locus-tag	class	description
MTO69_RS00010	COG0592	DNA-directed DNA polymerase activity
MTO69_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MTO69_RS00020	COG0187	DNA topoisomerase II activity
MTO69_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
MTO69_RS00030	COG2182	Extracellular solute-binding protein
MTO69_RS00035	COG3447	MASE1 domain protein
MTO69_RS00035	COG5001	Diguanylate cyclase
MTO69_RS00035	COG5002	protein histidine kinase activity
MTO69_RS00040	COG3977	Valine--pyruvate aminotransferase
MTO69_RS00055	COG2119	membrane
MTO69_RS00080	COG0604	alcohol dehydrogenase
MTO69_RS00090	COG0129	dihydroxy-acid dehydratase activity
MTO69_RS00095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MTO69_RS00100	COG3978	acetolactate synthase activity
MTO69_RS00110	COG0606	chelatase, subunit chli
MTO69_RS00120	COG0204	Acyl-transferase
MTO69_RS00125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MTO69_RS00130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MTO69_RS00140	COG3084	Protein conserved in bacteria
MTO69_RS00150	COG4326	sporulation control protein
MTO69_RS00155	COG1272	protein, Hemolysin III
MTO69_RS00160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MTO69_RS00165	COG0569	domain protein
MTO69_RS00170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MTO69_RS00170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MTO69_RS00180	COG0242	peptide deformylase activity
MTO69_RS00185	COG0758	DNA mediated transformation
MTO69_RS00190	COG2922	Belongs to the Smg family
MTO69_RS00195	COG0551	DNA topoisomerase type I activity
MTO69_RS00200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MTO69_RS00205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MTO69_RS00215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MTO69_RS00225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MTO69_RS00265	COG3706	GGDEF domain
MTO69_RS00270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTO69_RS00270	COG1263	PTS System
MTO69_RS00275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MTO69_RS00285	COG2204	response regulator
MTO69_RS00290	COG3852	Histidine kinase
MTO69_RS00300	COG0174	glutamine synthetase
MTO69_RS00305	COG1217	gtp-binding protein TYPA
MTO69_RS00315	COG1295	ribonuclease BN
MTO69_RS00320	COG1490	D-aminoacyl-tRNA deacylase activity
MTO69_RS00325	COG0456	acetyltransferase
MTO69_RS00335	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MTO69_RS00345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MTO69_RS00350	COG3031	protein transport across the cell outer membrane
MTO69_RS00360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MTO69_RS00365	COG1459	type II secretion system
MTO69_RS00370	COG2165	general secretion pathway protein
MTO69_RS00375	COG2165	general secretion pathway protein
MTO69_RS00380	COG2165	general secretion pathway protein
MTO69_RS00385	COG4795	General secretion pathway protein
MTO69_RS00390	COG3156	type II secretion system protein K
MTO69_RS00395	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MTO69_RS00400	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MTO69_RS00420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MTO69_RS00430	COG2183	response to ionizing radiation
MTO69_RS00440	COG0596	Alpha beta hydrolase
MTO69_RS00455	COG0494	nUDIX hydrolase
MTO69_RS00460	COG1218	3'(2'),5'-bisphosphate nucleotidase
MTO69_RS00465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MTO69_RS00470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MTO69_RS00475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MTO69_RS00480	COG1758	RNA polymerase activity
MTO69_RS00485	COG0194	GDP metabolic process
MTO69_RS00490	COG1561	YicC-like family, N-terminal region
MTO69_RS00495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MTO69_RS00500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MTO69_RS00505	COG1560	Kdo2-lipid A biosynthetic process
MTO69_RS00510	COG1560	Kdo2-lipid A biosynthetic process
MTO69_RS00515	COG1309	transcriptional regulator
MTO69_RS00520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MTO69_RS00525	COG2003	Belongs to the UPF0758 family
MTO69_RS00530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MTO69_RS00550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MTO69_RS00555	COG0859	PFAM glycosyl transferase family 9
MTO69_RS00560	COG0463	Glycosyl transferase, family 2
MTO69_RS00565	COG0859	PFAM glycosyl transferase family 9
MTO69_RS00570	COG3642	lipopolysaccharide core region biosynthetic process
MTO69_RS00595	COG1519	Transferase
MTO69_RS00610	COG0859	PFAM glycosyl transferase family 9
MTO69_RS00655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MTO69_RS00660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MTO69_RS00665	COG0673	inositol 2-dehydrogenase activity
MTO69_RS00675	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MTO69_RS00680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MTO69_RS00685	COG0110	maltose O-acetyltransferase activity
MTO69_RS00695	COG1088	dTDP-glucose 4,6-dehydratase activity
MTO69_RS00730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MTO69_RS00745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MTO69_RS00760	COG1086	Polysaccharide biosynthesis protein
MTO69_RS00785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MTO69_RS00800	COG1122	ATPase activity
MTO69_RS00805	COG4720	Psort location CytoplasmicMembrane, score
MTO69_RS00810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MTO69_RS00815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MTO69_RS00825	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MTO69_RS00825	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MTO69_RS00830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MTO69_RS00880	COG1253	flavin adenine dinucleotide binding
MTO69_RS00895	COG0151	Belongs to the GarS family
MTO69_RS00900	COG0138	bifunctional purine biosynthesis protein purh
MTO69_RS00905	COG0789	Transcriptional regulator
MTO69_RS00910	COG3706	GGDEF domain
MTO69_RS00915	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MTO69_RS00925	COG2264	protein methyltransferase activity
MTO69_RS00930	COG0439	Biotin carboxylase
MTO69_RS00935	COG0511	ligase activity, forming carbon-carbon bonds
MTO69_RS00940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MTO69_RS00945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTO69_RS00960	COG2814	Major facilitator Superfamily
MTO69_RS00965	COG2198	Histidine kinase
MTO69_RS00965	COG0784	Response regulator, receiver
MTO69_RS00965	COG2205	protein histidine kinase activity
MTO69_RS00975	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MTO69_RS00980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MTO69_RS00985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MTO69_RS00990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MTO69_RS01000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MTO69_RS01000	COG0165	Argininosuccinate lyase
MTO69_RS01010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MTO69_RS01010	COG0678	peroxiredoxin activity
MTO69_RS01020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MTO69_RS01045	COG4796	Type ii and iii secretion system protein
MTO69_RS01050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MTO69_RS01055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MTO69_RS01065	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MTO69_RS01070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MTO69_RS01080	COG0180	Tryptophanyl-tRNA synthetase
MTO69_RS01090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MTO69_RS01095	COG2205	protein histidine kinase activity
MTO69_RS01100	COG0745	RESPONSE REGULATOR receiver
MTO69_RS01110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MTO69_RS01115	COG0205	6-phosphofructokinase activity
MTO69_RS01120	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MTO69_RS01125	COG1285	pathogenesis
MTO69_RS01130	COG1509	lysine 2,3-aminomutase activity
MTO69_RS01140	COG1575	Belongs to the MenA family. Type 1 subfamily
MTO69_RS01145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MTO69_RS01150	COG0534	Mate efflux family protein
MTO69_RS01155	COG0149	triose-phosphate isomerase activity
MTO69_RS01170	COG1072	(Pantothenic acid kinase))
MTO69_RS01195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MTO69_RS01200	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MTO69_RS01205	COG0250	Participates in transcription elongation, termination and antitermination
MTO69_RS01220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MTO69_RS01230	COG0085	RNA polymerase activity
MTO69_RS01240	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
MTO69_RS01265	COG4942	peptidase
MTO69_RS01280	COG0840	transmembrane signaling receptor activity
MTO69_RS01285	COG0490	domain, Protein
MTO69_RS01285	COG0471	metal ion transport
MTO69_RS01295	COG1162	GTPase activity
MTO69_RS01355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MTO69_RS01360	COG0802	atpase or kinase
MTO69_RS01370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MTO69_RS01385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MTO69_RS01390	COG0330	HflC and HflK could
MTO69_RS01395	COG0330	HflC and HflK could
MTO69_RS01400	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MTO69_RS01405	COG2900	Belongs to the SlyX family
MTO69_RS01415	COG0545	Peptidyl-prolyl cis-trans isomerase
MTO69_RS01420	COG2964	Protein conserved in bacteria
MTO69_RS01425	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MTO69_RS01430	COG2923	Belongs to the DsrF TusC family
MTO69_RS01450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MTO69_RS01455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MTO69_RS01460	COG2906	2 iron, 2 sulfur cluster binding
MTO69_RS01470	COG0360	Binds together with S18 to 16S ribosomal RNA
MTO69_RS01475	COG2965	DNA replication, synthesis of RNA primer
MTO69_RS01500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MTO69_RS01545	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
MTO69_RS01555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MTO69_RS01560	COG0729	surface antigen
MTO69_RS01565	COG2911	Protein conserved in bacteria
MTO69_RS01570	COG2105	PFAM AIG2 family protein
MTO69_RS01585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MTO69_RS01590	COG0163	prenyltransferase activity
MTO69_RS01595	COG4143	(ABC) transporter
MTO69_RS01600	COG1178	ABC-type Fe3 transport system permease component
MTO69_RS01605	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MTO69_RS01610	COG3028	Belongs to the UPF0307 family
MTO69_RS01615	COG0312	modulator of DNA gyrase
MTO69_RS01625	COG0527	aspartate kinase activity
MTO69_RS01630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MTO69_RS01640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MTO69_RS01650	COG2197	response regulator
MTO69_RS01655	COG0629	single-stranded DNA binding
MTO69_RS01660	COG2200	EAL domain
MTO69_RS01660	COG2199	diguanylate cyclase activity
MTO69_RS01685	COG3409	Peptidoglycan-binding domain 1 protein
MTO69_RS01685	COG3267	Type II secretory pathway component ExeA
MTO69_RS01695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MTO69_RS01700	COG1459	type II secretion system
MTO69_RS01710	COG2165	general secretion pathway protein
MTO69_RS01715	COG2165	general secretion pathway protein
MTO69_RS01745	COG1077	Cell shape determining protein MreB Mrl
MTO69_RS01750	COG1792	Involved in formation and maintenance of cell shape
MTO69_RS01755	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MTO69_RS01760	COG0424	maF-like protein
MTO69_RS01770	COG3164	Protein of unknown function
MTO69_RS01775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MTO69_RS01780	COG0312	modulator of DNA gyrase
MTO69_RS01805	COG0589	response to stress
MTO69_RS01815	COG2358	TRAP transporter, solute receptor (TAXI family
MTO69_RS01820	COG1438	arginine binding
MTO69_RS01825	COG0039	L-malate dehydrogenase activity
MTO69_RS01835	COG0251	oxidation-reduction process
MTO69_RS01840	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MTO69_RS01855	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MTO69_RS01860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MTO69_RS01865	COG0564	pseudouridine synthase activity
MTO69_RS01870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MTO69_RS01880	COG0525	valine-tRNA ligase activity
MTO69_RS01885	COG2927	DNA polymerase III (CHI subunit)
MTO69_RS01895	COG0795	lipopolysaccharide-transporting ATPase activity
MTO69_RS01900	COG0795	lipopolysaccharide-transporting ATPase activity
MTO69_RS01905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MTO69_RS01910	COG3706	GGDEF domain
MTO69_RS01915	COG1546	Belongs to the CinA family
MTO69_RS01920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MTO69_RS01975	COG3630	sodium ion export across plasma membrane
MTO69_RS01980	COG5016	pyruvate
MTO69_RS01980	COG0511	ligase activity, forming carbon-carbon bonds
MTO69_RS01985	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MTO69_RS01995	COG1238	metal cluster binding
MTO69_RS02000	COG0612	Peptidase, M16
MTO69_RS02005	COG2918	glutathione biosynthetic process
MTO69_RS02010	COG1854	S-ribosylhomocysteine lyase activity
MTO69_RS02035	COG3634	alkyl hydroperoxide reductase activity
MTO69_RS02050	COG3437	response regulator, receiver
MTO69_RS02110	COG0473	3-isopropylmalate dehydrogenase activity
MTO69_RS02115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MTO69_RS02130	COG0583	DNA-binding transcription factor activity
MTO69_RS02135	COG1022	Amp-dependent synthetase and ligase
MTO69_RS02140	COG0028	Belongs to the TPP enzyme family
MTO69_RS02145	COG0440	acetolactate synthase activity
MTO69_RS02150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MTO69_RS02155	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MTO69_RS02160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MTO69_RS02175	COG3079	Belongs to the UPF0149 family
MTO69_RS02180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MTO69_RS02185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MTO69_RS02205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MTO69_RS02215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MTO69_RS02220	COG1595	DNA-templated transcription, initiation
MTO69_RS02230	COG3026	antisigma factor binding
MTO69_RS02235	COG3086	response to oxidative stress
MTO69_RS02255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MTO69_RS02260	COG1381	Involved in DNA repair and RecF pathway recombination
MTO69_RS02265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MTO69_RS02270	COG0736	holo-[acyl-carrier-protein] synthase activity
MTO69_RS02285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MTO69_RS02290	COG3956	TIGRFAM MazG family protein
MTO69_RS02295	COG0504	CTP synthase activity
MTO69_RS02300	COG0148	phosphopyruvate hydratase activity
MTO69_RS02305	COG0617	tRNA 3'-terminal CCA addition
MTO69_RS02310	COG3409	Peptidoglycan-binding domain 1 protein
MTO69_RS02310	COG3267	Type II secretory pathway component ExeA
MTO69_RS02320	COG4991	sh3 domain protein
MTO69_RS02325	COG0306	phosphate transporter
MTO69_RS02330	COG1392	Phosphate transport regulator
MTO69_RS02335	COG3025	triphosphatase activity
MTO69_RS02340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MTO69_RS02350	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MTO69_RS02355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MTO69_RS02355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MTO69_RS02360	COG0745	RESPONSE REGULATOR receiver
MTO69_RS02370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MTO69_RS02385	COG0083	homoserine kinase activity
MTO69_RS02390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MTO69_RS02395	COG2860	membrane
MTO69_RS02400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTO69_RS02415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MTO69_RS02440	COG0826	peptidase U32
MTO69_RS02445	COG0826	peptidase U32
MTO69_RS02455	COG3154	lipid carrier protein
MTO69_RS02465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MTO69_RS02480	COG0779	Required for maturation of 30S ribosomal subunits
MTO69_RS02485	COG0195	Participates in both transcription termination and antitermination
MTO69_RS02510	COG0493	'glutamate synthase
MTO69_RS02515	COG0069	glutamate synthase activity
MTO69_RS02515	COG0067	glutamate synthase
MTO69_RS02515	COG0070	glutamate synthase
MTO69_RS02525	COG0067	glutamate synthase
MTO69_RS02525	COG0069	glutamate synthase activity
MTO69_RS02525	COG0070	glutamate synthase
MTO69_RS02530	COG1242	4 iron, 4 sulfur cluster binding
MTO69_RS02535	COG2203	Gaf domain
MTO69_RS02535	COG3706	GGDEF domain
MTO69_RS02535	COG4251	negative regulation of phosphorylation
MTO69_RS02535	COG5001	Diguanylate cyclase
MTO69_RS02540	COG5002	protein histidine kinase activity
MTO69_RS02540	COG2198	Histidine kinase
MTO69_RS02540	COG0784	Response regulator, receiver
MTO69_RS02550	COG1538	Outer membrane efflux protein
MTO69_RS02555	COG0494	nUDIX hydrolase
MTO69_RS02560	COG3151	Protein conserved in bacteria
MTO69_RS02570	COG3150	esterase
MTO69_RS02585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MTO69_RS02590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MTO69_RS02595	COG3105	Protein conserved in bacteria
MTO69_RS02600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MTO69_RS02615	COG0723	plastoquinol--plastocyanin reductase activity
MTO69_RS02620	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MTO69_RS02625	COG2857	Cytochrome c1
MTO69_RS02630	COG0625	glutathione transferase activity
MTO69_RS02635	COG2969	positive regulation of protein catabolic process
MTO69_RS02645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MTO69_RS02650	COG0792	nuclease activity
MTO69_RS02655	COG3107	peptidoglycan biosynthetic process
MTO69_RS02660	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MTO69_RS02675	COG3116	cell division
MTO69_RS02680	COG0768	penicillin binding
MTO69_RS02690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MTO69_RS02705	COG0772	Belongs to the SEDS family
MTO69_RS02710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MTO69_RS02715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MTO69_RS02720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MTO69_RS02725	COG0849	cell division
MTO69_RS02730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MTO69_RS02735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MTO69_RS02750	COG0494	nUDIX hydrolase
MTO69_RS02760	COG0505	Belongs to the CarA family
MTO69_RS02765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MTO69_RS02770	COG0730	response to heat
MTO69_RS02775	COG0583	DNA-binding transcription factor activity
MTO69_RS02780	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
MTO69_RS02785	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MTO69_RS02790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MTO69_RS02805	COG1115	amino acid carrier protein
MTO69_RS02810	COG3022	response to hydroperoxide
MTO69_RS02820	COG0084	hydrolase, TatD family'
MTO69_RS02825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MTO69_RS02840	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MTO69_RS02845	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MTO69_RS02850	COG0813	purine-nucleoside phosphorylase activity
MTO69_RS02865	COG0560	Phosphoserine phosphatase
MTO69_RS02875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MTO69_RS02880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MTO69_RS02885	COG0693	protein deglycase activity
MTO69_RS02890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MTO69_RS02905	COG1595	DNA-templated transcription, initiation
MTO69_RS02915	COG2211	Major facilitator Superfamily
MTO69_RS02930	COG2813	Specifically methylates the guanine in position
MTO69_RS02935	COG0271	Belongs to the BolA IbaG family
MTO69_RS02940	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MTO69_RS02945	COG1805	sodium ion transport
MTO69_RS02950	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MTO69_RS02955	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MTO69_RS02960	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MTO69_RS02965	COG2871	sodium ion transport
MTO69_RS02970	COG1477	protein flavinylation
MTO69_RS02980	COG3706	GGDEF domain
MTO69_RS02985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MTO69_RS02990	COG0514	ATP-dependent DNA helicase (RecQ)
MTO69_RS02995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MTO69_RS03005	COG0733	neurotransmitter:sodium symporter activity
MTO69_RS03015	COG0189	ligase activity
MTO69_RS03020	COG0189	ligase activity
MTO69_RS03020	COG4067	protein conserved in archaea
MTO69_RS03025	COG2195	Cleaves the N-terminal amino acid of tripeptides
MTO69_RS03030	COG2252	PERMEase
MTO69_RS03035	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MTO69_RS03040	COG1073	alpha beta
MTO69_RS03050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MTO69_RS03055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MTO69_RS03060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MTO69_RS03065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MTO69_RS03065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MTO69_RS03085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MTO69_RS03090	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MTO69_RS03095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MTO69_RS03110	COG0024	Methionine aminopeptidase
MTO69_RS03120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MTO69_RS03125	COG0528	UMP kinase activity
MTO69_RS03130	COG0233	cytoplasmic translational termination
MTO69_RS03135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MTO69_RS03140	COG0575	Belongs to the CDS family
MTO69_RS03145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MTO69_RS03150	COG0750	zinc metalloprotease
MTO69_RS03155	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MTO69_RS03160	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
MTO69_RS03165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MTO69_RS03190	COG0587	DNA-directed DNA polymerase activity
MTO69_RS03210	COG0347	Belongs to the P(II) protein family
MTO69_RS03215	COG3021	interspecies interaction between organisms
MTO69_RS03225	COG0741	lytic transglycosylase activity
MTO69_RS03225	COG1388	LysM domain
MTO69_RS03230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MTO69_RS03235	COG2226	methyltransferase
MTO69_RS03240	COG0328	RNA-DNA hybrid ribonuclease activity
MTO69_RS03255	COG1960	acyl-CoA dehydrogenase activity
MTO69_RS03260	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MTO69_RS03265	COG0121	glutamine amidotransferase
MTO69_RS03275	COG1720	tRNA m6t6A37 methyltransferase activity
MTO69_RS03280	COG0254	rRNA binding
MTO69_RS03290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MTO69_RS03300	COG1464	Belongs to the NlpA lipoprotein family
MTO69_RS03305	COG2011	ABC-type metal ion transport system permease component
MTO69_RS03310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MTO69_RS03315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MTO69_RS03330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTO69_RS03330	COG1263	PTS System
MTO69_RS03335	COG0366	Alpha amylase catalytic
MTO69_RS03365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MTO69_RS03375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MTO69_RS03395	COG2921	Belongs to the UPF0250 family
MTO69_RS03400	COG1686	Belongs to the peptidase S11 family
MTO69_RS03405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MTO69_RS03410	COG0772	Belongs to the SEDS family
MTO69_RS03415	COG0768	penicillin binding
MTO69_RS03420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MTO69_RS03425	COG0799	negative regulation of ribosome biogenesis
MTO69_RS03430	COG1466	dna polymerase III delta subunit
MTO69_RS03435	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MTO69_RS03440	COG0495	leucyl-tRNA aminoacylation
MTO69_RS03445	COG2888	peptidyl-tyrosine sulfation
MTO69_RS03450	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MTO69_RS03455	COG4535	Mg2 and Co2 transporter CorC
MTO69_RS03465	COG1702	phosphate starvation-inducible protein PhoH
MTO69_RS03470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MTO69_RS03475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MTO69_RS03480	COG2190	(PTS) system
MTO69_RS03485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MTO69_RS03490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTO69_RS03495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MTO69_RS03500	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
MTO69_RS03505	COG3115	cell septum assembly
MTO69_RS03510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MTO69_RS03530	COG1585	Membrane protein implicated in regulation of membrane protease activity
MTO69_RS03535	COG0330	HflC and HflK could
MTO69_RS03540	COG3118	belongs to the thioredoxin family
MTO69_RS03545	COG0300	oxidoreductase activity
MTO69_RS03550	COG1090	epimerase
MTO69_RS03575	COG0622	Phosphoesterase
MTO69_RS03595	COG3710	Transcriptional regulator
MTO69_RS03600	COG0326	Molecular chaperone. Has ATPase activity
MTO69_RS03610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MTO69_RS03625	COG2217	Heavy metal translocating P-type atpase
MTO69_RS03625	COG2608	mercury ion transmembrane transporter activity
MTO69_RS03680	COG2747	anti-sigma28 factor FlgM
MTO69_RS03690	COG0784	Response regulator, receiver
MTO69_RS03690	COG0835	chemotaxis
MTO69_RS03695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MTO69_RS03700	COG1815	bacterial-type flagellum-dependent cell motility
MTO69_RS03715	COG1749	Flagellar hook protein flgE
MTO69_RS03720	COG4787	bacterial-type flagellum-dependent cell motility
MTO69_RS03730	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MTO69_RS03735	COG1706	bacterial-type flagellum-dependent cell motility
MTO69_RS03740	COG1705	Flagellar rod assembly protein muramidase FlgJ
MTO69_RS03740	COG3951	Flagellar rod assembly protein muramidase FlgJ
MTO69_RS03755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MTO69_RS03875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MTO69_RS03880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MTO69_RS03885	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MTO69_RS03890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MTO69_RS03895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MTO69_RS03900	COG2890	protein-(glutamine-N5) methyltransferase activity
MTO69_RS03910	COG2912	Transglutaminase-like superfamily
MTO69_RS03915	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MTO69_RS03925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MTO69_RS03930	COG2233	PERMEase
MTO69_RS03950	COG1393	Belongs to the ArsC family
MTO69_RS03955	COG4783	chaperone-mediated protein folding
MTO69_RS03970	COG0840	transmembrane signaling receptor activity
MTO69_RS03975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MTO69_RS03980	COG2716	regulation of RNA biosynthetic process
MTO69_RS03985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MTO69_RS03990	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MTO69_RS03995	COG2056	Na+-H+ antiporter family
MTO69_RS04015	COG0346	lactoylglutathione lyase activity
MTO69_RS04020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MTO69_RS04025	COG4660	Part of a membrane complex involved in electron transport
MTO69_RS04030	COG4659	FMN binding
MTO69_RS04035	COG4658	electron transport chain
MTO69_RS04040	COG4656	Part of a membrane complex involved in electron transport
MTO69_RS04045	COG2878	Part of a membrane complex involved in electron transport
MTO69_RS04050	COG4657	Part of a membrane complex involved in electron transport
MTO69_RS04060	COG0556	nucleotide-excision repair
MTO69_RS04070	COG2198	Histidine kinase
MTO69_RS04075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MTO69_RS04080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MTO69_RS04085	COG0521	Mo-molybdopterin cofactor biosynthetic process
MTO69_RS04090	COG0315	cyclic pyranopterin monophosphate synthase activity
MTO69_RS04095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MTO69_RS04100	COG0314	molybdopterin synthase activity
MTO69_RS04105	COG3706	GGDEF domain
MTO69_RS04115	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MTO69_RS04115	COG0617	tRNA 3'-terminal CCA addition
MTO69_RS04115	COG0517	IMP dehydrogenase activity
MTO69_RS04145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTO69_RS04145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTO69_RS04155	COG0572	uridine kinase
MTO69_RS04165	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
MTO69_RS04170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MTO69_RS04190	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MTO69_RS04195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MTO69_RS04205	COG0123	including yeast histone deacetylase and acetoin utilization protein
MTO69_RS04215	COG3706	GGDEF domain
MTO69_RS04230	COG3083	sulfuric ester hydrolase activity
MTO69_RS04240	COG3081	Nucleoid-associated protein
MTO69_RS04250	COG1757	Na H antiporter
MTO69_RS04255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MTO69_RS04265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MTO69_RS04270	COG2095	MarC family integral membrane protein
MTO69_RS04275	COG1454	alcohol dehydrogenase
MTO69_RS04275	COG1012	belongs to the aldehyde dehydrogenase family
MTO69_RS04280	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MTO69_RS04285	COG2894	cell division
MTO69_RS04290	COG0850	regulation of cytokinetic process
MTO69_RS04295	COG3100	YcgL domain-containing protein
MTO69_RS04300	COG2951	lytic endotransglycosylase activity
MTO69_RS04320	COG0840	transmembrane signaling receptor activity
MTO69_RS04325	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MTO69_RS04345	COG1175	transmembrane transport
MTO69_RS04355	COG3842	ATPase activity
MTO69_RS04360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MTO69_RS04365	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MTO69_RS04370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MTO69_RS04375	COG2204	response regulator
MTO69_RS04385	COG0544	peptidyl-prolyl cis-trans isomerase activity
MTO69_RS04395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MTO69_RS04400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MTO69_RS04405	COG0776	regulation of translation
MTO69_RS04410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MTO69_RS04415	COG1555	photosystem II stabilization
MTO69_RS04420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MTO69_RS04425	COG0539	negative regulation of cytoplasmic translation
MTO69_RS04435	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
MTO69_RS04440	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MTO69_RS04475	COG4120	Belongs to the binding-protein-dependent transport system permease family
MTO69_RS04485	COG3706	GGDEF domain
MTO69_RS04490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MTO69_RS04495	COG0653	protein targeting
MTO69_RS04505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MTO69_RS04520	COG0252	asparaginase activity
MTO69_RS04525	COG0616	signal peptide processing
MTO69_RS04530	COG1902	pentaerythritol trinitrate reductase activity
MTO69_RS04530	COG0446	pyridine nucleotide-disulphide oxidoreductase
MTO69_RS04535	COG0788	formyltetrahydrofolate deformylase activity
MTO69_RS04545	COG1199	ATP-dependent helicase activity
MTO69_RS04550	COG1214	PFAM Peptidase M22, glycoprotease
MTO69_RS04565	COG0596	Alpha beta hydrolase
MTO69_RS04570	COG0318	PFAM AMP-dependent synthetase and ligase
MTO69_RS04575	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MTO69_RS04580	COG0659	secondary active sulfate transmembrane transporter activity
MTO69_RS04585	COG1530	ribonuclease E activity
MTO69_RS04590	COG0564	pseudouridine synthase activity
MTO69_RS04595	COG0424	maF-like protein
MTO69_RS04600	COG1399	metal-binding, possibly nucleic acid-binding protein
MTO69_RS04605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MTO69_RS04615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MTO69_RS04640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MTO69_RS04645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MTO69_RS04650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MTO69_RS04655	COG0470	DNA polymerase III
MTO69_RS04660	COG0084	hydrolase, TatD family'
MTO69_RS04665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTO69_RS04665	COG1263	PTS System
MTO69_RS04685	COG4667	esterase of the alpha-beta hydrolase superfamily
MTO69_RS04690	COG0469	pyruvate kinase activity
MTO69_RS04695	COG1940	carbohydrate kinase activity
MTO69_RS04700	COG0835	chemotaxis
MTO69_RS04700	COG0784	Response regulator, receiver
MTO69_RS04720	COG1028	Short-chain dehydrogenase reductase Sdr
MTO69_RS04725	COG0616	signal peptide processing
MTO69_RS04730	COG0583	DNA-binding transcription factor activity
MTO69_RS04735	COG2249	NAD(P)H dehydrogenase (quinone) activity
MTO69_RS04740	COG0513	Belongs to the DEAD box helicase family
MTO69_RS04755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MTO69_RS04760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MTO69_RS04765	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MTO69_RS04770	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MTO69_RS04775	COG0436	Aminotransferase
MTO69_RS04780	COG1169	isochorismate synthase
MTO69_RS04785	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MTO69_RS04790	COG0596	Alpha beta hydrolase
MTO69_RS04795	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MTO69_RS04810	COG3287	FIST C domain
MTO69_RS04810	COG2200	EAL domain
MTO69_RS04810	COG2199	diguanylate cyclase activity
MTO69_RS04820	COG2855	membrane
MTO69_RS04825	COG0477	Major facilitator Superfamily
MTO69_RS04850	COG1522	sequence-specific DNA binding
MTO69_RS04855	COG1454	alcohol dehydrogenase
MTO69_RS04860	COG1946	Acyl-CoA thioesterase
MTO69_RS04865	COG3126	Type III secretion system lipoprotein chaperone (YscW)
MTO69_RS04880	COG5001	Diguanylate cyclase
MTO69_RS04880	COG3300	MHYT domain
MTO69_RS04900	COG2205	protein histidine kinase activity
MTO69_RS04900	COG0784	Response regulator, receiver
MTO69_RS04905	COG3226	Transcriptional regulator
MTO69_RS04910	COG0702	epimerase
MTO69_RS04915	COG3706	GGDEF domain
MTO69_RS04930	COG0601	transmembrane transport
MTO69_RS04935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO69_RS04940	COG0444	Belongs to the ABC transporter superfamily
MTO69_RS04950	COG0435	Glutathione S-transferase
MTO69_RS04955	COG3174	membrane
MTO69_RS04960	COG0280	phosphate acetyltransferase
MTO69_RS04960	COG0857	belongs to the CobB CobQ family
MTO69_RS04970	COG3092	negative regulation of chromosome organization
MTO69_RS04975	COG0686	Belongs to the AlaDH PNT family
MTO69_RS04980	COG1522	sequence-specific DNA binding
MTO69_RS04985	COG1674	ftsk spoiiie
MTO69_RS05000	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MTO69_RS05005	COG2186	Transcriptional regulator
MTO69_RS05020	COG0537	adenosine 5'-monophosphoramidase activity
MTO69_RS05045	COG3150	esterase
MTO69_RS05050	COG1252	NADH dehydrogenase
MTO69_RS05065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MTO69_RS05075	COG4591	ABC-type transport system involved in lipoprotein release permease component
MTO69_RS05080	COG1136	(ABC) transporter
MTO69_RS05085	COG4591	ABC-type transport system involved in lipoprotein release permease component
MTO69_RS05095	COG0658	competence protein
MTO69_RS05095	COG2333	competence protein COMEC
MTO69_RS05100	COG1132	(ABC) transporter
MTO69_RS05105	COG1663	tetraacyldisaccharide 4'-kinase activity
MTO69_RS05110	COG2835	tetraacyldisaccharide 4'-kinase activity
MTO69_RS05115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MTO69_RS05120	COG2719	SpoVR family
MTO69_RS05125	COG2718	Belongs to the UPF0229 family
MTO69_RS05130	COG2766	serine protein kinase
MTO69_RS05135	COG0840	transmembrane signaling receptor activity
MTO69_RS05140	COG3013	Belongs to the UPF0304 family
MTO69_RS05150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MTO69_RS05165	COG1882	Formate acetyltransferase
MTO69_RS05190	COG4160	amino acid transport
MTO69_RS05200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MTO69_RS05205	COG1454	alcohol dehydrogenase
MTO69_RS05210	COG1737	Transcriptional regulator
MTO69_RS05215	COG0076	glutamate decarboxylase activity
MTO69_RS05225	COG2431	L-lysine efflux transmembrane transporter activity
MTO69_RS05235	COG3070	regulator of competence-specific genes
MTO69_RS05250	COG4191	Histidine kinase
MTO69_RS05250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTO69_RS05260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MTO69_RS05265	COG1032	radical SAM domain protein
MTO69_RS05295	COG0583	DNA-binding transcription factor activity
MTO69_RS05300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MTO69_RS05305	COG1764	response to oxidative stress
MTO69_RS05310	COG1846	Transcriptional regulator
MTO69_RS05320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTO69_RS05335	COG0243	molybdopterin cofactor binding
MTO69_RS05340	COG3005	denitrification pathway
MTO69_RS05345	COG3040	lipid binding
MTO69_RS05350	COG0443	Heat shock 70 kDa protein
MTO69_RS05370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MTO69_RS05380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MTO69_RS05385	COG4191	Histidine kinase
MTO69_RS05415	COG1643	Atp-dependent helicase
MTO69_RS05430	COG1132	(ABC) transporter
MTO69_RS05455	COG2067	long-chain fatty acid transport protein
MTO69_RS05465	COG0583	DNA-binding transcription factor activity
MTO69_RS05470	COG1301	dicarboxylic acid transport
MTO69_RS05475	COG0159	tryptophan synthase activity
MTO69_RS05480	COG0133	tryptophan synthase activity
MTO69_RS05485	COG0135	phosphoribosylanthranilate isomerase activity
MTO69_RS05485	COG0134	indole-3-glycerol-phosphate synthase activity
MTO69_RS05490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MTO69_RS05495	COG0512	Glutamine amidotransferase of anthranilate synthase
MTO69_RS05500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MTO69_RS05515	COG0009	L-threonylcarbamoyladenylate synthase
MTO69_RS05520	COG1187	pseudouridine synthase activity
MTO69_RS05525	COG4251	negative regulation of phosphorylation
MTO69_RS05525	COG2203	Gaf domain
MTO69_RS05525	COG3706	GGDEF domain
MTO69_RS05525	COG5001	Diguanylate cyclase
MTO69_RS05530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MTO69_RS05535	COG4988	ABC transporter
MTO69_RS05540	COG0492	ferredoxin-NADP+ reductase activity
MTO69_RS05550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MTO69_RS05565	COG2949	membrane
MTO69_RS05575	COG0281	malic enzyme
MTO69_RS05580	COG1643	Atp-dependent helicase
MTO69_RS05590	COG1448	Aminotransferase
MTO69_RS05595	COG2770	Histidine kinase
MTO69_RS05595	COG3437	response regulator, receiver
MTO69_RS05605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTO69_RS05620	COG0017	Asparaginyl-tRNA synthetase
MTO69_RS05625	COG0840	transmembrane signaling receptor activity
MTO69_RS05630	COG0720	synthase
MTO69_RS05635	COG1760	l-serine dehydratase
MTO69_RS05640	COG0814	amino acid
MTO69_RS05645	COG0494	nUDIX hydrolase
MTO69_RS05655	COG0784	Response regulator, receiver
MTO69_RS05655	COG2205	protein histidine kinase activity
MTO69_RS05675	COG3106	COG3106 Predicted ATPase
MTO69_RS05680	COG3768	UPF0283 membrane protein
MTO69_RS05690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTO69_RS05710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MTO69_RS05715	COG0583	DNA-binding transcription factor activity
MTO69_RS05720	COG2814	Major facilitator Superfamily
MTO69_RS05750	COG3108	Peptidase M15
MTO69_RS05755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MTO69_RS05770	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MTO69_RS05800	COG4667	esterase of the alpha-beta hydrolase superfamily
MTO69_RS05810	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MTO69_RS05825	COG2267	carboxylic ester hydrolase activity
MTO69_RS05840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTO69_RS05880	COG3501	Rhs element vgr protein
MTO69_RS05915	COG1061	Type III restriction enzyme res subunit
MTO69_RS05925	COG2814	Major facilitator Superfamily
MTO69_RS05935	COG0702	epimerase
MTO69_RS05940	COG0534	Mate efflux family protein
MTO69_RS05945	COG1136	(ABC) transporter
MTO69_RS05950	COG0577	efflux transmembrane transporter activity
MTO69_RS05960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MTO69_RS05990	COG0019	diaminopimelate decarboxylase activity
MTO69_RS06015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MTO69_RS06020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MTO69_RS06025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MTO69_RS06035	COG0531	amino acid
MTO69_RS06040	COG3501	Rhs element vgr protein
MTO69_RS06045	COG4104	PAAR repeat-containing protein
MTO69_RS06070	COG0840	transmembrane signaling receptor activity
MTO69_RS06075	COG1328	CTP reductase activity
MTO69_RS06080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MTO69_RS06095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MTO69_RS06105	COG0584	glycerophosphoryl diester phosphodiesterase
MTO69_RS06110	COG0039	L-malate dehydrogenase activity
MTO69_RS06125	COG0811	peptide transport
MTO69_RS06130	COG0811	peptide transport
MTO69_RS06135	COG0848	biopolymer transport protein
MTO69_RS06155	COG3290	protein histidine kinase activity
MTO69_RS06160	COG4565	transcriptional regulatory protein
MTO69_RS06175	COG2199	diguanylate cyclase activity
MTO69_RS06180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MTO69_RS06190	COG2116	formate transmembrane transporter activity
MTO69_RS06210	COG0745	RESPONSE REGULATOR receiver
MTO69_RS06215	COG2205	protein histidine kinase activity
MTO69_RS06220	COG3713	MltA-interacting MipA family protein
MTO69_RS06315	COG5001	Diguanylate cyclase
MTO69_RS06330	COG5001	Diguanylate cyclase
MTO69_RS06335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MTO69_RS06365	COG0840	transmembrane signaling receptor activity
MTO69_RS06370	COG2169	Transcriptional regulator
MTO69_RS06380	COG0835	chemotaxis
MTO69_RS06380	COG0784	Response regulator, receiver
MTO69_RS06450	COG4974	Belongs to the 'phage' integrase family
MTO69_RS06495	COG2188	Transcriptional regulator
MTO69_RS06500	COG1486	melibiose metabolic process
MTO69_RS06505	COG1263	PTS System
MTO69_RS06505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTO69_RS06520	COG2202	Pas domain
MTO69_RS06520	COG2200	EAL domain
MTO69_RS06520	COG2199	diguanylate cyclase activity
MTO69_RS06530	COG5001	Diguanylate cyclase
MTO69_RS06530	COG3300	MHYT domain
MTO69_RS06540	COG0835	chemotaxis
MTO69_RS06540	COG0784	Response regulator, receiver
MTO69_RS06560	COG3706	GGDEF domain
MTO69_RS06565	COG0840	transmembrane signaling receptor activity
MTO69_RS06575	COG0840	transmembrane signaling receptor activity
MTO69_RS06580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MTO69_RS06585	COG1288	antiporter activity
MTO69_RS06615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MTO69_RS06625	COG0297	glycogen (starch) synthase activity
MTO69_RS06640	COG0110	maltose O-acetyltransferase activity
MTO69_RS06660	COG0438	transferase activity, transferring glycosyl groups
MTO69_RS06710	COG0534	Mate efflux family protein
MTO69_RS06715	COG0307	riboflavin synthase, alpha
MTO69_RS06725	COG3001	Fructosamine kinase
MTO69_RS06735	COG0791	NLP P60 protein
MTO69_RS06740	COG0840	transmembrane signaling receptor activity
MTO69_RS06750	COG3148	PFAM DTW domain containing protein
MTO69_RS06755	COG1940	carbohydrate kinase activity
MTO69_RS06760	COG2199	diguanylate cyclase activity
MTO69_RS06760	COG2202	Pas domain
MTO69_RS06760	COG2200	EAL domain
MTO69_RS06770	COG0303	'Molybdopterin
MTO69_RS06775	COG0746	molybdenum cofactor guanylyltransferase activity
MTO69_RS06780	COG3842	ATPase activity
MTO69_RS06785	COG4662	Binding-protein-dependent transport system inner membrane component
MTO69_RS06795	COG2204	response regulator
MTO69_RS06800	COG4191	Histidine kinase
MTO69_RS06805	COG0488	(ABC) transporter
MTO69_RS06810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MTO69_RS06840	COG0243	molybdopterin cofactor binding
MTO69_RS06840	COG3383	formate dehydrogenase (NAD+) activity
MTO69_RS06845	COG0437	4 iron, 4 sulfur cluster binding
MTO69_RS06860	COG0004	ammonium transporteR
MTO69_RS06865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MTO69_RS06880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MTO69_RS06885	COG1177	transmembrane transport
MTO69_RS06890	COG1176	ABC-type spermidine putrescine transport system, permease component I
MTO69_RS06895	COG3842	ATPase activity
MTO69_RS06920	COG0589	response to stress
MTO69_RS06925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MTO69_RS06940	COG2217	Heavy metal translocating P-type atpase
MTO69_RS06950	COG2010	Cytochrome c
MTO69_RS06965	COG3278	Belongs to the heme-copper respiratory oxidase family
MTO69_RS06980	COG0784	Response regulator, receiver
MTO69_RS06980	COG2205	protein histidine kinase activity
MTO69_RS06995	COG3120	sequence-specific DNA binding
MTO69_RS07000	COG1067	ATP-dependent peptidase activity
MTO69_RS07005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MTO69_RS07020	COG0488	(ABC) transporter
MTO69_RS07030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MTO69_RS07030	COG0116	Belongs to the methyltransferase superfamily
MTO69_RS07045	COG2902	Dehydrogenase
MTO69_RS07055	COG0308	aminopeptidase N
MTO69_RS07070	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
MTO69_RS07075	COG1956	GAF domain-containing protein
MTO69_RS07080	COG1132	(ABC) transporter
MTO69_RS07085	COG2995	paraquat-inducible protein a
MTO69_RS07090	COG3008	intermembrane lipid transfer
MTO69_RS07115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MTO69_RS07120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MTO69_RS07125	COG1666	GTP binding
MTO69_RS07130	COG1648	precorrin-2 dehydrogenase activity
MTO69_RS07130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MTO69_RS07135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTO69_RS07140	COG4597	amino acid ABC transporter
MTO69_RS07145	COG0765	amino acid transport
MTO69_RS07150	COG1126	abc transporter atp-binding protein
MTO69_RS07155	COG0670	Belongs to the BI1 family
MTO69_RS07160	COG2920	part of a sulfur-relay system
MTO69_RS07165	COG1254	Belongs to the acylphosphatase family
MTO69_RS07170	COG0840	transmembrane signaling receptor activity
MTO69_RS07175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MTO69_RS07190	COG2885	chlorophyll binding
MTO69_RS07200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MTO69_RS07205	COG0602	queuosine metabolic process
MTO69_RS07210	COG0561	phosphatase activity
MTO69_RS07215	COG1051	belongs to the nudix hydrolase family
MTO69_RS07240	COG0372	Belongs to the citrate synthase family
MTO69_RS07245	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MTO69_RS07280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MTO69_RS07295	COG5001	Diguanylate cyclase
MTO69_RS07305	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MTO69_RS07325	COG1451	nucleotide metabolic process
MTO69_RS07335	COG0784	Response regulator, receiver
MTO69_RS07335	COG5002	protein histidine kinase activity
MTO69_RS07345	COG0583	DNA-binding transcription factor activity
MTO69_RS07365	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
MTO69_RS07395	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MTO69_RS07400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MTO69_RS07405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MTO69_RS07410	COG0702	epimerase
MTO69_RS07420	COG2925	Exonuclease
MTO69_RS07425	COG1380	Effector of murein hydrolase LrgA
MTO69_RS07430	COG1346	cytolysis
MTO69_RS07435	COG0295	cytidine deaminase activity
MTO69_RS07450	COG0500	methyltransferase
MTO69_RS07460	COG2188	Transcriptional regulator
MTO69_RS07465	COG1228	amidohydrolase
MTO69_RS07470	COG0010	Belongs to the arginase family
MTO69_RS07475	COG2986	histidine ammonia-lyase
MTO69_RS07480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MTO69_RS07500	COG1105	Belongs to the carbohydrate kinase PfkB family
MTO69_RS07505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MTO69_RS07505	COG0517	IMP dehydrogenase activity
MTO69_RS07510	COG4702	Belongs to the UPF0303 family
MTO69_RS07515	COG0673	inositol 2-dehydrogenase activity
MTO69_RS07520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTO69_RS07520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MTO69_RS07520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTO69_RS07525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MTO69_RS07530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MTO69_RS07535	COG1882	Formate acetyltransferase
MTO69_RS07540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MTO69_RS07550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MTO69_RS07555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MTO69_RS07560	COG2207	Transcriptional regulator
MTO69_RS07580	COG0277	FAD linked oxidase domain protein
MTO69_RS07580	COG0247	lactate metabolic process
MTO69_RS07595	COG2885	chlorophyll binding
MTO69_RS07610	COG0625	glutathione transferase activity
MTO69_RS07620	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MTO69_RS07630	COG2195	Cleaves the N-terminal amino acid of tripeptides
MTO69_RS07655	COG1115	amino acid carrier protein
MTO69_RS07660	COG1280	lysine exporter protein (LysE YggA)
MTO69_RS07665	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MTO69_RS07700	COG3706	GGDEF domain
MTO69_RS07715	COG0384	phenazine biosynthesis protein PhzF
MTO69_RS07735	COG0583	DNA-binding transcription factor activity
MTO69_RS07740	COG0534	Mate efflux family protein
MTO69_RS07755	COG0840	transmembrane signaling receptor activity
MTO69_RS07770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTO69_RS07775	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MTO69_RS07780	COG1621	beta-fructofuranosidase activity
MTO69_RS07790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTO69_RS07790	COG1263	PTS System
MTO69_RS07795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTO69_RS07795	COG0072	phenylalanine-tRNA ligase activity
MTO69_RS07810	COG3706	GGDEF domain
MTO69_RS07815	COG2133	pyrroloquinoline quinone binding
MTO69_RS07820	COG5001	Diguanylate cyclase
MTO69_RS07820	COG4251	negative regulation of phosphorylation
MTO69_RS07820	COG3706	GGDEF domain
MTO69_RS07820	COG2203	Gaf domain
MTO69_RS07855	COG0322	excinuclease ABC activity
MTO69_RS07860	COG2197	response regulator
MTO69_RS07865	COG0417	DNA replication proofreading
MTO69_RS07870	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MTO69_RS07890	COG0776	regulation of translation
MTO69_RS07915	COG2350	Protein conserved in bacteria
MTO69_RS07935	COG3313	Fe-S protein
MTO69_RS07960	COG0493	'glutamate synthase
MTO69_RS07970	COG0398	Pfam SNARE associated Golgi protein
MTO69_RS07975	COG4134	Bacterial extracellular solute-binding protein
MTO69_RS07980	COG4135	transport system, permease component
MTO69_RS07985	COG4136	ATPase activity
MTO69_RS07990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MTO69_RS08000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MTO69_RS08005	COG0564	pseudouridine synthase activity
MTO69_RS08015	COG0733	neurotransmitter:sodium symporter activity
MTO69_RS08025	COG0626	cystathionine gamma-synthase activity
MTO69_RS08030	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MTO69_RS08040	COG0519	Catalyzes the synthesis of GMP from XMP
MTO69_RS08050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MTO69_RS08070	COG1842	Phage shock protein A
MTO69_RS08075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MTO69_RS08090	COG4171	peptide transport system, permease
MTO69_RS08100	COG4172	Belongs to the ABC transporter superfamily
MTO69_RS08115	COG1227	inorganic diphosphatase activity
MTO69_RS08125	COG0527	aspartate kinase activity
MTO69_RS08130	COG0662	Cupin 2, conserved barrel domain protein
MTO69_RS08135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MTO69_RS08140	COG0456	acetyltransferase
MTO69_RS08150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MTO69_RS08150	COG0140	phosphoribosyl-ATP diphosphatase activity
MTO69_RS08160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MTO69_RS08165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MTO69_RS08170	COG0131	Imidazoleglycerol-phosphate dehydratase
MTO69_RS08170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MTO69_RS08175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MTO69_RS08180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MTO69_RS08190	COG1757	Na H antiporter
MTO69_RS08195	COG2916	Histone family protein nucleoid-structuring protein H-NS
MTO69_RS08200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTO69_RS08210	COG0482	sulfurtransferase activity
MTO69_RS08215	COG2915	High frequency lysogenization protein hflD homolog
MTO69_RS08220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MTO69_RS08230	COG2268	Band 7 protein
MTO69_RS08240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MTO69_RS08255	COG4221	oxidoreductase activity
MTO69_RS08265	COG0501	Belongs to the peptidase M48B family
MTO69_RS08275	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MTO69_RS08280	COG2226	methyltransferase
MTO69_RS08280	COG1073	alpha beta
MTO69_RS08285	COG0156	8-amino-7-oxononanoate synthase activity
MTO69_RS08290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MTO69_RS08295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MTO69_RS08300	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MTO69_RS08305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MTO69_RS08310	COG1199	ATP-dependent helicase activity
MTO69_RS08315	COG0730	response to heat
MTO69_RS08320	COG3923	Primosomal replication protein n
MTO69_RS08330	COG0840	transmembrane signaling receptor activity
MTO69_RS08335	COG0708	Exodeoxyribonuclease III
MTO69_RS08345	COG1960	acyl-CoA dehydrogenase activity
MTO69_RS08365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MTO69_RS08375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MTO69_RS08425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MTO69_RS08435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MTO69_RS08440	COG0602	queuosine metabolic process
MTO69_RS08495	COG0582	viral genome integration into host DNA
MTO69_RS08545	COG0784	Response regulator, receiver
MTO69_RS08545	COG5002	protein histidine kinase activity
MTO69_RS08560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MTO69_RS08565	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MTO69_RS08570	COG2885	chlorophyll binding
MTO69_RS08575	COG0823	Involved in the tonB-independent uptake of proteins
MTO69_RS08590	COG0811	peptide transport
MTO69_RS08595	COG0824	Thioesterase
MTO69_RS08605	COG4890	Cyd operon protein YbgT
MTO69_RS08610	COG1294	oxidase, subunit
MTO69_RS08615	COG1271	oxidase subunit
MTO69_RS08620	COG2255	four-way junction helicase activity
MTO69_RS08625	COG0632	four-way junction helicase activity
MTO69_RS08630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MTO69_RS08645	COG0243	molybdopterin cofactor binding
MTO69_RS08650	COG3005	denitrification pathway
MTO69_RS08655	COG4459	periplasmic nitrate reductase
MTO69_RS08660	COG0390	transport system, permease component
MTO69_RS08665	COG2116	formate transmembrane transporter activity
MTO69_RS08690	COG0542	response to heat
MTO69_RS08695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MTO69_RS08700	COG1278	Cold shock
MTO69_RS08710	COG1187	pseudouridine synthase activity
MTO69_RS08720	COG1801	Protein of unknown function DUF72
MTO69_RS08725	COG4106	trans-aconitate 2-methyltransferase activity
MTO69_RS08735	COG0189	ligase activity
MTO69_RS08735	COG4067	protein conserved in archaea
MTO69_RS08755	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MTO69_RS08760	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
MTO69_RS08765	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
MTO69_RS08770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MTO69_RS08775	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MTO69_RS08780	COG0745	RESPONSE REGULATOR receiver
MTO69_RS08790	COG1609	Transcriptional regulator
MTO69_RS08795	COG3070	regulator of competence-specific genes
MTO69_RS08815	COG0297	glycogen (starch) synthase activity
MTO69_RS08820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MTO69_RS08825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MTO69_RS08845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MTO69_RS08850	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MTO69_RS08855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MTO69_RS08860	COG1435	thymidine kinase activity
MTO69_RS08865	COG0215	cysteine-tRNA ligase activity
MTO69_RS08870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MTO69_RS08875	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MTO69_RS08880	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MTO69_RS08885	COG3012	SEC-C Motif Domain Protein
MTO69_RS08890	COG3139	Protein of unknown function (DUF1315)
MTO69_RS08900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MTO69_RS08905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MTO69_RS08915	COG2226	methyltransferase
MTO69_RS08930	COG1785	Belongs to the alkaline phosphatase family
MTO69_RS08935	COG0668	transmembrane transport
MTO69_RS08940	COG2983	Belongs to the UPF0260 family
MTO69_RS08965	COG3829	transcription factor binding
MTO69_RS09035	COG0745	RESPONSE REGULATOR receiver
MTO69_RS09040	COG2205	protein histidine kinase activity
MTO69_RS09050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MTO69_RS09065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MTO69_RS09070	COG2832	Protein of unknown function (DUF454)
MTO69_RS09075	COG0745	RESPONSE REGULATOR receiver
MTO69_RS09080	COG0583	DNA-binding transcription factor activity
MTO69_RS09085	COG0778	Nitroreductase
MTO69_RS09090	COG1024	Enoyl-CoA hydratase
MTO69_RS09090	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTO69_RS09095	COG0183	Belongs to the thiolase family
MTO69_RS09110	COG2067	long-chain fatty acid transport protein
MTO69_RS09115	COG2067	long-chain fatty acid transport protein
MTO69_RS09130	COG3088	subunit of a heme lyase
MTO69_RS09130	COG4235	cytochrome complex assembly
MTO69_RS09135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MTO69_RS09140	COG1138	Cytochrome C-type biogenesis protein
MTO69_RS09155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MTO69_RS09160	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MTO69_RS09165	COG4133	protoheme IX ABC transporter activity
MTO69_RS09175	COG0835	chemotaxis
MTO69_RS09185	COG1192	Involved in chromosome partitioning
MTO69_RS09190	COG2201	protein-glutamate methylesterase activity
MTO69_RS09195	COG2198	Histidine kinase
MTO69_RS09195	COG0784	Response regulator, receiver
MTO69_RS09195	COG0643	Histidine kinase
MTO69_RS09200	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MTO69_RS09225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MTO69_RS09230	COG2062	phosphohistidine phosphatase, SixA
MTO69_RS09240	COG3102	Protein conserved in bacteria
MTO69_RS09245	COG0018	arginyl-trna synthetase
MTO69_RS09260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MTO69_RS09265	COG1918	ferrous iron import across plasma membrane
MTO69_RS09270	COG4977	sequence-specific DNA binding
MTO69_RS09275	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
MTO69_RS09280	COG1121	(ABC) transporter
MTO69_RS09285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MTO69_RS09290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MTO69_RS09295	COG1286	toxin biosynthetic process
MTO69_RS09300	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
MTO69_RS09305	COG0285	dihydrofolate synthase activity
MTO69_RS09310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MTO69_RS09315	COG0101	tRNA pseudouridine synthase activity
MTO69_RS09325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MTO69_RS09335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MTO69_RS09360	COG3101	peptidyl-lysine hydroxylation
MTO69_RS09365	COG2860	membrane
MTO69_RS09370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MTO69_RS09375	COG2890	protein-(glutamine-N5) methyltransferase activity
MTO69_RS09380	COG2840	Smr protein MutS2
MTO69_RS09390	COG1684	flagellar biosynthetic protein fliR
MTO69_RS09395	COG1987	bacterial-type flagellum assembly
MTO69_RS09420	COG1580	Controls the rotational direction of flagella during chemotaxis
MTO69_RS09445	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MTO69_RS09455	COG1677	Flagellar hook-basal body complex protein FliE
MTO69_RS09475	COG1516	flagellar protein fliS
MTO69_RS09485	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MTO69_RS09495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MTO69_RS09510	COG2837	iron assimilation
MTO69_RS09520	COG3088	subunit of a heme lyase
MTO69_RS09520	COG4235	cytochrome complex assembly
MTO69_RS09530	COG1138	Cytochrome C-type biogenesis protein
MTO69_RS09535	COG3301	Polysulphide reductase, NrfD
MTO69_RS09540	COG0437	4 iron, 4 sulfur cluster binding
MTO69_RS09545	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
MTO69_RS09550	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
MTO69_RS09570	COG1393	Belongs to the ArsC family
MTO69_RS09575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MTO69_RS09580	COG1876	peptidase activity
MTO69_RS09590	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
MTO69_RS09600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MTO69_RS09600	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MTO69_RS09615	COG1611	Belongs to the LOG family
MTO69_RS09620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MTO69_RS09625	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
MTO69_RS09630	COG2363	Small membrane protein
MTO69_RS09640	COG0583	DNA-binding transcription factor activity
MTO69_RS09645	COG0301	tRNA thio-modification
MTO69_RS09645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MTO69_RS09655	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MTO69_RS09665	COG0142	geranyltranstransferase activity
MTO69_RS09675	COG0564	pseudouridine synthase activity
MTO69_RS09680	COG3098	single-species biofilm formation
MTO69_RS09715	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTO69_RS09720	COG0567	Dehydrogenase, E1 component
MTO69_RS09730	COG1053	succinate dehydrogenase
MTO69_RS09735	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MTO69_RS09750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MTO69_RS09760	COG0033	Phosphoglucomutase
MTO69_RS09765	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
MTO69_RS09770	COG0596	Alpha beta hydrolase
MTO69_RS09780	COG0716	FMN binding
MTO69_RS09790	COG0735	belongs to the Fur family
MTO69_RS09795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MTO69_RS09800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTO69_RS09800	COG2190	(PTS) system
MTO69_RS09800	COG1263	PTS System
MTO69_RS09805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MTO69_RS09810	COG1846	Transcriptional regulator
MTO69_RS09810	COG1940	carbohydrate kinase activity
MTO69_RS09815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MTO69_RS09815	COG4651	solute:proton antiporter activity
MTO69_RS09820	COG0367	asparagine synthase
MTO69_RS09825	COG3104	oligopeptide transport
MTO69_RS09850	COG2840	Smr protein MutS2
MTO69_RS09855	COG1187	pseudouridine synthase activity
MTO69_RS09860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MTO69_RS09865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MTO69_RS09870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MTO69_RS09895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MTO69_RS09895	COG0047	phosphoribosylformylglycinamidine synthase activity
MTO69_RS09900	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MTO69_RS09915	COG0583	DNA-binding transcription factor activity
MTO69_RS09920	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MTO69_RS09925	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MTO69_RS09930	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MTO69_RS09965	COG0484	heat shock protein binding
MTO69_RS09970	COG0443	Heat shock 70 kDa protein
MTO69_RS09975	COG1301	dicarboxylic acid transport
MTO69_RS09985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MTO69_RS09990	COG0497	DNA recombination
MTO69_RS09995	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MTO69_RS10005	COG2914	Belongs to the UPF0125 (RnfH) family
MTO69_RS10010	COG2867	negative regulation of translational initiation
MTO69_RS10025	COG0582	viral genome integration into host DNA
MTO69_RS10060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MTO69_RS10070	COG0732	type I restriction modification DNA specificity domain
MTO69_RS10075	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MTO69_RS10100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MTO69_RS10105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MTO69_RS10115	COG0579	oxidoreductase
MTO69_RS10120	COG0009	L-threonylcarbamoyladenylate synthase
MTO69_RS10140	COG0204	Acyl-transferase
MTO69_RS10145	COG3153	acetyltransferase
MTO69_RS10145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MTO69_RS10150	COG2873	o-acetylhomoserine
MTO69_RS10170	COG0583	DNA-binding transcription factor activity
MTO69_RS10180	COG1115	amino acid carrier protein
MTO69_RS10185	COG1584	GPR1 FUN34 yaaH family protein
MTO69_RS10195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MTO69_RS10195	COG0519	Catalyzes the synthesis of GMP from XMP
MTO69_RS10200	COG0516	GMP reductase activity
MTO69_RS10200	COG0517	IMP dehydrogenase activity
MTO69_RS10215	COG2199	diguanylate cyclase activity
MTO69_RS10215	COG2203	Gaf domain
MTO69_RS10220	COG4565	transcriptional regulatory protein
MTO69_RS10225	COG3290	protein histidine kinase activity
MTO69_RS10230	COG0471	metal ion transport
MTO69_RS10240	COG1160	GTP binding
MTO69_RS10245	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MTO69_RS10250	COG2976	Protein conserved in bacteria
MTO69_RS10255	COG0124	histidyl-tRNA synthetase
MTO69_RS10260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MTO69_RS10265	COG1426	Protein conserved in bacteria
MTO69_RS10270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MTO69_RS10275	COG2166	iron-sulfur cluster assembly
MTO69_RS10280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MTO69_RS10285	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MTO69_RS10305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MTO69_RS10310	COG1074	ATP-dependent DNA helicase activity
MTO69_RS10315	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MTO69_RS10330	COG0395	ABC-type sugar transport system, permease component
MTO69_RS10340	COG3842	ATPase activity
MTO69_RS10345	COG3842	ATPase activity
MTO69_RS10350	COG3284	Transcriptional regulator
MTO69_RS10365	COG3141	response to X-ray
MTO69_RS10370	COG3142	Participates in the control of copper homeostasis
MTO69_RS10390	COG0704	Plays a role in the regulation of phosphate uptake
MTO69_RS10395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MTO69_RS10400	COG0581	inorganic phosphate transmembrane transporter activity
MTO69_RS10410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MTO69_RS10415	COG0248	Ppx GppA phosphatase
MTO69_RS10425	COG5002	protein histidine kinase activity
MTO69_RS10430	COG0745	RESPONSE REGULATOR receiver
MTO69_RS10440	COG0826	peptidase U32
MTO69_RS10445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MTO69_RS10450	COG1294	oxidase, subunit
MTO69_RS10455	COG1271	oxidase subunit
MTO69_RS10475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MTO69_RS10480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MTO69_RS10485	COG1862	Preprotein translocase
MTO69_RS10495	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MTO69_RS10500	COG0517	IMP dehydrogenase activity
MTO69_RS10505	COG3706	GGDEF domain
MTO69_RS10520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MTO69_RS10525	COG0583	DNA-binding transcription factor activity
MTO69_RS10530	COG0450	alkyl hydroperoxide reductase
MTO69_RS10535	COG2171	N-acyltransferase activity
MTO69_RS10545	COG1349	DNA-binding transcription factor activity
MTO69_RS10550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MTO69_RS10565	COG1609	Transcriptional regulator
MTO69_RS10570	COG4989	oxidoreductase activity
MTO69_RS10580	COG2211	Major facilitator Superfamily
MTO69_RS10590	COG1609	Transcriptional regulator
MTO69_RS10595	COG2017	converts alpha-aldose to the beta-anomer
MTO69_RS10605	COG1085	galactose-1-phosphate uridylyltransferase
MTO69_RS10610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MTO69_RS10615	COG1309	transcriptional regulator
MTO69_RS10625	COG0534	Mate efflux family protein
MTO69_RS10635	COG3250	beta-galactosidase activity
MTO69_RS10645	COG0395	ABC-type sugar transport system, permease component
MTO69_RS10650	COG1175	transmembrane transport
MTO69_RS10655	COG3842	ATPase activity
MTO69_RS10665	COG2059	Chromate
MTO69_RS10715	COG4964	Belongs to the GSP D family
MTO69_RS10745	COG2169	Transcriptional regulator
MTO69_RS10750	COG1022	Amp-dependent synthetase and ligase
MTO69_RS10755	COG0583	DNA-binding transcription factor activity
MTO69_RS10760	COG0583	DNA-binding transcription factor activity
MTO69_RS10765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MTO69_RS10770	COG2199	diguanylate cyclase activity
MTO69_RS10785	COG2975	iron-sulfur cluster assembly
MTO69_RS10790	COG0633	Ferredoxin
MTO69_RS10795	COG0443	Heat shock 70 kDa protein
MTO69_RS10810	COG0822	iron-sulfur transferase activity
MTO69_RS10830	COG0483	inositol monophosphate 1-phosphatase activity
MTO69_RS10870	COG0542	response to heat
MTO69_RS10880	COG0564	pseudouridine synthase activity
MTO69_RS10885	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MTO69_RS10890	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MTO69_RS10895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MTO69_RS10900	COG0077	Prephenate dehydratase
MTO69_RS10900	COG1605	Chorismate mutase
MTO69_RS10905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MTO69_RS10910	COG5001	Diguanylate cyclase
MTO69_RS10915	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
MTO69_RS10920	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
MTO69_RS10925	COG0741	lytic transglycosylase activity
MTO69_RS10930	COG0488	(ABC) transporter
MTO69_RS10940	COG0739	heme binding
MTO69_RS10945	COG0287	Prephenate dehydrogenase
MTO69_RS10945	COG1605	Chorismate mutase
MTO69_RS10950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MTO69_RS10955	COG3275	phosphorelay sensor kinase activity
MTO69_RS10960	COG3279	Response regulator of the LytR AlgR family
MTO69_RS10970	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MTO69_RS10975	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MTO69_RS10985	COG1966	Carbon starvation protein
MTO69_RS10990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MTO69_RS10995	COG1047	Peptidyl-prolyl cis-trans
MTO69_RS11005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MTO69_RS11010	COG0196	riboflavin kinase activity
MTO69_RS11015	COG0728	peptidoglycan biosynthetic process
MTO69_RS11020	COG0268	Binds directly to 16S ribosomal RNA
MTO69_RS11025	COG0640	Transcriptional regulator
MTO69_RS11030	COG0583	DNA-binding transcription factor activity
MTO69_RS11035	COG1283	sodium-dependent phosphate transmembrane transporter activity
MTO69_RS11045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MTO69_RS11050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MTO69_RS11055	COG0730	response to heat
MTO69_RS11065	COG0494	nUDIX hydrolase
MTO69_RS11070	COG3066	DNA modification
MTO69_RS11080	COG0667	Aldo Keto reductase
MTO69_RS11090	COG3829	transcription factor binding
MTO69_RS11090	COG3290	protein histidine kinase activity
MTO69_RS11095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MTO69_RS11115	COG0513	Belongs to the DEAD box helicase family
MTO69_RS11140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTO69_RS11145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MTO69_RS11150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MTO69_RS11160	COG1534	Rna-binding protein
MTO69_RS11165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MTO69_RS11170	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MTO69_RS11175	COG2027	D-alanyl-D-alanine carboxypeptidase
MTO69_RS11185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MTO69_RS11190	COG0739	heme binding
MTO69_RS11205	COG0316	Belongs to the HesB IscA family
MTO69_RS11210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MTO69_RS11215	COG0628	permease
MTO69_RS11230	COG0747	negative chemotaxis
MTO69_RS11240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO69_RS11245	COG0444	Belongs to the ABC transporter superfamily
MTO69_RS11250	COG4608	Belongs to the ABC transporter superfamily
MTO69_RS11260	COG2971	BadF BadG BcrA BcrD
MTO69_RS11275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTO69_RS11280	COG3842	ATPase activity
MTO69_RS11290	COG1840	ABC-type Fe3 transport system, periplasmic component
MTO69_RS11295	COG0004	ammonium transporteR
MTO69_RS11310	COG1049	propionate catabolic process, 2-methylcitrate cycle
MTO69_RS11315	COG1752	Esterase of the alpha-beta hydrolase superfamily
MTO69_RS11320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MTO69_RS11325	COG1643	Atp-dependent helicase
MTO69_RS11335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MTO69_RS11350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MTO69_RS11355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MTO69_RS11365	COG0842	Transport permease protein
MTO69_RS11370	COG1131	(ABC) transporter
MTO69_RS11375	COG0659	secondary active sulfate transmembrane transporter activity
MTO69_RS11380	COG0288	reversible hydration of carbon dioxide
MTO69_RS11395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MTO69_RS11400	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTO69_RS11405	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MTO69_RS11410	COG2186	Transcriptional regulator
MTO69_RS11420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MTO69_RS11425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MTO69_RS11430	COG4974	Belongs to the 'phage' integrase family
MTO69_RS11435	COG0716	FMN binding
MTO69_RS11445	COG0157	Belongs to the NadC ModD family
MTO69_RS11455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MTO69_RS11460	COG1459	type II secretion system
MTO69_RS11470	COG0237	dephospho-CoA kinase activity
MTO69_RS11475	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MTO69_RS11480	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MTO69_RS11490	COG0336	Belongs to the RNA methyltransferase TrmD family
MTO69_RS11500	COG0228	four-way junction DNA binding
MTO69_RS11505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MTO69_RS11510	COG4137	Cytochrome C assembly protein
MTO69_RS11515	COG4536	flavin adenine dinucleotide binding
MTO69_RS11520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MTO69_RS11540	COG0585	pseudouridine synthase activity
MTO69_RS11555	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MTO69_RS11560	COG1968	undecaprenyl-diphosphatase activity
MTO69_RS11565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MTO69_RS11570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MTO69_RS11575	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MTO69_RS11580	COG2267	carboxylic ester hydrolase activity
MTO69_RS11585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MTO69_RS11590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MTO69_RS11595	COG1610	YqeY-like protein
MTO69_RS11600	COG0358	DNA primase activity
MTO69_RS11620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MTO69_RS11625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MTO69_RS11630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MTO69_RS11635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MTO69_RS11640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MTO69_RS11655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MTO69_RS11660	COG3610	response to peptide
MTO69_RS11665	COG2966	Psort location CytoplasmicMembrane, score
MTO69_RS11670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MTO69_RS11680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MTO69_RS11685	COG0142	geranyltranstransferase activity
MTO69_RS11695	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MTO69_RS11700	COG2213	PTS system mannitol-specific
MTO69_RS11700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTO69_RS11710	COG3722	fumarate hydratase activity
MTO69_RS11720	COG1349	DNA-binding transcription factor activity
MTO69_RS11725	COG0469	pyruvate kinase activity
MTO69_RS11735	COG0583	DNA-binding transcription factor activity
MTO69_RS11750	COG0668	transmembrane transport
MTO69_RS11755	COG0191	fructose-bisphosphate aldolase activity
MTO69_RS11765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MTO69_RS11775	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MTO69_RS11780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MTO69_RS11795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MTO69_RS11800	COG0189	ligase activity
MTO69_RS11805	COG1678	Uncharacterized ACR, COG1678
MTO69_RS11810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MTO69_RS11825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MTO69_RS11830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MTO69_RS11835	COG0762	integral membrane protein
MTO69_RS11850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MTO69_RS11855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MTO69_RS11865	COG2066	Belongs to the glutaminase family
MTO69_RS11880	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MTO69_RS11885	COG0741	lytic transglycosylase activity
MTO69_RS11940	COG0204	Acyl-transferase
MTO69_RS11945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MTO69_RS11950	COG5007	Belongs to the BolA IbaG family
MTO69_RS11955	COG3113	response to antibiotic
MTO69_RS11960	COG2854	intermembrane phospholipid transfer
MTO69_RS11965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MTO69_RS11970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MTO69_RS11975	COG1127	ABC transporter
MTO69_RS11990	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MTO69_RS12000	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MTO69_RS12005	COG1137	ATPase activity
MTO69_RS12015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MTO69_RS12020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTO69_RS12025	COG1660	Displays ATPase and GTPase activities
MTO69_RS12030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTO69_RS12035	COG2239	Acts as a magnesium transporter
MTO69_RS12040	COG0646	methionine synthase
MTO69_RS12040	COG1410	methionine synthase
MTO69_RS12050	COG3706	GGDEF domain
MTO69_RS12110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MTO69_RS12115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MTO69_RS12135	COG0735	belongs to the Fur family
MTO69_RS12145	COG0529	Catalyzes the synthesis of activated sulfate
MTO69_RS12150	COG0471	metal ion transport
MTO69_RS12150	COG3273	potassium ion transport
MTO69_RS12165	COG1648	precorrin-2 dehydrogenase activity
MTO69_RS12165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MTO69_RS12170	COG0737	Belongs to the 5'-nucleotidase family
MTO69_RS12180	COG2153	protein acetylation
MTO69_RS12185	COG0697	spore germination
MTO69_RS12195	COG0545	Peptidyl-prolyl cis-trans isomerase
MTO69_RS12205	COG0203	ribosomal protein L17
MTO69_RS12210	COG0202	RNA polymerase activity
MTO69_RS12220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MTO69_RS12225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MTO69_RS12230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MTO69_RS12235	COG0201	protein transport
MTO69_RS12240	COG0200	Binds to the 23S rRNA
MTO69_RS12245	COG1841	ribosomal large subunit assembly
MTO69_RS12260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MTO69_RS12275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MTO69_RS12290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MTO69_RS12305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MTO69_RS12310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MTO69_RS12315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MTO69_RS12330	COG0088	Forms part of the polypeptide exit tunnel
MTO69_RS12335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MTO69_RS12345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MTO69_RS12350	COG0557	exoribonuclease II activity
MTO69_RS12355	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
MTO69_RS12360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MTO69_RS12365	COG1446	asparaginase
MTO69_RS12370	COG1047	Peptidyl-prolyl cis-trans
MTO69_RS12375	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
MTO69_RS12385	COG2249	NAD(P)H dehydrogenase (quinone) activity
MTO69_RS12390	COG0488	(ABC) transporter
MTO69_RS12400	COG0429	hydrolase of the alpha beta-hydrolase fold
MTO69_RS12410	COG3954	Phosphoribulokinase
MTO69_RS12415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MTO69_RS12425	COG1012	belongs to the aldehyde dehydrogenase family
MTO69_RS12435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MTO69_RS12450	COG3030	protein affecting phage T7 exclusion by the F plasmid
MTO69_RS12455	COG1027	Aspartate ammonia-lyase
MTO69_RS12460	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MTO69_RS12465	COG1288	antiporter activity
MTO69_RS12480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MTO69_RS12485	COG0540	Belongs to the ATCase OTCase family
MTO69_RS12490	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MTO69_RS12495	COG1438	arginine binding
MTO69_RS12500	COG4232	protein-disulfide reductase activity
MTO69_RS12510	COG2095	MarC family integral membrane protein
MTO69_RS12520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MTO69_RS12535	COG1045	serine acetyltransferase
MTO69_RS12550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MTO69_RS12555	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MTO69_RS12560	COG1053	succinate dehydrogenase
MTO69_RS12565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MTO69_RS12570	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MTO69_RS12585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MTO69_RS12590	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MTO69_RS12595	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MTO69_RS12600	COG1609	Transcriptional regulator
MTO69_RS12605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MTO69_RS12615	COG0281	malic enzyme
MTO69_RS12620	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
MTO69_RS12625	COG0626	cystathionine gamma-synthase activity
MTO69_RS12630	COG0460	homoserine dehydrogenase
MTO69_RS12630	COG0527	aspartate kinase activity
MTO69_RS12635	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MTO69_RS12640	COG3074	FtsZ-dependent cytokinesis
MTO69_RS12645	COG1494	fructose-1,6-bisphosphatase
MTO69_RS12650	COG5001	Diguanylate cyclase
MTO69_RS12650	COG2203	Gaf domain
MTO69_RS12650	COG4251	negative regulation of phosphorylation
MTO69_RS12650	COG3706	GGDEF domain
MTO69_RS12710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MTO69_RS12720	COG4206	TonB-dependent receptor
MTO69_RS12725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MTO69_RS12740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MTO69_RS12745	COG0534	Mate efflux family protein
MTO69_RS12755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MTO69_RS12760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MTO69_RS12765	COG2937	Belongs to the GPAT DAPAT family
MTO69_RS12770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MTO69_RS12775	COG3161	chorismate lyase activity
MTO69_RS12780	COG1580	Controls the rotational direction of flagella during chemotaxis
MTO69_RS12785	COG0705	Rhomboid family
MTO69_RS12790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MTO69_RS12800	COG2177	Part of the ABC transporter FtsEX involved in
MTO69_RS12805	COG2884	Cell division ATP-binding protein ftsE
MTO69_RS12810	COG0552	protein localization to endoplasmic reticulum
MTO69_RS12810	COG0552	protein localization to endoplasmic reticulum
MTO69_RS12815	COG0742	ribosomal rna small subunit methyltransferase
MTO69_RS12825	COG2095	MarC family integral membrane protein
MTO69_RS12865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MTO69_RS12870	COG0640	Transcriptional regulator
MTO69_RS12875	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MTO69_RS12880	COG1280	lysine exporter protein (LysE YggA)
MTO69_RS12885	COG2267	carboxylic ester hydrolase activity
MTO69_RS12890	COG0561	phosphatase activity
MTO69_RS12910	COG3287	FIST C domain
MTO69_RS12910	COG2200	EAL domain
MTO69_RS12910	COG2199	diguanylate cyclase activity
MTO69_RS12915	COG1011	Hydrolase
MTO69_RS12920	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MTO69_RS12930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MTO69_RS12935	COG0019	diaminopimelate decarboxylase activity
MTO69_RS12950	COG3072	Adenylate cyclase
MTO69_RS12960	COG1587	Uroporphyrinogen-III synthase
MTO69_RS12965	COG2959	enzyme of heme biosynthesis
MTO69_RS12970	COG3071	HemY protein
MTO69_RS13045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MTO69_RS13060	COG3118	belongs to the thioredoxin family
MTO69_RS13070	COG0248	Ppx GppA phosphatase
MTO69_RS13075	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MTO69_RS13085	COG0514	ATP-dependent DNA helicase (RecQ)
MTO69_RS13090	COG2962	Rard protein
MTO69_RS13100	COG1280	lysine exporter protein (LysE YggA)
MTO69_RS13105	COG0210	DNA helicase
MTO69_RS13115	COG3220	belongs to the UPF0276 family
MTO69_RS13135	COG0339	signal peptide processing
MTO69_RS13140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MTO69_RS13145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MTO69_RS13155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO69_RS13160	COG0601	transmembrane transport
MTO69_RS13165	COG0747	negative chemotaxis
MTO69_RS13170	COG4172	Belongs to the ABC transporter superfamily
MTO69_RS13210	COG1309	transcriptional regulator
MTO69_RS13215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MTO69_RS13220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MTO69_RS13225	COG2960	long-chain fatty acid transporting porin activity
MTO69_RS13230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MTO69_RS13235	COG0583	DNA-binding transcription factor activity
MTO69_RS13270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MTO69_RS13270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MTO69_RS13285	COG0084	hydrolase, TatD family'
MTO69_RS13290	COG0805	protein transport
MTO69_RS13295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MTO69_RS13300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MTO69_RS13305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MTO69_RS13310	COG3165	ubiquinone biosynthetic process from chorismate
MTO69_RS13315	COG2226	methyltransferase
MTO69_RS13320	COG1322	Protein conserved in bacteria
MTO69_RS13330	COG1639	'signal transduction protein
MTO69_RS13335	COG2081	HI0933 family
MTO69_RS13345	COG1528	Iron-storage protein
MTO69_RS13350	COG0589	response to stress
MTO69_RS13370	COG5001	Diguanylate cyclase
MTO69_RS13370	COG5002	protein histidine kinase activity
MTO69_RS13375	COG1522	sequence-specific DNA binding
MTO69_RS13385	COG2814	Major facilitator Superfamily
MTO69_RS13395	COG0006	proline dipeptidase activity
MTO69_RS13395	COG0006	proline dipeptidase activity
MTO69_RS13410	COG2104	thiamine diphosphate biosynthetic process
MTO69_RS13415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MTO69_RS13485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MTO69_RS13490	COG1739	Uncharacterized protein family UPF0029
MTO69_RS13500	COG0183	Belongs to the thiolase family
MTO69_RS13510	COG0765	amino acid transport
MTO69_RS13520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MTO69_RS13525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MTO69_RS13530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MTO69_RS13540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MTO69_RS13545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MTO69_RS13555	COG0356	it plays a direct role in the translocation of protons across the membrane
MTO69_RS13560	COG3312	ion transport
MTO69_RS13565	COG1475	DNA binding
MTO69_RS13570	COG1192	Involved in chromosome partitioning
MTO69_RS13575	COG0357	Ribosomal RNA small subunit methyltransferase G
MTO69_RS13580	COG0445	tRNA wobble uridine modification
MTO69_RS13585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MTO69_RS13590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MTO69_RS13595	COG0706	membrane insertase activity
MTO69_RS13605	COG0594	ribonuclease P activity
MTO69_RS13615	COG1126	abc transporter atp-binding protein
MTO69_RS13635	COG3240	lipase activity
MTO69_RS13670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MTO69_RS13675	COG1288	antiporter activity
MTO69_RS13685	COG1902	pentaerythritol trinitrate reductase activity
MTO69_RS13695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTO69_RS13695	COG1263	PTS System
MTO69_RS13700	COG1486	melibiose metabolic process
MTO69_RS13705	COG2188	Transcriptional regulator
MTO69_RS13725	COG0640	Transcriptional regulator
MTO69_RS13755	COG1328	CTP reductase activity
MTO69_RS13760	COG0602	queuosine metabolic process
MTO69_RS13770	COG0189	ligase activity
MTO69_RS13770	COG4067	protein conserved in archaea
MTO69_RS13780	COG0545	Peptidyl-prolyl cis-trans isomerase
MTO69_RS13805	COG2926	Belongs to the UPF0265 family
MTO69_RS13820	COG2827	Endonuclease containing a URI domain
MTO69_RS13855	COG1289	transmembrane transporter activity
MTO69_RS13860	COG0210	DNA helicase
MTO69_RS13875	COG0484	heat shock protein binding
MTO69_RS13880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTO69_RS13890	COG5001	Diguanylate cyclase
MTO69_RS13890	COG3300	MHYT domain
MTO69_RS13895	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MTO69_RS13905	COG4181	ATPase activity
MTO69_RS13910	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MTO69_RS13920	COG1984	allophanate hydrolase subunit 2
MTO69_RS13930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MTO69_RS13935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MTO69_RS13945	COG3005	denitrification pathway
MTO69_RS13955	COG0243	molybdopterin cofactor binding
MTO69_RS13965	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
MTO69_RS13965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MTO69_RS13970	COG3850	Histidine kinase
MTO69_RS13975	COG2197	response regulator
MTO69_RS14000	COG3038	cytochrome b561
MTO69_RS14010	COG2116	formate transmembrane transporter activity
MTO69_RS14015	COG0583	DNA-binding transcription factor activity
MTO69_RS14025	COG3593	DNA synthesis involved in DNA repair
MTO69_RS14030	COG0737	Belongs to the 5'-nucleotidase family
MTO69_RS14065	COG4783	chaperone-mediated protein folding
MTO69_RS14070	COG2050	protein possibly involved in aromatic compounds catabolism
MTO69_RS14080	COG4533	DNA binding
MTO69_RS14095	COG0583	DNA-binding transcription factor activity
MTO69_RS14100	COG0045	succinate-CoA ligase (ADP-forming) activity
MTO69_RS14100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTO69_RS14100	COG1042	CoA-binding domain protein
MTO69_RS14105	COG3266	domain, Protein
MTO69_RS14110	COG1181	Belongs to the D-alanine--D-alanine ligase family
MTO69_RS14125	COG0023	Translation Initiation Factor
MTO69_RS14140	COG3140	Belongs to the UPF0181 family
MTO69_RS14155	COG0745	RESPONSE REGULATOR receiver
MTO69_RS14165	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MTO69_RS14170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MTO69_RS14185	COG3706	GGDEF domain
MTO69_RS14195	COG2203	Gaf domain
MTO69_RS14195	COG3706	GGDEF domain
MTO69_RS14195	COG4251	negative regulation of phosphorylation
MTO69_RS14195	COG5001	Diguanylate cyclase
MTO69_RS14205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MTO69_RS14210	COG4149	molybdate abc transporter
MTO69_RS14215	COG0725	ABC transporter, periplasmic molybdate-binding protein
MTO69_RS14220	COG1492	cobalamin metabolic process
MTO69_RS14235	COG1609	Transcriptional regulator
MTO69_RS14240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTO69_RS14240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTO69_RS14245	COG1105	Belongs to the carbohydrate kinase PfkB family
MTO69_RS14250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MTO69_RS14250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MTO69_RS14250	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MTO69_RS14260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MTO69_RS14265	COG2207	Transcriptional regulator
MTO69_RS14270	COG1979	alcohol dehydrogenase
MTO69_RS14280	COG2205	protein histidine kinase activity
MTO69_RS14280	COG2198	Histidine kinase
MTO69_RS14280	COG0784	Response regulator, receiver
MTO69_RS14285	COG1879	ABC-type sugar transport system periplasmic component
MTO69_RS14290	COG1803	Methylglyoxal synthase
MTO69_RS14295	COG0546	phosphoglycolate phosphatase activity
MTO69_RS14310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTO69_RS14315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MTO69_RS14325	COG0456	acetyltransferase
MTO69_RS14325	COG1214	PFAM Peptidase M22, glycoprotease
MTO69_RS14340	COG0513	Belongs to the DEAD box helicase family
MTO69_RS14350	COG0814	amino acid
MTO69_RS14355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MTO69_RS14355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MTO69_RS14360	COG0513	Belongs to the DEAD box helicase family
MTO69_RS14365	COG0302	gtp cyclohydrolase
MTO69_RS14375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MTO69_RS14385	COG2897	thiosulfate sulfurtransferase activity
MTO69_RS14390	COG2814	Major facilitator Superfamily
MTO69_RS14395	COG1794	racemase activity, acting on amino acids and derivatives
MTO69_RS14410	COG0183	Belongs to the thiolase family
MTO69_RS14435	COG1309	transcriptional regulator
MTO69_RS14445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MTO69_RS14450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MTO69_RS14455	COG2203	Gaf domain
MTO69_RS14455	COG5001	Diguanylate cyclase
MTO69_RS14455	COG4251	negative regulation of phosphorylation
MTO69_RS14455	COG3706	GGDEF domain
MTO69_RS14465	COG0523	cobalamin synthesis protein
MTO69_RS14470	COG0038	chloride channel
MTO69_RS14480	COG0156	8-amino-7-oxononanoate synthase activity
MTO69_RS14485	COG0784	Response regulator, receiver
MTO69_RS14485	COG2205	protein histidine kinase activity
MTO69_RS14490	COG0419	ATPase involved in DNA repair
MTO69_RS14495	COG0420	3'-5' exonuclease activity
MTO69_RS14500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MTO69_RS14505	COG3118	belongs to the thioredoxin family
MTO69_RS14535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MTO69_RS14535	COG2146	nitrite reductase [NAD(P)H] activity
MTO69_RS14540	COG1116	anion transmembrane transporter activity
MTO69_RS14545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MTO69_RS14550	COG1116	anion transmembrane transporter activity
MTO69_RS14550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MTO69_RS14565	COG1648	precorrin-2 dehydrogenase activity
MTO69_RS14565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MTO69_RS14570	COG0243	molybdopterin cofactor binding
MTO69_RS14590	COG2315	Protein conserved in bacteria
MTO69_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
MTO69_RS14610	COG1024	Enoyl-CoA hydratase
MTO69_RS14615	COG1024	Enoyl-CoA hydratase
MTO69_RS14620	COG1960	acyl-CoA dehydrogenase activity
MTO69_RS14630	COG0183	Belongs to the thiolase family
MTO69_RS14640	COG1960	acyl-CoA dehydrogenase activity
MTO69_RS14645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTO69_RS14650	COG1024	Enoyl-CoA hydratase
MTO69_RS14650	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTO69_RS14665	COG3706	GGDEF domain
MTO69_RS14675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MTO69_RS14685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MTO69_RS14690	COG1132	(ABC) transporter
MTO69_RS14700	COG1609	Transcriptional regulator
MTO69_RS14705	COG0800	Aldolase
MTO69_RS14710	COG0129	dihydroxy-acid dehydratase activity
MTO69_RS14715	COG3265	gluconokinase activity
MTO69_RS14720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MTO69_RS14730	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MTO69_RS14735	COG0183	Belongs to the thiolase family
MTO69_RS14740	COG1028	Short-chain dehydrogenase reductase Sdr
MTO69_RS14765	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MTO69_RS14785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTO69_RS14785	COG1263	PTS System
MTO69_RS14800	COG0191	fructose-bisphosphate aldolase activity
MTO69_RS14805	COG2084	Dehydrogenase
MTO69_RS14810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTO69_RS14815	COG1349	DNA-binding transcription factor activity
MTO69_RS14825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MTO69_RS14830	COG1882	Formate acetyltransferase
MTO69_RS14855	COG1501	Belongs to the glycosyl hydrolase 31 family
MTO69_RS14860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MTO69_RS14865	COG0583	DNA-binding transcription factor activity
MTO69_RS14870	COG1349	DNA-binding transcription factor activity
MTO69_RS14875	COG1882	Formate acetyltransferase
MTO69_RS14880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MTO69_RS14885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MTO69_RS14905	COG0840	transmembrane signaling receptor activity
MTO69_RS14910	COG1115	amino acid carrier protein
MTO69_RS14945	COG0840	transmembrane signaling receptor activity
MTO69_RS14975	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MTO69_RS14985	COG2176	DNA-directed DNA polymerase activity
MTO69_RS14985	COG5002	protein histidine kinase activity
MTO69_RS14990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MTO69_RS14995	COG1846	Transcriptional regulator
MTO69_RS15015	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MTO69_RS15025	COG0494	nUDIX hydrolase
MTO69_RS15030	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
MTO69_RS15040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MTO69_RS15045	COG0784	Response regulator, receiver
MTO69_RS15045	COG0835	chemotaxis
MTO69_RS15050	COG3706	GGDEF domain
MTO69_RS15065	COG1760	l-serine dehydratase
MTO69_RS15070	COG2866	Carboxypeptidase
MTO69_RS15075	COG2188	Transcriptional regulator
MTO69_RS15090	COG1011	Hydrolase
MTO69_RS15100	COG1454	alcohol dehydrogenase
MTO69_RS15110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MTO69_RS15115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MTO69_RS15140	COG2154	pterin-4-alpha-carbinolamine dehydratase
MTO69_RS15145	COG3186	Phenylalanine-4-hydroxylase
MTO69_RS15150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTO69_RS15165	COG1054	Belongs to the UPF0176 family
MTO69_RS15170	COG0443	Heat shock 70 kDa protein
MTO69_RS15205	COG0583	DNA-binding transcription factor activity
MTO69_RS15230	COG3275	phosphorelay sensor kinase activity
MTO69_RS15250	COG1136	(ABC) transporter
MTO69_RS15270	COG4176	ABC-type proline glycine betaine transport system permease component
MTO69_RS15275	COG2113	Glycine betaine
MTO69_RS15285	COG1253	flavin adenine dinucleotide binding
MTO69_RS15290	COG0583	DNA-binding transcription factor activity
MTO69_RS15295	COG2814	Major facilitator Superfamily
MTO69_RS15300	COG3795	YCII-related domain
MTO69_RS15310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MTO69_RS15330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MTO69_RS15340	COG1733	regulation of RNA biosynthetic process
MTO69_RS15345	COG0569	domain protein
MTO69_RS15345	COG0189	ligase activity
MTO69_RS15355	COG4628	conserved protein (DUF2132)
MTO69_RS15360	COG0513	Belongs to the DEAD box helicase family
MTO69_RS15370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MTO69_RS15390	COG3530	Putative quorum-sensing-regulated virulence factor
MTO69_RS15405	COG1686	Belongs to the peptidase S11 family
MTO69_RS15420	COG3036	rescue of stalled ribosome
MTO69_RS15425	COG1278	Cold shock
MTO69_RS15440	COG1017	nitric oxide dioxygenase activity
MTO69_RS15440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MTO69_RS15445	COG3604	Transcriptional regulator
MTO69_RS15460	COG2249	NAD(P)H dehydrogenase (quinone) activity
MTO69_RS15480	COG0697	spore germination
MTO69_RS15495	COG2814	Major facilitator Superfamily
MTO69_RS15500	COG0583	DNA-binding transcription factor activity
MTO69_RS15505	COG5001	Diguanylate cyclase
MTO69_RS15510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MTO69_RS15535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTO69_RS15545	COG2096	Adenosyltransferase
MTO69_RS15550	COG0748	coenzyme F420 binding
MTO69_RS15555	COG3721	Heme iron utilization protein
MTO69_RS15565	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MTO69_RS15570	COG0811	peptide transport
MTO69_RS15575	COG0848	biopolymer transport protein
MTO69_RS15585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTO69_RS15590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MTO69_RS15600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MTO69_RS15610	COG0739	heme binding
MTO69_RS15630	COG3314	Sporulation integral membrane protein YlbJ
MTO69_RS15640	COG2203	Gaf domain
MTO69_RS15640	COG2199	diguanylate cyclase activity
MTO69_RS15675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MTO69_RS15680	COG0581	inorganic phosphate transmembrane transporter activity
MTO69_RS15685	COG0573	inorganic phosphate transmembrane transporter activity
MTO69_RS15700	COG0513	Belongs to the DEAD box helicase family
MTO69_RS15710	COG1376	ErfK ybiS ycfS ynhG family protein
MTO69_RS15710	COG1388	LysM domain
MTO69_RS15715	COG0415	Belongs to the DNA photolyase family
MTO69_RS15720	COG0789	Transcriptional regulator
MTO69_RS15725	COG3272	Protein of unknown function (DUF1722)
MTO69_RS15730	COG0813	purine-nucleoside phosphorylase activity
MTO69_RS15760	COG1566	PFAM secretion protein HlyD family protein
MTO69_RS15775	COG0840	transmembrane signaling receptor activity
MTO69_RS15800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MTO69_RS15825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MTO69_RS15835	COG0259	pyridoxamine-phosphate oxidase activity
MTO69_RS15865	COG3033	Beta-eliminating lyase
MTO69_RS15870	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MTO69_RS15875	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MTO69_RS15880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTO69_RS15890	COG1999	signal sequence binding
MTO69_RS15900	COG1162	GTPase activity
MTO69_RS15905	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MTO69_RS15915	COG0363	glucosamine-6-phosphate deaminase activity
MTO69_RS15925	COG4533	DNA binding
MTO69_RS15935	COG4176	ABC-type proline glycine betaine transport system permease component
MTO69_RS15940	COG3448	diguanylate cyclase activity
MTO69_RS15940	COG4175	Glycine betaine
MTO69_RS15945	COG1472	Belongs to the glycosyl hydrolase 3 family
MTO69_RS15950	COG4977	sequence-specific DNA binding
MTO69_RS15955	COG4580	involved in the transport of maltose and maltodextrins
MTO69_RS15965	COG1609	Transcriptional regulator
MTO69_RS15975	COG4166	transmembrane transport
MTO69_RS15985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO69_RS15995	COG4608	Belongs to the ABC transporter superfamily
MTO69_RS16010	COG2203	Gaf domain
MTO69_RS16010	COG2199	diguanylate cyclase activity
MTO69_RS16020	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MTO69_RS16040	COG0561	phosphatase activity
MTO69_RS16045	COG0346	lactoylglutathione lyase activity
MTO69_RS16075	COG0488	(ABC) transporter
MTO69_RS16080	COG0348	domain, Protein
MTO69_RS16085	COG0437	4 iron, 4 sulfur cluster binding
MTO69_RS16090	COG3383	formate dehydrogenase (NAD+) activity
MTO69_RS16095	COG2226	methyltransferase
MTO69_RS16125	COG2814	Major facilitator Superfamily
MTO69_RS16135	COG1960	acyl-CoA dehydrogenase activity
MTO69_RS16145	COG1012	belongs to the aldehyde dehydrogenase family
MTO69_RS16150	COG3384	dioxygenase
MTO69_RS16155	COG0679	Auxin Efflux Carrier
MTO69_RS16165	COG1012	belongs to the aldehyde dehydrogenase family
MTO69_RS16185	COG3971	2-oxopent-4-enoate hydratase activity
MTO69_RS16205	COG1846	Transcriptional regulator
MTO69_RS16220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MTO69_RS16225	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MTO69_RS16255	COG1671	Belongs to the UPF0178 family
MTO69_RS16260	COG0393	Putative heavy-metal-binding
MTO69_RS16270	COG1280	lysine exporter protein (LysE YggA)
MTO69_RS16275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MTO69_RS16280	COG1301	dicarboxylic acid transport
MTO69_RS16290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MTO69_RS16300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MTO69_RS16305	COG2169	Transcriptional regulator
MTO69_RS16315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MTO69_RS16335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MTO69_RS16360	COG1309	transcriptional regulator
MTO69_RS16365	COG3845	ABC transporter
MTO69_RS16370	COG4603	Belongs to the binding-protein-dependent transport system permease family
MTO69_RS16375	COG1079	Belongs to the binding-protein-dependent transport system permease family
MTO69_RS16390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MTO69_RS16410	COG0402	S-adenosylhomocysteine deaminase activity
MTO69_RS16420	COG1929	Belongs to the glycerate kinase type-1 family
MTO69_RS16425	COG2610	gluconate transmembrane transporter activity
MTO69_RS16435	COG1846	Transcriptional regulator
MTO69_RS16475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MTO69_RS16480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MTO69_RS16530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MTO69_RS16535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MTO69_RS16540	COG1028	Short-chain dehydrogenase reductase Sdr
MTO69_RS16545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MTO69_RS16550	COG1278	Cold shock
MTO69_RS16560	COG3122	Protein conserved in bacteria
MTO69_RS16565	COG1166	arginine decarboxylase activity
MTO69_RS16570	COG0010	Belongs to the arginase family
MTO69_RS16590	COG1760	l-serine dehydratase
MTO69_RS16600	COG2814	Major facilitator Superfamily
MTO69_RS16615	COG1609	Transcriptional regulator
MTO69_RS16620	COG1902	pentaerythritol trinitrate reductase activity
MTO69_RS16630	COG2814	Major facilitator Superfamily
MTO69_RS16650	COG2197	response regulator
MTO69_RS16655	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MTO69_RS16660	COG0583	DNA-binding transcription factor activity
MTO69_RS16665	COG0589	response to stress
MTO69_RS16670	COG1320	monovalent cation:proton antiporter activity
MTO69_RS16675	COG2212	antiporter activity
MTO69_RS16680	COG1863	multisubunit Na H antiporter MnhE subunit
MTO69_RS16685	COG0651	ATP synthesis coupled electron transport
MTO69_RS16690	COG1006	Multisubunit Na H antiporter MnhC subunit
MTO69_RS16695	COG2111	Na H antiporter
MTO69_RS16695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MTO69_RS16700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MTO69_RS16705	COG0471	metal ion transport
MTO69_RS16725	COG3788	relative of glutathione S-transferase, MAPEG superfamily
MTO69_RS16740	COG0671	phosphoesterase, PA-phosphatase related
MTO69_RS16745	COG3706	GGDEF domain
MTO69_RS16750	COG0351	phosphomethylpyrimidine kinase
MTO69_RS16755	COG0583	DNA-binding transcription factor activity
MTO69_RS16780	COG2723	6-phospho-beta-galactosidase activity
MTO69_RS16785	COG0589	response to stress
MTO69_RS16790	COG3706	GGDEF domain
MTO69_RS16795	COG0840	transmembrane signaling receptor activity
MTO69_RS16810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MTO69_RS16825	COG0583	DNA-binding transcription factor activity
MTO69_RS16865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MTO69_RS16870	COG0840	transmembrane signaling receptor activity
MTO69_RS16875	COG0835	chemotaxis
MTO69_RS16880	COG0835	chemotaxis
MTO69_RS16900	COG1444	tRNA N-acetyltransferase activity
MTO69_RS16935	COG0217	transcriptional regulatory protein
MTO69_RS16960	COG3842	ATPase activity
MTO69_RS16965	COG0395	ABC-type sugar transport system, permease component
MTO69_RS16970	COG1175	transmembrane transport
MTO69_RS16975	COG1653	transport
MTO69_RS16980	COG1609	Transcriptional regulator
MTO69_RS16985	COG0366	Alpha amylase catalytic
MTO69_RS16990	COG0583	DNA-binding transcription factor activity
MTO69_RS17020	COG0583	DNA-binding transcription factor activity
MTO69_RS17045	COG2188	Transcriptional regulator
MTO69_RS17050	COG1131	(ABC) transporter
MTO69_RS17065	COG0840	transmembrane signaling receptor activity
MTO69_RS17090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MTO69_RS17095	COG3639	organic phosphonate transmembrane transporter activity
MTO69_RS17100	COG3639	organic phosphonate transmembrane transporter activity
MTO69_RS17115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MTO69_RS17120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MTO69_RS17155	COG2909	trisaccharide binding
MTO69_RS17160	COG0058	SHG alpha-glucan phosphorylase activity
MTO69_RS17165	COG1640	4-alpha-glucanotransferase
MTO69_RS17170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MTO69_RS17190	COG1741	Belongs to the pirin family
MTO69_RS17205	COG1132	(ABC) transporter
MTO69_RS17235	COG4264	IucA IucC family
MTO69_RS17245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTO69_RS17250	COG1120	ATPase activity
MTO69_RS17285	COG1247	-acetyltransferase
MTO69_RS17295	COG0673	inositol 2-dehydrogenase activity
MTO69_RS17340	COG0671	phosphoesterase, PA-phosphatase related
MTO69_RS17345	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MTO69_RS17350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MTO69_RS17355	COG0459	protein refolding
MTO69_RS17380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MTO69_RS17395	COG0415	Belongs to the DNA photolyase family
MTO69_RS17400	COG3046	protein related to deoxyribodipyrimidine photolyase
MTO69_RS17410	COG2329	Antibiotic biosynthesis monooxygenase
MTO69_RS17420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTO69_RS17445	COG4580	involved in the transport of maltose and maltodextrins
MTO69_RS17480	COG1280	lysine exporter protein (LysE YggA)
MTO69_RS17495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTO69_RS17505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MTO69_RS17510	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MTO69_RS17535	COG1612	heme a metabolic process
MTO69_RS17540	COG0109	protoheme IX farnesyltransferase activity
MTO69_RS17545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MTO69_RS17550	COG0366	Alpha amylase catalytic
MTO69_RS17565	COG0668	transmembrane transport
MTO69_RS17575	COG3123	guanosine phosphorylase activity
MTO69_RS17625	COG0471	metal ion transport
MTO69_RS17625	COG0490	domain, Protein
MTO69_RS17650	COG3501	Rhs element vgr protein
MTO69_RS17650	COG3409	Peptidoglycan-binding domain 1 protein
MTO69_RS17675	COG0366	Alpha amylase catalytic
MTO69_RS17695	COG0509	glycine decarboxylation via glycine cleavage system
MTO69_RS17700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MTO69_RS17710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MTO69_RS17730	COG1869	D-ribose catabolic process
MTO69_RS17735	COG1129	ABC transporter
MTO69_RS17740	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTO69_RS17745	COG1879	ABC-type sugar transport system periplasmic component
MTO69_RS17750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTO69_RS17755	COG1609	Transcriptional regulator
MTO69_RS17760	COG0835	chemotaxis
MTO69_RS17760	COG0784	Response regulator, receiver
MTO69_RS17765	COG0513	Belongs to the DEAD box helicase family
MTO69_RS17770	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
MTO69_RS17780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MTO69_RS17785	COG3842	ATPase activity
MTO69_RS17795	COG1175	transmembrane transport
MTO69_RS17800	COG3833	ABC-type maltose transport systems, permease component
MTO69_RS17840	COG0861	Integral membrane protein TerC family
MTO69_RS17845	COG2239	Acts as a magnesium transporter
MTO69_RS17850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MTO69_RS17855	COG0531	amino acid
MTO69_RS17875	COG0673	inositol 2-dehydrogenase activity
MTO69_RS17880	COG1765	OsmC-like protein
MTO69_RS17905	COG2304	oxidoreductase activity
MTO69_RS17925	COG0714	Associated with various cellular activities
MTO69_RS17940	COG0418	dihydroorotase activity
MTO69_RS17945	COG0401	homolog of Blt101
MTO69_RS17950	COG3217	Mosc domain protein beta barrel domain protein
MTO69_RS17950	COG0633	Ferredoxin
MTO69_RS17950	COG0633	Ferredoxin
MTO69_RS17950	COG3217	Mosc domain protein beta barrel domain protein
MTO69_RS17970	COG2354	Protein conserved in bacteria
MTO69_RS17980	COG0366	Alpha amylase catalytic
MTO69_RS17985	COG0840	transmembrane signaling receptor activity
MTO69_RS18025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MTO69_RS18025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MTO69_RS18040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MTO69_RS18045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MTO69_RS18080	COG2801	Transposase and inactivated derivatives
MTO69_RS18105	COG2801	Transposase and inactivated derivatives
MTO69_RS18110	COG2026	Addiction module toxin, RelE StbE family
MTO69_RS18135	COG2801	Transposase and inactivated derivatives
MTO69_RS18160	COG2801	Transposase and inactivated derivatives
MTO69_RS18180	COG2801	Transposase and inactivated derivatives
MTO69_RS18185	COG0456	acetyltransferase
MTO69_RS18215	COG2801	Transposase and inactivated derivatives
MTO69_RS18245	COG2801	Transposase and inactivated derivatives
MTO69_RS18285	COG4589	Belongs to the CDS family
MTO69_RS18305	COG0678	peroxiredoxin activity
MTO69_RS18310	COG2824	Alkylphosphonate utilization operon protein PhnA
MTO69_RS18340	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MTO69_RS18355	COG1805	sodium ion transport
MTO69_RS18380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MTO69_RS18405	COG1309	transcriptional regulator
MTO69_RS18430	COG0625	glutathione transferase activity
MTO69_RS18435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MTO69_RS18440	COG0366	Alpha amylase catalytic
MTO69_RS18445	COG2084	Dehydrogenase
MTO69_RS18455	COG2130	NADP-dependent
MTO69_RS18460	COG1309	transcriptional regulator
MTO69_RS18470	COG0513	Belongs to the DEAD box helicase family
MTO69_RS18480	COG0564	pseudouridine synthase activity
MTO69_RS18495	COG0840	transmembrane signaling receptor activity
MTO69_RS18500	COG0516	GMP reductase activity
MTO69_RS18505	COG4974	Belongs to the 'phage' integrase family
MTO69_RS18525	COG1566	PFAM secretion protein HlyD family protein
MTO69_RS18550	COG1309	transcriptional regulator
MTO69_RS18575	COG4175	Glycine betaine
MTO69_RS18575	COG0517	IMP dehydrogenase activity
MTO69_RS18600	COG1012	belongs to the aldehyde dehydrogenase family
MTO69_RS18605	COG3284	Transcriptional regulator
MTO69_RS18615	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MTO69_RS18620	COG0363	glucosamine-6-phosphate deaminase activity
MTO69_RS18625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MTO69_RS18660	COG0156	8-amino-7-oxononanoate synthase activity
MTO69_RS18665	COG1063	alcohol dehydrogenase
MTO69_RS18675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MTO69_RS18720	COG0612	Peptidase, M16
MTO69_RS18735	COG1304	FMN binding
MTO69_RS18740	COG1620	l-lactate permease
MTO69_RS18745	COG0583	DNA-binding transcription factor activity
MTO69_RS18750	COG1067	ATP-dependent peptidase activity
MTO69_RS18765	COG4166	transmembrane transport
MTO69_RS18770	COG4174	ABC transporter (Permease)
MTO69_RS18775	COG4239	(ABC) transporter, permease
MTO69_RS18780	COG4172	Belongs to the ABC transporter superfamily
MTO69_RS18790	COG5001	Diguanylate cyclase
MTO69_RS18805	COG0789	Transcriptional regulator
MTO69_RS18815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MTO69_RS18830	COG5002	protein histidine kinase activity
MTO69_RS18835	COG0745	RESPONSE REGULATOR receiver
MTO69_RS18840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MTO69_RS18845	COG2194	sulfuric ester hydrolase activity
MTO69_RS18860	COG3706	GGDEF domain