locus-tag	class	description
VS_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VS_RS00015	COG0706	membrane insertase activity
VS_RS00020	COG0594	ribonuclease P activity
VS_RS00025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VS_RS00030	COG1126	abc transporter atp-binding protein
VS_RS00045	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VS_RS00050	COG0592	DNA-directed DNA polymerase activity
VS_RS00055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VS_RS00060	COG0187	DNA topoisomerase II activity
VS_RS00070	COG3977	Valine--pyruvate aminotransferase
VS_RS00090	COG4964	Belongs to the GSP D family
VS_RS00155	COG0751	glycine-tRNA ligase activity
VS_RS00160	COG0752	glycyl-tRNA synthetase alpha subunit
VS_RS00165	COG2119	membrane
VS_RS00175	COG0425	Belongs to the sulfur carrier protein TusA family
VS_RS00190	COG0604	alcohol dehydrogenase
VS_RS00195	COG0183	Belongs to the thiolase family
VS_RS00200	COG1250	3-hydroxyacyl-CoA dehydrogenase
VS_RS00200	COG1024	Enoyl-CoA hydratase
VS_RS00205	COG1739	Uncharacterized protein family UPF0029
VS_RS00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VS_RS00260	COG0583	DNA-binding transcription factor activity
VS_RS00265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VS_RS00270	COG2960	long-chain fatty acid transporting porin activity
VS_RS00275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_RS00280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_RS00285	COG1309	transcriptional regulator
VS_RS00335	COG0601	transmembrane transport
VS_RS00340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_RS00365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VS_RS00370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VS_RS00380	COG1522	sequence-specific DNA binding
VS_RS00385	COG5002	protein histidine kinase activity
VS_RS00385	COG5001	Diguanylate cyclase
VS_RS00390	COG0742	ribosomal rna small subunit methyltransferase
VS_RS00405	COG0589	response to stress
VS_RS00410	COG1528	Iron-storage protein
VS_RS00420	COG2081	HI0933 family
VS_RS00435	COG1322	Protein conserved in bacteria
VS_RS00440	COG2226	methyltransferase
VS_RS00445	COG3165	ubiquinone biosynthetic process from chorismate
VS_RS00450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VS_RS00455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VS_RS00460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VS_RS00465	COG0805	protein transport
VS_RS00470	COG0084	hydrolase, TatD family'
VS_RS00485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VS_RS00485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VS_RS00495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VS_RS00510	COG3078	GTPase activator activity
VS_RS00535	COG3852	Histidine kinase
VS_RS00545	COG0174	glutamine synthetase
VS_RS00550	COG1217	gtp-binding protein TYPA
VS_RS00565	COG1295	ribonuclease BN
VS_RS00570	COG1490	D-aminoacyl-tRNA deacylase activity
VS_RS00575	COG0456	acetyltransferase
VS_RS00585	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VS_RS00595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VS_RS00600	COG3031	protein transport across the cell outer membrane
VS_RS00610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VS_RS00615	COG1459	type II secretion system
VS_RS00620	COG2165	general secretion pathway protein
VS_RS00625	COG2165	general secretion pathway protein
VS_RS00630	COG2165	general secretion pathway protein
VS_RS00635	COG4795	General secretion pathway protein
VS_RS00640	COG3156	type II secretion system protein K
VS_RS00645	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VS_RS00650	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VS_RS00660	COG1218	3'(2'),5'-bisphosphate nucleotidase
VS_RS00665	COG0494	nUDIX hydrolase
VS_RS00670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VS_RS00670	COG0316	Belongs to the HesB IscA family
VS_RS00675	COG1040	competence protein
VS_RS00680	COG0596	Alpha beta hydrolase
VS_RS00690	COG2183	response to ionizing radiation
VS_RS00695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VS_RS00710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VS_RS00715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VS_RS00720	COG1758	RNA polymerase activity
VS_RS00725	COG0194	GDP metabolic process
VS_RS00730	COG2252	PERMEase
VS_RS00745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_RS00745	COG1263	PTS System
VS_RS00755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VS_RS00760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VS_RS00770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_RS00775	COG1454	alcohol dehydrogenase
VS_RS00785	COG0561	phosphatase activity
VS_RS00795	COG1278	Cold shock
VS_RS00800	COG1561	YicC-like family, N-terminal region
VS_RS00805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VS_RS00810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VS_RS00815	COG1560	Kdo2-lipid A biosynthetic process
VS_RS00820	COG1309	transcriptional regulator
VS_RS00825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VS_RS00830	COG2003	Belongs to the UPF0758 family
VS_RS00835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VS_RS00840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VS_RS00850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VS_RS00860	COG0859	PFAM glycosyl transferase family 9
VS_RS00865	COG1519	Transferase
VS_RS00880	COG3642	lipopolysaccharide core region biosynthetic process
VS_RS00890	COG0859	PFAM glycosyl transferase family 9
VS_RS00895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VS_RS00905	COG0438	transferase activity, transferring glycosyl groups
VS_RS00905	COG4641	Protein conserved in bacteria
VS_RS00915	COG1560	Kdo2-lipid A biosynthetic process
VS_RS00930	COG4942	peptidase
VS_RS00935	COG1045	serine acetyltransferase
VS_RS00945	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VS_RS00950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VS_RS00970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_RS00975	COG1596	polysaccharide export
VS_RS00985	COG0489	protein tyrosine kinase activity
VS_RS00985	COG3206	protein involved in exopolysaccharide biosynthesis
VS_RS00990	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VS_RS00995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VS_RS01005	COG0517	IMP dehydrogenase activity
VS_RS01005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VS_RS01030	COG0110	maltose O-acetyltransferase activity
VS_RS01035	COG0438	transferase activity, transferring glycosyl groups
VS_RS01070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VS_RS01080	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VS_RS01085	COG0534	Mate efflux family protein
VS_RS01090	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
VS_RS01095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VS_RS01110	COG2203	Gaf domain
VS_RS01110	COG2199	diguanylate cyclase activity
VS_RS01115	COG1285	pathogenesis
VS_RS01120	COG1509	lysine 2,3-aminomutase activity
VS_RS01125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VS_RS01135	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VS_RS01140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VS_RS01145	COG1053	succinate dehydrogenase
VS_RS01150	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VS_RS01160	COG0840	transmembrane signaling receptor activity
VS_RS01165	COG0471	metal ion transport
VS_RS01165	COG0490	domain, Protein
VS_RS01180	COG1162	GTPase activity
VS_RS01225	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VS_RS01230	COG0802	atpase or kinase
VS_RS01235	COG0860	N-Acetylmuramoyl-L-alanine amidase
VS_RS01240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VS_RS01245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VS_RS01250	COG1923	regulation of RNA biosynthetic process
VS_RS01255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VS_RS01260	COG0330	HflC and HflK could
VS_RS01265	COG0330	HflC and HflK could
VS_RS01270	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VS_RS01275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VS_RS01280	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VS_RS01285	COG0402	S-adenosylhomocysteine deaminase activity
VS_RS01290	COG0557	exoribonuclease II activity
VS_RS01295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VS_RS01300	COG0360	Binds together with S18 to 16S ribosomal RNA
VS_RS01310	COG0359	binds to the 23S rRNA
VS_RS01325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VS_RS01335	COG0432	Pfam Uncharacterised protein family UPF0047
VS_RS01340	COG0166	Belongs to the GPI family
VS_RS01350	COG0735	belongs to the Fur family
VS_RS01390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VS_RS01395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VS_RS01400	COG0175	sulfate reduction
VS_RS01445	COG0527	aspartate kinase activity
VS_RS01450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VS_RS01460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VS_RS01470	COG2197	response regulator
VS_RS01475	COG0629	single-stranded DNA binding
VS_RS01480	COG2199	diguanylate cyclase activity
VS_RS01480	COG2200	EAL domain
VS_RS01505	COG3409	Peptidoglycan-binding domain 1 protein
VS_RS01505	COG3267	Type II secretory pathway component ExeA
VS_RS01515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VS_RS01520	COG1459	type II secretion system
VS_RS01530	COG2165	general secretion pathway protein
VS_RS01535	COG2165	general secretion pathway protein
VS_RS01565	COG1077	Cell shape determining protein MreB Mrl
VS_RS01570	COG1792	Involved in formation and maintenance of cell shape
VS_RS01575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VS_RS01580	COG0424	maF-like protein
VS_RS01590	COG3164	Protein of unknown function
VS_RS01595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VS_RS01600	COG0312	modulator of DNA gyrase
VS_RS01605	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VS_RS01610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VS_RS01620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VS_RS01625	COG0589	response to stress
VS_RS01640	COG1438	arginine binding
VS_RS01645	COG0039	L-malate dehydrogenase activity
VS_RS01655	COG0142	geranyltranstransferase activity
VS_RS01660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VS_RS01665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VS_RS01670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VS_RS01680	COG3610	response to peptide
VS_RS01695	COG2967	ApaG domain
VS_RS01700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VS_RS01705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VS_RS01710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VS_RS01715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VS_RS01720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VS_RS01735	COG0066	3-isopropylmalate dehydratase activity
VS_RS01745	COG0473	3-isopropylmalate dehydrogenase activity
VS_RS01750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VS_RS01785	COG1022	Amp-dependent synthetase and ligase
VS_RS01790	COG0028	Belongs to the TPP enzyme family
VS_RS01815	COG0469	pyruvate kinase activity
VS_RS01820	COG1349	DNA-binding transcription factor activity
VS_RS01825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VS_RS01830	COG2873	o-acetylhomoserine
VS_RS01850	COG1610	YqeY-like protein
VS_RS01855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VS_RS01860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VS_RS01865	COG0596	Alpha beta hydrolase
VS_RS01870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VS_RS01875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VS_RS01880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_RS01885	COG1968	undecaprenyl-diphosphatase activity
VS_RS01890	COG0617	tRNA 3'-terminal CCA addition
VS_RS01895	COG3267	Type II secretory pathway component ExeA
VS_RS01895	COG3409	Peptidoglycan-binding domain 1 protein
VS_RS01905	COG4991	sh3 domain protein
VS_RS01910	COG0306	phosphate transporter
VS_RS01915	COG1392	Phosphate transport regulator
VS_RS01920	COG3025	triphosphatase activity
VS_RS01925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VS_RS01935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VS_RS01940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VS_RS01940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VS_RS01945	COG1538	Outer membrane efflux protein
VS_RS01950	COG0494	nUDIX hydrolase
VS_RS01955	COG3151	Protein conserved in bacteria
VS_RS01965	COG3150	esterase
VS_RS01980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VS_RS01990	COG3105	Protein conserved in bacteria
VS_RS01995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VS_RS02000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VS_RS02005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VS_RS02010	COG0723	plastoquinol--plastocyanin reductase activity
VS_RS02015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VS_RS02020	COG2857	Cytochrome c1
VS_RS02025	COG0625	glutathione transferase activity
VS_RS02030	COG2969	positive regulation of protein catabolic process
VS_RS02035	COG2823	Periplasmic or secreted lipoprotein
VS_RS02040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VS_RS02055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VS_RS02060	COG0275	rRNA processing
VS_RS02065	COG3116	cell division
VS_RS02070	COG0768	penicillin binding
VS_RS02075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VS_RS02080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VS_RS02085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VS_RS02090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VS_RS02095	COG0772	Belongs to the SEDS family
VS_RS02100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VS_RS02105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VS_RS02120	COG0849	cell division
VS_RS02125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VS_RS02130	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VS_RS02135	COG0653	protein targeting
VS_RS02150	COG0494	nUDIX hydrolase
VS_RS02155	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VS_RS02160	COG0505	Belongs to the CarA family
VS_RS02165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VS_RS02170	COG0730	response to heat
VS_RS02175	COG0583	DNA-binding transcription factor activity
VS_RS02180	COG2860	membrane
VS_RS02185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VS_RS02195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VS_RS02205	COG0493	'glutamate synthase
VS_RS02220	COG0067	glutamate synthase
VS_RS02220	COG0069	glutamate synthase activity
VS_RS02220	COG0070	glutamate synthase
VS_RS02225	COG1242	4 iron, 4 sulfur cluster binding
VS_RS02230	COG2203	Gaf domain
VS_RS02230	COG3706	GGDEF domain
VS_RS02230	COG4251	negative regulation of phosphorylation
VS_RS02230	COG5001	Diguanylate cyclase
VS_RS02235	COG0784	Response regulator, receiver
VS_RS02235	COG2198	Histidine kinase
VS_RS02235	COG5002	protein histidine kinase activity
VS_RS02245	COG0745	RESPONSE REGULATOR receiver
VS_RS02250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VS_RS02265	COG0083	homoserine kinase activity
VS_RS02270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VS_RS02300	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VS_RS02305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VS_RS02310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VS_RS02325	COG1115	amino acid carrier protein
VS_RS02330	COG3022	response to hydroperoxide
VS_RS02335	COG0513	Belongs to the DEAD box helicase family
VS_RS02340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VS_RS02360	COG4974	Belongs to the 'phage' integrase family
VS_RS02365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VS_RS02370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VS_RS02375	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VS_RS02405	COG0494	nUDIX hydrolase
VS_RS02415	COG0730	response to heat
VS_RS02420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VS_RS02425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VS_RS02430	COG0745	RESPONSE REGULATOR receiver
VS_RS02440	COG1283	sodium-dependent phosphate transmembrane transporter activity
VS_RS02445	COG0583	DNA-binding transcription factor activity
VS_RS02450	COG0640	Transcriptional regulator
VS_RS02455	COG0268	Binds directly to 16S ribosomal RNA
VS_RS02460	COG0728	peptidoglycan biosynthetic process
VS_RS02465	COG0196	riboflavin kinase activity
VS_RS02470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VS_RS02480	COG1047	Peptidyl-prolyl cis-trans
VS_RS02485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VS_RS02490	COG3279	Response regulator of the LytR AlgR family
VS_RS02495	COG3275	phosphorelay sensor kinase activity
VS_RS02500	COG1966	Carbon starvation protein
VS_RS02510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VS_RS02515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VS_RS02525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VS_RS02530	COG1605	Chorismate mutase
VS_RS02530	COG0287	Prephenate dehydrogenase
VS_RS02535	COG0739	heme binding
VS_RS02545	COG0488	(ABC) transporter
VS_RS02555	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VS_RS02560	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VS_RS02565	COG5001	Diguanylate cyclase
VS_RS02570	COG0077	Prephenate dehydratase
VS_RS02570	COG1605	Chorismate mutase
VS_RS02575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VS_RS02580	COG0741	lytic transglycosylase activity
VS_RS02585	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_RS02590	COG0564	pseudouridine synthase activity
VS_RS02595	COG1496	oxidoreductase activity
VS_RS02630	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
VS_RS02640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VS_RS02645	COG0826	peptidase U32
VS_RS02650	COG2974	May be involved in recombination
VS_RS02655	COG0745	RESPONSE REGULATOR receiver
VS_RS02660	COG5002	protein histidine kinase activity
VS_RS02670	COG0248	Ppx GppA phosphatase
VS_RS02675	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VS_RS02680	COG0573	inorganic phosphate transmembrane transporter activity
VS_RS02685	COG0581	inorganic phosphate transmembrane transporter activity
VS_RS02690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VS_RS02695	COG0704	Plays a role in the regulation of phosphate uptake
VS_RS02715	COG3142	Participates in the control of copper homeostasis
VS_RS02720	COG0450	alkyl hydroperoxide reductase
VS_RS02725	COG0583	DNA-binding transcription factor activity
VS_RS02735	COG0517	IMP dehydrogenase activity
VS_RS02740	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VS_RS02745	COG0343	queuine tRNA-ribosyltransferase activity
VS_RS02750	COG1862	Preprotein translocase
VS_RS02755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_RS02760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_RS02765	COG0483	inositol monophosphate 1-phosphatase activity
VS_RS02770	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VS_RS02775	COG1959	2 iron, 2 sulfur cluster binding
VS_RS02780	COG1104	cysteine desulfurase activity
VS_RS02785	COG0822	iron-sulfur transferase activity
VS_RS02795	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VS_RS02800	COG0443	Heat shock 70 kDa protein
VS_RS02810	COG2975	iron-sulfur cluster assembly
VS_RS02815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VS_RS02820	COG0105	UTP biosynthetic process
VS_RS02825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VS_RS02830	COG1426	Protein conserved in bacteria
VS_RS02835	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VS_RS02840	COG0124	histidyl-tRNA synthetase
VS_RS02845	COG2976	Protein conserved in bacteria
VS_RS02850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_RS02855	COG1160	GTP binding
VS_RS02860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VS_RS02865	COG3706	GGDEF domain
VS_RS02875	COG1570	exodeoxyribonuclease VII activity
VS_RS02880	COG0516	GMP reductase activity
VS_RS02880	COG0517	IMP dehydrogenase activity
VS_RS02885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VS_RS02885	COG0519	Catalyzes the synthesis of GMP from XMP
VS_RS02900	COG1584	GPR1 FUN34 yaaH family protein
VS_RS02905	COG1115	amino acid carrier protein
VS_RS02910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VS_RS02915	COG0204	Acyl-transferase
VS_RS02940	COG4067	protein conserved in archaea
VS_RS02940	COG0189	ligase activity
VS_RS02950	COG2867	negative regulation of translational initiation
VS_RS02955	COG2914	Belongs to the UPF0125 (RnfH) family
VS_RS02960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_RS02965	COG0497	DNA recombination
VS_RS02970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VS_RS02975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VS_RS02980	COG1301	dicarboxylic acid transport
VS_RS02985	COG0443	Heat shock 70 kDa protein
VS_RS02990	COG0484	heat shock protein binding
VS_RS03020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VS_RS03025	COG1253	flavin adenine dinucleotide binding
VS_RS03045	COG0047	phosphoribosylformylglycinamidine synthase activity
VS_RS03045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VS_RS03055	COG2171	N-acyltransferase activity
VS_RS03060	COG2095	MarC family integral membrane protein
VS_RS03075	COG3141	response to X-ray
VS_RS03090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VS_RS03095	COG1074	ATP-dependent DNA helicase activity
VS_RS03100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VS_RS03105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VS_RS03105	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VS_RS03115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VS_RS03120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VS_RS03125	COG2166	iron-sulfur cluster assembly
VS_RS03130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VS_RS03135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VS_RS03140	COG3248	Nucleoside-binding outer membrane protein
VS_RS03155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VS_RS03165	COG2813	Specifically methylates the guanine in position
VS_RS03170	COG0271	Belongs to the BolA IbaG family
VS_RS03175	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VS_RS03180	COG1805	sodium ion transport
VS_RS03190	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VS_RS03195	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VS_RS03200	COG2871	sodium ion transport
VS_RS03205	COG1477	protein flavinylation
VS_RS03210	COG2991	Protein conserved in bacteria
VS_RS03220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VS_RS03230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VS_RS03240	COG0733	neurotransmitter:sodium symporter activity
VS_RS03245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VS_RS03250	COG0321	lipoyl(octanoyl) transferase activity
VS_RS03260	COG1686	Belongs to the peptidase S11 family
VS_RS03265	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VS_RS03270	COG0772	Belongs to the SEDS family
VS_RS03275	COG0768	penicillin binding
VS_RS03280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VS_RS03285	COG0799	negative regulation of ribosome biogenesis
VS_RS03290	COG1466	dna polymerase III delta subunit
VS_RS03295	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VS_RS03300	COG0495	leucyl-tRNA aminoacylation
VS_RS03305	COG2888	peptidyl-tyrosine sulfation
VS_RS03310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VS_RS03315	COG4535	Mg2 and Co2 transporter CorC
VS_RS03320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VS_RS03325	COG1702	phosphate starvation-inducible protein PhoH
VS_RS03335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VS_RS03340	COG2706	6-phosphogluconolactonase activity
VS_RS03430	COG0012	GTP binding
VS_RS03435	COG0193	aminoacyl-tRNA hydrolase activity
VS_RS03440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VS_RS03445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VS_RS03450	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VS_RS03455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VS_RS03460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VS_RS03465	COG2890	protein-(glutamine-N5) methyltransferase activity
VS_RS03470	COG3094	Invasion gene expression up-regulator, SirB
VS_RS03475	COG2912	Transglutaminase-like superfamily
VS_RS03480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VS_RS03490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VS_RS03495	COG1187	pseudouridine synthase activity
VS_RS03500	COG2840	Smr protein MutS2
VS_RS03540	COG2608	mercury ion transmembrane transporter activity
VS_RS03540	COG2217	Heavy metal translocating P-type atpase
VS_RS03555	COG1028	Short-chain dehydrogenase reductase Sdr
VS_RS03590	COG2986	histidine ammonia-lyase
VS_RS03595	COG1216	Glycosyl transferase, family 2
VS_RS03615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VS_RS03620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VS_RS03680	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
VS_RS03685	COG0784	Response regulator, receiver
VS_RS03685	COG0835	chemotaxis
VS_RS03690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VS_RS03695	COG1815	bacterial-type flagellum-dependent cell motility
VS_RS03700	COG1558	bacterial-type flagellum-dependent cell motility
VS_RS03710	COG1749	Flagellar hook protein flgE
VS_RS03715	COG4787	bacterial-type flagellum-dependent cell motility
VS_RS03725	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VS_RS03730	COG1706	bacterial-type flagellum-dependent cell motility
VS_RS03735	COG3951	Flagellar rod assembly protein muramidase FlgJ
VS_RS03735	COG1705	Flagellar rod assembly protein muramidase FlgJ
VS_RS03755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_RS03760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_RS03770	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VS_RS03780	COG1516	flagellar protein fliS
VS_RS03800	COG1677	Flagellar hook-basal body complex protein FliE
VS_RS03810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VS_RS03860	COG1987	bacterial-type flagellum assembly
VS_RS03865	COG1684	flagellar biosynthetic protein fliR
VS_RS03905	COG0643	Histidine kinase
VS_RS03905	COG0784	Response regulator, receiver
VS_RS03905	COG2198	Histidine kinase
VS_RS03910	COG2201	protein-glutamate methylesterase activity
VS_RS03915	COG1192	Involved in chromosome partitioning
VS_RS03925	COG0835	chemotaxis
VS_RS03935	COG4133	protoheme IX ABC transporter activity
VS_RS03940	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VS_RS03945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VS_RS03950	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VS_RS03955	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VS_RS03960	COG1138	Cytochrome C-type biogenesis protein
VS_RS03965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VS_RS03970	COG3088	subunit of a heme lyase
VS_RS03970	COG4235	cytochrome complex assembly
VS_RS03975	COG4235	cytochrome complex assembly
VS_RS03975	COG3088	subunit of a heme lyase
VS_RS03985	COG2067	long-chain fatty acid transport protein
VS_RS03990	COG2067	long-chain fatty acid transport protein
VS_RS04005	COG0183	Belongs to the thiolase family
VS_RS04010	COG1250	3-hydroxyacyl-CoA dehydrogenase
VS_RS04010	COG1024	Enoyl-CoA hydratase
VS_RS04020	COG2062	phosphohistidine phosphatase, SixA
VS_RS04025	COG2840	Smr protein MutS2
VS_RS04030	COG2890	protein-(glutamine-N5) methyltransferase activity
VS_RS04035	COG1280	lysine exporter protein (LysE YggA)
VS_RS04040	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VS_RS04060	COG1175	transmembrane transport
VS_RS04070	COG3842	ATPase activity
VS_RS04080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VS_RS04085	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VS_RS04090	COG2894	cell division
VS_RS04095	COG0850	regulation of cytokinetic process
VS_RS04100	COG3100	YcgL domain-containing protein
VS_RS04105	COG2951	lytic endotransglycosylase activity
VS_RS04110	COG0583	DNA-binding transcription factor activity
VS_RS04115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VS_RS04125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VS_RS04140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VS_RS04145	COG2860	membrane
VS_RS04150	COG3101	peptidyl-lysine hydroxylation
VS_RS04160	COG0431	NADPH-dependent FMN reductase
VS_RS04170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VS_RS04175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VS_RS04180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VS_RS04190	COG0101	tRNA pseudouridine synthase activity
VS_RS04200	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VS_RS04205	COG0285	dihydrofolate synthase activity
VS_RS04210	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VS_RS04215	COG1286	toxin biosynthetic process
VS_RS04220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VS_RS04225	COG0583	DNA-binding transcription factor activity
VS_RS04230	COG0745	RESPONSE REGULATOR receiver
VS_RS04240	COG2832	Protein of unknown function (DUF454)
VS_RS04245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VS_RS04250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VS_RS04255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VS_RS04260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VS_RS04280	COG2983	Belongs to the UPF0260 family
VS_RS04285	COG1785	Belongs to the alkaline phosphatase family
VS_RS04305	COG2226	methyltransferase
VS_RS04320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VS_RS04325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VS_RS04335	COG3139	Protein of unknown function (DUF1315)
VS_RS04340	COG0252	asparaginase activity
VS_RS04345	COG0616	signal peptide processing
VS_RS04350	COG1902	pentaerythritol trinitrate reductase activity
VS_RS04350	COG0446	pyridine nucleotide-disulphide oxidoreductase
VS_RS04355	COG0778	Nitroreductase
VS_RS04360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VS_RS04375	COG0123	including yeast histone deacetylase and acetoin utilization protein
VS_RS04385	COG1959	2 iron, 2 sulfur cluster binding
VS_RS04400	COG3083	sulfuric ester hydrolase activity
VS_RS04405	COG3082	Protein of unknown function (DUF1414)
VS_RS04410	COG3081	Nucleoid-associated protein
VS_RS04425	COG1757	Na H antiporter
VS_RS04430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VS_RS04435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VS_RS04440	COG2095	MarC family integral membrane protein
VS_RS04445	COG1012	belongs to the aldehyde dehydrogenase family
VS_RS04445	COG1454	alcohol dehydrogenase
VS_RS04465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VS_RS04485	COG2056	Na+-H+ antiporter family
VS_RS04505	COG0346	lactoylglutathione lyase activity
VS_RS04510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VS_RS04515	COG4660	Part of a membrane complex involved in electron transport
VS_RS04520	COG4659	FMN binding
VS_RS04525	COG4658	electron transport chain
VS_RS04535	COG2878	Part of a membrane complex involved in electron transport
VS_RS04540	COG4657	Part of a membrane complex involved in electron transport
VS_RS04550	COG0556	nucleotide-excision repair
VS_RS04555	COG2204	response regulator
VS_RS04560	COG2198	Histidine kinase
VS_RS04565	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VS_RS04570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VS_RS04575	COG0521	Mo-molybdopterin cofactor biosynthetic process
VS_RS04580	COG0315	cyclic pyranopterin monophosphate synthase activity
VS_RS04585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VS_RS04590	COG0314	molybdopterin synthase activity
VS_RS04600	COG0601	transmembrane transport
VS_RS04605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_RS04610	COG0444	Belongs to the ABC transporter superfamily
VS_RS04620	COG0435	Glutathione S-transferase
VS_RS04630	COG0280	phosphate acetyltransferase
VS_RS04630	COG0857	belongs to the CobB CobQ family
VS_RS04635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VS_RS04640	COG3092	negative regulation of chromosome organization
VS_RS04650	COG3706	GGDEF domain
VS_RS04655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VS_RS04665	COG0653	protein targeting
VS_RS04675	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VS_RS04680	COG2186	Transcriptional regulator
VS_RS04690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VS_RS04690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VS_RS04695	COG0489	protein tyrosine kinase activity
VS_RS04700	COG0572	uridine kinase
VS_RS04705	COG2982	Protein involved in outer membrane biogenesis
VS_RS04710	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VS_RS04715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VS_RS04720	COG0659	secondary active sulfate transmembrane transporter activity
VS_RS04725	COG1530	ribonuclease E activity
VS_RS04730	COG0564	pseudouridine synthase activity
VS_RS04740	COG1399	metal-binding, possibly nucleic acid-binding protein
VS_RS04745	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VS_RS04750	COG0416	fatty acid biosynthetic process
VS_RS04755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VS_RS04780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VS_RS04785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VS_RS04790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VS_RS04800	COG0084	hydrolase, TatD family'
VS_RS04815	COG0733	neurotransmitter:sodium symporter activity
VS_RS04825	COG4667	esterase of the alpha-beta hydrolase superfamily
VS_RS04830	COG0469	pyruvate kinase activity
VS_RS04835	COG1940	carbohydrate kinase activity
VS_RS04840	COG0784	Response regulator, receiver
VS_RS04840	COG0835	chemotaxis
VS_RS04855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VS_RS04860	COG1028	Short-chain dehydrogenase reductase Sdr
VS_RS04865	COG0616	signal peptide processing
VS_RS04870	COG2719	SpoVR family
VS_RS04875	COG2718	Belongs to the UPF0229 family
VS_RS04880	COG2766	serine protein kinase
VS_RS04885	COG3713	MltA-interacting MipA family protein
VS_RS04890	COG3013	Belongs to the UPF0304 family
VS_RS04895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VS_RS04905	COG1882	Formate acetyltransferase
VS_RS04930	COG4160	amino acid transport
VS_RS04940	COG0708	Exodeoxyribonuclease III
VS_RS04945	COG1770	oligopeptidase
VS_RS04950	COG2814	Major facilitator Superfamily
VS_RS04955	COG0840	transmembrane signaling receptor activity
VS_RS04960	COG2850	peptidyl-arginine hydroxylation
VS_RS04980	COG1199	ATP-dependent helicase activity
VS_RS05000	COG1278	Cold shock
VS_RS05005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VS_RS05010	COG0542	response to heat
VS_RS05015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VS_RS05020	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VS_RS05025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VS_RS05035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VS_RS05045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VS_RS05050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VS_RS05055	COG0297	glycogen (starch) synthase activity
VS_RS05075	COG3070	regulator of competence-specific genes
VS_RS05080	COG1609	Transcriptional regulator
VS_RS05085	COG3381	protein complex oligomerization
VS_RS05090	COG0745	RESPONSE REGULATOR receiver
VS_RS05095	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VS_RS05100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VS_RS05105	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VS_RS05110	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VS_RS05115	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VS_RS05135	COG0189	ligase activity
VS_RS05135	COG4067	protein conserved in archaea
VS_RS05140	COG0500	methyltransferase
VS_RS05145	COG4106	trans-aconitate 2-methyltransferase activity
VS_RS05150	COG1801	Protein of unknown function DUF72
VS_RS05155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VS_RS05160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VS_RS05165	COG0840	transmembrane signaling receptor activity
VS_RS05170	COG0632	four-way junction helicase activity
VS_RS05175	COG2255	four-way junction helicase activity
VS_RS05180	COG1271	oxidase subunit
VS_RS05185	COG1294	oxidase, subunit
VS_RS05200	COG0824	Thioesterase
VS_RS05205	COG0811	peptide transport
VS_RS05220	COG0823	Involved in the tonB-independent uptake of proteins
VS_RS05225	COG2885	chlorophyll binding
VS_RS05230	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VS_RS05235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VS_RS05240	COG4774	siderophore transport
VS_RS05240	COG1629	transport
VS_RS05245	COG2375	cellular response to nickel ion
VS_RS05250	COG4592	Periplasmic binding protein
VS_RS05255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_RS05260	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_RS05265	COG1120	ATPase activity
VS_RS05280	COG5002	protein histidine kinase activity
VS_RS05280	COG0784	Response regulator, receiver
VS_RS05295	COG0583	DNA-binding transcription factor activity
VS_RS05300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VS_RS05320	COG0745	RESPONSE REGULATOR receiver
VS_RS05325	COG0463	Glycosyl transferase, family 2
VS_RS05330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VS_RS05340	COG1032	radical SAM domain protein
VS_RS05355	COG0583	DNA-binding transcription factor activity
VS_RS05360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VS_RS05370	COG2350	Protein conserved in bacteria
VS_RS05375	COG1607	acyl-coa hydrolase
VS_RS05380	COG2917	probably involved in intracellular septation
VS_RS05420	COG3706	GGDEF domain
VS_RS05420	COG5001	Diguanylate cyclase
VS_RS05420	COG2203	Gaf domain
VS_RS05420	COG4251	negative regulation of phosphorylation
VS_RS05425	COG0840	transmembrane signaling receptor activity
VS_RS05445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VS_RS05450	COG4136	ATPase activity
VS_RS05455	COG4135	transport system, permease component
VS_RS05460	COG4134	Bacterial extracellular solute-binding protein
VS_RS05470	COG3313	Fe-S protein
VS_RS05485	COG0513	Belongs to the DEAD box helicase family
VS_RS05490	COG1280	lysine exporter protein (LysE YggA)
VS_RS05500	COG2866	Carboxypeptidase
VS_RS05525	COG4176	ABC-type proline glycine betaine transport system permease component
VS_RS05530	COG2113	Glycine betaine
VS_RS05540	COG0583	DNA-binding transcription factor activity
VS_RS05545	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VS_RS05550	COG4988	ABC transporter
VS_RS05555	COG0492	ferredoxin-NADP+ reductase activity
VS_RS05585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VS_RS05600	COG2199	diguanylate cyclase activity
VS_RS05600	COG2203	Gaf domain
VS_RS05620	COG0471	metal ion transport
VS_RS05625	COG2949	membrane
VS_RS05630	COG0281	malic enzyme
VS_RS05635	COG1643	Atp-dependent helicase
VS_RS05645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VS_RS05680	COG0277	FAD linked oxidase domain protein
VS_RS05680	COG0247	lactate metabolic process
VS_RS05700	COG2986	histidine ammonia-lyase
VS_RS05705	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VS_RS05710	COG0010	Belongs to the arginase family
VS_RS05715	COG1228	amidohydrolase
VS_RS05725	COG4326	sporulation control protein
VS_RS05760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VS_RS05765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VS_RS05770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VS_RS05775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VS_RS05780	COG3097	Belongs to the UPF0267 family
VS_RS05795	COG0488	(ABC) transporter
VS_RS05800	COG1309	transcriptional regulator
VS_RS05810	COG1166	arginine decarboxylase activity
VS_RS05815	COG0010	Belongs to the arginase family
VS_RS05825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_RS05830	COG0800	Aldolase
VS_RS05835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_RS05840	COG1917	Cupin 2, conserved barrel domain protein
VS_RS05865	COG2186	Transcriptional regulator
VS_RS05870	COG2186	Transcriptional regulator
VS_RS05875	COG0517	IMP dehydrogenase activity
VS_RS05880	COG2176	DNA-directed DNA polymerase activity
VS_RS05895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_RS05975	COG0471	metal ion transport
VS_RS05980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_RS05980	COG4191	Histidine kinase
VS_RS06030	COG0730	response to heat
VS_RS06055	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VS_RS06060	COG1280	lysine exporter protein (LysE YggA)
VS_RS06065	COG1115	amino acid carrier protein
VS_RS06085	COG1115	amino acid carrier protein
VS_RS06100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_RS06115	COG3290	protein histidine kinase activity
VS_RS06120	COG4565	transcriptional regulatory protein
VS_RS06125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VS_RS06130	COG0363	glucosamine-6-phosphate deaminase activity
VS_RS06135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VS_RS06145	COG4628	conserved protein (DUF2132)
VS_RS06180	COG3437	response regulator, receiver
VS_RS06295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VS_RS06305	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VS_RS06310	COG0372	Belongs to the citrate synthase family
VS_RS06315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VS_RS06320	COG2828	Protein conserved in bacteria
VS_RS06350	COG0561	phosphatase activity
VS_RS06355	COG0602	queuosine metabolic process
VS_RS06360	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VS_RS06365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VS_RS06390	COG0484	heat shock protein binding
VS_RS06450	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
VS_RS06490	COG1196	nuclear chromosome segregation
VS_RS06520	COG3706	GGDEF domain
VS_RS06530	COG3047	cAMP biosynthetic process
VS_RS06530	COG2885	chlorophyll binding
VS_RS06550	COG0840	transmembrane signaling receptor activity
VS_RS06555	COG1254	Belongs to the acylphosphatase family
VS_RS06560	COG2920	part of a sulfur-relay system
VS_RS06565	COG0670	Belongs to the BI1 family
VS_RS06570	COG1126	abc transporter atp-binding protein
VS_RS06575	COG0765	amino acid transport
VS_RS06580	COG4597	amino acid ABC transporter
VS_RS06585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_RS06595	COG1666	GTP binding
VS_RS06600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VS_RS06605	COG0574	Belongs to the PEP-utilizing enzyme family
VS_RS06605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VS_RS06620	COG2996	Protein conserved in bacteria
VS_RS06625	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VS_RS06625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VS_RS06630	COG3008	intermembrane lipid transfer
VS_RS06635	COG2995	paraquat-inducible protein a
VS_RS06640	COG1132	(ABC) transporter
VS_RS06645	COG1956	GAF domain-containing protein
VS_RS06650	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VS_RS06665	COG0308	aminopeptidase N
VS_RS06670	COG2902	Dehydrogenase
VS_RS06675	COG0167	dihydroorotate dehydrogenase activity
VS_RS06685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VS_RS06685	COG0116	Belongs to the methyltransferase superfamily
VS_RS06695	COG0488	(ABC) transporter
VS_RS06715	COG1067	ATP-dependent peptidase activity
VS_RS06720	COG3120	sequence-specific DNA binding
VS_RS06790	COG2801	Transposase and inactivated derivatives
VS_RS06815	COG2801	Transposase and inactivated derivatives
VS_RS06820	COG0784	Response regulator, receiver
VS_RS06820	COG5002	protein histidine kinase activity
VS_RS06835	COG3278	Belongs to the heme-copper respiratory oxidase family
VS_RS06850	COG2010	Cytochrome c
VS_RS06860	COG2217	Heavy metal translocating P-type atpase
VS_RS06875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VS_RS06880	COG0589	response to stress
VS_RS06885	COG0037	tRNA processing
VS_RS06905	COG3842	ATPase activity
VS_RS06915	COG1177	transmembrane transport
VS_RS06925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VS_RS06935	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VS_RS06940	COG0004	ammonium transporteR
VS_RS06955	COG0437	4 iron, 4 sulfur cluster binding
VS_RS06960	COG0243	molybdopterin cofactor binding
VS_RS06960	COG3383	formate dehydrogenase (NAD+) activity
VS_RS06970	COG3381	protein complex oligomerization
VS_RS06990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VS_RS07010	COG4191	Histidine kinase
VS_RS07015	COG2204	response regulator
VS_RS07025	COG4662	Binding-protein-dependent transport system inner membrane component
VS_RS07030	COG3842	ATPase activity
VS_RS07035	COG0746	molybdenum cofactor guanylyltransferase activity
VS_RS07040	COG0303	'Molybdopterin
VS_RS07045	COG3706	GGDEF domain
VS_RS07055	COG1940	carbohydrate kinase activity
VS_RS07060	COG3148	PFAM DTW domain containing protein
VS_RS07075	COG0791	NLP P60 protein
VS_RS07090	COG0307	riboflavin synthase, alpha
VS_RS07095	COG0534	Mate efflux family protein
VS_RS07100	COG1793	dna ligase
VS_RS07110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VS_RS07110	COG2885	chlorophyll binding
VS_RS07130	COG4176	ABC-type proline glycine betaine transport system permease component
VS_RS07135	COG4175	Glycine betaine
VS_RS07135	COG3448	diguanylate cyclase activity
VS_RS07145	COG2204	response regulator
VS_RS07150	COG0438	transferase activity, transferring glycosyl groups
VS_RS07175	COG0438	transferase activity, transferring glycosyl groups
VS_RS07180	COG1215	transferase activity, transferring glycosyl groups
VS_RS07185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VS_RS07250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_RS07255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VS_RS07280	COG0517	IMP dehydrogenase activity
VS_RS07285	COG4160	amino acid transport
VS_RS07290	COG4215	(ABC) transporter
VS_RS07295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_RS07300	COG1126	abc transporter atp-binding protein
VS_RS07315	COG0826	peptidase U32
VS_RS07330	COG0786	glutamate:sodium symporter activity
VS_RS07360	COG1028	Short-chain dehydrogenase reductase Sdr
VS_RS07370	COG0546	phosphoglycolate phosphatase activity
VS_RS07375	COG0653	protein targeting
VS_RS07395	COG0346	lactoylglutathione lyase activity
VS_RS07400	COG1280	lysine exporter protein (LysE YggA)
VS_RS07425	COG1051	belongs to the nudix hydrolase family
VS_RS07440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VS_RS07470	COG1187	pseudouridine synthase activity
VS_RS07485	COG0494	nUDIX hydrolase
VS_RS07510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VS_RS07520	COG0584	glycerophosphoryl diester phosphodiesterase
VS_RS07525	COG2271	Major facilitator Superfamily
VS_RS07555	COG0589	response to stress
VS_RS07560	COG0415	Belongs to the DNA photolyase family
VS_RS07565	COG3046	protein related to deoxyribodipyrimidine photolyase
VS_RS07580	COG0419	ATPase involved in DNA repair
VS_RS07585	COG0420	3'-5' exonuclease activity
VS_RS07605	COG0454	-acetyltransferase
VS_RS07610	COG2199	diguanylate cyclase activity
VS_RS07620	COG4771	TonB-dependent receptor
VS_RS07635	COG0840	transmembrane signaling receptor activity
VS_RS07650	COG3119	arylsulfatase activity
VS_RS07660	COG0583	DNA-binding transcription factor activity
VS_RS07665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VS_RS07695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VS_RS07705	COG0210	DNA helicase
VS_RS07720	COG0328	RNA-DNA hybrid ribonuclease activity
VS_RS07730	COG2003	Belongs to the UPF0758 family
VS_RS07790	COG0582	viral genome integration into host DNA
VS_RS07810	COG3706	GGDEF domain
VS_RS07815	COG2195	Cleaves the N-terminal amino acid of tripeptides
VS_RS07830	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VS_RS07835	COG3063	Type IV pilus biogenesis stability protein PilW
VS_RS07845	COG1451	nucleotide metabolic process
VS_RS07855	COG0583	DNA-binding transcription factor activity
VS_RS07860	COG2814	Major facilitator Superfamily
VS_RS07880	COG1247	-acetyltransferase
VS_RS07890	COG1294	oxidase, subunit
VS_RS07895	COG1271	oxidase subunit
VS_RS07900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_RS07915	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VS_RS07920	COG4139	cobalamin transport
VS_RS07925	COG2988	succinylglutamate desuccinylase activity
VS_RS07945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VS_RS07950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VS_RS07955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VS_RS07960	COG0702	epimerase
VS_RS07965	COG1823	symporter activity
VS_RS07975	COG3122	Protein conserved in bacteria
VS_RS07980	COG3568	Endonuclease Exonuclease Phosphatase
VS_RS08005	COG2925	Exonuclease
VS_RS08015	COG1346	cytolysis
VS_RS08020	COG0295	cytidine deaminase activity
VS_RS08025	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VS_RS08030	COG0500	methyltransferase
VS_RS08040	COG0776	regulation of translation
VS_RS08050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_RS08065	COG2175	clavaminate synthase activity
VS_RS08075	COG0840	transmembrane signaling receptor activity
VS_RS08105	COG0776	regulation of translation
VS_RS08120	COG1342	Belongs to the UPF0251 family
VS_RS08135	COG2873	o-acetylhomoserine
VS_RS08140	COG1522	sequence-specific DNA binding
VS_RS08155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_RS08160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VS_RS08245	COG0072	phenylalanine-tRNA ligase activity
VS_RS08245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VS_RS08250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VS_RS08290	COG1643	Atp-dependent helicase
VS_RS08320	COG3710	Transcriptional regulator
VS_RS08340	COG3706	GGDEF domain
VS_RS08370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VS_RS08385	COG3106	COG3106 Predicted ATPase
VS_RS08410	COG5002	protein histidine kinase activity
VS_RS08410	COG0784	Response regulator, receiver
VS_RS08420	COG0494	nUDIX hydrolase
VS_RS08425	COG0814	amino acid
VS_RS08430	COG1760	l-serine dehydratase
VS_RS08435	COG0814	amino acid
VS_RS08440	COG0720	synthase
VS_RS08445	COG0840	transmembrane signaling receptor activity
VS_RS08450	COG0659	secondary active sulfate transmembrane transporter activity
VS_RS08455	COG0017	Asparaginyl-tRNA synthetase
VS_RS08480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_RS08490	COG3437	response regulator, receiver
VS_RS08490	COG2770	Histidine kinase
VS_RS08505	COG1448	Aminotransferase
VS_RS08520	COG2176	DNA-directed DNA polymerase activity
VS_RS08525	COG2258	MOSC domain
VS_RS08530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VS_RS08540	COG4191	Histidine kinase
VS_RS08545	COG2204	response regulator
VS_RS08555	COG3070	regulator of competence-specific genes
VS_RS08570	COG2431	L-lysine efflux transmembrane transporter activity
VS_RS08580	COG0076	glutamate decarboxylase activity
VS_RS08585	COG1737	Transcriptional regulator
VS_RS08595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VS_RS08600	COG2985	domain, Protein
VS_RS08600	COG3273	potassium ion transport
VS_RS08635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VS_RS08660	COG0702	epimerase
VS_RS08670	COG2814	Major facilitator Superfamily
VS_RS08680	COG1061	Type III restriction enzyme res subunit
VS_RS08685	COG5002	protein histidine kinase activity
VS_RS08685	COG5001	Diguanylate cyclase
VS_RS08700	COG0642	Histidine kinase
VS_RS08705	COG0586	Pfam SNARE associated Golgi protein
VS_RS08715	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VS_RS08755	COG3547	Transposase (IS116 IS110 IS902 family)
VS_RS08770	COG2801	Transposase and inactivated derivatives
VS_RS08785	COG0494	nUDIX hydrolase
VS_RS08800	COG3547	Transposase (IS116 IS110 IS902 family)
VS_RS08830	COG2732	(Barnase) inhibitor
VS_RS08855	COG2124	cytochrome p450
VS_RS08890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VS_RS08895	COG1780	Probably involved in ribonucleotide reductase function
VS_RS08905	COG0316	Belongs to the HesB IscA family
VS_RS08910	COG0719	Fe-S assembly protein
VS_RS08915	COG0396	ATPase activity
VS_RS08920	COG0719	Fe-S assembly protein
VS_RS08925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VS_RS08930	COG2166	iron-sulfur cluster assembly
VS_RS08935	COG0840	transmembrane signaling receptor activity
VS_RS08940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_RS08945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_RS08970	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VS_RS08985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VS_RS08990	COG3108	Peptidase M15
VS_RS08995	COG2989	Protein conserved in bacteria
VS_RS09020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VS_RS09030	COG3088	subunit of a heme lyase
VS_RS09030	COG4235	cytochrome complex assembly
VS_RS09040	COG1138	Cytochrome C-type biogenesis protein
VS_RS09045	COG3301	Polysulphide reductase, NrfD
VS_RS09050	COG0437	4 iron, 4 sulfur cluster binding
VS_RS09055	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VS_RS09060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VS_RS09065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VS_RS09080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VS_RS09085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VS_RS09090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VS_RS09115	COG0019	diaminopimelate decarboxylase activity
VS_RS09160	COG2197	response regulator
VS_RS09165	COG0417	DNA replication proofreading
VS_RS09175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VS_RS09190	COG1187	pseudouridine synthase activity
VS_RS09195	COG0009	L-threonylcarbamoyladenylate synthase
VS_RS09200	COG0613	PHP domain protein
VS_RS09210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VS_RS09215	COG0512	Glutamine amidotransferase of anthranilate synthase
VS_RS09220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VS_RS09225	COG0135	phosphoribosylanthranilate isomerase activity
VS_RS09225	COG0134	indole-3-glycerol-phosphate synthase activity
VS_RS09230	COG0133	tryptophan synthase activity
VS_RS09235	COG0159	tryptophan synthase activity
VS_RS09240	COG0330	HflC and HflK could
VS_RS09250	COG1301	dicarboxylic acid transport
VS_RS09265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VS_RS09265	COG0116	Belongs to the methyltransferase superfamily
VS_RS09270	COG0564	pseudouridine synthase activity
VS_RS09280	COG0733	neurotransmitter:sodium symporter activity
VS_RS09290	COG0626	cystathionine gamma-synthase activity
VS_RS09305	COG2818	Glycosylase
VS_RS09320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_RS09325	COG1983	PspC domain protein
VS_RS09335	COG1842	Phage shock protein A
VS_RS09340	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VS_RS09345	COG4166	transmembrane transport
VS_RS09350	COG4168	peptide transport system, permease
VS_RS09365	COG4172	Belongs to the ABC transporter superfamily
VS_RS09380	COG1227	inorganic diphosphatase activity
VS_RS09390	COG0243	molybdopterin cofactor binding
VS_RS09395	COG3005	denitrification pathway
VS_RS09400	COG4459	periplasmic nitrate reductase
VS_RS09405	COG0390	transport system, permease component
VS_RS09410	COG2116	formate transmembrane transporter activity
VS_RS09440	COG0215	cysteine-tRNA ligase activity
VS_RS09445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VS_RS09450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VS_RS09455	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VS_RS09460	COG3012	SEC-C Motif Domain Protein
VS_RS09465	COG0140	phosphoribosyl-ATP diphosphatase activity
VS_RS09465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VS_RS09470	COG0107	imidazoleglycerol-phosphate synthase activity
VS_RS09475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VS_RS09480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VS_RS09485	COG0131	Imidazoleglycerol-phosphate dehydratase
VS_RS09485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VS_RS09490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VS_RS09505	COG1757	Na H antiporter
VS_RS09510	COG2916	Histone family protein nucleoid-structuring protein H-NS
VS_RS09515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_RS09530	COG2915	High frequency lysogenization protein hflD homolog
VS_RS09535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VS_RS09540	COG0501	Belongs to the peptidase M48B family
VS_RS09555	COG0156	8-amino-7-oxononanoate synthase activity
VS_RS09560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VS_RS09565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VS_RS09575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VS_RS09580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VS_RS09590	COG1674	ftsk spoiiie
VS_RS09595	COG1522	sequence-specific DNA binding
VS_RS09600	COG0686	Belongs to the AlaDH PNT family
VS_RS09610	COG0583	DNA-binding transcription factor activity
VS_RS09625	COG0284	orotidine-5'-phosphate decarboxylase activity
VS_RS09630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VS_RS09635	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VS_RS09640	COG0776	regulation of translation
VS_RS09645	COG0539	negative regulation of cytoplasmic translation
VS_RS09650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VS_RS09655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VS_RS09660	COG2835	tetraacyldisaccharide 4'-kinase activity
VS_RS09665	COG1663	tetraacyldisaccharide 4'-kinase activity
VS_RS09670	COG1132	(ABC) transporter
VS_RS09675	COG0658	competence protein
VS_RS09675	COG2333	competence protein COMEC
VS_RS09685	COG4591	ABC-type transport system involved in lipoprotein release permease component
VS_RS09690	COG1136	(ABC) transporter
VS_RS09695	COG4591	ABC-type transport system involved in lipoprotein release permease component
VS_RS09705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VS_RS09720	COG1252	NADH dehydrogenase
VS_RS09725	COG3150	esterase
VS_RS09750	COG0537	adenosine 5'-monophosphoramidase activity
VS_RS09780	COG0517	IMP dehydrogenase activity
VS_RS09780	COG0617	tRNA 3'-terminal CCA addition
VS_RS09780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VS_RS09805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VS_RS09810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VS_RS09825	COG1902	pentaerythritol trinitrate reductase activity
VS_RS09830	COG0346	lactoylglutathione lyase activity
VS_RS09855	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VS_RS09865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_RS09875	COG1309	transcriptional regulator
VS_RS09880	COG0583	DNA-binding transcription factor activity
VS_RS09895	COG3040	lipid binding
VS_RS09900	COG1574	metal-dependent hydrolase with the TIM-barrel fold
VS_RS09910	COG1120	ATPase activity
VS_RS09915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VS_RS09945	COG3118	belongs to the thioredoxin family
VS_RS09950	COG4232	protein-disulfide reductase activity
VS_RS09970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VS_RS09990	COG1280	lysine exporter protein (LysE YggA)
VS_RS09995	COG1522	sequence-specific DNA binding
VS_RS10010	COG0789	Transcriptional regulator
VS_RS10015	COG0583	DNA-binding transcription factor activity
VS_RS10055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VS_RS10085	COG1216	Glycosyl transferase, family 2
VS_RS10085	COG0463	Glycosyl transferase, family 2
VS_RS10090	COG0438	transferase activity, transferring glycosyl groups
VS_RS10095	COG3341	Caulimovirus viroplasmin
VS_RS10095	COG0328	RNA-DNA hybrid ribonuclease activity
VS_RS10125	COG4106	trans-aconitate 2-methyltransferase activity
VS_RS10140	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VS_RS10145	COG1946	Acyl-CoA thioesterase
VS_RS10155	COG1522	sequence-specific DNA binding
VS_RS10170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_RS10230	COG2855	membrane
VS_RS10245	COG1263	PTS System
VS_RS10245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_RS10245	COG2190	(PTS) system
VS_RS10260	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VS_RS10265	COG2267	carboxylic ester hydrolase activity
VS_RS10270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VS_RS10275	COG1169	isochorismate synthase
VS_RS10280	COG0436	Aminotransferase
VS_RS10285	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VS_RS10290	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VS_RS10305	COG1555	photosystem II stabilization
VS_RS10310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VS_RS10315	COG0776	regulation of translation
VS_RS10320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VS_RS10325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VS_RS10330	COG0740	serine-type endopeptidase activity
VS_RS10335	COG0544	peptidyl-prolyl cis-trans isomerase activity
VS_RS10345	COG2204	response regulator
VS_RS10350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VS_RS10355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VS_RS10360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VS_RS10380	COG3321	synthase
VS_RS10380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VS_RS10395	COG2070	2-Nitropropane dioxygenase
VS_RS10395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VS_RS10400	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VS_RS10405	COG0318	PFAM AMP-dependent synthetase and ligase
VS_RS10410	COG2267	carboxylic ester hydrolase activity
VS_RS10425	COG1214	PFAM Peptidase M22, glycoprotease
VS_RS10430	COG1199	ATP-dependent helicase activity
VS_RS10440	COG0788	formyltetrahydrofolate deformylase activity
VS_RS10445	COG3102	Protein conserved in bacteria
VS_RS10450	COG0018	arginyl-trna synthetase
VS_RS10470	COG1918	ferrous iron import across plasma membrane
VS_RS10485	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VS_RS10490	COG1121	(ABC) transporter
VS_RS10495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VS_RS10505	COG0045	succinate-CoA ligase (ADP-forming) activity
VS_RS10510	COG0508	dehydrogenase complex catalyzes the overall conversion of
VS_RS10515	COG0567	Dehydrogenase, E1 component
VS_RS10530	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VS_RS10540	COG0372	Belongs to the citrate synthase family
VS_RS10545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VS_RS10555	COG0033	Phosphoglucomutase
VS_RS10560	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VS_RS10565	COG0596	Alpha beta hydrolase
VS_RS10590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VS_RS10595	COG1263	PTS System
VS_RS10595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_RS10595	COG2190	(PTS) system
VS_RS10600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VS_RS10605	COG1940	carbohydrate kinase activity
VS_RS10605	COG1846	Transcriptional regulator
VS_RS10610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VS_RS10610	COG4651	solute:proton antiporter activity
VS_RS10615	COG0367	asparagine synthase
VS_RS10620	COG0250	Participates in transcription elongation, termination and antitermination
VS_RS10625	COG3104	oligopeptide transport
VS_RS10630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VS_RS10635	COG0563	adenylate kinase activity
VS_RS10640	COG0326	Molecular chaperone. Has ATPase activity
VS_RS10645	COG3710	Transcriptional regulator
VS_RS10660	COG0622	Phosphoesterase
VS_RS10685	COG1090	epimerase
VS_RS10690	COG0300	oxidoreductase activity
VS_RS10695	COG3118	belongs to the thioredoxin family
VS_RS10700	COG0330	HflC and HflK could
VS_RS10710	COG0789	Transcriptional regulator
VS_RS10725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VS_RS10735	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VS_RS10745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS10755	COG2190	(PTS) system
VS_RS10760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_RS10765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_RS10770	COG2837	iron assimilation
VS_RS10795	COG1393	Belongs to the ArsC family
VS_RS10800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VS_RS10815	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VS_RS10820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VS_RS10830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VS_RS10845	COG4783	chaperone-mediated protein folding
VS_RS10850	COG1393	Belongs to the ArsC family
VS_RS10870	COG2233	PERMEase
VS_RS10875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VS_RS10880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VS_RS10885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VS_RS10890	COG0121	glutamine amidotransferase
VS_RS10895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VS_RS10900	COG1960	acyl-CoA dehydrogenase activity
VS_RS10910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VS_RS10915	COG0328	RNA-DNA hybrid ribonuclease activity
VS_RS10930	COG2226	methyltransferase
VS_RS10935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VS_RS10940	COG0741	lytic transglycosylase activity
VS_RS10940	COG1388	LysM domain
VS_RS10950	COG3021	interspecies interaction between organisms
VS_RS10955	COG0347	Belongs to the P(II) protein family
VS_RS10965	COG0037	tRNA processing
VS_RS10970	COG0825	malonyl-CoA metabolic process
VS_RS10975	COG0587	DNA-directed DNA polymerase activity
VS_RS10980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VS_RS10990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VS_RS10995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VS_RS11000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VS_RS11005	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VS_RS11015	COG0750	zinc metalloprotease
VS_RS11025	COG0575	Belongs to the CDS family
VS_RS11030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VS_RS11040	COG0233	cytoplasmic translational termination
VS_RS11045	COG0528	UMP kinase activity
VS_RS11050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VS_RS11055	COG0052	Belongs to the universal ribosomal protein uS2 family
VS_RS11060	COG0024	Methionine aminopeptidase
VS_RS11065	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VS_RS11075	COG0564	pseudouridine synthase activity
VS_RS11080	COG3098	single-species biofilm formation
VS_RS11105	COG1671	Belongs to the UPF0178 family
VS_RS11110	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VS_RS11115	COG0254	rRNA binding
VS_RS11120	COG1720	tRNA m6t6A37 methyltransferase activity
VS_RS11125	COG0442	prolyl-tRNA aminoacylation
VS_RS11150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VS_RS11155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VS_RS11170	COG0366	Alpha amylase catalytic
VS_RS11175	COG1263	PTS System
VS_RS11175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_RS11180	COG1609	Transcriptional regulator
VS_RS11190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VS_RS11195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VS_RS11200	COG2011	ABC-type metal ion transport system permease component
VS_RS11205	COG1464	Belongs to the NlpA lipoprotein family
VS_RS11225	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VS_RS11235	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VS_RS11235	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VS_RS11250	COG1611	Belongs to the LOG family
VS_RS11255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VS_RS11265	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VS_RS11280	COG0583	DNA-binding transcription factor activity
VS_RS11285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VS_RS11285	COG0301	tRNA thio-modification
VS_RS11295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VS_RS11300	COG1722	exodeoxyribonuclease VII activity
VS_RS11305	COG0142	geranyltranstransferase activity
VS_RS11310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VS_RS11315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VS_RS11320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VS_RS11325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VS_RS11345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VS_RS11345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VS_RS11350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VS_RS11355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VS_RS11375	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VS_RS11380	COG2252	PERMEase
VS_RS11390	COG2195	Cleaves the N-terminal amino acid of tripeptides
VS_RS11420	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VS_RS11425	COG0583	DNA-binding transcription factor activity
VS_RS11430	COG2059	Chromate
VS_RS11435	COG2226	methyltransferase
VS_RS11495	COG4964	Belongs to the GSP D family
VS_RS11525	COG1022	Amp-dependent synthetase and ligase
VS_RS11535	COG0583	DNA-binding transcription factor activity
VS_RS11540	COG4628	conserved protein (DUF2132)
VS_RS11545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VS_RS11550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VS_RS11560	COG0560	Phosphoserine phosphatase
VS_RS11570	COG0813	purine-nucleoside phosphorylase activity
VS_RS11575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VS_RS11580	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VS_RS11585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VS_RS11590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VS_RS11595	COG0084	hydrolase, TatD family'
VS_RS11600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VS_RS11615	COG3153	acetyltransferase
VS_RS11620	COG3154	lipid carrier protein
VS_RS11630	COG0826	peptidase U32
VS_RS11635	COG0826	peptidase U32
VS_RS11640	COG0534	Mate efflux family protein
VS_RS11655	COG1185	polyribonucleotide nucleotidyltransferase activity
VS_RS11660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VS_RS11665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VS_RS11670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VS_RS11675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VS_RS11680	COG0195	Participates in both transcription termination and antitermination
VS_RS11685	COG0779	Required for maturation of 30S ribosomal subunits
VS_RS11700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VS_RS11705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VS_RS11710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VS_RS11715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VS_RS11720	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VS_RS11725	COG1534	Rna-binding protein
VS_RS11730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VS_RS11740	COG2027	D-alanyl-D-alanine carboxypeptidase
VS_RS11745	COG2239	Acts as a magnesium transporter
VS_RS11750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VS_RS11755	COG0739	heme binding
VS_RS11770	COG0316	Belongs to the HesB IscA family
VS_RS11775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VS_RS11785	COG0628	permease
VS_RS11790	COG2813	Specifically methylates the guanine in position
VS_RS11800	COG0747	negative chemotaxis
VS_RS11810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_RS11815	COG0444	Belongs to the ABC transporter superfamily
VS_RS11820	COG4608	Belongs to the ABC transporter superfamily
VS_RS11830	COG2971	BadF BadG BcrA BcrD
VS_RS11845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VS_RS11850	COG3842	ATPase activity
VS_RS11860	COG1840	ABC-type Fe3 transport system, periplasmic component
VS_RS11865	COG0004	ammonium transporteR
VS_RS11880	COG1049	propionate catabolic process, 2-methylcitrate cycle
VS_RS11885	COG1752	Esterase of the alpha-beta hydrolase superfamily
VS_RS11890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VS_RS11895	COG1643	Atp-dependent helicase
VS_RS11900	COG1489	DNA binding
VS_RS11920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_RS11925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VS_RS11930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VS_RS11935	COG0842	Transport permease protein
VS_RS11940	COG1131	(ABC) transporter
VS_RS11945	COG0659	secondary active sulfate transmembrane transporter activity
VS_RS11950	COG0288	reversible hydration of carbon dioxide
VS_RS11965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VS_RS11970	COG0508	dehydrogenase complex catalyzes the overall conversion of
VS_RS11975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VS_RS11980	COG2186	Transcriptional regulator
VS_RS12000	COG0157	Belongs to the NadC ModD family
VS_RS12010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VS_RS12015	COG1459	type II secretion system
VS_RS12030	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VS_RS12040	COG0335	large ribosomal subunit rRNA binding
VS_RS12045	COG0336	Belongs to the RNA methyltransferase TrmD family
VS_RS12050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VS_RS12055	COG0228	four-way junction DNA binding
VS_RS12060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VS_RS12065	COG4137	Cytochrome C assembly protein
VS_RS12070	COG4536	flavin adenine dinucleotide binding
VS_RS12075	COG1854	S-ribosylhomocysteine lyase activity
VS_RS12090	COG0612	Peptidase, M16
VS_RS12095	COG1238	metal cluster binding
VS_RS12105	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VS_RS12110	COG5016	pyruvate
VS_RS12110	COG0511	ligase activity, forming carbon-carbon bonds
VS_RS12115	COG3630	sodium ion export across plasma membrane
VS_RS12170	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VS_RS12175	COG0527	aspartate kinase activity
VS_RS12190	COG3842	ATPase activity
VS_RS12200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VS_RS12210	COG2182	Extracellular solute-binding protein
VS_RS12215	COG1175	transmembrane transport
VS_RS12220	COG3833	ABC-type maltose transport systems, permease component
VS_RS12240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VS_RS12245	COG1546	Belongs to the CinA family
VS_RS12250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VS_RS12255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VS_RS12265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VS_RS12270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VS_RS12275	COG0585	pseudouridine synthase activity
VS_RS12285	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VS_RS12290	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VS_RS12295	COG0148	phosphopyruvate hydratase activity
VS_RS12300	COG0504	CTP synthase activity
VS_RS12305	COG3956	TIGRFAM MazG family protein
VS_RS12310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VS_RS12315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VS_RS12320	COG2205	protein histidine kinase activity
VS_RS12320	COG3437	response regulator, receiver
VS_RS12320	COG4999	Histidine kinase
VS_RS12320	COG3850	Histidine kinase
VS_RS12325	COG0736	holo-[acyl-carrier-protein] synthase activity
VS_RS12330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VS_RS12335	COG1381	Involved in DNA repair and RecF pathway recombination
VS_RS12340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VS_RS12345	COG0571	ribonuclease III activity
VS_RS12355	COG0481	GTPase activity
VS_RS12375	COG1595	DNA-templated transcription, initiation
VS_RS12380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VS_RS12385	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VS_RS12390	COG0354	folic acid binding
VS_RS12405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VS_RS12410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VS_RS12415	COG3079	Belongs to the UPF0149 family
VS_RS12420	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VS_RS12425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VS_RS12430	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VS_RS12435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VS_RS12450	COG1279	arginine transmembrane transporter activity
VS_RS12455	COG0668	transmembrane transport
VS_RS12460	COG0191	fructose-bisphosphate aldolase activity
VS_RS12480	COG1653	transport
VS_RS12485	COG0642	Histidine kinase
VS_RS12500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VS_RS12505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VS_RS12520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_RS12525	COG0588	phosphoglycerate mutase activity
VS_RS12530	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
VS_RS12570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VS_RS12590	COG3091	SprT-like family
VS_RS12595	COG2356	endonuclease I
VS_RS12605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VS_RS12610	COG0189	ligase activity
VS_RS12615	COG1678	Uncharacterized ACR, COG1678
VS_RS12620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VS_RS12635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VS_RS12640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VS_RS12645	COG0762	integral membrane protein
VS_RS12660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VS_RS12665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VS_RS12670	COG2066	Belongs to the glutaminase family
VS_RS12685	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VS_RS12690	COG0741	lytic transglycosylase activity
VS_RS12730	COG0840	transmembrane signaling receptor activity
VS_RS12795	COG3437	response regulator, receiver
VS_RS12815	COG0795	lipopolysaccharide-transporting ATPase activity
VS_RS12820	COG0795	lipopolysaccharide-transporting ATPase activity
VS_RS12830	COG2927	DNA polymerase III (CHI subunit)
VS_RS12835	COG0525	valine-tRNA ligase activity
VS_RS12845	COG0456	acetyltransferase
VS_RS12880	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VS_RS12885	COG0251	oxidation-reduction process
VS_RS12890	COG0204	Acyl-transferase
VS_RS12895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VS_RS12900	COG5007	Belongs to the BolA IbaG family
VS_RS12910	COG2854	intermembrane phospholipid transfer
VS_RS12915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VS_RS12920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VS_RS12925	COG1127	ABC transporter
VS_RS12935	COG0517	IMP dehydrogenase activity
VS_RS12935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VS_RS12940	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VS_RS12950	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VS_RS12955	COG1137	ATPase activity
VS_RS12965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VS_RS12970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS12975	COG1660	Displays ATPase and GTPase activities
VS_RS12980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS12985	COG2239	Acts as a magnesium transporter
VS_RS12990	COG0312	modulator of DNA gyrase
VS_RS12995	COG3028	Belongs to the UPF0307 family
VS_RS13000	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VS_RS13005	COG1178	ABC-type Fe3 transport system permease component
VS_RS13015	COG0163	prenyltransferase activity
VS_RS13020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VS_RS13025	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VS_RS13035	COG2105	PFAM AIG2 family protein
VS_RS13040	COG2911	Protein conserved in bacteria
VS_RS13045	COG0729	surface antigen
VS_RS13050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VS_RS13055	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VS_RS13085	COG0529	Catalyzes the synthesis of activated sulfate
VS_RS13090	COG0471	metal ion transport
VS_RS13090	COG3273	potassium ion transport
VS_RS13095	COG2895	sulfate adenylyltransferase (ATP) activity
VS_RS13100	COG0175	sulfate reduction
VS_RS13150	COG2153	protein acetylation
VS_RS13160	COG3061	Opacity-associated protein A
VS_RS13160	COG3266	domain, Protein
VS_RS13165	COG0545	Peptidyl-prolyl cis-trans isomerase
VS_RS13175	COG0203	ribosomal protein L17
VS_RS13180	COG0202	RNA polymerase activity
VS_RS13185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VS_RS13190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VS_RS13195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VS_RS13200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VS_RS13205	COG0201	protein transport
VS_RS13210	COG0200	Binds to the 23S rRNA
VS_RS13215	COG1841	ribosomal large subunit assembly
VS_RS13220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VS_RS13225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VS_RS13230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VS_RS13235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VS_RS13240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VS_RS13245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VS_RS13250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VS_RS13260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VS_RS13270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VS_RS13275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VS_RS13285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VS_RS13290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VS_RS13295	COG0089	rRNA binding
VS_RS13300	COG0088	Forms part of the polypeptide exit tunnel
VS_RS13305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VS_RS13320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VS_RS13325	COG0049	tRNA binding
VS_RS13330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VS_RS13340	COG2923	Belongs to the DsrF TusC family
VS_RS13345	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VS_RS13350	COG2964	Protein conserved in bacteria
VS_RS13355	COG0545	Peptidyl-prolyl cis-trans isomerase
VS_RS13365	COG2900	Belongs to the SlyX family
VS_RS13370	COG1446	asparaginase
VS_RS13375	COG1047	Peptidyl-prolyl cis-trans
VS_RS13395	COG0488	(ABC) transporter
VS_RS13405	COG0429	hydrolase of the alpha beta-hydrolase fold
VS_RS13410	COG3089	Belongs to the UPF0270 family
VS_RS13415	COG3954	Phosphoribulokinase
VS_RS13420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VS_RS13440	COG1012	belongs to the aldehyde dehydrogenase family
VS_RS13450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VS_RS13455	COG0512	Glutamine amidotransferase of anthranilate synthase
VS_RS13470	COG0180	Tryptophanyl-tRNA synthetase
VS_RS13475	COG0546	phosphoglycolate phosphatase activity
VS_RS13480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VS_RS13485	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VS_RS13495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VS_RS13530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VS_RS13540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VS_RS13540	COG0678	peroxiredoxin activity
VS_RS13545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VS_RS13550	COG0251	oxidation-reduction process
VS_RS13560	COG0165	Argininosuccinate lyase
VS_RS13560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VS_RS13575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VS_RS13580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VS_RS13585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VS_RS13595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VS_RS13600	COG0527	aspartate kinase activity
VS_RS13600	COG0460	homoserine dehydrogenase
VS_RS13605	COG0626	cystathionine gamma-synthase activity
VS_RS13610	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VS_RS13615	COG0281	malic enzyme
VS_RS13620	COG0254	rRNA binding
VS_RS13625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VS_RS13630	COG1609	Transcriptional regulator
VS_RS13640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VS_RS13645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VS_RS13650	COG1575	Belongs to the MenA family. Type 1 subfamily
VS_RS13655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VS_RS13660	COG3074	FtsZ-dependent cytokinesis
VS_RS13665	COG1494	fructose-1,6-bisphosphatase
VS_RS13680	COG3152	Membrane
VS_RS13700	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VS_RS13710	COG0745	RESPONSE REGULATOR receiver
VS_RS13715	COG2205	protein histidine kinase activity
VS_RS13725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VS_RS13735	COG1027	Aspartate ammonia-lyase
VS_RS13740	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VS_RS13745	COG1288	antiporter activity
VS_RS13765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VS_RS13770	COG0540	Belongs to the ATCase OTCase family
VS_RS13775	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VS_RS13780	COG1438	arginine binding
VS_RS13785	COG4232	protein-disulfide reductase activity
VS_RS13795	COG3263	regulation of cellular component size
VS_RS13805	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_RS13820	COG2198	Histidine kinase
VS_RS13820	COG2205	protein histidine kinase activity
VS_RS13820	COG0784	Response regulator, receiver
VS_RS13825	COG2814	Major facilitator Superfamily
VS_RS13840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VS_RS13845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VS_RS13850	COG0511	ligase activity, forming carbon-carbon bonds
VS_RS13855	COG0439	Biotin carboxylase
VS_RS13860	COG2264	protein methyltransferase activity
VS_RS13865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VS_RS13870	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VS_RS13875	COG2199	diguanylate cyclase activity
VS_RS13880	COG0789	Transcriptional regulator
VS_RS13885	COG0138	bifunctional purine biosynthesis protein purh
VS_RS13890	COG0151	Belongs to the GarS family
VS_RS13905	COG1253	flavin adenine dinucleotide binding
VS_RS13910	COG3068	Protein conserved in bacteria
VS_RS13920	COG1573	uracil-dna glycosylase
VS_RS13930	COG2816	NAD+ diphosphatase activity
VS_RS13935	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VS_RS13950	COG0222	ribosome binding
VS_RS13955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VS_RS13960	COG0081	regulation of translation
VS_RS13970	COG0250	Participates in transcription elongation, termination and antitermination
VS_RS14005	COG1072	(Pantothenic acid kinase))
VS_RS14015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VS_RS14025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VS_RS14070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VS_RS14080	COG4206	TonB-dependent receptor
VS_RS14085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VS_RS14100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VS_RS14105	COG0534	Mate efflux family protein
VS_RS14110	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VS_RS14115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VS_RS14120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VS_RS14125	COG2937	Belongs to the GPAT DAPAT family
VS_RS14140	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VS_RS14145	COG3161	chorismate lyase activity
VS_RS14150	COG1580	Controls the rotational direction of flagella during chemotaxis
VS_RS14155	COG0705	Rhomboid family
VS_RS14160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VS_RS14170	COG2177	Part of the ABC transporter FtsEX involved in
VS_RS14175	COG2884	Cell division ATP-binding protein ftsE
VS_RS14180	COG0552	protein localization to endoplasmic reticulum
VS_RS14180	COG0552	protein localization to endoplasmic reticulum
VS_RS14185	COG0742	ribosomal rna small subunit methyltransferase
VS_RS14195	COG2095	MarC family integral membrane protein
VS_RS14235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VS_RS14240	COG0640	Transcriptional regulator
VS_RS14245	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VS_RS14250	COG1280	lysine exporter protein (LysE YggA)
VS_RS14255	COG2267	carboxylic ester hydrolase activity
VS_RS14260	COG0561	phosphatase activity
VS_RS14275	COG3148	PFAM DTW domain containing protein
VS_RS14280	COG2200	EAL domain
VS_RS14280	COG2199	diguanylate cyclase activity
VS_RS14280	COG3287	FIST C domain
VS_RS14285	COG3287	FIST C domain
VS_RS14285	COG2200	EAL domain
VS_RS14285	COG2199	diguanylate cyclase activity
VS_RS14290	COG1011	Hydrolase
VS_RS14295	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VS_RS14305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VS_RS14310	COG0019	diaminopimelate decarboxylase activity
VS_RS14320	COG1965	Belongs to the frataxin family
VS_RS14325	COG3072	Adenylate cyclase
VS_RS14330	COG0181	hydroxymethylbilane synthase activity
VS_RS14335	COG1587	Uroporphyrinogen-III synthase
VS_RS14340	COG2959	enzyme of heme biosynthesis
VS_RS14345	COG3071	HemY protein
VS_RS14380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VS_RS14395	COG3118	belongs to the thioredoxin family
VS_RS14400	COG0513	Belongs to the DEAD box helicase family
VS_RS14405	COG0248	Ppx GppA phosphatase
VS_RS14410	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VS_RS14420	COG0514	ATP-dependent DNA helicase (RecQ)
VS_RS14425	COG2962	Rard protein
VS_RS14435	COG1280	lysine exporter protein (LysE YggA)
VS_RS14440	COG0405	Gamma-glutamyltransferase
VS_RS14450	COG0210	DNA helicase
VS_RS14460	COG3220	belongs to the UPF0276 family
VS_RS14490	COG0006	proline dipeptidase activity
VS_RS14490	COG0006	proline dipeptidase activity
VS_RS14500	COG2022	thiamine diphosphate biosynthetic process
VS_RS14505	COG2104	thiamine diphosphate biosynthetic process
VS_RS14510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VS_RS14515	COG0352	thiamine-phosphate diphosphorylase activity
VS_RS14520	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VS_RS14530	COG2132	Multicopper oxidase
VS_RS14575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VS_RS14585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VS_RS14590	COG0408	coproporphyrinogen oxidase activity
VS_RS14595	COG0009	L-threonylcarbamoyladenylate synthase
VS_RS14600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VS_RS14605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VS_RS14610	COG0551	DNA topoisomerase type I activity
VS_RS14615	COG2922	Belongs to the Smg family
VS_RS14620	COG0758	DNA mediated transformation
VS_RS14635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VS_RS14640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VS_RS14640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VS_RS14645	COG0569	domain protein
VS_RS14650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VS_RS14660	COG1272	protein, Hemolysin III
VS_RS14665	COG4326	sporulation control protein
VS_RS14670	COG3084	Protein conserved in bacteria
VS_RS14680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VS_RS14685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VS_RS14695	COG0606	chelatase, subunit chli
VS_RS14705	COG3978	acetolactate synthase activity
VS_RS14710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VS_RS14715	COG0129	dihydroxy-acid dehydratase activity
VS_RS14725	COG0583	DNA-binding transcription factor activity
VS_RS14730	COG2814	Major facilitator Superfamily
VS_RS14740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VS_RS14745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VS_RS14750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VS_RS14755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VS_RS14760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VS_RS14765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VS_RS14780	COG3312	ion transport
VS_RS14785	COG1475	DNA binding
VS_RS14790	COG1192	Involved in chromosome partitioning
VS_RS14795	COG0357	Ribosomal RNA small subunit methyltransferase G
VS_RS14800	COG0445	tRNA wobble uridine modification
VS_RS14920	COG0751	glycine-tRNA ligase activity
VS_RS14955	COG1250	3-hydroxyacyl-CoA dehydrogenase
VS_RS14955	COG1024	Enoyl-CoA hydratase
VS_RS15050	COG4608	Belongs to the ABC transporter superfamily
VS_RS15290	COG3852	Histidine kinase
VS_RS15330	COG1295	ribonuclease BN
VS_RS15450	COG2183	response to ionizing radiation
VS_RS15545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VS_RS15825	COG0840	transmembrane signaling receptor activity
VS_RS16235	COG3164	Protein of unknown function
VS_RS16315	COG0039	L-malate dehydrogenase activity
VS_RS16355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VS_RS16550	COG3409	Peptidoglycan-binding domain 1 protein
VS_RS16550	COG3267	Type II secretory pathway component ExeA
VS_RS16585	COG3025	triphosphatase activity
VS_RS16610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VS_RS16775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VS_RS16805	COG0653	protein targeting
VS_RS16845	COG0730	response to heat
VS_RS16915	COG0067	glutamate synthase
VS_RS16915	COG0070	glutamate synthase
VS_RS16915	COG0069	glutamate synthase activity
VS_RS16940	COG2198	Histidine kinase
VS_RS16940	COG5002	protein histidine kinase activity
VS_RS16940	COG0784	Response regulator, receiver
VS_RS17170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VS_RS17415	COG0343	queuine tRNA-ribosyltransferase activity
VS_RS17525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VS_RS17545	COG0517	IMP dehydrogenase activity
VS_RS17545	COG0516	GMP reductase activity
VS_RS17640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VS_RS17775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VS_RS17935	COG1477	protein flavinylation
VS_RS18025	COG0495	leucyl-tRNA aminoacylation
VS_RS18140	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VS_RS18865	COG1902	pentaerythritol trinitrate reductase activity
VS_RS18865	COG0446	pyridine nucleotide-disulphide oxidoreductase
VS_RS19225	COG0572	uridine kinase
VS_RS19350	COG0733	neurotransmitter:sodium symporter activity
VS_RS19450	COG2719	SpoVR family
VS_RS19530	COG1770	oligopeptidase
VS_RS19825	COG1032	radical SAM domain protein
VS_RS19995	COG1280	lysine exporter protein (LysE YggA)
VS_RS20255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VS_RS20475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_RS20775	COG5002	protein histidine kinase activity
VS_RS20775	COG2205	protein histidine kinase activity
VS_RS20775	COG0784	Response regulator, receiver
VS_RS21075	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
VS_RS21270	COG4597	amino acid ABC transporter
VS_RS21330	COG1956	GAF domain-containing protein
VS_RS21350	COG0308	aminopeptidase N
VS_RS21375	COG2902	Dehydrogenase
VS_RS21405	COG0116	Belongs to the methyltransferase superfamily
VS_RS21405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VS_RS21440	COG1067	ATP-dependent peptidase activity
VS_RS21585	COG0589	response to stress
VS_RS21670	COG0243	molybdopterin cofactor binding
VS_RS21715	COG3852	Histidine kinase
VS_RS21810	COG0534	Mate efflux family protein
VS_RS21930	COG1401	restriction endodeoxyribonuclease activity
VS_RS21985	COG0469	pyruvate kinase activity