locus-tag	class	description
VRUMOI_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VRUMOI_RS00015	COG0706	membrane insertase activity
VRUMOI_RS00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VRUMOI_RS00030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VRUMOI_RS00035	COG1126	abc transporter atp-binding protein
VRUMOI_RS00045	COG4178	(ABC) transporter
VRUMOI_RS00060	COG0592	DNA-directed DNA polymerase activity
VRUMOI_RS00065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VRUMOI_RS00070	COG0187	DNA topoisomerase II activity
VRUMOI_RS00080	COG0071	Belongs to the small heat shock protein (HSP20) family
VRUMOI_RS00085	COG3977	Valine--pyruvate aminotransferase
VRUMOI_RS00095	COG0751	glycine-tRNA ligase activity
VRUMOI_RS00100	COG0752	glycyl-tRNA synthetase alpha subunit
VRUMOI_RS00105	COG1971	Probably functions as a manganese efflux pump
VRUMOI_RS00115	COG0425	Belongs to the sulfur carrier protein TusA family
VRUMOI_RS00130	COG0019	diaminopimelate decarboxylase activity
VRUMOI_RS00135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VRUMOI_RS00145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VRUMOI_RS00150	COG1011	Hydrolase
VRUMOI_RS00155	COG3148	PFAM DTW domain containing protein
VRUMOI_RS00170	COG0561	phosphatase activity
VRUMOI_RS00175	COG2267	carboxylic ester hydrolase activity
VRUMOI_RS00180	COG0640	Transcriptional regulator
VRUMOI_RS00185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VRUMOI_RS00220	COG2095	MarC family integral membrane protein
VRUMOI_RS00230	COG0742	ribosomal rna small subunit methyltransferase
VRUMOI_RS00235	COG0552	protein localization to endoplasmic reticulum
VRUMOI_RS00240	COG2884	Cell division ATP-binding protein ftsE
VRUMOI_RS00245	COG2177	Part of the ABC transporter FtsEX involved in
VRUMOI_RS00255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VRUMOI_RS00260	COG0705	Rhomboid family
VRUMOI_RS00265	COG3161	chorismate lyase activity
VRUMOI_RS00270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VRUMOI_RS00275	COG3071	HemY protein
VRUMOI_RS00280	COG2959	enzyme of heme biosynthesis
VRUMOI_RS00285	COG1587	Uroporphyrinogen-III synthase
VRUMOI_RS00300	COG0183	Belongs to the thiolase family
VRUMOI_RS00305	COG1250	3-hydroxyacyl-CoA dehydrogenase
VRUMOI_RS00305	COG1024	Enoyl-CoA hydratase
VRUMOI_RS00310	COG1739	Uncharacterized protein family UPF0029
VRUMOI_RS00320	COG3335	DDE superfamily endonuclease
VRUMOI_RS00370	COG2937	Belongs to the GPAT DAPAT family
VRUMOI_RS00375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VRUMOI_RS00380	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VRUMOI_RS00385	COG0534	Mate efflux family protein
VRUMOI_RS00390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VRUMOI_RS00400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VRUMOI_RS00405	COG4206	TonB-dependent receptor
VRUMOI_RS00410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VRUMOI_RS00450	COG0038	chloride channel
VRUMOI_RS00465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VRUMOI_RS00470	COG2104	thiamine diphosphate biosynthetic process
VRUMOI_RS00475	COG2022	thiamine diphosphate biosynthetic process
VRUMOI_RS00485	COG0006	proline dipeptidase activity
VRUMOI_RS00500	COG1322	Protein conserved in bacteria
VRUMOI_RS00505	COG2226	methyltransferase
VRUMOI_RS00515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VRUMOI_RS00520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VRUMOI_RS00525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VRUMOI_RS00530	COG0805	protein transport
VRUMOI_RS00535	COG0084	hydrolase, TatD family'
VRUMOI_RS00545	COG0248	Ppx GppA phosphatase
VRUMOI_RS00550	COG0513	Belongs to the DEAD box helicase family
VRUMOI_RS00555	COG3118	belongs to the thioredoxin family
VRUMOI_RS00570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VRUMOI_RS00575	COG0633	Ferredoxin
VRUMOI_RS00620	COG0583	DNA-binding transcription factor activity
VRUMOI_RS00625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VRUMOI_RS00630	COG2960	long-chain fatty acid transporting porin activity
VRUMOI_RS00635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VRUMOI_RS00640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VRUMOI_RS00645	COG1309	transcriptional regulator
VRUMOI_RS00650	COG0210	DNA helicase
VRUMOI_RS00695	COG0601	transmembrane transport
VRUMOI_RS00700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VRUMOI_RS00705	COG0673	inositol 2-dehydrogenase activity
VRUMOI_RS00725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VRUMOI_RS00730	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VRUMOI_RS00740	COG2207	Transcriptional regulator
VRUMOI_RS00740	COG3708	Transcriptional regulator
VRUMOI_RS00745	COG0583	DNA-binding transcription factor activity
VRUMOI_RS00760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VRUMOI_RS00775	COG1522	sequence-specific DNA binding
VRUMOI_RS00780	COG5002	protein histidine kinase activity
VRUMOI_RS00780	COG5001	Diguanylate cyclase
VRUMOI_RS00790	COG4067	protein conserved in archaea
VRUMOI_RS00790	COG0189	ligase activity
VRUMOI_RS00830	COG0589	response to stress
VRUMOI_RS00835	COG1528	Iron-storage protein
VRUMOI_RS00845	COG2081	HI0933 family
VRUMOI_RS00870	COG0464	growth
VRUMOI_RS00875	COG1404	Belongs to the peptidase S8 family
VRUMOI_RS00880	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
VRUMOI_RS00885	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VRUMOI_RS00930	COG3604	Transcriptional regulator
VRUMOI_RS00935	COG0783	Belongs to the Dps family
VRUMOI_RS00940	COG0471	metal ion transport
VRUMOI_RS00985	COG0210	DNA helicase
VRUMOI_RS00990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VRUMOI_RS00995	COG0205	6-phosphofructokinase activity
VRUMOI_RS01015	COG0534	Mate efflux family protein
VRUMOI_RS01030	COG1494	fructose-1,6-bisphosphatase
VRUMOI_RS01035	COG3074	FtsZ-dependent cytokinesis
VRUMOI_RS01040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VRUMOI_RS01045	COG1575	Belongs to the MenA family. Type 1 subfamily
VRUMOI_RS01050	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VRUMOI_RS01055	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VRUMOI_RS01060	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VRUMOI_RS01065	COG1609	Transcriptional regulator
VRUMOI_RS01070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VRUMOI_RS01075	COG0254	rRNA binding
VRUMOI_RS01080	COG0281	malic enzyme
VRUMOI_RS01085	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VRUMOI_RS01090	COG0626	cystathionine gamma-synthase activity
VRUMOI_RS01095	COG0527	aspartate kinase activity
VRUMOI_RS01095	COG0460	homoserine dehydrogenase
VRUMOI_RS01100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VRUMOI_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VRUMOI_RS01115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VRUMOI_RS01120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VRUMOI_RS01130	COG0137	argininosuccinate synthase activity
VRUMOI_RS01135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VRUMOI_RS01135	COG0165	Argininosuccinate lyase
VRUMOI_RS01145	COG1566	PFAM secretion protein HlyD family protein
VRUMOI_RS01160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VRUMOI_RS01190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VRUMOI_RS01205	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VRUMOI_RS01210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VRUMOI_RS01215	COG0546	phosphoglycolate phosphatase activity
VRUMOI_RS01220	COG0180	Tryptophanyl-tRNA synthetase
VRUMOI_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
VRUMOI_RS01230	COG1960	acyl-CoA dehydrogenase activity
VRUMOI_RS01235	COG0512	Glutamine amidotransferase of anthranilate synthase
VRUMOI_RS01255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VRUMOI_RS01265	COG0194	GDP metabolic process
VRUMOI_RS01280	COG3118	belongs to the thioredoxin family
VRUMOI_RS01285	COG4232	protein-disulfide reductase activity
VRUMOI_RS01295	COG1561	YicC-like family, N-terminal region
VRUMOI_RS01300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VRUMOI_RS01305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VRUMOI_RS01310	COG0814	amino acid
VRUMOI_RS01320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VRUMOI_RS01325	COG3954	Phosphoribulokinase
VRUMOI_RS01330	COG3089	Belongs to the UPF0270 family
VRUMOI_RS01340	COG0488	(ABC) transporter
VRUMOI_RS01345	COG2249	NAD(P)H dehydrogenase (quinone) activity
VRUMOI_RS01355	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VRUMOI_RS01360	COG1047	Peptidyl-prolyl cis-trans
VRUMOI_RS01365	COG2900	Belongs to the SlyX family
VRUMOI_RS01370	COG0545	Peptidyl-prolyl cis-trans isomerase
VRUMOI_RS01375	COG2964	Protein conserved in bacteria
VRUMOI_RS01380	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VRUMOI_RS01385	COG2923	Belongs to the DsrF TusC family
VRUMOI_RS01405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VRUMOI_RS01410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VRUMOI_RS01415	COG0051	transcription antitermination factor activity, RNA binding
VRUMOI_RS01420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VRUMOI_RS01425	COG0088	Forms part of the polypeptide exit tunnel
VRUMOI_RS01430	COG0089	rRNA binding
VRUMOI_RS01435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VRUMOI_RS01440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VRUMOI_RS01445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VRUMOI_RS01450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VRUMOI_RS01455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VRUMOI_RS01475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VRUMOI_RS01480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VRUMOI_RS01485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VRUMOI_RS01490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VRUMOI_RS01495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VRUMOI_RS01510	COG1841	ribosomal large subunit assembly
VRUMOI_RS01515	COG0200	Binds to the 23S rRNA
VRUMOI_RS01520	COG0201	protein transport
VRUMOI_RS01525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VRUMOI_RS01530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VRUMOI_RS01540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VRUMOI_RS01545	COG0202	RNA polymerase activity
VRUMOI_RS01550	COG0203	ribosomal protein L17
VRUMOI_RS01560	COG0545	Peptidyl-prolyl cis-trans isomerase
VRUMOI_RS01565	COG3266	domain, Protein
VRUMOI_RS01565	COG3061	Opacity-associated protein A
VRUMOI_RS01570	COG2153	protein acetylation
VRUMOI_RS01575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VRUMOI_RS01575	COG1648	precorrin-2 dehydrogenase activity
VRUMOI_RS01585	COG2895	sulfate adenylyltransferase (ATP) activity
VRUMOI_RS01590	COG3273	potassium ion transport
VRUMOI_RS01590	COG0471	metal ion transport
VRUMOI_RS01595	COG0529	Catalyzes the synthesis of activated sulfate
VRUMOI_RS01610	COG1136	(ABC) transporter
VRUMOI_RS01620	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VRUMOI_RS01630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VRUMOI_RS01635	COG0729	surface antigen
VRUMOI_RS01645	COG2105	PFAM AIG2 family protein
VRUMOI_RS01655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VRUMOI_RS01660	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VRUMOI_RS01665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VRUMOI_RS01670	COG0163	prenyltransferase activity
VRUMOI_RS01675	COG4143	(ABC) transporter
VRUMOI_RS01680	COG1178	ABC-type Fe3 transport system permease component
VRUMOI_RS01685	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VRUMOI_RS01695	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VRUMOI_RS01705	COG0564	pseudouridine synthase activity
VRUMOI_RS01710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VRUMOI_RS01715	COG2358	TRAP transporter, solute receptor (TAXI family
VRUMOI_RS01720	COG1438	arginine binding
VRUMOI_RS01725	COG0039	L-malate dehydrogenase activity
VRUMOI_RS01730	COG0142	geranyltranstransferase activity
VRUMOI_RS01740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VRUMOI_RS01745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VRUMOI_RS01750	COG2966	Psort location CytoplasmicMembrane, score
VRUMOI_RS01755	COG3610	response to peptide
VRUMOI_RS01765	COG1289	transmembrane transporter activity
VRUMOI_RS01770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VRUMOI_RS01785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VRUMOI_RS01790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VRUMOI_RS01795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VRUMOI_RS01800	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VRUMOI_RS01810	COG0066	3-isopropylmalate dehydratase activity
VRUMOI_RS01815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VRUMOI_RS01820	COG0473	3-isopropylmalate dehydrogenase activity
VRUMOI_RS01840	COG0583	DNA-binding transcription factor activity
VRUMOI_RS01845	COG0028	Belongs to the TPP enzyme family
VRUMOI_RS01850	COG0440	acetolactate synthase activity
VRUMOI_RS01865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VRUMOI_RS01920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VRUMOI_RS01930	COG3335	DDE superfamily endonuclease
VRUMOI_RS01965	COG2814	Major facilitator Superfamily
VRUMOI_RS01970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VRUMOI_RS01980	COG2897	thiosulfate sulfurtransferase activity
VRUMOI_RS02005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VRUMOI_RS02010	COG0246	Mannitol dehydrogenase
VRUMOI_RS02015	COG0246	Mannitol dehydrogenase
VRUMOI_RS02020	COG0246	Mannitol dehydrogenase
VRUMOI_RS02025	COG1312	Catalyzes the dehydration of D-mannonate
VRUMOI_RS02185	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VRUMOI_RS02205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VRUMOI_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
VRUMOI_RS02215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VRUMOI_RS02255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VRUMOI_RS02260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VRUMOI_RS02270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VRUMOI_RS02275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VRUMOI_RS02300	COG1566	PFAM secretion protein HlyD family protein
VRUMOI_RS02320	COG1584	GPR1 FUN34 yaaH family protein
VRUMOI_RS02325	COG1879	ABC-type sugar transport system periplasmic component
VRUMOI_RS02330	COG1172	Belongs to the binding-protein-dependent transport system permease family
VRUMOI_RS02340	COG0673	inositol 2-dehydrogenase activity
VRUMOI_RS02350	COG1609	Transcriptional regulator
VRUMOI_RS02355	COG4213	ABC transporter substrate-binding protein
VRUMOI_RS02360	COG1129	ABC transporter
VRUMOI_RS02365	COG4214	carbohydrate transport
VRUMOI_RS02370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VRUMOI_RS02375	COG3706	GGDEF domain
VRUMOI_RS02395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VRUMOI_RS02405	COG1610	YqeY-like protein
VRUMOI_RS02410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VRUMOI_RS02415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VRUMOI_RS02420	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VRUMOI_RS02425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VRUMOI_RS02430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VRUMOI_RS02435	COG1968	undecaprenyl-diphosphatase activity
VRUMOI_RS02440	COG0617	tRNA 3'-terminal CCA addition
VRUMOI_RS02445	COG3409	Peptidoglycan-binding domain 1 protein
VRUMOI_RS02445	COG3267	Type II secretory pathway component ExeA
VRUMOI_RS02460	COG4991	sh3 domain protein
VRUMOI_RS02465	COG0306	phosphate transporter
VRUMOI_RS02470	COG1392	Phosphate transport regulator
VRUMOI_RS02475	COG3025	triphosphatase activity
VRUMOI_RS02480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VRUMOI_RS02485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VRUMOI_RS02490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VRUMOI_RS02490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VRUMOI_RS02500	COG3547	Transposase (IS116 IS110 IS902 family)
VRUMOI_RS02510	COG1538	Outer membrane efflux protein
VRUMOI_RS02515	COG0494	nUDIX hydrolase
VRUMOI_RS02520	COG3151	Protein conserved in bacteria
VRUMOI_RS02530	COG3150	esterase
VRUMOI_RS02535	COG0187	DNA topoisomerase II activity
VRUMOI_RS02540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VRUMOI_RS02550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VRUMOI_RS02555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VRUMOI_RS02560	COG3105	Protein conserved in bacteria
VRUMOI_RS02565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VRUMOI_RS02575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VRUMOI_RS02580	COG0723	plastoquinol--plastocyanin reductase activity
VRUMOI_RS02585	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VRUMOI_RS02590	COG2857	Cytochrome c1
VRUMOI_RS02595	COG0625	glutathione transferase activity
VRUMOI_RS02600	COG2969	positive regulation of protein catabolic process
VRUMOI_RS02615	COG0646	methionine synthase
VRUMOI_RS02615	COG1410	methionine synthase
VRUMOI_RS02620	COG0527	aspartate kinase activity
VRUMOI_RS02625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VRUMOI_RS02635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VRUMOI_RS02650	COG0629	single-stranded DNA binding
VRUMOI_RS02655	COG2200	EAL domain
VRUMOI_RS02655	COG2199	diguanylate cyclase activity
VRUMOI_RS02665	COG3335	DDE superfamily endonuclease
VRUMOI_RS02700	COG3547	Transposase (IS116 IS110 IS902 family)
VRUMOI_RS02720	COG1077	Cell shape determining protein MreB Mrl
VRUMOI_RS02725	COG1792	Involved in formation and maintenance of cell shape
VRUMOI_RS02730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VRUMOI_RS02735	COG0424	maF-like protein
VRUMOI_RS02750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VRUMOI_RS02755	COG0312	modulator of DNA gyrase
VRUMOI_RS02760	COG3028	Belongs to the UPF0307 family
VRUMOI_RS02765	COG0312	modulator of DNA gyrase
VRUMOI_RS02770	COG2239	Acts as a magnesium transporter
VRUMOI_RS02775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VRUMOI_RS02780	COG1660	Displays ATPase and GTPase activities
VRUMOI_RS02785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VRUMOI_RS02790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VRUMOI_RS02805	COG1137	ATPase activity
VRUMOI_RS02810	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VRUMOI_RS02820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VRUMOI_RS02825	COG0517	IMP dehydrogenase activity
VRUMOI_RS02825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VRUMOI_RS02835	COG1127	ABC transporter
VRUMOI_RS02840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VRUMOI_RS02845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VRUMOI_RS02850	COG2854	intermembrane phospholipid transfer
VRUMOI_RS02855	COG3113	response to antibiotic
VRUMOI_RS02860	COG5007	Belongs to the BolA IbaG family
VRUMOI_RS02865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VRUMOI_RS02870	COG0204	Acyl-transferase
VRUMOI_RS02885	COG1566	PFAM secretion protein HlyD family protein
VRUMOI_RS02890	COG2814	Major facilitator Superfamily
VRUMOI_RS02915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VRUMOI_RS02930	COG0456	acetyltransferase
VRUMOI_RS02940	COG0525	valine-tRNA ligase activity
VRUMOI_RS02945	COG2927	DNA polymerase III (CHI subunit)
VRUMOI_RS02955	COG0795	lipopolysaccharide-transporting ATPase activity
VRUMOI_RS02960	COG0795	lipopolysaccharide-transporting ATPase activity
VRUMOI_RS02975	COG0463	Glycosyl transferase, family 2
VRUMOI_RS02985	COG1012	belongs to the aldehyde dehydrogenase family
VRUMOI_RS03045	COG0741	lytic transglycosylase activity
VRUMOI_RS03065	COG3383	formate dehydrogenase (NAD+) activity
VRUMOI_RS03070	COG2066	Belongs to the glutaminase family
VRUMOI_RS03075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VRUMOI_RS03080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VRUMOI_RS03090	COG1872	DUF167
VRUMOI_RS03095	COG0762	integral membrane protein
VRUMOI_RS03100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VRUMOI_RS03105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VRUMOI_RS03130	COG1678	Uncharacterized ACR, COG1678
VRUMOI_RS03135	COG0189	ligase activity
VRUMOI_RS03140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VRUMOI_RS03165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VRUMOI_RS03170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VRUMOI_RS03180	COG0191	fructose-bisphosphate aldolase activity
VRUMOI_RS03185	COG0668	transmembrane transport
VRUMOI_RS03195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VRUMOI_RS03200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VRUMOI_RS03205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VRUMOI_RS03215	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VRUMOI_RS03225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VRUMOI_RS03230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VRUMOI_RS03240	COG0354	folic acid binding
VRUMOI_RS03245	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VRUMOI_RS03250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VRUMOI_RS03255	COG1595	DNA-templated transcription, initiation
VRUMOI_RS03260	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VRUMOI_RS03270	COG3086	response to oxidative stress
VRUMOI_RS03275	COG0481	GTPase activity
VRUMOI_RS03285	COG0571	ribonuclease III activity
VRUMOI_RS03290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VRUMOI_RS03300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VRUMOI_RS03305	COG0736	holo-[acyl-carrier-protein] synthase activity
VRUMOI_RS03310	COG2433	Pfam Transposase IS66
VRUMOI_RS03325	COG3850	Histidine kinase
VRUMOI_RS03325	COG4999	Histidine kinase
VRUMOI_RS03325	COG2205	protein histidine kinase activity
VRUMOI_RS03325	COG3437	response regulator, receiver
VRUMOI_RS03330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VRUMOI_RS03335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VRUMOI_RS03340	COG3956	TIGRFAM MazG family protein
VRUMOI_RS03350	COG0148	phosphopyruvate hydratase activity
VRUMOI_RS03355	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VRUMOI_RS03365	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VRUMOI_RS03375	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VRUMOI_RS03385	COG1388	LysM domain
VRUMOI_RS03385	COG4942	peptidase
VRUMOI_RS03405	COG2433	Pfam Transposase IS66
VRUMOI_RS03415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VRUMOI_RS03425	COG2358	TRAP transporter, solute receptor (TAXI family
VRUMOI_RS03430	COG1546	Belongs to the CinA family
VRUMOI_RS03435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VRUMOI_RS03445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VRUMOI_RS03495	COG1238	metal cluster binding
VRUMOI_RS03500	COG0612	Peptidase, M16
VRUMOI_RS03505	COG2918	glutathione biosynthetic process
VRUMOI_RS03515	COG1854	S-ribosylhomocysteine lyase activity
VRUMOI_RS03520	COG4536	flavin adenine dinucleotide binding
VRUMOI_RS03525	COG4137	Cytochrome C assembly protein
VRUMOI_RS03530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VRUMOI_RS03540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VRUMOI_RS03545	COG0336	Belongs to the RNA methyltransferase TrmD family
VRUMOI_RS03560	COG0505	Belongs to the CarA family
VRUMOI_RS03565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VRUMOI_RS03570	COG2027	D-alanyl-D-alanine carboxypeptidase
VRUMOI_RS03575	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VRUMOI_RS03580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VRUMOI_RS03585	COG1534	Rna-binding protein
VRUMOI_RS03590	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VRUMOI_RS03595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VRUMOI_RS03600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VRUMOI_RS03605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VRUMOI_RS03610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VRUMOI_RS03625	COG0779	Required for maturation of 30S ribosomal subunits
VRUMOI_RS03630	COG0195	Participates in both transcription termination and antitermination
VRUMOI_RS03640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VRUMOI_RS03665	COG0826	peptidase U32
VRUMOI_RS03670	COG0826	peptidase U32
VRUMOI_RS03675	COG3154	lipid carrier protein
VRUMOI_RS03690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VRUMOI_RS03700	COG0084	hydrolase, TatD family'
VRUMOI_RS03705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VRUMOI_RS03710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VRUMOI_RS03715	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VRUMOI_RS03725	COG0813	purine-nucleoside phosphorylase activity
VRUMOI_RS03735	COG0560	Phosphoserine phosphatase
VRUMOI_RS03740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VRUMOI_RS03745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VRUMOI_RS03750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VRUMOI_RS03755	COG4628	conserved protein (DUF2132)
VRUMOI_RS03760	COG0402	S-adenosylhomocysteine deaminase activity
VRUMOI_RS03765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VRUMOI_RS03770	COG1022	Amp-dependent synthetase and ligase
VRUMOI_RS03775	COG4977	sequence-specific DNA binding
VRUMOI_RS03775	COG1917	Cupin 2, conserved barrel domain protein
VRUMOI_RS03790	COG2255	four-way junction helicase activity
VRUMOI_RS03800	COG4964	Belongs to the GSP D family
VRUMOI_RS03855	COG2059	Chromate
VRUMOI_RS03860	COG1929	Belongs to the glycerate kinase type-1 family
VRUMOI_RS03865	COG2610	gluconate transmembrane transporter activity
VRUMOI_RS03870	COG3835	regulator
VRUMOI_RS03875	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VRUMOI_RS03880	COG2171	N-acyltransferase activity
VRUMOI_RS03895	COG3141	response to X-ray
VRUMOI_RS03910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VRUMOI_RS03915	COG1074	ATP-dependent DNA helicase activity
VRUMOI_RS03920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VRUMOI_RS03925	COG2731	YhcH YjgK YiaL family protein
VRUMOI_RS03940	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VRUMOI_RS03945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VRUMOI_RS03950	COG2166	iron-sulfur cluster assembly
VRUMOI_RS03955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VRUMOI_RS03960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VRUMOI_RS03965	COG3248	Nucleoside-binding outer membrane protein
VRUMOI_RS03970	COG2211	Major facilitator Superfamily
VRUMOI_RS03975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VRUMOI_RS03985	COG2813	Specifically methylates the guanine in position
VRUMOI_RS03990	COG0271	Belongs to the BolA IbaG family
VRUMOI_RS03995	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VRUMOI_RS04005	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VRUMOI_RS04015	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VRUMOI_RS04020	COG2871	sodium ion transport
VRUMOI_RS04025	COG1477	protein flavinylation
VRUMOI_RS04035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VRUMOI_RS04040	COG2195	Cleaves the N-terminal amino acid of tripeptides
VRUMOI_RS04045	COG2252	PERMEase
VRUMOI_RS04050	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VRUMOI_RS04060	COG1073	alpha beta
VRUMOI_RS04070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VRUMOI_RS04075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VRUMOI_RS04080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VRUMOI_RS04085	COG0321	lipoyl(octanoyl) transferase activity
VRUMOI_RS04095	COG1686	Belongs to the peptidase S11 family
VRUMOI_RS04100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VRUMOI_RS04105	COG0772	Belongs to the SEDS family
VRUMOI_RS04110	COG0768	penicillin binding
VRUMOI_RS04115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VRUMOI_RS04120	COG0799	negative regulation of ribosome biogenesis
VRUMOI_RS04125	COG1466	dna polymerase III delta subunit
VRUMOI_RS04130	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VRUMOI_RS04135	COG0495	leucyl-tRNA aminoacylation
VRUMOI_RS04140	COG2888	peptidyl-tyrosine sulfation
VRUMOI_RS04145	COG3069	C4-dicarboxylate transmembrane transporter activity
VRUMOI_RS04155	COG1368	sulfuric ester hydrolase activity
VRUMOI_RS04160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VRUMOI_RS04165	COG4535	Mg2 and Co2 transporter CorC
VRUMOI_RS04175	COG1702	phosphate starvation-inducible protein PhoH
VRUMOI_RS04180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VRUMOI_RS04185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VRUMOI_RS04255	COG0193	aminoacyl-tRNA hydrolase activity
VRUMOI_RS04260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VRUMOI_RS04265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VRUMOI_RS04275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VRUMOI_RS04280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VRUMOI_RS04285	COG2890	protein-(glutamine-N5) methyltransferase activity
VRUMOI_RS04290	COG3094	Invasion gene expression up-regulator, SirB
VRUMOI_RS04295	COG2912	Transglutaminase-like superfamily
VRUMOI_RS04300	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VRUMOI_RS04310	COG0737	Belongs to the 5'-nucleotidase family
VRUMOI_RS04340	COG1131	(ABC) transporter
VRUMOI_RS04345	COG0842	Transport permease protein
VRUMOI_RS04350	COG1187	pseudouridine synthase activity
VRUMOI_RS04355	COG2840	Smr protein MutS2
VRUMOI_RS04375	COG2608	mercury ion transmembrane transporter activity
VRUMOI_RS04375	COG2217	Heavy metal translocating P-type atpase
VRUMOI_RS04400	COG0811	peptide transport
VRUMOI_RS04405	COG0811	peptide transport
VRUMOI_RS04410	COG0848	biopolymer transport protein
VRUMOI_RS04425	COG2207	Transcriptional regulator
VRUMOI_RS04425	COG3708	Transcriptional regulator
VRUMOI_RS04445	COG0443	Heat shock 70 kDa protein
VRUMOI_RS04455	COG0488	(ABC) transporter
VRUMOI_RS04480	COG1120	ATPase activity
VRUMOI_RS04490	COG1132	(ABC) transporter
VRUMOI_RS04505	COG3710	Transcriptional regulator
VRUMOI_RS04515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VRUMOI_RS04525	COG1233	COG1233 Phytoene dehydrogenase and related
VRUMOI_RS04530	COG0300	oxidoreductase activity
VRUMOI_RS04540	COG0415	Belongs to the DNA photolyase family
VRUMOI_RS04555	COG1595	DNA-templated transcription, initiation
VRUMOI_RS04560	COG4133	protoheme IX ABC transporter activity
VRUMOI_RS04565	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VRUMOI_RS04570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VRUMOI_RS04575	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VRUMOI_RS04580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VRUMOI_RS04585	COG1138	Cytochrome C-type biogenesis protein
VRUMOI_RS04590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VRUMOI_RS04605	COG2853	Lipoprotein
VRUMOI_RS04610	COG2067	long-chain fatty acid transport protein
VRUMOI_RS04620	COG1595	DNA-templated transcription, initiation
VRUMOI_RS04625	COG0183	Belongs to the thiolase family
VRUMOI_RS04630	COG1250	3-hydroxyacyl-CoA dehydrogenase
VRUMOI_RS04630	COG1024	Enoyl-CoA hydratase
VRUMOI_RS04635	COG1025	Belongs to the peptidase M16 family
VRUMOI_RS04640	COG2062	phosphohistidine phosphatase, SixA
VRUMOI_RS04645	COG2840	Smr protein MutS2
VRUMOI_RS04650	COG2890	protein-(glutamine-N5) methyltransferase activity
VRUMOI_RS04655	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VRUMOI_RS04660	COG4932	domain protein
VRUMOI_RS04660	COG5492	domain, Protein
VRUMOI_RS04675	COG2860	membrane
VRUMOI_RS04680	COG3101	peptidyl-lysine hydroxylation
VRUMOI_RS04695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VRUMOI_RS04695	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VRUMOI_RS04700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VRUMOI_RS04705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VRUMOI_RS04710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VRUMOI_RS04720	COG0101	tRNA pseudouridine synthase activity
VRUMOI_RS04725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VRUMOI_RS04730	COG0285	dihydrofolate synthase activity
VRUMOI_RS04735	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VRUMOI_RS04740	COG1286	toxin biosynthetic process
VRUMOI_RS04745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VRUMOI_RS04750	COG0583	DNA-binding transcription factor activity
VRUMOI_RS04755	COG0745	RESPONSE REGULATOR receiver
VRUMOI_RS04760	COG3335	DDE superfamily endonuclease
VRUMOI_RS04765	COG2832	Protein of unknown function (DUF454)
VRUMOI_RS04770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VRUMOI_RS04775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VRUMOI_RS04785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VRUMOI_RS04795	COG2983	Belongs to the UPF0260 family
VRUMOI_RS04810	COG2356	endonuclease I
VRUMOI_RS04815	COG2226	methyltransferase
VRUMOI_RS04820	COG0676	glucose-6-phosphate 1-epimerase activity
VRUMOI_RS04825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VRUMOI_RS04830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VRUMOI_RS04835	COG3139	Protein of unknown function (DUF1315)
VRUMOI_RS04840	COG0252	asparaginase activity
VRUMOI_RS04845	COG0616	signal peptide processing
VRUMOI_RS04850	COG0446	pyridine nucleotide-disulphide oxidoreductase
VRUMOI_RS04850	COG1902	pentaerythritol trinitrate reductase activity
VRUMOI_RS04855	COG0778	Nitroreductase
VRUMOI_RS04860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VRUMOI_RS04875	COG3706	GGDEF domain
VRUMOI_RS04885	COG3083	sulfuric ester hydrolase activity
VRUMOI_RS04890	COG3082	Protein of unknown function (DUF1414)
VRUMOI_RS04895	COG3081	Nucleoid-associated protein
VRUMOI_RS04900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VRUMOI_RS04905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VRUMOI_RS04910	COG2095	MarC family integral membrane protein
VRUMOI_RS04915	COG1012	belongs to the aldehyde dehydrogenase family
VRUMOI_RS04915	COG1454	alcohol dehydrogenase
VRUMOI_RS04930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VRUMOI_RS04940	COG2056	Na+-H+ antiporter family
VRUMOI_RS04950	COG0346	lactoylglutathione lyase activity
VRUMOI_RS04955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VRUMOI_RS04960	COG4660	Part of a membrane complex involved in electron transport
VRUMOI_RS04965	COG4659	FMN binding
VRUMOI_RS04975	COG4656	Part of a membrane complex involved in electron transport
VRUMOI_RS04980	COG2878	Part of a membrane complex involved in electron transport
VRUMOI_RS04985	COG4657	Part of a membrane complex involved in electron transport
VRUMOI_RS04995	COG0556	nucleotide-excision repair
VRUMOI_RS05000	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VRUMOI_RS05010	COG0521	Mo-molybdopterin cofactor biosynthetic process
VRUMOI_RS05020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VRUMOI_RS05025	COG0314	molybdopterin synthase activity
VRUMOI_RS05045	COG0601	transmembrane transport
VRUMOI_RS05050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VRUMOI_RS05065	COG3344	reverse transcriptase
VRUMOI_RS05080	COG0395	ABC-type sugar transport system, permease component
VRUMOI_RS05095	COG1609	Transcriptional regulator
VRUMOI_RS05110	COG1940	carbohydrate kinase activity
VRUMOI_RS05115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VRUMOI_RS05120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VRUMOI_RS05125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VRUMOI_RS05125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VRUMOI_RS05130	COG2723	6-phospho-beta-galactosidase activity
VRUMOI_RS05135	COG1447	Phosphotransferase system cellobiose-specific component IIA
VRUMOI_RS05140	COG1609	Transcriptional regulator
VRUMOI_RS05145	COG2723	6-phospho-beta-galactosidase activity
VRUMOI_RS05160	COG0435	Glutathione S-transferase
VRUMOI_RS05170	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VRUMOI_RS05210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VRUMOI_RS05225	COG1522	sequence-specific DNA binding
VRUMOI_RS05230	COG1946	Acyl-CoA thioesterase
VRUMOI_RS05245	COG2199	diguanylate cyclase activity
VRUMOI_RS05265	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VRUMOI_RS05275	COG2273	Hydrolase Family 16
VRUMOI_RS05280	COG5507	3-demethylubiquinone-9 3-methyltransferase
VRUMOI_RS05285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VRUMOI_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
VRUMOI_RS05320	COG1063	alcohol dehydrogenase
VRUMOI_RS05345	COG4667	esterase of the alpha-beta hydrolase superfamily
VRUMOI_RS05355	COG3153	acetyltransferase
VRUMOI_RS05355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VRUMOI_RS05360	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VRUMOI_RS05360	COG0517	IMP dehydrogenase activity
VRUMOI_RS05360	COG0617	tRNA 3'-terminal CCA addition
VRUMOI_RS05375	COG0537	adenosine 5'-monophosphoramidase activity
VRUMOI_RS05400	COG3150	esterase
VRUMOI_RS05405	COG1252	NADH dehydrogenase
VRUMOI_RS05420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VRUMOI_RS05425	COG4591	ABC-type transport system involved in lipoprotein release permease component
VRUMOI_RS05430	COG1136	(ABC) transporter
VRUMOI_RS05435	COG4591	ABC-type transport system involved in lipoprotein release permease component
VRUMOI_RS05445	COG2333	competence protein COMEC
VRUMOI_RS05445	COG0658	competence protein
VRUMOI_RS05450	COG1132	(ABC) transporter
VRUMOI_RS05455	COG1663	tetraacyldisaccharide 4'-kinase activity
VRUMOI_RS05460	COG2835	tetraacyldisaccharide 4'-kinase activity
VRUMOI_RS05470	COG0454	-acetyltransferase
VRUMOI_RS05485	COG0384	phenazine biosynthesis protein PhzF
VRUMOI_RS05490	COG2132	Multicopper oxidase
VRUMOI_RS05495	COG2719	SpoVR family
VRUMOI_RS05500	COG2718	Belongs to the UPF0229 family
VRUMOI_RS05505	COG2766	serine protein kinase
VRUMOI_RS05515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VRUMOI_RS05520	COG1882	Formate acetyltransferase
VRUMOI_RS05540	COG4160	amino acid transport
VRUMOI_RS05545	COG0708	Exodeoxyribonuclease III
VRUMOI_RS05550	COG2850	peptidyl-arginine hydroxylation
VRUMOI_RS05555	COG0456	acetyltransferase
VRUMOI_RS05560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VRUMOI_RS05565	COG2915	High frequency lysogenization protein hflD homolog
VRUMOI_RS05575	COG1187	pseudouridine synthase activity
VRUMOI_RS05585	COG1278	Cold shock
VRUMOI_RS05590	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VRUMOI_RS05595	COG0542	response to heat
VRUMOI_RS05600	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VRUMOI_RS05605	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VRUMOI_RS05610	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VRUMOI_RS05615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VRUMOI_RS05625	COG0539	negative regulation of cytoplasmic translation
VRUMOI_RS05630	COG0776	regulation of translation
VRUMOI_RS05635	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VRUMOI_RS05640	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VRUMOI_RS05645	COG0284	orotidine-5'-phosphate decarboxylase activity
VRUMOI_RS05655	COG0596	Alpha beta hydrolase
VRUMOI_RS05665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VRUMOI_RS05670	COG4136	ATPase activity
VRUMOI_RS05675	COG4135	transport system, permease component
VRUMOI_RS05680	COG4134	Bacterial extracellular solute-binding protein
VRUMOI_RS05685	COG1609	Transcriptional regulator
VRUMOI_RS05690	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VRUMOI_RS05695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VRUMOI_RS05700	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VRUMOI_RS05705	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VRUMOI_RS05740	COG1227	inorganic diphosphatase activity
VRUMOI_RS05750	COG0471	metal ion transport
VRUMOI_RS05760	COG4172	Belongs to the ABC transporter superfamily
VRUMOI_RS05770	COG4171	peptide transport system, permease
VRUMOI_RS05775	COG4168	peptide transport system, permease
VRUMOI_RS05780	COG0747	negative chemotaxis
VRUMOI_RS05785	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VRUMOI_RS05790	COG1842	Phage shock protein A
VRUMOI_RS05805	COG2818	Glycosylase
VRUMOI_RS05810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VRUMOI_RS05825	COG0626	cystathionine gamma-synthase activity
VRUMOI_RS05835	COG0733	neurotransmitter:sodium symporter activity
VRUMOI_RS05840	COG0564	pseudouridine synthase activity
VRUMOI_RS05845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VRUMOI_RS05855	COG0495	leucyl-tRNA aminoacylation
VRUMOI_RS05860	COG2350	Protein conserved in bacteria
VRUMOI_RS05885	COG0134	indole-3-glycerol-phosphate synthase activity
VRUMOI_RS05885	COG0135	phosphoribosylanthranilate isomerase activity
VRUMOI_RS05895	COG0512	Glutamine amidotransferase of anthranilate synthase
VRUMOI_RS05900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VRUMOI_RS05910	COG0009	L-threonylcarbamoyladenylate synthase
VRUMOI_RS05925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VRUMOI_RS05930	COG0417	DNA replication proofreading
VRUMOI_RS05935	COG2197	response regulator
VRUMOI_RS05940	COG0322	excinuclease ABC activity
VRUMOI_RS05975	COG1022	Amp-dependent synthetase and ligase
VRUMOI_RS06030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VRUMOI_RS06035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VRUMOI_RS06045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VRUMOI_RS06070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VRUMOI_RS06085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VRUMOI_RS06110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VRUMOI_RS06125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VRUMOI_RS06130	COG1448	Aminotransferase
VRUMOI_RS06170	COG2807	transmembrane transport
VRUMOI_RS06175	COG0861	Integral membrane protein TerC family
VRUMOI_RS06180	COG0017	Asparaginyl-tRNA synthetase
VRUMOI_RS06190	COG0251	oxidation-reduction process
VRUMOI_RS06195	COG1760	l-serine dehydratase
VRUMOI_RS06200	COG0814	amino acid
VRUMOI_RS06205	COG0494	nUDIX hydrolase
VRUMOI_RS06210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VRUMOI_RS06225	COG3106	COG3106 Predicted ATPase
VRUMOI_RS06230	COG3768	UPF0283 membrane protein
VRUMOI_RS06240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VRUMOI_RS06275	COG2824	Alkylphosphonate utilization operon protein PhnA
VRUMOI_RS06290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VRUMOI_RS06300	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VRUMOI_RS06305	COG0513	Belongs to the DEAD box helicase family
VRUMOI_RS06310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VRUMOI_RS06320	COG0488	(ABC) transporter
VRUMOI_RS06340	COG1482	cell wall glycoprotein biosynthetic process
VRUMOI_RS06345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VRUMOI_RS06345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VRUMOI_RS06345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VRUMOI_RS06350	COG2207	Transcriptional regulator
VRUMOI_RS06380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VRUMOI_RS06380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VRUMOI_RS06380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VRUMOI_RS06390	COG0561	phosphatase activity
VRUMOI_RS06395	COG3593	DNA synthesis involved in DNA repair
VRUMOI_RS06400	COG0737	Belongs to the 5'-nucleotidase family
VRUMOI_RS06405	COG0861	Integral membrane protein TerC family
VRUMOI_RS06415	COG0302	gtp cyclohydrolase
VRUMOI_RS06425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VRUMOI_RS06435	COG0545	Peptidyl-prolyl cis-trans isomerase
VRUMOI_RS06465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VRUMOI_RS06475	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VRUMOI_RS06480	COG0513	Belongs to the DEAD box helicase family
VRUMOI_RS06490	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VRUMOI_RS06495	COG0494	nUDIX hydrolase
VRUMOI_RS06500	COG0714	Associated with various cellular activities
VRUMOI_RS06505	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VRUMOI_RS06525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VRUMOI_RS06555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VRUMOI_RS06560	COG3038	cytochrome b561
VRUMOI_RS06570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VRUMOI_RS06575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VRUMOI_RS06600	COG2050	protein possibly involved in aromatic compounds catabolism
VRUMOI_RS06610	COG4533	DNA binding
VRUMOI_RS06630	COG0720	synthase
VRUMOI_RS06635	COG0602	queuosine metabolic process
VRUMOI_RS06645	COG3118	belongs to the thioredoxin family
VRUMOI_RS06650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VRUMOI_RS06685	COG0583	DNA-binding transcription factor activity
VRUMOI_RS06700	COG1181	Belongs to the D-alanine--D-alanine ligase family
VRUMOI_RS06710	COG0023	Translation Initiation Factor
VRUMOI_RS06715	COG0534	Mate efflux family protein
VRUMOI_RS06740	COG3639	organic phosphonate transmembrane transporter activity
VRUMOI_RS06750	COG0826	peptidase U32
VRUMOI_RS06755	COG2188	Transcriptional regulator
VRUMOI_RS06760	COG3624	Phosphonate C-P lyase system protein PhnG
VRUMOI_RS06765	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
VRUMOI_RS06770	COG3626	phosphonate metabolism
VRUMOI_RS06775	COG3627	carbon phosphorus lyase activity
VRUMOI_RS06780	COG4107	phosphonate C-P lyase system protein PhnK
VRUMOI_RS06785	COG4778	phosphonate C-P lyase system protein PhnL
VRUMOI_RS06790	COG3454	Phosphonate metabolism
VRUMOI_RS06795	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
VRUMOI_RS06800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VRUMOI_RS06865	COG1067	ATP-dependent peptidase activity
VRUMOI_RS06870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VRUMOI_RS06885	COG0488	(ABC) transporter
VRUMOI_RS06895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VRUMOI_RS06895	COG0116	Belongs to the methyltransferase superfamily
VRUMOI_RS06905	COG0167	dihydroorotate dehydrogenase activity
VRUMOI_RS06915	COG0308	aminopeptidase N
VRUMOI_RS06930	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VRUMOI_RS06935	COG1956	GAF domain-containing protein
VRUMOI_RS06940	COG1132	(ABC) transporter
VRUMOI_RS06945	COG2995	paraquat-inducible protein a
VRUMOI_RS06950	COG3008	intermembrane lipid transfer
VRUMOI_RS06955	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VRUMOI_RS06955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VRUMOI_RS06970	COG3647	Membrane
VRUMOI_RS06990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VRUMOI_RS06995	COG1666	GTP binding
VRUMOI_RS07000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VRUMOI_RS07010	COG1280	lysine exporter protein (LysE YggA)
VRUMOI_RS07050	COG1643	Atp-dependent helicase
VRUMOI_RS07070	COG0251	oxidation-reduction process
VRUMOI_RS07090	COG2925	Exonuclease
VRUMOI_RS07100	COG1346	cytolysis
VRUMOI_RS07105	COG0295	cytidine deaminase activity
VRUMOI_RS07110	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VRUMOI_RS07120	COG0776	regulation of translation
VRUMOI_RS07125	COG4166	transmembrane transport
VRUMOI_RS07135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VRUMOI_RS07135	COG0072	phenylalanine-tRNA ligase activity
VRUMOI_RS07145	COG2133	pyrroloquinoline quinone binding
VRUMOI_RS07170	COG0281	malic enzyme
VRUMOI_RS07175	COG2949	membrane
VRUMOI_RS07180	COG3706	GGDEF domain
VRUMOI_RS07200	COG3501	Rhs element vgr protein
VRUMOI_RS07220	COG0492	ferredoxin-NADP+ reductase activity
VRUMOI_RS07225	COG4988	ABC transporter
VRUMOI_RS07230	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VRUMOI_RS07235	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VRUMOI_RS07250	COG3070	regulator of competence-specific genes
VRUMOI_RS07255	COG2431	L-lysine efflux transmembrane transporter activity
VRUMOI_RS07265	COG0076	glutamate decarboxylase activity
VRUMOI_RS07270	COG1737	Transcriptional regulator
VRUMOI_RS07280	COG3273	potassium ion transport
VRUMOI_RS07280	COG2985	domain, Protein
VRUMOI_RS07290	COG2814	Major facilitator Superfamily
VRUMOI_RS07295	COG1028	Short-chain dehydrogenase reductase Sdr
VRUMOI_RS07305	COG0513	Belongs to the DEAD box helicase family
VRUMOI_RS07330	COG1960	acyl-CoA dehydrogenase activity
VRUMOI_RS07340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VRUMOI_RS07355	COG4181	ATPase activity
VRUMOI_RS07365	COG2814	Major facilitator Superfamily
VRUMOI_RS07375	COG2067	long-chain fatty acid transport protein
VRUMOI_RS07380	COG2267	carboxylic ester hydrolase activity
VRUMOI_RS07385	COG1061	Type III restriction enzyme res subunit
VRUMOI_RS07390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VRUMOI_RS07405	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VRUMOI_RS07410	COG1609	Transcriptional regulator
VRUMOI_RS07415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VRUMOI_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
VRUMOI_RS07430	COG3313	Fe-S protein
VRUMOI_RS07445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VRUMOI_RS07450	COG0583	DNA-binding transcription factor activity
VRUMOI_RS07465	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VRUMOI_RS07470	COG1032	radical SAM domain protein
VRUMOI_RS07480	COG0010	Belongs to the arginase family
VRUMOI_RS07485	COG1166	arginine decarboxylase activity
VRUMOI_RS07490	COG0668	transmembrane transport
VRUMOI_RS07495	COG3706	GGDEF domain
VRUMOI_RS07500	COG2755	lipolytic protein G-D-S-L family
VRUMOI_RS07500	COG0657	acetylesterase activity
VRUMOI_RS07505	COG2828	Protein conserved in bacteria
VRUMOI_RS07510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VRUMOI_RS07515	COG0372	Belongs to the citrate synthase family
VRUMOI_RS07520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VRUMOI_RS07525	COG2186	Transcriptional regulator
VRUMOI_RS07555	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VRUMOI_RS07580	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VRUMOI_RS07585	COG2885	chlorophyll binding
VRUMOI_RS07590	COG0823	Involved in the tonB-independent uptake of proteins
VRUMOI_RS07600	COG0848	biopolymer transport protein
VRUMOI_RS07605	COG0811	peptide transport
VRUMOI_RS07610	COG0824	Thioesterase
VRUMOI_RS07620	COG4890	Cyd operon protein YbgT
VRUMOI_RS07625	COG1294	oxidase, subunit
VRUMOI_RS07630	COG1271	oxidase subunit
VRUMOI_RS07635	COG2255	four-way junction helicase activity
VRUMOI_RS07640	COG0632	four-way junction helicase activity
VRUMOI_RS07650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VRUMOI_RS07655	COG4106	trans-aconitate 2-methyltransferase activity
VRUMOI_RS07660	COG0500	methyltransferase
VRUMOI_RS07665	COG4067	protein conserved in archaea
VRUMOI_RS07665	COG0189	ligase activity
VRUMOI_RS07680	COG1435	thymidine kinase activity
VRUMOI_RS07685	COG0215	cysteine-tRNA ligase activity
VRUMOI_RS07690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VRUMOI_RS07695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VRUMOI_RS07700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VRUMOI_RS07705	COG3012	SEC-C Motif Domain Protein
VRUMOI_RS07715	COG1566	PFAM secretion protein HlyD family protein
VRUMOI_RS07725	COG0140	phosphoribosyl-ATP diphosphatase activity
VRUMOI_RS07725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VRUMOI_RS07735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VRUMOI_RS07740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VRUMOI_RS07745	COG0131	Imidazoleglycerol-phosphate dehydratase
VRUMOI_RS07745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VRUMOI_RS07750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VRUMOI_RS07755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VRUMOI_RS07760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VRUMOI_RS07765	COG1757	Na H antiporter
VRUMOI_RS07770	COG3335	DDE superfamily endonuclease
VRUMOI_RS07780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VRUMOI_RS07785	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VRUMOI_RS07795	COG1199	ATP-dependent helicase activity
VRUMOI_RS07800	COG0730	response to heat
VRUMOI_RS07815	COG0501	Belongs to the peptidase M48B family
VRUMOI_RS07820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VRUMOI_RS07845	COG0189	ligase activity
VRUMOI_RS07845	COG4067	protein conserved in archaea
VRUMOI_RS07850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VRUMOI_RS07855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VRUMOI_RS07860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VRUMOI_RS07865	COG1674	ftsk spoiiie
VRUMOI_RS07870	COG1522	sequence-specific DNA binding
VRUMOI_RS07875	COG0686	Belongs to the AlaDH PNT family
VRUMOI_RS07895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VRUMOI_RS07910	COG3335	DDE superfamily endonuclease
VRUMOI_RS07920	COG0616	signal peptide processing
VRUMOI_RS07925	COG1028	Short-chain dehydrogenase reductase Sdr
VRUMOI_RS07930	COG1940	carbohydrate kinase activity
VRUMOI_RS07935	COG0469	pyruvate kinase activity
VRUMOI_RS07945	COG4667	esterase of the alpha-beta hydrolase superfamily
VRUMOI_RS07950	COG0733	neurotransmitter:sodium symporter activity
VRUMOI_RS07970	COG1263	PTS System
VRUMOI_RS07970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VRUMOI_RS07970	COG2190	(PTS) system
VRUMOI_RS07975	COG0084	hydrolase, TatD family'
VRUMOI_RS07980	COG0470	DNA polymerase III
VRUMOI_RS07985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VRUMOI_RS07990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VRUMOI_RS07995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VRUMOI_RS08000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VRUMOI_RS08020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VRUMOI_RS08035	COG1399	metal-binding, possibly nucleic acid-binding protein
VRUMOI_RS08040	COG0424	maF-like protein
VRUMOI_RS08045	COG0564	pseudouridine synthase activity
VRUMOI_RS08050	COG1530	ribonuclease E activity
VRUMOI_RS08055	COG0659	secondary active sulfate transmembrane transporter activity
VRUMOI_RS08060	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VRUMOI_RS08065	COG2982	Protein involved in outer membrane biogenesis
VRUMOI_RS08075	COG0572	uridine kinase
VRUMOI_RS08080	COG0489	protein tyrosine kinase activity
VRUMOI_RS08085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VRUMOI_RS08085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VRUMOI_RS08100	COG2186	Transcriptional regulator
VRUMOI_RS08110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VRUMOI_RS08115	COG0653	protein targeting
VRUMOI_RS08120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VRUMOI_RS08125	COG3706	GGDEF domain
VRUMOI_RS08130	COG1122	ATPase activity
VRUMOI_RS08135	COG4120	Belongs to the binding-protein-dependent transport system permease family
VRUMOI_RS08150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VRUMOI_RS08155	COG0280	phosphate acetyltransferase
VRUMOI_RS08155	COG0857	belongs to the CobB CobQ family
VRUMOI_RS08185	COG2855	membrane
VRUMOI_RS08200	COG2267	carboxylic ester hydrolase activity
VRUMOI_RS08205	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VRUMOI_RS08210	COG1169	isochorismate synthase
VRUMOI_RS08215	COG0436	Aminotransferase
VRUMOI_RS08220	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VRUMOI_RS08225	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VRUMOI_RS08240	COG1555	photosystem II stabilization
VRUMOI_RS08245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VRUMOI_RS08250	COG0776	regulation of translation
VRUMOI_RS08255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VRUMOI_RS08260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VRUMOI_RS08275	COG3842	ATPase activity
VRUMOI_RS08280	COG0395	ABC-type sugar transport system, permease component
VRUMOI_RS08285	COG1175	transmembrane transport
VRUMOI_RS08320	COG0814	amino acid
VRUMOI_RS08340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VRUMOI_RS08345	COG1971	Probably functions as a manganese efflux pump
VRUMOI_RS08350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VRUMOI_RS08355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VRUMOI_RS08360	COG2951	lytic endotransglycosylase activity
VRUMOI_RS08365	COG3100	YcgL domain-containing protein
VRUMOI_RS08370	COG0850	regulation of cytokinetic process
VRUMOI_RS08375	COG2894	cell division
VRUMOI_RS08380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VRUMOI_RS08385	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VRUMOI_RS08390	COG0318	PFAM AMP-dependent synthetase and ligase
VRUMOI_RS08395	COG0596	Alpha beta hydrolase
VRUMOI_RS08405	COG1214	PFAM Peptidase M22, glycoprotease
VRUMOI_RS08410	COG1199	ATP-dependent helicase activity
VRUMOI_RS08415	COG0788	formyltetrahydrofolate deformylase activity
VRUMOI_RS08420	COG3102	Protein conserved in bacteria
VRUMOI_RS08435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VRUMOI_RS08440	COG1918	ferrous iron import across plasma membrane
VRUMOI_RS08450	COG0739	heme binding
VRUMOI_RS08455	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VRUMOI_RS08460	COG1121	(ABC) transporter
VRUMOI_RS08465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VRUMOI_RS08490	COG0508	dehydrogenase complex catalyzes the overall conversion of
VRUMOI_RS08495	COG0567	Dehydrogenase, E1 component
VRUMOI_RS08505	COG1053	succinate dehydrogenase
VRUMOI_RS08510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VRUMOI_RS08525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VRUMOI_RS08535	COG0033	Phosphoglucomutase
VRUMOI_RS08540	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VRUMOI_RS08545	COG3258	Cytochrome c
VRUMOI_RS08550	COG2863	cytochrome
VRUMOI_RS08555	COG0596	Alpha beta hydrolase
VRUMOI_RS08565	COG0716	FMN binding
VRUMOI_RS08570	COG0735	belongs to the Fur family
VRUMOI_RS08575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VRUMOI_RS08580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VRUMOI_RS08580	COG2190	(PTS) system
VRUMOI_RS08580	COG1263	PTS System
VRUMOI_RS08590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VRUMOI_RS08595	COG1846	Transcriptional regulator
VRUMOI_RS08595	COG1940	carbohydrate kinase activity
VRUMOI_RS08605	COG0367	asparagine synthase
VRUMOI_RS08615	COG3104	oligopeptide transport
VRUMOI_RS08620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VRUMOI_RS08625	COG0563	adenylate kinase activity
VRUMOI_RS08630	COG0326	Molecular chaperone. Has ATPase activity
VRUMOI_RS08635	COG3710	Transcriptional regulator
VRUMOI_RS08650	COG0622	Phosphoesterase
VRUMOI_RS08655	COG1090	epimerase
VRUMOI_RS08660	COG3118	belongs to the thioredoxin family
VRUMOI_RS08665	COG0789	Transcriptional regulator
VRUMOI_RS08680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VRUMOI_RS08685	COG3115	cell septum assembly
VRUMOI_RS08690	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VRUMOI_RS08700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VRUMOI_RS08710	COG2190	(PTS) system
VRUMOI_RS08715	COG2837	iron assimilation
VRUMOI_RS08735	COG1393	Belongs to the ArsC family
VRUMOI_RS08760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VRUMOI_RS08765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VRUMOI_RS08775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VRUMOI_RS08790	COG4783	chaperone-mediated protein folding
VRUMOI_RS08795	COG1393	Belongs to the ArsC family
VRUMOI_RS08810	COG0583	DNA-binding transcription factor activity
VRUMOI_RS08815	COG2130	NADP-dependent
VRUMOI_RS08820	COG1979	alcohol dehydrogenase
VRUMOI_RS08830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VRUMOI_RS08840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VRUMOI_RS08845	COG0121	glutamine amidotransferase
VRUMOI_RS08850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VRUMOI_RS08855	COG1960	acyl-CoA dehydrogenase activity
VRUMOI_RS08860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VRUMOI_RS08865	COG0328	RNA-DNA hybrid ribonuclease activity
VRUMOI_RS08870	COG2226	methyltransferase
VRUMOI_RS08875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VRUMOI_RS08880	COG0741	lytic transglycosylase activity
VRUMOI_RS08880	COG1388	LysM domain
VRUMOI_RS08885	COG3021	interspecies interaction between organisms
VRUMOI_RS08890	COG0347	Belongs to the P(II) protein family
VRUMOI_RS08895	COG0037	tRNA processing
VRUMOI_RS08900	COG0825	malonyl-CoA metabolic process
VRUMOI_RS08905	COG0587	DNA-directed DNA polymerase activity
VRUMOI_RS08915	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VRUMOI_RS08920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VRUMOI_RS08930	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VRUMOI_RS08935	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VRUMOI_RS08945	COG0750	zinc metalloprotease
VRUMOI_RS08950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VRUMOI_RS08955	COG0575	Belongs to the CDS family
VRUMOI_RS08960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VRUMOI_RS08965	COG0233	cytoplasmic translational termination
VRUMOI_RS08985	COG0024	Methionine aminopeptidase
VRUMOI_RS08990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VRUMOI_RS09000	COG0564	pseudouridine synthase activity
VRUMOI_RS09005	COG3098	single-species biofilm formation
VRUMOI_RS09025	COG1671	Belongs to the UPF0178 family
VRUMOI_RS09030	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VRUMOI_RS09040	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VRUMOI_RS09040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VRUMOI_RS09050	COG1611	Belongs to the LOG family
VRUMOI_RS09060	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VRUMOI_RS09065	COG2363	Small membrane protein
VRUMOI_RS09080	COG0301	tRNA thio-modification
VRUMOI_RS09080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VRUMOI_RS09090	COG0142	geranyltranstransferase activity
VRUMOI_RS09095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VRUMOI_RS09105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VRUMOI_RS09110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VRUMOI_RS09115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VRUMOI_RS09135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VRUMOI_RS09135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VRUMOI_RS09140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VRUMOI_RS09165	COG4608	Belongs to the ABC transporter superfamily
VRUMOI_RS09170	COG0444	Belongs to the ABC transporter superfamily
VRUMOI_RS09175	COG4166	transmembrane transport
VRUMOI_RS09180	COG4239	(ABC) transporter, permease
VRUMOI_RS09185	COG4174	ABC transporter (Permease)
VRUMOI_RS09195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VRUMOI_RS09200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VRUMOI_RS09205	COG2011	ABC-type metal ion transport system permease component
VRUMOI_RS09215	COG1464	Belongs to the NlpA lipoprotein family
VRUMOI_RS09225	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VRUMOI_RS09230	COG1720	tRNA m6t6A37 methyltransferase activity
VRUMOI_RS09235	COG0442	prolyl-tRNA aminoacylation
VRUMOI_RS09240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VRUMOI_RS09275	COG0514	ATP-dependent DNA helicase (RecQ)
VRUMOI_RS09290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VRUMOI_RS09290	COG0047	phosphoribosylformylglycinamidine synthase activity
VRUMOI_RS09295	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VRUMOI_RS09300	COG0590	tRNA wobble adenosine to inosine editing
VRUMOI_RS09335	COG0484	heat shock protein binding
VRUMOI_RS09340	COG0443	Heat shock 70 kDa protein
VRUMOI_RS09345	COG0667	Aldo Keto reductase
VRUMOI_RS09350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VRUMOI_RS09355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VRUMOI_RS09360	COG0497	DNA recombination
VRUMOI_RS09365	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VRUMOI_RS09370	COG2914	Belongs to the UPF0125 (RnfH) family
VRUMOI_RS09375	COG2867	negative regulation of translational initiation
VRUMOI_RS09400	COG3634	alkyl hydroperoxide reductase activity
VRUMOI_RS09415	COG0109	protoheme IX farnesyltransferase activity
VRUMOI_RS09420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VRUMOI_RS09425	COG1845	cytochrome c oxidase, subunit III
VRUMOI_RS09430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VRUMOI_RS09435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VRUMOI_RS09455	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VRUMOI_RS09460	COG0583	DNA-binding transcription factor activity
VRUMOI_RS09475	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VRUMOI_RS09480	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VRUMOI_RS09485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VRUMOI_RS09490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VRUMOI_RS09495	COG1116	anion transmembrane transporter activity
VRUMOI_RS09505	COG3547	Transposase (IS116 IS110 IS902 family)
VRUMOI_RS09515	COG0745	RESPONSE REGULATOR receiver
VRUMOI_RS09520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VRUMOI_RS09525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VRUMOI_RS09535	COG0454	-acetyltransferase
VRUMOI_RS09540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VRUMOI_RS09540	COG0519	Catalyzes the synthesis of GMP from XMP
VRUMOI_RS09545	COG0517	IMP dehydrogenase activity
VRUMOI_RS09545	COG0516	GMP reductase activity
VRUMOI_RS09550	COG1570	exodeoxyribonuclease VII activity
VRUMOI_RS09555	COG5001	Diguanylate cyclase
VRUMOI_RS09555	COG3300	MHYT domain
VRUMOI_RS09565	COG1160	GTP binding
VRUMOI_RS09570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VRUMOI_RS09575	COG2976	Protein conserved in bacteria
VRUMOI_RS09580	COG0124	histidyl-tRNA synthetase
VRUMOI_RS09590	COG1426	Protein conserved in bacteria
VRUMOI_RS09605	COG0105	UTP biosynthetic process
VRUMOI_RS09610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VRUMOI_RS09615	COG2975	iron-sulfur cluster assembly
VRUMOI_RS09620	COG0633	Ferredoxin
VRUMOI_RS09625	COG0443	Heat shock 70 kDa protein
VRUMOI_RS09630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VRUMOI_RS09640	COG0822	iron-sulfur transferase activity
VRUMOI_RS09645	COG1104	cysteine desulfurase activity
VRUMOI_RS09660	COG0483	inositol monophosphate 1-phosphatase activity
VRUMOI_RS09665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VRUMOI_RS09670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VRUMOI_RS09675	COG1862	Preprotein translocase
VRUMOI_RS09685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VRUMOI_RS09690	COG0583	DNA-binding transcription factor activity
VRUMOI_RS09695	COG3335	DDE superfamily endonuclease
VRUMOI_RS09700	COG0450	alkyl hydroperoxide reductase
VRUMOI_RS09705	COG3142	Participates in the control of copper homeostasis
VRUMOI_RS09710	COG0704	Plays a role in the regulation of phosphate uptake
VRUMOI_RS09715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VRUMOI_RS09720	COG0581	inorganic phosphate transmembrane transporter activity
VRUMOI_RS09725	COG0573	inorganic phosphate transmembrane transporter activity
VRUMOI_RS09730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VRUMOI_RS09735	COG0248	Ppx GppA phosphatase
VRUMOI_RS09745	COG5002	protein histidine kinase activity
VRUMOI_RS09750	COG0745	RESPONSE REGULATOR receiver
VRUMOI_RS09755	COG2974	May be involved in recombination
VRUMOI_RS09760	COG0826	peptidase U32
VRUMOI_RS09765	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VRUMOI_RS09825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VRUMOI_RS09830	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
VRUMOI_RS09835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VRUMOI_RS09840	COG0590	tRNA wobble adenosine to inosine editing
VRUMOI_RS09850	COG0542	response to heat
VRUMOI_RS09855	COG1496	oxidoreductase activity
VRUMOI_RS09860	COG0564	pseudouridine synthase activity
VRUMOI_RS09865	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VRUMOI_RS09870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VRUMOI_RS09875	COG0077	Prephenate dehydratase
VRUMOI_RS09875	COG1605	Chorismate mutase
VRUMOI_RS09885	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VRUMOI_RS09895	COG0488	(ABC) transporter
VRUMOI_RS09900	COG1196	nuclear chromosome segregation
VRUMOI_RS09900	COG0741	lytic transglycosylase activity
VRUMOI_RS09900	COG0739	heme binding
VRUMOI_RS09905	COG0287	Prephenate dehydrogenase
VRUMOI_RS09905	COG1605	Chorismate mutase
VRUMOI_RS09915	COG3275	phosphorelay sensor kinase activity
VRUMOI_RS09920	COG3279	Response regulator of the LytR AlgR family
VRUMOI_RS09925	COG0569	domain protein
VRUMOI_RS09925	COG0189	ligase activity
VRUMOI_RS09945	COG1966	Carbon starvation protein
VRUMOI_RS09965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VRUMOI_RS09990	COG2205	protein histidine kinase activity
VRUMOI_RS09995	COG0745	RESPONSE REGULATOR receiver
VRUMOI_RS10015	COG2217	Heavy metal translocating P-type atpase
VRUMOI_RS10020	COG0789	Transcriptional regulator
VRUMOI_RS10035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VRUMOI_RS10040	COG1047	Peptidyl-prolyl cis-trans
VRUMOI_RS10045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VRUMOI_RS10050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VRUMOI_RS10055	COG0196	riboflavin kinase activity
VRUMOI_RS10060	COG0728	peptidoglycan biosynthetic process
VRUMOI_RS10065	COG0268	Binds directly to 16S ribosomal RNA
VRUMOI_RS10070	COG0640	Transcriptional regulator
VRUMOI_RS10075	COG0583	DNA-binding transcription factor activity
VRUMOI_RS10080	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VRUMOI_RS10110	COG0667	Aldo Keto reductase
VRUMOI_RS10130	COG3604	Transcriptional regulator
VRUMOI_RS10135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VRUMOI_RS10145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VRUMOI_RS10150	COG3097	Belongs to the UPF0267 family
VRUMOI_RS10155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VRUMOI_RS10160	COG4974	Belongs to the 'phage' integrase family
VRUMOI_RS10165	COG0716	FMN binding
VRUMOI_RS10180	COG0513	Belongs to the DEAD box helicase family
VRUMOI_RS10185	COG3022	response to hydroperoxide
VRUMOI_RS10190	COG1115	amino acid carrier protein
VRUMOI_RS10210	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VRUMOI_RS10215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VRUMOI_RS10220	COG0083	homoserine kinase activity
VRUMOI_RS10230	COG0745	RESPONSE REGULATOR receiver
VRUMOI_RS10235	COG0784	Response regulator, receiver
VRUMOI_RS10235	COG5002	protein histidine kinase activity
VRUMOI_RS10235	COG2198	Histidine kinase
VRUMOI_RS10245	COG0070	glutamate synthase
VRUMOI_RS10245	COG0067	glutamate synthase
VRUMOI_RS10245	COG0069	glutamate synthase activity
VRUMOI_RS10265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VRUMOI_RS10270	COG2860	membrane
VRUMOI_RS10275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VRUMOI_RS10280	COG0739	heme binding
VRUMOI_RS10285	COG0316	Belongs to the HesB IscA family
VRUMOI_RS10290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VRUMOI_RS10325	COG0747	negative chemotaxis
VRUMOI_RS10335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VRUMOI_RS10340	COG0444	Belongs to the ABC transporter superfamily
VRUMOI_RS10345	COG4608	Belongs to the ABC transporter superfamily
VRUMOI_RS10355	COG2971	BadF BadG BcrA BcrD
VRUMOI_RS10370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VRUMOI_RS10375	COG2814	Major facilitator Superfamily
VRUMOI_RS10385	COG0693	protein deglycase activity
VRUMOI_RS10390	COG3842	ATPase activity
VRUMOI_RS10400	COG1840	ABC-type Fe3 transport system, periplasmic component
VRUMOI_RS10405	COG0004	ammonium transporteR
VRUMOI_RS10410	COG0347	Belongs to the P(II) protein family
VRUMOI_RS10415	COG3112	Uncharacterised protein family (UPF0231)
VRUMOI_RS10420	COG1049	propionate catabolic process, 2-methylcitrate cycle
VRUMOI_RS10425	COG1752	Esterase of the alpha-beta hydrolase superfamily
VRUMOI_RS10430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VRUMOI_RS10435	COG1643	Atp-dependent helicase
VRUMOI_RS10445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VRUMOI_RS10450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VRUMOI_RS10460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VRUMOI_RS10465	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VRUMOI_RS10475	COG0842	Transport permease protein
VRUMOI_RS10480	COG1131	(ABC) transporter
VRUMOI_RS10485	COG0288	reversible hydration of carbon dioxide
VRUMOI_RS10500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VRUMOI_RS10505	COG0508	dehydrogenase complex catalyzes the overall conversion of
VRUMOI_RS10510	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VRUMOI_RS10515	COG2186	Transcriptional regulator
VRUMOI_RS10525	COG0157	Belongs to the NadC ModD family
VRUMOI_RS10540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VRUMOI_RS10545	COG1459	type II secretion system
VRUMOI_RS10555	COG0237	dephospho-CoA kinase activity
VRUMOI_RS10560	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VRUMOI_RS10570	COG0494	nUDIX hydrolase
VRUMOI_RS10575	COG0653	protein targeting
VRUMOI_RS10585	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VRUMOI_RS10590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VRUMOI_RS10595	COG0849	cell division
VRUMOI_RS10600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VRUMOI_RS10605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VRUMOI_RS10610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VRUMOI_RS10615	COG0772	Belongs to the SEDS family
VRUMOI_RS10620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VRUMOI_RS10625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VRUMOI_RS10630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VRUMOI_RS10635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VRUMOI_RS10640	COG0768	penicillin binding
VRUMOI_RS10645	COG3116	cell division
VRUMOI_RS10660	COG2706	6-phosphogluconolactonase activity
VRUMOI_RS10665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VRUMOI_RS10670	COG3107	peptidoglycan biosynthetic process
VRUMOI_RS10675	COG0792	nuclease activity
VRUMOI_RS10680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VRUMOI_RS10755	COG0175	sulfate reduction
VRUMOI_RS10760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VRUMOI_RS10765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VRUMOI_RS10785	COG0735	belongs to the Fur family
VRUMOI_RS10800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VRUMOI_RS10825	COG2965	DNA replication, synthesis of RNA primer
VRUMOI_RS10835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VRUMOI_RS10840	COG0557	exoribonuclease II activity
VRUMOI_RS10845	COG1959	2 iron, 2 sulfur cluster binding
VRUMOI_RS10850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VRUMOI_RS10850	COG1017	nitric oxide dioxygenase activity
VRUMOI_RS10855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VRUMOI_RS10860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VRUMOI_RS10865	COG0330	HflC and HflK could
VRUMOI_RS10870	COG0330	HflC and HflK could
VRUMOI_RS10875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VRUMOI_RS10885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VRUMOI_RS10890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VRUMOI_RS10900	COG0802	atpase or kinase
VRUMOI_RS10905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VRUMOI_RS10955	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VRUMOI_RS10960	COG1162	GTPase activity
VRUMOI_RS10965	COG0688	phosphatidylethanolamine metabolic process
VRUMOI_RS10980	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VRUMOI_RS10985	COG1053	succinate dehydrogenase
VRUMOI_RS10990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VRUMOI_RS10995	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VRUMOI_RS11005	COG0803	Belongs to the bacterial solute-binding protein 9 family
VRUMOI_RS11010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VRUMOI_RS11025	COG3683	transport system, periplasmic component
VRUMOI_RS11030	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
VRUMOI_RS11035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VRUMOI_RS11040	COG1509	lysine 2,3-aminomutase activity
VRUMOI_RS11050	COG3609	addiction module antidote protein, CC2985 family
VRUMOI_RS11060	COG0604	alcohol dehydrogenase
VRUMOI_RS11065	COG1285	pathogenesis
VRUMOI_RS11070	COG1119	ATPase activity
VRUMOI_RS11075	COG3344	reverse transcriptase
VRUMOI_RS11080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VRUMOI_RS11080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VRUMOI_RS11080	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VRUMOI_RS11085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VRUMOI_RS11090	COG4533	DNA binding
VRUMOI_RS11100	COG3344	reverse transcriptase
VRUMOI_RS11110	COG0459	protein refolding
VRUMOI_RS11115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VRUMOI_RS11120	COG0534	Mate efflux family protein
VRUMOI_RS11125	COG1045	serine acetyltransferase
VRUMOI_RS11140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VRUMOI_RS11145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VRUMOI_RS11150	COG4942	peptidase
VRUMOI_RS11195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VRUMOI_RS11270	COG3550	peptidyl-serine autophosphorylation
VRUMOI_RS11315	COG4598	ABC transporter
VRUMOI_RS11320	COG0765	amino acid transport
VRUMOI_RS11325	COG0765	amino acid transport
VRUMOI_RS11340	COG0583	DNA-binding transcription factor activity
VRUMOI_RS11375	COG3550	peptidyl-serine autophosphorylation
VRUMOI_RS11385	COG2822	iron ion transport
VRUMOI_RS11390	COG2837	iron assimilation
VRUMOI_RS11395	COG0672	)-iron permease
VRUMOI_RS11425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VRUMOI_RS11435	COG1070	Carbohydrate kinase
VRUMOI_RS11440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VRUMOI_RS11445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VRUMOI_RS11455	COG1172	Belongs to the binding-protein-dependent transport system permease family
VRUMOI_RS11460	COG1129	ABC transporter
VRUMOI_RS11470	COG1349	DNA-binding transcription factor activity
VRUMOI_RS11495	COG3550	peptidyl-serine autophosphorylation
VRUMOI_RS11520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VRUMOI_RS11540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VRUMOI_RS11540	COG0517	IMP dehydrogenase activity
VRUMOI_RS11550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VRUMOI_RS11555	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VRUMOI_RS11565	COG0463	Glycosyl transferase, family 2
VRUMOI_RS11565	COG1216	Glycosyl transferase, family 2
VRUMOI_RS11590	COG5433	transposase activity
VRUMOI_RS11600	COG5433	transposase activity
VRUMOI_RS11605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VRUMOI_RS11620	COG1560	Kdo2-lipid A biosynthetic process
VRUMOI_RS11640	COG0463	Glycosyl transferase, family 2
VRUMOI_RS11650	COG1519	Transferase
VRUMOI_RS11655	COG3083	sulfuric ester hydrolase activity
VRUMOI_RS11660	COG3642	lipopolysaccharide core region biosynthetic process
VRUMOI_RS11670	COG0859	PFAM glycosyl transferase family 9
VRUMOI_RS11680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VRUMOI_RS11685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VRUMOI_RS11690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VRUMOI_RS11695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VRUMOI_RS11705	COG2003	Belongs to the UPF0758 family
VRUMOI_RS11710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VRUMOI_RS11715	COG0756	dUTP diphosphatase activity
VRUMOI_RS11720	COG1309	transcriptional regulator
VRUMOI_RS11725	COG1560	Kdo2-lipid A biosynthetic process
VRUMOI_RS11730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VRUMOI_RS11735	COG2233	PERMEase
VRUMOI_RS11740	COG3547	Transposase (IS116 IS110 IS902 family)
VRUMOI_RS11745	COG3328	transposase activity
VRUMOI_RS11760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VRUMOI_RS11765	COG2183	response to ionizing radiation
VRUMOI_RS11775	COG0584	glycerophosphoryl diester phosphodiesterase
VRUMOI_RS11780	COG2271	Major facilitator Superfamily
VRUMOI_RS11790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VRUMOI_RS11795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VRUMOI_RS11800	COG1349	DNA-binding transcription factor activity
VRUMOI_RS11810	COG1040	competence protein
VRUMOI_RS11820	COG1218	3'(2'),5'-bisphosphate nucleotidase
VRUMOI_RS11825	COG0494	nUDIX hydrolase
VRUMOI_RS11835	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VRUMOI_RS11840	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VRUMOI_RS11845	COG3156	type II secretion system protein K
VRUMOI_RS11850	COG4795	General secretion pathway protein
VRUMOI_RS11855	COG2165	general secretion pathway protein
VRUMOI_RS11860	COG2165	general secretion pathway protein
VRUMOI_RS11865	COG2165	general secretion pathway protein
VRUMOI_RS11870	COG1459	type II secretion system
VRUMOI_RS11875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VRUMOI_RS11885	COG3031	protein transport across the cell outer membrane
VRUMOI_RS11890	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VRUMOI_RS11895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VRUMOI_RS11900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VRUMOI_RS11910	COG0456	acetyltransferase
VRUMOI_RS11915	COG1490	D-aminoacyl-tRNA deacylase activity
VRUMOI_RS11920	COG1295	ribonuclease BN
VRUMOI_RS11925	COG1217	gtp-binding protein TYPA
VRUMOI_RS11930	COG0174	glutamine synthetase
VRUMOI_RS11940	COG3852	Histidine kinase
VRUMOI_RS11945	COG2204	response regulator
VRUMOI_RS11950	COG5001	Diguanylate cyclase
VRUMOI_RS11950	COG3300	MHYT domain
VRUMOI_RS11980	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VRUMOI_RS11985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VRUMOI_RS11985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VRUMOI_RS11990	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VRUMOI_RS12000	COG0514	ATP-dependent DNA helicase (RecQ)
VRUMOI_RS12005	COG2962	Rard protein
VRUMOI_RS12010	COG1280	lysine exporter protein (LysE YggA)
VRUMOI_RS12020	COG0745	RESPONSE REGULATOR receiver
VRUMOI_RS12025	COG2205	protein histidine kinase activity
VRUMOI_RS12030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VRUMOI_RS12035	COG3030	protein affecting phage T7 exclusion by the F plasmid
VRUMOI_RS12040	COG1027	Aspartate ammonia-lyase
VRUMOI_RS12045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VRUMOI_RS12050	COG4232	protein-disulfide reductase activity
VRUMOI_RS12060	COG3263	regulation of cellular component size
VRUMOI_RS12065	COG2095	MarC family integral membrane protein
VRUMOI_RS12075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VRUMOI_RS12085	COG2205	protein histidine kinase activity
VRUMOI_RS12090	COG2814	Major facilitator Superfamily
VRUMOI_RS12105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VRUMOI_RS12110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VRUMOI_RS12115	COG0511	ligase activity, forming carbon-carbon bonds
VRUMOI_RS12120	COG0439	Biotin carboxylase
VRUMOI_RS12125	COG3924	membrane
VRUMOI_RS12130	COG4145	pantothenate transmembrane transporter activity
VRUMOI_RS12135	COG2264	protein methyltransferase activity
VRUMOI_RS12140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VRUMOI_RS12145	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VRUMOI_RS12150	COG1609	Transcriptional regulator
VRUMOI_RS12160	COG2169	Transcriptional regulator
VRUMOI_RS12160	COG1917	Cupin 2, conserved barrel domain protein
VRUMOI_RS12170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VRUMOI_RS12175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VRUMOI_RS12175	COG1263	PTS System
VRUMOI_RS12180	COG1609	Transcriptional regulator
VRUMOI_RS12190	COG0138	bifunctional purine biosynthesis protein purh
VRUMOI_RS12195	COG0151	Belongs to the GarS family
VRUMOI_RS12220	COG1573	uracil-dna glycosylase
VRUMOI_RS12235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VRUMOI_RS12255	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VRUMOI_RS12270	COG0085	RNA polymerase activity
VRUMOI_RS12280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VRUMOI_RS12285	COG0081	regulation of translation
VRUMOI_RS12295	COG0250	Participates in transcription elongation, termination and antitermination
VRUMOI_RS12300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VRUMOI_RS12305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VRUMOI_RS12330	COG1072	(Pantothenic acid kinase))
VRUMOI_RS12340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VRUMOI_RS12350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VRUMOI_RS12375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VRUMOI_RS12390	COG0408	coproporphyrinogen oxidase activity
VRUMOI_RS12395	COG0009	L-threonylcarbamoyladenylate synthase
VRUMOI_RS12400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VRUMOI_RS12405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VRUMOI_RS12410	COG0551	DNA topoisomerase type I activity
VRUMOI_RS12415	COG2922	Belongs to the Smg family
VRUMOI_RS12420	COG0758	DNA mediated transformation
VRUMOI_RS12430	COG0242	peptide deformylase activity
VRUMOI_RS12435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VRUMOI_RS12440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VRUMOI_RS12440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VRUMOI_RS12445	COG0569	domain protein
VRUMOI_RS12450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VRUMOI_RS12455	COG1272	protein, Hemolysin III
VRUMOI_RS12465	COG3084	Protein conserved in bacteria
VRUMOI_RS12475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VRUMOI_RS12480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VRUMOI_RS12485	COG0204	Acyl-transferase
VRUMOI_RS12500	COG3978	acetolactate synthase activity
VRUMOI_RS12515	COG0129	dihydroxy-acid dehydratase activity
VRUMOI_RS12530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VRUMOI_RS12535	COG1263	PTS System
VRUMOI_RS12535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VRUMOI_RS12540	COG0583	DNA-binding transcription factor activity
VRUMOI_RS12545	COG2814	Major facilitator Superfamily
VRUMOI_RS12555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VRUMOI_RS12560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VRUMOI_RS12565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VRUMOI_RS12575	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VRUMOI_RS12580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VRUMOI_RS12590	COG0356	it plays a direct role in the translocation of protons across the membrane
VRUMOI_RS12600	COG1475	DNA binding
VRUMOI_RS12605	COG1192	Involved in chromosome partitioning
VRUMOI_RS12610	COG0357	Ribosomal RNA small subunit methyltransferase G
VRUMOI_RS12615	COG0445	tRNA wobble uridine modification
VRUMOI_RS12650	COG2084	Dehydrogenase
VRUMOI_RS12660	COG3119	arylsulfatase activity
VRUMOI_RS12665	COG0714	Associated with various cellular activities
VRUMOI_RS12685	COG2304	oxidoreductase activity
VRUMOI_RS12695	COG0583	DNA-binding transcription factor activity
VRUMOI_RS12715	COG0534	Mate efflux family protein
VRUMOI_RS12725	COG1357	PFAM Pentapeptide repeats (8 copies)
VRUMOI_RS12730	COG0154	amidase activity
VRUMOI_RS12745	COG0786	glutamate:sodium symporter activity
VRUMOI_RS12755	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VRUMOI_RS12760	COG4948	Mandelate Racemase Muconate Lactonizing
VRUMOI_RS12765	COG2852	Protein conserved in bacteria
VRUMOI_RS12795	COG4175	Glycine betaine
VRUMOI_RS12815	COG1012	belongs to the aldehyde dehydrogenase family
VRUMOI_RS12825	COG4771	TonB-dependent receptor
VRUMOI_RS12830	COG0583	DNA-binding transcription factor activity
VRUMOI_RS12835	COG4604	ABC transporter, ATP-binding protein
VRUMOI_RS12840	COG4605	iron ion homeostasis
VRUMOI_RS12845	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VRUMOI_RS12855	COG1846	Transcriptional regulator
VRUMOI_RS12860	COG1764	response to oxidative stress
VRUMOI_RS12865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VRUMOI_RS12870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VRUMOI_RS12875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VRUMOI_RS12885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VRUMOI_RS12890	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VRUMOI_RS12905	COG1902	pentaerythritol trinitrate reductase activity
VRUMOI_RS12905	COG0446	pyridine nucleotide-disulphide oxidoreductase
VRUMOI_RS12920	COG1464	Belongs to the NlpA lipoprotein family
VRUMOI_RS12940	COG1011	Hydrolase
VRUMOI_RS12965	COG2113	Glycine betaine
VRUMOI_RS12970	COG2113	Glycine betaine
VRUMOI_RS12975	COG4176	ABC-type proline glycine betaine transport system permease component
VRUMOI_RS12990	COG0318	PFAM AMP-dependent synthetase and ligase
VRUMOI_RS13000	COG4221	oxidoreductase activity
VRUMOI_RS13015	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VRUMOI_RS13020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VRUMOI_RS13030	COG0418	dihydroorotase activity
VRUMOI_RS13035	COG0633	Ferredoxin
VRUMOI_RS13035	COG3217	Mosc domain protein beta barrel domain protein
VRUMOI_RS13040	COG0561	phosphatase activity
VRUMOI_RS13050	COG0697	spore germination
VRUMOI_RS13060	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VRUMOI_RS13065	COG0513	Belongs to the DEAD box helicase family
VRUMOI_RS13080	COG1129	ABC transporter
VRUMOI_RS13085	COG1172	Belongs to the binding-protein-dependent transport system permease family
VRUMOI_RS13095	COG0667	Aldo Keto reductase
VRUMOI_RS13100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VRUMOI_RS13110	COG1070	Carbohydrate kinase
VRUMOI_RS13115	COG1454	alcohol dehydrogenase
VRUMOI_RS13130	COG1414	Transcriptional regulator
VRUMOI_RS13135	COG1414	Transcriptional regulator
VRUMOI_RS13160	COG0583	DNA-binding transcription factor activity
VRUMOI_RS13165	COG3384	dioxygenase
VRUMOI_RS13170	COG2259	Doxx family
VRUMOI_RS13175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VRUMOI_RS13190	COG3335	DDE superfamily endonuclease
VRUMOI_RS13215	COG0583	DNA-binding transcription factor activity
VRUMOI_RS13220	COG3335	DDE superfamily endonuclease
VRUMOI_RS13225	COG0583	DNA-binding transcription factor activity
VRUMOI_RS13230	COG0730	response to heat
VRUMOI_RS13235	COG2200	EAL domain
VRUMOI_RS13255	COG0583	DNA-binding transcription factor activity
VRUMOI_RS13270	COG3706	GGDEF domain
VRUMOI_RS13270	COG4251	negative regulation of phosphorylation
VRUMOI_RS13270	COG5001	Diguanylate cyclase
VRUMOI_RS13270	COG2203	Gaf domain
VRUMOI_RS13275	COG1902	pentaerythritol trinitrate reductase activity
VRUMOI_RS13280	COG3722	fumarate hydratase activity
VRUMOI_RS13290	COG2213	PTS system mannitol-specific
VRUMOI_RS13290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VRUMOI_RS13295	COG1741	Belongs to the pirin family
VRUMOI_RS13310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VRUMOI_RS13315	COG1069	ribulokinase activity
VRUMOI_RS13325	COG2160	L-arabinose isomerase activity
VRUMOI_RS13345	COG1335	isochorismatase
VRUMOI_RS13370	COG2017	converts alpha-aldose to the beta-anomer
VRUMOI_RS13375	COG3940	Belongs to the glycosyl hydrolase 43 family
VRUMOI_RS13380	COG2211	Major facilitator Superfamily
VRUMOI_RS13385	COG3842	ATPase activity
VRUMOI_RS13390	COG0395	ABC-type sugar transport system, permease component
VRUMOI_RS13395	COG1175	transmembrane transport
VRUMOI_RS13405	COG2115	Belongs to the xylose isomerase family
VRUMOI_RS13410	COG2814	Major facilitator Superfamily
VRUMOI_RS13410	COG0477	Major facilitator Superfamily
VRUMOI_RS13415	COG1472	Belongs to the glycosyl hydrolase 3 family
VRUMOI_RS13425	COG1070	Carbohydrate kinase
VRUMOI_RS13430	COG2207	Transcriptional regulator
VRUMOI_RS13430	COG1609	Transcriptional regulator
VRUMOI_RS13440	COG1242	4 iron, 4 sulfur cluster binding
VRUMOI_RS13460	COG0243	molybdopterin cofactor binding
VRUMOI_RS13475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VRUMOI_RS13475	COG1116	anion transmembrane transporter activity
VRUMOI_RS13480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VRUMOI_RS13485	COG1116	anion transmembrane transporter activity
VRUMOI_RS13490	COG2146	nitrite reductase [NAD(P)H] activity
VRUMOI_RS13490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VRUMOI_RS13500	COG2814	Major facilitator Superfamily
VRUMOI_RS13505	COG0671	phosphoesterase, PA-phosphatase related
VRUMOI_RS13525	COG2304	oxidoreductase activity
VRUMOI_RS13545	COG0714	Associated with various cellular activities
VRUMOI_RS13555	COG3530	Putative quorum-sensing-regulated virulence factor
VRUMOI_RS13570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VRUMOI_RS13575	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VRUMOI_RS13585	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VRUMOI_RS13630	COG0534	Mate efflux family protein
VRUMOI_RS13640	COG2721	sulfolactate sulfo-lyase activity
VRUMOI_RS13655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VRUMOI_RS13670	COG0246	Mannitol dehydrogenase
VRUMOI_RS13675	COG0246	Mannitol dehydrogenase
VRUMOI_RS13680	COG0246	Mannitol dehydrogenase
VRUMOI_RS13845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VRUMOI_RS13855	COG2897	thiosulfate sulfurtransferase activity
VRUMOI_RS13925	COG3829	transcription factor binding
VRUMOI_RS13950	COG1803	Methylglyoxal synthase
VRUMOI_RS13955	COG0456	acetyltransferase
VRUMOI_RS13960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VRUMOI_RS13965	COG0662	Cupin 2, conserved barrel domain protein
VRUMOI_RS13970	COG0527	aspartate kinase activity
VRUMOI_RS13995	COG1999	signal sequence binding
VRUMOI_RS14015	COG0531	amino acid
VRUMOI_RS14030	COG3123	guanosine phosphorylase activity
VRUMOI_RS14040	COG3335	DDE superfamily endonuclease
VRUMOI_RS14045	COG1335	isochorismatase
VRUMOI_RS14055	COG0189	ligase activity
VRUMOI_RS14060	COG4067	protein conserved in archaea
VRUMOI_RS14060	COG0189	ligase activity
VRUMOI_RS14075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
VRUMOI_RS14080	COG4208	sulfate ABC transporter
VRUMOI_RS14085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VRUMOI_RS14090	COG4160	amino acid transport
VRUMOI_RS14095	COG4215	(ABC) transporter
VRUMOI_RS14100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VRUMOI_RS14105	COG1126	abc transporter atp-binding protein
VRUMOI_RS14130	COG1609	Transcriptional regulator
VRUMOI_RS14135	COG2252	PERMEase
VRUMOI_RS14180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VRUMOI_RS14205	COG0243	molybdopterin cofactor binding
VRUMOI_RS14215	COG2814	Major facilitator Superfamily
VRUMOI_RS14220	COG2814	Major facilitator Superfamily
VRUMOI_RS14225	COG0628	permease
VRUMOI_RS14245	COG0582	viral genome integration into host DNA
VRUMOI_RS14280	COG1904	glucuronate isomerase
VRUMOI_RS14290	COG0800	Aldolase
VRUMOI_RS14295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VRUMOI_RS14310	COG1917	Cupin 2, conserved barrel domain protein
VRUMOI_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
VRUMOI_RS14325	COG0517	IMP dehydrogenase activity
VRUMOI_RS14330	COG2176	DNA-directed DNA polymerase activity
VRUMOI_RS14355	COG2801	Transposase and inactivated derivatives
VRUMOI_RS14405	COG1132	(ABC) transporter
VRUMOI_RS14410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VRUMOI_RS14420	COG3335	DDE superfamily endonuclease
VRUMOI_RS14435	COG0823	Involved in the tonB-independent uptake of proteins
VRUMOI_RS14445	COG1904	glucuronate isomerase
VRUMOI_RS14455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VRUMOI_RS14465	COG0800	Aldolase
VRUMOI_RS14470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VRUMOI_RS14480	COG1917	Cupin 2, conserved barrel domain protein
VRUMOI_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
VRUMOI_RS14500	COG2176	DNA-directed DNA polymerase activity
VRUMOI_RS14505	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
VRUMOI_RS14510	COG2721	sulfolactate sulfo-lyase activity
VRUMOI_RS14525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VRUMOI_RS14540	COG0246	Mannitol dehydrogenase
VRUMOI_RS14615	COG3335	DDE superfamily endonuclease
VRUMOI_RS14690	COG4989	oxidoreductase activity
VRUMOI_RS14700	COG2814	Major facilitator Superfamily
VRUMOI_RS14705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VRUMOI_RS14715	COG2897	thiosulfate sulfurtransferase activity
VRUMOI_RS14735	COG1940	carbohydrate kinase activity
VRUMOI_RS14740	COG0004	ammonium transporteR
VRUMOI_RS14750	COG0523	cobalamin synthesis protein
VRUMOI_RS14780	COG1176	ABC-type spermidine putrescine transport system, permease component I
VRUMOI_RS14790	COG3842	ATPase activity
VRUMOI_RS14810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VRUMOI_RS14815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VRUMOI_RS14835	COG1278	Cold shock
VRUMOI_RS14855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VRUMOI_RS14865	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
VRUMOI_RS14875	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VRUMOI_RS14880	COG1609	Transcriptional regulator
VRUMOI_RS14885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VRUMOI_RS14890	COG1879	ABC-type sugar transport system periplasmic component
VRUMOI_RS14895	COG1172	Belongs to the binding-protein-dependent transport system permease family
VRUMOI_RS14900	COG1129	ABC transporter
VRUMOI_RS14905	COG1869	D-ribose catabolic process
VRUMOI_RS14910	COG0123	including yeast histone deacetylase and acetoin utilization protein
VRUMOI_RS14925	COG1451	nucleotide metabolic process
VRUMOI_RS14935	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VRUMOI_RS14945	COG4181	ATPase activity
VRUMOI_RS14950	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VRUMOI_RS14965	COG1328	CTP reductase activity
VRUMOI_RS14970	COG0602	queuosine metabolic process
VRUMOI_RS14980	COG4067	protein conserved in archaea
VRUMOI_RS14980	COG0189	ligase activity
VRUMOI_RS14985	COG0346	lactoylglutathione lyase activity
VRUMOI_RS14990	COG1492	cobalamin metabolic process
VRUMOI_RS14995	COG2005	Transcriptional regulator
VRUMOI_RS14995	COG3585	molybdate ion transport
VRUMOI_RS15000	COG0725	ABC transporter, periplasmic molybdate-binding protein
VRUMOI_RS15005	COG4149	molybdate abc transporter
VRUMOI_RS15010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VRUMOI_RS15015	COG3769	mannosylglycerate metabolic process
VRUMOI_RS15020	COG1215	transferase activity, transferring glycosyl groups
VRUMOI_RS15030	COG0521	Mo-molybdopterin cofactor biosynthetic process
VRUMOI_RS15035	COG3547	Transposase (IS116 IS110 IS902 family)
VRUMOI_RS15105	COG1794	racemase activity, acting on amino acids and derivatives
VRUMOI_RS15130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VRUMOI_RS15135	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VRUMOI_RS15145	COG0745	RESPONSE REGULATOR receiver
VRUMOI_RS15155	COG3140	Belongs to the UPF0181 family
VRUMOI_RS15160	COG0583	DNA-binding transcription factor activity
VRUMOI_RS15165	COG3085	chromosome segregation
VRUMOI_RS15185	COG3278	Belongs to the heme-copper respiratory oxidase family
VRUMOI_RS15200	COG2010	Cytochrome c
VRUMOI_RS15210	COG2217	Heavy metal translocating P-type atpase
VRUMOI_RS15225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VRUMOI_RS15235	COG0589	response to stress
VRUMOI_RS15240	COG0037	tRNA processing
VRUMOI_RS15250	COG2992	FlgJ-related protein
VRUMOI_RS15260	COG3842	ATPase activity
VRUMOI_RS15265	COG1176	ABC-type spermidine putrescine transport system, permease component I
VRUMOI_RS15270	COG1177	transmembrane transport
VRUMOI_RS15280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VRUMOI_RS15300	COG1940	carbohydrate kinase activity
VRUMOI_RS15305	COG0791	NLP P60 protein
VRUMOI_RS15320	COG0534	Mate efflux family protein
VRUMOI_RS15325	COG1793	dna ligase
VRUMOI_RS15330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VRUMOI_RS15340	COG4176	ABC-type proline glycine betaine transport system permease component
VRUMOI_RS15355	COG0437	4 iron, 4 sulfur cluster binding
VRUMOI_RS15360	COG3383	formate dehydrogenase (NAD+) activity
VRUMOI_RS15390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VRUMOI_RS15400	COG4662	Binding-protein-dependent transport system inner membrane component
VRUMOI_RS15405	COG3842	ATPase activity
VRUMOI_RS15410	COG0746	molybdenum cofactor guanylyltransferase activity
VRUMOI_RS15415	COG0303	'Molybdopterin
VRUMOI_RS15430	COG0583	DNA-binding transcription factor activity
VRUMOI_RS15435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VRUMOI_RS15445	COG1301	dicarboxylic acid transport
VRUMOI_RS15455	COG0351	phosphomethylpyrimidine kinase
VRUMOI_RS15470	COG0069	glutamate synthase activity
VRUMOI_RS15485	COG0625	glutathione transferase activity
VRUMOI_RS15495	COG3122	Protein conserved in bacteria
VRUMOI_RS15510	COG0513	Belongs to the DEAD box helicase family
VRUMOI_RS15525	COG3040	lipid binding
VRUMOI_RS15535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VRUMOI_RS15540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VRUMOI_RS15545	COG0583	DNA-binding transcription factor activity
VRUMOI_RS15560	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VRUMOI_RS15565	COG4139	cobalamin transport
VRUMOI_RS15570	COG2988	succinylglutamate desuccinylase activity
VRUMOI_RS15575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VRUMOI_RS15575	COG1648	precorrin-2 dehydrogenase activity
VRUMOI_RS15580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VRUMOI_RS15585	COG4597	amino acid ABC transporter
VRUMOI_RS15590	COG0765	amino acid transport
VRUMOI_RS15595	COG1126	abc transporter atp-binding protein
VRUMOI_RS15610	COG0670	Belongs to the BI1 family
VRUMOI_RS15615	COG2920	part of a sulfur-relay system
VRUMOI_RS15620	COG1254	Belongs to the acylphosphatase family
VRUMOI_RS15625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VRUMOI_RS15635	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VRUMOI_RS15650	COG1280	lysine exporter protein (LysE YggA)
VRUMOI_RS15655	COG1823	symporter activity
VRUMOI_RS15675	COG0443	Heat shock 70 kDa protein
VRUMOI_RS15680	COG4221	oxidoreductase activity
VRUMOI_RS15685	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VRUMOI_RS15685	COG3264	Mechanosensitive ion channel
VRUMOI_RS15705	COG0419	ATPase involved in DNA repair
VRUMOI_RS15710	COG0420	3'-5' exonuclease activity
VRUMOI_RS15715	COG1462	curli production assembly transport component CsgG
VRUMOI_RS15750	COG1063	alcohol dehydrogenase
VRUMOI_RS15755	COG0156	8-amino-7-oxononanoate synthase activity
VRUMOI_RS15765	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VRUMOI_RS15795	COG2188	Transcriptional regulator
VRUMOI_RS15805	COG1765	OsmC-like protein
VRUMOI_RS15855	COG1765	OsmC-like protein
VRUMOI_RS15860	COG3304	Inner membrane component domain
VRUMOI_RS15865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VRUMOI_RS15870	COG0569	domain protein
VRUMOI_RS15875	COG0668	transmembrane transport
VRUMOI_RS15880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VRUMOI_RS15885	COG1012	belongs to the aldehyde dehydrogenase family
VRUMOI_RS15890	COG1522	sequence-specific DNA binding
VRUMOI_RS15895	COG0006	proline dipeptidase activity
VRUMOI_RS15905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VRUMOI_RS15910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VRUMOI_RS15915	COG1120	ATPase activity
VRUMOI_RS15930	COG4264	IucA IucC family
VRUMOI_RS15940	COG3135	benzoate transporter
VRUMOI_RS15945	COG0583	DNA-binding transcription factor activity
VRUMOI_RS15975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VRUMOI_RS15985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VRUMOI_RS15990	COG0574	Belongs to the PEP-utilizing enzyme family
VRUMOI_RS15990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VRUMOI_RS16000	COG1640	4-alpha-glucanotransferase
VRUMOI_RS16015	COG0405	Gamma-glutamyltransferase
VRUMOI_RS16020	COG0583	DNA-binding transcription factor activity
VRUMOI_RS16025	COG1902	pentaerythritol trinitrate reductase activity
VRUMOI_RS16030	COG3833	ABC-type maltose transport systems, permease component
VRUMOI_RS16035	COG1175	transmembrane transport
VRUMOI_RS16045	COG3842	ATPase activity
VRUMOI_RS16050	COG3181	Tripartite tricarboxylate transporter family receptor
VRUMOI_RS16070	COG4565	transcriptional regulatory protein
VRUMOI_RS16090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VRUMOI_RS16120	COG0366	Alpha amylase catalytic
VRUMOI_RS16150	COG0513	Belongs to the DEAD box helicase family
VRUMOI_RS16155	COG3314	Sporulation integral membrane protein YlbJ
VRUMOI_RS16160	COG3111	PFAM Bacterial OB fold (BOF) protein
VRUMOI_RS16165	COG2205	protein histidine kinase activity
VRUMOI_RS16165	COG2770	Histidine kinase
VRUMOI_RS16170	COG0745	RESPONSE REGULATOR receiver
VRUMOI_RS16180	COG1422	Protein of unknown function (DUF1090)
VRUMOI_RS16185	COG1346	cytolysis
VRUMOI_RS16190	COG1380	Effector of murein hydrolase LrgA
VRUMOI_RS16195	COG0583	DNA-binding transcription factor activity
VRUMOI_RS16205	COG0516	GMP reductase activity
VRUMOI_RS16225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VRUMOI_RS16235	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VRUMOI_RS16240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VRUMOI_RS16245	COG0247	lactate metabolic process
VRUMOI_RS16245	COG0277	FAD linked oxidase domain protein
VRUMOI_RS16275	COG1879	ABC-type sugar transport system periplasmic component
VRUMOI_RS16280	COG1129	ABC transporter
VRUMOI_RS16285	COG1172	Belongs to the binding-protein-dependent transport system permease family
VRUMOI_RS16290	COG1172	Belongs to the binding-protein-dependent transport system permease family
VRUMOI_RS16295	COG0653	protein targeting
VRUMOI_RS16310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VRUMOI_RS16320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VRUMOI_RS16325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VRUMOI_RS16350	COG0210	DNA helicase
VRUMOI_RS16355	COG1289	transmembrane transporter activity
VRUMOI_RS16360	COG2184	nucleotidyltransferase activity
VRUMOI_RS16365	COG1984	allophanate hydrolase subunit 2
VRUMOI_RS16370	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VRUMOI_RS16400	COG0110	maltose O-acetyltransferase activity
VRUMOI_RS16405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VRUMOI_RS16410	COG0516	GMP reductase activity
VRUMOI_RS16410	COG0517	IMP dehydrogenase activity
VRUMOI_RS16445	COG0402	S-adenosylhomocysteine deaminase activity
VRUMOI_RS16455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VRUMOI_RS16465	COG0814	amino acid
VRUMOI_RS16470	COG1309	transcriptional regulator
VRUMOI_RS16475	COG2084	Dehydrogenase
VRUMOI_RS16480	COG3622	Belongs to the hyi family
VRUMOI_RS16485	COG3960	tartronate-semialdehyde synthase activity
VRUMOI_RS16490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VRUMOI_RS16500	COG2186	Transcriptional regulator
VRUMOI_RS16510	COG3328	transposase activity
VRUMOI_RS16515	COG1621	beta-fructofuranosidase activity
VRUMOI_RS16520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VRUMOI_RS16525	COG1263	PTS System
VRUMOI_RS16525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VRUMOI_RS16535	COG2200	EAL domain
VRUMOI_RS16535	COG2771	luxR family
VRUMOI_RS16555	COG1263	PTS System
VRUMOI_RS16555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VRUMOI_RS16560	COG0366	Alpha amylase catalytic
VRUMOI_RS16565	COG1609	Transcriptional regulator
VRUMOI_RS16570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VRUMOI_RS16575	COG1054	Belongs to the UPF0176 family
VRUMOI_RS16585	COG2988	succinylglutamate desuccinylase activity
VRUMOI_RS16590	COG3724	N-succinylarginine dihydrolase activity
VRUMOI_RS16595	COG1012	belongs to the aldehyde dehydrogenase family
VRUMOI_RS16600	COG3138	arginine N-succinyltransferase
VRUMOI_RS16620	COG4993	Dehydrogenase
VRUMOI_RS16625	COG3706	GGDEF domain
VRUMOI_RS16645	COG1388	LysM domain
VRUMOI_RS16645	COG1705	Flagellar rod assembly protein muramidase FlgJ
VRUMOI_RS16655	COG3501	Rhs element vgr protein
VRUMOI_RS16665	COG1879	ABC-type sugar transport system periplasmic component
VRUMOI_RS16670	COG1129	ABC transporter
VRUMOI_RS16675	COG1172	Belongs to the binding-protein-dependent transport system permease family
VRUMOI_RS16680	COG0673	inositol 2-dehydrogenase activity
VRUMOI_RS16685	COG1538	Outer membrane efflux protein
VRUMOI_RS16690	COG1136	(ABC) transporter
VRUMOI_RS16690	COG0577	efflux transmembrane transporter activity
VRUMOI_RS16695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VRUMOI_RS16735	COG2731	YhcH YjgK YiaL family protein
VRUMOI_RS16740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VRUMOI_RS16750	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VRUMOI_RS16755	COG1737	Transcriptional regulator
VRUMOI_RS16760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VRUMOI_RS16765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VRUMOI_RS16770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VRUMOI_RS16775	COG1085	galactose-1-phosphate uridylyltransferase
VRUMOI_RS16780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VRUMOI_RS16785	COG0737	Belongs to the 5'-nucleotidase family
VRUMOI_RS16800	COG5413	integral membrane protein
VRUMOI_RS16815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VRUMOI_RS16820	COG0789	Transcriptional regulator
VRUMOI_RS16840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VRUMOI_RS16850	COG4681	YaeQ
VRUMOI_RS16875	COG2354	Protein conserved in bacteria
VRUMOI_RS16880	COG1757	Na H antiporter
VRUMOI_RS16890	COG2199	diguanylate cyclase activity
VRUMOI_RS16895	COG3302	dmso reductase anchor subunit
VRUMOI_RS16900	COG0437	4 iron, 4 sulfur cluster binding
VRUMOI_RS16905	COG0243	molybdopterin cofactor binding
VRUMOI_RS16915	COG0437	4 iron, 4 sulfur cluster binding
VRUMOI_RS16920	COG2885	chlorophyll binding
VRUMOI_RS16950	COG1067	ATP-dependent peptidase activity
VRUMOI_RS16980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VRUMOI_RS17015	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
VRUMOI_RS17020	COG0804	urea catabolic process
VRUMOI_RS17030	COG0831	urea catabolic process
VRUMOI_RS17035	COG0829	nickel cation binding
VRUMOI_RS17045	COG0300	oxidoreductase activity
VRUMOI_RS17060	COG0668	transmembrane transport
VRUMOI_RS17095	COG2165	general secretion pathway protein
VRUMOI_RS17105	COG2771	luxR family
VRUMOI_RS17105	COG2200	EAL domain
VRUMOI_RS17115	COG2200	EAL domain
VRUMOI_RS17120	COG0583	DNA-binding transcription factor activity
VRUMOI_RS17125	COG3257	ureidoglycine aminohydrolase activity
VRUMOI_RS17130	COG0642	Histidine kinase
VRUMOI_RS17140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VRUMOI_RS17145	COG2194	sulfuric ester hydrolase activity
VRUMOI_RS17155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VRUMOI_RS17160	COG0573	inorganic phosphate transmembrane transporter activity
VRUMOI_RS17165	COG0581	inorganic phosphate transmembrane transporter activity
VRUMOI_RS17170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VRUMOI_RS17175	COG2199	diguanylate cyclase activity
VRUMOI_RS17180	COG3328	transposase activity
VRUMOI_RS17190	COG0307	riboflavin synthase, alpha
VRUMOI_RS17195	COG2197	response regulator
VRUMOI_RS17200	COG3850	Histidine kinase
VRUMOI_RS17225	COG3005	denitrification pathway
VRUMOI_RS17240	COG0765	amino acid transport
VRUMOI_RS17245	COG0765	amino acid transport
VRUMOI_RS17250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VRUMOI_RS17255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VRUMOI_RS17270	COG4221	oxidoreductase activity
VRUMOI_RS17280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VRUMOI_RS17285	COG2146	nitrite reductase [NAD(P)H] activity
VRUMOI_RS17305	COG1648	precorrin-2 dehydrogenase activity
VRUMOI_RS17305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VRUMOI_RS17315	COG2827	Endonuclease containing a URI domain
VRUMOI_RS17320	COG3132	Protein of unknown function, DUF480
VRUMOI_RS17335	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VRUMOI_RS17340	COG0513	Belongs to the DEAD box helicase family
VRUMOI_RS17345	COG1609	Transcriptional regulator
VRUMOI_RS17350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VRUMOI_RS17350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VRUMOI_RS17355	COG1105	Belongs to the carbohydrate kinase PfkB family
VRUMOI_RS17360	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VRUMOI_RS17360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VRUMOI_RS17360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VRUMOI_RS17370	COG1280	lysine exporter protein (LysE YggA)
VRUMOI_RS17375	COG0564	pseudouridine synthase activity
VRUMOI_RS17385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VRUMOI_RS17390	COG1115	amino acid carrier protein
VRUMOI_RS17400	COG0509	glycine decarboxylation via glycine cleavage system
VRUMOI_RS17405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VRUMOI_RS17405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VRUMOI_RS17420	COG2824	Alkylphosphonate utilization operon protein PhnA
VRUMOI_RS17425	COG0583	DNA-binding transcription factor activity
VRUMOI_RS17430	COG4221	oxidoreductase activity
VRUMOI_RS17435	COG1263	PTS System
VRUMOI_RS17435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VRUMOI_RS17460	COG0583	DNA-binding transcription factor activity
VRUMOI_RS17465	COG2814	Major facilitator Superfamily
VRUMOI_RS17495	COG0109	protoheme IX farnesyltransferase activity
VRUMOI_RS17520	COG1845	cytochrome c oxidase, subunit III
VRUMOI_RS17525	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VRUMOI_RS17530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VRUMOI_RS17535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VRUMOI_RS17535	COG1565	acr, cog1565
VRUMOI_RS17540	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VRUMOI_RS17545	COG0747	negative chemotaxis
VRUMOI_RS17555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VRUMOI_RS17560	COG4172	Belongs to the ABC transporter superfamily
VRUMOI_RS17585	COG0625	glutathione transferase activity
VRUMOI_RS17595	COG3501	Rhs element vgr protein
VRUMOI_RS17610	COG0697	spore germination
VRUMOI_RS17620	COG1349	DNA-binding transcription factor activity
VRUMOI_RS17625	COG1597	lipid kinase activity
VRUMOI_RS17625	COG1803	Methylglyoxal synthase
VRUMOI_RS17635	COG3842	ATPase activity
VRUMOI_RS17640	COG1176	ABC-type spermidine putrescine transport system, permease component I
VRUMOI_RS17645	COG1177	transmembrane transport
VRUMOI_RS17650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VRUMOI_RS17660	COG1280	lysine exporter protein (LysE YggA)
VRUMOI_RS17670	COG2207	Transcriptional regulator
VRUMOI_RS17680	COG2199	diguanylate cyclase activity
VRUMOI_RS17690	COG1278	Cold shock
VRUMOI_RS17695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VRUMOI_RS17715	COG0259	pyridoxamine-phosphate oxidase activity
VRUMOI_RS17720	COG1444	tRNA N-acetyltransferase activity
VRUMOI_RS17815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VRUMOI_RS17935	COG0616	signal peptide processing
VRUMOI_RS18080	COG0753	catalase activity
VRUMOI_RS18120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VRUMOI_RS18145	COG0789	Transcriptional regulator
VRUMOI_RS18150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VRUMOI_RS18155	COG0589	response to stress
VRUMOI_RS18160	COG0659	secondary active sulfate transmembrane transporter activity
VRUMOI_RS18170	COG0789	Transcriptional regulator
VRUMOI_RS18215	COG4974	Belongs to the 'phage' integrase family
VRUMOI_RS18375	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VRUMOI_RS18450	COG0633	Ferredoxin
VRUMOI_RS18500	COG0714	Associated with various cellular activities
VRUMOI_RS18560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VRUMOI_RS18650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VRUMOI_RS18735	COG1192	Involved in chromosome partitioning
VRUMOI_RS18755	COG2204	response regulator
VRUMOI_RS18785	COG0443	Heat shock 70 kDa protein
VRUMOI_RS18790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VRUMOI_RS18800	COG3773	Cell wall hydrolase
VRUMOI_RS18800	COG3409	Peptidoglycan-binding domain 1 protein
VRUMOI_RS18820	COG2026	Addiction module toxin, RelE StbE family
VRUMOI_RS18825	COG3344	reverse transcriptase
VRUMOI_RS18890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VRUMOI_RS18925	COG3547	Transposase (IS116 IS110 IS902 family)
VRUMOI_RS18930	COG3344	reverse transcriptase
VRUMOI_RS18935	COG4644	lycopene metabolic process
VRUMOI_RS18965	COG1461	Dihydroxyacetone kinase
VRUMOI_RS18970	COG2376	Dihydroxyacetone kinase
VRUMOI_RS19005	COG3069	C4-dicarboxylate transmembrane transporter activity
VRUMOI_RS19010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VRUMOI_RS19020	COG1737	Transcriptional regulator
VRUMOI_RS19030	COG1609	Transcriptional regulator
VRUMOI_RS19035	COG2610	gluconate transmembrane transporter activity
VRUMOI_RS19045	COG2610	gluconate transmembrane transporter activity
VRUMOI_RS19050	COG3265	gluconokinase activity
VRUMOI_RS19055	COG0129	dihydroxy-acid dehydratase activity
VRUMOI_RS19060	COG0800	Aldolase
VRUMOI_RS19080	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VRUMOI_RS19095	COG3177	Filamentation induced by cAMP protein fic
VRUMOI_RS19155	COG0675	Transposase, IS605 OrfB family
VRUMOI_RS19170	COG3676	manually curated
VRUMOI_RS19190	COG1192	Involved in chromosome partitioning