locus-tag	class	description
GPY16_RS00010	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPY16_RS00015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY16_RS00020	COG1739	Uncharacterized protein family UPF0029
GPY16_RS00030	COG0183	Belongs to the thiolase family
GPY16_RS00035	COG0604	alcohol dehydrogenase
GPY16_RS00060	COG2119	membrane
GPY16_RS00070	COG0751	glycine-tRNA ligase activity
GPY16_RS00080	COG3977	Valine--pyruvate aminotransferase
GPY16_RS00090	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY16_RS00095	COG0187	DNA topoisomerase II activity
GPY16_RS00105	COG0592	DNA-directed DNA polymerase activity
GPY16_RS00125	COG1126	abc transporter atp-binding protein
GPY16_RS00140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY16_RS00145	COG0706	membrane insertase activity
GPY16_RS00155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY16_RS00160	COG0445	tRNA wobble uridine modification
GPY16_RS00170	COG1192	Involved in chromosome partitioning
GPY16_RS00175	COG1475	DNA binding
GPY16_RS00180	COG3312	ion transport
GPY16_RS00230	COG0765	amino acid transport
GPY16_RS00240	COG2814	Major facilitator Superfamily
GPY16_RS00245	COG0583	DNA-binding transcription factor activity
GPY16_RS00255	COG0129	dihydroxy-acid dehydratase activity
GPY16_RS00260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY16_RS00265	COG3978	acetolactate synthase activity
GPY16_RS00275	COG0606	chelatase, subunit chli
GPY16_RS00290	COG2856	Zn peptidase
GPY16_RS00305	COG0204	Acyl-transferase
GPY16_RS00310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY16_RS00315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY16_RS00325	COG3084	Protein conserved in bacteria
GPY16_RS00330	COG4326	sporulation control protein
GPY16_RS00335	COG1272	protein, Hemolysin III
GPY16_RS00340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY16_RS00345	COG0569	domain protein
GPY16_RS00350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY16_RS00350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY16_RS00355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY16_RS00360	COG0242	peptide deformylase activity
GPY16_RS00370	COG0758	DNA mediated transformation
GPY16_RS00380	COG0551	DNA topoisomerase type I activity
GPY16_RS00400	COG0408	coproporphyrinogen oxidase activity
GPY16_RS00405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY16_RS00415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY16_RS00450	COG0583	DNA-binding transcription factor activity
GPY16_RS00460	COG2960	long-chain fatty acid transporting porin activity
GPY16_RS00465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY16_RS00470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY16_RS00475	COG1309	transcriptional regulator
GPY16_RS00515	COG4172	Belongs to the ABC transporter superfamily
GPY16_RS00520	COG4166	transmembrane transport
GPY16_RS00530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY16_RS00565	COG2815	serine threonine protein kinase
GPY16_RS00565	COG0515	serine threonine protein kinase
GPY16_RS00580	COG1609	Transcriptional regulator
GPY16_RS00590	COG3265	gluconokinase activity
GPY16_RS00595	COG2610	gluconate transmembrane transporter activity
GPY16_RS00600	COG0800	Aldolase
GPY16_RS00615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY16_RS00620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY16_RS00630	COG1522	sequence-specific DNA binding
GPY16_RS00635	COG5002	protein histidine kinase activity
GPY16_RS00635	COG5001	Diguanylate cyclase
GPY16_RS00640	COG0742	ribosomal rna small subunit methyltransferase
GPY16_RS00655	COG0589	response to stress
GPY16_RS00660	COG1528	Iron-storage protein
GPY16_RS00670	COG2081	HI0933 family
GPY16_RS00680	COG2959	enzyme of heme biosynthesis
GPY16_RS00695	COG3072	Adenylate cyclase
GPY16_RS00710	COG0019	diaminopimelate decarboxylase activity
GPY16_RS00730	COG1011	Hydrolase
GPY16_RS00735	COG2200	EAL domain
GPY16_RS00735	COG2199	diguanylate cyclase activity
GPY16_RS00735	COG3287	FIST C domain
GPY16_RS00755	COG0561	phosphatase activity
GPY16_RS00760	COG2267	carboxylic ester hydrolase activity
GPY16_RS00765	COG1280	lysine exporter protein (LysE YggA)
GPY16_RS00770	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY16_RS00775	COG0640	Transcriptional regulator
GPY16_RS00780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY16_RS00820	COG2095	MarC family integral membrane protein
GPY16_RS00830	COG0742	ribosomal rna small subunit methyltransferase
GPY16_RS00835	COG0552	protein localization to endoplasmic reticulum
GPY16_RS00840	COG2884	Cell division ATP-binding protein ftsE
GPY16_RS00845	COG2177	Part of the ABC transporter FtsEX involved in
GPY16_RS00860	COG0705	Rhomboid family
GPY16_RS00865	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY16_RS00870	COG3161	chorismate lyase activity
GPY16_RS00880	COG2937	Belongs to the GPAT DAPAT family
GPY16_RS00935	COG0328	RNA-DNA hybrid ribonuclease activity
GPY16_RS00945	COG4974	Belongs to the 'phage' integrase family
GPY16_RS00950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY16_RS00955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY16_RS00990	COG2003	Belongs to the UPF0758 family
GPY16_RS01035	COG4206	TonB-dependent receptor
GPY16_RS01115	COG3335	DDE superfamily endonuclease
GPY16_RS01120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY16_RS01130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY16_RS01170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY16_RS01210	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY16_RS01235	COG1573	uracil-dna glycosylase
GPY16_RS01240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY16_RS01245	COG3068	Protein conserved in bacteria
GPY16_RS01250	COG1253	flavin adenine dinucleotide binding
GPY16_RS01275	COG0789	Transcriptional regulator
GPY16_RS01280	COG0840	transmembrane signaling receptor activity
GPY16_RS01305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY16_RS01315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY16_RS01335	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY16_RS01385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY16_RS01395	COG2264	protein methyltransferase activity
GPY16_RS01400	COG0439	Biotin carboxylase
GPY16_RS01405	COG0511	ligase activity, forming carbon-carbon bonds
GPY16_RS01415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY16_RS01430	COG2814	Major facilitator Superfamily
GPY16_RS01435	COG2205	protein histidine kinase activity
GPY16_RS01435	COG0784	Response regulator, receiver
GPY16_RS01435	COG2198	Histidine kinase
GPY16_RS01450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY16_RS01460	COG2095	MarC family integral membrane protein
GPY16_RS01470	COG4232	protein-disulfide reductase activity
GPY16_RS01475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY16_RS01480	COG1027	Aspartate ammonia-lyase
GPY16_RS01490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY16_RS01495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GPY16_RS01500	COG2205	protein histidine kinase activity
GPY16_RS01505	COG0745	RESPONSE REGULATOR receiver
GPY16_RS01510	COG3678	ATP-independent chaperone mediated protein folding
GPY16_RS01525	COG0534	Mate efflux family protein
GPY16_RS01545	COG1285	pathogenesis
GPY16_RS01550	COG1509	lysine 2,3-aminomutase activity
GPY16_RS01570	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY16_RS01580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY16_RS01585	COG1053	succinate dehydrogenase
GPY16_RS01610	COG4942	peptidase
GPY16_RS01615	COG1045	serine acetyltransferase
GPY16_RS01630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY16_RS01640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY16_RS01650	COG0471	metal ion transport
GPY16_RS01725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY16_RS01730	COG0802	atpase or kinase
GPY16_RS01735	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPY16_RS01740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY16_RS01755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY16_RS01760	COG0330	HflC and HflK could
GPY16_RS01765	COG0330	HflC and HflK could
GPY16_RS01770	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY16_RS01775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY16_RS01780	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY16_RS01795	COG0402	S-adenosylhomocysteine deaminase activity
GPY16_RS01800	COG0557	exoribonuclease II activity
GPY16_RS01835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY16_RS01855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY16_RS01860	COG3954	Phosphoribulokinase
GPY16_RS01870	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY16_RS01880	COG0488	(ABC) transporter
GPY16_RS01885	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY16_RS01900	COG1047	Peptidyl-prolyl cis-trans
GPY16_RS01920	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY16_RS01925	COG2964	Protein conserved in bacteria
GPY16_RS01930	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY16_RS01955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY16_RS01965	COG2906	2 iron, 2 sulfur cluster binding
GPY16_RS01975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY16_RS02005	COG1494	fructose-1,6-bisphosphatase
GPY16_RS02020	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY16_RS02040	COG1609	Transcriptional regulator
GPY16_RS02045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY16_RS02055	COG0281	malic enzyme
GPY16_RS02065	COG0626	cystathionine gamma-synthase activity
GPY16_RS02070	COG0527	aspartate kinase activity
GPY16_RS02070	COG0460	homoserine dehydrogenase
GPY16_RS02075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY16_RS02085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY16_RS02090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY16_RS02095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY16_RS02125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY16_RS02170	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY16_RS02175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY16_RS02205	COG0305	Participates in initiation and elongation during chromosome replication
GPY16_RS02210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY16_RS02220	COG0432	Pfam Uncharacterised protein family UPF0047
GPY16_RS02235	COG0735	belongs to the Fur family
GPY16_RS02265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY16_RS02350	COG0745	RESPONSE REGULATOR receiver
GPY16_RS02350	COG3706	GGDEF domain
GPY16_RS02360	COG0646	methionine synthase
GPY16_RS02360	COG1410	methionine synthase
GPY16_RS02365	COG0527	aspartate kinase activity
GPY16_RS02370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY16_RS02400	COG2200	EAL domain
GPY16_RS02400	COG2199	diguanylate cyclase activity
GPY16_RS02425	COG3267	Type II secretory pathway component ExeA
GPY16_RS02425	COG3409	Peptidoglycan-binding domain 1 protein
GPY16_RS02435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY16_RS02440	COG1459	type II secretion system
GPY16_RS02485	COG1077	Cell shape determining protein MreB Mrl
GPY16_RS02490	COG1792	Involved in formation and maintenance of cell shape
GPY16_RS02495	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY16_RS02505	COG1530	ribonuclease E activity
GPY16_RS02510	COG3164	Protein of unknown function
GPY16_RS02515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY16_RS02520	COG0312	modulator of DNA gyrase
GPY16_RS02525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY16_RS02530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY16_RS02540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY16_RS02545	COG0251	oxidation-reduction process
GPY16_RS02580	COG0456	acetyltransferase
GPY16_RS02590	COG4269	membrane
GPY16_RS02605	COG2927	DNA polymerase III (CHI subunit)
GPY16_RS02615	COG0795	lipopolysaccharide-transporting ATPase activity
GPY16_RS02620	COG0795	lipopolysaccharide-transporting ATPase activity
GPY16_RS02635	COG0726	polysaccharide deacetylase
GPY16_RS02640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY16_RS02650	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY16_RS02655	COG1486	melibiose metabolic process
GPY16_RS02660	COG3394	polysaccharide catabolic process
GPY16_RS02665	COG1609	Transcriptional regulator
GPY16_RS02760	COG0840	transmembrane signaling receptor activity
GPY16_RS02780	COG0741	lytic transglycosylase activity
GPY16_RS02805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY16_RS02825	COG0762	integral membrane protein
GPY16_RS02830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY16_RS02835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY16_RS02865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY16_RS02875	COG2356	endonuclease I
GPY16_RS02895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY16_RS02905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY16_RS02915	COG0191	fructose-bisphosphate aldolase activity
GPY16_RS02920	COG0668	transmembrane transport
GPY16_RS02925	COG1279	arginine transmembrane transporter activity
GPY16_RS02940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY16_RS02950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY16_RS02960	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY16_RS02965	COG3079	Belongs to the UPF0149 family
GPY16_RS02970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY16_RS02975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY16_RS02990	COG0354	folic acid binding
GPY16_RS03005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY16_RS03010	COG1595	DNA-templated transcription, initiation
GPY16_RS03025	COG3086	response to oxidative stress
GPY16_RS03035	COG0681	Belongs to the peptidase S26 family
GPY16_RS03050	COG1381	Involved in DNA repair and RecF pathway recombination
GPY16_RS03060	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY16_RS03080	COG4999	Histidine kinase
GPY16_RS03080	COG3850	Histidine kinase
GPY16_RS03080	COG3437	response regulator, receiver
GPY16_RS03080	COG2205	protein histidine kinase activity
GPY16_RS03085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY16_RS03090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY16_RS03095	COG3956	TIGRFAM MazG family protein
GPY16_RS03120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY16_RS03125	COG0585	pseudouridine synthase activity
GPY16_RS03140	COG1388	LysM domain
GPY16_RS03140	COG4942	peptidase
GPY16_RS03145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY16_RS03150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY16_RS03170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY16_RS03175	COG0527	aspartate kinase activity
GPY16_RS03230	COG5016	pyruvate
GPY16_RS03230	COG0511	ligase activity, forming carbon-carbon bonds
GPY16_RS03235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY16_RS03245	COG1238	metal cluster binding
GPY16_RS03250	COG0612	Peptidase, M16
GPY16_RS03270	COG4536	flavin adenine dinucleotide binding
GPY16_RS03275	COG4137	Cytochrome C assembly protein
GPY16_RS03280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY16_RS03305	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY16_RS03315	COG0237	dephospho-CoA kinase activity
GPY16_RS03325	COG1459	type II secretion system
GPY16_RS03330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY16_RS03345	COG3023	N-Acetylmuramoyl-L-alanine amidase
GPY16_RS03350	COG2186	Transcriptional regulator
GPY16_RS03355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY16_RS03360	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY16_RS03365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY16_RS03380	COG0288	reversible hydration of carbon dioxide
GPY16_RS03385	COG0659	secondary active sulfate transmembrane transporter activity
GPY16_RS03390	COG1131	(ABC) transporter
GPY16_RS03395	COG0842	Transport permease protein
GPY16_RS03410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY16_RS03425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY16_RS03430	COG1489	DNA binding
GPY16_RS03435	COG1643	Atp-dependent helicase
GPY16_RS03440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY16_RS03445	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY16_RS03450	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY16_RS03455	COG1929	Belongs to the glycerate kinase type-1 family
GPY16_RS03460	COG2610	gluconate transmembrane transporter activity
GPY16_RS03465	COG3835	regulator
GPY16_RS03475	COG0347	Belongs to the P(II) protein family
GPY16_RS03480	COG0004	ammonium transporteR
GPY16_RS03485	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY16_RS03495	COG3842	ATPase activity
GPY16_RS03500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY16_RS03515	COG2971	BadF BadG BcrA BcrD
GPY16_RS03525	COG4608	Belongs to the ABC transporter superfamily
GPY16_RS03530	COG0444	Belongs to the ABC transporter superfamily
GPY16_RS03535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY16_RS03540	COG0601	transmembrane transport
GPY16_RS03545	COG0747	negative chemotaxis
GPY16_RS03550	COG2205	protein histidine kinase activity
GPY16_RS03550	COG0784	Response regulator, receiver
GPY16_RS03560	COG0628	permease
GPY16_RS03585	COG0739	heme binding
GPY16_RS03595	COG2832	Protein of unknown function (DUF454)
GPY16_RS03600	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY16_RS03615	COG1534	Rna-binding protein
GPY16_RS03625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY16_RS03630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY16_RS03640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY16_RS03660	COG0195	Participates in both transcription termination and antitermination
GPY16_RS03700	COG4785	May be involved in cell division
GPY16_RS03710	COG0534	Mate efflux family protein
GPY16_RS03735	COG3153	acetyltransferase
GPY16_RS03745	COG0456	acetyltransferase
GPY16_RS03755	COG3706	GGDEF domain
GPY16_RS03770	COG0084	hydrolase, TatD family'
GPY16_RS03775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY16_RS03780	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY16_RS03805	COG0560	Phosphoserine phosphatase
GPY16_RS03820	COG5002	protein histidine kinase activity
GPY16_RS03820	COG5001	Diguanylate cyclase
GPY16_RS03820	COG3447	MASE1 domain protein
GPY16_RS03835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY16_RS03840	COG1022	Amp-dependent synthetase and ligase
GPY16_RS03875	COG4964	Belongs to the GSP D family
GPY16_RS03925	COG2059	Chromate
GPY16_RS03930	COG0583	DNA-binding transcription factor activity
GPY16_RS03940	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GPY16_RS03940	COG3408	Glycogen debranching enzyme
GPY16_RS03945	COG0531	amino acid
GPY16_RS03950	COG0531	amino acid
GPY16_RS03955	COG2731	YhcH YjgK YiaL family protein
GPY16_RS03960	COG3250	beta-galactosidase activity
GPY16_RS03970	COG1609	Transcriptional regulator
GPY16_RS03975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY16_RS03990	COG2017	converts alpha-aldose to the beta-anomer
GPY16_RS03995	COG0840	transmembrane signaling receptor activity
GPY16_RS04005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY16_RS04020	COG0569	domain protein
GPY16_RS04020	COG0189	ligase activity
GPY16_RS04035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY16_RS04040	COG1349	DNA-binding transcription factor activity
GPY16_RS04050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY16_RS04055	COG2171	N-acyltransferase activity
GPY16_RS04060	COG3141	response to X-ray
GPY16_RS04075	COG3083	sulfuric ester hydrolase activity
GPY16_RS04080	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY16_RS04085	COG1074	ATP-dependent DNA helicase activity
GPY16_RS04090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY16_RS04110	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY16_RS04115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY16_RS04120	COG2166	iron-sulfur cluster assembly
GPY16_RS04125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY16_RS04130	COG0693	protein deglycase activity
GPY16_RS04135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY16_RS04150	COG1595	DNA-templated transcription, initiation
GPY16_RS04160	COG2211	Major facilitator Superfamily
GPY16_RS04180	COG0271	Belongs to the BolA IbaG family
GPY16_RS04215	COG1477	protein flavinylation
GPY16_RS04225	COG0745	RESPONSE REGULATOR receiver
GPY16_RS04225	COG3706	GGDEF domain
GPY16_RS04235	COG0514	ATP-dependent DNA helicase (RecQ)
GPY16_RS04250	COG0733	neurotransmitter:sodium symporter activity
GPY16_RS04275	COG1720	tRNA m6t6A37 methyltransferase activity
GPY16_RS04280	COG0254	rRNA binding
GPY16_RS04290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY16_RS04295	COG1671	Belongs to the UPF0178 family
GPY16_RS04325	COG3098	single-species biofilm formation
GPY16_RS04340	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY16_RS04345	COG0024	Methionine aminopeptidase
GPY16_RS04365	COG0233	cytoplasmic translational termination
GPY16_RS04375	COG0575	Belongs to the CDS family
GPY16_RS04385	COG0750	zinc metalloprotease
GPY16_RS04390	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY16_RS04395	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY16_RS04425	COG0587	DNA-directed DNA polymerase activity
GPY16_RS04445	COG0347	Belongs to the P(II) protein family
GPY16_RS04450	COG3021	interspecies interaction between organisms
GPY16_RS04460	COG0741	lytic transglycosylase activity
GPY16_RS04460	COG1388	LysM domain
GPY16_RS04465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY16_RS04470	COG2226	methyltransferase
GPY16_RS04480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY16_RS04490	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY16_RS04530	COG1960	acyl-CoA dehydrogenase activity
GPY16_RS04540	COG0121	glutamine amidotransferase
GPY16_RS04545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY16_RS04555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY16_RS04560	COG2233	PERMEase
GPY16_RS04580	COG1393	Belongs to the ArsC family
GPY16_RS04585	COG4783	chaperone-mediated protein folding
GPY16_RS04600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY16_RS04605	COG2716	regulation of RNA biosynthetic process
GPY16_RS04610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY16_RS04635	COG1393	Belongs to the ArsC family
GPY16_RS04660	COG2837	iron assimilation
GPY16_RS04665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY16_RS04670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY16_RS04675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY16_RS04680	COG1334	flagellar protein FlaG
GPY16_RS04685	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY16_RS04695	COG1516	flagellar protein fliS
GPY16_RS04700	COG2204	response regulator
GPY16_RS04705	COG4191	Histidine kinase
GPY16_RS04710	COG2204	response regulator
GPY16_RS04715	COG1677	Flagellar hook-basal body complex protein FliE
GPY16_RS04725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY16_RS04775	COG1987	bacterial-type flagellum assembly
GPY16_RS04780	COG1684	flagellar biosynthetic protein fliR
GPY16_RS04800	COG0455	bacterial-type flagellum organization
GPY16_RS04815	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY16_RS04820	COG2198	Histidine kinase
GPY16_RS04820	COG0643	Histidine kinase
GPY16_RS04830	COG1192	Involved in chromosome partitioning
GPY16_RS04840	COG0835	chemotaxis
GPY16_RS04850	COG4133	protoheme IX ABC transporter activity
GPY16_RS04855	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY16_RS04860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY16_RS04865	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY16_RS04875	COG1138	Cytochrome C-type biogenesis protein
GPY16_RS04880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY16_RS04885	COG3088	subunit of a heme lyase
GPY16_RS04885	COG4235	cytochrome complex assembly
GPY16_RS04895	COG2853	Lipoprotein
GPY16_RS04900	COG2067	long-chain fatty acid transport protein
GPY16_RS04905	COG2067	long-chain fatty acid transport protein
GPY16_RS04930	COG1025	Belongs to the peptidase M16 family
GPY16_RS04935	COG2062	phosphohistidine phosphatase, SixA
GPY16_RS04940	COG2840	Smr protein MutS2
GPY16_RS04945	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY16_RS04955	COG2860	membrane
GPY16_RS04975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY16_RS04985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY16_RS05005	COG0285	dihydrofolate synthase activity
GPY16_RS05010	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY16_RS05015	COG1286	toxin biosynthetic process
GPY16_RS05020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY16_RS05025	COG0583	DNA-binding transcription factor activity
GPY16_RS05030	COG0745	RESPONSE REGULATOR receiver
GPY16_RS05040	COG2832	Protein of unknown function (DUF454)
GPY16_RS05055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY16_RS05075	COG2205	protein histidine kinase activity
GPY16_RS05080	COG0745	RESPONSE REGULATOR receiver
GPY16_RS05095	COG2983	Belongs to the UPF0260 family
GPY16_RS05105	COG0346	lactoylglutathione lyase activity
GPY16_RS05115	COG1785	Belongs to the alkaline phosphatase family
GPY16_RS05130	COG2226	methyltransferase
GPY16_RS05145	COG2239	Acts as a magnesium transporter
GPY16_RS05150	COG2203	Gaf domain
GPY16_RS05150	COG2199	diguanylate cyclase activity
GPY16_RS05165	COG3710	Transcriptional regulator
GPY16_RS05170	COG0531	amino acid
GPY16_RS05175	COG1982	Orn Lys Arg decarboxylase major
GPY16_RS05180	COG2199	diguanylate cyclase activity
GPY16_RS05185	COG4109	DRTGG domain
GPY16_RS05190	COG2217	Heavy metal translocating P-type atpase
GPY16_RS05210	COG0537	adenosine 5'-monophosphoramidase activity
GPY16_RS05240	COG1252	NADH dehydrogenase
GPY16_RS05265	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY16_RS05275	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY16_RS05285	COG2333	competence protein COMEC
GPY16_RS05285	COG0658	competence protein
GPY16_RS05295	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY16_RS05305	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY16_RS05310	COG2199	diguanylate cyclase activity
GPY16_RS05315	COG2719	SpoVR family
GPY16_RS05320	COG2718	Belongs to the UPF0229 family
GPY16_RS05325	COG2766	serine protein kinase
GPY16_RS05340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY16_RS05355	COG1882	Formate acetyltransferase
GPY16_RS05380	COG4215	(ABC) transporter
GPY16_RS05395	COG0708	Exodeoxyribonuclease III
GPY16_RS05400	COG0840	transmembrane signaling receptor activity
GPY16_RS05410	COG3923	Primosomal replication protein n
GPY16_RS05415	COG0730	response to heat
GPY16_RS05420	COG1199	ATP-dependent helicase activity
GPY16_RS05425	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY16_RS05445	COG1278	Cold shock
GPY16_RS05455	COG0542	response to heat
GPY16_RS05460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY16_RS05465	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY16_RS05480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY16_RS05490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY16_RS05495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY16_RS05520	COG3070	regulator of competence-specific genes
GPY16_RS05535	COG0745	RESPONSE REGULATOR receiver
GPY16_RS05540	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY16_RS05545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY16_RS05550	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY16_RS05560	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY16_RS05590	COG0189	ligase activity
GPY16_RS05590	COG4067	protein conserved in archaea
GPY16_RS05600	COG4106	trans-aconitate 2-methyltransferase activity
GPY16_RS05625	COG2255	four-way junction helicase activity
GPY16_RS05630	COG1271	oxidase subunit
GPY16_RS05635	COG1294	oxidase, subunit
GPY16_RS05640	COG4890	Cyd operon protein YbgT
GPY16_RS05650	COG0824	Thioesterase
GPY16_RS05655	COG0811	peptide transport
GPY16_RS05670	COG0823	Involved in the tonB-independent uptake of proteins
GPY16_RS05675	COG2885	chlorophyll binding
GPY16_RS05680	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY16_RS05685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY16_RS05695	COG3766	membrane
GPY16_RS05705	COG0754	glutathionylspermidine amidase activity
GPY16_RS05715	COG0784	Response regulator, receiver
GPY16_RS05715	COG2205	protein histidine kinase activity
GPY16_RS05795	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPY16_RS05810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY16_RS05820	COG0840	transmembrane signaling receptor activity
GPY16_RS05825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY16_RS05830	COG0861	Integral membrane protein TerC family
GPY16_RS05845	COG2207	Transcriptional regulator
GPY16_RS05865	COG1032	radical SAM domain protein
GPY16_RS05890	COG0583	DNA-binding transcription factor activity
GPY16_RS05900	COG0857	belongs to the CobB CobQ family
GPY16_RS05900	COG0280	phosphate acetyltransferase
GPY16_RS05910	COG3092	negative regulation of chromosome organization
GPY16_RS05920	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY16_RS05930	COG0366	Alpha amylase catalytic
GPY16_RS05945	COG0653	protein targeting
GPY16_RS05955	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY16_RS05990	COG2989	Protein conserved in bacteria
GPY16_RS05995	COG3108	Peptidase M15
GPY16_RS06000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY16_RS06015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY16_RS06040	COG1846	Transcriptional regulator
GPY16_RS06045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY16_RS06050	COG0840	transmembrane signaling receptor activity
GPY16_RS06070	COG1448	Aminotransferase
GPY16_RS06075	COG2770	Histidine kinase
GPY16_RS06075	COG3437	response regulator, receiver
GPY16_RS06090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY16_RS06110	COG0720	synthase
GPY16_RS06120	COG2200	EAL domain
GPY16_RS06125	COG1760	l-serine dehydratase
GPY16_RS06130	COG0814	amino acid
GPY16_RS06135	COG0494	nUDIX hydrolase
GPY16_RS06150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY16_RS06165	COG3106	COG3106 Predicted ATPase
GPY16_RS06170	COG3768	UPF0283 membrane protein
GPY16_RS06175	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY16_RS06180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY16_RS06195	COG0471	metal ion transport
GPY16_RS06200	COG4191	Histidine kinase
GPY16_RS06200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY16_RS06210	COG3706	GGDEF domain
GPY16_RS06215	COG2199	diguanylate cyclase activity
GPY16_RS06215	COG2200	EAL domain
GPY16_RS06230	COG3300	MHYT domain
GPY16_RS06230	COG5001	Diguanylate cyclase
GPY16_RS06235	COG1328	CTP reductase activity
GPY16_RS06240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY16_RS06245	COG0583	DNA-binding transcription factor activity
GPY16_RS06260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY16_RS06265	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY16_RS06275	COG1597	lipid kinase activity
GPY16_RS06280	COG0814	amino acid
GPY16_RS06295	COG0783	Belongs to the Dps family
GPY16_RS06310	COG1132	(ABC) transporter
GPY16_RS06320	COG1115	amino acid carrier protein
GPY16_RS06335	COG1596	polysaccharide export
GPY16_RS06365	COG0438	transferase activity, transferring glycosyl groups
GPY16_RS06365	COG0297	glycogen (starch) synthase activity
GPY16_RS06420	COG0443	Heat shock 70 kDa protein
GPY16_RS06425	COG0443	Heat shock 70 kDa protein
GPY16_RS06435	COG3706	GGDEF domain
GPY16_RS06455	COG3713	MltA-interacting MipA family protein
GPY16_RS06485	COG4964	Belongs to the GSP D family
GPY16_RS06495	COG2894	cell division
GPY16_RS06535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY16_RS06545	COG1643	Atp-dependent helicase
GPY16_RS06570	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY16_RS06575	COG5380	lipid catabolic process
GPY16_RS06580	COG2814	Major facilitator Superfamily
GPY16_RS06585	COG0010	Belongs to the arginase family
GPY16_RS06650	COG3706	GGDEF domain
GPY16_RS06650	COG0745	RESPONSE REGULATOR receiver
GPY16_RS06660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY16_RS06660	COG0072	phenylalanine-tRNA ligase activity
GPY16_RS06715	COG2885	chlorophyll binding
GPY16_RS06730	COG0247	lactate metabolic process
GPY16_RS06730	COG0277	FAD linked oxidase domain protein
GPY16_RS06735	COG2020	methyltransferase activity
GPY16_RS06755	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY16_RS06765	COG1228	amidohydrolase
GPY16_RS06775	COG4326	sporulation control protein
GPY16_RS06875	COG2801	Transposase and inactivated derivatives
GPY16_RS06905	COG0456	acetyltransferase
GPY16_RS07020	COG1280	lysine exporter protein (LysE YggA)
GPY16_RS07055	COG2801	Transposase and inactivated derivatives
GPY16_RS07070	COG4628	conserved protein (DUF2132)
GPY16_RS07165	COG0346	lactoylglutathione lyase activity
GPY16_RS07175	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPY16_RS07225	COG1942	4-Oxalocrotonate Tautomerase
GPY16_RS07420	COG4628	conserved protein (DUF2132)
GPY16_RS07470	COG0534	Mate efflux family protein
GPY16_RS07475	COG0307	riboflavin synthase, alpha
GPY16_RS07495	COG3706	GGDEF domain
GPY16_RS07505	COG0791	NLP P60 protein
GPY16_RS07510	COG3290	protein histidine kinase activity
GPY16_RS07510	COG0840	transmembrane signaling receptor activity
GPY16_RS07540	COG0746	molybdenum cofactor guanylyltransferase activity
GPY16_RS07545	COG3842	ATPase activity
GPY16_RS07550	COG4662	Binding-protein-dependent transport system inner membrane component
GPY16_RS07560	COG2204	response regulator
GPY16_RS07565	COG3852	Histidine kinase
GPY16_RS07580	COG0488	(ABC) transporter
GPY16_RS07590	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY16_RS07620	COG0243	molybdopterin cofactor binding
GPY16_RS07620	COG3383	formate dehydrogenase (NAD+) activity
GPY16_RS07625	COG0437	4 iron, 4 sulfur cluster binding
GPY16_RS07650	COG0004	ammonium transporteR
GPY16_RS07655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY16_RS07660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY16_RS07665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY16_RS07670	COG1177	transmembrane transport
GPY16_RS07675	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY16_RS07690	COG2992	FlgJ-related protein
GPY16_RS07705	COG0589	response to stress
GPY16_RS07710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY16_RS07725	COG2217	Heavy metal translocating P-type atpase
GPY16_RS07735	COG2010	Cytochrome c
GPY16_RS07750	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY16_RS07785	COG3120	sequence-specific DNA binding
GPY16_RS07790	COG1067	ATP-dependent peptidase activity
GPY16_RS07810	COG0488	(ABC) transporter
GPY16_RS07820	COG0116	Belongs to the methyltransferase superfamily
GPY16_RS07820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY16_RS07835	COG2902	Dehydrogenase
GPY16_RS07845	COG0308	aminopeptidase N
GPY16_RS07865	COG1956	GAF domain-containing protein
GPY16_RS07870	COG1132	(ABC) transporter
GPY16_RS07875	COG2995	paraquat-inducible protein a
GPY16_RS07880	COG3008	intermembrane lipid transfer
GPY16_RS07890	COG2996	Protein conserved in bacteria
GPY16_RS07905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY16_RS07915	COG3706	GGDEF domain
GPY16_RS07925	COG1366	Belongs to the anti-sigma-factor antagonist family
GPY16_RS07955	COG2204	response regulator
GPY16_RS08000	COG0438	transferase activity, transferring glycosyl groups
GPY16_RS08010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY16_RS08050	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY16_RS08055	COG0363	glucosamine-6-phosphate deaminase activity
GPY16_RS08060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY16_RS08065	COG4565	transcriptional regulatory protein
GPY16_RS08070	COG3290	protein histidine kinase activity
GPY16_RS08085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY16_RS08110	COG1115	amino acid carrier protein
GPY16_RS08125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY16_RS08130	COG1960	acyl-CoA dehydrogenase activity
GPY16_RS08145	COG3384	dioxygenase
GPY16_RS08180	COG3971	2-oxopent-4-enoate hydratase activity
GPY16_RS08200	COG1846	Transcriptional regulator
GPY16_RS08260	COG0204	Acyl-transferase
GPY16_RS08265	COG0348	domain, Protein
GPY16_RS08270	COG0437	4 iron, 4 sulfur cluster binding
GPY16_RS08280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY16_RS08285	COG4597	amino acid ABC transporter
GPY16_RS08290	COG0765	amino acid transport
GPY16_RS08295	COG1126	abc transporter atp-binding protein
GPY16_RS08300	COG0670	Belongs to the BI1 family
GPY16_RS08305	COG2920	part of a sulfur-relay system
GPY16_RS08310	COG1254	Belongs to the acylphosphatase family
GPY16_RS08320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY16_RS08345	COG3706	GGDEF domain
GPY16_RS08350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY16_RS08355	COG0602	queuosine metabolic process
GPY16_RS08360	COG0561	phosphatase activity
GPY16_RS08390	COG2828	Protein conserved in bacteria
GPY16_RS08395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GPY16_RS08400	COG0372	Belongs to the citrate synthase family
GPY16_RS08405	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY16_RS08435	COG1401	restriction endodeoxyribonuclease activity
GPY16_RS08470	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GPY16_RS08560	COG2197	response regulator
GPY16_RS08575	COG0840	transmembrane signaling receptor activity
GPY16_RS08590	COG1175	transmembrane transport
GPY16_RS08595	COG0395	ABC-type sugar transport system, permease component
GPY16_RS08600	COG3842	ATPase activity
GPY16_RS08605	COG1349	DNA-binding transcription factor activity
GPY16_RS08610	COG0584	glycerophosphoryl diester phosphodiesterase
GPY16_RS08615	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY16_RS08625	COG1278	Cold shock
GPY16_RS08665	COG0625	glutathione transferase activity
GPY16_RS08675	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY16_RS08685	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY16_RS08690	COG0737	Belongs to the 5'-nucleotidase family
GPY16_RS08695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY16_RS08700	COG3063	Type IV pilus biogenesis stability protein PilW
GPY16_RS08715	COG1451	nucleotide metabolic process
GPY16_RS08745	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY16_RS08780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY16_RS08790	COG2925	Exonuclease
GPY16_RS08795	COG1380	Effector of murein hydrolase LrgA
GPY16_RS08800	COG1346	cytolysis
GPY16_RS08825	COG1643	Atp-dependent helicase
GPY16_RS08830	COG0281	malic enzyme
GPY16_RS08835	COG2949	membrane
GPY16_RS08840	COG0471	metal ion transport
GPY16_RS08845	COG0745	RESPONSE REGULATOR receiver
GPY16_RS08845	COG3706	GGDEF domain
GPY16_RS08865	COG0492	ferredoxin-NADP+ reductase activity
GPY16_RS08870	COG4988	ABC transporter
GPY16_RS08875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY16_RS08890	COG5002	protein histidine kinase activity
GPY16_RS08890	COG5002	protein histidine kinase activity
GPY16_RS08905	COG3070	regulator of competence-specific genes
GPY16_RS08915	COG2431	L-lysine efflux transmembrane transporter activity
GPY16_RS08925	COG0076	glutamate decarboxylase activity
GPY16_RS08930	COG1737	Transcriptional regulator
GPY16_RS08935	COG1979	alcohol dehydrogenase
GPY16_RS08940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY16_RS08945	COG3273	potassium ion transport
GPY16_RS08945	COG2985	domain, Protein
GPY16_RS08950	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY16_RS08980	COG1136	(ABC) transporter
GPY16_RS08985	COG0702	epimerase
GPY16_RS08995	COG2814	Major facilitator Superfamily
GPY16_RS09005	COG1061	Type III restriction enzyme res subunit
GPY16_RS09015	COG0745	RESPONSE REGULATOR receiver
GPY16_RS09020	COG2205	protein histidine kinase activity
GPY16_RS09050	COG3313	Fe-S protein
GPY16_RS09060	COG4134	Bacterial extracellular solute-binding protein
GPY16_RS09065	COG4135	transport system, permease component
GPY16_RS09070	COG4136	ATPase activity
GPY16_RS09075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY16_RS09080	COG3604	Transcriptional regulator
GPY16_RS09085	COG1151	hydroxylamine reductase activity
GPY16_RS09090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY16_RS09100	COG0564	pseudouridine synthase activity
GPY16_RS09110	COG0733	neurotransmitter:sodium symporter activity
GPY16_RS09120	COG0626	cystathionine gamma-synthase activity
GPY16_RS09125	COG2818	Glycosylase
GPY16_RS09145	COG1983	PspC domain protein
GPY16_RS09155	COG1842	Phage shock protein A
GPY16_RS09160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY16_RS09170	COG4168	peptide transport system, permease
GPY16_RS09175	COG4171	peptide transport system, permease
GPY16_RS09185	COG4172	Belongs to the ABC transporter superfamily
GPY16_RS09200	COG1227	inorganic diphosphatase activity
GPY16_RS09230	COG0243	molybdopterin cofactor binding
GPY16_RS09235	COG3005	denitrification pathway
GPY16_RS09240	COG4459	periplasmic nitrate reductase
GPY16_RS09245	COG0390	transport system, permease component
GPY16_RS09250	COG2116	formate transmembrane transporter activity
GPY16_RS09270	COG0583	DNA-binding transcription factor activity
GPY16_RS09275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY16_RS09285	COG1435	thymidine kinase activity
GPY16_RS09295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY16_RS09300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY16_RS09305	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY16_RS09310	COG3012	SEC-C Motif Domain Protein
GPY16_RS09325	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY16_RS09330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY16_RS09335	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY16_RS09335	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY16_RS09340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY16_RS09345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY16_RS09355	COG1757	Na H antiporter
GPY16_RS09360	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY16_RS09365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY16_RS09375	COG0482	sulfurtransferase activity
GPY16_RS09385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY16_RS09405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY16_RS09420	COG1028	Short-chain dehydrogenase reductase Sdr
GPY16_RS09430	COG0501	Belongs to the peptidase M48B family
GPY16_RS09465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY16_RS09485	COG0686	Belongs to the AlaDH PNT family
GPY16_RS09495	COG0583	DNA-binding transcription factor activity
GPY16_RS09520	COG4608	Belongs to the ABC transporter superfamily
GPY16_RS09525	COG0444	Belongs to the ABC transporter superfamily
GPY16_RS09530	COG4166	transmembrane transport
GPY16_RS09535	COG4239	(ABC) transporter, permease
GPY16_RS09540	COG4174	ABC transporter (Permease)
GPY16_RS09545	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY16_RS09550	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY16_RS09555	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY16_RS09565	COG0539	negative regulation of cytoplasmic translation
GPY16_RS09575	COG0616	signal peptide processing
GPY16_RS09580	COG1028	Short-chain dehydrogenase reductase Sdr
GPY16_RS09595	COG0587	DNA-directed DNA polymerase activity
GPY16_RS09600	COG0835	chemotaxis
GPY16_RS09600	COG0784	Response regulator, receiver
GPY16_RS09605	COG1940	carbohydrate kinase activity
GPY16_RS09610	COG0469	pyruvate kinase activity
GPY16_RS09615	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY16_RS09630	COG0733	neurotransmitter:sodium symporter activity
GPY16_RS09645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY16_RS09645	COG1263	PTS System
GPY16_RS09665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY16_RS09695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY16_RS09710	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY16_RS09725	COG1530	ribonuclease E activity
GPY16_RS09730	COG0659	secondary active sulfate transmembrane transporter activity
GPY16_RS09735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY16_RS09740	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY16_RS09755	COG0489	protein tyrosine kinase activity
GPY16_RS09760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY16_RS09760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY16_RS09770	COG3088	subunit of a heme lyase
GPY16_RS09775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY16_RS09780	COG1138	Cytochrome C-type biogenesis protein
GPY16_RS09785	COG3301	Polysulphide reductase, NrfD
GPY16_RS09790	COG0437	4 iron, 4 sulfur cluster binding
GPY16_RS09795	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY16_RS09825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY16_RS09830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY16_RS09895	COG0322	excinuclease ABC activity
GPY16_RS09900	COG2197	response regulator
GPY16_RS09905	COG0417	DNA replication proofreading
GPY16_RS09910	COG5001	Diguanylate cyclase
GPY16_RS09940	COG0009	L-threonylcarbamoyladenylate synthase
GPY16_RS09945	COG0613	PHP domain protein
GPY16_RS09955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY16_RS09960	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY16_RS09965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY16_RS09970	COG0134	indole-3-glycerol-phosphate synthase activity
GPY16_RS09970	COG0135	phosphoribosylanthranilate isomerase activity
GPY16_RS09985	COG1301	dicarboxylic acid transport
GPY16_RS10000	COG1607	acyl-coa hydrolase
GPY16_RS10005	COG2350	Protein conserved in bacteria
GPY16_RS10015	COG0435	Glutathione S-transferase
GPY16_RS10025	COG0444	Belongs to the ABC transporter superfamily
GPY16_RS10030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY16_RS10035	COG0601	transmembrane transport
GPY16_RS10045	COG0314	molybdopterin synthase activity
GPY16_RS10050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY16_RS10055	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY16_RS10060	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY16_RS10070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY16_RS10105	COG4656	Part of a membrane complex involved in electron transport
GPY16_RS10115	COG4659	FMN binding
GPY16_RS10125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY16_RS10130	COG0346	lactoylglutathione lyase activity
GPY16_RS10140	COG2885	chlorophyll binding
GPY16_RS10145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY16_RS10150	COG2056	Na+-H+ antiporter family
GPY16_RS10160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY16_RS10175	COG1028	Short-chain dehydrogenase reductase Sdr
GPY16_RS10180	COG1012	belongs to the aldehyde dehydrogenase family
GPY16_RS10180	COG1454	alcohol dehydrogenase
GPY16_RS10185	COG2095	MarC family integral membrane protein
GPY16_RS10190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY16_RS10200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY16_RS10205	COG1757	Na H antiporter
GPY16_RS10220	COG3081	Nucleoid-associated protein
GPY16_RS10225	COG3082	Protein of unknown function (DUF1414)
GPY16_RS10230	COG3083	sulfuric ester hydrolase activity
GPY16_RS10255	COG0582	viral genome integration into host DNA
GPY16_RS10320	COG0569	domain protein
GPY16_RS10325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY16_RS10330	COG2731	YhcH YjgK YiaL family protein
GPY16_RS10340	COG0745	RESPONSE REGULATOR receiver
GPY16_RS10340	COG3706	GGDEF domain
GPY16_RS10350	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY16_RS10355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY16_RS10360	COG0778	Nitroreductase
GPY16_RS10365	COG1902	pentaerythritol trinitrate reductase activity
GPY16_RS10365	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY16_RS10370	COG0616	signal peptide processing
GPY16_RS10375	COG0252	asparaginase activity
GPY16_RS10380	COG3139	Protein of unknown function (DUF1315)
GPY16_RS10395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY16_RS10445	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY16_RS10450	COG1946	Acyl-CoA thioesterase
GPY16_RS10460	COG1522	sequence-specific DNA binding
GPY16_RS10465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY16_RS10480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY16_RS10540	COG0318	PFAM AMP-dependent synthetase and ligase
GPY16_RS10545	COG1441	menaquinone biosynthetic process
GPY16_RS10550	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY16_RS10565	COG1169	isochorismate synthase
GPY16_RS10570	COG0436	Aminotransferase
GPY16_RS10580	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY16_RS10710	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GPY16_RS10765	COG1555	photosystem II stabilization
GPY16_RS10770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY16_RS10775	COG0776	regulation of translation
GPY16_RS10780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY16_RS10795	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY16_RS10800	COG4191	Histidine kinase
GPY16_RS10805	COG2204	response regulator
GPY16_RS10815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY16_RS10820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY16_RS10825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY16_RS10830	COG3842	ATPase activity
GPY16_RS10850	COG2205	protein histidine kinase activity
GPY16_RS10855	COG0745	RESPONSE REGULATOR receiver
GPY16_RS10900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY16_RS10905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY16_RS10925	COG1216	Glycosyl transferase, family 2
GPY16_RS10930	COG2986	histidine ammonia-lyase
GPY16_RS10955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY16_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
GPY16_RS10980	COG5002	protein histidine kinase activity
GPY16_RS10985	COG0745	RESPONSE REGULATOR receiver
GPY16_RS10995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY16_RS11005	COG2951	lytic endotransglycosylase activity
GPY16_RS11020	COG2894	cell division
GPY16_RS11030	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY16_RS11035	COG0318	PFAM AMP-dependent synthetase and ligase
GPY16_RS11040	COG0596	Alpha beta hydrolase
GPY16_RS11055	COG1214	PFAM Peptidase M22, glycoprotease
GPY16_RS11060	COG1199	ATP-dependent helicase activity
GPY16_RS11070	COG0788	formyltetrahydrofolate deformylase activity
GPY16_RS11075	COG3102	Protein conserved in bacteria
GPY16_RS11100	COG1918	ferrous iron import across plasma membrane
GPY16_RS11110	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY16_RS11120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY16_RS11135	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY16_RS11140	COG0567	Dehydrogenase, E1 component
GPY16_RS11150	COG1053	succinate dehydrogenase
GPY16_RS11155	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY16_RS11160	COG2009	succinate dehydrogenase
GPY16_RS11170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY16_RS11180	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY16_RS11190	COG0251	oxidation-reduction process
GPY16_RS11195	COG2964	Protein conserved in bacteria
GPY16_RS11200	COG0033	Phosphoglucomutase
GPY16_RS11205	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY16_RS11210	COG0596	Alpha beta hydrolase
GPY16_RS11220	COG0716	FMN binding
GPY16_RS11235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY16_RS11240	COG1263	PTS System
GPY16_RS11240	COG2190	(PTS) system
GPY16_RS11240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY16_RS11245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY16_RS11250	COG1940	carbohydrate kinase activity
GPY16_RS11250	COG1846	Transcriptional regulator
GPY16_RS11255	COG4651	solute:proton antiporter activity
GPY16_RS11255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY16_RS11260	COG0367	asparagine synthase
GPY16_RS11270	COG3104	oligopeptide transport
GPY16_RS11280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY16_RS11290	COG0326	Molecular chaperone. Has ATPase activity
GPY16_RS11295	COG3710	Transcriptional regulator
GPY16_RS11315	COG0622	Phosphoesterase
GPY16_RS11340	COG1090	epimerase
GPY16_RS11345	COG0300	oxidoreductase activity
GPY16_RS11355	COG3118	belongs to the thioredoxin family
GPY16_RS11360	COG0330	HflC and HflK could
GPY16_RS11390	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY16_RS11395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY16_RS11400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY16_RS11405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY16_RS11410	COG2190	(PTS) system
GPY16_RS11415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY16_RS11420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY16_RS11425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY16_RS11430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY16_RS11440	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY16_RS11440	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY16_RS11455	COG4786	Flagellar basal body rod
GPY16_RS11460	COG4787	bacterial-type flagellum-dependent cell motility
GPY16_RS11465	COG1749	Flagellar hook protein flgE
GPY16_RS11470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY16_RS11475	COG1558	bacterial-type flagellum-dependent cell motility
GPY16_RS11480	COG1815	bacterial-type flagellum-dependent cell motility
GPY16_RS11485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY16_RS11490	COG0835	chemotaxis
GPY16_RS11490	COG0784	Response regulator, receiver
GPY16_RS11550	COG2608	mercury ion transmembrane transporter activity
GPY16_RS11550	COG2217	Heavy metal translocating P-type atpase
GPY16_RS11565	COG3735	TraB family
GPY16_RS11580	COG2840	Smr protein MutS2
GPY16_RS11585	COG1187	pseudouridine synthase activity
GPY16_RS11605	COG2912	Transglutaminase-like superfamily
GPY16_RS11610	COG3094	Invasion gene expression up-regulator, SirB
GPY16_RS11615	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY16_RS11635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY16_RS11730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY16_RS11735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY16_RS11740	COG1702	phosphate starvation-inducible protein PhoH
GPY16_RS11745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY16_RS11750	COG4535	Mg2 and Co2 transporter CorC
GPY16_RS11760	COG2888	peptidyl-tyrosine sulfation
GPY16_RS11765	COG0495	leucyl-tRNA aminoacylation
GPY16_RS11770	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY16_RS11775	COG1466	dna polymerase III delta subunit
GPY16_RS11780	COG0799	negative regulation of ribosome biogenesis
GPY16_RS11790	COG0768	penicillin binding
GPY16_RS11795	COG0772	Belongs to the SEDS family
GPY16_RS11800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY16_RS11805	COG1686	Belongs to the peptidase S11 family
GPY16_RS11815	COG0321	lipoyl(octanoyl) transferase activity
GPY16_RS11860	COG0366	Alpha amylase catalytic
GPY16_RS11865	COG1263	PTS System
GPY16_RS11865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY16_RS11875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY16_RS11880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY16_RS11885	COG2011	ABC-type metal ion transport system permease component
GPY16_RS11890	COG1464	Belongs to the NlpA lipoprotein family
GPY16_RS11895	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY16_RS11905	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY16_RS11905	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY16_RS11915	COG3706	GGDEF domain
GPY16_RS11920	COG1611	Belongs to the LOG family
GPY16_RS11925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY16_RS11940	COG2363	Small membrane protein
GPY16_RS11950	COG0583	DNA-binding transcription factor activity
GPY16_RS11965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY16_RS11975	COG0142	geranyltranstransferase activity
GPY16_RS11985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY16_RS11990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY16_RS12015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY16_RS12015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY16_RS12020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY16_RS12050	COG2252	PERMEase
GPY16_RS12055	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY16_RS12095	COG0590	tRNA wobble adenosine to inosine editing
GPY16_RS12100	COG0583	DNA-binding transcription factor activity
GPY16_RS12105	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY16_RS12110	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GPY16_RS12115	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY16_RS12135	COG4969	Belongs to the N-Me-Phe pilin family
GPY16_RS12180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY16_RS12185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY16_RS12190	COG0497	DNA recombination
GPY16_RS12195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY16_RS12205	COG2867	negative regulation of translational initiation
GPY16_RS12250	COG0009	L-threonylcarbamoyladenylate synthase
GPY16_RS12265	COG0583	DNA-binding transcription factor activity
GPY16_RS12275	COG1115	amino acid carrier protein
GPY16_RS12280	COG1584	GPR1 FUN34 yaaH family protein
GPY16_RS12290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY16_RS12290	COG0519	Catalyzes the synthesis of GMP from XMP
GPY16_RS12295	COG0517	IMP dehydrogenase activity
GPY16_RS12295	COG0516	GMP reductase activity
GPY16_RS12300	COG1570	exodeoxyribonuclease VII activity
GPY16_RS12310	COG2199	diguanylate cyclase activity
GPY16_RS12310	COG2203	Gaf domain
GPY16_RS12325	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY16_RS12330	COG2976	Protein conserved in bacteria
GPY16_RS12345	COG1426	Protein conserved in bacteria
GPY16_RS12365	COG2975	iron-sulfur cluster assembly
GPY16_RS12370	COG0633	Ferredoxin
GPY16_RS12375	COG0443	Heat shock 70 kDa protein
GPY16_RS12390	COG0822	iron-sulfur transferase activity
GPY16_RS12405	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY16_RS12410	COG0483	inositol monophosphate 1-phosphatase activity
GPY16_RS12415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY16_RS12420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY16_RS12425	COG1862	Preprotein translocase
GPY16_RS12435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY16_RS12445	COG0517	IMP dehydrogenase activity
GPY16_RS12455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY16_RS12460	COG0583	DNA-binding transcription factor activity
GPY16_RS12465	COG0450	alkyl hydroperoxide reductase
GPY16_RS12480	COG0704	Plays a role in the regulation of phosphate uptake
GPY16_RS12490	COG0581	inorganic phosphate transmembrane transporter activity
GPY16_RS12495	COG0573	inorganic phosphate transmembrane transporter activity
GPY16_RS12500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY16_RS12505	COG0248	Ppx GppA phosphatase
GPY16_RS12515	COG5002	protein histidine kinase activity
GPY16_RS12520	COG0745	RESPONSE REGULATOR receiver
GPY16_RS12535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY16_RS12590	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY16_RS12595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY16_RS12600	COG1605	Chorismate mutase
GPY16_RS12600	COG0077	Prephenate dehydratase
GPY16_RS12605	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY16_RS12620	COG0488	(ABC) transporter
GPY16_RS12630	COG0739	heme binding
GPY16_RS12635	COG1605	Chorismate mutase
GPY16_RS12635	COG0287	Prephenate dehydrogenase
GPY16_RS12640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY16_RS12645	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY16_RS12650	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY16_RS12670	COG1966	Carbon starvation protein
GPY16_RS12675	COG3275	phosphorelay sensor kinase activity
GPY16_RS12690	COG1047	Peptidyl-prolyl cis-trans
GPY16_RS12700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY16_RS12705	COG0196	riboflavin kinase activity
GPY16_RS12710	COG0728	peptidoglycan biosynthetic process
GPY16_RS12720	COG0640	Transcriptional regulator
GPY16_RS12725	COG0583	DNA-binding transcription factor activity
GPY16_RS12730	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY16_RS12745	COG4974	Belongs to the 'phage' integrase family
GPY16_RS12765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY16_RS12775	COG1566	PFAM secretion protein HlyD family protein
GPY16_RS12800	COG3550	peptidyl-serine autophosphorylation
GPY16_RS12825	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY16_RS12840	COG0730	response to heat
GPY16_RS12865	COG0667	Aldo Keto reductase
GPY16_RS12880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY16_RS12890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY16_RS12895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY16_RS12905	COG0716	FMN binding
GPY16_RS12920	COG0513	Belongs to the DEAD box helicase family
GPY16_RS12925	COG3022	response to hydroperoxide
GPY16_RS12930	COG1115	amino acid carrier protein
GPY16_RS12960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY16_RS12995	COG0745	RESPONSE REGULATOR receiver
GPY16_RS13005	COG2198	Histidine kinase
GPY16_RS13005	COG0784	Response regulator, receiver
GPY16_RS13005	COG5002	protein histidine kinase activity
GPY16_RS13010	COG3706	GGDEF domain
GPY16_RS13010	COG2203	Gaf domain
GPY16_RS13010	COG4251	negative regulation of phosphorylation
GPY16_RS13010	COG5001	Diguanylate cyclase
GPY16_RS13015	COG1242	4 iron, 4 sulfur cluster binding
GPY16_RS13020	COG0070	glutamate synthase
GPY16_RS13020	COG0069	glutamate synthase activity
GPY16_RS13020	COG0067	glutamate synthase
GPY16_RS13030	COG0067	glutamate synthase
GPY16_RS13030	COG0069	glutamate synthase activity
GPY16_RS13030	COG0070	glutamate synthase
GPY16_RS13035	COG0493	'glutamate synthase
GPY16_RS13045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY16_RS13060	COG2860	membrane
GPY16_RS13065	COG0583	DNA-binding transcription factor activity
GPY16_RS13070	COG0730	response to heat
GPY16_RS13085	COG0505	Belongs to the CarA family
GPY16_RS13095	COG0494	nUDIX hydrolase
GPY16_RS13100	COG0653	protein targeting
GPY16_RS13115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY16_RS13120	COG0849	cell division
GPY16_RS13125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY16_RS13130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY16_RS13140	COG0772	Belongs to the SEDS family
GPY16_RS13150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY16_RS13155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY16_RS13165	COG0768	penicillin binding
GPY16_RS13170	COG3116	cell division
GPY16_RS13185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY16_RS13190	COG3107	peptidoglycan biosynthetic process
GPY16_RS13200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY16_RS13205	COG2823	Periplasmic or secreted lipoprotein
GPY16_RS13210	COG2969	positive regulation of protein catabolic process
GPY16_RS13215	COG0625	glutathione transferase activity
GPY16_RS13220	COG2857	Cytochrome c1
GPY16_RS13225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY16_RS13230	COG0723	plastoquinol--plastocyanin reductase activity
GPY16_RS13250	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY16_RS13255	COG3105	Protein conserved in bacteria
GPY16_RS13260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY16_RS13265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY16_RS13275	COG0187	DNA topoisomerase II activity
GPY16_RS13280	COG3150	esterase
GPY16_RS13290	COG3151	Protein conserved in bacteria
GPY16_RS13295	COG0494	nUDIX hydrolase
GPY16_RS13300	COG1538	Outer membrane efflux protein
GPY16_RS13310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY16_RS13320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY16_RS13325	COG3025	triphosphatase activity
GPY16_RS13330	COG1392	Phosphate transport regulator
GPY16_RS13335	COG0306	phosphate transporter
GPY16_RS13340	COG4991	sh3 domain protein
GPY16_RS13345	COG3409	Peptidoglycan-binding domain 1 protein
GPY16_RS13345	COG3267	Type II secretory pathway component ExeA
GPY16_RS13350	COG0617	tRNA 3'-terminal CCA addition
GPY16_RS13360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY16_RS13365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY16_RS13375	COG0596	Alpha beta hydrolase
GPY16_RS13385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY16_RS13390	COG1610	YqeY-like protein
GPY16_RS13400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY16_RS13430	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY16_RS13435	COG2213	PTS system mannitol-specific
GPY16_RS13435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY16_RS13445	COG3722	fumarate hydratase activity
GPY16_RS13455	COG1349	DNA-binding transcription factor activity
GPY16_RS13460	COG0469	pyruvate kinase activity
GPY16_RS13470	COG3706	GGDEF domain
GPY16_RS13475	COG0440	acetolactate synthase activity
GPY16_RS13480	COG0028	Belongs to the TPP enzyme family
GPY16_RS13485	COG1022	Amp-dependent synthetase and ligase
GPY16_RS13515	COG0473	3-isopropylmalate dehydrogenase activity
GPY16_RS13525	COG0066	3-isopropylmalate dehydratase activity
GPY16_RS13575	COG3610	response to peptide
GPY16_RS13595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY16_RS13600	COG0142	geranyltranstransferase activity
GPY16_RS13605	COG0039	L-malate dehydrogenase activity
GPY16_RS13625	COG0589	response to stress
GPY16_RS13630	COG0204	Acyl-transferase
GPY16_RS13640	COG5007	Belongs to the BolA IbaG family
GPY16_RS13650	COG2854	intermembrane phospholipid transfer
GPY16_RS13655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY16_RS13660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY16_RS13665	COG1127	ABC transporter
GPY16_RS13675	COG0517	IMP dehydrogenase activity
GPY16_RS13675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY16_RS13690	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY16_RS13695	COG1137	ATPase activity
GPY16_RS13705	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY16_RS13710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY16_RS13715	COG1660	Displays ATPase and GTPase activities
GPY16_RS13720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY16_RS13725	COG2239	Acts as a magnesium transporter
GPY16_RS13735	COG3028	Belongs to the UPF0307 family
GPY16_RS13745	COG1178	ABC-type Fe3 transport system permease component
GPY16_RS13750	COG4143	(ABC) transporter
GPY16_RS13755	COG0163	prenyltransferase activity
GPY16_RS13760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY16_RS13780	COG2105	PFAM AIG2 family protein
GPY16_RS13785	COG2911	Protein conserved in bacteria
GPY16_RS13790	COG0729	surface antigen
GPY16_RS13805	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY16_RS13820	COG1136	(ABC) transporter
GPY16_RS13820	COG0577	efflux transmembrane transporter activity
GPY16_RS13845	COG0471	metal ion transport
GPY16_RS13845	COG3273	potassium ion transport
GPY16_RS13850	COG2895	sulfate adenylyltransferase (ATP) activity
GPY16_RS13860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY16_RS13860	COG1648	precorrin-2 dehydrogenase activity
GPY16_RS13865	COG0737	Belongs to the 5'-nucleotidase family
GPY16_RS13875	COG2153	protein acetylation
GPY16_RS13885	COG3061	Opacity-associated protein A
GPY16_RS13885	COG3266	domain, Protein
GPY16_RS13890	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY16_RS13915	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY16_RS13930	COG0201	protein transport
GPY16_RS13985	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY16_RS14030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY16_RS14040	COG3064	Membrane
GPY16_RS14065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GPY16_RS14075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY16_RS14080	COG2030	dehydratase
GPY16_RS14090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY16_RS14095	COG0438	transferase activity, transferring glycosyl groups
GPY16_RS14140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY16_RS14160	COG1596	polysaccharide export
GPY16_RS14180	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY16_RS14195	COG0859	PFAM glycosyl transferase family 9
GPY16_RS14200	COG1519	Transferase
GPY16_RS14220	COG1083	cytidylyl-transferase
GPY16_RS14240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY16_RS14245	COG2089	acid synthase
GPY16_RS14255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY16_RS14270	COG3083	sulfuric ester hydrolase activity
GPY16_RS14275	COG3642	lipopolysaccharide core region biosynthetic process
GPY16_RS14280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY16_RS14285	COG0859	PFAM glycosyl transferase family 9
GPY16_RS14290	COG0463	Glycosyl transferase, family 2
GPY16_RS14295	COG0859	PFAM glycosyl transferase family 9
GPY16_RS14330	COG2003	Belongs to the UPF0758 family
GPY16_RS14350	COG1560	Kdo2-lipid A biosynthetic process
GPY16_RS14365	COG1561	YicC-like family, N-terminal region
GPY16_RS14385	COG4608	Belongs to the ABC transporter superfamily
GPY16_RS14390	COG0444	Belongs to the ABC transporter superfamily
GPY16_RS14395	COG0747	negative chemotaxis
GPY16_RS14400	COG4239	(ABC) transporter, permease
GPY16_RS14405	COG4174	ABC transporter (Permease)
GPY16_RS14410	COG4206	TonB-dependent receptor
GPY16_RS14420	COG0811	peptide transport
GPY16_RS14425	COG0811	peptide transport
GPY16_RS14430	COG0848	biopolymer transport protein
GPY16_RS14455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY16_RS14460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY16_RS14465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY16_RS14470	COG2233	PERMEase
GPY16_RS14475	COG2205	protein histidine kinase activity
GPY16_RS14480	COG0745	RESPONSE REGULATOR receiver
GPY16_RS14485	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY16_RS14490	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY16_RS14495	COG1129	ABC transporter
GPY16_RS14515	COG4221	oxidoreductase activity
GPY16_RS14525	COG2183	response to ionizing radiation
GPY16_RS14535	COG0596	Alpha beta hydrolase
GPY16_RS14550	COG0494	nUDIX hydrolase
GPY16_RS14555	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY16_RS14565	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY16_RS14570	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY16_RS14575	COG3156	type II secretion system protein K
GPY16_RS14580	COG4795	General secretion pathway protein
GPY16_RS14585	COG2165	general secretion pathway protein
GPY16_RS14590	COG2165	general secretion pathway protein
GPY16_RS14595	COG2165	general secretion pathway protein
GPY16_RS14600	COG1459	type II secretion system
GPY16_RS14605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY16_RS14615	COG3031	protein transport across the cell outer membrane
GPY16_RS14620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY16_RS14640	COG0456	acetyltransferase
GPY16_RS14650	COG1295	ribonuclease BN
GPY16_RS14670	COG0174	glutamine synthetase
GPY16_RS14680	COG3852	Histidine kinase
GPY16_RS14685	COG2204	response regulator
GPY16_RS14690	COG3300	MHYT domain
GPY16_RS14690	COG5001	Diguanylate cyclase
GPY16_RS14695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY16_RS14720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY16_RS14725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY16_RS14725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY16_RS14735	COG0084	hydrolase, TatD family'
GPY16_RS14740	COG0805	protein transport
GPY16_RS14750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY16_RS14760	COG3165	ubiquinone biosynthetic process from chorismate
GPY16_RS14770	COG1322	Protein conserved in bacteria
GPY16_RS14865	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY16_RS14870	COG3118	belongs to the thioredoxin family
GPY16_RS14885	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY16_RS14895	COG0514	ATP-dependent DNA helicase (RecQ)
GPY16_RS14900	COG2962	Rard protein
GPY16_RS14910	COG1280	lysine exporter protein (LysE YggA)
GPY16_RS14920	COG0210	DNA helicase
GPY16_RS14960	COG0006	proline dipeptidase activity
GPY16_RS14960	COG0006	proline dipeptidase activity
GPY16_RS14980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY16_RS15000	COG2132	Multicopper oxidase
GPY16_RS15060	COG3040	lipid binding
GPY16_RS15090	COG1233	COG1233 Phytoene dehydrogenase and related
GPY16_RS15100	COG2197	response regulator
GPY16_RS15120	COG0784	Response regulator, receiver
GPY16_RS15120	COG2205	protein histidine kinase activity
GPY16_RS15125	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY16_RS15135	COG2274	protein secretion by the type I secretion system
GPY16_RS15145	COG1538	Outer membrane efflux protein
GPY16_RS15165	COG0668	transmembrane transport
GPY16_RS15190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY16_RS15195	COG0793	Belongs to the peptidase S41A family
GPY16_RS15195	COG4946	Tricorn protease homolog
GPY16_RS15210	COG1122	ATPase activity
GPY16_RS15215	COG4720	Psort location CytoplasmicMembrane, score
GPY16_RS15220	COG1566	PFAM secretion protein HlyD family protein
GPY16_RS15230	COG3706	GGDEF domain
GPY16_RS15250	COG3272	Protein of unknown function (DUF1722)
GPY16_RS15255	COG0789	Transcriptional regulator
GPY16_RS15260	COG0415	Belongs to the DNA photolyase family
GPY16_RS15265	COG1376	ErfK ybiS ycfS ynhG family protein
GPY16_RS15265	COG1388	LysM domain
GPY16_RS15275	COG0513	Belongs to the DEAD box helicase family
GPY16_RS15315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY16_RS15320	COG0573	inorganic phosphate transmembrane transporter activity
GPY16_RS15325	COG0581	inorganic phosphate transmembrane transporter activity
GPY16_RS15330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY16_RS15345	COG2304	oxidoreductase activity
GPY16_RS15365	COG0714	Associated with various cellular activities
GPY16_RS15435	COG1596	polysaccharide export
GPY16_RS15445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY16_RS15495	COG2354	Protein conserved in bacteria
GPY16_RS15505	COG0418	dihydroorotase activity
GPY16_RS15510	COG0633	Ferredoxin
GPY16_RS15510	COG3217	Mosc domain protein beta barrel domain protein
GPY16_RS15510	COG0633	Ferredoxin
GPY16_RS15510	COG3217	Mosc domain protein beta barrel domain protein
GPY16_RS15515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY16_RS15560	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY16_RS15565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY16_RS15575	COG0848	biopolymer transport protein
GPY16_RS15580	COG0811	peptide transport
GPY16_RS15585	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY16_RS15595	COG3721	Heme iron utilization protein
GPY16_RS15600	COG0748	coenzyme F420 binding
GPY16_RS15610	COG0835	chemotaxis
GPY16_RS15610	COG0784	Response regulator, receiver
GPY16_RS15615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY16_RS15620	COG0589	response to stress
GPY16_RS15625	COG0366	Alpha amylase catalytic
GPY16_RS15635	COG0840	transmembrane signaling receptor activity
GPY16_RS15670	COG0739	heme binding
GPY16_RS15675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY16_RS15690	COG2084	Dehydrogenase
GPY16_RS15715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY16_RS15735	COG0840	transmembrane signaling receptor activity
GPY16_RS15750	COG3706	GGDEF domain
GPY16_RS15755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY16_RS15755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY16_RS15760	COG1765	OsmC-like protein
GPY16_RS15765	COG2171	N-acyltransferase activity
GPY16_RS15785	COG1011	Hydrolase
GPY16_RS15810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY16_RS15815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY16_RS15815	COG2207	Transcriptional regulator
GPY16_RS15835	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY16_RS15840	COG3842	ATPase activity
GPY16_RS15860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY16_RS15865	COG0583	DNA-binding transcription factor activity
GPY16_RS15880	COG1760	l-serine dehydratase
GPY16_RS15900	COG1686	Belongs to the peptidase S11 family
GPY16_RS15920	COG1309	transcriptional regulator
GPY16_RS15925	COG1012	belongs to the aldehyde dehydrogenase family
GPY16_RS15945	COG4175	Glycine betaine
GPY16_RS15950	COG3059	membrane
GPY16_RS15985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY16_RS15990	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY16_RS15995	COG0247	lactate metabolic process
GPY16_RS16010	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPY16_RS16015	COG2133	pyrroloquinoline quinone binding
GPY16_RS16025	COG1454	alcohol dehydrogenase
GPY16_RS16030	COG0443	Heat shock 70 kDa protein
GPY16_RS16035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY16_RS16065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY16_RS16070	COG3174	membrane
GPY16_RS16095	COG0814	amino acid
GPY16_RS16100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY16_RS16125	COG2962	Rard protein
GPY16_RS16140	COG0671	phosphoesterase, PA-phosphatase related
GPY16_RS16150	COG1288	antiporter activity
GPY16_RS16165	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY16_RS16180	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY16_RS16185	COG2315	Protein conserved in bacteria
GPY16_RS16205	COG1129	ABC transporter
GPY16_RS16210	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY16_RS16215	COG1879	ABC-type sugar transport system periplasmic component
GPY16_RS16220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY16_RS16225	COG1609	Transcriptional regulator
GPY16_RS16235	COG0784	Response regulator, receiver
GPY16_RS16235	COG0835	chemotaxis
GPY16_RS16245	COG0456	acetyltransferase
GPY16_RS16250	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY16_RS16260	COG0420	3'-5' exonuclease activity
GPY16_RS16265	COG0419	ATPase involved in DNA repair
GPY16_RS16275	COG0583	DNA-binding transcription factor activity
GPY16_RS16295	COG4964	Belongs to the GSP D family
GPY16_RS16380	COG0471	metal ion transport
GPY16_RS16385	COG3290	protein histidine kinase activity
GPY16_RS16395	COG0110	maltose O-acetyltransferase activity
GPY16_RS16415	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY16_RS16420	COG4605	iron ion homeostasis
GPY16_RS16425	COG4604	ABC transporter, ATP-binding protein
GPY16_RS16430	COG0789	Transcriptional regulator
GPY16_RS16460	COG1289	transmembrane transporter activity
GPY16_RS16475	COG1879	ABC-type sugar transport system periplasmic component
GPY16_RS16500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPY16_RS16505	COG3005	denitrification pathway
GPY16_RS16530	COG0513	Belongs to the DEAD box helicase family
GPY16_RS16540	COG5001	Diguanylate cyclase
GPY16_RS16540	COG1716	ATPase activity
GPY16_RS16565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY16_RS16580	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY16_RS16585	COG0513	Belongs to the DEAD box helicase family
GPY16_RS16595	COG3119	arylsulfatase activity
GPY16_RS16605	COG3119	arylsulfatase activity
GPY16_RS16610	COG0641	radical SAM
GPY16_RS16615	COG0714	Associated with various cellular activities
GPY16_RS16650	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
GPY16_RS16660	COG0641	radical SAM
GPY16_RS16690	COG2814	Major facilitator Superfamily
GPY16_RS16730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY16_RS16745	COG1132	(ABC) transporter
GPY16_RS16750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY16_RS16755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY16_RS16755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY16_RS16765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY16_RS16810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY16_RS16810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY16_RS16810	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY16_RS16815	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY16_RS16820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY16_RS16820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY16_RS16825	COG1609	Transcriptional regulator
GPY16_RS16850	COG0469	pyruvate kinase activity
GPY16_RS16855	COG2271	Major facilitator Superfamily
GPY16_RS16860	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY16_RS16865	COG4191	Histidine kinase
GPY16_RS16875	COG1979	alcohol dehydrogenase
GPY16_RS16880	COG2207	Transcriptional regulator
GPY16_RS16890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY16_RS16900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY16_RS16915	COG3437	response regulator, receiver
GPY16_RS16915	COG0784	Response regulator, receiver
GPY16_RS16920	COG0546	phosphoglycolate phosphatase activity
GPY16_RS16935	COG0513	Belongs to the DEAD box helicase family
GPY16_RS16950	COG3038	cytochrome b561
GPY16_RS16965	COG0583	DNA-binding transcription factor activity
GPY16_RS16975	COG3593	DNA synthesis involved in DNA repair
GPY16_RS16980	COG0737	Belongs to the 5'-nucleotidase family
GPY16_RS17015	COG2267	carboxylic ester hydrolase activity
GPY16_RS17020	COG2067	long-chain fatty acid transport protein
GPY16_RS17035	COG2050	protein possibly involved in aromatic compounds catabolism
GPY16_RS17045	COG4533	DNA binding
GPY16_RS17055	COG0366	Alpha amylase catalytic
GPY16_RS17060	COG0583	DNA-binding transcription factor activity
GPY16_RS17080	COG0484	heat shock protein binding
GPY16_RS17095	COG1716	ATPase activity
GPY16_RS17095	COG5001	Diguanylate cyclase
GPY16_RS17100	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY16_RS17110	COG4181	ATPase activity
GPY16_RS17115	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY16_RS17120	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY16_RS17120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY16_RS17125	COG1984	allophanate hydrolase subunit 2
GPY16_RS17130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY16_RS17135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY16_RS17145	COG3447	MASE1 domain protein
GPY16_RS17145	COG5002	protein histidine kinase activity
GPY16_RS17145	COG5001	Diguanylate cyclase
GPY16_RS17155	COG0583	DNA-binding transcription factor activity
GPY16_RS17160	COG1042	CoA-binding domain protein
GPY16_RS17160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY16_RS17160	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY16_RS17170	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY16_RS17180	COG0023	Translation Initiation Factor
GPY16_RS17185	COG3140	Belongs to the UPF0181 family
GPY16_RS17200	COG0745	RESPONSE REGULATOR receiver
GPY16_RS17210	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY16_RS17215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY16_RS17230	COG3706	GGDEF domain
GPY16_RS17240	COG0745	RESPONSE REGULATOR receiver
GPY16_RS17250	COG1846	Transcriptional regulator
GPY16_RS17255	COG0697	spore germination
GPY16_RS17265	COG4149	molybdate abc transporter
GPY16_RS17270	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY16_RS17290	COG4067	protein conserved in archaea
GPY16_RS17290	COG0189	ligase activity
GPY16_RS17300	COG0840	transmembrane signaling receptor activity
GPY16_RS17305	COG0602	queuosine metabolic process
GPY16_RS17310	COG1328	CTP reductase activity
GPY16_RS17365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY16_RS17370	COG3118	belongs to the thioredoxin family
GPY16_RS17385	COG0534	Mate efflux family protein
GPY16_RS17405	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY16_RS17420	COG0848	biopolymer transport protein
GPY16_RS17425	COG0811	peptide transport
GPY16_RS17430	COG0811	peptide transport
GPY16_RS17460	COG2146	nitrite reductase [NAD(P)H] activity
GPY16_RS17465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY16_RS17500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY16_RS17510	COG2203	Gaf domain
GPY16_RS17510	COG3706	GGDEF domain
GPY16_RS17510	COG4251	negative regulation of phosphorylation
GPY16_RS17510	COG5001	Diguanylate cyclase
GPY16_RS17520	COG0010	Belongs to the arginase family
GPY16_RS17525	COG0513	Belongs to the DEAD box helicase family
GPY16_RS17535	COG0523	cobalamin synthesis protein
GPY16_RS17545	COG2199	diguanylate cyclase activity
GPY16_RS17560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY16_RS17565	COG1116	anion transmembrane transporter activity
GPY16_RS17570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY16_RS17575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY16_RS17575	COG1116	anion transmembrane transporter activity
GPY16_RS17580	COG3707	response regulator
GPY16_RS17595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY16_RS17595	COG1648	precorrin-2 dehydrogenase activity
GPY16_RS17600	COG0243	molybdopterin cofactor binding
GPY16_RS17605	COG1214	PFAM Peptidase M22, glycoprotease
GPY16_RS17605	COG0456	acetyltransferase
GPY16_RS17610	COG0366	Alpha amylase catalytic
GPY16_RS17615	COG0840	transmembrane signaling receptor activity
GPY16_RS17620	COG0840	transmembrane signaling receptor activity
GPY16_RS17635	COG2271	Major facilitator Superfamily
GPY16_RS17640	COG0584	glycerophosphoryl diester phosphodiesterase
GPY16_RS17645	COG0312	modulator of DNA gyrase
GPY16_RS17650	COG0312	modulator of DNA gyrase
GPY16_RS17660	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY16_RS17665	COG1704	LemA family
GPY16_RS17670	COG0501	Belongs to the peptidase M48B family
GPY16_RS17715	COG3209	COG3209 Rhs family protein
GPY16_RS17730	COG3501	Rhs element vgr protein
GPY16_RS17785	COG0631	protein serine/threonine phosphatase activity
GPY16_RS17820	COG0515	serine threonine protein kinase
GPY16_RS17820	COG2815	serine threonine protein kinase
GPY16_RS17840	COG3530	Putative quorum-sensing-regulated virulence factor
GPY16_RS17865	COG3186	Phenylalanine-4-hydroxylase
GPY16_RS17870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY16_RS17895	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY16_RS17905	COG4191	Histidine kinase
GPY16_RS17905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY16_RS17910	COG3437	response regulator, receiver
GPY16_RS17910	COG0784	Response regulator, receiver
GPY16_RS17965	COG1073	alpha beta
GPY16_RS17965	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GPY16_RS17965	COG3064	Membrane
GPY16_RS17970	COG2994	toxin metabolic process
GPY16_RS18005	COG5642	Protein of unknown function (DUF2384)
GPY16_RS18015	COG1028	Short-chain dehydrogenase reductase Sdr
GPY16_RS18025	COG1024	Enoyl-CoA hydratase
GPY16_RS18030	COG1024	Enoyl-CoA hydratase
GPY16_RS18045	COG0183	Belongs to the thiolase family
GPY16_RS18050	COG0789	Transcriptional regulator
GPY16_RS18055	COG1960	acyl-CoA dehydrogenase activity
GPY16_RS18060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY16_RS18065	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY16_RS18075	COG0450	alkyl hydroperoxide reductase
GPY16_RS18085	COG1278	Cold shock
GPY16_RS18100	COG1309	transcriptional regulator
GPY16_RS18105	COG2130	NADP-dependent
GPY16_RS18120	COG0457	Tetratricopeptide repeat
GPY16_RS18120	COG3710	Transcriptional regulator
GPY16_RS18135	COG2197	response regulator
GPY16_RS18140	COG3851	Histidine kinase
GPY16_RS18145	COG2271	Major facilitator Superfamily
GPY16_RS18150	COG1482	cell wall glycoprotein biosynthetic process
GPY16_RS18160	COG2203	Gaf domain
GPY16_RS18160	COG2199	diguanylate cyclase activity
GPY16_RS18170	COG3036	rescue of stalled ribosome
GPY16_RS18175	COG1278	Cold shock
GPY16_RS18205	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY16_RS18210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY16_RS18215	COG0840	transmembrane signaling receptor activity
GPY16_RS18235	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY16_RS18245	COG4989	oxidoreductase activity
GPY16_RS18270	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY16_RS18280	COG0303	'Molybdopterin
GPY16_RS18285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY16_RS18295	COG2897	thiosulfate sulfurtransferase activity
GPY16_RS18315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY16_RS18335	COG0840	transmembrane signaling receptor activity
GPY16_RS18340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY16_RS18350	COG0109	protoheme IX farnesyltransferase activity
GPY16_RS18355	COG1612	heme a metabolic process
GPY16_RS18380	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY16_RS18385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY16_RS18390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY16_RS18395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY16_RS18405	COG1280	lysine exporter protein (LysE YggA)
GPY16_RS18430	COG1846	Transcriptional regulator
GPY16_RS18435	COG1764	response to oxidative stress
GPY16_RS18445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY16_RS18460	COG0697	spore germination
GPY16_RS18475	COG2814	Major facilitator Superfamily
GPY16_RS18480	COG0583	DNA-binding transcription factor activity
GPY16_RS18485	COG2203	Gaf domain
GPY16_RS18485	COG3706	GGDEF domain
GPY16_RS18485	COG4251	negative regulation of phosphorylation
GPY16_RS18485	COG5001	Diguanylate cyclase
GPY16_RS18490	COG0251	oxidation-reduction process
GPY16_RS18505	COG4145	pantothenate transmembrane transporter activity
GPY16_RS18515	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GPY16_RS18525	COG0837	glucose binding
GPY16_RS18525	COG1737	Transcriptional regulator
GPY16_RS18535	COG1131	(ABC) transporter
GPY16_RS18540	COG0842	Transport permease protein
GPY16_RS18565	COG1846	Transcriptional regulator
GPY16_RS18580	COG0513	Belongs to the DEAD box helicase family
GPY16_RS18605	COG3568	Endonuclease Exonuclease Phosphatase
GPY16_RS18625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY16_RS18670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY16_RS18670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY16_RS18690	COG2197	response regulator
GPY16_RS18695	COG3850	Histidine kinase
GPY16_RS18700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY16_RS18710	COG0243	molybdopterin cofactor binding
GPY16_RS18720	COG3005	denitrification pathway
GPY16_RS18730	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY16_RS18735	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY16_RS18740	COG1737	Transcriptional regulator
GPY16_RS18745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY16_RS18750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY16_RS18755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY16_RS18760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY16_RS18770	COG1940	carbohydrate kinase activity
GPY16_RS18775	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY16_RS18795	COG0183	Belongs to the thiolase family
GPY16_RS18805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY16_RS18810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY16_RS18860	COG2827	Endonuclease containing a URI domain
GPY16_RS18865	COG3132	Protein of unknown function, DUF480
GPY16_RS18885	COG5002	protein histidine kinase activity
GPY16_RS18885	COG2205	protein histidine kinase activity
GPY16_RS18885	COG0784	Response regulator, receiver
GPY16_RS18910	COG0583	DNA-binding transcription factor activity
GPY16_RS18935	COG1522	sequence-specific DNA binding
GPY16_RS18940	COG0531	amino acid
GPY16_RS18945	COG0121	glutamine amidotransferase
GPY16_RS18960	COG2205	protein histidine kinase activity
GPY16_RS18965	COG0745	RESPONSE REGULATOR receiver
GPY16_RS18990	COG2239	Acts as a magnesium transporter
GPY16_RS19000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY16_RS19005	COG0402	S-adenosylhomocysteine deaminase activity
GPY16_RS19010	COG1067	ATP-dependent peptidase activity
GPY16_RS19020	COG4172	Belongs to the ABC transporter superfamily
GPY16_RS19025	COG1505	serine-type exopeptidase activity
GPY16_RS19030	COG0583	DNA-binding transcription factor activity
GPY16_RS19035	COG1620	l-lactate permease
GPY16_RS19045	COG1139	Iron-sulfur cluster binding protein
GPY16_RS19070	COG2814	Major facilitator Superfamily
GPY16_RS19110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY16_RS19125	COG3015	lipoprotein NlpE involved in copper resistance
GPY16_RS19130	COG1126	abc transporter atp-binding protein
GPY16_RS19135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY16_RS19140	COG4215	(ABC) transporter
GPY16_RS19145	COG4160	amino acid transport
GPY16_RS19160	COG5001	Diguanylate cyclase
GPY16_RS19160	COG5002	protein histidine kinase activity
GPY16_RS19165	COG2755	lipolytic protein G-D-S-L family
GPY16_RS19175	COG0840	transmembrane signaling receptor activity
GPY16_RS19180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY16_RS19210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY16_RS19215	COG1028	Short-chain dehydrogenase reductase Sdr
GPY16_RS19220	COG1169	isochorismate synthase
GPY16_RS19225	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY16_RS19245	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY16_RS19255	COG4607	ABC-type enterochelin transport system periplasmic component
GPY16_RS19260	COG1629	transport
GPY16_RS19260	COG4774	siderophore transport
GPY16_RS19275	COG0189	ligase activity
GPY16_RS19275	COG4067	protein conserved in archaea
GPY16_RS19300	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY16_RS19320	COG0814	amino acid
GPY16_RS19325	COG0488	(ABC) transporter
GPY16_RS19340	COG1609	Transcriptional regulator
GPY16_RS19345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY16_RS19360	COG0242	peptide deformylase activity
GPY16_RS19370	COG1253	flavin adenine dinucleotide binding
GPY16_RS19375	COG1012	belongs to the aldehyde dehydrogenase family
GPY16_RS19380	COG3284	Transcriptional regulator
GPY16_RS19390	COG1879	ABC-type sugar transport system periplasmic component
GPY16_RS19395	COG0625	glutathione transferase activity
GPY16_RS19405	COG0384	phenazine biosynthesis protein PhzF
GPY16_RS19410	COG2197	response regulator
GPY16_RS19415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY16_RS19420	COG0673	inositol 2-dehydrogenase activity
GPY16_RS19445	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY16_RS19455	COG0583	DNA-binding transcription factor activity
GPY16_RS19465	COG0583	DNA-binding transcription factor activity
GPY16_RS19470	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY16_RS19490	COG1566	PFAM secretion protein HlyD family protein
GPY16_RS19510	COG2194	sulfuric ester hydrolase activity
GPY16_RS19540	COG0583	DNA-binding transcription factor activity
GPY16_RS19545	COG0583	DNA-binding transcription factor activity
GPY16_RS19560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY16_RS19565	COG0700	Nucleoside recognition
GPY16_RS19570	COG3366	ferrous iron transmembrane transporter activity
GPY16_RS19580	COG0366	Alpha amylase catalytic
GPY16_RS19585	COG0823	Involved in the tonB-independent uptake of proteins
GPY16_RS19590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY16_RS19600	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY16_RS19605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY16_RS19620	COG0800	Aldolase
GPY16_RS19625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY16_RS19630	COG0697	spore germination
GPY16_RS19640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY16_RS19650	COG1917	Cupin 2, conserved barrel domain protein
GPY16_RS19660	COG1028	Short-chain dehydrogenase reductase Sdr
GPY16_RS19690	COG3153	acetyltransferase
GPY16_RS19690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY16_RS19705	COG0668	transmembrane transport
GPY16_RS19735	COG0494	nUDIX hydrolase
GPY16_RS19740	COG1881	PFAM PEBP family protein
GPY16_RS19745	COG2207	Transcriptional regulator
GPY16_RS19750	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY16_RS19770	COG0745	RESPONSE REGULATOR receiver
GPY16_RS19775	COG2205	protein histidine kinase activity
GPY16_RS19795	COG0454	-acetyltransferase
GPY16_RS19800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY16_RS19825	COG1858	cytochrome C peroxidase
GPY16_RS19840	COG2207	Transcriptional regulator
GPY16_RS19845	COG2814	Major facilitator Superfamily
GPY16_RS19875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY16_RS19885	COG0583	DNA-binding transcription factor activity
GPY16_RS19910	COG0513	Belongs to the DEAD box helicase family
GPY16_RS19945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY16_RS19955	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY16_RS19975	COG3437	response regulator, receiver
GPY16_RS19985	COG0579	oxidoreductase
GPY16_RS20015	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY16_RS20030	COG2205	protein histidine kinase activity
GPY16_RS20050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY16_RS20065	COG3706	GGDEF domain
GPY16_RS20075	COG1280	lysine exporter protein (LysE YggA)
GPY16_RS20090	COG2176	DNA-directed DNA polymerase activity
GPY16_RS20095	COG0577	efflux transmembrane transporter activity
GPY16_RS20095	COG1136	(ABC) transporter
GPY16_RS20100	COG1136	(ABC) transporter
GPY16_RS20100	COG0577	efflux transmembrane transporter activity
GPY16_RS20130	COG1120	ATPase activity
GPY16_RS20135	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY16_RS20165	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY16_RS20170	COG3716	PTS system mannose fructose sorbose family IID component
GPY16_RS20180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY16_RS20185	COG2222	sugar isomerase
GPY16_RS20195	COG1349	DNA-binding transcription factor activity
GPY16_RS20200	COG1349	DNA-binding transcription factor activity
GPY16_RS20205	COG0697	spore germination
GPY16_RS20230	COG3706	GGDEF domain
GPY16_RS20230	COG0745	RESPONSE REGULATOR receiver
GPY16_RS20235	COG5002	protein histidine kinase activity
GPY16_RS20235	COG3447	MASE1 domain protein
GPY16_RS20235	COG5001	Diguanylate cyclase
GPY16_RS20250	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY16_RS20275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY16_RS20280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY16_RS20300	COG0840	transmembrane signaling receptor activity
GPY16_RS20315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY16_RS20335	COG0583	DNA-binding transcription factor activity
GPY16_RS20340	COG1486	melibiose metabolic process
GPY16_RS20360	COG2258	MOSC domain
GPY16_RS20380	COG1335	isochorismatase
GPY16_RS20385	COG0513	Belongs to the DEAD box helicase family
GPY16_RS20395	COG2186	Transcriptional regulator
GPY16_RS20405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY16_RS20415	COG0246	Mannitol dehydrogenase
GPY16_RS20420	COG1904	glucuronate isomerase
GPY16_RS20425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY16_RS20430	COG0800	Aldolase
GPY16_RS20445	COG1028	Short-chain dehydrogenase reductase Sdr
GPY16_RS20450	COG2814	Major facilitator Superfamily
GPY16_RS20460	COG1902	pentaerythritol trinitrate reductase activity
GPY16_RS20485	COG0583	DNA-binding transcription factor activity
GPY16_RS20525	COG0561	phosphatase activity
GPY16_RS20530	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPY16_RS20535	COG3623	hexulose-6-phosphate isomerase
GPY16_RS20550	COG1132	(ABC) transporter
GPY16_RS20555	COG5492	domain, Protein
GPY16_RS20560	COG5426	von Willebrand factor, type A
GPY16_RS20570	COG1028	Short-chain dehydrogenase reductase Sdr
GPY16_RS20580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY16_RS20585	COG0659	secondary active sulfate transmembrane transporter activity
GPY16_RS20615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY16_RS20620	COG0601	transmembrane transport
GPY16_RS20625	COG0747	negative chemotaxis
GPY16_RS20635	COG3119	arylsulfatase activity
GPY16_RS20640	COG0641	radical SAM
GPY16_RS20645	COG3119	arylsulfatase activity
GPY16_RS20650	COG3119	arylsulfatase activity
GPY16_RS20655	COG5492	domain, Protein
GPY16_RS20675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY16_RS20710	COG2204	response regulator
GPY16_RS20740	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY16_RS20745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY16_RS20775	COG0110	maltose O-acetyltransferase activity
GPY16_RS20785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY16_RS20785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY16_RS20820	COG0406	alpha-ribazole phosphatase activity
GPY16_RS20840	COG0419	ATPase involved in DNA repair
GPY16_RS20865	COG0745	RESPONSE REGULATOR receiver
GPY16_RS20865	COG3706	GGDEF domain
GPY16_RS20875	COG0840	transmembrane signaling receptor activity
GPY16_RS20880	COG2201	protein-glutamate methylesterase activity
GPY16_RS20885	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPY16_RS20890	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY16_RS20895	COG0840	transmembrane signaling receptor activity
GPY16_RS20900	COG0835	chemotaxis
GPY16_RS20915	COG0745	RESPONSE REGULATOR receiver
GPY16_RS20925	COG1444	tRNA N-acetyltransferase activity
GPY16_RS20950	COG4608	Belongs to the ABC transporter superfamily
GPY16_RS20955	COG0444	Belongs to the ABC transporter superfamily
GPY16_RS20985	COG0217	transcriptional regulatory protein
GPY16_RS21000	COG1136	(ABC) transporter
GPY16_RS21005	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY16_RS21020	COG3275	phosphorelay sensor kinase activity
GPY16_RS21040	COG0786	glutamate:sodium symporter activity
GPY16_RS21045	COG0786	glutamate:sodium symporter activity
GPY16_RS21090	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY16_RS21095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY16_RS21105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY16_RS21125	COG1309	transcriptional regulator
GPY16_RS21150	COG1741	Belongs to the pirin family
GPY16_RS21160	COG5001	Diguanylate cyclase
GPY16_RS21190	COG3706	GGDEF domain
GPY16_RS21245	COG1982	Orn Lys Arg decarboxylase major
GPY16_RS21250	COG0531	amino acid
GPY16_RS21260	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY16_RS21265	COG1162	GTPase activity
GPY16_RS21270	COG2847	Copper chaperone PCu(A)C
GPY16_RS21275	COG1999	signal sequence binding
GPY16_RS21305	COG0058	SHG alpha-glucan phosphorylase activity
GPY16_RS21310	COG1640	4-alpha-glucanotransferase
GPY16_RS21315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY16_RS21320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY16_RS21360	COG0560	Phosphoserine phosphatase
GPY16_RS21380	COG1012	belongs to the aldehyde dehydrogenase family
GPY16_RS21385	COG0625	glutathione transferase activity
GPY16_RS21390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY16_RS21395	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY16_RS21400	COG0612	Peptidase, M16
GPY16_RS21410	COG0583	DNA-binding transcription factor activity
GPY16_RS21420	COG0642	Histidine kinase
GPY16_RS21425	COG0745	RESPONSE REGULATOR receiver
GPY16_RS21435	COG1028	Short-chain dehydrogenase reductase Sdr
GPY16_RS21450	COG2199	diguanylate cyclase activity
GPY16_RS21465	COG1609	Transcriptional regulator
GPY16_RS21480	COG0395	ABC-type sugar transport system, permease component
GPY16_RS21485	COG2723	6-phospho-beta-galactosidase activity
GPY16_RS21495	COG1609	Transcriptional regulator
GPY16_RS21505	COG0747	negative chemotaxis
GPY16_RS21515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY16_RS21520	COG0444	Belongs to the ABC transporter superfamily
GPY16_RS21525	COG4608	Belongs to the ABC transporter superfamily
GPY16_RS21535	COG1609	Transcriptional regulator
GPY16_RS21550	COG4580	involved in the transport of maltose and maltodextrins
GPY16_RS21565	COG0534	Mate efflux family protein
GPY16_RS21575	COG1566	PFAM secretion protein HlyD family protein
GPY16_RS21600	COG0564	pseudouridine synthase activity
GPY16_RS21605	COG3706	GGDEF domain
GPY16_RS21625	COG1609	Transcriptional regulator
GPY16_RS21635	COG1129	ABC transporter
GPY16_RS21645	COG3250	beta-galactosidase activity
GPY16_RS21655	COG2211	Major facilitator Superfamily
GPY16_RS21660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY16_RS21665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY16_RS21670	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY16_RS21675	COG2188	Transcriptional regulator
GPY16_RS21680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY16_RS21680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY16_RS21680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY16_RS21685	COG0383	alpha-mannosidase activity
GPY16_RS21690	COG1929	Belongs to the glycerate kinase type-1 family
GPY16_RS21695	COG1482	cell wall glycoprotein biosynthetic process
GPY16_RS21750	COG1482	cell wall glycoprotein biosynthetic process
GPY16_RS21760	COG2207	Transcriptional regulator
GPY16_RS21770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY16_RS21775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY16_RS21780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY16_RS21790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY16_RS21795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY16_RS21795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY16_RS21795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY16_RS21810	COG3383	formate dehydrogenase (NAD+) activity
GPY16_RS21820	COG1609	Transcriptional regulator
GPY16_RS21825	COG1263	PTS System
GPY16_RS21825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY16_RS21830	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GPY16_RS21835	COG1482	cell wall glycoprotein biosynthetic process
GPY16_RS21840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY16_RS21845	COG0583	DNA-binding transcription factor activity
GPY16_RS21880	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY16_RS21895	COG0583	DNA-binding transcription factor activity
GPY16_RS21900	COG1733	regulation of RNA biosynthetic process
GPY16_RS21920	COG0137	argininosuccinate synthase activity
GPY16_RS21930	COG1301	dicarboxylic acid transport
GPY16_RS21975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY16_RS21980	COG2175	clavaminate synthase activity
GPY16_RS22010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY16_RS22020	COG3706	GGDEF domain
GPY16_RS22035	COG2356	endonuclease I
GPY16_RS22050	COG1368	sulfuric ester hydrolase activity
GPY16_RS22055	COG2194	sulfuric ester hydrolase activity
GPY16_RS22060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY16_RS22065	COG2205	protein histidine kinase activity
GPY16_RS22070	COG0745	RESPONSE REGULATOR receiver
GPY16_RS22085	COG4221	oxidoreductase activity
GPY16_RS22110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY16_RS22115	COG0076	glutamate decarboxylase activity
GPY16_RS22130	COG0561	phosphatase activity
GPY16_RS22150	COG0351	phosphomethylpyrimidine kinase
GPY16_RS22215	COG2814	Major facilitator Superfamily
GPY16_RS22235	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY16_RS22240	COG4771	TonB-dependent receptor
GPY16_RS22260	COG0393	Putative heavy-metal-binding
GPY16_RS22275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY16_RS22285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY16_RS22305	COG0753	catalase activity
GPY16_RS22320	COG0346	lactoylglutathione lyase activity
GPY16_RS22330	COG2211	Major facilitator Superfamily
GPY16_RS22345	COG3240	lipase activity