locus-tag	class	description
CCZ37_RS00005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCZ37_RS00015	COG0592	DNA-directed DNA polymerase activity
CCZ37_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CCZ37_RS00025	COG0187	DNA topoisomerase II activity
CCZ37_RS00035	COG3977	Valine--pyruvate aminotransferase
CCZ37_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
CCZ37_RS00050	COG2119	membrane
CCZ37_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
CCZ37_RS00075	COG0604	alcohol dehydrogenase
CCZ37_RS00090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CCZ37_RS00095	COG3978	acetolactate synthase activity
CCZ37_RS00105	COG0606	chelatase, subunit chli
CCZ37_RS00115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CCZ37_RS00120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CCZ37_RS00135	COG3084	Protein conserved in bacteria
CCZ37_RS00145	COG1272	protein, Hemolysin III
CCZ37_RS00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CCZ37_RS00155	COG0569	domain protein
CCZ37_RS00160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CCZ37_RS00160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CCZ37_RS00165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CCZ37_RS00170	COG0242	peptide deformylase activity
CCZ37_RS00175	COG1652	LysM domain
CCZ37_RS00180	COG0758	DNA mediated transformation
CCZ37_RS00185	COG2922	Belongs to the Smg family
CCZ37_RS00190	COG0551	DNA topoisomerase type I activity
CCZ37_RS00195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CCZ37_RS00200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CCZ37_RS00205	COG0009	L-threonylcarbamoyladenylate synthase
CCZ37_RS00210	COG0408	coproporphyrinogen oxidase activity
CCZ37_RS00215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CCZ37_RS00225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CCZ37_RS00300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CCZ37_RS00305	COG5001	Diguanylate cyclase
CCZ37_RS00305	COG3300	MHYT domain
CCZ37_RS00315	COG3852	Histidine kinase
CCZ37_RS00325	COG0174	glutamine synthetase
CCZ37_RS00330	COG1217	gtp-binding protein TYPA
CCZ37_RS00335	COG1295	ribonuclease BN
CCZ37_RS00340	COG1490	D-aminoacyl-tRNA deacylase activity
CCZ37_RS00345	COG0456	acetyltransferase
CCZ37_RS00355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CCZ37_RS00360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CCZ37_RS00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CCZ37_RS00370	COG3031	protein transport across the cell outer membrane
CCZ37_RS00380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CCZ37_RS00385	COG1459	type II secretion system
CCZ37_RS00390	COG2165	general secretion pathway protein
CCZ37_RS00395	COG2165	general secretion pathway protein
CCZ37_RS00400	COG2165	general secretion pathway protein
CCZ37_RS00405	COG4795	General secretion pathway protein
CCZ37_RS00410	COG3156	type II secretion system protein K
CCZ37_RS00415	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CCZ37_RS00420	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CCZ37_RS00430	COG1218	3'(2'),5'-bisphosphate nucleotidase
CCZ37_RS00435	COG0494	nUDIX hydrolase
CCZ37_RS00440	COG0316	Belongs to the HesB IscA family
CCZ37_RS00440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CCZ37_RS00445	COG1040	competence protein
CCZ37_RS00450	COG0596	Alpha beta hydrolase
CCZ37_RS00460	COG2183	response to ionizing radiation
CCZ37_RS00465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CCZ37_RS00495	COG2233	PERMEase
CCZ37_RS00500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CCZ37_RS00505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CCZ37_RS00515	COG0194	GDP metabolic process
CCZ37_RS00520	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CCZ37_RS00525	COG0248	Ppx GppA phosphatase
CCZ37_RS00535	COG3118	belongs to the thioredoxin family
CCZ37_RS00550	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CCZ37_RS00605	COG3071	HemY protein
CCZ37_RS00610	COG2959	enzyme of heme biosynthesis
CCZ37_RS00615	COG1587	Uroporphyrinogen-III synthase
CCZ37_RS00640	COG0019	diaminopimelate decarboxylase activity
CCZ37_RS00645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CCZ37_RS00655	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CCZ37_RS00660	COG1011	Hydrolase
CCZ37_RS00665	COG3148	PFAM DTW domain containing protein
CCZ37_RS00675	COG0561	phosphatase activity
CCZ37_RS00680	COG2267	carboxylic ester hydrolase activity
CCZ37_RS00685	COG1280	lysine exporter protein (LysE YggA)
CCZ37_RS00690	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CCZ37_RS00695	COG0783	Belongs to the Dps family
CCZ37_RS00730	COG2095	MarC family integral membrane protein
CCZ37_RS00740	COG0742	ribosomal rna small subunit methyltransferase
CCZ37_RS00745	COG0552	protein localization to endoplasmic reticulum
CCZ37_RS00750	COG2884	Cell division ATP-binding protein ftsE
CCZ37_RS00755	COG2177	Part of the ABC transporter FtsEX involved in
CCZ37_RS00760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CCZ37_RS00770	COG0705	Rhomboid family
CCZ37_RS00775	COG1580	Controls the rotational direction of flagella during chemotaxis
CCZ37_RS00780	COG3161	chorismate lyase activity
CCZ37_RS00790	COG2937	Belongs to the GPAT DAPAT family
CCZ37_RS00795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CCZ37_RS00805	COG0534	Mate efflux family protein
CCZ37_RS00810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCZ37_RS00850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CCZ37_RS00860	COG1461	Dihydroxyacetone kinase
CCZ37_RS00865	COG2376	Dihydroxyacetone kinase
CCZ37_RS00880	COG2223	nitrite transmembrane transporter activity
CCZ37_RS00920	COG4206	TonB-dependent receptor
CCZ37_RS00925	COG1404	Belongs to the peptidase S8 family
CCZ37_RS00930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CCZ37_RS00970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CCZ37_RS00980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CCZ37_RS00985	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CCZ37_RS00985	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CCZ37_RS00990	COG1072	(Pantothenic acid kinase))
CCZ37_RS01015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CCZ37_RS01020	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CCZ37_RS01025	COG0250	Participates in transcription elongation, termination and antitermination
CCZ37_RS01040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CCZ37_RS01045	COG0222	ribosome binding
CCZ37_RS01050	COG0085	RNA polymerase activity
CCZ37_RS01055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CCZ37_RS01060	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CCZ37_RS01065	COG2816	NAD+ diphosphatase activity
CCZ37_RS01070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CCZ37_RS01085	COG4942	peptidase
CCZ37_RS01090	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CCZ37_RS01100	COG0490	domain, Protein
CCZ37_RS01100	COG0471	metal ion transport
CCZ37_RS01110	COG1162	GTPase activity
CCZ37_RS01115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CCZ37_RS01160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CCZ37_RS01165	COG0802	atpase or kinase
CCZ37_RS01170	COG0860	N-Acetylmuramoyl-L-alanine amidase
CCZ37_RS01175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CCZ37_RS01180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CCZ37_RS01190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CCZ37_RS01195	COG0330	HflC and HflK could
CCZ37_RS01200	COG0330	HflC and HflK could
CCZ37_RS01205	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CCZ37_RS01220	COG0545	Peptidyl-prolyl cis-trans isomerase
CCZ37_RS01225	COG2964	Protein conserved in bacteria
CCZ37_RS01230	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CCZ37_RS01235	COG2923	Belongs to the DsrF TusC family
CCZ37_RS01250	COG0049	tRNA binding
CCZ37_RS01255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CCZ37_RS01260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CCZ37_RS01265	COG0360	Binds together with S18 to 16S ribosomal RNA
CCZ37_RS01270	COG2965	DNA replication, synthesis of RNA primer
CCZ37_RS01280	COG0359	binds to the 23S rRNA
CCZ37_RS01295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CCZ37_RS01300	COG0166	Belongs to the GPI family
CCZ37_RS01310	COG0735	belongs to the Fur family
CCZ37_RS01315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CCZ37_RS01335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CCZ37_RS01345	COG0175	sulfate reduction
CCZ37_RS01430	COG1410	methionine synthase
CCZ37_RS01430	COG0646	methionine synthase
CCZ37_RS01435	COG0527	aspartate kinase activity
CCZ37_RS01440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CCZ37_RS01455	COG2239	Acts as a magnesium transporter
CCZ37_RS01465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CCZ37_RS01480	COG0629	single-stranded DNA binding
CCZ37_RS01485	COG2199	diguanylate cyclase activity
CCZ37_RS01485	COG2200	EAL domain
CCZ37_RS01510	COG3409	Peptidoglycan-binding domain 1 protein
CCZ37_RS01510	COG3267	Type II secretory pathway component ExeA
CCZ37_RS01520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CCZ37_RS01525	COG1459	type II secretion system
CCZ37_RS01535	COG2165	general secretion pathway protein
CCZ37_RS01570	COG1077	Cell shape determining protein MreB Mrl
CCZ37_RS01575	COG1792	Involved in formation and maintenance of cell shape
CCZ37_RS01580	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CCZ37_RS01585	COG0424	maF-like protein
CCZ37_RS01595	COG3164	Protein of unknown function
CCZ37_RS01600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CCZ37_RS01605	COG0312	modulator of DNA gyrase
CCZ37_RS01610	COG2235	arginine
CCZ37_RS01630	COG0589	response to stress
CCZ37_RS01645	COG2358	TRAP transporter, solute receptor (TAXI family
CCZ37_RS01650	COG1438	arginine binding
CCZ37_RS01660	COG0531	amino acid
CCZ37_RS01665	COG0142	geranyltranstransferase activity
CCZ37_RS01675	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CCZ37_RS01680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CCZ37_RS01685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CCZ37_RS01690	COG2966	Psort location CytoplasmicMembrane, score
CCZ37_RS01695	COG3610	response to peptide
CCZ37_RS01705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CCZ37_RS01710	COG2967	ApaG domain
CCZ37_RS01715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CCZ37_RS01720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CCZ37_RS01725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCZ37_RS01730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CCZ37_RS01735	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CCZ37_RS01785	COG0741	lytic transglycosylase activity
CCZ37_RS01790	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CCZ37_RS01805	COG2066	Belongs to the glutaminase family
CCZ37_RS01810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CCZ37_RS01815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CCZ37_RS01825	COG1872	DUF167
CCZ37_RS01830	COG0762	integral membrane protein
CCZ37_RS01835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CCZ37_RS01840	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CCZ37_RS01855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CCZ37_RS01860	COG1678	Uncharacterized ACR, COG1678
CCZ37_RS01870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CCZ37_RS01875	COG2356	endonuclease I
CCZ37_RS01880	COG3091	SprT-like family
CCZ37_RS01885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CCZ37_RS01890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CCZ37_RS01920	COG2433	Pfam Transposase IS66
CCZ37_RS01935	COG2184	nucleotidyltransferase activity
CCZ37_RS01945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CCZ37_RS01950	COG0126	phosphoglycerate kinase activity
CCZ37_RS01960	COG0191	fructose-bisphosphate aldolase activity
CCZ37_RS01965	COG0668	transmembrane transport
CCZ37_RS02000	COG1349	DNA-binding transcription factor activity
CCZ37_RS02040	COG3501	Rhs element vgr protein
CCZ37_RS02045	COG4104	PAAR repeat-containing protein
CCZ37_RS02090	COG2433	Pfam Transposase IS66
CCZ37_RS02110	COG3550	peptidyl-serine autophosphorylation
CCZ37_RS02130	COG0358	DNA primase activity
CCZ37_RS02135	COG1610	YqeY-like protein
CCZ37_RS02140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CCZ37_RS02145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CCZ37_RS02160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CCZ37_RS02165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CCZ37_RS02170	COG1968	undecaprenyl-diphosphatase activity
CCZ37_RS02175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CCZ37_RS02180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CCZ37_RS02185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CCZ37_RS02190	COG0585	pseudouridine synthase activity
CCZ37_RS02195	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CCZ37_RS02200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CCZ37_RS02210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CCZ37_RS02215	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CCZ37_RS02235	COG4208	sulfate ABC transporter
CCZ37_RS02240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CCZ37_RS02245	COG1546	Belongs to the CinA family
CCZ37_RS02250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CCZ37_RS02255	COG2137	regulation of response to DNA damage stimulus
CCZ37_RS02260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CCZ37_RS02265	COG0527	aspartate kinase activity
CCZ37_RS02270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CCZ37_RS02315	COG3630	sodium ion export across plasma membrane
CCZ37_RS02320	COG5016	pyruvate
CCZ37_RS02320	COG0511	ligase activity, forming carbon-carbon bonds
CCZ37_RS02325	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CCZ37_RS02335	COG1238	metal cluster binding
CCZ37_RS02340	COG0612	Peptidase, M16
CCZ37_RS02350	COG1854	S-ribosylhomocysteine lyase activity
CCZ37_RS02355	COG4536	flavin adenine dinucleotide binding
CCZ37_RS02360	COG4137	Cytochrome C assembly protein
CCZ37_RS02365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CCZ37_RS02370	COG0228	four-way junction DNA binding
CCZ37_RS02375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CCZ37_RS02380	COG0336	Belongs to the RNA methyltransferase TrmD family
CCZ37_RS02385	COG0335	large ribosomal subunit rRNA binding
CCZ37_RS02395	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CCZ37_RS02400	COG0237	dephospho-CoA kinase activity
CCZ37_RS02410	COG1459	type II secretion system
CCZ37_RS02415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CCZ37_RS02425	COG0157	Belongs to the NadC ModD family
CCZ37_RS02435	COG0716	FMN binding
CCZ37_RS02440	COG4974	Belongs to the 'phage' integrase family
CCZ37_RS02445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CCZ37_RS02450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CCZ37_RS02455	COG2186	Transcriptional regulator
CCZ37_RS02460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CCZ37_RS02465	COG0508	dehydrogenase complex catalyzes the overall conversion of
CCZ37_RS02470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCZ37_RS02485	COG0288	reversible hydration of carbon dioxide
CCZ37_RS02490	COG0659	secondary active sulfate transmembrane transporter activity
CCZ37_RS02495	COG1131	(ABC) transporter
CCZ37_RS02500	COG0842	Transport permease protein
CCZ37_RS02520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CCZ37_RS02530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCZ37_RS02540	COG1489	DNA binding
CCZ37_RS02545	COG1643	Atp-dependent helicase
CCZ37_RS02550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CCZ37_RS02555	COG1752	Esterase of the alpha-beta hydrolase superfamily
CCZ37_RS02560	COG1049	propionate catabolic process, 2-methylcitrate cycle
CCZ37_RS02595	COG1121	(ABC) transporter
CCZ37_RS02600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CCZ37_RS02610	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS02620	COG4771	TonB-dependent receptor
CCZ37_RS02625	COG1929	Belongs to the glycerate kinase type-1 family
CCZ37_RS02630	COG3112	Uncharacterised protein family (UPF0231)
CCZ37_RS02640	COG0004	ammonium transporteR
CCZ37_RS02645	COG1840	ABC-type Fe3 transport system, periplasmic component
CCZ37_RS02655	COG3842	ATPase activity
CCZ37_RS02660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CCZ37_RS02675	COG2971	BadF BadG BcrA BcrD
CCZ37_RS02685	COG4608	Belongs to the ABC transporter superfamily
CCZ37_RS02690	COG0444	Belongs to the ABC transporter superfamily
CCZ37_RS02695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCZ37_RS02710	COG2205	protein histidine kinase activity
CCZ37_RS02710	COG0784	Response regulator, receiver
CCZ37_RS02720	COG0628	permease
CCZ37_RS02725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CCZ37_RS02730	COG0316	Belongs to the HesB IscA family
CCZ37_RS02745	COG0739	heme binding
CCZ37_RS02750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CCZ37_RS02760	COG2027	D-alanyl-D-alanine carboxypeptidase
CCZ37_RS02765	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CCZ37_RS02770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CCZ37_RS02775	COG1534	Rna-binding protein
CCZ37_RS02780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CCZ37_RS02785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CCZ37_RS02790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CCZ37_RS02795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CCZ37_RS02800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CCZ37_RS02815	COG0779	Required for maturation of 30S ribosomal subunits
CCZ37_RS02820	COG0195	Participates in both transcription termination and antitermination
CCZ37_RS02825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CCZ37_RS02830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CCZ37_RS02835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CCZ37_RS02840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CCZ37_RS02855	COG1846	Transcriptional regulator
CCZ37_RS02865	COG0826	peptidase U32
CCZ37_RS02870	COG0826	peptidase U32
CCZ37_RS02880	COG3154	lipid carrier protein
CCZ37_RS02885	COG3153	acetyltransferase
CCZ37_RS02910	COG0513	Belongs to the DEAD box helicase family
CCZ37_RS02915	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CCZ37_RS02930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CCZ37_RS02935	COG2204	response regulator
CCZ37_RS02945	COG0667	Aldo Keto reductase
CCZ37_RS02955	COG0494	nUDIX hydrolase
CCZ37_RS02965	COG0730	response to heat
CCZ37_RS02975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CCZ37_RS02980	COG1283	sodium-dependent phosphate transmembrane transporter activity
CCZ37_RS02985	COG0583	DNA-binding transcription factor activity
CCZ37_RS02990	COG0640	Transcriptional regulator
CCZ37_RS02995	COG0268	Binds directly to 16S ribosomal RNA
CCZ37_RS03000	COG0728	peptidoglycan biosynthetic process
CCZ37_RS03005	COG0196	riboflavin kinase activity
CCZ37_RS03015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CCZ37_RS03020	COG1047	Peptidyl-prolyl cis-trans
CCZ37_RS03025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CCZ37_RS03030	COG1966	Carbon starvation protein
CCZ37_RS03040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CCZ37_RS03045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CCZ37_RS03055	COG3279	Response regulator of the LytR AlgR family
CCZ37_RS03060	COG3275	phosphorelay sensor kinase activity
CCZ37_RS03065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCZ37_RS03070	COG1605	Chorismate mutase
CCZ37_RS03070	COG0287	Prephenate dehydrogenase
CCZ37_RS03080	COG0488	(ABC) transporter
CCZ37_RS03090	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CCZ37_RS03095	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CCZ37_RS03100	COG5001	Diguanylate cyclase
CCZ37_RS03105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CCZ37_RS03110	COG1605	Chorismate mutase
CCZ37_RS03110	COG0077	Prephenate dehydratase
CCZ37_RS03115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CCZ37_RS03120	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCZ37_RS03125	COG0564	pseudouridine synthase activity
CCZ37_RS03130	COG1496	oxidoreductase activity
CCZ37_RS03135	COG0542	response to heat
CCZ37_RS03175	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCZ37_RS03180	COG0826	peptidase U32
CCZ37_RS03190	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS03195	COG5002	protein histidine kinase activity
CCZ37_RS03205	COG0248	Ppx GppA phosphatase
CCZ37_RS03210	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CCZ37_RS03220	COG0581	inorganic phosphate transmembrane transporter activity
CCZ37_RS03225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CCZ37_RS03230	COG0704	Plays a role in the regulation of phosphate uptake
CCZ37_RS03240	COG0450	alkyl hydroperoxide reductase
CCZ37_RS03245	COG0583	DNA-binding transcription factor activity
CCZ37_RS03250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CCZ37_RS03260	COG0517	IMP dehydrogenase activity
CCZ37_RS03270	COG0343	queuine tRNA-ribosyltransferase activity
CCZ37_RS03275	COG1862	Preprotein translocase
CCZ37_RS03280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCZ37_RS03285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCZ37_RS03290	COG0483	inositol monophosphate 1-phosphatase activity
CCZ37_RS03295	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CCZ37_RS03300	COG1959	2 iron, 2 sulfur cluster binding
CCZ37_RS03310	COG0822	iron-sulfur transferase activity
CCZ37_RS03315	COG0316	Belongs to the HesB IscA family
CCZ37_RS03320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CCZ37_RS03325	COG0443	Heat shock 70 kDa protein
CCZ37_RS03330	COG0633	Ferredoxin
CCZ37_RS03335	COG2975	iron-sulfur cluster assembly
CCZ37_RS03340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CCZ37_RS03360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CCZ37_RS03365	COG0124	histidyl-tRNA synthetase
CCZ37_RS03370	COG2976	Protein conserved in bacteria
CCZ37_RS03375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCZ37_RS03380	COG1160	GTP binding
CCZ37_RS03395	COG0516	GMP reductase activity
CCZ37_RS03395	COG0517	IMP dehydrogenase activity
CCZ37_RS03400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CCZ37_RS03400	COG0519	Catalyzes the synthesis of GMP from XMP
CCZ37_RS03405	COG0351	phosphomethylpyrimidine kinase
CCZ37_RS03415	COG1584	GPR1 FUN34 yaaH family protein
CCZ37_RS03420	COG1115	amino acid carrier protein
CCZ37_RS03425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CCZ37_RS03450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCZ37_RS03450	COG3711	transcriptional antiterminator
CCZ37_RS03465	COG3964	amidohydrolase
CCZ37_RS03495	COG0556	nucleotide-excision repair
CCZ37_RS03520	COG1686	Belongs to the peptidase S11 family
CCZ37_RS03550	COG2867	negative regulation of translational initiation
CCZ37_RS03555	COG2914	Belongs to the UPF0125 (RnfH) family
CCZ37_RS03560	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCZ37_RS03565	COG0497	DNA recombination
CCZ37_RS03570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CCZ37_RS03575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CCZ37_RS03580	COG0443	Heat shock 70 kDa protein
CCZ37_RS03585	COG0484	heat shock protein binding
CCZ37_RS03615	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CCZ37_RS03625	COG0590	tRNA wobble adenosine to inosine editing
CCZ37_RS03630	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CCZ37_RS03655	COG0442	prolyl-tRNA aminoacylation
CCZ37_RS03660	COG1720	tRNA m6t6A37 methyltransferase activity
CCZ37_RS03665	COG0254	rRNA binding
CCZ37_RS03670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CCZ37_RS03700	COG3098	single-species biofilm formation
CCZ37_RS03705	COG0564	pseudouridine synthase activity
CCZ37_RS03710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CCZ37_RS03715	COG0142	geranyltranstransferase activity
CCZ37_RS03720	COG1722	exodeoxyribonuclease VII activity
CCZ37_RS03725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CCZ37_RS03735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCZ37_RS03735	COG0301	tRNA thio-modification
CCZ37_RS03740	COG0583	DNA-binding transcription factor activity
CCZ37_RS03745	COG2363	Small membrane protein
CCZ37_RS03750	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CCZ37_RS03755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CCZ37_RS03760	COG1611	Belongs to the LOG family
CCZ37_RS03785	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CCZ37_RS03790	COG1464	Belongs to the NlpA lipoprotein family
CCZ37_RS03795	COG2011	ABC-type metal ion transport system permease component
CCZ37_RS03800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CCZ37_RS03805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CCZ37_RS03820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCZ37_RS03820	COG1263	PTS System
CCZ37_RS03825	COG0366	Alpha amylase catalytic
CCZ37_RS03855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ37_RS03860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCZ37_RS03865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CCZ37_RS03870	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CCZ37_RS03875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CCZ37_RS03880	COG1045	serine acetyltransferase
CCZ37_RS03900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CCZ37_RS03920	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CCZ37_RS03960	COG0489	protein tyrosine kinase activity
CCZ37_RS03965	COG1596	polysaccharide export
CCZ37_RS03990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CCZ37_RS03995	COG0321	lipoyl(octanoyl) transferase activity
CCZ37_RS04000	COG2921	Belongs to the UPF0250 family
CCZ37_RS04005	COG1686	Belongs to the peptidase S11 family
CCZ37_RS04010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CCZ37_RS04015	COG0772	Belongs to the SEDS family
CCZ37_RS04020	COG0768	penicillin binding
CCZ37_RS04025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CCZ37_RS04030	COG0799	negative regulation of ribosome biogenesis
CCZ37_RS04035	COG1466	dna polymerase III delta subunit
CCZ37_RS04040	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CCZ37_RS04045	COG0495	leucyl-tRNA aminoacylation
CCZ37_RS04050	COG2888	peptidyl-tyrosine sulfation
CCZ37_RS04055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CCZ37_RS04060	COG4535	Mg2 and Co2 transporter CorC
CCZ37_RS04065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CCZ37_RS04070	COG1702	phosphate starvation-inducible protein PhoH
CCZ37_RS04075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CCZ37_RS04080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCZ37_RS04085	COG2190	(PTS) system
CCZ37_RS04090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCZ37_RS04095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCZ37_RS04100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CCZ37_RS04105	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CCZ37_RS04110	COG3115	cell septum assembly
CCZ37_RS04115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CCZ37_RS04130	COG0789	Transcriptional regulator
CCZ37_RS04140	COG0330	HflC and HflK could
CCZ37_RS04145	COG3118	belongs to the thioredoxin family
CCZ37_RS04150	COG1090	epimerase
CCZ37_RS04155	COG0622	Phosphoesterase
CCZ37_RS04170	COG3710	Transcriptional regulator
CCZ37_RS04175	COG0326	Molecular chaperone. Has ATPase activity
CCZ37_RS04185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CCZ37_RS04190	COG3104	oligopeptide transport
CCZ37_RS04200	COG0367	asparagine synthase
CCZ37_RS04205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CCZ37_RS04205	COG4651	solute:proton antiporter activity
CCZ37_RS04210	COG1940	carbohydrate kinase activity
CCZ37_RS04210	COG1846	Transcriptional regulator
CCZ37_RS04215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CCZ37_RS04220	COG2190	(PTS) system
CCZ37_RS04220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCZ37_RS04220	COG1263	PTS System
CCZ37_RS04225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCZ37_RS04235	COG0101	tRNA pseudouridine synthase activity
CCZ37_RS04240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CCZ37_RS04245	COG0285	dihydrofolate synthase activity
CCZ37_RS04250	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CCZ37_RS04255	COG1286	toxin biosynthetic process
CCZ37_RS04260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CCZ37_RS04265	COG2056	Na+-H+ antiporter family
CCZ37_RS04270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CCZ37_RS04280	COG0346	lactoylglutathione lyase activity
CCZ37_RS04285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CCZ37_RS04290	COG4660	Part of a membrane complex involved in electron transport
CCZ37_RS04295	COG4659	FMN binding
CCZ37_RS04305	COG4656	Part of a membrane complex involved in electron transport
CCZ37_RS04310	COG2878	Part of a membrane complex involved in electron transport
CCZ37_RS04315	COG4657	Part of a membrane complex involved in electron transport
CCZ37_RS04325	COG1629	transport
CCZ37_RS04325	COG4774	siderophore transport
CCZ37_RS04330	COG2382	esterase
CCZ37_RS04350	COG1535	isochorismatase
CCZ37_RS04350	COG3433	isochorismatase activity
CCZ37_RS04355	COG1021	2,3-dihydroxybenzoate-AMP ligase
CCZ37_RS04360	COG1169	isochorismate synthase
CCZ37_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ37_RS04370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCZ37_RS04380	COG4771	TonB-dependent receptor
CCZ37_RS04385	COG0657	acetylesterase activity
CCZ37_RS04435	COG2194	sulfuric ester hydrolase activity
CCZ37_RS04440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CCZ37_RS04445	COG1368	sulfuric ester hydrolase activity
CCZ37_RS04465	COG5001	Diguanylate cyclase
CCZ37_RS04465	COG4251	negative regulation of phosphorylation
CCZ37_RS04465	COG3706	GGDEF domain
CCZ37_RS04465	COG2203	Gaf domain
CCZ37_RS04470	COG0784	Response regulator, receiver
CCZ37_RS04470	COG2205	protein histidine kinase activity
CCZ37_RS04470	COG5002	protein histidine kinase activity
CCZ37_RS04485	COG5002	protein histidine kinase activity
CCZ37_RS04485	COG3850	Histidine kinase
CCZ37_RS04505	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CCZ37_RS04520	COG0800	Aldolase
CCZ37_RS04545	COG0784	Response regulator, receiver
CCZ37_RS04545	COG5002	protein histidine kinase activity
CCZ37_RS04550	COG1716	ATPase activity
CCZ37_RS04550	COG5001	Diguanylate cyclase
CCZ37_RS04560	COG0601	transmembrane transport
CCZ37_RS04565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCZ37_RS04570	COG0444	Belongs to the ABC transporter superfamily
CCZ37_RS04580	COG0435	Glutathione S-transferase
CCZ37_RS04585	COG0280	phosphate acetyltransferase
CCZ37_RS04585	COG0857	belongs to the CobB CobQ family
CCZ37_RS04590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CCZ37_RS04595	COG3092	negative regulation of chromosome organization
CCZ37_RS04605	COG4120	Belongs to the binding-protein-dependent transport system permease family
CCZ37_RS04615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CCZ37_RS04620	COG0653	protein targeting
CCZ37_RS04630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CCZ37_RS04635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CCZ37_RS04645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CCZ37_RS04650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CCZ37_RS04660	COG2226	methyltransferase
CCZ37_RS04665	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CCZ37_RS04675	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CCZ37_RS04680	COG2186	Transcriptional regulator
CCZ37_RS04695	COG0537	adenosine 5'-monophosphoramidase activity
CCZ37_RS04720	COG3150	esterase
CCZ37_RS04725	COG1252	NADH dehydrogenase
CCZ37_RS04740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CCZ37_RS04750	COG4591	ABC-type transport system involved in lipoprotein release permease component
CCZ37_RS04755	COG1136	(ABC) transporter
CCZ37_RS04760	COG4591	ABC-type transport system involved in lipoprotein release permease component
CCZ37_RS04770	COG0658	competence protein
CCZ37_RS04770	COG2333	competence protein COMEC
CCZ37_RS04775	COG1132	(ABC) transporter
CCZ37_RS04790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CCZ37_RS04795	COG2719	SpoVR family
CCZ37_RS04800	COG2718	Belongs to the UPF0229 family
CCZ37_RS04805	COG2766	serine protein kinase
CCZ37_RS04810	COG3013	Belongs to the UPF0304 family
CCZ37_RS04815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CCZ37_RS04830	COG1882	Formate acetyltransferase
CCZ37_RS04860	COG4160	amino acid transport
CCZ37_RS04865	COG0708	Exodeoxyribonuclease III
CCZ37_RS04920	COG3923	Primosomal replication protein n
CCZ37_RS04930	COG1199	ATP-dependent helicase activity
CCZ37_RS04935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CCZ37_RS04940	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CCZ37_RS04945	COG3012	SEC-C Motif Domain Protein
CCZ37_RS04950	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CCZ37_RS04955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCZ37_RS04960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CCZ37_RS04965	COG0215	cysteine-tRNA ligase activity
CCZ37_RS04970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CCZ37_RS04975	COG0632	four-way junction helicase activity
CCZ37_RS04980	COG2255	four-way junction helicase activity
CCZ37_RS04985	COG1271	oxidase subunit
CCZ37_RS04990	COG1294	oxidase, subunit
CCZ37_RS04995	COG4890	Cyd operon protein YbgT
CCZ37_RS05000	COG3790	cyd operon protein YbgE
CCZ37_RS05005	COG0824	Thioesterase
CCZ37_RS05010	COG0811	peptide transport
CCZ37_RS05025	COG0823	Involved in the tonB-independent uptake of proteins
CCZ37_RS05030	COG2885	chlorophyll binding
CCZ37_RS05035	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CCZ37_RS05040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CCZ37_RS05050	COG5002	protein histidine kinase activity
CCZ37_RS05050	COG0784	Response regulator, receiver
CCZ37_RS05075	COG0747	negative chemotaxis
CCZ37_RS05085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCZ37_RS05090	COG0444	Belongs to the ABC transporter superfamily
CCZ37_RS05095	COG4608	Belongs to the ABC transporter superfamily
CCZ37_RS05105	COG1609	Transcriptional regulator
CCZ37_RS05115	COG4580	involved in the transport of maltose and maltodextrins
CCZ37_RS05130	COG1472	Belongs to the glycosyl hydrolase 3 family
CCZ37_RS05140	COG1012	belongs to the aldehyde dehydrogenase family
CCZ37_RS05160	COG1960	acyl-CoA dehydrogenase activity
CCZ37_RS05165	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CCZ37_RS05195	COG0247	lactate metabolic process
CCZ37_RS05195	COG0277	FAD linked oxidase domain protein
CCZ37_RS05210	COG2986	histidine ammonia-lyase
CCZ37_RS05220	COG0010	Belongs to the arginase family
CCZ37_RS05225	COG1228	amidohydrolase
CCZ37_RS05230	COG2188	Transcriptional regulator
CCZ37_RS05235	COG3097	Belongs to the UPF0267 family
CCZ37_RS05240	COG3099	Belongs to the UPF0263 family
CCZ37_RS05245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CCZ37_RS05255	COG0417	DNA replication proofreading
CCZ37_RS05260	COG2197	response regulator
CCZ37_RS05265	COG0322	excinuclease ABC activity
CCZ37_RS05300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CCZ37_RS05305	COG0072	phenylalanine-tRNA ligase activity
CCZ37_RS05305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCZ37_RS05310	COG0776	regulation of translation
CCZ37_RS05320	COG0500	methyltransferase
CCZ37_RS05340	COG1346	cytolysis
CCZ37_RS05345	COG1380	Effector of murein hydrolase LrgA
CCZ37_RS05350	COG2925	Exonuclease
CCZ37_RS05355	COG1823	symporter activity
CCZ37_RS05380	COG2994	toxin metabolic process
CCZ37_RS05385	COG3064	Membrane
CCZ37_RS05385	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CCZ37_RS05385	COG1073	alpha beta
CCZ37_RS05390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CCZ37_RS05395	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CCZ37_RS05410	COG2988	succinylglutamate desuccinylase activity
CCZ37_RS05415	COG4139	cobalamin transport
CCZ37_RS05420	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CCZ37_RS05440	COG0583	DNA-binding transcription factor activity
CCZ37_RS05450	COG1451	nucleotide metabolic process
CCZ37_RS05465	COG3063	Type IV pilus biogenesis stability protein PilW
CCZ37_RS05490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ37_RS05505	COG3290	protein histidine kinase activity
CCZ37_RS05510	COG4565	transcriptional regulatory protein
CCZ37_RS05520	COG0784	Response regulator, receiver
CCZ37_RS05520	COG0835	chemotaxis
CCZ37_RS05555	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CCZ37_RS05585	COG2116	formate transmembrane transporter activity
CCZ37_RS05590	COG4459	periplasmic nitrate reductase
CCZ37_RS05595	COG3005	denitrification pathway
CCZ37_RS05600	COG0243	molybdopterin cofactor binding
CCZ37_RS05620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCZ37_RS05625	COG1215	transferase activity, transferring glycosyl groups
CCZ37_RS05630	COG0438	transferase activity, transferring glycosyl groups
CCZ37_RS05665	COG0438	transferase activity, transferring glycosyl groups
CCZ37_RS05675	COG2204	response regulator
CCZ37_RS05720	COG1227	inorganic diphosphatase activity
CCZ37_RS05740	COG4172	Belongs to the ABC transporter superfamily
CCZ37_RS05750	COG4171	peptide transport system, permease
CCZ37_RS05765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CCZ37_RS05770	COG1842	Phage shock protein A
CCZ37_RS05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ37_RS05790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ37_RS05800	COG0519	Catalyzes the synthesis of GMP from XMP
CCZ37_RS05805	COG0626	cystathionine gamma-synthase activity
CCZ37_RS05815	COG0733	neurotransmitter:sodium symporter activity
CCZ37_RS05820	COG0564	pseudouridine synthase activity
CCZ37_RS05830	COG2200	EAL domain
CCZ37_RS05835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CCZ37_RS05840	COG4136	ATPase activity
CCZ37_RS05845	COG4135	transport system, permease component
CCZ37_RS05850	COG4134	Bacterial extracellular solute-binding protein
CCZ37_RS05860	COG3313	Fe-S protein
CCZ37_RS05875	COG0513	Belongs to the DEAD box helicase family
CCZ37_RS05885	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CCZ37_RS05890	COG2205	protein histidine kinase activity
CCZ37_RS05905	COG1061	Type III restriction enzyme res subunit
CCZ37_RS05910	COG1187	pseudouridine synthase activity
CCZ37_RS05915	COG2814	Major facilitator Superfamily
CCZ37_RS05925	COG0702	epimerase
CCZ37_RS05930	COG0534	Mate efflux family protein
CCZ37_RS05935	COG4181	ATPase activity
CCZ37_RS05950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CCZ37_RS06000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCZ37_RS06005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCZ37_RS06010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CCZ37_RS06020	COG0840	transmembrane signaling receptor activity
CCZ37_RS06035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCZ37_RS06035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCZ37_RS06035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCZ37_RS06040	COG2207	Transcriptional regulator
CCZ37_RS06050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCZ37_RS06060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CCZ37_RS06065	COG5002	protein histidine kinase activity
CCZ37_RS06070	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS06100	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CCZ37_RS06105	COG0372	Belongs to the citrate synthase family
CCZ37_RS06110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CCZ37_RS06115	COG2828	Protein conserved in bacteria
CCZ37_RS06130	COG0561	phosphatase activity
CCZ37_RS06135	COG0602	queuosine metabolic process
CCZ37_RS06205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CCZ37_RS06210	COG1254	Belongs to the acylphosphatase family
CCZ37_RS06215	COG2920	part of a sulfur-relay system
CCZ37_RS06220	COG0670	Belongs to the BI1 family
CCZ37_RS06225	COG1126	abc transporter atp-binding protein
CCZ37_RS06230	COG0765	amino acid transport
CCZ37_RS06235	COG4597	amino acid ABC transporter
CCZ37_RS06240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCZ37_RS06245	COG1648	precorrin-2 dehydrogenase activity
CCZ37_RS06245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CCZ37_RS06250	COG1666	GTP binding
CCZ37_RS06255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCZ37_RS06260	COG0574	Belongs to the PEP-utilizing enzyme family
CCZ37_RS06260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCZ37_RS06285	COG3008	intermembrane lipid transfer
CCZ37_RS06290	COG2995	paraquat-inducible protein a
CCZ37_RS06295	COG1132	(ABC) transporter
CCZ37_RS06300	COG1956	GAF domain-containing protein
CCZ37_RS06305	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CCZ37_RS06320	COG0308	aminopeptidase N
CCZ37_RS06330	COG2902	Dehydrogenase
CCZ37_RS06335	COG0167	dihydroorotate dehydrogenase activity
CCZ37_RS06345	COG0116	Belongs to the methyltransferase superfamily
CCZ37_RS06345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CCZ37_RS06355	COG0488	(ABC) transporter
CCZ37_RS06370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CCZ37_RS06375	COG1067	ATP-dependent peptidase activity
CCZ37_RS06380	COG3120	sequence-specific DNA binding
CCZ37_RS06400	COG3278	Belongs to the heme-copper respiratory oxidase family
CCZ37_RS06415	COG2010	Cytochrome c
CCZ37_RS06425	COG2217	Heavy metal translocating P-type atpase
CCZ37_RS06440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCZ37_RS06445	COG0589	response to stress
CCZ37_RS06470	COG3842	ATPase activity
CCZ37_RS06475	COG1176	ABC-type spermidine putrescine transport system, permease component I
CCZ37_RS06480	COG1177	transmembrane transport
CCZ37_RS06485	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CCZ37_RS06495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CCZ37_RS06500	COG0488	(ABC) transporter
CCZ37_RS06505	COG0746	molybdenum cofactor guanylyltransferase activity
CCZ37_RS06510	COG1763	Mo-molybdopterin cofactor biosynthetic process
CCZ37_RS06520	COG1940	carbohydrate kinase activity
CCZ37_RS06525	COG3148	PFAM DTW domain containing protein
CCZ37_RS06535	COG0791	NLP P60 protein
CCZ37_RS06545	COG3001	Fructosamine kinase
CCZ37_RS06560	COG1793	dna ligase
CCZ37_RS06565	COG4667	esterase of the alpha-beta hydrolase superfamily
CCZ37_RS06580	COG0848	biopolymer transport protein
CCZ37_RS06585	COG0811	peptide transport
CCZ37_RS06590	COG0811	peptide transport
CCZ37_RS06615	COG0625	glutathione transferase activity
CCZ37_RS06625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CCZ37_RS06645	COG1115	amino acid carrier protein
CCZ37_RS06650	COG1280	lysine exporter protein (LysE YggA)
CCZ37_RS06655	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CCZ37_RS06660	COG0477	Major facilitator Superfamily
CCZ37_RS06675	COG1643	Atp-dependent helicase
CCZ37_RS06695	COG3706	GGDEF domain
CCZ37_RS06735	COG1609	Transcriptional regulator
CCZ37_RS06740	COG2723	6-phospho-beta-galactosidase activity
CCZ37_RS06745	COG0513	Belongs to the DEAD box helicase family
CCZ37_RS06750	COG0243	molybdopterin cofactor binding
CCZ37_RS06755	COG3005	denitrification pathway
CCZ37_RS06760	COG1278	Cold shock
CCZ37_RS06775	COG4191	Histidine kinase
CCZ37_RS06775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCZ37_RS06780	COG0471	metal ion transport
CCZ37_RS06790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CCZ37_RS06805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCZ37_RS06815	COG3768	UPF0283 membrane protein
CCZ37_RS06820	COG3106	COG3106 Predicted ATPase
CCZ37_RS06845	COG0814	amino acid
CCZ37_RS06850	COG1760	l-serine dehydratase
CCZ37_RS06855	COG0589	response to stress
CCZ37_RS06860	COG2111	Na H antiporter
CCZ37_RS06860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CCZ37_RS06865	COG1006	Multisubunit Na H antiporter MnhC subunit
CCZ37_RS06870	COG0651	ATP synthesis coupled electron transport
CCZ37_RS06875	COG1863	multisubunit Na H antiporter MnhE subunit
CCZ37_RS06880	COG2212	antiporter activity
CCZ37_RS06885	COG1320	monovalent cation:proton antiporter activity
CCZ37_RS06895	COG2356	endonuclease I
CCZ37_RS06900	COG0720	synthase
CCZ37_RS06910	COG0017	Asparaginyl-tRNA synthetase
CCZ37_RS06920	COG2201	protein-glutamate methylesterase activity
CCZ37_RS06925	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CCZ37_RS06930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CCZ37_RS06935	COG0835	chemotaxis
CCZ37_RS06945	COG0643	Histidine kinase
CCZ37_RS06945	COG2198	Histidine kinase
CCZ37_RS06955	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS06965	COG1448	Aminotransferase
CCZ37_RS06970	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CCZ37_RS06980	COG0840	transmembrane signaling receptor activity
CCZ37_RS06990	COG1846	Transcriptional regulator
CCZ37_RS07005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CCZ37_RS07010	COG3108	Peptidase M15
CCZ37_RS07015	COG2989	Protein conserved in bacteria
CCZ37_RS07045	COG1940	carbohydrate kinase activity
CCZ37_RS07050	COG1629	transport
CCZ37_RS07050	COG4771	TonB-dependent receptor
CCZ37_RS07055	COG3023	N-Acetylmuramoyl-L-alanine amidase
CCZ37_RS07060	COG0748	coenzyme F420 binding
CCZ37_RS07065	COG3721	Heme iron utilization protein
CCZ37_RS07075	COG0811	peptide transport
CCZ37_RS07080	COG0848	biopolymer transport protein
CCZ37_RS07090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCZ37_RS07095	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CCZ37_RS07100	COG1054	Belongs to the UPF0176 family
CCZ37_RS07115	COG1621	beta-fructofuranosidase activity
CCZ37_RS07125	COG1263	PTS System
CCZ37_RS07125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCZ37_RS07130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCZ37_RS07135	COG2200	EAL domain
CCZ37_RS07140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CCZ37_RS07145	COG0840	transmembrane signaling receptor activity
CCZ37_RS07150	COG1294	oxidase, subunit
CCZ37_RS07155	COG1271	oxidase subunit
CCZ37_RS07175	COG3220	belongs to the UPF0276 family
CCZ37_RS07195	COG1294	oxidase, subunit
CCZ37_RS07205	COG0251	oxidation-reduction process
CCZ37_RS07275	COG1518	maintenance of DNA repeat elements
CCZ37_RS07330	COG4790	Type iii secretion
CCZ37_RS07345	COG3710	Transcriptional regulator
CCZ37_RS07380	COG4789	Type iii secretion
CCZ37_RS07460	COG3710	Transcriptional regulator
CCZ37_RS07465	COG2198	Histidine kinase
CCZ37_RS07465	COG0784	Response regulator, receiver
CCZ37_RS07465	COG2205	protein histidine kinase activity
CCZ37_RS07465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCZ37_RS07480	COG1435	thymidine kinase activity
CCZ37_RS07485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CCZ37_RS07495	COG0500	methyltransferase
CCZ37_RS07500	COG0189	ligase activity
CCZ37_RS07500	COG4067	protein conserved in archaea
CCZ37_RS07515	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CCZ37_RS07520	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CCZ37_RS07530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CCZ37_RS07535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CCZ37_RS07540	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS07550	COG1609	Transcriptional regulator
CCZ37_RS07555	COG3070	regulator of competence-specific genes
CCZ37_RS07575	COG0297	glycogen (starch) synthase activity
CCZ37_RS07580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CCZ37_RS07585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CCZ37_RS07600	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CCZ37_RS07605	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CCZ37_RS07610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CCZ37_RS07615	COG0542	response to heat
CCZ37_RS07620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CCZ37_RS07625	COG1278	Cold shock
CCZ37_RS07635	COG1187	pseudouridine synthase activity
CCZ37_RS07640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CCZ37_RS07640	COG0140	phosphoribosyl-ATP diphosphatase activity
CCZ37_RS07645	COG0107	imidazoleglycerol-phosphate synthase activity
CCZ37_RS07650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CCZ37_RS07655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CCZ37_RS07660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CCZ37_RS07660	COG0131	Imidazoleglycerol-phosphate dehydratase
CCZ37_RS07665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CCZ37_RS07670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CCZ37_RS07675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CCZ37_RS07680	COG1757	Na H antiporter
CCZ37_RS07685	COG2916	Histone family protein nucleoid-structuring protein H-NS
CCZ37_RS07690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCZ37_RS07700	COG0482	sulfurtransferase activity
CCZ37_RS07705	COG2915	High frequency lysogenization protein hflD homolog
CCZ37_RS07710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CCZ37_RS07715	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CCZ37_RS07725	COG4191	Histidine kinase
CCZ37_RS07725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCZ37_RS07740	COG3070	regulator of competence-specific genes
CCZ37_RS07750	COG2431	L-lysine efflux transmembrane transporter activity
CCZ37_RS07760	COG0076	glutamate decarboxylase activity
CCZ37_RS07765	COG1737	Transcriptional regulator
CCZ37_RS07770	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CCZ37_RS07775	COG2985	domain, Protein
CCZ37_RS07775	COG3273	potassium ion transport
CCZ37_RS07780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CCZ37_RS07790	COG0281	malic enzyme
CCZ37_RS07800	COG2949	membrane
CCZ37_RS07820	COG0492	ferredoxin-NADP+ reductase activity
CCZ37_RS07825	COG4988	ABC transporter
CCZ37_RS07830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CCZ37_RS07835	COG1187	pseudouridine synthase activity
CCZ37_RS07840	COG0009	L-threonylcarbamoyladenylate synthase
CCZ37_RS07845	COG0613	PHP domain protein
CCZ37_RS07855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CCZ37_RS07860	COG0512	Glutamine amidotransferase of anthranilate synthase
CCZ37_RS07865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CCZ37_RS07870	COG0134	indole-3-glycerol-phosphate synthase activity
CCZ37_RS07870	COG0135	phosphoribosylanthranilate isomerase activity
CCZ37_RS07875	COG0133	tryptophan synthase activity
CCZ37_RS07880	COG0159	tryptophan synthase activity
CCZ37_RS07905	COG2350	Protein conserved in bacteria
CCZ37_RS07915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CCZ37_RS07920	COG0583	DNA-binding transcription factor activity
CCZ37_RS07935	COG2203	Gaf domain
CCZ37_RS07935	COG2199	diguanylate cyclase activity
CCZ37_RS07935	COG2200	EAL domain
CCZ37_RS07940	COG5640	endopeptidase activity
CCZ37_RS07945	COG1032	radical SAM domain protein
CCZ37_RS07955	COG2268	Band 7 protein
CCZ37_RS07965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CCZ37_RS07980	COG0300	oxidoreductase activity
CCZ37_RS07990	COG0501	Belongs to the peptidase M48B family
CCZ37_RS08000	COG1674	ftsk spoiiie
CCZ37_RS08005	COG1522	sequence-specific DNA binding
CCZ37_RS08010	COG0686	Belongs to the AlaDH PNT family
CCZ37_RS08020	COG0583	DNA-binding transcription factor activity
CCZ37_RS08035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CCZ37_RS08040	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CCZ37_RS08045	COG0776	regulation of translation
CCZ37_RS08050	COG0539	negative regulation of cytoplasmic translation
CCZ37_RS08055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CCZ37_RS08060	COG1555	photosystem II stabilization
CCZ37_RS08065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCZ37_RS08070	COG0776	regulation of translation
CCZ37_RS08075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CCZ37_RS08080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CCZ37_RS08090	COG0544	peptidyl-prolyl cis-trans isomerase activity
CCZ37_RS08105	COG1653	transport
CCZ37_RS08110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CCZ37_RS08115	COG1760	l-serine dehydratase
CCZ37_RS08125	COG0513	Belongs to the DEAD box helicase family
CCZ37_RS08135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CCZ37_RS08150	COG4628	conserved protein (DUF2132)
CCZ37_RS08155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CCZ37_RS08165	COG0732	type I restriction modification DNA specificity domain
CCZ37_RS08170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CCZ37_RS08185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CCZ37_RS08190	COG0583	DNA-binding transcription factor activity
CCZ37_RS08195	COG2951	lytic endotransglycosylase activity
CCZ37_RS08200	COG3100	YcgL domain-containing protein
CCZ37_RS08210	COG2894	cell division
CCZ37_RS08215	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CCZ37_RS08220	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CCZ37_RS08225	COG0318	PFAM AMP-dependent synthetase and ligase
CCZ37_RS08230	COG0596	Alpha beta hydrolase
CCZ37_RS08245	COG1214	PFAM Peptidase M22, glycoprotease
CCZ37_RS08250	COG1199	ATP-dependent helicase activity
CCZ37_RS08260	COG0788	formyltetrahydrofolate deformylase activity
CCZ37_RS08265	COG1902	pentaerythritol trinitrate reductase activity
CCZ37_RS08265	COG0446	pyridine nucleotide-disulphide oxidoreductase
CCZ37_RS08270	COG0616	signal peptide processing
CCZ37_RS08275	COG0252	asparaginase activity
CCZ37_RS08280	COG3139	Protein of unknown function (DUF1315)
CCZ37_RS08290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CCZ37_RS08305	COG2226	methyltransferase
CCZ37_RS08320	COG2983	Belongs to the UPF0260 family
CCZ37_RS08330	COG3706	GGDEF domain
CCZ37_RS08335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CCZ37_RS08350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CCZ37_RS08355	COG2832	Protein of unknown function (DUF454)
CCZ37_RS08365	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS08370	COG0583	DNA-binding transcription factor activity
CCZ37_RS08380	COG1024	Enoyl-CoA hydratase
CCZ37_RS08380	COG1250	3-hydroxyacyl-CoA dehydrogenase
CCZ37_RS08385	COG0183	Belongs to the thiolase family
CCZ37_RS08400	COG1595	DNA-templated transcription, initiation
CCZ37_RS08410	COG2067	long-chain fatty acid transport protein
CCZ37_RS08415	COG2067	long-chain fatty acid transport protein
CCZ37_RS08420	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CCZ37_RS08425	COG2982	Protein involved in outer membrane biogenesis
CCZ37_RS08430	COG0572	uridine kinase
CCZ37_RS08435	COG0489	protein tyrosine kinase activity
CCZ37_RS08440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCZ37_RS08440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCZ37_RS08450	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CCZ37_RS08460	COG0617	tRNA 3'-terminal CCA addition
CCZ37_RS08460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CCZ37_RS08460	COG0517	IMP dehydrogenase activity
CCZ37_RS08465	COG2199	diguanylate cyclase activity
CCZ37_RS08470	COG0314	molybdopterin synthase activity
CCZ37_RS08475	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CCZ37_RS08485	COG0521	Mo-molybdopterin cofactor biosynthetic process
CCZ37_RS08490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CCZ37_RS08495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CCZ37_RS08500	COG2198	Histidine kinase
CCZ37_RS08505	COG2204	response regulator
CCZ37_RS08510	COG0556	nucleotide-excision repair
CCZ37_RS08520	COG3706	GGDEF domain
CCZ37_RS08545	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CCZ37_RS08550	COG1946	Acyl-CoA thioesterase
CCZ37_RS08555	COG1522	sequence-specific DNA binding
CCZ37_RS08595	COG0318	PFAM AMP-dependent synthetase and ligase
CCZ37_RS08605	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CCZ37_RS08615	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CCZ37_RS08620	COG1169	isochorismate synthase
CCZ37_RS08630	COG0436	Aminotransferase
CCZ37_RS08635	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CCZ37_RS08640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CCZ37_RS08655	COG0616	signal peptide processing
CCZ37_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ37_RS08665	COG0784	Response regulator, receiver
CCZ37_RS08665	COG0835	chemotaxis
CCZ37_RS08670	COG1940	carbohydrate kinase activity
CCZ37_RS08680	COG4667	esterase of the alpha-beta hydrolase superfamily
CCZ37_RS08695	COG0733	neurotransmitter:sodium symporter activity
CCZ37_RS08705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCZ37_RS08705	COG1263	PTS System
CCZ37_RS08710	COG0084	hydrolase, TatD family'
CCZ37_RS08715	COG0470	DNA polymerase III
CCZ37_RS08720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CCZ37_RS08725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CCZ37_RS08730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CCZ37_RS08755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CCZ37_RS08770	COG1399	metal-binding, possibly nucleic acid-binding protein
CCZ37_RS08775	COG0424	maF-like protein
CCZ37_RS08780	COG0564	pseudouridine synthase activity
CCZ37_RS08785	COG1530	ribonuclease E activity
CCZ37_RS08795	COG1012	belongs to the aldehyde dehydrogenase family
CCZ37_RS08795	COG1454	alcohol dehydrogenase
CCZ37_RS08800	COG2095	MarC family integral membrane protein
CCZ37_RS08805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CCZ37_RS08810	COG1757	Na H antiporter
CCZ37_RS08825	COG3082	Protein of unknown function (DUF1414)
CCZ37_RS08840	COG0243	molybdopterin cofactor binding
CCZ37_RS08845	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CCZ37_RS08860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CCZ37_RS08865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CCZ37_RS08885	COG2853	Lipoprotein
CCZ37_RS08900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CCZ37_RS08905	COG1138	Cytochrome C-type biogenesis protein
CCZ37_RS08910	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CCZ37_RS08920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CCZ37_RS08925	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CCZ37_RS08930	COG4133	protoheme IX ABC transporter activity
CCZ37_RS08940	COG0835	chemotaxis
CCZ37_RS08950	COG1192	Involved in chromosome partitioning
CCZ37_RS08955	COG2201	protein-glutamate methylesterase activity
CCZ37_RS08965	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CCZ37_RS08990	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CCZ37_RS08995	COG2062	phosphohistidine phosphatase, SixA
CCZ37_RS09000	COG1025	Belongs to the peptidase M16 family
CCZ37_RS09005	COG3102	Protein conserved in bacteria
CCZ37_RS09030	COG1918	ferrous iron import across plasma membrane
CCZ37_RS09035	COG4977	sequence-specific DNA binding
CCZ37_RS09040	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CCZ37_RS09045	COG1121	(ABC) transporter
CCZ37_RS09050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CCZ37_RS09065	COG0508	dehydrogenase complex catalyzes the overall conversion of
CCZ37_RS09070	COG0567	Dehydrogenase, E1 component
CCZ37_RS09085	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CCZ37_RS09100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CCZ37_RS09110	COG0033	Phosphoglucomutase
CCZ37_RS09115	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CCZ37_RS09120	COG0596	Alpha beta hydrolase
CCZ37_RS09135	COG1346	cytolysis
CCZ37_RS09145	COG0583	DNA-binding transcription factor activity
CCZ37_RS09155	COG0735	belongs to the Fur family
CCZ37_RS09160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CCZ37_RS09165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CCZ37_RS09170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CCZ37_RS09175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CCZ37_RS09175	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CCZ37_RS09180	COG0431	NADPH-dependent FMN reductase
CCZ37_RS09190	COG3101	peptidyl-lysine hydroxylation
CCZ37_RS09195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CCZ37_RS09200	COG2890	protein-(glutamine-N5) methyltransferase activity
CCZ37_RS09205	COG2840	Smr protein MutS2
CCZ37_RS09215	COG1684	flagellar biosynthetic protein fliR
CCZ37_RS09220	COG1987	bacterial-type flagellum assembly
CCZ37_RS09270	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCZ37_RS09280	COG1677	Flagellar hook-basal body complex protein FliE
CCZ37_RS09300	COG1516	flagellar protein fliS
CCZ37_RS09310	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CCZ37_RS09335	COG2837	iron assimilation
CCZ37_RS09360	COG1393	Belongs to the ArsC family
CCZ37_RS09380	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CCZ37_RS09395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CCZ37_RS09415	COG4783	chaperone-mediated protein folding
CCZ37_RS09420	COG1393	Belongs to the ArsC family
CCZ37_RS09440	COG2233	PERMEase
CCZ37_RS09445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CCZ37_RS09455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CCZ37_RS09460	COG2912	Transglutaminase-like superfamily
CCZ37_RS09465	COG3094	Invasion gene expression up-regulator, SirB
CCZ37_RS09470	COG2890	protein-(glutamine-N5) methyltransferase activity
CCZ37_RS09475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CCZ37_RS09480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CCZ37_RS09485	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CCZ37_RS09490	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CCZ37_RS09495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CCZ37_RS09500	COG0193	aminoacyl-tRNA hydrolase activity
CCZ37_RS09605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCZ37_RS09615	COG1705	Flagellar rod assembly protein muramidase FlgJ
CCZ37_RS09615	COG3951	Flagellar rod assembly protein muramidase FlgJ
CCZ37_RS09620	COG1706	bacterial-type flagellum-dependent cell motility
CCZ37_RS09625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CCZ37_RS09635	COG4787	bacterial-type flagellum-dependent cell motility
CCZ37_RS09640	COG1749	Flagellar hook protein flgE
CCZ37_RS09655	COG1815	bacterial-type flagellum-dependent cell motility
CCZ37_RS09665	COG0784	Response regulator, receiver
CCZ37_RS09665	COG0835	chemotaxis
CCZ37_RS09675	COG2747	anti-sigma28 factor FlgM
CCZ37_RS09720	COG2217	Heavy metal translocating P-type atpase
CCZ37_RS09720	COG2608	mercury ion transmembrane transporter activity
CCZ37_RS09750	COG1187	pseudouridine synthase activity
CCZ37_RS09755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CCZ37_RS09760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CCZ37_RS09765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CCZ37_RS09770	COG0121	glutamine amidotransferase
CCZ37_RS09775	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CCZ37_RS09795	COG0328	RNA-DNA hybrid ribonuclease activity
CCZ37_RS09800	COG2226	methyltransferase
CCZ37_RS09805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CCZ37_RS09810	COG0741	lytic transglycosylase activity
CCZ37_RS09810	COG1388	LysM domain
CCZ37_RS09820	COG3021	interspecies interaction between organisms
CCZ37_RS09825	COG0347	Belongs to the P(II) protein family
CCZ37_RS09830	COG3479	Phenolic acid decarboxylase
CCZ37_RS09840	COG0037	tRNA processing
CCZ37_RS09845	COG0825	malonyl-CoA metabolic process
CCZ37_RS09850	COG0587	DNA-directed DNA polymerase activity
CCZ37_RS09860	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCZ37_RS09870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CCZ37_RS09875	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCZ37_RS09880	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CCZ37_RS09890	COG0750	zinc metalloprotease
CCZ37_RS09895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CCZ37_RS09900	COG0575	Belongs to the CDS family
CCZ37_RS09905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CCZ37_RS09910	COG0233	cytoplasmic translational termination
CCZ37_RS09920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CCZ37_RS09925	COG0052	Belongs to the universal ribosomal protein uS2 family
CCZ37_RS09930	COG0024	Methionine aminopeptidase
CCZ37_RS09935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CCZ37_RS09945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CCZ37_RS09950	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CCZ37_RS09955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CCZ37_RS09975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CCZ37_RS09975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CCZ37_RS09980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CCZ37_RS09985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CCZ37_RS09990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CCZ37_RS10000	COG1073	alpha beta
CCZ37_RS10005	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CCZ37_RS10010	COG2252	PERMEase
CCZ37_RS10015	COG2195	Cleaves the N-terminal amino acid of tripeptides
CCZ37_RS10020	COG0189	ligase activity
CCZ37_RS10020	COG4067	protein conserved in archaea
CCZ37_RS10025	COG0189	ligase activity
CCZ37_RS10035	COG0733	neurotransmitter:sodium symporter activity
CCZ37_RS10040	COG5001	Diguanylate cyclase
CCZ37_RS10040	COG4251	negative regulation of phosphorylation
CCZ37_RS10040	COG3706	GGDEF domain
CCZ37_RS10040	COG2203	Gaf domain
CCZ37_RS10050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CCZ37_RS10060	COG1477	protein flavinylation
CCZ37_RS10070	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CCZ37_RS10095	COG0271	Belongs to the BolA IbaG family
CCZ37_RS10100	COG2813	Specifically methylates the guanine in position
CCZ37_RS10115	COG2211	Major facilitator Superfamily
CCZ37_RS10125	COG1595	DNA-templated transcription, initiation
CCZ37_RS10140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CCZ37_RS10145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CCZ37_RS10150	COG2166	iron-sulfur cluster assembly
CCZ37_RS10155	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CCZ37_RS10160	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CCZ37_RS10170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CCZ37_RS10170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CCZ37_RS10180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CCZ37_RS10185	COG1074	ATP-dependent DNA helicase activity
CCZ37_RS10190	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CCZ37_RS10205	COG3141	response to X-ray
CCZ37_RS10210	COG2171	N-acyltransferase activity
CCZ37_RS10240	COG3437	response regulator, receiver
CCZ37_RS10240	COG0784	Response regulator, receiver
CCZ37_RS10250	COG4628	conserved protein (DUF2132)
CCZ37_RS10255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CCZ37_RS10260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CCZ37_RS10270	COG0560	Phosphoserine phosphatase
CCZ37_RS10280	COG0813	purine-nucleoside phosphorylase activity
CCZ37_RS10285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CCZ37_RS10290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CCZ37_RS10295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CCZ37_RS10300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CCZ37_RS10305	COG0084	hydrolase, TatD family'
CCZ37_RS10310	COG3022	response to hydroperoxide
CCZ37_RS10315	COG1115	amino acid carrier protein
CCZ37_RS10330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CCZ37_RS10340	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CCZ37_RS10345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CCZ37_RS10350	COG0083	homoserine kinase activity
CCZ37_RS10370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CCZ37_RS10375	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS10380	COG2198	Histidine kinase
CCZ37_RS10380	COG5002	protein histidine kinase activity
CCZ37_RS10380	COG0784	Response regulator, receiver
CCZ37_RS10385	COG1242	4 iron, 4 sulfur cluster binding
CCZ37_RS10390	COG0070	glutamate synthase
CCZ37_RS10390	COG0067	glutamate synthase
CCZ37_RS10390	COG0069	glutamate synthase activity
CCZ37_RS10400	COG0070	glutamate synthase
CCZ37_RS10400	COG0069	glutamate synthase activity
CCZ37_RS10400	COG0067	glutamate synthase
CCZ37_RS10405	COG0493	'glutamate synthase
CCZ37_RS10415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CCZ37_RS10425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CCZ37_RS10430	COG2860	membrane
CCZ37_RS10435	COG0730	response to heat
CCZ37_RS10450	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CCZ37_RS10465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CCZ37_RS10470	COG0505	Belongs to the CarA family
CCZ37_RS10475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CCZ37_RS10480	COG0494	nUDIX hydrolase
CCZ37_RS10485	COG0653	protein targeting
CCZ37_RS10495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CCZ37_RS10500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CCZ37_RS10505	COG0849	cell division
CCZ37_RS10510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CCZ37_RS10515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CCZ37_RS10520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CCZ37_RS10525	COG0772	Belongs to the SEDS family
CCZ37_RS10530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CCZ37_RS10540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CCZ37_RS10545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CCZ37_RS10550	COG0768	penicillin binding
CCZ37_RS10555	COG3116	cell division
CCZ37_RS10560	COG0275	rRNA processing
CCZ37_RS10570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CCZ37_RS10575	COG3107	peptidoglycan biosynthetic process
CCZ37_RS10580	COG0792	nuclease activity
CCZ37_RS10585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CCZ37_RS10595	COG2969	positive regulation of protein catabolic process
CCZ37_RS10600	COG0625	glutathione transferase activity
CCZ37_RS10605	COG2857	Cytochrome c1
CCZ37_RS10610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CCZ37_RS10615	COG0723	plastoquinol--plastocyanin reductase activity
CCZ37_RS10625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CCZ37_RS10635	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CCZ37_RS10640	COG3105	Protein conserved in bacteria
CCZ37_RS10645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCZ37_RS10650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCZ37_RS10655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CCZ37_RS10660	COG0187	DNA topoisomerase II activity
CCZ37_RS10665	COG3150	esterase
CCZ37_RS10675	COG3151	Protein conserved in bacteria
CCZ37_RS10680	COG0494	nUDIX hydrolase
CCZ37_RS10685	COG1538	Outer membrane efflux protein
CCZ37_RS10695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CCZ37_RS10705	COG3025	triphosphatase activity
CCZ37_RS10710	COG1392	Phosphate transport regulator
CCZ37_RS10715	COG0306	phosphate transporter
CCZ37_RS10720	COG4991	sh3 domain protein
CCZ37_RS10730	COG3409	Peptidoglycan-binding domain 1 protein
CCZ37_RS10730	COG3267	Type II secretory pathway component ExeA
CCZ37_RS10735	COG0617	tRNA 3'-terminal CCA addition
CCZ37_RS10745	COG0504	CTP synthase activity
CCZ37_RS10750	COG3956	TIGRFAM MazG family protein
CCZ37_RS10755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CCZ37_RS10760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CCZ37_RS10765	COG3437	response regulator, receiver
CCZ37_RS10765	COG3850	Histidine kinase
CCZ37_RS10765	COG2205	protein histidine kinase activity
CCZ37_RS10765	COG4999	Histidine kinase
CCZ37_RS10770	COG0736	holo-[acyl-carrier-protein] synthase activity
CCZ37_RS10775	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CCZ37_RS10780	COG1381	Involved in DNA repair and RecF pathway recombination
CCZ37_RS10785	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CCZ37_RS10790	COG0571	ribonuclease III activity
CCZ37_RS10800	COG0481	GTPase activity
CCZ37_RS10805	COG3086	response to oxidative stress
CCZ37_RS10820	COG1595	DNA-templated transcription, initiation
CCZ37_RS10825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CCZ37_RS10835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CCZ37_RS10855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCZ37_RS10860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCZ37_RS10865	COG3079	Belongs to the UPF0149 family
CCZ37_RS10870	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CCZ37_RS10880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CCZ37_RS10890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CCZ37_RS10900	COG0028	Belongs to the TPP enzyme family
CCZ37_RS10905	COG1022	Amp-dependent synthetase and ligase
CCZ37_RS10910	COG0583	DNA-binding transcription factor activity
CCZ37_RS10930	COG0473	3-isopropylmalate dehydrogenase activity
CCZ37_RS10940	COG0066	3-isopropylmalate dehydratase activity
CCZ37_RS11040	COG0795	lipopolysaccharide-transporting ATPase activity
CCZ37_RS11045	COG0795	lipopolysaccharide-transporting ATPase activity
CCZ37_RS11050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CCZ37_RS11055	COG2927	DNA polymerase III (CHI subunit)
CCZ37_RS11060	COG0525	valine-tRNA ligase activity
CCZ37_RS11065	COG0564	pseudouridine synthase activity
CCZ37_RS11075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CCZ37_RS11085	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CCZ37_RS11100	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CCZ37_RS11105	COG0251	oxidation-reduction process
CCZ37_RS11110	COG0204	Acyl-transferase
CCZ37_RS11115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CCZ37_RS11120	COG5007	Belongs to the BolA IbaG family
CCZ37_RS11130	COG2854	intermembrane phospholipid transfer
CCZ37_RS11135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CCZ37_RS11140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CCZ37_RS11145	COG1127	ABC transporter
CCZ37_RS11155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CCZ37_RS11155	COG0517	IMP dehydrogenase activity
CCZ37_RS11160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CCZ37_RS11170	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CCZ37_RS11175	COG1137	ATPase activity
CCZ37_RS11185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CCZ37_RS11190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCZ37_RS11195	COG1660	Displays ATPase and GTPase activities
CCZ37_RS11200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCZ37_RS11205	COG2239	Acts as a magnesium transporter
CCZ37_RS11210	COG0312	modulator of DNA gyrase
CCZ37_RS11215	COG3028	Belongs to the UPF0307 family
CCZ37_RS11220	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CCZ37_RS11225	COG1178	ABC-type Fe3 transport system permease component
CCZ37_RS11235	COG0163	prenyltransferase activity
CCZ37_RS11240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CCZ37_RS11245	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CCZ37_RS11250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CCZ37_RS11255	COG2105	PFAM AIG2 family protein
CCZ37_RS11260	COG2911	Protein conserved in bacteria
CCZ37_RS11265	COG0729	surface antigen
CCZ37_RS11270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CCZ37_RS11275	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CCZ37_RS11310	COG0529	Catalyzes the synthesis of activated sulfate
CCZ37_RS11315	COG2895	sulfate adenylyltransferase (ATP) activity
CCZ37_RS11325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CCZ37_RS11325	COG1648	precorrin-2 dehydrogenase activity
CCZ37_RS11330	COG0737	Belongs to the 5'-nucleotidase family
CCZ37_RS11340	COG0513	Belongs to the DEAD box helicase family
CCZ37_RS11345	COG2153	protein acetylation
CCZ37_RS11350	COG3266	domain, Protein
CCZ37_RS11350	COG3061	Opacity-associated protein A
CCZ37_RS11355	COG0545	Peptidyl-prolyl cis-trans isomerase
CCZ37_RS11360	COG0203	ribosomal protein L17
CCZ37_RS11365	COG0202	RNA polymerase activity
CCZ37_RS11370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CCZ37_RS11375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CCZ37_RS11380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CCZ37_RS11385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CCZ37_RS11390	COG0201	protein transport
CCZ37_RS11395	COG0200	Binds to the 23S rRNA
CCZ37_RS11400	COG1841	ribosomal large subunit assembly
CCZ37_RS11405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CCZ37_RS11415	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CCZ37_RS11420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CCZ37_RS11425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CCZ37_RS11430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CCZ37_RS11435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CCZ37_RS11445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CCZ37_RS11455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CCZ37_RS11470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CCZ37_RS11475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CCZ37_RS11485	COG0088	Forms part of the polypeptide exit tunnel
CCZ37_RS11490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CCZ37_RS11495	COG0051	transcription antitermination factor activity, RNA binding
CCZ37_RS11500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CCZ37_RS11505	COG0557	exoribonuclease II activity
CCZ37_RS11510	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CCZ37_RS11520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CCZ37_RS11530	COG1047	Peptidyl-prolyl cis-trans
CCZ37_RS11535	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CCZ37_RS11545	COG2249	NAD(P)H dehydrogenase (quinone) activity
CCZ37_RS11550	COG0488	(ABC) transporter
CCZ37_RS11560	COG0429	hydrolase of the alpha beta-hydrolase fold
CCZ37_RS11570	COG3954	Phosphoribulokinase
CCZ37_RS11575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCZ37_RS11585	COG1012	belongs to the aldehyde dehydrogenase family
CCZ37_RS11595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CCZ37_RS11650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCZ37_RS11660	COG0583	DNA-binding transcription factor activity
CCZ37_RS11675	COG0180	Tryptophanyl-tRNA synthetase
CCZ37_RS11680	COG0546	phosphoglycolate phosphatase activity
CCZ37_RS11685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CCZ37_RS11690	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CCZ37_RS11700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CCZ37_RS11705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CCZ37_RS11735	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CCZ37_RS11745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CCZ37_RS11745	COG0678	peroxiredoxin activity
CCZ37_RS11750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCZ37_RS11760	COG0165	Argininosuccinate lyase
CCZ37_RS11760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CCZ37_RS11765	COG0137	argininosuccinate synthase activity
CCZ37_RS11770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CCZ37_RS11775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CCZ37_RS11780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CCZ37_RS11785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CCZ37_RS11795	COG1045	serine acetyltransferase
CCZ37_RS11800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CCZ37_RS11810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCZ37_RS11815	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CCZ37_RS11820	COG1053	succinate dehydrogenase
CCZ37_RS11825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CCZ37_RS11830	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CCZ37_RS11840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CCZ37_RS11845	COG1509	lysine 2,3-aminomutase activity
CCZ37_RS11860	COG0459	protein refolding
CCZ37_RS11865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CCZ37_RS11895	COG0534	Mate efflux family protein
CCZ37_RS11900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CCZ37_RS11905	COG1575	Belongs to the MenA family. Type 1 subfamily
CCZ37_RS11915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CCZ37_RS11925	COG1609	Transcriptional regulator
CCZ37_RS11930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CCZ37_RS11940	COG0281	malic enzyme
CCZ37_RS11950	COG0626	cystathionine gamma-synthase activity
CCZ37_RS11955	COG0460	homoserine dehydrogenase
CCZ37_RS11955	COG0527	aspartate kinase activity
CCZ37_RS11960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CCZ37_RS11965	COG3074	FtsZ-dependent cytokinesis
CCZ37_RS11970	COG1494	fructose-1,6-bisphosphatase
CCZ37_RS11975	COG0205	6-phosphofructokinase activity
CCZ37_RS11980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CCZ37_RS11990	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS11995	COG2205	protein histidine kinase activity
CCZ37_RS12000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CCZ37_RS12005	COG1278	Cold shock
CCZ37_RS12020	COG1027	Aspartate ammonia-lyase
CCZ37_RS12025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CCZ37_RS12030	COG1288	antiporter activity
CCZ37_RS12045	COG0549	Belongs to the carbamate kinase family
CCZ37_RS12050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CCZ37_RS12060	COG0540	Belongs to the ATCase OTCase family
CCZ37_RS12065	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CCZ37_RS12070	COG1438	arginine binding
CCZ37_RS12075	COG4232	protein-disulfide reductase activity
CCZ37_RS12095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CCZ37_RS12100	COG0784	Response regulator, receiver
CCZ37_RS12100	COG2205	protein histidine kinase activity
CCZ37_RS12100	COG2198	Histidine kinase
CCZ37_RS12105	COG2814	Major facilitator Superfamily
CCZ37_RS12120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CCZ37_RS12125	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CCZ37_RS12130	COG0511	ligase activity, forming carbon-carbon bonds
CCZ37_RS12135	COG0439	Biotin carboxylase
CCZ37_RS12140	COG2264	protein methyltransferase activity
CCZ37_RS12145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CCZ37_RS12150	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CCZ37_RS12160	COG1982	Orn Lys Arg decarboxylase major
CCZ37_RS12165	COG0531	amino acid
CCZ37_RS12170	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CCZ37_RS12175	COG3710	Transcriptional regulator
CCZ37_RS12180	COG0789	Transcriptional regulator
CCZ37_RS12185	COG0138	bifunctional purine biosynthesis protein purh
CCZ37_RS12190	COG0151	Belongs to the GarS family
CCZ37_RS12200	COG0776	regulation of translation
CCZ37_RS12205	COG1253	flavin adenine dinucleotide binding
CCZ37_RS12215	COG3068	Protein conserved in bacteria
CCZ37_RS12220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CCZ37_RS12225	COG0668	transmembrane transport
CCZ37_RS12230	COG0840	transmembrane signaling receptor activity
CCZ37_RS12235	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CCZ37_RS12240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CCZ37_RS12245	COG3366	ferrous iron transmembrane transporter activity
CCZ37_RS12250	COG0700	Nucleoside recognition
CCZ37_RS12255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CCZ37_RS12290	COG0438	transferase activity, transferring glycosyl groups
CCZ37_RS12305	COG0463	Glycosyl transferase, family 2
CCZ37_RS12305	COG1216	Glycosyl transferase, family 2
CCZ37_RS12340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CCZ37_RS12370	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCZ37_RS12380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCZ37_RS12400	COG1051	belongs to the nudix hydrolase family
CCZ37_RS12405	COG5433	transposase activity
CCZ37_RS12445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CCZ37_RS12450	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CCZ37_RS12455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CCZ37_RS12460	COG0662	Cupin 2, conserved barrel domain protein
CCZ37_RS12460	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CCZ37_RS12510	COG0859	PFAM glycosyl transferase family 9
CCZ37_RS12515	COG1519	Transferase
CCZ37_RS12520	COG0110	maltose O-acetyltransferase activity
CCZ37_RS12525	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ37_RS12530	COG1083	cytidylyl-transferase
CCZ37_RS12540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CCZ37_RS12540	COG0517	IMP dehydrogenase activity
CCZ37_RS12545	COG0110	maltose O-acetyltransferase activity
CCZ37_RS12550	COG2089	acid synthase
CCZ37_RS12555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CCZ37_RS12560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CCZ37_RS12570	COG3083	sulfuric ester hydrolase activity
CCZ37_RS12575	COG3642	lipopolysaccharide core region biosynthetic process
CCZ37_RS12580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CCZ37_RS12585	COG0859	PFAM glycosyl transferase family 9
CCZ37_RS12590	COG0463	Glycosyl transferase, family 2
CCZ37_RS12595	COG0859	PFAM glycosyl transferase family 9
CCZ37_RS12600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CCZ37_RS12615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CCZ37_RS12620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CCZ37_RS12625	COG2003	Belongs to the UPF0758 family
CCZ37_RS12635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CCZ37_RS12640	COG1309	transcriptional regulator
CCZ37_RS12645	COG1560	Kdo2-lipid A biosynthetic process
CCZ37_RS12650	COG1560	Kdo2-lipid A biosynthetic process
CCZ37_RS12655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CCZ37_RS12660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CCZ37_RS12665	COG1561	YicC-like family, N-terminal region
CCZ37_RS12675	COG3550	peptidyl-serine autophosphorylation
CCZ37_RS12680	COG3620	sequence-specific DNA binding
CCZ37_RS12720	COG1061	Type III restriction enzyme res subunit
CCZ37_RS12745	COG0612	Peptidase, M16
CCZ37_RS12750	COG2862	Uncharacterized protein family, UPF0114
CCZ37_RS12760	COG0514	ATP-dependent DNA helicase (RecQ)
CCZ37_RS12765	COG2962	Rard protein
CCZ37_RS12770	COG0405	Gamma-glutamyltransferase
CCZ37_RS12780	COG1280	lysine exporter protein (LysE YggA)
CCZ37_RS12785	COG0210	DNA helicase
CCZ37_RS12790	COG0339	signal peptide processing
CCZ37_RS12795	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CCZ37_RS12800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCZ37_RS12815	COG1566	PFAM secretion protein HlyD family protein
CCZ37_RS12830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ37_RS12840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CCZ37_RS12840	COG3008	intermembrane lipid transfer
CCZ37_RS12845	COG2995	paraquat-inducible protein a
CCZ37_RS12875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCZ37_RS12880	COG0601	transmembrane transport
CCZ37_RS12930	COG1309	transcriptional regulator
CCZ37_RS12935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ37_RS12940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCZ37_RS12945	COG2960	long-chain fatty acid transporting porin activity
CCZ37_RS12950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CCZ37_RS12970	COG3078	GTPase activator activity
CCZ37_RS12990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CCZ37_RS12990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CCZ37_RS13000	COG0084	hydrolase, TatD family'
CCZ37_RS13010	COG0805	protein transport
CCZ37_RS13015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CCZ37_RS13020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CCZ37_RS13025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CCZ37_RS13035	COG2226	methyltransferase
CCZ37_RS13040	COG1322	Protein conserved in bacteria
CCZ37_RS13045	COG0697	spore germination
CCZ37_RS13055	COG2081	HI0933 family
CCZ37_RS13070	COG1528	Iron-storage protein
CCZ37_RS13075	COG0589	response to stress
CCZ37_RS13090	COG0742	ribosomal rna small subunit methyltransferase
CCZ37_RS13095	COG1522	sequence-specific DNA binding
CCZ37_RS13115	COG0006	proline dipeptidase activity
CCZ37_RS13115	COG0006	proline dipeptidase activity
CCZ37_RS13120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CCZ37_RS13125	COG2022	thiamine diphosphate biosynthetic process
CCZ37_RS13130	COG2104	thiamine diphosphate biosynthetic process
CCZ37_RS13140	COG0352	thiamine-phosphate diphosphorylase activity
CCZ37_RS13145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CCZ37_RS13160	COG3335	DDE superfamily endonuclease
CCZ37_RS13200	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CCZ37_RS13205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CCZ37_RS13210	COG1739	Uncharacterized protein family UPF0029
CCZ37_RS13220	COG0183	Belongs to the thiolase family
CCZ37_RS13225	COG0583	DNA-binding transcription factor activity
CCZ37_RS13230	COG2814	Major facilitator Superfamily
CCZ37_RS13240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CCZ37_RS13245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CCZ37_RS13250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CCZ37_RS13255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CCZ37_RS13260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CCZ37_RS13265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CCZ37_RS13275	COG0356	it plays a direct role in the translocation of protons across the membrane
CCZ37_RS13280	COG3312	ion transport
CCZ37_RS13285	COG1475	DNA binding
CCZ37_RS13290	COG1192	Involved in chromosome partitioning
CCZ37_RS13300	COG0445	tRNA wobble uridine modification
CCZ37_RS13305	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CCZ37_RS13315	COG0706	membrane insertase activity
CCZ37_RS13335	COG1126	abc transporter atp-binding protein
CCZ37_RS13355	COG1132	(ABC) transporter
CCZ37_RS13400	COG0835	chemotaxis
CCZ37_RS13405	COG0835	chemotaxis
CCZ37_RS13415	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS13425	COG1444	tRNA N-acetyltransferase activity
CCZ37_RS13430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CCZ37_RS13470	COG2084	Dehydrogenase
CCZ37_RS13475	COG0814	amino acid
CCZ37_RS13505	COG0583	DNA-binding transcription factor activity
CCZ37_RS13510	COG2910	NAD(P)H-binding
CCZ37_RS13520	COG3304	Inner membrane component domain
CCZ37_RS13540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CCZ37_RS13570	COG0363	glucosamine-6-phosphate deaminase activity
CCZ37_RS13580	COG0739	heme binding
CCZ37_RS13585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCZ37_RS13585	COG2213	PTS system mannitol-specific
CCZ37_RS13590	COG0246	Mannitol dehydrogenase
CCZ37_RS13595	COG3722	fumarate hydratase activity
CCZ37_RS13605	COG1301	dicarboxylic acid transport
CCZ37_RS13610	COG2259	Doxx family
CCZ37_RS13625	COG1846	Transcriptional regulator
CCZ37_RS13635	COG3046	protein related to deoxyribodipyrimidine photolyase
CCZ37_RS13640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCZ37_RS13655	COG3842	ATPase activity
CCZ37_RS13665	COG1175	transmembrane transport
CCZ37_RS13685	COG0513	Belongs to the DEAD box helicase family
CCZ37_RS13695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CCZ37_RS13705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CCZ37_RS13710	COG1328	CTP reductase activity
CCZ37_RS13720	COG2130	NADP-dependent
CCZ37_RS13725	COG1309	transcriptional regulator
CCZ37_RS13740	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS13750	COG0564	pseudouridine synthase activity
CCZ37_RS13810	COG3829	transcription factor binding
CCZ37_RS13835	COG3501	Rhs element vgr protein
CCZ37_RS13835	COG3409	Peptidoglycan-binding domain 1 protein
CCZ37_RS13850	COG1869	D-ribose catabolic process
CCZ37_RS13855	COG1129	ABC transporter
CCZ37_RS13860	COG1172	Belongs to the binding-protein-dependent transport system permease family
CCZ37_RS13865	COG1879	ABC-type sugar transport system periplasmic component
CCZ37_RS13870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCZ37_RS13875	COG1609	Transcriptional regulator
CCZ37_RS13895	COG0363	glucosamine-6-phosphate deaminase activity
CCZ37_RS13900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CCZ37_RS13910	COG1067	ATP-dependent peptidase activity
CCZ37_RS13935	COG3122	Protein conserved in bacteria
CCZ37_RS13940	COG1230	cation diffusion facilitator family transporter
CCZ37_RS13950	COG1881	PFAM PEBP family protein
CCZ37_RS13960	COG1231	oxidoreductase activity
CCZ37_RS13990	COG1620	l-lactate permease
CCZ37_RS13995	COG0583	DNA-binding transcription factor activity
CCZ37_RS14000	COG2199	diguanylate cyclase activity
CCZ37_RS14000	COG2203	Gaf domain
CCZ37_RS14015	COG3527	Alpha-acetolactate decarboxylase
CCZ37_RS14025	COG0584	glycerophosphoryl diester phosphodiesterase
CCZ37_RS14030	COG2271	Major facilitator Superfamily
CCZ37_RS14055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCZ37_RS14060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CCZ37_RS14065	COG2199	diguanylate cyclase activity
CCZ37_RS14075	COG3314	Sporulation integral membrane protein YlbJ
CCZ37_RS14080	COG0659	secondary active sulfate transmembrane transporter activity
CCZ37_RS14090	COG0739	heme binding
CCZ37_RS14095	COG5001	Diguanylate cyclase
CCZ37_RS14100	COG0583	DNA-binding transcription factor activity
CCZ37_RS14105	COG2814	Major facilitator Superfamily
CCZ37_RS14125	COG0697	spore germination
CCZ37_RS14135	COG0179	Fumarylacetoacetate (FAA) hydrolase
CCZ37_RS14145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CCZ37_RS14150	COG0765	amino acid transport
CCZ37_RS14155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCZ37_RS14160	COG0765	amino acid transport
CCZ37_RS14170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCZ37_RS14180	COG3123	guanosine phosphorylase activity
CCZ37_RS14190	COG1741	Belongs to the pirin family
CCZ37_RS14200	COG5001	Diguanylate cyclase
CCZ37_RS14205	COG0583	DNA-binding transcription factor activity
CCZ37_RS14230	COG3706	GGDEF domain
CCZ37_RS14235	COG2315	Protein conserved in bacteria
CCZ37_RS14240	COG0784	Response regulator, receiver
CCZ37_RS14240	COG0835	chemotaxis
CCZ37_RS14245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCZ37_RS14255	COG3842	ATPase activity
CCZ37_RS14270	COG1175	transmembrane transport
CCZ37_RS14275	COG3833	ABC-type maltose transport systems, permease component
CCZ37_RS14305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CCZ37_RS14310	COG0418	dihydroorotase activity
CCZ37_RS14315	COG0633	Ferredoxin
CCZ37_RS14315	COG3217	Mosc domain protein beta barrel domain protein
CCZ37_RS14320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CCZ37_RS14325	COG2195	Cleaves the N-terminal amino acid of tripeptides
CCZ37_RS14335	COG3604	Transcriptional regulator
CCZ37_RS14340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CCZ37_RS14340	COG1017	nitric oxide dioxygenase activity
CCZ37_RS14345	COG4681	YaeQ
CCZ37_RS14350	COG1278	Cold shock
CCZ37_RS14375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CCZ37_RS14380	COG0516	GMP reductase activity
CCZ37_RS14390	COG3335	DDE superfamily endonuclease
CCZ37_RS14410	COG0714	Associated with various cellular activities
CCZ37_RS14420	COG2433	Pfam Transposase IS66
CCZ37_RS14450	COG1132	(ABC) transporter
CCZ37_RS14455	COG1132	(ABC) transporter
CCZ37_RS14475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CCZ37_RS14480	COG1021	2,3-dihydroxybenzoate-AMP ligase
CCZ37_RS14505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CCZ37_RS14505	COG2226	methyltransferase
CCZ37_RS14505	COG3433	isochorismatase activity
CCZ37_RS14510	COG2814	Major facilitator Superfamily
CCZ37_RS14515	COG4771	TonB-dependent receptor
CCZ37_RS14520	COG1917	Cupin 2, conserved barrel domain protein
CCZ37_RS14520	COG4977	sequence-specific DNA binding
CCZ37_RS14545	COG0589	response to stress
CCZ37_RS14550	COG0659	secondary active sulfate transmembrane transporter activity
CCZ37_RS14555	COG0640	Transcriptional regulator
CCZ37_RS14560	COG0798	PFAM Bile acid sodium symporter
CCZ37_RS14570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CCZ37_RS14580	COG0573	inorganic phosphate transmembrane transporter activity
CCZ37_RS14590	COG0640	Transcriptional regulator
CCZ37_RS14595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CCZ37_RS14620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CCZ37_RS14630	COG2271	Major facilitator Superfamily
CCZ37_RS14635	COG3851	Histidine kinase
CCZ37_RS14640	COG2197	response regulator
CCZ37_RS14655	COG0346	lactoylglutathione lyase activity
CCZ37_RS14665	COG0156	8-amino-7-oxononanoate synthase activity
CCZ37_RS14670	COG1063	alcohol dehydrogenase
CCZ37_RS14685	COG1063	alcohol dehydrogenase
CCZ37_RS14725	COG2258	MOSC domain
CCZ37_RS14740	COG3227	Zinc metalloprotease (Elastase)
CCZ37_RS14745	COG3530	Putative quorum-sensing-regulated virulence factor
CCZ37_RS14755	COG3706	GGDEF domain
CCZ37_RS14770	COG2304	oxidoreductase activity
CCZ37_RS14790	COG0714	Associated with various cellular activities
CCZ37_RS14805	COG0366	Alpha amylase catalytic
CCZ37_RS14840	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CCZ37_RS14845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CCZ37_RS14855	COG0456	acetyltransferase
CCZ37_RS14860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CCZ37_RS14865	COG0662	Cupin 2, conserved barrel domain protein
CCZ37_RS14870	COG0527	aspartate kinase activity
CCZ37_RS14890	COG1166	arginine decarboxylase activity
CCZ37_RS14895	COG0010	Belongs to the arginase family
CCZ37_RS14915	COG3300	MHYT domain
CCZ37_RS14915	COG5001	Diguanylate cyclase
CCZ37_RS14920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCZ37_RS14945	COG0484	heat shock protein binding
CCZ37_RS14955	COG1716	ATPase activity
CCZ37_RS14955	COG5001	Diguanylate cyclase
CCZ37_RS14960	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CCZ37_RS14970	COG4181	ATPase activity
CCZ37_RS14975	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CCZ37_RS14985	COG1984	allophanate hydrolase subunit 2
CCZ37_RS14995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CCZ37_RS15000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CCZ37_RS15005	COG0814	amino acid
CCZ37_RS15010	COG0513	Belongs to the DEAD box helicase family
CCZ37_RS15020	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CCZ37_RS15035	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CCZ37_RS15070	COG3023	N-Acetylmuramoyl-L-alanine amidase
CCZ37_RS15080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CCZ37_RS15095	COG1648	precorrin-2 dehydrogenase activity
CCZ37_RS15095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CCZ37_RS15100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CCZ37_RS15120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CCZ37_RS15125	COG0247	lactate metabolic process
CCZ37_RS15130	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CCZ37_RS15135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CCZ37_RS15140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CCZ37_RS15145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CCZ37_RS15165	COG3132	Protein of unknown function, DUF480
CCZ37_RS15170	COG2827	Endonuclease containing a URI domain
CCZ37_RS15180	COG1879	ABC-type sugar transport system periplasmic component
CCZ37_RS15185	COG5002	protein histidine kinase activity
CCZ37_RS15185	COG0784	Response regulator, receiver
CCZ37_RS15215	COG1289	transmembrane transporter activity
CCZ37_RS15220	COG0210	DNA helicase
CCZ37_RS15225	COG1803	Methylglyoxal synthase
CCZ37_RS15230	COG1879	ABC-type sugar transport system periplasmic component
CCZ37_RS15235	COG2205	protein histidine kinase activity
CCZ37_RS15235	COG2198	Histidine kinase
CCZ37_RS15235	COG0784	Response regulator, receiver
CCZ37_RS15240	COG0469	pyruvate kinase activity
CCZ37_RS15245	COG2271	Major facilitator Superfamily
CCZ37_RS15270	COG1979	alcohol dehydrogenase
CCZ37_RS15275	COG2207	Transcriptional regulator
CCZ37_RS15285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CCZ37_RS15300	COG3111	PFAM Bacterial OB fold (BOF) protein
CCZ37_RS15305	COG1492	cobalamin metabolic process
CCZ37_RS15310	COG0725	ABC transporter, periplasmic molybdate-binding protein
CCZ37_RS15315	COG4149	molybdate abc transporter
CCZ37_RS15320	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CCZ37_RS15330	COG3706	GGDEF domain
CCZ37_RS15330	COG4251	negative regulation of phosphorylation
CCZ37_RS15330	COG2203	Gaf domain
CCZ37_RS15330	COG5001	Diguanylate cyclase
CCZ37_RS15355	COG3852	Histidine kinase
CCZ37_RS15360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCZ37_RS15360	COG4191	Histidine kinase
CCZ37_RS15420	COG1328	CTP reductase activity
CCZ37_RS15425	COG0602	queuosine metabolic process
CCZ37_RS15435	COG4067	protein conserved in archaea
CCZ37_RS15435	COG0189	ligase activity
CCZ37_RS15450	COG4166	transmembrane transport
CCZ37_RS15455	COG4174	ABC transporter (Permease)
CCZ37_RS15460	COG4239	(ABC) transporter, permease
CCZ37_RS15465	COG4172	Belongs to the ABC transporter superfamily
CCZ37_RS15475	COG3038	cytochrome b561
CCZ37_RS15480	COG2353	YceI-like domain
CCZ37_RS15485	COG0840	transmembrane signaling receptor activity
CCZ37_RS15490	COG0545	Peptidyl-prolyl cis-trans isomerase
CCZ37_RS15505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CCZ37_RS15520	COG2897	thiosulfate sulfurtransferase activity
CCZ37_RS15525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CCZ37_RS15530	COG0303	'Molybdopterin
CCZ37_RS15535	COG0302	gtp cyclohydrolase
CCZ37_RS15540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CCZ37_RS15540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CCZ37_RS15545	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CCZ37_RS15550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CCZ37_RS15555	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CCZ37_RS15565	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CCZ37_RS15570	COG1011	Hydrolase
CCZ37_RS15575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CCZ37_RS15580	COG2188	Transcriptional regulator
CCZ37_RS15595	COG2116	formate transmembrane transporter activity
CCZ37_RS15600	COG0583	DNA-binding transcription factor activity
CCZ37_RS15610	COG3593	DNA synthesis involved in DNA repair
CCZ37_RS15615	COG0737	Belongs to the 5'-nucleotidase family
CCZ37_RS15620	COG0861	Integral membrane protein TerC family
CCZ37_RS15630	COG2824	Alkylphosphonate utilization operon protein PhnA
CCZ37_RS15640	COG2050	protein possibly involved in aromatic compounds catabolism
CCZ37_RS15655	COG0653	protein targeting
CCZ37_RS15660	COG0583	DNA-binding transcription factor activity
CCZ37_RS15665	COG1042	CoA-binding domain protein
CCZ37_RS15665	COG0045	succinate-CoA ligase (ADP-forming) activity
CCZ37_RS15665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCZ37_RS15675	COG1181	Belongs to the D-alanine--D-alanine ligase family
CCZ37_RS15690	COG0023	Translation Initiation Factor
CCZ37_RS15695	COG3140	Belongs to the UPF0181 family
CCZ37_RS15710	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS15720	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CCZ37_RS15725	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CCZ37_RS15745	COG1278	Cold shock
CCZ37_RS15755	COG0724	RNA recognition motif
CCZ37_RS15770	COG2501	S4 domain
CCZ37_RS15780	COG0488	(ABC) transporter
CCZ37_RS15825	COG3555	Aspartyl Asparaginyl beta-hydroxylase
CCZ37_RS15855	COG2433	Pfam Transposase IS66
CCZ37_RS15870	COG3093	addiction module antidote protein HigA
CCZ37_RS15875	COG3549	Plasmid maintenance system killer
CCZ37_RS16025	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ37_RS16425	COG2433	Pfam Transposase IS66
CCZ37_RS16550	COG0489	protein tyrosine kinase activity
CCZ37_RS16745	COG0484	heat shock protein binding
CCZ37_RS16910	COG2433	Pfam Transposase IS66
CCZ37_RS16945	COG2314	TM2 domain
CCZ37_RS17220	COG0454	-acetyltransferase
CCZ37_RS17295	COG0384	phenazine biosynthesis protein PhzF
CCZ37_RS17305	COG0346	lactoylglutathione lyase activity
CCZ37_RS17375	COG0346	lactoylglutathione lyase activity
CCZ37_RS17450	COG3040	lipid binding
CCZ37_RS17520	COG3041	Addiction module toxin RelE StbE family
CCZ37_RS17560	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ37_RS17590	COG0513	Belongs to the DEAD box helicase family
CCZ37_RS17595	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CCZ37_RS17625	COG3069	C4-dicarboxylate transmembrane transporter activity
CCZ37_RS17630	COG2197	response regulator
CCZ37_RS17635	COG3850	Histidine kinase
CCZ37_RS17640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCZ37_RS17650	COG0243	molybdopterin cofactor binding
CCZ37_RS17660	COG3005	denitrification pathway
CCZ37_RS17680	COG0183	Belongs to the thiolase family
CCZ37_RS17690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCZ37_RS17695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCZ37_RS17740	COG3675	Pfam Lipase (class 3)
CCZ37_RS17750	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CCZ37_RS17765	COG0577	efflux transmembrane transporter activity
CCZ37_RS17765	COG1136	(ABC) transporter
CCZ37_RS17775	COG1136	(ABC) transporter
CCZ37_RS17780	COG0523	cobalamin synthesis protein
CCZ37_RS17785	COG0038	chloride channel
CCZ37_RS17795	COG0156	8-amino-7-oxononanoate synthase activity
CCZ37_RS17800	COG2205	protein histidine kinase activity
CCZ37_RS17800	COG0784	Response regulator, receiver
CCZ37_RS17805	COG0419	ATPase involved in DNA repair
CCZ37_RS17810	COG0420	3'-5' exonuclease activity
CCZ37_RS17815	COG1609	Transcriptional regulator
CCZ37_RS17820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCZ37_RS17820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCZ37_RS17825	COG1105	Belongs to the carbohydrate kinase PfkB family
CCZ37_RS17830	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CCZ37_RS17830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCZ37_RS17830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCZ37_RS17870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CCZ37_RS17875	COG0509	glycine decarboxylation via glycine cleavage system
CCZ37_RS17895	COG1012	belongs to the aldehyde dehydrogenase family
CCZ37_RS17930	COG0753	catalase activity
CCZ37_RS17955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CCZ37_RS17960	COG4604	ABC transporter, ATP-binding protein
CCZ37_RS17965	COG4605	iron ion homeostasis
CCZ37_RS17970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCZ37_RS17975	COG4607	ABC-type enterochelin transport system periplasmic component
CCZ37_RS18005	COG5380	lipid catabolic process
CCZ37_RS18010	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CCZ37_RS18020	COG3240	lipase activity
CCZ37_RS18025	COG0443	Heat shock 70 kDa protein
CCZ37_RS18035	COG2814	Major facilitator Superfamily
CCZ37_RS18040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCZ37_RS18040	COG4191	Histidine kinase
CCZ37_RS18050	COG0784	Response regulator, receiver
CCZ37_RS18050	COG3437	response regulator, receiver
CCZ37_RS18055	COG0840	transmembrane signaling receptor activity
CCZ37_RS18060	COG2154	pterin-4-alpha-carbinolamine dehydratase
CCZ37_RS18065	COG3186	Phenylalanine-4-hydroxylase
CCZ37_RS18070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CCZ37_RS18075	COG0583	DNA-binding transcription factor activity
CCZ37_RS18085	COG0583	DNA-binding transcription factor activity
CCZ37_RS18100	COG0110	maltose O-acetyltransferase activity
CCZ37_RS18105	COG1765	OsmC-like protein
CCZ37_RS18110	COG0673	inositol 2-dehydrogenase activity
CCZ37_RS18115	COG0642	Histidine kinase
CCZ37_RS18125	COG2977	Belongs to the P-Pant transferase superfamily
CCZ37_RS18135	COG2130	NADP-dependent
CCZ37_RS18165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CCZ37_RS18190	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCZ37_RS18195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ37_RS18235	COG3437	response regulator, receiver
CCZ37_RS18245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CCZ37_RS18255	COG2203	Gaf domain
CCZ37_RS18255	COG3706	GGDEF domain
CCZ37_RS18255	COG4251	negative regulation of phosphorylation
CCZ37_RS18255	COG5001	Diguanylate cyclase
CCZ37_RS18260	COG4989	oxidoreductase activity
CCZ37_RS18280	COG2267	carboxylic ester hydrolase activity
CCZ37_RS18285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CCZ37_RS18300	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CCZ37_RS18310	COG0513	Belongs to the DEAD box helicase family
CCZ37_RS18320	COG1388	LysM domain
CCZ37_RS18320	COG1376	ErfK ybiS ycfS ynhG family protein
CCZ37_RS18325	COG0415	Belongs to the DNA photolyase family
CCZ37_RS18330	COG0789	Transcriptional regulator
CCZ37_RS18335	COG3272	Protein of unknown function (DUF1722)
CCZ37_RS18340	COG0813	purine-nucleoside phosphorylase activity
CCZ37_RS18365	COG1566	PFAM secretion protein HlyD family protein
CCZ37_RS18390	COG0786	glutamate:sodium symporter activity
CCZ37_RS18405	COG1999	signal sequence binding
CCZ37_RS18415	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CCZ37_RS18435	COG4580	involved in the transport of maltose and maltodextrins
CCZ37_RS18470	COG0561	phosphatase activity
CCZ37_RS18475	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CCZ37_RS18480	COG3623	hexulose-6-phosphate isomerase
CCZ37_RS18495	COG1132	(ABC) transporter
CCZ37_RS18505	COG0671	phosphoesterase, PA-phosphatase related
CCZ37_RS18525	COG0840	transmembrane signaling receptor activity
CCZ37_RS18535	COG1131	(ABC) transporter
CCZ37_RS18540	COG2188	Transcriptional regulator
CCZ37_RS18550	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CCZ37_RS18555	COG0471	metal ion transport
CCZ37_RS18605	COG3501	Rhs element vgr protein
CCZ37_RS18615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CCZ37_RS18620	COG1640	4-alpha-glucanotransferase
CCZ37_RS18625	COG0058	SHG alpha-glucan phosphorylase activity
CCZ37_RS18630	COG2909	trisaccharide binding
CCZ37_RS18650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CCZ37_RS18670	COG0840	transmembrane signaling receptor activity
CCZ37_RS18705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CCZ37_RS18710	COG0259	pyridoxamine-phosphate oxidase activity
CCZ37_RS18730	COG2274	protein secretion by the type I secretion system
CCZ37_RS18760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CCZ37_RS18765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CCZ37_RS18770	COG0840	transmembrane signaling receptor activity
CCZ37_RS18775	COG0835	chemotaxis
CCZ37_RS18780	COG0835	chemotaxis
CCZ37_RS18790	COG0745	RESPONSE REGULATOR receiver
CCZ37_RS18800	COG1444	tRNA N-acetyltransferase activity