locus-tag	class	description
GZI12_RS00020	COG1126	abc transporter atp-binding protein
GZI12_RS00030	COG0594	ribonuclease P activity
GZI12_RS00050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GZI12_RS00055	COG0445	tRNA wobble uridine modification
GZI12_RS00065	COG1192	Involved in chromosome partitioning
GZI12_RS00075	COG3312	ion transport
GZI12_RS00090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GZI12_RS00095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZI12_RS00100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GZI12_RS00105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZI12_RS00110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GZI12_RS00115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GZI12_RS00125	COG2814	Major facilitator Superfamily
GZI12_RS00130	COG0583	DNA-binding transcription factor activity
GZI12_RS00135	COG0183	Belongs to the thiolase family
GZI12_RS00145	COG1739	Uncharacterized protein family UPF0029
GZI12_RS00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZI12_RS00270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GZI12_RS00275	COG0352	thiamine-phosphate diphosphorylase activity
GZI12_RS00280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GZI12_RS00295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GZI12_RS00300	COG0006	proline dipeptidase activity
GZI12_RS00320	COG1522	sequence-specific DNA binding
GZI12_RS00330	COG0742	ribosomal rna small subunit methyltransferase
GZI12_RS00345	COG0589	response to stress
GZI12_RS00350	COG1528	Iron-storage protein
GZI12_RS00360	COG2081	HI0933 family
GZI12_RS00365	COG1609	Transcriptional regulator
GZI12_RS00370	COG0129	dihydroxy-acid dehydratase activity
GZI12_RS00375	COG3265	gluconokinase activity
GZI12_RS00380	COG2610	gluconate transmembrane transporter activity
GZI12_RS00385	COG0800	Aldolase
GZI12_RS00395	COG1322	Protein conserved in bacteria
GZI12_RS00400	COG2226	methyltransferase
GZI12_RS00410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GZI12_RS00420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZI12_RS00425	COG0805	protein transport
GZI12_RS00430	COG0084	hydrolase, TatD family'
GZI12_RS00440	COG0456	acetyltransferase
GZI12_RS00480	COG0583	DNA-binding transcription factor activity
GZI12_RS00485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GZI12_RS00490	COG2960	long-chain fatty acid transporting porin activity
GZI12_RS00495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZI12_RS00500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZI12_RS00505	COG1309	transcriptional regulator
GZI12_RS00510	COG0210	DNA helicase
GZI12_RS00550	COG4166	transmembrane transport
GZI12_RS00560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZI12_RS00565	COG2194	sulfuric ester hydrolase activity
GZI12_RS00575	COG2814	Major facilitator Superfamily
GZI12_RS00580	COG1566	PFAM secretion protein HlyD family protein
GZI12_RS00590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZI12_RS00595	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GZI12_RS00600	COG0339	signal peptide processing
GZI12_RS00615	COG3220	belongs to the UPF0276 family
GZI12_RS00625	COG0210	DNA helicase
GZI12_RS00640	COG2962	Rard protein
GZI12_RS00645	COG0514	ATP-dependent DNA helicase (RecQ)
GZI12_RS00655	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GZI12_RS00660	COG0248	Ppx GppA phosphatase
GZI12_RS00670	COG3118	belongs to the thioredoxin family
GZI12_RS00685	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GZI12_RS00735	COG3071	HemY protein
GZI12_RS00740	COG2959	enzyme of heme biosynthesis
GZI12_RS00745	COG1587	Uroporphyrinogen-III synthase
GZI12_RS00770	COG0019	diaminopimelate decarboxylase activity
GZI12_RS00775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GZI12_RS00785	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GZI12_RS00790	COG1011	Hydrolase
GZI12_RS00810	COG0561	phosphatase activity
GZI12_RS00815	COG2267	carboxylic ester hydrolase activity
GZI12_RS00820	COG1280	lysine exporter protein (LysE YggA)
GZI12_RS00825	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GZI12_RS00830	COG0640	Transcriptional regulator
GZI12_RS00835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GZI12_RS00875	COG2095	MarC family integral membrane protein
GZI12_RS00885	COG0742	ribosomal rna small subunit methyltransferase
GZI12_RS00890	COG0552	protein localization to endoplasmic reticulum
GZI12_RS00895	COG2884	Cell division ATP-binding protein ftsE
GZI12_RS00900	COG2177	Part of the ABC transporter FtsEX involved in
GZI12_RS00910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZI12_RS00915	COG0705	Rhomboid family
GZI12_RS00920	COG1580	Controls the rotational direction of flagella during chemotaxis
GZI12_RS00935	COG2937	Belongs to the GPAT DAPAT family
GZI12_RS00940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GZI12_RS00945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GZI12_RS00955	COG0534	Mate efflux family protein
GZI12_RS00975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GZI12_RS01050	COG1573	uracil-dna glycosylase
GZI12_RS01055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZI12_RS01065	COG1253	flavin adenine dinucleotide binding
GZI12_RS01080	COG0151	Belongs to the GarS family
GZI12_RS01085	COG0138	bifunctional purine biosynthesis protein purh
GZI12_RS01090	COG0789	Transcriptional regulator
GZI12_RS01095	COG3706	GGDEF domain
GZI12_RS01100	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GZI12_RS01105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZI12_RS01110	COG2264	protein methyltransferase activity
GZI12_RS01115	COG0439	Biotin carboxylase
GZI12_RS01120	COG0511	ligase activity, forming carbon-carbon bonds
GZI12_RS01125	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GZI12_RS01130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZI12_RS01145	COG2814	Major facilitator Superfamily
GZI12_RS01150	COG0784	Response regulator, receiver
GZI12_RS01150	COG2198	Histidine kinase
GZI12_RS01150	COG2205	protein histidine kinase activity
GZI12_RS01160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZI12_RS01170	COG2095	MarC family integral membrane protein
GZI12_RS01190	COG1027	Aspartate ammonia-lyase
GZI12_RS01200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GZI12_RS01205	COG2205	protein histidine kinase activity
GZI12_RS01210	COG0745	RESPONSE REGULATOR receiver
GZI12_RS01235	COG1509	lysine 2,3-aminomutase activity
GZI12_RS01245	COG1575	Belongs to the MenA family. Type 1 subfamily
GZI12_RS01250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GZI12_RS01255	COG0534	Mate efflux family protein
GZI12_RS01260	COG0149	triose-phosphate isomerase activity
GZI12_RS01270	COG1072	(Pantothenic acid kinase))
GZI12_RS01300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZI12_RS01305	COG0250	Participates in transcription elongation, termination and antitermination
GZI12_RS01315	COG0081	regulation of translation
GZI12_RS01320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GZI12_RS01330	COG0085	RNA polymerase activity
GZI12_RS01335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZI12_RS01340	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GZI12_RS01365	COG4942	peptidase
GZI12_RS01370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GZI12_RS01380	COG0490	domain, Protein
GZI12_RS01380	COG0471	metal ion transport
GZI12_RS01385	COG0688	phosphatidylethanolamine metabolic process
GZI12_RS01390	COG1162	GTPase activity
GZI12_RS01395	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GZI12_RS01475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GZI12_RS01480	COG0802	atpase or kinase
GZI12_RS01490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GZI12_RS01500	COG1923	regulation of RNA biosynthetic process
GZI12_RS01505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GZI12_RS01510	COG0330	HflC and HflK could
GZI12_RS01515	COG0330	HflC and HflK could
GZI12_RS01520	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GZI12_RS01535	COG0545	Peptidyl-prolyl cis-trans isomerase
GZI12_RS01540	COG2964	Protein conserved in bacteria
GZI12_RS01545	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GZI12_RS01550	COG2923	Belongs to the DsrF TusC family
GZI12_RS01565	COG0049	tRNA binding
GZI12_RS01570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZI12_RS01580	COG2906	2 iron, 2 sulfur cluster binding
GZI12_RS01595	COG2965	DNA replication, synthesis of RNA primer
GZI12_RS01620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GZI12_RS01625	COG0432	Pfam Uncharacterised protein family UPF0047
GZI12_RS01645	COG0577	efflux transmembrane transporter activity
GZI12_RS01645	COG1136	(ABC) transporter
GZI12_RS01665	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GZI12_RS01670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZI12_RS01680	COG2911	Protein conserved in bacteria
GZI12_RS01685	COG2105	PFAM AIG2 family protein
GZI12_RS01695	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GZI12_RS01705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GZI12_RS01710	COG0163	prenyltransferase activity
GZI12_RS01715	COG4143	(ABC) transporter
GZI12_RS01720	COG1178	ABC-type Fe3 transport system permease component
GZI12_RS01725	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GZI12_RS01730	COG3028	Belongs to the UPF0307 family
GZI12_RS01735	COG0312	modulator of DNA gyrase
GZI12_RS01740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GZI12_RS01745	COG1678	Uncharacterized ACR, COG1678
GZI12_RS01750	COG0189	ligase activity
GZI12_RS01755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GZI12_RS01760	COG2356	endonuclease I
GZI12_RS01765	COG3091	SprT-like family
GZI12_RS01775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GZI12_RS01780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GZI12_RS01785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GZI12_RS01790	COG0126	phosphoglycerate kinase activity
GZI12_RS01795	COG0191	fructose-bisphosphate aldolase activity
GZI12_RS01800	COG0668	transmembrane transport
GZI12_RS01805	COG1279	arginine transmembrane transporter activity
GZI12_RS01810	COG0583	DNA-binding transcription factor activity
GZI12_RS01825	COG0469	pyruvate kinase activity
GZI12_RS01830	COG1349	DNA-binding transcription factor activity
GZI12_RS01835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GZI12_RS01840	COG3722	fumarate hydratase activity
GZI12_RS01850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS01850	COG2213	PTS system mannitol-specific
GZI12_RS01865	COG2252	PERMEase
GZI12_RS01885	COG0358	DNA primase activity
GZI12_RS01890	COG1610	YqeY-like protein
GZI12_RS01895	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GZI12_RS01900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZI12_RS01905	COG0596	Alpha beta hydrolase
GZI12_RS01910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZI12_RS01915	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GZI12_RS01920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZI12_RS01930	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GZI12_RS01935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GZI12_RS01945	COG0585	pseudouridine synthase activity
GZI12_RS01950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GZI12_RS01965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZI12_RS01970	COG4536	flavin adenine dinucleotide binding
GZI12_RS01975	COG4137	Cytochrome C assembly protein
GZI12_RS01980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GZI12_RS01985	COG0228	four-way junction DNA binding
GZI12_RS02000	COG0335	large ribosomal subunit rRNA binding
GZI12_RS02005	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GZI12_RS02010	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GZI12_RS02015	COG0237	dephospho-CoA kinase activity
GZI12_RS02025	COG1459	type II secretion system
GZI12_RS02030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GZI12_RS02035	COG4969	Belongs to the N-Me-Phe pilin family
GZI12_RS02040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GZI12_RS02050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GZI12_RS02055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZI12_RS02060	COG0527	aspartate kinase activity
GZI12_RS02120	COG0511	ligase activity, forming carbon-carbon bonds
GZI12_RS02120	COG5016	pyruvate
GZI12_RS02125	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GZI12_RS02130	COG1063	alcohol dehydrogenase
GZI12_RS02135	COG1238	metal cluster binding
GZI12_RS02140	COG0612	Peptidase, M16
GZI12_RS02155	COG1854	S-ribosylhomocysteine lyase activity
GZI12_RS02170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZI12_RS02175	COG1446	asparaginase
GZI12_RS02180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZI12_RS02185	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZI12_RS02200	COG1301	dicarboxylic acid transport
GZI12_RS02215	COG1486	melibiose metabolic process
GZI12_RS02220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS02220	COG1263	PTS System
GZI12_RS02225	COG2188	Transcriptional regulator
GZI12_RS02280	COG0473	3-isopropylmalate dehydrogenase activity
GZI12_RS02285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZI12_RS02300	COG1022	Amp-dependent synthetase and ligase
GZI12_RS02305	COG0028	Belongs to the TPP enzyme family
GZI12_RS02315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZI12_RS02320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GZI12_RS02325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GZI12_RS02345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZI12_RS02350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZI12_RS02370	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GZI12_RS02380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GZI12_RS02385	COG1595	DNA-templated transcription, initiation
GZI12_RS02395	COG3026	antisigma factor binding
GZI12_RS02400	COG3086	response to oxidative stress
GZI12_RS02405	COG0481	GTPase activity
GZI12_RS02420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GZI12_RS02425	COG1381	Involved in DNA repair and RecF pathway recombination
GZI12_RS02430	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GZI12_RS02440	COG2205	protein histidine kinase activity
GZI12_RS02440	COG3437	response regulator, receiver
GZI12_RS02440	COG3850	Histidine kinase
GZI12_RS02440	COG4999	Histidine kinase
GZI12_RS02450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GZI12_RS02455	COG3956	TIGRFAM MazG family protein
GZI12_RS02460	COG0504	CTP synthase activity
GZI12_RS02465	COG0148	phosphopyruvate hydratase activity
GZI12_RS02475	COG3409	Peptidoglycan-binding domain 1 protein
GZI12_RS02475	COG3267	Type II secretory pathway component ExeA
GZI12_RS02485	COG4991	sh3 domain protein
GZI12_RS02490	COG0306	phosphate transporter
GZI12_RS02495	COG1392	Phosphate transport regulator
GZI12_RS02500	COG3025	triphosphatase activity
GZI12_RS02515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GZI12_RS02525	COG0745	RESPONSE REGULATOR receiver
GZI12_RS02535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GZI12_RS02550	COG0083	homoserine kinase activity
GZI12_RS02555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GZI12_RS02560	COG2860	membrane
GZI12_RS02565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZI12_RS02580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GZI12_RS02585	COG1185	polyribonucleotide nucleotidyltransferase activity
GZI12_RS02600	COG0534	Mate efflux family protein
GZI12_RS02610	COG0737	Belongs to the 5'-nucleotidase family
GZI12_RS02615	COG0826	peptidase U32
GZI12_RS02620	COG0826	peptidase U32
GZI12_RS02630	COG3154	lipid carrier protein
GZI12_RS02635	COG3153	acetyltransferase
GZI12_RS02645	COG0456	acetyltransferase
GZI12_RS02650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GZI12_RS02655	COG0513	Belongs to the DEAD box helicase family
GZI12_RS02660	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GZI12_RS02695	COG0069	glutamate synthase activity
GZI12_RS02695	COG0067	glutamate synthase
GZI12_RS02695	COG0070	glutamate synthase
GZI12_RS02700	COG1242	4 iron, 4 sulfur cluster binding
GZI12_RS02705	COG5001	Diguanylate cyclase
GZI12_RS02705	COG4251	negative regulation of phosphorylation
GZI12_RS02705	COG3706	GGDEF domain
GZI12_RS02705	COG2203	Gaf domain
GZI12_RS02710	COG0784	Response regulator, receiver
GZI12_RS02710	COG2198	Histidine kinase
GZI12_RS02710	COG5002	protein histidine kinase activity
GZI12_RS02735	COG3066	DNA modification
GZI12_RS02740	COG0494	nUDIX hydrolase
GZI12_RS02750	COG0730	response to heat
GZI12_RS02760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GZI12_RS02765	COG1283	sodium-dependent phosphate transmembrane transporter activity
GZI12_RS02770	COG0583	DNA-binding transcription factor activity
GZI12_RS02775	COG0268	Binds directly to 16S ribosomal RNA
GZI12_RS02780	COG0728	peptidoglycan biosynthetic process
GZI12_RS02785	COG0196	riboflavin kinase activity
GZI12_RS02800	COG1047	Peptidyl-prolyl cis-trans
GZI12_RS02805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GZI12_RS02820	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GZI12_RS02835	COG1605	Chorismate mutase
GZI12_RS02835	COG0287	Prephenate dehydrogenase
GZI12_RS02850	COG0488	(ABC) transporter
GZI12_RS02860	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GZI12_RS02865	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GZI12_RS02885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GZI12_RS02900	COG0564	pseudouridine synthase activity
GZI12_RS02955	COG0483	inositol monophosphate 1-phosphatase activity
GZI12_RS02960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GZI12_RS02970	COG1104	cysteine desulfurase activity
GZI12_RS02975	COG0822	iron-sulfur transferase activity
GZI12_RS02980	COG0316	Belongs to the HesB IscA family
GZI12_RS02990	COG0443	Heat shock 70 kDa protein
GZI12_RS02995	COG0633	Ferredoxin
GZI12_RS03000	COG2975	iron-sulfur cluster assembly
GZI12_RS03010	COG0105	UTP biosynthetic process
GZI12_RS03015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZI12_RS03020	COG0693	protein deglycase activity
GZI12_RS03025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GZI12_RS03040	COG1595	DNA-templated transcription, initiation
GZI12_RS03055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZI12_RS03065	COG2813	Specifically methylates the guanine in position
GZI12_RS03070	COG0271	Belongs to the BolA IbaG family
GZI12_RS03075	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GZI12_RS03080	COG1805	sodium ion transport
GZI12_RS03100	COG2871	sodium ion transport
GZI12_RS03105	COG1477	protein flavinylation
GZI12_RS03110	COG2991	Protein conserved in bacteria
GZI12_RS03120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZI12_RS03135	COG0733	neurotransmitter:sodium symporter activity
GZI12_RS03155	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZI12_RS03160	COG2252	PERMEase
GZI12_RS03165	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GZI12_RS03185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GZI12_RS03195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZI12_RS03195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZI12_RS03215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZI12_RS03225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GZI12_RS03235	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GZI12_RS03240	COG0024	Methionine aminopeptidase
GZI12_RS03250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GZI12_RS03255	COG0528	UMP kinase activity
GZI12_RS03265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GZI12_RS03270	COG0575	Belongs to the CDS family
GZI12_RS03275	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GZI12_RS03280	COG0750	zinc metalloprotease
GZI12_RS03290	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GZI12_RS03295	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GZI12_RS03300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GZI12_RS03310	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GZI12_RS03320	COG0587	DNA-directed DNA polymerase activity
GZI12_RS03325	COG0825	malonyl-CoA metabolic process
GZI12_RS03330	COG0037	tRNA processing
GZI12_RS03335	COG0347	Belongs to the P(II) protein family
GZI12_RS03340	COG3021	interspecies interaction between organisms
GZI12_RS03350	COG0741	lytic transglycosylase activity
GZI12_RS03350	COG1388	LysM domain
GZI12_RS03360	COG2226	methyltransferase
GZI12_RS03365	COG0328	RNA-DNA hybrid ribonuclease activity
GZI12_RS03370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZI12_RS03380	COG1960	acyl-CoA dehydrogenase activity
GZI12_RS03385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GZI12_RS03390	COG0121	glutamine amidotransferase
GZI12_RS03405	COG1720	tRNA m6t6A37 methyltransferase activity
GZI12_RS03415	COG1464	Belongs to the NlpA lipoprotein family
GZI12_RS03430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GZI12_RS03445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZI12_RS03455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GZI12_RS03465	COG2921	Belongs to the UPF0250 family
GZI12_RS03470	COG1686	Belongs to the peptidase S11 family
GZI12_RS03475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GZI12_RS03480	COG0772	Belongs to the SEDS family
GZI12_RS03485	COG0768	penicillin binding
GZI12_RS03495	COG0799	negative regulation of ribosome biogenesis
GZI12_RS03500	COG1466	dna polymerase III delta subunit
GZI12_RS03505	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GZI12_RS03510	COG0495	leucyl-tRNA aminoacylation
GZI12_RS03515	COG2888	peptidyl-tyrosine sulfation
GZI12_RS03520	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GZI12_RS03525	COG4535	Mg2 and Co2 transporter CorC
GZI12_RS03530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GZI12_RS03535	COG1702	phosphate starvation-inducible protein PhoH
GZI12_RS03540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZI12_RS03545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZI12_RS03550	COG2190	(PTS) system
GZI12_RS03555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZI12_RS03560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS03565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZI12_RS03575	COG3115	cell septum assembly
GZI12_RS03595	COG1585	Membrane protein implicated in regulation of membrane protease activity
GZI12_RS03600	COG0330	HflC and HflK could
GZI12_RS03605	COG3118	belongs to the thioredoxin family
GZI12_RS03610	COG0300	oxidoreductase activity
GZI12_RS03615	COG1090	epimerase
GZI12_RS03640	COG0622	Phosphoesterase
GZI12_RS03660	COG3710	Transcriptional regulator
GZI12_RS03665	COG0326	Molecular chaperone. Has ATPase activity
GZI12_RS03675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GZI12_RS03685	COG2217	Heavy metal translocating P-type atpase
GZI12_RS03685	COG2608	mercury ion transmembrane transporter activity
GZI12_RS03690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZI12_RS03730	COG2747	anti-sigma28 factor FlgM
GZI12_RS03740	COG0835	chemotaxis
GZI12_RS03740	COG0784	Response regulator, receiver
GZI12_RS03745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GZI12_RS03750	COG1815	bacterial-type flagellum-dependent cell motility
GZI12_RS03765	COG1749	Flagellar hook protein flgE
GZI12_RS03770	COG4787	bacterial-type flagellum-dependent cell motility
GZI12_RS03780	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GZI12_RS03790	COG1705	Flagellar rod assembly protein muramidase FlgJ
GZI12_RS03790	COG3951	Flagellar rod assembly protein muramidase FlgJ
GZI12_RS03800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZI12_RS03950	COG0193	aminoacyl-tRNA hydrolase activity
GZI12_RS03955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZI12_RS03965	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GZI12_RS03970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GZI12_RS03980	COG2890	protein-(glutamine-N5) methyltransferase activity
GZI12_RS03985	COG3094	Invasion gene expression up-regulator, SirB
GZI12_RS03995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GZI12_RS04005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GZI12_RS04030	COG1393	Belongs to the ArsC family
GZI12_RS04035	COG4783	chaperone-mediated protein folding
GZI12_RS04055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GZI12_RS04060	COG2716	regulation of RNA biosynthetic process
GZI12_RS04065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZI12_RS04075	COG2056	Na+-H+ antiporter family
GZI12_RS04095	COG0346	lactoylglutathione lyase activity
GZI12_RS04100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GZI12_RS04105	COG4660	Part of a membrane complex involved in electron transport
GZI12_RS04110	COG4659	FMN binding
GZI12_RS04120	COG4656	Part of a membrane complex involved in electron transport
GZI12_RS04125	COG2878	Part of a membrane complex involved in electron transport
GZI12_RS04130	COG4657	Part of a membrane complex involved in electron transport
GZI12_RS04135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GZI12_RS04145	COG0556	nucleotide-excision repair
GZI12_RS04150	COG2204	response regulator
GZI12_RS04155	COG2198	Histidine kinase
GZI12_RS04160	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GZI12_RS04165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GZI12_RS04170	COG0521	Mo-molybdopterin cofactor biosynthetic process
GZI12_RS04175	COG0315	cyclic pyranopterin monophosphate synthase activity
GZI12_RS04180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GZI12_RS04185	COG0314	molybdopterin synthase activity
GZI12_RS04190	COG0617	tRNA 3'-terminal CCA addition
GZI12_RS04190	COG0517	IMP dehydrogenase activity
GZI12_RS04190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GZI12_RS04220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZI12_RS04220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZI12_RS04225	COG0489	protein tyrosine kinase activity
GZI12_RS04230	COG0572	uridine kinase
GZI12_RS04235	COG2982	Protein involved in outer membrane biogenesis
GZI12_RS04240	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GZI12_RS04250	COG0356	it plays a direct role in the translocation of protons across the membrane
GZI12_RS04265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZI12_RS04275	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZI12_RS04285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GZI12_RS04290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GZI12_RS04310	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GZI12_RS04315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZI12_RS04325	COG0123	including yeast histone deacetylase and acetoin utilization protein
GZI12_RS04330	COG5001	Diguanylate cyclase
GZI12_RS04335	COG2186	Transcriptional regulator
GZI12_RS04345	COG2721	sulfolactate sulfo-lyase activity
GZI12_RS04355	COG4948	Mandelate Racemase Muconate Lactonizing
GZI12_RS04360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZI12_RS04375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GZI12_RS04375	COG1648	precorrin-2 dehydrogenase activity
GZI12_RS04405	COG3082	Protein of unknown function (DUF1414)
GZI12_RS04420	COG1757	Na H antiporter
GZI12_RS04425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZI12_RS04430	COG2186	Transcriptional regulator
GZI12_RS04435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZI12_RS04440	COG2095	MarC family integral membrane protein
GZI12_RS04445	COG1454	alcohol dehydrogenase
GZI12_RS04445	COG1012	belongs to the aldehyde dehydrogenase family
GZI12_RS04450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GZI12_RS04455	COG2894	cell division
GZI12_RS04460	COG0850	regulation of cytokinetic process
GZI12_RS04470	COG2951	lytic endotransglycosylase activity
GZI12_RS04475	COG0583	DNA-binding transcription factor activity
GZI12_RS04480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZI12_RS04485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GZI12_RS04510	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZI12_RS04545	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GZI12_RS04550	COG0443	Heat shock 70 kDa protein
GZI12_RS04555	COG0625	glutathione transferase activity
GZI12_RS04580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZI12_RS04590	COG0848	biopolymer transport protein
GZI12_RS04595	COG0811	peptide transport
GZI12_RS04600	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GZI12_RS04610	COG3721	Heme iron utilization protein
GZI12_RS04615	COG0748	coenzyme F420 binding
GZI12_RS04620	COG4771	TonB-dependent receptor
GZI12_RS04625	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZI12_RS04635	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GZI12_RS04645	COG0776	regulation of translation
GZI12_RS04655	COG1555	photosystem II stabilization
GZI12_RS04660	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GZI12_RS04665	COG0539	negative regulation of cytoplasmic translation
GZI12_RS04675	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GZI12_RS04680	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GZI12_RS04700	COG0583	DNA-binding transcription factor activity
GZI12_RS04715	COG4120	Belongs to the binding-protein-dependent transport system permease family
GZI12_RS04725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZI12_RS04735	COG3318	Belongs to the UPF0149 family
GZI12_RS04735	COG3012	SEC-C Motif Domain Protein
GZI12_RS04740	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GZI12_RS04745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GZI12_RS04765	COG3047	cAMP biosynthetic process
GZI12_RS04770	COG0252	asparaginase activity
GZI12_RS04775	COG0616	signal peptide processing
GZI12_RS04780	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZI12_RS04780	COG1902	pentaerythritol trinitrate reductase activity
GZI12_RS04790	COG0788	formyltetrahydrofolate deformylase activity
GZI12_RS04800	COG1199	ATP-dependent helicase activity
GZI12_RS04805	COG1214	PFAM Peptidase M22, glycoprotease
GZI12_RS04820	COG0596	Alpha beta hydrolase
GZI12_RS04825	COG0318	PFAM AMP-dependent synthetase and ligase
GZI12_RS04830	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GZI12_RS04835	COG0513	Belongs to the DEAD box helicase family
GZI12_RS04840	COG0659	secondary active sulfate transmembrane transporter activity
GZI12_RS04845	COG1530	ribonuclease E activity
GZI12_RS04850	COG0564	pseudouridine synthase activity
GZI12_RS04855	COG0424	maF-like protein
GZI12_RS04860	COG1399	metal-binding, possibly nucleic acid-binding protein
GZI12_RS04865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GZI12_RS04875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZI12_RS04900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZI12_RS04905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GZI12_RS04910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZI12_RS04915	COG0470	DNA polymerase III
GZI12_RS04920	COG0084	hydrolase, TatD family'
GZI12_RS04925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS04925	COG1263	PTS System
GZI12_RS04955	COG4667	esterase of the alpha-beta hydrolase superfamily
GZI12_RS04965	COG0784	Response regulator, receiver
GZI12_RS04965	COG0835	chemotaxis
GZI12_RS04985	COG1028	Short-chain dehydrogenase reductase Sdr
GZI12_RS04990	COG0616	signal peptide processing
GZI12_RS05000	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GZI12_RS05020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS05025	COG3716	PTS system mannose fructose sorbose family IID component
GZI12_RS05035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS05040	COG2222	sugar isomerase
GZI12_RS05050	COG1349	DNA-binding transcription factor activity
GZI12_RS05060	COG1349	DNA-binding transcription factor activity
GZI12_RS05075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZI12_RS05080	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GZI12_RS05100	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GZI12_RS05105	COG0436	Aminotransferase
GZI12_RS05110	COG1169	isochorismate synthase
GZI12_RS05115	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GZI12_RS05120	COG2267	carboxylic ester hydrolase activity
GZI12_RS05125	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GZI12_RS05140	COG2855	membrane
GZI12_RS05145	COG0477	Major facilitator Superfamily
GZI12_RS05170	COG1946	Acyl-CoA thioesterase
GZI12_RS05190	COG3300	MHYT domain
GZI12_RS05190	COG5001	Diguanylate cyclase
GZI12_RS05215	COG1418	mRNA catabolic process
GZI12_RS05220	COG3064	Membrane
GZI12_RS05235	COG0784	Response regulator, receiver
GZI12_RS05235	COG2205	protein histidine kinase activity
GZI12_RS05240	COG0583	DNA-binding transcription factor activity
GZI12_RS05245	COG4221	oxidoreductase activity
GZI12_RS05255	COG0601	transmembrane transport
GZI12_RS05260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZI12_RS05265	COG0444	Belongs to the ABC transporter superfamily
GZI12_RS05275	COG0435	Glutathione S-transferase
GZI12_RS05300	COG3174	membrane
GZI12_RS05305	COG0857	belongs to the CobB CobQ family
GZI12_RS05305	COG0280	phosphate acetyltransferase
GZI12_RS05315	COG3092	negative regulation of chromosome organization
GZI12_RS05320	COG0686	Belongs to the AlaDH PNT family
GZI12_RS05325	COG1522	sequence-specific DNA binding
GZI12_RS05330	COG1674	ftsk spoiiie
GZI12_RS05340	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GZI12_RS05345	COG2186	Transcriptional regulator
GZI12_RS05350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GZI12_RS05355	COG1151	hydroxylamine reductase activity
GZI12_RS05360	COG3604	Transcriptional regulator
GZI12_RS05370	COG0840	transmembrane signaling receptor activity
GZI12_RS05375	COG0537	adenosine 5'-monophosphoramidase activity
GZI12_RS05400	COG3150	esterase
GZI12_RS05405	COG1252	NADH dehydrogenase
GZI12_RS05420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GZI12_RS05430	COG4591	ABC-type transport system involved in lipoprotein release permease component
GZI12_RS05435	COG1136	(ABC) transporter
GZI12_RS05440	COG4591	ABC-type transport system involved in lipoprotein release permease component
GZI12_RS05450	COG0658	competence protein
GZI12_RS05450	COG2333	competence protein COMEC
GZI12_RS05455	COG1132	(ABC) transporter
GZI12_RS05470	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GZI12_RS05480	COG3005	denitrification pathway
GZI12_RS05490	COG0243	molybdopterin cofactor binding
GZI12_RS05500	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
GZI12_RS05500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GZI12_RS05510	COG2197	response regulator
GZI12_RS05515	COG2719	SpoVR family
GZI12_RS05520	COG2718	Belongs to the UPF0229 family
GZI12_RS05525	COG2766	serine protein kinase
GZI12_RS05550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GZI12_RS05560	COG1882	Formate acetyltransferase
GZI12_RS05575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZI12_RS05585	COG4160	amino acid transport
GZI12_RS05595	COG3275	phosphorelay sensor kinase activity
GZI12_RS05610	COG4591	ABC-type transport system involved in lipoprotein release permease component
GZI12_RS05615	COG1136	(ABC) transporter
GZI12_RS05635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GZI12_RS05645	COG0443	Heat shock 70 kDa protein
GZI12_RS05650	COG0443	Heat shock 70 kDa protein
GZI12_RS05660	COG5001	Diguanylate cyclase
GZI12_RS05670	COG0840	transmembrane signaling receptor activity
GZI12_RS05695	COG1643	Atp-dependent helicase
GZI12_RS05710	COG4589	Belongs to the CDS family
GZI12_RS05725	COG1301	dicarboxylic acid transport
GZI12_RS05730	COG0159	tryptophan synthase activity
GZI12_RS05735	COG0133	tryptophan synthase activity
GZI12_RS05740	COG0134	indole-3-glycerol-phosphate synthase activity
GZI12_RS05740	COG0135	phosphoribosylanthranilate isomerase activity
GZI12_RS05745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GZI12_RS05750	COG0512	Glutamine amidotransferase of anthranilate synthase
GZI12_RS05755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GZI12_RS05765	COG0613	PHP domain protein
GZI12_RS05770	COG0009	L-threonylcarbamoyladenylate synthase
GZI12_RS05775	COG1187	pseudouridine synthase activity
GZI12_RS05785	COG3437	response regulator, receiver
GZI12_RS05795	COG3706	GGDEF domain
GZI12_RS05805	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GZI12_RS05810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GZI12_RS05815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZI12_RS05835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZI12_RS05840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GZI12_RS05845	COG1012	belongs to the aldehyde dehydrogenase family
GZI12_RS05850	COG1522	sequence-specific DNA binding
GZI12_RS05855	COG0006	proline dipeptidase activity
GZI12_RS05860	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GZI12_RS05865	COG4988	ABC transporter
GZI12_RS05870	COG0492	ferredoxin-NADP+ reductase activity
GZI12_RS05880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZI12_RS05895	COG2949	membrane
GZI12_RS05905	COG0281	malic enzyme
GZI12_RS05920	COG1448	Aminotransferase
GZI12_RS05930	COG0017	Asparaginyl-tRNA synthetase
GZI12_RS05940	COG0720	synthase
GZI12_RS05950	COG1760	l-serine dehydratase
GZI12_RS05955	COG0814	amino acid
GZI12_RS05960	COG0494	nUDIX hydrolase
GZI12_RS05990	COG3106	COG3106 Predicted ATPase
GZI12_RS05995	COG3768	UPF0283 membrane protein
GZI12_RS06005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZI12_RS06020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZI12_RS06050	COG3108	Peptidase M15
GZI12_RS06055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZI12_RS06070	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GZI12_RS06095	COG0783	Belongs to the Dps family
GZI12_RS06100	COG0415	Belongs to the DNA photolyase family
GZI12_RS06145	COG2814	Major facilitator Superfamily
GZI12_RS06150	COG3706	GGDEF domain
GZI12_RS06155	COG2205	protein histidine kinase activity
GZI12_RS06170	COG1061	Type III restriction enzyme res subunit
GZI12_RS06180	COG2814	Major facilitator Superfamily
GZI12_RS06190	COG2814	Major facilitator Superfamily
GZI12_RS06195	COG0583	DNA-binding transcription factor activity
GZI12_RS06210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GZI12_RS06210	COG0678	peroxiredoxin activity
GZI12_RS06230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZI12_RS06235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GZI12_RS06255	COG0667	Aldo Keto reductase
GZI12_RS06260	COG0702	epimerase
GZI12_RS06265	COG0534	Mate efflux family protein
GZI12_RS06270	COG1136	(ABC) transporter
GZI12_RS06290	COG2885	chlorophyll binding
GZI12_RS06310	COG0019	diaminopimelate decarboxylase activity
GZI12_RS06350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZI12_RS06355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZI12_RS06360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZI12_RS06385	COG1328	CTP reductase activity
GZI12_RS06390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GZI12_RS06415	COG0583	DNA-binding transcription factor activity
GZI12_RS06430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GZI12_RS06440	COG0584	glycerophosphoryl diester phosphodiesterase
GZI12_RS06455	COG0745	RESPONSE REGULATOR receiver
GZI12_RS06460	COG2205	protein histidine kinase activity
GZI12_RS06465	COG4774	siderophore transport
GZI12_RS06475	COG0811	peptide transport
GZI12_RS06480	COG0811	peptide transport
GZI12_RS06485	COG0848	biopolymer transport protein
GZI12_RS06490	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GZI12_RS06500	COG0765	amino acid transport
GZI12_RS06505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZI12_RS06510	COG0765	amino acid transport
GZI12_RS06515	COG1126	abc transporter atp-binding protein
GZI12_RS06545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZI12_RS06555	COG0666	response to abiotic stimulus
GZI12_RS06570	COG2208	phosphoserine phosphatase activity
GZI12_RS06575	COG1366	Belongs to the anti-sigma-factor antagonist family
GZI12_RS06580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GZI12_RS06635	COG0612	Peptidase, M16
GZI12_RS06645	COG4178	(ABC) transporter
GZI12_RS06650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GZI12_RS06660	COG0297	glycogen (starch) synthase activity
GZI12_RS06675	COG0110	maltose O-acetyltransferase activity
GZI12_RS06705	COG2204	response regulator
GZI12_RS06735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GZI12_RS06740	COG1940	carbohydrate kinase activity
GZI12_RS06750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GZI12_RS06760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GZI12_RS06765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZI12_RS06770	COG1737	Transcriptional regulator
GZI12_RS06775	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GZI12_RS06780	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GZI12_RS06805	COG3976	FMN-binding domain protein
GZI12_RS06805	COG1053	succinate dehydrogenase
GZI12_RS06845	COG0534	Mate efflux family protein
GZI12_RS06850	COG0307	riboflavin synthase, alpha
GZI12_RS06860	COG3001	Fructosamine kinase
GZI12_RS06875	COG3290	protein histidine kinase activity
GZI12_RS06875	COG0840	transmembrane signaling receptor activity
GZI12_RS06880	COG1028	Short-chain dehydrogenase reductase Sdr
GZI12_RS06895	COG1940	carbohydrate kinase activity
GZI12_RS06905	COG0303	'Molybdopterin
GZI12_RS06910	COG0746	molybdenum cofactor guanylyltransferase activity
GZI12_RS06920	COG4662	Binding-protein-dependent transport system inner membrane component
GZI12_RS06930	COG2204	response regulator
GZI12_RS06935	COG4191	Histidine kinase
GZI12_RS06955	COG0488	(ABC) transporter
GZI12_RS07000	COG0437	4 iron, 4 sulfur cluster binding
GZI12_RS07015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GZI12_RS07025	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GZI12_RS07040	COG3842	ATPase activity
GZI12_RS07065	COG0589	response to stress
GZI12_RS07070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZI12_RS07085	COG2217	Heavy metal translocating P-type atpase
GZI12_RS07095	COG2010	Cytochrome c
GZI12_RS07110	COG3278	Belongs to the heme-copper respiratory oxidase family
GZI12_RS07195	COG1067	ATP-dependent peptidase activity
GZI12_RS07200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GZI12_RS07225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GZI12_RS07225	COG0116	Belongs to the methyltransferase superfamily
GZI12_RS07245	COG2902	Dehydrogenase
GZI12_RS07270	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GZI12_RS07275	COG1956	GAF domain-containing protein
GZI12_RS07280	COG1132	(ABC) transporter
GZI12_RS07315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GZI12_RS07325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GZI12_RS07325	COG1648	precorrin-2 dehydrogenase activity
GZI12_RS07330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZI12_RS07335	COG4597	amino acid ABC transporter
GZI12_RS07340	COG0765	amino acid transport
GZI12_RS07345	COG1126	abc transporter atp-binding protein
GZI12_RS07350	COG0670	Belongs to the BI1 family
GZI12_RS07355	COG2920	part of a sulfur-relay system
GZI12_RS07360	COG1254	Belongs to the acylphosphatase family
GZI12_RS07365	COG0840	transmembrane signaling receptor activity
GZI12_RS07370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GZI12_RS07400	COG2885	chlorophyll binding
GZI12_RS07425	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GZI12_RS07430	COG0602	queuosine metabolic process
GZI12_RS07435	COG0840	transmembrane signaling receptor activity
GZI12_RS07460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZI12_RS07485	COG3063	Type IV pilus biogenesis stability protein PilW
GZI12_RS07510	COG1914	H( )-stimulated, divalent metal cation uptake system
GZI12_RS07515	COG0583	DNA-binding transcription factor activity
GZI12_RS07540	COG4139	cobalamin transport
GZI12_RS07545	COG2988	succinylglutamate desuccinylase activity
GZI12_RS07565	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GZI12_RS07575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GZI12_RS07590	COG1278	Cold shock
GZI12_RS07605	COG2925	Exonuclease
GZI12_RS07610	COG1380	Effector of murein hydrolase LrgA
GZI12_RS07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZI12_RS07635	COG4191	Histidine kinase
GZI12_RS07640	COG0471	metal ion transport
GZI12_RS07645	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GZI12_RS07650	COG0500	methyltransferase
GZI12_RS07665	COG4326	sporulation control protein
GZI12_RS07680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZI12_RS07690	COG4160	amino acid transport
GZI12_RS07735	COG0625	glutathione transferase activity
GZI12_RS07745	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GZI12_RS07755	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZI12_RS07770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZI12_RS07775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZI12_RS07795	COG3070	regulator of competence-specific genes
GZI12_RS07805	COG2431	L-lysine efflux transmembrane transporter activity
GZI12_RS07815	COG0076	glutamate decarboxylase activity
GZI12_RS07820	COG1737	Transcriptional regulator
GZI12_RS07830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GZI12_RS07840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GZI12_RS07860	COG1032	radical SAM domain protein
GZI12_RS07905	COG1115	amino acid carrier protein
GZI12_RS07910	COG1280	lysine exporter protein (LysE YggA)
GZI12_RS07920	COG0598	Magnesium transport protein CorA
GZI12_RS07925	COG0346	lactoylglutathione lyase activity
GZI12_RS07990	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS07990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS07995	COG3715	PTS system
GZI12_RS08000	COG3716	PTS system mannose fructose sorbose family IID component
GZI12_RS08010	COG2140	Oxalate decarboxylase
GZI12_RS08085	COG4735	regulation of single-species biofilm formation
GZI12_RS08190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZI12_RS08205	COG0318	PFAM AMP-dependent synthetase and ligase
GZI12_RS08210	COG0659	secondary active sulfate transmembrane transporter activity
GZI12_RS08220	COG2204	response regulator
GZI12_RS08225	COG4191	Histidine kinase
GZI12_RS08230	COG5413	integral membrane protein
GZI12_RS08245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZI12_RS08255	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZI12_RS08255	COG1902	pentaerythritol trinitrate reductase activity
GZI12_RS08290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GZI12_RS08335	COG0583	DNA-binding transcription factor activity
GZI12_RS08355	COG0625	glutathione transferase activity
GZI12_RS08370	COG3394	polysaccharide catabolic process
GZI12_RS08375	COG0110	maltose O-acetyltransferase activity
GZI12_RS08390	COG0534	Mate efflux family protein
GZI12_RS08410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZI12_RS08415	COG1621	beta-fructofuranosidase activity
GZI12_RS08425	COG1263	PTS System
GZI12_RS08425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS08430	COG0072	phenylalanine-tRNA ligase activity
GZI12_RS08430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZI12_RS08435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GZI12_RS08450	COG2133	pyrroloquinoline quinone binding
GZI12_RS08480	COG0322	excinuclease ABC activity
GZI12_RS08485	COG2197	response regulator
GZI12_RS08495	COG0417	DNA replication proofreading
GZI12_RS08500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZI12_RS08510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GZI12_RS08545	COG1607	acyl-coa hydrolase
GZI12_RS08550	COG2350	Protein conserved in bacteria
GZI12_RS08565	COG3313	Fe-S protein
GZI12_RS08575	COG4134	Bacterial extracellular solute-binding protein
GZI12_RS08580	COG4135	transport system, permease component
GZI12_RS08585	COG4136	ATPase activity
GZI12_RS08590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GZI12_RS08600	COG0564	pseudouridine synthase activity
GZI12_RS08615	COG0626	cystathionine gamma-synthase activity
GZI12_RS08620	COG2818	Glycosylase
GZI12_RS08635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZI12_RS08650	COG1842	Phage shock protein A
GZI12_RS08655	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GZI12_RS08670	COG4171	peptide transport system, permease
GZI12_RS08680	COG4172	Belongs to the ABC transporter superfamily
GZI12_RS08690	COG1227	inorganic diphosphatase activity
GZI12_RS08710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GZI12_RS08715	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GZI12_RS08720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GZI12_RS08720	COG0131	Imidazoleglycerol-phosphate dehydratase
GZI12_RS08725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GZI12_RS08730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GZI12_RS08735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GZI12_RS08740	COG1757	Na H antiporter
GZI12_RS08745	COG2916	Histone family protein nucleoid-structuring protein H-NS
GZI12_RS08750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZI12_RS08760	COG0482	sulfurtransferase activity
GZI12_RS08770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZI12_RS08790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GZI12_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
GZI12_RS08820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GZI12_RS08825	COG2226	methyltransferase
GZI12_RS08830	COG0156	8-amino-7-oxononanoate synthase activity
GZI12_RS08840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GZI12_RS08865	COG3923	Primosomal replication protein n
GZI12_RS08875	COG0708	Exodeoxyribonuclease III
GZI12_RS08880	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GZI12_RS08885	COG1960	acyl-CoA dehydrogenase activity
GZI12_RS08890	COG1309	transcriptional regulator
GZI12_RS08905	COG0463	Glycosyl transferase, family 2
GZI12_RS08910	COG0745	RESPONSE REGULATOR receiver
GZI12_RS08915	COG5002	protein histidine kinase activity
GZI12_RS08915	COG3850	Histidine kinase
GZI12_RS08940	COG0784	Response regulator, receiver
GZI12_RS08940	COG2205	protein histidine kinase activity
GZI12_RS08950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZI12_RS08965	COG3302	dmso reductase anchor subunit
GZI12_RS08970	COG0437	4 iron, 4 sulfur cluster binding
GZI12_RS08985	COG1741	Belongs to the pirin family
GZI12_RS09025	COG0346	lactoylglutathione lyase activity
GZI12_RS09060	COG0589	response to stress
GZI12_RS09070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GZI12_RS09075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZI12_RS09095	COG0814	amino acid
GZI12_RS09100	COG3681	Belongs to the UPF0597 family
GZI12_RS09105	COG1522	sequence-specific DNA binding
GZI12_RS09110	COG0402	S-adenosylhomocysteine deaminase activity
GZI12_RS09175	COG2205	protein histidine kinase activity
GZI12_RS09175	COG0784	Response regulator, receiver
GZI12_RS09200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GZI12_RS09205	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GZI12_RS09210	COG2885	chlorophyll binding
GZI12_RS09230	COG0811	peptide transport
GZI12_RS09235	COG0824	Thioesterase
GZI12_RS09245	COG4890	Cyd operon protein YbgT
GZI12_RS09250	COG1294	oxidase, subunit
GZI12_RS09255	COG1271	oxidase subunit
GZI12_RS09260	COG2255	four-way junction helicase activity
GZI12_RS09265	COG0632	four-way junction helicase activity
GZI12_RS09275	COG0243	molybdopterin cofactor binding
GZI12_RS09280	COG3005	denitrification pathway
GZI12_RS09285	COG4459	periplasmic nitrate reductase
GZI12_RS09290	COG0390	transport system, permease component
GZI12_RS09295	COG2116	formate transmembrane transporter activity
GZI12_RS09320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZI12_RS09325	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GZI12_RS09330	COG0542	response to heat
GZI12_RS09335	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GZI12_RS09340	COG1278	Cold shock
GZI12_RS09355	COG4232	protein-disulfide reductase activity
GZI12_RS09365	COG2199	diguanylate cyclase activity
GZI12_RS09375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GZI12_RS09380	COG1801	Protein of unknown function DUF72
GZI12_RS09390	COG0500	methyltransferase
GZI12_RS09395	COG4067	protein conserved in archaea
GZI12_RS09395	COG0189	ligase activity
GZI12_RS09415	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GZI12_RS09420	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GZI12_RS09425	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GZI12_RS09430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZI12_RS09435	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GZI12_RS09440	COG0745	RESPONSE REGULATOR receiver
GZI12_RS09450	COG1609	Transcriptional regulator
GZI12_RS09455	COG3070	regulator of competence-specific genes
GZI12_RS09470	COG0596	Alpha beta hydrolase
GZI12_RS09480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GZI12_RS09485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZI12_RS09510	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GZI12_RS09515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GZI12_RS09520	COG1435	thymidine kinase activity
GZI12_RS09525	COG0215	cysteine-tRNA ligase activity
GZI12_RS09530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZI12_RS09540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GZI12_RS09550	COG3139	Protein of unknown function (DUF1315)
GZI12_RS09560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZI12_RS09565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GZI12_RS09575	COG2226	methyltransferase
GZI12_RS09595	COG0668	transmembrane transport
GZI12_RS09630	COG1271	oxidase subunit
GZI12_RS09635	COG1294	oxidase, subunit
GZI12_RS09645	COG2983	Belongs to the UPF0260 family
GZI12_RS09650	COG2261	transglycosylase associated protein
GZI12_RS09665	COG0251	oxidation-reduction process
GZI12_RS09670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GZI12_RS09675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GZI12_RS09680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GZI12_RS09690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZI12_RS09695	COG2832	Protein of unknown function (DUF454)
GZI12_RS09700	COG0745	RESPONSE REGULATOR receiver
GZI12_RS09705	COG0583	DNA-binding transcription factor activity
GZI12_RS09710	COG0778	Nitroreductase
GZI12_RS09715	COG0133	tryptophan synthase activity
GZI12_RS09720	COG0243	molybdopterin cofactor binding
GZI12_RS09725	COG3005	denitrification pathway
GZI12_RS09730	COG1024	Enoyl-CoA hydratase
GZI12_RS09730	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZI12_RS09735	COG0183	Belongs to the thiolase family
GZI12_RS09740	COG1595	DNA-templated transcription, initiation
GZI12_RS09755	COG2067	long-chain fatty acid transport protein
GZI12_RS09775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZI12_RS09780	COG1138	Cytochrome C-type biogenesis protein
GZI12_RS09795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZI12_RS09800	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZI12_RS09805	COG4133	protoheme IX ABC transporter activity
GZI12_RS09815	COG0835	chemotaxis
GZI12_RS09825	COG1192	Involved in chromosome partitioning
GZI12_RS09830	COG2201	protein-glutamate methylesterase activity
GZI12_RS09835	COG0643	Histidine kinase
GZI12_RS09835	COG2198	Histidine kinase
GZI12_RS09835	COG0784	Response regulator, receiver
GZI12_RS09840	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GZI12_RS09870	COG2062	phosphohistidine phosphatase, SixA
GZI12_RS09875	COG1025	Belongs to the peptidase M16 family
GZI12_RS09880	COG3102	Protein conserved in bacteria
GZI12_RS09900	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GZI12_RS09905	COG1918	ferrous iron import across plasma membrane
GZI12_RS09915	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GZI12_RS09920	COG1121	(ABC) transporter
GZI12_RS09925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZI12_RS09930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GZI12_RS09935	COG1286	toxin biosynthetic process
GZI12_RS09940	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GZI12_RS09945	COG0285	dihydrofolate synthase activity
GZI12_RS09950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GZI12_RS09965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZI12_RS09970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZI12_RS09975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZI12_RS10005	COG2860	membrane
GZI12_RS10010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GZI12_RS10015	COG2890	protein-(glutamine-N5) methyltransferase activity
GZI12_RS10020	COG2840	Smr protein MutS2
GZI12_RS10035	COG1684	flagellar biosynthetic protein fliR
GZI12_RS10040	COG1987	bacterial-type flagellum assembly
GZI12_RS10050	COG3190	flagellar
GZI12_RS10090	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZI12_RS10100	COG1677	Flagellar hook-basal body complex protein FliE
GZI12_RS10110	COG4191	Histidine kinase
GZI12_RS10120	COG1516	flagellar protein fliS
GZI12_RS10130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GZI12_RS10145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZI12_RS10155	COG2837	iron assimilation
GZI12_RS10175	COG1393	Belongs to the ArsC family
GZI12_RS10185	COG1876	peptidase activity
GZI12_RS10200	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GZI12_RS10225	COG1611	Belongs to the LOG family
GZI12_RS10230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZI12_RS10240	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GZI12_RS10245	COG2363	Small membrane protein
GZI12_RS10255	COG0583	DNA-binding transcription factor activity
GZI12_RS10265	COG1360	Flagellar Motor Protein
GZI12_RS10270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GZI12_RS10280	COG0142	geranyltranstransferase activity
GZI12_RS10285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GZI12_RS10290	COG0564	pseudouridine synthase activity
GZI12_RS10330	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZI12_RS10335	COG0567	Dehydrogenase, E1 component
GZI12_RS10345	COG1053	succinate dehydrogenase
GZI12_RS10350	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GZI12_RS10365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GZI12_RS10375	COG0033	Phosphoglucomutase
GZI12_RS10380	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GZI12_RS10385	COG0596	Alpha beta hydrolase
GZI12_RS10395	COG0716	FMN binding
GZI12_RS10405	COG0735	belongs to the Fur family
GZI12_RS10415	COG1263	PTS System
GZI12_RS10415	COG2190	(PTS) system
GZI12_RS10415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS10420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GZI12_RS10425	COG1846	Transcriptional regulator
GZI12_RS10425	COG1940	carbohydrate kinase activity
GZI12_RS10435	COG0367	asparagine synthase
GZI12_RS10440	COG3104	oligopeptide transport
GZI12_RS10460	COG2840	Smr protein MutS2
GZI12_RS10465	COG1187	pseudouridine synthase activity
GZI12_RS10470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GZI12_RS10475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GZI12_RS10480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GZI12_RS10510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GZI12_RS10525	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GZI12_RS10555	COG0484	heat shock protein binding
GZI12_RS10560	COG0443	Heat shock 70 kDa protein
GZI12_RS10565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GZI12_RS10580	COG0583	DNA-binding transcription factor activity
GZI12_RS10585	COG0497	DNA recombination
GZI12_RS10590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZI12_RS10595	COG2914	Belongs to the UPF0125 (RnfH) family
GZI12_RS10600	COG2867	negative regulation of translational initiation
GZI12_RS10605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GZI12_RS10615	COG0582	viral genome integration into host DNA
GZI12_RS10645	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GZI12_RS10675	COG1349	DNA-binding transcription factor activity
GZI12_RS10685	COG1979	alcohol dehydrogenase
GZI12_RS10695	COG1757	Na H antiporter
GZI12_RS10700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GZI12_RS10730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZI12_RS10730	COG3153	acetyltransferase
GZI12_RS10735	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GZI12_RS10740	COG2354	Protein conserved in bacteria
GZI12_RS10745	COG2873	o-acetylhomoserine
GZI12_RS10750	COG1115	amino acid carrier protein
GZI12_RS10755	COG1584	GPR1 FUN34 yaaH family protein
GZI12_RS10760	COG0519	Catalyzes the synthesis of GMP from XMP
GZI12_RS10760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GZI12_RS10765	COG0517	IMP dehydrogenase activity
GZI12_RS10765	COG0516	GMP reductase activity
GZI12_RS10785	COG1160	GTP binding
GZI12_RS10790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZI12_RS10795	COG2976	Protein conserved in bacteria
GZI12_RS10800	COG0124	histidyl-tRNA synthetase
GZI12_RS10805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GZI12_RS10815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GZI12_RS10820	COG2166	iron-sulfur cluster assembly
GZI12_RS10825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GZI12_RS10830	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GZI12_RS10850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GZI12_RS10855	COG1074	ATP-dependent DNA helicase activity
GZI12_RS10860	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GZI12_RS10870	COG0583	DNA-binding transcription factor activity
GZI12_RS10875	COG3141	response to X-ray
GZI12_RS10880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZI12_RS10885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZI12_RS10910	COG3142	Participates in the control of copper homeostasis
GZI12_RS10935	COG0704	Plays a role in the regulation of phosphate uptake
GZI12_RS10940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZI12_RS10945	COG0581	inorganic phosphate transmembrane transporter activity
GZI12_RS10955	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GZI12_RS10960	COG0248	Ppx GppA phosphatase
GZI12_RS10970	COG5002	protein histidine kinase activity
GZI12_RS10975	COG0745	RESPONSE REGULATOR receiver
GZI12_RS10990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GZI12_RS11000	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GZI12_RS11010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZI12_RS11015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZI12_RS11020	COG1862	Preprotein translocase
GZI12_RS11025	COG0343	queuine tRNA-ribosyltransferase activity
GZI12_RS11030	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GZI12_RS11035	COG0517	IMP dehydrogenase activity
GZI12_RS11050	COG0583	DNA-binding transcription factor activity
GZI12_RS11055	COG0450	alkyl hydroperoxide reductase
GZI12_RS11070	COG2171	N-acyltransferase activity
GZI12_RS11075	COG0741	lytic transglycosylase activity
GZI12_RS11090	COG0534	Mate efflux family protein
GZI12_RS11110	COG1022	Amp-dependent synthetase and ligase
GZI12_RS11115	COG0583	DNA-binding transcription factor activity
GZI12_RS11120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZI12_RS11125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GZI12_RS11145	COG0813	purine-nucleoside phosphorylase activity
GZI12_RS11150	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GZI12_RS11165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZI12_RS11170	COG0084	hydrolase, TatD family'
GZI12_RS11175	COG3022	response to hydroperoxide
GZI12_RS11180	COG1115	amino acid carrier protein
GZI12_RS11190	COG0546	phosphoglycolate phosphatase activity
GZI12_RS11195	COG2731	YhcH YjgK YiaL family protein
GZI12_RS11215	COG0800	Aldolase
GZI12_RS11220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZI12_RS11225	COG1904	glucuronate isomerase
GZI12_RS11230	COG0246	Mannitol dehydrogenase
GZI12_RS11240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GZI12_RS11245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GZI12_RS11250	COG2186	Transcriptional regulator
GZI12_RS11265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GZI12_RS11270	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GZI12_RS11280	COG3397	chitin binding
GZI12_RS11285	COG0583	DNA-binding transcription factor activity
GZI12_RS11290	COG0730	response to heat
GZI12_RS11295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GZI12_RS11300	COG0505	Belongs to the CarA family
GZI12_RS11315	COG0653	protein targeting
GZI12_RS11325	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GZI12_RS11330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GZI12_RS11335	COG0849	cell division
GZI12_RS11340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GZI12_RS11370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GZI12_RS11380	COG0768	penicillin binding
GZI12_RS11385	COG3116	cell division
GZI12_RS11400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GZI12_RS11410	COG0792	nuclease activity
GZI12_RS11415	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GZI12_RS11420	COG2823	Periplasmic or secreted lipoprotein
GZI12_RS11425	COG2969	positive regulation of protein catabolic process
GZI12_RS11430	COG0625	glutathione transferase activity
GZI12_RS11435	COG2857	Cytochrome c1
GZI12_RS11440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GZI12_RS11445	COG0723	plastoquinol--plastocyanin reductase activity
GZI12_RS11450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GZI12_RS11455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GZI12_RS11460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GZI12_RS11465	COG3105	Protein conserved in bacteria
GZI12_RS11470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZI12_RS11480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZI12_RS11490	COG3150	esterase
GZI12_RS11500	COG3151	Protein conserved in bacteria
GZI12_RS11505	COG0494	nUDIX hydrolase
GZI12_RS11510	COG1538	Outer membrane efflux protein
GZI12_RS11515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GZI12_RS11520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GZI12_RS11525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GZI12_RS11530	COG0195	Participates in both transcription termination and antitermination
GZI12_RS11550	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZI12_RS11560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GZI12_RS11565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZI12_RS11580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZI12_RS11585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GZI12_RS11590	COG2027	D-alanyl-D-alanine carboxypeptidase
GZI12_RS11600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GZI12_RS11605	COG0739	heme binding
GZI12_RS11625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GZI12_RS11630	COG0628	permease
GZI12_RS11635	COG2813	Specifically methylates the guanine in position
GZI12_RS11645	COG0747	negative chemotaxis
GZI12_RS11655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZI12_RS11660	COG0444	Belongs to the ABC transporter superfamily
GZI12_RS11665	COG4608	Belongs to the ABC transporter superfamily
GZI12_RS11675	COG2971	BadF BadG BcrA BcrD
GZI12_RS11690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZI12_RS11695	COG3842	ATPase activity
GZI12_RS11700	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GZI12_RS11705	COG1840	ABC-type Fe3 transport system, periplasmic component
GZI12_RS11710	COG0004	ammonium transporteR
GZI12_RS11725	COG3835	regulator
GZI12_RS11730	COG1929	Belongs to the glycerate kinase type-1 family
GZI12_RS11740	COG1752	Esterase of the alpha-beta hydrolase superfamily
GZI12_RS11745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZI12_RS11750	COG1643	Atp-dependent helicase
GZI12_RS11760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GZI12_RS11765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZI12_RS11775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZI12_RS11780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GZI12_RS11790	COG0842	Transport permease protein
GZI12_RS11795	COG1131	(ABC) transporter
GZI12_RS11805	COG0288	reversible hydration of carbon dioxide
GZI12_RS11820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZI12_RS11825	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZI12_RS11830	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GZI12_RS11835	COG2186	Transcriptional regulator
GZI12_RS11840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GZI12_RS11845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GZI12_RS11850	COG4974	Belongs to the 'phage' integrase family
GZI12_RS11855	COG0716	FMN binding
GZI12_RS11865	COG0157	Belongs to the NadC ModD family
GZI12_RS11870	COG0795	lipopolysaccharide-transporting ATPase activity
GZI12_RS11875	COG0795	lipopolysaccharide-transporting ATPase activity
GZI12_RS11885	COG2927	DNA polymerase III (CHI subunit)
GZI12_RS11890	COG0525	valine-tRNA ligase activity
GZI12_RS11895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZI12_RS11900	COG0564	pseudouridine synthase activity
GZI12_RS11910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZI12_RS11915	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GZI12_RS11930	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GZI12_RS11935	COG0251	oxidation-reduction process
GZI12_RS11940	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GZI12_RS11945	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GZI12_RS11950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZI12_RS11955	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GZI12_RS11960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GZI12_RS11965	COG2967	ApaG domain
GZI12_RS11970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GZI12_RS11980	COG3610	response to peptide
GZI12_RS11985	COG2966	Psort location CytoplasmicMembrane, score
GZI12_RS11990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GZI12_RS11995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GZI12_RS12000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GZI12_RS12005	COG0142	geranyltranstransferase activity
GZI12_RS12025	COG2358	TRAP transporter, solute receptor (TAXI family
GZI12_RS12060	COG0312	modulator of DNA gyrase
GZI12_RS12065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZI12_RS12085	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GZI12_RS12175	COG3267	Type II secretory pathway component ExeA
GZI12_RS12175	COG3409	Peptidoglycan-binding domain 1 protein
GZI12_RS12200	COG2200	EAL domain
GZI12_RS12200	COG2199	diguanylate cyclase activity
GZI12_RS12205	COG0629	single-stranded DNA binding
GZI12_RS12220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZI12_RS12230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GZI12_RS12235	COG0527	aspartate kinase activity
GZI12_RS12250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GZI12_RS12255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GZI12_RS12260	COG0762	integral membrane protein
GZI12_RS12275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GZI12_RS12280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GZI12_RS12300	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GZI12_RS12305	COG0741	lytic transglycosylase activity
GZI12_RS12360	COG0204	Acyl-transferase
GZI12_RS12370	COG5007	Belongs to the BolA IbaG family
GZI12_RS12380	COG2854	intermembrane phospholipid transfer
GZI12_RS12385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GZI12_RS12390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GZI12_RS12395	COG1127	ABC transporter
GZI12_RS12405	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GZI12_RS12405	COG0517	IMP dehydrogenase activity
GZI12_RS12420	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GZI12_RS12425	COG1137	ATPase activity
GZI12_RS12435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GZI12_RS12440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS12445	COG1660	Displays ATPase and GTPase activities
GZI12_RS12450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS12455	COG2239	Acts as a magnesium transporter
GZI12_RS12460	COG1410	methionine synthase
GZI12_RS12460	COG0646	methionine synthase
GZI12_RS12560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GZI12_RS12700	COG0735	belongs to the Fur family
GZI12_RS12710	COG0529	Catalyzes the synthesis of activated sulfate
GZI12_RS12715	COG0471	metal ion transport
GZI12_RS12715	COG3273	potassium ion transport
GZI12_RS12725	COG0175	sulfate reduction
GZI12_RS12730	COG1648	precorrin-2 dehydrogenase activity
GZI12_RS12730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GZI12_RS12745	COG2153	protein acetylation
GZI12_RS12750	COG0697	spore germination
GZI12_RS12755	COG3061	Opacity-associated protein A
GZI12_RS12755	COG3266	domain, Protein
GZI12_RS12760	COG0545	Peptidyl-prolyl cis-trans isomerase
GZI12_RS12770	COG0203	ribosomal protein L17
GZI12_RS12785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GZI12_RS12790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GZI12_RS12795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GZI12_RS12800	COG0201	protein transport
GZI12_RS12805	COG0200	Binds to the 23S rRNA
GZI12_RS12810	COG1841	ribosomal large subunit assembly
GZI12_RS12825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GZI12_RS12845	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GZI12_RS12875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GZI12_RS12880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GZI12_RS12900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GZI12_RS12905	COG0051	transcription antitermination factor activity, RNA binding
GZI12_RS12910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZI12_RS12915	COG0557	exoribonuclease II activity
GZI12_RS12920	COG0402	S-adenosylhomocysteine deaminase activity
GZI12_RS12925	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GZI12_RS12930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GZI12_RS12935	COG1047	Peptidyl-prolyl cis-trans
GZI12_RS12950	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZI12_RS12955	COG0488	(ABC) transporter
GZI12_RS12965	COG0429	hydrolase of the alpha beta-hydrolase fold
GZI12_RS12990	COG1012	belongs to the aldehyde dehydrogenase family
GZI12_RS12995	COG3138	arginine N-succinyltransferase
GZI12_RS13000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZI12_RS13010	COG0180	Tryptophanyl-tRNA synthetase
GZI12_RS13015	COG0546	phosphoglycolate phosphatase activity
GZI12_RS13020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZI12_RS13025	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GZI12_RS13040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GZI12_RS13070	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GZI12_RS13080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GZI12_RS13080	COG0678	peroxiredoxin activity
GZI12_RS13090	COG3634	alkyl hydroperoxide reductase activity
GZI12_RS13100	COG0165	Argininosuccinate lyase
GZI12_RS13100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GZI12_RS13105	COG0137	argininosuccinate synthase activity
GZI12_RS13110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GZI12_RS13115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GZI12_RS13125	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GZI12_RS13130	COG1695	Transcriptional regulator
GZI12_RS13135	COG1045	serine acetyltransferase
GZI12_RS13145	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GZI12_RS13150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZI12_RS13175	COG1053	succinate dehydrogenase
GZI12_RS13180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GZI12_RS13185	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GZI12_RS13195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZI12_RS13205	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GZI12_RS13210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GZI12_RS13220	COG1609	Transcriptional regulator
GZI12_RS13225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GZI12_RS13230	COG0254	rRNA binding
GZI12_RS13235	COG0281	malic enzyme
GZI12_RS13240	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GZI12_RS13245	COG0626	cystathionine gamma-synthase activity
GZI12_RS13250	COG0527	aspartate kinase activity
GZI12_RS13250	COG0460	homoserine dehydrogenase
GZI12_RS13255	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GZI12_RS13265	COG1494	fructose-1,6-bisphosphatase
GZI12_RS13275	COG0459	protein refolding
GZI12_RS13300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GZI12_RS13320	COG1215	transferase activity, transferring glycosyl groups
GZI12_RS13370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZI12_RS13420	COG1083	cytidylyl-transferase
GZI12_RS13445	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GZI12_RS13450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GZI12_RS13455	COG1086	Polysaccharide biosynthesis protein
GZI12_RS13485	COG0463	Glycosyl transferase, family 2
GZI12_RS13495	COG1519	Transferase
GZI12_RS13500	COG3642	lipopolysaccharide core region biosynthetic process
GZI12_RS13505	COG0859	PFAM glycosyl transferase family 9
GZI12_RS13520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GZI12_RS13530	COG2194	sulfuric ester hydrolase activity
GZI12_RS13535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZI12_RS13550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GZI12_RS13555	COG1309	transcriptional regulator
GZI12_RS13560	COG1560	Kdo2-lipid A biosynthetic process
GZI12_RS13565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GZI12_RS13570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GZI12_RS13575	COG1561	YicC-like family, N-terminal region
GZI12_RS13585	COG2252	PERMEase
GZI12_RS13590	COG0194	GDP metabolic process
GZI12_RS13595	COG1758	RNA polymerase activity
GZI12_RS13600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GZI12_RS13605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZI12_RS13610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GZI12_RS13620	COG1218	3'(2'),5'-bisphosphate nucleotidase
GZI12_RS13625	COG0494	nUDIX hydrolase
GZI12_RS13635	COG1040	competence protein
GZI12_RS13640	COG0596	Alpha beta hydrolase
GZI12_RS13650	COG2183	response to ionizing radiation
GZI12_RS13655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZI12_RS13660	COG0745	RESPONSE REGULATOR receiver
GZI12_RS13675	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GZI12_RS13680	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GZI12_RS13685	COG3156	type II secretion system protein K
GZI12_RS13690	COG4795	General secretion pathway protein
GZI12_RS13695	COG2165	general secretion pathway protein
GZI12_RS13705	COG2165	general secretion pathway protein
GZI12_RS13710	COG1459	type II secretion system
GZI12_RS13715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GZI12_RS13725	COG3031	protein transport across the cell outer membrane
GZI12_RS13730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GZI12_RS13735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GZI12_RS13750	COG0456	acetyltransferase
GZI12_RS13755	COG1490	D-aminoacyl-tRNA deacylase activity
GZI12_RS13770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GZI12_RS13780	COG0174	glutamine synthetase
GZI12_RS13790	COG3852	Histidine kinase
GZI12_RS13800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZI12_RS13805	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GZI12_RS13875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GZI12_RS13895	COG0009	L-threonylcarbamoyladenylate synthase
GZI12_RS13900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GZI12_RS13905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GZI12_RS13910	COG0551	DNA topoisomerase type I activity
GZI12_RS13920	COG0758	DNA mediated transformation
GZI12_RS13925	COG1652	LysM domain
GZI12_RS13930	COG0242	peptide deformylase activity
GZI12_RS13940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GZI12_RS13940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZI12_RS13945	COG0569	domain protein
GZI12_RS13950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZI12_RS13955	COG1272	protein, Hemolysin III
GZI12_RS13960	COG4326	sporulation control protein
GZI12_RS13965	COG3084	Protein conserved in bacteria
GZI12_RS13975	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GZI12_RS13980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GZI12_RS13985	COG0204	Acyl-transferase
GZI12_RS13995	COG0606	chelatase, subunit chli
GZI12_RS14005	COG3978	acetolactate synthase activity
GZI12_RS14010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZI12_RS14015	COG0129	dihydroxy-acid dehydratase activity
GZI12_RS14025	COG0604	alcohol dehydrogenase
GZI12_RS14050	COG2119	membrane
GZI12_RS14055	COG0752	glycyl-tRNA synthetase alpha subunit
GZI12_RS14060	COG0751	glycine-tRNA ligase activity
GZI12_RS14065	COG3977	Valine--pyruvate aminotransferase
GZI12_RS14070	COG0071	Belongs to the small heat shock protein (HSP20) family
GZI12_RS14075	COG0187	DNA topoisomerase II activity
GZI12_RS14085	COG0592	DNA-directed DNA polymerase activity
GZI12_RS14100	COG0352	thiamine-phosphate diphosphorylase activity
GZI12_RS14105	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GZI12_RS14110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GZI12_RS14115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GZI12_RS14120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZI12_RS14125	COG1116	anion transmembrane transporter activity
GZI12_RS14130	COG0351	phosphomethylpyrimidine kinase
GZI12_RS14140	COG4608	Belongs to the ABC transporter superfamily
GZI12_RS14145	COG0444	Belongs to the ABC transporter superfamily
GZI12_RS14160	COG0217	transcriptional regulatory protein
GZI12_RS14170	COG1566	PFAM secretion protein HlyD family protein
GZI12_RS14180	COG3383	formate dehydrogenase (NAD+) activity
GZI12_RS14235	COG1012	belongs to the aldehyde dehydrogenase family
GZI12_RS14240	COG0814	amino acid
GZI12_RS14245	COG0753	catalase activity
GZI12_RS14270	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GZI12_RS14275	COG0372	Belongs to the citrate synthase family
GZI12_RS14285	COG2828	Protein conserved in bacteria
GZI12_RS14295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZI12_RS14310	COG0583	DNA-binding transcription factor activity
GZI12_RS14350	COG0561	phosphatase activity
GZI12_RS14360	COG0840	transmembrane signaling receptor activity
GZI12_RS14395	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZI12_RS14405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZI12_RS14405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZI12_RS14405	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GZI12_RS14410	COG1105	Belongs to the carbohydrate kinase PfkB family
GZI12_RS14415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS14415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS14420	COG1609	Transcriptional regulator
GZI12_RS14430	COG0583	DNA-binding transcription factor activity
GZI12_RS14450	COG1858	cytochrome C peroxidase
GZI12_RS14465	COG2723	6-phospho-beta-galactosidase activity
GZI12_RS14485	COG2909	trisaccharide binding
GZI12_RS14490	COG0058	SHG alpha-glucan phosphorylase activity
GZI12_RS14495	COG1640	4-alpha-glucanotransferase
GZI12_RS14500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GZI12_RS14505	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GZI12_RS14530	COG0596	Alpha beta hydrolase
GZI12_RS14535	COG0471	metal ion transport
GZI12_RS14545	COG0010	Belongs to the arginase family
GZI12_RS14550	COG1166	arginine decarboxylase activity
GZI12_RS14565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GZI12_RS14570	COG1882	Formate acetyltransferase
GZI12_RS14580	COG2169	Transcriptional regulator
GZI12_RS14595	COG0513	Belongs to the DEAD box helicase family
GZI12_RS14605	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZI12_RS14610	COG3366	ferrous iron transmembrane transporter activity
GZI12_RS14615	COG0700	Nucleoside recognition
GZI12_RS14625	COG3339	Conserved Protein
GZI12_RS14630	COG1301	dicarboxylic acid transport
GZI12_RS14645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GZI12_RS14660	COG0363	glucosamine-6-phosphate deaminase activity
GZI12_RS14670	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GZI12_RS14675	COG1162	GTPase activity
GZI12_RS14685	COG1999	signal sequence binding
GZI12_RS14695	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GZI12_RS14720	COG0259	pyridoxamine-phosphate oxidase activity
GZI12_RS14730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GZI12_RS14755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZI12_RS14765	COG1132	(ABC) transporter
GZI12_RS14785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZI12_RS14800	COG1122	ATPase activity
GZI12_RS14805	COG4720	Psort location CytoplasmicMembrane, score
GZI12_RS14810	COG1566	PFAM secretion protein HlyD family protein
GZI12_RS14820	COG3706	GGDEF domain
GZI12_RS14840	COG3272	Protein of unknown function (DUF1722)
GZI12_RS14845	COG0789	Transcriptional regulator
GZI12_RS14850	COG0415	Belongs to the DNA photolyase family
GZI12_RS14855	COG1388	LysM domain
GZI12_RS14855	COG1376	ErfK ybiS ycfS ynhG family protein
GZI12_RS14865	COG0842	Transport permease protein
GZI12_RS14870	COG1131	(ABC) transporter
GZI12_RS14880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZI12_RS14885	COG2084	Dehydrogenase
GZI12_RS14895	COG0513	Belongs to the DEAD box helicase family
GZI12_RS14900	COG4948	Mandelate Racemase Muconate Lactonizing
GZI12_RS14910	COG1053	succinate dehydrogenase
GZI12_RS14910	COG3976	FMN-binding domain protein
GZI12_RS14915	COG1802	Transcriptional regulator
GZI12_RS14960	COG1869	D-ribose catabolic process
GZI12_RS14965	COG0738	Major facilitator superfamily
GZI12_RS14975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZI12_RS14980	COG1609	Transcriptional regulator
GZI12_RS14990	COG0513	Belongs to the DEAD box helicase family
GZI12_RS14995	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GZI12_RS15025	COG0402	S-adenosylhomocysteine deaminase activity
GZI12_RS15035	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GZI12_RS15105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GZI12_RS15125	COG0667	Aldo Keto reductase
GZI12_RS15140	COG2188	Transcriptional regulator
GZI12_RS15145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS15145	COG1263	PTS System
GZI12_RS15150	COG2226	methyltransferase
GZI12_RS15195	COG1914	H( )-stimulated, divalent metal cation uptake system
GZI12_RS15200	COG4667	esterase of the alpha-beta hydrolase superfamily
GZI12_RS15250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GZI12_RS15250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GZI12_RS15255	COG0516	GMP reductase activity
GZI12_RS15265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZI12_RS15270	COG1979	alcohol dehydrogenase
GZI12_RS15275	COG0697	spore germination
GZI12_RS15280	COG2176	DNA-directed DNA polymerase activity
GZI12_RS15290	COG2186	Transcriptional regulator
GZI12_RS15295	COG1028	Short-chain dehydrogenase reductase Sdr
GZI12_RS15330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZI12_RS15355	COG1917	Cupin 2, conserved barrel domain protein
GZI12_RS15360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZI12_RS15365	COG0800	Aldolase
GZI12_RS15370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZI12_RS15395	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GZI12_RS15420	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GZI12_RS15425	COG0583	DNA-binding transcription factor activity
GZI12_RS15435	COG1609	Transcriptional regulator
GZI12_RS15440	COG1486	melibiose metabolic process
GZI12_RS15445	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZI12_RS15450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZI12_RS15470	COG2186	Transcriptional regulator
GZI12_RS15480	COG0800	Aldolase
GZI12_RS15500	COG4948	Mandelate Racemase Muconate Lactonizing
GZI12_RS15505	COG0129	dihydroxy-acid dehydratase activity
GZI12_RS15520	COG1979	alcohol dehydrogenase
GZI12_RS15555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZI12_RS15570	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GZI12_RS15575	COG0179	Fumarylacetoacetate (FAA) hydrolase
GZI12_RS15605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZI12_RS15615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZI12_RS15620	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GZI12_RS15625	COG1845	cytochrome c oxidase, subunit III
GZI12_RS15635	COG3346	SURF1 family
GZI12_RS15645	COG1612	heme a metabolic process
GZI12_RS15650	COG0109	protoheme IX farnesyltransferase activity
GZI12_RS15665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GZI12_RS15670	COG4989	oxidoreductase activity
GZI12_RS15685	COG1309	transcriptional regulator
GZI12_RS15755	COG0583	DNA-binding transcription factor activity
GZI12_RS15765	COG1119	ATPase activity
GZI12_RS15770	COG1757	Na H antiporter
GZI12_RS15795	COG1716	ATPase activity
GZI12_RS15795	COG5001	Diguanylate cyclase
GZI12_RS15800	COG0402	S-adenosylhomocysteine deaminase activity
GZI12_RS15810	COG0243	molybdopterin cofactor binding
GZI12_RS15815	COG0437	4 iron, 4 sulfur cluster binding
GZI12_RS15820	COG3302	dmso reductase anchor subunit
GZI12_RS15825	COG3381	protein complex oligomerization
GZI12_RS15835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GZI12_RS15840	COG0298	carbon dioxide binding
GZI12_RS15855	COG0375	protein maturation
GZI12_RS15860	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GZI12_RS15865	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GZI12_RS15870	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
GZI12_RS15875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GZI12_RS15885	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GZI12_RS15895	COG0601	transmembrane transport
GZI12_RS15900	COG4171	peptide transport system, permease
GZI12_RS15905	COG0444	Belongs to the ABC transporter superfamily
GZI12_RS15910	COG1124	(ABC) transporter
GZI12_RS15925	COG1278	Cold shock
GZI12_RS15990	COG1794	racemase activity, acting on amino acids and derivatives
GZI12_RS16015	COG0531	amino acid
GZI12_RS16030	COG0673	inositol 2-dehydrogenase activity
GZI12_RS16035	COG1765	OsmC-like protein
GZI12_RS16045	COG3706	GGDEF domain
GZI12_RS16060	COG2304	oxidoreductase activity
GZI12_RS16075	COG0714	Associated with various cellular activities
GZI12_RS16085	COG0579	oxidoreductase
GZI12_RS16130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZI12_RS16145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZI12_RS16145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZI12_RS16145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS16150	COG2207	Transcriptional regulator
GZI12_RS16160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZI12_RS16165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZI12_RS16175	COG0573	inorganic phosphate transmembrane transporter activity
GZI12_RS16180	COG0581	inorganic phosphate transmembrane transporter activity
GZI12_RS16205	COG0384	phenazine biosynthesis protein PhzF
GZI12_RS16215	COG0156	8-amino-7-oxononanoate synthase activity
GZI12_RS16295	COG0456	acetyltransferase
GZI12_RS16325	COG0653	protein targeting
GZI12_RS16350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZI12_RS16355	COG0583	DNA-binding transcription factor activity
GZI12_RS16360	COG1840	ABC-type Fe3 transport system, periplasmic component
GZI12_RS16365	COG3842	ATPase activity
GZI12_RS16395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GZI12_RS16400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GZI12_RS16405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GZI12_RS16420	COG1263	PTS System
GZI12_RS16420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS16435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GZI12_RS16440	COG0662	Cupin 2, conserved barrel domain protein
GZI12_RS16445	COG0527	aspartate kinase activity
GZI12_RS16450	COG1288	antiporter activity
GZI12_RS16460	COG0330	HflC and HflK could
GZI12_RS16515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GZI12_RS16550	COG0302	gtp cyclohydrolase
GZI12_RS16555	COG0513	Belongs to the DEAD box helicase family
GZI12_RS16560	COG0277	FAD linked oxidase domain protein
GZI12_RS16590	COG2814	Major facilitator Superfamily
GZI12_RS16600	COG1846	Transcriptional regulator
GZI12_RS16605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZI12_RS16615	COG0814	amino acid
GZI12_RS16620	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GZI12_RS16625	COG0513	Belongs to the DEAD box helicase family
GZI12_RS16640	COG0183	Belongs to the thiolase family
GZI12_RS16655	COG3040	lipid binding
GZI12_RS16675	COG0640	Transcriptional regulator
GZI12_RS16695	COG1328	CTP reductase activity
GZI12_RS16700	COG0602	queuosine metabolic process
GZI12_RS16715	COG4067	protein conserved in archaea
GZI12_RS16715	COG0189	ligase activity
GZI12_RS16720	COG0545	Peptidyl-prolyl cis-trans isomerase
GZI12_RS16730	COG2885	chlorophyll binding
GZI12_RS16730	COG3047	cAMP biosynthetic process
GZI12_RS16760	COG2827	Endonuclease containing a URI domain
GZI12_RS16785	COG1289	transmembrane transporter activity
GZI12_RS16790	COG0210	DNA helicase
GZI12_RS16805	COG0784	Response regulator, receiver
GZI12_RS16805	COG2198	Histidine kinase
GZI12_RS16805	COG2205	protein histidine kinase activity
GZI12_RS16815	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GZI12_RS16835	COG1492	cobalamin metabolic process
GZI12_RS16840	COG0725	ABC transporter, periplasmic molybdate-binding protein
GZI12_RS16845	COG4149	molybdate abc transporter
GZI12_RS16865	COG3706	GGDEF domain
GZI12_RS16880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GZI12_RS16885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GZI12_RS16910	COG3140	Belongs to the UPF0181 family
GZI12_RS16925	COG0023	Translation Initiation Factor
GZI12_RS16940	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZI12_RS16950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZI12_RS16950	COG1042	CoA-binding domain protein
GZI12_RS16950	COG0045	succinate-CoA ligase (ADP-forming) activity
GZI12_RS16955	COG0583	DNA-binding transcription factor activity
GZI12_RS16965	COG4533	DNA binding
GZI12_RS16975	COG2050	protein possibly involved in aromatic compounds catabolism
GZI12_RS16990	COG2824	Alkylphosphonate utilization operon protein PhnA
GZI12_RS17005	COG0861	Integral membrane protein TerC family
GZI12_RS17010	COG0737	Belongs to the 5'-nucleotidase family
GZI12_RS17020	COG0583	DNA-binding transcription factor activity
GZI12_RS17025	COG2116	formate transmembrane transporter activity
GZI12_RS17050	COG3069	C4-dicarboxylate transmembrane transporter activity
GZI12_RS17060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GZI12_RS17070	COG1984	allophanate hydrolase subunit 2
GZI12_RS17080	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GZI12_RS17085	COG4181	ATPase activity
GZI12_RS17095	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GZI12_RS17100	COG5001	Diguanylate cyclase
GZI12_RS17100	COG3300	MHYT domain
GZI12_RS17125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZI12_RS17140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZI12_RS17180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZI12_RS17185	COG1028	Short-chain dehydrogenase reductase Sdr
GZI12_RS17195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZI12_RS17225	COG1215	transferase activity, transferring glycosyl groups
GZI12_RS17250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZI12_RS17280	COG0494	nUDIX hydrolase
GZI12_RS17310	COG0463	Glycosyl transferase, family 2
GZI12_RS17325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GZI12_RS17415	COG1538	Outer membrane efflux protein
GZI12_RS17435	COG0701	Predicted permease
GZI12_RS17460	COG2304	oxidoreductase activity
GZI12_RS17475	COG0714	Associated with various cellular activities
GZI12_RS17480	COG3063	Type IV pilus biogenesis stability protein PilW
GZI12_RS17485	COG3119	arylsulfatase activity
GZI12_RS17490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GZI12_RS17510	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GZI12_RS17515	COG2264	protein methyltransferase activity
GZI12_RS17540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GZI12_RS17545	COG0363	glucosamine-6-phosphate deaminase activity
GZI12_RS17550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GZI12_RS17560	COG2095	MarC family integral membrane protein
GZI12_RS17565	COG3300	MHYT domain
GZI12_RS17565	COG5001	Diguanylate cyclase
GZI12_RS17575	COG0513	Belongs to the DEAD box helicase family
GZI12_RS17590	COG0318	PFAM AMP-dependent synthetase and ligase
GZI12_RS17600	COG0739	heme binding
GZI12_RS17605	COG0523	cobalamin synthesis protein
GZI12_RS17610	COG0583	DNA-binding transcription factor activity
GZI12_RS17615	COG1556	Lactate utilization protein
GZI12_RS17620	COG1139	Iron-sulfur cluster binding protein
GZI12_RS17625	COG0247	lactate metabolic process
GZI12_RS17630	COG1620	l-lactate permease
GZI12_RS17635	COG4628	conserved protein (DUF2132)
GZI12_RS17645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GZI12_RS17655	COG4604	ABC transporter, ATP-binding protein
GZI12_RS17660	COG4605	iron ion homeostasis
GZI12_RS17665	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZI12_RS17670	COG4607	ABC-type enterochelin transport system periplasmic component
GZI12_RS17680	COG4172	Belongs to the ABC transporter superfamily
GZI12_RS17685	COG4239	(ABC) transporter, permease
GZI12_RS17690	COG4174	ABC transporter (Permease)
GZI12_RS17755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZI12_RS17780	COG1280	lysine exporter protein (LysE YggA)
GZI12_RS17835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZI12_RS17875	COG0523	cobalamin synthesis protein
GZI12_RS17895	COG0419	ATPase involved in DNA repair
GZI12_RS17900	COG0420	3'-5' exonuclease activity
GZI12_RS17905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZI12_RS17930	COG3008	intermembrane lipid transfer
GZI12_RS17930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GZI12_RS17935	COG2995	paraquat-inducible protein a
GZI12_RS17955	COG2502	aspartate--ammonia ligase
GZI12_RS17990	COG0697	spore germination
GZI12_RS17995	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GZI12_RS18010	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GZI12_RS18020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GZI12_RS18030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GZI12_RS18065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZI12_RS18070	COG0784	Response regulator, receiver
GZI12_RS18070	COG0835	chemotaxis
GZI12_RS18075	COG3706	GGDEF domain
GZI12_RS18090	COG1760	l-serine dehydratase
GZI12_RS18095	COG3104	oligopeptide transport
GZI12_RS18120	COG1011	Hydrolase
GZI12_RS18130	COG2154	pterin-4-alpha-carbinolamine dehydratase
GZI12_RS18135	COG3186	Phenylalanine-4-hydroxylase
GZI12_RS18165	COG3119	arylsulfatase activity
GZI12_RS18170	COG0641	radical SAM
GZI12_RS18175	COG0513	Belongs to the DEAD box helicase family
GZI12_RS18205	COG3530	Putative quorum-sensing-regulated virulence factor
GZI12_RS18220	COG1686	Belongs to the peptidase S11 family
GZI12_RS18230	COG1278	Cold shock
GZI12_RS18250	COG0745	RESPONSE REGULATOR receiver
GZI12_RS18255	COG0471	metal ion transport
GZI12_RS18260	COG1017	nitric oxide dioxygenase activity
GZI12_RS18260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GZI12_RS18265	COG3604	Transcriptional regulator
GZI12_RS18275	COG0546	phosphoglycolate phosphatase activity
GZI12_RS18280	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZI12_RS18295	COG0697	spore germination
GZI12_RS18325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GZI12_RS18340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GZI12_RS18350	COG0509	glycine decarboxylation via glycine cleavage system
GZI12_RS18390	COG3706	GGDEF domain
GZI12_RS18425	COG2814	Major facilitator Superfamily
GZI12_RS18430	COG0772	Belongs to the SEDS family
GZI12_RS18440	COG0346	lactoylglutathione lyase activity
GZI12_RS18445	COG1902	pentaerythritol trinitrate reductase activity
GZI12_RS18450	COG1881	PFAM PEBP family protein
GZI12_RS18470	COG2233	PERMEase
GZI12_RS18475	COG0402	S-adenosylhomocysteine deaminase activity
GZI12_RS18565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GZI12_RS18575	COG0668	transmembrane transport
GZI12_RS18590	COG0384	phenazine biosynthesis protein PhzF
GZI12_RS18600	COG4628	conserved protein (DUF2132)
GZI12_RS18610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GZI12_RS18620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZI12_RS18625	COG0800	Aldolase
GZI12_RS18635	COG1028	Short-chain dehydrogenase reductase Sdr
GZI12_RS18640	COG1414	Transcriptional regulator
GZI12_RS18665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS18665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS18670	COG3716	PTS system mannose fructose sorbose family IID component
GZI12_RS18675	COG3715	PTS system
GZI12_RS18695	COG5492	domain, Protein
GZI12_RS18715	COG1595	DNA-templated transcription, initiation
GZI12_RS18740	COG0583	DNA-binding transcription factor activity
GZI12_RS18745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GZI12_RS18760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZI12_RS18770	COG1349	DNA-binding transcription factor activity
GZI12_RS18780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZI12_RS18785	COG0738	Major facilitator superfamily
GZI12_RS18820	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GZI12_RS18830	COG2207	Transcriptional regulator
GZI12_RS18830	COG1917	Cupin 2, conserved barrel domain protein
GZI12_RS18840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GZI12_RS18845	COG0583	DNA-binding transcription factor activity
GZI12_RS18865	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GZI12_RS18870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS18870	COG1263	PTS System
GZI12_RS18880	COG0564	pseudouridine synthase activity
GZI12_RS18885	COG2909	trisaccharide binding
GZI12_RS18890	COG0058	SHG alpha-glucan phosphorylase activity
GZI12_RS18895	COG1640	4-alpha-glucanotransferase
GZI12_RS18900	COG0366	Alpha amylase catalytic
GZI12_RS18905	COG0840	transmembrane signaling receptor activity
GZI12_RS18925	COG1175	transmembrane transport
GZI12_RS18930	COG3833	ABC-type maltose transport systems, permease component
GZI12_RS18935	COG4580	involved in the transport of maltose and maltodextrins
GZI12_RS18945	COG0589	response to stress
GZI12_RS18970	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZI12_RS18975	COG0583	DNA-binding transcription factor activity
GZI12_RS18980	COG0529	Catalyzes the synthesis of activated sulfate
GZI12_RS18990	COG0789	Transcriptional regulator
GZI12_RS19045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZI12_RS19050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZI12_RS19065	COG0574	Belongs to the PEP-utilizing enzyme family
GZI12_RS19065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZI12_RS19085	COG0395	ABC-type sugar transport system, permease component
GZI12_RS19100	COG1609	Transcriptional regulator
GZI12_RS19105	COG3459	Glycosyltransferase 36 associated
GZI12_RS19135	COG0583	DNA-binding transcription factor activity
GZI12_RS19165	COG0672	)-iron permease
GZI12_RS19175	COG2837	iron assimilation
GZI12_RS19180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GZI12_RS19190	COG2807	transmembrane transport
GZI12_RS19195	COG2207	Transcriptional regulator
GZI12_RS19250	COG0737	Belongs to the 5'-nucleotidase family
GZI12_RS19280	COG1280	lysine exporter protein (LysE YggA)
GZI12_RS19305	COG0786	glutamate:sodium symporter activity
GZI12_RS19320	COG1263	PTS System
GZI12_RS19320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS19335	COG1024	Enoyl-CoA hydratase
GZI12_RS19340	COG0583	DNA-binding transcription factor activity
GZI12_RS19350	COG1301	dicarboxylic acid transport
GZI12_RS19355	COG1252	NADH dehydrogenase
GZI12_RS19375	COG1028	Short-chain dehydrogenase reductase Sdr
GZI12_RS19400	COG1263	PTS System
GZI12_RS19400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS19405	COG0583	DNA-binding transcription factor activity
GZI12_RS19410	COG0583	DNA-binding transcription factor activity
GZI12_RS19420	COG1982	Orn Lys Arg decarboxylase major
GZI12_RS19425	COG0531	amino acid
GZI12_RS19445	COG4176	ABC-type proline glycine betaine transport system permease component
GZI12_RS19450	COG3448	diguanylate cyclase activity
GZI12_RS19450	COG4175	Glycine betaine
GZI12_RS19485	COG1253	flavin adenine dinucleotide binding
GZI12_RS19510	COG1349	DNA-binding transcription factor activity
GZI12_RS19530	COG0667	Aldo Keto reductase
GZI12_RS19535	COG0738	Major facilitator superfamily
GZI12_RS19560	COG1115	amino acid carrier protein
GZI12_RS19565	COG0415	Belongs to the DNA photolyase family
GZI12_RS19580	COG0531	amino acid
GZI12_RS19605	COG1482	cell wall glycoprotein biosynthetic process
GZI12_RS19610	COG0383	alpha-mannosidase activity
GZI12_RS19615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZI12_RS19615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZI12_RS19615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZI12_RS19620	COG2188	Transcriptional regulator
GZI12_RS19645	COG2190	(PTS) system
GZI12_RS19645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZI12_RS19645	COG1263	PTS System
GZI12_RS19650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GZI12_RS19675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GZI12_RS19680	COG1882	Formate acetyltransferase
GZI12_RS19715	COG0745	RESPONSE REGULATOR receiver
GZI12_RS19730	COG0745	RESPONSE REGULATOR receiver
GZI12_RS19755	COG3153	acetyltransferase
GZI12_RS19760	COG3811	Belongs to the UPF0386 family
GZI12_RS19765	COG0583	DNA-binding transcription factor activity
GZI12_RS19810	COG2814	Major facilitator Superfamily
GZI12_RS19815	COG2207	Transcriptional regulator
GZI12_RS19830	COG1501	Belongs to the glycosyl hydrolase 31 family
GZI12_RS19835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GZI12_RS19845	COG0583	DNA-binding transcription factor activity
GZI12_RS19850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZI12_RS19860	COG1342	Belongs to the UPF0251 family
GZI12_RS19875	COG2176	DNA-directed DNA polymerase activity
GZI12_RS19890	COG0583	DNA-binding transcription factor activity
GZI12_RS19925	COG1511	domain protein
GZI12_RS19925	COG3264	Mechanosensitive ion channel
GZI12_RS19930	COG0604	alcohol dehydrogenase
GZI12_RS19945	COG1444	tRNA N-acetyltransferase activity
GZI12_RS20075	COG0424	maF-like protein
GZI12_RS20080	COG0424	maF-like protein