locus-tag	class	description
VSVS12_RS00010	COG0534	Mate efflux family protein
VSVS12_RS00020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VSVS12_RS00025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VSVS12_RS00030	COG2937	Belongs to the GPAT DAPAT family
VSVS12_RS00035	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VSVS12_RS00040	COG3161	chorismate lyase activity
VSVS12_RS00045	COG1580	Controls the rotational direction of flagella during chemotaxis
VSVS12_RS00050	COG0705	Rhomboid family
VSVS12_RS00055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSVS12_RS00065	COG2177	Part of the ABC transporter FtsEX involved in
VSVS12_RS00070	COG2884	Cell division ATP-binding protein ftsE
VSVS12_RS00075	COG0552	protein localization to endoplasmic reticulum
VSVS12_RS00080	COG0742	ribosomal rna small subunit methyltransferase
VSVS12_RS00090	COG2095	MarC family integral membrane protein
VSVS12_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSVS12_RS00145	COG0640	Transcriptional regulator
VSVS12_RS00150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VSVS12_RS00155	COG1280	lysine exporter protein (LysE YggA)
VSVS12_RS00160	COG2267	carboxylic ester hydrolase activity
VSVS12_RS00165	COG0561	phosphatase activity
VSVS12_RS00175	COG3148	PFAM DTW domain containing protein
VSVS12_RS00180	COG1011	Hydrolase
VSVS12_RS00185	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VSVS12_RS00195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VSVS12_RS00200	COG0019	diaminopimelate decarboxylase activity
VSVS12_RS00210	COG1965	Belongs to the frataxin family
VSVS12_RS00215	COG3072	Adenylate cyclase
VSVS12_RS00220	COG0181	hydroxymethylbilane synthase activity
VSVS12_RS00225	COG1587	Uroporphyrinogen-III synthase
VSVS12_RS00230	COG2959	enzyme of heme biosynthesis
VSVS12_RS00235	COG3071	HemY protein
VSVS12_RS00320	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VSVS12_RS00335	COG3118	belongs to the thioredoxin family
VSVS12_RS00345	COG0248	Ppx GppA phosphatase
VSVS12_RS00350	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VSVS12_RS00360	COG0514	ATP-dependent DNA helicase (RecQ)
VSVS12_RS00365	COG2962	Rard protein
VSVS12_RS00375	COG1280	lysine exporter protein (LysE YggA)
VSVS12_RS00380	COG0210	DNA helicase
VSVS12_RS00390	COG3220	belongs to the UPF0276 family
VSVS12_RS00405	COG0339	signal peptide processing
VSVS12_RS00410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VSVS12_RS00415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSVS12_RS00430	COG1301	dicarboxylic acid transport
VSVS12_RS00435	COG0626	cystathionine gamma-synthase activity
VSVS12_RS00440	COG0251	oxidation-reduction process
VSVS12_RS00445	COG0840	transmembrane signaling receptor activity
VSVS12_RS00490	COG2194	sulfuric ester hydrolase activity
VSVS12_RS00495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VSVS12_RS00500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSVS12_RS00505	COG0601	transmembrane transport
VSVS12_RS00510	COG0747	negative chemotaxis
VSVS12_RS00555	COG1309	transcriptional regulator
VSVS12_RS00560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_RS00565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_RS00570	COG2960	long-chain fatty acid transporting porin activity
VSVS12_RS00575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VSVS12_RS00580	COG0583	DNA-binding transcription factor activity
VSVS12_RS00615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VSVS12_RS00620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VSVS12_RS00620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VSVS12_RS00630	COG0084	hydrolase, TatD family'
VSVS12_RS00635	COG0805	protein transport
VSVS12_RS00640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VSVS12_RS00645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VSVS12_RS00650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VSVS12_RS00660	COG2226	methyltransferase
VSVS12_RS00665	COG1322	Protein conserved in bacteria
VSVS12_RS00675	COG0800	Aldolase
VSVS12_RS00680	COG2610	gluconate transmembrane transporter activity
VSVS12_RS00685	COG3265	gluconokinase activity
VSVS12_RS00690	COG0129	dihydroxy-acid dehydratase activity
VSVS12_RS00695	COG1609	Transcriptional regulator
VSVS12_RS00710	COG2856	Zn peptidase
VSVS12_RS00745	COG2081	HI0933 family
VSVS12_RS00755	COG1528	Iron-storage protein
VSVS12_RS00760	COG0589	response to stress
VSVS12_RS00770	COG0742	ribosomal rna small subunit methyltransferase
VSVS12_RS00775	COG5001	Diguanylate cyclase
VSVS12_RS00775	COG5002	protein histidine kinase activity
VSVS12_RS00780	COG1522	sequence-specific DNA binding
VSVS12_RS00800	COG0006	proline dipeptidase activity
VSVS12_RS00800	COG0006	proline dipeptidase activity
VSVS12_RS00805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VSVS12_RS00810	COG2022	thiamine diphosphate biosynthetic process
VSVS12_RS00815	COG2104	thiamine diphosphate biosynthetic process
VSVS12_RS00820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VSVS12_RS00825	COG0352	thiamine-phosphate diphosphorylase activity
VSVS12_RS00905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VSVS12_RS00910	COG1739	Uncharacterized protein family UPF0029
VSVS12_RS00920	COG0183	Belongs to the thiolase family
VSVS12_RS00925	COG0583	DNA-binding transcription factor activity
VSVS12_RS00930	COG2814	Major facilitator Superfamily
VSVS12_RS00940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VSVS12_RS00950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VSVS12_RS00955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VSVS12_RS00960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VSVS12_RS00965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VSVS12_RS00980	COG3312	ion transport
VSVS12_RS00985	COG1475	DNA binding
VSVS12_RS00990	COG1192	Involved in chromosome partitioning
VSVS12_RS00995	COG0357	Ribosomal RNA small subunit methyltransferase G
VSVS12_RS01000	COG0445	tRNA wobble uridine modification
VSVS12_RS01005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VSVS12_RS01010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VSVS12_RS01020	COG0594	ribonuclease P activity
VSVS12_RS01030	COG1126	abc transporter atp-binding protein
VSVS12_RS01050	COG0592	DNA-directed DNA polymerase activity
VSVS12_RS01060	COG0187	DNA topoisomerase II activity
VSVS12_RS01065	COG0071	Belongs to the small heat shock protein (HSP20) family
VSVS12_RS01070	COG3977	Valine--pyruvate aminotransferase
VSVS12_RS01075	COG0751	glycine-tRNA ligase activity
VSVS12_RS01085	COG0747	negative chemotaxis
VSVS12_RS01095	COG0425	Belongs to the sulfur carrier protein TusA family
VSVS12_RS01105	COG0604	alcohol dehydrogenase
VSVS12_RS01120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VSVS12_RS01125	COG3978	acetolactate synthase activity
VSVS12_RS01135	COG0606	chelatase, subunit chli
VSVS12_RS01170	COG0606	chelatase, subunit chli
VSVS12_RS01210	COG0606	chelatase, subunit chli
VSVS12_RS01220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VSVS12_RS01225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VSVS12_RS01235	COG3084	Protein conserved in bacteria
VSVS12_RS01240	COG4326	sporulation control protein
VSVS12_RS01245	COG1272	protein, Hemolysin III
VSVS12_RS01250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VSVS12_RS01255	COG0569	domain protein
VSVS12_RS01260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VSVS12_RS01260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VSVS12_RS01270	COG0242	peptide deformylase activity
VSVS12_RS01280	COG0758	DNA mediated transformation
VSVS12_RS01300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VSVS12_RS01305	COG0009	L-threonylcarbamoyladenylate synthase
VSVS12_RS01310	COG0408	coproporphyrinogen oxidase activity
VSVS12_RS01325	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VSVS12_RS01365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VSVS12_RS01370	COG3300	MHYT domain
VSVS12_RS01370	COG5001	Diguanylate cyclase
VSVS12_RS01375	COG2204	response regulator
VSVS12_RS01380	COG3852	Histidine kinase
VSVS12_RS01385	COG0174	glutamine synthetase
VSVS12_RS01390	COG1217	gtp-binding protein TYPA
VSVS12_RS01405	COG1295	ribonuclease BN
VSVS12_RS01410	COG1490	D-aminoacyl-tRNA deacylase activity
VSVS12_RS01415	COG0456	acetyltransferase
VSVS12_RS01430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VSVS12_RS01435	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VSVS12_RS01440	COG3031	protein transport across the cell outer membrane
VSVS12_RS01450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSVS12_RS01455	COG1459	type II secretion system
VSVS12_RS01460	COG2165	general secretion pathway protein
VSVS12_RS01465	COG2165	general secretion pathway protein
VSVS12_RS01470	COG2165	general secretion pathway protein
VSVS12_RS01475	COG4795	General secretion pathway protein
VSVS12_RS01480	COG3156	type II secretion system protein K
VSVS12_RS01485	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VSVS12_RS01490	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VSVS12_RS01510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VSVS12_RS01515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VSVS12_RS01520	COG0583	DNA-binding transcription factor activity
VSVS12_RS01525	COG2183	response to ionizing radiation
VSVS12_RS01535	COG0596	Alpha beta hydrolase
VSVS12_RS01540	COG1040	competence protein
VSVS12_RS01550	COG0494	nUDIX hydrolase
VSVS12_RS01555	COG1218	3'(2'),5'-bisphosphate nucleotidase
VSVS12_RS01565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VSVS12_RS01570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VSVS12_RS01575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VSVS12_RS01580	COG1758	RNA polymerase activity
VSVS12_RS01585	COG0194	GDP metabolic process
VSVS12_RS01595	COG2252	PERMEase
VSVS12_RS01605	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VSVS12_RS01610	COG1561	YicC-like family, N-terminal region
VSVS12_RS01615	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VSVS12_RS01625	COG1560	Kdo2-lipid A biosynthetic process
VSVS12_RS01630	COG1309	transcriptional regulator
VSVS12_RS01635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VSVS12_RS01640	COG0840	transmembrane signaling receptor activity
VSVS12_RS01645	COG2003	Belongs to the UPF0758 family
VSVS12_RS01650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VSVS12_RS01665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VSVS12_RS01670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VSVS12_RS01675	COG0859	PFAM glycosyl transferase family 9
VSVS12_RS01680	COG0463	Glycosyl transferase, family 2
VSVS12_RS01685	COG0859	PFAM glycosyl transferase family 9
VSVS12_RS01690	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VSVS12_RS01695	COG3642	lipopolysaccharide core region biosynthetic process
VSVS12_RS01700	COG3083	sulfuric ester hydrolase activity
VSVS12_RS01710	COG1086	Polysaccharide biosynthesis protein
VSVS12_RS01715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VSVS12_RS01725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VSVS12_RS01730	COG0107	imidazoleglycerol-phosphate synthase activity
VSVS12_RS01735	COG1083	cytidylyl-transferase
VSVS12_RS01745	COG2089	acid synthase
VSVS12_RS01755	COG1519	Transferase
VSVS12_RS01765	COG1560	Kdo2-lipid A biosynthetic process
VSVS12_RS01770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VSVS12_RS01775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VSVS12_RS01785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VSVS12_RS01805	COG0459	protein refolding
VSVS12_RS01810	COG3706	GGDEF domain
VSVS12_RS01815	COG1494	fructose-1,6-bisphosphatase
VSVS12_RS01820	COG3074	FtsZ-dependent cytokinesis
VSVS12_RS01825	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VSVS12_RS01830	COG0460	homoserine dehydrogenase
VSVS12_RS01830	COG0527	aspartate kinase activity
VSVS12_RS01835	COG0626	cystathionine gamma-synthase activity
VSVS12_RS01840	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VSVS12_RS01845	COG0281	malic enzyme
VSVS12_RS01850	COG0254	rRNA binding
VSVS12_RS01855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VSVS12_RS01860	COG1609	Transcriptional regulator
VSVS12_RS01865	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VSVS12_RS01870	COG0250	Participates in transcription elongation, termination and antitermination
VSVS12_RS01875	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VSVS12_RS01880	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VSVS12_RS01885	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VSVS12_RS01925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VSVS12_RS01925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VSVS12_RS01960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VSVS12_RS01970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VSVS12_RS02025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSVS12_RS02045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VSVS12_RS02060	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VSVS12_RS02065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VSVS12_RS02070	COG1053	succinate dehydrogenase
VSVS12_RS02075	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VSVS12_RS02085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSVS12_RS02090	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VSVS12_RS02095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VSVS12_RS02100	COG1045	serine acetyltransferase
VSVS12_RS02110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VSVS12_RS02115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VSVS12_RS02120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VSVS12_RS02125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VSVS12_RS02130	COG0137	argininosuccinate synthase activity
VSVS12_RS02135	COG0165	Argininosuccinate lyase
VSVS12_RS02135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VSVS12_RS02150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSVS12_RS02155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VSVS12_RS02155	COG0678	peroxiredoxin activity
VSVS12_RS02175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VSVS12_RS02210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VSVS12_RS02220	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VSVS12_RS02225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VSVS12_RS02230	COG0546	phosphoglycolate phosphatase activity
VSVS12_RS02245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VSVS12_RS02250	COG3138	arginine N-succinyltransferase
VSVS12_RS02255	COG1012	belongs to the aldehyde dehydrogenase family
VSVS12_RS02270	COG3954	Phosphoribulokinase
VSVS12_RS02275	COG3089	Belongs to the UPF0270 family
VSVS12_RS02280	COG0429	hydrolase of the alpha beta-hydrolase fold
VSVS12_RS02290	COG0488	(ABC) transporter
VSVS12_RS02295	COG2249	NAD(P)H dehydrogenase (quinone) activity
VSVS12_RS02305	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VSVS12_RS02310	COG1047	Peptidyl-prolyl cis-trans
VSVS12_RS02315	COG1446	asparaginase
VSVS12_RS02320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VSVS12_RS02325	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VSVS12_RS02330	COG0402	S-adenosylhomocysteine deaminase activity
VSVS12_RS02335	COG0557	exoribonuclease II activity
VSVS12_RS02340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VSVS12_RS02345	COG0051	transcription antitermination factor activity, RNA binding
VSVS12_RS02350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VSVS12_RS02355	COG0088	Forms part of the polypeptide exit tunnel
VSVS12_RS02370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VSVS12_RS02375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VSVS12_RS02380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VSVS12_RS02405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VSVS12_RS02410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VSVS12_RS02425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VSVS12_RS02430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VSVS12_RS02440	COG1841	ribosomal large subunit assembly
VSVS12_RS02445	COG0200	Binds to the 23S rRNA
VSVS12_RS02450	COG0201	protein transport
VSVS12_RS02455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VSVS12_RS02460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VSVS12_RS02465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VSVS12_RS02475	COG0202	RNA polymerase activity
VSVS12_RS02480	COG0203	ribosomal protein L17
VSVS12_RS02490	COG0545	Peptidyl-prolyl cis-trans isomerase
VSVS12_RS02505	COG2153	protein acetylation
VSVS12_RS02515	COG0737	Belongs to the 5'-nucleotidase family
VSVS12_RS02520	COG1648	precorrin-2 dehydrogenase activity
VSVS12_RS02520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VSVS12_RS02535	COG0471	metal ion transport
VSVS12_RS02535	COG3273	potassium ion transport
VSVS12_RS02540	COG0529	Catalyzes the synthesis of activated sulfate
VSVS12_RS02550	COG0735	belongs to the Fur family
VSVS12_RS02575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VSVS12_RS02585	COG0175	sulfate reduction
VSVS12_RS02660	COG0646	methionine synthase
VSVS12_RS02660	COG1410	methionine synthase
VSVS12_RS02665	COG2239	Acts as a magnesium transporter
VSVS12_RS02670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_RS02675	COG1660	Displays ATPase and GTPase activities
VSVS12_RS02680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_RS02685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VSVS12_RS02695	COG1137	ATPase activity
VSVS12_RS02700	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VSVS12_RS02710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VSVS12_RS02715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VSVS12_RS02715	COG0517	IMP dehydrogenase activity
VSVS12_RS02725	COG1127	ABC transporter
VSVS12_RS02730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VSVS12_RS02735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VSVS12_RS02740	COG2854	intermembrane phospholipid transfer
VSVS12_RS02750	COG5007	Belongs to the BolA IbaG family
VSVS12_RS02795	COG0840	transmembrane signaling receptor activity
VSVS12_RS02820	COG0741	lytic transglycosylase activity
VSVS12_RS02825	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VSVS12_RS02835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VSVS12_RS02840	COG2066	Belongs to the glutaminase family
VSVS12_RS02845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VSVS12_RS02850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VSVS12_RS02860	COG1872	DUF167
VSVS12_RS02865	COG0762	integral membrane protein
VSVS12_RS02870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VSVS12_RS02875	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VSVS12_RS02890	COG0527	aspartate kinase activity
VSVS12_RS02895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VSVS12_RS02905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VSVS12_RS02920	COG0629	single-stranded DNA binding
VSVS12_RS02925	COG2200	EAL domain
VSVS12_RS02925	COG2199	diguanylate cyclase activity
VSVS12_RS02950	COG3267	Type II secretory pathway component ExeA
VSVS12_RS02950	COG3409	Peptidoglycan-binding domain 1 protein
VSVS12_RS02960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSVS12_RS02975	COG1459	type II secretion system
VSVS12_RS02985	COG2165	general secretion pathway protein
VSVS12_RS02990	COG2165	general secretion pathway protein
VSVS12_RS03025	COG1077	Cell shape determining protein MreB Mrl
VSVS12_RS03030	COG1792	Involved in formation and maintenance of cell shape
VSVS12_RS03035	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VSVS12_RS03040	COG0424	maF-like protein
VSVS12_RS03055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VSVS12_RS03060	COG0312	modulator of DNA gyrase
VSVS12_RS03120	COG0589	response to stress
VSVS12_RS03135	COG1438	arginine binding
VSVS12_RS03150	COG0142	geranyltranstransferase activity
VSVS12_RS03155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VSVS12_RS03165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VSVS12_RS03170	COG2966	Psort location CytoplasmicMembrane, score
VSVS12_RS03175	COG3610	response to peptide
VSVS12_RS03185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VSVS12_RS03195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VSVS12_RS03200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VSVS12_RS03205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VSVS12_RS03210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VSVS12_RS03215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VSVS12_RS03220	COG0251	oxidation-reduction process
VSVS12_RS03225	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VSVS12_RS03240	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VSVS12_RS03245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VSVS12_RS03255	COG0564	pseudouridine synthase activity
VSVS12_RS03260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VSVS12_RS03265	COG0525	valine-tRNA ligase activity
VSVS12_RS03270	COG2927	DNA polymerase III (CHI subunit)
VSVS12_RS03280	COG0795	lipopolysaccharide-transporting ATPase activity
VSVS12_RS03285	COG0795	lipopolysaccharide-transporting ATPase activity
VSVS12_RS03300	COG0716	FMN binding
VSVS12_RS03305	COG4974	Belongs to the 'phage' integrase family
VSVS12_RS03310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VSVS12_RS03315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VSVS12_RS03320	COG2186	Transcriptional regulator
VSVS12_RS03325	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VSVS12_RS03330	COG0508	dehydrogenase complex catalyzes the overall conversion of
VSVS12_RS03335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSVS12_RS03350	COG0288	reversible hydration of carbon dioxide
VSVS12_RS03355	COG0659	secondary active sulfate transmembrane transporter activity
VSVS12_RS03365	COG0659	secondary active sulfate transmembrane transporter activity
VSVS12_RS03370	COG1131	(ABC) transporter
VSVS12_RS03375	COG0842	Transport permease protein
VSVS12_RS03385	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VSVS12_RS03390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VSVS12_RS03395	COG0617	tRNA 3'-terminal CCA addition
VSVS12_RS03400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VSVS12_RS03405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VSVS12_RS03415	COG1643	Atp-dependent helicase
VSVS12_RS03420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VSVS12_RS03425	COG1752	Esterase of the alpha-beta hydrolase superfamily
VSVS12_RS03430	COG1049	propionate catabolic process, 2-methylcitrate cycle
VSVS12_RS03435	COG1929	Belongs to the glycerate kinase type-1 family
VSVS12_RS03440	COG2610	gluconate transmembrane transporter activity
VSVS12_RS03445	COG3835	regulator
VSVS12_RS03460	COG0004	ammonium transporteR
VSVS12_RS03465	COG1840	ABC-type Fe3 transport system, periplasmic component
VSVS12_RS03470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
VSVS12_RS03475	COG3842	ATPase activity
VSVS12_RS03485	COG0693	protein deglycase activity
VSVS12_RS03490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VSVS12_RS03505	COG2971	BadF BadG BcrA BcrD
VSVS12_RS03515	COG4608	Belongs to the ABC transporter superfamily
VSVS12_RS03520	COG0444	Belongs to the ABC transporter superfamily
VSVS12_RS03525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSVS12_RS03535	COG0747	negative chemotaxis
VSVS12_RS03540	COG2198	Histidine kinase
VSVS12_RS03540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_RS03540	COG2205	protein histidine kinase activity
VSVS12_RS03540	COG0784	Response regulator, receiver
VSVS12_RS03545	COG2813	Specifically methylates the guanine in position
VSVS12_RS03550	COG0628	permease
VSVS12_RS03560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VSVS12_RS03565	COG0316	Belongs to the HesB IscA family
VSVS12_RS03580	COG0739	heme binding
VSVS12_RS03585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VSVS12_RS03595	COG2027	D-alanyl-D-alanine carboxypeptidase
VSVS12_RS03600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VSVS12_RS03605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VSVS12_RS03610	COG1534	Rna-binding protein
VSVS12_RS03615	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VSVS12_RS03620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VSVS12_RS03625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VSVS12_RS03630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VSVS12_RS03635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VSVS12_RS03650	COG0779	Required for maturation of 30S ribosomal subunits
VSVS12_RS03655	COG0195	Participates in both transcription termination and antitermination
VSVS12_RS03665	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VSVS12_RS03685	COG0067	glutamate synthase
VSVS12_RS03685	COG0069	glutamate synthase activity
VSVS12_RS03685	COG0070	glutamate synthase
VSVS12_RS03690	COG1242	4 iron, 4 sulfur cluster binding
VSVS12_RS03695	COG4251	negative regulation of phosphorylation
VSVS12_RS03695	COG5001	Diguanylate cyclase
VSVS12_RS03695	COG3706	GGDEF domain
VSVS12_RS03695	COG2203	Gaf domain
VSVS12_RS03700	COG5002	protein histidine kinase activity
VSVS12_RS03700	COG2198	Histidine kinase
VSVS12_RS03700	COG0784	Response regulator, receiver
VSVS12_RS03715	COG0667	Aldo Keto reductase
VSVS12_RS03725	COG3066	DNA modification
VSVS12_RS03730	COG0494	nUDIX hydrolase
VSVS12_RS03745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VSVS12_RS03750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VSVS12_RS03760	COG1283	sodium-dependent phosphate transmembrane transporter activity
VSVS12_RS03765	COG0583	DNA-binding transcription factor activity
VSVS12_RS03770	COG0640	Transcriptional regulator
VSVS12_RS03775	COG0268	Binds directly to 16S ribosomal RNA
VSVS12_RS03780	COG0728	peptidoglycan biosynthetic process
VSVS12_RS03785	COG0196	riboflavin kinase activity
VSVS12_RS03800	COG1047	Peptidyl-prolyl cis-trans
VSVS12_RS03805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VSVS12_RS03810	COG1966	Carbon starvation protein
VSVS12_RS03820	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VSVS12_RS03830	COG3279	Response regulator of the LytR AlgR family
VSVS12_RS03835	COG3275	phosphorelay sensor kinase activity
VSVS12_RS03840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VSVS12_RS03845	COG0287	Prephenate dehydrogenase
VSVS12_RS03845	COG1605	Chorismate mutase
VSVS12_RS03850	COG0739	heme binding
VSVS12_RS03860	COG0488	(ABC) transporter
VSVS12_RS03870	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VSVS12_RS03875	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VSVS12_RS03880	COG5001	Diguanylate cyclase
VSVS12_RS03885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VSVS12_RS03890	COG0077	Prephenate dehydratase
VSVS12_RS03890	COG1605	Chorismate mutase
VSVS12_RS03895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VSVS12_RS03900	COG0741	lytic transglycosylase activity
VSVS12_RS03915	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSVS12_RS03920	COG0564	pseudouridine synthase activity
VSVS12_RS03925	COG1496	oxidoreductase activity
VSVS12_RS03930	COG0542	response to heat
VSVS12_RS03970	COG3335	DDE superfamily endonuclease
VSVS12_RS03995	COG0483	inositol monophosphate 1-phosphatase activity
VSVS12_RS04000	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VSVS12_RS04010	COG1104	cysteine desulfurase activity
VSVS12_RS04015	COG0822	iron-sulfur transferase activity
VSVS12_RS04020	COG0316	Belongs to the HesB IscA family
VSVS12_RS04025	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VSVS12_RS04035	COG0633	Ferredoxin
VSVS12_RS04040	COG2975	iron-sulfur cluster assembly
VSVS12_RS04050	COG0105	UTP biosynthetic process
VSVS12_RS04055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VSVS12_RS04060	COG0693	protein deglycase activity
VSVS12_RS04065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VSVS12_RS04070	COG3248	Nucleoside-binding outer membrane protein
VSVS12_RS04080	COG1595	DNA-templated transcription, initiation
VSVS12_RS04090	COG2211	Major facilitator Superfamily
VSVS12_RS04095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VSVS12_RS04110	COG0271	Belongs to the BolA IbaG family
VSVS12_RS04115	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VSVS12_RS04120	COG1805	sodium ion transport
VSVS12_RS04130	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VSVS12_RS04135	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VSVS12_RS04140	COG2871	sodium ion transport
VSVS12_RS04145	COG1477	protein flavinylation
VSVS12_RS04160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VSVS12_RS04165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VSVS12_RS04175	COG0733	neurotransmitter:sodium symporter activity
VSVS12_RS04180	COG3385	transposase activity
VSVS12_RS04190	COG0189	ligase activity
VSVS12_RS04195	COG0189	ligase activity
VSVS12_RS04195	COG4067	protein conserved in archaea
VSVS12_RS04200	COG2195	Cleaves the N-terminal amino acid of tripeptides
VSVS12_RS04205	COG2252	PERMEase
VSVS12_RS04215	COG1073	alpha beta
VSVS12_RS04230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VSVS12_RS04240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VSVS12_RS04240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VSVS12_RS04260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VSVS12_RS04270	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VSVS12_RS04295	COG0024	Methionine aminopeptidase
VSVS12_RS04310	COG0528	UMP kinase activity
VSVS12_RS04320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VSVS12_RS04325	COG0575	Belongs to the CDS family
VSVS12_RS04335	COG0750	zinc metalloprotease
VSVS12_RS04345	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VSVS12_RS04350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSVS12_RS04355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VSVS12_RS04375	COG0587	DNA-directed DNA polymerase activity
VSVS12_RS04380	COG0825	malonyl-CoA metabolic process
VSVS12_RS04390	COG0347	Belongs to the P(II) protein family
VSVS12_RS04395	COG3021	interspecies interaction between organisms
VSVS12_RS04405	COG0741	lytic transglycosylase activity
VSVS12_RS04405	COG1388	LysM domain
VSVS12_RS04410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSVS12_RS04415	COG2226	methyltransferase
VSVS12_RS04420	COG0328	RNA-DNA hybrid ribonuclease activity
VSVS12_RS04435	COG3385	transposase activity
VSVS12_RS04440	COG1960	acyl-CoA dehydrogenase activity
VSVS12_RS04445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VSVS12_RS04450	COG0121	glutamine amidotransferase
VSVS12_RS04460	COG1720	tRNA m6t6A37 methyltransferase activity
VSVS12_RS04475	COG1464	Belongs to the NlpA lipoprotein family
VSVS12_RS04480	COG2011	ABC-type metal ion transport system permease component
VSVS12_RS04490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VSVS12_RS04515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VSVS12_RS04525	COG2921	Belongs to the UPF0250 family
VSVS12_RS04530	COG1686	Belongs to the peptidase S11 family
VSVS12_RS04535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VSVS12_RS04540	COG0772	Belongs to the SEDS family
VSVS12_RS04545	COG0768	penicillin binding
VSVS12_RS04550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VSVS12_RS04555	COG0799	negative regulation of ribosome biogenesis
VSVS12_RS04560	COG1466	dna polymerase III delta subunit
VSVS12_RS04565	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VSVS12_RS04570	COG0495	leucyl-tRNA aminoacylation
VSVS12_RS04575	COG2888	peptidyl-tyrosine sulfation
VSVS12_RS04580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VSVS12_RS04585	COG4535	Mg2 and Co2 transporter CorC
VSVS12_RS04595	COG1702	phosphate starvation-inducible protein PhoH
VSVS12_RS04600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VSVS12_RS04605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VSVS12_RS04610	COG2190	(PTS) system
VSVS12_RS04615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VSVS12_RS04620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_RS04625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VSVS12_RS04630	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VSVS12_RS04635	COG3115	cell septum assembly
VSVS12_RS04660	COG1585	Membrane protein implicated in regulation of membrane protease activity
VSVS12_RS04665	COG0330	HflC and HflK could
VSVS12_RS04670	COG3118	belongs to the thioredoxin family
VSVS12_RS04675	COG0300	oxidoreductase activity
VSVS12_RS04680	COG1090	epimerase
VSVS12_RS04705	COG0622	Phosphoesterase
VSVS12_RS04725	COG3710	Transcriptional regulator
VSVS12_RS04730	COG0326	Molecular chaperone. Has ATPase activity
VSVS12_RS04740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VSVS12_RS04755	COG2217	Heavy metal translocating P-type atpase
VSVS12_RS04755	COG2608	mercury ion transmembrane transporter activity
VSVS12_RS04770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VSVS12_RS04810	COG2747	anti-sigma28 factor FlgM
VSVS12_RS04820	COG0784	Response regulator, receiver
VSVS12_RS04820	COG0835	chemotaxis
VSVS12_RS04825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VSVS12_RS04830	COG1815	bacterial-type flagellum-dependent cell motility
VSVS12_RS04850	COG4787	bacterial-type flagellum-dependent cell motility
VSVS12_RS04860	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VSVS12_RS04865	COG1706	bacterial-type flagellum-dependent cell motility
VSVS12_RS04870	COG1705	Flagellar rod assembly protein muramidase FlgJ
VSVS12_RS04870	COG3951	Flagellar rod assembly protein muramidase FlgJ
VSVS12_RS04885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VSVS12_RS04895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VSVS12_RS04980	COG0012	GTP binding
VSVS12_RS04990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VSVS12_RS04995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VSVS12_RS05000	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VSVS12_RS05005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VSVS12_RS05010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VSVS12_RS05015	COG2890	protein-(glutamine-N5) methyltransferase activity
VSVS12_RS05020	COG3094	Invasion gene expression up-regulator, SirB
VSVS12_RS05025	COG2912	Transglutaminase-like superfamily
VSVS12_RS05030	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VSVS12_RS05040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VSVS12_RS05050	COG2233	PERMEase
VSVS12_RS05070	COG1393	Belongs to the ArsC family
VSVS12_RS05075	COG4783	chaperone-mediated protein folding
VSVS12_RS05100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VSVS12_RS05110	COG0732	type I restriction modification DNA specificity domain
VSVS12_RS05115	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VSVS12_RS05145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSVS12_RS05170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSVS12_RS05180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VSVS12_RS05185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VSVS12_RS05190	COG2056	Na+-H+ antiporter family
VSVS12_RS05210	COG0346	lactoylglutathione lyase activity
VSVS12_RS05215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VSVS12_RS05220	COG4660	Part of a membrane complex involved in electron transport
VSVS12_RS05225	COG4659	FMN binding
VSVS12_RS05230	COG4658	electron transport chain
VSVS12_RS05235	COG4656	Part of a membrane complex involved in electron transport
VSVS12_RS05240	COG2878	Part of a membrane complex involved in electron transport
VSVS12_RS05245	COG4657	Part of a membrane complex involved in electron transport
VSVS12_RS05250	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VSVS12_RS05260	COG0556	nucleotide-excision repair
VSVS12_RS05265	COG2204	response regulator
VSVS12_RS05270	COG2198	Histidine kinase
VSVS12_RS05275	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VSVS12_RS05280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VSVS12_RS05285	COG0521	Mo-molybdopterin cofactor biosynthetic process
VSVS12_RS05290	COG0315	cyclic pyranopterin monophosphate synthase activity
VSVS12_RS05295	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VSVS12_RS05300	COG0314	molybdopterin synthase activity
VSVS12_RS05305	COG0517	IMP dehydrogenase activity
VSVS12_RS05305	COG0617	tRNA 3'-terminal CCA addition
VSVS12_RS05305	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VSVS12_RS05325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSVS12_RS05325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSVS12_RS05330	COG0489	protein tyrosine kinase activity
VSVS12_RS05335	COG0572	uridine kinase
VSVS12_RS05340	COG2982	Protein involved in outer membrane biogenesis
VSVS12_RS05350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VSVS12_RS05370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VSVS12_RS05375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VSVS12_RS05385	COG0123	including yeast histone deacetylase and acetoin utilization protein
VSVS12_RS05390	COG2199	diguanylate cyclase activity
VSVS12_RS05400	COG0626	cystathionine gamma-synthase activity
VSVS12_RS05410	COG2188	Transcriptional regulator
VSVS12_RS05415	COG3958	Transketolase
VSVS12_RS05435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_RS05445	COG0446	pyridine nucleotide-disulphide oxidoreductase
VSVS12_RS05455	COG0251	oxidation-reduction process
VSVS12_RS05460	COG2964	Protein conserved in bacteria
VSVS12_RS05465	COG1288	antiporter activity
VSVS12_RS05490	COG3083	sulfuric ester hydrolase activity
VSVS12_RS05495	COG3082	Protein of unknown function (DUF1414)
VSVS12_RS05515	COG1757	Na H antiporter
VSVS12_RS05520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VSVS12_RS05535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSVS12_RS05540	COG2095	MarC family integral membrane protein
VSVS12_RS05545	COG1012	belongs to the aldehyde dehydrogenase family
VSVS12_RS05545	COG1454	alcohol dehydrogenase
VSVS12_RS05550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VSVS12_RS05555	COG2894	cell division
VSVS12_RS05560	COG0850	regulation of cytokinetic process
VSVS12_RS05570	COG2951	lytic endotransglycosylase activity
VSVS12_RS05575	COG0583	DNA-binding transcription factor activity
VSVS12_RS05580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSVS12_RS05640	COG3046	protein related to deoxyribodipyrimidine photolyase
VSVS12_RS05645	COG0415	Belongs to the DNA photolyase family
VSVS12_RS05655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VSVS12_RS05660	COG1447	Phosphotransferase system cellobiose-specific component IIA
VSVS12_RS05675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_RS05680	COG0006	proline dipeptidase activity
VSVS12_RS05685	COG1363	Peptidase, m42
VSVS12_RS05710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_RS05715	COG3715	PTS system
VSVS12_RS05720	COG3716	PTS system mannose fructose sorbose family IID component
VSVS12_RS05750	COG1028	Short-chain dehydrogenase reductase Sdr
VSVS12_RS05760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSVS12_RS05770	COG0443	Heat shock 70 kDa protein
VSVS12_RS05775	COG0625	glutathione transferase activity
VSVS12_RS05795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VSVS12_RS05800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VSVS12_RS05805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VSVS12_RS05815	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VSVS12_RS05820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VSVS12_RS05830	COG0848	biopolymer transport protein
VSVS12_RS05835	COG0811	peptide transport
VSVS12_RS05850	COG3721	Heme iron utilization protein
VSVS12_RS05855	COG0748	coenzyme F420 binding
VSVS12_RS05865	COG2204	response regulator
VSVS12_RS05875	COG0544	peptidyl-prolyl cis-trans isomerase activity
VSVS12_RS05890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VSVS12_RS05895	COG0776	regulation of translation
VSVS12_RS05900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VSVS12_RS05905	COG1555	photosystem II stabilization
VSVS12_RS05910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VSVS12_RS05915	COG0539	negative regulation of cytoplasmic translation
VSVS12_RS05925	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VSVS12_RS05930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VSVS12_RS05945	COG0583	DNA-binding transcription factor activity
VSVS12_RS05960	COG4120	Belongs to the binding-protein-dependent transport system permease family
VSVS12_RS05970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VSVS12_RS05990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VSVS12_RS05995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VSVS12_RS06010	COG0252	asparaginase activity
VSVS12_RS06015	COG0616	signal peptide processing
VSVS12_RS06020	COG1902	pentaerythritol trinitrate reductase activity
VSVS12_RS06020	COG0446	pyridine nucleotide-disulphide oxidoreductase
VSVS12_RS06030	COG0788	formyltetrahydrofolate deformylase activity
VSVS12_RS06040	COG1199	ATP-dependent helicase activity
VSVS12_RS06045	COG1214	PFAM Peptidase M22, glycoprotease
VSVS12_RS06055	COG3065	identical protein binding
VSVS12_RS06060	COG1073	alpha beta
VSVS12_RS06060	COG2226	methyltransferase
VSVS12_RS06065	COG0318	PFAM AMP-dependent synthetase and ligase
VSVS12_RS06070	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VSVS12_RS06080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VSVS12_RS06085	COG0659	secondary active sulfate transmembrane transporter activity
VSVS12_RS06090	COG1530	ribonuclease E activity
VSVS12_RS06095	COG0564	pseudouridine synthase activity
VSVS12_RS06100	COG0424	maF-like protein
VSVS12_RS06105	COG1399	metal-binding, possibly nucleic acid-binding protein
VSVS12_RS06110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VSVS12_RS06120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VSVS12_RS06125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VSVS12_RS06150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VSVS12_RS06155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VSVS12_RS06165	COG0084	hydrolase, TatD family'
VSVS12_RS06170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_RS06170	COG1263	PTS System
VSVS12_RS06185	COG0733	neurotransmitter:sodium symporter activity
VSVS12_RS06200	COG4667	esterase of the alpha-beta hydrolase superfamily
VSVS12_RS06205	COG1940	carbohydrate kinase activity
VSVS12_RS06210	COG0835	chemotaxis
VSVS12_RS06210	COG0784	Response regulator, receiver
VSVS12_RS06230	COG1028	Short-chain dehydrogenase reductase Sdr
VSVS12_RS06235	COG0616	signal peptide processing
VSVS12_RS06250	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_RS06255	COG3716	PTS system mannose fructose sorbose family IID component
VSVS12_RS06260	COG3715	PTS system
VSVS12_RS06265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_RS06270	COG2222	sugar isomerase
VSVS12_RS06280	COG1349	DNA-binding transcription factor activity
VSVS12_RS06285	COG1278	Cold shock
VSVS12_RS06295	COG1349	DNA-binding transcription factor activity
VSVS12_RS06315	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VSVS12_RS06320	COG0436	Aminotransferase
VSVS12_RS06325	COG1169	isochorismate synthase
VSVS12_RS06330	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VSVS12_RS06340	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VSVS12_RS06350	COG0318	PFAM AMP-dependent synthetase and ligase
VSVS12_RS06355	COG1263	PTS System
VSVS12_RS06355	COG2190	(PTS) system
VSVS12_RS06355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_RS06360	COG0583	DNA-binding transcription factor activity
VSVS12_RS06365	COG2855	membrane
VSVS12_RS06370	COG0477	Major facilitator Superfamily
VSVS12_RS06390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VSVS12_RS06395	COG1522	sequence-specific DNA binding
VSVS12_RS06400	COG1946	Acyl-CoA thioesterase
VSVS12_RS06420	COG5001	Diguanylate cyclase
VSVS12_RS06420	COG5002	protein histidine kinase activity
VSVS12_RS06435	COG3064	Membrane
VSVS12_RS06445	COG3300	MHYT domain
VSVS12_RS06445	COG5001	Diguanylate cyclase
VSVS12_RS06450	COG0784	Response regulator, receiver
VSVS12_RS06450	COG2205	protein histidine kinase activity
VSVS12_RS06460	COG4221	oxidoreductase activity
VSVS12_RS06470	COG0601	transmembrane transport
VSVS12_RS06475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSVS12_RS06480	COG0444	Belongs to the ABC transporter superfamily
VSVS12_RS06500	COG0435	Glutathione S-transferase
VSVS12_RS06545	COG2221	Nitrite and sulphite reductase 4Fe-4S
VSVS12_RS06545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VSVS12_RS06550	COG3381	protein complex oligomerization
VSVS12_RS06555	COG0243	molybdopterin cofactor binding
VSVS12_RS06560	COG0437	4 iron, 4 sulfur cluster binding
VSVS12_RS06565	COG3302	dmso reductase anchor subunit
VSVS12_RS06575	COG0280	phosphate acetyltransferase
VSVS12_RS06575	COG0857	belongs to the CobB CobQ family
VSVS12_RS06585	COG3092	negative regulation of chromosome organization
VSVS12_RS06600	COG0686	Belongs to the AlaDH PNT family
VSVS12_RS06605	COG1522	sequence-specific DNA binding
VSVS12_RS06610	COG1674	ftsk spoiiie
VSVS12_RS06625	COG2186	Transcriptional regulator
VSVS12_RS06630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VSVS12_RS06635	COG1151	hydroxylamine reductase activity
VSVS12_RS06640	COG3604	Transcriptional regulator
VSVS12_RS06655	COG0537	adenosine 5'-monophosphoramidase activity
VSVS12_RS06680	COG3150	esterase
VSVS12_RS06685	COG1252	NADH dehydrogenase
VSVS12_RS06700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VSVS12_RS06710	COG4591	ABC-type transport system involved in lipoprotein release permease component
VSVS12_RS06715	COG1136	(ABC) transporter
VSVS12_RS06720	COG4591	ABC-type transport system involved in lipoprotein release permease component
VSVS12_RS06730	COG0658	competence protein
VSVS12_RS06730	COG2333	competence protein COMEC
VSVS12_RS06735	COG1132	(ABC) transporter
VSVS12_RS06745	COG2835	tetraacyldisaccharide 4'-kinase activity
VSVS12_RS06750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VSVS12_RS06755	COG2719	SpoVR family
VSVS12_RS06765	COG2766	serine protein kinase
VSVS12_RS06770	COG3713	MltA-interacting MipA family protein
VSVS12_RS06775	COG3013	Belongs to the UPF0304 family
VSVS12_RS06785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VSVS12_RS06795	COG1882	Formate acetyltransferase
VSVS12_RS06820	COG4160	amino acid transport
VSVS12_RS06830	COG3275	phosphorelay sensor kinase activity
VSVS12_RS06845	COG4591	ABC-type transport system involved in lipoprotein release permease component
VSVS12_RS06850	COG1136	(ABC) transporter
VSVS12_RS06885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VSVS12_RS06895	COG0443	Heat shock 70 kDa protein
VSVS12_RS06910	COG3706	GGDEF domain
VSVS12_RS06940	COG1643	Atp-dependent helicase
VSVS12_RS06955	COG1301	dicarboxylic acid transport
VSVS12_RS06965	COG0133	tryptophan synthase activity
VSVS12_RS06970	COG0135	phosphoribosylanthranilate isomerase activity
VSVS12_RS06970	COG0134	indole-3-glycerol-phosphate synthase activity
VSVS12_RS06975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VSVS12_RS06980	COG0512	Glutamine amidotransferase of anthranilate synthase
VSVS12_RS06985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VSVS12_RS06995	COG0613	PHP domain protein
VSVS12_RS07000	COG0009	L-threonylcarbamoyladenylate synthase
VSVS12_RS07005	COG1187	pseudouridine synthase activity
VSVS12_RS07010	COG0784	Response regulator, receiver
VSVS12_RS07010	COG2205	protein histidine kinase activity
VSVS12_RS07010	COG5002	protein histidine kinase activity
VSVS12_RS07015	COG3437	response regulator, receiver
VSVS12_RS07035	COG0242	peptide deformylase activity
VSVS12_RS07055	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VSVS12_RS07060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VSVS12_RS07065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VSVS12_RS07100	COG0596	Alpha beta hydrolase
VSVS12_RS07150	COG3341	Caulimovirus viroplasmin
VSVS12_RS07150	COG0328	RNA-DNA hybrid ribonuclease activity
VSVS12_RS07185	COG1187	pseudouridine synthase activity
VSVS12_RS07190	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VSVS12_RS07195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_RS07195	COG1263	PTS System
VSVS12_RS07205	COG2149	membrane
VSVS12_RS07235	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VSVS12_RS07250	COG2837	iron assimilation
VSVS12_RS07270	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VSVS12_RS07275	COG2030	dehydratase
VSVS12_RS07280	COG4670	ketone body catabolic process
VSVS12_RS07285	COG0583	DNA-binding transcription factor activity
VSVS12_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
VSVS12_RS07295	COG0183	Belongs to the thiolase family
VSVS12_RS07300	COG0484	heat shock protein binding
VSVS12_RS07305	COG0443	Heat shock 70 kDa protein
VSVS12_RS07315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VSVS12_RS07320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_RS07330	COG0701	Predicted permease
VSVS12_RS07340	COG3385	transposase activity
VSVS12_RS07350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VSVS12_RS07360	COG3383	formate dehydrogenase (NAD+) activity
VSVS12_RS07405	COG2226	methyltransferase
VSVS12_RS07430	COG2199	diguanylate cyclase activity
VSVS12_RS07475	COG0446	pyridine nucleotide-disulphide oxidoreductase
VSVS12_RS07500	COG0840	transmembrane signaling receptor activity
VSVS12_RS07530	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VSVS12_RS07550	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VSVS12_RS07555	COG1280	lysine exporter protein (LysE YggA)
VSVS12_RS07560	COG1115	amino acid carrier protein
VSVS12_RS07585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_RS07585	COG4191	Histidine kinase
VSVS12_RS07595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VSVS12_RS07600	COG1032	radical SAM domain protein
VSVS12_RS07625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VSVS12_RS07635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VSVS12_RS07640	COG1454	alcohol dehydrogenase
VSVS12_RS07640	COG1012	belongs to the aldehyde dehydrogenase family
VSVS12_RS07645	COG1737	Transcriptional regulator
VSVS12_RS07650	COG0076	glutamate decarboxylase activity
VSVS12_RS07660	COG2431	L-lysine efflux transmembrane transporter activity
VSVS12_RS07675	COG3070	regulator of competence-specific genes
VSVS12_RS07695	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_RS07715	COG2195	Cleaves the N-terminal amino acid of tripeptides
VSVS12_RS07725	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VSVS12_RS07735	COG0625	glutathione transferase activity
VSVS12_RS07765	COG0247	lactate metabolic process
VSVS12_RS07765	COG0277	FAD linked oxidase domain protein
VSVS12_RS07775	COG4160	amino acid transport
VSVS12_RS07780	COG4215	(ABC) transporter
VSVS12_RS07785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_RS07790	COG1126	abc transporter atp-binding protein
VSVS12_RS07810	COG2986	histidine ammonia-lyase
VSVS12_RS07815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VSVS12_RS07820	COG0010	Belongs to the arginase family
VSVS12_RS07825	COG1228	amidohydrolase
VSVS12_RS07830	COG2188	Transcriptional regulator
VSVS12_RS07835	COG4326	sporulation control protein
VSVS12_RS07855	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VSVS12_RS07860	COG0471	metal ion transport
VSVS12_RS07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_RS07865	COG4191	Histidine kinase
VSVS12_RS07880	COG0295	cytidine deaminase activity
VSVS12_RS07885	COG1346	cytolysis
VSVS12_RS07890	COG1380	Effector of murein hydrolase LrgA
VSVS12_RS07895	COG2925	Exonuclease
VSVS12_RS07900	COG0251	oxidation-reduction process
VSVS12_RS07910	COG0702	epimerase
VSVS12_RS07915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VSVS12_RS07920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VSVS12_RS07925	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VSVS12_RS07950	COG4139	cobalamin transport
VSVS12_RS07955	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VSVS12_RS07975	COG2814	Major facilitator Superfamily
VSVS12_RS07980	COG0583	DNA-binding transcription factor activity
VSVS12_RS07985	COG1914	H( )-stimulated, divalent metal cation uptake system
VSVS12_RS08000	COG1451	nucleotide metabolic process
VSVS12_RS08010	COG3063	Type IV pilus biogenesis stability protein PilW
VSVS12_RS08015	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VSVS12_RS08035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_RS08045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VSVS12_RS08060	COG0840	transmembrane signaling receptor activity
VSVS12_RS08065	COG0602	queuosine metabolic process
VSVS12_RS08075	COG3706	GGDEF domain
VSVS12_RS08115	COG1254	Belongs to the acylphosphatase family
VSVS12_RS08120	COG2920	part of a sulfur-relay system
VSVS12_RS08125	COG0670	Belongs to the BI1 family
VSVS12_RS08135	COG0765	amino acid transport
VSVS12_RS08140	COG4597	amino acid ABC transporter
VSVS12_RS08145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_RS08155	COG1666	GTP binding
VSVS12_RS08160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VSVS12_RS08180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VSVS12_RS08180	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VSVS12_RS08185	COG3008	intermembrane lipid transfer
VSVS12_RS08190	COG2995	paraquat-inducible protein a
VSVS12_RS08195	COG1132	(ABC) transporter
VSVS12_RS08200	COG1956	GAF domain-containing protein
VSVS12_RS08205	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VSVS12_RS08220	COG0308	aminopeptidase N
VSVS12_RS08240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VSVS12_RS08240	COG0116	Belongs to the methyltransferase superfamily
VSVS12_RS08250	COG0488	(ABC) transporter
VSVS12_RS08265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VSVS12_RS08270	COG1067	ATP-dependent peptidase activity
VSVS12_RS08275	COG3120	sequence-specific DNA binding
VSVS12_RS08290	COG3278	Belongs to the heme-copper respiratory oxidase family
VSVS12_RS08305	COG2010	Cytochrome c
VSVS12_RS08315	COG2217	Heavy metal translocating P-type atpase
VSVS12_RS08330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSVS12_RS08335	COG0589	response to stress
VSVS12_RS08360	COG3842	ATPase activity
VSVS12_RS08365	COG1176	ABC-type spermidine putrescine transport system, permease component I
VSVS12_RS08370	COG1177	transmembrane transport
VSVS12_RS08375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VSVS12_RS08380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VSVS12_RS08385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VSVS12_RS08390	COG0004	ammonium transporteR
VSVS12_RS08405	COG0437	4 iron, 4 sulfur cluster binding
VSVS12_RS08410	COG0243	molybdopterin cofactor binding
VSVS12_RS08410	COG3383	formate dehydrogenase (NAD+) activity
VSVS12_RS08440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VSVS12_RS08450	COG0488	(ABC) transporter
VSVS12_RS08455	COG0583	DNA-binding transcription factor activity
VSVS12_RS08485	COG2204	response regulator
VSVS12_RS08495	COG4662	Binding-protein-dependent transport system inner membrane component
VSVS12_RS08500	COG1122	ATPase activity
VSVS12_RS08520	COG1940	carbohydrate kinase activity
VSVS12_RS08525	COG3148	PFAM DTW domain containing protein
VSVS12_RS08540	COG0791	NLP P60 protein
VSVS12_RS08550	COG3001	Fructosamine kinase
VSVS12_RS08560	COG0307	riboflavin synthase, alpha
VSVS12_RS08565	COG0534	Mate efflux family protein
VSVS12_RS08585	COG1280	lysine exporter protein (LysE YggA)
VSVS12_RS08600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VSVS12_RS08605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VSVS12_RS08610	COG0583	DNA-binding transcription factor activity
VSVS12_RS08635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VSVS12_RS08645	COG0583	DNA-binding transcription factor activity
VSVS12_RS08680	COG1263	PTS System
VSVS12_RS08680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_RS08685	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VSVS12_RS08690	COG1737	Transcriptional regulator
VSVS12_RS08695	COG1793	dna ligase
VSVS12_RS08720	COG3437	response regulator, receiver
VSVS12_RS08720	COG2205	protein histidine kinase activity
VSVS12_RS08720	COG4999	Histidine kinase
VSVS12_RS08720	COG3850	Histidine kinase
VSVS12_RS08725	COG2204	response regulator
VSVS12_RS08735	COG0438	transferase activity, transferring glycosyl groups
VSVS12_RS08775	COG0297	glycogen (starch) synthase activity
VSVS12_RS08785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VSVS12_RS08795	COG3706	GGDEF domain
VSVS12_RS08800	COG0724	RNA recognition motif
VSVS12_RS08805	COG1940	carbohydrate kinase activity
VSVS12_RS08840	COG1126	abc transporter atp-binding protein
VSVS12_RS08845	COG0765	amino acid transport
VSVS12_RS08850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_RS08855	COG4597	amino acid ABC transporter
VSVS12_RS08870	COG0848	biopolymer transport protein
VSVS12_RS08875	COG0811	peptide transport
VSVS12_RS08880	COG0811	peptide transport
VSVS12_RS08890	COG4774	siderophore transport
VSVS12_RS08895	COG2205	protein histidine kinase activity
VSVS12_RS08900	COG0745	RESPONSE REGULATOR receiver
VSVS12_RS08910	COG2358	TRAP transporter, solute receptor (TAXI family
VSVS12_RS08915	COG0584	glycerophosphoryl diester phosphodiesterase
VSVS12_RS08925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VSVS12_RS08935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VSVS12_RS08940	COG1328	CTP reductase activity
VSVS12_RS08945	COG0840	transmembrane signaling receptor activity
VSVS12_RS08965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VSVS12_RS08975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VSVS12_RS08980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VSVS12_RS08985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VSVS12_RS09010	COG0019	diaminopimelate decarboxylase activity
VSVS12_RS09030	COG2885	chlorophyll binding
VSVS12_RS09035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VSVS12_RS09045	COG0577	efflux transmembrane transporter activity
VSVS12_RS09050	COG1136	(ABC) transporter
VSVS12_RS09055	COG0534	Mate efflux family protein
VSVS12_RS09060	COG0702	epimerase
VSVS12_RS09065	COG5002	protein histidine kinase activity
VSVS12_RS09065	COG5001	Diguanylate cyclase
VSVS12_RS09070	COG1115	amino acid carrier protein
VSVS12_RS09110	COG2814	Major facilitator Superfamily
VSVS12_RS09120	COG1061	Type III restriction enzyme res subunit
VSVS12_RS09150	COG0586	Pfam SNARE associated Golgi protein
VSVS12_RS09195	COG0783	Belongs to the Dps family
VSVS12_RS09205	COG1609	Transcriptional regulator
VSVS12_RS09215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_RS09220	COG1447	Phosphotransferase system cellobiose-specific component IIA
VSVS12_RS09250	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VSVS12_RS09265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSVS12_RS09270	COG3108	Peptidase M15
VSVS12_RS09275	COG2989	Protein conserved in bacteria
VSVS12_RS09300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VSVS12_RS09320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VSVS12_RS09335	COG3106	COG3106 Predicted ATPase
VSVS12_RS09350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VSVS12_RS09355	COG2205	protein histidine kinase activity
VSVS12_RS09355	COG0784	Response regulator, receiver
VSVS12_RS09365	COG0494	nUDIX hydrolase
VSVS12_RS09370	COG0814	amino acid
VSVS12_RS09375	COG1760	l-serine dehydratase
VSVS12_RS09385	COG0720	synthase
VSVS12_RS09390	COG0840	transmembrane signaling receptor activity
VSVS12_RS09400	COG0017	Asparaginyl-tRNA synthetase
VSVS12_RS09435	COG1448	Aminotransferase
VSVS12_RS09455	COG0281	malic enzyme
VSVS12_RS09465	COG2949	membrane
VSVS12_RS09490	COG0492	ferredoxin-NADP+ reductase activity
VSVS12_RS09495	COG4988	ABC transporter
VSVS12_RS09500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VSVS12_RS09505	COG0006	proline dipeptidase activity
VSVS12_RS09510	COG1522	sequence-specific DNA binding
VSVS12_RS09515	COG1012	belongs to the aldehyde dehydrogenase family
VSVS12_RS09520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VSVS12_RS09545	COG0513	Belongs to the DEAD box helicase family
VSVS12_RS09590	COG1309	transcriptional regulator
VSVS12_RS09595	COG3153	acetyltransferase
VSVS12_RS09685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSVS12_RS09695	COG1012	belongs to the aldehyde dehydrogenase family
VSVS12_RS09705	COG0583	DNA-binding transcription factor activity
VSVS12_RS09720	COG0513	Belongs to the DEAD box helicase family
VSVS12_RS09730	COG0840	transmembrane signaling receptor activity
VSVS12_RS09740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSVS12_RS09750	COG1301	dicarboxylic acid transport
VSVS12_RS09755	COG1252	NADH dehydrogenase
VSVS12_RS09770	COG2188	Transcriptional regulator
VSVS12_RS09780	COG0110	maltose O-acetyltransferase activity
VSVS12_RS09795	COG0583	DNA-binding transcription factor activity
VSVS12_RS09800	COG0534	Mate efflux family protein
VSVS12_RS09820	COG0072	phenylalanine-tRNA ligase activity
VSVS12_RS09820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSVS12_RS09845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VSVS12_RS09860	COG3706	GGDEF domain
VSVS12_RS09895	COG0322	excinuclease ABC activity
VSVS12_RS09900	COG2197	response regulator
VSVS12_RS09915	COG0417	DNA replication proofreading
VSVS12_RS09920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_RS09940	COG0776	regulation of translation
VSVS12_RS09960	COG1607	acyl-coa hydrolase
VSVS12_RS09965	COG2350	Protein conserved in bacteria
VSVS12_RS09980	COG3313	Fe-S protein
VSVS12_RS09990	COG4134	Bacterial extracellular solute-binding protein
VSVS12_RS09995	COG4135	transport system, permease component
VSVS12_RS10000	COG4136	ATPase activity
VSVS12_RS10005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VSVS12_RS10020	COG0564	pseudouridine synthase activity
VSVS12_RS10030	COG0733	neurotransmitter:sodium symporter activity
VSVS12_RS10045	COG2818	Glycosylase
VSVS12_RS10050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_RS10055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_RS10075	COG1842	Phage shock protein A
VSVS12_RS10080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VSVS12_RS10090	COG4168	peptide transport system, permease
VSVS12_RS10105	COG4172	Belongs to the ABC transporter superfamily
VSVS12_RS10110	COG1227	inorganic diphosphatase activity
VSVS12_RS10140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VSVS12_RS10145	COG0131	Imidazoleglycerol-phosphate dehydratase
VSVS12_RS10145	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VSVS12_RS10150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VSVS12_RS10155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VSVS12_RS10165	COG1757	Na H antiporter
VSVS12_RS10170	COG2916	Histone family protein nucleoid-structuring protein H-NS
VSVS12_RS10175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSVS12_RS10185	COG0482	sulfurtransferase activity
VSVS12_RS10195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VSVS12_RS10215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VSVS12_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
VSVS12_RS10245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VSVS12_RS10250	COG2226	methyltransferase
VSVS12_RS10255	COG0156	8-amino-7-oxononanoate synthase activity
VSVS12_RS10265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VSVS12_RS10280	COG1199	ATP-dependent helicase activity
VSVS12_RS10285	COG0730	response to heat
VSVS12_RS10290	COG3923	Primosomal replication protein n
VSVS12_RS10300	COG2850	peptidyl-arginine hydroxylation
VSVS12_RS10315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_RS10325	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VSVS12_RS10330	COG1960	acyl-CoA dehydrogenase activity
VSVS12_RS10335	COG1309	transcriptional regulator
VSVS12_RS10345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VSVS12_RS10350	COG0463	Glycosyl transferase, family 2
VSVS12_RS10355	COG0745	RESPONSE REGULATOR receiver
VSVS12_RS10360	COG5002	protein histidine kinase activity
VSVS12_RS10360	COG3850	Histidine kinase
VSVS12_RS10375	COG1858	cytochrome C peroxidase
VSVS12_RS10380	COG0784	Response regulator, receiver
VSVS12_RS10380	COG2205	protein histidine kinase activity
VSVS12_RS10390	COG0402	S-adenosylhomocysteine deaminase activity
VSVS12_RS10395	COG5413	integral membrane protein
VSVS12_RS10410	COG4260	virion core protein, lumpy skin disease virus
VSVS12_RS10430	COG0848	biopolymer transport protein
VSVS12_RS10435	COG0811	peptide transport
VSVS12_RS10440	COG0811	peptide transport
VSVS12_RS10450	COG4771	TonB-dependent receptor
VSVS12_RS10455	COG4178	(ABC) transporter
VSVS12_RS10460	COG0612	Peptidase, M16
VSVS12_RS10465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSVS12_RS10475	COG1397	ADP-ribosylglycohydrolase
VSVS12_RS10505	COG2205	protein histidine kinase activity
VSVS12_RS10505	COG0784	Response regulator, receiver
VSVS12_RS10520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VSVS12_RS10525	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VSVS12_RS10530	COG2885	chlorophyll binding
VSVS12_RS10535	COG0823	Involved in the tonB-independent uptake of proteins
VSVS12_RS10550	COG0811	peptide transport
VSVS12_RS10555	COG0824	Thioesterase
VSVS12_RS10565	COG4890	Cyd operon protein YbgT
VSVS12_RS10570	COG1294	oxidase, subunit
VSVS12_RS10575	COG1271	oxidase subunit
VSVS12_RS10580	COG2255	four-way junction helicase activity
VSVS12_RS10585	COG0632	four-way junction helicase activity
VSVS12_RS10600	COG0243	molybdopterin cofactor binding
VSVS12_RS10605	COG3005	denitrification pathway
VSVS12_RS10610	COG4459	periplasmic nitrate reductase
VSVS12_RS10615	COG0390	transport system, permease component
VSVS12_RS10620	COG2116	formate transmembrane transporter activity
VSVS12_RS10635	COG0583	DNA-binding transcription factor activity
VSVS12_RS10650	COG0542	response to heat
VSVS12_RS10655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VSVS12_RS10660	COG1278	Cold shock
VSVS12_RS10670	COG1187	pseudouridine synthase activity
VSVS12_RS10685	COG3118	belongs to the thioredoxin family
VSVS12_RS10690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VSVS12_RS10695	COG1801	Protein of unknown function DUF72
VSVS12_RS10700	COG4106	trans-aconitate 2-methyltransferase activity
VSVS12_RS10705	COG0500	methyltransferase
VSVS12_RS10710	COG0189	ligase activity
VSVS12_RS10710	COG4067	protein conserved in archaea
VSVS12_RS10730	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VSVS12_RS10735	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VSVS12_RS10740	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VSVS12_RS10745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VSVS12_RS10750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VSVS12_RS10755	COG0745	RESPONSE REGULATOR receiver
VSVS12_RS10760	COG3381	protein complex oligomerization
VSVS12_RS10765	COG1609	Transcriptional regulator
VSVS12_RS10770	COG3070	regulator of competence-specific genes
VSVS12_RS10785	COG0596	Alpha beta hydrolase
VSVS12_RS10790	COG0297	glycogen (starch) synthase activity
VSVS12_RS10795	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VSVS12_RS10800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VSVS12_RS10815	COG3134	Outer membrane lipoprotein
VSVS12_RS10825	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VSVS12_RS10830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VSVS12_RS10835	COG1435	thymidine kinase activity
VSVS12_RS10840	COG0215	cysteine-tRNA ligase activity
VSVS12_RS10845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VSVS12_RS10850	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSVS12_RS10855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VSVS12_RS10860	COG3012	SEC-C Motif Domain Protein
VSVS12_RS10865	COG3139	Protein of unknown function (DUF1315)
VSVS12_RS10875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VSVS12_RS10880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSVS12_RS10890	COG2226	methyltransferase
VSVS12_RS10905	COG0668	transmembrane transport
VSVS12_RS10915	COG2261	transglycosylase associated protein
VSVS12_RS10930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VSVS12_RS10940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VSVS12_RS10950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VSVS12_RS10955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VSVS12_RS10960	COG2832	Protein of unknown function (DUF454)
VSVS12_RS10965	COG0745	RESPONSE REGULATOR receiver
VSVS12_RS10970	COG0583	DNA-binding transcription factor activity
VSVS12_RS10975	COG0778	Nitroreductase
VSVS12_RS10980	COG1024	Enoyl-CoA hydratase
VSVS12_RS10980	COG1250	3-hydroxyacyl-CoA dehydrogenase
VSVS12_RS10985	COG0183	Belongs to the thiolase family
VSVS12_RS11005	COG2067	long-chain fatty acid transport protein
VSVS12_RS11015	COG4235	cytochrome complex assembly
VSVS12_RS11020	COG3088	subunit of a heme lyase
VSVS12_RS11020	COG4235	cytochrome complex assembly
VSVS12_RS11025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VSVS12_RS11030	COG1138	Cytochrome C-type biogenesis protein
VSVS12_RS11045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VSVS12_RS11050	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VSVS12_RS11055	COG4133	protoheme IX ABC transporter activity
VSVS12_RS11065	COG0835	chemotaxis
VSVS12_RS11075	COG1192	Involved in chromosome partitioning
VSVS12_RS11080	COG2201	protein-glutamate methylesterase activity
VSVS12_RS11085	COG0643	Histidine kinase
VSVS12_RS11085	COG2198	Histidine kinase
VSVS12_RS11085	COG0784	Response regulator, receiver
VSVS12_RS11090	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VSVS12_RS11125	COG2062	phosphohistidine phosphatase, SixA
VSVS12_RS11130	COG1025	Belongs to the peptidase M16 family
VSVS12_RS11135	COG3102	Protein conserved in bacteria
VSVS12_RS11155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VSVS12_RS11160	COG1918	ferrous iron import across plasma membrane
VSVS12_RS11170	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VSVS12_RS11175	COG1121	(ABC) transporter
VSVS12_RS11180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VSVS12_RS11185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VSVS12_RS11190	COG1286	toxin biosynthetic process
VSVS12_RS11195	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VSVS12_RS11200	COG0285	dihydrofolate synthase activity
VSVS12_RS11205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VSVS12_RS11210	COG0101	tRNA pseudouridine synthase activity
VSVS12_RS11220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VSVS12_RS11225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSVS12_RS11230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VSVS12_RS11265	COG3101	peptidyl-lysine hydroxylation
VSVS12_RS11270	COG2860	membrane
VSVS12_RS11275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VSVS12_RS11280	COG2890	protein-(glutamine-N5) methyltransferase activity
VSVS12_RS11285	COG2840	Smr protein MutS2
VSVS12_RS11300	COG1684	flagellar biosynthetic protein fliR
VSVS12_RS11305	COG1987	bacterial-type flagellum assembly
VSVS12_RS11355	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VSVS12_RS11365	COG1677	Flagellar hook-basal body complex protein FliE
VSVS12_RS11385	COG1516	flagellar protein fliS
VSVS12_RS11395	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VSVS12_RS11400	COG1334	flagellar protein FlaG
VSVS12_RS11405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VSVS12_RS11420	COG2837	iron assimilation
VSVS12_RS11430	COG4235	cytochrome complex assembly
VSVS12_RS11430	COG3088	subunit of a heme lyase
VSVS12_RS11440	COG1138	Cytochrome C-type biogenesis protein
VSVS12_RS11445	COG3301	Polysulphide reductase, NrfD
VSVS12_RS11450	COG0437	4 iron, 4 sulfur cluster binding
VSVS12_RS11485	COG1393	Belongs to the ArsC family
VSVS12_RS11505	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VSVS12_RS11515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VSVS12_RS11515	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VSVS12_RS11530	COG1611	Belongs to the LOG family
VSVS12_RS11540	COG3385	transposase activity
VSVS12_RS11545	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VSVS12_RS11550	COG2363	Small membrane protein
VSVS12_RS11560	COG0583	DNA-binding transcription factor activity
VSVS12_RS11580	COG0301	tRNA thio-modification
VSVS12_RS11580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSVS12_RS11585	COG1360	Flagellar Motor Protein
VSVS12_RS11590	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VSVS12_RS11595	COG1722	exodeoxyribonuclease VII activity
VSVS12_RS11600	COG0142	geranyltranstransferase activity
VSVS12_RS11605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VSVS12_RS11625	COG0564	pseudouridine synthase activity
VSVS12_RS11630	COG3098	single-species biofilm formation
VSVS12_RS11665	COG0508	dehydrogenase complex catalyzes the overall conversion of
VSVS12_RS11670	COG0567	Dehydrogenase, E1 component
VSVS12_RS11675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VSVS12_RS11680	COG1053	succinate dehydrogenase
VSVS12_RS11685	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VSVS12_RS11700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VSVS12_RS11715	COG0033	Phosphoglucomutase
VSVS12_RS11720	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VSVS12_RS11725	COG0596	Alpha beta hydrolase
VSVS12_RS11735	COG0716	FMN binding
VSVS12_RS11755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_RS11755	COG1263	PTS System
VSVS12_RS11755	COG2190	(PTS) system
VSVS12_RS11760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VSVS12_RS11765	COG1940	carbohydrate kinase activity
VSVS12_RS11765	COG1846	Transcriptional regulator
VSVS12_RS11770	COG4651	solute:proton antiporter activity
VSVS12_RS11770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VSVS12_RS11775	COG0367	asparagine synthase
VSVS12_RS11780	COG3104	oligopeptide transport
VSVS12_RS11800	COG2840	Smr protein MutS2
VSVS12_RS11805	COG1187	pseudouridine synthase activity
VSVS12_RS11810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VSVS12_RS11815	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VSVS12_RS11820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VSVS12_RS11845	COG0047	phosphoribosylformylglycinamidine synthase activity
VSVS12_RS11845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VSVS12_RS11850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VSVS12_RS11855	COG0590	tRNA wobble adenosine to inosine editing
VSVS12_RS11860	COG1253	flavin adenine dinucleotide binding
VSVS12_RS11865	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VSVS12_RS11895	COG0484	heat shock protein binding
VSVS12_RS11915	COG1301	dicarboxylic acid transport
VSVS12_RS11920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VSVS12_RS11925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VSVS12_RS11935	COG0497	DNA recombination
VSVS12_RS11940	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSVS12_RS11945	COG2914	Belongs to the UPF0125 (RnfH) family
VSVS12_RS11950	COG2867	negative regulation of translational initiation
VSVS12_RS11970	COG0668	transmembrane transport
VSVS12_RS11980	COG0402	S-adenosylhomocysteine deaminase activity
VSVS12_RS11990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VSVS12_RS11990	COG3153	acetyltransferase
VSVS12_RS11995	COG0840	transmembrane signaling receptor activity
VSVS12_RS12000	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VSVS12_RS12005	COG1263	PTS System
VSVS12_RS12005	COG2190	(PTS) system
VSVS12_RS12005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_RS12010	COG2354	Protein conserved in bacteria
VSVS12_RS12015	COG2873	o-acetylhomoserine
VSVS12_RS12020	COG1115	amino acid carrier protein
VSVS12_RS12025	COG1584	GPR1 FUN34 yaaH family protein
VSVS12_RS12030	COG1757	Na H antiporter
VSVS12_RS12035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VSVS12_RS12035	COG0519	Catalyzes the synthesis of GMP from XMP
VSVS12_RS12040	COG0516	GMP reductase activity
VSVS12_RS12040	COG0517	IMP dehydrogenase activity
VSVS12_RS12045	COG1570	exodeoxyribonuclease VII activity
VSVS12_RS12060	COG1160	GTP binding
VSVS12_RS12065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSVS12_RS12070	COG2976	Protein conserved in bacteria
VSVS12_RS12075	COG0124	histidyl-tRNA synthetase
VSVS12_RS12080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VSVS12_RS12085	COG1426	Protein conserved in bacteria
VSVS12_RS12090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VSVS12_RS12095	COG2166	iron-sulfur cluster assembly
VSVS12_RS12100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VSVS12_RS12105	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VSVS12_RS12125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VSVS12_RS12130	COG1074	ATP-dependent DNA helicase activity
VSVS12_RS12135	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VSVS12_RS12145	COG0583	DNA-binding transcription factor activity
VSVS12_RS12150	COG3141	response to X-ray
VSVS12_RS12155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_RS12160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_RS12185	COG3142	Participates in the control of copper homeostasis
VSVS12_RS12190	COG0704	Plays a role in the regulation of phosphate uptake
VSVS12_RS12195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VSVS12_RS12200	COG0581	inorganic phosphate transmembrane transporter activity
VSVS12_RS12210	COG0248	Ppx GppA phosphatase
VSVS12_RS12220	COG5002	protein histidine kinase activity
VSVS12_RS12230	COG2974	May be involved in recombination
VSVS12_RS12235	COG0826	peptidase U32
VSVS12_RS12240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VSVS12_RS12260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VSVS12_RS12265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VSVS12_RS12270	COG1862	Preprotein translocase
VSVS12_RS12275	COG0343	queuine tRNA-ribosyltransferase activity
VSVS12_RS12280	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VSVS12_RS12290	COG0517	IMP dehydrogenase activity
VSVS12_RS12300	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VSVS12_RS12305	COG0583	DNA-binding transcription factor activity
VSVS12_RS12310	COG0450	alkyl hydroperoxide reductase
VSVS12_RS12325	COG2171	N-acyltransferase activity
VSVS12_RS12355	COG0583	DNA-binding transcription factor activity
VSVS12_RS12415	COG4964	Belongs to the GSP D family
VSVS12_RS12450	COG1022	Amp-dependent synthetase and ligase
VSVS12_RS12455	COG0583	DNA-binding transcription factor activity
VSVS12_RS12460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VSVS12_RS12465	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VSVS12_RS12495	COG0813	purine-nucleoside phosphorylase activity
VSVS12_RS12500	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VSVS12_RS12505	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VSVS12_RS12515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSVS12_RS12520	COG0084	hydrolase, TatD family'
VSVS12_RS12525	COG3022	response to hydroperoxide
VSVS12_RS12530	COG1115	amino acid carrier protein
VSVS12_RS12545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VSVS12_RS12550	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VSVS12_RS12555	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VSVS12_RS12560	COG3397	chitin binding
VSVS12_RS12565	COG0583	DNA-binding transcription factor activity
VSVS12_RS12580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VSVS12_RS12585	COG0505	Belongs to the CarA family
VSVS12_RS12595	COG0494	nUDIX hydrolase
VSVS12_RS12610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VSVS12_RS12615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VSVS12_RS12620	COG0849	cell division
VSVS12_RS12625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VSVS12_RS12635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VSVS12_RS12640	COG0772	Belongs to the SEDS family
VSVS12_RS12655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VSVS12_RS12660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VSVS12_RS12665	COG0768	penicillin binding
VSVS12_RS12670	COG3116	cell division
VSVS12_RS12675	COG0275	rRNA processing
VSVS12_RS12690	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VSVS12_RS12695	COG3107	peptidoglycan biosynthetic process
VSVS12_RS12705	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VSVS12_RS12710	COG2823	Periplasmic or secreted lipoprotein
VSVS12_RS12715	COG2969	positive regulation of protein catabolic process
VSVS12_RS12720	COG0625	glutathione transferase activity
VSVS12_RS12725	COG2857	Cytochrome c1
VSVS12_RS12730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VSVS12_RS12735	COG0723	plastoquinol--plastocyanin reductase activity
VSVS12_RS12740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VSVS12_RS12745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VSVS12_RS12750	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VSVS12_RS12755	COG3105	Protein conserved in bacteria
VSVS12_RS12760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSVS12_RS12765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSVS12_RS12780	COG3150	esterase
VSVS12_RS12790	COG3151	Protein conserved in bacteria
VSVS12_RS12795	COG0494	nUDIX hydrolase
VSVS12_RS12800	COG1538	Outer membrane efflux protein
VSVS12_RS12810	COG2204	response regulator
VSVS12_RS12820	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VSVS12_RS12830	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VSVS12_RS12835	COG0513	Belongs to the DEAD box helicase family
VSVS12_RS12840	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VSVS12_RS12845	COG0456	acetyltransferase
VSVS12_RS12855	COG3153	acetyltransferase
VSVS12_RS12860	COG3154	lipid carrier protein
VSVS12_RS12870	COG0826	peptidase U32
VSVS12_RS12875	COG0826	peptidase U32
VSVS12_RS12890	COG0534	Mate efflux family protein
VSVS12_RS12905	COG1185	polyribonucleotide nucleotidyltransferase activity
VSVS12_RS12910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VSVS12_RS12915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VSVS12_RS12925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VSVS12_RS12930	COG2860	membrane
VSVS12_RS12935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VSVS12_RS12940	COG0083	homoserine kinase activity
VSVS12_RS12955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VSVS12_RS12965	COG0745	RESPONSE REGULATOR receiver
VSVS12_RS12970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VSVS12_RS12970	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VSVS12_RS12975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VSVS12_RS12985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSVS12_RS12990	COG3025	triphosphatase activity
VSVS12_RS12995	COG1392	Phosphate transport regulator
VSVS12_RS13000	COG0306	phosphate transporter
VSVS12_RS13005	COG4991	sh3 domain protein
VSVS12_RS13015	COG3409	Peptidoglycan-binding domain 1 protein
VSVS12_RS13015	COG3267	Type II secretory pathway component ExeA
VSVS12_RS13020	COG0617	tRNA 3'-terminal CCA addition
VSVS12_RS13025	COG0148	phosphopyruvate hydratase activity
VSVS12_RS13035	COG3956	TIGRFAM MazG family protein
VSVS12_RS13040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VSVS12_RS13050	COG4999	Histidine kinase
VSVS12_RS13050	COG3437	response regulator, receiver
VSVS12_RS13050	COG3850	Histidine kinase
VSVS12_RS13050	COG2205	protein histidine kinase activity
VSVS12_RS13060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VSVS12_RS13065	COG1381	Involved in DNA repair and RecF pathway recombination
VSVS12_RS13070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VSVS12_RS13085	COG0481	GTPase activity
VSVS12_RS13090	COG3086	response to oxidative stress
VSVS12_RS13095	COG3026	antisigma factor binding
VSVS12_RS13105	COG1595	DNA-templated transcription, initiation
VSVS12_RS13110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VSVS12_RS13120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VSVS12_RS13140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VSVS12_RS13145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VSVS12_RS13150	COG3079	Belongs to the UPF0149 family
VSVS12_RS13165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VSVS12_RS13170	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VSVS12_RS13175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSVS12_RS13185	COG0028	Belongs to the TPP enzyme family
VSVS12_RS13190	COG1022	Amp-dependent synthetase and ligase
VSVS12_RS13195	COG0583	DNA-binding transcription factor activity
VSVS12_RS13200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VSVS12_RS13205	COG0473	3-isopropylmalate dehydrogenase activity
VSVS12_RS13215	COG0066	3-isopropylmalate dehydratase activity
VSVS12_RS13270	COG1609	Transcriptional regulator
VSVS12_RS13275	COG3394	polysaccharide catabolic process
VSVS12_RS13280	COG1486	melibiose metabolic process
VSVS12_RS13285	COG1447	Phosphotransferase system cellobiose-specific component IIA
VSVS12_RS13290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_RS13295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_RS13300	COG0840	transmembrane signaling receptor activity
VSVS12_RS13315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VSVS12_RS13385	COG2378	regulation of single-species biofilm formation
VSVS12_RS13500	COG1854	S-ribosylhomocysteine lyase activity
VSVS12_RS13510	COG2918	glutathione biosynthetic process
VSVS12_RS13515	COG0612	Peptidase, M16
VSVS12_RS13520	COG1238	metal cluster binding
VSVS12_RS13530	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VSVS12_RS13535	COG5016	pyruvate
VSVS12_RS13535	COG0511	ligase activity, forming carbon-carbon bonds
VSVS12_RS13540	COG3630	sodium ion export across plasma membrane
VSVS12_RS13585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VSVS12_RS13590	COG0527	aspartate kinase activity
VSVS12_RS13595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VSVS12_RS13600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VSVS12_RS13605	COG1546	Belongs to the CinA family
VSVS12_RS13620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSVS12_RS13625	COG1459	type II secretion system
VSVS12_RS13635	COG0237	dephospho-CoA kinase activity
VSVS12_RS13640	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VSVS12_RS13645	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VSVS12_RS13650	COG0335	large ribosomal subunit rRNA binding
VSVS12_RS13660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VSVS12_RS13670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VSVS12_RS13675	COG4137	Cytochrome C assembly protein
VSVS12_RS13680	COG4536	flavin adenine dinucleotide binding
VSVS12_RS13685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VSVS12_RS13690	COG1388	LysM domain
VSVS12_RS13690	COG4942	peptidase
VSVS12_RS13700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VSVS12_RS13705	COG0585	pseudouridine synthase activity
VSVS12_RS13715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VSVS12_RS13720	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VSVS12_RS13725	COG1968	undecaprenyl-diphosphatase activity
VSVS12_RS13730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VSVS12_RS13735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VSVS12_RS13740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VSVS12_RS13745	COG0596	Alpha beta hydrolase
VSVS12_RS13750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VSVS12_RS13755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VSVS12_RS13760	COG1610	YqeY-like protein
VSVS12_RS13765	COG0358	DNA primase activity
VSVS12_RS13780	COG0582	viral genome integration into host DNA
VSVS12_RS13790	COG2963	transposase activity
VSVS12_RS13845	COG2003	Belongs to the UPF0758 family
VSVS12_RS13895	COG3706	GGDEF domain
VSVS12_RS13900	COG2252	PERMEase
VSVS12_RS13915	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VSVS12_RS13925	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VSVS12_RS13935	COG3916	Acyl-homoserine-lactone synthase
VSVS12_RS13955	COG1349	DNA-binding transcription factor activity
VSVS12_RS13960	COG0469	pyruvate kinase activity
VSVS12_RS13980	COG0668	transmembrane transport
VSVS12_RS13985	COG0191	fructose-bisphosphate aldolase activity
VSVS12_RS13990	COG0126	phosphoglycerate kinase activity
VSVS12_RS13995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSVS12_RS14005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VSVS12_RS14020	COG3091	SprT-like family
VSVS12_RS14025	COG2356	endonuclease I
VSVS12_RS14030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VSVS12_RS14035	COG0189	ligase activity
VSVS12_RS14040	COG1678	Uncharacterized ACR, COG1678
VSVS12_RS14045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VSVS12_RS14050	COG0312	modulator of DNA gyrase
VSVS12_RS14055	COG3028	Belongs to the UPF0307 family
VSVS12_RS14060	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VSVS12_RS14065	COG1178	ABC-type Fe3 transport system permease component
VSVS12_RS14070	COG4143	(ABC) transporter
VSVS12_RS14075	COG0163	prenyltransferase activity
VSVS12_RS14080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VSVS12_RS14085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VSVS12_RS14090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VSVS12_RS14100	COG2105	PFAM AIG2 family protein
VSVS12_RS14105	COG2911	Protein conserved in bacteria
VSVS12_RS14110	COG0729	surface antigen
VSVS12_RS14115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VSVS12_RS14120	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VSVS12_RS14170	COG0432	Pfam Uncharacterised protein family UPF0047
VSVS12_RS14175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VSVS12_RS14200	COG2965	DNA replication, synthesis of RNA primer
VSVS12_RS14205	COG0360	Binds together with S18 to 16S ribosomal RNA
VSVS12_RS14225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VSVS12_RS14230	COG0049	tRNA binding
VSVS12_RS14245	COG2923	Belongs to the DsrF TusC family
VSVS12_RS14255	COG2964	Protein conserved in bacteria
VSVS12_RS14260	COG0545	Peptidyl-prolyl cis-trans isomerase
VSVS12_RS14270	COG2900	Belongs to the SlyX family
VSVS12_RS14275	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VSVS12_RS14280	COG0330	HflC and HflK could
VSVS12_RS14285	COG0330	HflC and HflK could
VSVS12_RS14290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VSVS12_RS14305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VSVS12_RS14310	COG0860	N-Acetylmuramoyl-L-alanine amidase
VSVS12_RS14315	COG0802	atpase or kinase
VSVS12_RS14320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VSVS12_RS14390	COG1162	GTPase activity
VSVS12_RS14395	COG0688	phosphatidylethanolamine metabolic process
VSVS12_RS14400	COG0471	metal ion transport
VSVS12_RS14400	COG3273	potassium ion transport
VSVS12_RS14415	COG4942	peptidase
VSVS12_RS14440	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VSVS12_RS14450	COG0085	RNA polymerase activity
VSVS12_RS14455	COG0222	ribosome binding
VSVS12_RS14460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VSVS12_RS14465	COG0081	regulation of translation
VSVS12_RS14470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VSVS12_RS14475	COG0250	Participates in transcription elongation, termination and antitermination
VSVS12_RS14480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VSVS12_RS14515	COG1072	(Pantothenic acid kinase))
VSVS12_RS14530	COG0149	triose-phosphate isomerase activity
VSVS12_RS14535	COG0534	Mate efflux family protein
VSVS12_RS14540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VSVS12_RS14545	COG1575	Belongs to the MenA family. Type 1 subfamily
VSVS12_RS14555	COG1509	lysine 2,3-aminomutase activity
VSVS12_RS14575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VSVS12_RS14580	COG3678	ATP-independent chaperone mediated protein folding
VSVS12_RS14585	COG0745	RESPONSE REGULATOR receiver
VSVS12_RS14590	COG2205	protein histidine kinase activity
VSVS12_RS14595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VSVS12_RS14605	COG1027	Aspartate ammonia-lyase
VSVS12_RS14610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VSVS12_RS14615	COG4232	protein-disulfide reductase activity
VSVS12_RS14625	COG2095	MarC family integral membrane protein
VSVS12_RS14635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VSVS12_RS14650	COG2814	Major facilitator Superfamily
VSVS12_RS14665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VSVS12_RS14670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VSVS12_RS14675	COG0511	ligase activity, forming carbon-carbon bonds
VSVS12_RS14680	COG0439	Biotin carboxylase
VSVS12_RS14695	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VSVS12_RS14705	COG0789	Transcriptional regulator
VSVS12_RS14710	COG0138	bifunctional purine biosynthesis protein purh
VSVS12_RS14715	COG0151	Belongs to the GarS family
VSVS12_RS14730	COG1253	flavin adenine dinucleotide binding
VSVS12_RS14735	COG3068	Protein conserved in bacteria
VSVS12_RS14740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSVS12_RS14830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VSVS12_RS14840	COG4206	TonB-dependent receptor
VSVS12_RS14845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VSVS12_RS14855	COG1309	transcriptional regulator
VSVS12_RS14890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VSVS12_RS15310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSVS12_RS15495	COG0129	dihydroxy-acid dehydratase activity
VSVS12_RS15720	COG1024	Enoyl-CoA hydratase
VSVS12_RS15720	COG1250	3-hydroxyacyl-CoA dehydrogenase
VSVS12_RS15735	COG2814	Major facilitator Superfamily
VSVS12_RS15955	COG0604	alcohol dehydrogenase
VSVS12_RS16360	COG1295	ribonuclease BN
VSVS12_RS16395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VSVS12_RS16480	COG2183	response to ionizing radiation
VSVS12_RS16485	COG2183	response to ionizing radiation
VSVS12_RS16525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VSVS12_RS16770	COG0527	aspartate kinase activity
VSVS12_RS16770	COG0460	homoserine dehydrogenase
VSVS12_RS16960	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSVS12_RS17040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VSVS12_RS17155	COG0546	phosphoglycolate phosphatase activity
VSVS12_RS18160	COG3835	regulator
VSVS12_RS18365	COG0070	glutamate synthase
VSVS12_RS18365	COG0067	glutamate synthase
VSVS12_RS18365	COG0069	glutamate synthase activity
VSVS12_RS18400	COG0784	Response regulator, receiver
VSVS12_RS18400	COG2198	Histidine kinase
VSVS12_RS18400	COG5002	protein histidine kinase activity
VSVS12_RS18550	COG5001	Diguanylate cyclase
VSVS12_RS19175	COG0772	Belongs to the SEDS family
VSVS12_RS19190	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VSVS12_RS19205	COG0495	leucyl-tRNA aminoacylation
VSVS12_RS19335	COG0622	Phosphoesterase
VSVS12_RS19350	COG0326	Molecular chaperone. Has ATPase activity
VSVS12_RS19520	COG2233	PERMEase
VSVS12_RS19695	COG2056	Na+-H+ antiporter family
VSVS12_RS19935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VSVS12_RS19975	COG2964	Protein conserved in bacteria
VSVS12_RS20085	COG0850	regulation of cytokinetic process
VSVS12_RS20170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VSVS12_RS20695	COG3716	PTS system mannose fructose sorbose family IID component
VSVS12_RS20805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_RS20805	COG2190	(PTS) system
VSVS12_RS20805	COG1263	PTS System
VSVS12_RS20955	COG4166	transmembrane transport
VSVS12_RS21080	COG0243	molybdopterin cofactor binding
VSVS12_RS21105	COG0857	belongs to the CobB CobQ family
VSVS12_RS21105	COG0280	phosphate acetyltransferase
VSVS12_RS21545	COG2267	carboxylic ester hydrolase activity
VSVS12_RS21625	COG3071	HemY protein
VSVS12_RS21900	COG0626	cystathionine gamma-synthase activity
VSVS12_RS22385	COG2937	Belongs to the GPAT DAPAT family