locus-tag	class	description
GPY41_RS00015	COG1012	belongs to the aldehyde dehydrogenase family
GPY41_RS00020	COG3284	Transcriptional regulator
GPY41_RS00030	COG1879	ABC-type sugar transport system periplasmic component
GPY41_RS00045	COG0384	phenazine biosynthesis protein PhzF
GPY41_RS00050	COG2197	response regulator
GPY41_RS00055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY41_RS00060	COG0673	inositol 2-dehydrogenase activity
GPY41_RS00085	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY41_RS00095	COG0583	DNA-binding transcription factor activity
GPY41_RS00100	COG2194	sulfuric ester hydrolase activity
GPY41_RS00130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY41_RS00135	COG0700	Nucleoside recognition
GPY41_RS00140	COG3366	ferrous iron transmembrane transporter activity
GPY41_RS00150	COG0366	Alpha amylase catalytic
GPY41_RS00155	COG0823	Involved in the tonB-independent uptake of proteins
GPY41_RS00160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY41_RS00200	COG0800	Aldolase
GPY41_RS00205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY41_RS00210	COG0697	spore germination
GPY41_RS00260	COG1917	Cupin 2, conserved barrel domain protein
GPY41_RS00270	COG1028	Short-chain dehydrogenase reductase Sdr
GPY41_RS00320	COG0668	transmembrane transport
GPY41_RS00350	COG0494	nUDIX hydrolase
GPY41_RS00355	COG1881	PFAM PEBP family protein
GPY41_RS00360	COG2207	Transcriptional regulator
GPY41_RS00380	COG0745	RESPONSE REGULATOR receiver
GPY41_RS00385	COG2205	protein histidine kinase activity
GPY41_RS00405	COG0454	-acetyltransferase
GPY41_RS00410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY41_RS00435	COG1858	cytochrome C peroxidase
GPY41_RS00450	COG2207	Transcriptional regulator
GPY41_RS00455	COG2814	Major facilitator Superfamily
GPY41_RS00485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY41_RS00495	COG0583	DNA-binding transcription factor activity
GPY41_RS00520	COG0513	Belongs to the DEAD box helicase family
GPY41_RS00555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY41_RS00565	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY41_RS00585	COG3437	response regulator, receiver
GPY41_RS00595	COG0579	oxidoreductase
GPY41_RS00625	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY41_RS00640	COG2205	protein histidine kinase activity
GPY41_RS00675	COG2176	DNA-directed DNA polymerase activity
GPY41_RS00680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY41_RS00680	COG1263	PTS System
GPY41_RS00690	COG2188	Transcriptional regulator
GPY41_RS00695	COG1136	(ABC) transporter
GPY41_RS00695	COG0577	efflux transmembrane transporter activity
GPY41_RS00700	COG1136	(ABC) transporter
GPY41_RS00700	COG0577	efflux transmembrane transporter activity
GPY41_RS00730	COG1120	ATPase activity
GPY41_RS00735	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY41_RS00765	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS00770	COG3716	PTS system mannose fructose sorbose family IID component
GPY41_RS00780	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY41_RS00785	COG2222	sugar isomerase
GPY41_RS00795	COG1349	DNA-binding transcription factor activity
GPY41_RS00800	COG1349	DNA-binding transcription factor activity
GPY41_RS00805	COG2200	EAL domain
GPY41_RS00810	COG0697	spore germination
GPY41_RS00830	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY41_RS00855	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY41_RS00860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY41_RS00880	COG0840	transmembrane signaling receptor activity
GPY41_RS00895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY41_RS00925	COG2258	MOSC domain
GPY41_RS00940	COG0463	Glycosyl transferase, family 2
GPY41_RS00950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY41_RS00975	COG2207	Transcriptional regulator
GPY41_RS00975	COG1917	Cupin 2, conserved barrel domain protein
GPY41_RS00980	COG1335	isochorismatase
GPY41_RS00985	COG0513	Belongs to the DEAD box helicase family
GPY41_RS00995	COG2186	Transcriptional regulator
GPY41_RS01005	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY41_RS01015	COG0246	Mannitol dehydrogenase
GPY41_RS01020	COG1904	glucuronate isomerase
GPY41_RS01025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY41_RS01030	COG0800	Aldolase
GPY41_RS01050	COG1902	pentaerythritol trinitrate reductase activity
GPY41_RS01085	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPY41_RS01090	COG3623	hexulose-6-phosphate isomerase
GPY41_RS01105	COG1132	(ABC) transporter
GPY41_RS01125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY41_RS01160	COG2204	response regulator
GPY41_RS01190	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY41_RS01195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY41_RS01230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY41_RS01230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY41_RS01255	COG0406	alpha-ribazole phosphatase activity
GPY41_RS01270	COG0210	DNA helicase
GPY41_RS01275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY41_RS01285	COG0745	RESPONSE REGULATOR receiver
GPY41_RS01285	COG3706	GGDEF domain
GPY41_RS01295	COG0840	transmembrane signaling receptor activity
GPY41_RS01300	COG2201	protein-glutamate methylesterase activity
GPY41_RS01305	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPY41_RS01310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY41_RS01315	COG0840	transmembrane signaling receptor activity
GPY41_RS01320	COG0835	chemotaxis
GPY41_RS01335	COG0745	RESPONSE REGULATOR receiver
GPY41_RS01345	COG1444	tRNA N-acetyltransferase activity
GPY41_RS01370	COG4608	Belongs to the ABC transporter superfamily
GPY41_RS01375	COG0444	Belongs to the ABC transporter superfamily
GPY41_RS01405	COG0217	transcriptional regulatory protein
GPY41_RS01425	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY41_RS01440	COG3275	phosphorelay sensor kinase activity
GPY41_RS01460	COG0786	glutamate:sodium symporter activity
GPY41_RS01465	COG0786	glutamate:sodium symporter activity
GPY41_RS01510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY41_RS01515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY41_RS01520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY41_RS01545	COG1309	transcriptional regulator
GPY41_RS01570	COG1741	Belongs to the pirin family
GPY41_RS01580	COG5001	Diguanylate cyclase
GPY41_RS01595	COG3706	GGDEF domain
GPY41_RS01650	COG1982	Orn Lys Arg decarboxylase major
GPY41_RS01655	COG0531	amino acid
GPY41_RS01690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY41_RS01695	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY41_RS01700	COG1162	GTPase activity
GPY41_RS01705	COG2847	Copper chaperone PCu(A)C
GPY41_RS01710	COG1999	signal sequence binding
GPY41_RS01745	COG0058	SHG alpha-glucan phosphorylase activity
GPY41_RS01750	COG1640	4-alpha-glucanotransferase
GPY41_RS01755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY41_RS01760	COG0840	transmembrane signaling receptor activity
GPY41_RS01765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY41_RS01800	COG0560	Phosphoserine phosphatase
GPY41_RS01810	COG1012	belongs to the aldehyde dehydrogenase family
GPY41_RS01815	COG0625	glutathione transferase activity
GPY41_RS01825	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY41_RS01830	COG0612	Peptidase, M16
GPY41_RS01840	COG0583	DNA-binding transcription factor activity
GPY41_RS01850	COG0642	Histidine kinase
GPY41_RS01855	COG0745	RESPONSE REGULATOR receiver
GPY41_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
GPY41_RS01880	COG2199	diguanylate cyclase activity
GPY41_RS01900	COG1609	Transcriptional regulator
GPY41_RS01915	COG0395	ABC-type sugar transport system, permease component
GPY41_RS01920	COG2723	6-phospho-beta-galactosidase activity
GPY41_RS01925	COG3842	ATPase activity
GPY41_RS01930	COG1609	Transcriptional regulator
GPY41_RS01940	COG0747	negative chemotaxis
GPY41_RS01950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY41_RS01955	COG0444	Belongs to the ABC transporter superfamily
GPY41_RS01960	COG4608	Belongs to the ABC transporter superfamily
GPY41_RS01970	COG1609	Transcriptional regulator
GPY41_RS01985	COG4580	involved in the transport of maltose and maltodextrins
GPY41_RS02000	COG0534	Mate efflux family protein
GPY41_RS02010	COG1566	PFAM secretion protein HlyD family protein
GPY41_RS02050	COG0564	pseudouridine synthase activity
GPY41_RS02075	COG1609	Transcriptional regulator
GPY41_RS02085	COG1129	ABC transporter
GPY41_RS02095	COG3250	beta-galactosidase activity
GPY41_RS02105	COG2211	Major facilitator Superfamily
GPY41_RS02110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY41_RS02115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY41_RS02120	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY41_RS02165	COG3615	Tellurite resistance protein tehB
GPY41_RS02185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY41_RS02185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS02185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY41_RS02190	COG2207	Transcriptional regulator
GPY41_RS02200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY41_RS02205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY41_RS02220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY41_RS02230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY41_RS02235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY41_RS02235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY41_RS02235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS02250	COG3383	formate dehydrogenase (NAD+) activity
GPY41_RS02260	COG0583	DNA-binding transcription factor activity
GPY41_RS02265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY41_RS02270	COG0583	DNA-binding transcription factor activity
GPY41_RS02295	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY41_RS02310	COG0583	DNA-binding transcription factor activity
GPY41_RS02315	COG1733	regulation of RNA biosynthetic process
GPY41_RS02335	COG0137	argininosuccinate synthase activity
GPY41_RS02345	COG1301	dicarboxylic acid transport
GPY41_RS02390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY41_RS02395	COG2175	clavaminate synthase activity
GPY41_RS02430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY41_RS02440	COG3706	GGDEF domain
GPY41_RS02455	COG2356	endonuclease I
GPY41_RS02470	COG1368	sulfuric ester hydrolase activity
GPY41_RS02475	COG2194	sulfuric ester hydrolase activity
GPY41_RS02480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY41_RS02485	COG2205	protein histidine kinase activity
GPY41_RS02490	COG0745	RESPONSE REGULATOR receiver
GPY41_RS02505	COG4221	oxidoreductase activity
GPY41_RS02530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY41_RS02535	COG0076	glutamate decarboxylase activity
GPY41_RS02550	COG0561	phosphatase activity
GPY41_RS02565	COG0671	phosphoesterase, PA-phosphatase related
GPY41_RS02640	COG2814	Major facilitator Superfamily
GPY41_RS02660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY41_RS02665	COG4771	TonB-dependent receptor
GPY41_RS02685	COG0393	Putative heavy-metal-binding
GPY41_RS02710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY41_RS02730	COG0753	catalase activity
GPY41_RS02745	COG0346	lactoylglutathione lyase activity
GPY41_RS02755	COG2211	Major facilitator Superfamily
GPY41_RS02770	COG3240	lipase activity
GPY41_RS02850	COG3040	lipid binding
GPY41_RS02880	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GPY41_RS02890	COG2197	response regulator
GPY41_RS02910	COG2205	protein histidine kinase activity
GPY41_RS02910	COG0784	Response regulator, receiver
GPY41_RS02915	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY41_RS02925	COG2274	protein secretion by the type I secretion system
GPY41_RS02935	COG1538	Outer membrane efflux protein
GPY41_RS02955	COG0668	transmembrane transport
GPY41_RS02980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY41_RS02985	COG0793	Belongs to the peptidase S41A family
GPY41_RS02985	COG4946	Tricorn protease homolog
GPY41_RS03000	COG1122	ATPase activity
GPY41_RS03005	COG4720	Psort location CytoplasmicMembrane, score
GPY41_RS03010	COG1566	PFAM secretion protein HlyD family protein
GPY41_RS03020	COG3706	GGDEF domain
GPY41_RS03040	COG3272	Protein of unknown function (DUF1722)
GPY41_RS03045	COG0789	Transcriptional regulator
GPY41_RS03050	COG0415	Belongs to the DNA photolyase family
GPY41_RS03055	COG1376	ErfK ybiS ycfS ynhG family protein
GPY41_RS03055	COG1388	LysM domain
GPY41_RS03065	COG0513	Belongs to the DEAD box helicase family
GPY41_RS03105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY41_RS03110	COG0573	inorganic phosphate transmembrane transporter activity
GPY41_RS03115	COG0581	inorganic phosphate transmembrane transporter activity
GPY41_RS03120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY41_RS03125	COG3706	GGDEF domain
GPY41_RS03125	COG2203	Gaf domain
GPY41_RS03125	COG4251	negative regulation of phosphorylation
GPY41_RS03125	COG5001	Diguanylate cyclase
GPY41_RS03135	COG2304	oxidoreductase activity
GPY41_RS03155	COG0714	Associated with various cellular activities
GPY41_RS03225	COG1596	polysaccharide export
GPY41_RS03235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY41_RS03285	COG2354	Protein conserved in bacteria
GPY41_RS03295	COG0418	dihydroorotase activity
GPY41_RS03300	COG0633	Ferredoxin
GPY41_RS03300	COG3217	Mosc domain protein beta barrel domain protein
GPY41_RS03300	COG0633	Ferredoxin
GPY41_RS03300	COG3217	Mosc domain protein beta barrel domain protein
GPY41_RS03305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY41_RS03355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY41_RS03365	COG0848	biopolymer transport protein
GPY41_RS03370	COG0811	peptide transport
GPY41_RS03375	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY41_RS03385	COG3721	Heme iron utilization protein
GPY41_RS03390	COG0748	coenzyme F420 binding
GPY41_RS03400	COG0835	chemotaxis
GPY41_RS03400	COG0784	Response regulator, receiver
GPY41_RS03405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY41_RS03415	COG0589	response to stress
GPY41_RS03455	COG0366	Alpha amylase catalytic
GPY41_RS03465	COG0840	transmembrane signaling receptor activity
GPY41_RS03500	COG0739	heme binding
GPY41_RS03505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY41_RS03520	COG2084	Dehydrogenase
GPY41_RS03545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY41_RS03565	COG0840	transmembrane signaling receptor activity
GPY41_RS03580	COG3706	GGDEF domain
GPY41_RS03585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY41_RS03585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY41_RS03590	COG1765	OsmC-like protein
GPY41_RS03680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY41_RS03750	COG1765	OsmC-like protein
GPY41_RS03755	COG2171	N-acyltransferase activity
GPY41_RS03775	COG1011	Hydrolase
GPY41_RS03800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY41_RS03805	COG2207	Transcriptional regulator
GPY41_RS03805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY41_RS03820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY41_RS03825	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY41_RS03850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY41_RS03855	COG0583	DNA-binding transcription factor activity
GPY41_RS03865	COG1228	amidohydrolase
GPY41_RS03905	COG1760	l-serine dehydratase
GPY41_RS03925	COG1686	Belongs to the peptidase S11 family
GPY41_RS03945	COG1309	transcriptional regulator
GPY41_RS03950	COG1012	belongs to the aldehyde dehydrogenase family
GPY41_RS03970	COG4175	Glycine betaine
GPY41_RS03975	COG3059	membrane
GPY41_RS04010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY41_RS04015	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY41_RS04020	COG0247	lactate metabolic process
GPY41_RS04035	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPY41_RS04040	COG2133	pyrroloquinoline quinone binding
GPY41_RS04050	COG1454	alcohol dehydrogenase
GPY41_RS04055	COG0443	Heat shock 70 kDa protein
GPY41_RS04060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY41_RS04090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY41_RS04095	COG3174	membrane
GPY41_RS04120	COG0814	amino acid
GPY41_RS04125	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY41_RS04150	COG2962	Rard protein
GPY41_RS04165	COG0671	phosphoesterase, PA-phosphatase related
GPY41_RS04175	COG1288	antiporter activity
GPY41_RS04190	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY41_RS04205	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY41_RS04210	COG2315	Protein conserved in bacteria
GPY41_RS04230	COG1129	ABC transporter
GPY41_RS04235	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY41_RS04240	COG1879	ABC-type sugar transport system periplasmic component
GPY41_RS04245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY41_RS04250	COG1609	Transcriptional regulator
GPY41_RS04260	COG0784	Response regulator, receiver
GPY41_RS04260	COG0835	chemotaxis
GPY41_RS04270	COG0456	acetyltransferase
GPY41_RS04285	COG1366	Belongs to the anti-sigma-factor antagonist family
GPY41_RS04295	COG2172	sigma factor antagonist activity
GPY41_RS04310	COG3437	response regulator, receiver
GPY41_RS04315	COG0420	3'-5' exonuclease activity
GPY41_RS04320	COG0419	ATPase involved in DNA repair
GPY41_RS04330	COG0583	DNA-binding transcription factor activity
GPY41_RS04350	COG4964	Belongs to the GSP D family
GPY41_RS04435	COG0471	metal ion transport
GPY41_RS04440	COG3290	protein histidine kinase activity
GPY41_RS04450	COG0110	maltose O-acetyltransferase activity
GPY41_RS04470	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY41_RS04475	COG4605	iron ion homeostasis
GPY41_RS04480	COG4604	ABC transporter, ATP-binding protein
GPY41_RS04485	COG0789	Transcriptional regulator
GPY41_RS04530	COG1289	transmembrane transporter activity
GPY41_RS04535	COG0210	DNA helicase
GPY41_RS04545	COG1879	ABC-type sugar transport system periplasmic component
GPY41_RS04570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPY41_RS04575	COG3005	denitrification pathway
GPY41_RS04600	COG0513	Belongs to the DEAD box helicase family
GPY41_RS04610	COG1716	ATPase activity
GPY41_RS04610	COG5001	Diguanylate cyclase
GPY41_RS04635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY41_RS04650	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY41_RS04655	COG0513	Belongs to the DEAD box helicase family
GPY41_RS04665	COG3119	arylsulfatase activity
GPY41_RS04705	COG2814	Major facilitator Superfamily
GPY41_RS04725	COG0583	DNA-binding transcription factor activity
GPY41_RS04730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY41_RS04745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY41_RS04760	COG1132	(ABC) transporter
GPY41_RS04770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY41_RS04770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY41_RS04780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY41_RS04825	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY41_RS04825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY41_RS04825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY41_RS04830	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY41_RS04835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS04835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS04840	COG1609	Transcriptional regulator
GPY41_RS04865	COG0469	pyruvate kinase activity
GPY41_RS04870	COG2271	Major facilitator Superfamily
GPY41_RS04875	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY41_RS04880	COG4191	Histidine kinase
GPY41_RS04890	COG1979	alcohol dehydrogenase
GPY41_RS04895	COG2207	Transcriptional regulator
GPY41_RS04915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY41_RS04930	COG0784	Response regulator, receiver
GPY41_RS04930	COG3437	response regulator, receiver
GPY41_RS04935	COG0546	phosphoglycolate phosphatase activity
GPY41_RS04950	COG0513	Belongs to the DEAD box helicase family
GPY41_RS04965	COG3038	cytochrome b561
GPY41_RS04980	COG0583	DNA-binding transcription factor activity
GPY41_RS04990	COG3593	DNA synthesis involved in DNA repair
GPY41_RS04995	COG0737	Belongs to the 5'-nucleotidase family
GPY41_RS05000	COG0861	Integral membrane protein TerC family
GPY41_RS05015	COG0010	Belongs to the arginase family
GPY41_RS05030	COG2267	carboxylic ester hydrolase activity
GPY41_RS05035	COG2067	long-chain fatty acid transport protein
GPY41_RS05050	COG2050	protein possibly involved in aromatic compounds catabolism
GPY41_RS05060	COG4533	DNA binding
GPY41_RS05070	COG0366	Alpha amylase catalytic
GPY41_RS05075	COG0583	DNA-binding transcription factor activity
GPY41_RS05095	COG0484	heat shock protein binding
GPY41_RS05110	COG1716	ATPase activity
GPY41_RS05110	COG5001	Diguanylate cyclase
GPY41_RS05115	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY41_RS05125	COG4181	ATPase activity
GPY41_RS05130	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY41_RS05135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY41_RS05135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY41_RS05140	COG1984	allophanate hydrolase subunit 2
GPY41_RS05145	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY41_RS05150	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY41_RS05160	COG5002	protein histidine kinase activity
GPY41_RS05160	COG3447	MASE1 domain protein
GPY41_RS05160	COG5001	Diguanylate cyclase
GPY41_RS05170	COG0583	DNA-binding transcription factor activity
GPY41_RS05175	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY41_RS05175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY41_RS05175	COG1042	CoA-binding domain protein
GPY41_RS05185	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY41_RS05195	COG0023	Translation Initiation Factor
GPY41_RS05200	COG3140	Belongs to the UPF0181 family
GPY41_RS05215	COG0745	RESPONSE REGULATOR receiver
GPY41_RS05225	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY41_RS05230	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY41_RS05245	COG3706	GGDEF domain
GPY41_RS05255	COG0745	RESPONSE REGULATOR receiver
GPY41_RS05265	COG1846	Transcriptional regulator
GPY41_RS05270	COG0697	spore germination
GPY41_RS05280	COG4149	molybdate abc transporter
GPY41_RS05285	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY41_RS05305	COG4067	protein conserved in archaea
GPY41_RS05305	COG0189	ligase activity
GPY41_RS05315	COG0840	transmembrane signaling receptor activity
GPY41_RS05320	COG0602	queuosine metabolic process
GPY41_RS05325	COG1328	CTP reductase activity
GPY41_RS05380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY41_RS05385	COG3118	belongs to the thioredoxin family
GPY41_RS05400	COG0534	Mate efflux family protein
GPY41_RS05420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY41_RS05435	COG0848	biopolymer transport protein
GPY41_RS05440	COG0811	peptide transport
GPY41_RS05445	COG0811	peptide transport
GPY41_RS05475	COG2146	nitrite reductase [NAD(P)H] activity
GPY41_RS05480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY41_RS05485	COG0840	transmembrane signaling receptor activity
GPY41_RS05525	COG5001	Diguanylate cyclase
GPY41_RS05525	COG3706	GGDEF domain
GPY41_RS05525	COG2203	Gaf domain
GPY41_RS05525	COG4251	negative regulation of phosphorylation
GPY41_RS05535	COG0010	Belongs to the arginase family
GPY41_RS05540	COG0513	Belongs to the DEAD box helicase family
GPY41_RS05550	COG0523	cobalamin synthesis protein
GPY41_RS05560	COG2199	diguanylate cyclase activity
GPY41_RS05575	COG2146	nitrite reductase [NAD(P)H] activity
GPY41_RS05575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY41_RS05580	COG1116	anion transmembrane transporter activity
GPY41_RS05585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY41_RS05590	COG1116	anion transmembrane transporter activity
GPY41_RS05590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY41_RS05595	COG3707	response regulator
GPY41_RS05610	COG1648	precorrin-2 dehydrogenase activity
GPY41_RS05610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY41_RS05615	COG0243	molybdopterin cofactor binding
GPY41_RS05625	COG0366	Alpha amylase catalytic
GPY41_RS05630	COG0840	transmembrane signaling receptor activity
GPY41_RS05635	COG0840	transmembrane signaling receptor activity
GPY41_RS05650	COG2271	Major facilitator Superfamily
GPY41_RS05655	COG0584	glycerophosphoryl diester phosphodiesterase
GPY41_RS05660	COG0312	modulator of DNA gyrase
GPY41_RS05665	COG0312	modulator of DNA gyrase
GPY41_RS05675	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY41_RS05685	COG0501	Belongs to the peptidase M48B family
GPY41_RS05705	COG3209	COG3209 Rhs family protein
GPY41_RS05720	COG3501	Rhs element vgr protein
GPY41_RS05775	COG0631	protein serine/threonine phosphatase activity
GPY41_RS05810	COG0515	serine threonine protein kinase
GPY41_RS05810	COG2815	serine threonine protein kinase
GPY41_RS05830	COG3530	Putative quorum-sensing-regulated virulence factor
GPY41_RS05855	COG3186	Phenylalanine-4-hydroxylase
GPY41_RS05860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY41_RS05885	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY41_RS05895	COG4191	Histidine kinase
GPY41_RS05895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY41_RS05900	COG3437	response regulator, receiver
GPY41_RS05900	COG0784	Response regulator, receiver
GPY41_RS05955	COG3064	Membrane
GPY41_RS05955	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GPY41_RS05955	COG1073	alpha beta
GPY41_RS05960	COG2994	toxin metabolic process
GPY41_RS05990	COG1028	Short-chain dehydrogenase reductase Sdr
GPY41_RS06000	COG1024	Enoyl-CoA hydratase
GPY41_RS06005	COG1024	Enoyl-CoA hydratase
GPY41_RS06010	COG1960	acyl-CoA dehydrogenase activity
GPY41_RS06020	COG0183	Belongs to the thiolase family
GPY41_RS06030	COG1960	acyl-CoA dehydrogenase activity
GPY41_RS06035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY41_RS06040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY41_RS06050	COG0450	alkyl hydroperoxide reductase
GPY41_RS06060	COG1278	Cold shock
GPY41_RS06075	COG1309	transcriptional regulator
GPY41_RS06080	COG2130	NADP-dependent
GPY41_RS06085	COG0625	glutathione transferase activity
GPY41_RS06105	COG2197	response regulator
GPY41_RS06110	COG3851	Histidine kinase
GPY41_RS06115	COG2271	Major facilitator Superfamily
GPY41_RS06120	COG1482	cell wall glycoprotein biosynthetic process
GPY41_RS06130	COG2203	Gaf domain
GPY41_RS06130	COG2199	diguanylate cyclase activity
GPY41_RS06140	COG3036	rescue of stalled ribosome
GPY41_RS06145	COG1278	Cold shock
GPY41_RS06175	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY41_RS06180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY41_RS06185	COG0840	transmembrane signaling receptor activity
GPY41_RS06205	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY41_RS06215	COG4989	oxidoreductase activity
GPY41_RS06245	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY41_RS06255	COG0303	'Molybdopterin
GPY41_RS06260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY41_RS06270	COG2897	thiosulfate sulfurtransferase activity
GPY41_RS06290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY41_RS06315	COG0840	transmembrane signaling receptor activity
GPY41_RS06320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY41_RS06325	COG2885	chlorophyll binding
GPY41_RS06330	COG0109	protoheme IX farnesyltransferase activity
GPY41_RS06335	COG1612	heme a metabolic process
GPY41_RS06360	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY41_RS06365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY41_RS06370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY41_RS06375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY41_RS06385	COG1280	lysine exporter protein (LysE YggA)
GPY41_RS06410	COG1846	Transcriptional regulator
GPY41_RS06415	COG1764	response to oxidative stress
GPY41_RS06425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY41_RS06440	COG0697	spore germination
GPY41_RS06455	COG2814	Major facilitator Superfamily
GPY41_RS06460	COG0583	DNA-binding transcription factor activity
GPY41_RS06465	COG5001	Diguanylate cyclase
GPY41_RS06465	COG2203	Gaf domain
GPY41_RS06465	COG4251	negative regulation of phosphorylation
GPY41_RS06465	COG3706	GGDEF domain
GPY41_RS06470	COG0251	oxidation-reduction process
GPY41_RS06485	COG4145	pantothenate transmembrane transporter activity
GPY41_RS06495	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GPY41_RS06505	COG0837	glucose binding
GPY41_RS06505	COG1737	Transcriptional regulator
GPY41_RS06515	COG1131	(ABC) transporter
GPY41_RS06520	COG0842	Transport permease protein
GPY41_RS06555	COG1846	Transcriptional regulator
GPY41_RS06570	COG0513	Belongs to the DEAD box helicase family
GPY41_RS06595	COG3568	Endonuclease Exonuclease Phosphatase
GPY41_RS06610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY41_RS06645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY41_RS06645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY41_RS06665	COG2197	response regulator
GPY41_RS06670	COG3850	Histidine kinase
GPY41_RS06675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY41_RS06685	COG0243	molybdopterin cofactor binding
GPY41_RS06695	COG3005	denitrification pathway
GPY41_RS06705	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY41_RS06710	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY41_RS06715	COG1737	Transcriptional regulator
GPY41_RS06720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY41_RS06725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY41_RS06730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY41_RS06735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY41_RS06745	COG1940	carbohydrate kinase activity
GPY41_RS06750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY41_RS06770	COG0183	Belongs to the thiolase family
GPY41_RS06780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY41_RS06785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY41_RS06835	COG2827	Endonuclease containing a URI domain
GPY41_RS06860	COG0784	Response regulator, receiver
GPY41_RS06860	COG5002	protein histidine kinase activity
GPY41_RS06860	COG2205	protein histidine kinase activity
GPY41_RS06885	COG0583	DNA-binding transcription factor activity
GPY41_RS06900	COG1280	lysine exporter protein (LysE YggA)
GPY41_RS06910	COG1522	sequence-specific DNA binding
GPY41_RS06915	COG0531	amino acid
GPY41_RS06920	COG0121	glutamine amidotransferase
GPY41_RS06935	COG2205	protein histidine kinase activity
GPY41_RS06940	COG0745	RESPONSE REGULATOR receiver
GPY41_RS06965	COG2239	Acts as a magnesium transporter
GPY41_RS06975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY41_RS06980	COG0402	S-adenosylhomocysteine deaminase activity
GPY41_RS06985	COG1067	ATP-dependent peptidase activity
GPY41_RS06995	COG4172	Belongs to the ABC transporter superfamily
GPY41_RS07000	COG1505	serine-type exopeptidase activity
GPY41_RS07005	COG0583	DNA-binding transcription factor activity
GPY41_RS07010	COG1620	l-lactate permease
GPY41_RS07020	COG1139	Iron-sulfur cluster binding protein
GPY41_RS07045	COG2814	Major facilitator Superfamily
GPY41_RS07085	COG3706	GGDEF domain
GPY41_RS07085	COG4251	negative regulation of phosphorylation
GPY41_RS07085	COG5001	Diguanylate cyclase
GPY41_RS07085	COG2203	Gaf domain
GPY41_RS07100	COG3015	lipoprotein NlpE involved in copper resistance
GPY41_RS07105	COG1126	abc transporter atp-binding protein
GPY41_RS07110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY41_RS07115	COG4215	(ABC) transporter
GPY41_RS07120	COG4160	amino acid transport
GPY41_RS07135	COG5002	protein histidine kinase activity
GPY41_RS07135	COG5001	Diguanylate cyclase
GPY41_RS07140	COG2755	lipolytic protein G-D-S-L family
GPY41_RS07150	COG0840	transmembrane signaling receptor activity
GPY41_RS07155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY41_RS07185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY41_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
GPY41_RS07195	COG1169	isochorismate synthase
GPY41_RS07200	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY41_RS07220	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY41_RS07230	COG4607	ABC-type enterochelin transport system periplasmic component
GPY41_RS07235	COG1629	transport
GPY41_RS07235	COG4774	siderophore transport
GPY41_RS07250	COG0189	ligase activity
GPY41_RS07250	COG4067	protein conserved in archaea
GPY41_RS07275	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY41_RS07295	COG0814	amino acid
GPY41_RS07300	COG0488	(ABC) transporter
GPY41_RS07315	COG1609	Transcriptional regulator
GPY41_RS07320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS07335	COG0242	peptide deformylase activity
GPY41_RS07345	COG0488	(ABC) transporter
GPY41_RS07360	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY41_RS07365	COG1605	Chorismate mutase
GPY41_RS07365	COG0077	Prephenate dehydratase
GPY41_RS07370	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY41_RS07375	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY41_RS07430	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY41_RS07445	COG0745	RESPONSE REGULATOR receiver
GPY41_RS07450	COG5002	protein histidine kinase activity
GPY41_RS07460	COG0248	Ppx GppA phosphatase
GPY41_RS07470	COG0573	inorganic phosphate transmembrane transporter activity
GPY41_RS07475	COG0581	inorganic phosphate transmembrane transporter activity
GPY41_RS07485	COG0704	Plays a role in the regulation of phosphate uptake
GPY41_RS07510	COG0450	alkyl hydroperoxide reductase
GPY41_RS07515	COG0583	DNA-binding transcription factor activity
GPY41_RS07520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY41_RS07530	COG0517	IMP dehydrogenase activity
GPY41_RS07540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY41_RS07550	COG1862	Preprotein translocase
GPY41_RS07555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY41_RS07560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY41_RS07575	COG0483	inositol monophosphate 1-phosphatase activity
GPY41_RS07580	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY41_RS07595	COG0822	iron-sulfur transferase activity
GPY41_RS07610	COG0443	Heat shock 70 kDa protein
GPY41_RS07615	COG0633	Ferredoxin
GPY41_RS07620	COG2975	iron-sulfur cluster assembly
GPY41_RS07640	COG1426	Protein conserved in bacteria
GPY41_RS07655	COG2976	Protein conserved in bacteria
GPY41_RS07660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY41_RS07675	COG2199	diguanylate cyclase activity
GPY41_RS07675	COG2203	Gaf domain
GPY41_RS07685	COG1570	exodeoxyribonuclease VII activity
GPY41_RS07690	COG0517	IMP dehydrogenase activity
GPY41_RS07690	COG0516	GMP reductase activity
GPY41_RS07695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY41_RS07695	COG0519	Catalyzes the synthesis of GMP from XMP
GPY41_RS07700	COG0582	viral genome integration into host DNA
GPY41_RS07770	COG1196	nuclear chromosome segregation
GPY41_RS07775	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
GPY41_RS07785	COG1584	GPR1 FUN34 yaaH family protein
GPY41_RS07790	COG1115	amino acid carrier protein
GPY41_RS07795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY41_RS07800	COG0583	DNA-binding transcription factor activity
GPY41_RS07815	COG0009	L-threonylcarbamoyladenylate synthase
GPY41_RS07870	COG2867	negative regulation of translational initiation
GPY41_RS07880	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY41_RS07885	COG0497	DNA recombination
GPY41_RS07890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY41_RS07895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY41_RS07940	COG4969	Belongs to the N-Me-Phe pilin family
GPY41_RS07960	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY41_RS07965	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GPY41_RS07970	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY41_RS07975	COG0583	DNA-binding transcription factor activity
GPY41_RS07980	COG0590	tRNA wobble adenosine to inosine editing
GPY41_RS08020	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY41_RS08025	COG2252	PERMEase
GPY41_RS08055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY41_RS08060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY41_RS08060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY41_RS08085	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY41_RS08090	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY41_RS08095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY41_RS08100	COG0142	geranyltranstransferase activity
GPY41_RS08110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY41_RS08125	COG0583	DNA-binding transcription factor activity
GPY41_RS08135	COG2363	Small membrane protein
GPY41_RS08150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY41_RS08155	COG1611	Belongs to the LOG family
GPY41_RS08160	COG3706	GGDEF domain
GPY41_RS08180	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY41_RS08185	COG1464	Belongs to the NlpA lipoprotein family
GPY41_RS08190	COG2011	ABC-type metal ion transport system permease component
GPY41_RS08195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY41_RS08200	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY41_RS08210	COG1263	PTS System
GPY41_RS08210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY41_RS08215	COG0366	Alpha amylase catalytic
GPY41_RS08240	COG0321	lipoyl(octanoyl) transferase activity
GPY41_RS08250	COG1686	Belongs to the peptidase S11 family
GPY41_RS08255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY41_RS08260	COG0772	Belongs to the SEDS family
GPY41_RS08265	COG0768	penicillin binding
GPY41_RS08275	COG0799	negative regulation of ribosome biogenesis
GPY41_RS08280	COG1466	dna polymerase III delta subunit
GPY41_RS08285	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY41_RS08295	COG2888	peptidyl-tyrosine sulfation
GPY41_RS08305	COG4535	Mg2 and Co2 transporter CorC
GPY41_RS08310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY41_RS08315	COG1702	phosphate starvation-inducible protein PhoH
GPY41_RS08320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY41_RS08325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY41_RS08420	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY41_RS08430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY41_RS08440	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY41_RS08445	COG3094	Invasion gene expression up-regulator, SirB
GPY41_RS08450	COG2912	Transglutaminase-like superfamily
GPY41_RS08470	COG1187	pseudouridine synthase activity
GPY41_RS08475	COG2840	Smr protein MutS2
GPY41_RS08490	COG3735	TraB family
GPY41_RS08505	COG2608	mercury ion transmembrane transporter activity
GPY41_RS08505	COG2217	Heavy metal translocating P-type atpase
GPY41_RS08565	COG0784	Response regulator, receiver
GPY41_RS08565	COG0835	chemotaxis
GPY41_RS08570	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY41_RS08575	COG1815	bacterial-type flagellum-dependent cell motility
GPY41_RS08580	COG1558	bacterial-type flagellum-dependent cell motility
GPY41_RS08585	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY41_RS08590	COG1749	Flagellar hook protein flgE
GPY41_RS08595	COG4787	bacterial-type flagellum-dependent cell motility
GPY41_RS08600	COG4786	Flagellar basal body rod
GPY41_RS08615	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY41_RS08615	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY41_RS08625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY41_RS08630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY41_RS08635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY41_RS08640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY41_RS08645	COG2190	(PTS) system
GPY41_RS08650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY41_RS08655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS08660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY41_RS08665	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY41_RS08695	COG0330	HflC and HflK could
GPY41_RS08700	COG3118	belongs to the thioredoxin family
GPY41_RS08710	COG0300	oxidoreductase activity
GPY41_RS08715	COG1090	epimerase
GPY41_RS08740	COG0622	Phosphoesterase
GPY41_RS08760	COG3710	Transcriptional regulator
GPY41_RS08765	COG0326	Molecular chaperone. Has ATPase activity
GPY41_RS08775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY41_RS08780	COG0840	transmembrane signaling receptor activity
GPY41_RS08785	COG3104	oligopeptide transport
GPY41_RS08795	COG0367	asparagine synthase
GPY41_RS08800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY41_RS08800	COG4651	solute:proton antiporter activity
GPY41_RS08805	COG1940	carbohydrate kinase activity
GPY41_RS08805	COG1846	Transcriptional regulator
GPY41_RS08810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY41_RS08815	COG2190	(PTS) system
GPY41_RS08815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY41_RS08815	COG1263	PTS System
GPY41_RS08820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY41_RS08835	COG0716	FMN binding
GPY41_RS08845	COG0596	Alpha beta hydrolase
GPY41_RS08850	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY41_RS08855	COG0033	Phosphoglucomutase
GPY41_RS08860	COG2964	Protein conserved in bacteria
GPY41_RS08865	COG0251	oxidation-reduction process
GPY41_RS08875	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY41_RS08885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY41_RS08895	COG2009	succinate dehydrogenase
GPY41_RS08900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY41_RS08905	COG1053	succinate dehydrogenase
GPY41_RS08915	COG0567	Dehydrogenase, E1 component
GPY41_RS08920	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY41_RS08935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY41_RS08955	COG1918	ferrous iron import across plasma membrane
GPY41_RS08960	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GPY41_RS08980	COG3102	Protein conserved in bacteria
GPY41_RS08985	COG0788	formyltetrahydrofolate deformylase activity
GPY41_RS08995	COG1199	ATP-dependent helicase activity
GPY41_RS09000	COG1214	PFAM Peptidase M22, glycoprotease
GPY41_RS09015	COG0596	Alpha beta hydrolase
GPY41_RS09020	COG0318	PFAM AMP-dependent synthetase and ligase
GPY41_RS09025	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY41_RS09035	COG2894	cell division
GPY41_RS09050	COG2951	lytic endotransglycosylase activity
GPY41_RS09060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY41_RS09070	COG0745	RESPONSE REGULATOR receiver
GPY41_RS09075	COG5002	protein histidine kinase activity
GPY41_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
GPY41_RS09100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY41_RS09125	COG2986	histidine ammonia-lyase
GPY41_RS09130	COG1216	Glycosyl transferase, family 2
GPY41_RS09150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY41_RS09155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY41_RS09200	COG0745	RESPONSE REGULATOR receiver
GPY41_RS09225	COG3842	ATPase activity
GPY41_RS09230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY41_RS09235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY41_RS09240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY41_RS09250	COG2204	response regulator
GPY41_RS09255	COG4191	Histidine kinase
GPY41_RS09260	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY41_RS09275	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY41_RS09280	COG0776	regulation of translation
GPY41_RS09285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY41_RS09290	COG1555	photosystem II stabilization
GPY41_RS09310	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY41_RS09315	COG0436	Aminotransferase
GPY41_RS09320	COG1169	isochorismate synthase
GPY41_RS09330	COG0596	Alpha beta hydrolase
GPY41_RS09335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY41_RS09340	COG1441	menaquinone biosynthetic process
GPY41_RS09345	COG0318	PFAM AMP-dependent synthetase and ligase
GPY41_RS09400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY41_RS09415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY41_RS09420	COG1522	sequence-specific DNA binding
GPY41_RS09430	COG1946	Acyl-CoA thioesterase
GPY41_RS09435	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY41_RS09485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY41_RS09500	COG3139	Protein of unknown function (DUF1315)
GPY41_RS09505	COG0252	asparaginase activity
GPY41_RS09510	COG0616	signal peptide processing
GPY41_RS09515	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY41_RS09515	COG1902	pentaerythritol trinitrate reductase activity
GPY41_RS09520	COG0778	Nitroreductase
GPY41_RS09525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY41_RS09530	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY41_RS09540	COG0745	RESPONSE REGULATOR receiver
GPY41_RS09540	COG3706	GGDEF domain
GPY41_RS09550	COG2731	YhcH YjgK YiaL family protein
GPY41_RS09555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY41_RS09560	COG0569	domain protein
GPY41_RS09570	COG3083	sulfuric ester hydrolase activity
GPY41_RS09575	COG3082	Protein of unknown function (DUF1414)
GPY41_RS09580	COG3081	Nucleoid-associated protein
GPY41_RS09595	COG1757	Na H antiporter
GPY41_RS09600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY41_RS09610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY41_RS09615	COG2095	MarC family integral membrane protein
GPY41_RS09620	COG1454	alcohol dehydrogenase
GPY41_RS09620	COG1012	belongs to the aldehyde dehydrogenase family
GPY41_RS09625	COG1028	Short-chain dehydrogenase reductase Sdr
GPY41_RS09640	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY41_RS09650	COG2056	Na+-H+ antiporter family
GPY41_RS09655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY41_RS09660	COG2885	chlorophyll binding
GPY41_RS09670	COG0346	lactoylglutathione lyase activity
GPY41_RS09675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY41_RS09685	COG4659	FMN binding
GPY41_RS09695	COG4656	Part of a membrane complex involved in electron transport
GPY41_RS09735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY41_RS09745	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY41_RS09750	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY41_RS09755	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY41_RS09760	COG0314	molybdopterin synthase activity
GPY41_RS09770	COG0601	transmembrane transport
GPY41_RS09775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY41_RS09780	COG0444	Belongs to the ABC transporter superfamily
GPY41_RS09790	COG0435	Glutathione S-transferase
GPY41_RS09800	COG2350	Protein conserved in bacteria
GPY41_RS09805	COG1607	acyl-coa hydrolase
GPY41_RS09820	COG1301	dicarboxylic acid transport
GPY41_RS09835	COG0135	phosphoribosylanthranilate isomerase activity
GPY41_RS09835	COG0134	indole-3-glycerol-phosphate synthase activity
GPY41_RS09840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY41_RS09845	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY41_RS09850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY41_RS09865	COG0009	L-threonylcarbamoyladenylate synthase
GPY41_RS09895	COG5001	Diguanylate cyclase
GPY41_RS09900	COG0417	DNA replication proofreading
GPY41_RS09905	COG2197	response regulator
GPY41_RS09975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY41_RS09980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY41_RS10010	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY41_RS10015	COG0437	4 iron, 4 sulfur cluster binding
GPY41_RS10020	COG3301	Polysulphide reductase, NrfD
GPY41_RS10025	COG1138	Cytochrome C-type biogenesis protein
GPY41_RS10035	COG3088	subunit of a heme lyase
GPY41_RS10045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY41_RS10045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY41_RS10065	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY41_RS10070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY41_RS10075	COG0659	secondary active sulfate transmembrane transporter activity
GPY41_RS10080	COG1530	ribonuclease E activity
GPY41_RS10095	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY41_RS10110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY41_RS10140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY41_RS10160	COG1263	PTS System
GPY41_RS10160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY41_RS10175	COG0733	neurotransmitter:sodium symporter activity
GPY41_RS10190	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY41_RS10195	COG0469	pyruvate kinase activity
GPY41_RS10200	COG1940	carbohydrate kinase activity
GPY41_RS10205	COG0835	chemotaxis
GPY41_RS10205	COG0784	Response regulator, receiver
GPY41_RS10210	COG0587	DNA-directed DNA polymerase activity
GPY41_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
GPY41_RS10230	COG0616	signal peptide processing
GPY41_RS10240	COG0539	negative regulation of cytoplasmic translation
GPY41_RS10250	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY41_RS10255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY41_RS10260	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY41_RS10265	COG4174	ABC transporter (Permease)
GPY41_RS10270	COG4239	(ABC) transporter, permease
GPY41_RS10275	COG4166	transmembrane transport
GPY41_RS10280	COG0444	Belongs to the ABC transporter superfamily
GPY41_RS10285	COG4608	Belongs to the ABC transporter superfamily
GPY41_RS10310	COG0583	DNA-binding transcription factor activity
GPY41_RS10320	COG0686	Belongs to the AlaDH PNT family
GPY41_RS10340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY41_RS10375	COG0501	Belongs to the peptidase M48B family
GPY41_RS10385	COG1028	Short-chain dehydrogenase reductase Sdr
GPY41_RS10400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY41_RS10420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY41_RS10430	COG0482	sulfurtransferase activity
GPY41_RS10440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY41_RS10445	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY41_RS10450	COG1757	Na H antiporter
GPY41_RS10460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY41_RS10465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY41_RS10470	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY41_RS10470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY41_RS10475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY41_RS10480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY41_RS10520	COG3706	GGDEF domain
GPY41_RS10560	COG0653	protein targeting
GPY41_RS10575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY41_RS10580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY41_RS10595	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY41_RS10615	COG4804	nuclease activity
GPY41_RS10645	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY41_RS10680	COG3706	GGDEF domain
GPY41_RS10680	COG0745	RESPONSE REGULATOR receiver
GPY41_RS10695	COG3012	SEC-C Motif Domain Protein
GPY41_RS10700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY41_RS10705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY41_RS10710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY41_RS10720	COG1435	thymidine kinase activity
GPY41_RS10735	COG0583	DNA-binding transcription factor activity
GPY41_RS10755	COG2116	formate transmembrane transporter activity
GPY41_RS10760	COG0390	transport system, permease component
GPY41_RS10765	COG4459	periplasmic nitrate reductase
GPY41_RS10770	COG3005	denitrification pathway
GPY41_RS10775	COG0243	molybdopterin cofactor binding
GPY41_RS10805	COG1227	inorganic diphosphatase activity
GPY41_RS10820	COG4172	Belongs to the ABC transporter superfamily
GPY41_RS10830	COG4171	peptide transport system, permease
GPY41_RS10835	COG4168	peptide transport system, permease
GPY41_RS10845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY41_RS10850	COG1842	Phage shock protein A
GPY41_RS10860	COG1983	PspC domain protein
GPY41_RS10880	COG2818	Glycosylase
GPY41_RS10885	COG0626	cystathionine gamma-synthase activity
GPY41_RS10895	COG0733	neurotransmitter:sodium symporter activity
GPY41_RS10905	COG0564	pseudouridine synthase activity
GPY41_RS10915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY41_RS10920	COG1151	hydroxylamine reductase activity
GPY41_RS10925	COG3604	Transcriptional regulator
GPY41_RS10930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY41_RS10935	COG4136	ATPase activity
GPY41_RS10940	COG4135	transport system, permease component
GPY41_RS10945	COG4134	Bacterial extracellular solute-binding protein
GPY41_RS10955	COG3313	Fe-S protein
GPY41_RS10985	COG2205	protein histidine kinase activity
GPY41_RS11000	COG1061	Type III restriction enzyme res subunit
GPY41_RS11010	COG2814	Major facilitator Superfamily
GPY41_RS11025	COG0702	epimerase
GPY41_RS11030	COG1136	(ABC) transporter
GPY41_RS11065	COG2985	domain, Protein
GPY41_RS11065	COG3273	potassium ion transport
GPY41_RS11070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY41_RS11075	COG1979	alcohol dehydrogenase
GPY41_RS11080	COG1737	Transcriptional regulator
GPY41_RS11085	COG0076	glutamate decarboxylase activity
GPY41_RS11095	COG2431	L-lysine efflux transmembrane transporter activity
GPY41_RS11105	COG3070	regulator of competence-specific genes
GPY41_RS11120	COG5002	protein histidine kinase activity
GPY41_RS11120	COG5002	protein histidine kinase activity
GPY41_RS11135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY41_RS11140	COG4988	ABC transporter
GPY41_RS11145	COG0492	ferredoxin-NADP+ reductase activity
GPY41_RS11155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY41_RS11165	COG0745	RESPONSE REGULATOR receiver
GPY41_RS11165	COG3706	GGDEF domain
GPY41_RS11170	COG0471	metal ion transport
GPY41_RS11175	COG2949	membrane
GPY41_RS11180	COG0281	malic enzyme
GPY41_RS11185	COG1643	Atp-dependent helicase
GPY41_RS11210	COG1346	cytolysis
GPY41_RS11215	COG1380	Effector of murein hydrolase LrgA
GPY41_RS11220	COG2925	Exonuclease
GPY41_RS11265	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY41_RS11295	COG1451	nucleotide metabolic process
GPY41_RS11310	COG3063	Type IV pilus biogenesis stability protein PilW
GPY41_RS11315	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY41_RS11320	COG0737	Belongs to the 5'-nucleotidase family
GPY41_RS11325	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY41_RS11335	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY41_RS11345	COG0625	glutathione transferase activity
GPY41_RS11385	COG1278	Cold shock
GPY41_RS11395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY41_RS11400	COG0584	glycerophosphoryl diester phosphodiesterase
GPY41_RS11405	COG1349	DNA-binding transcription factor activity
GPY41_RS11415	COG0395	ABC-type sugar transport system, permease component
GPY41_RS11420	COG1175	transmembrane transport
GPY41_RS11425	COG1653	transport
GPY41_RS11440	COG0730	response to heat
GPY41_RS11450	COG2197	response regulator
GPY41_RS11540	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GPY41_RS11585	COG0732	type I restriction modification DNA specificity domain
GPY41_RS11590	COG1401	restriction endodeoxyribonuclease activity
GPY41_RS11620	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY41_RS11625	COG0372	Belongs to the citrate synthase family
GPY41_RS11630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GPY41_RS11635	COG2828	Protein conserved in bacteria
GPY41_RS11665	COG0561	phosphatase activity
GPY41_RS11670	COG0602	queuosine metabolic process
GPY41_RS11675	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY41_RS11680	COG3706	GGDEF domain
GPY41_RS11705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY41_RS11715	COG1254	Belongs to the acylphosphatase family
GPY41_RS11720	COG2920	part of a sulfur-relay system
GPY41_RS11725	COG0670	Belongs to the BI1 family
GPY41_RS11730	COG1126	abc transporter atp-binding protein
GPY41_RS11735	COG0765	amino acid transport
GPY41_RS11740	COG4597	amino acid ABC transporter
GPY41_RS11745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY41_RS11755	COG0437	4 iron, 4 sulfur cluster binding
GPY41_RS11760	COG0348	domain, Protein
GPY41_RS11765	COG0204	Acyl-transferase
GPY41_RS11770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY41_RS11785	COG1115	amino acid carrier protein
GPY41_RS11810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY41_RS11825	COG3290	protein histidine kinase activity
GPY41_RS11830	COG4565	transcriptional regulatory protein
GPY41_RS11835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY41_RS11840	COG0363	glucosamine-6-phosphate deaminase activity
GPY41_RS11845	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY41_RS11880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY41_RS11885	COG1215	transferase activity, transferring glycosyl groups
GPY41_RS11890	COG0438	transferase activity, transferring glycosyl groups
GPY41_RS11935	COG2204	response regulator
GPY41_RS11965	COG1366	Belongs to the anti-sigma-factor antagonist family
GPY41_RS11970	COG1793	dna ligase
GPY41_RS11975	COG3706	GGDEF domain
GPY41_RS11985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY41_RS12000	COG2996	Protein conserved in bacteria
GPY41_RS12010	COG3008	intermembrane lipid transfer
GPY41_RS12015	COG2995	paraquat-inducible protein a
GPY41_RS12020	COG1132	(ABC) transporter
GPY41_RS12025	COG1956	GAF domain-containing protein
GPY41_RS12045	COG0308	aminopeptidase N
GPY41_RS12055	COG2902	Dehydrogenase
GPY41_RS12070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY41_RS12070	COG0116	Belongs to the methyltransferase superfamily
GPY41_RS12080	COG0488	(ABC) transporter
GPY41_RS12100	COG1067	ATP-dependent peptidase activity
GPY41_RS12105	COG3120	sequence-specific DNA binding
GPY41_RS12140	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY41_RS12155	COG2010	Cytochrome c
GPY41_RS12165	COG2217	Heavy metal translocating P-type atpase
GPY41_RS12180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY41_RS12185	COG0589	response to stress
GPY41_RS12200	COG2992	FlgJ-related protein
GPY41_RS12215	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY41_RS12220	COG1177	transmembrane transport
GPY41_RS12225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY41_RS12230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY41_RS12235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY41_RS12240	COG0004	ammonium transporteR
GPY41_RS12275	COG0437	4 iron, 4 sulfur cluster binding
GPY41_RS12280	COG3383	formate dehydrogenase (NAD+) activity
GPY41_RS12280	COG0243	molybdopterin cofactor binding
GPY41_RS12310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY41_RS12320	COG0488	(ABC) transporter
GPY41_RS12335	COG3852	Histidine kinase
GPY41_RS12340	COG2204	response regulator
GPY41_RS12350	COG4662	Binding-protein-dependent transport system inner membrane component
GPY41_RS12355	COG3842	ATPase activity
GPY41_RS12360	COG0746	molybdenum cofactor guanylyltransferase activity
GPY41_RS12390	COG0840	transmembrane signaling receptor activity
GPY41_RS12395	COG0791	NLP P60 protein
GPY41_RS12405	COG3706	GGDEF domain
GPY41_RS12425	COG0307	riboflavin synthase, alpha
GPY41_RS12430	COG0534	Mate efflux family protein
GPY41_RS12525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY41_RS12540	COG0346	lactoylglutathione lyase activity
GPY41_RS12715	COG1683	Conserved Protein
GPY41_RS13215	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPY41_RS13215	COG0456	acetyltransferase
GPY41_RS13835	COG4628	conserved protein (DUF2132)
GPY41_RS14185	COG0384	phenazine biosynthesis protein PhzF
GPY41_RS14300	COG4628	conserved protein (DUF2132)
GPY41_RS14310	COG2314	TM2 domain
GPY41_RS14430	COG2026	Addiction module toxin, RelE StbE family
GPY41_RS14510	COG2026	Addiction module toxin, RelE StbE family
GPY41_RS14570	COG4326	sporulation control protein
GPY41_RS14590	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY41_RS14605	COG5640	endopeptidase activity
GPY41_RS14610	COG2020	methyltransferase activity
GPY41_RS14615	COG0277	FAD linked oxidase domain protein
GPY41_RS14615	COG0247	lactate metabolic process
GPY41_RS14630	COG2885	chlorophyll binding
GPY41_RS14645	COG0295	cytidine deaminase activity
GPY41_RS14685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY41_RS14685	COG0072	phenylalanine-tRNA ligase activity
GPY41_RS14695	COG0745	RESPONSE REGULATOR receiver
GPY41_RS14695	COG3706	GGDEF domain
GPY41_RS14760	COG0010	Belongs to the arginase family
GPY41_RS14765	COG0840	transmembrane signaling receptor activity
GPY41_RS14780	COG2814	Major facilitator Superfamily
GPY41_RS14785	COG5380	lipid catabolic process
GPY41_RS14790	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY41_RS14815	COG1643	Atp-dependent helicase
GPY41_RS14825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY41_RS14865	COG2894	cell division
GPY41_RS14875	COG4964	Belongs to the GSP D family
GPY41_RS14905	COG3713	MltA-interacting MipA family protein
GPY41_RS14925	COG3706	GGDEF domain
GPY41_RS14935	COG0443	Heat shock 70 kDa protein
GPY41_RS14940	COG0443	Heat shock 70 kDa protein
GPY41_RS14980	COG0297	glycogen (starch) synthase activity
GPY41_RS14980	COG0438	transferase activity, transferring glycosyl groups
GPY41_RS15010	COG1596	polysaccharide export
GPY41_RS15020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY41_RS15025	COG1115	amino acid carrier protein
GPY41_RS15030	COG1132	(ABC) transporter
GPY41_RS15035	COG1132	(ABC) transporter
GPY41_RS15050	COG0783	Belongs to the Dps family
GPY41_RS15065	COG0814	amino acid
GPY41_RS15070	COG1597	lipid kinase activity
GPY41_RS15085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY41_RS15100	COG0583	DNA-binding transcription factor activity
GPY41_RS15105	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY41_RS15110	COG1328	CTP reductase activity
GPY41_RS15115	COG5001	Diguanylate cyclase
GPY41_RS15115	COG3300	MHYT domain
GPY41_RS15130	COG2199	diguanylate cyclase activity
GPY41_RS15130	COG2200	EAL domain
GPY41_RS15135	COG3706	GGDEF domain
GPY41_RS15145	COG4191	Histidine kinase
GPY41_RS15145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY41_RS15150	COG0471	metal ion transport
GPY41_RS15165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY41_RS15170	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY41_RS15175	COG3768	UPF0283 membrane protein
GPY41_RS15180	COG3106	COG3106 Predicted ATPase
GPY41_RS15195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY41_RS15210	COG0494	nUDIX hydrolase
GPY41_RS15215	COG0814	amino acid
GPY41_RS15220	COG1760	l-serine dehydratase
GPY41_RS15225	COG2200	EAL domain
GPY41_RS15235	COG0720	synthase
GPY41_RS15240	COG0840	transmembrane signaling receptor activity
GPY41_RS15260	COG2770	Histidine kinase
GPY41_RS15260	COG3437	response regulator, receiver
GPY41_RS15265	COG1448	Aminotransferase
GPY41_RS15285	COG0840	transmembrane signaling receptor activity
GPY41_RS15290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY41_RS15295	COG1846	Transcriptional regulator
GPY41_RS15320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY41_RS15335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY41_RS15340	COG3108	Peptidase M15
GPY41_RS15345	COG2989	Protein conserved in bacteria
GPY41_RS15380	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY41_RS15390	COG0653	protein targeting
GPY41_RS15400	COG3706	GGDEF domain
GPY41_RS15400	COG0745	RESPONSE REGULATOR receiver
GPY41_RS15405	COG0366	Alpha amylase catalytic
GPY41_RS15415	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY41_RS15425	COG3092	negative regulation of chromosome organization
GPY41_RS15435	COG0857	belongs to the CobB CobQ family
GPY41_RS15435	COG0280	phosphate acetyltransferase
GPY41_RS15445	COG0583	DNA-binding transcription factor activity
GPY41_RS15470	COG1032	radical SAM domain protein
GPY41_RS15490	COG2207	Transcriptional regulator
GPY41_RS15505	COG0861	Integral membrane protein TerC family
GPY41_RS15510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY41_RS15520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY41_RS15535	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPY41_RS15590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY41_RS15605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY41_RS15625	COG0494	nUDIX hydrolase
GPY41_RS15665	COG1609	Transcriptional regulator
GPY41_RS15665	COG2207	Transcriptional regulator
GPY41_RS15780	COG2199	diguanylate cyclase activity
GPY41_RS15780	COG2203	Gaf domain
GPY41_RS15790	COG2610	gluconate transmembrane transporter activity
GPY41_RS15795	COG3622	Belongs to the hyi family
GPY41_RS15800	COG0235	Class ii aldolase
GPY41_RS15805	COG3395	kinase activity
GPY41_RS15810	COG2084	Dehydrogenase
GPY41_RS15815	COG1349	DNA-binding transcription factor activity
GPY41_RS15835	COG2003	Belongs to the UPF0758 family
GPY41_RS15850	COG0328	RNA-DNA hybrid ribonuclease activity
GPY41_RS15890	COG0582	viral genome integration into host DNA
GPY41_RS15905	COG2205	protein histidine kinase activity
GPY41_RS15905	COG0784	Response regulator, receiver
GPY41_RS15915	COG0754	glutathionylspermidine amidase activity
GPY41_RS15925	COG3766	membrane
GPY41_RS15930	COG0137	argininosuccinate synthase activity
GPY41_RS15935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY41_RS15940	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY41_RS15945	COG2885	chlorophyll binding
GPY41_RS15950	COG0823	Involved in the tonB-independent uptake of proteins
GPY41_RS15965	COG0811	peptide transport
GPY41_RS15970	COG0824	Thioesterase
GPY41_RS15980	COG4890	Cyd operon protein YbgT
GPY41_RS15985	COG1294	oxidase, subunit
GPY41_RS15990	COG1271	oxidase subunit
GPY41_RS15995	COG2255	four-way junction helicase activity
GPY41_RS16005	COG0840	transmembrane signaling receptor activity
GPY41_RS16025	COG4106	trans-aconitate 2-methyltransferase activity
GPY41_RS16035	COG0189	ligase activity
GPY41_RS16035	COG4067	protein conserved in archaea
GPY41_RS16065	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY41_RS16075	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY41_RS16085	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY41_RS16090	COG0745	RESPONSE REGULATOR receiver
GPY41_RS16105	COG3070	regulator of competence-specific genes
GPY41_RS16130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY41_RS16135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY41_RS16145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY41_RS16165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY41_RS16170	COG0542	response to heat
GPY41_RS16180	COG1278	Cold shock
GPY41_RS16200	COG1199	ATP-dependent helicase activity
GPY41_RS16210	COG3923	Primosomal replication protein n
GPY41_RS16220	COG0840	transmembrane signaling receptor activity
GPY41_RS16225	COG0708	Exodeoxyribonuclease III
GPY41_RS16240	COG4215	(ABC) transporter
GPY41_RS16265	COG1882	Formate acetyltransferase
GPY41_RS16280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY41_RS16295	COG3713	MltA-interacting MipA family protein
GPY41_RS16300	COG2766	serine protein kinase
GPY41_RS16305	COG2718	Belongs to the UPF0229 family
GPY41_RS16310	COG2719	SpoVR family
GPY41_RS16320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY41_RS16330	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY41_RS16340	COG2333	competence protein COMEC
GPY41_RS16340	COG0658	competence protein
GPY41_RS16350	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY41_RS16360	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY41_RS16370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY41_RS16385	COG1252	NADH dehydrogenase
GPY41_RS16415	COG0537	adenosine 5'-monophosphoramidase activity
GPY41_RS16440	COG4109	DRTGG domain
GPY41_RS16445	COG3706	GGDEF domain
GPY41_RS16450	COG1982	Orn Lys Arg decarboxylase major
GPY41_RS16455	COG0531	amino acid
GPY41_RS16460	COG3710	Transcriptional regulator
GPY41_RS16480	COG2199	diguanylate cyclase activity
GPY41_RS16480	COG2203	Gaf domain
GPY41_RS16485	COG2239	Acts as a magnesium transporter
GPY41_RS16565	COG2226	methyltransferase
GPY41_RS16580	COG1785	Belongs to the alkaline phosphatase family
GPY41_RS16590	COG0346	lactoylglutathione lyase activity
GPY41_RS16600	COG2983	Belongs to the UPF0260 family
GPY41_RS16615	COG0745	RESPONSE REGULATOR receiver
GPY41_RS16620	COG2205	protein histidine kinase activity
GPY41_RS16660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY41_RS16675	COG2832	Protein of unknown function (DUF454)
GPY41_RS16685	COG0745	RESPONSE REGULATOR receiver
GPY41_RS16690	COG0583	DNA-binding transcription factor activity
GPY41_RS16695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY41_RS16700	COG1286	toxin biosynthetic process
GPY41_RS16705	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY41_RS16710	COG0285	dihydrofolate synthase activity
GPY41_RS16730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY41_RS16740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY41_RS16755	COG3101	peptidyl-lysine hydroxylation
GPY41_RS16760	COG2860	membrane
GPY41_RS16770	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY41_RS16775	COG2840	Smr protein MutS2
GPY41_RS16780	COG2062	phosphohistidine phosphatase, SixA
GPY41_RS16785	COG1025	Belongs to the peptidase M16 family
GPY41_RS16790	COG1024	Enoyl-CoA hydratase
GPY41_RS16790	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY41_RS16810	COG2067	long-chain fatty acid transport protein
GPY41_RS16815	COG2067	long-chain fatty acid transport protein
GPY41_RS16820	COG2853	Lipoprotein
GPY41_RS16830	COG4235	cytochrome complex assembly
GPY41_RS16830	COG3088	subunit of a heme lyase
GPY41_RS16835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY41_RS16840	COG1138	Cytochrome C-type biogenesis protein
GPY41_RS16850	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY41_RS16855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY41_RS16860	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY41_RS16865	COG4133	protoheme IX ABC transporter activity
GPY41_RS16875	COG0835	chemotaxis
GPY41_RS16885	COG1192	Involved in chromosome partitioning
GPY41_RS16895	COG2198	Histidine kinase
GPY41_RS16895	COG0643	Histidine kinase
GPY41_RS16900	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY41_RS16915	COG0455	bacterial-type flagellum organization
GPY41_RS16935	COG1684	flagellar biosynthetic protein fliR
GPY41_RS16940	COG1987	bacterial-type flagellum assembly
GPY41_RS16990	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY41_RS17000	COG1677	Flagellar hook-basal body complex protein FliE
GPY41_RS17005	COG2204	response regulator
GPY41_RS17010	COG4191	Histidine kinase
GPY41_RS17015	COG2204	response regulator
GPY41_RS17020	COG1516	flagellar protein fliS
GPY41_RS17030	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY41_RS17035	COG1334	flagellar protein FlaG
GPY41_RS17040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY41_RS17045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY41_RS17050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY41_RS17055	COG2837	iron assimilation
GPY41_RS17080	COG1393	Belongs to the ArsC family
GPY41_RS17100	COG3385	transposase activity
GPY41_RS17110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY41_RS17115	COG2716	regulation of RNA biosynthetic process
GPY41_RS17120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY41_RS17135	COG4783	chaperone-mediated protein folding
GPY41_RS17140	COG1393	Belongs to the ArsC family
GPY41_RS17160	COG2233	PERMEase
GPY41_RS17165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY41_RS17175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY41_RS17190	COG1960	acyl-CoA dehydrogenase activity
GPY41_RS17245	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY41_RS17255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY41_RS17265	COG2226	methyltransferase
GPY41_RS17270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY41_RS17275	COG1388	LysM domain
GPY41_RS17275	COG0741	lytic transglycosylase activity
GPY41_RS17290	COG0347	Belongs to the P(II) protein family
GPY41_RS17310	COG0587	DNA-directed DNA polymerase activity
GPY41_RS17335	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY41_RS17340	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY41_RS17345	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY41_RS17350	COG0750	zinc metalloprotease
GPY41_RS17360	COG0575	Belongs to the CDS family
GPY41_RS17370	COG0233	cytoplasmic translational termination
GPY41_RS17390	COG0024	Methionine aminopeptidase
GPY41_RS17395	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY41_RS17410	COG3098	single-species biofilm formation
GPY41_RS17440	COG1671	Belongs to the UPF0178 family
GPY41_RS17445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY41_RS17455	COG0254	rRNA binding
GPY41_RS17460	COG1720	tRNA m6t6A37 methyltransferase activity
GPY41_RS17485	COG0733	neurotransmitter:sodium symporter activity
GPY41_RS17500	COG0514	ATP-dependent DNA helicase (RecQ)
GPY41_RS17510	COG0745	RESPONSE REGULATOR receiver
GPY41_RS17510	COG3706	GGDEF domain
GPY41_RS17520	COG1477	protein flavinylation
GPY41_RS17555	COG0271	Belongs to the BolA IbaG family
GPY41_RS17575	COG2211	Major facilitator Superfamily
GPY41_RS17585	COG1595	DNA-templated transcription, initiation
GPY41_RS17595	COG3248	Nucleoside-binding outer membrane protein
GPY41_RS17600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY41_RS17605	COG0693	protein deglycase activity
GPY41_RS17610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY41_RS17615	COG2166	iron-sulfur cluster assembly
GPY41_RS17620	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY41_RS17625	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY41_RS17645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY41_RS17650	COG1074	ATP-dependent DNA helicase activity
GPY41_RS17655	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY41_RS17660	COG3083	sulfuric ester hydrolase activity
GPY41_RS17675	COG3141	response to X-ray
GPY41_RS17680	COG2171	N-acyltransferase activity
GPY41_RS17685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY41_RS17695	COG1349	DNA-binding transcription factor activity
GPY41_RS17700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY41_RS17715	COG0569	domain protein
GPY41_RS17715	COG0189	ligase activity
GPY41_RS17735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY41_RS17745	COG0840	transmembrane signaling receptor activity
GPY41_RS17750	COG2017	converts alpha-aldose to the beta-anomer
GPY41_RS17760	COG1085	galactose-1-phosphate uridylyltransferase
GPY41_RS17765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY41_RS17770	COG1609	Transcriptional regulator
GPY41_RS17780	COG3250	beta-galactosidase activity
GPY41_RS17785	COG2731	YhcH YjgK YiaL family protein
GPY41_RS17790	COG0531	amino acid
GPY41_RS17795	COG0531	amino acid
GPY41_RS17810	COG0583	DNA-binding transcription factor activity
GPY41_RS17815	COG2059	Chromate
GPY41_RS17865	COG4964	Belongs to the GSP D family
GPY41_RS17900	COG1022	Amp-dependent synthetase and ligase
GPY41_RS17905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY41_RS17925	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY41_RS17935	COG0560	Phosphoserine phosphatase
GPY41_RS17960	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY41_RS17965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY41_RS17970	COG0084	hydrolase, TatD family'
GPY41_RS17985	COG3706	GGDEF domain
GPY41_RS17995	COG0456	acetyltransferase
GPY41_RS18005	COG3153	acetyltransferase
GPY41_RS18030	COG0534	Mate efflux family protein
GPY41_RS18040	COG4785	May be involved in cell division
GPY41_RS18090	COG0195	Participates in both transcription termination and antitermination
GPY41_RS18110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY41_RS18120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY41_RS18125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY41_RS18135	COG1534	Rna-binding protein
GPY41_RS18145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY41_RS18150	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY41_RS18155	COG2832	Protein of unknown function (DUF454)
GPY41_RS18165	COG0739	heme binding
GPY41_RS18180	COG0316	Belongs to the HesB IscA family
GPY41_RS18190	COG0628	permease
GPY41_RS18200	COG2205	protein histidine kinase activity
GPY41_RS18200	COG0784	Response regulator, receiver
GPY41_RS18210	COG0601	transmembrane transport
GPY41_RS18215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY41_RS18220	COG0444	Belongs to the ABC transporter superfamily
GPY41_RS18225	COG4608	Belongs to the ABC transporter superfamily
GPY41_RS18235	COG2971	BadF BadG BcrA BcrD
GPY41_RS18250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY41_RS18255	COG3842	ATPase activity
GPY41_RS18265	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY41_RS18270	COG0004	ammonium transporteR
GPY41_RS18275	COG0347	Belongs to the P(II) protein family
GPY41_RS18285	COG3835	regulator
GPY41_RS18290	COG2610	gluconate transmembrane transporter activity
GPY41_RS18295	COG1929	Belongs to the glycerate kinase type-1 family
GPY41_RS18300	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY41_RS18305	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY41_RS18310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY41_RS18315	COG1643	Atp-dependent helicase
GPY41_RS18320	COG1489	DNA binding
GPY41_RS18325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY41_RS18340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY41_RS18355	COG0842	Transport permease protein
GPY41_RS18360	COG1131	(ABC) transporter
GPY41_RS18365	COG0659	secondary active sulfate transmembrane transporter activity
GPY41_RS18370	COG0288	reversible hydration of carbon dioxide
GPY41_RS18385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY41_RS18390	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY41_RS18395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY41_RS18400	COG2186	Transcriptional regulator
GPY41_RS18405	COG3023	N-Acetylmuramoyl-L-alanine amidase
GPY41_RS18420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY41_RS18425	COG1459	type II secretion system
GPY41_RS18445	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY41_RS18470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY41_RS18475	COG4137	Cytochrome C assembly protein
GPY41_RS18480	COG4536	flavin adenine dinucleotide binding
GPY41_RS18500	COG0612	Peptidase, M16
GPY41_RS18515	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY41_RS18520	COG0511	ligase activity, forming carbon-carbon bonds
GPY41_RS18520	COG5016	pyruvate
GPY41_RS18575	COG0527	aspartate kinase activity
GPY41_RS18580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY41_RS18600	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY41_RS18605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY41_RS18610	COG1388	LysM domain
GPY41_RS18610	COG4942	peptidase
GPY41_RS18630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY41_RS18660	COG3956	TIGRFAM MazG family protein
GPY41_RS18665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY41_RS18670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY41_RS18675	COG2205	protein histidine kinase activity
GPY41_RS18675	COG3437	response regulator, receiver
GPY41_RS18675	COG4999	Histidine kinase
GPY41_RS18675	COG3850	Histidine kinase
GPY41_RS18695	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY41_RS18705	COG1381	Involved in DNA repair and RecF pathway recombination
GPY41_RS18720	COG0681	Belongs to the peptidase S26 family
GPY41_RS18730	COG3086	response to oxidative stress
GPY41_RS18745	COG1595	DNA-templated transcription, initiation
GPY41_RS18750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY41_RS18760	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY41_RS18765	COG0354	folic acid binding
GPY41_RS18780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY41_RS18785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY41_RS18790	COG3079	Belongs to the UPF0149 family
GPY41_RS18795	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY41_RS18805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY41_RS18815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY41_RS18830	COG1279	arginine transmembrane transporter activity
GPY41_RS18835	COG0668	transmembrane transport
GPY41_RS18845	COG0191	fructose-bisphosphate aldolase activity
GPY41_RS18855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY41_RS18865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY41_RS18885	COG2356	endonuclease I
GPY41_RS18895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY41_RS18925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY41_RS18930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY41_RS18935	COG0762	integral membrane protein
GPY41_RS18955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY41_RS18985	COG0741	lytic transglycosylase activity
GPY41_RS19005	COG0840	transmembrane signaling receptor activity
GPY41_RS19105	COG1609	Transcriptional regulator
GPY41_RS19110	COG3394	polysaccharide catabolic process
GPY41_RS19120	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY41_RS19130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY41_RS19135	COG0726	polysaccharide deacetylase
GPY41_RS19150	COG0795	lipopolysaccharide-transporting ATPase activity
GPY41_RS19155	COG0795	lipopolysaccharide-transporting ATPase activity
GPY41_RS19165	COG2927	DNA polymerase III (CHI subunit)
GPY41_RS19180	COG4269	membrane
GPY41_RS19190	COG0456	acetyltransferase
GPY41_RS19225	COG0251	oxidation-reduction process
GPY41_RS19230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY41_RS19245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY41_RS19255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY41_RS19260	COG3164	Protein of unknown function
GPY41_RS19265	COG1530	ribonuclease E activity
GPY41_RS19275	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY41_RS19280	COG1792	Involved in formation and maintenance of cell shape
GPY41_RS19285	COG1077	Cell shape determining protein MreB Mrl
GPY41_RS19330	COG1459	type II secretion system
GPY41_RS19335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY41_RS19345	COG3409	Peptidoglycan-binding domain 1 protein
GPY41_RS19345	COG3267	Type II secretory pathway component ExeA
GPY41_RS19370	COG2200	EAL domain
GPY41_RS19370	COG2199	diguanylate cyclase activity
GPY41_RS19400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY41_RS19405	COG0527	aspartate kinase activity
GPY41_RS19410	COG1410	methionine synthase
GPY41_RS19410	COG0646	methionine synthase
GPY41_RS19420	COG3706	GGDEF domain
GPY41_RS19420	COG0745	RESPONSE REGULATOR receiver
GPY41_RS19495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY41_RS19525	COG0735	belongs to the Fur family
GPY41_RS19540	COG0432	Pfam Uncharacterised protein family UPF0047
GPY41_RS19550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY41_RS19555	COG0305	Participates in initiation and elongation during chromosome replication
GPY41_RS19585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY41_RS19590	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY41_RS19635	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY41_RS19665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY41_RS19670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY41_RS19685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY41_RS19690	COG0527	aspartate kinase activity
GPY41_RS19690	COG0460	homoserine dehydrogenase
GPY41_RS19695	COG0626	cystathionine gamma-synthase activity
GPY41_RS19705	COG0281	malic enzyme
GPY41_RS19715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY41_RS19720	COG1609	Transcriptional regulator
GPY41_RS19740	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY41_RS19755	COG1494	fructose-1,6-bisphosphatase
GPY41_RS19785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY41_RS19795	COG2906	2 iron, 2 sulfur cluster binding
GPY41_RS19805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY41_RS19830	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY41_RS19835	COG2964	Protein conserved in bacteria
GPY41_RS19840	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY41_RS19860	COG1047	Peptidyl-prolyl cis-trans
GPY41_RS19875	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY41_RS19880	COG0488	(ABC) transporter
GPY41_RS19890	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY41_RS19900	COG3954	Phosphoribulokinase
GPY41_RS19905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY41_RS19915	COG1012	belongs to the aldehyde dehydrogenase family
GPY41_RS19925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY41_RS19945	COG0180	Tryptophanyl-tRNA synthetase
GPY41_RS19950	COG0546	phosphoglycolate phosphatase activity
GPY41_RS19960	COG0557	exoribonuclease II activity
GPY41_RS19965	COG0402	S-adenosylhomocysteine deaminase activity
GPY41_RS19980	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY41_RS19985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY41_RS19990	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY41_RS19995	COG0330	HflC and HflK could
GPY41_RS20000	COG0330	HflC and HflK could
GPY41_RS20005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY41_RS20025	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPY41_RS20030	COG0802	atpase or kinase
GPY41_RS20035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY41_RS20110	COG0471	metal ion transport
GPY41_RS20120	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY41_RS20130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY41_RS20145	COG1045	serine acetyltransferase
GPY41_RS20150	COG4942	peptidase
GPY41_RS20175	COG1053	succinate dehydrogenase
GPY41_RS20180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY41_RS20190	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY41_RS20205	COG1509	lysine 2,3-aminomutase activity
GPY41_RS20210	COG1285	pathogenesis
GPY41_RS20230	COG0534	Mate efflux family protein
GPY41_RS20245	COG3678	ATP-independent chaperone mediated protein folding
GPY41_RS20250	COG0745	RESPONSE REGULATOR receiver
GPY41_RS20255	COG2205	protein histidine kinase activity
GPY41_RS20265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY41_RS20275	COG1027	Aspartate ammonia-lyase
GPY41_RS20280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY41_RS20285	COG4232	protein-disulfide reductase activity
GPY41_RS20295	COG2095	MarC family integral membrane protein
GPY41_RS20305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY41_RS20320	COG2205	protein histidine kinase activity
GPY41_RS20320	COG2198	Histidine kinase
GPY41_RS20320	COG0784	Response regulator, receiver
GPY41_RS20325	COG2814	Major facilitator Superfamily
GPY41_RS20340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY41_RS20350	COG0511	ligase activity, forming carbon-carbon bonds
GPY41_RS20355	COG0439	Biotin carboxylase
GPY41_RS20370	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY41_RS20400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY41_RS20405	COG1518	maintenance of DNA repeat elements
GPY41_RS20415	COG1857	crispr-associated protein
GPY41_RS20450	COG0840	transmembrane signaling receptor activity
GPY41_RS20455	COG0789	Transcriptional regulator
GPY41_RS20485	COG1253	flavin adenine dinucleotide binding
GPY41_RS20490	COG3068	Protein conserved in bacteria
GPY41_RS20495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY41_RS20500	COG1573	uracil-dna glycosylase
GPY41_RS20525	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY41_RS20565	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY41_RS20605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY41_RS20615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY41_RS20710	COG4206	TonB-dependent receptor
GPY41_RS20755	COG3339	Conserved Protein
GPY41_RS20795	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY41_RS20845	COG2937	Belongs to the GPAT DAPAT family
GPY41_RS20855	COG3161	chorismate lyase activity
GPY41_RS20860	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY41_RS20880	COG2177	Part of the ABC transporter FtsEX involved in
GPY41_RS20885	COG2884	Cell division ATP-binding protein ftsE
GPY41_RS20890	COG0552	protein localization to endoplasmic reticulum
GPY41_RS20895	COG0742	ribosomal rna small subunit methyltransferase
GPY41_RS20905	COG2095	MarC family integral membrane protein
GPY41_RS20945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY41_RS20950	COG0640	Transcriptional regulator
GPY41_RS20955	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY41_RS20960	COG1280	lysine exporter protein (LysE YggA)
GPY41_RS20965	COG2267	carboxylic ester hydrolase activity
GPY41_RS20970	COG0561	phosphatase activity
GPY41_RS20990	COG2199	diguanylate cyclase activity
GPY41_RS20990	COG2200	EAL domain
GPY41_RS20990	COG3287	FIST C domain
GPY41_RS20995	COG1011	Hydrolase
GPY41_RS21015	COG0019	diaminopimelate decarboxylase activity
GPY41_RS21030	COG3072	Adenylate cyclase
GPY41_RS21045	COG2959	enzyme of heme biosynthesis
GPY41_RS21055	COG2081	HI0933 family
GPY41_RS21065	COG1528	Iron-storage protein
GPY41_RS21070	COG0589	response to stress
GPY41_RS21090	COG5001	Diguanylate cyclase
GPY41_RS21090	COG5002	protein histidine kinase activity
GPY41_RS21095	COG1522	sequence-specific DNA binding
GPY41_RS21105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY41_RS21110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY41_RS21150	COG3550	peptidyl-serine autophosphorylation
GPY41_RS21200	COG0800	Aldolase
GPY41_RS21210	COG3265	gluconokinase activity
GPY41_RS21215	COG0129	dihydroxy-acid dehydratase activity
GPY41_RS21220	COG1609	Transcriptional regulator
GPY41_RS21235	COG0515	serine threonine protein kinase
GPY41_RS21235	COG2815	serine threonine protein kinase
GPY41_RS21270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY41_RS21280	COG4166	transmembrane transport
GPY41_RS21285	COG4172	Belongs to the ABC transporter superfamily
GPY41_RS21325	COG1309	transcriptional regulator
GPY41_RS21330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY41_RS21335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY41_RS21340	COG2960	long-chain fatty acid transporting porin activity
GPY41_RS21350	COG0583	DNA-binding transcription factor activity
GPY41_RS21385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY41_RS21395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY41_RS21420	COG0551	DNA topoisomerase type I activity
GPY41_RS21430	COG0758	DNA mediated transformation
GPY41_RS21440	COG0242	peptide deformylase activity
GPY41_RS21445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY41_RS21450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY41_RS21450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY41_RS21455	COG0569	domain protein
GPY41_RS21460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY41_RS21465	COG1272	protein, Hemolysin III
GPY41_RS21470	COG4326	sporulation control protein
GPY41_RS21475	COG3084	Protein conserved in bacteria
GPY41_RS21485	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY41_RS21490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY41_RS21495	COG0204	Acyl-transferase
GPY41_RS21505	COG0606	chelatase, subunit chli
GPY41_RS21515	COG3978	acetolactate synthase activity
GPY41_RS21520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY41_RS21525	COG0129	dihydroxy-acid dehydratase activity
GPY41_RS21535	COG0583	DNA-binding transcription factor activity
GPY41_RS21540	COG2814	Major facilitator Superfamily
GPY41_RS21550	COG0765	amino acid transport
GPY41_RS21600	COG3312	ion transport
GPY41_RS21605	COG1475	DNA binding
GPY41_RS21610	COG1192	Involved in chromosome partitioning
GPY41_RS21620	COG0445	tRNA wobble uridine modification
GPY41_RS21625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY41_RS21630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY41_RS21635	COG0706	membrane insertase activity
GPY41_RS21640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY41_RS21655	COG1126	abc transporter atp-binding protein
GPY41_RS21675	COG0592	DNA-directed DNA polymerase activity
GPY41_RS21685	COG0187	DNA topoisomerase II activity
GPY41_RS21690	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY41_RS21700	COG3977	Valine--pyruvate aminotransferase
GPY41_RS21710	COG0751	glycine-tRNA ligase activity
GPY41_RS21720	COG2119	membrane
GPY41_RS21745	COG0604	alcohol dehydrogenase
GPY41_RS21750	COG0183	Belongs to the thiolase family
GPY41_RS21760	COG1739	Uncharacterized protein family UPF0029
GPY41_RS21765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY41_RS21770	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPY41_RS21805	COG2132	Multicopper oxidase
GPY41_RS21825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY41_RS21845	COG0006	proline dipeptidase activity
GPY41_RS21845	COG0006	proline dipeptidase activity
GPY41_RS21885	COG0210	DNA helicase
GPY41_RS21895	COG1280	lysine exporter protein (LysE YggA)
GPY41_RS21905	COG2962	Rard protein
GPY41_RS21910	COG0514	ATP-dependent DNA helicase (RecQ)
GPY41_RS21920	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY41_RS21935	COG3118	belongs to the thioredoxin family
GPY41_RS21940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY41_RS22045	COG1322	Protein conserved in bacteria
GPY41_RS22055	COG3165	ubiquinone biosynthetic process from chorismate
GPY41_RS22065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY41_RS22075	COG0805	protein transport
GPY41_RS22080	COG0084	hydrolase, TatD family'
GPY41_RS22090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY41_RS22090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY41_RS22095	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY41_RS22120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY41_RS22125	COG5001	Diguanylate cyclase
GPY41_RS22125	COG3300	MHYT domain
GPY41_RS22130	COG2204	response regulator
GPY41_RS22135	COG3852	Histidine kinase
GPY41_RS22145	COG0174	glutamine synthetase
GPY41_RS22165	COG1295	ribonuclease BN
GPY41_RS22175	COG0456	acetyltransferase
GPY41_RS22195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY41_RS22200	COG3031	protein transport across the cell outer membrane
GPY41_RS22210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY41_RS22215	COG1459	type II secretion system
GPY41_RS22220	COG2165	general secretion pathway protein
GPY41_RS22225	COG2165	general secretion pathway protein
GPY41_RS22230	COG2165	general secretion pathway protein
GPY41_RS22235	COG4795	General secretion pathway protein
GPY41_RS22240	COG3156	type II secretion system protein K
GPY41_RS22245	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY41_RS22250	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY41_RS22260	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY41_RS22265	COG0494	nUDIX hydrolase
GPY41_RS22280	COG0596	Alpha beta hydrolase
GPY41_RS22295	COG2183	response to ionizing radiation
GPY41_RS22305	COG0745	RESPONSE REGULATOR receiver
GPY41_RS22310	COG2205	protein histidine kinase activity
GPY41_RS22315	COG2233	PERMEase
GPY41_RS22320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY41_RS22325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY41_RS22330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY41_RS22355	COG0848	biopolymer transport protein
GPY41_RS22360	COG0811	peptide transport
GPY41_RS22365	COG0811	peptide transport
GPY41_RS22375	COG4206	TonB-dependent receptor
GPY41_RS22380	COG4174	ABC transporter (Permease)
GPY41_RS22385	COG4239	(ABC) transporter, permease
GPY41_RS22390	COG0747	negative chemotaxis
GPY41_RS22395	COG0444	Belongs to the ABC transporter superfamily
GPY41_RS22400	COG4608	Belongs to the ABC transporter superfamily
GPY41_RS22420	COG1561	YicC-like family, N-terminal region
GPY41_RS22435	COG1560	Kdo2-lipid A biosynthetic process
GPY41_RS22455	COG2003	Belongs to the UPF0758 family
GPY41_RS22490	COG0859	PFAM glycosyl transferase family 9
GPY41_RS22495	COG0463	Glycosyl transferase, family 2
GPY41_RS22500	COG0859	PFAM glycosyl transferase family 9
GPY41_RS22505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY41_RS22510	COG3642	lipopolysaccharide core region biosynthetic process
GPY41_RS22515	COG3083	sulfuric ester hydrolase activity
GPY41_RS22525	COG1086	Polysaccharide biosynthesis protein
GPY41_RS22530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY41_RS22535	COG1083	cytidylyl-transferase
GPY41_RS22550	COG2089	acid synthase
GPY41_RS22580	COG0110	maltose O-acetyltransferase activity
GPY41_RS22585	COG1519	Transferase
GPY41_RS22605	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY41_RS22625	COG1596	polysaccharide export
GPY41_RS22645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY41_RS22660	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPY41_RS22710	COG0367	asparagine synthase
GPY41_RS22715	COG0438	transferase activity, transferring glycosyl groups
GPY41_RS22720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY41_RS22730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY41_RS22755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY41_RS22760	COG3064	Membrane
GPY41_RS22770	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY41_RS22870	COG0201	protein transport
GPY41_RS22885	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY41_RS22910	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY41_RS22915	COG3266	domain, Protein
GPY41_RS22915	COG3061	Opacity-associated protein A
GPY41_RS22925	COG2153	protein acetylation
GPY41_RS22935	COG0737	Belongs to the 5'-nucleotidase family
GPY41_RS22940	COG1648	precorrin-2 dehydrogenase activity
GPY41_RS22940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY41_RS22950	COG2895	sulfate adenylyltransferase (ATP) activity
GPY41_RS22955	COG0471	metal ion transport
GPY41_RS22955	COG3273	potassium ion transport
GPY41_RS22980	COG0577	efflux transmembrane transporter activity
GPY41_RS22980	COG1136	(ABC) transporter
GPY41_RS22995	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY41_RS23010	COG0729	surface antigen
GPY41_RS23015	COG2911	Protein conserved in bacteria
GPY41_RS23020	COG2105	PFAM AIG2 family protein
GPY41_RS23040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY41_RS23045	COG0163	prenyltransferase activity
GPY41_RS23050	COG4143	(ABC) transporter
GPY41_RS23055	COG1178	ABC-type Fe3 transport system permease component
GPY41_RS23065	COG3028	Belongs to the UPF0307 family
GPY41_RS23070	COG0312	modulator of DNA gyrase
GPY41_RS23075	COG2239	Acts as a magnesium transporter
GPY41_RS23080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS23085	COG1660	Displays ATPase and GTPase activities
GPY41_RS23090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS23095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY41_RS23105	COG1137	ATPase activity
GPY41_RS23110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY41_RS23120	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GPY41_RS23125	COG0517	IMP dehydrogenase activity
GPY41_RS23125	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY41_RS23135	COG1127	ABC transporter
GPY41_RS23140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY41_RS23145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY41_RS23150	COG2854	intermembrane phospholipid transfer
GPY41_RS23160	COG5007	Belongs to the BolA IbaG family
GPY41_RS23165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY41_RS23170	COG0204	Acyl-transferase
GPY41_RS23175	COG0589	response to stress
GPY41_RS23195	COG0039	L-malate dehydrogenase activity
GPY41_RS23200	COG0142	geranyltranstransferase activity
GPY41_RS23205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY41_RS23220	COG2966	Psort location CytoplasmicMembrane, score
GPY41_RS23225	COG3610	response to peptide
GPY41_RS23275	COG0066	3-isopropylmalate dehydratase activity
GPY41_RS23285	COG0473	3-isopropylmalate dehydrogenase activity
GPY41_RS23315	COG1022	Amp-dependent synthetase and ligase
GPY41_RS23320	COG0028	Belongs to the TPP enzyme family
GPY41_RS23325	COG0440	acetolactate synthase activity
GPY41_RS23330	COG3706	GGDEF domain
GPY41_RS23340	COG0469	pyruvate kinase activity
GPY41_RS23345	COG1349	DNA-binding transcription factor activity
GPY41_RS23350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY41_RS23355	COG3722	fumarate hydratase activity
GPY41_RS23365	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS23365	COG2213	PTS system mannitol-specific
GPY41_RS23370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY41_RS23385	COG3550	peptidyl-serine autophosphorylation
GPY41_RS23420	COG0328	RNA-DNA hybrid ribonuclease activity
GPY41_RS23460	COG2003	Belongs to the UPF0758 family
GPY41_RS23465	COG1349	DNA-binding transcription factor activity
GPY41_RS23475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY41_RS23480	COG0738	Major facilitator superfamily
GPY41_RS23490	COG3039	Transposase
GPY41_RS23515	COG1349	DNA-binding transcription factor activity
GPY41_RS23520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY41_RS23525	COG3715	PTS system
GPY41_RS23530	COG3716	PTS system mannose fructose sorbose family IID component
GPY41_RS23535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY41_RS23535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY41_RS23540	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GPY41_RS23575	COG1414	Transcriptional regulator
GPY41_RS23585	COG1028	Short-chain dehydrogenase reductase Sdr
GPY41_RS23595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY41_RS23600	COG0800	Aldolase
GPY41_RS23620	COG0582	viral genome integration into host DNA
GPY41_RS23630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY41_RS23640	COG1610	YqeY-like protein
GPY41_RS23645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY41_RS23655	COG0596	Alpha beta hydrolase
GPY41_RS23665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY41_RS23670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY41_RS23680	COG0617	tRNA 3'-terminal CCA addition
GPY41_RS23685	COG3409	Peptidoglycan-binding domain 1 protein
GPY41_RS23685	COG3267	Type II secretory pathway component ExeA
GPY41_RS23690	COG4991	sh3 domain protein
GPY41_RS23695	COG0306	phosphate transporter
GPY41_RS23700	COG1392	Phosphate transport regulator
GPY41_RS23705	COG3025	triphosphatase activity
GPY41_RS23710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY41_RS23730	COG1538	Outer membrane efflux protein
GPY41_RS23735	COG0494	nUDIX hydrolase
GPY41_RS23740	COG3151	Protein conserved in bacteria
GPY41_RS23750	COG3150	esterase
GPY41_RS23755	COG0187	DNA topoisomerase II activity
GPY41_RS23765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY41_RS23770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY41_RS23775	COG3105	Protein conserved in bacteria
GPY41_RS23780	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY41_RS23800	COG0723	plastoquinol--plastocyanin reductase activity
GPY41_RS23805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY41_RS23810	COG2857	Cytochrome c1
GPY41_RS23815	COG0625	glutathione transferase activity
GPY41_RS23820	COG2969	positive regulation of protein catabolic process
GPY41_RS23825	COG2823	Periplasmic or secreted lipoprotein
GPY41_RS23830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY41_RS23840	COG3107	peptidoglycan biosynthetic process
GPY41_RS23845	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY41_RS23860	COG3116	cell division
GPY41_RS23865	COG0768	penicillin binding
GPY41_RS23875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY41_RS23880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY41_RS23890	COG0772	Belongs to the SEDS family
GPY41_RS23900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY41_RS23905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY41_RS23910	COG0849	cell division
GPY41_RS23915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY41_RS23930	COG0653	protein targeting
GPY41_RS23935	COG0494	nUDIX hydrolase
GPY41_RS23945	COG0505	Belongs to the CarA family
GPY41_RS23960	COG0730	response to heat
GPY41_RS23965	COG0583	DNA-binding transcription factor activity
GPY41_RS23970	COG2860	membrane
GPY41_RS23975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY41_RS23985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY41_RS23995	COG0493	'glutamate synthase
GPY41_RS24000	COG0070	glutamate synthase
GPY41_RS24000	COG0067	glutamate synthase
GPY41_RS24000	COG0069	glutamate synthase activity
GPY41_RS24010	COG0070	glutamate synthase
GPY41_RS24010	COG0069	glutamate synthase activity
GPY41_RS24010	COG0067	glutamate synthase
GPY41_RS24015	COG1242	4 iron, 4 sulfur cluster binding
GPY41_RS24025	COG0784	Response regulator, receiver
GPY41_RS24025	COG5002	protein histidine kinase activity
GPY41_RS24025	COG2198	Histidine kinase
GPY41_RS24035	COG0745	RESPONSE REGULATOR receiver
GPY41_RS24070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY41_RS24100	COG1115	amino acid carrier protein
GPY41_RS24105	COG3022	response to hydroperoxide
GPY41_RS24110	COG0513	Belongs to the DEAD box helicase family
GPY41_RS24115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY41_RS24125	COG0716	FMN binding
GPY41_RS24135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY41_RS24140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY41_RS24150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY41_RS24165	COG0667	Aldo Keto reductase
GPY41_RS24190	COG0730	response to heat
GPY41_RS24210	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY41_RS24215	COG0583	DNA-binding transcription factor activity
GPY41_RS24220	COG0640	Transcriptional regulator
GPY41_RS24230	COG0728	peptidoglycan biosynthetic process
GPY41_RS24235	COG0196	riboflavin kinase activity
GPY41_RS24240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY41_RS24250	COG1047	Peptidyl-prolyl cis-trans
GPY41_RS24265	COG3275	phosphorelay sensor kinase activity
GPY41_RS24270	COG1966	Carbon starvation protein
GPY41_RS24290	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY41_RS24295	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY41_RS24300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY41_RS24305	COG0287	Prephenate dehydrogenase
GPY41_RS24305	COG1605	Chorismate mutase
GPY41_RS24310	COG0739	heme binding