locus-tag	class	description
ITG10_RS00060	COG2885	chlorophyll binding
ITG10_RS00070	COG3706	GGDEF domain
ITG10_RS00075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ITG10_RS00080	COG0602	queuosine metabolic process
ITG10_RS00085	COG0561	phosphatase activity
ITG10_RS00120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ITG10_RS00125	COG0372	Belongs to the citrate synthase family
ITG10_RS00130	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ITG10_RS00165	COG4628	conserved protein (DUF2132)
ITG10_RS00175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITG10_RS00180	COG0363	glucosamine-6-phosphate deaminase activity
ITG10_RS00185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ITG10_RS00190	COG4565	transcriptional regulatory protein
ITG10_RS00195	COG3290	protein histidine kinase activity
ITG10_RS00210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG10_RS00225	COG1115	amino acid carrier protein
ITG10_RS00240	COG1115	amino acid carrier protein
ITG10_RS00260	COG1280	lysine exporter protein (LysE YggA)
ITG10_RS00265	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ITG10_RS00330	COG0730	response to heat
ITG10_RS00365	COG1247	-acetyltransferase
ITG10_RS00370	COG4977	sequence-specific DNA binding
ITG10_RS00395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG10_RS00395	COG4191	Histidine kinase
ITG10_RS00400	COG0471	metal ion transport
ITG10_RS00410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ITG10_RS00415	COG0494	nUDIX hydrolase
ITG10_RS00470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITG10_RS00480	COG3033	Beta-eliminating lyase
ITG10_RS00505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG10_RS00530	COG2176	DNA-directed DNA polymerase activity
ITG10_RS00535	COG0517	IMP dehydrogenase activity
ITG10_RS00540	COG2186	Transcriptional regulator
ITG10_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
ITG10_RS00550	COG2186	Transcriptional regulator
ITG10_RS00575	COG3344	reverse transcriptase
ITG10_RS00590	COG3344	reverse transcriptase
ITG10_RS00625	COG0840	transmembrane signaling receptor activity
ITG10_RS00640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG10_RS00650	COG3181	Tripartite tricarboxylate transporter family receptor
ITG10_RS00665	COG2186	Transcriptional regulator
ITG10_RS00675	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ITG10_RS00680	COG3639	organic phosphonate transmembrane transporter activity
ITG10_RS00705	COG1917	Cupin 2, conserved barrel domain protein
ITG10_RS00710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG10_RS00715	COG0800	Aldolase
ITG10_RS00720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG10_RS00740	COG3344	reverse transcriptase
ITG10_RS00745	COG0010	Belongs to the arginase family
ITG10_RS00750	COG1166	arginine decarboxylase activity
ITG10_RS00755	COG2226	methyltransferase
ITG10_RS00765	COG1309	transcriptional regulator
ITG10_RS00795	COG3097	Belongs to the UPF0267 family
ITG10_RS00800	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ITG10_RS00805	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ITG10_RS00825	COG4326	sporulation control protein
ITG10_RS00835	COG1228	amidohydrolase
ITG10_RS00840	COG0010	Belongs to the arginase family
ITG10_RS00845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ITG10_RS00850	COG2986	histidine ammonia-lyase
ITG10_RS00865	COG0247	lactate metabolic process
ITG10_RS00865	COG0277	FAD linked oxidase domain protein
ITG10_RS00900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ITG10_RS00915	COG0281	malic enzyme
ITG10_RS00920	COG2949	membrane
ITG10_RS00925	COG0471	metal ion transport
ITG10_RS00945	COG2203	Gaf domain
ITG10_RS00945	COG2199	diguanylate cyclase activity
ITG10_RS00960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITG10_RS00990	COG0492	ferredoxin-NADP+ reductase activity
ITG10_RS00995	COG4988	ABC transporter
ITG10_RS01000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ITG10_RS01005	COG3344	reverse transcriptase
ITG10_RS01020	COG3344	reverse transcriptase
ITG10_RS01025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG10_RS01030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG10_RS01055	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ITG10_RS01080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITG10_RS01085	COG3108	Peptidase M15
ITG10_RS01090	COG2989	Protein conserved in bacteria
ITG10_RS01115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG10_RS01125	COG3088	subunit of a heme lyase
ITG10_RS01125	COG4235	cytochrome complex assembly
ITG10_RS01135	COG1138	Cytochrome C-type biogenesis protein
ITG10_RS01140	COG3301	Polysulphide reductase, NrfD
ITG10_RS01145	COG0437	4 iron, 4 sulfur cluster binding
ITG10_RS01155	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ITG10_RS01175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG10_RS01180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG10_RS01185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG10_RS01205	COG0243	molybdopterin cofactor binding
ITG10_RS01210	COG0437	4 iron, 4 sulfur cluster binding
ITG10_RS01215	COG3302	dmso reductase anchor subunit
ITG10_RS01220	COG1058	Belongs to the CinA family
ITG10_RS01220	COG1546	Belongs to the CinA family
ITG10_RS01235	COG0019	diaminopimelate decarboxylase activity
ITG10_RS01275	COG0322	excinuclease ABC activity
ITG10_RS01280	COG2197	response regulator
ITG10_RS01285	COG0417	DNA replication proofreading
ITG10_RS01300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ITG10_RS01330	COG1187	pseudouridine synthase activity
ITG10_RS01335	COG0009	L-threonylcarbamoyladenylate synthase
ITG10_RS01340	COG0613	PHP domain protein
ITG10_RS01350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG10_RS01355	COG0512	Glutamine amidotransferase of anthranilate synthase
ITG10_RS01360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ITG10_RS01365	COG0135	phosphoribosylanthranilate isomerase activity
ITG10_RS01365	COG0134	indole-3-glycerol-phosphate synthase activity
ITG10_RS01370	COG0133	tryptophan synthase activity
ITG10_RS01375	COG0159	tryptophan synthase activity
ITG10_RS01380	COG0330	HflC and HflK could
ITG10_RS01390	COG1301	dicarboxylic acid transport
ITG10_RS01400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG10_RS01410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG10_RS01430	COG2917	probably involved in intracellular septation
ITG10_RS01435	COG1607	acyl-coa hydrolase
ITG10_RS01440	COG2350	Protein conserved in bacteria
ITG10_RS01450	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ITG10_RS01470	COG1032	radical SAM domain protein
ITG10_RS01475	COG1396	sequence-specific DNA binding
ITG10_RS01480	COG3135	benzoate transporter
ITG10_RS01490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ITG10_RS01495	COG0463	Glycosyl transferase, family 2
ITG10_RS01500	COG0745	RESPONSE REGULATOR receiver
ITG10_RS01520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG10_RS01525	COG0583	DNA-binding transcription factor activity
ITG10_RS01540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG10_RS01565	COG0786	glutamate:sodium symporter activity
ITG10_RS01580	COG0784	Response regulator, receiver
ITG10_RS01580	COG5002	protein histidine kinase activity
ITG10_RS01595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ITG10_RS01600	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ITG10_RS01605	COG2885	chlorophyll binding
ITG10_RS01610	COG0823	Involved in the tonB-independent uptake of proteins
ITG10_RS01625	COG0811	peptide transport
ITG10_RS01630	COG0824	Thioesterase
ITG10_RS01640	COG4890	Cyd operon protein YbgT
ITG10_RS01645	COG1294	oxidase, subunit
ITG10_RS01650	COG1271	oxidase subunit
ITG10_RS01655	COG2255	four-way junction helicase activity
ITG10_RS01660	COG0632	four-way junction helicase activity
ITG10_RS01665	COG0840	transmembrane signaling receptor activity
ITG10_RS01670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ITG10_RS01675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ITG10_RS01680	COG1801	Protein of unknown function DUF72
ITG10_RS01685	COG4106	trans-aconitate 2-methyltransferase activity
ITG10_RS01690	COG0500	methyltransferase
ITG10_RS01695	COG0189	ligase activity
ITG10_RS01695	COG4067	protein conserved in archaea
ITG10_RS01710	COG3383	formate dehydrogenase (NAD+) activity
ITG10_RS01715	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ITG10_RS01720	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ITG10_RS01725	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ITG10_RS01730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG10_RS01735	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ITG10_RS01740	COG0745	RESPONSE REGULATOR receiver
ITG10_RS01745	COG3381	protein complex oligomerization
ITG10_RS01750	COG1609	Transcriptional regulator
ITG10_RS01755	COG3070	regulator of competence-specific genes
ITG10_RS01775	COG0297	glycogen (starch) synthase activity
ITG10_RS01780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG10_RS01785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG10_RS01795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ITG10_RS01805	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ITG10_RS01810	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ITG10_RS01815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ITG10_RS01820	COG0542	response to heat
ITG10_RS01825	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ITG10_RS01830	COG1278	Cold shock
ITG10_RS01850	COG1199	ATP-dependent helicase activity
ITG10_RS01870	COG2850	peptidyl-arginine hydroxylation
ITG10_RS01875	COG0840	transmembrane signaling receptor activity
ITG10_RS01880	COG2814	Major facilitator Superfamily
ITG10_RS01885	COG1770	oligopeptidase
ITG10_RS01890	COG0708	Exodeoxyribonuclease III
ITG10_RS01900	COG4160	amino acid transport
ITG10_RS01925	COG1882	Formate acetyltransferase
ITG10_RS01935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG10_RS01940	COG3013	Belongs to the UPF0304 family
ITG10_RS01950	COG2766	serine protein kinase
ITG10_RS01955	COG2718	Belongs to the UPF0229 family
ITG10_RS01960	COG2719	SpoVR family
ITG10_RS01975	COG0616	signal peptide processing
ITG10_RS01980	COG1028	Short-chain dehydrogenase reductase Sdr
ITG10_RS01985	COG2801	Transposase and inactivated derivatives
ITG10_RS01990	COG2963	transposase activity
ITG10_RS02015	COG0784	Response regulator, receiver
ITG10_RS02015	COG0835	chemotaxis
ITG10_RS02020	COG1940	carbohydrate kinase activity
ITG10_RS02025	COG0469	pyruvate kinase activity
ITG10_RS02030	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG10_RS02045	COG2801	Transposase and inactivated derivatives
ITG10_RS02050	COG2801	Transposase and inactivated derivatives
ITG10_RS02065	COG0084	hydrolase, TatD family'
ITG10_RS02070	COG0470	DNA polymerase III
ITG10_RS02075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ITG10_RS02080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ITG10_RS02085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITG10_RS02110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG10_RS02115	COG0416	fatty acid biosynthetic process
ITG10_RS02120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ITG10_RS02125	COG1399	metal-binding, possibly nucleic acid-binding protein
ITG10_RS02135	COG0564	pseudouridine synthase activity
ITG10_RS02140	COG1530	ribonuclease E activity
ITG10_RS02145	COG0659	secondary active sulfate transmembrane transporter activity
ITG10_RS02150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ITG10_RS02155	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ITG10_RS02160	COG2982	Protein involved in outer membrane biogenesis
ITG10_RS02165	COG0572	uridine kinase
ITG10_RS02170	COG0489	protein tyrosine kinase activity
ITG10_RS02175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG10_RS02175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG10_RS02185	COG2186	Transcriptional regulator
ITG10_RS02190	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ITG10_RS02195	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITG10_RS02200	COG0653	protein targeting
ITG10_RS02205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG10_RS02210	COG3706	GGDEF domain
ITG10_RS02215	COG0366	Alpha amylase catalytic
ITG10_RS02225	COG3092	negative regulation of chromosome organization
ITG10_RS02230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITG10_RS02235	COG0857	belongs to the CobB CobQ family
ITG10_RS02235	COG0280	phosphate acetyltransferase
ITG10_RS02245	COG0435	Glutathione S-transferase
ITG10_RS02255	COG0444	Belongs to the ABC transporter superfamily
ITG10_RS02260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG10_RS02265	COG0601	transmembrane transport
ITG10_RS02275	COG0314	molybdopterin synthase activity
ITG10_RS02280	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ITG10_RS02285	COG0315	cyclic pyranopterin monophosphate synthase activity
ITG10_RS02290	COG0521	Mo-molybdopterin cofactor biosynthetic process
ITG10_RS02295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ITG10_RS02300	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ITG10_RS02310	COG2198	Histidine kinase
ITG10_RS02315	COG2204	response regulator
ITG10_RS02320	COG0556	nucleotide-excision repair
ITG10_RS02330	COG4657	Part of a membrane complex involved in electron transport
ITG10_RS02335	COG2878	Part of a membrane complex involved in electron transport
ITG10_RS02340	COG4656	Part of a membrane complex involved in electron transport
ITG10_RS02345	COG4658	electron transport chain
ITG10_RS02350	COG4659	FMN binding
ITG10_RS02355	COG4660	Part of a membrane complex involved in electron transport
ITG10_RS02360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ITG10_RS02365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ITG10_RS02370	COG0346	lactoylglutathione lyase activity
ITG10_RS02390	COG2056	Na+-H+ antiporter family
ITG10_RS02410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ITG10_RS02440	COG1454	alcohol dehydrogenase
ITG10_RS02440	COG1012	belongs to the aldehyde dehydrogenase family
ITG10_RS02445	COG2095	MarC family integral membrane protein
ITG10_RS02450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG10_RS02460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG10_RS02465	COG1757	Na H antiporter
ITG10_RS02480	COG3081	Nucleoid-associated protein
ITG10_RS02485	COG3082	Protein of unknown function (DUF1414)
ITG10_RS02520	COG0582	viral genome integration into host DNA
ITG10_RS02540	COG4372	Transposase
ITG10_RS02605	COG2801	Transposase and inactivated derivatives
ITG10_RS02620	COG0745	RESPONSE REGULATOR receiver
ITG10_RS02655	COG0840	transmembrane signaling receptor activity
ITG10_RS02660	COG0123	including yeast histone deacetylase and acetoin utilization protein
ITG10_RS02675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG10_RS02680	COG0778	Nitroreductase
ITG10_RS02685	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG10_RS02685	COG1902	pentaerythritol trinitrate reductase activity
ITG10_RS02690	COG0616	signal peptide processing
ITG10_RS02695	COG0252	asparaginase activity
ITG10_RS02700	COG3139	Protein of unknown function (DUF1315)
ITG10_RS02710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG10_RS02715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG10_RS02730	COG2226	methyltransferase
ITG10_RS02750	COG2983	Belongs to the UPF0260 family
ITG10_RS02765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ITG10_RS02770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ITG10_RS02775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ITG10_RS02780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ITG10_RS02785	COG2832	Protein of unknown function (DUF454)
ITG10_RS02795	COG0745	RESPONSE REGULATOR receiver
ITG10_RS02800	COG0583	DNA-binding transcription factor activity
ITG10_RS02805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ITG10_RS02810	COG1286	toxin biosynthetic process
ITG10_RS02815	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ITG10_RS02820	COG0285	dihydrofolate synthase activity
ITG10_RS02825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ITG10_RS02830	COG0101	tRNA pseudouridine synthase activity
ITG10_RS02840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG10_RS02845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG10_RS02850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ITG10_RS02860	COG0431	NADPH-dependent FMN reductase
ITG10_RS02870	COG3101	peptidyl-lysine hydroxylation
ITG10_RS02880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ITG10_RS02885	COG2153	protein acetylation
ITG10_RS02920	COG2391	methyltransferase activity
ITG10_RS02995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ITG10_RS03005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG10_RS03010	COG0583	DNA-binding transcription factor activity
ITG10_RS03015	COG2951	lytic endotransglycosylase activity
ITG10_RS03020	COG3100	YcgL domain-containing protein
ITG10_RS03025	COG0850	regulation of cytokinetic process
ITG10_RS03030	COG2894	cell division
ITG10_RS03035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ITG10_RS03040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ITG10_RS03045	COG0318	PFAM AMP-dependent synthetase and ligase
ITG10_RS03050	COG0596	Alpha beta hydrolase
ITG10_RS03065	COG1214	PFAM Peptidase M22, glycoprotease
ITG10_RS03070	COG1199	ATP-dependent helicase activity
ITG10_RS03090	COG0788	formyltetrahydrofolate deformylase activity
ITG10_RS03095	COG3102	Protein conserved in bacteria
ITG10_RS03100	COG0018	arginyl-trna synthetase
ITG10_RS03130	COG1918	ferrous iron import across plasma membrane
ITG10_RS03140	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ITG10_RS03145	COG1121	(ABC) transporter
ITG10_RS03150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG10_RS03160	COG0045	succinate-CoA ligase (ADP-forming) activity
ITG10_RS03165	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG10_RS03170	COG0567	Dehydrogenase, E1 component
ITG10_RS03175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITG10_RS03180	COG1053	succinate dehydrogenase
ITG10_RS03185	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ITG10_RS03200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ITG10_RS03215	COG0033	Phosphoglucomutase
ITG10_RS03220	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ITG10_RS03225	COG0596	Alpha beta hydrolase
ITG10_RS03250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ITG10_RS03255	COG1263	PTS System
ITG10_RS03255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG10_RS03255	COG2190	(PTS) system
ITG10_RS03260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ITG10_RS03265	COG1846	Transcriptional regulator
ITG10_RS03265	COG1940	carbohydrate kinase activity
ITG10_RS03270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG10_RS03270	COG4651	solute:proton antiporter activity
ITG10_RS03275	COG0367	asparagine synthase
ITG10_RS03280	COG0250	Participates in transcription elongation, termination and antitermination
ITG10_RS03285	COG3104	oligopeptide transport
ITG10_RS03290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ITG10_RS03295	COG0563	adenylate kinase activity
ITG10_RS03300	COG0326	Molecular chaperone. Has ATPase activity
ITG10_RS03305	COG3710	Transcriptional regulator
ITG10_RS03325	COG0622	Phosphoesterase
ITG10_RS03350	COG1090	epimerase
ITG10_RS03355	COG0300	oxidoreductase activity
ITG10_RS03360	COG3118	belongs to the thioredoxin family
ITG10_RS03365	COG0330	HflC and HflK could
ITG10_RS03375	COG0789	Transcriptional regulator
ITG10_RS03390	COG3344	reverse transcriptase
ITG10_RS03395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ITG10_RS03400	COG3115	cell septum assembly
ITG10_RS03405	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ITG10_RS03415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG10_RS03425	COG2190	(PTS) system
ITG10_RS03430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG10_RS03435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG10_RS03440	COG2837	iron assimilation
ITG10_RS03465	COG1393	Belongs to the ArsC family
ITG10_RS03470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG10_RS03485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ITG10_RS03490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ITG10_RS03495	COG2716	regulation of RNA biosynthetic process
ITG10_RS03525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ITG10_RS03570	COG4783	chaperone-mediated protein folding
ITG10_RS03575	COG1393	Belongs to the ArsC family
ITG10_RS03590	COG2801	Transposase and inactivated derivatives
ITG10_RS03595	COG2801	Transposase and inactivated derivatives
ITG10_RS03600	COG2963	transposase activity
ITG10_RS03620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ITG10_RS03625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ITG10_RS03630	COG0121	glutamine amidotransferase
ITG10_RS03635	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG10_RS03640	COG1960	acyl-CoA dehydrogenase activity
ITG10_RS03650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ITG10_RS03655	COG0328	RNA-DNA hybrid ribonuclease activity
ITG10_RS03660	COG2226	methyltransferase
ITG10_RS03665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITG10_RS03670	COG1388	LysM domain
ITG10_RS03670	COG0741	lytic transglycosylase activity
ITG10_RS03680	COG3021	interspecies interaction between organisms
ITG10_RS03690	COG0347	Belongs to the P(II) protein family
ITG10_RS03700	COG0037	tRNA processing
ITG10_RS03705	COG0825	malonyl-CoA metabolic process
ITG10_RS03710	COG0587	DNA-directed DNA polymerase activity
ITG10_RS03715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ITG10_RS03725	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG10_RS03730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ITG10_RS03735	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG10_RS03740	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ITG10_RS03750	COG0750	zinc metalloprotease
ITG10_RS03760	COG0575	Belongs to the CDS family
ITG10_RS03765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ITG10_RS03770	COG0233	cytoplasmic translational termination
ITG10_RS03775	COG0528	UMP kinase activity
ITG10_RS03785	COG0052	Belongs to the universal ribosomal protein uS2 family
ITG10_RS03790	COG0024	Methionine aminopeptidase
ITG10_RS03795	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ITG10_RS03805	COG0564	pseudouridine synthase activity
ITG10_RS03810	COG3098	single-species biofilm formation
ITG10_RS03835	COG1671	Belongs to the UPF0178 family
ITG10_RS03845	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG10_RS03855	COG0254	rRNA binding
ITG10_RS03860	COG1720	tRNA m6t6A37 methyltransferase activity
ITG10_RS03865	COG0442	prolyl-tRNA aminoacylation
ITG10_RS03895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITG10_RS03910	COG0366	Alpha amylase catalytic
ITG10_RS03915	COG1263	PTS System
ITG10_RS03915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG10_RS03920	COG1609	Transcriptional regulator
ITG10_RS03930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG10_RS03940	COG2011	ABC-type metal ion transport system permease component
ITG10_RS03945	COG1464	Belongs to the NlpA lipoprotein family
ITG10_RS03955	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ITG10_RS03965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ITG10_RS03965	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ITG10_RS03980	COG1611	Belongs to the LOG family
ITG10_RS03985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG10_RS03990	COG2963	transposase activity
ITG10_RS03995	COG2801	Transposase and inactivated derivatives
ITG10_RS04000	COG2801	Transposase and inactivated derivatives
ITG10_RS04015	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ITG10_RS04030	COG0583	DNA-binding transcription factor activity
ITG10_RS04040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG10_RS04040	COG0301	tRNA thio-modification
ITG10_RS04050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ITG10_RS04055	COG1722	exodeoxyribonuclease VII activity
ITG10_RS04060	COG0142	geranyltranstransferase activity
ITG10_RS04065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ITG10_RS04075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ITG10_RS04080	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ITG10_RS04085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITG10_RS04105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG10_RS04105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG10_RS04110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ITG10_RS04115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ITG10_RS04130	COG1073	alpha beta
ITG10_RS04135	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ITG10_RS04140	COG2252	PERMEase
ITG10_RS04145	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG10_RS04175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG10_RS04190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG10_RS04205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG10_RS04205	COG1263	PTS System
ITG10_RS04210	COG1609	Transcriptional regulator
ITG10_RS04220	COG2017	converts alpha-aldose to the beta-anomer
ITG10_RS04230	COG1085	galactose-1-phosphate uridylyltransferase
ITG10_RS04235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ITG10_RS04240	COG1609	Transcriptional regulator
ITG10_RS04250	COG2731	YhcH YjgK YiaL family protein
ITG10_RS04260	COG0531	amino acid
ITG10_RS04275	COG3250	beta-galactosidase activity
ITG10_RS04285	COG0395	ABC-type sugar transport system, permease component
ITG10_RS04290	COG1175	transmembrane transport
ITG10_RS04300	COG0534	Mate efflux family protein
ITG10_RS04310	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG10_RS04320	COG1609	Transcriptional regulator
ITG10_RS04330	COG0583	DNA-binding transcription factor activity
ITG10_RS04335	COG2059	Chromate
ITG10_RS04370	COG4964	Belongs to the GSP D family
ITG10_RS04405	COG1022	Amp-dependent synthetase and ligase
ITG10_RS04455	COG0583	DNA-binding transcription factor activity
ITG10_RS04465	COG0583	DNA-binding transcription factor activity
ITG10_RS04470	COG4628	conserved protein (DUF2132)
ITG10_RS04475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG10_RS04480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ITG10_RS04490	COG0560	Phosphoserine phosphatase
ITG10_RS04500	COG0813	purine-nucleoside phosphorylase activity
ITG10_RS04505	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ITG10_RS04510	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ITG10_RS04515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ITG10_RS04520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG10_RS04525	COG0084	hydrolase, TatD family'
ITG10_RS04535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ITG10_RS04550	COG3153	acetyltransferase
ITG10_RS04555	COG3154	lipid carrier protein
ITG10_RS04565	COG0826	peptidase U32
ITG10_RS04570	COG0826	peptidase U32
ITG10_RS04575	COG0534	Mate efflux family protein
ITG10_RS04585	COG2963	transposase activity
ITG10_RS04590	COG2801	Transposase and inactivated derivatives
ITG10_RS04600	COG1185	polyribonucleotide nucleotidyltransferase activity
ITG10_RS04605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ITG10_RS04610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ITG10_RS04615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ITG10_RS04620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ITG10_RS04625	COG0195	Participates in both transcription termination and antitermination
ITG10_RS04630	COG0779	Required for maturation of 30S ribosomal subunits
ITG10_RS04645	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG10_RS04650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG10_RS04655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ITG10_RS04660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ITG10_RS04665	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ITG10_RS04670	COG1534	Rna-binding protein
ITG10_RS04675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG10_RS04685	COG2027	D-alanyl-D-alanine carboxypeptidase
ITG10_RS04695	COG2239	Acts as a magnesium transporter
ITG10_RS04700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ITG10_RS04705	COG0739	heme binding
ITG10_RS04720	COG0316	Belongs to the HesB IscA family
ITG10_RS04725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ITG10_RS04730	COG0628	permease
ITG10_RS04735	COG2813	Specifically methylates the guanine in position
ITG10_RS04745	COG0747	negative chemotaxis
ITG10_RS04755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG10_RS04760	COG0444	Belongs to the ABC transporter superfamily
ITG10_RS04765	COG4608	Belongs to the ABC transporter superfamily
ITG10_RS04775	COG2971	BadF BadG BcrA BcrD
ITG10_RS04790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG10_RS04795	COG3842	ATPase activity
ITG10_RS04805	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG10_RS04810	COG0004	ammonium transporteR
ITG10_RS04825	COG1049	propionate catabolic process, 2-methylcitrate cycle
ITG10_RS04830	COG1752	Esterase of the alpha-beta hydrolase superfamily
ITG10_RS04835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITG10_RS04840	COG1643	Atp-dependent helicase
ITG10_RS04845	COG1489	DNA binding
ITG10_RS04865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG10_RS04870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ITG10_RS04875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ITG10_RS04880	COG0842	Transport permease protein
ITG10_RS04885	COG1131	(ABC) transporter
ITG10_RS04890	COG0659	secondary active sulfate transmembrane transporter activity
ITG10_RS04895	COG0288	reversible hydration of carbon dioxide
ITG10_RS04915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG10_RS04920	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG10_RS04925	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ITG10_RS04930	COG2186	Transcriptional regulator
ITG10_RS04940	COG0157	Belongs to the NadC ModD family
ITG10_RS04950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG10_RS04955	COG1459	type II secretion system
ITG10_RS04965	COG0237	dephospho-CoA kinase activity
ITG10_RS04970	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ITG10_RS05000	COG0335	large ribosomal subunit rRNA binding
ITG10_RS05005	COG0336	Belongs to the RNA methyltransferase TrmD family
ITG10_RS05010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ITG10_RS05020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ITG10_RS05025	COG4137	Cytochrome C assembly protein
ITG10_RS05030	COG4536	flavin adenine dinucleotide binding
ITG10_RS05035	COG1854	S-ribosylhomocysteine lyase activity
ITG10_RS05045	COG2918	glutathione biosynthetic process
ITG10_RS05050	COG0612	Peptidase, M16
ITG10_RS05055	COG1238	metal cluster binding
ITG10_RS05065	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ITG10_RS05070	COG0511	ligase activity, forming carbon-carbon bonds
ITG10_RS05070	COG5016	pyruvate
ITG10_RS05075	COG3630	sodium ion export across plasma membrane
ITG10_RS05135	COG0527	aspartate kinase activity
ITG10_RS05145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ITG10_RS05150	COG1546	Belongs to the CinA family
ITG10_RS05155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ITG10_RS05160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ITG10_RS05170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ITG10_RS05175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ITG10_RS05180	COG0585	pseudouridine synthase activity
ITG10_RS05190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ITG10_RS05195	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ITG10_RS05200	COG0148	phosphopyruvate hydratase activity
ITG10_RS05205	COG0504	CTP synthase activity
ITG10_RS05210	COG3956	TIGRFAM MazG family protein
ITG10_RS05215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG10_RS05220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ITG10_RS05225	COG2205	protein histidine kinase activity
ITG10_RS05225	COG3850	Histidine kinase
ITG10_RS05225	COG4999	Histidine kinase
ITG10_RS05225	COG3437	response regulator, receiver
ITG10_RS05230	COG0736	holo-[acyl-carrier-protein] synthase activity
ITG10_RS05235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ITG10_RS05240	COG1381	Involved in DNA repair and RecF pathway recombination
ITG10_RS05245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ITG10_RS05250	COG0571	ribonuclease III activity
ITG10_RS05260	COG0481	GTPase activity
ITG10_RS05280	COG1595	DNA-templated transcription, initiation
ITG10_RS05285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ITG10_RS05290	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ITG10_RS05295	COG0354	folic acid binding
ITG10_RS05310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG10_RS05315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG10_RS05320	COG3079	Belongs to the UPF0149 family
ITG10_RS05325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ITG10_RS05335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ITG10_RS05340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ITG10_RS05345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG10_RS05370	COG0668	transmembrane transport
ITG10_RS05375	COG0191	fructose-bisphosphate aldolase activity
ITG10_RS05390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG10_RS05395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ITG10_RS05405	COG3091	SprT-like family
ITG10_RS05410	COG2356	endonuclease I
ITG10_RS05415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ITG10_RS05420	COG0189	ligase activity
ITG10_RS05425	COG1678	Uncharacterized ACR, COG1678
ITG10_RS05430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ITG10_RS05450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ITG10_RS05455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ITG10_RS05460	COG0762	integral membrane protein
ITG10_RS05475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ITG10_RS05480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ITG10_RS05485	COG2066	Belongs to the glutaminase family
ITG10_RS05500	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ITG10_RS05505	COG0741	lytic transglycosylase activity
ITG10_RS05545	COG0840	transmembrane signaling receptor activity
ITG10_RS05665	COG0795	lipopolysaccharide-transporting ATPase activity
ITG10_RS05670	COG0795	lipopolysaccharide-transporting ATPase activity
ITG10_RS05675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ITG10_RS05680	COG2927	DNA polymerase III (CHI subunit)
ITG10_RS05685	COG0525	valine-tRNA ligase activity
ITG10_RS05695	COG0456	acetyltransferase
ITG10_RS05725	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ITG10_RS05730	COG0251	oxidation-reduction process
ITG10_RS05735	COG0204	Acyl-transferase
ITG10_RS05740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ITG10_RS05745	COG5007	Belongs to the BolA IbaG family
ITG10_RS05755	COG2854	intermembrane phospholipid transfer
ITG10_RS05760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG10_RS05765	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ITG10_RS05770	COG1127	ABC transporter
ITG10_RS05780	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ITG10_RS05780	COG0517	IMP dehydrogenase activity
ITG10_RS05785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ITG10_RS05795	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ITG10_RS05800	COG1137	ATPase activity
ITG10_RS05810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG10_RS05815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG10_RS05820	COG1660	Displays ATPase and GTPase activities
ITG10_RS05825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG10_RS05830	COG2239	Acts as a magnesium transporter
ITG10_RS05840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG10_RS05845	COG0729	surface antigen
ITG10_RS05850	COG2911	Protein conserved in bacteria
ITG10_RS05855	COG2105	PFAM AIG2 family protein
ITG10_RS05870	COG0312	modulator of DNA gyrase
ITG10_RS05875	COG3028	Belongs to the UPF0307 family
ITG10_RS05880	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ITG10_RS05885	COG1178	ABC-type Fe3 transport system permease component
ITG10_RS05895	COG0163	prenyltransferase activity
ITG10_RS05900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITG10_RS05905	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ITG10_RS05920	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ITG10_RS05955	COG0529	Catalyzes the synthesis of activated sulfate
ITG10_RS05960	COG0471	metal ion transport
ITG10_RS05960	COG3273	potassium ion transport
ITG10_RS05965	COG2895	sulfate adenylyltransferase (ATP) activity
ITG10_RS05970	COG0175	sulfate reduction
ITG10_RS05975	COG0737	Belongs to the 5'-nucleotidase family
ITG10_RS06025	COG2153	protein acetylation
ITG10_RS06035	COG3061	Opacity-associated protein A
ITG10_RS06035	COG3266	domain, Protein
ITG10_RS06040	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG10_RS06055	COG0203	ribosomal protein L17
ITG10_RS06060	COG0202	RNA polymerase activity
ITG10_RS06065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ITG10_RS06070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ITG10_RS06075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ITG10_RS06080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ITG10_RS06085	COG0201	protein transport
ITG10_RS06090	COG0200	Binds to the 23S rRNA
ITG10_RS06095	COG1841	ribosomal large subunit assembly
ITG10_RS06100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ITG10_RS06105	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ITG10_RS06110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ITG10_RS06115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ITG10_RS06120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ITG10_RS06125	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ITG10_RS06130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ITG10_RS06135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ITG10_RS06140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ITG10_RS06150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ITG10_RS06155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ITG10_RS06165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ITG10_RS06170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ITG10_RS06175	COG0089	rRNA binding
ITG10_RS06180	COG0088	Forms part of the polypeptide exit tunnel
ITG10_RS06185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ITG10_RS06200	COG2906	2 iron, 2 sulfur cluster binding
ITG10_RS06205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ITG10_RS06210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG10_RS06230	COG2923	Belongs to the DsrF TusC family
ITG10_RS06235	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ITG10_RS06240	COG2964	Protein conserved in bacteria
ITG10_RS06245	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG10_RS06255	COG2900	Belongs to the SlyX family
ITG10_RS06265	COG1047	Peptidyl-prolyl cis-trans
ITG10_RS06280	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG10_RS06285	COG0488	(ABC) transporter
ITG10_RS06295	COG0429	hydrolase of the alpha beta-hydrolase fold
ITG10_RS06300	COG3089	Belongs to the UPF0270 family
ITG10_RS06305	COG3954	Phosphoribulokinase
ITG10_RS06310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG10_RS06320	COG1012	belongs to the aldehyde dehydrogenase family
ITG10_RS06330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ITG10_RS06335	COG0512	Glutamine amidotransferase of anthranilate synthase
ITG10_RS06345	COG0180	Tryptophanyl-tRNA synthetase
ITG10_RS06350	COG0546	phosphoglycolate phosphatase activity
ITG10_RS06355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ITG10_RS06360	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ITG10_RS06370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ITG10_RS06405	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ITG10_RS06420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG10_RS06420	COG0678	peroxiredoxin activity
ITG10_RS06425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG10_RS06430	COG0251	oxidation-reduction process
ITG10_RS06440	COG0165	Argininosuccinate lyase
ITG10_RS06440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG10_RS06455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ITG10_RS06460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG10_RS06465	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ITG10_RS06475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITG10_RS06480	COG0460	homoserine dehydrogenase
ITG10_RS06480	COG0527	aspartate kinase activity
ITG10_RS06485	COG0626	cystathionine gamma-synthase activity
ITG10_RS06490	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ITG10_RS06495	COG0281	malic enzyme
ITG10_RS06500	COG0254	rRNA binding
ITG10_RS06505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ITG10_RS06510	COG1609	Transcriptional regulator
ITG10_RS06520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ITG10_RS06525	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ITG10_RS06530	COG1575	Belongs to the MenA family. Type 1 subfamily
ITG10_RS06535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG10_RS06540	COG3074	FtsZ-dependent cytokinesis
ITG10_RS06545	COG1494	fructose-1,6-bisphosphatase
ITG10_RS06560	COG3152	Membrane
ITG10_RS06570	COG0149	triose-phosphate isomerase activity
ITG10_RS06575	COG0205	6-phosphofructokinase activity
ITG10_RS06580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ITG10_RS06590	COG0745	RESPONSE REGULATOR receiver
ITG10_RS06595	COG2205	protein histidine kinase activity
ITG10_RS06605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ITG10_RS06615	COG1027	Aspartate ammonia-lyase
ITG10_RS06620	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG10_RS06625	COG1288	antiporter activity
ITG10_RS06635	COG0549	Belongs to the carbamate kinase family
ITG10_RS06640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ITG10_RS06645	COG0540	Belongs to the ATCase OTCase family
ITG10_RS06650	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ITG10_RS06655	COG1438	arginine binding
ITG10_RS06660	COG4232	protein-disulfide reductase activity
ITG10_RS06670	COG3263	regulation of cellular component size
ITG10_RS06680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG10_RS06695	COG0784	Response regulator, receiver
ITG10_RS06695	COG2198	Histidine kinase
ITG10_RS06695	COG2205	protein histidine kinase activity
ITG10_RS06700	COG2814	Major facilitator Superfamily
ITG10_RS06715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG10_RS06725	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ITG10_RS06730	COG0511	ligase activity, forming carbon-carbon bonds
ITG10_RS06735	COG0439	Biotin carboxylase
ITG10_RS06740	COG2264	protein methyltransferase activity
ITG10_RS06745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG10_RS06750	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ITG10_RS06755	COG0789	Transcriptional regulator
ITG10_RS06760	COG0138	bifunctional purine biosynthesis protein purh
ITG10_RS06765	COG0151	Belongs to the GarS family
ITG10_RS06780	COG1253	flavin adenine dinucleotide binding
ITG10_RS06785	COG3068	Protein conserved in bacteria
ITG10_RS06795	COG1573	uracil-dna glycosylase
ITG10_RS06810	COG2816	NAD+ diphosphatase activity
ITG10_RS06815	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ITG10_RS06830	COG0222	ribosome binding
ITG10_RS06835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ITG10_RS06840	COG0081	regulation of translation
ITG10_RS06850	COG0250	Participates in transcription elongation, termination and antitermination
ITG10_RS06855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG10_RS06860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ITG10_RS06885	COG1072	(Pantothenic acid kinase))
ITG10_RS06895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ITG10_RS06905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG10_RS06935	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ITG10_RS06950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ITG10_RS06965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG10_RS06970	COG0534	Mate efflux family protein
ITG10_RS06975	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ITG10_RS06980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ITG10_RS06985	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ITG10_RS06990	COG2937	Belongs to the GPAT DAPAT family
ITG10_RS06995	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ITG10_RS07000	COG3161	chorismate lyase activity
ITG10_RS07005	COG1580	Controls the rotational direction of flagella during chemotaxis
ITG10_RS07010	COG0705	Rhomboid family
ITG10_RS07015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG10_RS07025	COG2177	Part of the ABC transporter FtsEX involved in
ITG10_RS07030	COG2884	Cell division ATP-binding protein ftsE
ITG10_RS07035	COG0552	protein localization to endoplasmic reticulum
ITG10_RS07035	COG0552	protein localization to endoplasmic reticulum
ITG10_RS07040	COG0742	ribosomal rna small subunit methyltransferase
ITG10_RS07050	COG2095	MarC family integral membrane protein
ITG10_RS07090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG10_RS07095	COG0640	Transcriptional regulator
ITG10_RS07100	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG10_RS07105	COG1280	lysine exporter protein (LysE YggA)
ITG10_RS07110	COG2267	carboxylic ester hydrolase activity
ITG10_RS07115	COG0561	phosphatase activity
ITG10_RS07130	COG3148	PFAM DTW domain containing protein
ITG10_RS07140	COG2199	diguanylate cyclase activity
ITG10_RS07140	COG2200	EAL domain
ITG10_RS07140	COG3287	FIST C domain
ITG10_RS07145	COG2200	EAL domain
ITG10_RS07145	COG2199	diguanylate cyclase activity
ITG10_RS07145	COG3287	FIST C domain
ITG10_RS07150	COG1011	Hydrolase
ITG10_RS07155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ITG10_RS07165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ITG10_RS07170	COG0019	diaminopimelate decarboxylase activity
ITG10_RS07180	COG1965	Belongs to the frataxin family
ITG10_RS07185	COG3072	Adenylate cyclase
ITG10_RS07190	COG0181	hydroxymethylbilane synthase activity
ITG10_RS07195	COG1587	Uroporphyrinogen-III synthase
ITG10_RS07200	COG2959	enzyme of heme biosynthesis
ITG10_RS07260	COG2871	sodium ion transport
ITG10_RS07265	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ITG10_RS07280	COG3118	belongs to the thioredoxin family
ITG10_RS07285	COG0513	Belongs to the DEAD box helicase family
ITG10_RS07290	COG0248	Ppx GppA phosphatase
ITG10_RS07305	COG0861	Integral membrane protein TerC family
ITG10_RS07315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ITG10_RS07325	COG0514	ATP-dependent DNA helicase (RecQ)
ITG10_RS07330	COG2962	Rard protein
ITG10_RS07340	COG1280	lysine exporter protein (LysE YggA)
ITG10_RS07345	COG0405	Gamma-glutamyltransferase
ITG10_RS07355	COG0210	DNA helicase
ITG10_RS07365	COG3220	belongs to the UPF0276 family
ITG10_RS07395	COG0006	proline dipeptidase activity
ITG10_RS07395	COG0006	proline dipeptidase activity
ITG10_RS07405	COG2022	thiamine diphosphate biosynthetic process
ITG10_RS07410	COG2104	thiamine diphosphate biosynthetic process
ITG10_RS07415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ITG10_RS07420	COG0352	thiamine-phosphate diphosphorylase activity
ITG10_RS07425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ITG10_RS07435	COG2132	Multicopper oxidase
ITG10_RS07480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ITG10_RS07490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ITG10_RS07495	COG0408	coproporphyrinogen oxidase activity
ITG10_RS07500	COG0009	L-threonylcarbamoyladenylate synthase
ITG10_RS07505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ITG10_RS07510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ITG10_RS07515	COG0551	DNA topoisomerase type I activity
ITG10_RS07520	COG2922	Belongs to the Smg family
ITG10_RS07525	COG0758	DNA mediated transformation
ITG10_RS07545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITG10_RS07545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITG10_RS07550	COG0569	domain protein
ITG10_RS07555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG10_RS07565	COG1272	protein, Hemolysin III
ITG10_RS07570	COG4326	sporulation control protein
ITG10_RS07580	COG3084	Protein conserved in bacteria
ITG10_RS07590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITG10_RS07595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG10_RS07605	COG0606	chelatase, subunit chli
ITG10_RS07615	COG3978	acetolactate synthase activity
ITG10_RS07620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITG10_RS07625	COG0129	dihydroxy-acid dehydratase activity
ITG10_RS07635	COG0583	DNA-binding transcription factor activity
ITG10_RS07640	COG2814	Major facilitator Superfamily
ITG10_RS07645	COG3706	GGDEF domain
ITG10_RS07655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG10_RS07660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ITG10_RS07665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG10_RS07670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ITG10_RS07675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ITG10_RS07680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ITG10_RS07695	COG3312	ion transport
ITG10_RS07700	COG1475	DNA binding
ITG10_RS07705	COG1192	Involved in chromosome partitioning
ITG10_RS07710	COG0357	Ribosomal RNA small subunit methyltransferase G
ITG10_RS07715	COG0445	tRNA wobble uridine modification
ITG10_RS07720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG10_RS07730	COG0706	membrane insertase activity
ITG10_RS07735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ITG10_RS07740	COG0594	ribonuclease P activity
ITG10_RS07745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ITG10_RS07750	COG1126	abc transporter atp-binding protein
ITG10_RS07765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ITG10_RS07770	COG0592	DNA-directed DNA polymerase activity
ITG10_RS07775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ITG10_RS07780	COG0187	DNA topoisomerase II activity
ITG10_RS07785	COG0071	Belongs to the small heat shock protein (HSP20) family
ITG10_RS07790	COG3977	Valine--pyruvate aminotransferase
ITG10_RS07795	COG0366	Alpha amylase catalytic
ITG10_RS07800	COG0751	glycine-tRNA ligase activity
ITG10_RS07805	COG0752	glycyl-tRNA synthetase alpha subunit
ITG10_RS07810	COG2119	membrane
ITG10_RS07820	COG0425	Belongs to the sulfur carrier protein TusA family
ITG10_RS07835	COG0604	alcohol dehydrogenase
ITG10_RS07840	COG0183	Belongs to the thiolase family
ITG10_RS07845	COG1024	Enoyl-CoA hydratase
ITG10_RS07845	COG1250	3-hydroxyacyl-CoA dehydrogenase
ITG10_RS07850	COG1739	Uncharacterized protein family UPF0029
ITG10_RS07855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG10_RS07860	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ITG10_RS07920	COG0582	viral genome integration into host DNA
ITG10_RS08000	COG4964	Belongs to the GSP D family
ITG10_RS08025	COG3344	reverse transcriptase
ITG10_RS08035	COG0583	DNA-binding transcription factor activity
ITG10_RS08040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ITG10_RS08045	COG2960	long-chain fatty acid transporting porin activity
ITG10_RS08050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG10_RS08055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG10_RS08060	COG1309	transcriptional regulator
ITG10_RS08110	COG0601	transmembrane transport
ITG10_RS08115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG10_RS08195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG10_RS08200	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ITG10_RS08210	COG1522	sequence-specific DNA binding
ITG10_RS08215	COG5002	protein histidine kinase activity
ITG10_RS08215	COG5001	Diguanylate cyclase
ITG10_RS08220	COG0742	ribosomal rna small subunit methyltransferase
ITG10_RS08235	COG0589	response to stress
ITG10_RS08240	COG1528	Iron-storage protein
ITG10_RS08250	COG2081	HI0933 family
ITG10_RS08260	COG1322	Protein conserved in bacteria
ITG10_RS08265	COG2226	methyltransferase
ITG10_RS08270	COG3165	ubiquinone biosynthetic process from chorismate
ITG10_RS08275	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ITG10_RS08280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITG10_RS08285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITG10_RS08290	COG0805	protein transport
ITG10_RS08295	COG0084	hydrolase, TatD family'
ITG10_RS08310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG10_RS08310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG10_RS08335	COG3078	GTPase activator activity
ITG10_RS08360	COG3852	Histidine kinase
ITG10_RS08370	COG0174	glutamine synthetase
ITG10_RS08375	COG1217	gtp-binding protein TYPA
ITG10_RS08400	COG1295	ribonuclease BN
ITG10_RS08405	COG1490	D-aminoacyl-tRNA deacylase activity
ITG10_RS08410	COG0456	acetyltransferase
ITG10_RS08415	COG3344	reverse transcriptase
ITG10_RS08430	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ITG10_RS08440	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ITG10_RS08445	COG3031	protein transport across the cell outer membrane
ITG10_RS08455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG10_RS08460	COG1459	type II secretion system
ITG10_RS08465	COG2165	general secretion pathway protein
ITG10_RS08470	COG2165	general secretion pathway protein
ITG10_RS08475	COG2165	general secretion pathway protein
ITG10_RS08480	COG4795	General secretion pathway protein
ITG10_RS08485	COG3156	type II secretion system protein K
ITG10_RS08490	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG10_RS08495	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG10_RS08505	COG1218	3'(2'),5'-bisphosphate nucleotidase
ITG10_RS08510	COG0494	nUDIX hydrolase
ITG10_RS08515	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ITG10_RS08515	COG0316	Belongs to the HesB IscA family
ITG10_RS08525	COG0596	Alpha beta hydrolase
ITG10_RS08535	COG2183	response to ionizing radiation
ITG10_RS08540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG10_RS08555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ITG10_RS08560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG10_RS08565	COG1758	RNA polymerase activity
ITG10_RS08570	COG0194	GDP metabolic process
ITG10_RS08575	COG2252	PERMEase
ITG10_RS08585	COG1278	Cold shock
ITG10_RS08590	COG1561	YicC-like family, N-terminal region
ITG10_RS08595	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ITG10_RS08600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ITG10_RS08605	COG1560	Kdo2-lipid A biosynthetic process
ITG10_RS08610	COG1309	transcriptional regulator
ITG10_RS08620	COG2003	Belongs to the UPF0758 family
ITG10_RS08625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ITG10_RS08630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ITG10_RS08640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ITG10_RS08665	COG0859	PFAM glycosyl transferase family 9
ITG10_RS08670	COG3642	lipopolysaccharide core region biosynthetic process
ITG10_RS08675	COG1519	Transferase
ITG10_RS08685	COG0463	Glycosyl transferase, family 2
ITG10_RS08695	COG1086	Polysaccharide biosynthesis protein
ITG10_RS08700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ITG10_RS08715	COG0107	imidazoleglycerol-phosphate synthase activity
ITG10_RS08720	COG1083	cytidylyl-transferase
ITG10_RS08730	COG2089	acid synthase
ITG10_RS08745	COG1560	Kdo2-lipid A biosynthetic process
ITG10_RS08765	COG4942	peptidase
ITG10_RS08770	COG1045	serine acetyltransferase
ITG10_RS08780	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ITG10_RS08785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG10_RS08800	COG1091	dTDP-4-dehydrorhamnose reductase activity
ITG10_RS08840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ITG10_RS08865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG10_RS08885	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG10_RS08890	COG1596	polysaccharide export
ITG10_RS08920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ITG10_RS08925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ITG10_RS08965	COG1045	serine acetyltransferase
ITG10_RS09000	COG3273	potassium ion transport
ITG10_RS09000	COG0471	metal ion transport
ITG10_RS09005	COG0175	sulfate reduction
ITG10_RS09010	COG0529	Catalyzes the synthesis of activated sulfate
ITG10_RS09020	COG2895	sulfate adenylyltransferase (ATP) activity
ITG10_RS09025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ITG10_RS09030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ITG10_RS09225	COG0745	RESPONSE REGULATOR receiver
ITG10_RS09275	COG2433	Pfam Transposase IS66
ITG10_RS09305	COG3311	Transcriptional regulator
ITG10_RS09315	COG2161	toxin-antitoxin pair type II binding
ITG10_RS09350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ITG10_RS09365	COG2161	toxin-antitoxin pair type II binding
ITG10_RS09370	COG4115	mRNA cleavage
ITG10_RS09380	COG0534	Mate efflux family protein
ITG10_RS09385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ITG10_RS09400	COG0840	transmembrane signaling receptor activity
ITG10_RS09410	COG1285	pathogenesis
ITG10_RS09415	COG1509	lysine 2,3-aminomutase activity
ITG10_RS09420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ITG10_RS09430	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ITG10_RS09435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITG10_RS09440	COG1053	succinate dehydrogenase
ITG10_RS09445	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ITG10_RS09455	COG0840	transmembrane signaling receptor activity
ITG10_RS09460	COG0471	metal ion transport
ITG10_RS09460	COG0490	domain, Protein
ITG10_RS09465	COG0688	phosphatidylethanolamine metabolic process
ITG10_RS09470	COG1162	GTPase activity
ITG10_RS09560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ITG10_RS09565	COG0802	atpase or kinase
ITG10_RS09570	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITG10_RS09575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ITG10_RS09580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ITG10_RS09585	COG1923	regulation of RNA biosynthetic process
ITG10_RS09590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITG10_RS09595	COG0330	HflC and HflK could
ITG10_RS09600	COG0330	HflC and HflK could
ITG10_RS09605	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ITG10_RS09610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG10_RS09615	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ITG10_RS09620	COG0402	S-adenosylhomocysteine deaminase activity
ITG10_RS09625	COG0557	exoribonuclease II activity
ITG10_RS09630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG10_RS09645	COG0359	binds to the 23S rRNA
ITG10_RS09660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ITG10_RS09670	COG0432	Pfam Uncharacterised protein family UPF0047
ITG10_RS09675	COG0166	Belongs to the GPI family
ITG10_RS09685	COG0735	belongs to the Fur family
ITG10_RS09705	COG3385	transposase activity
ITG10_RS09715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG10_RS09720	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG10_RS09725	COG0175	sulfate reduction
ITG10_RS09810	COG0527	aspartate kinase activity
ITG10_RS09815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ITG10_RS09830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ITG10_RS09840	COG2197	response regulator
ITG10_RS09845	COG0629	single-stranded DNA binding
ITG10_RS09850	COG2200	EAL domain
ITG10_RS09850	COG2199	diguanylate cyclase activity
ITG10_RS09875	COG3409	Peptidoglycan-binding domain 1 protein
ITG10_RS09875	COG3267	Type II secretory pathway component ExeA
ITG10_RS09885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG10_RS09890	COG1459	type II secretion system
ITG10_RS09900	COG2165	general secretion pathway protein
ITG10_RS09905	COG2165	general secretion pathway protein
ITG10_RS09935	COG1077	Cell shape determining protein MreB Mrl
ITG10_RS09940	COG1792	Involved in formation and maintenance of cell shape
ITG10_RS09945	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ITG10_RS09950	COG0424	maF-like protein
ITG10_RS09965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ITG10_RS09970	COG0312	modulator of DNA gyrase
ITG10_RS09975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ITG10_RS09980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ITG10_RS09995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG10_RS10000	COG0589	response to stress
ITG10_RS10010	COG2358	TRAP transporter, solute receptor (TAXI family
ITG10_RS10015	COG1438	arginine binding
ITG10_RS10020	COG0039	L-malate dehydrogenase activity
ITG10_RS10035	COG0142	geranyltranstransferase activity
ITG10_RS10040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ITG10_RS10045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ITG10_RS10050	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ITG10_RS10055	COG2966	Psort location CytoplasmicMembrane, score
ITG10_RS10060	COG3610	response to peptide
ITG10_RS10070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ITG10_RS10075	COG2967	ApaG domain
ITG10_RS10080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ITG10_RS10085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ITG10_RS10090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG10_RS10095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ITG10_RS10100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ITG10_RS10115	COG0066	3-isopropylmalate dehydratase activity
ITG10_RS10125	COG0473	3-isopropylmalate dehydrogenase activity
ITG10_RS10130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ITG10_RS10170	COG1022	Amp-dependent synthetase and ligase
ITG10_RS10175	COG0028	Belongs to the TPP enzyme family
ITG10_RS10185	COG3706	GGDEF domain
ITG10_RS10195	COG0469	pyruvate kinase activity
ITG10_RS10200	COG1349	DNA-binding transcription factor activity
ITG10_RS10205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ITG10_RS10210	COG2873	o-acetylhomoserine
ITG10_RS10225	COG0358	DNA primase activity
ITG10_RS10230	COG1610	YqeY-like protein
ITG10_RS10235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ITG10_RS10240	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ITG10_RS10245	COG0596	Alpha beta hydrolase
ITG10_RS10250	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ITG10_RS10255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITG10_RS10265	COG1968	undecaprenyl-diphosphatase activity
ITG10_RS10275	COG3267	Type II secretory pathway component ExeA
ITG10_RS10275	COG3409	Peptidoglycan-binding domain 1 protein
ITG10_RS10285	COG4991	sh3 domain protein
ITG10_RS10290	COG0306	phosphate transporter
ITG10_RS10295	COG1392	Phosphate transport regulator
ITG10_RS10300	COG3025	triphosphatase activity
ITG10_RS10320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ITG10_RS10325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ITG10_RS10325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ITG10_RS10330	COG1538	Outer membrane efflux protein
ITG10_RS10335	COG0494	nUDIX hydrolase
ITG10_RS10340	COG3151	Protein conserved in bacteria
ITG10_RS10350	COG3150	esterase
ITG10_RS10365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITG10_RS10370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITG10_RS10375	COG3105	Protein conserved in bacteria
ITG10_RS10380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ITG10_RS10385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ITG10_RS10390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ITG10_RS10395	COG0723	plastoquinol--plastocyanin reductase activity
ITG10_RS10400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ITG10_RS10405	COG2857	Cytochrome c1
ITG10_RS10410	COG0625	glutathione transferase activity
ITG10_RS10415	COG2969	positive regulation of protein catabolic process
ITG10_RS10425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG10_RS10440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ITG10_RS10450	COG0275	rRNA processing
ITG10_RS10455	COG3116	cell division
ITG10_RS10460	COG0768	penicillin binding
ITG10_RS10465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ITG10_RS10470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ITG10_RS10475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ITG10_RS10480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ITG10_RS10485	COG0772	Belongs to the SEDS family
ITG10_RS10490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ITG10_RS10495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITG10_RS10500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ITG10_RS10505	COG0849	cell division
ITG10_RS10510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ITG10_RS10515	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ITG10_RS10520	COG0653	protein targeting
ITG10_RS10525	COG0494	nUDIX hydrolase
ITG10_RS10530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ITG10_RS10535	COG0505	Belongs to the CarA family
ITG10_RS10540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ITG10_RS10545	COG0730	response to heat
ITG10_RS10550	COG0583	DNA-binding transcription factor activity
ITG10_RS10565	COG2860	membrane
ITG10_RS10570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG10_RS10580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ITG10_RS10590	COG0493	'glutamate synthase
ITG10_RS10595	COG0067	glutamate synthase
ITG10_RS10595	COG0069	glutamate synthase activity
ITG10_RS10595	COG0070	glutamate synthase
ITG10_RS10605	COG0067	glutamate synthase
ITG10_RS10605	COG0069	glutamate synthase activity
ITG10_RS10605	COG0070	glutamate synthase
ITG10_RS10610	COG1242	4 iron, 4 sulfur cluster binding
ITG10_RS10615	COG5001	Diguanylate cyclase
ITG10_RS10615	COG3706	GGDEF domain
ITG10_RS10615	COG2203	Gaf domain
ITG10_RS10615	COG4251	negative regulation of phosphorylation
ITG10_RS10620	COG0784	Response regulator, receiver
ITG10_RS10620	COG2198	Histidine kinase
ITG10_RS10620	COG5002	protein histidine kinase activity
ITG10_RS10630	COG0745	RESPONSE REGULATOR receiver
ITG10_RS10640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG10_RS10655	COG0083	homoserine kinase activity
ITG10_RS10660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ITG10_RS10670	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ITG10_RS10675	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ITG10_RS10680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ITG10_RS10695	COG1115	amino acid carrier protein
ITG10_RS10700	COG3022	response to hydroperoxide
ITG10_RS10705	COG0513	Belongs to the DEAD box helicase family
ITG10_RS10710	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ITG10_RS10720	COG0716	FMN binding
ITG10_RS10725	COG4974	Belongs to the 'phage' integrase family
ITG10_RS10730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG10_RS10735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ITG10_RS10745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ITG10_RS10770	COG0494	nUDIX hydrolase
ITG10_RS10780	COG0730	response to heat
ITG10_RS10785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ITG10_RS10790	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ITG10_RS10800	COG1283	sodium-dependent phosphate transmembrane transporter activity
ITG10_RS10805	COG0583	DNA-binding transcription factor activity
ITG10_RS10810	COG0640	Transcriptional regulator
ITG10_RS10815	COG0268	Binds directly to 16S ribosomal RNA
ITG10_RS10820	COG0728	peptidoglycan biosynthetic process
ITG10_RS10825	COG0196	riboflavin kinase activity
ITG10_RS10830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ITG10_RS10840	COG1047	Peptidyl-prolyl cis-trans
ITG10_RS10845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ITG10_RS10850	COG3279	Response regulator of the LytR AlgR family
ITG10_RS10855	COG3275	phosphorelay sensor kinase activity
ITG10_RS10860	COG1966	Carbon starvation protein
ITG10_RS10870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ITG10_RS10875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ITG10_RS10880	COG2971	BadF BadG BcrA BcrD
ITG10_RS10890	COG1737	Transcriptional regulator
ITG10_RS10900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG10_RS10905	COG1605	Chorismate mutase
ITG10_RS10905	COG0287	Prephenate dehydrogenase
ITG10_RS10910	COG0739	heme binding
ITG10_RS10920	COG0488	(ABC) transporter
ITG10_RS10930	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ITG10_RS10935	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ITG10_RS10945	COG0077	Prephenate dehydratase
ITG10_RS10945	COG1605	Chorismate mutase
ITG10_RS10950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG10_RS10955	COG0741	lytic transglycosylase activity
ITG10_RS10960	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG10_RS10965	COG0564	pseudouridine synthase activity
ITG10_RS10970	COG1496	oxidoreductase activity
ITG10_RS11010	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ITG10_RS11025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG10_RS11030	COG0826	peptidase U32
ITG10_RS11035	COG2974	May be involved in recombination
ITG10_RS11040	COG0745	RESPONSE REGULATOR receiver
ITG10_RS11045	COG5002	protein histidine kinase activity
ITG10_RS11055	COG0248	Ppx GppA phosphatase
ITG10_RS11060	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ITG10_RS11070	COG0581	inorganic phosphate transmembrane transporter activity
ITG10_RS11075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG10_RS11080	COG0704	Plays a role in the regulation of phosphate uptake
ITG10_RS11100	COG3142	Participates in the control of copper homeostasis
ITG10_RS11105	COG0450	alkyl hydroperoxide reductase
ITG10_RS11110	COG0583	DNA-binding transcription factor activity
ITG10_RS11130	COG0517	IMP dehydrogenase activity
ITG10_RS11135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ITG10_RS11140	COG0343	queuine tRNA-ribosyltransferase activity
ITG10_RS11145	COG1862	Preprotein translocase
ITG10_RS11150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG10_RS11155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG10_RS11160	COG0483	inositol monophosphate 1-phosphatase activity
ITG10_RS11165	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ITG10_RS11170	COG1959	2 iron, 2 sulfur cluster binding
ITG10_RS11175	COG1104	cysteine desulfurase activity
ITG10_RS11180	COG0822	iron-sulfur transferase activity
ITG10_RS11190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ITG10_RS11195	COG0443	Heat shock 70 kDa protein
ITG10_RS11205	COG2975	iron-sulfur cluster assembly
ITG10_RS11210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ITG10_RS11215	COG0105	UTP biosynthetic process
ITG10_RS11220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ITG10_RS11230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ITG10_RS11235	COG0124	histidyl-tRNA synthetase
ITG10_RS11240	COG2976	Protein conserved in bacteria
ITG10_RS11245	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG10_RS11250	COG1160	GTP binding
ITG10_RS11260	COG3706	GGDEF domain
ITG10_RS11300	COG0831	urea catabolic process
ITG10_RS11305	COG0832	Belongs to the urease beta subunit family
ITG10_RS11310	COG0804	urea catabolic process
ITG10_RS11315	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ITG10_RS11330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ITG10_RS11335	COG1570	exodeoxyribonuclease VII activity
ITG10_RS11340	COG0516	GMP reductase activity
ITG10_RS11340	COG0517	IMP dehydrogenase activity
ITG10_RS11345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ITG10_RS11345	COG0519	Catalyzes the synthesis of GMP from XMP
ITG10_RS11355	COG1757	Na H antiporter
ITG10_RS11370	COG1584	GPR1 FUN34 yaaH family protein
ITG10_RS11375	COG1115	amino acid carrier protein
ITG10_RS11385	COG0204	Acyl-transferase
ITG10_RS11395	COG2264	protein methyltransferase activity
ITG10_RS11410	COG0189	ligase activity
ITG10_RS11410	COG4067	protein conserved in archaea
ITG10_RS11445	COG1028	Short-chain dehydrogenase reductase Sdr
ITG10_RS11465	COG1484	DNA-dependent DNA replication
ITG10_RS11480	COG1396	sequence-specific DNA binding
ITG10_RS11485	COG3550	peptidyl-serine autophosphorylation
ITG10_RS11500	COG1396	sequence-specific DNA binding
ITG10_RS11520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ITG10_RS11545	COG0582	viral genome integration into host DNA
ITG10_RS11560	COG2867	negative regulation of translational initiation
ITG10_RS11565	COG2914	Belongs to the UPF0125 (RnfH) family
ITG10_RS11570	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG10_RS11575	COG0497	DNA recombination
ITG10_RS11580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ITG10_RS11585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ITG10_RS11605	COG0443	Heat shock 70 kDa protein
ITG10_RS11610	COG0484	heat shock protein binding
ITG10_RS11640	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG10_RS11645	COG1253	flavin adenine dinucleotide binding
ITG10_RS11660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ITG10_RS11660	COG0047	phosphoribosylformylglycinamidine synthase activity
ITG10_RS11670	COG2171	N-acyltransferase activity
ITG10_RS11675	COG2095	MarC family integral membrane protein
ITG10_RS11690	COG3141	response to X-ray
ITG10_RS11705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ITG10_RS11710	COG1074	ATP-dependent DNA helicase activity
ITG10_RS11715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ITG10_RS11725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ITG10_RS11725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG10_RS11735	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ITG10_RS11740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ITG10_RS11745	COG2166	iron-sulfur cluster assembly
ITG10_RS11755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITG10_RS11760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ITG10_RS11765	COG3248	Nucleoside-binding outer membrane protein
ITG10_RS11780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG10_RS11790	COG2813	Specifically methylates the guanine in position
ITG10_RS11795	COG0271	Belongs to the BolA IbaG family
ITG10_RS11800	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG10_RS11805	COG1805	sodium ion transport
ITG10_RS11815	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG10_RS11820	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG10_RS11825	COG2871	sodium ion transport
ITG10_RS11830	COG1477	protein flavinylation
ITG10_RS11835	COG2991	Protein conserved in bacteria
ITG10_RS11845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITG10_RS11865	COG0733	neurotransmitter:sodium symporter activity
ITG10_RS11870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ITG10_RS11875	COG0321	lipoyl(octanoyl) transferase activity
ITG10_RS11885	COG1686	Belongs to the peptidase S11 family
ITG10_RS11890	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ITG10_RS11895	COG0772	Belongs to the SEDS family
ITG10_RS11900	COG0768	penicillin binding
ITG10_RS11905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ITG10_RS11910	COG0799	negative regulation of ribosome biogenesis
ITG10_RS11915	COG1466	dna polymerase III delta subunit
ITG10_RS11920	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ITG10_RS11925	COG0495	leucyl-tRNA aminoacylation
ITG10_RS11930	COG2888	peptidyl-tyrosine sulfation
ITG10_RS11935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ITG10_RS11940	COG4535	Mg2 and Co2 transporter CorC
ITG10_RS11945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ITG10_RS11950	COG1702	phosphate starvation-inducible protein PhoH
ITG10_RS11955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ITG10_RS11960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG10_RS11965	COG2706	6-phosphogluconolactonase activity
ITG10_RS12040	COG0193	aminoacyl-tRNA hydrolase activity
ITG10_RS12045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ITG10_RS12050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ITG10_RS12055	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ITG10_RS12060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ITG10_RS12065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ITG10_RS12070	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG10_RS12075	COG3094	Invasion gene expression up-regulator, SirB
ITG10_RS12080	COG2912	Transglutaminase-like superfamily
ITG10_RS12085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ITG10_RS12100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ITG10_RS12105	COG1187	pseudouridine synthase activity
ITG10_RS12110	COG2840	Smr protein MutS2
ITG10_RS12150	COG2608	mercury ion transmembrane transporter activity
ITG10_RS12150	COG2217	Heavy metal translocating P-type atpase
ITG10_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
ITG10_RS12205	COG2986	histidine ammonia-lyase
ITG10_RS12210	COG1216	Glycosyl transferase, family 2
ITG10_RS12230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG10_RS12235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG10_RS12285	COG3344	reverse transcriptase
ITG10_RS12300	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ITG10_RS12305	COG0784	Response regulator, receiver
ITG10_RS12305	COG0835	chemotaxis
ITG10_RS12310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ITG10_RS12315	COG1815	bacterial-type flagellum-dependent cell motility
ITG10_RS12330	COG1749	Flagellar hook protein flgE
ITG10_RS12335	COG4787	bacterial-type flagellum-dependent cell motility
ITG10_RS12345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ITG10_RS12350	COG1706	bacterial-type flagellum-dependent cell motility
ITG10_RS12355	COG3951	Flagellar rod assembly protein muramidase FlgJ
ITG10_RS12355	COG1705	Flagellar rod assembly protein muramidase FlgJ
ITG10_RS12370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG10_RS12375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG10_RS12380	COG3547	Transposase (IS116 IS110 IS902 family)
ITG10_RS12385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG10_RS12395	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ITG10_RS12405	COG1516	flagellar protein fliS
ITG10_RS12425	COG1677	Flagellar hook-basal body complex protein FliE
ITG10_RS12435	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ITG10_RS12485	COG1987	bacterial-type flagellum assembly
ITG10_RS12490	COG1684	flagellar biosynthetic protein fliR
ITG10_RS12525	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ITG10_RS12530	COG0643	Histidine kinase
ITG10_RS12530	COG0784	Response regulator, receiver
ITG10_RS12530	COG2198	Histidine kinase
ITG10_RS12535	COG2201	protein-glutamate methylesterase activity
ITG10_RS12540	COG1192	Involved in chromosome partitioning
ITG10_RS12550	COG0835	chemotaxis
ITG10_RS12560	COG4133	protoheme IX ABC transporter activity
ITG10_RS12565	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG10_RS12570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG10_RS12575	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG10_RS12580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ITG10_RS12585	COG1138	Cytochrome C-type biogenesis protein
ITG10_RS12590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITG10_RS12595	COG4235	cytochrome complex assembly
ITG10_RS12595	COG3088	subunit of a heme lyase
ITG10_RS12600	COG3088	subunit of a heme lyase
ITG10_RS12600	COG4235	cytochrome complex assembly
ITG10_RS12605	COG2853	Lipoprotein
ITG10_RS12610	COG2067	long-chain fatty acid transport protein
ITG10_RS12630	COG0183	Belongs to the thiolase family
ITG10_RS12635	COG1024	Enoyl-CoA hydratase
ITG10_RS12635	COG1250	3-hydroxyacyl-CoA dehydrogenase
ITG10_RS12645	COG2062	phosphohistidine phosphatase, SixA
ITG10_RS12655	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG10_RS12660	COG1280	lysine exporter protein (LysE YggA)
ITG10_RS12665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ITG10_RS12685	COG1175	transmembrane transport
ITG10_RS12695	COG3842	ATPase activity
ITG10_RS12700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITG10_RS12705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ITG10_RS12705	COG2070	2-Nitropropane dioxygenase
ITG10_RS12735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG10_RS12740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG10_RS12745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG10_RS12755	COG2204	response regulator
ITG10_RS12765	COG0544	peptidyl-prolyl cis-trans isomerase activity
ITG10_RS12770	COG0740	serine-type endopeptidase activity
ITG10_RS12775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ITG10_RS12780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ITG10_RS12785	COG0776	regulation of translation
ITG10_RS12790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG10_RS12795	COG1555	photosystem II stabilization
ITG10_RS12810	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ITG10_RS12815	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ITG10_RS12820	COG0436	Aminotransferase
ITG10_RS12825	COG1169	isochorismate synthase
ITG10_RS12830	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ITG10_RS12835	COG2267	carboxylic ester hydrolase activity
ITG10_RS12840	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ITG10_RS12860	COG2855	membrane
ITG10_RS12930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG10_RS12950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ITG10_RS12955	COG1522	sequence-specific DNA binding
ITG10_RS12965	COG1946	Acyl-CoA thioesterase
ITG10_RS12970	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ITG10_RS13015	COG1061	Type III restriction enzyme res subunit
ITG10_RS13050	COG1479	Protein of unknown function DUF262
ITG10_RS13085	COG0784	Response regulator, receiver
ITG10_RS13085	COG2205	protein histidine kinase activity
ITG10_RS13085	COG5002	protein histidine kinase activity
ITG10_RS13100	COG0210	DNA helicase
ITG10_RS13110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG10_RS13150	COG3341	Caulimovirus viroplasmin
ITG10_RS13150	COG0328	RNA-DNA hybrid ribonuclease activity
ITG10_RS13155	COG0438	transferase activity, transferring glycosyl groups
ITG10_RS13160	COG0463	Glycosyl transferase, family 2
ITG10_RS13160	COG1216	Glycosyl transferase, family 2
ITG10_RS13205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ITG10_RS13225	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ITG10_RS13235	COG0789	Transcriptional regulator
ITG10_RS13240	COG3394	polysaccharide catabolic process
ITG10_RS13245	COG1486	melibiose metabolic process
ITG10_RS13250	COG0583	DNA-binding transcription factor activity
ITG10_RS13280	COG3119	arylsulfatase activity
ITG10_RS13285	COG1609	Transcriptional regulator
ITG10_RS13300	COG2814	Major facilitator Superfamily
ITG10_RS13310	COG1760	l-serine dehydratase
ITG10_RS13315	COG1522	sequence-specific DNA binding
ITG10_RS13320	COG1280	lysine exporter protein (LysE YggA)
ITG10_RS13345	COG1263	PTS System
ITG10_RS13345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG10_RS13345	COG2190	(PTS) system
ITG10_RS13350	COG0583	DNA-binding transcription factor activity
ITG10_RS13370	COG3040	lipid binding
ITG10_RS13375	COG3038	cytochrome b561
ITG10_RS13390	COG0583	DNA-binding transcription factor activity
ITG10_RS13395	COG1309	transcriptional regulator
ITG10_RS13405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG10_RS13410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ITG10_RS13415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITG10_RS13420	COG1845	cytochrome c oxidase, subunit III
ITG10_RS13425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ITG10_RS13435	COG0681	Belongs to the peptidase S26 family
ITG10_RS13460	COG0583	DNA-binding transcription factor activity
ITG10_RS13465	COG0346	lactoylglutathione lyase activity
ITG10_RS13470	COG1902	pentaerythritol trinitrate reductase activity
ITG10_RS13475	COG0697	spore germination
ITG10_RS13500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG10_RS13530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ITG10_RS13530	COG0517	IMP dehydrogenase activity
ITG10_RS13530	COG0617	tRNA 3'-terminal CCA addition
ITG10_RS13540	COG2217	Heavy metal translocating P-type atpase
ITG10_RS13560	COG0537	adenosine 5'-monophosphoramidase activity
ITG10_RS13585	COG3150	esterase
ITG10_RS13590	COG1252	NADH dehydrogenase
ITG10_RS13605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ITG10_RS13615	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG10_RS13620	COG1136	(ABC) transporter
ITG10_RS13625	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG10_RS13635	COG0658	competence protein
ITG10_RS13635	COG2333	competence protein COMEC
ITG10_RS13640	COG1132	(ABC) transporter
ITG10_RS13645	COG1663	tetraacyldisaccharide 4'-kinase activity
ITG10_RS13650	COG2835	tetraacyldisaccharide 4'-kinase activity
ITG10_RS13655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ITG10_RS13660	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ITG10_RS13665	COG0539	negative regulation of cytoplasmic translation
ITG10_RS13670	COG0776	regulation of translation
ITG10_RS13675	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ITG10_RS13680	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ITG10_RS13685	COG0284	orotidine-5'-phosphate decarboxylase activity
ITG10_RS13700	COG0583	DNA-binding transcription factor activity
ITG10_RS13720	COG0686	Belongs to the AlaDH PNT family
ITG10_RS13725	COG1522	sequence-specific DNA binding
ITG10_RS13730	COG1674	ftsk spoiiie
ITG10_RS13735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ITG10_RS13740	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ITG10_RS13745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ITG10_RS13750	COG0745	RESPONSE REGULATOR receiver
ITG10_RS13760	COG2205	protein histidine kinase activity
ITG10_RS13760	COG0784	Response regulator, receiver
ITG10_RS13765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ITG10_RS13770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ITG10_RS13775	COG0156	8-amino-7-oxononanoate synthase activity
ITG10_RS13780	COG1073	alpha beta
ITG10_RS13780	COG2226	methyltransferase
ITG10_RS13795	COG0501	Belongs to the peptidase M48B family
ITG10_RS13800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ITG10_RS13805	COG2915	High frequency lysogenization protein hflD homolog
ITG10_RS13820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG10_RS13825	COG2916	Histone family protein nucleoid-structuring protein H-NS
ITG10_RS13830	COG1757	Na H antiporter
ITG10_RS13860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ITG10_RS13865	COG0131	Imidazoleglycerol-phosphate dehydratase
ITG10_RS13865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG10_RS13870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ITG10_RS13875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ITG10_RS13880	COG0107	imidazoleglycerol-phosphate synthase activity
ITG10_RS13885	COG0140	phosphoribosyl-ATP diphosphatase activity
ITG10_RS13885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ITG10_RS13890	COG3012	SEC-C Motif Domain Protein
ITG10_RS13895	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG10_RS13900	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG10_RS13905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG10_RS13910	COG0215	cysteine-tRNA ligase activity
ITG10_RS13940	COG2116	formate transmembrane transporter activity
ITG10_RS13945	COG0390	transport system, permease component
ITG10_RS13950	COG4459	periplasmic nitrate reductase
ITG10_RS13955	COG3005	denitrification pathway
ITG10_RS13970	COG1227	inorganic diphosphatase activity
ITG10_RS13985	COG4172	Belongs to the ABC transporter superfamily
ITG10_RS13995	COG4171	peptide transport system, permease
ITG10_RS14000	COG4168	peptide transport system, permease
ITG10_RS14005	COG4166	transmembrane transport
ITG10_RS14010	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ITG10_RS14015	COG1842	Phage shock protein A
ITG10_RS14025	COG1983	PspC domain protein
ITG10_RS14030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG10_RS14035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG10_RS14045	COG2818	Glycosylase
ITG10_RS14060	COG0626	cystathionine gamma-synthase activity
ITG10_RS14070	COG0733	neurotransmitter:sodium symporter activity
ITG10_RS14080	COG0564	pseudouridine synthase activity
ITG10_RS14085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG10_RS14085	COG0116	Belongs to the methyltransferase superfamily
ITG10_RS14090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ITG10_RS14095	COG4136	ATPase activity
ITG10_RS14100	COG4135	transport system, permease component
ITG10_RS14105	COG4134	Bacterial extracellular solute-binding protein
ITG10_RS14115	COG3313	Fe-S protein
ITG10_RS14135	COG0513	Belongs to the DEAD box helicase family
ITG10_RS14140	COG1280	lysine exporter protein (LysE YggA)
ITG10_RS14150	COG2866	Carboxypeptidase
ITG10_RS14160	COG3005	denitrification pathway
ITG10_RS14165	COG0243	molybdopterin cofactor binding
ITG10_RS14185	COG4176	ABC-type proline glycine betaine transport system permease component
ITG10_RS14190	COG2113	Glycine betaine
ITG10_RS14195	COG2801	Transposase and inactivated derivatives
ITG10_RS14215	COG0583	DNA-binding transcription factor activity
ITG10_RS14225	COG2995	paraquat-inducible protein a
ITG10_RS14230	COG3008	intermembrane lipid transfer
ITG10_RS14230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG10_RS14265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ITG10_RS14275	COG0586	Pfam SNARE associated Golgi protein
ITG10_RS14285	COG0642	Histidine kinase
ITG10_RS14300	COG1061	Type III restriction enzyme res subunit
ITG10_RS14310	COG2814	Major facilitator Superfamily
ITG10_RS14325	COG0702	epimerase
ITG10_RS14330	COG1858	cytochrome C peroxidase
ITG10_RS14335	COG0534	Mate efflux family protein
ITG10_RS14355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ITG10_RS14360	COG2885	chlorophyll binding
ITG10_RS14360	COG3047	cAMP biosynthetic process
ITG10_RS14380	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG10_RS14385	COG3273	potassium ion transport
ITG10_RS14385	COG2985	domain, Protein
ITG10_RS14390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG10_RS14400	COG1737	Transcriptional regulator
ITG10_RS14405	COG0076	glutamate decarboxylase activity
ITG10_RS14415	COG2431	L-lysine efflux transmembrane transporter activity
ITG10_RS14425	COG3070	regulator of competence-specific genes
ITG10_RS14435	COG2204	response regulator
ITG10_RS14440	COG3852	Histidine kinase
ITG10_RS14450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ITG10_RS14470	COG2258	MOSC domain
ITG10_RS14475	COG2176	DNA-directed DNA polymerase activity
ITG10_RS14490	COG1448	Aminotransferase
ITG10_RS14495	COG2770	Histidine kinase
ITG10_RS14495	COG3437	response regulator, receiver
ITG10_RS14505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG10_RS14515	COG0017	Asparaginyl-tRNA synthetase
ITG10_RS14520	COG0659	secondary active sulfate transmembrane transporter activity
ITG10_RS14530	COG0814	amino acid
ITG10_RS14535	COG1760	l-serine dehydratase
ITG10_RS14540	COG0814	amino acid
ITG10_RS14545	COG0494	nUDIX hydrolase
ITG10_RS14575	COG3106	COG3106 Predicted ATPase
ITG10_RS14590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG10_RS14605	COG0443	Heat shock 70 kDa protein
ITG10_RS14620	COG3706	GGDEF domain
ITG10_RS14635	COG3038	cytochrome b561
ITG10_RS14650	COG3710	Transcriptional regulator
ITG10_RS14690	COG3842	ATPase activity
ITG10_RS14695	COG3459	Glycosyltransferase 36 associated
ITG10_RS14710	COG1175	transmembrane transport
ITG10_RS14715	COG0395	ABC-type sugar transport system, permease component
ITG10_RS14730	COG1643	Atp-dependent helicase
ITG10_RS14775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ITG10_RS14780	COG0072	phenylalanine-tRNA ligase activity
ITG10_RS14780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG10_RS14805	COG0596	Alpha beta hydrolase
ITG10_RS14860	COG0302	gtp cyclohydrolase
ITG10_RS14865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITG10_RS14870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG10_RS14870	COG0302	gtp cyclohydrolase
ITG10_RS14885	COG1464	Belongs to the NlpA lipoprotein family
ITG10_RS14900	COG1522	sequence-specific DNA binding
ITG10_RS14905	COG2873	o-acetylhomoserine
ITG10_RS14940	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ITG10_RS14970	COG2205	protein histidine kinase activity
ITG10_RS14990	COG1342	Belongs to the UPF0251 family
ITG10_RS15020	COG0776	regulation of translation
ITG10_RS15050	COG2378	regulation of single-species biofilm formation
ITG10_RS15055	COG0840	transmembrane signaling receptor activity
ITG10_RS15065	COG0583	DNA-binding transcription factor activity
ITG10_RS15075	COG2175	clavaminate synthase activity
ITG10_RS15080	COG0488	(ABC) transporter
ITG10_RS15085	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ITG10_RS15100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG10_RS15110	COG2988	succinylglutamate desuccinylase activity
ITG10_RS15115	COG0523	cobalamin synthesis protein
ITG10_RS15125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITG10_RS15135	COG0776	regulation of translation
ITG10_RS15155	COG0500	methyltransferase
ITG10_RS15160	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ITG10_RS15165	COG0295	cytidine deaminase activity
ITG10_RS15170	COG1346	cytolysis
ITG10_RS15180	COG2925	Exonuclease
ITG10_RS15225	COG3568	Endonuclease Exonuclease Phosphatase
ITG10_RS15230	COG3122	Protein conserved in bacteria
ITG10_RS15255	COG4989	oxidoreductase activity
ITG10_RS15265	COG1823	symporter activity
ITG10_RS15270	COG0702	epimerase
ITG10_RS15275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ITG10_RS15280	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ITG10_RS15285	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ITG10_RS15305	COG2988	succinylglutamate desuccinylase activity
ITG10_RS15310	COG4139	cobalamin transport
ITG10_RS15315	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
ITG10_RS15335	COG0601	transmembrane transport
ITG10_RS15340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG10_RS15365	COG1247	-acetyltransferase
ITG10_RS15385	COG2814	Major facilitator Superfamily
ITG10_RS15390	COG0583	DNA-binding transcription factor activity
ITG10_RS15400	COG1451	nucleotide metabolic process
ITG10_RS15410	COG3063	Type IV pilus biogenesis stability protein PilW
ITG10_RS15415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ITG10_RS15430	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG10_RS15435	COG3706	GGDEF domain
ITG10_RS15485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG10_RS15515	COG0840	transmembrane signaling receptor activity
ITG10_RS15565	COG0454	-acetyltransferase
ITG10_RS15590	COG0346	lactoylglutathione lyase activity
ITG10_RS15670	COG1120	ATPase activity
ITG10_RS15785	COG0584	glycerophosphoryl diester phosphodiesterase
ITG10_RS15860	COG0517	IMP dehydrogenase activity
ITG10_RS15925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ITG10_RS15935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG10_RS15935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG10_RS16015	COG1765	OsmC-like protein
ITG10_RS16050	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG10_RS16055	COG0583	DNA-binding transcription factor activity
ITG10_RS16090	COG0653	protein targeting
ITG10_RS16095	COG0546	phosphoglycolate phosphatase activity
ITG10_RS16160	COG1126	abc transporter atp-binding protein
ITG10_RS16275	COG0583	DNA-binding transcription factor activity
ITG10_RS16300	COG1742	UPF0060 membrane protein
ITG10_RS16330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ITG10_RS16360	COG4160	amino acid transport
ITG10_RS16365	COG4215	(ABC) transporter
ITG10_RS16370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG10_RS16375	COG1126	abc transporter atp-binding protein
ITG10_RS16390	COG0826	peptidase U32
ITG10_RS16430	COG1028	Short-chain dehydrogenase reductase Sdr
ITG10_RS16440	COG0546	phosphoglycolate phosphatase activity
ITG10_RS16445	COG0653	protein targeting
ITG10_RS16475	COG0583	DNA-binding transcription factor activity
ITG10_RS16480	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG10_RS16495	COG1619	proteins homologs of microcin C7 resistance protein MccF
ITG10_RS16510	COG1765	OsmC-like protein
ITG10_RS16525	COG0454	-acetyltransferase
ITG10_RS16590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG10_RS16590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG10_RS16600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ITG10_RS16625	COG4974	Belongs to the 'phage' integrase family
ITG10_RS16640	COG0517	IMP dehydrogenase activity
ITG10_RS16650	COG0110	maltose O-acetyltransferase activity
ITG10_RS16660	COG1187	pseudouridine synthase activity
ITG10_RS16700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG10_RS16710	COG0584	glycerophosphoryl diester phosphodiesterase
ITG10_RS16715	COG2271	Major facilitator Superfamily
ITG10_RS16735	COG4774	siderophore transport
ITG10_RS16755	COG4615	Cyclic peptide transporter
ITG10_RS16765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG10_RS16770	COG1120	ATPase activity
ITG10_RS16795	COG0589	response to stress
ITG10_RS16800	COG0415	Belongs to the DNA photolyase family
ITG10_RS16805	COG3046	protein related to deoxyribodipyrimidine photolyase
ITG10_RS16825	COG3547	Transposase (IS116 IS110 IS902 family)
ITG10_RS16830	COG0419	ATPase involved in DNA repair
ITG10_RS16835	COG0420	3'-5' exonuclease activity
ITG10_RS16840	COG0346	lactoylglutathione lyase activity
ITG10_RS16865	COG0454	-acetyltransferase
ITG10_RS16870	COG2199	diguanylate cyclase activity
ITG10_RS16880	COG4771	TonB-dependent receptor
ITG10_RS16890	COG3469	chitinase activity
ITG10_RS16940	COG2204	response regulator
ITG10_RS16950	COG3448	diguanylate cyclase activity
ITG10_RS16950	COG4175	Glycine betaine
ITG10_RS16955	COG4176	ABC-type proline glycine betaine transport system permease component
ITG10_RS16975	COG2885	chlorophyll binding
ITG10_RS16985	COG1793	dna ligase
ITG10_RS16990	COG0534	Mate efflux family protein
ITG10_RS16995	COG0307	riboflavin synthase, alpha
ITG10_RS17005	COG3001	Fructosamine kinase
ITG10_RS17015	COG0791	NLP P60 protein
ITG10_RS17020	COG0840	transmembrane signaling receptor activity
ITG10_RS17030	COG3148	PFAM DTW domain containing protein
ITG10_RS17035	COG1940	carbohydrate kinase activity
ITG10_RS17045	COG3706	GGDEF domain
ITG10_RS17050	COG0303	'Molybdopterin
ITG10_RS17055	COG0746	molybdenum cofactor guanylyltransferase activity
ITG10_RS17060	COG3842	ATPase activity
ITG10_RS17065	COG4662	Binding-protein-dependent transport system inner membrane component
ITG10_RS17080	COG4191	Histidine kinase
ITG10_RS17100	COG0488	(ABC) transporter
ITG10_RS17110	COG4890	Cyd operon protein YbgT
ITG10_RS17115	COG1294	oxidase, subunit
ITG10_RS17120	COG1271	oxidase subunit
ITG10_RS17135	COG3220	belongs to the UPF0276 family
ITG10_RS17150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ITG10_RS17170	COG3381	protein complex oligomerization
ITG10_RS17180	COG0243	molybdopterin cofactor binding
ITG10_RS17180	COG3383	formate dehydrogenase (NAD+) activity
ITG10_RS17185	COG0437	4 iron, 4 sulfur cluster binding
ITG10_RS17200	COG0004	ammonium transporteR
ITG10_RS17205	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ITG10_RS17215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ITG10_RS17225	COG1177	transmembrane transport
ITG10_RS17235	COG3842	ATPase activity
ITG10_RS17255	COG0037	tRNA processing
ITG10_RS17260	COG0589	response to stress
ITG10_RS17265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG10_RS17280	COG2217	Heavy metal translocating P-type atpase
ITG10_RS17290	COG2010	Cytochrome c
ITG10_RS17305	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG10_RS17320	COG0784	Response regulator, receiver
ITG10_RS17320	COG2205	protein histidine kinase activity
ITG10_RS17365	COG4128	Pfam Zonular occludens toxin
ITG10_RS17375	COG0464	growth
ITG10_RS17415	COG3120	sequence-specific DNA binding
ITG10_RS17420	COG1067	ATP-dependent peptidase activity
ITG10_RS17440	COG0488	(ABC) transporter
ITG10_RS17450	COG0116	Belongs to the methyltransferase superfamily
ITG10_RS17450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG10_RS17460	COG0167	dihydroorotate dehydrogenase activity
ITG10_RS17465	COG2902	Dehydrogenase
ITG10_RS17475	COG0308	aminopeptidase N
ITG10_RS17490	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ITG10_RS17495	COG1956	GAF domain-containing protein
ITG10_RS17500	COG1132	(ABC) transporter
ITG10_RS17505	COG2995	paraquat-inducible protein a
ITG10_RS17510	COG3008	intermembrane lipid transfer
ITG10_RS17515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITG10_RS17515	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ITG10_RS17520	COG2996	Protein conserved in bacteria
ITG10_RS17535	COG0574	Belongs to the PEP-utilizing enzyme family
ITG10_RS17535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ITG10_RS17540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG10_RS17545	COG1666	GTP binding
ITG10_RS17555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG10_RS17560	COG4597	amino acid ABC transporter
ITG10_RS17565	COG0765	amino acid transport
ITG10_RS17570	COG1126	abc transporter atp-binding protein
ITG10_RS17575	COG0670	Belongs to the BI1 family
ITG10_RS17580	COG2920	part of a sulfur-relay system
ITG10_RS17585	COG1254	Belongs to the acylphosphatase family
ITG10_RS17590	COG0840	transmembrane signaling receptor activity
ITG10_RS17615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ITG10_RS17625	COG0402	S-adenosylhomocysteine deaminase activity
ITG10_RS17635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ITG10_RS17640	COG0789	Transcriptional regulator
ITG10_RS17655	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ITG10_RS17680	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
ITG10_RS17685	COG4266	Belongs to the allantoicase family
ITG10_RS17705	COG2252	PERMEase
ITG10_RS17730	COG0402	S-adenosylhomocysteine deaminase activity
ITG10_RS17755	COG2084	Dehydrogenase
ITG10_RS17760	COG3622	Belongs to the hyi family
ITG10_RS17765	COG3960	tartronate-semialdehyde synthase activity
ITG10_RS17770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ITG10_RS17780	COG1846	Transcriptional regulator
ITG10_RS17840	COG4964	Belongs to the GSP D family
ITG10_RS17930	COG1067	ATP-dependent peptidase activity
ITG10_RS17940	COG4172	Belongs to the ABC transporter superfamily
ITG10_RS17945	COG1609	Transcriptional regulator
ITG10_RS17955	COG2017	converts alpha-aldose to the beta-anomer
ITG10_RS17960	COG3459	Glycosyltransferase 36 associated
ITG10_RS17965	COG3842	ATPase activity
ITG10_RS17970	COG2723	6-phospho-beta-galactosidase activity
ITG10_RS17975	COG0395	ABC-type sugar transport system, permease component
ITG10_RS17995	COG0840	transmembrane signaling receptor activity
ITG10_RS18005	COG1505	serine-type exopeptidase activity
ITG10_RS18010	COG0583	DNA-binding transcription factor activity
ITG10_RS18015	COG1620	l-lactate permease
ITG10_RS18020	COG1304	FMN binding
ITG10_RS18040	COG0747	negative chemotaxis
ITG10_RS18045	COG4172	Belongs to the ABC transporter superfamily
ITG10_RS18055	COG0534	Mate efflux family protein
ITG10_RS18060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG10_RS18060	COG2207	Transcriptional regulator
ITG10_RS18065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG10_RS18075	COG1054	Belongs to the UPF0176 family
ITG10_RS18090	COG0745	RESPONSE REGULATOR receiver
ITG10_RS18115	COG2271	Major facilitator Superfamily
ITG10_RS18120	COG3851	Histidine kinase
ITG10_RS18125	COG2197	response regulator
ITG10_RS18155	COG1741	Belongs to the pirin family
ITG10_RS18160	COG3123	guanosine phosphorylase activity
ITG10_RS18175	COG0596	Alpha beta hydrolase
ITG10_RS18220	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ITG10_RS18225	COG0700	Nucleoside recognition
ITG10_RS18230	COG3366	ferrous iron transmembrane transporter activity
ITG10_RS18245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ITG10_RS18255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ITG10_RS18260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ITG10_RS18280	COG0363	glucosamine-6-phosphate deaminase activity
ITG10_RS18285	COG3722	fumarate hydratase activity
ITG10_RS18290	COG0246	Mannitol dehydrogenase
ITG10_RS18295	COG2213	PTS system mannitol-specific
ITG10_RS18295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG10_RS18315	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG10_RS18320	COG0786	glutamate:sodium symporter activity
ITG10_RS18335	COG1942	4-Oxalocrotonate Tautomerase
ITG10_RS18345	COG1595	DNA-templated transcription, initiation
ITG10_RS18350	COG3806	Anti-sigma factor
ITG10_RS18360	COG0415	Belongs to the DNA photolyase family
ITG10_RS18370	COG4221	oxidoreductase activity
ITG10_RS18385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ITG10_RS18410	COG0724	RNA recognition motif
ITG10_RS18420	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITG10_RS18435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG10_RS18435	COG1263	PTS System
ITG10_RS18440	COG2205	protein histidine kinase activity
ITG10_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
ITG10_RS18460	COG2814	Major facilitator Superfamily
ITG10_RS18465	COG1902	pentaerythritol trinitrate reductase activity
ITG10_RS18485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG10_RS18490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG10_RS18500	COG0612	Peptidase, M16
ITG10_RS18505	COG0612	Peptidase, M16
ITG10_RS18510	COG3279	Response regulator of the LytR AlgR family
ITG10_RS18515	COG3275	phosphorelay sensor kinase activity
ITG10_RS18535	COG1136	(ABC) transporter
ITG10_RS18560	COG0583	DNA-binding transcription factor activity
ITG10_RS18565	COG2084	Dehydrogenase
ITG10_RS18580	COG0217	transcriptional regulatory protein
ITG10_RS18595	COG3186	Phenylalanine-4-hydroxylase
ITG10_RS18600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG10_RS18615	COG1175	transmembrane transport
ITG10_RS18625	COG3842	ATPase activity
ITG10_RS18630	COG1234	tRNA 3'-trailer cleavage
ITG10_RS18635	COG0483	inositol monophosphate 1-phosphatase activity
ITG10_RS18640	COG1609	Transcriptional regulator
ITG10_RS18645	COG0625	glutathione transferase activity
ITG10_RS18655	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ITG10_RS18675	COG3842	ATPase activity
ITG10_RS18710	COG0765	amino acid transport
ITG10_RS18725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG10_RS18740	COG4221	oxidoreductase activity
ITG10_RS18750	COG2205	protein histidine kinase activity
ITG10_RS18750	COG4999	Histidine kinase
ITG10_RS18750	COG3437	response regulator, receiver
ITG10_RS18750	COG3850	Histidine kinase
ITG10_RS18760	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ITG10_RS18760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG10_RS18775	COG0444	Belongs to the ABC transporter superfamily
ITG10_RS18805	COG2801	Transposase and inactivated derivatives
ITG10_RS18810	COG2963	transposase activity
ITG10_RS18820	COG1444	tRNA N-acetyltransferase activity
ITG10_RS18860	COG0259	pyridoxamine-phosphate oxidase activity
ITG10_RS18880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ITG10_RS18905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG10_RS18945	COG1132	(ABC) transporter
ITG10_RS18970	COG2194	sulfuric ester hydrolase activity
ITG10_RS19000	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ITG10_RS19010	COG4145	pantothenate transmembrane transporter activity
ITG10_RS19015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG10_RS19020	COG0800	Aldolase
ITG10_RS19035	COG2204	response regulator
ITG10_RS19050	COG0579	oxidoreductase
ITG10_RS19070	COG2205	protein histidine kinase activity
ITG10_RS19075	COG0745	RESPONSE REGULATOR receiver
ITG10_RS19095	COG1309	transcriptional regulator
ITG10_RS19100	COG1012	belongs to the aldehyde dehydrogenase family
ITG10_RS19120	COG4175	Glycine betaine
ITG10_RS19120	COG0517	IMP dehydrogenase activity
ITG10_RS19125	COG1846	Transcriptional regulator
ITG10_RS19165	COG0641	radical SAM
ITG10_RS19170	COG1309	transcriptional regulator
ITG10_RS19180	COG0456	acetyltransferase
ITG10_RS19200	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITG10_RS19205	COG0800	Aldolase
ITG10_RS19210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG10_RS19215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG10_RS19215	COG1263	PTS System
ITG10_RS19225	COG2188	Transcriptional regulator
ITG10_RS19235	COG2207	Transcriptional regulator
ITG10_RS19260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG10_RS19275	COG2207	Transcriptional regulator
ITG10_RS19280	COG2814	Major facilitator Superfamily
ITG10_RS19290	COG0604	alcohol dehydrogenase
ITG10_RS19290	COG3321	synthase
ITG10_RS19290	COG1028	Short-chain dehydrogenase reductase Sdr
ITG10_RS19345	COG1609	Transcriptional regulator
ITG10_RS19350	COG0129	dihydroxy-acid dehydratase activity
ITG10_RS19355	COG3265	gluconokinase activity
ITG10_RS19360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG10_RS19360	COG1263	PTS System
ITG10_RS19365	COG2723	6-phospho-beta-galactosidase activity
ITG10_RS19370	COG0800	Aldolase
ITG10_RS19380	COG0300	oxidoreductase activity
ITG10_RS19390	COG0534	Mate efflux family protein
ITG10_RS19395	COG0583	DNA-binding transcription factor activity
ITG10_RS19400	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ITG10_RS19415	COG0346	lactoylglutathione lyase activity
ITG10_RS19430	COG2723	6-phospho-beta-galactosidase activity
ITG10_RS19435	COG1609	Transcriptional regulator
ITG10_RS19440	COG0110	maltose O-acetyltransferase activity
ITG10_RS19445	COG2814	Major facilitator Superfamily
ITG10_RS19450	COG0583	DNA-binding transcription factor activity
ITG10_RS19455	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ITG10_RS19460	COG1301	dicarboxylic acid transport
ITG10_RS19475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ITG10_RS19485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG10_RS19510	COG0583	DNA-binding transcription factor activity
ITG10_RS19520	COG1028	Short-chain dehydrogenase reductase Sdr
ITG10_RS19525	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ITG10_RS19530	COG1349	DNA-binding transcription factor activity
ITG10_RS19535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ITG10_RS19540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ITG10_RS19550	COG0583	DNA-binding transcription factor activity
ITG10_RS19555	COG0798	PFAM Bile acid sodium symporter
ITG10_RS19570	COG1309	transcriptional regulator
ITG10_RS19575	COG0561	phosphatase activity
ITG10_RS19590	COG3214	Protein conserved in bacteria
ITG10_RS19595	COG0583	DNA-binding transcription factor activity
ITG10_RS19660	COG0561	phosphatase activity
ITG10_RS19665	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ITG10_RS19670	COG3623	hexulose-6-phosphate isomerase
ITG10_RS19680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG10_RS19685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ITG10_RS19705	COG3623	hexulose-6-phosphate isomerase
ITG10_RS19710	COG1414	Transcriptional regulator
ITG10_RS19715	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ITG10_RS19730	COG0561	phosphatase activity
ITG10_RS19740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG10_RS19745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG10_RS19750	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG10_RS19760	COG1929	Belongs to the glycerate kinase type-1 family
ITG10_RS19765	COG0753	catalase activity
ITG10_RS19770	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG10_RS19775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG10_RS19780	COG3615	Tellurite resistance protein tehB
ITG10_RS19785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG10_RS19790	COG0204	Acyl-transferase
ITG10_RS19810	COG4580	involved in the transport of maltose and maltodextrins
ITG10_RS19850	COG3258	Cytochrome c
ITG10_RS19890	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ITG10_RS19895	COG1162	GTPase activity
ITG10_RS19905	COG1999	signal sequence binding
ITG10_RS19920	COG2909	trisaccharide binding
ITG10_RS19925	COG0058	SHG alpha-glucan phosphorylase activity
ITG10_RS19930	COG1640	4-alpha-glucanotransferase
ITG10_RS19935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ITG10_RS19950	COG1122	ATPase activity
ITG10_RS19955	COG4720	Psort location CytoplasmicMembrane, score
ITG10_RS19960	COG1566	PFAM secretion protein HlyD family protein
ITG10_RS19990	COG0813	purine-nucleoside phosphorylase activity
ITG10_RS19995	COG1376	ErfK ybiS ycfS ynhG family protein
ITG10_RS19995	COG1388	LysM domain
ITG10_RS20005	COG0513	Belongs to the DEAD box helicase family
ITG10_RS20010	COG3240	lipase activity
ITG10_RS20015	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ITG10_RS20030	COG4771	TonB-dependent receptor
ITG10_RS20065	COG0573	inorganic phosphate transmembrane transporter activity
ITG10_RS20070	COG0581	inorganic phosphate transmembrane transporter activity
ITG10_RS20075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG10_RS20095	COG2304	oxidoreductase activity
ITG10_RS20100	COG2304	oxidoreductase activity
ITG10_RS20115	COG0714	Associated with various cellular activities
ITG10_RS20120	COG0840	transmembrane signaling receptor activity
ITG10_RS20130	COG3842	ATPase activity
ITG10_RS20140	COG1175	transmembrane transport
ITG10_RS20145	COG3833	ABC-type maltose transport systems, permease component
ITG10_RS20160	COG4166	transmembrane transport
ITG10_RS20190	COG0577	efflux transmembrane transporter activity
ITG10_RS20195	COG1136	(ABC) transporter
ITG10_RS20210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG10_RS20215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG10_RS20235	COG3706	GGDEF domain
ITG10_RS20255	COG1028	Short-chain dehydrogenase reductase Sdr
ITG10_RS20275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG10_RS20280	COG1904	glucuronate isomerase
ITG10_RS20300	COG4934	collagen metabolic process
ITG10_RS20330	COG1012	belongs to the aldehyde dehydrogenase family
ITG10_RS20335	COG1414	Transcriptional regulator
ITG10_RS20340	COG0280	phosphate acetyltransferase
ITG10_RS20345	COG0730	response to heat
ITG10_RS20375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG10_RS20380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG10_RS20385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG10_RS20390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG10_RS20390	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG10_RS20405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG10_RS20430	COG0418	dihydroorotase activity
ITG10_RS20440	COG0633	Ferredoxin
ITG10_RS20440	COG3217	Mosc domain protein beta barrel domain protein
ITG10_RS20445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ITG10_RS20500	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ITG10_RS20505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG10_RS20515	COG0848	biopolymer transport protein
ITG10_RS20520	COG0811	peptide transport
ITG10_RS20525	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ITG10_RS20535	COG3721	Heme iron utilization protein
ITG10_RS20540	COG0748	coenzyme F420 binding
ITG10_RS20545	COG2096	Adenosyltransferase
ITG10_RS20550	COG0835	chemotaxis
ITG10_RS20550	COG0784	Response regulator, receiver
ITG10_RS20555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG10_RS20560	COG0366	Alpha amylase catalytic
ITG10_RS20570	COG3314	Sporulation integral membrane protein YlbJ
ITG10_RS20595	COG0739	heme binding
ITG10_RS20600	COG5001	Diguanylate cyclase
ITG10_RS20605	COG0583	DNA-binding transcription factor activity
ITG10_RS20610	COG2814	Major facilitator Superfamily
ITG10_RS20615	COG0583	DNA-binding transcription factor activity
ITG10_RS20620	COG2814	Major facilitator Superfamily
ITG10_RS20635	COG0697	spore germination
ITG10_RS20655	COG3118	belongs to the thioredoxin family
ITG10_RS20660	COG4232	protein-disulfide reductase activity
ITG10_RS20675	COG0668	transmembrane transport
ITG10_RS20685	COG2197	response regulator
ITG10_RS20720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG10_RS20725	COG1538	Outer membrane efflux protein
ITG10_RS20745	COG4989	oxidoreductase activity
ITG10_RS20755	COG0513	Belongs to the DEAD box helicase family
ITG10_RS20770	COG2176	DNA-directed DNA polymerase activity
ITG10_RS20780	COG0513	Belongs to the DEAD box helicase family
ITG10_RS20800	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ITG10_RS20805	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ITG10_RS20810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG10_RS20815	COG0667	Aldo Keto reductase
ITG10_RS20830	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG10_RS20880	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ITG10_RS20885	COG0513	Belongs to the DEAD box helicase family
ITG10_RS20895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITG10_RS20925	COG0604	alcohol dehydrogenase
ITG10_RS20955	COG0697	spore germination
ITG10_RS20970	COG0366	Alpha amylase catalytic
ITG10_RS20975	COG0583	DNA-binding transcription factor activity
ITG10_RS20980	COG0534	Mate efflux family protein
ITG10_RS20985	COG3678	ATP-independent chaperone mediated protein folding
ITG10_RS21015	COG0516	GMP reductase activity
ITG10_RS21145	COG0697	spore germination
ITG10_RS21150	COG0351	phosphomethylpyrimidine kinase
ITG10_RS21155	COG1116	anion transmembrane transporter activity
ITG10_RS21160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ITG10_RS21165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ITG10_RS21170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ITG10_RS21175	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ITG10_RS21180	COG2801	Transposase and inactivated derivatives
ITG10_RS21195	COG0352	thiamine-phosphate diphosphorylase activity
ITG10_RS21205	COG0583	DNA-binding transcription factor activity
ITG10_RS21230	COG0402	S-adenosylhomocysteine deaminase activity
ITG10_RS21250	COG3706	GGDEF domain
ITG10_RS21260	COG1566	PFAM secretion protein HlyD family protein
ITG10_RS21270	COG0628	permease
ITG10_RS21305	COG4607	ABC-type enterochelin transport system periplasmic component
ITG10_RS21310	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG10_RS21315	COG4605	iron ion homeostasis
ITG10_RS21320	COG4604	ABC transporter, ATP-binding protein
ITG10_RS21325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG10_RS21335	COG0573	inorganic phosphate transmembrane transporter activity
ITG10_RS21340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ITG10_RS21345	COG3437	response regulator, receiver
ITG10_RS21350	COG0784	Response regulator, receiver
ITG10_RS21350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG10_RS21350	COG2198	Histidine kinase
ITG10_RS21350	COG2205	protein histidine kinase activity
ITG10_RS21355	COG0583	DNA-binding transcription factor activity
ITG10_RS21360	COG2814	Major facilitator Superfamily
ITG10_RS21380	COG1522	sequence-specific DNA binding
ITG10_RS21385	COG0840	transmembrane signaling receptor activity
ITG10_RS21400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG10_RS21420	COG2897	thiosulfate sulfurtransferase activity
ITG10_RS21450	COG0302	gtp cyclohydrolase
ITG10_RS21460	COG4681	YaeQ
ITG10_RS21465	COG1278	Cold shock
ITG10_RS21470	COG2133	pyrroloquinoline quinone binding
ITG10_RS21480	COG1120	ATPase activity
ITG10_RS21510	COG1024	Enoyl-CoA hydratase
ITG10_RS21530	COG2985	domain, Protein
ITG10_RS21540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG10_RS21545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG10_RS21565	COG3710	Transcriptional regulator
ITG10_RS21575	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG10_RS21575	COG1902	pentaerythritol trinitrate reductase activity
ITG10_RS21600	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG10_RS21630	COG2824	Alkylphosphonate utilization operon protein PhnA
ITG10_RS21670	COG1280	lysine exporter protein (LysE YggA)
ITG10_RS21695	COG0765	amino acid transport
ITG10_RS21705	COG0765	amino acid transport
ITG10_RS21710	COG1126	abc transporter atp-binding protein
ITG10_RS21715	COG1979	alcohol dehydrogenase
ITG10_RS21720	COG2207	Transcriptional regulator
ITG10_RS21755	COG3059	membrane
ITG10_RS21775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG10_RS21785	COG3706	GGDEF domain
ITG10_RS21800	COG1686	Belongs to the peptidase S11 family
ITG10_RS21810	COG0583	DNA-binding transcription factor activity
ITG10_RS21820	COG0564	pseudouridine synthase activity
ITG10_RS21830	COG2130	NADP-dependent
ITG10_RS21835	COG1309	transcriptional regulator
ITG10_RS21840	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG10_RS21860	COG3604	Transcriptional regulator
ITG10_RS21865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG10_RS21865	COG1017	nitric oxide dioxygenase activity
ITG10_RS21870	COG1609	Transcriptional regulator
ITG10_RS21880	COG1175	transmembrane transport
ITG10_RS21885	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ITG10_RS21895	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ITG10_RS21905	COG0038	chloride channel
ITG10_RS21910	COG0523	cobalamin synthesis protein
ITG10_RS21915	COG0513	Belongs to the DEAD box helicase family
ITG10_RS21945	COG0745	RESPONSE REGULATOR receiver
ITG10_RS22005	COG0183	Belongs to the thiolase family
ITG10_RS22015	COG3243	poly(R)-hydroxyalkanoic acid synthase
ITG10_RS22040	COG0243	molybdopterin cofactor binding
ITG10_RS22050	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG10_RS22050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG10_RS22055	COG3850	Histidine kinase
ITG10_RS22060	COG2197	response regulator
ITG10_RS22065	COG3069	C4-dicarboxylate transmembrane transporter activity
ITG10_RS22085	COG2067	long-chain fatty acid transport protein
ITG10_RS22090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG10_RS22095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG10_RS22120	COG2188	Transcriptional regulator
ITG10_RS22125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG10_RS22125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG10_RS22125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG10_RS22130	COG0383	alpha-mannosidase activity
ITG10_RS22135	COG1929	Belongs to the glycerate kinase type-1 family
ITG10_RS22165	COG3706	GGDEF domain
ITG10_RS22265	COG3706	GGDEF domain
ITG10_RS22275	COG2197	response regulator
ITG10_RS22295	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ITG10_RS22300	COG0494	nUDIX hydrolase
ITG10_RS22305	COG0714	Associated with various cellular activities
ITG10_RS22310	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ITG10_RS22335	COG0840	transmembrane signaling receptor activity
ITG10_RS22375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG10_RS22385	COG2116	formate transmembrane transporter activity
ITG10_RS22390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ITG10_RS22390	COG1648	precorrin-2 dehydrogenase activity
ITG10_RS22405	COG0745	RESPONSE REGULATOR receiver
ITG10_RS22410	COG2205	protein histidine kinase activity
ITG10_RS22415	COG1301	dicarboxylic acid transport
ITG10_RS22420	COG4774	siderophore transport
ITG10_RS22430	COG0811	peptide transport
ITG10_RS22435	COG0811	peptide transport
ITG10_RS22440	COG0848	biopolymer transport protein
ITG10_RS22485	COG0803	Belongs to the bacterial solute-binding protein 9 family
ITG10_RS22490	COG1121	(ABC) transporter
ITG10_RS22495	COG1321	iron dependent repressor
ITG10_RS22495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG10_RS22520	COG0534	Mate efflux family protein
ITG10_RS22550	COG0318	PFAM AMP-dependent synthetase and ligase
ITG10_RS22560	COG3118	belongs to the thioredoxin family
ITG10_RS22565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG10_RS22585	COG2391	methyltransferase activity
ITG10_RS22595	COG1328	CTP reductase activity
ITG10_RS22600	COG0602	queuosine metabolic process
ITG10_RS22620	COG4067	protein conserved in archaea
ITG10_RS22620	COG0189	ligase activity
ITG10_RS22625	COG0488	(ABC) transporter
ITG10_RS22630	COG2963	transposase activity
ITG10_RS22635	COG2801	Transposase and inactivated derivatives
ITG10_RS22640	COG0840	transmembrane signaling receptor activity
ITG10_RS22670	COG0725	ABC transporter, periplasmic molybdate-binding protein
ITG10_RS22675	COG4149	molybdate abc transporter
ITG10_RS22680	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ITG10_RS22690	COG2203	Gaf domain
ITG10_RS22690	COG3706	GGDEF domain
ITG10_RS22690	COG4251	negative regulation of phosphorylation
ITG10_RS22690	COG5001	Diguanylate cyclase
ITG10_RS22700	COG3706	GGDEF domain
ITG10_RS22715	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ITG10_RS22720	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ITG10_RS22745	COG3140	Belongs to the UPF0181 family
ITG10_RS22750	COG3706	GGDEF domain
ITG10_RS22760	COG0023	Translation Initiation Factor
ITG10_RS22775	COG1181	Belongs to the D-alanine--D-alanine ligase family
ITG10_RS22780	COG3266	domain, Protein
ITG10_RS22785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG10_RS22785	COG1042	CoA-binding domain protein
ITG10_RS22785	COG0045	succinate-CoA ligase (ADP-forming) activity
ITG10_RS22790	COG0583	DNA-binding transcription factor activity
ITG10_RS22795	COG1629	transport
ITG10_RS22795	COG4771	TonB-dependent receptor
ITG10_RS22825	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ITG10_RS22830	COG1984	allophanate hydrolase subunit 2
ITG10_RS22840	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ITG10_RS22845	COG4181	ATPase activity
ITG10_RS22855	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG10_RS22860	COG5001	Diguanylate cyclase
ITG10_RS22860	COG1716	ATPase activity
ITG10_RS22870	COG0768	penicillin binding
ITG10_RS22900	COG4533	DNA binding
ITG10_RS22910	COG2050	protein possibly involved in aromatic compounds catabolism
ITG10_RS22915	COG0501	Belongs to the peptidase M48B family
ITG10_RS22925	COG2067	long-chain fatty acid transport protein
ITG10_RS22930	COG2267	carboxylic ester hydrolase activity
ITG10_RS22945	COG0583	DNA-binding transcription factor activity
ITG10_RS22960	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ITG10_RS23000	COG1566	PFAM secretion protein HlyD family protein
ITG10_RS23020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG10_RS23030	COG0729	surface antigen
ITG10_RS23035	COG0513	Belongs to the DEAD box helicase family
ITG10_RS23050	COG0861	Integral membrane protein TerC family
ITG10_RS23055	COG0737	Belongs to the 5'-nucleotidase family
ITG10_RS23060	COG3593	DNA synthesis involved in DNA repair
ITG10_RS23070	COG0583	DNA-binding transcription factor activity
ITG10_RS23075	COG2116	formate transmembrane transporter activity
ITG10_RS23080	COG2353	YceI-like domain
ITG10_RS23085	COG3038	cytochrome b561
ITG10_RS23100	COG2200	EAL domain
ITG10_RS23130	COG0513	Belongs to the DEAD box helicase family
ITG10_RS23135	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ITG10_RS23140	COG0814	amino acid
ITG10_RS23150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG10_RS23155	COG3437	response regulator, receiver
ITG10_RS23155	COG0784	Response regulator, receiver
ITG10_RS23170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG10_RS23175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ITG10_RS23185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG10_RS23230	COG0509	glycine decarboxylation via glycine cleavage system
ITG10_RS23250	COG0534	Mate efflux family protein
ITG10_RS23270	COG1280	lysine exporter protein (LysE YggA)
ITG10_RS23290	COG3227	Zinc metalloprotease (Elastase)
ITG10_RS23310	COG2807	transmembrane transport
ITG10_RS23320	COG1881	PFAM PEBP family protein
ITG10_RS23370	COG0840	transmembrane signaling receptor activity
ITG10_RS23420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG10_RS23425	COG0784	Response regulator, receiver
ITG10_RS23425	COG2205	protein histidine kinase activity
ITG10_RS23430	COG1538	Outer membrane efflux protein
ITG10_RS23450	COG5002	protein histidine kinase activity
ITG10_RS23450	COG2205	protein histidine kinase activity
ITG10_RS23450	COG0784	Response regulator, receiver
ITG10_RS23485	COG0840	transmembrane signaling receptor activity
ITG10_RS23490	COG0405	Gamma-glutamyltransferase
ITG10_RS23500	COG0641	radical SAM
ITG10_RS23515	COG1597	lipid kinase activity
ITG10_RS23520	COG0583	DNA-binding transcription factor activity
ITG10_RS23550	COG0714	Associated with various cellular activities
ITG10_RS23565	COG3119	arylsulfatase activity
ITG10_RS23590	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG10_RS23610	COG2197	response regulator
ITG10_RS23615	COG0456	acetyltransferase
ITG10_RS23625	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ITG10_RS23660	COG0384	phenazine biosynthesis protein PhzF
ITG10_RS23670	COG5001	Diguanylate cyclase
ITG10_RS23670	COG3300	MHYT domain
ITG10_RS23690	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG10_RS23730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG10_RS23740	COG1012	belongs to the aldehyde dehydrogenase family
ITG10_RS23750	COG0583	DNA-binding transcription factor activity
ITG10_RS23760	COG0356	it plays a direct role in the translocation of protons across the membrane
ITG10_RS23775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ITG10_RS23785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG10_RS23795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG10_RS23805	COG0583	DNA-binding transcription factor activity
ITG10_RS23825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ITG10_RS23835	COG1609	Transcriptional regulator
ITG10_RS23840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG10_RS23850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG10_RS23850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG10_RS23865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG10_RS23875	COG0642	Histidine kinase
ITG10_RS23880	COG0745	RESPONSE REGULATOR receiver
ITG10_RS23895	COG4608	Belongs to the ABC transporter superfamily
ITG10_RS23900	COG0444	Belongs to the ABC transporter superfamily
ITG10_RS23910	COG4239	(ABC) transporter, permease
ITG10_RS23915	COG4174	ABC transporter (Permease)
ITG10_RS23920	COG4172	Belongs to the ABC transporter superfamily
ITG10_RS23925	COG4239	(ABC) transporter, permease
ITG10_RS23930	COG4174	ABC transporter (Permease)
ITG10_RS23935	COG4166	transmembrane transport
ITG10_RS23960	COG1869	D-ribose catabolic process
ITG10_RS23965	COG1129	ABC transporter
ITG10_RS23970	COG1172	Belongs to the binding-protein-dependent transport system permease family
ITG10_RS23975	COG1879	ABC-type sugar transport system periplasmic component
ITG10_RS23980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG10_RS23985	COG1609	Transcriptional regulator
ITG10_RS24005	COG0784	Response regulator, receiver
ITG10_RS24005	COG2205	protein histidine kinase activity
ITG10_RS24040	COG4974	Belongs to the 'phage' integrase family
ITG10_RS24055	COG2026	Addiction module toxin, RelE StbE family
ITG10_RS24065	COG0243	molybdopterin cofactor binding
ITG10_RS24070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG10_RS24080	COG2223	nitrite transmembrane transporter activity
ITG10_RS24085	COG0515	serine threonine protein kinase
ITG10_RS24085	COG2815	serine threonine protein kinase
ITG10_RS24090	COG1609	Transcriptional regulator
ITG10_RS24095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG10_RS24095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG10_RS24100	COG1105	Belongs to the carbohydrate kinase PfkB family
ITG10_RS24105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG10_RS24105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG10_RS24105	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ITG10_RS24115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG10_RS24140	COG0745	RESPONSE REGULATOR receiver
ITG10_RS24145	COG2205	protein histidine kinase activity
ITG10_RS24160	COG1252	NADH dehydrogenase
ITG10_RS24165	COG0625	glutathione transferase activity
ITG10_RS24215	COG2205	protein histidine kinase activity
ITG10_RS24215	COG2198	Histidine kinase
ITG10_RS24215	COG0784	Response regulator, receiver
ITG10_RS24220	COG1879	ABC-type sugar transport system periplasmic component
ITG10_RS24225	COG1803	Methylglyoxal synthase
ITG10_RS24230	COG2801	Transposase and inactivated derivatives
ITG10_RS24235	COG2801	Transposase and inactivated derivatives
ITG10_RS24240	COG2963	transposase activity
ITG10_RS24250	COG0210	DNA helicase
ITG10_RS24255	COG1289	transmembrane transporter activity
ITG10_RS24275	COG0583	DNA-binding transcription factor activity
ITG10_RS24280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG10_RS24285	COG1328	CTP reductase activity
ITG10_RS24315	COG1011	Hydrolase
ITG10_RS24325	COG1454	alcohol dehydrogenase
ITG10_RS24345	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG10_RS24375	COG1063	alcohol dehydrogenase
ITG10_RS24380	COG0156	8-amino-7-oxononanoate synthase activity
ITG10_RS24385	COG2200	EAL domain
ITG10_RS24395	COG2211	Major facilitator Superfamily
ITG10_RS24400	COG1136	(ABC) transporter
ITG10_RS24400	COG0577	efflux transmembrane transporter activity
ITG10_RS24405	COG0577	efflux transmembrane transporter activity
ITG10_RS24405	COG1136	(ABC) transporter
ITG10_RS24420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG10_RS24430	COG0346	lactoylglutathione lyase activity
ITG10_RS24450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ITG10_RS24455	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG10_RS24470	COG0393	Putative heavy-metal-binding
ITG10_RS24475	COG0739	heme binding
ITG10_RS24505	COG1132	(ABC) transporter
ITG10_RS24510	COG1132	(ABC) transporter
ITG10_RS24525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ITG10_RS24545	COG1760	l-serine dehydratase
ITG10_RS24550	COG3104	oligopeptide transport
ITG10_RS24560	COG2375	cellular response to nickel ion
ITG10_RS24580	COG3842	ATPase activity
ITG10_RS24590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG10_RS24595	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG10_RS24605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ITG10_RS24620	COG1765	OsmC-like protein
ITG10_RS24625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG10_RS24625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG10_RS24640	COG2801	Transposase and inactivated derivatives
ITG10_RS24645	COG2801	Transposase and inactivated derivatives
ITG10_RS24650	COG2963	transposase activity
ITG10_RS24655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG10_RS24660	COG0569	domain protein
ITG10_RS24665	COG0668	transmembrane transport
ITG10_RS24670	COG0662	Cupin 2, conserved barrel domain protein
ITG10_RS24670	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ITG10_RS24685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG10_RS24695	COG3344	reverse transcriptase
ITG10_RS24700	COG3530	Putative quorum-sensing-regulated virulence factor
ITG10_RS24720	COG0109	protoheme IX farnesyltransferase activity
ITG10_RS24725	COG1612	heme a metabolic process
ITG10_RS24745	COG1845	cytochrome c oxidase, subunit III
ITG10_RS24755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITG10_RS24760	COG1565	acr, cog1565
ITG10_RS24760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ITG10_RS24765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG10_RS24775	COG1280	lysine exporter protein (LysE YggA)
ITG10_RS24780	COG0179	Fumarylacetoacetate (FAA) hydrolase
ITG10_RS24790	COG0443	Heat shock 70 kDa protein
ITG10_RS24820	COG2827	Endonuclease containing a URI domain
ITG10_RS24825	COG3132	Protein of unknown function, DUF480
ITG10_RS24835	COG2926	Belongs to the UPF0265 family
ITG10_RS24860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG10_RS24865	COG1151	hydroxylamine reductase activity
ITG10_RS24880	COG1280	lysine exporter protein (LysE YggA)
ITG10_RS24895	COG0531	amino acid
ITG10_RS24910	COG4413	Urea transporter
ITG10_RS24930	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ITG10_RS24935	COG0402	S-adenosylhomocysteine deaminase activity
ITG10_RS24940	COG1278	Cold shock
ITG10_RS24945	COG3706	GGDEF domain
ITG10_RS24960	COG0513	Belongs to the DEAD box helicase family
ITG10_RS24975	COG4106	trans-aconitate 2-methyltransferase activity
ITG10_RS24980	COG2205	protein histidine kinase activity
ITG10_RS24985	COG0745	RESPONSE REGULATOR receiver
ITG10_RS24990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG10_RS25010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG10_RS25025	COG3037	sugar-specific permease SgaT UlaA
ITG10_RS25030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG10_RS25035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG10_RS25040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG10_RS25045	COG2205	protein histidine kinase activity
ITG10_RS25050	COG0745	RESPONSE REGULATOR receiver
ITG10_RS25060	COG5001	Diguanylate cyclase
ITG10_RS25075	COG2200	EAL domain
ITG10_RS25085	COG2186	Transcriptional regulator
ITG10_RS25090	COG1131	(ABC) transporter
ITG10_RS25115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG10_RS25115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG10_RS25125	COG0564	pseudouridine synthase activity
ITG10_RS25135	COG2814	Major facilitator Superfamily
ITG10_RS25155	COG4977	sequence-specific DNA binding
ITG10_RS25190	COG4533	DNA binding
ITG10_RS25195	COG0189	ligase activity
ITG10_RS25200	COG4067	protein conserved in archaea
ITG10_RS25200	COG0189	ligase activity
ITG10_RS25220	COG1175	transmembrane transport
ITG10_RS25225	COG0395	ABC-type sugar transport system, permease component
ITG10_RS25230	COG3842	ATPase activity
ITG10_RS25235	COG0584	glycerophosphoryl diester phosphodiesterase
ITG10_RS25255	COG0673	inositol 2-dehydrogenase activity
ITG10_RS25265	COG2999	glutathione oxidoreductase activity
ITG10_RS25270	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ITG10_RS25310	COG0534	Mate efflux family protein
ITG10_RS25315	COG0110	maltose O-acetyltransferase activity
ITG10_RS25320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ITG10_RS25330	COG3454	Phosphonate metabolism
ITG10_RS25335	COG4778	phosphonate C-P lyase system protein PhnL
ITG10_RS25340	COG4107	phosphonate C-P lyase system protein PhnK
ITG10_RS25345	COG3627	carbon phosphorus lyase activity
ITG10_RS25350	COG3626	phosphonate metabolism
ITG10_RS25355	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ITG10_RS25360	COG3624	Phosphonate C-P lyase system protein PhnG
ITG10_RS25365	COG2188	Transcriptional regulator
ITG10_RS25370	COG3639	organic phosphonate transmembrane transporter activity
ITG10_RS25375	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ITG10_RS25405	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG10_RS25505	COG0745	RESPONSE REGULATOR receiver
ITG10_RS25565	COG0582	viral genome integration into host DNA
ITG10_RS25625	COG1901	pseudouridine methyltransferase
ITG10_RS25645	COG1595	DNA-templated transcription, initiation
ITG10_RS25650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITG10_RS25680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG10_RS25695	COG1028	Short-chain dehydrogenase reductase Sdr
ITG10_RS25700	COG1733	regulation of RNA biosynthetic process
ITG10_RS25705	COG0583	DNA-binding transcription factor activity
ITG10_RS25710	COG4221	oxidoreductase activity
ITG10_RS25720	COG3047	cAMP biosynthetic process
ITG10_RS25725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG10_RS25730	COG1288	antiporter activity
ITG10_RS25775	COG3639	organic phosphonate transmembrane transporter activity
ITG10_RS25780	COG3639	organic phosphonate transmembrane transporter activity
ITG10_RS25785	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ITG10_RS25810	COG4948	Mandelate Racemase Muconate Lactonizing
ITG10_RS25820	COG0583	DNA-binding transcription factor activity
ITG10_RS25855	COG0583	DNA-binding transcription factor activity
ITG10_RS25875	COG2801	Transposase and inactivated derivatives
ITG10_RS25880	COG2801	Transposase and inactivated derivatives
ITG10_RS25915	COG1757	Na H antiporter
ITG10_RS25920	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITG10_RS25945	COG2814	Major facilitator Superfamily
ITG10_RS25950	COG0814	amino acid
ITG10_RS25955	COG0840	transmembrane signaling receptor activity
ITG10_RS25965	COG0702	epimerase
ITG10_RS25975	COG3226	Transcriptional regulator
ITG10_RS25985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG10_RS25990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG10_RS26000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG10_RS26005	COG2207	Transcriptional regulator
ITG10_RS26010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG10_RS26010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG10_RS26010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG10_RS26025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG10_RS26035	COG0765	amino acid transport
ITG10_RS26040	COG3842	ATPase activity
ITG10_RS26045	COG0546	phosphoglycolate phosphatase activity
ITG10_RS26070	COG0583	DNA-binding transcription factor activity
ITG10_RS26075	COG4166	transmembrane transport
ITG10_RS26105	COG3547	Transposase (IS116 IS110 IS902 family)
ITG10_RS26125	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ITG10_RS26135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ITG10_RS26150	COG1012	belongs to the aldehyde dehydrogenase family
ITG10_RS26155	COG3284	Transcriptional regulator
ITG10_RS26160	COG0415	Belongs to the DNA photolyase family
ITG10_RS26170	COG0625	glutathione transferase activity
ITG10_RS26175	COG3655	Transcriptional regulator
ITG10_RS26190	COG1621	beta-fructofuranosidase activity
ITG10_RS26195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG10_RS26200	COG1263	PTS System
ITG10_RS26200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG10_RS26240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG10_RS26245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG10_RS26250	COG1418	mRNA catabolic process
ITG10_RS26265	COG2186	Transcriptional regulator