locus-tag	class	description
ITG12_RS00005	COG1074	ATP-dependent DNA helicase activity
ITG12_RS00065	COG3850	Histidine kinase
ITG12_RS00065	COG5002	protein histidine kinase activity
ITG12_RS00070	COG0745	RESPONSE REGULATOR receiver
ITG12_RS00075	COG0463	Glycosyl transferase, family 2
ITG12_RS00080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ITG12_RS00090	COG0840	transmembrane signaling receptor activity
ITG12_RS00095	COG2964	Protein conserved in bacteria
ITG12_RS00110	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG12_RS00135	COG1032	radical SAM domain protein
ITG12_RS00140	COG1716	ATPase activity
ITG12_RS00140	COG5001	Diguanylate cyclase
ITG12_RS00155	COG0583	DNA-binding transcription factor activity
ITG12_RS00160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ITG12_RS00170	COG2350	Protein conserved in bacteria
ITG12_RS00175	COG1607	acyl-coa hydrolase
ITG12_RS00200	COG1301	dicarboxylic acid transport
ITG12_RS00210	COG0159	tryptophan synthase activity
ITG12_RS00220	COG0135	phosphoribosylanthranilate isomerase activity
ITG12_RS00220	COG0134	indole-3-glycerol-phosphate synthase activity
ITG12_RS00230	COG0512	Glutamine amidotransferase of anthranilate synthase
ITG12_RS00235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG12_RS00245	COG0613	PHP domain protein
ITG12_RS00250	COG0009	L-threonylcarbamoyladenylate synthase
ITG12_RS00260	COG1187	pseudouridine synthase activity
ITG12_RS00280	COG0417	DNA replication proofreading
ITG12_RS00285	COG2197	response regulator
ITG12_RS00290	COG0322	excinuclease ABC activity
ITG12_RS00330	COG0019	diaminopimelate decarboxylase activity
ITG12_RS00360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG12_RS00365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG12_RS00370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG12_RS00390	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ITG12_RS00400	COG0437	4 iron, 4 sulfur cluster binding
ITG12_RS00405	COG3301	Polysulphide reductase, NrfD
ITG12_RS00410	COG1138	Cytochrome C-type biogenesis protein
ITG12_RS00420	COG3088	subunit of a heme lyase
ITG12_RS00420	COG4235	cytochrome complex assembly
ITG12_RS00430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG12_RS00455	COG2989	Protein conserved in bacteria
ITG12_RS00460	COG3108	Peptidase M15
ITG12_RS00465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITG12_RS00480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ITG12_RS00505	COG1846	Transcriptional regulator
ITG12_RS00510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_RS00515	COG0840	transmembrane signaling receptor activity
ITG12_RS00535	COG1448	Aminotransferase
ITG12_RS00540	COG3437	response regulator, receiver
ITG12_RS00540	COG2770	Histidine kinase
ITG12_RS00545	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG12_RS00555	COG1609	Transcriptional regulator
ITG12_RS00575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG12_RS00590	COG0017	Asparaginyl-tRNA synthetase
ITG12_RS00600	COG0720	synthase
ITG12_RS00605	COG2197	response regulator
ITG12_RS00620	COG3300	MHYT domain
ITG12_RS00620	COG5001	Diguanylate cyclase
ITG12_RS00625	COG1760	l-serine dehydratase
ITG12_RS00630	COG0814	amino acid
ITG12_RS00635	COG0494	nUDIX hydrolase
ITG12_RS00645	COG2205	protein histidine kinase activity
ITG12_RS00645	COG0784	Response regulator, receiver
ITG12_RS00650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG12_RS00665	COG3106	COG3106 Predicted ATPase
ITG12_RS00680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG12_RS00770	COG2026	Addiction module toxin, RelE StbE family
ITG12_RS00800	COG0251	oxidation-reduction process
ITG12_RS01495	COG2026	Addiction module toxin, RelE StbE family
ITG12_RS01525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ITG12_RS01730	COG3738	Protein conserved in bacteria
ITG12_RS01735	COG3340	Belongs to the peptidase S51 family
ITG12_RS01755	COG0456	acetyltransferase
ITG12_RS01760	COG0471	metal ion transport
ITG12_RS01765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG12_RS01765	COG4191	Histidine kinase
ITG12_RS01775	COG5001	Diguanylate cyclase
ITG12_RS01775	COG3300	MHYT domain
ITG12_RS01785	COG1280	lysine exporter protein (LysE YggA)
ITG12_RS01790	COG1328	CTP reductase activity
ITG12_RS01795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG12_RS01805	COG0861	Integral membrane protein TerC family
ITG12_RS01815	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG12_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS01825	COG3706	GGDEF domain
ITG12_RS01840	COG0814	amino acid
ITG12_RS01855	COG1120	ATPase activity
ITG12_RS01860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG12_RS01870	COG4774	siderophore transport
ITG12_RS01880	COG1132	(ABC) transporter
ITG12_RS01885	COG1132	(ABC) transporter
ITG12_RS01890	COG2165	general secretion pathway protein
ITG12_RS01895	COG0583	DNA-binding transcription factor activity
ITG12_RS01920	COG0443	Heat shock 70 kDa protein
ITG12_RS01925	COG0443	Heat shock 70 kDa protein
ITG12_RS01965	COG3227	Zinc metalloprotease (Elastase)
ITG12_RS01975	COG0243	molybdopterin cofactor binding
ITG12_RS01980	COG0437	4 iron, 4 sulfur cluster binding
ITG12_RS01985	COG3302	dmso reductase anchor subunit
ITG12_RS02000	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ITG12_RS02005	COG1643	Atp-dependent helicase
ITG12_RS02030	COG3063	Type IV pilus biogenesis stability protein PilW
ITG12_RS02035	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ITG12_RS02065	COG0531	amino acid
ITG12_RS02070	COG1280	lysine exporter protein (LysE YggA)
ITG12_RS02075	COG0583	DNA-binding transcription factor activity
ITG12_RS02080	COG1560	Kdo2-lipid A biosynthetic process
ITG12_RS02095	COG1846	Transcriptional regulator
ITG12_RS02110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ITG12_RS02115	COG1280	lysine exporter protein (LysE YggA)
ITG12_RS02150	COG1115	amino acid carrier protein
ITG12_RS02180	COG1368	sulfuric ester hydrolase activity
ITG12_RS02185	COG0215	cysteine-tRNA ligase activity
ITG12_RS02190	COG0534	Mate efflux family protein
ITG12_RS02195	COG2113	Glycine betaine
ITG12_RS02200	COG4176	ABC-type proline glycine betaine transport system permease component
ITG12_RS02210	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ITG12_RS02220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_RS02225	COG0456	acetyltransferase
ITG12_RS02230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ITG12_RS02235	COG0662	Cupin 2, conserved barrel domain protein
ITG12_RS02240	COG0527	aspartate kinase activity
ITG12_RS02245	COG1858	cytochrome C peroxidase
ITG12_RS02250	COG1404	Belongs to the peptidase S8 family
ITG12_RS02280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ITG12_RS02285	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ITG12_RS02295	COG2814	Major facilitator Superfamily
ITG12_RS02300	COG0583	DNA-binding transcription factor activity
ITG12_RS02310	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG12_RS02320	COG1595	DNA-templated transcription, initiation
ITG12_RS02325	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITG12_RS02330	COG2918	glutathione biosynthetic process
ITG12_RS02335	COG1132	(ABC) transporter
ITG12_RS02340	COG1132	(ABC) transporter
ITG12_RS02360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_RS02375	COG3976	FMN-binding domain protein
ITG12_RS02375	COG1053	succinate dehydrogenase
ITG12_RS02375	COG0431	NADPH-dependent FMN reductase
ITG12_RS02395	COG3290	protein histidine kinase activity
ITG12_RS02400	COG4565	transcriptional regulatory protein
ITG12_RS02405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ITG12_RS02410	COG0363	glucosamine-6-phosphate deaminase activity
ITG12_RS02415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITG12_RS02450	COG3284	Transcriptional regulator
ITG12_RS02455	COG1012	belongs to the aldehyde dehydrogenase family
ITG12_RS02465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_RS02470	COG2358	TRAP transporter, solute receptor (TAXI family
ITG12_RS02480	COG0814	amino acid
ITG12_RS02490	COG0730	response to heat
ITG12_RS02515	COG0456	acetyltransferase
ITG12_RS02525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG12_RS02530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG12_RS02640	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ITG12_RS02645	COG0372	Belongs to the citrate synthase family
ITG12_RS02655	COG2828	Protein conserved in bacteria
ITG12_RS02680	COG0561	phosphatase activity
ITG12_RS02685	COG0602	queuosine metabolic process
ITG12_RS02695	COG3706	GGDEF domain
ITG12_RS02740	COG0840	transmembrane signaling receptor activity
ITG12_RS02745	COG1254	Belongs to the acylphosphatase family
ITG12_RS02750	COG2920	part of a sulfur-relay system
ITG12_RS02760	COG0670	Belongs to the BI1 family
ITG12_RS02765	COG1126	abc transporter atp-binding protein
ITG12_RS02770	COG0765	amino acid transport
ITG12_RS02775	COG4597	amino acid ABC transporter
ITG12_RS02780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG12_RS02795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG12_RS02820	COG3008	intermembrane lipid transfer
ITG12_RS02825	COG2995	paraquat-inducible protein a
ITG12_RS02830	COG1132	(ABC) transporter
ITG12_RS02835	COG1956	GAF domain-containing protein
ITG12_RS02840	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ITG12_RS02855	COG0308	aminopeptidase N
ITG12_RS02865	COG2902	Dehydrogenase
ITG12_RS02890	COG0488	(ABC) transporter
ITG12_RS02905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ITG12_RS02910	COG1067	ATP-dependent peptidase activity
ITG12_RS02915	COG3120	sequence-specific DNA binding
ITG12_RS02935	COG2801	Transposase and inactivated derivatives
ITG12_RS02950	COG0784	Response regulator, receiver
ITG12_RS02950	COG2205	protein histidine kinase activity
ITG12_RS02965	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG12_RS02980	COG2010	Cytochrome c
ITG12_RS02990	COG2217	Heavy metal translocating P-type atpase
ITG12_RS03005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG12_RS03010	COG0589	response to stress
ITG12_RS03035	COG3842	ATPase activity
ITG12_RS03045	COG1177	transmembrane transport
ITG12_RS03055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ITG12_RS03060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ITG12_RS03075	COG0437	4 iron, 4 sulfur cluster binding
ITG12_RS03080	COG0243	molybdopterin cofactor binding
ITG12_RS03080	COG3383	formate dehydrogenase (NAD+) activity
ITG12_RS03090	COG3381	protein complex oligomerization
ITG12_RS03110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ITG12_RS03115	COG0488	(ABC) transporter
ITG12_RS03130	COG4191	Histidine kinase
ITG12_RS03135	COG2204	response regulator
ITG12_RS03145	COG4662	Binding-protein-dependent transport system inner membrane component
ITG12_RS03150	COG3842	ATPase activity
ITG12_RS03160	COG0303	'Molybdopterin
ITG12_RS03170	COG1940	carbohydrate kinase activity
ITG12_RS03175	COG3148	PFAM DTW domain containing protein
ITG12_RS03220	COG0840	transmembrane signaling receptor activity
ITG12_RS03225	COG0791	NLP P60 protein
ITG12_RS03235	COG3706	GGDEF domain
ITG12_RS03240	COG2201	protein-glutamate methylesterase activity
ITG12_RS03245	COG3001	Fructosamine kinase
ITG12_RS03255	COG0307	riboflavin synthase, alpha
ITG12_RS03260	COG0534	Mate efflux family protein
ITG12_RS03270	COG1793	dna ligase
ITG12_RS03280	COG2885	chlorophyll binding
ITG12_RS03290	COG0489	protein tyrosine kinase activity
ITG12_RS03300	COG2204	response regulator
ITG12_RS03310	COG0438	transferase activity, transferring glycosyl groups
ITG12_RS03340	COG0438	transferase activity, transferring glycosyl groups
ITG12_RS03345	COG1215	transferase activity, transferring glycosyl groups
ITG12_RS03350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG12_RS03360	COG3064	Membrane
ITG12_RS03380	COG3300	MHYT domain
ITG12_RS03380	COG5001	Diguanylate cyclase
ITG12_RS03385	COG2205	protein histidine kinase activity
ITG12_RS03385	COG4999	Histidine kinase
ITG12_RS03385	COG3850	Histidine kinase
ITG12_RS03385	COG3437	response regulator, receiver
ITG12_RS03405	COG0110	maltose O-acetyltransferase activity
ITG12_RS03425	COG1846	Transcriptional regulator
ITG12_RS03440	COG2199	diguanylate cyclase activity
ITG12_RS03440	COG2202	Pas domain
ITG12_RS03440	COG2200	EAL domain
ITG12_RS03455	COG3247	response to pH
ITG12_RS03460	COG0668	transmembrane transport
ITG12_RS03480	COG2885	chlorophyll binding
ITG12_RS03480	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ITG12_RS03485	COG5492	domain, Protein
ITG12_RS03485	COG4932	domain protein
ITG12_RS03490	COG1404	Belongs to the peptidase S8 family
ITG12_RS03510	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ITG12_RS03590	COG0519	Catalyzes the synthesis of GMP from XMP
ITG12_RS03600	COG0297	glycogen (starch) synthase activity
ITG12_RS03610	COG0668	transmembrane transport
ITG12_RS03630	COG1196	nuclear chromosome segregation
ITG12_RS03640	COG1401	restriction endodeoxyribonuclease activity
ITG12_RS03650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ITG12_RS03670	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ITG12_RS03740	COG0625	glutathione transferase activity
ITG12_RS03750	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ITG12_RS03765	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG12_RS03795	COG0813	purine-nucleoside phosphorylase activity
ITG12_RS03810	COG1451	nucleotide metabolic process
ITG12_RS03840	COG0583	DNA-binding transcription factor activity
ITG12_RS03870	COG4139	cobalamin transport
ITG12_RS03895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ITG12_RS03905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ITG12_RS03910	COG0702	epimerase
ITG12_RS03915	COG1823	symporter activity
ITG12_RS03925	COG2925	Exonuclease
ITG12_RS03935	COG1346	cytolysis
ITG12_RS03975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG12_RS03975	COG0072	phenylalanine-tRNA ligase activity
ITG12_RS04020	COG0251	oxidation-reduction process
ITG12_RS04035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ITG12_RS04055	COG2188	Transcriptional regulator
ITG12_RS04065	COG0010	Belongs to the arginase family
ITG12_RS04075	COG2986	histidine ammonia-lyase
ITG12_RS04120	COG0247	lactate metabolic process
ITG12_RS04120	COG0277	FAD linked oxidase domain protein
ITG12_RS04175	COG1643	Atp-dependent helicase
ITG12_RS04185	COG2949	membrane
ITG12_RS04190	COG0471	metal ion transport
ITG12_RS04195	COG3706	GGDEF domain
ITG12_RS04215	COG0492	ferredoxin-NADP+ reductase activity
ITG12_RS04220	COG4988	ABC transporter
ITG12_RS04225	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ITG12_RS04235	COG0583	DNA-binding transcription factor activity
ITG12_RS04240	COG2200	EAL domain
ITG12_RS04270	COG5001	Diguanylate cyclase
ITG12_RS04280	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ITG12_RS04290	COG4191	Histidine kinase
ITG12_RS04290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG12_RS04305	COG3070	regulator of competence-specific genes
ITG12_RS04315	COG2431	L-lysine efflux transmembrane transporter activity
ITG12_RS04325	COG0076	glutamate decarboxylase activity
ITG12_RS04330	COG1737	Transcriptional regulator
ITG12_RS04340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG12_RS04350	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG12_RS04385	COG0534	Mate efflux family protein
ITG12_RS04390	COG0702	epimerase
ITG12_RS04395	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG12_RS04405	COG2814	Major facilitator Superfamily
ITG12_RS04410	COG1187	pseudouridine synthase activity
ITG12_RS04415	COG1061	Type III restriction enzyme res subunit
ITG12_RS04420	COG3706	GGDEF domain
ITG12_RS04460	COG0454	-acetyltransferase
ITG12_RS04475	COG3313	Fe-S protein
ITG12_RS04485	COG0659	secondary active sulfate transmembrane transporter activity
ITG12_RS04510	COG0493	'glutamate synthase
ITG12_RS04520	COG0398	Pfam SNARE associated Golgi protein
ITG12_RS04525	COG4134	Bacterial extracellular solute-binding protein
ITG12_RS04530	COG4135	transport system, permease component
ITG12_RS04535	COG4136	ATPase activity
ITG12_RS04540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ITG12_RS04550	COG3604	Transcriptional regulator
ITG12_RS04555	COG1151	hydroxylamine reductase activity
ITG12_RS04560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG12_RS04570	COG0564	pseudouridine synthase activity
ITG12_RS04580	COG0733	neurotransmitter:sodium symporter activity
ITG12_RS04590	COG0626	cystathionine gamma-synthase activity
ITG12_RS04595	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ITG12_RS04600	COG5380	lipid catabolic process
ITG12_RS04605	COG2818	Glycosylase
ITG12_RS04615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_RS04635	COG1842	Phage shock protein A
ITG12_RS04640	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ITG12_RS04650	COG4168	peptide transport system, permease
ITG12_RS04655	COG4171	peptide transport system, permease
ITG12_RS04665	COG4172	Belongs to the ABC transporter superfamily
ITG12_RS04675	COG1227	inorganic diphosphatase activity
ITG12_RS04680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG12_RS04685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG12_RS04690	COG1121	(ABC) transporter
ITG12_RS04705	COG0243	molybdopterin cofactor binding
ITG12_RS04710	COG3005	denitrification pathway
ITG12_RS04715	COG4459	periplasmic nitrate reductase
ITG12_RS04720	COG0390	transport system, permease component
ITG12_RS04730	COG2116	formate transmembrane transporter activity
ITG12_RS04755	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ITG12_RS04760	COG1435	thymidine kinase activity
ITG12_RS04765	COG0215	cysteine-tRNA ligase activity
ITG12_RS04770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG12_RS04775	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG12_RS04780	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG12_RS04785	COG3012	SEC-C Motif Domain Protein
ITG12_RS04790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ITG12_RS04790	COG0140	phosphoribosyl-ATP diphosphatase activity
ITG12_RS04800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ITG12_RS04805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ITG12_RS04810	COG0131	Imidazoleglycerol-phosphate dehydratase
ITG12_RS04810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG12_RS04820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ITG12_RS04830	COG1757	Na H antiporter
ITG12_RS04840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_RS04860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ITG12_RS04880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ITG12_RS04895	COG0300	oxidoreductase activity
ITG12_RS04940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ITG12_RS04960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ITG12_RS04970	COG1674	ftsk spoiiie
ITG12_RS04980	COG0686	Belongs to the AlaDH PNT family
ITG12_RS04990	COG0583	DNA-binding transcription factor activity
ITG12_RS05005	COG2801	Transposase and inactivated derivatives
ITG12_RS05065	COG4934	collagen metabolic process
ITG12_RS05085	COG3568	Endonuclease Exonuclease Phosphatase
ITG12_RS05110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITG12_RS05125	COG0800	Aldolase
ITG12_RS05130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_RS05135	COG1917	Cupin 2, conserved barrel domain protein
ITG12_RS05160	COG2186	Transcriptional regulator
ITG12_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS05170	COG2186	Transcriptional regulator
ITG12_RS05175	COG0517	IMP dehydrogenase activity
ITG12_RS05180	COG2176	DNA-directed DNA polymerase activity
ITG12_RS05190	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ITG12_RS05205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG12_RS05235	COG1288	antiporter activity
ITG12_RS05245	COG2186	Transcriptional regulator
ITG12_RS05255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_RS05260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_RS05295	COG4608	Belongs to the ABC transporter superfamily
ITG12_RS05300	COG0444	Belongs to the ABC transporter superfamily
ITG12_RS05305	COG0534	Mate efflux family protein
ITG12_RS05320	COG2824	Alkylphosphonate utilization operon protein PhnA
ITG12_RS05325	COG2723	6-phospho-beta-galactosidase activity
ITG12_RS05330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_RS05330	COG1263	PTS System
ITG12_RS05335	COG3119	arylsulfatase activity
ITG12_RS05355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG12_RS05375	COG0457	Tetratricopeptide repeat
ITG12_RS05445	COG4790	Type iii secretion
ITG12_RS05450	COG4794	Type iii secretion
ITG12_RS05455	COG4791	protein targeting
ITG12_RS05460	COG4792	protein secretion
ITG12_RS05475	COG3177	Filamentation induced by cAMP protein fic
ITG12_RS05495	COG4669	(LipO)protein
ITG12_RS05625	COG5002	protein histidine kinase activity
ITG12_RS05625	COG0784	Response regulator, receiver
ITG12_RS05635	COG0754	glutathionylspermidine amidase activity
ITG12_RS05645	COG3766	membrane
ITG12_RS05660	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ITG12_RS05665	COG2885	chlorophyll binding
ITG12_RS05670	COG0823	Involved in the tonB-independent uptake of proteins
ITG12_RS05685	COG0811	peptide transport
ITG12_RS05690	COG0824	Thioesterase
ITG12_RS05700	COG4890	Cyd operon protein YbgT
ITG12_RS05705	COG1294	oxidase, subunit
ITG12_RS05710	COG1271	oxidase subunit
ITG12_RS05720	COG0632	four-way junction helicase activity
ITG12_RS05725	COG0840	transmembrane signaling receptor activity
ITG12_RS05735	COG0217	transcriptional regulatory protein
ITG12_RS05745	COG1801	Protein of unknown function DUF72
ITG12_RS05760	COG4067	protein conserved in archaea
ITG12_RS05760	COG0189	ligase activity
ITG12_RS05785	COG0318	PFAM AMP-dependent synthetase and ligase
ITG12_RS05800	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ITG12_RS05805	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ITG12_RS05810	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ITG12_RS05815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG12_RS05820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ITG12_RS05825	COG0745	RESPONSE REGULATOR receiver
ITG12_RS05840	COG3070	regulator of competence-specific genes
ITG12_RS05860	COG0297	glycogen (starch) synthase activity
ITG12_RS05865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG12_RS05870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG12_RS05900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ITG12_RS05905	COG0542	response to heat
ITG12_RS05915	COG1278	Cold shock
ITG12_RS05925	COG1187	pseudouridine synthase activity
ITG12_RS05930	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG12_RS05940	COG1199	ATP-dependent helicase activity
ITG12_RS05945	COG0730	response to heat
ITG12_RS05950	COG3923	Primosomal replication protein n
ITG12_RS05960	COG0708	Exodeoxyribonuclease III
ITG12_RS05970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_RS06010	COG1882	Formate acetyltransferase
ITG12_RS06020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG12_RS06035	COG2766	serine protein kinase
ITG12_RS06040	COG2718	Belongs to the UPF0229 family
ITG12_RS06045	COG2719	SpoVR family
ITG12_RS06065	COG1132	(ABC) transporter
ITG12_RS06070	COG0658	competence protein
ITG12_RS06070	COG2333	competence protein COMEC
ITG12_RS06080	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG12_RS06085	COG1136	(ABC) transporter
ITG12_RS06090	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG12_RS06100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ITG12_RS06115	COG1252	NADH dehydrogenase
ITG12_RS06145	COG0537	adenosine 5'-monophosphoramidase activity
ITG12_RS06175	COG0517	IMP dehydrogenase activity
ITG12_RS06175	COG0516	GMP reductase activity
ITG12_RS06180	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ITG12_RS06185	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ITG12_RS06190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG12_RS06195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ITG12_RS06205	COG2199	diguanylate cyclase activity
ITG12_RS06220	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ITG12_RS06225	COG1946	Acyl-CoA thioesterase
ITG12_RS06235	COG1522	sequence-specific DNA binding
ITG12_RS06255	COG2801	Transposase and inactivated derivatives
ITG12_RS06260	COG2963	transposase activity
ITG12_RS06265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_RS06270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_RS06320	COG2855	membrane
ITG12_RS06330	COG0583	DNA-binding transcription factor activity
ITG12_RS06335	COG2190	(PTS) system
ITG12_RS06335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_RS06335	COG1263	PTS System
ITG12_RS06350	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ITG12_RS06355	COG0596	Alpha beta hydrolase
ITG12_RS06365	COG1169	isochorismate synthase
ITG12_RS06370	COG0436	Aminotransferase
ITG12_RS06375	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ITG12_RS06395	COG1555	photosystem II stabilization
ITG12_RS06400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG12_RS06405	COG0776	regulation of translation
ITG12_RS06410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ITG12_RS06445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG12_RS06450	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG12_RS06455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG12_RS06475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG12_RS06480	COG0569	domain protein
ITG12_RS06485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_RS06490	COG0513	Belongs to the DEAD box helicase family
ITG12_RS06495	COG1253	flavin adenine dinucleotide binding
ITG12_RS06500	COG4771	TonB-dependent receptor
ITG12_RS06515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITG12_RS06515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITG12_RS06520	COG3433	isochorismatase activity
ITG12_RS06520	COG1535	isochorismatase
ITG12_RS06525	COG1021	2,3-dihydroxybenzoate-AMP ligase
ITG12_RS06530	COG1169	isochorismate synthase
ITG12_RS06540	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS06550	COG2391	methyltransferase activity
ITG12_RS06655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG12_RS06660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG12_RS06670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG12_RS06680	COG1216	Glycosyl transferase, family 2
ITG12_RS06685	COG2986	histidine ammonia-lyase
ITG12_RS06720	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS06740	COG2852	Protein conserved in bacteria
ITG12_RS06745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG12_RS06755	COG2951	lytic endotransglycosylase activity
ITG12_RS06770	COG2894	cell division
ITG12_RS06775	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ITG12_RS06780	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ITG12_RS06785	COG0318	PFAM AMP-dependent synthetase and ligase
ITG12_RS06790	COG2267	carboxylic ester hydrolase activity
ITG12_RS06795	COG3065	identical protein binding
ITG12_RS06805	COG1214	PFAM Peptidase M22, glycoprotease
ITG12_RS06810	COG1199	ATP-dependent helicase activity
ITG12_RS06815	COG0788	formyltetrahydrofolate deformylase activity
ITG12_RS06820	COG3102	Protein conserved in bacteria
ITG12_RS06850	COG1918	ferrous iron import across plasma membrane
ITG12_RS06855	COG4977	sequence-specific DNA binding
ITG12_RS06860	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ITG12_RS06865	COG1121	(ABC) transporter
ITG12_RS06870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG12_RS06875	COG2801	Transposase and inactivated derivatives
ITG12_RS06880	COG2963	transposase activity
ITG12_RS06895	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG12_RS06900	COG0567	Dehydrogenase, E1 component
ITG12_RS06910	COG1053	succinate dehydrogenase
ITG12_RS06915	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ITG12_RS06930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ITG12_RS06940	COG0033	Phosphoglucomutase
ITG12_RS06945	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ITG12_RS06950	COG0596	Alpha beta hydrolase
ITG12_RS06970	COG0735	belongs to the Fur family
ITG12_RS06975	COG2165	general secretion pathway protein
ITG12_RS06985	COG1263	PTS System
ITG12_RS06985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_RS06985	COG2190	(PTS) system
ITG12_RS06990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ITG12_RS06995	COG1940	carbohydrate kinase activity
ITG12_RS06995	COG1846	Transcriptional regulator
ITG12_RS07000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG12_RS07000	COG4651	solute:proton antiporter activity
ITG12_RS07005	COG0367	asparagine synthase
ITG12_RS07010	COG0250	Participates in transcription elongation, termination and antitermination
ITG12_RS07015	COG3104	oligopeptide transport
ITG12_RS07020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ITG12_RS07035	COG3710	Transcriptional regulator
ITG12_RS07055	COG0622	Phosphoesterase
ITG12_RS07085	COG1090	epimerase
ITG12_RS07090	COG0300	oxidoreductase activity
ITG12_RS07095	COG3118	belongs to the thioredoxin family
ITG12_RS07100	COG0457	Tetratricopeptide repeat
ITG12_RS07100	COG3118	belongs to the thioredoxin family
ITG12_RS07105	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ITG12_RS07110	COG1215	transferase activity, transferring glycosyl groups
ITG12_RS07115	COG1215	transferase activity, transferring glycosyl groups
ITG12_RS07140	COG2194	sulfuric ester hydrolase activity
ITG12_RS07145	COG0330	HflC and HflK could
ITG12_RS07175	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ITG12_RS07180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ITG12_RS07185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_RS07190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ITG12_RS07195	COG2190	(PTS) system
ITG12_RS07200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_RS07215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_RS07220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_RS07235	COG1705	Flagellar rod assembly protein muramidase FlgJ
ITG12_RS07235	COG3951	Flagellar rod assembly protein muramidase FlgJ
ITG12_RS07240	COG1706	bacterial-type flagellum-dependent cell motility
ITG12_RS07245	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ITG12_RS07255	COG4787	bacterial-type flagellum-dependent cell motility
ITG12_RS07260	COG1749	Flagellar hook protein flgE
ITG12_RS07270	COG1558	bacterial-type flagellum-dependent cell motility
ITG12_RS07275	COG1815	bacterial-type flagellum-dependent cell motility
ITG12_RS07280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ITG12_RS07285	COG0784	Response regulator, receiver
ITG12_RS07285	COG0835	chemotaxis
ITG12_RS07340	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG12_RS07350	COG2217	Heavy metal translocating P-type atpase
ITG12_RS07350	COG2608	mercury ion transmembrane transporter activity
ITG12_RS07395	COG1187	pseudouridine synthase activity
ITG12_RS07400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ITG12_RS07415	COG2912	Transglutaminase-like superfamily
ITG12_RS07420	COG3094	Invasion gene expression up-regulator, SirB
ITG12_RS07425	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG12_RS07450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ITG12_RS07565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG12_RS07575	COG1702	phosphate starvation-inducible protein PhoH
ITG12_RS07585	COG4535	Mg2 and Co2 transporter CorC
ITG12_RS07590	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ITG12_RS07595	COG2888	peptidyl-tyrosine sulfation
ITG12_RS07600	COG0495	leucyl-tRNA aminoacylation
ITG12_RS07605	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ITG12_RS07610	COG1466	dna polymerase III delta subunit
ITG12_RS07615	COG0799	negative regulation of ribosome biogenesis
ITG12_RS07620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ITG12_RS07625	COG0768	penicillin binding
ITG12_RS07630	COG0772	Belongs to the SEDS family
ITG12_RS07635	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ITG12_RS07640	COG1686	Belongs to the peptidase S11 family
ITG12_RS07660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ITG12_RS07665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITG12_RS07680	COG0366	Alpha amylase catalytic
ITG12_RS07685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_RS07685	COG1263	PTS System
ITG12_RS07695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG12_RS07700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ITG12_RS07705	COG2011	ABC-type metal ion transport system permease component
ITG12_RS07710	COG1464	Belongs to the NlpA lipoprotein family
ITG12_RS07720	COG0737	Belongs to the 5'-nucleotidase family
ITG12_RS07725	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ITG12_RS07750	COG1611	Belongs to the LOG family
ITG12_RS07765	COG2363	Small membrane protein
ITG12_RS07775	COG0583	DNA-binding transcription factor activity
ITG12_RS07790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ITG12_RS07800	COG0142	geranyltranstransferase activity
ITG12_RS07810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ITG12_RS07815	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ITG12_RS07840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG12_RS07840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG12_RS07845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ITG12_RS07850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ITG12_RS07865	COG1073	alpha beta
ITG12_RS07875	COG2252	PERMEase
ITG12_RS07880	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG12_RS07910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ITG12_RS07910	COG0047	phosphoribosylformylglycinamidine synthase activity
ITG12_RS07925	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG12_RS07965	COG1301	dicarboxylic acid transport
ITG12_RS07985	COG0497	DNA recombination
ITG12_RS07995	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG12_RS08005	COG2914	Belongs to the UPF0125 (RnfH) family
ITG12_RS08010	COG2867	negative regulation of translational initiation
ITG12_RS08025	COG0583	DNA-binding transcription factor activity
ITG12_RS08030	COG1289	transmembrane transporter activity
ITG12_RS08050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ITG12_RS08055	COG2873	o-acetylhomoserine
ITG12_RS08060	COG0668	transmembrane transport
ITG12_RS08075	COG0583	DNA-binding transcription factor activity
ITG12_RS08085	COG1115	amino acid carrier protein
ITG12_RS08090	COG1584	GPR1 FUN34 yaaH family protein
ITG12_RS08100	COG1757	Na H antiporter
ITG12_RS08110	COG0517	IMP dehydrogenase activity
ITG12_RS08110	COG0516	GMP reductase activity
ITG12_RS08125	COG2199	diguanylate cyclase activity
ITG12_RS08125	COG2203	Gaf domain
ITG12_RS08140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG12_RS08145	COG2976	Protein conserved in bacteria
ITG12_RS08180	COG2975	iron-sulfur cluster assembly
ITG12_RS08185	COG0633	Ferredoxin
ITG12_RS08200	COG0316	Belongs to the HesB IscA family
ITG12_RS08205	COG0822	iron-sulfur transferase activity
ITG12_RS08220	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ITG12_RS08225	COG0483	inositol monophosphate 1-phosphatase activity
ITG12_RS08240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG12_RS08245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG12_RS08250	COG1862	Preprotein translocase
ITG12_RS08255	COG0343	queuine tRNA-ribosyltransferase activity
ITG12_RS08260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ITG12_RS08275	COG0517	IMP dehydrogenase activity
ITG12_RS08285	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ITG12_RS08290	COG0583	DNA-binding transcription factor activity
ITG12_RS08295	COG0450	alkyl hydroperoxide reductase
ITG12_RS08325	COG0704	Plays a role in the regulation of phosphate uptake
ITG12_RS08330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG12_RS08335	COG0581	inorganic phosphate transmembrane transporter activity
ITG12_RS08340	COG0573	inorganic phosphate transmembrane transporter activity
ITG12_RS08345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ITG12_RS08350	COG0248	Ppx GppA phosphatase
ITG12_RS08360	COG5002	protein histidine kinase activity
ITG12_RS08365	COG0745	RESPONSE REGULATOR receiver
ITG12_RS08375	COG0826	peptidase U32
ITG12_RS08380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG12_RS08390	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ITG12_RS08435	COG0542	response to heat
ITG12_RS08440	COG1496	oxidoreductase activity
ITG12_RS08445	COG0564	pseudouridine synthase activity
ITG12_RS08450	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG12_RS08455	COG0741	lytic transglycosylase activity
ITG12_RS08460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG12_RS08465	COG0077	Prephenate dehydratase
ITG12_RS08465	COG1605	Chorismate mutase
ITG12_RS08470	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ITG12_RS08485	COG0488	(ABC) transporter
ITG12_RS08495	COG0739	heme binding
ITG12_RS08500	COG1605	Chorismate mutase
ITG12_RS08500	COG0287	Prephenate dehydrogenase
ITG12_RS08505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG12_RS08515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ITG12_RS08535	COG1966	Carbon starvation protein
ITG12_RS08540	COG3275	phosphorelay sensor kinase activity
ITG12_RS08545	COG3279	Response regulator of the LytR AlgR family
ITG12_RS08550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ITG12_RS08555	COG1047	Peptidyl-prolyl cis-trans
ITG12_RS08570	COG0196	riboflavin kinase activity
ITG12_RS08575	COG0728	peptidoglycan biosynthetic process
ITG12_RS08580	COG0268	Binds directly to 16S ribosomal RNA
ITG12_RS08585	COG0640	Transcriptional regulator
ITG12_RS08590	COG0583	DNA-binding transcription factor activity
ITG12_RS08595	COG1283	sodium-dependent phosphate transmembrane transporter activity
ITG12_RS08610	COG0730	response to heat
ITG12_RS08615	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ITG12_RS08635	COG0667	Aldo Keto reductase
ITG12_RS08660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ITG12_RS08665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG12_RS08670	COG4974	Belongs to the 'phage' integrase family
ITG12_RS08675	COG0716	FMN binding
ITG12_RS08685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ITG12_RS08690	COG0513	Belongs to the DEAD box helicase family
ITG12_RS08700	COG3022	response to hydroperoxide
ITG12_RS08705	COG1115	amino acid carrier protein
ITG12_RS08735	COG0431	NADPH-dependent FMN reductase
ITG12_RS08745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ITG12_RS08750	COG0083	homoserine kinase activity
ITG12_RS08765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG12_RS08775	COG0745	RESPONSE REGULATOR receiver
ITG12_RS08785	COG0784	Response regulator, receiver
ITG12_RS08785	COG2198	Histidine kinase
ITG12_RS08785	COG5002	protein histidine kinase activity
ITG12_RS08790	COG5001	Diguanylate cyclase
ITG12_RS08790	COG4251	negative regulation of phosphorylation
ITG12_RS08790	COG3706	GGDEF domain
ITG12_RS08790	COG2203	Gaf domain
ITG12_RS08795	COG1242	4 iron, 4 sulfur cluster binding
ITG12_RS08800	COG0070	glutamate synthase
ITG12_RS08800	COG0069	glutamate synthase activity
ITG12_RS08800	COG0067	glutamate synthase
ITG12_RS08810	COG0070	glutamate synthase
ITG12_RS08810	COG0067	glutamate synthase
ITG12_RS08810	COG0069	glutamate synthase activity
ITG12_RS08815	COG0493	'glutamate synthase
ITG12_RS08840	COG2860	membrane
ITG12_RS08845	COG0583	DNA-binding transcription factor activity
ITG12_RS08850	COG0730	response to heat
ITG12_RS08860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ITG12_RS08865	COG0505	Belongs to the CarA family
ITG12_RS08875	COG0494	nUDIX hydrolase
ITG12_RS08890	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ITG12_RS08895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ITG12_RS08900	COG0849	cell division
ITG12_RS08905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ITG12_RS08920	COG0772	Belongs to the SEDS family
ITG12_RS08935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ITG12_RS08940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ITG12_RS08945	COG0768	penicillin binding
ITG12_RS08950	COG3116	cell division
ITG12_RS08965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ITG12_RS08980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG12_RS08990	COG2969	positive regulation of protein catabolic process
ITG12_RS08995	COG0625	glutathione transferase activity
ITG12_RS09000	COG2857	Cytochrome c1
ITG12_RS09005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ITG12_RS09010	COG0723	plastoquinol--plastocyanin reductase activity
ITG12_RS09015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ITG12_RS09025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ITG12_RS09030	COG3105	Protein conserved in bacteria
ITG12_RS09040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITG12_RS09055	COG3150	esterase
ITG12_RS09065	COG3151	Protein conserved in bacteria
ITG12_RS09070	COG0494	nUDIX hydrolase
ITG12_RS09075	COG1538	Outer membrane efflux protein
ITG12_RS09085	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ITG12_RS09095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG12_RS09100	COG3025	triphosphatase activity
ITG12_RS09105	COG1392	Phosphate transport regulator
ITG12_RS09110	COG0306	phosphate transporter
ITG12_RS09115	COG4991	sh3 domain protein
ITG12_RS09120	COG0405	Gamma-glutamyltransferase
ITG12_RS09130	COG3409	Peptidoglycan-binding domain 1 protein
ITG12_RS09130	COG3267	Type II secretory pathway component ExeA
ITG12_RS09145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG12_RS09150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITG12_RS09160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ITG12_RS09165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ITG12_RS09170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ITG12_RS09175	COG1610	YqeY-like protein
ITG12_RS09180	COG0358	DNA primase activity
ITG12_RS09200	COG2963	transposase activity
ITG12_RS09225	COG2213	PTS system mannitol-specific
ITG12_RS09225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_RS09235	COG3722	fumarate hydratase activity
ITG12_RS09240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG12_RS09245	COG5002	protein histidine kinase activity
ITG12_RS09265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ITG12_RS09270	COG1349	DNA-binding transcription factor activity
ITG12_RS09275	COG0469	pyruvate kinase activity
ITG12_RS09285	COG3706	GGDEF domain
ITG12_RS09290	COG0440	acetolactate synthase activity
ITG12_RS09295	COG0028	Belongs to the TPP enzyme family
ITG12_RS09300	COG1022	Amp-dependent synthetase and ligase
ITG12_RS09305	COG0583	DNA-binding transcription factor activity
ITG12_RS09325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ITG12_RS09330	COG0473	3-isopropylmalate dehydrogenase activity
ITG12_RS09350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ITG12_RS09355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ITG12_RS09360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG12_RS09365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ITG12_RS09375	COG2967	ApaG domain
ITG12_RS09390	COG3610	response to peptide
ITG12_RS09395	COG2966	Psort location CytoplasmicMembrane, score
ITG12_RS09410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ITG12_RS09415	COG0142	geranyltranstransferase activity
ITG12_RS09435	COG2358	TRAP transporter, solute receptor (TAXI family
ITG12_RS09450	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ITG12_RS09455	COG1178	ABC-type Fe3 transport system permease component
ITG12_RS09460	COG4143	(ABC) transporter
ITG12_RS09465	COG0163	prenyltransferase activity
ITG12_RS09470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITG12_RS09480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ITG12_RS09495	COG2105	PFAM AIG2 family protein
ITG12_RS09500	COG2911	Protein conserved in bacteria
ITG12_RS09505	COG0729	surface antigen
ITG12_RS09510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_RS09520	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ITG12_RS09535	COG1136	(ABC) transporter
ITG12_RS09555	COG0529	Catalyzes the synthesis of activated sulfate
ITG12_RS09560	COG3273	potassium ion transport
ITG12_RS09560	COG0471	metal ion transport
ITG12_RS09570	COG0175	sulfate reduction
ITG12_RS09575	COG1648	precorrin-2 dehydrogenase activity
ITG12_RS09575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ITG12_RS09580	COG0737	Belongs to the 5'-nucleotidase family
ITG12_RS09595	COG0513	Belongs to the DEAD box helicase family
ITG12_RS09600	COG2153	protein acetylation
ITG12_RS09615	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG12_RS09625	COG0203	ribosomal protein L17
ITG12_RS09630	COG0202	RNA polymerase activity
ITG12_RS09640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ITG12_RS09645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ITG12_RS09650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ITG12_RS09655	COG0201	protein transport
ITG12_RS09660	COG0200	Binds to the 23S rRNA
ITG12_RS09665	COG1841	ribosomal large subunit assembly
ITG12_RS09705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ITG12_RS09735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ITG12_RS09750	COG0088	Forms part of the polypeptide exit tunnel
ITG12_RS09770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ITG12_RS09775	COG1609	Transcriptional regulator
ITG12_RS09795	COG1575	Belongs to the MenA family. Type 1 subfamily
ITG12_RS09800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG12_RS09805	COG3074	FtsZ-dependent cytokinesis
ITG12_RS09810	COG1494	fructose-1,6-bisphosphatase
ITG12_RS09840	COG0149	triose-phosphate isomerase activity
ITG12_RS09845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ITG12_RS09865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG12_RS09895	COG0438	transferase activity, transferring glycosyl groups
ITG12_RS09930	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG12_RS09935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ITG12_RS09940	COG1560	Kdo2-lipid A biosynthetic process
ITG12_RS09950	COG1519	Transferase
ITG12_RS09955	COG1083	cytidylyl-transferase
ITG12_RS09960	COG0483	inositol monophosphate 1-phosphatase activity
ITG12_RS09965	COG2089	acid synthase
ITG12_RS09980	COG2089	acid synthase
ITG12_RS09990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ITG12_RS09990	COG1181	Belongs to the D-alanine--D-alanine ligase family
ITG12_RS09995	COG0436	Aminotransferase
ITG12_RS10005	COG1083	cytidylyl-transferase
ITG12_RS10010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ITG12_RS10015	COG1086	Polysaccharide biosynthesis protein
ITG12_RS10020	COG3642	lipopolysaccharide core region biosynthetic process
ITG12_RS10025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ITG12_RS10030	COG0859	PFAM glycosyl transferase family 9
ITG12_RS10035	COG0463	Glycosyl transferase, family 2
ITG12_RS10040	COG0438	transferase activity, transferring glycosyl groups
ITG12_RS10070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ITG12_RS10080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ITG12_RS10090	COG1560	Kdo2-lipid A biosynthetic process
ITG12_RS10095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ITG12_RS10100	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ITG12_RS10105	COG1561	YicC-like family, N-terminal region
ITG12_RS10110	COG3710	Transcriptional regulator
ITG12_RS10135	COG4608	Belongs to the ABC transporter superfamily
ITG12_RS10140	COG0444	Belongs to the ABC transporter superfamily
ITG12_RS10145	COG0747	negative chemotaxis
ITG12_RS10150	COG4239	(ABC) transporter, permease
ITG12_RS10155	COG4174	ABC transporter (Permease)
ITG12_RS10160	COG4206	TonB-dependent receptor
ITG12_RS10175	COG0811	peptide transport
ITG12_RS10180	COG0848	biopolymer transport protein
ITG12_RS10195	COG0194	GDP metabolic process
ITG12_RS10200	COG1758	RNA polymerase activity
ITG12_RS10205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG12_RS10210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG12_RS10215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ITG12_RS10225	COG2233	PERMEase
ITG12_RS10240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG12_RS10250	COG2183	response to ionizing radiation
ITG12_RS10265	COG1040	competence protein
ITG12_RS10275	COG0494	nUDIX hydrolase
ITG12_RS10280	COG1218	3'(2'),5'-bisphosphate nucleotidase
ITG12_RS10290	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG12_RS10295	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG12_RS10300	COG3156	type II secretion system protein K
ITG12_RS10305	COG4795	General secretion pathway protein
ITG12_RS10310	COG2165	general secretion pathway protein
ITG12_RS10315	COG2165	general secretion pathway protein
ITG12_RS10320	COG2165	general secretion pathway protein
ITG12_RS10325	COG1459	type II secretion system
ITG12_RS10330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG12_RS10340	COG3031	protein transport across the cell outer membrane
ITG12_RS10345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ITG12_RS10365	COG0456	acetyltransferase
ITG12_RS10370	COG1490	D-aminoacyl-tRNA deacylase activity
ITG12_RS10390	COG1217	gtp-binding protein TYPA
ITG12_RS10395	COG0174	glutamine synthetase
ITG12_RS10405	COG3852	Histidine kinase
ITG12_RS10410	COG2204	response regulator
ITG12_RS10415	COG5001	Diguanylate cyclase
ITG12_RS10420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG12_RS10450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ITG12_RS10455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG12_RS10455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG12_RS10470	COG0084	hydrolase, TatD family'
ITG12_RS10475	COG0805	protein transport
ITG12_RS10480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITG12_RS10495	COG3165	ubiquinone biosynthetic process from chorismate
ITG12_RS10505	COG1322	Protein conserved in bacteria
ITG12_RS10530	COG2081	HI0933 family
ITG12_RS10540	COG1528	Iron-storage protein
ITG12_RS10545	COG0589	response to stress
ITG12_RS10565	COG5001	Diguanylate cyclase
ITG12_RS10565	COG5002	protein histidine kinase activity
ITG12_RS10570	COG1522	sequence-specific DNA binding
ITG12_RS10580	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ITG12_RS10590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG12_RS10600	COG0800	Aldolase
ITG12_RS10605	COG2610	gluconate transmembrane transporter activity
ITG12_RS10610	COG3265	gluconokinase activity
ITG12_RS10615	COG0129	dihydroxy-acid dehydratase activity
ITG12_RS10625	COG2076	Multidrug Resistance protein
ITG12_RS10630	COG0583	DNA-binding transcription factor activity
ITG12_RS10635	COG1609	Transcriptional regulator
ITG12_RS10670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG12_RS10675	COG0601	transmembrane transport
ITG12_RS10685	COG4172	Belongs to the ABC transporter superfamily
ITG12_RS10690	COG0546	phosphoglycolate phosphatase activity
ITG12_RS10730	COG1309	transcriptional regulator
ITG12_RS10735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_RS10740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_RS10745	COG2960	long-chain fatty acid transporting porin activity
ITG12_RS10755	COG0583	DNA-binding transcription factor activity
ITG12_RS10805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG12_RS10810	COG1739	Uncharacterized protein family UPF0029
ITG12_RS10820	COG0183	Belongs to the thiolase family
ITG12_RS10825	COG0604	alcohol dehydrogenase
ITG12_RS10840	COG0425	Belongs to the sulfur carrier protein TusA family
ITG12_RS10850	COG2119	membrane
ITG12_RS10860	COG0751	glycine-tRNA ligase activity
ITG12_RS10865	COG0366	Alpha amylase catalytic
ITG12_RS10930	COG4964	Belongs to the GSP D family
ITG12_RS10950	COG3977	Valine--pyruvate aminotransferase
ITG12_RS10955	COG0071	Belongs to the small heat shock protein (HSP20) family
ITG12_RS10960	COG0187	DNA topoisomerase II activity
ITG12_RS10970	COG0592	DNA-directed DNA polymerase activity
ITG12_RS10990	COG1126	abc transporter atp-binding protein
ITG12_RS11020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG12_RS11025	COG0445	tRNA wobble uridine modification
ITG12_RS11030	COG0357	Ribosomal RNA small subunit methyltransferase G
ITG12_RS11035	COG1192	Involved in chromosome partitioning
ITG12_RS11040	COG1475	DNA binding
ITG12_RS11045	COG3312	ion transport
ITG12_RS11075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG12_RS11085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG12_RS11095	COG0765	amino acid transport
ITG12_RS11105	COG2814	Major facilitator Superfamily
ITG12_RS11110	COG0583	DNA-binding transcription factor activity
ITG12_RS11115	COG3706	GGDEF domain
ITG12_RS11130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITG12_RS11135	COG3978	acetolactate synthase activity
ITG12_RS11145	COG0606	chelatase, subunit chli
ITG12_RS11155	COG0204	Acyl-transferase
ITG12_RS11160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG12_RS11165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITG12_RS11175	COG3084	Protein conserved in bacteria
ITG12_RS11185	COG4326	sporulation control protein
ITG12_RS11190	COG1272	protein, Hemolysin III
ITG12_RS11200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG12_RS11205	COG0569	domain protein
ITG12_RS11210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITG12_RS11210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITG12_RS11230	COG0758	DNA mediated transformation
ITG12_RS11240	COG0551	DNA topoisomerase type I activity
ITG12_RS11250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ITG12_RS11255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ITG12_RS11280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ITG12_RS11320	COG2132	Multicopper oxidase
ITG12_RS11340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ITG12_RS11345	COG2104	thiamine diphosphate biosynthetic process
ITG12_RS11360	COG0006	proline dipeptidase activity
ITG12_RS11360	COG0006	proline dipeptidase activity
ITG12_RS11370	COG2814	Major facilitator Superfamily
ITG12_RS11390	COG3220	belongs to the UPF0276 family
ITG12_RS11400	COG0210	DNA helicase
ITG12_RS11405	COG0405	Gamma-glutamyltransferase
ITG12_RS11410	COG1280	lysine exporter protein (LysE YggA)
ITG12_RS11420	COG2962	Rard protein
ITG12_RS11425	COG0514	ATP-dependent DNA helicase (RecQ)
ITG12_RS11435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ITG12_RS11455	COG3118	belongs to the thioredoxin family
ITG12_RS11470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ITG12_RS11475	COG0633	Ferredoxin
ITG12_RS11515	COG3071	HemY protein
ITG12_RS11520	COG2959	enzyme of heme biosynthesis
ITG12_RS11525	COG1587	Uroporphyrinogen-III synthase
ITG12_RS11535	COG3072	Adenylate cyclase
ITG12_RS11550	COG0019	diaminopimelate decarboxylase activity
ITG12_RS11570	COG1011	Hydrolase
ITG12_RS11575	COG2199	diguanylate cyclase activity
ITG12_RS11575	COG3287	FIST C domain
ITG12_RS11575	COG2200	EAL domain
ITG12_RS11580	COG3148	PFAM DTW domain containing protein
ITG12_RS11595	COG0561	phosphatase activity
ITG12_RS11600	COG2267	carboxylic ester hydrolase activity
ITG12_RS11605	COG1280	lysine exporter protein (LysE YggA)
ITG12_RS11610	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG12_RS11615	COG0640	Transcriptional regulator
ITG12_RS11620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG12_RS11665	COG2095	MarC family integral membrane protein
ITG12_RS11675	COG0742	ribosomal rna small subunit methyltransferase
ITG12_RS11680	COG0552	protein localization to endoplasmic reticulum
ITG12_RS11685	COG2884	Cell division ATP-binding protein ftsE
ITG12_RS11690	COG2177	Part of the ABC transporter FtsEX involved in
ITG12_RS11710	COG1580	Controls the rotational direction of flagella during chemotaxis
ITG12_RS11715	COG3161	chorismate lyase activity
ITG12_RS11725	COG2937	Belongs to the GPAT DAPAT family
ITG12_RS11740	COG0534	Mate efflux family protein
ITG12_RS11745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG12_RS11750	COG1309	transcriptional regulator
ITG12_RS11810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG12_RS11820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ITG12_RS11860	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG12_RS11865	COG0250	Participates in transcription elongation, termination and antitermination
ITG12_RS11870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ITG12_RS11875	COG0081	regulation of translation
ITG12_RS11880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ITG12_RS11900	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ITG12_RS11905	COG2816	NAD+ diphosphatase activity
ITG12_RS11915	COG1573	uracil-dna glycosylase
ITG12_RS11925	COG3068	Protein conserved in bacteria
ITG12_RS11930	COG1253	flavin adenine dinucleotide binding
ITG12_RS11945	COG0151	Belongs to the GarS family
ITG12_RS11950	COG0138	bifunctional purine biosynthesis protein purh
ITG12_RS11960	COG0789	Transcriptional regulator
ITG12_RS11965	COG3710	Transcriptional regulator
ITG12_RS11975	COG0531	amino acid
ITG12_RS11980	COG1982	Orn Lys Arg decarboxylase major
ITG12_RS12060	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ITG12_RS12065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG12_RS12075	COG0439	Biotin carboxylase
ITG12_RS12080	COG0511	ligase activity, forming carbon-carbon bonds
ITG12_RS12085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ITG12_RS12090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG12_RS12105	COG2814	Major facilitator Superfamily
ITG12_RS12110	COG2198	Histidine kinase
ITG12_RS12110	COG2205	protein histidine kinase activity
ITG12_RS12110	COG0784	Response regulator, receiver
ITG12_RS12130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG12_RS12140	COG2095	MarC family integral membrane protein
ITG12_RS12150	COG4232	protein-disulfide reductase activity
ITG12_RS12155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG12_RS12160	COG1027	Aspartate ammonia-lyase
ITG12_RS12165	COG3030	protein affecting phage T7 exclusion by the F plasmid
ITG12_RS12170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ITG12_RS12180	COG2205	protein histidine kinase activity
ITG12_RS12185	COG0745	RESPONSE REGULATOR receiver
ITG12_RS12190	COG3678	ATP-independent chaperone mediated protein folding
ITG12_RS12195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ITG12_RS12205	COG0534	Mate efflux family protein
ITG12_RS12215	COG0459	protein refolding
ITG12_RS12225	COG1285	pathogenesis
ITG12_RS12230	COG1509	lysine 2,3-aminomutase activity
ITG12_RS12255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITG12_RS12260	COG1053	succinate dehydrogenase
ITG12_RS12285	COG4942	peptidase
ITG12_RS12290	COG1045	serine acetyltransferase
ITG12_RS12305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG12_RS12310	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ITG12_RS12320	COG0840	transmembrane signaling receptor activity
ITG12_RS12325	COG0471	metal ion transport
ITG12_RS12335	COG1162	GTPase activity
ITG12_RS12415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ITG12_RS12420	COG0802	atpase or kinase
ITG12_RS12425	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITG12_RS12430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ITG12_RS12445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITG12_RS12450	COG0330	HflC and HflK could
ITG12_RS12455	COG0330	HflC and HflK could
ITG12_RS12460	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ITG12_RS12465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG12_RS12470	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ITG12_RS12475	COG1017	nitric oxide dioxygenase activity
ITG12_RS12475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG12_RS12485	COG0557	exoribonuclease II activity
ITG12_RS12490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG12_RS12495	COG0546	phosphoglycolate phosphatase activity
ITG12_RS12520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ITG12_RS12540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG12_RS12545	COG3954	Phosphoribulokinase
ITG12_RS12555	COG0429	hydrolase of the alpha beta-hydrolase fold
ITG12_RS12565	COG0488	(ABC) transporter
ITG12_RS12570	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG12_RS12585	COG1047	Peptidyl-prolyl cis-trans
ITG12_RS12590	COG1446	asparaginase
ITG12_RS12605	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG12_RS12610	COG2964	Protein conserved in bacteria
ITG12_RS12615	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ITG12_RS12620	COG2923	Belongs to the DsrF TusC family
ITG12_RS12625	COG2168	tRNA wobble position uridine thiolation
ITG12_RS12640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG12_RS12650	COG2906	2 iron, 2 sulfur cluster binding
ITG12_RS12660	COG0281	malic enzyme
ITG12_RS12670	COG0626	cystathionine gamma-synthase activity
ITG12_RS12675	COG0460	homoserine dehydrogenase
ITG12_RS12675	COG0527	aspartate kinase activity
ITG12_RS12680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITG12_RS12690	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ITG12_RS12700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ITG12_RS12715	COG0165	Argininosuccinate lyase
ITG12_RS12715	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG12_RS12725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG12_RS12730	COG0678	peroxiredoxin activity
ITG12_RS12730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG12_RS12740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ITG12_RS12785	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ITG12_RS12790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ITG12_RS12800	COG2965	DNA replication, synthesis of RNA primer
ITG12_RS12825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ITG12_RS12835	COG0432	Pfam Uncharacterised protein family UPF0047
ITG12_RS12850	COG0735	belongs to the Fur family
ITG12_RS12855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG12_RS12875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG12_RS12950	COG0646	methionine synthase
ITG12_RS12950	COG1410	methionine synthase
ITG12_RS12955	COG0527	aspartate kinase activity
ITG12_RS12960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ITG12_RS12970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ITG12_RS12985	COG0629	single-stranded DNA binding
ITG12_RS12995	COG2199	diguanylate cyclase activity
ITG12_RS12995	COG2200	EAL domain
ITG12_RS13020	COG3409	Peptidoglycan-binding domain 1 protein
ITG12_RS13020	COG3267	Type II secretory pathway component ExeA
ITG12_RS13030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG12_RS13035	COG1459	type II secretion system
ITG12_RS13045	COG2165	general secretion pathway protein
ITG12_RS13080	COG1077	Cell shape determining protein MreB Mrl
ITG12_RS13085	COG1792	Involved in formation and maintenance of cell shape
ITG12_RS13090	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ITG12_RS13095	COG0424	maF-like protein
ITG12_RS13105	COG3164	Protein of unknown function
ITG12_RS13110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ITG12_RS13115	COG0312	modulator of DNA gyrase
ITG12_RS13120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ITG12_RS13135	COG0564	pseudouridine synthase activity
ITG12_RS13140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG12_RS13145	COG3028	Belongs to the UPF0307 family
ITG12_RS13150	COG0312	modulator of DNA gyrase
ITG12_RS13155	COG2239	Acts as a magnesium transporter
ITG12_RS13160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_RS13170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_RS13175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG12_RS13185	COG1137	ATPase activity
ITG12_RS13190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ITG12_RS13200	COG0517	IMP dehydrogenase activity
ITG12_RS13200	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ITG12_RS13210	COG1127	ABC transporter
ITG12_RS13215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ITG12_RS13220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG12_RS13225	COG2854	intermembrane phospholipid transfer
ITG12_RS13235	COG5007	Belongs to the BolA IbaG family
ITG12_RS13245	COG0204	Acyl-transferase
ITG12_RS13250	COG0251	oxidation-reduction process
ITG12_RS13290	COG0456	acetyltransferase
ITG12_RS13300	COG0525	valine-tRNA ligase activity
ITG12_RS13305	COG2927	DNA polymerase III (CHI subunit)
ITG12_RS13315	COG0795	lipopolysaccharide-transporting ATPase activity
ITG12_RS13320	COG0795	lipopolysaccharide-transporting ATPase activity
ITG12_RS13330	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS13340	COG0726	polysaccharide deacetylase
ITG12_RS13345	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITG12_RS13355	COG1447	Phosphotransferase system cellobiose-specific component IIA
ITG12_RS13360	COG1486	melibiose metabolic process
ITG12_RS13365	COG3394	polysaccharide catabolic process
ITG12_RS13425	COG1012	belongs to the aldehyde dehydrogenase family
ITG12_RS13525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ITG12_RS13530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ITG12_RS13540	COG1872	DUF167
ITG12_RS13545	COG0762	integral membrane protein
ITG12_RS13550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ITG12_RS13555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ITG12_RS13570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ITG12_RS13575	COG1678	Uncharacterized ACR, COG1678
ITG12_RS13580	COG0189	ligase activity
ITG12_RS13585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ITG12_RS13590	COG2356	endonuclease I
ITG12_RS13610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG12_RS13630	COG0191	fructose-bisphosphate aldolase activity
ITG12_RS13635	COG0668	transmembrane transport
ITG12_RS13650	COG0583	DNA-binding transcription factor activity
ITG12_RS13660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG12_RS13670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ITG12_RS13680	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ITG12_RS13685	COG3079	Belongs to the UPF0149 family
ITG12_RS13690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG12_RS13695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG12_RS13715	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ITG12_RS13725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ITG12_RS13730	COG1595	DNA-templated transcription, initiation
ITG12_RS13740	COG3026	antisigma factor binding
ITG12_RS13750	COG0481	GTPase activity
ITG12_RS13765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ITG12_RS13770	COG1381	Involved in DNA repair and RecF pathway recombination
ITG12_RS13775	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ITG12_RS13795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG12_RS13800	COG3956	TIGRFAM MazG family protein
ITG12_RS13810	COG0148	phosphopyruvate hydratase activity
ITG12_RS13820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ITG12_RS13850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ITG12_RS13860	COG1546	Belongs to the CinA family
ITG12_RS13865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ITG12_RS13970	COG3630	sodium ion export across plasma membrane
ITG12_RS13975	COG5016	pyruvate
ITG12_RS13975	COG0511	ligase activity, forming carbon-carbon bonds
ITG12_RS13980	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ITG12_RS13990	COG1238	metal cluster binding
ITG12_RS13995	COG0612	Peptidase, M16
ITG12_RS14015	COG4536	flavin adenine dinucleotide binding
ITG12_RS14020	COG4137	Cytochrome C assembly protein
ITG12_RS14025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ITG12_RS14030	COG0228	four-way junction DNA binding
ITG12_RS14050	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ITG12_RS14055	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ITG12_RS14060	COG0237	dephospho-CoA kinase activity
ITG12_RS14070	COG1459	type II secretion system
ITG12_RS14075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG12_RS14095	COG2186	Transcriptional regulator
ITG12_RS14100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ITG12_RS14105	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG12_RS14110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG12_RS14125	COG0288	reversible hydration of carbon dioxide
ITG12_RS14130	COG0659	secondary active sulfate transmembrane transporter activity
ITG12_RS14135	COG1131	(ABC) transporter
ITG12_RS14140	COG0842	Transport permease protein
ITG12_RS14145	COG1560	Kdo2-lipid A biosynthetic process
ITG12_RS14160	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG12_RS14170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ITG12_RS14185	COG1643	Atp-dependent helicase
ITG12_RS14190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITG12_RS14195	COG1752	Esterase of the alpha-beta hydrolase superfamily
ITG12_RS14200	COG1049	propionate catabolic process, 2-methylcitrate cycle
ITG12_RS14215	COG0004	ammonium transporteR
ITG12_RS14220	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG12_RS14230	COG3842	ATPase activity
ITG12_RS14235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG12_RS14250	COG2971	BadF BadG BcrA BcrD
ITG12_RS14260	COG4608	Belongs to the ABC transporter superfamily
ITG12_RS14265	COG0444	Belongs to the ABC transporter superfamily
ITG12_RS14270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG12_RS14280	COG0747	negative chemotaxis
ITG12_RS14285	COG0784	Response regulator, receiver
ITG12_RS14285	COG2205	protein histidine kinase activity
ITG12_RS14295	COG0628	permease
ITG12_RS14315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_RS14320	COG0739	heme binding
ITG12_RS14325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ITG12_RS14335	COG2027	D-alanyl-D-alanine carboxypeptidase
ITG12_RS14340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG12_RS14345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG12_RS14350	COG1534	Rna-binding protein
ITG12_RS14355	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ITG12_RS14360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ITG12_RS14365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ITG12_RS14375	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG12_RS14395	COG0195	Participates in both transcription termination and antitermination
ITG12_RS14415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ITG12_RS14435	COG0534	Mate efflux family protein
ITG12_RS14440	COG0826	peptidase U32
ITG12_RS14445	COG0826	peptidase U32
ITG12_RS14455	COG3154	lipid carrier protein
ITG12_RS14460	COG3153	acetyltransferase
ITG12_RS14490	COG0084	hydrolase, TatD family'
ITG12_RS14495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG12_RS14500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ITG12_RS14505	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ITG12_RS14515	COG0813	purine-nucleoside phosphorylase activity
ITG12_RS14525	COG0560	Phosphoserine phosphatase
ITG12_RS14535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ITG12_RS14540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG12_RS14545	COG0583	DNA-binding transcription factor activity
ITG12_RS14580	COG1022	Amp-dependent synthetase and ligase
ITG12_RS14585	COG0741	lytic transglycosylase activity
ITG12_RS14610	COG4964	Belongs to the GSP D family
ITG12_RS14670	COG0583	DNA-binding transcription factor activity
ITG12_RS14675	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ITG12_RS14675	COG3408	Glycogen debranching enzyme
ITG12_RS14685	COG0531	amino acid
ITG12_RS14690	COG2731	YhcH YjgK YiaL family protein
ITG12_RS14695	COG3250	beta-galactosidase activity
ITG12_RS14700	COG1609	Transcriptional regulator
ITG12_RS14705	COG0768	penicillin binding
ITG12_RS14710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ITG12_RS14715	COG1085	galactose-1-phosphate uridylyltransferase
ITG12_RS14725	COG2017	converts alpha-aldose to the beta-anomer
ITG12_RS14730	COG1609	Transcriptional regulator
ITG12_RS14735	COG1263	PTS System
ITG12_RS14735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_RS14745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG12_RS14770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ITG12_RS14775	COG1349	DNA-binding transcription factor activity
ITG12_RS14785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ITG12_RS14790	COG2271	Major facilitator Superfamily
ITG12_RS14795	COG0584	glycerophosphoryl diester phosphodiesterase
ITG12_RS14810	COG2171	N-acyltransferase activity
ITG12_RS14825	COG3141	response to X-ray
ITG12_RS14840	COG2261	transglycosylase associated protein
ITG12_RS14850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ITG12_RS14855	COG1074	ATP-dependent DNA helicase activity
ITG12_RS14860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ITG12_RS14880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ITG12_RS14880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG12_RS14890	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ITG12_RS14895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ITG12_RS14900	COG2166	iron-sulfur cluster assembly
ITG12_RS14905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITG12_RS14910	COG0693	protein deglycase activity
ITG12_RS14915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ITG12_RS14920	COG3248	Nucleoside-binding outer membrane protein
ITG12_RS14935	COG1595	DNA-templated transcription, initiation
ITG12_RS14965	COG0271	Belongs to the BolA IbaG family
ITG12_RS14970	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG12_RS14990	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG12_RS15000	COG1477	protein flavinylation
ITG12_RS15015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITG12_RS15020	COG0514	ATP-dependent DNA helicase (RecQ)
ITG12_RS15025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG12_RS15040	COG0733	neurotransmitter:sodium symporter activity
ITG12_RS15065	COG1720	tRNA m6t6A37 methyltransferase activity
ITG12_RS15080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG12_RS15115	COG3098	single-species biofilm formation
ITG12_RS15120	COG0564	pseudouridine synthase activity
ITG12_RS15135	COG0024	Methionine aminopeptidase
ITG12_RS15160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ITG12_RS15165	COG0575	Belongs to the CDS family
ITG12_RS15175	COG0750	zinc metalloprotease
ITG12_RS15185	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ITG12_RS15190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG12_RS15215	COG0587	DNA-directed DNA polymerase activity
ITG12_RS15235	COG0347	Belongs to the P(II) protein family
ITG12_RS15250	COG1388	LysM domain
ITG12_RS15250	COG0741	lytic transglycosylase activity
ITG12_RS15260	COG2226	methyltransferase
ITG12_RS15270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ITG12_RS15305	COG1960	acyl-CoA dehydrogenase activity
ITG12_RS15310	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG12_RS15315	COG0121	glutamine amidotransferase
ITG12_RS15320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ITG12_RS15325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ITG12_RS15330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ITG12_RS15335	COG2233	PERMEase
ITG12_RS15355	COG1393	Belongs to the ArsC family
ITG12_RS15360	COG4783	chaperone-mediated protein folding
ITG12_RS15375	COG3385	transposase activity
ITG12_RS15430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ITG12_RS15460	COG2716	regulation of RNA biosynthetic process
ITG12_RS15465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ITG12_RS15470	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ITG12_RS15485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG12_RS15490	COG1393	Belongs to the ArsC family
ITG12_RS15515	COG2837	iron assimilation
ITG12_RS15520	COG2169	Transcriptional regulator
ITG12_RS15525	COG1486	melibiose metabolic process
ITG12_RS15530	COG2211	Major facilitator Superfamily
ITG12_RS15540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_RS15545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_RS15550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_RS15555	COG1334	flagellar protein FlaG
ITG12_RS15560	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ITG12_RS15570	COG1516	flagellar protein fliS
ITG12_RS15590	COG1677	Flagellar hook-basal body complex protein FliE
ITG12_RS15600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ITG12_RS15655	COG1987	bacterial-type flagellum assembly
ITG12_RS15660	COG1684	flagellar biosynthetic protein fliR
ITG12_RS15695	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ITG12_RS15700	COG2198	Histidine kinase
ITG12_RS15700	COG0784	Response regulator, receiver
ITG12_RS15700	COG0643	Histidine kinase
ITG12_RS15705	COG2201	protein-glutamate methylesterase activity
ITG12_RS15710	COG1192	Involved in chromosome partitioning
ITG12_RS15720	COG0835	chemotaxis
ITG12_RS15730	COG4133	protoheme IX ABC transporter activity
ITG12_RS15735	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG12_RS15740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG12_RS15755	COG1138	Cytochrome C-type biogenesis protein
ITG12_RS15760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITG12_RS15770	COG4235	cytochrome complex assembly
ITG12_RS15770	COG3088	subunit of a heme lyase
ITG12_RS15775	COG2853	Lipoprotein
ITG12_RS15780	COG2067	long-chain fatty acid transport protein
ITG12_RS15785	COG2067	long-chain fatty acid transport protein
ITG12_RS15800	COG0183	Belongs to the thiolase family
ITG12_RS15820	COG2062	phosphohistidine phosphatase, SixA
ITG12_RS15830	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG12_RS15840	COG2860	membrane
ITG12_RS15845	COG3101	peptidyl-lysine hydroxylation
ITG12_RS15865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ITG12_RS15870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG12_RS15875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG12_RS15895	COG0285	dihydrofolate synthase activity
ITG12_RS15900	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ITG12_RS15905	COG1286	toxin biosynthetic process
ITG12_RS15910	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ITG12_RS15915	COG0583	DNA-binding transcription factor activity
ITG12_RS15920	COG0745	RESPONSE REGULATOR receiver
ITG12_RS15925	COG2832	Protein of unknown function (DUF454)
ITG12_RS15945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ITG12_RS15950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ITG12_RS15955	COG0814	amino acid
ITG12_RS15960	COG0251	oxidation-reduction process
ITG12_RS15970	COG2964	Protein conserved in bacteria
ITG12_RS15985	COG2983	Belongs to the UPF0260 family
ITG12_RS15990	COG2261	transglycosylase associated protein
ITG12_RS15995	COG2985	domain, Protein
ITG12_RS16000	COG0076	glutamate decarboxylase activity
ITG12_RS16005	COG0668	transmembrane transport
ITG12_RS16015	COG0346	lactoylglutathione lyase activity
ITG12_RS16025	COG1785	Belongs to the alkaline phosphatase family
ITG12_RS16045	COG2226	methyltransferase
ITG12_RS16070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG12_RS16075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_RS16085	COG3139	Protein of unknown function (DUF1315)
ITG12_RS16090	COG0252	asparaginase activity
ITG12_RS16095	COG0616	signal peptide processing
ITG12_RS16100	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG12_RS16100	COG1902	pentaerythritol trinitrate reductase activity
ITG12_RS16105	COG0778	Nitroreductase
ITG12_RS16110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG12_RS16125	COG0123	including yeast histone deacetylase and acetoin utilization protein
ITG12_RS16130	COG4269	membrane
ITG12_RS16145	COG3083	sulfuric ester hydrolase activity
ITG12_RS16170	COG1757	Na H antiporter
ITG12_RS16175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG12_RS16180	COG2165	general secretion pathway protein
ITG12_RS16185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG12_RS16190	COG2095	MarC family integral membrane protein
ITG12_RS16195	COG1454	alcohol dehydrogenase
ITG12_RS16195	COG1012	belongs to the aldehyde dehydrogenase family
ITG12_RS16215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ITG12_RS16225	COG2056	Na+-H+ antiporter family
ITG12_RS16235	COG2885	chlorophyll binding
ITG12_RS16245	COG0346	lactoylglutathione lyase activity
ITG12_RS16250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ITG12_RS16255	COG4660	Part of a membrane complex involved in electron transport
ITG12_RS16260	COG4659	FMN binding
ITG12_RS16265	COG4658	electron transport chain
ITG12_RS16270	COG4656	Part of a membrane complex involved in electron transport
ITG12_RS16280	COG4657	Part of a membrane complex involved in electron transport
ITG12_RS16285	COG1882	Formate acetyltransferase
ITG12_RS16295	COG0556	nucleotide-excision repair
ITG12_RS16305	COG2198	Histidine kinase
ITG12_RS16310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ITG12_RS16315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ITG12_RS16320	COG0521	Mo-molybdopterin cofactor biosynthetic process
ITG12_RS16325	COG0315	cyclic pyranopterin monophosphate synthase activity
ITG12_RS16330	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ITG12_RS16335	COG0314	molybdopterin synthase activity
ITG12_RS16345	COG0601	transmembrane transport
ITG12_RS16350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG12_RS16355	COG0444	Belongs to the ABC transporter superfamily
ITG12_RS16365	COG0435	Glutathione S-transferase
ITG12_RS16375	COG3174	membrane
ITG12_RS16380	COG0857	belongs to the CobB CobQ family
ITG12_RS16380	COG0280	phosphate acetyltransferase
ITG12_RS16400	COG4120	Belongs to the binding-protein-dependent transport system permease family
ITG12_RS16405	COG1122	ATPase activity
ITG12_RS16410	COG0366	Alpha amylase catalytic
ITG12_RS16415	COG3706	GGDEF domain
ITG12_RS16420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG12_RS16425	COG3012	SEC-C Motif Domain Protein
ITG12_RS16425	COG3318	Belongs to the UPF0149 family
ITG12_RS16430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITG12_RS16440	COG2186	Transcriptional regulator
ITG12_RS16450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG12_RS16450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG12_RS16465	COG2982	Protein involved in outer membrane biogenesis
ITG12_RS16470	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ITG12_RS16475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ITG12_RS16480	COG0659	secondary active sulfate transmembrane transporter activity
ITG12_RS16485	COG1530	ribonuclease E activity
ITG12_RS16490	COG0564	pseudouridine synthase activity
ITG12_RS16495	COG0424	maF-like protein
ITG12_RS16500	COG1399	metal-binding, possibly nucleic acid-binding protein
ITG12_RS16515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG12_RS16545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ITG12_RS16560	COG0084	hydrolase, TatD family'
ITG12_RS16565	COG1263	PTS System
ITG12_RS16565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_RS16580	COG0733	neurotransmitter:sodium symporter activity
ITG12_RS16595	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG12_RS16605	COG1940	carbohydrate kinase activity
ITG12_RS16610	COG0784	Response regulator, receiver
ITG12_RS16610	COG0835	chemotaxis
ITG12_RS16630	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS16635	COG0616	signal peptide processing
ITG12_RS16650	COG0539	negative regulation of cytoplasmic translation
ITG12_RS16660	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ITG12_RS16665	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ITG12_RS16675	COG4166	transmembrane transport
ITG12_RS16705	COG3119	arylsulfatase activity
ITG12_RS16710	COG1309	transcriptional regulator
ITG12_RS16715	COG3009	Protein conserved in bacteria
ITG12_RS16720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG12_RS16720	COG3008	intermembrane lipid transfer
ITG12_RS16725	COG2995	paraquat-inducible protein a
ITG12_RS16730	COG1609	Transcriptional regulator
ITG12_RS16735	COG3258	Cytochrome c
ITG12_RS16740	COG2863	cytochrome
ITG12_RS16770	COG3250	beta-galactosidase activity
ITG12_RS16780	COG4580	involved in the transport of maltose and maltodextrins
ITG12_RS16790	COG2211	Major facilitator Superfamily
ITG12_RS16795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG12_RS16810	COG4232	protein-disulfide reductase activity
ITG12_RS16815	COG3118	belongs to the thioredoxin family
ITG12_RS16840	COG3153	acetyltransferase
ITG12_RS16855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_RS16875	COG0577	efflux transmembrane transporter activity
ITG12_RS16875	COG1136	(ABC) transporter
ITG12_RS16890	COG2176	DNA-directed DNA polymerase activity
ITG12_RS16915	COG2801	Transposase and inactivated derivatives
ITG12_RS16920	COG0840	transmembrane signaling receptor activity
ITG12_RS16930	COG0573	inorganic phosphate transmembrane transporter activity
ITG12_RS16935	COG0581	inorganic phosphate transmembrane transporter activity
ITG12_RS16940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG12_RS16955	COG2304	oxidoreductase activity
ITG12_RS16975	COG0714	Associated with various cellular activities
ITG12_RS16995	COG0840	transmembrane signaling receptor activity
ITG12_RS17005	COG2197	response regulator
ITG12_RS17030	COG0110	maltose O-acetyltransferase activity
ITG12_RS17040	COG4191	Histidine kinase
ITG12_RS17050	COG0573	inorganic phosphate transmembrane transporter activity
ITG12_RS17060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG12_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS17110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITG12_RS17115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITG12_RS17120	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
ITG12_RS17175	COG1252	NADH dehydrogenase
ITG12_RS17180	COG1301	dicarboxylic acid transport
ITG12_RS17190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG12_RS17220	COG1566	PFAM secretion protein HlyD family protein
ITG12_RS17225	COG0583	DNA-binding transcription factor activity
ITG12_RS17250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_RS17250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_RS17250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_RS17255	COG2207	Transcriptional regulator
ITG12_RS17265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_RS17270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_RS17275	COG0583	DNA-binding transcription factor activity
ITG12_RS17285	COG2084	Dehydrogenase
ITG12_RS17290	COG0753	catalase activity
ITG12_RS17300	COG2130	NADP-dependent
ITG12_RS17305	COG1309	transcriptional regulator
ITG12_RS17355	COG3206	protein involved in exopolysaccharide biosynthesis
ITG12_RS17355	COG0489	protein tyrosine kinase activity
ITG12_RS17370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG12_RS17375	COG3842	ATPase activity
ITG12_RS17385	COG1175	transmembrane transport
ITG12_RS17390	COG3833	ABC-type maltose transport systems, permease component
ITG12_RS17420	COG2354	Protein conserved in bacteria
ITG12_RS17430	COG0401	homolog of Blt101
ITG12_RS17435	COG0633	Ferredoxin
ITG12_RS17435	COG3217	Mosc domain protein beta barrel domain protein
ITG12_RS17435	COG0633	Ferredoxin
ITG12_RS17435	COG3217	Mosc domain protein beta barrel domain protein
ITG12_RS17445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ITG12_RS17485	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ITG12_RS17490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG12_RS17500	COG0848	biopolymer transport protein
ITG12_RS17505	COG0811	peptide transport
ITG12_RS17510	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ITG12_RS17520	COG3721	Heme iron utilization protein
ITG12_RS17525	COG0748	coenzyme F420 binding
ITG12_RS17540	COG0835	chemotaxis
ITG12_RS17540	COG0784	Response regulator, receiver
ITG12_RS17545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG12_RS17550	COG0366	Alpha amylase catalytic
ITG12_RS17555	COG0604	alcohol dehydrogenase
ITG12_RS17555	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS17555	COG3321	synthase
ITG12_RS17595	COG0583	DNA-binding transcription factor activity
ITG12_RS17610	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG12_RS17615	COG0583	DNA-binding transcription factor activity
ITG12_RS17650	COG1335	isochorismatase
ITG12_RS17665	COG2194	sulfuric ester hydrolase activity
ITG12_RS17670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ITG12_RS17680	COG2205	protein histidine kinase activity
ITG12_RS17685	COG0745	RESPONSE REGULATOR receiver
ITG12_RS17700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_RS17705	COG4948	Mandelate Racemase Muconate Lactonizing
ITG12_RS17710	COG1053	succinate dehydrogenase
ITG12_RS17710	COG3976	FMN-binding domain protein
ITG12_RS17720	COG4221	oxidoreductase activity
ITG12_RS17735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG12_RS17755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG12_RS17765	COG2814	Major facilitator Superfamily
ITG12_RS17780	COG1418	mRNA catabolic process
ITG12_RS17795	COG0402	S-adenosylhomocysteine deaminase activity
ITG12_RS17800	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ITG12_RS17805	COG2239	Acts as a magnesium transporter
ITG12_RS17810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ITG12_RS17815	COG1566	PFAM secretion protein HlyD family protein
ITG12_RS17840	COG0745	RESPONSE REGULATOR receiver
ITG12_RS17845	COG2205	protein histidine kinase activity
ITG12_RS17860	COG0531	amino acid
ITG12_RS17865	COG1522	sequence-specific DNA binding
ITG12_RS17875	COG0583	DNA-binding transcription factor activity
ITG12_RS17895	COG0784	Response regulator, receiver
ITG12_RS17895	COG2205	protein histidine kinase activity
ITG12_RS17895	COG5002	protein histidine kinase activity
ITG12_RS17900	COG0673	inositol 2-dehydrogenase activity
ITG12_RS17905	COG0534	Mate efflux family protein
ITG12_RS17975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG12_RS17980	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG12_RS17990	COG1280	lysine exporter protein (LysE YggA)
ITG12_RS18000	COG0183	Belongs to the thiolase family
ITG12_RS18020	COG3005	denitrification pathway
ITG12_RS18040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG12_RS18045	COG3850	Histidine kinase
ITG12_RS18050	COG2197	response regulator
ITG12_RS18065	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG12_RS18090	COG0840	transmembrane signaling receptor activity
ITG12_RS18100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG12_RS18105	COG2197	response regulator
ITG12_RS18130	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG12_RS18160	COG1278	Cold shock
ITG12_RS18165	COG3036	rescue of stalled ribosome
ITG12_RS18175	COG2199	diguanylate cyclase activity
ITG12_RS18195	COG0577	efflux transmembrane transporter activity
ITG12_RS18195	COG1136	(ABC) transporter
ITG12_RS18220	COG1132	(ABC) transporter
ITG12_RS18225	COG1538	Outer membrane efflux protein
ITG12_RS18230	COG0784	Response regulator, receiver
ITG12_RS18230	COG2205	protein histidine kinase activity
ITG12_RS18255	COG0840	transmembrane signaling receptor activity
ITG12_RS18265	COG0783	Belongs to the Dps family
ITG12_RS18275	COG1619	proteins homologs of microcin C7 resistance protein MccF
ITG12_RS18280	COG2133	pyrroloquinoline quinone binding
ITG12_RS18285	COG1454	alcohol dehydrogenase
ITG12_RS18290	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ITG12_RS18315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG12_RS18320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG12_RS18325	COG3186	Phenylalanine-4-hydroxylase
ITG12_RS18355	COG3530	Putative quorum-sensing-regulated virulence factor
ITG12_RS18390	COG0523	cobalamin synthesis protein
ITG12_RS18410	COG0513	Belongs to the DEAD box helicase family
ITG12_RS18430	COG3300	MHYT domain
ITG12_RS18430	COG5001	Diguanylate cyclase
ITG12_RS18435	COG1119	ATPase activity
ITG12_RS18450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ITG12_RS18465	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ITG12_RS18470	COG0513	Belongs to the DEAD box helicase family
ITG12_RS18475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITG12_RS18490	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG12_RS18520	COG1024	Enoyl-CoA hydratase
ITG12_RS18525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ITG12_RS18530	COG1960	acyl-CoA dehydrogenase activity
ITG12_RS18540	COG0183	Belongs to the thiolase family
ITG12_RS18555	COG1024	Enoyl-CoA hydratase
ITG12_RS18560	COG1024	Enoyl-CoA hydratase
ITG12_RS18570	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS18580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ITG12_RS18585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITG12_RS18590	COG1845	cytochrome c oxidase, subunit III
ITG12_RS18595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ITG12_RS18615	COG1902	pentaerythritol trinitrate reductase activity
ITG12_RS18615	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG12_RS18640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_RS18680	COG1126	abc transporter atp-binding protein
ITG12_RS18685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG12_RS18690	COG4215	(ABC) transporter
ITG12_RS18695	COG4160	amino acid transport
ITG12_RS18725	COG3119	arylsulfatase activity
ITG12_RS18770	COG0443	Heat shock 70 kDa protein
ITG12_RS18775	COG2847	Copper chaperone PCu(A)C
ITG12_RS18805	COG0745	RESPONSE REGULATOR receiver
ITG12_RS18820	COG1785	Belongs to the alkaline phosphatase family
ITG12_RS18845	COG0814	amino acid
ITG12_RS18850	COG5002	protein histidine kinase activity
ITG12_RS18850	COG5001	Diguanylate cyclase
ITG12_RS18860	COG0243	molybdopterin cofactor binding
ITG12_RS18880	COG3707	response regulator
ITG12_RS18885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ITG12_RS18885	COG1116	anion transmembrane transporter activity
ITG12_RS18890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ITG12_RS18895	COG1116	anion transmembrane transporter activity
ITG12_RS18900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG12_RS18900	COG2146	nitrite reductase [NAD(P)H] activity
ITG12_RS18935	COG2165	general secretion pathway protein
ITG12_RS18945	COG2165	general secretion pathway protein
ITG12_RS18950	COG0745	RESPONSE REGULATOR receiver
ITG12_RS18955	COG2205	protein histidine kinase activity
ITG12_RS18955	COG2770	Histidine kinase
ITG12_RS18970	COG1294	oxidase, subunit
ITG12_RS18975	COG1271	oxidase subunit
ITG12_RS18985	COG0583	DNA-binding transcription factor activity
ITG12_RS18995	COG0739	heme binding
ITG12_RS19030	COG0628	permease
ITG12_RS19060	COG0604	alcohol dehydrogenase
ITG12_RS19060	COG3321	synthase
ITG12_RS19065	COG1024	Enoyl-CoA hydratase
ITG12_RS19080	COG0523	cobalamin synthesis protein
ITG12_RS19100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_RS19115	COG2207	Transcriptional regulator
ITG12_RS19115	COG0662	Cupin 2, conserved barrel domain protein
ITG12_RS19210	COG1132	(ABC) transporter
ITG12_RS19245	COG1733	regulation of RNA biosynthetic process
ITG12_RS19280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ITG12_RS19290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ITG12_RS19300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_RS19305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_RS19335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_RS19335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_RS19335	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ITG12_RS19340	COG1105	Belongs to the carbohydrate kinase PfkB family
ITG12_RS19345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_RS19345	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_RS19350	COG1609	Transcriptional regulator
ITG12_RS19365	COG2199	diguanylate cyclase activity
ITG12_RS19365	COG2200	EAL domain
ITG12_RS19365	COG2203	Gaf domain
ITG12_RS19370	COG0765	amino acid transport
ITG12_RS19375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG12_RS19380	COG0765	amino acid transport
ITG12_RS19385	COG1126	abc transporter atp-binding protein
ITG12_RS19395	COG1979	alcohol dehydrogenase
ITG12_RS19400	COG2207	Transcriptional regulator
ITG12_RS19410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG12_RS19420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_RS19435	COG0784	Response regulator, receiver
ITG12_RS19435	COG3437	response regulator, receiver
ITG12_RS19440	COG0546	phosphoglycolate phosphatase activity
ITG12_RS19445	COG0840	transmembrane signaling receptor activity
ITG12_RS19450	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ITG12_RS19455	COG0513	Belongs to the DEAD box helicase family
ITG12_RS19460	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ITG12_RS19475	COG3038	cytochrome b561
ITG12_RS19485	COG2116	formate transmembrane transporter activity
ITG12_RS19490	COG0583	DNA-binding transcription factor activity
ITG12_RS19500	COG3593	DNA synthesis involved in DNA repair
ITG12_RS19505	COG0737	Belongs to the 5'-nucleotidase family
ITG12_RS19510	COG0861	Integral membrane protein TerC family
ITG12_RS19525	COG0646	methionine synthase
ITG12_RS19525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITG12_RS19540	COG2267	carboxylic ester hydrolase activity
ITG12_RS19545	COG2067	long-chain fatty acid transport protein
ITG12_RS19560	COG2050	protein possibly involved in aromatic compounds catabolism
ITG12_RS19595	COG0484	heat shock protein binding
ITG12_RS19605	COG1716	ATPase activity
ITG12_RS19605	COG5001	Diguanylate cyclase
ITG12_RS19610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG12_RS19620	COG4181	ATPase activity
ITG12_RS19625	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ITG12_RS19635	COG1984	allophanate hydrolase subunit 2
ITG12_RS19640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ITG12_RS19650	COG3447	MASE1 domain protein
ITG12_RS19650	COG5001	Diguanylate cyclase
ITG12_RS19650	COG5002	protein histidine kinase activity
ITG12_RS19655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ITG12_RS19665	COG0583	DNA-binding transcription factor activity
ITG12_RS19670	COG1042	CoA-binding domain protein
ITG12_RS19670	COG0045	succinate-CoA ligase (ADP-forming) activity
ITG12_RS19670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG12_RS19690	COG0023	Translation Initiation Factor
ITG12_RS19740	COG4128	Pfam Zonular occludens toxin
ITG12_RS19770	COG2801	Transposase and inactivated derivatives
ITG12_RS19790	COG3140	Belongs to the UPF0181 family
ITG12_RS19805	COG0745	RESPONSE REGULATOR receiver
ITG12_RS19815	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ITG12_RS19820	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ITG12_RS19850	COG5001	Diguanylate cyclase
ITG12_RS19850	COG2203	Gaf domain
ITG12_RS19850	COG3706	GGDEF domain
ITG12_RS19850	COG4251	negative regulation of phosphorylation
ITG12_RS19860	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ITG12_RS19865	COG4149	molybdate abc transporter
ITG12_RS19870	COG0725	ABC transporter, periplasmic molybdate-binding protein
ITG12_RS19880	COG3111	PFAM Bacterial OB fold (BOF) protein
ITG12_RS19900	COG2207	Transcriptional regulator
ITG12_RS19905	COG0534	Mate efflux family protein
ITG12_RS19910	COG0602	queuosine metabolic process
ITG12_RS19915	COG1328	CTP reductase activity
ITG12_RS19975	COG2197	response regulator
ITG12_RS19980	COG3851	Histidine kinase
ITG12_RS19985	COG2271	Major facilitator Superfamily
ITG12_RS19990	COG1482	cell wall glycoprotein biosynthetic process
ITG12_RS20000	COG0628	permease
ITG12_RS20010	COG1566	PFAM secretion protein HlyD family protein
ITG12_RS20040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG12_RS20045	COG3118	belongs to the thioredoxin family
ITG12_RS20055	COG0745	RESPONSE REGULATOR receiver
ITG12_RS20055	COG2205	protein histidine kinase activity
ITG12_RS20055	COG3292	Two component regulator propeller
ITG12_RS20060	COG0534	Mate efflux family protein
ITG12_RS20080	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG12_RS20100	COG2116	formate transmembrane transporter activity
ITG12_RS20110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG12_RS20120	COG2199	diguanylate cyclase activity
ITG12_RS20170	COG0277	FAD linked oxidase domain protein
ITG12_RS20175	COG0583	DNA-binding transcription factor activity
ITG12_RS20180	COG1472	Belongs to the glycosyl hydrolase 3 family
ITG12_RS20190	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ITG12_RS20205	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ITG12_RS20215	COG1288	antiporter activity
ITG12_RS20225	COG3040	lipid binding
ITG12_RS20255	COG3469	chitinase activity
ITG12_RS20270	COG0419	ATPase involved in DNA repair
ITG12_RS20275	COG0420	3'-5' exonuclease activity
ITG12_RS20295	COG3209	COG3209 Rhs family protein
ITG12_RS20365	COG0631	protein serine/threonine phosphatase activity
ITG12_RS20400	COG2815	serine threonine protein kinase
ITG12_RS20400	COG0515	serine threonine protein kinase
ITG12_RS20435	COG0346	lactoylglutathione lyase activity
ITG12_RS20440	COG1902	pentaerythritol trinitrate reductase activity
ITG12_RS20450	COG0463	Glycosyl transferase, family 2
ITG12_RS20450	COG1216	Glycosyl transferase, family 2
ITG12_RS20460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ITG12_RS20460	COG2755	lipolytic protein G-D-S-L family
ITG12_RS20470	COG5642	Protein of unknown function (DUF2384)
ITG12_RS20475	COG2067	long-chain fatty acid transport protein
ITG12_RS20520	COG0671	phosphoesterase, PA-phosphatase related
ITG12_RS20535	COG2962	Rard protein
ITG12_RS20545	COG2165	general secretion pathway protein
ITG12_RS20550	COG0835	chemotaxis
ITG12_RS20550	COG0784	Response regulator, receiver
ITG12_RS20555	COG0778	Nitroreductase
ITG12_RS20565	COG2197	response regulator
ITG12_RS20575	COG3706	GGDEF domain
ITG12_RS20580	COG2197	response regulator
ITG12_RS20585	COG3300	MHYT domain
ITG12_RS20585	COG5001	Diguanylate cyclase
ITG12_RS20605	COG4771	TonB-dependent receptor
ITG12_RS20670	COG1522	sequence-specific DNA binding
ITG12_RS20705	COG0515	serine threonine protein kinase
ITG12_RS20730	COG3501	Rhs element vgr protein
ITG12_RS20745	COG2204	response regulator
ITG12_RS20775	COG0739	heme binding
ITG12_RS20780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ITG12_RS20810	COG3069	C4-dicarboxylate transmembrane transporter activity
ITG12_RS20815	COG1704	LemA family
ITG12_RS20845	COG0641	radical SAM
ITG12_RS20865	COG3111	PFAM Bacterial OB fold (BOF) protein
ITG12_RS20870	COG1597	lipid kinase activity
ITG12_RS20885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG12_RS20895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG12_RS20955	COG0714	Associated with various cellular activities
ITG12_RS20960	COG0641	radical SAM
ITG12_RS20965	COG3119	arylsulfatase activity
ITG12_RS20970	COG0583	DNA-binding transcription factor activity
ITG12_RS20975	COG3063	Type IV pilus biogenesis stability protein PilW
ITG12_RS20980	COG3119	arylsulfatase activity
ITG12_RS20985	COG3119	arylsulfatase activity
ITG12_RS21015	COG2205	protein histidine kinase activity
ITG12_RS21015	COG0784	Response regulator, receiver
ITG12_RS21015	COG2198	Histidine kinase
ITG12_RS21020	COG1879	ABC-type sugar transport system periplasmic component
ITG12_RS21030	COG0210	DNA helicase
ITG12_RS21035	COG1289	transmembrane transporter activity
ITG12_RS21070	COG4206	TonB-dependent receptor
ITG12_RS21080	COG0789	Transcriptional regulator
ITG12_RS21085	COG4604	ABC transporter, ATP-binding protein
ITG12_RS21090	COG4605	iron ion homeostasis
ITG12_RS21095	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG12_RS21100	COG4607	ABC-type enterochelin transport system periplasmic component
ITG12_RS21130	COG1609	Transcriptional regulator
ITG12_RS21135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_RS21145	COG1172	Belongs to the binding-protein-dependent transport system permease family
ITG12_RS21150	COG1129	ABC transporter
ITG12_RS21160	COG5001	Diguanylate cyclase
ITG12_RS21165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ITG12_RS21170	COG1794	racemase activity, acting on amino acids and derivatives
ITG12_RS21175	COG1051	belongs to the nudix hydrolase family
ITG12_RS21180	COG0494	nUDIX hydrolase
ITG12_RS21240	COG2205	protein histidine kinase activity
ITG12_RS21240	COG0784	Response regulator, receiver
ITG12_RS21250	COG0784	Response regulator, receiver
ITG12_RS21250	COG2205	protein histidine kinase activity
ITG12_RS21255	COG3706	GGDEF domain
ITG12_RS21255	COG4251	negative regulation of phosphorylation
ITG12_RS21255	COG2203	Gaf domain
ITG12_RS21255	COG5001	Diguanylate cyclase
ITG12_RS21275	COG0330	HflC and HflK could
ITG12_RS21290	COG0517	IMP dehydrogenase activity
ITG12_RS21290	COG4175	Glycine betaine
ITG12_RS21295	COG4176	ABC-type proline glycine betaine transport system permease component
ITG12_RS21320	COG3706	GGDEF domain
ITG12_RS21335	COG0402	S-adenosylhomocysteine deaminase activity
ITG12_RS21355	COG2885	chlorophyll binding
ITG12_RS21395	COG0455	bacterial-type flagellum organization
ITG12_RS21405	COG4964	Belongs to the GSP D family
ITG12_RS21425	COG0583	DNA-binding transcription factor activity
ITG12_RS21430	COG1073	alpha beta
ITG12_RS21450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ITG12_RS21450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ITG12_RS21465	COG4989	oxidoreductase activity
ITG12_RS21490	COG1914	H( )-stimulated, divalent metal cation uptake system
ITG12_RS21505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ITG12_RS21565	COG2897	thiosulfate sulfurtransferase activity
ITG12_RS21590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG12_RS21600	COG2814	Major facilitator Superfamily
ITG12_RS21605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG12_RS21620	COG1612	heme a metabolic process
ITG12_RS21640	COG1845	cytochrome c oxidase, subunit III
ITG12_RS21645	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ITG12_RS21660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG12_RS21670	COG1280	lysine exporter protein (LysE YggA)
ITG12_RS21690	COG0179	Fumarylacetoacetate (FAA) hydrolase
ITG12_RS21705	COG0697	spore germination
ITG12_RS21720	COG2814	Major facilitator Superfamily
ITG12_RS21725	COG0583	DNA-binding transcription factor activity
ITG12_RS21745	COG2207	Transcriptional regulator
ITG12_RS21745	COG3708	Transcriptional regulator
ITG12_RS21755	COG1120	ATPase activity
ITG12_RS21760	COG5001	Diguanylate cyclase
ITG12_RS21765	COG0739	heme binding
ITG12_RS21785	COG3314	Sporulation integral membrane protein YlbJ
ITG12_RS21800	COG0814	amino acid
ITG12_RS21820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ITG12_RS21825	COG1072	(Pantothenic acid kinase))
ITG12_RS21835	COG1063	alcohol dehydrogenase
ITG12_RS21840	COG2213	PTS system mannitol-specific
ITG12_RS21845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_RS21850	COG2188	Transcriptional regulator
ITG12_RS21855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_RS21855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_RS21855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG12_RS21860	COG0383	alpha-mannosidase activity
ITG12_RS21865	COG1482	cell wall glycoprotein biosynthetic process
ITG12_RS21875	COG4989	oxidoreductase activity
ITG12_RS21895	COG0798	PFAM Bile acid sodium symporter
ITG12_RS21910	COG1881	PFAM PEBP family protein
ITG12_RS21920	COG0251	oxidation-reduction process
ITG12_RS21925	COG2706	6-phosphogluconolactonase activity
ITG12_RS21935	COG0800	Aldolase
ITG12_RS21940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_RS21945	COG4145	pantothenate transmembrane transporter activity
ITG12_RS21955	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ITG12_RS21970	COG0840	transmembrane signaling receptor activity
ITG12_RS21980	COG1131	(ABC) transporter
ITG12_RS21985	COG0842	Transport permease protein
ITG12_RS22005	COG3383	formate dehydrogenase (NAD+) activity
ITG12_RS22025	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_RS22065	COG3321	synthase
ITG12_RS22065	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS22065	COG0604	alcohol dehydrogenase
ITG12_RS22085	COG0494	nUDIX hydrolase
ITG12_RS22100	COG1858	cytochrome C peroxidase
ITG12_RS22110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG12_RS22120	COG2067	long-chain fatty acid transport protein
ITG12_RS22130	COG1505	serine-type exopeptidase activity
ITG12_RS22135	COG0488	(ABC) transporter
ITG12_RS22140	COG1720	tRNA m6t6A37 methyltransferase activity
ITG12_RS22160	COG0589	response to stress
ITG12_RS22190	COG1175	transmembrane transport
ITG12_RS22195	COG0395	ABC-type sugar transport system, permease component
ITG12_RS22200	COG3842	ATPase activity
ITG12_RS22230	COG0523	cobalamin synthesis protein
ITG12_RS22235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ITG12_RS22235	COG4451	ribulose bisphosphate carboxylase, small
ITG12_RS22240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITG12_RS22250	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG12_RS22255	COG1741	Belongs to the pirin family
ITG12_RS22260	COG1278	Cold shock
ITG12_RS22275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG12_RS22285	COG0583	DNA-binding transcription factor activity
ITG12_RS22305	COG2226	methyltransferase
ITG12_RS22315	COG1686	Belongs to the peptidase S11 family
ITG12_RS22320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_RS22325	COG0625	glutathione transferase activity
ITG12_RS22335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ITG12_RS22360	COG1278	Cold shock
ITG12_RS22385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ITG12_RS22395	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS22420	COG3746	phosphate-selective porin O and P
ITG12_RS22435	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS22445	COG0583	DNA-binding transcription factor activity
ITG12_RS22450	COG2207	Transcriptional regulator
ITG12_RS22450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG12_RS22455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG12_RS22505	COG0513	Belongs to the DEAD box helicase family
ITG12_RS22525	COG3501	Rhs element vgr protein
ITG12_RS22535	COG0583	DNA-binding transcription factor activity
ITG12_RS22545	COG0583	DNA-binding transcription factor activity
ITG12_RS22565	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS22570	COG2814	Major facilitator Superfamily
ITG12_RS22580	COG1902	pentaerythritol trinitrate reductase activity
ITG12_RS22590	COG3853	Toxic anion resistance protein (TelA)
ITG12_RS22600	COG2255	four-way junction helicase activity
ITG12_RS22615	COG3122	Protein conserved in bacteria
ITG12_RS22630	COG0583	DNA-binding transcription factor activity
ITG12_RS22635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG12_RS22650	COG0252	asparaginase activity
ITG12_RS22660	COG2807	transmembrane transport
ITG12_RS22670	COG0574	Belongs to the PEP-utilizing enzyme family
ITG12_RS22670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ITG12_RS22680	COG2197	response regulator
ITG12_RS22685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ITG12_RS22720	COG0583	DNA-binding transcription factor activity
ITG12_RS22725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG12_RS22745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITG12_RS22750	COG0786	glutamate:sodium symporter activity
ITG12_RS22780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG12_RS22785	COG0318	PFAM AMP-dependent synthetase and ligase
ITG12_RS22805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_RS22815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG12_RS22825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG12_RS22865	COG4948	Mandelate Racemase Muconate Lactonizing
ITG12_RS22870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG12_RS22890	COG1342	Belongs to the UPF0251 family
ITG12_RS22900	COG4176	ABC-type proline glycine betaine transport system permease component
ITG12_RS22905	COG4175	Glycine betaine
ITG12_RS22905	COG3448	diguanylate cyclase activity
ITG12_RS22920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ITG12_RS22925	COG0583	DNA-binding transcription factor activity
ITG12_RS22935	COG2801	Transposase and inactivated derivatives
ITG12_RS22940	COG2963	transposase activity
ITG12_RS22980	COG1335	isochorismatase
ITG12_RS22995	COG0753	catalase activity
ITG12_RS23020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITG12_RS23025	COG1263	PTS System
ITG12_RS23025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_RS23030	COG1609	Transcriptional regulator
ITG12_RS23035	COG1349	DNA-binding transcription factor activity
ITG12_RS23040	COG0346	lactoylglutathione lyase activity
ITG12_RS23045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_RS23045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_RS23055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG12_RS23060	COG3537	Alpha-1,2-mannosidase
ITG12_RS23065	COG3537	Alpha-1,2-mannosidase
ITG12_RS23075	COG3537	Alpha-1,2-mannosidase
ITG12_RS23080	COG3537	Alpha-1,2-mannosidase
ITG12_RS23120	COG1280	lysine exporter protein (LysE YggA)
ITG12_RS23125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG12_RS23140	COG3226	Transcriptional regulator
ITG12_RS23150	COG0583	DNA-binding transcription factor activity
ITG12_RS23165	COG0488	(ABC) transporter
ITG12_RS23185	COG0431	NADPH-dependent FMN reductase
ITG12_RS23190	COG0583	DNA-binding transcription factor activity
ITG12_RS23195	COG4628	conserved protein (DUF2132)
ITG12_RS23200	COG0488	(ABC) transporter
ITG12_RS23215	COG0346	lactoylglutathione lyase activity
ITG12_RS23220	COG0384	phenazine biosynthesis protein PhzF
ITG12_RS23235	COG3220	belongs to the UPF0276 family
ITG12_RS23250	COG1271	oxidase subunit
ITG12_RS23255	COG1294	oxidase, subunit
ITG12_RS23280	COG1882	Formate acetyltransferase
ITG12_RS23285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG12_RS23290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ITG12_RS23305	COG2205	protein histidine kinase activity
ITG12_RS23310	COG0745	RESPONSE REGULATOR receiver
ITG12_RS23320	COG0454	-acetyltransferase
ITG12_RS23325	COG0148	phosphopyruvate hydratase activity
ITG12_RS23335	COG2814	Major facilitator Superfamily
ITG12_RS23365	COG0583	DNA-binding transcription factor activity
ITG12_RS23370	COG2988	succinylglutamate desuccinylase activity
ITG12_RS23410	COG0628	permease
ITG12_RS23415	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG12_RS23420	COG2801	Transposase and inactivated derivatives
ITG12_RS23445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG12_RS23455	COG4628	conserved protein (DUF2132)
ITG12_RS23460	COG0583	DNA-binding transcription factor activity
ITG12_RS23485	COG1686	Belongs to the peptidase S11 family
ITG12_RS23505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG12_RS23510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG12_RS23535	COG0415	Belongs to the DNA photolyase family
ITG12_RS23540	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ITG12_RS23550	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG12_RS23555	COG2095	MarC family integral membrane protein
ITG12_RS23565	COG1596	polysaccharide export
ITG12_RS23575	COG0489	protein tyrosine kinase activity
ITG12_RS23575	COG3206	protein involved in exopolysaccharide biosynthesis
ITG12_RS23595	COG0583	DNA-binding transcription factor activity
ITG12_RS23625	COG1301	dicarboxylic acid transport
ITG12_RS23635	COG3339	Conserved Protein
ITG12_RS23640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG12_RS23645	COG0700	Nucleoside recognition
ITG12_RS23650	COG3366	ferrous iron transmembrane transporter activity
ITG12_RS23675	COG0366	Alpha amylase catalytic
ITG12_RS23680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITG12_RS23685	COG1473	amidohydrolase
ITG12_RS23690	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG12_RS23695	COG0583	DNA-binding transcription factor activity
ITG12_RS23700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ITG12_RS23705	COG1640	4-alpha-glucanotransferase
ITG12_RS23710	COG0058	SHG alpha-glucan phosphorylase activity
ITG12_RS23730	COG1999	signal sequence binding
ITG12_RS23745	COG1162	GTPase activity
ITG12_RS23750	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ITG12_RS23755	COG0673	inositol 2-dehydrogenase activity
ITG12_RS23780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_RS23785	COG0673	inositol 2-dehydrogenase activity
ITG12_RS23790	COG3962	Belongs to the TPP enzyme family
ITG12_RS23800	COG2814	Major facilitator Superfamily
ITG12_RS23800	COG0477	Major facilitator Superfamily
ITG12_RS23820	COG0183	Belongs to the thiolase family
ITG12_RS23825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ITG12_RS23850	COG0531	amino acid
ITG12_RS23855	COG1982	Orn Lys Arg decarboxylase major
ITG12_RS23875	COG2356	endonuclease I
ITG12_RS23880	COG0366	Alpha amylase catalytic
ITG12_RS23905	COG2199	diguanylate cyclase activity
ITG12_RS23905	COG2203	Gaf domain
ITG12_RS23935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ITG12_RS23950	COG2814	Major facilitator Superfamily
ITG12_RS23955	COG3214	Protein conserved in bacteria
ITG12_RS23965	COG4771	TonB-dependent receptor
ITG12_RS23970	COG0583	DNA-binding transcription factor activity
ITG12_RS23975	COG4607	ABC-type enterochelin transport system periplasmic component
ITG12_RS23980	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG12_RS23985	COG4605	iron ion homeostasis
ITG12_RS23990	COG4604	ABC transporter, ATP-binding protein
ITG12_RS23995	COG1309	transcriptional regulator
ITG12_RS24015	COG0739	heme binding
ITG12_RS24030	COG0800	Aldolase
ITG12_RS24035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_RS24040	COG1263	PTS System
ITG12_RS24040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_RS24040	COG2190	(PTS) system
ITG12_RS24050	COG2188	Transcriptional regulator
ITG12_RS24055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ITG12_RS24060	COG3876	Protein conserved in bacteria
ITG12_RS24065	COG1472	Belongs to the glycosyl hydrolase 3 family
ITG12_RS24085	COG3121	Chaperone
ITG12_RS24090	COG3188	usher protein
ITG12_RS24120	COG0612	Peptidase, M16
ITG12_RS24135	COG0826	peptidase U32
ITG12_RS24165	COG0583	DNA-binding transcription factor activity
ITG12_RS24180	COG1136	(ABC) transporter
ITG12_RS24185	COG0577	efflux transmembrane transporter activity
ITG12_RS24240	COG1764	response to oxidative stress
ITG12_RS24245	COG1846	Transcriptional regulator
ITG12_RS24255	COG3634	alkyl hydroperoxide reductase activity
ITG12_RS24275	COG2610	gluconate transmembrane transporter activity
ITG12_RS24280	COG3622	Belongs to the hyi family
ITG12_RS24285	COG0235	Class ii aldolase
ITG12_RS24290	COG3395	kinase activity
ITG12_RS24295	COG2084	Dehydrogenase
ITG12_RS24300	COG1349	DNA-binding transcription factor activity
ITG12_RS24320	COG0346	lactoylglutathione lyase activity
ITG12_RS24330	COG0583	DNA-binding transcription factor activity
ITG12_RS24335	COG1486	melibiose metabolic process
ITG12_RS24350	COG1522	sequence-specific DNA binding
ITG12_RS24365	COG2258	MOSC domain
ITG12_RS24370	COG2153	protein acetylation
ITG12_RS24380	COG1609	Transcriptional regulator
ITG12_RS24385	COG1757	Na H antiporter
ITG12_RS24390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITG12_RS24395	COG3713	MltA-interacting MipA family protein
ITG12_RS24400	COG0513	Belongs to the DEAD box helicase family
ITG12_RS24420	COG1312	Catalyzes the dehydration of D-mannonate
ITG12_RS24425	COG2186	Transcriptional regulator
ITG12_RS24435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG12_RS24445	COG0246	Mannitol dehydrogenase
ITG12_RS24450	COG1904	glucuronate isomerase
ITG12_RS24455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG12_RS24460	COG0800	Aldolase
ITG12_RS24485	COG0549	Belongs to the carbamate kinase family
ITG12_RS24490	COG0531	amino acid
ITG12_RS24495	COG2957	Belongs to the agmatine deiminase family
ITG12_RS24520	COG1132	(ABC) transporter
ITG12_RS24545	COG0406	alpha-ribazole phosphatase activity
ITG12_RS24570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG12_RS24640	COG4166	transmembrane transport
ITG12_RS24655	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ITG12_RS24660	COG1263	PTS System
ITG12_RS24660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG12_RS24665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG12_RS24675	COG0583	DNA-binding transcription factor activity
ITG12_RS24690	COG1444	tRNA N-acetyltransferase activity
ITG12_RS24715	COG4608	Belongs to the ABC transporter superfamily
ITG12_RS24720	COG0444	Belongs to the ABC transporter superfamily
ITG12_RS24730	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG12_RS24730	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ITG12_RS24755	COG0772	Belongs to the SEDS family
ITG12_RS24765	COG1566	PFAM secretion protein HlyD family protein
ITG12_RS24770	COG0583	DNA-binding transcription factor activity
ITG12_RS24780	COG1136	(ABC) transporter
ITG12_RS24800	COG3275	phosphorelay sensor kinase activity
ITG12_RS24805	COG3279	Response regulator of the LytR AlgR family
ITG12_RS24815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG12_RS24840	COG0786	glutamate:sodium symporter activity
ITG12_RS24845	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS24880	COG1131	(ABC) transporter
ITG12_RS24885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG12_RS24890	COG0786	glutamate:sodium symporter activity
ITG12_RS24910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG12_RS24925	COG0829	nickel cation binding
ITG12_RS24930	COG0831	urea catabolic process
ITG12_RS24935	COG0832	Belongs to the urease beta subunit family
ITG12_RS24940	COG0804	urea catabolic process
ITG12_RS24945	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ITG12_RS24950	COG0830	nickel cation binding
ITG12_RS24955	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ITG12_RS24965	COG2207	Transcriptional regulator
ITG12_RS24970	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ITG12_RS24980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG12_RS24995	COG0251	oxidation-reduction process
ITG12_RS25000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG12_RS25050	COG0561	phosphatase activity
ITG12_RS25055	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ITG12_RS25060	COG3623	hexulose-6-phosphate isomerase
ITG12_RS25095	COG2259	Doxx family
ITG12_RS25105	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ITG12_RS25110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ITG12_RS25125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITG12_RS25175	COG5001	Diguanylate cyclase
ITG12_RS25180	COG4580	involved in the transport of maltose and maltodextrins
ITG12_RS25185	COG1609	Transcriptional regulator
ITG12_RS25200	COG0395	ABC-type sugar transport system, permease component
ITG12_RS25205	COG2723	6-phospho-beta-galactosidase activity
ITG12_RS25210	COG3842	ATPase activity
ITG12_RS25215	COG1609	Transcriptional regulator
ITG12_RS25220	COG0534	Mate efflux family protein
ITG12_RS25225	COG0564	pseudouridine synthase activity
ITG12_RS25230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ITG12_RS25240	COG0561	phosphatase activity
ITG12_RS25250	COG2199	diguanylate cyclase activity
ITG12_RS25260	COG3152	Membrane
ITG12_RS25275	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ITG12_RS25295	COG0583	DNA-binding transcription factor activity
ITG12_RS25340	COG2076	Multidrug Resistance protein
ITG12_RS25355	COG0534	Mate efflux family protein
ITG12_RS25370	COG1357	PFAM Pentapeptide repeats (8 copies)
ITG12_RS25375	COG3047	cAMP biosynthetic process
ITG12_RS25380	COG2358	TRAP transporter, solute receptor (TAXI family
ITG12_RS25395	COG2814	Major facilitator Superfamily
ITG12_RS25415	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ITG12_RS25415	COG3408	Glycogen debranching enzyme
ITG12_RS25445	COG0583	DNA-binding transcription factor activity
ITG12_RS25500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG12_RS25510	COG0546	phosphoglycolate phosphatase activity
ITG12_RS25550	COG3835	regulator
ITG12_RS25555	COG1929	Belongs to the glycerate kinase type-1 family
ITG12_RS25560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG12_RS25605	COG0456	acetyltransferase
ITG12_RS25625	COG1028	Short-chain dehydrogenase reductase Sdr
ITG12_RS25635	COG3005	denitrification pathway
ITG12_RS25640	COG0243	molybdopterin cofactor binding
ITG12_RS25670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ITG12_RS25675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ITG12_RS25680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ITG12_RS25685	COG1116	anion transmembrane transporter activity
ITG12_RS25690	COG0351	phosphomethylpyrimidine kinase
ITG12_RS25695	COG0312	modulator of DNA gyrase
ITG12_RS25700	COG0312	modulator of DNA gyrase
ITG12_RS25755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG12_RS25765	COG0584	glycerophosphoryl diester phosphodiesterase
ITG12_RS25770	COG0745	RESPONSE REGULATOR receiver
ITG12_RS25790	COG0811	peptide transport
ITG12_RS25795	COG0811	peptide transport
ITG12_RS25800	COG0848	biopolymer transport protein
ITG12_RS25845	COG0803	Belongs to the bacterial solute-binding protein 9 family
ITG12_RS25850	COG1121	(ABC) transporter
ITG12_RS25855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG12_RS25870	COG1770	oligopeptidase
ITG12_RS25875	COG2814	Major facilitator Superfamily
ITG12_RS25880	COG0010	Belongs to the arginase family
ITG12_RS25885	COG1166	arginine decarboxylase activity
ITG12_RS25895	COG4067	protein conserved in archaea
ITG12_RS25895	COG0189	ligase activity
ITG12_RS25900	COG0189	ligase activity
ITG12_RS25920	COG0583	DNA-binding transcription factor activity
ITG12_RS25960	COG1114	Component of the transport system for branched-chain amino acids
ITG12_RS25975	COG0579	oxidoreductase
ITG12_RS25980	COG3179	chitinase
ITG12_RS26000	COG3033	Beta-eliminating lyase
ITG12_RS26015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG12_RS26020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG12_RS26040	COG3706	GGDEF domain
ITG12_RS26055	COG3706	GGDEF domain
ITG12_RS26060	COG0415	Belongs to the DNA photolyase family
ITG12_RS26065	COG3046	protein related to deoxyribodipyrimidine photolyase
ITG12_RS26080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_RS26080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG12_RS26085	COG1765	OsmC-like protein
ITG12_RS26110	COG1011	Hydrolase
ITG12_RS26150	COG3240	lipase activity
ITG12_RS26170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ITG12_RS26180	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG12_RS26185	COG3842	ATPase activity
ITG12_RS26210	COG2990	Protein conserved in bacteria
ITG12_RS26220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG12_RS26225	COG2866	Carboxypeptidase
ITG12_RS26235	COG0583	DNA-binding transcription factor activity
ITG12_RS26260	COG3104	oligopeptide transport
ITG12_RS26265	COG1760	l-serine dehydratase
ITG12_RS26290	COG1388	LysM domain
ITG12_RS26290	COG0741	lytic transglycosylase activity
ITG12_RS26310	COG1815	bacterial-type flagellum-dependent cell motility
ITG12_RS26315	COG1558	bacterial-type flagellum-dependent cell motility
ITG12_RS26320	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ITG12_RS26325	COG1749	Flagellar hook protein flgE
ITG12_RS26330	COG4787	bacterial-type flagellum-dependent cell motility
ITG12_RS26335	COG4786	Flagellar basal body rod
ITG12_RS26340	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ITG12_RS26345	COG1706	bacterial-type flagellum-dependent cell motility
ITG12_RS26355	COG4786	Flagellar basal body rod
ITG12_RS26355	COG1256	bacterial-type flagellum assembly
ITG12_RS26360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_RS26385	COG0583	DNA-binding transcription factor activity
ITG12_RS26405	COG1522	sequence-specific DNA binding
ITG12_RS26415	COG1473	amidohydrolase
ITG12_RS26420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG12_RS26430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG12_RS26435	COG0006	proline dipeptidase activity
ITG12_RS26445	COG1253	flavin adenine dinucleotide binding
ITG12_RS26450	COG3710	Transcriptional regulator
ITG12_RS26500	COG0384	phenazine biosynthesis protein PhzF
ITG12_RS26525	COG1360	Flagellar Motor Protein
ITG12_RS26530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ITG12_RS26535	COG1191	sigma factor activity
ITG12_RS26540	COG1580	Controls the rotational direction of flagella during chemotaxis
ITG12_RS26555	COG1516	flagellar protein fliS
ITG12_RS26560	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ITG12_RS26570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG12_RS26585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ITG12_RS26595	COG1987	bacterial-type flagellum assembly
ITG12_RS26655	COG2200	EAL domain
ITG12_RS26665	COG0583	DNA-binding transcription factor activity
ITG12_RS26715	COG0346	lactoylglutathione lyase activity
ITG12_RS26740	COG0745	RESPONSE REGULATOR receiver
ITG12_RS26765	COG0156	8-amino-7-oxononanoate synthase activity
ITG12_RS26770	COG1063	alcohol dehydrogenase
ITG12_RS26785	COG0668	transmembrane transport
ITG12_RS26800	COG1304	FMN binding
ITG12_RS26805	COG1620	l-lactate permease
ITG12_RS26810	COG0583	DNA-binding transcription factor activity
ITG12_RS26815	COG1505	serine-type exopeptidase activity
ITG12_RS26820	COG4172	Belongs to the ABC transporter superfamily
ITG12_RS26830	COG1067	ATP-dependent peptidase activity
ITG12_RS26840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG12_RS26860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG12_RS26865	COG0437	4 iron, 4 sulfur cluster binding
ITG12_RS26870	COG0348	domain, Protein
ITG12_RS26900	COG1122	ATPase activity
ITG12_RS26910	COG1566	PFAM secretion protein HlyD family protein
ITG12_RS26940	COG0813	purine-nucleoside phosphorylase activity
ITG12_RS26945	COG3272	Protein of unknown function (DUF1722)
ITG12_RS26950	COG0789	Transcriptional regulator
ITG12_RS26955	COG0415	Belongs to the DNA photolyase family
ITG12_RS26960	COG1388	LysM domain
ITG12_RS26960	COG1376	ErfK ybiS ycfS ynhG family protein
ITG12_RS26970	COG0513	Belongs to the DEAD box helicase family
ITG12_RS26980	COG1770	oligopeptidase
ITG12_RS26985	COG4771	TonB-dependent receptor
ITG12_RS27095	COG2200	EAL domain
ITG12_RS27110	COG2885	chlorophyll binding
ITG12_RS27110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ITG12_RS27175	COG2801	Transposase and inactivated derivatives
ITG12_RS27185	COG1192	Involved in chromosome partitioning
ITG12_RS27225	COG5268	conjugation
ITG12_RS27230	COG3451	type IV secretory pathway VirB4
ITG12_RS27240	COG4962	Type ii secretion system protein e
ITG12_RS27250	COG3701	Conjugal transfer protein
ITG12_RS27290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG12_RS27325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ITG12_RS27585	COG3210	domain, Protein
ITG12_RS27590	COG1192	Involved in chromosome partitioning