locus-tag	class	description
IUZ65_RS00010	COG0592	DNA-directed DNA polymerase activity
IUZ65_RS00020	COG0187	DNA topoisomerase II activity
IUZ65_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
IUZ65_RS00030	COG1609	Transcriptional regulator
IUZ65_RS00035	COG0800	Aldolase
IUZ65_RS00040	COG0129	dihydroxy-acid dehydratase activity
IUZ65_RS00045	COG3265	gluconokinase activity
IUZ65_RS00050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IUZ65_RS00055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IUZ65_RS00060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IUZ65_RS00065	COG3977	Valine--pyruvate aminotransferase
IUZ65_RS00070	COG0751	glycine-tRNA ligase activity
IUZ65_RS00075	COG0752	glycyl-tRNA synthetase alpha subunit
IUZ65_RS00080	COG0425	Belongs to the sulfur carrier protein TusA family
IUZ65_RS00090	COG0604	alcohol dehydrogenase
IUZ65_RS00095	COG0183	Belongs to the thiolase family
IUZ65_RS00100	COG1024	Enoyl-CoA hydratase
IUZ65_RS00100	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUZ65_RS00105	COG1739	Uncharacterized protein family UPF0029
IUZ65_RS00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IUZ65_RS00150	COG0583	DNA-binding transcription factor activity
IUZ65_RS00155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IUZ65_RS00165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUZ65_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUZ65_RS00175	COG1309	transcriptional regulator
IUZ65_RS00220	COG0747	negative chemotaxis
IUZ65_RS00225	COG0601	transmembrane transport
IUZ65_RS00230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IUZ65_RS00240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUZ65_RS00245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IUZ65_RS00250	COG0339	signal peptide processing
IUZ65_RS00255	COG1522	sequence-specific DNA binding
IUZ65_RS00260	COG5002	protein histidine kinase activity
IUZ65_RS00260	COG5001	Diguanylate cyclase
IUZ65_RS00265	COG0742	ribosomal rna small subunit methyltransferase
IUZ65_RS00280	COG0589	response to stress
IUZ65_RS00285	COG1528	Iron-storage protein
IUZ65_RS00295	COG2081	HI0933 family
IUZ65_RS00300	COG0583	DNA-binding transcription factor activity
IUZ65_RS00305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IUZ65_RS00310	COG0583	DNA-binding transcription factor activity
IUZ65_RS00320	COG1063	alcohol dehydrogenase
IUZ65_RS00330	COG1879	ABC-type sugar transport system periplasmic component
IUZ65_RS00335	COG1129	ABC transporter
IUZ65_RS00340	COG1172	Belongs to the binding-protein-dependent transport system permease family
IUZ65_RS00345	COG1070	Carbohydrate kinase
IUZ65_RS00360	COG2731	YhcH YjgK YiaL family protein
IUZ65_RS00365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUZ65_RS00375	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IUZ65_RS00380	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IUZ65_RS00385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IUZ65_RS00395	COG0561	phosphatase activity
IUZ65_RS00410	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IUZ65_RS00415	COG1414	Transcriptional regulator
IUZ65_RS00420	COG3623	hexulose-6-phosphate isomerase
IUZ65_RS00445	COG1322	Protein conserved in bacteria
IUZ65_RS00450	COG2226	methyltransferase
IUZ65_RS00455	COG3165	ubiquinone biosynthetic process from chorismate
IUZ65_RS00460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IUZ65_RS00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IUZ65_RS00470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IUZ65_RS00475	COG0805	protein transport
IUZ65_RS00480	COG0084	hydrolase, TatD family'
IUZ65_RS00490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IUZ65_RS00490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IUZ65_RS00495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IUZ65_RS00525	COG2204	response regulator
IUZ65_RS00530	COG3852	Histidine kinase
IUZ65_RS00535	COG0174	glutamine synthetase
IUZ65_RS00540	COG1217	gtp-binding protein TYPA
IUZ65_RS00555	COG1490	D-aminoacyl-tRNA deacylase activity
IUZ65_RS00560	COG0456	acetyltransferase
IUZ65_RS00570	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IUZ65_RS00575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IUZ65_RS00580	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IUZ65_RS00585	COG3031	protein transport across the cell outer membrane
IUZ65_RS00595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IUZ65_RS00600	COG1459	type II secretion system
IUZ65_RS00605	COG2165	general secretion pathway protein
IUZ65_RS00610	COG2165	general secretion pathway protein
IUZ65_RS00615	COG2165	general secretion pathway protein
IUZ65_RS00620	COG4795	General secretion pathway protein
IUZ65_RS00625	COG3156	type II secretion system protein K
IUZ65_RS00630	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IUZ65_RS00635	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IUZ65_RS00645	COG0494	nUDIX hydrolase
IUZ65_RS00650	COG1218	3'(2'),5'-bisphosphate nucleotidase
IUZ65_RS00655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IUZ65_RS00655	COG0316	Belongs to the HesB IscA family
IUZ65_RS00660	COG1040	competence protein
IUZ65_RS00675	COG2183	response to ionizing radiation
IUZ65_RS00685	COG1595	DNA-templated transcription, initiation
IUZ65_RS00700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IUZ65_RS00705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUZ65_RS00710	COG1758	RNA polymerase activity
IUZ65_RS00715	COG0194	GDP metabolic process
IUZ65_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
IUZ65_RS00740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IUZ65_RS00745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IUZ65_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
IUZ65_RS00770	COG1561	YicC-like family, N-terminal region
IUZ65_RS00775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IUZ65_RS00785	COG1560	Kdo2-lipid A biosynthetic process
IUZ65_RS00790	COG1309	transcriptional regulator
IUZ65_RS00795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IUZ65_RS00805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IUZ65_RS00805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IUZ65_RS00810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IUZ65_RS00815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IUZ65_RS00835	COG0859	PFAM glycosyl transferase family 9
IUZ65_RS00840	COG3642	lipopolysaccharide core region biosynthetic process
IUZ65_RS00845	COG1519	Transferase
IUZ65_RS00855	COG0463	Glycosyl transferase, family 2
IUZ65_RS00865	COG1086	Polysaccharide biosynthesis protein
IUZ65_RS00870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IUZ65_RS00875	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
IUZ65_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
IUZ65_RS00900	COG2089	acid synthase
IUZ65_RS00910	COG4310	Domain of unknown function (DUF2172)
IUZ65_RS00925	COG1560	Kdo2-lipid A biosynthetic process
IUZ65_RS00960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IUZ65_RS00995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUZ65_RS01000	COG0463	Glycosyl transferase, family 2
IUZ65_RS01035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IUZ65_RS01045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IUZ65_RS01090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IUZ65_RS01095	COG4942	peptidase
IUZ65_RS01100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IUZ65_RS01105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUZ65_RS01110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IUZ65_RS01120	COG1045	serine acetyltransferase
IUZ65_RS01125	COG0534	Mate efflux family protein
IUZ65_RS01130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUZ65_RS01135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IUZ65_RS01135	COG0678	peroxiredoxin activity
IUZ65_RS01145	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IUZ65_RS01175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IUZ65_RS01185	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IUZ65_RS01190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IUZ65_RS01195	COG0546	phosphoglycolate phosphatase activity
IUZ65_RS01200	COG0180	Tryptophanyl-tRNA synthetase
IUZ65_RS01215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IUZ65_RS01235	COG1509	lysine 2,3-aminomutase activity
IUZ65_RS01240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IUZ65_RS01250	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IUZ65_RS01255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IUZ65_RS01260	COG1053	succinate dehydrogenase
IUZ65_RS01265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IUZ65_RS01275	COG0471	metal ion transport
IUZ65_RS01280	COG0688	phosphatidylethanolamine metabolic process
IUZ65_RS01285	COG1162	GTPase activity
IUZ65_RS01335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IUZ65_RS01340	COG0802	atpase or kinase
IUZ65_RS01345	COG0860	N-Acetylmuramoyl-L-alanine amidase
IUZ65_RS01350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IUZ65_RS01355	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IUZ65_RS01365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IUZ65_RS01370	COG0330	HflC and HflK could
IUZ65_RS01375	COG0330	HflC and HflK could
IUZ65_RS01380	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IUZ65_RS01390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IUZ65_RS01395	COG0088	Forms part of the polypeptide exit tunnel
IUZ65_RS01400	COG0089	rRNA binding
IUZ65_RS01405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IUZ65_RS01410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IUZ65_RS01425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IUZ65_RS01430	COG0255	Belongs to the universal ribosomal protein uL29 family
IUZ65_RS01435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IUZ65_RS01440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IUZ65_RS01445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IUZ65_RS01450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IUZ65_RS01455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IUZ65_RS01460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IUZ65_RS01465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IUZ65_RS01480	COG1841	ribosomal large subunit assembly
IUZ65_RS01485	COG0200	Binds to the 23S rRNA
IUZ65_RS01490	COG0201	protein transport
IUZ65_RS01495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IUZ65_RS01500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IUZ65_RS01515	COG0202	RNA polymerase activity
IUZ65_RS01520	COG0203	ribosomal protein L17
IUZ65_RS01525	COG2873	o-acetylhomoserine
IUZ65_RS01535	COG0545	Peptidyl-prolyl cis-trans isomerase
IUZ65_RS01550	COG2153	protein acetylation
IUZ65_RS01565	COG1648	precorrin-2 dehydrogenase activity
IUZ65_RS01565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IUZ65_RS01575	COG2895	sulfate adenylyltransferase (ATP) activity
IUZ65_RS01580	COG0471	metal ion transport
IUZ65_RS01580	COG3273	potassium ion transport
IUZ65_RS01585	COG0529	Catalyzes the synthesis of activated sulfate
IUZ65_RS01605	COG1136	(ABC) transporter
IUZ65_RS01620	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IUZ65_RS01630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IUZ65_RS01640	COG2911	Protein conserved in bacteria
IUZ65_RS01645	COG2105	PFAM AIG2 family protein
IUZ65_RS01660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IUZ65_RS01665	COG0163	prenyltransferase activity
IUZ65_RS01670	COG4143	(ABC) transporter
IUZ65_RS01675	COG1178	ABC-type Fe3 transport system permease component
IUZ65_RS01680	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IUZ65_RS01685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IUZ65_RS01705	COG2358	TRAP transporter, solute receptor (TAXI family
IUZ65_RS01710	COG1438	arginine binding
IUZ65_RS01715	COG0039	L-malate dehydrogenase activity
IUZ65_RS01725	COG0142	geranyltranstransferase activity
IUZ65_RS01740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IUZ65_RS01745	COG2966	Psort location CytoplasmicMembrane, score
IUZ65_RS01750	COG3610	response to peptide
IUZ65_RS01760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IUZ65_RS01770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IUZ65_RS01775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IUZ65_RS01785	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IUZ65_RS01800	COG0066	3-isopropylmalate dehydratase activity
IUZ65_RS01810	COG0473	3-isopropylmalate dehydrogenase activity
IUZ65_RS01840	COG1028	Short-chain dehydrogenase reductase Sdr
IUZ65_RS01860	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IUZ65_RS01890	COG3122	Protein conserved in bacteria
IUZ65_RS01895	COG2885	chlorophyll binding
IUZ65_RS01895	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IUZ65_RS01905	COG0583	DNA-binding transcription factor activity
IUZ65_RS01910	COG1280	lysine exporter protein (LysE YggA)
IUZ65_RS01915	COG0840	transmembrane signaling receptor activity
IUZ65_RS02000	COG0741	lytic transglycosylase activity
IUZ65_RS02005	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IUZ65_RS02015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IUZ65_RS02020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IUZ65_RS02025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IUZ65_RS02030	COG1872	DUF167
IUZ65_RS02035	COG0762	integral membrane protein
IUZ65_RS02040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IUZ65_RS02045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IUZ65_RS02060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IUZ65_RS02065	COG1678	Uncharacterized ACR, COG1678
IUZ65_RS02070	COG0189	ligase activity
IUZ65_RS02075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IUZ65_RS02090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IUZ65_RS02100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IUZ65_RS02105	COG0126	phosphoglycerate kinase activity
IUZ65_RS02110	COG0191	fructose-bisphosphate aldolase activity
IUZ65_RS02115	COG0668	transmembrane transport
IUZ65_RS02120	COG1279	arginine transmembrane transporter activity
IUZ65_RS02125	COG0583	DNA-binding transcription factor activity
IUZ65_RS02135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IUZ65_RS02140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IUZ65_RS02145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IUZ65_RS02155	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IUZ65_RS02160	COG3079	Belongs to the UPF0149 family
IUZ65_RS02165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUZ65_RS02170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUZ65_RS02185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IUZ65_RS02190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IUZ65_RS02195	COG1595	DNA-templated transcription, initiation
IUZ65_RS02200	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IUZ65_RS02205	COG3026	antisigma factor binding
IUZ65_RS02215	COG0481	GTPase activity
IUZ65_RS02225	COG0571	ribonuclease III activity
IUZ65_RS02230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IUZ65_RS02235	COG1381	Involved in DNA repair and RecF pathway recombination
IUZ65_RS02240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IUZ65_RS02250	COG2205	protein histidine kinase activity
IUZ65_RS02250	COG3437	response regulator, receiver
IUZ65_RS02250	COG3850	Histidine kinase
IUZ65_RS02250	COG4999	Histidine kinase
IUZ65_RS02255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IUZ65_RS02260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUZ65_RS02265	COG3956	TIGRFAM MazG family protein
IUZ65_RS02270	COG0504	CTP synthase activity
IUZ65_RS02275	COG0148	phosphopyruvate hydratase activity
IUZ65_RS02280	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IUZ65_RS02285	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IUZ65_RS02290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IUZ65_RS02295	COG0585	pseudouridine synthase activity
IUZ65_RS02305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IUZ65_RS02310	COG1388	LysM domain
IUZ65_RS02310	COG4942	peptidase
IUZ65_RS02315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IUZ65_RS02320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IUZ65_RS02325	COG1546	Belongs to the CinA family
IUZ65_RS02330	COG2860	membrane
IUZ65_RS02335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IUZ65_RS02355	COG0067	glutamate synthase
IUZ65_RS02355	COG0069	glutamate synthase activity
IUZ65_RS02355	COG0070	glutamate synthase
IUZ65_RS02360	COG1242	4 iron, 4 sulfur cluster binding
IUZ65_RS02365	COG2203	Gaf domain
IUZ65_RS02365	COG4251	negative regulation of phosphorylation
IUZ65_RS02365	COG3706	GGDEF domain
IUZ65_RS02365	COG5001	Diguanylate cyclase
IUZ65_RS02370	COG0784	Response regulator, receiver
IUZ65_RS02370	COG2198	Histidine kinase
IUZ65_RS02370	COG5002	protein histidine kinase activity
IUZ65_RS02375	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS02380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IUZ65_RS02395	COG0083	homoserine kinase activity
IUZ65_RS02400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IUZ65_RS02410	COG2807	transmembrane transport
IUZ65_RS02425	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IUZ65_RS02435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IUZ65_RS02450	COG1115	amino acid carrier protein
IUZ65_RS02455	COG3022	response to hydroperoxide
IUZ65_RS02460	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS02475	COG0716	FMN binding
IUZ65_RS02480	COG4974	Belongs to the 'phage' integrase family
IUZ65_RS02485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUZ65_RS02490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IUZ65_RS02500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IUZ65_RS02515	COG2207	Transcriptional regulator
IUZ65_RS02525	COG0004	ammonium transporteR
IUZ65_RS02530	COG1840	ABC-type Fe3 transport system, periplasmic component
IUZ65_RS02540	COG3842	ATPase activity
IUZ65_RS02545	COG0393	Putative heavy-metal-binding
IUZ65_RS02550	COG0393	Putative heavy-metal-binding
IUZ65_RS02555	COG4783	chaperone-mediated protein folding
IUZ65_RS02565	COG2971	BadF BadG BcrA BcrD
IUZ65_RS02575	COG4608	Belongs to the ABC transporter superfamily
IUZ65_RS02580	COG0444	Belongs to the ABC transporter superfamily
IUZ65_RS02585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IUZ65_RS02595	COG0747	negative chemotaxis
IUZ65_RS02600	COG2205	protein histidine kinase activity
IUZ65_RS02600	COG0784	Response regulator, receiver
IUZ65_RS02605	COG2813	Specifically methylates the guanine in position
IUZ65_RS02610	COG0628	permease
IUZ65_RS02615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IUZ65_RS02620	COG0316	Belongs to the HesB IscA family
IUZ65_RS02635	COG0739	heme binding
IUZ65_RS02645	COG0488	(ABC) transporter
IUZ65_RS02655	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IUZ65_RS02660	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IUZ65_RS02665	COG0077	Prephenate dehydratase
IUZ65_RS02665	COG1605	Chorismate mutase
IUZ65_RS02670	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IUZ65_RS02675	COG0741	lytic transglycosylase activity
IUZ65_RS02680	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUZ65_RS02685	COG0564	pseudouridine synthase activity
IUZ65_RS02690	COG1496	oxidoreductase activity
IUZ65_RS02695	COG0542	response to heat
IUZ65_RS02850	COG4974	Belongs to the 'phage' integrase family
IUZ65_RS02885	COG0840	transmembrane signaling receptor activity
IUZ65_RS02890	COG3706	GGDEF domain
IUZ65_RS02900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IUZ65_RS02905	COG0463	Glycosyl transferase, family 2
IUZ65_RS02910	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS02915	COG5002	protein histidine kinase activity
IUZ65_RS02920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IUZ65_RS02930	COG0826	peptidase U32
IUZ65_RS02935	COG2974	May be involved in recombination
IUZ65_RS02940	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS02945	COG5002	protein histidine kinase activity
IUZ65_RS02955	COG0248	Ppx GppA phosphatase
IUZ65_RS02960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IUZ65_RS02970	COG0581	inorganic phosphate transmembrane transporter activity
IUZ65_RS02975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IUZ65_RS02980	COG0704	Plays a role in the regulation of phosphate uptake
IUZ65_RS02995	COG1842	Phage shock protein A
IUZ65_RS03000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IUZ65_RS03020	COG0754	glutathionylspermidine amidase activity
IUZ65_RS03025	COG0450	alkyl hydroperoxide reductase
IUZ65_RS03030	COG0583	DNA-binding transcription factor activity
IUZ65_RS03050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IUZ65_RS03055	COG0517	IMP dehydrogenase activity
IUZ65_RS03060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IUZ65_RS03065	COG0343	queuine tRNA-ribosyltransferase activity
IUZ65_RS03070	COG1862	Preprotein translocase
IUZ65_RS03075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUZ65_RS03080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUZ65_RS03090	COG0456	acetyltransferase
IUZ65_RS03095	COG0483	inositol monophosphate 1-phosphatase activity
IUZ65_RS03100	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IUZ65_RS03105	COG1959	2 iron, 2 sulfur cluster binding
IUZ65_RS03110	COG1104	cysteine desulfurase activity
IUZ65_RS03115	COG0822	iron-sulfur transferase activity
IUZ65_RS03130	COG0443	Heat shock 70 kDa protein
IUZ65_RS03135	COG0633	Ferredoxin
IUZ65_RS03140	COG2975	iron-sulfur cluster assembly
IUZ65_RS03150	COG0105	UTP biosynthetic process
IUZ65_RS03170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IUZ65_RS03175	COG0124	histidyl-tRNA synthetase
IUZ65_RS03180	COG2976	Protein conserved in bacteria
IUZ65_RS03185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUZ65_RS03190	COG1160	GTP binding
IUZ65_RS03205	COG0517	IMP dehydrogenase activity
IUZ65_RS03205	COG0516	GMP reductase activity
IUZ65_RS03210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IUZ65_RS03210	COG0519	Catalyzes the synthesis of GMP from XMP
IUZ65_RS03215	COG1584	GPR1 FUN34 yaaH family protein
IUZ65_RS03230	COG1342	Belongs to the UPF0251 family
IUZ65_RS03265	COG1187	pseudouridine synthase activity
IUZ65_RS03290	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IUZ65_RS03305	COG0813	purine-nucleoside phosphorylase activity
IUZ65_RS03310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IUZ65_RS03315	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IUZ65_RS03355	COG3706	GGDEF domain
IUZ65_RS03400	COG0840	transmembrane signaling receptor activity
IUZ65_RS03410	COG2207	Transcriptional regulator
IUZ65_RS03420	COG3550	peptidyl-serine autophosphorylation
IUZ65_RS03425	COG1396	sequence-specific DNA binding
IUZ65_RS03475	COG2373	Large extracellular alpha-helical protein
IUZ65_RS03480	COG4953	penicillin-binding protein 1C
IUZ65_RS03490	COG2867	negative regulation of translational initiation
IUZ65_RS03495	COG2914	Belongs to the UPF0125 (RnfH) family
IUZ65_RS03500	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUZ65_RS03505	COG0497	DNA recombination
IUZ65_RS03515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IUZ65_RS03520	COG0443	Heat shock 70 kDa protein
IUZ65_RS03525	COG0484	heat shock protein binding
IUZ65_RS03550	COG0590	tRNA wobble adenosine to inosine editing
IUZ65_RS03560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IUZ65_RS03575	COG2195	Cleaves the N-terminal amino acid of tripeptides
IUZ65_RS03580	COG2252	PERMEase
IUZ65_RS03585	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IUZ65_RS03590	COG1073	alpha beta
IUZ65_RS03600	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IUZ65_RS03605	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IUZ65_RS03615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUZ65_RS03615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUZ65_RS03640	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IUZ65_RS03645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IUZ65_RS03650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IUZ65_RS03655	COG0142	geranyltranstransferase activity
IUZ65_RS03665	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IUZ65_RS03670	COG1360	Flagellar Motor Protein
IUZ65_RS03680	COG3290	protein histidine kinase activity
IUZ65_RS03685	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IUZ65_RS03690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUZ65_RS03690	COG0301	tRNA thio-modification
IUZ65_RS03695	COG0583	DNA-binding transcription factor activity
IUZ65_RS03700	COG2363	Small membrane protein
IUZ65_RS03710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IUZ65_RS03715	COG1611	Belongs to the LOG family
IUZ65_RS03730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IUZ65_RS03730	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IUZ65_RS03740	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
IUZ65_RS03745	COG1671	Belongs to the UPF0178 family
IUZ65_RS03765	COG3098	single-species biofilm formation
IUZ65_RS03770	COG0564	pseudouridine synthase activity
IUZ65_RS03775	COG1609	Transcriptional regulator
IUZ65_RS03785	COG0673	inositol 2-dehydrogenase activity
IUZ65_RS03790	COG1129	ABC transporter
IUZ65_RS03795	COG1172	Belongs to the binding-protein-dependent transport system permease family
IUZ65_RS03800	COG1879	ABC-type sugar transport system periplasmic component
IUZ65_RS03815	COG0024	Methionine aminopeptidase
IUZ65_RS03825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IUZ65_RS03830	COG0528	UMP kinase activity
IUZ65_RS03840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IUZ65_RS03845	COG0575	Belongs to the CDS family
IUZ65_RS03850	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IUZ65_RS03855	COG0750	zinc metalloprotease
IUZ65_RS03865	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IUZ65_RS03870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IUZ65_RS03875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IUZ65_RS03880	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IUZ65_RS03890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IUZ65_RS03895	COG0587	DNA-directed DNA polymerase activity
IUZ65_RS03900	COG0825	malonyl-CoA metabolic process
IUZ65_RS03915	COG0347	Belongs to the P(II) protein family
IUZ65_RS03930	COG0741	lytic transglycosylase activity
IUZ65_RS03930	COG1388	LysM domain
IUZ65_RS03935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IUZ65_RS03940	COG2226	methyltransferase
IUZ65_RS03945	COG0328	RNA-DNA hybrid ribonuclease activity
IUZ65_RS03950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUZ65_RS03960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IUZ65_RS03965	COG0121	glutamine amidotransferase
IUZ65_RS03970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IUZ65_RS03975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IUZ65_RS03980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IUZ65_RS03985	COG0133	tryptophan synthase activity
IUZ65_RS03990	COG2233	PERMEase
IUZ65_RS04005	COG1393	Belongs to the ArsC family
IUZ65_RS04010	COG4783	chaperone-mediated protein folding
IUZ65_RS04025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IUZ65_RS04035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IUZ65_RS04040	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IUZ65_RS04050	COG1876	peptidase activity
IUZ65_RS04060	COG1393	Belongs to the ArsC family
IUZ65_RS04090	COG2837	iron assimilation
IUZ65_RS04095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUZ65_RS04100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUZ65_RS04105	COG2190	(PTS) system
IUZ65_RS04115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS04120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IUZ65_RS04125	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IUZ65_RS04130	COG3115	cell septum assembly
IUZ65_RS04145	COG0789	Transcriptional regulator
IUZ65_RS04155	COG0330	HflC and HflK could
IUZ65_RS04160	COG3118	belongs to the thioredoxin family
IUZ65_RS04165	COG0300	oxidoreductase activity
IUZ65_RS04170	COG1090	epimerase
IUZ65_RS04195	COG0622	Phosphoesterase
IUZ65_RS04205	COG3710	Transcriptional regulator
IUZ65_RS04210	COG0326	Molecular chaperone. Has ATPase activity
IUZ65_RS04220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IUZ65_RS04230	COG0367	asparagine synthase
IUZ65_RS04235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IUZ65_RS04235	COG4651	solute:proton antiporter activity
IUZ65_RS04240	COG1846	Transcriptional regulator
IUZ65_RS04240	COG1940	carbohydrate kinase activity
IUZ65_RS04245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IUZ65_RS04250	COG0363	glucosamine-6-phosphate deaminase activity
IUZ65_RS04255	COG1263	PTS System
IUZ65_RS04255	COG2190	(PTS) system
IUZ65_RS04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IUZ65_RS04260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IUZ65_RS04265	COG0735	belongs to the Fur family
IUZ65_RS04275	COG0716	FMN binding
IUZ65_RS04285	COG0596	Alpha beta hydrolase
IUZ65_RS04290	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IUZ65_RS04295	COG0033	Phosphoglucomutase
IUZ65_RS04305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IUZ65_RS04320	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IUZ65_RS04325	COG1053	succinate dehydrogenase
IUZ65_RS04330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IUZ65_RS04335	COG0567	Dehydrogenase, E1 component
IUZ65_RS04340	COG0508	dehydrogenase complex catalyzes the overall conversion of
IUZ65_RS04345	COG0045	succinate-CoA ligase (ADP-forming) activity
IUZ65_RS04350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IUZ65_RS04360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IUZ65_RS04370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IUZ65_RS04375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IUZ65_RS04380	COG2056	Na+-H+ antiporter family
IUZ65_RS04385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUZ65_RS04395	COG0788	formyltetrahydrofolate deformylase activity
IUZ65_RS04405	COG1199	ATP-dependent helicase activity
IUZ65_RS04410	COG1214	PFAM Peptidase M22, glycoprotease
IUZ65_RS04420	COG3065	identical protein binding
IUZ65_RS04430	COG0318	PFAM AMP-dependent synthetase and ligase
IUZ65_RS04435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IUZ65_RS04440	COG3100	YcgL domain-containing protein
IUZ65_RS04445	COG2951	lytic endotransglycosylase activity
IUZ65_RS04450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IUZ65_RS04460	COG3706	GGDEF domain
IUZ65_RS04465	COG0110	maltose O-acetyltransferase activity
IUZ65_RS04470	COG0840	transmembrane signaling receptor activity
IUZ65_RS04475	COG0583	DNA-binding transcription factor activity
IUZ65_RS04480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IUZ65_RS04485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IUZ65_RS04490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IUZ65_RS04515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IUZ65_RS04520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IUZ65_RS04525	COG0776	regulation of translation
IUZ65_RS04530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IUZ65_RS04535	COG1555	photosystem II stabilization
IUZ65_RS04550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IUZ65_RS04555	COG2115	Belongs to the xylose isomerase family
IUZ65_RS04560	COG4213	ABC transporter substrate-binding protein
IUZ65_RS04565	COG1129	ABC transporter
IUZ65_RS04570	COG4214	carbohydrate transport
IUZ65_RS04575	COG2207	Transcriptional regulator
IUZ65_RS04575	COG1609	Transcriptional regulator
IUZ65_RS04580	COG1070	Carbohydrate kinase
IUZ65_RS04590	COG4221	oxidoreductase activity
IUZ65_RS04605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IUZ65_RS04610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IUZ65_RS04610	COG1648	precorrin-2 dehydrogenase activity
IUZ65_RS04615	COG0243	molybdopterin cofactor binding
IUZ65_RS04625	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IUZ65_RS04630	COG0436	Aminotransferase
IUZ65_RS04635	COG1169	isochorismate synthase
IUZ65_RS04640	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IUZ65_RS04650	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IUZ65_RS04670	COG2855	membrane
IUZ65_RS04690	COG0280	phosphate acetyltransferase
IUZ65_RS04690	COG0857	belongs to the CobB CobQ family
IUZ65_RS04695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IUZ65_RS04710	COG4120	Belongs to the binding-protein-dependent transport system permease family
IUZ65_RS04715	COG1122	ATPase activity
IUZ65_RS04720	COG0366	Alpha amylase catalytic
IUZ65_RS04725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IUZ65_RS04730	COG0653	protein targeting
IUZ65_RS04735	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IUZ65_RS04740	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IUZ65_RS04745	COG2186	Transcriptional regulator
IUZ65_RS04750	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IUZ65_RS04780	COG3713	MltA-interacting MipA family protein
IUZ65_RS04790	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS04815	COG3547	Transposase (IS116 IS110 IS902 family)
IUZ65_RS04850	COG2169	Transcriptional regulator
IUZ65_RS04850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IUZ65_RS04855	COG0584	glycerophosphoryl diester phosphodiesterase
IUZ65_RS04870	COG4335	DNA alkylation repair
IUZ65_RS04885	COG0583	DNA-binding transcription factor activity
IUZ65_RS04915	COG0400	carboxylic ester hydrolase activity
IUZ65_RS04930	COG0154	amidase activity
IUZ65_RS04940	COG1280	lysine exporter protein (LysE YggA)
IUZ65_RS04975	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
IUZ65_RS04995	COG0583	DNA-binding transcription factor activity
IUZ65_RS05000	COG0730	response to heat
IUZ65_RS05005	COG2258	MOSC domain
IUZ65_RS05020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IUZ65_RS05070	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IUZ65_RS05125	COG0363	glucosamine-6-phosphate deaminase activity
IUZ65_RS05135	COG2205	protein histidine kinase activity
IUZ65_RS05140	COG1653	transport
IUZ65_RS05165	COG4895	conserved protein (DUF2196)
IUZ65_RS05170	COG1902	pentaerythritol trinitrate reductase activity
IUZ65_RS05175	COG0583	DNA-binding transcription factor activity
IUZ65_RS05180	COG2207	Transcriptional regulator
IUZ65_RS05180	COG3708	Transcriptional regulator
IUZ65_RS05205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IUZ65_RS05205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IUZ65_RS05215	COG0572	uridine kinase
IUZ65_RS05220	COG2982	Protein involved in outer membrane biogenesis
IUZ65_RS05225	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IUZ65_RS05230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IUZ65_RS05235	COG0659	secondary active sulfate transmembrane transporter activity
IUZ65_RS05245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IUZ65_RS05250	COG4558	Periplasmic binding protein
IUZ65_RS05255	COG0848	biopolymer transport protein
IUZ65_RS05260	COG0811	peptide transport
IUZ65_RS05265	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IUZ65_RS05275	COG3721	Heme iron utilization protein
IUZ65_RS05280	COG0748	coenzyme F420 binding
IUZ65_RS05290	COG1132	(ABC) transporter
IUZ65_RS05295	COG1530	ribonuclease E activity
IUZ65_RS05300	COG0564	pseudouridine synthase activity
IUZ65_RS05305	COG0424	maF-like protein
IUZ65_RS05310	COG1399	metal-binding, possibly nucleic acid-binding protein
IUZ65_RS05315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IUZ65_RS05325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IUZ65_RS05330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IUZ65_RS05345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IUZ65_RS05355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IUZ65_RS05360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IUZ65_RS05370	COG0084	hydrolase, TatD family'
IUZ65_RS05375	COG1263	PTS System
IUZ65_RS05375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IUZ65_RS05390	COG0733	neurotransmitter:sodium symporter activity
IUZ65_RS05400	COG4667	esterase of the alpha-beta hydrolase superfamily
IUZ65_RS05405	COG0469	pyruvate kinase activity
IUZ65_RS05410	COG1940	carbohydrate kinase activity
IUZ65_RS05415	COG0784	Response regulator, receiver
IUZ65_RS05415	COG0835	chemotaxis
IUZ65_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
IUZ65_RS05445	COG0616	signal peptide processing
IUZ65_RS05455	COG0539	negative regulation of cytoplasmic translation
IUZ65_RS05465	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IUZ65_RS05470	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IUZ65_RS05475	COG0284	orotidine-5'-phosphate decarboxylase activity
IUZ65_RS05495	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS05500	COG3716	PTS system mannose fructose sorbose family IID component
IUZ65_RS05505	COG3715	PTS system
IUZ65_RS05510	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IUZ65_RS05515	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IUZ65_RS05520	COG5492	domain, Protein
IUZ65_RS05530	COG0583	DNA-binding transcription factor activity
IUZ65_RS05540	COG0686	Belongs to the AlaDH PNT family
IUZ65_RS05545	COG1522	sequence-specific DNA binding
IUZ65_RS05560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IUZ65_RS05565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IUZ65_RS05575	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IUZ65_RS05580	COG0156	8-amino-7-oxononanoate synthase activity
IUZ65_RS05585	COG2226	methyltransferase
IUZ65_RS05590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IUZ65_RS05600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IUZ65_RS05620	COG1012	belongs to the aldehyde dehydrogenase family
IUZ65_RS05630	COG0667	Aldo Keto reductase
IUZ65_RS05645	COG1902	pentaerythritol trinitrate reductase activity
IUZ65_RS05655	COG0789	Transcriptional regulator
IUZ65_RS05665	COG3119	arylsulfatase activity
IUZ65_RS05670	COG3181	Tripartite tricarboxylate transporter family receptor
IUZ65_RS05700	COG1741	Belongs to the pirin family
IUZ65_RS05705	COG0435	Glutathione S-transferase
IUZ65_RS05710	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IUZ65_RS05730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IUZ65_RS05730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IUZ65_RS05735	COG2313	pseudouridylate synthase activity
IUZ65_RS05740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUZ65_RS05740	COG1522	sequence-specific DNA binding
IUZ65_RS05745	COG0583	DNA-binding transcription factor activity
IUZ65_RS05770	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IUZ65_RS05780	COG0583	DNA-binding transcription factor activity
IUZ65_RS05810	COG0493	'glutamate synthase
IUZ65_RS05815	COG0674	pyruvate-flavodoxin oxidoreductase activity
IUZ65_RS05815	COG1013	pyruvate-flavodoxin oxidoreductase activity
IUZ65_RS05815	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IUZ65_RS05815	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IUZ65_RS05845	COG3909	cytochrome
IUZ65_RS05860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IUZ65_RS05865	COG0784	Response regulator, receiver
IUZ65_RS05865	COG3437	response regulator, receiver
IUZ65_RS05875	COG1309	transcriptional regulator
IUZ65_RS05885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IUZ65_RS05895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IUZ65_RS05895	COG1116	anion transmembrane transporter activity
IUZ65_RS05900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IUZ65_RS05905	COG1116	anion transmembrane transporter activity
IUZ65_RS05910	COG4580	involved in the transport of maltose and maltodextrins
IUZ65_RS05925	COG1175	transmembrane transport
IUZ65_RS05930	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS05940	COG3459	Glycosyltransferase 36 associated
IUZ65_RS05955	COG0840	transmembrane signaling receptor activity
IUZ65_RS05960	COG0517	IMP dehydrogenase activity
IUZ65_RS05960	COG0617	tRNA 3'-terminal CCA addition
IUZ65_RS05960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IUZ65_RS05970	COG0471	metal ion transport
IUZ65_RS05975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUZ65_RS05975	COG4191	Histidine kinase
IUZ65_RS05985	COG2217	Heavy metal translocating P-type atpase
IUZ65_RS05990	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IUZ65_RS06005	COG0537	adenosine 5'-monophosphoramidase activity
IUZ65_RS06030	COG3150	esterase
IUZ65_RS06035	COG1252	NADH dehydrogenase
IUZ65_RS06050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IUZ65_RS06060	COG4591	ABC-type transport system involved in lipoprotein release permease component
IUZ65_RS06070	COG2358	TRAP transporter, solute receptor (TAXI family
IUZ65_RS06075	COG1136	(ABC) transporter
IUZ65_RS06080	COG4591	ABC-type transport system involved in lipoprotein release permease component
IUZ65_RS06090	COG0658	competence protein
IUZ65_RS06090	COG2333	competence protein COMEC
IUZ65_RS06095	COG1132	(ABC) transporter
IUZ65_RS06115	COG2719	SpoVR family
IUZ65_RS06120	COG2718	Belongs to the UPF0229 family
IUZ65_RS06125	COG2766	serine protein kinase
IUZ65_RS06130	COG3713	MltA-interacting MipA family protein
IUZ65_RS06135	COG4810	utilization protein
IUZ65_RS06150	COG4812	Cobalamin adenosyltransferase
IUZ65_RS06155	COG0280	phosphate acetyltransferase
IUZ65_RS06165	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IUZ65_RS06170	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IUZ65_RS06185	COG1454	alcohol dehydrogenase
IUZ65_RS06205	COG4816	utilization protein
IUZ65_RS06210	COG4656	Part of a membrane complex involved in electron transport
IUZ65_RS06220	COG0531	amino acid
IUZ65_RS06225	COG3013	Belongs to the UPF0304 family
IUZ65_RS06230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IUZ65_RS06245	COG1882	Formate acetyltransferase
IUZ65_RS06265	COG4215	(ABC) transporter
IUZ65_RS06270	COG4160	amino acid transport
IUZ65_RS06275	COG0708	Exodeoxyribonuclease III
IUZ65_RS06285	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IUZ65_RS06300	COG3706	GGDEF domain
IUZ65_RS06310	COG0840	transmembrane signaling receptor activity
IUZ65_RS06320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IUZ65_RS06330	COG0482	sulfurtransferase activity
IUZ65_RS06350	COG1278	Cold shock
IUZ65_RS06355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IUZ65_RS06360	COG0542	response to heat
IUZ65_RS06365	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IUZ65_RS06370	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IUZ65_RS06375	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IUZ65_RS06380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IUZ65_RS06390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IUZ65_RS06395	COG0297	glycogen (starch) synthase activity
IUZ65_RS06415	COG3070	regulator of competence-specific genes
IUZ65_RS06420	COG1609	Transcriptional regulator
IUZ65_RS06425	COG3381	protein complex oligomerization
IUZ65_RS06430	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS06435	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IUZ65_RS06445	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
IUZ65_RS06450	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IUZ65_RS06455	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IUZ65_RS06460	COG1403	HNH endonuclease
IUZ65_RS06470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUZ65_RS06480	COG0390	transport system, permease component
IUZ65_RS06485	COG4459	periplasmic nitrate reductase
IUZ65_RS06490	COG3005	denitrification pathway
IUZ65_RS06500	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IUZ65_RS06505	COG1227	inorganic diphosphatase activity
IUZ65_RS06515	COG4172	Belongs to the ABC transporter superfamily
IUZ65_RS06525	COG4171	peptide transport system, permease
IUZ65_RS06530	COG4168	peptide transport system, permease
IUZ65_RS06540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IUZ65_RS06545	COG1842	Phage shock protein A
IUZ65_RS06575	COG0519	Catalyzes the synthesis of GMP from XMP
IUZ65_RS06590	COG0626	cystathionine gamma-synthase activity
IUZ65_RS06600	COG0733	neurotransmitter:sodium symporter activity
IUZ65_RS06605	COG0564	pseudouridine synthase activity
IUZ65_RS06610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IUZ65_RS06610	COG0116	Belongs to the methyltransferase superfamily
IUZ65_RS06615	COG2195	Cleaves the N-terminal amino acid of tripeptides
IUZ65_RS06620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IUZ65_RS06625	COG4136	ATPase activity
IUZ65_RS06630	COG4135	transport system, permease component
IUZ65_RS06635	COG4134	Bacterial extracellular solute-binding protein
IUZ65_RS06645	COG2350	Protein conserved in bacteria
IUZ65_RS06655	COG2917	probably involved in intracellular septation
IUZ65_RS06660	COG0159	tryptophan synthase activity
IUZ65_RS06665	COG0133	tryptophan synthase activity
IUZ65_RS06670	COG0135	phosphoribosylanthranilate isomerase activity
IUZ65_RS06670	COG0134	indole-3-glycerol-phosphate synthase activity
IUZ65_RS06675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IUZ65_RS06680	COG0512	Glutamine amidotransferase of anthranilate synthase
IUZ65_RS06685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IUZ65_RS06690	COG0613	PHP domain protein
IUZ65_RS06695	COG0009	L-threonylcarbamoyladenylate synthase
IUZ65_RS06700	COG1187	pseudouridine synthase activity
IUZ65_RS06720	COG0417	DNA replication proofreading
IUZ65_RS06725	COG2197	response regulator
IUZ65_RS06730	COG0322	excinuclease ABC activity
IUZ65_RS06770	COG2207	Transcriptional regulator
IUZ65_RS06775	COG1979	alcohol dehydrogenase
IUZ65_RS06825	COG0583	DNA-binding transcription factor activity
IUZ65_RS06835	COG1139	Iron-sulfur cluster binding protein
IUZ65_RS06865	COG4221	oxidoreductase activity
IUZ65_RS06870	COG5001	Diguanylate cyclase
IUZ65_RS06890	COG0019	diaminopimelate decarboxylase activity
IUZ65_RS06905	COG1546	Belongs to the CinA family
IUZ65_RS06905	COG1058	Belongs to the CinA family
IUZ65_RS06925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUZ65_RS06930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IUZ65_RS06950	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IUZ65_RS06960	COG0437	4 iron, 4 sulfur cluster binding
IUZ65_RS06965	COG3301	Polysulphide reductase, NrfD
IUZ65_RS06970	COG1138	Cytochrome C-type biogenesis protein
IUZ65_RS06975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IUZ65_RS06980	COG3088	subunit of a heme lyase
IUZ65_RS06980	COG4235	cytochrome complex assembly
IUZ65_RS06985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IUZ65_RS06995	COG3108	Peptidase M15
IUZ65_RS07000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IUZ65_RS07010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IUZ65_RS07035	COG1448	Aminotransferase
IUZ65_RS07040	COG2770	Histidine kinase
IUZ65_RS07040	COG3437	response regulator, receiver
IUZ65_RS07045	COG0017	Asparaginyl-tRNA synthetase
IUZ65_RS07055	COG0494	nUDIX hydrolase
IUZ65_RS07075	COG3106	COG3106 Predicted ATPase
IUZ65_RS07080	COG3768	UPF0283 membrane protein
IUZ65_RS07090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IUZ65_RS07125	COG1643	Atp-dependent helicase
IUZ65_RS07135	COG2358	TRAP transporter, solute receptor (TAXI family
IUZ65_RS07140	COG3246	L-lysine catabolic process to acetate
IUZ65_RS07145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IUZ65_RS07155	COG1032	radical SAM domain protein
IUZ65_RS07180	COG3313	Fe-S protein
IUZ65_RS07185	COG2957	Belongs to the agmatine deiminase family
IUZ65_RS07190	COG0531	amino acid
IUZ65_RS07195	COG0549	Belongs to the carbamate kinase family
IUZ65_RS07200	COG1309	transcriptional regulator
IUZ65_RS07220	COG2259	Doxx family
IUZ65_RS07225	COG3384	dioxygenase
IUZ65_RS07240	COG3437	response regulator, receiver
IUZ65_RS07265	COG3300	MHYT domain
IUZ65_RS07265	COG5001	Diguanylate cyclase
IUZ65_RS07270	COG0786	glutamate:sodium symporter activity
IUZ65_RS07290	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IUZ65_RS07300	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IUZ65_RS07305	COG0583	DNA-binding transcription factor activity
IUZ65_RS07335	COG3069	C4-dicarboxylate transmembrane transporter activity
IUZ65_RS07355	COG2070	2-Nitropropane dioxygenase
IUZ65_RS07355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IUZ65_RS07370	COG1175	transmembrane transport
IUZ65_RS07375	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS07380	COG0165	Argininosuccinate lyase
IUZ65_RS07385	COG3842	ATPase activity
IUZ65_RS07395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IUZ65_RS07400	COG2971	BadF BadG BcrA BcrD
IUZ65_RS07415	COG0814	amino acid
IUZ65_RS07430	COG0814	amino acid
IUZ65_RS07435	COG1177	transmembrane transport
IUZ65_RS07440	COG1176	ABC-type spermidine putrescine transport system, permease component I
IUZ65_RS07445	COG3842	ATPase activity
IUZ65_RS07465	COG0583	DNA-binding transcription factor activity
IUZ65_RS07470	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IUZ65_RS07485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IUZ65_RS07490	COG1061	Type III restriction enzyme res subunit
IUZ65_RS07500	COG2814	Major facilitator Superfamily
IUZ65_RS07510	COG0702	epimerase
IUZ65_RS07515	COG0534	Mate efflux family protein
IUZ65_RS07520	COG1136	(ABC) transporter
IUZ65_RS07525	COG0577	efflux transmembrane transporter activity
IUZ65_RS07535	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IUZ65_RS07540	COG1309	transcriptional regulator
IUZ65_RS07550	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IUZ65_RS07560	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IUZ65_RS07565	COG1454	alcohol dehydrogenase
IUZ65_RS07570	COG1737	Transcriptional regulator
IUZ65_RS07575	COG0076	glutamate decarboxylase activity
IUZ65_RS07585	COG2431	L-lysine efflux transmembrane transporter activity
IUZ65_RS07595	COG3070	regulator of competence-specific genes
IUZ65_RS07600	COG4174	ABC transporter (Permease)
IUZ65_RS07605	COG4239	(ABC) transporter, permease
IUZ65_RS07610	COG4166	transmembrane transport
IUZ65_RS07615	COG0444	Belongs to the ABC transporter superfamily
IUZ65_RS07620	COG4608	Belongs to the ABC transporter superfamily
IUZ65_RS07635	COG4191	Histidine kinase
IUZ65_RS07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUZ65_RS07645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IUZ65_RS07650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IUZ65_RS07655	COG4988	ABC transporter
IUZ65_RS07660	COG0492	ferredoxin-NADP+ reductase activity
IUZ65_RS07665	COG0471	metal ion transport
IUZ65_RS07670	COG2949	membrane
IUZ65_RS07680	COG1643	Atp-dependent helicase
IUZ65_RS07690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IUZ65_RS07720	COG0277	FAD linked oxidase domain protein
IUZ65_RS07720	COG0247	lactate metabolic process
IUZ65_RS07755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IUZ65_RS07760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IUZ65_RS07770	COG3706	GGDEF domain
IUZ65_RS07775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IUZ65_RS07780	COG0072	phenylalanine-tRNA ligase activity
IUZ65_RS07780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IUZ65_RS07785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IUZ65_RS07790	COG0776	regulation of translation
IUZ65_RS07800	COG0500	methyltransferase
IUZ65_RS07805	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IUZ65_RS07810	COG0295	cytidine deaminase activity
IUZ65_RS07815	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS07820	COG1346	cytolysis
IUZ65_RS07825	COG1380	Effector of murein hydrolase LrgA
IUZ65_RS07830	COG2925	Exonuclease
IUZ65_RS07840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IUZ65_RS07845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IUZ65_RS07860	COG2315	Protein conserved in bacteria
IUZ65_RS07870	COG1451	nucleotide metabolic process
IUZ65_RS07890	COG3842	ATPase activity
IUZ65_RS07895	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS07905	COG1653	transport
IUZ65_RS07915	COG2199	diguanylate cyclase activity
IUZ65_RS07915	COG2203	Gaf domain
IUZ65_RS07920	COG0668	transmembrane transport
IUZ65_RS07930	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IUZ65_RS07950	COG0739	heme binding
IUZ65_RS07955	COG0534	Mate efflux family protein
IUZ65_RS07960	COG0307	riboflavin synthase, alpha
IUZ65_RS07965	COG3001	Fructosamine kinase
IUZ65_RS07975	COG0791	NLP P60 protein
IUZ65_RS07980	COG2885	chlorophyll binding
IUZ65_RS08000	COG1254	Belongs to the acylphosphatase family
IUZ65_RS08005	COG2920	part of a sulfur-relay system
IUZ65_RS08010	COG0670	Belongs to the BI1 family
IUZ65_RS08015	COG1126	abc transporter atp-binding protein
IUZ65_RS08020	COG0765	amino acid transport
IUZ65_RS08025	COG4597	amino acid ABC transporter
IUZ65_RS08030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUZ65_RS08040	COG1666	GTP binding
IUZ65_RS08045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IUZ65_RS08050	COG0574	Belongs to the PEP-utilizing enzyme family
IUZ65_RS08050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IUZ65_RS08065	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IUZ65_RS08065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IUZ65_RS08070	COG3008	intermembrane lipid transfer
IUZ65_RS08075	COG2995	paraquat-inducible protein a
IUZ65_RS08080	COG1956	GAF domain-containing protein
IUZ65_RS08085	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IUZ65_RS08090	COG0793	Belongs to the peptidase S41A family
IUZ65_RS08100	COG0308	aminopeptidase N
IUZ65_RS08115	COG0167	dihydroorotate dehydrogenase activity
IUZ65_RS08135	COG0488	(ABC) transporter
IUZ65_RS08150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IUZ65_RS08155	COG1067	ATP-dependent peptidase activity
IUZ65_RS08160	COG3120	sequence-specific DNA binding
IUZ65_RS08170	COG3706	GGDEF domain
IUZ65_RS08180	COG3706	GGDEF domain
IUZ65_RS08205	COG2133	pyrroloquinoline quinone binding
IUZ65_RS08210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUZ65_RS08215	COG0653	protein targeting
IUZ65_RS08235	COG3278	Belongs to the heme-copper respiratory oxidase family
IUZ65_RS08250	COG2010	Cytochrome c
IUZ65_RS08260	COG2217	Heavy metal translocating P-type atpase
IUZ65_RS08275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IUZ65_RS08280	COG0589	response to stress
IUZ65_RS08305	COG3842	ATPase activity
IUZ65_RS08315	COG1177	transmembrane transport
IUZ65_RS08320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IUZ65_RS08325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IUZ65_RS08330	COG0004	ammonium transporteR
IUZ65_RS08335	COG3852	Histidine kinase
IUZ65_RS08365	COG1940	carbohydrate kinase activity
IUZ65_RS08370	COG3148	PFAM DTW domain containing protein
IUZ65_RS08395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IUZ65_RS08400	COG0561	phosphatase activity
IUZ65_RS08425	COG0372	Belongs to the citrate synthase family
IUZ65_RS08430	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IUZ65_RS08435	COG1802	Transcriptional regulator
IUZ65_RS08450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUZ65_RS08475	COG1115	amino acid carrier protein
IUZ65_RS08480	COG1280	lysine exporter protein (LysE YggA)
IUZ65_RS08490	COG4115	mRNA cleavage
IUZ65_RS08495	COG2161	toxin-antitoxin pair type II binding
IUZ65_RS08565	COG2252	PERMEase
IUZ65_RS08575	COG5642	Protein of unknown function (DUF2384)
IUZ65_RS08585	COG0494	nUDIX hydrolase
IUZ65_RS08610	COG0573	inorganic phosphate transmembrane transporter activity
IUZ65_RS08615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IUZ65_RS08620	COG3706	GGDEF domain
IUZ65_RS08620	COG2203	Gaf domain
IUZ65_RS08620	COG5001	Diguanylate cyclase
IUZ65_RS08620	COG4251	negative regulation of phosphorylation
IUZ65_RS08645	COG1275	C4-dicarboxylate transporter malic acid transport protein
IUZ65_RS08650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IUZ65_RS08655	COG1882	Formate acetyltransferase
IUZ65_RS08700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IUZ65_RS08710	COG0693	protein deglycase activity
IUZ65_RS08715	COG0840	transmembrane signaling receptor activity
IUZ65_RS08725	COG0488	(ABC) transporter
IUZ65_RS08730	COG1410	methionine synthase
IUZ65_RS08730	COG0646	methionine synthase
IUZ65_RS08750	COG3119	arylsulfatase activity
IUZ65_RS08770	COG5001	Diguanylate cyclase
IUZ65_RS08770	COG3300	MHYT domain
IUZ65_RS08785	COG0583	DNA-binding transcription factor activity
IUZ65_RS08795	COG1902	pentaerythritol trinitrate reductase activity
IUZ65_RS08830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IUZ65_RS08840	COG4807	Protein conserved in bacteria
IUZ65_RS08845	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS08850	COG1940	carbohydrate kinase activity
IUZ65_RS08855	COG1012	belongs to the aldehyde dehydrogenase family
IUZ65_RS08860	COG3284	Transcriptional regulator
IUZ65_RS08865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IUZ65_RS08870	COG0583	DNA-binding transcription factor activity
IUZ65_RS08890	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IUZ65_RS08925	COG3279	Response regulator of the LytR AlgR family
IUZ65_RS08930	COG3275	phosphorelay sensor kinase activity
IUZ65_RS08945	COG0577	efflux transmembrane transporter activity
IUZ65_RS08950	COG0577	efflux transmembrane transporter activity
IUZ65_RS08950	COG1136	(ABC) transporter
IUZ65_RS08995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IUZ65_RS09000	COG0730	response to heat
IUZ65_RS09010	COG0154	amidase activity
IUZ65_RS09020	COG1309	transcriptional regulator
IUZ65_RS09025	COG3845	ABC transporter
IUZ65_RS09060	COG0402	S-adenosylhomocysteine deaminase activity
IUZ65_RS09070	COG0583	DNA-binding transcription factor activity
IUZ65_RS09080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUZ65_RS09100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IUZ65_RS09125	COG2205	protein histidine kinase activity
IUZ65_RS09130	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS09175	COG0564	pseudouridine synthase activity
IUZ65_RS09180	COG3134	Outer membrane lipoprotein
IUZ65_RS09215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IUZ65_RS09235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IUZ65_RS09240	COG0521	Mo-molybdopterin cofactor biosynthetic process
IUZ65_RS09255	COG4865	methylaspartate mutase activity
IUZ65_RS09280	COG2119	membrane
IUZ65_RS09315	COG3037	sugar-specific permease SgaT UlaA
IUZ65_RS09330	COG0438	transferase activity, transferring glycosyl groups
IUZ65_RS09335	COG0366	Alpha amylase catalytic
IUZ65_RS09350	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS09355	COG3842	ATPase activity
IUZ65_RS09365	COG1609	Transcriptional regulator
IUZ65_RS09385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IUZ65_RS09405	COG0747	negative chemotaxis
IUZ65_RS09420	COG4172	Belongs to the ABC transporter superfamily
IUZ65_RS09430	COG1609	Transcriptional regulator
IUZ65_RS09440	COG0477	Major facilitator Superfamily
IUZ65_RS09455	COG0346	lactoylglutathione lyase activity
IUZ65_RS09465	COG0738	Major facilitator superfamily
IUZ65_RS09480	COG3152	Membrane
IUZ65_RS09490	COG0697	spore germination
IUZ65_RS09515	COG0741	lytic transglycosylase activity
IUZ65_RS09555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IUZ65_RS09565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUZ65_RS09570	COG1454	alcohol dehydrogenase
IUZ65_RS09580	COG0561	phosphatase activity
IUZ65_RS09590	COG0840	transmembrane signaling receptor activity
IUZ65_RS09675	COG0778	Nitroreductase
IUZ65_RS09680	COG1741	Belongs to the pirin family
IUZ65_RS09690	COG0583	DNA-binding transcription factor activity
IUZ65_RS09695	COG0583	DNA-binding transcription factor activity
IUZ65_RS09715	COG3539	Fimbrial protein
IUZ65_RS09720	COG3121	Chaperone
IUZ65_RS09725	COG3188	usher protein
IUZ65_RS09750	COG3539	Fimbrial protein
IUZ65_RS09765	COG2207	Transcriptional regulator
IUZ65_RS09770	COG1349	DNA-binding transcription factor activity
IUZ65_RS09785	COG3842	ATPase activity
IUZ65_RS09790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IUZ65_RS09810	COG0583	DNA-binding transcription factor activity
IUZ65_RS09820	COG0789	Transcriptional regulator
IUZ65_RS09830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IUZ65_RS09840	COG0583	DNA-binding transcription factor activity
IUZ65_RS09855	COG0583	DNA-binding transcription factor activity
IUZ65_RS09865	COG0583	DNA-binding transcription factor activity
IUZ65_RS09880	COG1737	Transcriptional regulator
IUZ65_RS09885	COG1263	PTS System
IUZ65_RS09885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IUZ65_RS09885	COG2190	(PTS) system
IUZ65_RS09890	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IUZ65_RS09905	COG0589	response to stress
IUZ65_RS09935	COG0402	S-adenosylhomocysteine deaminase activity
IUZ65_RS09940	COG2188	Transcriptional regulator
IUZ65_RS09945	COG2986	histidine ammonia-lyase
IUZ65_RS09950	COG1228	amidohydrolase
IUZ65_RS09960	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IUZ65_RS09965	COG1595	DNA-templated transcription, initiation
IUZ65_RS09975	COG1940	carbohydrate kinase activity
IUZ65_RS09980	COG1172	Belongs to the binding-protein-dependent transport system permease family
IUZ65_RS09985	COG1129	ABC transporter
IUZ65_RS09995	COG0457	Tetratricopeptide repeat
IUZ65_RS10005	COG0598	Magnesium transport protein CorA
IUZ65_RS10015	COG1785	Belongs to the alkaline phosphatase family
IUZ65_RS10035	COG1454	alcohol dehydrogenase
IUZ65_RS10045	COG3279	Response regulator of the LytR AlgR family
IUZ65_RS10055	COG2211	Major facilitator Superfamily
IUZ65_RS10060	COG1397	ADP-ribosylglycohydrolase
IUZ65_RS10065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUZ65_RS10070	COG2223	nitrite transmembrane transporter activity
IUZ65_RS10075	COG2188	Transcriptional regulator
IUZ65_RS10095	COG2207	Transcriptional regulator
IUZ65_RS10120	COG2195	Cleaves the N-terminal amino acid of tripeptides
IUZ65_RS10130	COG0577	efflux transmembrane transporter activity
IUZ65_RS10135	COG1136	(ABC) transporter
IUZ65_RS10150	COG4977	sequence-specific DNA binding
IUZ65_RS10160	COG1522	sequence-specific DNA binding
IUZ65_RS10175	COG0840	transmembrane signaling receptor activity
IUZ65_RS10190	COG0446	pyridine nucleotide-disulphide oxidoreductase
IUZ65_RS10190	COG1902	pentaerythritol trinitrate reductase activity
IUZ65_RS10195	COG1024	Enoyl-CoA hydratase
IUZ65_RS10195	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUZ65_RS10205	COG0183	Belongs to the thiolase family
IUZ65_RS10215	COG0427	acetyl-CoA hydrolase
IUZ65_RS10225	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IUZ65_RS10260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IUZ65_RS10265	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS10270	COG1175	transmembrane transport
IUZ65_RS10280	COG3842	ATPase activity
IUZ65_RS10290	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IUZ65_RS10300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IUZ65_RS10320	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IUZ65_RS10330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IUZ65_RS10350	COG0494	nUDIX hydrolase
IUZ65_RS10420	COG4245	von Willebrand factor, type A
IUZ65_RS10455	COG2003	Belongs to the UPF0758 family
IUZ65_RS10480	COG0582	viral genome integration into host DNA
IUZ65_RS10490	COG2197	response regulator
IUZ65_RS10495	COG3851	Histidine kinase
IUZ65_RS10500	COG2271	Major facilitator Superfamily
IUZ65_RS10505	COG1840	ABC-type Fe3 transport system, periplasmic component
IUZ65_RS10515	COG3842	ATPase activity
IUZ65_RS10535	COG1131	(ABC) transporter
IUZ65_RS10550	COG0330	HflC and HflK could
IUZ65_RS10555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IUZ65_RS10565	COG0247	lactate metabolic process
IUZ65_RS10570	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
IUZ65_RS10575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IUZ65_RS10580	COG2271	Major facilitator Superfamily
IUZ65_RS10585	COG1349	DNA-binding transcription factor activity
IUZ65_RS10600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IUZ65_RS10605	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IUZ65_RS10610	COG2885	chlorophyll binding
IUZ65_RS10615	COG0823	Involved in the tonB-independent uptake of proteins
IUZ65_RS10630	COG0811	peptide transport
IUZ65_RS10635	COG0824	Thioesterase
IUZ65_RS10640	COG3790	cyd operon protein YbgE
IUZ65_RS10645	COG0835	chemotaxis
IUZ65_RS10645	COG0784	Response regulator, receiver
IUZ65_RS10650	COG4890	Cyd operon protein YbgT
IUZ65_RS10655	COG1294	oxidase, subunit
IUZ65_RS10660	COG1271	oxidase subunit
IUZ65_RS10665	COG2255	four-way junction helicase activity
IUZ65_RS10670	COG0632	four-way junction helicase activity
IUZ65_RS10675	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IUZ65_RS10685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IUZ65_RS10690	COG4106	trans-aconitate 2-methyltransferase activity
IUZ65_RS10695	COG0500	methyltransferase
IUZ65_RS10700	COG0189	ligase activity
IUZ65_RS10700	COG4067	protein conserved in archaea
IUZ65_RS10715	COG1435	thymidine kinase activity
IUZ65_RS10725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IUZ65_RS10730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IUZ65_RS10735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IUZ65_RS10740	COG3012	SEC-C Motif Domain Protein
IUZ65_RS10745	COG0140	phosphoribosyl-ATP diphosphatase activity
IUZ65_RS10745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IUZ65_RS10755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IUZ65_RS10760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IUZ65_RS10765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IUZ65_RS10765	COG0131	Imidazoleglycerol-phosphate dehydratase
IUZ65_RS10770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IUZ65_RS10775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IUZ65_RS10780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IUZ65_RS10785	COG1757	Na H antiporter
IUZ65_RS10795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUZ65_RS10800	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IUZ65_RS10810	COG1199	ATP-dependent helicase activity
IUZ65_RS10815	COG0730	response to heat
IUZ65_RS10830	COG1309	transcriptional regulator
IUZ65_RS10895	COG5001	Diguanylate cyclase
IUZ65_RS10925	COG2207	Transcriptional regulator
IUZ65_RS10945	COG1741	Belongs to the pirin family
IUZ65_RS10950	COG2259	Doxx family
IUZ65_RS10955	COG0583	DNA-binding transcription factor activity
IUZ65_RS10975	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS11020	COG3300	MHYT domain
IUZ65_RS11020	COG5001	Diguanylate cyclase
IUZ65_RS11025	COG3706	GGDEF domain
IUZ65_RS11030	COG0501	Belongs to the peptidase M48B family
IUZ65_RS11055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IUZ65_RS11060	COG2194	sulfuric ester hydrolase activity
IUZ65_RS11090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IUZ65_RS11095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IUZ65_RS11100	COG3069	C4-dicarboxylate transmembrane transporter activity
IUZ65_RS11110	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IUZ65_RS11130	COG3901	Regulator of nitric oxide reductase transcription
IUZ65_RS11130	COG0348	domain, Protein
IUZ65_RS11165	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IUZ65_RS11170	COG1946	Acyl-CoA thioesterase
IUZ65_RS11175	COG3681	Belongs to the UPF0597 family
IUZ65_RS11180	COG1522	sequence-specific DNA binding
IUZ65_RS11190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUZ65_RS11215	COG3104	oligopeptide transport
IUZ65_RS11225	COG0444	Belongs to the ABC transporter superfamily
IUZ65_RS11230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IUZ65_RS11235	COG0601	transmembrane transport
IUZ65_RS11245	COG0314	molybdopterin synthase activity
IUZ65_RS11250	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IUZ65_RS11255	COG0315	cyclic pyranopterin monophosphate synthase activity
IUZ65_RS11260	COG0521	Mo-molybdopterin cofactor biosynthetic process
IUZ65_RS11265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IUZ65_RS11270	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IUZ65_RS11275	COG2198	Histidine kinase
IUZ65_RS11285	COG0556	nucleotide-excision repair
IUZ65_RS11300	COG2878	Part of a membrane complex involved in electron transport
IUZ65_RS11310	COG4658	electron transport chain
IUZ65_RS11315	COG4659	FMN binding
IUZ65_RS11320	COG4660	Part of a membrane complex involved in electron transport
IUZ65_RS11325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IUZ65_RS11330	COG0346	lactoylglutathione lyase activity
IUZ65_RS11335	COG3102	Protein conserved in bacteria
IUZ65_RS11340	COG0018	arginyl-trna synthetase
IUZ65_RS11360	COG1918	ferrous iron import across plasma membrane
IUZ65_RS11365	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IUZ65_RS11370	COG1121	(ABC) transporter
IUZ65_RS11375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IUZ65_RS11390	COG1454	alcohol dehydrogenase
IUZ65_RS11390	COG1012	belongs to the aldehyde dehydrogenase family
IUZ65_RS11395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IUZ65_RS11400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IUZ65_RS11405	COG3081	Nucleoid-associated protein
IUZ65_RS11430	COG0583	DNA-binding transcription factor activity
IUZ65_RS11440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IUZ65_RS11455	COG1737	Transcriptional regulator
IUZ65_RS11460	COG0800	Aldolase
IUZ65_RS11465	COG3734	2-keto-3-deoxy-galactonokinase
IUZ65_RS11470	COG0800	Aldolase
IUZ65_RS11475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUZ65_RS11480	COG4145	pantothenate transmembrane transporter activity
IUZ65_RS11490	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IUZ65_RS11495	COG1737	Transcriptional regulator
IUZ65_RS11525	COG4191	Histidine kinase
IUZ65_RS11550	COG2814	Major facilitator Superfamily
IUZ65_RS11560	COG4977	sequence-specific DNA binding
IUZ65_RS11565	COG1335	isochorismatase
IUZ65_RS11595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IUZ65_RS11605	COG0778	Nitroreductase
IUZ65_RS11610	COG1902	pentaerythritol trinitrate reductase activity
IUZ65_RS11610	COG0446	pyridine nucleotide-disulphide oxidoreductase
IUZ65_RS11615	COG0616	signal peptide processing
IUZ65_RS11620	COG0252	asparaginase activity
IUZ65_RS11625	COG3139	Protein of unknown function (DUF1315)
IUZ65_RS11635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IUZ65_RS11640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IUZ65_RS11645	COG0676	glucose-6-phosphate 1-epimerase activity
IUZ65_RS11650	COG2226	methyltransferase
IUZ65_RS11660	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IUZ65_RS11665	COG2983	Belongs to the UPF0260 family
IUZ65_RS11680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IUZ65_RS11685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IUZ65_RS11690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IUZ65_RS11695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IUZ65_RS11700	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS11705	COG0583	DNA-binding transcription factor activity
IUZ65_RS11710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IUZ65_RS11715	COG1286	toxin biosynthetic process
IUZ65_RS11720	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IUZ65_RS11725	COG0285	dihydrofolate synthase activity
IUZ65_RS11730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IUZ65_RS11735	COG0101	tRNA pseudouridine synthase activity
IUZ65_RS11745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IUZ65_RS11750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IUZ65_RS11755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IUZ65_RS11765	COG0297	glycogen (starch) synthase activity
IUZ65_RS11775	COG3101	peptidyl-lysine hydroxylation
IUZ65_RS11780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IUZ65_RS11785	COG2890	protein-(glutamine-N5) methyltransferase activity
IUZ65_RS11790	COG2840	Smr protein MutS2
IUZ65_RS11795	COG2062	phosphohistidine phosphatase, SixA
IUZ65_RS11800	COG1025	Belongs to the peptidase M16 family
IUZ65_RS11805	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUZ65_RS11805	COG1024	Enoyl-CoA hydratase
IUZ65_RS11810	COG0183	Belongs to the thiolase family
IUZ65_RS11825	COG2067	long-chain fatty acid transport protein
IUZ65_RS11830	COG2067	long-chain fatty acid transport protein
IUZ65_RS11835	COG2853	Lipoprotein
IUZ65_RS11850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IUZ65_RS11855	COG1138	Cytochrome C-type biogenesis protein
IUZ65_RS11870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IUZ65_RS11875	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IUZ65_RS11880	COG4133	protoheme IX ABC transporter activity
IUZ65_RS11890	COG0835	chemotaxis
IUZ65_RS11900	COG1192	Involved in chromosome partitioning
IUZ65_RS11905	COG2201	protein-glutamate methylesterase activity
IUZ65_RS11910	COG2198	Histidine kinase
IUZ65_RS11910	COG0643	Histidine kinase
IUZ65_RS11910	COG0784	Response regulator, receiver
IUZ65_RS11915	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IUZ65_RS11955	COG1987	bacterial-type flagellum assembly
IUZ65_RS12005	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IUZ65_RS12015	COG1677	Flagellar hook-basal body complex protein FliE
IUZ65_RS12035	COG1516	flagellar protein fliS
IUZ65_RS12045	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IUZ65_RS12050	COG1334	flagellar protein FlaG
IUZ65_RS12060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUZ65_RS12075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUZ65_RS12085	COG1705	Flagellar rod assembly protein muramidase FlgJ
IUZ65_RS12085	COG3951	Flagellar rod assembly protein muramidase FlgJ
IUZ65_RS12090	COG1706	bacterial-type flagellum-dependent cell motility
IUZ65_RS12095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IUZ65_RS12105	COG4787	bacterial-type flagellum-dependent cell motility
IUZ65_RS12110	COG1749	Flagellar hook protein flgE
IUZ65_RS12120	COG1558	bacterial-type flagellum-dependent cell motility
IUZ65_RS12125	COG1815	bacterial-type flagellum-dependent cell motility
IUZ65_RS12130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IUZ65_RS12135	COG0784	Response regulator, receiver
IUZ65_RS12135	COG0835	chemotaxis
IUZ65_RS12200	COG1349	DNA-binding transcription factor activity
IUZ65_RS12210	COG1028	Short-chain dehydrogenase reductase Sdr
IUZ65_RS12215	COG3731	PTS system glucitol sorbitol-specific IIA component
IUZ65_RS12225	COG3730	PTS system glucitol sorbitol-specific
IUZ65_RS12230	COG0517	IMP dehydrogenase activity
IUZ65_RS12230	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IUZ65_RS12240	COG1609	Transcriptional regulator
IUZ65_RS12260	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IUZ65_RS12265	COG3715	PTS system
IUZ65_RS12270	COG3716	PTS system mannose fructose sorbose family IID component
IUZ65_RS12275	COG2140	Oxalate decarboxylase
IUZ65_RS12280	COG2942	2-epimerase
IUZ65_RS12300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IUZ65_RS12305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IUZ65_RS12320	COG0488	(ABC) transporter
IUZ65_RS12325	COG0066	3-isopropylmalate dehydratase activity
IUZ65_RS12330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IUZ65_RS12335	COG0583	DNA-binding transcription factor activity
IUZ65_RS12340	COG0596	Alpha beta hydrolase
IUZ65_RS12345	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IUZ65_RS12360	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IUZ65_RS12365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IUZ65_RS12370	COG1053	succinate dehydrogenase
IUZ65_RS12375	COG0583	DNA-binding transcription factor activity
IUZ65_RS12380	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IUZ65_RS12385	COG1027	Aspartate ammonia-lyase
IUZ65_RS12415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IUZ65_RS12420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IUZ65_RS12470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IUZ65_RS12480	COG1028	Short-chain dehydrogenase reductase Sdr
IUZ65_RS12500	COG2217	Heavy metal translocating P-type atpase
IUZ65_RS12500	COG2608	mercury ion transmembrane transporter activity
IUZ65_RS12525	COG2840	Smr protein MutS2
IUZ65_RS12530	COG1187	pseudouridine synthase activity
IUZ65_RS12535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IUZ65_RS12545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IUZ65_RS12550	COG2912	Transglutaminase-like superfamily
IUZ65_RS12560	COG2890	protein-(glutamine-N5) methyltransferase activity
IUZ65_RS12565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IUZ65_RS12570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IUZ65_RS12575	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IUZ65_RS12580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IUZ65_RS12585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IUZ65_RS12590	COG0193	aminoacyl-tRNA hydrolase activity
IUZ65_RS12670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUZ65_RS12680	COG1702	phosphate starvation-inducible protein PhoH
IUZ65_RS12685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IUZ65_RS12690	COG4535	Mg2 and Co2 transporter CorC
IUZ65_RS12695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IUZ65_RS12700	COG2888	peptidyl-tyrosine sulfation
IUZ65_RS12705	COG0495	leucyl-tRNA aminoacylation
IUZ65_RS12710	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IUZ65_RS12715	COG1466	dna polymerase III delta subunit
IUZ65_RS12720	COG0799	negative regulation of ribosome biogenesis
IUZ65_RS12725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IUZ65_RS12730	COG0768	penicillin binding
IUZ65_RS12735	COG0772	Belongs to the SEDS family
IUZ65_RS12740	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IUZ65_RS12745	COG1686	Belongs to the peptidase S11 family
IUZ65_RS12755	COG0321	lipoyl(octanoyl) transferase activity
IUZ65_RS12760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IUZ65_RS12770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IUZ65_RS12780	COG1473	amidohydrolase
IUZ65_RS12785	COG0366	Alpha amylase catalytic
IUZ65_RS12790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IUZ65_RS12790	COG1263	PTS System
IUZ65_RS12795	COG1609	Transcriptional regulator
IUZ65_RS12805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IUZ65_RS12810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IUZ65_RS12815	COG2011	ABC-type metal ion transport system permease component
IUZ65_RS12820	COG1464	Belongs to the NlpA lipoprotein family
IUZ65_RS12840	COG4565	transcriptional regulatory protein
IUZ65_RS12845	COG3290	protein histidine kinase activity
IUZ65_RS12855	COG0351	phosphomethylpyrimidine kinase
IUZ65_RS12860	COG1116	anion transmembrane transporter activity
IUZ65_RS12865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IUZ65_RS12870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IUZ65_RS12875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IUZ65_RS12880	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IUZ65_RS12890	COG1720	tRNA m6t6A37 methyltransferase activity
IUZ65_RS12895	COG0442	prolyl-tRNA aminoacylation
IUZ65_RS12915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IUZ65_RS12920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IUZ65_RS12935	COG1477	protein flavinylation
IUZ65_RS12940	COG2871	sodium ion transport
IUZ65_RS12945	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IUZ65_RS12965	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IUZ65_RS12970	COG0271	Belongs to the BolA IbaG family
IUZ65_RS12975	COG2813	Specifically methylates the guanine in position
IUZ65_RS12985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IUZ65_RS13000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IUZ65_RS13005	COG0693	protein deglycase activity
IUZ65_RS13010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IUZ65_RS13015	COG2166	iron-sulfur cluster assembly
IUZ65_RS13020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IUZ65_RS13025	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IUZ65_RS13045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUZ65_RS13050	COG1074	ATP-dependent DNA helicase activity
IUZ65_RS13055	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IUZ65_RS13060	COG0583	DNA-binding transcription factor activity
IUZ65_RS13065	COG3706	GGDEF domain
IUZ65_RS13080	COG1566	PFAM secretion protein HlyD family protein
IUZ65_RS13085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUZ65_RS13090	COG0765	amino acid transport
IUZ65_RS13095	COG3141	response to X-ray
IUZ65_RS13100	COG2171	N-acyltransferase activity
IUZ65_RS13105	COG3835	regulator
IUZ65_RS13110	COG2610	gluconate transmembrane transporter activity
IUZ65_RS13115	COG1929	Belongs to the glycerate kinase type-1 family
IUZ65_RS13120	COG1609	Transcriptional regulator
IUZ65_RS13130	COG2017	converts alpha-aldose to the beta-anomer
IUZ65_RS13145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IUZ65_RS13165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IUZ65_RS13165	COG1263	PTS System
IUZ65_RS13170	COG3250	beta-galactosidase activity
IUZ65_RS13185	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS13190	COG1175	transmembrane transport
IUZ65_RS13250	COG4964	Belongs to the GSP D family
IUZ65_RS13270	COG1022	Amp-dependent synthetase and ligase
IUZ65_RS13280	COG4628	conserved protein (DUF2132)
IUZ65_RS13285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IUZ65_RS13290	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IUZ65_RS13300	COG0560	Phosphoserine phosphatase
IUZ65_RS13310	COG0813	purine-nucleoside phosphorylase activity
IUZ65_RS13320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IUZ65_RS13325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IUZ65_RS13330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IUZ65_RS13335	COG0084	hydrolase, TatD family'
IUZ65_RS13345	COG1744	ABC transporter substrate-binding protein PnrA-like
IUZ65_RS13350	COG3845	ABC transporter
IUZ65_RS13355	COG4603	Belongs to the binding-protein-dependent transport system permease family
IUZ65_RS13360	COG1079	Belongs to the binding-protein-dependent transport system permease family
IUZ65_RS13380	COG3153	acetyltransferase
IUZ65_RS13385	COG3154	lipid carrier protein
IUZ65_RS13395	COG0826	peptidase U32
IUZ65_RS13400	COG0826	peptidase U32
IUZ65_RS13405	COG0534	Mate efflux family protein
IUZ65_RS13420	COG1185	polyribonucleotide nucleotidyltransferase activity
IUZ65_RS13430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IUZ65_RS13435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IUZ65_RS13445	COG0195	Participates in both transcription termination and antitermination
IUZ65_RS13450	COG0779	Required for maturation of 30S ribosomal subunits
IUZ65_RS13465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IUZ65_RS13475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IUZ65_RS13480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IUZ65_RS13485	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IUZ65_RS13490	COG1534	Rna-binding protein
IUZ65_RS13495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IUZ65_RS13500	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IUZ65_RS13505	COG2027	D-alanyl-D-alanine carboxypeptidase
IUZ65_RS13510	COG2239	Acts as a magnesium transporter
IUZ65_RS13515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IUZ65_RS13520	COG0739	heme binding
IUZ65_RS13525	COG1605	Chorismate mutase
IUZ65_RS13525	COG0287	Prephenate dehydrogenase
IUZ65_RS13530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IUZ65_RS13535	COG3275	phosphorelay sensor kinase activity
IUZ65_RS13540	COG3279	Response regulator of the LytR AlgR family
IUZ65_RS13550	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IUZ65_RS13560	COG1966	Carbon starvation protein
IUZ65_RS13565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IUZ65_RS13570	COG1047	Peptidyl-prolyl cis-trans
IUZ65_RS13585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IUZ65_RS13590	COG0196	riboflavin kinase activity
IUZ65_RS13595	COG0728	peptidoglycan biosynthetic process
IUZ65_RS13600	COG0268	Binds directly to 16S ribosomal RNA
IUZ65_RS13605	COG0640	Transcriptional regulator
IUZ65_RS13610	COG0583	DNA-binding transcription factor activity
IUZ65_RS13615	COG1283	sodium-dependent phosphate transmembrane transporter activity
IUZ65_RS13620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IUZ65_RS13625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IUZ65_RS13635	COG0494	nUDIX hydrolase
IUZ65_RS13640	COG3066	DNA modification
IUZ65_RS13660	COG3290	protein histidine kinase activity
IUZ65_RS13660	COG3829	transcription factor binding
IUZ65_RS13670	COG1752	Esterase of the alpha-beta hydrolase superfamily
IUZ65_RS13675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IUZ65_RS13680	COG1643	Atp-dependent helicase
IUZ65_RS13695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IUZ65_RS13705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IUZ65_RS13710	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IUZ65_RS13715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IUZ65_RS13720	COG0842	Transport permease protein
IUZ65_RS13725	COG1131	(ABC) transporter
IUZ65_RS13730	COG0288	reversible hydration of carbon dioxide
IUZ65_RS13745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUZ65_RS13750	COG0508	dehydrogenase complex catalyzes the overall conversion of
IUZ65_RS13755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IUZ65_RS13770	COG0157	Belongs to the NadC ModD family
IUZ65_RS13785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IUZ65_RS13790	COG1459	type II secretion system
IUZ65_RS13805	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IUZ65_RS13810	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IUZ65_RS13820	COG0336	Belongs to the RNA methyltransferase TrmD family
IUZ65_RS13825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IUZ65_RS13835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IUZ65_RS13840	COG4137	Cytochrome C assembly protein
IUZ65_RS13845	COG4536	flavin adenine dinucleotide binding
IUZ65_RS13860	COG0612	Peptidase, M16
IUZ65_RS13865	COG1238	metal cluster binding
IUZ65_RS13875	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IUZ65_RS13880	COG0511	ligase activity, forming carbon-carbon bonds
IUZ65_RS13880	COG5016	pyruvate
IUZ65_RS13885	COG3630	sodium ion export across plasma membrane
IUZ65_RS13940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IUZ65_RS13945	COG0527	aspartate kinase activity
IUZ65_RS13960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IUZ65_RS13965	COG1119	ATPase activity
IUZ65_RS13970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IUZ65_RS13975	COG0505	Belongs to the CarA family
IUZ65_RS13980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IUZ65_RS13985	COG0494	nUDIX hydrolase
IUZ65_RS13995	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IUZ65_RS14000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IUZ65_RS14005	COG0849	cell division
IUZ65_RS14010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IUZ65_RS14025	COG0772	Belongs to the SEDS family
IUZ65_RS14030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IUZ65_RS14040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IUZ65_RS14050	COG0768	penicillin binding
IUZ65_RS14055	COG3116	cell division
IUZ65_RS14060	COG0275	rRNA processing
IUZ65_RS14090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IUZ65_RS14095	COG3107	peptidoglycan biosynthetic process
IUZ65_RS14115	COG2969	positive regulation of protein catabolic process
IUZ65_RS14120	COG0625	glutathione transferase activity
IUZ65_RS14125	COG2857	Cytochrome c1
IUZ65_RS14130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IUZ65_RS14135	COG0723	plastoquinol--plastocyanin reductase activity
IUZ65_RS14145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IUZ65_RS14150	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IUZ65_RS14160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUZ65_RS14165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUZ65_RS14180	COG0187	DNA topoisomerase II activity
IUZ65_RS14185	COG3150	esterase
IUZ65_RS14195	COG3151	Protein conserved in bacteria
IUZ65_RS14200	COG0494	nUDIX hydrolase
IUZ65_RS14205	COG1538	Outer membrane efflux protein
IUZ65_RS14210	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IUZ65_RS14220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IUZ65_RS14225	COG3025	triphosphatase activity
IUZ65_RS14230	COG1392	Phosphate transport regulator
IUZ65_RS14235	COG0306	phosphate transporter
IUZ65_RS14240	COG4991	sh3 domain protein
IUZ65_RS14250	COG3409	Peptidoglycan-binding domain 1 protein
IUZ65_RS14250	COG3267	Type II secretory pathway component ExeA
IUZ65_RS14255	COG0617	tRNA 3'-terminal CCA addition
IUZ65_RS14260	COG1968	undecaprenyl-diphosphatase activity
IUZ65_RS14265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IUZ65_RS14270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IUZ65_RS14275	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IUZ65_RS14280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IUZ65_RS14285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IUZ65_RS14290	COG1610	YqeY-like protein
IUZ65_RS14340	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IUZ65_RS14345	COG3457	Alanine racemase
IUZ65_RS14360	COG1735	metal-dependent hydrolase with the TIM-barrel fold
IUZ65_RS14370	COG2188	Transcriptional regulator
IUZ65_RS14390	COG2204	response regulator
IUZ65_RS14395	COG3852	Histidine kinase
IUZ65_RS14405	COG1858	cytochrome C peroxidase
IUZ65_RS14410	COG1858	cytochrome C peroxidase
IUZ65_RS14415	COG0723	plastoquinol--plastocyanin reductase activity
IUZ65_RS14440	COG2197	response regulator
IUZ65_RS14445	COG0583	DNA-binding transcription factor activity
IUZ65_RS14450	COG1328	CTP reductase activity
IUZ65_RS14455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IUZ65_RS14460	COG2186	Transcriptional regulator
IUZ65_RS14485	COG2731	YhcH YjgK YiaL family protein
IUZ65_RS14490	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IUZ65_RS14495	COG1063	alcohol dehydrogenase
IUZ65_RS14500	COG0246	Mannitol dehydrogenase
IUZ65_RS14510	COG0800	Aldolase
IUZ65_RS14515	COG0583	DNA-binding transcription factor activity
IUZ65_RS14525	COG1012	belongs to the aldehyde dehydrogenase family
IUZ65_RS14535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IUZ65_RS14555	COG3321	synthase
IUZ65_RS14555	COG1028	Short-chain dehydrogenase reductase Sdr
IUZ65_RS14555	COG0604	alcohol dehydrogenase
IUZ65_RS14575	COG3284	Transcriptional regulator
IUZ65_RS14580	COG1461	Dihydroxyacetone kinase
IUZ65_RS14585	COG2376	Dihydroxyacetone kinase
IUZ65_RS14590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IUZ65_RS14595	COG1349	DNA-binding transcription factor activity
IUZ65_RS14600	COG0469	pyruvate kinase activity
IUZ65_RS14610	COG0028	Belongs to the TPP enzyme family
IUZ65_RS14615	COG1022	Amp-dependent synthetase and ligase
IUZ65_RS14650	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IUZ65_RS14665	COG0795	lipopolysaccharide-transporting ATPase activity
IUZ65_RS14670	COG0795	lipopolysaccharide-transporting ATPase activity
IUZ65_RS14680	COG2927	DNA polymerase III (CHI subunit)
IUZ65_RS14685	COG0525	valine-tRNA ligase activity
IUZ65_RS14695	COG0456	acetyltransferase
IUZ65_RS14705	COG0840	transmembrane signaling receptor activity
IUZ65_RS14720	COG1288	antiporter activity
IUZ65_RS14735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IUZ65_RS14740	COG0540	Belongs to the ATCase OTCase family
IUZ65_RS14745	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IUZ65_RS14750	COG1438	arginine binding
IUZ65_RS14755	COG0251	oxidation-reduction process
IUZ65_RS14760	COG0204	Acyl-transferase
IUZ65_RS14765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IUZ65_RS14770	COG5007	Belongs to the BolA IbaG family
IUZ65_RS14775	COG3113	response to antibiotic
IUZ65_RS14780	COG2854	intermembrane phospholipid transfer
IUZ65_RS14785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IUZ65_RS14790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IUZ65_RS14795	COG1127	ABC transporter
IUZ65_RS14805	COG0517	IMP dehydrogenase activity
IUZ65_RS14805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IUZ65_RS14810	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IUZ65_RS14820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IUZ65_RS14825	COG1137	ATPase activity
IUZ65_RS14840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS14845	COG1660	Displays ATPase and GTPase activities
IUZ65_RS14850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS14855	COG2239	Acts as a magnesium transporter
IUZ65_RS14860	COG0312	modulator of DNA gyrase
IUZ65_RS14870	COG0312	modulator of DNA gyrase
IUZ65_RS14875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IUZ65_RS14880	COG3164	Protein of unknown function
IUZ65_RS14885	COG1530	ribonuclease E activity
IUZ65_RS14890	COG0424	maF-like protein
IUZ65_RS14895	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IUZ65_RS14900	COG1792	Involved in formation and maintenance of cell shape
IUZ65_RS14905	COG1077	Cell shape determining protein MreB Mrl
IUZ65_RS14940	COG2165	general secretion pathway protein
IUZ65_RS14950	COG1459	type II secretion system
IUZ65_RS14955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IUZ65_RS14965	COG3267	Type II secretory pathway component ExeA
IUZ65_RS14965	COG3409	Peptidoglycan-binding domain 1 protein
IUZ65_RS14970	COG1450	Type ii and iii secretion system protein
IUZ65_RS14990	COG2200	EAL domain
IUZ65_RS14990	COG2199	diguanylate cyclase activity
IUZ65_RS14995	COG0629	single-stranded DNA binding
IUZ65_RS15010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IUZ65_RS15020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IUZ65_RS15025	COG0527	aspartate kinase activity
IUZ65_RS15040	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IUZ65_RS15105	COG0175	sulfate reduction
IUZ65_RS15110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IUZ65_RS15115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IUZ65_RS15135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IUZ65_RS15140	COG0735	belongs to the Fur family
IUZ65_RS15150	COG0166	Belongs to the GPI family
IUZ65_RS15165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IUZ65_RS15185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IUZ65_RS15195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IUZ65_RS15200	COG0557	exoribonuclease II activity
IUZ65_RS15205	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IUZ65_RS15210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IUZ65_RS15220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IUZ65_RS15225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IUZ65_RS15230	COG0049	tRNA binding
IUZ65_RS15245	COG2923	Belongs to the DsrF TusC family
IUZ65_RS15255	COG2964	Protein conserved in bacteria
IUZ65_RS15260	COG0545	Peptidyl-prolyl cis-trans isomerase
IUZ65_RS15280	COG1047	Peptidyl-prolyl cis-trans
IUZ65_RS15295	COG2249	NAD(P)H dehydrogenase (quinone) activity
IUZ65_RS15300	COG0488	(ABC) transporter
IUZ65_RS15310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IUZ65_RS15310	COG0519	Catalyzes the synthesis of GMP from XMP
IUZ65_RS15320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IUZ65_RS15325	COG0429	hydrolase of the alpha beta-hydrolase fold
IUZ65_RS15330	COG3089	Belongs to the UPF0270 family
IUZ65_RS15335	COG3954	Phosphoribulokinase
IUZ65_RS15340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IUZ65_RS15345	COG0454	-acetyltransferase
IUZ65_RS15370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IUZ65_RS15370	COG0165	Argininosuccinate lyase
IUZ65_RS15375	COG0137	argininosuccinate synthase activity
IUZ65_RS15380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IUZ65_RS15385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IUZ65_RS15390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IUZ65_RS15405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IUZ65_RS15410	COG0460	homoserine dehydrogenase
IUZ65_RS15410	COG0527	aspartate kinase activity
IUZ65_RS15415	COG0626	cystathionine gamma-synthase activity
IUZ65_RS15420	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
IUZ65_RS15425	COG0281	malic enzyme
IUZ65_RS15430	COG0254	rRNA binding
IUZ65_RS15435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IUZ65_RS15440	COG1609	Transcriptional regulator
IUZ65_RS15450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IUZ65_RS15455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IUZ65_RS15460	COG1575	Belongs to the MenA family. Type 1 subfamily
IUZ65_RS15465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IUZ65_RS15470	COG2909	trisaccharide binding
IUZ65_RS15500	COG3074	FtsZ-dependent cytokinesis
IUZ65_RS15505	COG1494	fructose-1,6-bisphosphatase
IUZ65_RS15520	COG3152	Membrane
IUZ65_RS15535	COG0205	6-phosphofructokinase activity
IUZ65_RS15550	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS15555	COG2205	protein histidine kinase activity
IUZ65_RS15560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IUZ65_RS15565	COG3030	protein affecting phage T7 exclusion by the F plasmid
IUZ65_RS15570	COG1027	Aspartate ammonia-lyase
IUZ65_RS15575	COG4232	protein-disulfide reductase activity
IUZ65_RS15590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUZ65_RS15595	COG1051	belongs to the nudix hydrolase family
IUZ65_RS15600	COG0784	Response regulator, receiver
IUZ65_RS15600	COG2205	protein histidine kinase activity
IUZ65_RS15605	COG2814	Major facilitator Superfamily
IUZ65_RS15620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IUZ65_RS15625	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IUZ65_RS15630	COG0511	ligase activity, forming carbon-carbon bonds
IUZ65_RS15635	COG0439	Biotin carboxylase
IUZ65_RS15640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IUZ65_RS15655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IUZ65_RS15660	COG2264	protein methyltransferase activity
IUZ65_RS15670	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IUZ65_RS15675	COG1522	sequence-specific DNA binding
IUZ65_RS15680	COG0626	cystathionine gamma-synthase activity
IUZ65_RS15700	COG1473	amidohydrolase
IUZ65_RS15705	COG0251	oxidation-reduction process
IUZ65_RS15725	COG1757	Na H antiporter
IUZ65_RS15730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IUZ65_RS15735	COG1940	carbohydrate kinase activity
IUZ65_RS15740	COG0789	Transcriptional regulator
IUZ65_RS15745	COG0138	bifunctional purine biosynthesis protein purh
IUZ65_RS15750	COG0151	Belongs to the GarS family
IUZ65_RS15765	COG1253	flavin adenine dinucleotide binding
IUZ65_RS15775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IUZ65_RS15780	COG1573	uracil-dna glycosylase
IUZ65_RS15790	COG2816	NAD+ diphosphatase activity
IUZ65_RS15795	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IUZ65_RS15810	COG0222	ribosome binding
IUZ65_RS15815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IUZ65_RS15820	COG0081	regulation of translation
IUZ65_RS15830	COG0250	Participates in transcription elongation, termination and antitermination
IUZ65_RS15835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IUZ65_RS15840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IUZ65_RS15860	COG1072	(Pantothenic acid kinase))
IUZ65_RS15865	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IUZ65_RS15865	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IUZ65_RS15870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IUZ65_RS15880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUZ65_RS15955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IUZ65_RS15960	COG4206	TonB-dependent receptor
IUZ65_RS15965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IUZ65_RS15980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUZ65_RS15985	COG0534	Mate efflux family protein
IUZ65_RS15990	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IUZ65_RS16000	COG1522	sequence-specific DNA binding
IUZ65_RS16005	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IUZ65_RS16010	COG2937	Belongs to the GPAT DAPAT family
IUZ65_RS16015	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IUZ65_RS16020	COG3161	chorismate lyase activity
IUZ65_RS16030	COG0705	Rhomboid family
IUZ65_RS16035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUZ65_RS16045	COG2177	Part of the ABC transporter FtsEX involved in
IUZ65_RS16050	COG2884	Cell division ATP-binding protein ftsE
IUZ65_RS16055	COG0552	protein localization to endoplasmic reticulum
IUZ65_RS16060	COG0742	ribosomal rna small subunit methyltransferase
IUZ65_RS16070	COG2095	MarC family integral membrane protein
IUZ65_RS16105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IUZ65_RS16110	COG0640	Transcriptional regulator
IUZ65_RS16115	COG2267	carboxylic ester hydrolase activity
IUZ65_RS16120	COG0561	phosphatase activity
IUZ65_RS16135	COG3071	HemY protein
IUZ65_RS16140	COG2959	enzyme of heme biosynthesis
IUZ65_RS16145	COG1587	Uroporphyrinogen-III synthase
IUZ65_RS16155	COG3072	Adenylate cyclase
IUZ65_RS16160	COG1965	Belongs to the frataxin family
IUZ65_RS16170	COG0019	diaminopimelate decarboxylase activity
IUZ65_RS16175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IUZ65_RS16185	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUZ65_RS16190	COG1011	Hydrolase
IUZ65_RS16195	COG3706	GGDEF domain
IUZ65_RS16245	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IUZ65_RS16255	COG3118	belongs to the thioredoxin family
IUZ65_RS16260	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS16265	COG0248	Ppx GppA phosphatase
IUZ65_RS16270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IUZ65_RS16280	COG0514	ATP-dependent DNA helicase (RecQ)
IUZ65_RS16285	COG2962	Rard protein
IUZ65_RS16290	COG0210	DNA helicase
IUZ65_RS16300	COG3220	belongs to the UPF0276 family
IUZ65_RS16330	COG0006	proline dipeptidase activity
IUZ65_RS16330	COG0006	proline dipeptidase activity
IUZ65_RS16375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IUZ65_RS16385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IUZ65_RS16390	COG0408	coproporphyrinogen oxidase activity
IUZ65_RS16400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IUZ65_RS16410	COG0551	DNA topoisomerase type I activity
IUZ65_RS16415	COG2922	Belongs to the Smg family
IUZ65_RS16420	COG0758	DNA mediated transformation
IUZ65_RS16425	COG0242	peptide deformylase activity
IUZ65_RS16435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IUZ65_RS16435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IUZ65_RS16440	COG0569	domain protein
IUZ65_RS16445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IUZ65_RS16450	COG1272	protein, Hemolysin III
IUZ65_RS16455	COG4326	sporulation control protein
IUZ65_RS16465	COG3084	Protein conserved in bacteria
IUZ65_RS16475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IUZ65_RS16480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUZ65_RS16485	COG0606	chelatase, subunit chli
IUZ65_RS16495	COG3978	acetolactate synthase activity
IUZ65_RS16525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IUZ65_RS16535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IUZ65_RS16545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IUZ65_RS16550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IUZ65_RS16560	COG0356	it plays a direct role in the translocation of protons across the membrane
IUZ65_RS16565	COG3312	ion transport
IUZ65_RS16570	COG1475	DNA binding
IUZ65_RS16575	COG1192	Involved in chromosome partitioning
IUZ65_RS16580	COG0357	Ribosomal RNA small subunit methyltransferase G
IUZ65_RS16585	COG0445	tRNA wobble uridine modification
IUZ65_RS16590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IUZ65_RS16600	COG0706	membrane insertase activity
IUZ65_RS16615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IUZ65_RS16620	COG1126	abc transporter atp-binding protein
IUZ65_RS16640	COG1760	l-serine dehydratase
IUZ65_RS16650	COG0318	PFAM AMP-dependent synthetase and ligase
IUZ65_RS16655	COG2207	Transcriptional regulator
IUZ65_RS16660	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUZ65_RS16670	COG0641	radical SAM
IUZ65_RS16720	COG0516	GMP reductase activity
IUZ65_RS16725	COG5413	integral membrane protein
IUZ65_RS16730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IUZ65_RS16730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IUZ65_RS16740	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS16780	COG0545	Peptidyl-prolyl cis-trans isomerase
IUZ65_RS16785	COG0348	domain, Protein
IUZ65_RS16785	COG3901	Regulator of nitric oxide reductase transcription
IUZ65_RS16790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IUZ65_RS16815	COG0583	DNA-binding transcription factor activity
IUZ65_RS16820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUZ65_RS16835	COG0659	secondary active sulfate transmembrane transporter activity
IUZ65_RS16845	COG1879	ABC-type sugar transport system periplasmic component
IUZ65_RS16850	COG1803	Methylglyoxal synthase
IUZ65_RS16860	COG0210	DNA helicase
IUZ65_RS16865	COG1289	transmembrane transporter activity
IUZ65_RS16890	COG1879	ABC-type sugar transport system periplasmic component
IUZ65_RS16900	COG2827	Endonuclease containing a URI domain
IUZ65_RS16905	COG3132	Protein of unknown function, DUF480
IUZ65_RS16915	COG2926	Belongs to the UPF0265 family
IUZ65_RS16950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IUZ65_RS16955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IUZ65_RS16965	COG0633	Ferredoxin
IUZ65_RS16965	COG3217	Mosc domain protein beta barrel domain protein
IUZ65_RS16970	COG0418	dihydroorotase activity
IUZ65_RS16980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IUZ65_RS17035	COG2850	peptidyl-arginine hydroxylation
IUZ65_RS17045	COG1278	Cold shock
IUZ65_RS17055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUZ65_RS17060	COG0653	protein targeting
IUZ65_RS17085	COG1538	Outer membrane efflux protein
IUZ65_RS17100	COG1472	Belongs to the glycosyl hydrolase 3 family
IUZ65_RS17110	COG0488	(ABC) transporter
IUZ65_RS17115	COG4628	conserved protein (DUF2132)
IUZ65_RS17125	COG0454	-acetyltransferase
IUZ65_RS17150	COG0281	malic enzyme
IUZ65_RS17155	COG1280	lysine exporter protein (LysE YggA)
IUZ65_RS17160	COG2200	EAL domain
IUZ65_RS17180	COG0673	inositol 2-dehydrogenase activity
IUZ65_RS17210	COG2113	Glycine betaine
IUZ65_RS17220	COG2130	NADP-dependent
IUZ65_RS17225	COG1309	transcriptional regulator
IUZ65_RS17230	COG0583	DNA-binding transcription factor activity
IUZ65_RS17235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IUZ65_RS17245	COG0604	alcohol dehydrogenase
IUZ65_RS17250	COG0583	DNA-binding transcription factor activity
IUZ65_RS17255	COG2207	Transcriptional regulator
IUZ65_RS17260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IUZ65_RS17260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IUZ65_RS17260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS17265	COG1482	cell wall glycoprotein biosynthetic process
IUZ65_RS17275	COG0589	response to stress
IUZ65_RS17280	COG0840	transmembrane signaling receptor activity
IUZ65_RS17285	COG1901	pseudouridine methyltransferase
IUZ65_RS17290	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IUZ65_RS17300	COG0709	Synthesizes selenophosphate from selenide and ATP
IUZ65_RS17305	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IUZ65_RS17325	COG1132	(ABC) transporter
IUZ65_RS17345	COG0702	epimerase
IUZ65_RS17350	COG1309	transcriptional regulator
IUZ65_RS17365	COG1902	pentaerythritol trinitrate reductase activity
IUZ65_RS17380	COG2378	regulation of single-species biofilm formation
IUZ65_RS17410	COG0488	(ABC) transporter
IUZ65_RS17415	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS17445	COG0848	biopolymer transport protein
IUZ65_RS17450	COG0811	peptide transport
IUZ65_RS17455	COG0811	peptide transport
IUZ65_RS17465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IUZ65_RS17470	COG4607	ABC-type enterochelin transport system periplasmic component
IUZ65_RS17475	COG1120	ATPase activity
IUZ65_RS17490	COG2207	Transcriptional regulator
IUZ65_RS17490	COG3708	Transcriptional regulator
IUZ65_RS17535	COG1846	Transcriptional regulator
IUZ65_RS17540	COG2814	Major facilitator Superfamily
IUZ65_RS17565	COG4335	DNA alkylation repair
IUZ65_RS17585	COG0583	DNA-binding transcription factor activity
IUZ65_RS17590	COG1473	amidohydrolase
IUZ65_RS17595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IUZ65_RS17600	COG0006	proline dipeptidase activity
IUZ65_RS17605	COG2964	Protein conserved in bacteria
IUZ65_RS17610	COG0251	oxidation-reduction process
IUZ65_RS17615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IUZ65_RS17620	COG0840	transmembrane signaling receptor activity
IUZ65_RS17635	COG1063	alcohol dehydrogenase
IUZ65_RS17645	COG2814	Major facilitator Superfamily
IUZ65_RS17665	COG0625	glutathione transferase activity
IUZ65_RS17670	COG0348	domain, Protein
IUZ65_RS17685	COG2149	membrane
IUZ65_RS17695	COG3706	GGDEF domain
IUZ65_RS17715	COG0628	permease
IUZ65_RS17725	COG1566	PFAM secretion protein HlyD family protein
IUZ65_RS17735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IUZ65_RS17780	COG0662	Cupin 2, conserved barrel domain protein
IUZ65_RS17780	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IUZ65_RS17790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUZ65_RS17795	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IUZ65_RS17800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUZ65_RS17825	COG0438	transferase activity, transferring glycosyl groups
IUZ65_RS17830	COG1083	cytidylyl-transferase
IUZ65_RS17835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IUZ65_RS17850	COG2089	acid synthase
IUZ65_RS17895	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUZ65_RS17910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IUZ65_RS17920	COG0406	alpha-ribazole phosphatase activity
IUZ65_RS17925	COG1797	cobyrinic acid a,c-diamide synthase activity
IUZ65_RS17930	COG1492	cobalamin metabolic process
IUZ65_RS17950	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IUZ65_RS17955	COG1648	precorrin-2 dehydrogenase activity
IUZ65_RS17955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IUZ65_RS17995	COG4822	anaerobic cobalamin biosynthetic process
IUZ65_RS18000	COG1131	(ABC) transporter
IUZ65_RS18010	COG4139	cobalamin transport
IUZ65_RS18015	COG1120	ATPase activity
IUZ65_RS18035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IUZ65_RS18035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IUZ65_RS18035	COG1013	pyruvate-flavodoxin oxidoreductase activity
IUZ65_RS18035	COG0674	pyruvate-flavodoxin oxidoreductase activity
IUZ65_RS18040	COG0716	FMN binding
IUZ65_RS18045	COG2375	cellular response to nickel ion
IUZ65_RS18055	COG0656	L-ascorbic acid biosynthetic process
IUZ65_RS18065	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IUZ65_RS18075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IUZ65_RS18080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IUZ65_RS18085	COG0251	oxidation-reduction process
IUZ65_RS18090	COG0814	amino acid
IUZ65_RS18095	COG3033	Beta-eliminating lyase
IUZ65_RS18100	COG4702	Belongs to the UPF0303 family
IUZ65_RS18105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IUZ65_RS18105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS18105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS18110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IUZ65_RS18115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IUZ65_RS18120	COG1882	Formate acetyltransferase
IUZ65_RS18125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IUZ65_RS18135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IUZ65_RS18140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IUZ65_RS18145	COG2207	Transcriptional regulator
IUZ65_RS18165	COG0840	transmembrane signaling receptor activity
IUZ65_RS18185	COG1879	ABC-type sugar transport system periplasmic component
IUZ65_RS18190	COG1172	Belongs to the binding-protein-dependent transport system permease family
IUZ65_RS18195	COG1129	ABC transporter
IUZ65_RS18205	COG2390	Transcriptional regulator
IUZ65_RS18210	COG5001	Diguanylate cyclase
IUZ65_RS18210	COG3300	MHYT domain
IUZ65_RS18235	COG0189	ligase activity
IUZ65_RS18245	COG0189	ligase activity
IUZ65_RS18245	COG4067	protein conserved in archaea
IUZ65_RS18250	COG2239	Acts as a magnesium transporter
IUZ65_RS18295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IUZ65_RS18305	COG3069	C4-dicarboxylate transmembrane transporter activity
IUZ65_RS18310	COG2195	Cleaves the N-terminal amino acid of tripeptides
IUZ65_RS18330	COG1959	2 iron, 2 sulfur cluster binding
IUZ65_RS18350	COG2301	Belongs to the HpcH HpaI aldolase family
IUZ65_RS18365	COG4565	transcriptional regulatory protein
IUZ65_RS18380	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
IUZ65_RS18415	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IUZ65_RS18420	COG0511	ligase activity, forming carbon-carbon bonds
IUZ65_RS18420	COG5016	pyruvate
IUZ65_RS18430	COG1917	Cupin 2, conserved barrel domain protein
IUZ65_RS18430	COG4977	sequence-specific DNA binding
IUZ65_RS18450	COG2201	protein-glutamate methylesterase activity
IUZ65_RS18455	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IUZ65_RS18470	COG0840	transmembrane signaling receptor activity
IUZ65_RS18475	COG0643	Histidine kinase
IUZ65_RS18475	COG2198	Histidine kinase
IUZ65_RS18500	COG2197	response regulator
IUZ65_RS18530	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IUZ65_RS18560	COG2390	Transcriptional regulator
IUZ65_RS18565	COG1070	Carbohydrate kinase
IUZ65_RS18585	COG2207	Transcriptional regulator
IUZ65_RS18610	COG0596	Alpha beta hydrolase
IUZ65_RS18615	COG0840	transmembrane signaling receptor activity
IUZ65_RS18630	COG0840	transmembrane signaling receptor activity
IUZ65_RS18640	COG0641	radical SAM
IUZ65_RS18685	COG0714	Associated with various cellular activities
IUZ65_RS18695	COG3119	arylsulfatase activity
IUZ65_RS18700	COG3119	arylsulfatase activity
IUZ65_RS18705	COG1132	(ABC) transporter
IUZ65_RS18710	COG1132	(ABC) transporter
IUZ65_RS18735	COG1301	dicarboxylic acid transport
IUZ65_RS18740	COG2204	response regulator
IUZ65_RS18745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUZ65_RS18745	COG4191	Histidine kinase
IUZ65_RS18750	COG1278	Cold shock
IUZ65_RS18755	COG3304	Inner membrane component domain
IUZ65_RS18770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IUZ65_RS18775	COG0784	Response regulator, receiver
IUZ65_RS18775	COG0835	chemotaxis
IUZ65_RS18785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUZ65_RS18790	COG4989	oxidoreductase activity
IUZ65_RS18815	COG3710	Transcriptional regulator
IUZ65_RS18820	COG0366	Alpha amylase catalytic
IUZ65_RS18825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUZ65_RS18830	COG3530	Putative quorum-sensing-regulated virulence factor
IUZ65_RS18840	COG1396	sequence-specific DNA binding
IUZ65_RS18845	COG3135	benzoate transporter
IUZ65_RS18850	COG1115	amino acid carrier protein
IUZ65_RS18860	COG4948	Mandelate Racemase Muconate Lactonizing
IUZ65_RS18870	COG1115	amino acid carrier protein
IUZ65_RS18900	COG0583	DNA-binding transcription factor activity
IUZ65_RS18905	COG3300	MHYT domain
IUZ65_RS18905	COG5001	Diguanylate cyclase
IUZ65_RS18910	COG0443	Heat shock 70 kDa protein
IUZ65_RS18925	COG1126	abc transporter atp-binding protein
IUZ65_RS18940	COG0765	amino acid transport
IUZ65_RS18945	COG1609	Transcriptional regulator
IUZ65_RS18950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUZ65_RS18955	COG1879	ABC-type sugar transport system periplasmic component
IUZ65_RS18960	COG1172	Belongs to the binding-protein-dependent transport system permease family
IUZ65_RS18965	COG1129	ABC transporter
IUZ65_RS18970	COG1869	D-ribose catabolic process
IUZ65_RS18985	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS18990	COG0110	maltose O-acetyltransferase activity
IUZ65_RS19010	COG0765	amino acid transport
IUZ65_RS19020	COG1609	Transcriptional regulator
IUZ65_RS19025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS19025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS19030	COG1105	Belongs to the carbohydrate kinase PfkB family
IUZ65_RS19035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IUZ65_RS19035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IUZ65_RS19035	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IUZ65_RS19040	COG0531	amino acid
IUZ65_RS19050	COG0405	Gamma-glutamyltransferase
IUZ65_RS19070	COG1785	Belongs to the alkaline phosphatase family
IUZ65_RS19080	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IUZ65_RS19085	COG0583	DNA-binding transcription factor activity
IUZ65_RS19095	COG0156	8-amino-7-oxononanoate synthase activity
IUZ65_RS19105	COG0346	lactoylglutathione lyase activity
IUZ65_RS19115	COG0534	Mate efflux family protein
IUZ65_RS19120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IUZ65_RS19135	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS19150	COG3097	Belongs to the UPF0267 family
IUZ65_RS19170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IUZ65_RS19185	COG0673	inositol 2-dehydrogenase activity
IUZ65_RS19205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IUZ65_RS19230	COG1247	-acetyltransferase
IUZ65_RS19240	COG0697	spore germination
IUZ65_RS19270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IUZ65_RS19270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS19275	COG1461	Dihydroxyacetone kinase
IUZ65_RS19280	COG2376	Dihydroxyacetone kinase
IUZ65_RS19285	COG0371	Dehydrogenase
IUZ65_RS19315	COG1765	OsmC-like protein
IUZ65_RS19330	COG0583	DNA-binding transcription factor activity
IUZ65_RS19335	COG4175	Glycine betaine
IUZ65_RS19335	COG3448	diguanylate cyclase activity
IUZ65_RS19355	COG3842	ATPase activity
IUZ65_RS19360	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS19365	COG1175	transmembrane transport
IUZ65_RS19370	COG1653	transport
IUZ65_RS19375	COG1609	Transcriptional regulator
IUZ65_RS19380	COG0366	Alpha amylase catalytic
IUZ65_RS19390	COG1067	ATP-dependent peptidase activity
IUZ65_RS19405	COG3005	denitrification pathway
IUZ65_RS19410	COG3043	anaerobic respiration
IUZ65_RS19415	COG0348	domain, Protein
IUZ65_RS19420	COG0437	4 iron, 4 sulfur cluster binding
IUZ65_RS19435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IUZ65_RS19440	COG3850	Histidine kinase
IUZ65_RS19445	COG2197	response regulator
IUZ65_RS19460	COG5001	Diguanylate cyclase
IUZ65_RS19465	COG0583	DNA-binding transcription factor activity
IUZ65_RS19490	COG2084	Dehydrogenase
IUZ65_RS19495	COG3622	Belongs to the hyi family
IUZ65_RS19500	COG3960	tartronate-semialdehyde synthase activity
IUZ65_RS19515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUZ65_RS19520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUZ65_RS19535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IUZ65_RS19535	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS19540	COG1461	Dihydroxyacetone kinase
IUZ65_RS19545	COG2376	Dihydroxyacetone kinase
IUZ65_RS19565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUZ65_RS19580	COG3842	ATPase activity
IUZ65_RS19585	COG1070	Carbohydrate kinase
IUZ65_RS19590	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS19595	COG1175	transmembrane transport
IUZ65_RS19605	COG3958	Transketolase
IUZ65_RS19610	COG3959	Transketolase, thiamine diphosphate binding domain
IUZ65_RS19615	COG1737	Transcriptional regulator
IUZ65_RS19630	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS19640	COG3842	ATPase activity
IUZ65_RS19645	COG3842	ATPase activity
IUZ65_RS19650	COG3284	Transcriptional regulator
IUZ65_RS19655	COG0419	ATPase involved in DNA repair
IUZ65_RS19660	COG0420	3'-5' exonuclease activity
IUZ65_RS19665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IUZ65_RS19665	COG1263	PTS System
IUZ65_RS19670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IUZ65_RS19690	COG3833	ABC-type maltose transport systems, permease component
IUZ65_RS19695	COG1175	transmembrane transport
IUZ65_RS19705	COG3842	ATPase activity
IUZ65_RS19735	COG3437	response regulator, receiver
IUZ65_RS19735	COG3850	Histidine kinase
IUZ65_RS19735	COG2205	protein histidine kinase activity
IUZ65_RS19735	COG4999	Histidine kinase
IUZ65_RS19740	COG2204	response regulator
IUZ65_RS19755	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS19765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IUZ65_RS19790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IUZ65_RS19795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IUZ65_RS19800	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IUZ65_RS19835	COG0297	glycogen (starch) synthase activity
IUZ65_RS19845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IUZ65_RS19895	COG2197	response regulator
IUZ65_RS19905	COG2814	Major facilitator Superfamily
IUZ65_RS19910	COG0596	Alpha beta hydrolase
IUZ65_RS19925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IUZ65_RS19930	COG1640	4-alpha-glucanotransferase
IUZ65_RS19935	COG0058	SHG alpha-glucan phosphorylase activity
IUZ65_RS19970	COG1162	GTPase activity
IUZ65_RS19975	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IUZ65_RS20010	COG1132	(ABC) transporter
IUZ65_RS20020	COG0625	glutathione transferase activity
IUZ65_RS20025	COG0583	DNA-binding transcription factor activity
IUZ65_RS20030	COG0583	DNA-binding transcription factor activity
IUZ65_RS20035	COG0384	phenazine biosynthesis protein PhzF
IUZ65_RS20055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUZ65_RS20080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IUZ65_RS20085	COG0259	pyridoxamine-phosphate oxidase activity
IUZ65_RS20115	COG1444	tRNA N-acetyltransferase activity
IUZ65_RS20150	COG2084	Dehydrogenase
IUZ65_RS20175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IUZ65_RS20180	COG3706	GGDEF domain
IUZ65_RS20185	COG1566	PFAM secretion protein HlyD family protein
IUZ65_RS20200	COG3706	GGDEF domain
IUZ65_RS20215	COG0813	purine-nucleoside phosphorylase activity
IUZ65_RS20220	COG1846	Transcriptional regulator
IUZ65_RS20225	COG1917	Cupin 2, conserved barrel domain protein
IUZ65_RS20225	COG2169	Transcriptional regulator
IUZ65_RS20230	COG1960	acyl-CoA dehydrogenase activity
IUZ65_RS20265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUZ65_RS20280	COG1846	Transcriptional regulator
IUZ65_RS20295	COG3971	2-oxopent-4-enoate hydratase activity
IUZ65_RS20325	COG3384	dioxygenase
IUZ65_RS20335	COG2814	Major facilitator Superfamily
IUZ65_RS20360	COG0745	RESPONSE REGULATOR receiver
IUZ65_RS20365	COG0642	Histidine kinase
IUZ65_RS20410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IUZ65_RS20415	COG1349	DNA-binding transcription factor activity
IUZ65_RS20420	COG1129	ABC transporter
IUZ65_RS20425	COG1172	Belongs to the binding-protein-dependent transport system permease family
IUZ65_RS20435	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
IUZ65_RS20440	COG1070	Carbohydrate kinase
IUZ65_RS20450	COG0235	Class ii aldolase
IUZ65_RS20455	COG1454	alcohol dehydrogenase
IUZ65_RS20470	COG4667	esterase of the alpha-beta hydrolase superfamily
IUZ65_RS20475	COG0753	catalase activity
IUZ65_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
IUZ65_RS20495	COG1278	Cold shock
IUZ65_RS20510	COG1595	DNA-templated transcription, initiation
IUZ65_RS20515	COG3806	Anti-sigma factor
IUZ65_RS20525	COG0415	Belongs to the DNA photolyase family
IUZ65_RS20550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IUZ65_RS20595	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IUZ65_RS20615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IUZ65_RS20670	COG0546	phosphoglycolate phosphatase activity
IUZ65_RS20705	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUZ65_RS20725	COG0583	DNA-binding transcription factor activity
IUZ65_RS20730	COG2814	Major facilitator Superfamily
IUZ65_RS20735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUZ65_RS20760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IUZ65_RS20785	COG2304	oxidoreductase activity
IUZ65_RS20800	COG0443	Heat shock 70 kDa protein
IUZ65_RS20815	COG3040	lipid binding
IUZ65_RS20825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IUZ65_RS20840	COG1388	LysM domain
IUZ65_RS20840	COG1376	ErfK ybiS ycfS ynhG family protein
IUZ65_RS20860	COG3341	Caulimovirus viroplasmin
IUZ65_RS20860	COG0328	RNA-DNA hybrid ribonuclease activity
IUZ65_RS20875	COG1612	heme a metabolic process
IUZ65_RS20905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IUZ65_RS20915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IUZ65_RS20915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS20915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IUZ65_RS20925	COG3734	2-keto-3-deoxy-galactonokinase
IUZ65_RS20930	COG0800	Aldolase
IUZ65_RS20935	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IUZ65_RS20940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IUZ65_RS20940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IUZ65_RS20945	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IUZ65_RS20945	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IUZ65_RS20950	COG4948	Mandelate Racemase Muconate Lactonizing
IUZ65_RS20955	COG0129	dihydroxy-acid dehydratase activity
IUZ65_RS20980	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS20995	COG2376	Dihydroxyacetone kinase
IUZ65_RS21020	COG0573	inorganic phosphate transmembrane transporter activity
IUZ65_RS21025	COG0581	inorganic phosphate transmembrane transporter activity
IUZ65_RS21030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IUZ65_RS21035	COG0612	Peptidase, M16
IUZ65_RS21040	COG2188	Transcriptional regulator
IUZ65_RS21050	COG0383	alpha-mannosidase activity
IUZ65_RS21055	COG0789	Transcriptional regulator
IUZ65_RS21090	COG0714	Associated with various cellular activities
IUZ65_RS21100	COG3437	response regulator, receiver
IUZ65_RS21100	COG0784	Response regulator, receiver
IUZ65_RS21105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUZ65_RS21105	COG4191	Histidine kinase
IUZ65_RS21110	COG2354	Protein conserved in bacteria
IUZ65_RS21120	COG3123	guanosine phosphorylase activity
IUZ65_RS21125	COG1764	response to oxidative stress
IUZ65_RS21130	COG1846	Transcriptional regulator
IUZ65_RS21135	COG0179	Fumarylacetoacetate (FAA) hydrolase
IUZ65_RS21145	COG3829	transcription factor binding
IUZ65_RS21150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IUZ65_RS21155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IUZ65_RS21160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IUZ65_RS21170	COG0549	Belongs to the carbamate kinase family
IUZ65_RS21175	COG0493	'glutamate synthase
IUZ65_RS21180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IUZ65_RS21180	COG1013	pyruvate-flavodoxin oxidoreductase activity
IUZ65_RS21180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IUZ65_RS21180	COG0674	pyruvate-flavodoxin oxidoreductase activity
IUZ65_RS21185	COG2831	hemolysin activation secretion protein
IUZ65_RS21270	COG0583	DNA-binding transcription factor activity
IUZ65_RS21275	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IUZ65_RS21275	COG3608	succinylglutamate desuccinylase aspartoacylase
IUZ65_RS21280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IUZ65_RS21285	COG2068	MobA-Related Protein
IUZ65_RS21290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IUZ65_RS21290	COG0493	'glutamate synthase
IUZ65_RS21295	COG0402	S-adenosylhomocysteine deaminase activity
IUZ65_RS21310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IUZ65_RS21315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IUZ65_RS21320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IUZ65_RS21320	COG2080	2 iron, 2 sulfur cluster binding
IUZ65_RS21330	COG0402	S-adenosylhomocysteine deaminase activity
IUZ65_RS21335	COG2252	PERMEase
IUZ65_RS21350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IUZ65_RS21360	COG0668	transmembrane transport
IUZ65_RS21375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IUZ65_RS21380	COG2022	thiamine diphosphate biosynthetic process
IUZ65_RS21385	COG2104	thiamine diphosphate biosynthetic process
IUZ65_RS21390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IUZ65_RS21395	COG0352	thiamine-phosphate diphosphorylase activity
IUZ65_RS21415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IUZ65_RS21420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IUZ65_RS21420	COG0574	Belongs to the PEP-utilizing enzyme family
IUZ65_RS21435	COG2267	carboxylic ester hydrolase activity
IUZ65_RS21450	COG0583	DNA-binding transcription factor activity
IUZ65_RS21470	COG2814	Major facilitator Superfamily
IUZ65_RS21490	COG0640	Transcriptional regulator
IUZ65_RS21510	COG0583	DNA-binding transcription factor activity
IUZ65_RS21515	COG0778	Nitroreductase
IUZ65_RS21520	COG0183	Belongs to the thiolase family
IUZ65_RS21540	COG2031	fatty acid transporter
IUZ65_RS21555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUZ65_RS21575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IUZ65_RS21590	COG1477	protein flavinylation
IUZ65_RS21600	COG0583	DNA-binding transcription factor activity
IUZ65_RS21620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IUZ65_RS21625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUZ65_RS21645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IUZ65_RS21665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IUZ65_RS21665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IUZ65_RS21670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IUZ65_RS21680	COG1691	(AIR) carboxylase
IUZ65_RS21685	COG0519	Catalyzes the synthesis of GMP from XMP
IUZ65_RS21690	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IUZ65_RS21750	COG0800	Aldolase
IUZ65_RS21755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUZ65_RS21760	COG1904	glucuronate isomerase
IUZ65_RS21765	COG0246	Mannitol dehydrogenase
IUZ65_RS21780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IUZ65_RS21790	COG2186	Transcriptional regulator
IUZ65_RS21795	COG1312	Catalyzes the dehydration of D-mannonate
IUZ65_RS21800	COG4667	esterase of the alpha-beta hydrolase superfamily
IUZ65_RS21810	COG2176	DNA-directed DNA polymerase activity
IUZ65_RS21815	COG0484	heat shock protein binding
IUZ65_RS21820	COG0697	spore germination
IUZ65_RS21825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IUZ65_RS21840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IUZ65_RS21845	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IUZ65_RS21850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IUZ65_RS21855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IUZ65_RS21860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IUZ65_RS21865	COG1737	Transcriptional regulator
IUZ65_RS21870	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
IUZ65_RS21875	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
IUZ65_RS21890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IUZ65_RS21895	COG0583	DNA-binding transcription factor activity
IUZ65_RS21915	COG0577	efflux transmembrane transporter activity
IUZ65_RS21915	COG1136	(ABC) transporter
IUZ65_RS21925	COG0366	Alpha amylase catalytic
IUZ65_RS21935	COG2731	YhcH YjgK YiaL family protein
IUZ65_RS21945	COG0826	peptidase U32
IUZ65_RS21980	COG2205	protein histidine kinase activity
IUZ65_RS21980	COG0784	Response regulator, receiver
IUZ65_RS21985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IUZ65_RS21990	COG1501	Belongs to the glycosyl hydrolase 31 family
IUZ65_RS21995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IUZ65_RS22000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IUZ65_RS22010	COG0191	fructose-bisphosphate aldolase activity
IUZ65_RS22030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUZ65_RS22035	COG1349	DNA-binding transcription factor activity
IUZ65_RS22045	COG0747	negative chemotaxis
IUZ65_RS22055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IUZ65_RS22065	COG4608	Belongs to the ABC transporter superfamily
IUZ65_RS22075	COG1609	Transcriptional regulator
IUZ65_RS22120	COG1357	PFAM Pentapeptide repeats (8 copies)
IUZ65_RS22125	COG0583	DNA-binding transcription factor activity
IUZ65_RS22140	COG0789	Transcriptional regulator
IUZ65_RS22165	COG3604	Transcriptional regulator
IUZ65_RS22170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IUZ65_RS22185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IUZ65_RS22200	COG3655	Transcriptional regulator
IUZ65_RS22205	COG3842	ATPase activity
IUZ65_RS22210	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS22215	COG1175	transmembrane transport
IUZ65_RS22220	COG1653	transport
IUZ65_RS22255	COG0243	molybdopterin cofactor binding
IUZ65_RS22260	COG3005	denitrification pathway
IUZ65_RS22300	COG0384	phenazine biosynthesis protein PhzF
IUZ65_RS22305	COG3263	regulation of cellular component size
IUZ65_RS22335	COG3119	arylsulfatase activity
IUZ65_RS22340	COG0641	radical SAM
IUZ65_RS22345	COG1054	Belongs to the UPF0176 family
IUZ65_RS22360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUZ65_RS22365	COG2866	Carboxypeptidase
IUZ65_RS22375	COG0678	peroxiredoxin activity
IUZ65_RS22460	COG0509	glycine decarboxylation via glycine cleavage system
IUZ65_RS22485	COG3314	Sporulation integral membrane protein YlbJ
IUZ65_RS22495	COG0739	heme binding
IUZ65_RS22515	COG1175	transmembrane transport
IUZ65_RS22520	COG0395	ABC-type sugar transport system, permease component
IUZ65_RS22525	COG3842	ATPase activity
IUZ65_RS22565	COG0561	phosphatase activity
IUZ65_RS22570	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IUZ65_RS22575	COG3623	hexulose-6-phosphate isomerase
IUZ65_RS22595	COG1794	racemase activity, acting on amino acids and derivatives
IUZ65_RS22605	COG0765	amino acid transport
IUZ65_RS22610	COG0765	amino acid transport
IUZ65_RS22615	COG1126	abc transporter atp-binding protein
IUZ65_RS22620	COG1446	asparaginase
IUZ65_RS22625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUZ65_RS22630	COG1609	Transcriptional regulator
IUZ65_RS22670	COG0302	gtp cyclohydrolase
IUZ65_RS22685	COG0840	transmembrane signaling receptor activity
IUZ65_RS22695	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS22705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUZ65_RS22720	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IUZ65_RS22725	COG0494	nUDIX hydrolase
IUZ65_RS22735	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IUZ65_RS22745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IUZ65_RS22760	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IUZ65_RS22765	COG0513	Belongs to the DEAD box helicase family
IUZ65_RS22775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IUZ65_RS22780	COG5001	Diguanylate cyclase
IUZ65_RS22790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IUZ65_RS22795	COG2213	PTS system mannitol-specific
IUZ65_RS22795	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUZ65_RS22800	COG0246	Mannitol dehydrogenase
IUZ65_RS22805	COG3722	fumarate hydratase activity
IUZ65_RS22810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IUZ65_RS22815	COG0038	chloride channel
IUZ65_RS22820	COG0523	cobalamin synthesis protein
IUZ65_RS22835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IUZ65_RS22840	COG0363	glucosamine-6-phosphate deaminase activity
IUZ65_RS22845	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IUZ65_RS22850	COG2199	diguanylate cyclase activity
IUZ65_RS22860	COG0725	ABC transporter, periplasmic molybdate-binding protein
IUZ65_RS22865	COG4149	molybdate abc transporter
IUZ65_RS22870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IUZ65_RS22885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IUZ65_RS22890	COG2095	MarC family integral membrane protein
IUZ65_RS22910	COG0640	Transcriptional regulator
IUZ65_RS22925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUZ65_RS22940	COG1070	Carbohydrate kinase
IUZ65_RS22945	COG1063	alcohol dehydrogenase
IUZ65_RS22960	COG1129	ABC transporter
IUZ65_RS22965	COG1172	Belongs to the binding-protein-dependent transport system permease family
IUZ65_RS22970	COG0656	L-ascorbic acid biosynthetic process
IUZ65_RS22980	COG1349	DNA-binding transcription factor activity
IUZ65_RS22990	COG1328	CTP reductase activity
IUZ65_RS22995	COG0602	queuosine metabolic process
IUZ65_RS23010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IUZ65_RS23015	COG2030	dehydratase
IUZ65_RS23020	COG4670	ketone body catabolic process
IUZ65_RS23025	COG0583	DNA-binding transcription factor activity
IUZ65_RS23030	COG1028	Short-chain dehydrogenase reductase Sdr
IUZ65_RS23035	COG0183	Belongs to the thiolase family
IUZ65_RS23060	COG4067	protein conserved in archaea
IUZ65_RS23060	COG0189	ligase activity
IUZ65_RS23075	COG5001	Diguanylate cyclase
IUZ65_RS23075	COG1716	ATPase activity
IUZ65_RS23080	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IUZ65_RS23090	COG4181	ATPase activity
IUZ65_RS23095	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IUZ65_RS23105	COG1984	allophanate hydrolase subunit 2
IUZ65_RS23110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IUZ65_RS23120	COG1042	CoA-binding domain protein
IUZ65_RS23120	COG0045	succinate-CoA ligase (ADP-forming) activity
IUZ65_RS23120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IUZ65_RS23130	COG1181	Belongs to the D-alanine--D-alanine ligase family
IUZ65_RS23145	COG0023	Translation Initiation Factor
IUZ65_RS23150	COG0346	lactoylglutathione lyase activity
IUZ65_RS23165	COG1132	(ABC) transporter
IUZ65_RS23170	COG1132	(ABC) transporter
IUZ65_RS23185	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IUZ65_RS23190	COG5001	Diguanylate cyclase
IUZ65_RS23190	COG4251	negative regulation of phosphorylation
IUZ65_RS23190	COG2203	Gaf domain
IUZ65_RS23190	COG3706	GGDEF domain
IUZ65_RS23195	COG0402	S-adenosylhomocysteine deaminase activity
IUZ65_RS23200	COG2199	diguanylate cyclase activity
IUZ65_RS23205	COG3140	Belongs to the UPF0181 family
IUZ65_RS23230	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IUZ65_RS23235	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IUZ65_RS23290	COG2050	protein possibly involved in aromatic compounds catabolism
IUZ65_RS23315	COG0737	Belongs to the 5'-nucleotidase family
IUZ65_RS23320	COG3593	DNA synthesis involved in DNA repair
IUZ65_RS23330	COG0583	DNA-binding transcription factor activity
IUZ65_RS23335	COG2116	formate transmembrane transporter activity
IUZ65_RS23340	COG2353	YceI-like domain
IUZ65_RS23345	COG3038	cytochrome b561
IUZ65_RS23375	COG3287	FIST C domain
IUZ65_RS23375	COG2200	EAL domain
IUZ65_RS23375	COG2199	diguanylate cyclase activity
IUZ65_RS23390	COG2207	Transcriptional regulator
IUZ65_RS23390	COG0662	Cupin 2, conserved barrel domain protein
IUZ65_RS23420	COG2165	general secretion pathway protein
IUZ65_RS23460	COG2165	general secretion pathway protein