locus-tag	class	description
H6S61_RS00060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H6S61_RS00070	COG1254	Belongs to the acylphosphatase family
H6S61_RS00075	COG2920	part of a sulfur-relay system
H6S61_RS00080	COG0670	Belongs to the BI1 family
H6S61_RS00085	COG1126	abc transporter atp-binding protein
H6S61_RS00090	COG0765	amino acid transport
H6S61_RS00095	COG4597	amino acid ABC transporter
H6S61_RS00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6S61_RS00110	COG0437	4 iron, 4 sulfur cluster binding
H6S61_RS00115	COG0348	domain, Protein
H6S61_RS00120	COG0204	Acyl-transferase
H6S61_RS00180	COG1846	Transcriptional regulator
H6S61_RS00200	COG3971	2-oxopent-4-enoate hydratase activity
H6S61_RS00235	COG3384	dioxygenase
H6S61_RS00240	COG1012	belongs to the aldehyde dehydrogenase family
H6S61_RS00250	COG1960	acyl-CoA dehydrogenase activity
H6S61_RS00255	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H6S61_RS00270	COG1115	amino acid carrier protein
H6S61_RS00300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H6S61_RS00315	COG3290	protein histidine kinase activity
H6S61_RS00320	COG4565	transcriptional regulatory protein
H6S61_RS00325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H6S61_RS00330	COG0363	glucosamine-6-phosphate deaminase activity
H6S61_RS00335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H6S61_RS00375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H6S61_RS00385	COG0438	transferase activity, transferring glycosyl groups
H6S61_RS00420	COG0438	transferase activity, transferring glycosyl groups
H6S61_RS00430	COG2204	response regulator
H6S61_RS00460	COG1366	Belongs to the anti-sigma-factor antagonist family
H6S61_RS00465	COG1793	dna ligase
H6S61_RS00470	COG3706	GGDEF domain
H6S61_RS00480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H6S61_RS00495	COG2996	Protein conserved in bacteria
H6S61_RS00500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H6S61_RS00500	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H6S61_RS00505	COG3008	intermembrane lipid transfer
H6S61_RS00510	COG2995	paraquat-inducible protein a
H6S61_RS00515	COG1132	(ABC) transporter
H6S61_RS00520	COG1956	GAF domain-containing protein
H6S61_RS00525	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H6S61_RS00540	COG0308	aminopeptidase N
H6S61_RS00550	COG2902	Dehydrogenase
H6S61_RS00565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H6S61_RS00565	COG0116	Belongs to the methyltransferase superfamily
H6S61_RS00575	COG0488	(ABC) transporter
H6S61_RS00590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H6S61_RS00595	COG1067	ATP-dependent peptidase activity
H6S61_RS00600	COG3120	sequence-specific DNA binding
H6S61_RS00620	COG4128	Pfam Zonular occludens toxin
H6S61_RS00665	COG0784	Response regulator, receiver
H6S61_RS00665	COG2205	protein histidine kinase activity
H6S61_RS00680	COG3278	Belongs to the heme-copper respiratory oxidase family
H6S61_RS00695	COG2010	Cytochrome c
H6S61_RS00705	COG2217	Heavy metal translocating P-type atpase
H6S61_RS00720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6S61_RS00725	COG0589	response to stress
H6S61_RS00740	COG2992	FlgJ-related protein
H6S61_RS00750	COG3842	ATPase activity
H6S61_RS00755	COG1176	ABC-type spermidine putrescine transport system, permease component I
H6S61_RS00760	COG1177	transmembrane transport
H6S61_RS00770	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H6S61_RS00775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H6S61_RS00780	COG0004	ammonium transporteR
H6S61_RS00810	COG0437	4 iron, 4 sulfur cluster binding
H6S61_RS00815	COG3383	formate dehydrogenase (NAD+) activity
H6S61_RS00815	COG0243	molybdopterin cofactor binding
H6S61_RS00845	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H6S61_RS00855	COG0488	(ABC) transporter
H6S61_RS00870	COG3852	Histidine kinase
H6S61_RS00875	COG2204	response regulator
H6S61_RS00885	COG4662	Binding-protein-dependent transport system inner membrane component
H6S61_RS00890	COG3842	ATPase activity
H6S61_RS00895	COG0746	molybdenum cofactor guanylyltransferase activity
H6S61_RS00910	COG1940	carbohydrate kinase activity
H6S61_RS00915	COG3148	PFAM DTW domain containing protein
H6S61_RS00925	COG0840	transmembrane signaling receptor activity
H6S61_RS00930	COG0791	NLP P60 protein
H6S61_RS00940	COG3706	GGDEF domain
H6S61_RS00960	COG0307	riboflavin synthase, alpha
H6S61_RS00965	COG0534	Mate efflux family protein
H6S61_RS01010	COG4115	mRNA cleavage
H6S61_RS01015	COG2161	toxin-antitoxin pair type II binding
H6S61_RS01060	COG1942	4-Oxalocrotonate Tautomerase
H6S61_RS01295	COG0454	-acetyltransferase
H6S61_RS01330	COG3093	addiction module antidote protein HigA
H6S61_RS01335	COG3549	Plasmid maintenance system killer
H6S61_RS01515	COG2944	sequence-specific DNA binding
H6S61_RS01520	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
H6S61_RS01810	COG1335	isochorismatase
H6S61_RS01870	COG4628	conserved protein (DUF2132)
H6S61_RS01965	COG0454	-acetyltransferase
H6S61_RS02050	COG4628	conserved protein (DUF2132)
H6S61_RS02245	COG0346	lactoylglutathione lyase activity
H6S61_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS02260	COG4628	conserved protein (DUF2132)
H6S61_RS02310	COG1942	4-Oxalocrotonate Tautomerase
H6S61_RS02360	COG1683	Conserved Protein
H6S61_RS02560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H6S61_RS02580	COG4326	sporulation control protein
H6S61_RS02590	COG1228	amidohydrolase
H6S61_RS02600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H6S61_RS02605	COG2986	histidine ammonia-lyase
H6S61_RS02615	COG5640	endopeptidase activity
H6S61_RS02620	COG2020	methyltransferase activity
H6S61_RS02625	COG0277	FAD linked oxidase domain protein
H6S61_RS02625	COG0247	lactate metabolic process
H6S61_RS02640	COG2885	chlorophyll binding
H6S61_RS02655	COG0295	cytidine deaminase activity
H6S61_RS02660	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H6S61_RS02665	COG0500	methyltransferase
H6S61_RS02675	COG0776	regulation of translation
H6S61_RS02695	COG0072	phenylalanine-tRNA ligase activity
H6S61_RS02695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6S61_RS02700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H6S61_RS02785	COG1166	arginine decarboxylase activity
H6S61_RS02790	COG0010	Belongs to the arginase family
H6S61_RS02795	COG2814	Major facilitator Superfamily
H6S61_RS02800	COG5380	lipid catabolic process
H6S61_RS02805	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H6S61_RS02830	COG1643	Atp-dependent helicase
H6S61_RS02840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H6S61_RS02880	COG2894	cell division
H6S61_RS02890	COG4964	Belongs to the GSP D family
H6S61_RS02920	COG3713	MltA-interacting MipA family protein
H6S61_RS02940	COG3706	GGDEF domain
H6S61_RS02950	COG0443	Heat shock 70 kDa protein
H6S61_RS02955	COG0443	Heat shock 70 kDa protein
H6S61_RS02985	COG2165	general secretion pathway protein
H6S61_RS03000	COG0297	glycogen (starch) synthase activity
H6S61_RS03000	COG0438	transferase activity, transferring glycosyl groups
H6S61_RS03030	COG1596	polysaccharide export
H6S61_RS03045	COG1115	amino acid carrier protein
H6S61_RS03050	COG1132	(ABC) transporter
H6S61_RS03055	COG1132	(ABC) transporter
H6S61_RS03070	COG0783	Belongs to the Dps family
H6S61_RS03085	COG0814	amino acid
H6S61_RS03090	COG1597	lipid kinase activity
H6S61_RS03100	COG4667	esterase of the alpha-beta hydrolase superfamily
H6S61_RS03105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H6S61_RS03120	COG0583	DNA-binding transcription factor activity
H6S61_RS03125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H6S61_RS03130	COG1328	CTP reductase activity
H6S61_RS03135	COG5001	Diguanylate cyclase
H6S61_RS03135	COG3300	MHYT domain
H6S61_RS03150	COG2200	EAL domain
H6S61_RS03150	COG2199	diguanylate cyclase activity
H6S61_RS03155	COG3706	GGDEF domain
H6S61_RS03165	COG4191	Histidine kinase
H6S61_RS03165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6S61_RS03170	COG0471	metal ion transport
H6S61_RS03185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H6S61_RS03190	COG3283	Transcriptional regulator of aromatic amino acids metabolism
H6S61_RS03195	COG3768	UPF0283 membrane protein
H6S61_RS03200	COG3106	COG3106 Predicted ATPase
H6S61_RS03220	COG2205	protein histidine kinase activity
H6S61_RS03220	COG0784	Response regulator, receiver
H6S61_RS03230	COG0494	nUDIX hydrolase
H6S61_RS03235	COG0814	amino acid
H6S61_RS03240	COG1760	l-serine dehydratase
H6S61_RS03255	COG0720	synthase
H6S61_RS03260	COG0840	transmembrane signaling receptor activity
H6S61_RS03265	COG0017	Asparaginyl-tRNA synthetase
H6S61_RS03275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6S61_RS03290	COG2770	Histidine kinase
H6S61_RS03290	COG3437	response regulator, receiver
H6S61_RS03295	COG1448	Aminotransferase
H6S61_RS03315	COG0840	transmembrane signaling receptor activity
H6S61_RS03320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H6S61_RS03325	COG1846	Transcriptional regulator
H6S61_RS03350	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H6S61_RS03365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H6S61_RS03370	COG3108	Peptidase M15
H6S61_RS03375	COG2989	Protein conserved in bacteria
H6S61_RS03405	COG2186	Transcriptional regulator
H6S61_RS03410	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H6S61_RS03420	COG0653	protein targeting
H6S61_RS03435	COG0366	Alpha amylase catalytic
H6S61_RS03445	COG4120	Belongs to the binding-protein-dependent transport system permease family
H6S61_RS03455	COG3092	negative regulation of chromosome organization
H6S61_RS03460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H6S61_RS03465	COG0280	phosphate acetyltransferase
H6S61_RS03465	COG0857	belongs to the CobB CobQ family
H6S61_RS03475	COG0583	DNA-binding transcription factor activity
H6S61_RS03500	COG1032	radical SAM domain protein
H6S61_RS03520	COG2207	Transcriptional regulator
H6S61_RS03555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_RS03570	COG0861	Integral membrane protein TerC family
H6S61_RS03575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H6S61_RS03580	COG1454	alcohol dehydrogenase
H6S61_RS03585	COG0235	Class ii aldolase
H6S61_RS03590	COG4154	Belongs to the RbsD FucU family
H6S61_RS03595	COG1070	Carbohydrate kinase
H6S61_RS03600	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
H6S61_RS03605	COG0738	Major facilitator superfamily
H6S61_RS03610	COG1349	DNA-binding transcription factor activity
H6S61_RS03615	COG0840	transmembrane signaling receptor activity
H6S61_RS03620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H6S61_RS03635	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H6S61_RS03650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H6S61_RS03660	COG0732	type I restriction modification DNA specificity domain
H6S61_RS03665	COG4804	nuclease activity
H6S61_RS03670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H6S61_RS03715	COG2205	protein histidine kinase activity
H6S61_RS03715	COG0784	Response regulator, receiver
H6S61_RS03725	COG0754	glutathionylspermidine amidase activity
H6S61_RS03735	COG3766	membrane
H6S61_RS03745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H6S61_RS03750	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H6S61_RS03755	COG2885	chlorophyll binding
H6S61_RS03760	COG0823	Involved in the tonB-independent uptake of proteins
H6S61_RS03775	COG0811	peptide transport
H6S61_RS03780	COG0824	Thioesterase
H6S61_RS03790	COG4890	Cyd operon protein YbgT
H6S61_RS03795	COG1294	oxidase, subunit
H6S61_RS03800	COG1271	oxidase subunit
H6S61_RS03805	COG2255	four-way junction helicase activity
H6S61_RS03810	COG0632	four-way junction helicase activity
H6S61_RS03830	COG4106	trans-aconitate 2-methyltransferase activity
H6S61_RS03835	COG0500	methyltransferase
H6S61_RS03840	COG0189	ligase activity
H6S61_RS03840	COG4067	protein conserved in archaea
H6S61_RS03870	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H6S61_RS03875	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H6S61_RS03880	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H6S61_RS03885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H6S61_RS03890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H6S61_RS03895	COG0745	RESPONSE REGULATOR receiver
H6S61_RS03905	COG1609	Transcriptional regulator
H6S61_RS03910	COG3070	regulator of competence-specific genes
H6S61_RS03935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H6S61_RS03940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H6S61_RS03950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H6S61_RS03965	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H6S61_RS03970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H6S61_RS03975	COG0542	response to heat
H6S61_RS03980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H6S61_RS03985	COG1278	Cold shock
H6S61_RS04005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H6S61_RS04010	COG1199	ATP-dependent helicase activity
H6S61_RS04015	COG0730	response to heat
H6S61_RS04020	COG3923	Primosomal replication protein n
H6S61_RS04035	COG0708	Exodeoxyribonuclease III
H6S61_RS04075	COG1882	Formate acetyltransferase
H6S61_RS04090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H6S61_RS04100	COG3013	Belongs to the UPF0304 family
H6S61_RS04105	COG2766	serine protein kinase
H6S61_RS04110	COG2718	Belongs to the UPF0229 family
H6S61_RS04115	COG2719	SpoVR family
H6S61_RS04120	COG2199	diguanylate cyclase activity
H6S61_RS04125	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H6S61_RS04130	COG2835	tetraacyldisaccharide 4'-kinase activity
H6S61_RS04135	COG1663	tetraacyldisaccharide 4'-kinase activity
H6S61_RS04145	COG2333	competence protein COMEC
H6S61_RS04145	COG0658	competence protein
H6S61_RS04155	COG4591	ABC-type transport system involved in lipoprotein release permease component
H6S61_RS04160	COG1136	(ABC) transporter
H6S61_RS04165	COG4591	ABC-type transport system involved in lipoprotein release permease component
H6S61_RS04175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H6S61_RS04190	COG1252	NADH dehydrogenase
H6S61_RS04220	COG0537	adenosine 5'-monophosphoramidase activity
H6S61_RS04245	COG0517	IMP dehydrogenase activity
H6S61_RS04245	COG0617	tRNA 3'-terminal CCA addition
H6S61_RS04245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H6S61_RS04250	COG3706	GGDEF domain
H6S61_RS04255	COG1982	Orn Lys Arg decarboxylase major
H6S61_RS04260	COG0531	amino acid
H6S61_RS04265	COG3710	Transcriptional regulator
H6S61_RS04280	COG2199	diguanylate cyclase activity
H6S61_RS04280	COG2203	Gaf domain
H6S61_RS04285	COG2239	Acts as a magnesium transporter
H6S61_RS04295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H6S61_RS04300	COG2226	methyltransferase
H6S61_RS04315	COG1785	Belongs to the alkaline phosphatase family
H6S61_RS04325	COG0346	lactoylglutathione lyase activity
H6S61_RS04335	COG2983	Belongs to the UPF0260 family
H6S61_RS04350	COG0745	RESPONSE REGULATOR receiver
H6S61_RS04355	COG2205	protein histidine kinase activity
H6S61_RS04370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H6S61_RS04375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H6S61_RS04385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H6S61_RS04390	COG2832	Protein of unknown function (DUF454)
H6S61_RS04395	COG0745	RESPONSE REGULATOR receiver
H6S61_RS04400	COG0583	DNA-binding transcription factor activity
H6S61_RS04405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H6S61_RS04410	COG1286	toxin biosynthetic process
H6S61_RS04415	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H6S61_RS04420	COG0285	dihydrofolate synthase activity
H6S61_RS04425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H6S61_RS04430	COG0101	tRNA pseudouridine synthase activity
H6S61_RS04440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H6S61_RS04450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H6S61_RS04465	COG3101	peptidyl-lysine hydroxylation
H6S61_RS04470	COG2860	membrane
H6S61_RS04480	COG2890	protein-(glutamine-N5) methyltransferase activity
H6S61_RS04485	COG2840	Smr protein MutS2
H6S61_RS04490	COG2062	phosphohistidine phosphatase, SixA
H6S61_RS04495	COG1025	Belongs to the peptidase M16 family
H6S61_RS04520	COG2067	long-chain fatty acid transport protein
H6S61_RS04525	COG2067	long-chain fatty acid transport protein
H6S61_RS04530	COG2853	Lipoprotein
H6S61_RS04540	COG3088	subunit of a heme lyase
H6S61_RS04540	COG4235	cytochrome complex assembly
H6S61_RS04545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H6S61_RS04550	COG1138	Cytochrome C-type biogenesis protein
H6S61_RS04555	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H6S61_RS04560	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H6S61_RS04565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H6S61_RS04570	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H6S61_RS04575	COG4133	protoheme IX ABC transporter activity
H6S61_RS04585	COG0835	chemotaxis
H6S61_RS04595	COG1192	Involved in chromosome partitioning
H6S61_RS04605	COG0784	Response regulator, receiver
H6S61_RS04605	COG0643	Histidine kinase
H6S61_RS04605	COG2198	Histidine kinase
H6S61_RS04610	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H6S61_RS04645	COG1684	flagellar biosynthetic protein fliR
H6S61_RS04650	COG1987	bacterial-type flagellum assembly
H6S61_RS04700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H6S61_RS04710	COG1677	Flagellar hook-basal body complex protein FliE
H6S61_RS04730	COG1516	flagellar protein fliS
H6S61_RS04740	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H6S61_RS04745	COG1334	flagellar protein FlaG
H6S61_RS04750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_RS04755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_RS04760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_RS04765	COG2837	iron assimilation
H6S61_RS04790	COG1393	Belongs to the ArsC family
H6S61_RS04800	COG1876	peptidase activity
H6S61_RS04810	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H6S61_RS04815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6S61_RS04820	COG2716	regulation of RNA biosynthetic process
H6S61_RS04825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H6S61_RS04840	COG4783	chaperone-mediated protein folding
H6S61_RS04845	COG1393	Belongs to the ArsC family
H6S61_RS04865	COG2233	PERMEase
H6S61_RS04870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H6S61_RS04875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H6S61_RS04880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H6S61_RS04885	COG0121	glutamine amidotransferase
H6S61_RS04895	COG1960	acyl-CoA dehydrogenase activity
H6S61_RS04925	COG0328	RNA-DNA hybrid ribonuclease activity
H6S61_RS04930	COG2226	methyltransferase
H6S61_RS04935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H6S61_RS04940	COG1388	LysM domain
H6S61_RS04940	COG0741	lytic transglycosylase activity
H6S61_RS04955	COG0347	Belongs to the P(II) protein family
H6S61_RS04970	COG0825	malonyl-CoA metabolic process
H6S61_RS04975	COG0587	DNA-directed DNA polymerase activity
H6S61_RS04980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H6S61_RS04985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6S61_RS04990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6S61_RS04995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H6S61_RS05005	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H6S61_RS05010	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6S61_RS05015	COG0750	zinc metalloprotease
H6S61_RS05025	COG0575	Belongs to the CDS family
H6S61_RS05030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H6S61_RS05035	COG0233	cytoplasmic translational termination
H6S61_RS05040	COG0528	UMP kinase activity
H6S61_RS05045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H6S61_RS05050	COG0052	Belongs to the universal ribosomal protein uS2 family
H6S61_RS05055	COG0024	Methionine aminopeptidase
H6S61_RS05060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H6S61_RS05100	COG1671	Belongs to the UPF0178 family
H6S61_RS05105	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H6S61_RS05115	COG0254	rRNA binding
H6S61_RS05120	COG1720	tRNA m6t6A37 methyltransferase activity
H6S61_RS05145	COG0733	neurotransmitter:sodium symporter activity
H6S61_RS05160	COG0514	ATP-dependent DNA helicase (RecQ)
H6S61_RS05165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H6S61_RS05180	COG1477	protein flavinylation
H6S61_RS05185	COG2871	sodium ion transport
H6S61_RS05190	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H6S61_RS05200	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H6S61_RS05205	COG1805	sodium ion transport
H6S61_RS05210	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H6S61_RS05215	COG0271	Belongs to the BolA IbaG family
H6S61_RS05220	COG2813	Specifically methylates the guanine in position
H6S61_RS05235	COG2211	Major facilitator Superfamily
H6S61_RS05245	COG1595	DNA-templated transcription, initiation
H6S61_RS05255	COG3248	Nucleoside-binding outer membrane protein
H6S61_RS05260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H6S61_RS05265	COG0693	protein deglycase activity
H6S61_RS05270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H6S61_RS05280	COG2166	iron-sulfur cluster assembly
H6S61_RS05285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H6S61_RS05290	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H6S61_RS05310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H6S61_RS05315	COG1074	ATP-dependent DNA helicase activity
H6S61_RS05320	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H6S61_RS05325	COG3083	sulfuric ester hydrolase activity
H6S61_RS05340	COG3141	response to X-ray
H6S61_RS05345	COG2171	N-acyltransferase activity
H6S61_RS05350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H6S61_RS05355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H6S61_RS05360	COG1349	DNA-binding transcription factor activity
H6S61_RS05365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H6S61_RS05380	COG0189	ligase activity
H6S61_RS05380	COG0569	domain protein
H6S61_RS05395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6S61_RS05405	COG0840	transmembrane signaling receptor activity
H6S61_RS05410	COG2017	converts alpha-aldose to the beta-anomer
H6S61_RS05420	COG1085	galactose-1-phosphate uridylyltransferase
H6S61_RS05425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H6S61_RS05430	COG1609	Transcriptional regulator
H6S61_RS05440	COG3250	beta-galactosidase activity
H6S61_RS05445	COG2731	YhcH YjgK YiaL family protein
H6S61_RS05450	COG0531	amino acid
H6S61_RS05455	COG0531	amino acid
H6S61_RS05470	COG0583	DNA-binding transcription factor activity
H6S61_RS05475	COG2059	Chromate
H6S61_RS05525	COG4964	Belongs to the GSP D family
H6S61_RS05560	COG1022	Amp-dependent synthetase and ligase
H6S61_RS05565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H6S61_RS05585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H6S61_RS05595	COG0560	Phosphoserine phosphatase
H6S61_RS05605	COG0813	purine-nucleoside phosphorylase activity
H6S61_RS05610	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H6S61_RS05615	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H6S61_RS05620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H6S61_RS05625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H6S61_RS05630	COG0084	hydrolase, TatD family'
H6S61_RS05645	COG3706	GGDEF domain
H6S61_RS05655	COG0456	acetyltransferase
H6S61_RS05665	COG3153	acetyltransferase
H6S61_RS05670	COG3154	lipid carrier protein
H6S61_RS05680	COG0826	peptidase U32
H6S61_RS05685	COG0826	peptidase U32
H6S61_RS05690	COG0534	Mate efflux family protein
H6S61_RS05705	COG1185	polyribonucleotide nucleotidyltransferase activity
H6S61_RS05735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H6S61_RS05740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H6S61_RS05745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H6S61_RS05755	COG0195	Participates in both transcription termination and antitermination
H6S61_RS05760	COG0779	Required for maturation of 30S ribosomal subunits
H6S61_RS05775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H6S61_RS05780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H6S61_RS05785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H6S61_RS05790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H6S61_RS05795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H6S61_RS05800	COG1534	Rna-binding protein
H6S61_RS05815	COG2027	D-alanyl-D-alanine carboxypeptidase
H6S61_RS05820	COG2832	Protein of unknown function (DUF454)
H6S61_RS05825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H6S61_RS05830	COG0739	heme binding
H6S61_RS05855	COG0628	permease
H6S61_RS05865	COG0784	Response regulator, receiver
H6S61_RS05865	COG2205	protein histidine kinase activity
H6S61_RS05875	COG0601	transmembrane transport
H6S61_RS05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6S61_RS05885	COG0444	Belongs to the ABC transporter superfamily
H6S61_RS05890	COG4608	Belongs to the ABC transporter superfamily
H6S61_RS05900	COG2971	BadF BadG BcrA BcrD
H6S61_RS05915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H6S61_RS05920	COG3842	ATPase activity
H6S61_RS05930	COG1840	ABC-type Fe3 transport system, periplasmic component
H6S61_RS05935	COG0004	ammonium transporteR
H6S61_RS05940	COG0347	Belongs to the P(II) protein family
H6S61_RS05945	COG3112	Uncharacterised protein family (UPF0231)
H6S61_RS05950	COG3835	regulator
H6S61_RS05955	COG2610	gluconate transmembrane transporter activity
H6S61_RS05960	COG1929	Belongs to the glycerate kinase type-1 family
H6S61_RS05965	COG1049	propionate catabolic process, 2-methylcitrate cycle
H6S61_RS05970	COG1752	Esterase of the alpha-beta hydrolase superfamily
H6S61_RS05975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H6S61_RS05980	COG1643	Atp-dependent helicase
H6S61_RS05985	COG1489	DNA binding
H6S61_RS05990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H6S61_RS05995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6S61_RS06005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H6S61_RS06010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H6S61_RS06020	COG0842	Transport permease protein
H6S61_RS06025	COG1131	(ABC) transporter
H6S61_RS06030	COG0659	secondary active sulfate transmembrane transporter activity
H6S61_RS06035	COG0288	reversible hydration of carbon dioxide
H6S61_RS06050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H6S61_RS06055	COG0508	dehydrogenase complex catalyzes the overall conversion of
H6S61_RS06060	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H6S61_RS06065	COG2186	Transcriptional regulator
H6S61_RS06070	COG3023	N-Acetylmuramoyl-L-alanine amidase
H6S61_RS06080	COG4969	Belongs to the N-Me-Phe pilin family
H6S61_RS06085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6S61_RS06090	COG1459	type II secretion system
H6S61_RS06100	COG0237	dephospho-CoA kinase activity
H6S61_RS06110	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H6S61_RS06115	COG0335	large ribosomal subunit rRNA binding
H6S61_RS06120	COG0336	Belongs to the RNA methyltransferase TrmD family
H6S61_RS06125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H6S61_RS06130	COG0228	four-way junction DNA binding
H6S61_RS06135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H6S61_RS06140	COG4137	Cytochrome C assembly protein
H6S61_RS06145	COG4536	flavin adenine dinucleotide binding
H6S61_RS06150	COG1854	S-ribosylhomocysteine lyase activity
H6S61_RS06165	COG0612	Peptidase, M16
H6S61_RS06170	COG1238	metal cluster binding
H6S61_RS06180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H6S61_RS06190	COG3630	sodium ion export across plasma membrane
H6S61_RS06235	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H6S61_RS06240	COG0527	aspartate kinase activity
H6S61_RS06245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H6S61_RS06255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H6S61_RS06265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H6S61_RS06270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H6S61_RS06275	COG1388	LysM domain
H6S61_RS06275	COG4942	peptidase
H6S61_RS06280	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H6S61_RS06290	COG0585	pseudouridine synthase activity
H6S61_RS06295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H6S61_RS06305	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H6S61_RS06315	COG0504	CTP synthase activity
H6S61_RS06320	COG3956	TIGRFAM MazG family protein
H6S61_RS06325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H6S61_RS06330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H6S61_RS06355	COG0736	holo-[acyl-carrier-protein] synthase activity
H6S61_RS06360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H6S61_RS06365	COG1381	Involved in DNA repair and RecF pathway recombination
H6S61_RS06370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H6S61_RS06385	COG0481	GTPase activity
H6S61_RS06390	COG3086	response to oxidative stress
H6S61_RS06405	COG1595	DNA-templated transcription, initiation
H6S61_RS06410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H6S61_RS06425	COG0354	folic acid binding
H6S61_RS06440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6S61_RS06445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6S61_RS06450	COG3079	Belongs to the UPF0149 family
H6S61_RS06455	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H6S61_RS06465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H6S61_RS06475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H6S61_RS06490	COG1279	arginine transmembrane transporter activity
H6S61_RS06495	COG0668	transmembrane transport
H6S61_RS06500	COG0191	fructose-bisphosphate aldolase activity
H6S61_RS06505	COG0126	phosphoglycerate kinase activity
H6S61_RS06510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H6S61_RS06520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H6S61_RS06525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H6S61_RS06540	COG2356	endonuclease I
H6S61_RS06550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H6S61_RS06560	COG1678	Uncharacterized ACR, COG1678
H6S61_RS06565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H6S61_RS06580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H6S61_RS06585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H6S61_RS06590	COG0762	integral membrane protein
H6S61_RS06605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H6S61_RS06610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H6S61_RS06615	COG2066	Belongs to the glutaminase family
H6S61_RS06620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H6S61_RS06630	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H6S61_RS06635	COG0741	lytic transglycosylase activity
H6S61_RS06750	COG1609	Transcriptional regulator
H6S61_RS06755	COG3394	polysaccharide catabolic process
H6S61_RS06760	COG1486	melibiose metabolic process
H6S61_RS06765	COG1447	Phosphotransferase system cellobiose-specific component IIA
H6S61_RS06775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H6S61_RS06780	COG0726	polysaccharide deacetylase
H6S61_RS06840	COG2378	regulation of single-species biofilm formation
H6S61_RS06860	COG4974	Belongs to the 'phage' integrase family
H6S61_RS06885	COG0795	lipopolysaccharide-transporting ATPase activity
H6S61_RS06890	COG0795	lipopolysaccharide-transporting ATPase activity
H6S61_RS06895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H6S61_RS06900	COG2927	DNA polymerase III (CHI subunit)
H6S61_RS06905	COG0525	valine-tRNA ligase activity
H6S61_RS06915	COG4269	membrane
H6S61_RS06925	COG0456	acetyltransferase
H6S61_RS06960	COG0251	oxidation-reduction process
H6S61_RS06965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H6S61_RS06975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H6S61_RS06980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H6S61_RS06985	COG0312	modulator of DNA gyrase
H6S61_RS06990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H6S61_RS06995	COG3164	Protein of unknown function
H6S61_RS07005	COG0424	maF-like protein
H6S61_RS07010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H6S61_RS07015	COG1792	Involved in formation and maintenance of cell shape
H6S61_RS07020	COG1077	Cell shape determining protein MreB Mrl
H6S61_RS07050	COG2165	general secretion pathway protein
H6S61_RS07055	COG2165	general secretion pathway protein
H6S61_RS07065	COG1459	type II secretion system
H6S61_RS07070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6S61_RS07080	COG3409	Peptidoglycan-binding domain 1 protein
H6S61_RS07080	COG3267	Type II secretory pathway component ExeA
H6S61_RS07105	COG2199	diguanylate cyclase activity
H6S61_RS07105	COG2200	EAL domain
H6S61_RS07125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H6S61_RS07135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H6S61_RS07140	COG0527	aspartate kinase activity
H6S61_RS07145	COG0646	methionine synthase
H6S61_RS07145	COG1410	methionine synthase
H6S61_RS07240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H6S61_RS07270	COG0735	belongs to the Fur family
H6S61_RS07285	COG0432	Pfam Uncharacterised protein family UPF0047
H6S61_RS07295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H6S61_RS07310	COG0359	binds to the 23S rRNA
H6S61_RS07320	COG2965	DNA replication, synthesis of RNA primer
H6S61_RS07325	COG0360	Binds together with S18 to 16S ribosomal RNA
H6S61_RS07330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H6S61_RS07335	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H6S61_RS07345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H6S61_RS07350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H6S61_RS07380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H6S61_RS07395	COG0165	Argininosuccinate lyase
H6S61_RS07395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H6S61_RS07400	COG0137	argininosuccinate synthase activity
H6S61_RS07410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H6S61_RS07415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H6S61_RS07420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H6S61_RS07430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H6S61_RS07435	COG0460	homoserine dehydrogenase
H6S61_RS07435	COG0527	aspartate kinase activity
H6S61_RS07440	COG0626	cystathionine gamma-synthase activity
H6S61_RS07445	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
H6S61_RS07450	COG0281	malic enzyme
H6S61_RS07455	COG0254	rRNA binding
H6S61_RS07460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H6S61_RS07465	COG1609	Transcriptional regulator
H6S61_RS07475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H6S61_RS07480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H6S61_RS07485	COG1575	Belongs to the MenA family. Type 1 subfamily
H6S61_RS07495	COG3074	FtsZ-dependent cytokinesis
H6S61_RS07500	COG1494	fructose-1,6-bisphosphatase
H6S61_RS07525	COG0149	triose-phosphate isomerase activity
H6S61_RS07530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H6S61_RS07540	COG2906	2 iron, 2 sulfur cluster binding
H6S61_RS07550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H6S61_RS07555	COG0049	tRNA binding
H6S61_RS07560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H6S61_RS07575	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H6S61_RS07580	COG2964	Protein conserved in bacteria
H6S61_RS07585	COG0545	Peptidyl-prolyl cis-trans isomerase
H6S61_RS07595	COG2900	Belongs to the SlyX family
H6S61_RS07605	COG1047	Peptidyl-prolyl cis-trans
H6S61_RS07620	COG2249	NAD(P)H dehydrogenase (quinone) activity
H6S61_RS07625	COG0488	(ABC) transporter
H6S61_RS07640	COG3089	Belongs to the UPF0270 family
H6S61_RS07645	COG3954	Phosphoribulokinase
H6S61_RS07650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6S61_RS07660	COG1012	belongs to the aldehyde dehydrogenase family
H6S61_RS07670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H6S61_RS07690	COG0180	Tryptophanyl-tRNA synthetase
H6S61_RS07695	COG0546	phosphoglycolate phosphatase activity
H6S61_RS07700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H6S61_RS07705	COG0557	exoribonuclease II activity
H6S61_RS07710	COG0402	S-adenosylhomocysteine deaminase activity
H6S61_RS07715	COG1959	2 iron, 2 sulfur cluster binding
H6S61_RS07725	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H6S61_RS07735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H6S61_RS07740	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H6S61_RS07745	COG0330	HflC and HflK could
H6S61_RS07750	COG0330	HflC and HflK could
H6S61_RS07755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H6S61_RS07760	COG1923	regulation of RNA biosynthetic process
H6S61_RS07770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H6S61_RS07775	COG0860	N-Acetylmuramoyl-L-alanine amidase
H6S61_RS07780	COG0802	atpase or kinase
H6S61_RS07785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H6S61_RS07845	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H6S61_RS07850	COG1162	GTPase activity
H6S61_RS07855	COG0688	phosphatidylethanolamine metabolic process
H6S61_RS07860	COG0471	metal ion transport
H6S61_RS07870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H6S61_RS07875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H6S61_RS07880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H6S61_RS07885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H6S61_RS07890	COG1045	serine acetyltransferase
H6S61_RS07895	COG4942	peptidase
H6S61_RS07915	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H6S61_RS07920	COG1053	succinate dehydrogenase
H6S61_RS07925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H6S61_RS07930	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H6S61_RS07935	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H6S61_RS07945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H6S61_RS07950	COG1509	lysine 2,3-aminomutase activity
H6S61_RS07955	COG1285	pathogenesis
H6S61_RS07965	COG0459	protein refolding
H6S61_RS07970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H6S61_RS07975	COG0534	Mate efflux family protein
H6S61_RS07980	COG0205	6-phosphofructokinase activity
H6S61_RS07990	COG3678	ATP-independent chaperone mediated protein folding
H6S61_RS07995	COG0745	RESPONSE REGULATOR receiver
H6S61_RS08000	COG2205	protein histidine kinase activity
H6S61_RS08005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H6S61_RS08010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H6S61_RS08020	COG1027	Aspartate ammonia-lyase
H6S61_RS08025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H6S61_RS08030	COG4232	protein-disulfide reductase activity
H6S61_RS08040	COG2095	MarC family integral membrane protein
H6S61_RS08050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H6S61_RS08065	COG0784	Response regulator, receiver
H6S61_RS08065	COG2205	protein histidine kinase activity
H6S61_RS08065	COG2198	Histidine kinase
H6S61_RS08070	COG2814	Major facilitator Superfamily
H6S61_RS08085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H6S61_RS08090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H6S61_RS08095	COG0511	ligase activity, forming carbon-carbon bonds
H6S61_RS08100	COG0439	Biotin carboxylase
H6S61_RS08105	COG2264	protein methyltransferase activity
H6S61_RS08115	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H6S61_RS08120	COG0840	transmembrane signaling receptor activity
H6S61_RS08125	COG0789	Transcriptional regulator
H6S61_RS08130	COG0138	bifunctional purine biosynthesis protein purh
H6S61_RS08150	COG1253	flavin adenine dinucleotide binding
H6S61_RS08155	COG3068	Protein conserved in bacteria
H6S61_RS08160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H6S61_RS08165	COG1573	uracil-dna glycosylase
H6S61_RS08175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H6S61_RS08195	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H6S61_RS08200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H6S61_RS08205	COG0085	RNA polymerase activity
H6S61_RS08210	COG0222	ribosome binding
H6S61_RS08215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H6S61_RS08220	COG0081	regulation of translation
H6S61_RS08235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H6S61_RS08240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H6S61_RS08275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H6S61_RS08285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6S61_RS08370	COG3118	belongs to the thioredoxin family
H6S61_RS08380	COG0248	Ppx GppA phosphatase
H6S61_RS08385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H6S61_RS08395	COG0514	ATP-dependent DNA helicase (RecQ)
H6S61_RS08400	COG2962	Rard protein
H6S61_RS08410	COG1280	lysine exporter protein (LysE YggA)
H6S61_RS08415	COG0210	DNA helicase
H6S61_RS08455	COG0006	proline dipeptidase activity
H6S61_RS08455	COG0006	proline dipeptidase activity
H6S61_RS08465	COG2022	thiamine diphosphate biosynthetic process
H6S61_RS08475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H6S61_RS08485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H6S61_RS08490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H6S61_RS08495	COG2132	Multicopper oxidase
H6S61_RS08540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H6S61_RS08550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H6S61_RS08555	COG0408	coproporphyrinogen oxidase activity
H6S61_RS08560	COG0009	L-threonylcarbamoyladenylate synthase
H6S61_RS08565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H6S61_RS08575	COG0551	DNA topoisomerase type I activity
H6S61_RS08580	COG2922	Belongs to the Smg family
H6S61_RS08585	COG0758	DNA mediated transformation
H6S61_RS08595	COG0242	peptide deformylase activity
H6S61_RS08600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H6S61_RS08605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H6S61_RS08605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H6S61_RS08610	COG0569	domain protein
H6S61_RS08615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H6S61_RS08620	COG1272	protein, Hemolysin III
H6S61_RS08625	COG4326	sporulation control protein
H6S61_RS08635	COG3084	Protein conserved in bacteria
H6S61_RS08645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H6S61_RS08650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H6S61_RS08655	COG0204	Acyl-transferase
H6S61_RS08665	COG0606	chelatase, subunit chli
H6S61_RS08675	COG3978	acetolactate synthase activity
H6S61_RS08680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H6S61_RS08685	COG0129	dihydroxy-acid dehydratase activity
H6S61_RS08695	COG0583	DNA-binding transcription factor activity
H6S61_RS08700	COG2814	Major facilitator Superfamily
H6S61_RS08710	COG0765	amino acid transport
H6S61_RS08720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H6S61_RS08725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H6S61_RS08730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H6S61_RS08735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H6S61_RS08740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H6S61_RS08745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H6S61_RS08755	COG0356	it plays a direct role in the translocation of protons across the membrane
H6S61_RS08760	COG3312	ion transport
H6S61_RS08765	COG1475	DNA binding
H6S61_RS08770	COG1192	Involved in chromosome partitioning
H6S61_RS08775	COG0357	Ribosomal RNA small subunit methyltransferase G
H6S61_RS08780	COG0445	tRNA wobble uridine modification
H6S61_RS08785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H6S61_RS08795	COG0706	membrane insertase activity
H6S61_RS08805	COG0594	ribonuclease P activity
H6S61_RS08810	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H6S61_RS08815	COG1126	abc transporter atp-binding protein
H6S61_RS08835	COG0592	DNA-directed DNA polymerase activity
H6S61_RS08845	COG0187	DNA topoisomerase II activity
H6S61_RS08850	COG0071	Belongs to the small heat shock protein (HSP20) family
H6S61_RS08860	COG3977	Valine--pyruvate aminotransferase
H6S61_RS08870	COG0751	glycine-tRNA ligase activity
H6S61_RS08875	COG0752	glycyl-tRNA synthetase alpha subunit
H6S61_RS08880	COG2119	membrane
H6S61_RS08890	COG0425	Belongs to the sulfur carrier protein TusA family
H6S61_RS08905	COG0604	alcohol dehydrogenase
H6S61_RS08910	COG0183	Belongs to the thiolase family
H6S61_RS08920	COG1739	Uncharacterized protein family UPF0029
H6S61_RS08925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H6S61_RS08930	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H6S61_RS08970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H6S61_RS08975	COG2960	long-chain fatty acid transporting porin activity
H6S61_RS08980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_RS08985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H6S61_RS08990	COG1309	transcriptional regulator
H6S61_RS09030	COG4172	Belongs to the ABC transporter superfamily
H6S61_RS09035	COG4166	transmembrane transport
H6S61_RS09040	COG0601	transmembrane transport
H6S61_RS09045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6S61_RS09080	COG0515	serine threonine protein kinase
H6S61_RS09080	COG2815	serine threonine protein kinase
H6S61_RS09090	COG0745	RESPONSE REGULATOR receiver
H6S61_RS09095	COG1609	Transcriptional regulator
H6S61_RS09100	COG0129	dihydroxy-acid dehydratase activity
H6S61_RS09105	COG3265	gluconokinase activity
H6S61_RS09110	COG2610	gluconate transmembrane transporter activity
H6S61_RS09115	COG0800	Aldolase
H6S61_RS09120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H6S61_RS09125	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H6S61_RS09135	COG1522	sequence-specific DNA binding
H6S61_RS09140	COG5002	protein histidine kinase activity
H6S61_RS09140	COG5001	Diguanylate cyclase
H6S61_RS09145	COG0742	ribosomal rna small subunit methyltransferase
H6S61_RS09160	COG0589	response to stress
H6S61_RS09165	COG1528	Iron-storage protein
H6S61_RS09175	COG2081	HI0933 family
H6S61_RS09185	COG2959	enzyme of heme biosynthesis
H6S61_RS09195	COG0181	hydroxymethylbilane synthase activity
H6S61_RS09200	COG3072	Adenylate cyclase
H6S61_RS09205	COG1965	Belongs to the frataxin family
H6S61_RS09215	COG0019	diaminopimelate decarboxylase activity
H6S61_RS09220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H6S61_RS09230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H6S61_RS09235	COG1011	Hydrolase
H6S61_RS09240	COG2199	diguanylate cyclase activity
H6S61_RS09240	COG3287	FIST C domain
H6S61_RS09240	COG2200	EAL domain
H6S61_RS09245	COG3148	PFAM DTW domain containing protein
H6S61_RS09260	COG0561	phosphatase activity
H6S61_RS09265	COG2267	carboxylic ester hydrolase activity
H6S61_RS09270	COG1280	lysine exporter protein (LysE YggA)
H6S61_RS09275	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H6S61_RS09280	COG0640	Transcriptional regulator
H6S61_RS09285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H6S61_RS09325	COG2095	MarC family integral membrane protein
H6S61_RS09335	COG0742	ribosomal rna small subunit methyltransferase
H6S61_RS09340	COG0552	protein localization to endoplasmic reticulum
H6S61_RS09345	COG2884	Cell division ATP-binding protein ftsE
H6S61_RS09350	COG2177	Part of the ABC transporter FtsEX involved in
H6S61_RS09360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H6S61_RS09365	COG0705	Rhomboid family
H6S61_RS09370	COG1580	Controls the rotational direction of flagella during chemotaxis
H6S61_RS09375	COG3161	chorismate lyase activity
H6S61_RS09385	COG2937	Belongs to the GPAT DAPAT family
H6S61_RS09390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H6S61_RS09400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H6S61_RS09420	COG4206	TonB-dependent receptor
H6S61_RS09500	COG3344	reverse transcriptase
H6S61_RS09520	COG1322	Protein conserved in bacteria
H6S61_RS09525	COG2226	methyltransferase
H6S61_RS09530	COG3165	ubiquinone biosynthetic process from chorismate
H6S61_RS09540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H6S61_RS09545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H6S61_RS09550	COG0805	protein transport
H6S61_RS09555	COG0084	hydrolase, TatD family'
H6S61_RS09565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6S61_RS09565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6S61_RS09570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H6S61_RS09600	COG5001	Diguanylate cyclase
H6S61_RS09600	COG3300	MHYT domain
H6S61_RS09610	COG3852	Histidine kinase
H6S61_RS09620	COG0174	glutamine synthetase
H6S61_RS09625	COG1217	gtp-binding protein TYPA
H6S61_RS09640	COG1295	ribonuclease BN
H6S61_RS09645	COG1490	D-aminoacyl-tRNA deacylase activity
H6S61_RS09650	COG0456	acetyltransferase
H6S61_RS09665	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H6S61_RS09670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H6S61_RS09675	COG3031	protein transport across the cell outer membrane
H6S61_RS09685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6S61_RS09690	COG1459	type II secretion system
H6S61_RS09695	COG2165	general secretion pathway protein
H6S61_RS09700	COG2165	general secretion pathway protein
H6S61_RS09705	COG2165	general secretion pathway protein
H6S61_RS09710	COG4795	General secretion pathway protein
H6S61_RS09715	COG3156	type II secretion system protein K
H6S61_RS09720	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H6S61_RS09725	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H6S61_RS09735	COG1218	3'(2'),5'-bisphosphate nucleotidase
H6S61_RS09740	COG0494	nUDIX hydrolase
H6S61_RS09745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H6S61_RS09745	COG0316	Belongs to the HesB IscA family
H6S61_RS09755	COG0596	Alpha beta hydrolase
H6S61_RS09765	COG3344	reverse transcriptase
H6S61_RS09770	COG2183	response to ionizing radiation
H6S61_RS09790	COG2233	PERMEase
H6S61_RS09795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H6S61_RS09800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H6S61_RS09805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H6S61_RS09810	COG1758	RNA polymerase activity
H6S61_RS09815	COG0194	GDP metabolic process
H6S61_RS09830	COG0848	biopolymer transport protein
H6S61_RS09835	COG0811	peptide transport
H6S61_RS09840	COG0811	peptide transport
H6S61_RS09850	COG4206	TonB-dependent receptor
H6S61_RS09855	COG4174	ABC transporter (Permease)
H6S61_RS09860	COG4239	(ABC) transporter, permease
H6S61_RS09865	COG0747	negative chemotaxis
H6S61_RS09870	COG0444	Belongs to the ABC transporter superfamily
H6S61_RS09875	COG4608	Belongs to the ABC transporter superfamily
H6S61_RS09890	COG0653	protein targeting
H6S61_RS09905	COG1561	YicC-like family, N-terminal region
H6S61_RS09910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H6S61_RS09920	COG1560	Kdo2-lipid A biosynthetic process
H6S61_RS09925	COG1309	transcriptional regulator
H6S61_RS09935	COG0840	transmembrane signaling receptor activity
H6S61_RS09940	COG2003	Belongs to the UPF0758 family
H6S61_RS09945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H6S61_RS09950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H6S61_RS09960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H6S61_RS09970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H6S61_RS09975	COG0859	PFAM glycosyl transferase family 9
H6S61_RS09980	COG0463	Glycosyl transferase, family 2
H6S61_RS09985	COG0859	PFAM glycosyl transferase family 9
H6S61_RS09990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H6S61_RS09995	COG3642	lipopolysaccharide core region biosynthetic process
H6S61_RS10000	COG3083	sulfuric ester hydrolase activity
H6S61_RS10015	COG1086	Polysaccharide biosynthesis protein
H6S61_RS10020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H6S61_RS10030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H6S61_RS10035	COG0107	imidazoleglycerol-phosphate synthase activity
H6S61_RS10040	COG1083	cytidylyl-transferase
H6S61_RS10050	COG2089	acid synthase
H6S61_RS10060	COG1519	Transferase
H6S61_RS10100	COG1596	polysaccharide export
H6S61_RS10140	COG2244	polysaccharide biosynthetic process
H6S61_RS10175	COG1215	transferase activity, transferring glycosyl groups
H6S61_RS10195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H6S61_RS10215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H6S61_RS10220	COG0088	Forms part of the polypeptide exit tunnel
H6S61_RS10225	COG0089	rRNA binding
H6S61_RS10230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H6S61_RS10235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H6S61_RS10245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H6S61_RS10250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H6S61_RS10255	COG0255	Belongs to the universal ribosomal protein uL29 family
H6S61_RS10260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H6S61_RS10265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H6S61_RS10270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H6S61_RS10275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H6S61_RS10280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H6S61_RS10285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H6S61_RS10290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H6S61_RS10295	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H6S61_RS10300	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H6S61_RS10305	COG1841	ribosomal large subunit assembly
H6S61_RS10310	COG0200	Binds to the 23S rRNA
H6S61_RS10315	COG0201	protein transport
H6S61_RS10320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H6S61_RS10325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H6S61_RS10330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H6S61_RS10335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H6S61_RS10340	COG0202	RNA polymerase activity
H6S61_RS10345	COG0203	ribosomal protein L17
H6S61_RS10355	COG0545	Peptidyl-prolyl cis-trans isomerase
H6S61_RS10360	COG3266	domain, Protein
H6S61_RS10360	COG3061	Opacity-associated protein A
H6S61_RS10370	COG2153	protein acetylation
H6S61_RS10380	COG0737	Belongs to the 5'-nucleotidase family
H6S61_RS10385	COG1648	precorrin-2 dehydrogenase activity
H6S61_RS10385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H6S61_RS10390	COG0175	sulfate reduction
H6S61_RS10395	COG2895	sulfate adenylyltransferase (ATP) activity
H6S61_RS10400	COG0471	metal ion transport
H6S61_RS10400	COG3273	potassium ion transport
H6S61_RS10405	COG0529	Catalyzes the synthesis of activated sulfate
H6S61_RS10425	COG0577	efflux transmembrane transporter activity
H6S61_RS10425	COG1136	(ABC) transporter
H6S61_RS10440	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H6S61_RS10455	COG0729	surface antigen
H6S61_RS10460	COG2911	Protein conserved in bacteria
H6S61_RS10465	COG2105	PFAM AIG2 family protein
H6S61_RS10475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H6S61_RS10480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H6S61_RS10485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H6S61_RS10490	COG0163	prenyltransferase activity
H6S61_RS10495	COG4143	(ABC) transporter
H6S61_RS10500	COG1178	ABC-type Fe3 transport system permease component
H6S61_RS10505	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H6S61_RS10510	COG3028	Belongs to the UPF0307 family
H6S61_RS10520	COG2239	Acts as a magnesium transporter
H6S61_RS10525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_RS10530	COG1660	Displays ATPase and GTPase activities
H6S61_RS10535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_RS10540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H6S61_RS10550	COG1137	ATPase activity
H6S61_RS10555	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H6S61_RS10565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H6S61_RS10570	COG0517	IMP dehydrogenase activity
H6S61_RS10570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H6S61_RS10580	COG1127	ABC transporter
H6S61_RS10585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H6S61_RS10590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H6S61_RS10595	COG2854	intermembrane phospholipid transfer
H6S61_RS10605	COG5007	Belongs to the BolA IbaG family
H6S61_RS10615	COG0204	Acyl-transferase
H6S61_RS10620	COG0589	response to stress
H6S61_RS10630	COG2358	TRAP transporter, solute receptor (TAXI family
H6S61_RS10635	COG1438	arginine binding
H6S61_RS10640	COG0039	L-malate dehydrogenase activity
H6S61_RS10645	COG0142	geranyltranstransferase activity
H6S61_RS10650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H6S61_RS10655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H6S61_RS10665	COG2966	Psort location CytoplasmicMembrane, score
H6S61_RS10670	COG3610	response to peptide
H6S61_RS10685	COG2967	ApaG domain
H6S61_RS10690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H6S61_RS10695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H6S61_RS10720	COG0066	3-isopropylmalate dehydratase activity
H6S61_RS10730	COG0473	3-isopropylmalate dehydrogenase activity
H6S61_RS10735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H6S61_RS10760	COG1022	Amp-dependent synthetase and ligase
H6S61_RS10765	COG0028	Belongs to the TPP enzyme family
H6S61_RS10770	COG0440	acetolactate synthase activity
H6S61_RS10775	COG3706	GGDEF domain
H6S61_RS10790	COG1349	DNA-binding transcription factor activity
H6S61_RS10795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H6S61_RS10800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H6S61_RS10815	COG3550	peptidyl-serine autophosphorylation
H6S61_RS10840	COG1610	YqeY-like protein
H6S61_RS10845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H6S61_RS10850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H6S61_RS10855	COG0596	Alpha beta hydrolase
H6S61_RS10865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H6S61_RS10870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H6S61_RS10875	COG1968	undecaprenyl-diphosphatase activity
H6S61_RS10880	COG0617	tRNA 3'-terminal CCA addition
H6S61_RS10885	COG3267	Type II secretory pathway component ExeA
H6S61_RS10885	COG3409	Peptidoglycan-binding domain 1 protein
H6S61_RS10890	COG4991	sh3 domain protein
H6S61_RS10895	COG0306	phosphate transporter
H6S61_RS10900	COG1392	Phosphate transport regulator
H6S61_RS10905	COG3025	triphosphatase activity
H6S61_RS10910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H6S61_RS10920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H6S61_RS10930	COG1538	Outer membrane efflux protein
H6S61_RS10935	COG0494	nUDIX hydrolase
H6S61_RS10940	COG3151	Protein conserved in bacteria
H6S61_RS10950	COG3150	esterase
H6S61_RS10965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6S61_RS10970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6S61_RS10975	COG3105	Protein conserved in bacteria
H6S61_RS10980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H6S61_RS10985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H6S61_RS10990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H6S61_RS10995	COG0723	plastoquinol--plastocyanin reductase activity
H6S61_RS11000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H6S61_RS11005	COG2857	Cytochrome c1
H6S61_RS11010	COG0625	glutathione transferase activity
H6S61_RS11015	COG2969	positive regulation of protein catabolic process
H6S61_RS11025	COG2823	Periplasmic or secreted lipoprotein
H6S61_RS11030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H6S61_RS11035	COG0792	nuclease activity
H6S61_RS11040	COG3107	peptidoglycan biosynthetic process
H6S61_RS11045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H6S61_RS11055	COG0275	rRNA processing
H6S61_RS11060	COG3116	cell division
H6S61_RS11065	COG0768	penicillin binding
H6S61_RS11075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H6S61_RS11080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H6S61_RS11090	COG0772	Belongs to the SEDS family
H6S61_RS11100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H6S61_RS11105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H6S61_RS11110	COG0849	cell division
H6S61_RS11115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H6S61_RS11120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H6S61_RS11130	COG0653	protein targeting
H6S61_RS11135	COG0494	nUDIX hydrolase
H6S61_RS11145	COG0505	Belongs to the CarA family
H6S61_RS11150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H6S61_RS11160	COG0730	response to heat
H6S61_RS11165	COG0583	DNA-binding transcription factor activity
H6S61_RS11170	COG2860	membrane
H6S61_RS11175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H6S61_RS11185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H6S61_RS11195	COG0493	'glutamate synthase
H6S61_RS11200	COG0067	glutamate synthase
H6S61_RS11200	COG0069	glutamate synthase activity
H6S61_RS11200	COG0070	glutamate synthase
H6S61_RS11210	COG0067	glutamate synthase
H6S61_RS11210	COG0069	glutamate synthase activity
H6S61_RS11210	COG0070	glutamate synthase
H6S61_RS11215	COG1242	4 iron, 4 sulfur cluster binding
H6S61_RS11220	COG2203	Gaf domain
H6S61_RS11220	COG3706	GGDEF domain
H6S61_RS11220	COG4251	negative regulation of phosphorylation
H6S61_RS11220	COG5001	Diguanylate cyclase
H6S61_RS11225	COG0784	Response regulator, receiver
H6S61_RS11225	COG5002	protein histidine kinase activity
H6S61_RS11225	COG2198	Histidine kinase
H6S61_RS11235	COG0745	RESPONSE REGULATOR receiver
H6S61_RS11245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H6S61_RS11260	COG0083	homoserine kinase activity
H6S61_RS11265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H6S61_RS11270	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H6S61_RS11280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H6S61_RS11295	COG1115	amino acid carrier protein
H6S61_RS11300	COG3022	response to hydroperoxide
H6S61_RS11305	COG0513	Belongs to the DEAD box helicase family
H6S61_RS11325	COG4974	Belongs to the 'phage' integrase family
H6S61_RS11330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H6S61_RS11335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H6S61_RS11345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H6S61_RS11365	COG0667	Aldo Keto reductase
H6S61_RS11375	COG3066	DNA modification
H6S61_RS11380	COG0494	nUDIX hydrolase
H6S61_RS11390	COG0730	response to heat
H6S61_RS11410	COG1283	sodium-dependent phosphate transmembrane transporter activity
H6S61_RS11415	COG0583	DNA-binding transcription factor activity
H6S61_RS11420	COG0640	Transcriptional regulator
H6S61_RS11425	COG0268	Binds directly to 16S ribosomal RNA
H6S61_RS11430	COG0728	peptidoglycan biosynthetic process
H6S61_RS11435	COG0196	riboflavin kinase activity
H6S61_RS11440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H6S61_RS11445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H6S61_RS11450	COG1047	Peptidyl-prolyl cis-trans
H6S61_RS11455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H6S61_RS11465	COG3275	phosphorelay sensor kinase activity
H6S61_RS11470	COG1966	Carbon starvation protein
H6S61_RS11485	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H6S61_RS11500	COG1605	Chorismate mutase
H6S61_RS11500	COG0287	Prephenate dehydrogenase
H6S61_RS11505	COG0739	heme binding
H6S61_RS11515	COG0488	(ABC) transporter
H6S61_RS11525	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H6S61_RS11530	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H6S61_RS11535	COG1605	Chorismate mutase
H6S61_RS11535	COG0077	Prephenate dehydratase
H6S61_RS11540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H6S61_RS11545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6S61_RS11560	COG0542	response to heat
H6S61_RS11600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H6S61_RS11605	COG0826	peptidase U32
H6S61_RS11615	COG0745	RESPONSE REGULATOR receiver
H6S61_RS11620	COG5002	protein histidine kinase activity
H6S61_RS11630	COG0248	Ppx GppA phosphatase
H6S61_RS11640	COG0573	inorganic phosphate transmembrane transporter activity
H6S61_RS11650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H6S61_RS11655	COG0704	Plays a role in the regulation of phosphate uptake
H6S61_RS11670	COG0450	alkyl hydroperoxide reductase
H6S61_RS11675	COG0583	DNA-binding transcription factor activity
H6S61_RS11680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H6S61_RS11690	COG0517	IMP dehydrogenase activity
H6S61_RS11700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H6S61_RS11705	COG0343	queuine tRNA-ribosyltransferase activity
H6S61_RS11710	COG1862	Preprotein translocase
H6S61_RS11715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H6S61_RS11720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H6S61_RS11725	COG0483	inositol monophosphate 1-phosphatase activity
H6S61_RS11730	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H6S61_RS11735	COG1959	2 iron, 2 sulfur cluster binding
H6S61_RS11745	COG0822	iron-sulfur transferase activity
H6S61_RS11750	COG0316	Belongs to the HesB IscA family
H6S61_RS11760	COG0443	Heat shock 70 kDa protein
H6S61_RS11765	COG0633	Ferredoxin
H6S61_RS11770	COG2975	iron-sulfur cluster assembly
H6S61_RS11775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H6S61_RS11780	COG0105	UTP biosynthetic process
H6S61_RS11795	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H6S61_RS11800	COG0124	histidyl-tRNA synthetase
H6S61_RS11805	COG2976	Protein conserved in bacteria
H6S61_RS11810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6S61_RS11825	COG2199	diguanylate cyclase activity
H6S61_RS11825	COG2203	Gaf domain
H6S61_RS11835	COG1570	exodeoxyribonuclease VII activity
H6S61_RS11840	COG0517	IMP dehydrogenase activity
H6S61_RS11840	COG0516	GMP reductase activity
H6S61_RS11845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H6S61_RS11845	COG0519	Catalyzes the synthesis of GMP from XMP
H6S61_RS11855	COG1584	GPR1 FUN34 yaaH family protein
H6S61_RS11860	COG1115	amino acid carrier protein
H6S61_RS11870	COG0583	DNA-binding transcription factor activity
H6S61_RS11885	COG0009	L-threonylcarbamoyladenylate synthase
H6S61_RS11985	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H6S61_RS12025	COG0582	viral genome integration into host DNA
H6S61_RS12035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H6S61_RS12040	COG2867	negative regulation of translational initiation
H6S61_RS12045	COG2914	Belongs to the UPF0125 (RnfH) family
H6S61_RS12050	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6S61_RS12055	COG0497	DNA recombination
H6S61_RS12060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H6S61_RS12065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H6S61_RS12095	COG0443	Heat shock 70 kDa protein
H6S61_RS12100	COG0484	heat shock protein binding
H6S61_RS12130	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H6S61_RS12135	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H6S61_RS12140	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H6S61_RS12145	COG0583	DNA-binding transcription factor activity
H6S61_RS12155	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H6S61_RS12185	COG2195	Cleaves the N-terminal amino acid of tripeptides
H6S61_RS12190	COG2252	PERMEase
H6S61_RS12195	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H6S61_RS12200	COG1073	alpha beta
H6S61_RS12210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H6S61_RS12220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H6S61_RS12225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H6S61_RS12225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H6S61_RS12240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H6S61_RS12245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H6S61_RS12250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H6S61_RS12255	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H6S61_RS12265	COG0142	geranyltranstransferase activity
H6S61_RS12270	COG1722	exodeoxyribonuclease VII activity
H6S61_RS12275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H6S61_RS12300	COG0583	DNA-binding transcription factor activity
H6S61_RS12310	COG2363	Small membrane protein
H6S61_RS12325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6S61_RS12330	COG1611	Belongs to the LOG family
H6S61_RS12355	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H6S61_RS12360	COG1464	Belongs to the NlpA lipoprotein family
H6S61_RS12365	COG2011	ABC-type metal ion transport system permease component
H6S61_RS12370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H6S61_RS12375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H6S61_RS12385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_RS12385	COG1263	PTS System
H6S61_RS12390	COG0366	Alpha amylase catalytic
H6S61_RS12420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H6S61_RS12430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H6S61_RS12435	COG0321	lipoyl(octanoyl) transferase activity
H6S61_RS12440	COG2921	Belongs to the UPF0250 family
H6S61_RS12445	COG1686	Belongs to the peptidase S11 family
H6S61_RS12450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H6S61_RS12455	COG0772	Belongs to the SEDS family
H6S61_RS12460	COG0768	penicillin binding
H6S61_RS12465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H6S61_RS12470	COG0799	negative regulation of ribosome biogenesis
H6S61_RS12475	COG1466	dna polymerase III delta subunit
H6S61_RS12480	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H6S61_RS12490	COG2888	peptidyl-tyrosine sulfation
H6S61_RS12500	COG4535	Mg2 and Co2 transporter CorC
H6S61_RS12505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H6S61_RS12510	COG1702	phosphate starvation-inducible protein PhoH
H6S61_RS12515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H6S61_RS12520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H6S61_RS12525	COG3344	reverse transcriptase
H6S61_RS12610	COG0193	aminoacyl-tRNA hydrolase activity
H6S61_RS12615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H6S61_RS12620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H6S61_RS12635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H6S61_RS12640	COG2890	protein-(glutamine-N5) methyltransferase activity
H6S61_RS12650	COG2912	Transglutaminase-like superfamily
H6S61_RS12655	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H6S61_RS12670	COG1187	pseudouridine synthase activity
H6S61_RS12675	COG2840	Smr protein MutS2
H6S61_RS12690	COG3735	TraB family
H6S61_RS12705	COG2608	mercury ion transmembrane transporter activity
H6S61_RS12705	COG2217	Heavy metal translocating P-type atpase
H6S61_RS12765	COG0784	Response regulator, receiver
H6S61_RS12765	COG0835	chemotaxis
H6S61_RS12770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H6S61_RS12775	COG1815	bacterial-type flagellum-dependent cell motility
H6S61_RS12790	COG1749	Flagellar hook protein flgE
H6S61_RS12795	COG4787	bacterial-type flagellum-dependent cell motility
H6S61_RS12810	COG1706	bacterial-type flagellum-dependent cell motility
H6S61_RS12815	COG1705	Flagellar rod assembly protein muramidase FlgJ
H6S61_RS12815	COG3951	Flagellar rod assembly protein muramidase FlgJ
H6S61_RS12825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_RS12830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_RS12835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_RS12840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H6S61_RS12845	COG2190	(PTS) system
H6S61_RS12850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H6S61_RS12855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_RS12860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H6S61_RS12865	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H6S61_RS12895	COG0330	HflC and HflK could
H6S61_RS12900	COG3118	belongs to the thioredoxin family
H6S61_RS12905	COG0300	oxidoreductase activity
H6S61_RS12910	COG1090	epimerase
H6S61_RS12935	COG0622	Phosphoesterase
H6S61_RS12955	COG3710	Transcriptional regulator
H6S61_RS12960	COG0326	Molecular chaperone. Has ATPase activity
H6S61_RS12970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H6S61_RS12980	COG3104	oligopeptide transport
H6S61_RS12990	COG0367	asparagine synthase
H6S61_RS13000	COG4651	solute:proton antiporter activity
H6S61_RS13000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H6S61_RS13005	COG1940	carbohydrate kinase activity
H6S61_RS13005	COG1846	Transcriptional regulator
H6S61_RS13010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H6S61_RS13015	COG2190	(PTS) system
H6S61_RS13015	COG1263	PTS System
H6S61_RS13015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_RS13020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6S61_RS13035	COG0716	FMN binding
H6S61_RS13045	COG0596	Alpha beta hydrolase
H6S61_RS13050	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H6S61_RS13055	COG0033	Phosphoglucomutase
H6S61_RS13060	COG2964	Protein conserved in bacteria
H6S61_RS13065	COG0251	oxidation-reduction process
H6S61_RS13075	COG0446	pyridine nucleotide-disulphide oxidoreductase
H6S61_RS13085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H6S61_RS13095	COG2009	succinate dehydrogenase
H6S61_RS13100	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H6S61_RS13105	COG1053	succinate dehydrogenase
H6S61_RS13115	COG0567	Dehydrogenase, E1 component
H6S61_RS13120	COG0508	dehydrogenase complex catalyzes the overall conversion of
H6S61_RS13135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H6S61_RS13140	COG1121	(ABC) transporter
H6S61_RS13145	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H6S61_RS13155	COG1918	ferrous iron import across plasma membrane
H6S61_RS13180	COG3102	Protein conserved in bacteria
H6S61_RS13185	COG0788	formyltetrahydrofolate deformylase activity
H6S61_RS13195	COG1199	ATP-dependent helicase activity
H6S61_RS13200	COG1214	PFAM Peptidase M22, glycoprotease
H6S61_RS13215	COG0596	Alpha beta hydrolase
H6S61_RS13220	COG0318	PFAM AMP-dependent synthetase and ligase
H6S61_RS13225	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H6S61_RS13230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H6S61_RS13235	COG2894	cell division
H6S61_RS13240	COG0850	regulation of cytokinetic process
H6S61_RS13250	COG2951	lytic endotransglycosylase activity
H6S61_RS13260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H6S61_RS13270	COG0745	RESPONSE REGULATOR receiver
H6S61_RS13275	COG5002	protein histidine kinase activity
H6S61_RS13290	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS13300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H6S61_RS13325	COG2986	histidine ammonia-lyase
H6S61_RS13330	COG1216	Glycosyl transferase, family 2
H6S61_RS13350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H6S61_RS13355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H6S61_RS13415	COG1175	transmembrane transport
H6S61_RS13425	COG3842	ATPase activity
H6S61_RS13430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6S61_RS13435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H6S61_RS13440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H6S61_RS13445	COG2204	response regulator
H6S61_RS13450	COG4191	Histidine kinase
H6S61_RS13455	COG0544	peptidyl-prolyl cis-trans isomerase activity
H6S61_RS13465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H6S61_RS13470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H6S61_RS13475	COG0776	regulation of translation
H6S61_RS13480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H6S61_RS13485	COG1555	photosystem II stabilization
H6S61_RS13495	COG3148	PFAM DTW domain containing protein
H6S61_RS13500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H6S61_RS13505	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H6S61_RS13510	COG0436	Aminotransferase
H6S61_RS13515	COG1169	isochorismate synthase
H6S61_RS13525	COG0596	Alpha beta hydrolase
H6S61_RS13530	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H6S61_RS13540	COG0318	PFAM AMP-dependent synthetase and ligase
H6S61_RS13600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_RS13625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H6S61_RS13630	COG1522	sequence-specific DNA binding
H6S61_RS13640	COG1946	Acyl-CoA thioesterase
H6S61_RS13645	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H6S61_RS13675	COG0330	HflC and HflK could
H6S61_RS13715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H6S61_RS13730	COG3139	Protein of unknown function (DUF1315)
H6S61_RS13735	COG0252	asparaginase activity
H6S61_RS13740	COG0616	signal peptide processing
H6S61_RS13745	COG0446	pyridine nucleotide-disulphide oxidoreductase
H6S61_RS13745	COG1902	pentaerythritol trinitrate reductase activity
H6S61_RS13750	COG0778	Nitroreductase
H6S61_RS13755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H6S61_RS13760	COG0123	including yeast histone deacetylase and acetoin utilization protein
H6S61_RS13765	COG2205	protein histidine kinase activity
H6S61_RS13765	COG0784	Response regulator, receiver
H6S61_RS13775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6S61_RS13780	COG2731	YhcH YjgK YiaL family protein
H6S61_RS13785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H6S61_RS13790	COG0569	domain protein
H6S61_RS13805	COG1396	sequence-specific DNA binding
H6S61_RS13815	COG3083	sulfuric ester hydrolase activity
H6S61_RS13820	COG3082	Protein of unknown function (DUF1414)
H6S61_RS13825	COG3081	Nucleoid-associated protein
H6S61_RS13840	COG1757	Na H antiporter
H6S61_RS13845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H6S61_RS13855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H6S61_RS13860	COG2095	MarC family integral membrane protein
H6S61_RS13865	COG1454	alcohol dehydrogenase
H6S61_RS13865	COG1012	belongs to the aldehyde dehydrogenase family
H6S61_RS13875	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS13890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H6S61_RS13900	COG2056	Na+-H+ antiporter family
H6S61_RS13905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H6S61_RS13910	COG2885	chlorophyll binding
H6S61_RS13920	COG0346	lactoylglutathione lyase activity
H6S61_RS13925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H6S61_RS13930	COG4660	Part of a membrane complex involved in electron transport
H6S61_RS13935	COG4659	FMN binding
H6S61_RS13945	COG4656	Part of a membrane complex involved in electron transport
H6S61_RS13950	COG2878	Part of a membrane complex involved in electron transport
H6S61_RS13955	COG4657	Part of a membrane complex involved in electron transport
H6S61_RS13965	COG0556	nucleotide-excision repair
H6S61_RS13970	COG2204	response regulator
H6S61_RS13975	COG2198	Histidine kinase
H6S61_RS13980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H6S61_RS13990	COG0521	Mo-molybdopterin cofactor biosynthetic process
H6S61_RS13995	COG0315	cyclic pyranopterin monophosphate synthase activity
H6S61_RS14000	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H6S61_RS14005	COG0314	molybdopterin synthase activity
H6S61_RS14015	COG0601	transmembrane transport
H6S61_RS14020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6S61_RS14025	COG0444	Belongs to the ABC transporter superfamily
H6S61_RS14035	COG0435	Glutathione S-transferase
H6S61_RS14045	COG2350	Protein conserved in bacteria
H6S61_RS14065	COG1301	dicarboxylic acid transport
H6S61_RS14075	COG0133	tryptophan synthase activity
H6S61_RS14080	COG0134	indole-3-glycerol-phosphate synthase activity
H6S61_RS14080	COG0135	phosphoribosylanthranilate isomerase activity
H6S61_RS14090	COG0512	Glutamine amidotransferase of anthranilate synthase
H6S61_RS14095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H6S61_RS14105	COG0613	PHP domain protein
H6S61_RS14110	COG0009	L-threonylcarbamoyladenylate synthase
H6S61_RS14130	COG3344	reverse transcriptase
H6S61_RS14140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H6S61_RS14150	COG5001	Diguanylate cyclase
H6S61_RS14155	COG0417	DNA replication proofreading
H6S61_RS14160	COG2197	response regulator
H6S61_RS14165	COG0322	excinuclease ABC activity
H6S61_RS14230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H6S61_RS14235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H6S61_RS14240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H6S61_RS14260	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H6S61_RS14265	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H6S61_RS14270	COG0437	4 iron, 4 sulfur cluster binding
H6S61_RS14275	COG3301	Polysulphide reductase, NrfD
H6S61_RS14280	COG1138	Cytochrome C-type biogenesis protein
H6S61_RS14285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H6S61_RS14290	COG3088	subunit of a heme lyase
H6S61_RS14305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6S61_RS14305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6S61_RS14310	COG0489	protein tyrosine kinase activity
H6S61_RS14315	COG0572	uridine kinase
H6S61_RS14325	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H6S61_RS14330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H6S61_RS14335	COG0659	secondary active sulfate transmembrane transporter activity
H6S61_RS14340	COG1530	ribonuclease E activity
H6S61_RS14350	COG0424	maF-like protein
H6S61_RS14355	COG1399	metal-binding, possibly nucleic acid-binding protein
H6S61_RS14360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H6S61_RS14365	COG0416	fatty acid biosynthetic process
H6S61_RS14370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H6S61_RS14385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H6S61_RS14400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H6S61_RS14405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H6S61_RS14420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_RS14420	COG1263	PTS System
H6S61_RS14435	COG0733	neurotransmitter:sodium symporter activity
H6S61_RS14450	COG4667	esterase of the alpha-beta hydrolase superfamily
H6S61_RS14455	COG0469	pyruvate kinase activity
H6S61_RS14460	COG1940	carbohydrate kinase activity
H6S61_RS14465	COG0835	chemotaxis
H6S61_RS14465	COG0784	Response regulator, receiver
H6S61_RS14470	COG0587	DNA-directed DNA polymerase activity
H6S61_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS14490	COG0616	signal peptide processing
H6S61_RS14500	COG0539	negative regulation of cytoplasmic translation
H6S61_RS14510	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H6S61_RS14515	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H6S61_RS14520	COG0284	orotidine-5'-phosphate decarboxylase activity
H6S61_RS14525	COG4174	ABC transporter (Permease)
H6S61_RS14530	COG4239	(ABC) transporter, permease
H6S61_RS14535	COG4166	transmembrane transport
H6S61_RS14540	COG0444	Belongs to the ABC transporter superfamily
H6S61_RS14545	COG4608	Belongs to the ABC transporter superfamily
H6S61_RS14570	COG0583	DNA-binding transcription factor activity
H6S61_RS14580	COG0686	Belongs to the AlaDH PNT family
H6S61_RS14595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H6S61_RS14600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H6S61_RS14615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H6S61_RS14630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H6S61_RS14640	COG0501	Belongs to the peptidase M48B family
H6S61_RS14650	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS14665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H6S61_RS14685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H6S61_RS14690	COG2915	High frequency lysogenization protein hflD homolog
H6S61_RS14695	COG0482	sulfurtransferase activity
H6S61_RS14705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6S61_RS14710	COG2916	Histone family protein nucleoid-structuring protein H-NS
H6S61_RS14715	COG1757	Na H antiporter
H6S61_RS14720	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H6S61_RS14725	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H6S61_RS14730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H6S61_RS14735	COG0131	Imidazoleglycerol-phosphate dehydratase
H6S61_RS14735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H6S61_RS14740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H6S61_RS14745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H6S61_RS14760	COG3012	SEC-C Motif Domain Protein
H6S61_RS14765	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H6S61_RS14770	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6S61_RS14775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H6S61_RS14785	COG1435	thymidine kinase activity
H6S61_RS14795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H6S61_RS14800	COG0583	DNA-binding transcription factor activity
H6S61_RS14820	COG2116	formate transmembrane transporter activity
H6S61_RS14825	COG0390	transport system, permease component
H6S61_RS14830	COG4459	periplasmic nitrate reductase
H6S61_RS14835	COG3005	denitrification pathway
H6S61_RS14840	COG0243	molybdopterin cofactor binding
H6S61_RS14870	COG1227	inorganic diphosphatase activity
H6S61_RS14885	COG4172	Belongs to the ABC transporter superfamily
H6S61_RS14910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H6S61_RS14915	COG1842	Phage shock protein A
H6S61_RS14925	COG1983	PspC domain protein
H6S61_RS14945	COG2818	Glycosylase
H6S61_RS14950	COG0626	cystathionine gamma-synthase activity
H6S61_RS14960	COG0733	neurotransmitter:sodium symporter activity
H6S61_RS14975	COG0564	pseudouridine synthase activity
H6S61_RS14985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H6S61_RS14990	COG1151	hydroxylamine reductase activity
H6S61_RS14995	COG3604	Transcriptional regulator
H6S61_RS15000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H6S61_RS15005	COG4136	ATPase activity
H6S61_RS15010	COG4135	transport system, permease component
H6S61_RS15015	COG4134	Bacterial extracellular solute-binding protein
H6S61_RS15025	COG3313	Fe-S protein
H6S61_RS15050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H6S61_RS15055	COG2205	protein histidine kinase activity
H6S61_RS15070	COG1061	Type III restriction enzyme res subunit
H6S61_RS15080	COG2814	Major facilitator Superfamily
H6S61_RS15090	COG0702	epimerase
H6S61_RS15110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H6S61_RS15125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H6S61_RS15130	COG3273	potassium ion transport
H6S61_RS15130	COG2985	domain, Protein
H6S61_RS15135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H6S61_RS15140	COG1979	alcohol dehydrogenase
H6S61_RS15145	COG1737	Transcriptional regulator
H6S61_RS15150	COG0076	glutamate decarboxylase activity
H6S61_RS15160	COG2431	L-lysine efflux transmembrane transporter activity
H6S61_RS15170	COG3070	regulator of competence-specific genes
H6S61_RS15185	COG5002	protein histidine kinase activity
H6S61_RS15185	COG5002	protein histidine kinase activity
H6S61_RS15200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H6S61_RS15205	COG4988	ABC transporter
H6S61_RS15210	COG0492	ferredoxin-NADP+ reductase activity
H6S61_RS15220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H6S61_RS15235	COG0471	metal ion transport
H6S61_RS15240	COG2949	membrane
H6S61_RS15245	COG0281	malic enzyme
H6S61_RS15250	COG1643	Atp-dependent helicase
H6S61_RS15265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H6S61_RS15275	COG1346	cytolysis
H6S61_RS15280	COG1380	Effector of murein hydrolase LrgA
H6S61_RS15285	COG2925	Exonuclease
H6S61_RS15300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H6S61_RS15330	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H6S61_RS15360	COG1451	nucleotide metabolic process
H6S61_RS15375	COG3063	Type IV pilus biogenesis stability protein PilW
H6S61_RS15380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H6S61_RS15385	COG0737	Belongs to the 5'-nucleotidase family
H6S61_RS15390	COG2195	Cleaves the N-terminal amino acid of tripeptides
H6S61_RS15400	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H6S61_RS15410	COG0625	glutathione transferase activity
H6S61_RS15450	COG1278	Cold shock
H6S61_RS15460	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H6S61_RS15465	COG0584	glycerophosphoryl diester phosphodiesterase
H6S61_RS15470	COG1349	DNA-binding transcription factor activity
H6S61_RS15475	COG3842	ATPase activity
H6S61_RS15480	COG0395	ABC-type sugar transport system, permease component
H6S61_RS15485	COG1175	transmembrane transport
H6S61_RS15500	COG0730	response to heat
H6S61_RS15510	COG2197	response regulator
H6S61_RS15550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H6S61_RS15560	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H6S61_RS15565	COG0372	Belongs to the citrate synthase family
H6S61_RS15570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H6S61_RS15575	COG2828	Protein conserved in bacteria
H6S61_RS15630	COG0561	phosphatase activity
H6S61_RS15635	COG0602	queuosine metabolic process
H6S61_RS15640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H6S61_RS15645	COG3706	GGDEF domain
H6S61_RS15675	COG4989	oxidoreductase activity
H6S61_RS15685	COG2195	Cleaves the N-terminal amino acid of tripeptides
H6S61_RS15705	COG0840	transmembrane signaling receptor activity
H6S61_RS15710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H6S61_RS15715	COG0545	Peptidyl-prolyl cis-trans isomerase
H6S61_RS15745	COG1278	Cold shock
H6S61_RS15750	COG3036	rescue of stalled ribosome
H6S61_RS15760	COG2203	Gaf domain
H6S61_RS15760	COG2199	diguanylate cyclase activity
H6S61_RS15770	COG1482	cell wall glycoprotein biosynthetic process
H6S61_RS15775	COG2271	Major facilitator Superfamily
H6S61_RS15780	COG3851	Histidine kinase
H6S61_RS15785	COG2197	response regulator
H6S61_RS15800	COG3710	Transcriptional regulator
H6S61_RS15800	COG0457	Tetratricopeptide repeat
H6S61_RS15815	COG2130	NADP-dependent
H6S61_RS15820	COG1309	transcriptional regulator
H6S61_RS15835	COG1278	Cold shock
H6S61_RS15855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H6S61_RS15860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H6S61_RS15865	COG1960	acyl-CoA dehydrogenase activity
H6S61_RS15875	COG0183	Belongs to the thiolase family
H6S61_RS15890	COG1024	Enoyl-CoA hydratase
H6S61_RS15895	COG1024	Enoyl-CoA hydratase
H6S61_RS15905	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS15930	COG2994	toxin metabolic process
H6S61_RS15990	COG0784	Response regulator, receiver
H6S61_RS15990	COG3437	response regulator, receiver
H6S61_RS15995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6S61_RS15995	COG4191	Histidine kinase
H6S61_RS16005	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H6S61_RS16035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H6S61_RS16040	COG3186	Phenylalanine-4-hydroxylase
H6S61_RS16045	COG2154	pterin-4-alpha-carbinolamine dehydratase
H6S61_RS16065	COG3530	Putative quorum-sensing-regulated virulence factor
H6S61_RS16085	COG0515	serine threonine protein kinase
H6S61_RS16085	COG2815	serine threonine protein kinase
H6S61_RS16120	COG0631	protein serine/threonine phosphatase activity
H6S61_RS16225	COG3209	COG3209 Rhs family protein
H6S61_RS16235	COG0501	Belongs to the peptidase M48B family
H6S61_RS16240	COG1704	LemA family
H6S61_RS16245	COG3069	C4-dicarboxylate transmembrane transporter activity
H6S61_RS16255	COG0312	modulator of DNA gyrase
H6S61_RS16260	COG0312	modulator of DNA gyrase
H6S61_RS16265	COG0584	glycerophosphoryl diester phosphodiesterase
H6S61_RS16270	COG2271	Major facilitator Superfamily
H6S61_RS16285	COG0840	transmembrane signaling receptor activity
H6S61_RS16290	COG0840	transmembrane signaling receptor activity
H6S61_RS16295	COG0366	Alpha amylase catalytic
H6S61_RS16305	COG0243	molybdopterin cofactor binding
H6S61_RS16310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H6S61_RS16310	COG1648	precorrin-2 dehydrogenase activity
H6S61_RS16325	COG3707	response regulator
H6S61_RS16330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H6S61_RS16330	COG1116	anion transmembrane transporter activity
H6S61_RS16335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H6S61_RS16340	COG1116	anion transmembrane transporter activity
H6S61_RS16345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H6S61_RS16345	COG2146	nitrite reductase [NAD(P)H] activity
H6S61_RS16360	COG2203	Gaf domain
H6S61_RS16360	COG2199	diguanylate cyclase activity
H6S61_RS16370	COG0523	cobalamin synthesis protein
H6S61_RS16380	COG0513	Belongs to the DEAD box helicase family
H6S61_RS16385	COG0010	Belongs to the arginase family
H6S61_RS16395	COG3706	GGDEF domain
H6S61_RS16395	COG4251	negative regulation of phosphorylation
H6S61_RS16395	COG5001	Diguanylate cyclase
H6S61_RS16395	COG2203	Gaf domain
H6S61_RS16405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H6S61_RS16430	COG0840	transmembrane signaling receptor activity
H6S61_RS16435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H6S61_RS16470	COG0811	peptide transport
H6S61_RS16475	COG0811	peptide transport
H6S61_RS16480	COG0848	biopolymer transport protein
H6S61_RS16495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H6S61_RS16500	COG0840	transmembrane signaling receptor activity
H6S61_RS16515	COG0534	Mate efflux family protein
H6S61_RS16525	COG0477	Major facilitator Superfamily
H6S61_RS16530	COG3118	belongs to the thioredoxin family
H6S61_RS16535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H6S61_RS16590	COG1328	CTP reductase activity
H6S61_RS16595	COG0602	queuosine metabolic process
H6S61_RS16605	COG4067	protein conserved in archaea
H6S61_RS16605	COG0189	ligase activity
H6S61_RS16625	COG0725	ABC transporter, periplasmic molybdate-binding protein
H6S61_RS16630	COG4149	molybdate abc transporter
H6S61_RS16640	COG0697	spore germination
H6S61_RS16645	COG1846	Transcriptional regulator
H6S61_RS16655	COG2199	diguanylate cyclase activity
H6S61_RS16665	COG3706	GGDEF domain
H6S61_RS16680	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H6S61_RS16685	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H6S61_RS16695	COG0745	RESPONSE REGULATOR receiver
H6S61_RS16710	COG3140	Belongs to the UPF0181 family
H6S61_RS16715	COG3344	reverse transcriptase
H6S61_RS16790	COG0023	Translation Initiation Factor
H6S61_RS16800	COG1181	Belongs to the D-alanine--D-alanine ligase family
H6S61_RS16810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H6S61_RS16810	COG0045	succinate-CoA ligase (ADP-forming) activity
H6S61_RS16810	COG1042	CoA-binding domain protein
H6S61_RS16815	COG0583	DNA-binding transcription factor activity
H6S61_RS16825	COG5002	protein histidine kinase activity
H6S61_RS16825	COG3447	MASE1 domain protein
H6S61_RS16825	COG5001	Diguanylate cyclase
H6S61_RS16835	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H6S61_RS16840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H6S61_RS16845	COG1984	allophanate hydrolase subunit 2
H6S61_RS16850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H6S61_RS16850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6S61_RS16855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H6S61_RS16860	COG4181	ATPase activity
H6S61_RS16870	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H6S61_RS16875	COG5001	Diguanylate cyclase
H6S61_RS16875	COG1716	ATPase activity
H6S61_RS16890	COG0484	heat shock protein binding
H6S61_RS16910	COG0583	DNA-binding transcription factor activity
H6S61_RS16915	COG0366	Alpha amylase catalytic
H6S61_RS16925	COG4533	DNA binding
H6S61_RS16935	COG2050	protein possibly involved in aromatic compounds catabolism
H6S61_RS16950	COG2067	long-chain fatty acid transport protein
H6S61_RS16955	COG2267	carboxylic ester hydrolase activity
H6S61_RS16985	COG0861	Integral membrane protein TerC family
H6S61_RS16990	COG0737	Belongs to the 5'-nucleotidase family
H6S61_RS16995	COG3593	DNA synthesis involved in DNA repair
H6S61_RS17005	COG0583	DNA-binding transcription factor activity
H6S61_RS17010	COG2116	formate transmembrane transporter activity
H6S61_RS17015	COG2353	YceI-like domain
H6S61_RS17020	COG3038	cytochrome b561
H6S61_RS17035	COG0513	Belongs to the DEAD box helicase family
H6S61_RS17050	COG0546	phosphoglycolate phosphatase activity
H6S61_RS17055	COG0784	Response regulator, receiver
H6S61_RS17055	COG3437	response regulator, receiver
H6S61_RS17070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6S61_RS17075	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H6S61_RS17080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H6S61_RS17090	COG2207	Transcriptional regulator
H6S61_RS17095	COG1979	alcohol dehydrogenase
H6S61_RS17105	COG4191	Histidine kinase
H6S61_RS17115	COG2271	Major facilitator Superfamily
H6S61_RS17120	COG0469	pyruvate kinase activity
H6S61_RS17145	COG1609	Transcriptional regulator
H6S61_RS17150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_RS17150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_RS17155	COG1105	Belongs to the carbohydrate kinase PfkB family
H6S61_RS17160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS17160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS17160	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H6S61_RS17205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H6S61_RS17210	COG0509	glycine decarboxylation via glycine cleavage system
H6S61_RS17215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H6S61_RS17215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H6S61_RS17230	COG1132	(ABC) transporter
H6S61_RS17245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H6S61_RS17270	COG2814	Major facilitator Superfamily
H6S61_RS17300	COG0641	radical SAM
H6S61_RS17310	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
H6S61_RS17345	COG0714	Associated with various cellular activities
H6S61_RS17365	COG3119	arylsulfatase activity
H6S61_RS17370	COG0604	alcohol dehydrogenase
H6S61_RS17375	COG1902	pentaerythritol trinitrate reductase activity
H6S61_RS17380	COG1902	pentaerythritol trinitrate reductase activity
H6S61_RS17385	COG0583	DNA-binding transcription factor activity
H6S61_RS17390	COG2814	Major facilitator Superfamily
H6S61_RS17400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H6S61_RS17410	COG0513	Belongs to the DEAD box helicase family
H6S61_RS17415	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H6S61_RS17430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H6S61_RS17455	COG1716	ATPase activity
H6S61_RS17455	COG5001	Diguanylate cyclase
H6S61_RS17465	COG0513	Belongs to the DEAD box helicase family
H6S61_RS17480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H6S61_RS17505	COG1879	ABC-type sugar transport system periplasmic component
H6S61_RS17510	COG1803	Methylglyoxal synthase
H6S61_RS17515	COG0210	DNA helicase
H6S61_RS17520	COG1289	transmembrane transporter activity
H6S61_RS17550	COG0789	Transcriptional regulator
H6S61_RS17555	COG4604	ABC transporter, ATP-binding protein
H6S61_RS17560	COG4605	iron ion homeostasis
H6S61_RS17565	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H6S61_RS17590	COG0110	maltose O-acetyltransferase activity
H6S61_RS17600	COG3290	protein histidine kinase activity
H6S61_RS17685	COG4964	Belongs to the GSP D family
H6S61_RS17705	COG0583	DNA-binding transcription factor activity
H6S61_RS17720	COG0419	ATPase involved in DNA repair
H6S61_RS17725	COG0420	3'-5' exonuclease activity
H6S61_RS17735	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H6S61_RS17740	COG0456	acetyltransferase
H6S61_RS17750	COG0784	Response regulator, receiver
H6S61_RS17750	COG0835	chemotaxis
H6S61_RS17755	COG1609	Transcriptional regulator
H6S61_RS17760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6S61_RS17765	COG1879	ABC-type sugar transport system periplasmic component
H6S61_RS17770	COG1172	Belongs to the binding-protein-dependent transport system permease family
H6S61_RS17775	COG1129	ABC transporter
H6S61_RS17780	COG1869	D-ribose catabolic process
H6S61_RS17795	COG2315	Protein conserved in bacteria
H6S61_RS17800	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H6S61_RS17815	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H6S61_RS17830	COG1288	antiporter activity
H6S61_RS17840	COG0671	phosphoesterase, PA-phosphatase related
H6S61_RS17855	COG2962	Rard protein
H6S61_RS17880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H6S61_RS17885	COG0814	amino acid
H6S61_RS17910	COG3174	membrane
H6S61_RS17915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_RS17945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H6S61_RS17950	COG0583	DNA-binding transcription factor activity
H6S61_RS17960	COG0443	Heat shock 70 kDa protein
H6S61_RS17965	COG1454	alcohol dehydrogenase
H6S61_RS17975	COG2133	pyrroloquinoline quinone binding
H6S61_RS17980	COG1619	proteins homologs of microcin C7 resistance protein MccF
H6S61_RS17995	COG0247	lactate metabolic process
H6S61_RS18000	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H6S61_RS18025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H6S61_RS18040	COG3059	membrane
H6S61_RS18045	COG4175	Glycine betaine
H6S61_RS18065	COG1309	transcriptional regulator
H6S61_RS18085	COG1686	Belongs to the peptidase S11 family
H6S61_RS18105	COG1760	l-serine dehydratase
H6S61_RS18110	COG3104	oligopeptide transport
H6S61_RS18120	COG0583	DNA-binding transcription factor activity
H6S61_RS18125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H6S61_RS18145	COG3842	ATPase activity
H6S61_RS18150	COG1840	ABC-type Fe3 transport system, periplasmic component
H6S61_RS18155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H6S61_RS18160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H6S61_RS18170	COG2207	Transcriptional regulator
H6S61_RS18170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H6S61_RS18175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6S61_RS18200	COG1011	Hydrolase
H6S61_RS18225	COG1765	OsmC-like protein
H6S61_RS18230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6S61_RS18230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6S61_RS18235	COG3706	GGDEF domain
H6S61_RS18250	COG0840	transmembrane signaling receptor activity
H6S61_RS18270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H6S61_RS18295	COG2084	Dehydrogenase
H6S61_RS18310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H6S61_RS18315	COG0739	heme binding
H6S61_RS18335	COG3314	Sporulation integral membrane protein YlbJ
H6S61_RS18350	COG0840	transmembrane signaling receptor activity
H6S61_RS18360	COG0366	Alpha amylase catalytic
H6S61_RS18365	COG0589	response to stress
H6S61_RS18370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H6S61_RS18375	COG0835	chemotaxis
H6S61_RS18375	COG0784	Response regulator, receiver
H6S61_RS18385	COG0748	coenzyme F420 binding
H6S61_RS18390	COG3721	Heme iron utilization protein
H6S61_RS18400	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H6S61_RS18405	COG0811	peptide transport
H6S61_RS18410	COG0848	biopolymer transport protein
H6S61_RS18420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H6S61_RS18425	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H6S61_RS18470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H6S61_RS18475	COG3217	Mosc domain protein beta barrel domain protein
H6S61_RS18475	COG0633	Ferredoxin
H6S61_RS18475	COG3217	Mosc domain protein beta barrel domain protein
H6S61_RS18475	COG0633	Ferredoxin
H6S61_RS18480	COG0418	dihydroorotase activity
H6S61_RS18490	COG2354	Protein conserved in bacteria
H6S61_RS18520	COG3833	ABC-type maltose transport systems, permease component
H6S61_RS18525	COG1175	transmembrane transport
H6S61_RS18535	COG3842	ATPase activity
H6S61_RS18540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H6S61_RS18550	COG1596	polysaccharide export
H6S61_RS18555	COG3206	protein involved in exopolysaccharide biosynthesis
H6S61_RS18555	COG0489	protein tyrosine kinase activity
H6S61_RS18620	COG0714	Associated with various cellular activities
H6S61_RS18640	COG2304	oxidoreductase activity
H6S61_RS18655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H6S61_RS18660	COG0581	inorganic phosphate transmembrane transporter activity
H6S61_RS18665	COG0573	inorganic phosphate transmembrane transporter activity
H6S61_RS18700	COG0513	Belongs to the DEAD box helicase family
H6S61_RS18725	COG1376	ErfK ybiS ycfS ynhG family protein
H6S61_RS18725	COG1388	LysM domain
H6S61_RS18730	COG0415	Belongs to the DNA photolyase family
H6S61_RS18735	COG0789	Transcriptional regulator
H6S61_RS18740	COG3272	Protein of unknown function (DUF1722)
H6S61_RS18745	COG0813	purine-nucleoside phosphorylase activity
H6S61_RS18770	COG1566	PFAM secretion protein HlyD family protein
H6S61_RS18775	COG4720	Psort location CytoplasmicMembrane, score
H6S61_RS18780	COG1122	ATPase activity
H6S61_RS18795	COG4946	Tricorn protease homolog
H6S61_RS18795	COG0793	Belongs to the peptidase S41A family
H6S61_RS18800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H6S61_RS18825	COG0668	transmembrane transport
H6S61_RS18845	COG1538	Outer membrane efflux protein
H6S61_RS18855	COG2274	protein secretion by the type I secretion system
H6S61_RS18865	COG3111	PFAM Bacterial OB fold (BOF) protein
H6S61_RS18880	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H6S61_RS18915	COG3040	lipid binding
H6S61_RS18975	COG3240	lipase activity
H6S61_RS18990	COG2211	Major facilitator Superfamily
H6S61_RS19000	COG0346	lactoylglutathione lyase activity
H6S61_RS19015	COG0753	catalase activity
H6S61_RS19035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H6S61_RS19045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H6S61_RS19060	COG0393	Putative heavy-metal-binding
H6S61_RS19080	COG4771	TonB-dependent receptor
H6S61_RS19085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H6S61_RS19090	COG0039	L-malate dehydrogenase activity
H6S61_RS19105	COG2814	Major facilitator Superfamily
H6S61_RS19175	COG0351	phosphomethylpyrimidine kinase
H6S61_RS19180	COG0671	phosphoesterase, PA-phosphatase related
H6S61_RS19195	COG0561	phosphatase activity
H6S61_RS19205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H6S61_RS19210	COG0076	glutamate decarboxylase activity
H6S61_RS19215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H6S61_RS19240	COG4221	oxidoreductase activity
H6S61_RS19255	COG0745	RESPONSE REGULATOR receiver
H6S61_RS19260	COG2205	protein histidine kinase activity
H6S61_RS19265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H6S61_RS19270	COG2194	sulfuric ester hydrolase activity
H6S61_RS19275	COG1368	sulfuric ester hydrolase activity
H6S61_RS19290	COG2356	endonuclease I
H6S61_RS19305	COG3706	GGDEF domain
H6S61_RS19315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H6S61_RS19350	COG2175	clavaminate synthase activity
H6S61_RS19355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H6S61_RS19400	COG1301	dicarboxylic acid transport
H6S61_RS19410	COG0137	argininosuccinate synthase activity
H6S61_RS19425	COG0583	DNA-binding transcription factor activity
H6S61_RS19440	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H6S61_RS19475	COG0583	DNA-binding transcription factor activity
H6S61_RS19480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H6S61_RS19485	COG1482	cell wall glycoprotein biosynthetic process
H6S61_RS19490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H6S61_RS19495	COG1263	PTS System
H6S61_RS19495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_RS19500	COG1609	Transcriptional regulator
H6S61_RS19510	COG3383	formate dehydrogenase (NAD+) activity
H6S61_RS19525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS19525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS19525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_RS19530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS19545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS19550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS19560	COG2207	Transcriptional regulator
H6S61_RS19565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_RS19565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS19565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS19570	COG1482	cell wall glycoprotein biosynthetic process
H6S61_RS19595	COG1482	cell wall glycoprotein biosynthetic process
H6S61_RS19600	COG1929	Belongs to the glycerate kinase type-1 family
H6S61_RS19605	COG0383	alpha-mannosidase activity
H6S61_RS19610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS19610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H6S61_RS19610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_RS19615	COG2188	Transcriptional regulator
H6S61_RS19620	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H6S61_RS19625	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H6S61_RS19635	COG2375	cellular response to nickel ion
H6S61_RS19645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H6S61_RS19655	COG2211	Major facilitator Superfamily
H6S61_RS19675	COG1129	ABC transporter
H6S61_RS19685	COG1609	Transcriptional regulator
H6S61_RS19700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_RS19710	COG0564	pseudouridine synthase activity
H6S61_RS19740	COG1566	PFAM secretion protein HlyD family protein
H6S61_RS19750	COG0534	Mate efflux family protein
H6S61_RS19755	COG1472	Belongs to the glycosyl hydrolase 3 family
H6S61_RS19765	COG4580	involved in the transport of maltose and maltodextrins
H6S61_RS19780	COG1609	Transcriptional regulator
H6S61_RS19790	COG4608	Belongs to the ABC transporter superfamily
H6S61_RS19795	COG0444	Belongs to the ABC transporter superfamily
H6S61_RS19800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6S61_RS19810	COG0747	negative chemotaxis
H6S61_RS19820	COG1609	Transcriptional regulator
H6S61_RS19830	COG2723	6-phospho-beta-galactosidase activity
H6S61_RS19835	COG0395	ABC-type sugar transport system, permease component
H6S61_RS19850	COG1609	Transcriptional regulator
H6S61_RS19860	COG2199	diguanylate cyclase activity
H6S61_RS19870	COG0642	Histidine kinase
H6S61_RS19880	COG0583	DNA-binding transcription factor activity
H6S61_RS19890	COG0612	Peptidase, M16
H6S61_RS19895	COG1283	sodium-dependent phosphate transmembrane transporter activity
H6S61_RS19905	COG0625	glutathione transferase activity
H6S61_RS19910	COG1012	belongs to the aldehyde dehydrogenase family
H6S61_RS19960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H6S61_RS19965	COG0840	transmembrane signaling receptor activity
H6S61_RS19970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H6S61_RS19975	COG1640	4-alpha-glucanotransferase
H6S61_RS19980	COG0058	SHG alpha-glucan phosphorylase activity
H6S61_RS19985	COG2909	trisaccharide binding
H6S61_RS20010	COG3842	ATPase activity
H6S61_RS20020	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H6S61_RS20030	COG2182	Extracellular solute-binding protein
H6S61_RS20035	COG1175	transmembrane transport
H6S61_RS20040	COG3833	ABC-type maltose transport systems, permease component
H6S61_RS20070	COG1999	signal sequence binding
H6S61_RS20075	COG2847	Copper chaperone PCu(A)C
H6S61_RS20080	COG1162	GTPase activity
H6S61_RS20085	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H6S61_RS20095	COG0531	amino acid
H6S61_RS20100	COG1982	Orn Lys Arg decarboxylase major
H6S61_RS20150	COG3706	GGDEF domain
H6S61_RS20155	COG5001	Diguanylate cyclase
H6S61_RS20165	COG1741	Belongs to the pirin family
H6S61_RS20170	COG3123	guanosine phosphorylase activity
H6S61_RS20190	COG1309	transcriptional regulator
H6S61_RS20210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H6S61_RS20215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H6S61_RS20220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H6S61_RS20260	COG0363	glucosamine-6-phosphate deaminase activity
H6S61_RS20265	COG3344	reverse transcriptase
H6S61_RS20275	COG0786	glutamate:sodium symporter activity
H6S61_RS20280	COG0786	glutamate:sodium symporter activity
H6S61_RS20300	COG3275	phosphorelay sensor kinase activity
H6S61_RS20320	COG1136	(ABC) transporter
H6S61_RS20335	COG0217	transcriptional regulatory protein
H6S61_RS20355	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H6S61_RS20355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H6S61_RS20365	COG0444	Belongs to the ABC transporter superfamily
H6S61_RS20370	COG4608	Belongs to the ABC transporter superfamily
H6S61_RS20395	COG1444	tRNA N-acetyltransferase activity
H6S61_RS20405	COG0745	RESPONSE REGULATOR receiver
H6S61_RS20420	COG0835	chemotaxis
H6S61_RS20425	COG0840	transmembrane signaling receptor activity
H6S61_RS20430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H6S61_RS20435	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H6S61_RS20440	COG2201	protein-glutamate methylesterase activity
H6S61_RS20445	COG0840	transmembrane signaling receptor activity
H6S61_RS20490	COG0406	alpha-ribazole phosphatase activity
H6S61_RS20510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H6S61_RS20515	COG1737	Transcriptional regulator
H6S61_RS20520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H6S61_RS20520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H6S61_RS20530	COG0110	maltose O-acetyltransferase activity
H6S61_RS20535	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H6S61_RS20540	COG0459	protein refolding
H6S61_RS20555	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H6S61_RS20560	COG3069	C4-dicarboxylate transmembrane transporter activity
H6S61_RS20590	COG2204	response regulator
H6S61_RS20600	COG0259	pyridoxamine-phosphate oxidase activity
H6S61_RS20625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H6S61_RS20650	COG5492	domain, Protein
H6S61_RS20655	COG3119	arylsulfatase activity
H6S61_RS20660	COG3119	arylsulfatase activity
H6S61_RS20665	COG0641	radical SAM
H6S61_RS20670	COG3119	arylsulfatase activity
H6S61_RS20680	COG0747	negative chemotaxis
H6S61_RS20685	COG0601	transmembrane transport
H6S61_RS20690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H6S61_RS20720	COG0659	secondary active sulfate transmembrane transporter activity
H6S61_RS20725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H6S61_RS20735	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS20745	COG5426	von Willebrand factor, type A
H6S61_RS20750	COG5492	domain, Protein
H6S61_RS20755	COG1132	(ABC) transporter
H6S61_RS20770	COG3623	hexulose-6-phosphate isomerase
H6S61_RS20775	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H6S61_RS20780	COG0561	phosphatase activity
H6S61_RS20810	COG1902	pentaerythritol trinitrate reductase activity
H6S61_RS20820	COG2814	Major facilitator Superfamily
H6S61_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS20840	COG0800	Aldolase
H6S61_RS20845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6S61_RS20850	COG1904	glucuronate isomerase
H6S61_RS20855	COG0246	Mannitol dehydrogenase
H6S61_RS20865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H6S61_RS20875	COG2186	Transcriptional regulator
H6S61_RS20885	COG0513	Belongs to the DEAD box helicase family
H6S61_RS20905	COG4115	mRNA cleavage
H6S61_RS20910	COG2258	MOSC domain
H6S61_RS20940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H6S61_RS20955	COG0840	transmembrane signaling receptor activity
H6S61_RS20975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6S61_RS20980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H6S61_RS21030	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H6S61_RS21045	COG1349	DNA-binding transcription factor activity
H6S61_RS21050	COG1349	DNA-binding transcription factor activity
H6S61_RS21060	COG2222	sugar isomerase
H6S61_RS21065	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_RS21075	COG3716	PTS system mannose fructose sorbose family IID component
H6S61_RS21080	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_RS21110	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H6S61_RS21115	COG1120	ATPase activity
H6S61_RS21145	COG0577	efflux transmembrane transporter activity
H6S61_RS21145	COG1136	(ABC) transporter
H6S61_RS21150	COG1136	(ABC) transporter
H6S61_RS21150	COG0577	efflux transmembrane transporter activity
H6S61_RS21155	COG2176	DNA-directed DNA polymerase activity
H6S61_RS21215	COG2205	protein histidine kinase activity
H6S61_RS21230	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H6S61_RS21260	COG0579	oxidoreductase
H6S61_RS21270	COG3437	response regulator, receiver
H6S61_RS21290	COG1357	PFAM Pentapeptide repeats (8 copies)
H6S61_RS21300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H6S61_RS21335	COG0513	Belongs to the DEAD box helicase family
H6S61_RS21355	COG0583	DNA-binding transcription factor activity
H6S61_RS21365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H6S61_RS21395	COG2814	Major facilitator Superfamily
H6S61_RS21400	COG2207	Transcriptional regulator
H6S61_RS21415	COG1858	cytochrome C peroxidase
H6S61_RS21440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H6S61_RS21445	COG0454	-acetyltransferase
H6S61_RS21460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H6S61_RS21460	COG1263	PTS System
H6S61_RS21475	COG3046	protein related to deoxyribodipyrimidine photolyase
H6S61_RS21480	COG2207	Transcriptional regulator
H6S61_RS21485	COG1881	PFAM PEBP family protein
H6S61_RS21490	COG0494	nUDIX hydrolase
H6S61_RS21520	COG0668	transmembrane transport
H6S61_RS21560	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS21570	COG1917	Cupin 2, conserved barrel domain protein
H6S61_RS21585	COG2207	Transcriptional regulator
H6S61_RS21590	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS21595	COG0697	spore germination
H6S61_RS21600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H6S61_RS21605	COG0800	Aldolase
H6S61_RS21610	COG0366	Alpha amylase catalytic
H6S61_RS21620	COG3366	ferrous iron transmembrane transporter activity
H6S61_RS21625	COG0700	Nucleoside recognition
H6S61_RS21630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H6S61_RS21680	COG2194	sulfuric ester hydrolase activity
H6S61_RS21685	COG0583	DNA-binding transcription factor activity
H6S61_RS21695	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H6S61_RS21720	COG0673	inositol 2-dehydrogenase activity
H6S61_RS21725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H6S61_RS21730	COG2197	response regulator
H6S61_RS21735	COG0384	phenazine biosynthesis protein PhzF
H6S61_RS21745	COG0625	glutathione transferase activity
H6S61_RS21750	COG1879	ABC-type sugar transport system periplasmic component
H6S61_RS21760	COG3284	Transcriptional regulator
H6S61_RS21765	COG1012	belongs to the aldehyde dehydrogenase family
H6S61_RS21775	COG1253	flavin adenine dinucleotide binding
H6S61_RS21785	COG0242	peptide deformylase activity
H6S61_RS21800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H6S61_RS21805	COG1609	Transcriptional regulator
H6S61_RS21820	COG0488	(ABC) transporter
H6S61_RS21825	COG0814	amino acid
H6S61_RS21830	COG3033	Beta-eliminating lyase
H6S61_RS21845	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6S61_RS21870	COG0189	ligase activity
H6S61_RS21870	COG4067	protein conserved in archaea
H6S61_RS21875	COG0189	ligase activity
H6S61_RS21885	COG1629	transport
H6S61_RS21885	COG4774	siderophore transport
H6S61_RS21890	COG4607	ABC-type enterochelin transport system periplasmic component
H6S61_RS21900	COG1021	2,3-dihydroxybenzoate-AMP ligase
H6S61_RS21920	COG1021	2,3-dihydroxybenzoate-AMP ligase
H6S61_RS21925	COG1169	isochorismate synthase
H6S61_RS21930	COG1028	Short-chain dehydrogenase reductase Sdr
H6S61_RS21935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H6S61_RS21950	COG2977	Belongs to the P-Pant transferase superfamily
H6S61_RS21965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6S61_RS21970	COG0840	transmembrane signaling receptor activity
H6S61_RS21980	COG2755	lipolytic protein G-D-S-L family
H6S61_RS21985	COG5001	Diguanylate cyclase
H6S61_RS21985	COG5002	protein histidine kinase activity
H6S61_RS22000	COG4160	amino acid transport
H6S61_RS22005	COG4215	(ABC) transporter
H6S61_RS22010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6S61_RS22015	COG1126	abc transporter atp-binding protein
H6S61_RS22020	COG3015	lipoprotein NlpE involved in copper resistance
H6S61_RS22035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H6S61_RS22075	COG2814	Major facilitator Superfamily
H6S61_RS22100	COG1139	Iron-sulfur cluster binding protein
H6S61_RS22110	COG1620	l-lactate permease
H6S61_RS22115	COG0583	DNA-binding transcription factor activity
H6S61_RS22120	COG1505	serine-type exopeptidase activity
H6S61_RS22125	COG4172	Belongs to the ABC transporter superfamily
H6S61_RS22135	COG1067	ATP-dependent peptidase activity
H6S61_RS22140	COG0402	S-adenosylhomocysteine deaminase activity
H6S61_RS22145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H6S61_RS22155	COG2239	Acts as a magnesium transporter
H6S61_RS22180	COG0745	RESPONSE REGULATOR receiver
H6S61_RS22185	COG2205	protein histidine kinase activity
H6S61_RS22200	COG0121	glutamine amidotransferase
H6S61_RS22205	COG0531	amino acid
H6S61_RS22210	COG1522	sequence-specific DNA binding
H6S61_RS22230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H6S61_RS22235	COG0583	DNA-binding transcription factor activity
H6S61_RS22260	COG2205	protein histidine kinase activity
H6S61_RS22260	COG5002	protein histidine kinase activity
H6S61_RS22260	COG0784	Response regulator, receiver
H6S61_RS22270	COG2926	Belongs to the UPF0265 family
H6S61_RS22280	COG3132	Protein of unknown function, DUF480
H6S61_RS22285	COG2827	Endonuclease containing a URI domain
H6S61_RS22335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H6S61_RS22340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H6S61_RS22350	COG0183	Belongs to the thiolase family
H6S61_RS22370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H6S61_RS22375	COG1940	carbohydrate kinase activity
H6S61_RS22380	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H6S61_RS22385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H6S61_RS22390	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H6S61_RS22395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H6S61_RS22400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6S61_RS22405	COG1737	Transcriptional regulator
H6S61_RS22410	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
H6S61_RS22415	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
H6S61_RS22425	COG3005	denitrification pathway
H6S61_RS22435	COG0243	molybdopterin cofactor binding
H6S61_RS22445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H6S61_RS22450	COG3850	Histidine kinase
H6S61_RS22455	COG2197	response regulator
H6S61_RS22475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H6S61_RS22475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H6S61_RS22485	COG0516	GMP reductase activity
H6S61_RS22495	COG2204	response regulator
H6S61_RS22505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H6S61_RS22510	COG0732	type I restriction modification DNA specificity domain
H6S61_RS22530	COG0714	Associated with various cellular activities
H6S61_RS22535	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H6S61_RS22555	COG1538	Outer membrane efflux protein
H6S61_RS22560	COG1566	PFAM secretion protein HlyD family protein
H6S61_RS22605	COG0183	Belongs to the thiolase family
H6S61_RS22615	COG0427	acetyl-CoA hydrolase
H6S61_RS22635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H6S61_RS22655	COG3568	Endonuclease Exonuclease Phosphatase
H6S61_RS22680	COG0513	Belongs to the DEAD box helicase family
H6S61_RS22695	COG1846	Transcriptional regulator
H6S61_RS22720	COG0842	Transport permease protein
H6S61_RS22725	COG1131	(ABC) transporter
H6S61_RS22735	COG1737	Transcriptional regulator
H6S61_RS22735	COG0837	glucose binding
H6S61_RS22745	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H6S61_RS22755	COG4145	pantothenate transmembrane transporter activity
H6S61_RS22770	COG0251	oxidation-reduction process
H6S61_RS22775	COG2203	Gaf domain
H6S61_RS22775	COG3706	GGDEF domain
H6S61_RS22775	COG4251	negative regulation of phosphorylation
H6S61_RS22775	COG5001	Diguanylate cyclase
H6S61_RS22780	COG0583	DNA-binding transcription factor activity
H6S61_RS22785	COG2814	Major facilitator Superfamily
H6S61_RS22800	COG0697	spore germination
H6S61_RS22815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H6S61_RS22825	COG1764	response to oxidative stress
H6S61_RS22830	COG1846	Transcriptional regulator
H6S61_RS22855	COG1280	lysine exporter protein (LysE YggA)
H6S61_RS22865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H6S61_RS22870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H6S61_RS22875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H6S61_RS22880	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H6S61_RS22905	COG1612	heme a metabolic process
H6S61_RS22910	COG0109	protoheme IX farnesyltransferase activity
H6S61_RS22920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H6S61_RS22925	COG0840	transmembrane signaling receptor activity
H6S61_RS22945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H6S61_RS22965	COG2897	thiosulfate sulfurtransferase activity
H6S61_RS22975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H6S61_RS22980	COG0303	'Molybdopterin
H6S61_RS22985	COG0302	gtp cyclohydrolase
H6S61_RS22995	COG0038	chloride channel
H6S61_RS23000	COG3344	reverse transcriptase