395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LDP65_RS12400	COG2198	Histidine kinase
LDP65_RS12405	COG2204	response regulator
LDP65_RS12410	COG0556	nucleotide-excision repair
LDP65_RS12460	COG4657	Part of a membrane complex involved in electron transport
LDP65_RS12470	COG4656	Part of a membrane complex involved in electron transport
LDP65_RS12475	COG4658	electron transport chain
LDP65_RS12480	COG4659	FMN binding
LDP65_RS12485	COG4660	Part of a membrane complex involved in electron transport
LDP65_RS12490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LDP65_RS12495	COG4172	Belongs to the ABC transporter superfamily
LDP65_RS12505	COG0601	transmembrane transport
LDP65_RS12510	COG0747	negative chemotaxis
LDP65_RS12515	COG0346	lactoylglutathione lyase activity
LDP65_RS12525	COG2885	chlorophyll binding
LDP65_RS12530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LDP65_RS12535	COG2056	Na+-H+ antiporter family
LDP65_RS12540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LDP65_RS12570	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS12570	COG1454	alcohol dehydrogenase
LDP65_RS12575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDP65_RS12585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LDP65_RS12590	COG0643	Histidine kinase
LDP65_RS12590	COG2198	Histidine kinase
LDP65_RS12600	COG3082	Protein of unknown function (DUF1414)
LDP65_RS12865	COG5377	YqaJ viral recombinase family
LDP65_RS12885	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDP65_RS12885	COG0596	Alpha beta hydrolase
LDP65_RS12890	COG0022	dehydrogenase e1 component
LDP65_RS12895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LDP65_RS12900	COG3199	ATP-NAD kinase
LDP65_RS12905	COG3284	Transcriptional regulator
LDP65_RS12915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LDP65_RS12940	COG2258	MOSC domain
LDP65_RS12950	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LDP65_RS12985	COG0123	including yeast histone deacetylase and acetoin utilization protein
LDP65_RS13000	COG1473	amidohydrolase
LDP65_RS13015	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS13025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDP65_RS13025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDP65_RS13030	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LDP65_RS13035	COG0583	DNA-binding transcription factor activity
LDP65_RS13040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LDP65_RS13045	COG0778	Nitroreductase
LDP65_RS13050	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDP65_RS13050	COG1902	pentaerythritol trinitrate reductase activity
LDP65_RS13055	COG0616	signal peptide processing
LDP65_RS13060	COG0252	asparaginase activity
LDP65_RS13065	COG3139	Protein of unknown function (DUF1315)
LDP65_RS13080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LDP65_RS13085	COG0676	glucose-6-phosphate 1-epimerase activity
LDP65_RS13090	COG0745	RESPONSE REGULATOR receiver
LDP65_RS13095	COG2205	protein histidine kinase activity
LDP65_RS13110	COG2226	methyltransferase
LDP65_RS13130	COG1120	ATPase activity
LDP65_RS13135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LDP65_RS13160	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS13175	COG4176	ABC-type proline glycine betaine transport system permease component
LDP65_RS13180	COG3448	diguanylate cyclase activity
LDP65_RS13180	COG4175	Glycine betaine
LDP65_RS13205	COG2983	Belongs to the UPF0260 family
LDP65_RS13230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LDP65_RS13235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LDP65_RS13245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LDP65_RS13250	COG2832	Protein of unknown function (DUF454)
LDP65_RS13260	COG0745	RESPONSE REGULATOR receiver
LDP65_RS13270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LDP65_RS13275	COG1286	toxin biosynthetic process
LDP65_RS13280	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LDP65_RS13285	COG0285	dihydrofolate synthase activity
LDP65_RS13295	COG0101	tRNA pseudouridine synthase activity
LDP65_RS13305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LDP65_RS13310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDP65_RS13325	COG0745	RESPONSE REGULATOR receiver
LDP65_RS13330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDP65_RS13355	COG3101	peptidyl-lysine hydroxylation
LDP65_RS13360	COG2860	membrane
LDP65_RS13365	COG4221	oxidoreductase activity
LDP65_RS13370	COG0583	DNA-binding transcription factor activity
LDP65_RS13375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LDP65_RS13380	COG2890	protein-(glutamine-N5) methyltransferase activity
LDP65_RS13385	COG2840	Smr protein MutS2
LDP65_RS13390	COG2062	phosphohistidine phosphatase, SixA
LDP65_RS13400	COG0366	Alpha amylase catalytic
LDP65_RS13400	COG1470	cell adhesion involved in biofilm formation
LDP65_RS13405	COG0667	Aldo Keto reductase
LDP65_RS13410	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS13415	COG1129	ABC transporter
LDP65_RS13435	COG1349	DNA-binding transcription factor activity
LDP65_RS13440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LDP65_RS13445	COG1070	Carbohydrate kinase
LDP65_RS13460	COG0183	Belongs to the thiolase family
LDP65_RS13465	COG1595	DNA-templated transcription, initiation
LDP65_RS13475	COG2067	long-chain fatty acid transport protein
LDP65_RS13480	COG5265	(ABC) transporter
LDP65_RS13485	COG2853	Lipoprotein
LDP65_RS13490	COG3088	subunit of a heme lyase
LDP65_RS13490	COG4235	cytochrome complex assembly
LDP65_RS13495	COG4235	cytochrome complex assembly
LDP65_RS13495	COG3088	subunit of a heme lyase
LDP65_RS13500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDP65_RS13505	COG1138	Cytochrome C-type biogenesis protein
LDP65_RS13510	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LDP65_RS13515	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDP65_RS13520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDP65_RS13525	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDP65_RS13530	COG4133	protoheme IX ABC transporter activity
LDP65_RS13540	COG0835	chemotaxis
LDP65_RS13550	COG1192	Involved in chromosome partitioning
LDP65_RS13560	COG0643	Histidine kinase
LDP65_RS13560	COG0784	Response regulator, receiver
LDP65_RS13560	COG2198	Histidine kinase
LDP65_RS13565	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LDP65_RS13605	COG1987	bacterial-type flagellum assembly
LDP65_RS13655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LDP65_RS13665	COG1677	Flagellar hook-basal body complex protein FliE
LDP65_RS13685	COG1516	flagellar protein fliS
LDP65_RS13695	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LDP65_RS13700	COG1334	flagellar protein FlaG
LDP65_RS13705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LDP65_RS13715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LDP65_RS13720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LDP65_RS13725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LDP65_RS13730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LDP65_RS13735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LDP65_RS13755	COG2837	iron assimilation
LDP65_RS13780	COG1393	Belongs to the ArsC family
LDP65_RS13790	COG1876	peptidase activity
LDP65_RS13800	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LDP65_RS13805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDP65_RS13815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LDP65_RS13830	COG4783	chaperone-mediated protein folding
LDP65_RS13835	COG1393	Belongs to the ArsC family
LDP65_RS13855	COG2233	PERMEase
LDP65_RS13870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDP65_RS13885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LDP65_RS13890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LDP65_RS13895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LDP65_RS13905	COG3473	Maleate cis-trans isomerase
LDP65_RS13910	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDP65_RS13930	COG0410	ABC transporter
LDP65_RS13935	COG0411	ABC transporter
LDP65_RS13975	COG0121	glutamine amidotransferase
LDP65_RS13980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LDP65_RS13985	COG1960	acyl-CoA dehydrogenase activity
LDP65_RS14000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LDP65_RS14010	COG2226	methyltransferase
LDP65_RS14015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDP65_RS14020	COG0741	lytic transglycosylase activity
LDP65_RS14020	COG1388	LysM domain
LDP65_RS14035	COG0347	Belongs to the P(II) protein family
LDP65_RS14055	COG0825	malonyl-CoA metabolic process
LDP65_RS14060	COG0587	DNA-directed DNA polymerase activity
LDP65_RS14065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDP65_RS14080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDP65_RS14090	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LDP65_RS14095	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDP65_RS14100	COG0750	zinc metalloprotease
LDP65_RS14105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LDP65_RS14110	COG0575	Belongs to the CDS family
LDP65_RS14115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDP65_RS14140	COG0024	Methionine aminopeptidase
LDP65_RS14155	COG0564	pseudouridine synthase activity
LDP65_RS14160	COG3098	single-species biofilm formation
LDP65_RS14190	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LDP65_RS14200	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LDP65_RS14200	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LDP65_RS14215	COG1611	Belongs to the LOG family
LDP65_RS14235	COG2363	Small membrane protein
LDP65_RS14245	COG0583	DNA-binding transcription factor activity
LDP65_RS14250	COG3152	Membrane
LDP65_RS14255	COG0301	tRNA thio-modification
LDP65_RS14255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDP65_RS14265	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LDP65_RS14270	COG1722	exodeoxyribonuclease VII activity
LDP65_RS14275	COG0142	geranyltranstransferase activity
LDP65_RS14280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDP65_RS14290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LDP65_RS14300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDP65_RS14320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDP65_RS14320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDP65_RS14325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDP65_RS14330	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LDP65_RS14345	COG1073	alpha beta
LDP65_RS14350	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LDP65_RS14355	COG2252	PERMEase
LDP65_RS14360	COG2195	Cleaves the N-terminal amino acid of tripeptides
LDP65_RS14370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDP65_RS14370	COG0047	phosphoribosylformylglycinamidine synthase activity
LDP65_RS14375	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LDP65_RS14385	COG0583	DNA-binding transcription factor activity
LDP65_RS14400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LDP65_RS14420	COG4969	Belongs to the N-Me-Phe pilin family
LDP65_RS14430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LDP65_RS14435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LDP65_RS14440	COG0497	DNA recombination
LDP65_RS14445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDP65_RS14450	COG2914	Belongs to the UPF0125 (RnfH) family
LDP65_RS14455	COG2867	negative regulation of translational initiation
LDP65_RS14470	COG1396	sequence-specific DNA binding
LDP65_RS14485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LDP65_RS14505	COG0095	Lipoate-protein ligase
LDP65_RS14515	COG1842	Phage shock protein A
LDP65_RS14540	COG0754	glutathionylspermidine amidase activity
LDP65_RS14580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDP65_RS14605	COG0351	phosphomethylpyrimidine kinase
LDP65_RS14625	COG1187	pseudouridine synthase activity
LDP65_RS14630	COG2840	Smr protein MutS2
LDP65_RS14660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LDP65_RS14665	COG2912	Transglutaminase-like superfamily
LDP65_RS14675	COG2890	protein-(glutamine-N5) methyltransferase activity
LDP65_RS14680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LDP65_RS14685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LDP65_RS14690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LDP65_RS14700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LDP65_RS14705	COG0193	aminoacyl-tRNA hydrolase activity
LDP65_RS14790	COG2706	6-phosphogluconolactonase activity
LDP65_RS14795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDP65_RS14815	COG0395	ABC-type sugar transport system, permease component
LDP65_RS14820	COG1024	Enoyl-CoA hydratase
LDP65_RS14825	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS14835	COG3842	ATPase activity
LDP65_RS14845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDP65_RS14855	COG1702	phosphate starvation-inducible protein PhoH
LDP65_RS14865	COG4535	Mg2 and Co2 transporter CorC
LDP65_RS14870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LDP65_RS14880	COG2888	peptidyl-tyrosine sulfation
LDP65_RS14885	COG0495	leucyl-tRNA aminoacylation
LDP65_RS14890	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LDP65_RS14895	COG1466	dna polymerase III delta subunit
LDP65_RS14900	COG0799	negative regulation of ribosome biogenesis
LDP65_RS14905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LDP65_RS14910	COG0768	penicillin binding
LDP65_RS14915	COG0772	Belongs to the SEDS family
LDP65_RS14920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LDP65_RS14925	COG1686	Belongs to the peptidase S11 family
LDP65_RS14935	COG0321	lipoyl(octanoyl) transferase activity
LDP65_RS14940	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDP65_RS14950	COG0484	heat shock protein binding
LDP65_RS14960	COG1301	dicarboxylic acid transport
LDP65_RS14975	COG0366	Alpha amylase catalytic
LDP65_RS14980	COG1263	PTS System
LDP65_RS14980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDP65_RS14985	COG1609	Transcriptional regulator
LDP65_RS14995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LDP65_RS15005	COG2011	ABC-type metal ion transport system permease component
LDP65_RS15010	COG1464	Belongs to the NlpA lipoprotein family
LDP65_RS15015	COG1737	Transcriptional regulator
LDP65_RS15020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDP65_RS15025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDP65_RS15030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS15035	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDP65_RS15040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS15050	COG1940	carbohydrate kinase activity
LDP65_RS15055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LDP65_RS15060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDP65_RS15075	COG4948	Mandelate Racemase Muconate Lactonizing
LDP65_RS15090	COG2188	Transcriptional regulator
LDP65_RS15095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS15105	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDP65_RS15105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS15110	COG2186	Transcriptional regulator
LDP65_RS15115	COG2205	protein histidine kinase activity
LDP65_RS15115	COG4999	Histidine kinase
LDP65_RS15115	COG3850	Histidine kinase
LDP65_RS15115	COG3437	response regulator, receiver
LDP65_RS15130	COG2200	EAL domain
LDP65_RS15150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDP65_RS15155	COG1115	amino acid carrier protein
LDP65_RS15160	COG1584	GPR1 FUN34 yaaH family protein
LDP65_RS15165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDP65_RS15165	COG0519	Catalyzes the synthesis of GMP from XMP
LDP65_RS15170	COG0516	GMP reductase activity
LDP65_RS15170	COG0517	IMP dehydrogenase activity
LDP65_RS15185	COG1160	GTP binding
LDP65_RS15190	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDP65_RS15195	COG2976	Protein conserved in bacteria
LDP65_RS15200	COG0124	histidyl-tRNA synthetase
LDP65_RS15210	COG1426	Protein conserved in bacteria
LDP65_RS15215	COG3063	Type IV pilus biogenesis stability protein PilW
LDP65_RS15225	COG0105	UTP biosynthetic process
LDP65_RS15235	COG2975	iron-sulfur cluster assembly
LDP65_RS15240	COG0633	Ferredoxin
LDP65_RS15260	COG0822	iron-sulfur transferase activity
LDP65_RS15265	COG1104	cysteine desulfurase activity
LDP65_RS15275	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LDP65_RS15280	COG0483	inositol monophosphate 1-phosphatase activity
LDP65_RS15285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDP65_RS15290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDP65_RS15295	COG1862	Preprotein translocase
LDP65_RS15300	COG0343	queuine tRNA-ribosyltransferase activity
LDP65_RS15305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LDP65_RS15315	COG0517	IMP dehydrogenase activity
LDP65_RS15330	COG0583	DNA-binding transcription factor activity
LDP65_RS15335	COG0450	alkyl hydroperoxide reductase
LDP65_RS15340	COG3142	Participates in the control of copper homeostasis
LDP65_RS15355	COG0704	Plays a role in the regulation of phosphate uptake
LDP65_RS15360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LDP65_RS15365	COG0581	inorganic phosphate transmembrane transporter activity
LDP65_RS15370	COG0573	inorganic phosphate transmembrane transporter activity
LDP65_RS15375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LDP65_RS15380	COG0248	Ppx GppA phosphatase
LDP65_RS15390	COG5002	protein histidine kinase activity
LDP65_RS15395	COG0745	RESPONSE REGULATOR receiver
LDP65_RS15410	COG0826	peptidase U32
LDP65_RS15415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDP65_RS15435	COG0848	biopolymer transport protein
LDP65_RS15440	COG0811	peptide transport
LDP65_RS15445	COG0811	peptide transport
LDP65_RS15490	COG0542	response to heat
LDP65_RS15500	COG0564	pseudouridine synthase activity
LDP65_RS15505	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDP65_RS15510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDP65_RS15515	COG0077	Prephenate dehydratase
LDP65_RS15515	COG1605	Chorismate mutase
LDP65_RS15520	COG5001	Diguanylate cyclase
LDP65_RS15525	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LDP65_RS15530	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
LDP65_RS15540	COG0488	(ABC) transporter
LDP65_RS15550	COG0739	heme binding
LDP65_RS15555	COG0287	Prephenate dehydrogenase
LDP65_RS15555	COG1605	Chorismate mutase
LDP65_RS15560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDP65_RS15565	COG3275	phosphorelay sensor kinase activity
LDP65_RS15570	COG3279	Response regulator of the LytR AlgR family
LDP65_RS15580	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LDP65_RS15585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LDP65_RS15600	COG1966	Carbon starvation protein
LDP65_RS15610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LDP65_RS15615	COG1047	Peptidyl-prolyl cis-trans
LDP65_RS15620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LDP65_RS15630	COG0196	riboflavin kinase activity
LDP65_RS15635	COG0728	peptidoglycan biosynthetic process
LDP65_RS15640	COG0268	Binds directly to 16S ribosomal RNA
LDP65_RS15645	COG0640	Transcriptional regulator
LDP65_RS15650	COG0583	DNA-binding transcription factor activity
LDP65_RS15655	COG1283	sodium-dependent phosphate transmembrane transporter activity
LDP65_RS15660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LDP65_RS15665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LDP65_RS15670	COG0730	response to heat
LDP65_RS15680	COG0494	nUDIX hydrolase
LDP65_RS15695	COG0667	Aldo Keto reductase
LDP65_RS15705	COG2204	response regulator
LDP65_RS15710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LDP65_RS15720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LDP65_RS15725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDP65_RS15730	COG4974	Belongs to the 'phage' integrase family
LDP65_RS15735	COG0716	FMN binding
LDP65_RS15750	COG0513	Belongs to the DEAD box helicase family
LDP65_RS15755	COG1737	Transcriptional regulator
LDP65_RS15765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS15770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS15780	COG3842	ATPase activity
LDP65_RS15785	COG0395	ABC-type sugar transport system, permease component
LDP65_RS15790	COG1175	transmembrane transport
LDP65_RS15795	COG2182	Extracellular solute-binding protein
LDP65_RS15800	COG1940	carbohydrate kinase activity
LDP65_RS15810	COG3022	response to hydroperoxide
LDP65_RS15815	COG1115	amino acid carrier protein
LDP65_RS15830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LDP65_RS15840	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
LDP65_RS15845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LDP65_RS15850	COG0083	homoserine kinase activity
LDP65_RS15865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDP65_RS15875	COG0745	RESPONSE REGULATOR receiver
LDP65_RS15885	COG0784	Response regulator, receiver
LDP65_RS15885	COG5002	protein histidine kinase activity
LDP65_RS15885	COG2198	Histidine kinase
LDP65_RS15890	COG3706	GGDEF domain
LDP65_RS15890	COG2203	Gaf domain
LDP65_RS15890	COG4251	negative regulation of phosphorylation
LDP65_RS15890	COG5001	Diguanylate cyclase
LDP65_RS15895	COG1242	4 iron, 4 sulfur cluster binding
LDP65_RS15900	COG0067	glutamate synthase
LDP65_RS15900	COG0070	glutamate synthase
LDP65_RS15900	COG0069	glutamate synthase activity
LDP65_RS15910	COG0069	glutamate synthase activity
LDP65_RS15910	COG0070	glutamate synthase
LDP65_RS15910	COG0067	glutamate synthase
LDP65_RS15915	COG0493	'glutamate synthase
LDP65_RS15940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LDP65_RS15945	COG2860	membrane
LDP65_RS15960	COG0655	NAD(P)H dehydrogenase (quinone) activity
LDP65_RS15970	COG0814	amino acid
LDP65_RS15985	COG1119	ATPase activity
LDP65_RS15990	COG1522	sequence-specific DNA binding
LDP65_RS15990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDP65_RS15995	COG2313	pseudouridylate synthase activity
LDP65_RS16020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LDP65_RS16025	COG0505	Belongs to the CarA family
LDP65_RS16045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LDP65_RS16050	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LDP65_RS16055	COG0849	cell division
LDP65_RS16060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LDP65_RS16070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDP65_RS16075	COG0772	Belongs to the SEDS family
LDP65_RS16080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LDP65_RS16085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDP65_RS16090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDP65_RS16100	COG0768	penicillin binding
LDP65_RS16105	COG3116	cell division
LDP65_RS16120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LDP65_RS16125	COG3107	peptidoglycan biosynthetic process
LDP65_RS16130	COG0792	nuclease activity
LDP65_RS16135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LDP65_RS16140	COG2823	Periplasmic or secreted lipoprotein
LDP65_RS16145	COG2969	positive regulation of protein catabolic process
LDP65_RS16150	COG0625	glutathione transferase activity
LDP65_RS16155	COG2857	Cytochrome c1
LDP65_RS16160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LDP65_RS16165	COG0723	plastoquinol--plastocyanin reductase activity
LDP65_RS16170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LDP65_RS16180	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LDP65_RS16185	COG3105	Protein conserved in bacteria
LDP65_RS16190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDP65_RS16195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDP65_RS16210	COG3150	esterase
LDP65_RS16220	COG3151	Protein conserved in bacteria
LDP65_RS16225	COG0494	nUDIX hydrolase
LDP65_RS16230	COG1538	Outer membrane efflux protein
LDP65_RS16235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LDP65_RS16235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LDP65_RS16240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LDP65_RS16250	COG3025	triphosphatase activity
LDP65_RS16255	COG1392	Phosphate transport regulator
LDP65_RS16260	COG0306	phosphate transporter
LDP65_RS16265	COG4991	sh3 domain protein
LDP65_RS16275	COG3409	Peptidoglycan-binding domain 1 protein
LDP65_RS16275	COG3267	Type II secretory pathway component ExeA
LDP65_RS16280	COG0617	tRNA 3'-terminal CCA addition
LDP65_RS16295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDP65_RS16300	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDP65_RS16305	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LDP65_RS16310	COG2186	Transcriptional regulator
LDP65_RS16320	COG0157	Belongs to the NadC ModD family
LDP65_RS16330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LDP65_RS16335	COG1459	type II secretion system
LDP65_RS16350	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LDP65_RS16355	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LDP65_RS16360	COG0494	nUDIX hydrolase
LDP65_RS16370	COG0336	Belongs to the RNA methyltransferase TrmD family
LDP65_RS16385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LDP65_RS16390	COG4137	Cytochrome C assembly protein
LDP65_RS16395	COG4536	flavin adenine dinucleotide binding
LDP65_RS16405	COG1854	S-ribosylhomocysteine lyase activity
LDP65_RS16420	COG0612	Peptidase, M16
LDP65_RS16425	COG1238	metal cluster binding
LDP65_RS16435	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
LDP65_RS16440	COG0511	ligase activity, forming carbon-carbon bonds
LDP65_RS16440	COG5016	pyruvate
LDP65_RS16445	COG3630	sodium ion export across plasma membrane
LDP65_RS16490	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LDP65_RS16495	COG0527	aspartate kinase activity
LDP65_RS16500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDP65_RS16505	COG2137	regulation of response to DNA damage stimulus
LDP65_RS16510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LDP65_RS16515	COG1546	Belongs to the CinA family
LDP65_RS16520	COG3853	Toxic anion resistance protein (TelA)
LDP65_RS16530	COG2255	four-way junction helicase activity
LDP65_RS16555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDP65_RS16570	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LDP65_RS16575	COG0585	pseudouridine synthase activity
LDP65_RS16585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LDP65_RS16590	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LDP65_RS16605	COG3956	TIGRFAM MazG family protein
LDP65_RS16610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDP65_RS16615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDP65_RS16620	COG4999	Histidine kinase
LDP65_RS16620	COG2205	protein histidine kinase activity
LDP65_RS16620	COG3437	response regulator, receiver
LDP65_RS16620	COG3850	Histidine kinase
LDP65_RS16645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LDP65_RS16650	COG1381	Involved in DNA repair and RecF pathway recombination
LDP65_RS16655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LDP65_RS16660	COG0571	ribonuclease III activity
LDP65_RS16665	COG0681	Belongs to the peptidase S26 family
LDP65_RS16685	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LDP65_RS16690	COG1595	DNA-templated transcription, initiation
LDP65_RS16695	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LDP65_RS16725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDP65_RS16730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDP65_RS16735	COG3079	Belongs to the UPF0149 family
LDP65_RS16740	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LDP65_RS16750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LDP65_RS16760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDP65_RS16775	COG1279	arginine transmembrane transporter activity
LDP65_RS16785	COG0668	transmembrane transport
LDP65_RS16790	COG0191	fructose-bisphosphate aldolase activity
LDP65_RS16800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LDP65_RS16810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LDP65_RS16815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LDP65_RS16830	COG2356	endonuclease I
LDP65_RS16835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDP65_RS16840	COG0189	ligase activity
LDP65_RS16845	COG1678	Uncharacterized ACR, COG1678
LDP65_RS16850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LDP65_RS16865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LDP65_RS16870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LDP65_RS16875	COG0762	integral membrane protein
LDP65_RS16890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LDP65_RS16895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDP65_RS16900	COG2066	Belongs to the glutaminase family
LDP65_RS16910	COG1194	a g-specific adenine glycosylase
LDP65_RS16920	COG0741	lytic transglycosylase activity
LDP65_RS17010	COG0175	sulfate reduction
LDP65_RS17020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LDP65_RS17045	COG0582	viral genome integration into host DNA
LDP65_RS17070	COG1715	Restriction endonuclease
LDP65_RS17075	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LDP65_RS17080	COG0732	type I restriction modification DNA specificity domain
LDP65_RS17085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LDP65_RS17140	COG0735	belongs to the Fur family
LDP65_RS17155	COG0432	Pfam Uncharacterised protein family UPF0047
LDP65_RS17165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDP65_RS17185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LDP65_RS17190	COG2965	DNA replication, synthesis of RNA primer
LDP65_RS17195	COG0360	Binds together with S18 to 16S ribosomal RNA
LDP65_RS17205	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS17215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDP65_RS17245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LDP65_RS17245	COG2070	2-Nitropropane dioxygenase
LDP65_RS17250	COG2207	Transcriptional regulator
LDP65_RS17255	COG4771	TonB-dependent receptor
LDP65_RS17260	COG1132	(ABC) transporter
LDP65_RS17260	COG2375	cellular response to nickel ion
LDP65_RS17265	COG1132	(ABC) transporter
LDP65_RS17280	COG3433	isochorismatase activity
LDP65_RS17280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDP65_RS17280	COG2226	methyltransferase
LDP65_RS17285	COG1021	2,3-dihydroxybenzoate-AMP ligase
LDP65_RS17335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDP65_RS17345	COG0583	DNA-binding transcription factor activity
LDP65_RS17355	COG0180	Tryptophanyl-tRNA synthetase
LDP65_RS17360	COG0546	phosphoglycolate phosphatase activity
LDP65_RS17365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDP65_RS17370	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LDP65_RS17380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LDP65_RS17415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LDP65_RS17425	COG0678	peroxiredoxin activity
LDP65_RS17425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LDP65_RS17430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDP65_RS17445	COG0165	Argininosuccinate lyase
LDP65_RS17445	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LDP65_RS17450	COG0137	argininosuccinate synthase activity
LDP65_RS17455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDP65_RS17460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LDP65_RS17465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDP65_RS17470	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LDP65_RS17480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LDP65_RS17485	COG0460	homoserine dehydrogenase
LDP65_RS17485	COG0527	aspartate kinase activity
LDP65_RS17490	COG0626	cystathionine gamma-synthase activity
LDP65_RS17495	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LDP65_RS17500	COG0281	malic enzyme
LDP65_RS17510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LDP65_RS17515	COG1609	Transcriptional regulator
LDP65_RS17525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LDP65_RS17535	COG1575	Belongs to the MenA family. Type 1 subfamily
LDP65_RS17545	COG3074	FtsZ-dependent cytokinesis
LDP65_RS17550	COG1494	fructose-1,6-bisphosphatase
LDP65_RS17565	COG3152	Membrane
LDP65_RS17575	COG0149	triose-phosphate isomerase activity
LDP65_RS17580	COG1414	Transcriptional regulator
LDP65_RS17610	COG1045	serine acetyltransferase
LDP65_RS17615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LDP65_RS17620	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LDP65_RS17625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDP65_RS17630	COG2373	Large extracellular alpha-helical protein
LDP65_RS17635	COG4953	penicillin-binding protein 1C
LDP65_RS17645	COG4942	peptidase
LDP65_RS17660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDP65_RS17690	COG1216	Glycosyl transferase, family 2
LDP65_RS17695	COG1132	(ABC) transporter
LDP65_RS17730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDP65_RS17745	COG1482	cell wall glycoprotein biosynthetic process
LDP65_RS17770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDP65_RS17775	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LDP65_RS17855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDP65_RS17865	COG0726	polysaccharide deacetylase
LDP65_RS17870	COG0859	PFAM glycosyl transferase family 9
LDP65_RS17875	COG1519	Transferase
LDP65_RS17895	COG1216	Glycosyl transferase, family 2
LDP65_RS17900	COG3642	lipopolysaccharide core region biosynthetic process
LDP65_RS17905	COG0859	PFAM glycosyl transferase family 9
LDP65_RS17910	COG0463	Glycosyl transferase, family 2
LDP65_RS17915	COG0859	PFAM glycosyl transferase family 9
LDP65_RS17920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LDP65_RS17925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDP65_RS17940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LDP65_RS17945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LDP65_RS17950	COG2003	Belongs to the UPF0758 family
LDP65_RS17955	COG1858	cytochrome C peroxidase
LDP65_RS17960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LDP65_RS17965	COG1309	transcriptional regulator
LDP65_RS17970	COG1560	Kdo2-lipid A biosynthetic process
LDP65_RS17975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LDP65_RS17980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LDP65_RS17985	COG1561	YicC-like family, N-terminal region
LDP65_RS17995	COG0194	GDP metabolic process
LDP65_RS18000	COG1758	RNA polymerase activity
LDP65_RS18005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDP65_RS18010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDP65_RS18030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDP65_RS18040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LDP65_RS18060	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LDP65_RS18065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDP65_RS18070	COG2183	response to ionizing radiation
LDP65_RS18075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LDP65_RS18080	COG3161	chorismate lyase activity
LDP65_RS18090	COG0705	Rhomboid family
LDP65_RS18105	COG2177	Part of the ABC transporter FtsEX involved in
LDP65_RS18110	COG2884	Cell division ATP-binding protein ftsE
LDP65_RS18115	COG0552	protein localization to endoplasmic reticulum
LDP65_RS18120	COG0742	ribosomal rna small subunit methyltransferase
LDP65_RS18130	COG2095	MarC family integral membrane protein
LDP65_RS18155	COG3274	enterobacterial common antigen metabolic process
LDP65_RS18160	COG4221	oxidoreductase activity
LDP65_RS18165	COG0583	DNA-binding transcription factor activity
LDP65_RS18170	COG0783	Belongs to the Dps family
LDP65_RS18175	COG1609	Transcriptional regulator
LDP65_RS18180	COG1840	ABC-type Fe3 transport system, periplasmic component
LDP65_RS18190	COG3842	ATPase activity
LDP65_RS18195	COG0483	inositol monophosphate 1-phosphatase activity
LDP65_RS18210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LDP65_RS18215	COG0640	Transcriptional regulator
LDP65_RS18220	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LDP65_RS18225	COG1280	lysine exporter protein (LysE YggA)
LDP65_RS18235	COG0561	phosphatase activity
LDP65_RS18250	COG3148	PFAM DTW domain containing protein
LDP65_RS18260	COG2199	diguanylate cyclase activity
LDP65_RS18260	COG2200	EAL domain
LDP65_RS18260	COG3287	FIST C domain
LDP65_RS18265	COG1011	Hydrolase
LDP65_RS18270	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LDP65_RS18280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LDP65_RS18285	COG0019	diaminopimelate decarboxylase activity
LDP65_RS18300	COG3072	Adenylate cyclase
LDP65_RS18310	COG1587	Uroporphyrinogen-III synthase
LDP65_RS18315	COG2959	enzyme of heme biosynthesis
LDP65_RS18320	COG3071	HemY protein
LDP65_RS18395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LDP65_RS18410	COG3118	belongs to the thioredoxin family
LDP65_RS18420	COG0248	Ppx GppA phosphatase
LDP65_RS18430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS18435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS18445	COG2188	Transcriptional regulator
LDP65_RS18450	COG0673	inositol 2-dehydrogenase activity
LDP65_RS18460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LDP65_RS18470	COG0514	ATP-dependent DNA helicase (RecQ)
LDP65_RS18475	COG2962	Rard protein
LDP65_RS18485	COG1280	lysine exporter protein (LysE YggA)
LDP65_RS18490	COG0405	Gamma-glutamyltransferase
LDP65_RS18495	COG0210	DNA helicase
LDP65_RS18505	COG3220	belongs to the UPF0276 family
LDP65_RS18545	COG0006	proline dipeptidase activity
LDP65_RS18555	COG2022	thiamine diphosphate biosynthetic process
LDP65_RS18565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LDP65_RS18575	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LDP65_RS18580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDP65_RS18625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LDP65_RS18635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDP65_RS18640	COG0408	coproporphyrinogen oxidase activity
LDP65_RS18645	COG0009	L-threonylcarbamoyladenylate synthase
LDP65_RS18650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LDP65_RS18655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LDP65_RS18660	COG0551	DNA topoisomerase type I activity
LDP65_RS18665	COG2922	Belongs to the Smg family
LDP65_RS18670	COG0758	DNA mediated transformation
LDP65_RS18675	COG1652	LysM domain
LDP65_RS18680	COG0242	peptide deformylase activity
LDP65_RS18690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDP65_RS18690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LDP65_RS18695	COG0569	domain protein
LDP65_RS18700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDP65_RS18705	COG1272	protein, Hemolysin III
LDP65_RS18710	COG4326	sporulation control protein
LDP65_RS18715	COG3084	Protein conserved in bacteria
LDP65_RS18725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LDP65_RS18730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDP65_RS18735	COG0204	Acyl-transferase
LDP65_RS18745	COG0606	chelatase, subunit chli
LDP65_RS18755	COG3978	acetolactate synthase activity
LDP65_RS18760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDP65_RS18775	COG0583	DNA-binding transcription factor activity
LDP65_RS18780	COG2814	Major facilitator Superfamily
LDP65_RS18785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDP65_RS18790	COG0765	amino acid transport
LDP65_RS18800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LDP65_RS18810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LDP65_RS18815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LDP65_RS18820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDP65_RS18835	COG0356	it plays a direct role in the translocation of protons across the membrane
LDP65_RS18840	COG3312	ion transport
LDP65_RS18845	COG1475	DNA binding
LDP65_RS18850	COG1192	Involved in chromosome partitioning
LDP65_RS18855	COG0357	Ribosomal RNA small subunit methyltransferase G
LDP65_RS18860	COG0445	tRNA wobble uridine modification
LDP65_RS18865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LDP65_RS18875	COG0848	biopolymer transport protein
LDP65_RS18885	COG4783	chaperone-mediated protein folding
LDP65_RS18910	COG3712	iron ion homeostasis
LDP65_RS18915	COG1595	DNA-templated transcription, initiation
LDP65_RS18925	COG0706	membrane insertase activity
LDP65_RS18935	COG0594	ribonuclease P activity
LDP65_RS18940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LDP65_RS18945	COG1126	abc transporter atp-binding protein
LDP65_RS18970	COG4608	Belongs to the ABC transporter superfamily
LDP65_RS18975	COG0444	Belongs to the ABC transporter superfamily
LDP65_RS19005	COG0789	Transcriptional regulator
LDP65_RS19020	COG2264	protein methyltransferase activity
LDP65_RS19035	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS19055	COG1129	ABC transporter
LDP65_RS19060	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS19065	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS19090	COG0601	transmembrane transport
LDP65_RS19095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDP65_RS19100	COG0444	Belongs to the ABC transporter superfamily
LDP65_RS19105	COG4172	Belongs to the ABC transporter superfamily
LDP65_RS19130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDP65_RS19140	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS19185	COG2199	diguanylate cyclase activity
LDP65_RS19185	COG2200	EAL domain
LDP65_RS19195	COG0316	Belongs to the HesB IscA family
LDP65_RS19200	COG0719	Fe-S assembly protein
LDP65_RS19205	COG0396	ATPase activity
LDP65_RS19210	COG0719	Fe-S assembly protein
LDP65_RS19220	COG2166	iron-sulfur cluster assembly
LDP65_RS19235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDP65_RS19250	COG1070	Carbohydrate kinase
LDP65_RS19260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LDP65_RS19265	COG0667	Aldo Keto reductase
LDP65_RS19275	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS19280	COG1129	ABC transporter
LDP65_RS19290	COG1454	alcohol dehydrogenase
LDP65_RS19300	COG1414	Transcriptional regulator
LDP65_RS19305	COG3437	response regulator, receiver
LDP65_RS19310	COG2205	protein histidine kinase activity
LDP65_RS19310	COG3437	response regulator, receiver
LDP65_RS19310	COG4999	Histidine kinase
LDP65_RS19310	COG3850	Histidine kinase
LDP65_RS19320	COG2311	Membrane
LDP65_RS19390	COG3706	GGDEF domain
LDP65_RS19395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDP65_RS19405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDP65_RS19410	COG0800	Aldolase
LDP65_RS19425	COG5001	Diguanylate cyclase
LDP65_RS19430	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS19435	COG3284	Transcriptional regulator
LDP65_RS19440	COG0583	DNA-binding transcription factor activity
LDP65_RS19445	COG2814	Major facilitator Superfamily
LDP65_RS19450	COG3706	GGDEF domain
LDP65_RS19450	COG2203	Gaf domain
LDP65_RS19450	COG5001	Diguanylate cyclase
LDP65_RS19450	COG4251	negative regulation of phosphorylation
LDP65_RS19540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDP65_RS19555	COG1979	alcohol dehydrogenase
LDP65_RS19560	COG0583	DNA-binding transcription factor activity
LDP65_RS19575	COG4172	Belongs to the ABC transporter superfamily
LDP65_RS19610	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS19625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDP65_RS19630	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS19635	COG3384	dioxygenase
LDP65_RS19665	COG3971	2-oxopent-4-enoate hydratase activity
LDP65_RS19675	COG1960	acyl-CoA dehydrogenase activity
LDP65_RS19695	COG1067	ATP-dependent peptidase activity
LDP65_RS19710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDP65_RS19725	COG2814	Major facilitator Superfamily
LDP65_RS19775	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS19810	COG0840	transmembrane signaling receptor activity
LDP65_RS19815	COG1846	Transcriptional regulator
LDP65_RS19835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS19835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDP65_RS19840	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDP65_RS19845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS19875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDP65_RS19880	COG2999	glutathione oxidoreductase activity
LDP65_RS19895	COG1278	Cold shock
LDP65_RS19915	COG4452	Inner membrane protein CreD
LDP65_RS19920	COG2205	protein histidine kinase activity
LDP65_RS19925	COG0745	RESPONSE REGULATOR receiver
LDP65_RS19930	COG0730	response to heat
LDP65_RS19935	COG0280	phosphate acetyltransferase
LDP65_RS19940	COG1414	Transcriptional regulator
LDP65_RS19945	COG2188	Transcriptional regulator
LDP65_RS19955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDP65_RS19965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDP65_RS19965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDP65_RS19970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDP65_RS19980	COG2205	protein histidine kinase activity
LDP65_RS19985	COG0745	RESPONSE REGULATOR receiver
LDP65_RS19995	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LDP65_RS20000	COG0534	Mate efflux family protein
LDP65_RS20005	COG0583	DNA-binding transcription factor activity
LDP65_RS20015	COG2962	Rard protein
LDP65_RS20030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LDP65_RS20040	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS20050	COG0583	DNA-binding transcription factor activity
LDP65_RS20060	COG0583	DNA-binding transcription factor activity
LDP65_RS20070	COG0573	inorganic phosphate transmembrane transporter activity
LDP65_RS20075	COG0581	inorganic phosphate transmembrane transporter activity
LDP65_RS20080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LDP65_RS20090	COG0395	ABC-type sugar transport system, permease component
LDP65_RS20095	COG1175	transmembrane transport
LDP65_RS20105	COG3842	ATPase activity
LDP65_RS20115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDP65_RS20125	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS20130	COG1609	Transcriptional regulator
LDP65_RS20170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDP65_RS20175	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDP65_RS20185	COG0789	Transcriptional regulator
LDP65_RS20210	COG2814	Major facilitator Superfamily
LDP65_RS20215	COG0583	DNA-binding transcription factor activity
LDP65_RS20220	COG0523	cobalamin synthesis protein
LDP65_RS20235	COG3485	protocatechuate 3,4-dioxygenase
LDP65_RS20245	COG0725	ABC transporter, periplasmic molybdate-binding protein
LDP65_RS20250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LDP65_RS20275	COG1349	DNA-binding transcription factor activity
LDP65_RS20300	COG0612	Peptidase, M16
LDP65_RS20320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDP65_RS20355	COG3135	benzoate transporter
LDP65_RS20360	COG1396	sequence-specific DNA binding
LDP65_RS20400	COG2205	protein histidine kinase activity
LDP65_RS20410	COG1404	Belongs to the peptidase S8 family
LDP65_RS20490	COG0215	cysteine-tRNA ligase activity
LDP65_RS20495	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LDP65_RS20505	COG1404	Belongs to the peptidase S8 family
LDP65_RS20510	COG0443	Heat shock 70 kDa protein
LDP65_RS20525	COG2207	Transcriptional regulator
LDP65_RS20550	COG2132	Multicopper oxidase
LDP65_RS20555	COG3122	Protein conserved in bacteria
LDP65_RS20580	COG0402	S-adenosylhomocysteine deaminase activity
LDP65_RS20585	COG2197	response regulator
LDP65_RS20600	COG2755	lipolytic protein G-D-S-L family
LDP65_RS20600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LDP65_RS20615	COG0473	3-isopropylmalate dehydrogenase activity
LDP65_RS20620	COG0583	DNA-binding transcription factor activity
LDP65_RS20640	COG0789	Transcriptional regulator
LDP65_RS20660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDP65_RS20675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LDP65_RS20690	COG2197	response regulator
LDP65_RS20710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDP65_RS20715	COG4585	Histidine kinase
LDP65_RS20745	COG3501	Rhs element vgr protein
LDP65_RS20800	COG3209	COG3209 Rhs family protein
LDP65_RS20815	COG3501	Rhs element vgr protein
LDP65_RS20870	COG3501	Rhs element vgr protein
LDP65_RS20930	COG3829	transcription factor binding
LDP65_RS20960	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LDP65_RS21005	COG1215	transferase activity, transferring glycosyl groups
LDP65_RS21015	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LDP65_RS21040	COG1215	transferase activity, transferring glycosyl groups
LDP65_RS21050	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LDP65_RS21060	COG1073	alpha beta
LDP65_RS21075	COG1278	Cold shock
LDP65_RS21100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDP65_RS21135	COG3852	Histidine kinase
LDP65_RS21140	COG0583	DNA-binding transcription factor activity
LDP65_RS21160	COG2249	NAD(P)H dehydrogenase (quinone) activity
LDP65_RS21165	COG1357	PFAM Pentapeptide repeats (8 copies)
LDP65_RS21170	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS21175	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LDP65_RS21190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS21195	COG2186	Transcriptional regulator
LDP65_RS21245	COG2274	protein secretion by the type I secretion system
LDP65_RS21250	COG0438	transferase activity, transferring glycosyl groups
LDP65_RS21260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDP65_RS21275	COG0183	Belongs to the thiolase family
LDP65_RS21280	COG3214	Protein conserved in bacteria
LDP65_RS21285	COG0583	DNA-binding transcription factor activity
LDP65_RS21305	COG0625	glutathione transferase activity
LDP65_RS21315	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LDP65_RS21345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDP65_RS21375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDP65_RS21380	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LDP65_RS21415	COG0024	Methionine aminopeptidase
LDP65_RS21455	COG0058	SHG alpha-glucan phosphorylase activity
LDP65_RS21460	COG1640	4-alpha-glucanotransferase
LDP65_RS21465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LDP65_RS21505	COG3123	guanosine phosphorylase activity
LDP65_RS21515	COG0697	spore germination
LDP65_RS21525	COG5001	Diguanylate cyclase
LDP65_RS21560	COG1054	Belongs to the UPF0176 family
LDP65_RS21590	COG1794	racemase activity, acting on amino acids and derivatives
LDP65_RS21605	COG2329	Antibiotic biosynthesis monooxygenase
LDP65_RS21610	COG0454	-acetyltransferase
LDP65_RS21620	COG0366	Alpha amylase catalytic
LDP65_RS21775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDP65_RS21885	COG3421	Type III restriction
LDP65_RS21890	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LDP65_RS21955	COG3706	GGDEF domain
LDP65_RS21960	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LDP65_RS21965	COG2204	response regulator
LDP65_RS21995	COG0579	oxidoreductase
LDP65_RS22005	COG0531	amino acid
LDP65_RS22010	COG1522	sequence-specific DNA binding
LDP65_RS22015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDP65_RS22040	COG0402	S-adenosylhomocysteine deaminase activity
LDP65_RS22110	COG2267	carboxylic ester hydrolase activity
LDP65_RS22125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDP65_RS22185	COG2186	Transcriptional regulator
LDP65_RS22190	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDP65_RS22195	COG1309	transcriptional regulator
LDP65_RS22215	COG4266	Belongs to the allantoicase family
LDP65_RS22240	COG1902	pentaerythritol trinitrate reductase activity
LDP65_RS22275	COG5380	lipid catabolic process
LDP65_RS22280	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LDP65_RS22295	COG0798	PFAM Bile acid sodium symporter
LDP65_RS22305	COG1846	Transcriptional regulator
LDP65_RS22350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDP65_RS22355	COG2188	Transcriptional regulator
LDP65_RS22370	COG0395	ABC-type sugar transport system, permease component
LDP65_RS22375	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LDP65_RS22380	COG3842	ATPase activity
LDP65_RS22385	COG1741	Belongs to the pirin family
LDP65_RS22395	COG0778	Nitroreductase
LDP65_RS22400	COG4191	Histidine kinase
LDP65_RS22430	COG1629	transport
LDP65_RS22430	COG4774	siderophore transport
LDP65_RS22440	COG1021	2,3-dihydroxybenzoate-AMP ligase
LDP65_RS22445	COG0287	Prephenate dehydrogenase
LDP65_RS22445	COG1605	Chorismate mutase
LDP65_RS22460	COG1021	2,3-dihydroxybenzoate-AMP ligase
LDP65_RS22465	COG1169	isochorismate synthase
LDP65_RS22470	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS22475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDP65_RS22480	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
LDP65_RS22480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDP65_RS22485	COG4592	Periplasmic binding protein
LDP65_RS22490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDP65_RS22495	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDP65_RS22505	COG1120	ATPase activity
LDP65_RS22515	COG4667	esterase of the alpha-beta hydrolase superfamily
LDP65_RS22520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDP65_RS22550	COG4175	Glycine betaine
LDP65_RS22550	COG3448	diguanylate cyclase activity
LDP65_RS22565	COG2175	clavaminate synthase activity
LDP65_RS22570	COG1280	lysine exporter protein (LysE YggA)
LDP65_RS22580	COG0659	secondary active sulfate transmembrane transporter activity
LDP65_RS22585	COG1085	galactose-1-phosphate uridylyltransferase
LDP65_RS22590	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS22610	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS22630	COG4948	Mandelate Racemase Muconate Lactonizing
LDP65_RS22635	COG2186	Transcriptional regulator
LDP65_RS22680	COG5492	domain, Protein
LDP65_RS22710	COG4964	Belongs to the GSP D family
LDP65_RS22760	COG2885	chlorophyll binding
LDP65_RS22770	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LDP65_RS22780	COG0561	phosphatase activity
LDP65_RS22795	COG3119	arylsulfatase activity
LDP65_RS22800	COG3119	arylsulfatase activity
LDP65_RS22805	COG0641	radical SAM
LDP65_RS22830	COG0488	(ABC) transporter
LDP65_RS22850	COG0604	alcohol dehydrogenase
LDP65_RS22850	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS22850	COG3321	synthase
LDP65_RS22885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDP65_RS22890	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS22895	COG1984	allophanate hydrolase subunit 2
LDP65_RS22900	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LDP65_RS22905	COG0439	Biotin carboxylase
LDP65_RS22920	COG4214	carbohydrate transport
LDP65_RS22925	COG1129	ABC transporter
LDP65_RS22930	COG1879	ABC-type sugar transport system periplasmic component
LDP65_RS22935	COG0583	DNA-binding transcription factor activity
LDP65_RS22940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LDP65_RS22945	COG0574	Belongs to the PEP-utilizing enzyme family
LDP65_RS22945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDP65_RS22955	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS22970	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS22980	COG4948	Mandelate Racemase Muconate Lactonizing
LDP65_RS23015	COG1122	ATPase activity
LDP65_RS23020	COG4720	Psort location CytoplasmicMembrane, score
LDP65_RS23035	COG1011	Hydrolase
LDP65_RS23050	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDP65_RS23055	COG4605	iron ion homeostasis
LDP65_RS23060	COG4604	ABC transporter, ATP-binding protein
LDP65_RS23065	COG2375	cellular response to nickel ion
LDP65_RS23080	COG4771	TonB-dependent receptor
LDP65_RS23085	COG4607	ABC-type enterochelin transport system periplasmic component
LDP65_RS23090	COG0110	maltose O-acetyltransferase activity
LDP65_RS23100	COG4681	YaeQ
LDP65_RS23110	COG2204	response regulator
LDP65_RS23115	COG4191	Histidine kinase
LDP65_RS23125	COG2211	Major facilitator Superfamily
LDP65_RS23130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDP65_RS23145	COG0784	Response regulator, receiver
LDP65_RS23145	COG3437	response regulator, receiver
LDP65_RS23150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDP65_RS23155	COG0814	amino acid
LDP65_RS23160	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LDP65_RS23165	COG0513	Belongs to the DEAD box helicase family
LDP65_RS23170	COG2067	long-chain fatty acid transport protein
LDP65_RS23180	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LDP65_RS23190	COG0714	Associated with various cellular activities
LDP65_RS23195	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LDP65_RS23215	COG0366	Alpha amylase catalytic
LDP65_RS23220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDP65_RS23230	COG2116	formate transmembrane transporter activity
LDP65_RS23235	COG1648	precorrin-2 dehydrogenase activity
LDP65_RS23235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDP65_RS23245	COG0789	Transcriptional regulator
LDP65_RS23270	COG1120	ATPase activity
LDP65_RS23275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDP65_RS23280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDP65_RS23285	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LDP65_RS23290	COG3530	Putative quorum-sensing-regulated virulence factor
LDP65_RS23330	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LDP65_RS23335	COG0583	DNA-binding transcription factor activity
LDP65_RS23345	COG4934	collagen metabolic process
LDP65_RS23350	COG0789	Transcriptional regulator
LDP65_RS23365	COG0513	Belongs to the DEAD box helicase family
LDP65_RS23385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LDP65_RS23390	COG1940	carbohydrate kinase activity
LDP65_RS23395	COG1621	beta-fructofuranosidase activity
LDP65_RS23415	COG0572	uridine kinase
LDP65_RS23425	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS23430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDP65_RS23440	COG4589	Belongs to the CDS family
LDP65_RS23450	COG0564	pseudouridine synthase activity
LDP65_RS23480	COG1609	Transcriptional regulator
LDP65_RS23485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LDP65_RS23490	COG3265	gluconokinase activity
LDP65_RS23505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDP65_RS23510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDP65_RS23510	COG4191	Histidine kinase
LDP65_RS23520	COG2354	Protein conserved in bacteria
LDP65_RS23530	COG1879	ABC-type sugar transport system periplasmic component
LDP65_RS23540	COG4214	carbohydrate transport
LDP65_RS23550	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS23555	COG3734	2-keto-3-deoxy-galactonokinase
LDP65_RS23560	COG0800	Aldolase
LDP65_RS23565	COG4948	Mandelate Racemase Muconate Lactonizing
LDP65_RS23610	COG3338	carbonate dehydratase activity
LDP65_RS23625	COG1879	ABC-type sugar transport system periplasmic component
LDP65_RS23630	COG1129	ABC transporter
LDP65_RS23635	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS23640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDP65_RS23645	COG1349	DNA-binding transcription factor activity
LDP65_RS23650	COG5001	Diguanylate cyclase
LDP65_RS23650	COG5002	protein histidine kinase activity
LDP65_RS23650	COG3447	MASE1 domain protein
LDP65_RS23660	COG2814	Major facilitator Superfamily
LDP65_RS23670	COG5002	protein histidine kinase activity
LDP65_RS23690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDP65_RS23700	COG5001	Diguanylate cyclase
LDP65_RS23705	COG2897	thiosulfate sulfurtransferase activity
LDP65_RS23730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LDP65_RS23740	COG0302	gtp cyclohydrolase
LDP65_RS23745	COG0840	transmembrane signaling receptor activity
LDP65_RS23750	COG0545	Peptidyl-prolyl cis-trans isomerase
LDP65_RS23760	COG2885	chlorophyll binding
LDP65_RS23765	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LDP65_RS23770	COG0668	transmembrane transport
LDP65_RS23790	COG1765	OsmC-like protein
LDP65_RS23820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LDP65_RS23825	COG5654	RES domain protein
LDP65_RS23845	COG0745	RESPONSE REGULATOR receiver
LDP65_RS23860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LDP65_RS23875	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LDP65_RS23880	COG0513	Belongs to the DEAD box helicase family
LDP65_RS23885	COG0625	glutathione transferase activity
LDP65_RS23895	COG0840	transmembrane signaling receptor activity
LDP65_RS23915	COG2824	Alkylphosphonate utilization operon protein PhnA
LDP65_RS23920	COG2267	carboxylic ester hydrolase activity
LDP65_RS23925	COG2067	long-chain fatty acid transport protein
LDP65_RS23935	COG2050	protein possibly involved in aromatic compounds catabolism
LDP65_RS23945	COG4533	DNA binding
LDP65_RS23970	COG0747	negative chemotaxis
LDP65_RS23975	COG0444	Belongs to the ABC transporter superfamily
LDP65_RS23980	COG4608	Belongs to the ABC transporter superfamily
LDP65_RS23985	COG0601	transmembrane transport
LDP65_RS23990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDP65_RS24035	COG3118	belongs to the thioredoxin family
LDP65_RS24045	COG4191	Histidine kinase
LDP65_RS24055	COG2271	Major facilitator Superfamily
LDP65_RS24060	COG0469	pyruvate kinase activity
LDP65_RS24065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDP65_RS24070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDP65_RS24090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDP65_RS24095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDP65_RS24100	COG4206	TonB-dependent receptor
LDP65_RS24120	COG0583	DNA-binding transcription factor activity
LDP65_RS24125	COG0045	succinate-CoA ligase (ADP-forming) activity
LDP65_RS24125	COG1042	CoA-binding domain protein
LDP65_RS24125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDP65_RS24135	COG1181	Belongs to the D-alanine--D-alanine ligase family
LDP65_RS24150	COG0023	Translation Initiation Factor
LDP65_RS24160	COG3140	Belongs to the UPF0181 family
LDP65_RS24175	COG0745	RESPONSE REGULATOR receiver
LDP65_RS24185	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LDP65_RS24190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LDP65_RS24215	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LDP65_RS24220	COG4251	negative regulation of phosphorylation
LDP65_RS24220	COG5001	Diguanylate cyclase
LDP65_RS24220	COG2203	Gaf domain
LDP65_RS24220	COG3706	GGDEF domain
LDP65_RS24230	COG2885	chlorophyll binding
LDP65_RS24235	COG0840	transmembrane signaling receptor activity
LDP65_RS24250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LDP65_RS24255	COG4149	molybdate abc transporter
LDP65_RS24260	COG1492	cobalamin metabolic process
LDP65_RS24275	COG0189	ligase activity
LDP65_RS24275	COG4067	protein conserved in archaea
LDP65_RS24285	COG0602	queuosine metabolic process
LDP65_RS24290	COG1328	CTP reductase activity
LDP65_RS24310	COG0584	glycerophosphoryl diester phosphodiesterase
LDP65_RS24320	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LDP65_RS24325	COG3639	organic phosphonate transmembrane transporter activity
LDP65_RS24330	COG3639	organic phosphonate transmembrane transporter activity
LDP65_RS24335	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LDP65_RS24340	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LDP65_RS24345	COG4181	ATPase activity
LDP65_RS24355	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LDP65_RS24360	COG5001	Diguanylate cyclase
LDP65_RS24360	COG1716	ATPase activity
LDP65_RS24370	COG0737	Belongs to the 5'-nucleotidase family
LDP65_RS24375	COG3593	DNA synthesis involved in DNA repair
LDP65_RS24385	COG0583	DNA-binding transcription factor activity
LDP65_RS24390	COG2116	formate transmembrane transporter activity
LDP65_RS24395	COG2353	YceI-like domain
LDP65_RS24400	COG3038	cytochrome b561
LDP65_RS24410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LDP65_RS24430	COG2200	EAL domain
LDP65_RS24450	COG1129	ABC transporter
LDP65_RS24455	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS24460	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS24465	COG1879	ABC-type sugar transport system periplasmic component
LDP65_RS24475	COG0459	protein refolding
LDP65_RS24480	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDP65_RS24485	COG1012	belongs to the aldehyde dehydrogenase family
LDP65_RS24490	COG0022	dehydrogenase e1 component
LDP65_RS24495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LDP65_RS24505	COG1609	Transcriptional regulator
LDP65_RS24515	COG2200	EAL domain
LDP65_RS24515	COG2199	diguanylate cyclase activity
LDP65_RS24515	COG2203	Gaf domain
LDP65_RS24520	COG0523	cobalamin synthesis protein
LDP65_RS24530	COG0156	8-amino-7-oxononanoate synthase activity
LDP65_RS24535	COG0784	Response regulator, receiver
LDP65_RS24535	COG2205	protein histidine kinase activity
LDP65_RS24540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LDP65_RS24545	COG5001	Diguanylate cyclase
LDP65_RS24545	COG3300	MHYT domain
LDP65_RS24560	COG2154	pterin-4-alpha-carbinolamine dehydratase
LDP65_RS24565	COG0456	acetyltransferase
LDP65_RS24570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDP65_RS24575	COG0662	Cupin 2, conserved barrel domain protein
LDP65_RS24580	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LDP65_RS24620	COG0516	GMP reductase activity
LDP65_RS24625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDP65_RS24645	COG2199	diguanylate cyclase activity
LDP65_RS24665	COG2205	protein histidine kinase activity
LDP65_RS24665	COG2198	Histidine kinase
LDP65_RS24665	COG0784	Response regulator, receiver
LDP65_RS24670	COG1879	ABC-type sugar transport system periplasmic component
LDP65_RS24675	COG1803	Methylglyoxal synthase
LDP65_RS24695	COG0210	DNA helicase
LDP65_RS24700	COG1289	transmembrane transporter activity
LDP65_RS24715	COG0861	Integral membrane protein TerC family
LDP65_RS24730	COG1028	Short-chain dehydrogenase reductase Sdr
LDP65_RS24750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LDP65_RS24755	COG1063	alcohol dehydrogenase
LDP65_RS24760	COG0156	8-amino-7-oxononanoate synthase activity
LDP65_RS24775	COG0583	DNA-binding transcription factor activity
LDP65_RS24795	COG5001	Diguanylate cyclase
LDP65_RS24800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LDP65_RS24805	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LDP65_RS24835	COG0406	alpha-ribazole phosphatase activity
LDP65_RS24840	COG4191	Histidine kinase
LDP65_RS24920	COG2197	response regulator
LDP65_RS24925	COG3850	Histidine kinase
LDP65_RS24930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDP65_RS24930	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDP65_RS24970	COG0183	Belongs to the thiolase family
LDP65_RS24985	COG2827	Endonuclease containing a URI domain
LDP65_RS24990	COG3132	Protein of unknown function, DUF480
LDP65_RS24995	COG2926	Belongs to the UPF0265 family
LDP65_RS25010	COG0584	glycerophosphoryl diester phosphodiesterase
LDP65_RS25040	COG0784	Response regulator, receiver
LDP65_RS25040	COG2205	protein histidine kinase activity
LDP65_RS25050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDP65_RS25060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS25065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDP65_RS25070	COG0784	Response regulator, receiver
LDP65_RS25070	COG0835	chemotaxis
LDP65_RS25075	COG1454	alcohol dehydrogenase
LDP65_RS25115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LDP65_RS25125	COG0633	Ferredoxin
LDP65_RS25125	COG3217	Mosc domain protein beta barrel domain protein
LDP65_RS25125	COG0633	Ferredoxin
LDP65_RS25125	COG3217	Mosc domain protein beta barrel domain protein
LDP65_RS25130	COG0418	dihydroorotase activity
LDP65_RS25140	COG1122	ATPase activity
LDP65_RS25145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LDP65_RS25150	COG1268	BioY protein
LDP65_RS25165	COG3706	GGDEF domain
LDP65_RS25205	COG0840	transmembrane signaling receptor activity
LDP65_RS25225	COG1609	Transcriptional regulator
LDP65_RS25235	COG1105	Belongs to the carbohydrate kinase PfkB family
LDP65_RS25240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LDP65_RS25240	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LDP65_RS25240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LDP65_RS25245	COG3479	Phenolic acid decarboxylase
LDP65_RS25260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDP65_RS25270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDP65_RS25275	COG0509	glycine decarboxylation via glycine cleavage system
LDP65_RS25345	COG1917	Cupin 2, conserved barrel domain protein
LDP65_RS25345	COG4977	sequence-specific DNA binding
LDP65_RS25375	COG4771	TonB-dependent receptor
LDP65_RS25380	COG2382	esterase
LDP65_RS25385	COG2130	NADP-dependent
LDP65_RS25415	COG1620	l-lactate permease
LDP65_RS25420	COG1304	FMN binding
LDP65_RS25445	COG1247	-acetyltransferase
LDP65_RS25450	COG0494	nUDIX hydrolase
LDP65_RS25480	COG2818	Glycosylase
LDP65_RS25495	COG0456	acetyltransferase
LDP65_RS25500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LDP65_RS25515	COG1653	transport
LDP65_RS25525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDP65_RS25530	COG3279	Response regulator of the LytR AlgR family
LDP65_RS25535	COG3275	phosphorelay sensor kinase activity
LDP65_RS25555	COG1136	(ABC) transporter
LDP65_RS25555	COG0577	efflux transmembrane transporter activity
LDP65_RS25580	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LDP65_RS25590	COG2755	lipolytic protein G-D-S-L family
LDP65_RS25590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LDP65_RS25630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LDP65_RS25630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LDP65_RS25640	COG2814	Major facilitator Superfamily
LDP65_RS25650	COG0673	inositol 2-dehydrogenase activity
LDP65_RS25655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDP65_RS25675	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LDP65_RS25695	COG4166	transmembrane transport
LDP65_RS25700	COG4174	ABC transporter (Permease)
LDP65_RS25705	COG4239	(ABC) transporter, permease
LDP65_RS25710	COG4172	Belongs to the ABC transporter superfamily
LDP65_RS25720	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LDP65_RS25730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LDP65_RS25735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LDP65_RS25740	COG1609	Transcriptional regulator
LDP65_RS25820	COG2017	converts alpha-aldose to the beta-anomer
LDP65_RS25825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LDP65_RS25830	COG1085	galactose-1-phosphate uridylyltransferase
LDP65_RS25835	COG3250	beta-galactosidase activity
LDP65_RS25845	COG0395	ABC-type sugar transport system, permease component
LDP65_RS25850	COG1175	transmembrane transport
LDP65_RS25945	COG0346	lactoylglutathione lyase activity
LDP65_RS25955	COG0346	lactoylglutathione lyase activity
LDP65_RS25970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LDP65_RS25975	COG3842	ATPase activity
LDP65_RS25995	COG1609	Transcriptional regulator
LDP65_RS26010	COG0747	negative chemotaxis
LDP65_RS26020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDP65_RS26025	COG0444	Belongs to the ABC transporter superfamily
LDP65_RS26030	COG4608	Belongs to the ABC transporter superfamily
LDP65_RS26055	COG1247	-acetyltransferase
LDP65_RS26060	COG0730	response to heat
LDP65_RS26315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LDP65_RS26340	COG0527	aspartate kinase activity
LDP65_RS26355	COG3706	GGDEF domain
LDP65_RS26365	COG0840	transmembrane signaling receptor activity
LDP65_RS26695	COG0582	viral genome integration into host DNA
LDP65_RS26865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LDP65_RS26900	COG3706	GGDEF domain
LDP65_RS27235	COG5377	YqaJ viral recombinase family
LDP65_RS27260	COG0582	viral genome integration into host DNA
LDP65_RS27295	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDP65_RS27330	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LDP65_RS27335	COG0753	catalase activity
LDP65_RS27345	COG3300	MHYT domain
LDP65_RS27345	COG5001	Diguanylate cyclase
LDP65_RS27350	COG1802	Transcriptional regulator
LDP65_RS27355	COG4608	Belongs to the ABC transporter superfamily
LDP65_RS27360	COG0444	Belongs to the ABC transporter superfamily
LDP65_RS27365	COG0601	transmembrane transport
LDP65_RS27370	COG0747	negative chemotaxis
LDP65_RS27425	COG3046	protein related to deoxyribodipyrimidine photolyase
LDP65_RS27450	COG4628	conserved protein (DUF2132)
LDP65_RS27465	COG0251	oxidation-reduction process
LDP65_RS27475	COG0069	glutamate synthase activity
LDP65_RS27510	COG0456	acetyltransferase
LDP65_RS27520	COG1653	transport
LDP65_RS27540	COG3842	ATPase activity
LDP65_RS27555	COG0363	glucosamine-6-phosphate deaminase activity
LDP65_RS27565	COG0513	Belongs to the DEAD box helicase family
LDP65_RS27580	COG1349	DNA-binding transcription factor activity
LDP65_RS27585	COG1349	DNA-binding transcription factor activity
LDP65_RS27595	COG2222	sugar isomerase
LDP65_RS27600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDP65_RS27610	COG3716	PTS system mannose fructose sorbose family IID component
LDP65_RS27615	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDP65_RS27645	COG0588	phosphoglycerate mutase activity
LDP65_RS27650	COG0640	Transcriptional regulator
LDP65_RS27670	COG0583	DNA-binding transcription factor activity
LDP65_RS27675	COG2124	cytochrome p450
LDP65_RS27685	COG2226	methyltransferase
LDP65_RS27695	COG2501	S4 domain
LDP65_RS27705	COG1280	lysine exporter protein (LysE YggA)
LDP65_RS27730	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LDP65_RS27755	COG1132	(ABC) transporter
LDP65_RS27775	COG1522	sequence-specific DNA binding
LDP65_RS27780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LDP65_RS27795	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LDP65_RS27800	COG3036	rescue of stalled ribosome
LDP65_RS27830	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDP65_RS27835	COG1846	Transcriptional regulator
LDP65_RS27840	COG0419	ATPase involved in DNA repair
LDP65_RS27845	COG0420	3'-5' exonuclease activity
LDP65_RS27860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDP65_RS27900	COG0438	transferase activity, transferring glycosyl groups
LDP65_RS27910	COG5039	Polysaccharide pyruvyl transferase
LDP65_RS27915	COG1216	Glycosyl transferase, family 2
LDP65_RS27915	COG0463	Glycosyl transferase, family 2
LDP65_RS27935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDP65_RS27940	COG2197	response regulator
LDP65_RS27955	COG3833	ABC-type maltose transport systems, permease component
LDP65_RS27960	COG1175	transmembrane transport
LDP65_RS27970	COG3842	ATPase activity
LDP65_RS27990	COG0840	transmembrane signaling receptor activity
LDP65_RS27995	COG0714	Associated with various cellular activities
LDP65_RS28015	COG2304	oxidoreductase activity
LDP65_RS28025	COG3850	Histidine kinase
LDP65_RS28025	COG5002	protein histidine kinase activity
LDP65_RS28030	COG0745	RESPONSE REGULATOR receiver
LDP65_RS28035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDP65_RS28035	COG4191	Histidine kinase
LDP65_RS28040	COG0784	Response regulator, receiver
LDP65_RS28040	COG3437	response regulator, receiver
LDP65_RS28050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDP65_RS28060	COG0109	protoheme IX farnesyltransferase activity
LDP65_RS28065	COG1612	heme a metabolic process
LDP65_RS28090	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LDP65_RS28095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDP65_RS28100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LDP65_RS28105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDP65_RS28115	COG0560	Phosphoserine phosphatase
LDP65_RS28120	COG2197	response regulator
LDP65_RS28130	COG0318	PFAM AMP-dependent synthetase and ligase
LDP65_RS28150	COG2205	protein histidine kinase activity
LDP65_RS28150	COG2202	Pas domain
LDP65_RS28155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDP65_RS28160	COG1283	sodium-dependent phosphate transmembrane transporter activity
LDP65_RS28165	COG1126	abc transporter atp-binding protein
LDP65_RS28170	COG0765	amino acid transport
LDP65_RS28175	COG4597	amino acid ABC transporter
LDP65_RS28180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDP65_RS28195	COG3842	ATPase activity
LDP65_RS28210	COG1176	ABC-type spermidine putrescine transport system, permease component I
LDP65_RS28275	COG4172	Belongs to the ABC transporter superfamily
LDP65_RS28295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDP65_RS28320	COG0346	lactoylglutathione lyase activity
LDP65_RS28325	COG4326	sporulation control protein
LDP65_RS28355	COG0456	acetyltransferase
LDP65_RS28395	COG0583	DNA-binding transcription factor activity
LDP65_RS28400	COG2814	Major facilitator Superfamily
LDP65_RS28420	COG1175	transmembrane transport
LDP65_RS28430	COG1609	Transcriptional regulator
LDP65_RS28440	COG1335	isochorismatase
LDP65_RS28445	COG2249	NAD(P)H dehydrogenase (quinone) activity
LDP65_RS28455	COG1917	Cupin 2, conserved barrel domain protein
LDP65_RS28455	COG4977	sequence-specific DNA binding
LDP65_RS28465	COG0583	DNA-binding transcription factor activity
LDP65_RS28480	COG0583	DNA-binding transcription factor activity
LDP65_RS28485	COG1414	Transcriptional regulator
LDP65_RS28495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDP65_RS28500	COG0601	transmembrane transport
LDP65_RS28510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LDP65_RS28530	COG0515	serine threonine protein kinase
LDP65_RS28530	COG2815	serine threonine protein kinase
LDP65_RS28575	COG1181	Belongs to the D-alanine--D-alanine ligase family
LDP65_RS28650	COG3284	Transcriptional regulator
LDP65_RS28655	COG3842	ATPase activity
LDP65_RS28660	COG3842	ATPase activity
LDP65_RS28670	COG0395	ABC-type sugar transport system, permease component
LDP65_RS28705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDP65_RS28770	COG1940	carbohydrate kinase activity
LDP65_RS28780	COG3842	ATPase activity
LDP65_RS28795	COG0076	glutamate decarboxylase activity
LDP65_RS28805	COG4191	Histidine kinase
LDP65_RS28805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDP65_RS28815	COG0784	Response regulator, receiver
LDP65_RS28815	COG3437	response regulator, receiver
LDP65_RS28840	COG1770	oligopeptidase
LDP65_RS28855	COG0395	ABC-type sugar transport system, permease component
LDP65_RS28860	COG2723	6-phospho-beta-galactosidase activity
LDP65_RS28865	COG3842	ATPase activity
LDP65_RS28870	COG1609	Transcriptional regulator
LDP65_RS28885	COG0513	Belongs to the DEAD box helicase family
LDP65_RS28895	COG1376	ErfK ybiS ycfS ynhG family protein
LDP65_RS28895	COG1388	LysM domain
LDP65_RS28900	COG0415	Belongs to the DNA photolyase family
LDP65_RS28905	COG0789	Transcriptional regulator
LDP65_RS28910	COG3272	Protein of unknown function (DUF1722)
LDP65_RS28925	COG4214	carbohydrate transport
LDP65_RS28940	COG1609	Transcriptional regulator
LDP65_RS28945	COG0813	purine-nucleoside phosphorylase activity
LDP65_RS28975	COG1566	PFAM secretion protein HlyD family protein
LDP65_RS28985	COG3706	GGDEF domain
LDP65_RS28990	COG0693	protein deglycase activity
LDP65_RS29005	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LDP65_RS29015	COG1505	serine-type exopeptidase activity
LDP65_RS29035	COG3314	Sporulation integral membrane protein YlbJ
LDP65_RS29070	COG1595	DNA-templated transcription, initiation
LDP65_RS29080	COG1505	serine-type exopeptidase activity
LDP65_RS29085	COG1737	Transcriptional regulator
LDP65_RS29095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDP65_RS29105	COG2140	Oxalate decarboxylase
LDP65_RS29110	COG1175	transmembrane transport
LDP65_RS29115	COG0395	ABC-type sugar transport system, permease component
LDP65_RS29125	COG3842	ATPase activity
LDP65_RS29135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDP65_RS29145	COG1349	DNA-binding transcription factor activity
LDP65_RS29150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDP65_RS29215	COG1917	Cupin 2, conserved barrel domain protein
LDP65_RS29215	COG2207	Transcriptional regulator
LDP65_RS29225	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LDP65_RS29230	COG0363	glucosamine-6-phosphate deaminase activity
LDP65_RS29235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LDP65_RS29250	COG1278	Cold shock
LDP65_RS29260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDP65_RS29265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDP65_RS29265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LDP65_RS29280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LDP65_RS29330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDP65_RS29335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDP65_RS29350	COG4336	lyase activity
LDP65_RS29355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS29375	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LDP65_RS29380	COG1984	allophanate hydrolase subunit 2
LDP65_RS29410	COG0840	transmembrane signaling receptor activity
LDP65_RS29415	COG0786	glutamate:sodium symporter activity
LDP65_RS29420	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LDP65_RS29425	COG0583	DNA-binding transcription factor activity
LDP65_RS29430	COG0583	DNA-binding transcription factor activity
LDP65_RS29435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDP65_RS29445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDP65_RS29450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDP65_RS29510	COG0456	acetyltransferase
LDP65_RS29535	COG2135	peptidase activity
LDP65_RS29540	COG3070	regulator of competence-specific genes
LDP65_RS29550	COG2175	clavaminate synthase activity
LDP65_RS29560	COG1228	amidohydrolase
LDP65_RS29565	COG0840	transmembrane signaling receptor activity
LDP65_RS29575	COG2146	nitrite reductase [NAD(P)H] activity
LDP65_RS29575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDP65_RS29580	COG1116	anion transmembrane transporter activity
LDP65_RS29585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDP65_RS29600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDP65_RS29610	COG0243	molybdopterin cofactor binding
LDP65_RS29625	COG1280	lysine exporter protein (LysE YggA)
LDP65_RS29640	COG0463	Glycosyl transferase, family 2
LDP65_RS29640	COG1216	Glycosyl transferase, family 2
LDP65_RS29665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LDP65_RS29670	COG3852	Histidine kinase
LDP65_RS29675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LDP65_RS29685	COG1609	Transcriptional regulator
LDP65_RS29690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDP65_RS29695	COG1879	ABC-type sugar transport system periplasmic component
LDP65_RS29700	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDP65_RS29705	COG1129	ABC transporter
LDP65_RS29710	COG1869	D-ribose catabolic process
LDP65_RS29715	COG0583	DNA-binding transcription factor activity
LDP65_RS29720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LDP65_RS29730	COG1280	lysine exporter protein (LysE YggA)
LDP65_RS29750	COG2084	Dehydrogenase
LDP65_RS29790	COG0753	catalase activity
LDP65_RS29805	COG0583	DNA-binding transcription factor activity
LDP65_RS29810	COG0668	transmembrane transport
LDP65_RS29815	COG1418	mRNA catabolic process
LDP65_RS29860	COG2755	lipolytic protein G-D-S-L family
LDP65_RS29890	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LDP65_RS29910	COG0583	DNA-binding transcription factor activity
LDP65_RS29920	COG0625	glutathione transferase activity
LDP65_RS29935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LDP65_RS29940	COG0070	glutamate synthase
LDP65_RS29940	COG0069	glutamate synthase activity
LDP65_RS29940	COG0067	glutamate synthase
LDP65_RS29955	COG3706	GGDEF domain
LDP65_RS29965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDP65_RS29975	COG0506	proline dehydrogenase activity
LDP65_RS29975	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LDP65_RS29975	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LDP65_RS29990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LDP65_RS29995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDP65_RS30000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDP65_RS30005	COG1121	(ABC) transporter
LDP65_RS30025	COG0259	pyridoxamine-phosphate oxidase activity
LDP65_RS30045	COG2274	protein secretion by the type I secretion system
LDP65_RS30050	COG1063	alcohol dehydrogenase
LDP65_RS30060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LDP65_RS30105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LDP65_RS30110	COG0840	transmembrane signaling receptor activity
LDP65_RS30120	COG0835	chemotaxis
LDP65_RS30135	COG0745	RESPONSE REGULATOR receiver
LDP65_RS30145	COG1444	tRNA N-acetyltransferase activity
LDP65_RS30230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDP65_RS30245	COG0681	Belongs to the peptidase S26 family
LDP65_RS30295	COG0714	Associated with various cellular activities
LDP65_RS30380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDP65_RS30480	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LDP65_RS30650	COG3423	Transcriptional regulator
LDP65_RS30790	COG3209	COG3209 Rhs family protein
LDP65_RS30800	COG3209	COG3209 Rhs family protein
LDP65_RS30910	COG1192	Involved in chromosome partitioning
LDP65_RS31035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LDP65_RS31125	COG5377	YqaJ viral recombinase family