locus-tag	class	description
VV93_RS00010	COG0592	DNA-directed DNA polymerase activity
VV93_RS00020	COG0187	DNA topoisomerase II activity
VV93_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
VV93_RS00035	COG3977	Valine--pyruvate aminotransferase
VV93_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
VV93_RS00055	COG2119	membrane
VV93_RS00065	COG0425	Belongs to the sulfur carrier protein TusA family
VV93_RS00080	COG0604	alcohol dehydrogenase
VV93_RS00085	COG0183	Belongs to the thiolase family
VV93_RS00095	COG1739	Uncharacterized protein family UPF0029
VV93_RS00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV93_RS00140	COG3335	DDE superfamily endonuclease
VV93_RS00150	COG3335	DDE superfamily endonuclease
VV93_RS00175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VV93_RS00180	COG2960	long-chain fatty acid transporting porin activity
VV93_RS00185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV93_RS00190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV93_RS00195	COG1309	transcriptional regulator
VV93_RS00235	COG4172	Belongs to the ABC transporter superfamily
VV93_RS00240	COG4166	transmembrane transport
VV93_RS00245	COG0601	transmembrane transport
VV93_RS00250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV93_RS00285	COG0515	serine threonine protein kinase
VV93_RS00285	COG2815	serine threonine protein kinase
VV93_RS00295	COG0745	RESPONSE REGULATOR receiver
VV93_RS00300	COG1609	Transcriptional regulator
VV93_RS00305	COG0129	dihydroxy-acid dehydratase activity
VV93_RS00310	COG3265	gluconokinase activity
VV93_RS00315	COG2610	gluconate transmembrane transporter activity
VV93_RS00320	COG0800	Aldolase
VV93_RS00340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV93_RS00345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VV93_RS00355	COG1522	sequence-specific DNA binding
VV93_RS00360	COG5002	protein histidine kinase activity
VV93_RS00360	COG5001	Diguanylate cyclase
VV93_RS00380	COG0589	response to stress
VV93_RS00385	COG1528	Iron-storage protein
VV93_RS00395	COG2081	HI0933 family
VV93_RS00405	COG2959	enzyme of heme biosynthesis
VV93_RS00415	COG0181	hydroxymethylbilane synthase activity
VV93_RS00420	COG3072	Adenylate cyclase
VV93_RS00425	COG1965	Belongs to the frataxin family
VV93_RS00435	COG0019	diaminopimelate decarboxylase activity
VV93_RS00440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VV93_RS00450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VV93_RS00455	COG1011	Hydrolase
VV93_RS00460	COG2199	diguanylate cyclase activity
VV93_RS00460	COG2200	EAL domain
VV93_RS00460	COG3287	FIST C domain
VV93_RS00465	COG3148	PFAM DTW domain containing protein
VV93_RS00480	COG0561	phosphatase activity
VV93_RS00485	COG2267	carboxylic ester hydrolase activity
VV93_RS00490	COG1280	lysine exporter protein (LysE YggA)
VV93_RS00495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VV93_RS00500	COG0640	Transcriptional regulator
VV93_RS00505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VV93_RS00545	COG2095	MarC family integral membrane protein
VV93_RS00555	COG0742	ribosomal rna small subunit methyltransferase
VV93_RS00560	COG0552	protein localization to endoplasmic reticulum
VV93_RS00565	COG2884	Cell division ATP-binding protein ftsE
VV93_RS00570	COG2177	Part of the ABC transporter FtsEX involved in
VV93_RS00580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV93_RS00585	COG0705	Rhomboid family
VV93_RS00590	COG1580	Controls the rotational direction of flagella during chemotaxis
VV93_RS00605	COG2937	Belongs to the GPAT DAPAT family
VV93_RS00610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VV93_RS00620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV93_RS00665	COG0789	Transcriptional regulator
VV93_RS00685	COG1566	PFAM secretion protein HlyD family protein
VV93_RS00705	COG2205	protein histidine kinase activity
VV93_RS00705	COG0784	Response regulator, receiver
VV93_RS00765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV93_RS00780	COG0346	lactoylglutathione lyase activity
VV93_RS00790	COG0371	Dehydrogenase
VV93_RS00795	COG4932	domain protein
VV93_RS00795	COG5492	domain, Protein
VV93_RS00815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VV93_RS00830	COG4206	TonB-dependent receptor
VV93_RS00875	COG3335	DDE superfamily endonuclease
VV93_RS00895	COG1322	Protein conserved in bacteria
VV93_RS00900	COG2226	methyltransferase
VV93_RS00905	COG3165	ubiquinone biosynthetic process from chorismate
VV93_RS00915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VV93_RS00920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VV93_RS00925	COG0805	protein transport
VV93_RS00930	COG0084	hydrolase, TatD family'
VV93_RS00940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV93_RS00940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV93_RS00960	COG3078	GTPase activator activity
VV93_RS00975	COG3300	MHYT domain
VV93_RS00975	COG5001	Diguanylate cyclase
VV93_RS00985	COG3852	Histidine kinase
VV93_RS00995	COG0174	glutamine synthetase
VV93_RS01000	COG1217	gtp-binding protein TYPA
VV93_RS01015	COG1295	ribonuclease BN
VV93_RS01020	COG1490	D-aminoacyl-tRNA deacylase activity
VV93_RS01025	COG0456	acetyltransferase
VV93_RS01040	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VV93_RS01045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VV93_RS01050	COG3031	protein transport across the cell outer membrane
VV93_RS01060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV93_RS01065	COG1459	type II secretion system
VV93_RS01070	COG2165	general secretion pathway protein
VV93_RS01075	COG2165	general secretion pathway protein
VV93_RS01080	COG2165	general secretion pathway protein
VV93_RS01085	COG4795	General secretion pathway protein
VV93_RS01090	COG3156	type II secretion system protein K
VV93_RS01095	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VV93_RS01100	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VV93_RS01110	COG1218	3'(2'),5'-bisphosphate nucleotidase
VV93_RS01115	COG0494	nUDIX hydrolase
VV93_RS01120	COG0316	Belongs to the HesB IscA family
VV93_RS01120	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VV93_RS01130	COG0596	Alpha beta hydrolase
VV93_RS01140	COG2183	response to ionizing radiation
VV93_RS01145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VV93_RS01160	COG2233	PERMEase
VV93_RS01165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VV93_RS01170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV93_RS01175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV93_RS01180	COG1758	RNA polymerase activity
VV93_RS01185	COG0194	GDP metabolic process
VV93_RS01200	COG0848	biopolymer transport protein
VV93_RS01205	COG0811	peptide transport
VV93_RS01210	COG0811	peptide transport
VV93_RS01220	COG4206	TonB-dependent receptor
VV93_RS01225	COG4174	ABC transporter (Permease)
VV93_RS01230	COG4239	(ABC) transporter, permease
VV93_RS01235	COG0747	negative chemotaxis
VV93_RS01240	COG0444	Belongs to the ABC transporter superfamily
VV93_RS01245	COG4608	Belongs to the ABC transporter superfamily
VV93_RS01290	COG1566	PFAM secretion protein HlyD family protein
VV93_RS01350	COG1061	Type III restriction enzyme res subunit
VV93_RS01420	COG1561	YicC-like family, N-terminal region
VV93_RS01425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VV93_RS01435	COG1560	Kdo2-lipid A biosynthetic process
VV93_RS01440	COG1309	transcriptional regulator
VV93_RS01450	COG0840	transmembrane signaling receptor activity
VV93_RS01455	COG2003	Belongs to the UPF0758 family
VV93_RS01460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VV93_RS01465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VV93_RS01485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VV93_RS01490	COG0859	PFAM glycosyl transferase family 9
VV93_RS01495	COG0463	Glycosyl transferase, family 2
VV93_RS01500	COG0859	PFAM glycosyl transferase family 9
VV93_RS01505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VV93_RS01510	COG3642	lipopolysaccharide core region biosynthetic process
VV93_RS01515	COG3083	sulfuric ester hydrolase activity
VV93_RS01525	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
VV93_RS01535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VV93_RS01545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VV93_RS01555	COG1215	transferase activity, transferring glycosyl groups
VV93_RS01570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV93_RS01575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VV93_RS01580	COG2089	acid synthase
VV93_RS01600	COG1083	cytidylyl-transferase
VV93_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
VV93_RS01620	COG1519	Transferase
VV93_RS01630	COG1560	Kdo2-lipid A biosynthetic process
VV93_RS01640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV93_RS01670	COG1596	polysaccharide export
VV93_RS01685	COG0489	protein tyrosine kinase activity
VV93_RS01685	COG3206	protein involved in exopolysaccharide biosynthesis
VV93_RS01690	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VV93_RS01735	COG0438	transferase activity, transferring glycosyl groups
VV93_RS01740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV93_RS01750	COG2030	dehydratase
VV93_RS01755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV93_RS01765	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
VV93_RS01785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VV93_RS01790	COG3064	Membrane
VV93_RS01805	COG0088	Forms part of the polypeptide exit tunnel
VV93_RS01810	COG0089	rRNA binding
VV93_RS01815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VV93_RS01820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VV93_RS01830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VV93_RS01835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VV93_RS01840	COG0255	Belongs to the universal ribosomal protein uL29 family
VV93_RS01845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VV93_RS01850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VV93_RS01855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VV93_RS01860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VV93_RS01865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VV93_RS01870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VV93_RS01875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VV93_RS01880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VV93_RS01885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VV93_RS01890	COG1841	ribosomal large subunit assembly
VV93_RS01895	COG0200	Binds to the 23S rRNA
VV93_RS01900	COG0201	protein transport
VV93_RS01905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VV93_RS01910	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VV93_RS01915	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VV93_RS01920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VV93_RS01925	COG0202	RNA polymerase activity
VV93_RS01930	COG0203	ribosomal protein L17
VV93_RS01940	COG0545	Peptidyl-prolyl cis-trans isomerase
VV93_RS01945	COG3061	Opacity-associated protein A
VV93_RS01945	COG3266	domain, Protein
VV93_RS01955	COG2153	protein acetylation
VV93_RS01965	COG0737	Belongs to the 5'-nucleotidase family
VV93_RS01970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VV93_RS01970	COG1648	precorrin-2 dehydrogenase activity
VV93_RS01975	COG0175	sulfate reduction
VV93_RS01980	COG2895	sulfate adenylyltransferase (ATP) activity
VV93_RS01985	COG0471	metal ion transport
VV93_RS01985	COG3273	potassium ion transport
VV93_RS01990	COG0529	Catalyzes the synthesis of activated sulfate
VV93_RS02010	COG0577	efflux transmembrane transporter activity
VV93_RS02010	COG1136	(ABC) transporter
VV93_RS02025	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VV93_RS02040	COG0729	surface antigen
VV93_RS02045	COG2911	Protein conserved in bacteria
VV93_RS02050	COG2105	PFAM AIG2 family protein
VV93_RS02060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VV93_RS02065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VV93_RS02070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VV93_RS02075	COG0163	prenyltransferase activity
VV93_RS02080	COG4143	(ABC) transporter
VV93_RS02085	COG1178	ABC-type Fe3 transport system permease component
VV93_RS02090	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VV93_RS02095	COG3028	Belongs to the UPF0307 family
VV93_RS02100	COG0312	modulator of DNA gyrase
VV93_RS02105	COG3335	DDE superfamily endonuclease
VV93_RS02115	COG0312	modulator of DNA gyrase
VV93_RS02120	COG2239	Acts as a magnesium transporter
VV93_RS02125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV93_RS02130	COG1660	Displays ATPase and GTPase activities
VV93_RS02135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV93_RS02140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VV93_RS02150	COG1137	ATPase activity
VV93_RS02155	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VV93_RS02165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VV93_RS02170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VV93_RS02170	COG0517	IMP dehydrogenase activity
VV93_RS02180	COG1127	ABC transporter
VV93_RS02185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VV93_RS02190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VV93_RS02195	COG2854	intermembrane phospholipid transfer
VV93_RS02205	COG5007	Belongs to the BolA IbaG family
VV93_RS02210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VV93_RS02215	COG0204	Acyl-transferase
VV93_RS02220	COG0589	response to stress
VV93_RS02230	COG2358	TRAP transporter, solute receptor (TAXI family
VV93_RS02235	COG1438	arginine binding
VV93_RS02240	COG0039	L-malate dehydrogenase activity
VV93_RS02245	COG0142	geranyltranstransferase activity
VV93_RS02250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VV93_RS02255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VV93_RS02265	COG2966	Psort location CytoplasmicMembrane, score
VV93_RS02270	COG3610	response to peptide
VV93_RS02285	COG2967	ApaG domain
VV93_RS02290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VV93_RS02295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VV93_RS02305	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VV93_RS02320	COG0066	3-isopropylmalate dehydratase activity
VV93_RS02330	COG0473	3-isopropylmalate dehydrogenase activity
VV93_RS02335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VV93_RS02360	COG1022	Amp-dependent synthetase and ligase
VV93_RS02365	COG0028	Belongs to the TPP enzyme family
VV93_RS02370	COG0440	acetolactate synthase activity
VV93_RS02375	COG3706	GGDEF domain
VV93_RS02395	COG1349	DNA-binding transcription factor activity
VV93_RS02405	COG3722	fumarate hydratase activity
VV93_RS02415	COG3335	DDE superfamily endonuclease
VV93_RS02425	COG2213	PTS system mannitol-specific
VV93_RS02425	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV93_RS02430	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VV93_RS02455	COG1518	maintenance of DNA repeat elements
VV93_RS02500	COG2003	Belongs to the UPF0758 family
VV93_RS02515	COG3339	Conserved Protein
VV93_RS02560	COG0582	viral genome integration into host DNA
VV93_RS02580	COG1610	YqeY-like protein
VV93_RS02585	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VV93_RS02590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VV93_RS02595	COG0596	Alpha beta hydrolase
VV93_RS02605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VV93_RS02610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VV93_RS02615	COG1968	undecaprenyl-diphosphatase activity
VV93_RS02620	COG0617	tRNA 3'-terminal CCA addition
VV93_RS02625	COG3409	Peptidoglycan-binding domain 1 protein
VV93_RS02625	COG3267	Type II secretory pathway component ExeA
VV93_RS02630	COG4991	sh3 domain protein
VV93_RS02635	COG0306	phosphate transporter
VV93_RS02640	COG1392	Phosphate transport regulator
VV93_RS02645	COG3025	triphosphatase activity
VV93_RS02650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VV93_RS02670	COG1538	Outer membrane efflux protein
VV93_RS02675	COG0494	nUDIX hydrolase
VV93_RS02680	COG3151	Protein conserved in bacteria
VV93_RS02690	COG3150	esterase
VV93_RS02705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VV93_RS02710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VV93_RS02715	COG3105	Protein conserved in bacteria
VV93_RS02720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VV93_RS02725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VV93_RS02730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VV93_RS02735	COG0723	plastoquinol--plastocyanin reductase activity
VV93_RS02740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VV93_RS02745	COG2857	Cytochrome c1
VV93_RS02750	COG0625	glutathione transferase activity
VV93_RS02755	COG2969	positive regulation of protein catabolic process
VV93_RS02760	COG2823	Periplasmic or secreted lipoprotein
VV93_RS02765	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VV93_RS02770	COG0792	nuclease activity
VV93_RS02775	COG3107	peptidoglycan biosynthetic process
VV93_RS02780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VV93_RS02785	COG0275	rRNA processing
VV93_RS02790	COG3116	cell division
VV93_RS02795	COG0768	penicillin binding
VV93_RS02800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VV93_RS02805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VV93_RS02810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VV93_RS02815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VV93_RS02820	COG0772	Belongs to the SEDS family
VV93_RS02830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VV93_RS02835	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VV93_RS02840	COG0849	cell division
VV93_RS02845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VV93_RS02850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VV93_RS02860	COG0653	protein targeting
VV93_RS02865	COG0494	nUDIX hydrolase
VV93_RS02875	COG0505	Belongs to the CarA family
VV93_RS02880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VV93_RS02890	COG0730	response to heat
VV93_RS02895	COG0583	DNA-binding transcription factor activity
VV93_RS02900	COG2860	membrane
VV93_RS02905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VV93_RS02915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VV93_RS02925	COG0493	'glutamate synthase
VV93_RS02930	COG0070	glutamate synthase
VV93_RS02930	COG0069	glutamate synthase activity
VV93_RS02930	COG0067	glutamate synthase
VV93_RS02940	COG0069	glutamate synthase activity
VV93_RS02940	COG0070	glutamate synthase
VV93_RS02940	COG0067	glutamate synthase
VV93_RS02945	COG1242	4 iron, 4 sulfur cluster binding
VV93_RS02950	COG2203	Gaf domain
VV93_RS02950	COG4251	negative regulation of phosphorylation
VV93_RS02950	COG3706	GGDEF domain
VV93_RS02950	COG5001	Diguanylate cyclase
VV93_RS02955	COG2198	Histidine kinase
VV93_RS02955	COG5002	protein histidine kinase activity
VV93_RS02955	COG0784	Response regulator, receiver
VV93_RS02965	COG0745	RESPONSE REGULATOR receiver
VV93_RS02975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VV93_RS02990	COG0083	homoserine kinase activity
VV93_RS02995	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VV93_RS03000	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VV93_RS03010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VV93_RS03025	COG1115	amino acid carrier protein
VV93_RS03035	COG0513	Belongs to the DEAD box helicase family
VV93_RS03040	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VV93_RS03055	COG4974	Belongs to the 'phage' integrase family
VV93_RS03060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VV93_RS03065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VV93_RS03070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VV93_RS03075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VV93_RS03090	COG0667	Aldo Keto reductase
VV93_RS03100	COG3066	DNA modification
VV93_RS03105	COG0494	nUDIX hydrolase
VV93_RS03115	COG0730	response to heat
VV93_RS03135	COG1283	sodium-dependent phosphate transmembrane transporter activity
VV93_RS03140	COG0583	DNA-binding transcription factor activity
VV93_RS03145	COG0640	Transcriptional regulator
VV93_RS03150	COG0268	Binds directly to 16S ribosomal RNA
VV93_RS03155	COG0728	peptidoglycan biosynthetic process
VV93_RS03160	COG0196	riboflavin kinase activity
VV93_RS03165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VV93_RS03170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VV93_RS03175	COG1047	Peptidyl-prolyl cis-trans
VV93_RS03180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VV93_RS03190	COG3275	phosphorelay sensor kinase activity
VV93_RS03195	COG1966	Carbon starvation protein
VV93_RS03215	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VV93_RS03230	COG0287	Prephenate dehydrogenase
VV93_RS03230	COG1605	Chorismate mutase
VV93_RS03235	COG0739	heme binding
VV93_RS03245	COG0488	(ABC) transporter
VV93_RS03255	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VV93_RS03260	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VV93_RS03265	COG1605	Chorismate mutase
VV93_RS03265	COG0077	Prephenate dehydratase
VV93_RS03270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VV93_RS03275	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV93_RS03290	COG0542	response to heat
VV93_RS03385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VV93_RS03390	COG0826	peptidase U32
VV93_RS03400	COG0745	RESPONSE REGULATOR receiver
VV93_RS03405	COG5002	protein histidine kinase activity
VV93_RS03415	COG0248	Ppx GppA phosphatase
VV93_RS03425	COG0573	inorganic phosphate transmembrane transporter activity
VV93_RS03430	COG0581	inorganic phosphate transmembrane transporter activity
VV93_RS03435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VV93_RS03440	COG0704	Plays a role in the regulation of phosphate uptake
VV93_RS03475	COG0450	alkyl hydroperoxide reductase
VV93_RS03480	COG0583	DNA-binding transcription factor activity
VV93_RS03485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VV93_RS03495	COG0517	IMP dehydrogenase activity
VV93_RS03505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VV93_RS03510	COG0343	queuine tRNA-ribosyltransferase activity
VV93_RS03515	COG1862	Preprotein translocase
VV93_RS03520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV93_RS03525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV93_RS03540	COG0483	inositol monophosphate 1-phosphatase activity
VV93_RS03545	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VV93_RS03550	COG1959	2 iron, 2 sulfur cluster binding
VV93_RS03560	COG0822	iron-sulfur transferase activity
VV93_RS03565	COG0316	Belongs to the HesB IscA family
VV93_RS03575	COG0443	Heat shock 70 kDa protein
VV93_RS03580	COG0633	Ferredoxin
VV93_RS03585	COG2975	iron-sulfur cluster assembly
VV93_RS03590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VV93_RS03595	COG0105	UTP biosynthetic process
VV93_RS03600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VV93_RS03610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VV93_RS03615	COG0124	histidyl-tRNA synthetase
VV93_RS03620	COG2976	Protein conserved in bacteria
VV93_RS03625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV93_RS03630	COG1160	GTP binding
VV93_RS03640	COG2199	diguanylate cyclase activity
VV93_RS03640	COG2203	Gaf domain
VV93_RS03655	COG0517	IMP dehydrogenase activity
VV93_RS03655	COG0516	GMP reductase activity
VV93_RS03670	COG1584	GPR1 FUN34 yaaH family protein
VV93_RS03675	COG1115	amino acid carrier protein
VV93_RS03685	COG0583	DNA-binding transcription factor activity
VV93_RS03705	COG0009	L-threonylcarbamoyladenylate synthase
VV93_RS03775	COG0328	RNA-DNA hybrid ribonuclease activity
VV93_RS03815	COG2003	Belongs to the UPF0758 family
VV93_RS03845	COG0582	viral genome integration into host DNA
VV93_RS03850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VV93_RS03855	COG2867	negative regulation of translational initiation
VV93_RS03860	COG2914	Belongs to the UPF0125 (RnfH) family
VV93_RS03865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV93_RS03870	COG0497	DNA recombination
VV93_RS03875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VV93_RS03880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VV93_RS03885	COG3335	DDE superfamily endonuclease
VV93_RS03920	COG0443	Heat shock 70 kDa protein
VV93_RS03925	COG0484	heat shock protein binding
VV93_RS03935	COG4969	Belongs to the N-Me-Phe pilin family
VV93_RS03955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VV93_RS03960	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VV93_RS03970	COG0583	DNA-binding transcription factor activity
VV93_RS03980	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VV93_RS04010	COG2195	Cleaves the N-terminal amino acid of tripeptides
VV93_RS04015	COG2252	PERMEase
VV93_RS04020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VV93_RS04025	COG1073	alpha beta
VV93_RS04035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VV93_RS04045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VV93_RS04050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VV93_RS04050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VV93_RS04065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VV93_RS04070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VV93_RS04075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VV93_RS04080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VV93_RS04085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VV93_RS04090	COG0142	geranyltranstransferase activity
VV93_RS04095	COG1722	exodeoxyribonuclease VII activity
VV93_RS04100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VV93_RS04115	COG0583	DNA-binding transcription factor activity
VV93_RS04125	COG2363	Small membrane protein
VV93_RS04140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV93_RS04145	COG1611	Belongs to the LOG family
VV93_RS04170	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VV93_RS04175	COG1464	Belongs to the NlpA lipoprotein family
VV93_RS04180	COG2011	ABC-type metal ion transport system permease component
VV93_RS04190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VV93_RS04200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV93_RS04200	COG1263	PTS System
VV93_RS04205	COG0366	Alpha amylase catalytic
VV93_RS04215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VV93_RS04225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VV93_RS04230	COG0321	lipoyl(octanoyl) transferase activity
VV93_RS04235	COG2921	Belongs to the UPF0250 family
VV93_RS04240	COG1686	Belongs to the peptidase S11 family
VV93_RS04245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VV93_RS04250	COG0772	Belongs to the SEDS family
VV93_RS04255	COG0768	penicillin binding
VV93_RS04260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VV93_RS04265	COG0799	negative regulation of ribosome biogenesis
VV93_RS04270	COG1466	dna polymerase III delta subunit
VV93_RS04275	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VV93_RS04285	COG2888	peptidyl-tyrosine sulfation
VV93_RS04295	COG4535	Mg2 and Co2 transporter CorC
VV93_RS04300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VV93_RS04305	COG1702	phosphate starvation-inducible protein PhoH
VV93_RS04315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV93_RS04400	COG0193	aminoacyl-tRNA hydrolase activity
VV93_RS04405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VV93_RS04410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VV93_RS04420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VV93_RS04425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VV93_RS04430	COG2890	protein-(glutamine-N5) methyltransferase activity
VV93_RS04440	COG2912	Transglutaminase-like superfamily
VV93_RS04445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VV93_RS04460	COG1187	pseudouridine synthase activity
VV93_RS04465	COG2840	Smr protein MutS2
VV93_RS04480	COG3735	TraB family
VV93_RS04495	COG2217	Heavy metal translocating P-type atpase
VV93_RS04495	COG2608	mercury ion transmembrane transporter activity
VV93_RS04555	COG0784	Response regulator, receiver
VV93_RS04555	COG0835	chemotaxis
VV93_RS04560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VV93_RS04565	COG1815	bacterial-type flagellum-dependent cell motility
VV93_RS04580	COG1749	Flagellar hook protein flgE
VV93_RS04585	COG4787	bacterial-type flagellum-dependent cell motility
VV93_RS04595	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VV93_RS04600	COG1706	bacterial-type flagellum-dependent cell motility
VV93_RS04605	COG1705	Flagellar rod assembly protein muramidase FlgJ
VV93_RS04605	COG3951	Flagellar rod assembly protein muramidase FlgJ
VV93_RS04615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV93_RS04620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV93_RS04630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV93_RS04635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV93_RS04640	COG2190	(PTS) system
VV93_RS04645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VV93_RS04650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV93_RS04655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VV93_RS04660	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VV93_RS04690	COG0330	HflC and HflK could
VV93_RS04695	COG3118	belongs to the thioredoxin family
VV93_RS04700	COG0300	oxidoreductase activity
VV93_RS04705	COG1090	epimerase
VV93_RS04730	COG0622	Phosphoesterase
VV93_RS04750	COG3710	Transcriptional regulator
VV93_RS04765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VV93_RS04770	COG0840	transmembrane signaling receptor activity
VV93_RS04775	COG3104	oligopeptide transport
VV93_RS04785	COG0367	asparagine synthase
VV93_RS04790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VV93_RS04790	COG4651	solute:proton antiporter activity
VV93_RS04795	COG1846	Transcriptional regulator
VV93_RS04795	COG1940	carbohydrate kinase activity
VV93_RS04800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VV93_RS04805	COG1263	PTS System
VV93_RS04805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV93_RS04805	COG2190	(PTS) system
VV93_RS04810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV93_RS04825	COG0716	FMN binding
VV93_RS04835	COG0596	Alpha beta hydrolase
VV93_RS04840	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VV93_RS04845	COG0033	Phosphoglucomutase
VV93_RS04850	COG2964	Protein conserved in bacteria
VV93_RS04855	COG0251	oxidation-reduction process
VV93_RS04865	COG0446	pyridine nucleotide-disulphide oxidoreductase
VV93_RS04875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VV93_RS04885	COG2009	succinate dehydrogenase
VV93_RS04890	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VV93_RS04895	COG1053	succinate dehydrogenase
VV93_RS04905	COG0567	Dehydrogenase, E1 component
VV93_RS04910	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV93_RS04925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VV93_RS04930	COG1121	(ABC) transporter
VV93_RS04935	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VV93_RS04945	COG1918	ferrous iron import across plasma membrane
VV93_RS04970	COG3102	Protein conserved in bacteria
VV93_RS04975	COG0788	formyltetrahydrofolate deformylase activity
VV93_RS04985	COG1199	ATP-dependent helicase activity
VV93_RS04990	COG1214	PFAM Peptidase M22, glycoprotease
VV93_RS05005	COG0596	Alpha beta hydrolase
VV93_RS05010	COG0318	PFAM AMP-dependent synthetase and ligase
VV93_RS05015	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VV93_RS05020	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VV93_RS05025	COG2894	cell division
VV93_RS05030	COG0850	regulation of cytokinetic process
VV93_RS05040	COG2951	lytic endotransglycosylase activity
VV93_RS05050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VV93_RS05060	COG0745	RESPONSE REGULATOR receiver
VV93_RS05065	COG5002	protein histidine kinase activity
VV93_RS05080	COG1028	Short-chain dehydrogenase reductase Sdr
VV93_RS05085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VV93_RS05090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VV93_RS05115	COG2986	histidine ammonia-lyase
VV93_RS05120	COG1216	Glycosyl transferase, family 2
VV93_RS05130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VV93_RS05140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV93_RS05145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV93_RS05205	COG1175	transmembrane transport
VV93_RS05215	COG3842	ATPase activity
VV93_RS05220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VV93_RS05225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VV93_RS05230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VV93_RS05240	COG2204	response regulator
VV93_RS05245	COG4191	Histidine kinase
VV93_RS05260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VV93_RS05265	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VV93_RS05270	COG0776	regulation of translation
VV93_RS05275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VV93_RS05280	COG1555	photosystem II stabilization
VV93_RS05295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VV93_RS05300	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VV93_RS05305	COG0436	Aminotransferase
VV93_RS05310	COG1169	isochorismate synthase
VV93_RS05325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VV93_RS05335	COG0318	PFAM AMP-dependent synthetase and ligase
VV93_RS05390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV93_RS05395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV93_RS05410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VV93_RS05415	COG1522	sequence-specific DNA binding
VV93_RS05425	COG1946	Acyl-CoA thioesterase
VV93_RS05430	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VV93_RS05445	COG5001	Diguanylate cyclase
VV93_RS05475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VV93_RS05490	COG3139	Protein of unknown function (DUF1315)
VV93_RS05495	COG0252	asparaginase activity
VV93_RS05500	COG0616	signal peptide processing
VV93_RS05505	COG1902	pentaerythritol trinitrate reductase activity
VV93_RS05505	COG0446	pyridine nucleotide-disulphide oxidoreductase
VV93_RS05510	COG0778	Nitroreductase
VV93_RS05515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VV93_RS05520	COG0123	including yeast histone deacetylase and acetoin utilization protein
VV93_RS05530	COG3335	DDE superfamily endonuclease
VV93_RS05550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VV93_RS05555	COG2731	YhcH YjgK YiaL family protein
VV93_RS05560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV93_RS05565	COG0569	domain protein
VV93_RS05575	COG3083	sulfuric ester hydrolase activity
VV93_RS05585	COG3081	Nucleoid-associated protein
VV93_RS05600	COG1757	Na H antiporter
VV93_RS05605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VV93_RS05615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV93_RS05620	COG2095	MarC family integral membrane protein
VV93_RS05625	COG1454	alcohol dehydrogenase
VV93_RS05625	COG1012	belongs to the aldehyde dehydrogenase family
VV93_RS05630	COG1028	Short-chain dehydrogenase reductase Sdr
VV93_RS05645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VV93_RS05655	COG2056	Na+-H+ antiporter family
VV93_RS05660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VV93_RS05665	COG2885	chlorophyll binding
VV93_RS05675	COG0346	lactoylglutathione lyase activity
VV93_RS05680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VV93_RS05685	COG4660	Part of a membrane complex involved in electron transport
VV93_RS05690	COG4659	FMN binding
VV93_RS05695	COG4658	electron transport chain
VV93_RS05700	COG4656	Part of a membrane complex involved in electron transport
VV93_RS05705	COG2878	Part of a membrane complex involved in electron transport
VV93_RS05710	COG4657	Part of a membrane complex involved in electron transport
VV93_RS05720	COG0556	nucleotide-excision repair
VV93_RS05725	COG2204	response regulator
VV93_RS05730	COG2198	Histidine kinase
VV93_RS05735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VV93_RS05745	COG0521	Mo-molybdopterin cofactor biosynthetic process
VV93_RS05755	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VV93_RS05760	COG0314	molybdopterin synthase activity
VV93_RS05770	COG0601	transmembrane transport
VV93_RS05775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV93_RS05780	COG0444	Belongs to the ABC transporter superfamily
VV93_RS05790	COG0435	Glutathione S-transferase
VV93_RS05800	COG2350	Protein conserved in bacteria
VV93_RS05820	COG1301	dicarboxylic acid transport
VV93_RS05830	COG0133	tryptophan synthase activity
VV93_RS05835	COG0135	phosphoribosylanthranilate isomerase activity
VV93_RS05835	COG0134	indole-3-glycerol-phosphate synthase activity
VV93_RS05845	COG0512	Glutamine amidotransferase of anthranilate synthase
VV93_RS05850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VV93_RS05860	COG0613	PHP domain protein
VV93_RS05865	COG0009	L-threonylcarbamoyladenylate synthase
VV93_RS05885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VV93_RS05895	COG5001	Diguanylate cyclase
VV93_RS05900	COG0417	DNA replication proofreading
VV93_RS05905	COG2197	response regulator
VV93_RS05940	COG3335	DDE superfamily endonuclease
VV93_RS05985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV93_RS05990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV93_RS05995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VV93_RS06020	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VV93_RS06025	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VV93_RS06030	COG0437	4 iron, 4 sulfur cluster binding
VV93_RS06035	COG3301	Polysulphide reductase, NrfD
VV93_RS06040	COG1138	Cytochrome C-type biogenesis protein
VV93_RS06045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VV93_RS06050	COG3088	subunit of a heme lyase
VV93_RS06050	COG4235	cytochrome complex assembly
VV93_RS06065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV93_RS06065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV93_RS06070	COG0489	protein tyrosine kinase activity
VV93_RS06075	COG0572	uridine kinase
VV93_RS06085	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VV93_RS06090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VV93_RS06095	COG0659	secondary active sulfate transmembrane transporter activity
VV93_RS06100	COG1530	ribonuclease E activity
VV93_RS06110	COG0424	maF-like protein
VV93_RS06115	COG1399	metal-binding, possibly nucleic acid-binding protein
VV93_RS06120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VV93_RS06125	COG0416	fatty acid biosynthetic process
VV93_RS06130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VV93_RS06145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV93_RS06160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VV93_RS06165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VV93_RS06175	COG0084	hydrolase, TatD family'
VV93_RS06180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV93_RS06180	COG1263	PTS System
VV93_RS06190	COG0733	neurotransmitter:sodium symporter activity
VV93_RS06200	COG4667	esterase of the alpha-beta hydrolase superfamily
VV93_RS06205	COG0469	pyruvate kinase activity
VV93_RS06210	COG1940	carbohydrate kinase activity
VV93_RS06215	COG0784	Response regulator, receiver
VV93_RS06215	COG0835	chemotaxis
VV93_RS06235	COG1028	Short-chain dehydrogenase reductase Sdr
VV93_RS06240	COG0616	signal peptide processing
VV93_RS06250	COG0539	negative regulation of cytoplasmic translation
VV93_RS06260	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VV93_RS06265	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VV93_RS06270	COG0284	orotidine-5'-phosphate decarboxylase activity
VV93_RS06275	COG4174	ABC transporter (Permease)
VV93_RS06280	COG4239	(ABC) transporter, permease
VV93_RS06285	COG4166	transmembrane transport
VV93_RS06290	COG0444	Belongs to the ABC transporter superfamily
VV93_RS06295	COG4608	Belongs to the ABC transporter superfamily
VV93_RS06330	COG0583	DNA-binding transcription factor activity
VV93_RS06340	COG0686	Belongs to the AlaDH PNT family
VV93_RS06355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VV93_RS06360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VV93_RS06375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VV93_RS06390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VV93_RS06395	COG0501	Belongs to the peptidase M48B family
VV93_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
VV93_RS06420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VV93_RS06440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VV93_RS06445	COG2915	High frequency lysogenization protein hflD homolog
VV93_RS06450	COG0482	sulfurtransferase activity
VV93_RS06460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV93_RS06465	COG2916	Histone family protein nucleoid-structuring protein H-NS
VV93_RS06470	COG1757	Na H antiporter
VV93_RS06475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VV93_RS06480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VV93_RS06485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VV93_RS06495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VV93_RS06505	COG0107	imidazoleglycerol-phosphate synthase activity
VV93_RS06515	COG3012	SEC-C Motif Domain Protein
VV93_RS06520	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VV93_RS06525	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV93_RS06530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VV93_RS06535	COG0215	cysteine-tRNA ligase activity
VV93_RS06540	COG1435	thymidine kinase activity
VV93_RS06550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VV93_RS06555	COG0583	DNA-binding transcription factor activity
VV93_RS06575	COG2116	formate transmembrane transporter activity
VV93_RS06580	COG0390	transport system, permease component
VV93_RS06585	COG4459	periplasmic nitrate reductase
VV93_RS06590	COG3005	denitrification pathway
VV93_RS06630	COG1227	inorganic diphosphatase activity
VV93_RS06645	COG4172	Belongs to the ABC transporter superfamily
VV93_RS06670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VV93_RS06675	COG1842	Phage shock protein A
VV93_RS06685	COG1983	PspC domain protein
VV93_RS06705	COG2818	Glycosylase
VV93_RS06710	COG0626	cystathionine gamma-synthase activity
VV93_RS06720	COG0733	neurotransmitter:sodium symporter activity
VV93_RS06730	COG0564	pseudouridine synthase activity
VV93_RS06745	COG3335	DDE superfamily endonuclease
VV93_RS06750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VV93_RS06755	COG1151	hydroxylamine reductase activity
VV93_RS06760	COG3604	Transcriptional regulator
VV93_RS06765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VV93_RS06770	COG4136	ATPase activity
VV93_RS06775	COG4135	transport system, permease component
VV93_RS06780	COG4134	Bacterial extracellular solute-binding protein
VV93_RS06790	COG3313	Fe-S protein
VV93_RS06815	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VV93_RS06820	COG2205	protein histidine kinase activity
VV93_RS06835	COG1061	Type III restriction enzyme res subunit
VV93_RS06845	COG3335	DDE superfamily endonuclease
VV93_RS06855	COG2814	Major facilitator Superfamily
VV93_RS06870	COG0702	epimerase
VV93_RS06875	COG1136	(ABC) transporter
VV93_RS06890	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VV93_RS06910	COG3273	potassium ion transport
VV93_RS06910	COG2985	domain, Protein
VV93_RS06915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VV93_RS06920	COG1979	alcohol dehydrogenase
VV93_RS06925	COG1737	Transcriptional regulator
VV93_RS06930	COG0076	glutamate decarboxylase activity
VV93_RS06940	COG2431	L-lysine efflux transmembrane transporter activity
VV93_RS06950	COG3070	regulator of competence-specific genes
VV93_RS06965	COG5002	protein histidine kinase activity
VV93_RS06965	COG5002	protein histidine kinase activity
VV93_RS06975	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VV93_RS06980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VV93_RS06985	COG4988	ABC transporter
VV93_RS06990	COG0492	ferredoxin-NADP+ reductase activity
VV93_RS07015	COG0471	metal ion transport
VV93_RS07020	COG2949	membrane
VV93_RS07025	COG0281	malic enzyme
VV93_RS07030	COG1643	Atp-dependent helicase
VV93_RS07045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VV93_RS07055	COG1346	cytolysis
VV93_RS07060	COG1380	Effector of murein hydrolase LrgA
VV93_RS07065	COG2925	Exonuclease
VV93_RS07085	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VV93_RS07105	COG2988	succinylglutamate desuccinylase activity
VV93_RS07115	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VV93_RS07135	COG0583	DNA-binding transcription factor activity
VV93_RS07145	COG1451	nucleotide metabolic process
VV93_RS07160	COG3063	Type IV pilus biogenesis stability protein PilW
VV93_RS07175	COG2195	Cleaves the N-terminal amino acid of tripeptides
VV93_RS07185	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VV93_RS07195	COG0625	glutathione transferase activity
VV93_RS07235	COG1278	Cold shock
VV93_RS07245	COG0584	glycerophosphoryl diester phosphodiesterase
VV93_RS07250	COG1349	DNA-binding transcription factor activity
VV93_RS07255	COG3842	ATPase activity
VV93_RS07260	COG0395	ABC-type sugar transport system, permease component
VV93_RS07265	COG1175	transmembrane transport
VV93_RS07270	COG1653	transport
VV93_RS07285	COG0730	response to heat
VV93_RS07295	COG2197	response regulator
VV93_RS07335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VV93_RS07345	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VV93_RS07350	COG0372	Belongs to the citrate synthase family
VV93_RS07355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VV93_RS07360	COG2828	Protein conserved in bacteria
VV93_RS07400	COG0561	phosphatase activity
VV93_RS07405	COG0602	queuosine metabolic process
VV93_RS07410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VV93_RS07415	COG3706	GGDEF domain
VV93_RS07440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VV93_RS07450	COG1254	Belongs to the acylphosphatase family
VV93_RS07455	COG2920	part of a sulfur-relay system
VV93_RS07465	COG0670	Belongs to the BI1 family
VV93_RS07470	COG1126	abc transporter atp-binding protein
VV93_RS07475	COG0765	amino acid transport
VV93_RS07480	COG4597	amino acid ABC transporter
VV93_RS07485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV93_RS07495	COG0437	4 iron, 4 sulfur cluster binding
VV93_RS07500	COG0348	domain, Protein
VV93_RS07505	COG0204	Acyl-transferase
VV93_RS07510	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VV93_RS07525	COG1115	amino acid carrier protein
VV93_RS07555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV93_RS07570	COG3290	protein histidine kinase activity
VV93_RS07575	COG4565	transcriptional regulatory protein
VV93_RS07580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VV93_RS07585	COG0363	glucosamine-6-phosphate deaminase activity
VV93_RS07590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VV93_RS07620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV93_RS07630	COG0438	transferase activity, transferring glycosyl groups
VV93_RS07675	COG2204	response regulator
VV93_RS07705	COG1366	Belongs to the anti-sigma-factor antagonist family
VV93_RS07710	COG1793	dna ligase
VV93_RS07715	COG3706	GGDEF domain
VV93_RS07725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VV93_RS07740	COG2996	Protein conserved in bacteria
VV93_RS07745	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VV93_RS07745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VV93_RS07750	COG3008	intermembrane lipid transfer
VV93_RS07755	COG2995	paraquat-inducible protein a
VV93_RS07760	COG1132	(ABC) transporter
VV93_RS07765	COG1956	GAF domain-containing protein
VV93_RS07770	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VV93_RS07785	COG0308	aminopeptidase N
VV93_RS07790	COG2902	Dehydrogenase
VV93_RS07805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VV93_RS07805	COG0116	Belongs to the methyltransferase superfamily
VV93_RS07815	COG0488	(ABC) transporter
VV93_RS07830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VV93_RS07835	COG1067	ATP-dependent peptidase activity
VV93_RS07840	COG3120	sequence-specific DNA binding
VV93_RS07945	COG2205	protein histidine kinase activity
VV93_RS07945	COG0784	Response regulator, receiver
VV93_RS07960	COG3278	Belongs to the heme-copper respiratory oxidase family
VV93_RS07975	COG2010	Cytochrome c
VV93_RS07985	COG2217	Heavy metal translocating P-type atpase
VV93_RS08000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV93_RS08005	COG0589	response to stress
VV93_RS08010	COG0037	tRNA processing
VV93_RS08020	COG2992	FlgJ-related protein
VV93_RS08030	COG3842	ATPase activity
VV93_RS08035	COG1176	ABC-type spermidine putrescine transport system, permease component I
VV93_RS08040	COG1177	transmembrane transport
VV93_RS08050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VV93_RS08055	COG3385	transposase activity
VV93_RS08060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VV93_RS08065	COG0004	ammonium transporteR
VV93_RS08105	COG0437	4 iron, 4 sulfur cluster binding
VV93_RS08110	COG0243	molybdopterin cofactor binding
VV93_RS08110	COG3383	formate dehydrogenase (NAD+) activity
VV93_RS08140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VV93_RS08145	COG0840	transmembrane signaling receptor activity
VV93_RS08150	COG0488	(ABC) transporter
VV93_RS08165	COG3852	Histidine kinase
VV93_RS08170	COG2204	response regulator
VV93_RS08180	COG4662	Binding-protein-dependent transport system inner membrane component
VV93_RS08185	COG3842	ATPase activity
VV93_RS08195	COG0303	'Molybdopterin
VV93_RS08205	COG1940	carbohydrate kinase activity
VV93_RS08210	COG3148	PFAM DTW domain containing protein
VV93_RS08220	COG0840	transmembrane signaling receptor activity
VV93_RS08225	COG0791	NLP P60 protein
VV93_RS08235	COG3706	GGDEF domain
VV93_RS08255	COG0307	riboflavin synthase, alpha
VV93_RS08260	COG0534	Mate efflux family protein
VV93_RS08290	COG2801	Transposase and inactivated derivatives
VV93_RS08320	COG4115	mRNA cleavage
VV93_RS08325	COG2161	toxin-antitoxin pair type II binding
VV93_RS08340	COG2026	Addiction module toxin, RelE StbE family
VV93_RS08410	COG4628	conserved protein (DUF2132)
VV93_RS08450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV93_RS08580	COG3335	DDE superfamily endonuclease
VV93_RS08600	COG2944	sequence-specific DNA binding
VV93_RS08605	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VV93_RS08675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VV93_RS08695	COG4326	sporulation control protein
VV93_RS08705	COG1228	amidohydrolase
VV93_RS08715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VV93_RS08720	COG2986	histidine ammonia-lyase
VV93_RS08730	COG5640	endopeptidase activity
VV93_RS08735	COG2020	methyltransferase activity
VV93_RS08740	COG0277	FAD linked oxidase domain protein
VV93_RS08740	COG0247	lactate metabolic process
VV93_RS08755	COG2885	chlorophyll binding
VV93_RS08775	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VV93_RS08780	COG0500	methyltransferase
VV93_RS08790	COG0776	regulation of translation
VV93_RS08815	COG3335	DDE superfamily endonuclease
VV93_RS08820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV93_RS08820	COG0072	phenylalanine-tRNA ligase activity
VV93_RS08825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VV93_RS08890	COG1166	arginine decarboxylase activity
VV93_RS08895	COG0010	Belongs to the arginase family
VV93_RS08900	COG0840	transmembrane signaling receptor activity
VV93_RS08915	COG2814	Major facilitator Superfamily
VV93_RS08920	COG5380	lipid catabolic process
VV93_RS08925	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VV93_RS08950	COG1643	Atp-dependent helicase
VV93_RS08960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VV93_RS09000	COG2894	cell division
VV93_RS09010	COG4964	Belongs to the GSP D family
VV93_RS09035	COG3335	DDE superfamily endonuclease
VV93_RS09055	COG3713	MltA-interacting MipA family protein
VV93_RS09075	COG3706	GGDEF domain
VV93_RS09085	COG0443	Heat shock 70 kDa protein
VV93_RS09090	COG0443	Heat shock 70 kDa protein
VV93_RS09115	COG2165	general secretion pathway protein
VV93_RS09130	COG0297	glycogen (starch) synthase activity
VV93_RS09130	COG0438	transferase activity, transferring glycosyl groups
VV93_RS09160	COG3335	DDE superfamily endonuclease
VV93_RS09175	COG1596	polysaccharide export
VV93_RS09185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV93_RS09190	COG1115	amino acid carrier protein
VV93_RS09195	COG1132	(ABC) transporter
VV93_RS09200	COG1132	(ABC) transporter
VV93_RS09215	COG0783	Belongs to the Dps family
VV93_RS09230	COG0814	amino acid
VV93_RS09235	COG1597	lipid kinase activity
VV93_RS09245	COG4667	esterase of the alpha-beta hydrolase superfamily
VV93_RS09250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VV93_RS09265	COG0583	DNA-binding transcription factor activity
VV93_RS09270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VV93_RS09275	COG1328	CTP reductase activity
VV93_RS09280	COG5001	Diguanylate cyclase
VV93_RS09280	COG3300	MHYT domain
VV93_RS09300	COG2199	diguanylate cyclase activity
VV93_RS09300	COG2200	EAL domain
VV93_RS09305	COG3706	GGDEF domain
VV93_RS09315	COG4191	Histidine kinase
VV93_RS09315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV93_RS09320	COG0471	metal ion transport
VV93_RS09335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV93_RS09340	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VV93_RS09345	COG3768	UPF0283 membrane protein
VV93_RS09350	COG3106	COG3106 Predicted ATPase
VV93_RS09365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VV93_RS09370	COG2205	protein histidine kinase activity
VV93_RS09370	COG0784	Response regulator, receiver
VV93_RS09380	COG0494	nUDIX hydrolase
VV93_RS09385	COG0814	amino acid
VV93_RS09390	COG1760	l-serine dehydratase
VV93_RS09395	COG2200	EAL domain
VV93_RS09405	COG0720	synthase
VV93_RS09410	COG0840	transmembrane signaling receptor activity
VV93_RS09415	COG0017	Asparaginyl-tRNA synthetase
VV93_RS09425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV93_RS09440	COG3437	response regulator, receiver
VV93_RS09440	COG2770	Histidine kinase
VV93_RS09450	COG3335	DDE superfamily endonuclease
VV93_RS09455	COG2770	Histidine kinase
VV93_RS09455	COG3437	response regulator, receiver
VV93_RS09460	COG1448	Aminotransferase
VV93_RS09485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VV93_RS09490	COG1846	Transcriptional regulator
VV93_RS09515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VV93_RS09530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV93_RS09535	COG3108	Peptidase M15
VV93_RS09540	COG2989	Protein conserved in bacteria
VV93_RS09570	COG2186	Transcriptional regulator
VV93_RS09575	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VV93_RS09585	COG0653	protein targeting
VV93_RS09600	COG0366	Alpha amylase catalytic
VV93_RS09610	COG4120	Belongs to the binding-protein-dependent transport system permease family
VV93_RS09620	COG3092	negative regulation of chromosome organization
VV93_RS09625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VV93_RS09630	COG0280	phosphate acetyltransferase
VV93_RS09630	COG0857	belongs to the CobB CobQ family
VV93_RS09640	COG0583	DNA-binding transcription factor activity
VV93_RS09665	COG1032	radical SAM domain protein
VV93_RS09685	COG2207	Transcriptional regulator
VV93_RS09700	COG0861	Integral membrane protein TerC family
VV93_RS09705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV93_RS09710	COG1454	alcohol dehydrogenase
VV93_RS09715	COG0235	Class ii aldolase
VV93_RS09720	COG4154	Belongs to the RbsD FucU family
VV93_RS09725	COG1070	Carbohydrate kinase
VV93_RS09730	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
VV93_RS09735	COG0738	Major facilitator superfamily
VV93_RS09740	COG1349	DNA-binding transcription factor activity
VV93_RS09750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VV93_RS09765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VV93_RS09860	COG2199	diguanylate cyclase activity
VV93_RS09870	COG2610	gluconate transmembrane transporter activity
VV93_RS09875	COG3622	Belongs to the hyi family
VV93_RS09880	COG0235	Class ii aldolase
VV93_RS09885	COG3395	kinase activity
VV93_RS09890	COG2084	Dehydrogenase
VV93_RS09895	COG1349	DNA-binding transcription factor activity
VV93_RS09910	COG2003	Belongs to the UPF0758 family
VV93_RS09925	COG0328	RNA-DNA hybrid ribonuclease activity
VV93_RS09965	COG0582	viral genome integration into host DNA
VV93_RS10000	COG0784	Response regulator, receiver
VV93_RS10000	COG2205	protein histidine kinase activity
VV93_RS10010	COG0754	glutathionylspermidine amidase activity
VV93_RS10020	COG3766	membrane
VV93_RS10030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VV93_RS10035	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VV93_RS10040	COG2885	chlorophyll binding
VV93_RS10045	COG0823	Involved in the tonB-independent uptake of proteins
VV93_RS10060	COG0811	peptide transport
VV93_RS10065	COG0824	Thioesterase
VV93_RS10080	COG1294	oxidase, subunit
VV93_RS10085	COG1271	oxidase subunit
VV93_RS10090	COG2255	four-way junction helicase activity
VV93_RS10095	COG0632	four-way junction helicase activity
VV93_RS10100	COG0840	transmembrane signaling receptor activity
VV93_RS10105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VV93_RS10110	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VV93_RS10120	COG4106	trans-aconitate 2-methyltransferase activity
VV93_RS10125	COG0500	methyltransferase
VV93_RS10130	COG4067	protein conserved in archaea
VV93_RS10130	COG0189	ligase activity
VV93_RS10145	COG3335	DDE superfamily endonuclease
VV93_RS10175	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VV93_RS10185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VV93_RS10190	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VV93_RS10195	COG0745	RESPONSE REGULATOR receiver
VV93_RS10200	COG3381	protein complex oligomerization
VV93_RS10205	COG1609	Transcriptional regulator
VV93_RS10210	COG3070	regulator of competence-specific genes
VV93_RS10230	COG0297	glycogen (starch) synthase activity
VV93_RS10235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VV93_RS10240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VV93_RS10255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VV93_RS10270	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VV93_RS10275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VV93_RS10280	COG0542	response to heat
VV93_RS10285	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VV93_RS10290	COG1278	Cold shock
VV93_RS10310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VV93_RS10315	COG1199	ATP-dependent helicase activity
VV93_RS10325	COG3923	Primosomal replication protein n
VV93_RS10335	COG0840	transmembrane signaling receptor activity
VV93_RS10340	COG0708	Exodeoxyribonuclease III
VV93_RS10380	COG1882	Formate acetyltransferase
VV93_RS10395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VV93_RS10405	COG3013	Belongs to the UPF0304 family
VV93_RS10410	COG3713	MltA-interacting MipA family protein
VV93_RS10415	COG2766	serine protein kinase
VV93_RS10420	COG2718	Belongs to the UPF0229 family
VV93_RS10425	COG2719	SpoVR family
VV93_RS10430	COG2199	diguanylate cyclase activity
VV93_RS10435	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VV93_RS10440	COG2835	tetraacyldisaccharide 4'-kinase activity
VV93_RS10445	COG1663	tetraacyldisaccharide 4'-kinase activity
VV93_RS10465	COG4591	ABC-type transport system involved in lipoprotein release permease component
VV93_RS10470	COG1136	(ABC) transporter
VV93_RS10475	COG4591	ABC-type transport system involved in lipoprotein release permease component
VV93_RS10485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VV93_RS10500	COG1252	NADH dehydrogenase
VV93_RS10530	COG0537	adenosine 5'-monophosphoramidase activity
VV93_RS10555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VV93_RS10555	COG0617	tRNA 3'-terminal CCA addition
VV93_RS10555	COG0517	IMP dehydrogenase activity
VV93_RS10560	COG3706	GGDEF domain
VV93_RS10565	COG1982	Orn Lys Arg decarboxylase major
VV93_RS10570	COG0531	amino acid
VV93_RS10575	COG3710	Transcriptional regulator
VV93_RS10595	COG2199	diguanylate cyclase activity
VV93_RS10595	COG2203	Gaf domain
VV93_RS10600	COG2239	Acts as a magnesium transporter
VV93_RS10610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VV93_RS10615	COG2226	methyltransferase
VV93_RS10630	COG1785	Belongs to the alkaline phosphatase family
VV93_RS10640	COG0346	lactoylglutathione lyase activity
VV93_RS10650	COG2983	Belongs to the UPF0260 family
VV93_RS10665	COG0745	RESPONSE REGULATOR receiver
VV93_RS10670	COG2205	protein histidine kinase activity
VV93_RS10700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VV93_RS10705	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VV93_RS10715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VV93_RS10725	COG0745	RESPONSE REGULATOR receiver
VV93_RS10730	COG0583	DNA-binding transcription factor activity
VV93_RS10735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VV93_RS10740	COG1286	toxin biosynthetic process
VV93_RS10745	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VV93_RS10750	COG0285	dihydrofolate synthase activity
VV93_RS10755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VV93_RS10760	COG0101	tRNA pseudouridine synthase activity
VV93_RS10770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VV93_RS10780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VV93_RS10785	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VV93_RS10785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV93_RS10795	COG3101	peptidyl-lysine hydroxylation
VV93_RS10800	COG2860	membrane
VV93_RS10805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VV93_RS10810	COG2890	protein-(glutamine-N5) methyltransferase activity
VV93_RS10815	COG2840	Smr protein MutS2
VV93_RS10820	COG2062	phosphohistidine phosphatase, SixA
VV93_RS10825	COG1025	Belongs to the peptidase M16 family
VV93_RS10830	COG1250	3-hydroxyacyl-CoA dehydrogenase
VV93_RS10830	COG1024	Enoyl-CoA hydratase
VV93_RS10835	COG0183	Belongs to the thiolase family
VV93_RS10850	COG2067	long-chain fatty acid transport protein
VV93_RS10860	COG2853	Lipoprotein
VV93_RS10870	COG4235	cytochrome complex assembly
VV93_RS10870	COG3088	subunit of a heme lyase
VV93_RS10875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VV93_RS10880	COG1138	Cytochrome C-type biogenesis protein
VV93_RS10885	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VV93_RS10890	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV93_RS10895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV93_RS10900	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV93_RS10905	COG4133	protoheme IX ABC transporter activity
VV93_RS10915	COG0835	chemotaxis
VV93_RS10925	COG1192	Involved in chromosome partitioning
VV93_RS10930	COG2201	protein-glutamate methylesterase activity
VV93_RS10935	COG2198	Histidine kinase
VV93_RS10935	COG0643	Histidine kinase
VV93_RS10935	COG0784	Response regulator, receiver
VV93_RS10940	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VV93_RS10975	COG1684	flagellar biosynthetic protein fliR
VV93_RS10980	COG1987	bacterial-type flagellum assembly
VV93_RS11030	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VV93_RS11040	COG1677	Flagellar hook-basal body complex protein FliE
VV93_RS11060	COG1516	flagellar protein fliS
VV93_RS11070	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VV93_RS11075	COG1334	flagellar protein FlaG
VV93_RS11080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV93_RS11085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV93_RS11090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV93_RS11095	COG2837	iron assimilation
VV93_RS11120	COG1393	Belongs to the ArsC family
VV93_RS11140	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VV93_RS11145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VV93_RS11150	COG2716	regulation of RNA biosynthetic process
VV93_RS11155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VV93_RS11180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VV93_RS11195	COG0455	bacterial-type flagellum organization
VV93_RS11205	COG3550	peptidyl-serine autophosphorylation
VV93_RS11265	COG4783	chaperone-mediated protein folding
VV93_RS11270	COG1393	Belongs to the ArsC family
VV93_RS11290	COG2233	PERMEase
VV93_RS11295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VV93_RS11300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VV93_RS11305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VV93_RS11310	COG0121	glutamine amidotransferase
VV93_RS11320	COG1960	acyl-CoA dehydrogenase activity
VV93_RS11340	COG2249	NAD(P)H dehydrogenase (quinone) activity
VV93_RS11355	COG0328	RNA-DNA hybrid ribonuclease activity
VV93_RS11360	COG2226	methyltransferase
VV93_RS11365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV93_RS11370	COG1388	LysM domain
VV93_RS11370	COG0741	lytic transglycosylase activity
VV93_RS11385	COG0347	Belongs to the P(II) protein family
VV93_RS11400	COG0825	malonyl-CoA metabolic process
VV93_RS11405	COG0587	DNA-directed DNA polymerase activity
VV93_RS11410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VV93_RS11415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV93_RS11420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV93_RS11425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VV93_RS11430	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV93_RS11435	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VV93_RS11440	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV93_RS11445	COG0750	zinc metalloprotease
VV93_RS11450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VV93_RS11455	COG0575	Belongs to the CDS family
VV93_RS11460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VV93_RS11465	COG0233	cytoplasmic translational termination
VV93_RS11470	COG0528	UMP kinase activity
VV93_RS11475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VV93_RS11480	COG0052	Belongs to the universal ribosomal protein uS2 family
VV93_RS11485	COG0024	Methionine aminopeptidase
VV93_RS11490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VV93_RS11505	COG3098	single-species biofilm formation
VV93_RS11535	COG1671	Belongs to the UPF0178 family
VV93_RS11540	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VV93_RS11545	COG0254	rRNA binding
VV93_RS11550	COG1720	tRNA m6t6A37 methyltransferase activity
VV93_RS11575	COG0733	neurotransmitter:sodium symporter activity
VV93_RS11595	COG0514	ATP-dependent DNA helicase (RecQ)
VV93_RS11600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VV93_RS11615	COG1477	protein flavinylation
VV93_RS11620	COG2871	sodium ion transport
VV93_RS11625	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV93_RS11635	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV93_RS11640	COG1805	sodium ion transport
VV93_RS11645	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV93_RS11650	COG0271	Belongs to the BolA IbaG family
VV93_RS11655	COG2813	Specifically methylates the guanine in position
VV93_RS11670	COG2211	Major facilitator Superfamily
VV93_RS11680	COG1595	DNA-templated transcription, initiation
VV93_RS11690	COG3248	Nucleoside-binding outer membrane protein
VV93_RS11695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VV93_RS11700	COG0693	protein deglycase activity
VV93_RS11705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VV93_RS11715	COG2166	iron-sulfur cluster assembly
VV93_RS11720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VV93_RS11725	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VV93_RS11745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VV93_RS11750	COG1074	ATP-dependent DNA helicase activity
VV93_RS11755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VV93_RS11760	COG3083	sulfuric ester hydrolase activity
VV93_RS11775	COG3141	response to X-ray
VV93_RS11780	COG2171	N-acyltransferase activity
VV93_RS11785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VV93_RS11790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VV93_RS11795	COG3335	DDE superfamily endonuclease
VV93_RS11805	COG1349	DNA-binding transcription factor activity
VV93_RS11810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VV93_RS11820	COG0456	acetyltransferase
VV93_RS11825	COG0569	domain protein
VV93_RS11825	COG0189	ligase activity
VV93_RS11840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV93_RS11850	COG0840	transmembrane signaling receptor activity
VV93_RS11855	COG2211	Major facilitator Superfamily
VV93_RS11865	COG1609	Transcriptional regulator
VV93_RS11870	COG2017	converts alpha-aldose to the beta-anomer
VV93_RS11885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VV93_RS11890	COG1609	Transcriptional regulator
VV93_RS11900	COG3250	beta-galactosidase activity
VV93_RS11905	COG2731	YhcH YjgK YiaL family protein
VV93_RS11910	COG0531	amino acid
VV93_RS11915	COG0531	amino acid
VV93_RS11920	COG3408	Glycogen debranching enzyme
VV93_RS11920	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
VV93_RS11930	COG0583	DNA-binding transcription factor activity
VV93_RS11935	COG2059	Chromate
VV93_RS11985	COG4964	Belongs to the GSP D family
VV93_RS12020	COG1022	Amp-dependent synthetase and ligase
VV93_RS12030	COG0583	DNA-binding transcription factor activity
VV93_RS12040	COG3335	DDE superfamily endonuclease
VV93_RS12045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VV93_RS12065	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VV93_RS12075	COG0560	Phosphoserine phosphatase
VV93_RS12085	COG0813	purine-nucleoside phosphorylase activity
VV93_RS12090	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VV93_RS12095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VV93_RS12100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VV93_RS12105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VV93_RS12110	COG0084	hydrolase, TatD family'
VV93_RS12120	COG3706	GGDEF domain
VV93_RS12130	COG0456	acetyltransferase
VV93_RS12140	COG3153	acetyltransferase
VV93_RS12145	COG3154	lipid carrier protein
VV93_RS12155	COG0826	peptidase U32
VV93_RS12160	COG0826	peptidase U32
VV93_RS12165	COG0534	Mate efflux family protein
VV93_RS12180	COG1185	polyribonucleotide nucleotidyltransferase activity
VV93_RS12205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VV93_RS12210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VV93_RS12215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VV93_RS12225	COG0195	Participates in both transcription termination and antitermination
VV93_RS12230	COG0779	Required for maturation of 30S ribosomal subunits
VV93_RS12245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VV93_RS12250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV93_RS12255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VV93_RS12260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VV93_RS12265	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VV93_RS12270	COG1534	Rna-binding protein
VV93_RS12290	COG2027	D-alanyl-D-alanine carboxypeptidase
VV93_RS12295	COG2832	Protein of unknown function (DUF454)
VV93_RS12300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VV93_RS12305	COG0739	heme binding
VV93_RS12330	COG0628	permease
VV93_RS12335	COG2813	Specifically methylates the guanine in position
VV93_RS12340	COG0784	Response regulator, receiver
VV93_RS12340	COG2205	protein histidine kinase activity
VV93_RS12350	COG0601	transmembrane transport
VV93_RS12355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV93_RS12360	COG0444	Belongs to the ABC transporter superfamily
VV93_RS12365	COG4608	Belongs to the ABC transporter superfamily
VV93_RS12375	COG2971	BadF BadG BcrA BcrD
VV93_RS12390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV93_RS12405	COG1840	ABC-type Fe3 transport system, periplasmic component
VV93_RS12410	COG0004	ammonium transporteR
VV93_RS12415	COG0347	Belongs to the P(II) protein family
VV93_RS12420	COG3112	Uncharacterised protein family (UPF0231)
VV93_RS12425	COG3835	regulator
VV93_RS12430	COG2610	gluconate transmembrane transporter activity
VV93_RS12435	COG1929	Belongs to the glycerate kinase type-1 family
VV93_RS12440	COG1049	propionate catabolic process, 2-methylcitrate cycle
VV93_RS12445	COG1752	Esterase of the alpha-beta hydrolase superfamily
VV93_RS12450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VV93_RS12455	COG1643	Atp-dependent helicase
VV93_RS12460	COG1489	DNA binding
VV93_RS12465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VV93_RS12470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV93_RS12480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VV93_RS12485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VV93_RS12495	COG0842	Transport permease protein
VV93_RS12500	COG1131	(ABC) transporter
VV93_RS12505	COG0659	secondary active sulfate transmembrane transporter activity
VV93_RS12510	COG0288	reversible hydration of carbon dioxide
VV93_RS12525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV93_RS12530	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV93_RS12535	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VV93_RS12540	COG2186	Transcriptional regulator
VV93_RS12545	COG3023	N-Acetylmuramoyl-L-alanine amidase
VV93_RS12560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV93_RS12565	COG1459	type II secretion system
VV93_RS12590	COG0335	large ribosomal subunit rRNA binding
VV93_RS12595	COG0336	Belongs to the RNA methyltransferase TrmD family
VV93_RS12600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VV93_RS12605	COG0228	four-way junction DNA binding
VV93_RS12610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VV93_RS12615	COG4137	Cytochrome C assembly protein
VV93_RS12620	COG4536	flavin adenine dinucleotide binding
VV93_RS12625	COG1854	S-ribosylhomocysteine lyase activity
VV93_RS12635	COG2918	glutathione biosynthetic process
VV93_RS12640	COG0612	Peptidase, M16
VV93_RS12645	COG1238	metal cluster binding
VV93_RS12655	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VV93_RS12660	COG0511	ligase activity, forming carbon-carbon bonds
VV93_RS12660	COG5016	pyruvate
VV93_RS12665	COG3630	sodium ion export across plasma membrane
VV93_RS12710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VV93_RS12715	COG0527	aspartate kinase activity
VV93_RS12730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VV93_RS12740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VV93_RS12745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VV93_RS12750	COG4942	peptidase
VV93_RS12750	COG1388	LysM domain
VV93_RS12755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VV93_RS12765	COG0585	pseudouridine synthase activity
VV93_RS12770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VV93_RS12780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VV93_RS12790	COG0504	CTP synthase activity
VV93_RS12795	COG3956	TIGRFAM MazG family protein
VV93_RS12800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV93_RS12805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VV93_RS12810	COG4999	Histidine kinase
VV93_RS12810	COG2205	protein histidine kinase activity
VV93_RS12810	COG3437	response regulator, receiver
VV93_RS12810	COG3850	Histidine kinase
VV93_RS12835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VV93_RS12840	COG1381	Involved in DNA repair and RecF pathway recombination
VV93_RS12845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VV93_RS12860	COG0481	GTPase activity
VV93_RS12865	COG3086	response to oxidative stress
VV93_RS12880	COG1595	DNA-templated transcription, initiation
VV93_RS12885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VV93_RS12915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV93_RS12920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV93_RS12925	COG3079	Belongs to the UPF0149 family
VV93_RS12930	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VV93_RS12935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VV93_RS12945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VV93_RS12960	COG1279	arginine transmembrane transporter activity
VV93_RS12965	COG0668	transmembrane transport
VV93_RS12970	COG0191	fructose-bisphosphate aldolase activity
VV93_RS12975	COG0126	phosphoglycerate kinase activity
VV93_RS12995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VV93_RS13010	COG2356	endonuclease I
VV93_RS13020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VV93_RS13030	COG1678	Uncharacterized ACR, COG1678
VV93_RS13035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VV93_RS13050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VV93_RS13055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VV93_RS13060	COG0762	integral membrane protein
VV93_RS13065	COG1872	DUF167
VV93_RS13075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VV93_RS13080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VV93_RS13090	COG2066	Belongs to the glutaminase family
VV93_RS13095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VV93_RS13105	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VV93_RS13110	COG0741	lytic transglycosylase activity
VV93_RS13180	COG3335	DDE superfamily endonuclease
VV93_RS13215	COG3437	response regulator, receiver
VV93_RS13225	COG1609	Transcriptional regulator
VV93_RS13235	COG1486	melibiose metabolic process
VV93_RS13240	COG1447	Phosphotransferase system cellobiose-specific component IIA
VV93_RS13250	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VV93_RS13255	COG0726	polysaccharide deacetylase
VV93_RS13350	COG0795	lipopolysaccharide-transporting ATPase activity
VV93_RS13355	COG0795	lipopolysaccharide-transporting ATPase activity
VV93_RS13360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VV93_RS13365	COG3385	transposase activity
VV93_RS13370	COG2927	DNA polymerase III (CHI subunit)
VV93_RS13375	COG0525	valine-tRNA ligase activity
VV93_RS13385	COG4269	membrane
VV93_RS13395	COG0456	acetyltransferase
VV93_RS13410	COG2235	arginine
VV93_RS13425	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VV93_RS13430	COG0251	oxidation-reduction process
VV93_RS13435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV93_RS13450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VV93_RS13455	COG0312	modulator of DNA gyrase
VV93_RS13460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VV93_RS13465	COG3164	Protein of unknown function
VV93_RS13475	COG0424	maF-like protein
VV93_RS13480	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VV93_RS13485	COG1792	Involved in formation and maintenance of cell shape
VV93_RS13490	COG1077	Cell shape determining protein MreB Mrl
VV93_RS13520	COG2165	general secretion pathway protein
VV93_RS13525	COG2165	general secretion pathway protein
VV93_RS13535	COG1459	type II secretion system
VV93_RS13540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV93_RS13550	COG3409	Peptidoglycan-binding domain 1 protein
VV93_RS13550	COG3267	Type II secretory pathway component ExeA
VV93_RS13575	COG2200	EAL domain
VV93_RS13575	COG2199	diguanylate cyclase activity
VV93_RS13595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VV93_RS13605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VV93_RS13610	COG0527	aspartate kinase activity
VV93_RS13615	COG0646	methionine synthase
VV93_RS13615	COG1410	methionine synthase
VV93_RS13640	COG3335	DDE superfamily endonuclease
VV93_RS13650	COG3335	DDE superfamily endonuclease
VV93_RS13660	COG3335	DDE superfamily endonuclease
VV93_RS13695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VV93_RS13725	COG0735	belongs to the Fur family
VV93_RS13740	COG0432	Pfam Uncharacterised protein family UPF0047
VV93_RS13750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VV93_RS13765	COG0359	binds to the 23S rRNA
VV93_RS13775	COG2965	DNA replication, synthesis of RNA primer
VV93_RS13780	COG0360	Binds together with S18 to 16S ribosomal RNA
VV93_RS13785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VV93_RS13790	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VV93_RS13800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VV93_RS13805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VV93_RS13835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VV93_RS13850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VV93_RS13850	COG0165	Argininosuccinate lyase
VV93_RS13855	COG0137	argininosuccinate synthase activity
VV93_RS13870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VV93_RS13875	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VV93_RS13885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VV93_RS13890	COG0460	homoserine dehydrogenase
VV93_RS13890	COG0527	aspartate kinase activity
VV93_RS13895	COG0626	cystathionine gamma-synthase activity
VV93_RS13900	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VV93_RS13905	COG0281	malic enzyme
VV93_RS13910	COG0254	rRNA binding
VV93_RS13915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VV93_RS13920	COG1609	Transcriptional regulator
VV93_RS13930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VV93_RS13935	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VV93_RS13940	COG1575	Belongs to the MenA family. Type 1 subfamily
VV93_RS13950	COG3074	FtsZ-dependent cytokinesis
VV93_RS13955	COG1494	fructose-1,6-bisphosphatase
VV93_RS13980	COG0149	triose-phosphate isomerase activity
VV93_RS13985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VV93_RS13995	COG2906	2 iron, 2 sulfur cluster binding
VV93_RS14005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VV93_RS14010	COG0049	tRNA binding
VV93_RS14015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VV93_RS14035	COG2964	Protein conserved in bacteria
VV93_RS14040	COG0545	Peptidyl-prolyl cis-trans isomerase
VV93_RS14050	COG2900	Belongs to the SlyX family
VV93_RS14060	COG1047	Peptidyl-prolyl cis-trans
VV93_RS14075	COG2249	NAD(P)H dehydrogenase (quinone) activity
VV93_RS14080	COG0488	(ABC) transporter
VV93_RS14090	COG0429	hydrolase of the alpha beta-hydrolase fold
VV93_RS14095	COG3089	Belongs to the UPF0270 family
VV93_RS14100	COG3954	Phosphoribulokinase
VV93_RS14105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV93_RS14115	COG1012	belongs to the aldehyde dehydrogenase family
VV93_RS14125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VV93_RS14155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV93_RS14160	COG0557	exoribonuclease II activity
VV93_RS14165	COG0402	S-adenosylhomocysteine deaminase activity
VV93_RS14170	COG1959	2 iron, 2 sulfur cluster binding
VV93_RS14175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VV93_RS14175	COG1017	nitric oxide dioxygenase activity
VV93_RS14180	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VV93_RS14185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VV93_RS14190	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VV93_RS14195	COG0330	HflC and HflK could
VV93_RS14200	COG0330	HflC and HflK could
VV93_RS14205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VV93_RS14210	COG1923	regulation of RNA biosynthetic process
VV93_RS14225	COG0860	N-Acetylmuramoyl-L-alanine amidase
VV93_RS14230	COG0802	atpase or kinase
VV93_RS14235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VV93_RS14295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VV93_RS14300	COG1162	GTPase activity
VV93_RS14305	COG0688	phosphatidylethanolamine metabolic process
VV93_RS14310	COG0471	metal ion transport
VV93_RS14320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VV93_RS14330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV93_RS14335	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VV93_RS14340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VV93_RS14345	COG1045	serine acetyltransferase
VV93_RS14350	COG4942	peptidase
VV93_RS14370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VV93_RS14375	COG1053	succinate dehydrogenase
VV93_RS14380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VV93_RS14385	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VV93_RS14390	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VV93_RS14400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VV93_RS14405	COG1509	lysine 2,3-aminomutase activity
VV93_RS14410	COG1285	pathogenesis
VV93_RS14420	COG0459	protein refolding
VV93_RS14425	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VV93_RS14430	COG0534	Mate efflux family protein
VV93_RS14435	COG0205	6-phosphofructokinase activity
VV93_RS14445	COG3678	ATP-independent chaperone mediated protein folding
VV93_RS14450	COG0745	RESPONSE REGULATOR receiver
VV93_RS14455	COG2205	protein histidine kinase activity
VV93_RS14465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VV93_RS14475	COG1027	Aspartate ammonia-lyase
VV93_RS14480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VV93_RS14485	COG4232	protein-disulfide reductase activity
VV93_RS14495	COG2095	MarC family integral membrane protein
VV93_RS14505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VV93_RS14510	COG2198	Histidine kinase
VV93_RS14510	COG0784	Response regulator, receiver
VV93_RS14510	COG2205	protein histidine kinase activity
VV93_RS14515	COG2814	Major facilitator Superfamily
VV93_RS14530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VV93_RS14535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VV93_RS14540	COG0511	ligase activity, forming carbon-carbon bonds
VV93_RS14545	COG0439	Biotin carboxylase
VV93_RS14560	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VV93_RS14565	COG0840	transmembrane signaling receptor activity
VV93_RS14570	COG0789	Transcriptional regulator
VV93_RS14575	COG0138	bifunctional purine biosynthesis protein purh
VV93_RS14580	COG0151	Belongs to the GarS family
VV93_RS14585	COG3335	DDE superfamily endonuclease
VV93_RS14605	COG1253	flavin adenine dinucleotide binding
VV93_RS14610	COG3068	Protein conserved in bacteria
VV93_RS14615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV93_RS14620	COG1573	uracil-dna glycosylase
VV93_RS14625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VV93_RS14645	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VV93_RS14650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VV93_RS14655	COG0085	RNA polymerase activity
VV93_RS14660	COG0222	ribosome binding
VV93_RS14665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VV93_RS14670	COG0081	regulation of translation
VV93_RS14675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VV93_RS14685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VV93_RS14690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VV93_RS14725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VV93_RS14735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VV93_RS14745	COG3335	DDE superfamily endonuclease
VV93_RS14755	COG3335	DDE superfamily endonuclease
VV93_RS14765	COG3335	DDE superfamily endonuclease
VV93_RS14825	COG3118	belongs to the thioredoxin family
VV93_RS14835	COG0248	Ppx GppA phosphatase
VV93_RS14840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VV93_RS14850	COG0514	ATP-dependent DNA helicase (RecQ)
VV93_RS14855	COG2962	Rard protein
VV93_RS14865	COG1280	lysine exporter protein (LysE YggA)
VV93_RS14870	COG0210	DNA helicase
VV93_RS14880	COG3220	belongs to the UPF0276 family
VV93_RS14905	COG0006	proline dipeptidase activity
VV93_RS14905	COG0006	proline dipeptidase activity
VV93_RS14915	COG2022	thiamine diphosphate biosynthetic process
VV93_RS14925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VV93_RS14935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VV93_RS14940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VV93_RS14945	COG2132	Multicopper oxidase
VV93_RS14965	COG3335	DDE superfamily endonuclease
VV93_RS14975	COG3335	DDE superfamily endonuclease
VV93_RS15015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VV93_RS15025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VV93_RS15030	COG0408	coproporphyrinogen oxidase activity
VV93_RS15035	COG0009	L-threonylcarbamoyladenylate synthase
VV93_RS15040	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VV93_RS15050	COG0551	DNA topoisomerase type I activity
VV93_RS15055	COG2922	Belongs to the Smg family
VV93_RS15060	COG0758	DNA mediated transformation
VV93_RS15070	COG0242	peptide deformylase activity
VV93_RS15075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VV93_RS15080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VV93_RS15080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VV93_RS15085	COG0569	domain protein
VV93_RS15090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV93_RS15095	COG1272	protein, Hemolysin III
VV93_RS15100	COG4326	sporulation control protein
VV93_RS15105	COG3084	Protein conserved in bacteria
VV93_RS15115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VV93_RS15120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VV93_RS15125	COG0204	Acyl-transferase
VV93_RS15135	COG0606	chelatase, subunit chli
VV93_RS15145	COG3978	acetolactate synthase activity
VV93_RS15150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VV93_RS15155	COG0129	dihydroxy-acid dehydratase activity
VV93_RS15165	COG0583	DNA-binding transcription factor activity
VV93_RS15170	COG2814	Major facilitator Superfamily
VV93_RS15180	COG0765	amino acid transport
VV93_RS15185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VV93_RS15190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VV93_RS15195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VV93_RS15200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VV93_RS15205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VV93_RS15210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VV93_RS15215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VV93_RS15225	COG0356	it plays a direct role in the translocation of protons across the membrane
VV93_RS15230	COG3312	ion transport
VV93_RS15235	COG1475	DNA binding
VV93_RS15240	COG1192	Involved in chromosome partitioning
VV93_RS15245	COG0357	Ribosomal RNA small subunit methyltransferase G
VV93_RS15250	COG0445	tRNA wobble uridine modification
VV93_RS15260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VV93_RS15350	COG4974	Belongs to the 'phage' integrase family
VV93_RS15360	COG0706	membrane insertase activity
VV93_RS15365	COG0594	ribonuclease P activity
VV93_RS15370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VV93_RS15375	COG1126	abc transporter atp-binding protein
VV93_RS15570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VV93_RS15580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV93_RS15735	COG0697	spore germination
VV93_RS16170	COG5001	Diguanylate cyclase
VV93_RS16170	COG3300	MHYT domain
VV93_RS16365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV93_RS16460	COG1566	PFAM secretion protein HlyD family protein
VV93_RS16635	COG1560	Kdo2-lipid A biosynthetic process
VV93_RS16925	COG3064	Membrane
VV93_RS16955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VV93_RS17045	COG3273	potassium ion transport
VV93_RS17045	COG0471	metal ion transport
VV93_RS17090	COG2911	Protein conserved in bacteria
VV93_RS17120	COG1178	ABC-type Fe3 transport system permease component
VV93_RS17260	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VV93_RS17280	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VV93_RS17380	COG3706	GGDEF domain
VV93_RS17635	COG3409	Peptidoglycan-binding domain 1 protein
VV93_RS17635	COG3267	Type II secretory pathway component ExeA
VV93_RS17680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VV93_RS17710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VV93_RS17815	COG0275	rRNA processing
VV93_RS17830	COG0768	penicillin binding
VV93_RS17865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VV93_RS17905	COG0653	protein targeting
VV93_RS17920	COG0505	Belongs to the CarA family
VV93_RS17925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VV93_RS17985	COG0070	glutamate synthase
VV93_RS17985	COG0069	glutamate synthase activity
VV93_RS17985	COG0067	glutamate synthase
VV93_RS18010	COG0070	glutamate synthase
VV93_RS18010	COG0069	glutamate synthase activity
VV93_RS18010	COG0067	glutamate synthase
VV93_RS18355	COG0542	response to heat
VV93_RS18945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VV93_RS18945	COG0047	phosphoribosylformylglycinamidine synthase activity
VV93_RS19005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VV93_RS19250	COG0495	leucyl-tRNA aminoacylation
VV93_RS19340	COG0012	GTP binding
VV93_RS19445	COG2608	mercury ion transmembrane transporter activity
VV93_RS19445	COG2217	Heavy metal translocating P-type atpase
VV93_RS19525	COG4786	Flagellar basal body rod
VV93_RS19720	COG2190	(PTS) system
VV93_RS19720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV93_RS19720	COG1263	PTS System
VV93_RS19730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV93_RS19865	COG1199	ATP-dependent helicase activity
VV93_RS19970	COG2986	histidine ammonia-lyase
VV93_RS20090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VV93_RS20245	COG5001	Diguanylate cyclase
VV93_RS20335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VV93_RS20535	COG0521	Mo-molybdopterin cofactor biosynthetic process
VV93_RS20670	COG0417	DNA replication proofreading
VV93_RS20710	COG0076	glutamate decarboxylase activity
VV93_RS20735	COG1058	Belongs to the CinA family
VV93_RS20735	COG1546	Belongs to the CinA family
VV93_RS20850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV93_RS20850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV93_RS20855	COG0489	protein tyrosine kinase activity
VV93_RS21020	COG0587	DNA-directed DNA polymerase activity
VV93_RS21040	COG0616	signal peptide processing
VV93_RS21050	COG0539	negative regulation of cytoplasmic translation
VV93_RS21095	COG4166	transmembrane transport
VV93_RS21430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV93_RS21975	COG1653	transport
VV93_RS22600	COG0116	Belongs to the methyltransferase superfamily
VV93_RS22600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VV93_RS23060	COG1040	competence protein
VV93_RS23065	COG0438	transferase activity, transferring glycosyl groups
VV93_RS23090	COG2165	general secretion pathway protein