locus-tag	class	description
AL549_RS00035	COG0633	Ferredoxin
AL549_RS00035	COG3217	Mosc domain protein beta barrel domain protein
AL549_RS00035	COG0633	Ferredoxin
AL549_RS00035	COG3217	Mosc domain protein beta barrel domain protein
AL549_RS00040	COG0418	dihydroorotase activity
AL549_RS00050	COG2354	Protein conserved in bacteria
AL549_RS00080	COG3833	ABC-type maltose transport systems, permease component
AL549_RS00085	COG1175	transmembrane transport
AL549_RS00100	COG3842	ATPase activity
AL549_RS00105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL549_RS00115	COG1596	polysaccharide export
AL549_RS00120	COG3206	protein involved in exopolysaccharide biosynthesis
AL549_RS00120	COG0489	protein tyrosine kinase activity
AL549_RS00185	COG0714	Associated with various cellular activities
AL549_RS00205	COG2304	oxidoreductase activity
AL549_RS00215	COG3706	GGDEF domain
AL549_RS00215	COG2203	Gaf domain
AL549_RS00215	COG4251	negative regulation of phosphorylation
AL549_RS00215	COG5001	Diguanylate cyclase
AL549_RS00220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL549_RS00225	COG0581	inorganic phosphate transmembrane transporter activity
AL549_RS00230	COG0573	inorganic phosphate transmembrane transporter activity
AL549_RS00275	COG0513	Belongs to the DEAD box helicase family
AL549_RS00285	COG1388	LysM domain
AL549_RS00285	COG1376	ErfK ybiS ycfS ynhG family protein
AL549_RS00290	COG0415	Belongs to the DNA photolyase family
AL549_RS00295	COG0789	Transcriptional regulator
AL549_RS00300	COG3272	Protein of unknown function (DUF1722)
AL549_RS00305	COG0813	purine-nucleoside phosphorylase activity
AL549_RS00330	COG1566	PFAM secretion protein HlyD family protein
AL549_RS00335	COG4720	Psort location CytoplasmicMembrane, score
AL549_RS00355	COG0793	Belongs to the peptidase S41A family
AL549_RS00355	COG4946	Tricorn protease homolog
AL549_RS00360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL549_RS00385	COG0668	transmembrane transport
AL549_RS00415	COG2274	protein secretion by the type I secretion system
AL549_RS00425	COG3111	PFAM Bacterial OB fold (BOF) protein
AL549_RS00430	COG0784	Response regulator, receiver
AL549_RS00430	COG2205	protein histidine kinase activity
AL549_RS00450	COG2197	response regulator
AL549_RS00460	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AL549_RS00490	COG3040	lipid binding
AL549_RS00555	COG3240	lipase activity
AL549_RS00570	COG2211	Major facilitator Superfamily
AL549_RS00580	COG0346	lactoylglutathione lyase activity
AL549_RS00600	COG0753	catalase activity
AL549_RS00620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL549_RS00630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL549_RS00645	COG0393	Putative heavy-metal-binding
AL549_RS00665	COG4771	TonB-dependent receptor
AL549_RS00670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL549_RS00675	COG0039	L-malate dehydrogenase activity
AL549_RS00695	COG2814	Major facilitator Superfamily
AL549_RS00770	COG0351	phosphomethylpyrimidine kinase
AL549_RS00775	COG0671	phosphoesterase, PA-phosphatase related
AL549_RS00790	COG0561	phosphatase activity
AL549_RS00800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL549_RS00805	COG0076	glutamate decarboxylase activity
AL549_RS00810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL549_RS00835	COG4221	oxidoreductase activity
AL549_RS00855	COG0745	RESPONSE REGULATOR receiver
AL549_RS00860	COG2205	protein histidine kinase activity
AL549_RS00865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL549_RS00870	COG2194	sulfuric ester hydrolase activity
AL549_RS00875	COG1368	sulfuric ester hydrolase activity
AL549_RS00890	COG2356	endonuclease I
AL549_RS00905	COG3706	GGDEF domain
AL549_RS00915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL549_RS00950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL549_RS00995	COG1301	dicarboxylic acid transport
AL549_RS01005	COG0137	argininosuccinate synthase activity
AL549_RS01025	COG1733	regulation of RNA biosynthetic process
AL549_RS01030	COG0583	DNA-binding transcription factor activity
AL549_RS01090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL549_RS01095	COG0583	DNA-binding transcription factor activity
AL549_RS01105	COG3383	formate dehydrogenase (NAD+) activity
AL549_RS01125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL549_RS01135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL549_RS01145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL549_RS01150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL549_RS01160	COG2207	Transcriptional regulator
AL549_RS01165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL549_RS01165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL549_RS01165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL549_RS01170	COG1482	cell wall glycoprotein biosynthetic process
AL549_RS01230	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AL549_RS01235	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL549_RS01240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL549_RS01250	COG2211	Major facilitator Superfamily
AL549_RS01275	COG1129	ABC transporter
AL549_RS01285	COG1609	Transcriptional regulator
AL549_RS01310	COG0564	pseudouridine synthase activity
AL549_RS01345	COG1566	PFAM secretion protein HlyD family protein
AL549_RS01355	COG0534	Mate efflux family protein
AL549_RS01360	COG1472	Belongs to the glycosyl hydrolase 3 family
AL549_RS01375	COG4580	involved in the transport of maltose and maltodextrins
AL549_RS01390	COG1609	Transcriptional regulator
AL549_RS01400	COG4608	Belongs to the ABC transporter superfamily
AL549_RS01405	COG0444	Belongs to the ABC transporter superfamily
AL549_RS01410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL549_RS01420	COG0747	negative chemotaxis
AL549_RS01430	COG1609	Transcriptional regulator
AL549_RS01435	COG3842	ATPase activity
AL549_RS01445	COG0395	ABC-type sugar transport system, permease component
AL549_RS01460	COG1609	Transcriptional regulator
AL549_RS01480	COG2199	diguanylate cyclase activity
AL549_RS01490	COG0642	Histidine kinase
AL549_RS01500	COG0583	DNA-binding transcription factor activity
AL549_RS01510	COG0612	Peptidase, M16
AL549_RS01515	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL549_RS01520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL549_RS01525	COG0625	glutathione transferase activity
AL549_RS01530	COG1012	belongs to the aldehyde dehydrogenase family
AL549_RS01585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL549_RS01590	COG0840	transmembrane signaling receptor activity
AL549_RS01600	COG1640	4-alpha-glucanotransferase
AL549_RS01605	COG0058	SHG alpha-glucan phosphorylase activity
AL549_RS01610	COG2909	trisaccharide binding
AL549_RS01625	COG1999	signal sequence binding
AL549_RS01630	COG2847	Copper chaperone PCu(A)C
AL549_RS01635	COG1162	GTPase activity
AL549_RS01640	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL549_RS01650	COG0531	amino acid
AL549_RS01655	COG1982	Orn Lys Arg decarboxylase major
AL549_RS01710	COG3706	GGDEF domain
AL549_RS01715	COG5001	Diguanylate cyclase
AL549_RS01725	COG1741	Belongs to the pirin family
AL549_RS01730	COG3123	guanosine phosphorylase activity
AL549_RS01750	COG1309	transcriptional regulator
AL549_RS01775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL549_RS01780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL549_RS01785	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL549_RS01805	COG0189	ligase activity
AL549_RS01820	COG0363	glucosamine-6-phosphate deaminase activity
AL549_RS01830	COG0786	glutamate:sodium symporter activity
AL549_RS01835	COG0786	glutamate:sodium symporter activity
AL549_RS01860	COG3275	phosphorelay sensor kinase activity
AL549_RS01875	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL549_RS01880	COG1136	(ABC) transporter
AL549_RS01890	COG0583	DNA-binding transcription factor activity
AL549_RS01900	COG0217	transcriptional regulatory protein
AL549_RS01920	COG3385	transposase activity
AL549_RS01925	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AL549_RS01925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL549_RS01935	COG0444	Belongs to the ABC transporter superfamily
AL549_RS01940	COG4608	Belongs to the ABC transporter superfamily
AL549_RS01965	COG1444	tRNA N-acetyltransferase activity
AL549_RS01975	COG0745	RESPONSE REGULATOR receiver
AL549_RS01990	COG0835	chemotaxis
AL549_RS01995	COG0840	transmembrane signaling receptor activity
AL549_RS02000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL549_RS02005	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AL549_RS02010	COG2201	protein-glutamate methylesterase activity
AL549_RS02015	COG0840	transmembrane signaling receptor activity
AL549_RS02060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL549_RS02065	COG0583	DNA-binding transcription factor activity
AL549_RS02075	COG0406	alpha-ribazole phosphatase activity
AL549_RS02080	COG2200	EAL domain
AL549_RS02080	COG2199	diguanylate cyclase activity
AL549_RS02080	COG2203	Gaf domain
AL549_RS02090	COG1263	PTS System
AL549_RS02090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL549_RS02095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL549_RS02105	COG1737	Transcriptional regulator
AL549_RS02110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL549_RS02110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL549_RS02120	COG0110	maltose O-acetyltransferase activity
AL549_RS02125	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL549_RS02130	COG0459	protein refolding
AL549_RS02165	COG2204	response regulator
AL549_RS02175	COG0259	pyridoxamine-phosphate oxidase activity
AL549_RS02200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL549_RS02220	COG5492	domain, Protein
AL549_RS02225	COG3119	arylsulfatase activity
AL549_RS02230	COG3119	arylsulfatase activity
AL549_RS02235	COG0641	radical SAM
AL549_RS02240	COG3119	arylsulfatase activity
AL549_RS02250	COG0747	negative chemotaxis
AL549_RS02260	COG0601	transmembrane transport
AL549_RS02265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL549_RS02290	COG0659	secondary active sulfate transmembrane transporter activity
AL549_RS02295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL549_RS02305	COG1028	Short-chain dehydrogenase reductase Sdr
AL549_RS02315	COG5426	von Willebrand factor, type A
AL549_RS02320	COG5492	domain, Protein
AL549_RS02325	COG1132	(ABC) transporter
AL549_RS02340	COG3623	hexulose-6-phosphate isomerase
AL549_RS02345	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AL549_RS02350	COG0561	phosphatase activity
AL549_RS02380	COG1902	pentaerythritol trinitrate reductase activity
AL549_RS02385	COG2999	glutathione oxidoreductase activity
AL549_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
AL549_RS02405	COG0800	Aldolase
AL549_RS02410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL549_RS02415	COG1904	glucuronate isomerase
AL549_RS02420	COG0246	Mannitol dehydrogenase
AL549_RS02430	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL549_RS02440	COG2186	Transcriptional regulator
AL549_RS02450	COG0513	Belongs to the DEAD box helicase family
AL549_RS02455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL549_RS02460	COG1757	Na H antiporter
AL549_RS02470	COG1335	isochorismatase
AL549_RS02480	COG0697	spore germination
AL549_RS02490	COG2258	MOSC domain
AL549_RS02510	COG1486	melibiose metabolic process
AL549_RS02515	COG0583	DNA-binding transcription factor activity
AL549_RS02535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL549_RS02550	COG0840	transmembrane signaling receptor activity
AL549_RS02570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL549_RS02575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL549_RS02600	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL549_RS02615	COG2207	Transcriptional regulator
AL549_RS02620	COG0697	spore germination
AL549_RS02625	COG1349	DNA-binding transcription factor activity
AL549_RS02635	COG1349	DNA-binding transcription factor activity
AL549_RS02645	COG2222	sugar isomerase
AL549_RS02650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL549_RS02660	COG3716	PTS system mannose fructose sorbose family IID component
AL549_RS02665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL549_RS02680	COG0488	(ABC) transporter
AL549_RS02700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL549_RS02705	COG1120	ATPase activity
AL549_RS02735	COG1136	(ABC) transporter
AL549_RS02735	COG0577	efflux transmembrane transporter activity
AL549_RS02740	COG0577	efflux transmembrane transporter activity
AL549_RS02740	COG1136	(ABC) transporter
AL549_RS02745	COG2176	DNA-directed DNA polymerase activity
AL549_RS02765	COG3706	GGDEF domain
AL549_RS02800	COG2205	protein histidine kinase activity
AL549_RS02815	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL549_RS02845	COG0579	oxidoreductase
AL549_RS02855	COG3437	response regulator, receiver
AL549_RS02875	COG1357	PFAM Pentapeptide repeats (8 copies)
AL549_RS02885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL549_RS02920	COG0513	Belongs to the DEAD box helicase family
AL549_RS02940	COG0583	DNA-binding transcription factor activity
AL549_RS02950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL549_RS02980	COG2814	Major facilitator Superfamily
AL549_RS03000	COG0583	DNA-binding transcription factor activity
AL549_RS03020	COG1858	cytochrome C peroxidase
AL549_RS03045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL549_RS03055	COG0454	-acetyltransferase
AL549_RS03075	COG2205	protein histidine kinase activity
AL549_RS03100	COG3046	protein related to deoxyribodipyrimidine photolyase
AL549_RS03105	COG2207	Transcriptional regulator
AL549_RS03110	COG1881	PFAM PEBP family protein
AL549_RS03115	COG0494	nUDIX hydrolase
AL549_RS03150	COG0668	transmembrane transport
AL549_RS03170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL549_RS03170	COG3153	acetyltransferase
AL549_RS03200	COG1028	Short-chain dehydrogenase reductase Sdr
AL549_RS03210	COG1917	Cupin 2, conserved barrel domain protein
AL549_RS03230	COG0697	spore germination
AL549_RS03235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL549_RS03240	COG0800	Aldolase
AL549_RS03270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL549_RS03275	COG0823	Involved in the tonB-independent uptake of proteins
AL549_RS03280	COG0366	Alpha amylase catalytic
AL549_RS03290	COG3366	ferrous iron transmembrane transporter activity
AL549_RS03295	COG0700	Nucleoside recognition
AL549_RS03300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL549_RS03335	COG0640	Transcriptional regulator
AL549_RS03340	COG0798	PFAM Bile acid sodium symporter
AL549_RS03360	COG2194	sulfuric ester hydrolase activity
AL549_RS03365	COG0583	DNA-binding transcription factor activity
AL549_RS03375	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL549_RS03400	COG0673	inositol 2-dehydrogenase activity
AL549_RS03405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL549_RS03410	COG2197	response regulator
AL549_RS03415	COG0384	phenazine biosynthesis protein PhzF
AL549_RS03430	COG1879	ABC-type sugar transport system periplasmic component
AL549_RS03440	COG3284	Transcriptional regulator
AL549_RS03445	COG1012	belongs to the aldehyde dehydrogenase family
AL549_RS03455	COG1253	flavin adenine dinucleotide binding
AL549_RS03480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL549_RS03485	COG1609	Transcriptional regulator
AL549_RS03505	COG0488	(ABC) transporter
AL549_RS03510	COG0814	amino acid
AL549_RS03515	COG3033	Beta-eliminating lyase
AL549_RS03530	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL549_RS03555	COG0189	ligase activity
AL549_RS03555	COG4067	protein conserved in archaea
AL549_RS03560	COG0189	ligase activity
AL549_RS03575	COG4774	siderophore transport
AL549_RS03575	COG1629	transport
AL549_RS03580	COG4607	ABC-type enterochelin transport system periplasmic component
AL549_RS03590	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL549_RS03610	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL549_RS03615	COG1169	isochorismate synthase
AL549_RS03620	COG1028	Short-chain dehydrogenase reductase Sdr
AL549_RS03625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL549_RS03640	COG2977	Belongs to the P-Pant transferase superfamily
AL549_RS03655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL549_RS03660	COG0840	transmembrane signaling receptor activity
AL549_RS03670	COG2755	lipolytic protein G-D-S-L family
AL549_RS03675	COG5002	protein histidine kinase activity
AL549_RS03675	COG5001	Diguanylate cyclase
AL549_RS03690	COG4160	amino acid transport
AL549_RS03695	COG4215	(ABC) transporter
AL549_RS03700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL549_RS03705	COG1126	abc transporter atp-binding protein
AL549_RS03710	COG3015	lipoprotein NlpE involved in copper resistance
AL549_RS03725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL549_RS03765	COG2814	Major facilitator Superfamily
AL549_RS03790	COG1139	Iron-sulfur cluster binding protein
AL549_RS03800	COG1620	l-lactate permease
AL549_RS03805	COG0583	DNA-binding transcription factor activity
AL549_RS03810	COG1505	serine-type exopeptidase activity
AL549_RS03815	COG4172	Belongs to the ABC transporter superfamily
AL549_RS03825	COG1067	ATP-dependent peptidase activity
AL549_RS03830	COG0402	S-adenosylhomocysteine deaminase activity
AL549_RS03835	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AL549_RS03845	COG2239	Acts as a magnesium transporter
AL549_RS03870	COG0745	RESPONSE REGULATOR receiver
AL549_RS03875	COG2205	protein histidine kinase activity
AL549_RS03890	COG0121	glutamine amidotransferase
AL549_RS03895	COG0531	amino acid
AL549_RS03905	COG1522	sequence-specific DNA binding
AL549_RS03925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL549_RS03930	COG0583	DNA-binding transcription factor activity
AL549_RS03955	COG2205	protein histidine kinase activity
AL549_RS03955	COG5002	protein histidine kinase activity
AL549_RS03955	COG0784	Response regulator, receiver
AL549_RS03960	COG0534	Mate efflux family protein
AL549_RS03965	COG2926	Belongs to the UPF0265 family
AL549_RS03980	COG2827	Endonuclease containing a URI domain
AL549_RS03990	COG1879	ABC-type sugar transport system periplasmic component
AL549_RS04040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL549_RS04045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL549_RS04055	COG0183	Belongs to the thiolase family
AL549_RS04075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL549_RS04080	COG1940	carbohydrate kinase activity
AL549_RS04085	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AL549_RS04090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL549_RS04095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL549_RS04100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL549_RS04105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL549_RS04110	COG1737	Transcriptional regulator
AL549_RS04115	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AL549_RS04120	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AL549_RS04130	COG3005	denitrification pathway
AL549_RS04140	COG0243	molybdopterin cofactor binding
AL549_RS04150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL549_RS04155	COG3850	Histidine kinase
AL549_RS04160	COG2197	response regulator
AL549_RS04180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL549_RS04180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL549_RS04190	COG0516	GMP reductase activity
AL549_RS04240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL549_RS04255	COG3568	Endonuclease Exonuclease Phosphatase
AL549_RS04280	COG0513	Belongs to the DEAD box helicase family
AL549_RS04295	COG1846	Transcriptional regulator
AL549_RS04325	COG0842	Transport permease protein
AL549_RS04330	COG1131	(ABC) transporter
AL549_RS04340	COG0837	glucose binding
AL549_RS04340	COG1737	Transcriptional regulator
AL549_RS04350	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AL549_RS04360	COG4145	pantothenate transmembrane transporter activity
AL549_RS04375	COG0251	oxidation-reduction process
AL549_RS04380	COG4251	negative regulation of phosphorylation
AL549_RS04380	COG5001	Diguanylate cyclase
AL549_RS04380	COG3706	GGDEF domain
AL549_RS04380	COG2203	Gaf domain
AL549_RS04385	COG0583	DNA-binding transcription factor activity
AL549_RS04390	COG2814	Major facilitator Superfamily
AL549_RS04405	COG0697	spore germination
AL549_RS04420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL549_RS04430	COG1764	response to oxidative stress
AL549_RS04435	COG1846	Transcriptional regulator
AL549_RS04460	COG1280	lysine exporter protein (LysE YggA)
AL549_RS04470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL549_RS04475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL549_RS04480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL549_RS04485	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AL549_RS04510	COG1612	heme a metabolic process
AL549_RS04515	COG0109	protoheme IX farnesyltransferase activity
AL549_RS04520	COG2885	chlorophyll binding
AL549_RS04525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL549_RS04530	COG0840	transmembrane signaling receptor activity
AL549_RS04570	COG2897	thiosulfate sulfurtransferase activity
AL549_RS04580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL549_RS04585	COG0303	'Molybdopterin
AL549_RS04590	COG0302	gtp cyclohydrolase
AL549_RS04595	COG1914	H( )-stimulated, divalent metal cation uptake system
AL549_RS04605	COG0038	chloride channel
AL549_RS04630	COG4989	oxidoreductase activity
AL549_RS04640	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL549_RS04660	COG0840	transmembrane signaling receptor activity
AL549_RS04665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL549_RS04670	COG0545	Peptidyl-prolyl cis-trans isomerase
AL549_RS04700	COG1278	Cold shock
AL549_RS04705	COG3036	rescue of stalled ribosome
AL549_RS04715	COG2203	Gaf domain
AL549_RS04715	COG2199	diguanylate cyclase activity
AL549_RS04725	COG1482	cell wall glycoprotein biosynthetic process
AL549_RS04730	COG2271	Major facilitator Superfamily
AL549_RS04735	COG3851	Histidine kinase
AL549_RS04740	COG2197	response regulator
AL549_RS04760	COG2130	NADP-dependent
AL549_RS04765	COG1309	transcriptional regulator
AL549_RS04780	COG1278	Cold shock
AL549_RS04785	COG3634	alkyl hydroperoxide reductase activity
AL549_RS04805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL549_RS04810	COG1960	acyl-CoA dehydrogenase activity
AL549_RS04820	COG0183	Belongs to the thiolase family
AL549_RS04830	COG1960	acyl-CoA dehydrogenase activity
AL549_RS04835	COG1024	Enoyl-CoA hydratase
AL549_RS04840	COG1024	Enoyl-CoA hydratase
AL549_RS04850	COG1028	Short-chain dehydrogenase reductase Sdr
AL549_RS04890	COG2994	toxin metabolic process
AL549_RS04895	COG1073	alpha beta
AL549_RS04895	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AL549_RS04895	COG3064	Membrane
AL549_RS04950	COG3437	response regulator, receiver
AL549_RS04950	COG0784	Response regulator, receiver
AL549_RS04955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL549_RS04955	COG4191	Histidine kinase
AL549_RS04965	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL549_RS04990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL549_RS04995	COG3186	Phenylalanine-4-hydroxylase
AL549_RS05000	COG2154	pterin-4-alpha-carbinolamine dehydratase
AL549_RS05020	COG3530	Putative quorum-sensing-regulated virulence factor
AL549_RS05040	COG0515	serine threonine protein kinase
AL549_RS05040	COG2815	serine threonine protein kinase
AL549_RS05075	COG0631	protein serine/threonine phosphatase activity
AL549_RS05205	COG0501	Belongs to the peptidase M48B family
AL549_RS05210	COG1704	LemA family
AL549_RS05215	COG3069	C4-dicarboxylate transmembrane transporter activity
AL549_RS05225	COG0312	modulator of DNA gyrase
AL549_RS05230	COG0312	modulator of DNA gyrase
AL549_RS05235	COG0584	glycerophosphoryl diester phosphodiesterase
AL549_RS05240	COG2271	Major facilitator Superfamily
AL549_RS05255	COG0840	transmembrane signaling receptor activity
AL549_RS05260	COG0840	transmembrane signaling receptor activity
AL549_RS05265	COG0366	Alpha amylase catalytic
AL549_RS05270	COG0456	acetyltransferase
AL549_RS05275	COG0243	molybdopterin cofactor binding
AL549_RS05280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL549_RS05280	COG1648	precorrin-2 dehydrogenase activity
AL549_RS05295	COG3707	response regulator
AL549_RS05300	COG1116	anion transmembrane transporter activity
AL549_RS05300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL549_RS05305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL549_RS05310	COG1116	anion transmembrane transporter activity
AL549_RS05315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL549_RS05315	COG2146	nitrite reductase [NAD(P)H] activity
AL549_RS05330	COG2199	diguanylate cyclase activity
AL549_RS05340	COG0523	cobalamin synthesis protein
AL549_RS05350	COG0513	Belongs to the DEAD box helicase family
AL549_RS05355	COG0010	Belongs to the arginase family
AL549_RS05365	COG3706	GGDEF domain
AL549_RS05365	COG2203	Gaf domain
AL549_RS05365	COG5001	Diguanylate cyclase
AL549_RS05365	COG4251	negative regulation of phosphorylation
AL549_RS05375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL549_RS05405	COG0840	transmembrane signaling receptor activity
AL549_RS05410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL549_RS05445	COG0811	peptide transport
AL549_RS05450	COG0811	peptide transport
AL549_RS05455	COG0848	biopolymer transport protein
AL549_RS05470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL549_RS05490	COG0534	Mate efflux family protein
AL549_RS05500	COG0477	Major facilitator Superfamily
AL549_RS05505	COG3118	belongs to the thioredoxin family
AL549_RS05510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL549_RS05565	COG1328	CTP reductase activity
AL549_RS05570	COG0602	queuosine metabolic process
AL549_RS05575	COG0840	transmembrane signaling receptor activity
AL549_RS05585	COG0189	ligase activity
AL549_RS05585	COG4067	protein conserved in archaea
AL549_RS05590	COG3385	transposase activity
AL549_RS05610	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL549_RS05615	COG4149	molybdate abc transporter
AL549_RS05625	COG0697	spore germination
AL549_RS05630	COG1846	Transcriptional regulator
AL549_RS05640	COG2199	diguanylate cyclase activity
AL549_RS05650	COG3706	GGDEF domain
AL549_RS05665	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL549_RS05670	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL549_RS05680	COG0745	RESPONSE REGULATOR receiver
AL549_RS05695	COG3140	Belongs to the UPF0181 family
AL549_RS05705	COG0023	Translation Initiation Factor
AL549_RS05715	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL549_RS05725	COG0045	succinate-CoA ligase (ADP-forming) activity
AL549_RS05725	COG1042	CoA-binding domain protein
AL549_RS05725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL549_RS05730	COG0583	DNA-binding transcription factor activity
AL549_RS05740	COG5002	protein histidine kinase activity
AL549_RS05740	COG5001	Diguanylate cyclase
AL549_RS05740	COG3447	MASE1 domain protein
AL549_RS05750	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL549_RS05755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL549_RS05760	COG1984	allophanate hydrolase subunit 2
AL549_RS05765	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL549_RS05765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL549_RS05770	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL549_RS05775	COG4181	ATPase activity
AL549_RS05785	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL549_RS05790	COG1716	ATPase activity
AL549_RS05790	COG5001	Diguanylate cyclase
AL549_RS05805	COG0484	heat shock protein binding
AL549_RS05825	COG0583	DNA-binding transcription factor activity
AL549_RS05830	COG0366	Alpha amylase catalytic
AL549_RS05840	COG4533	DNA binding
AL549_RS05850	COG2050	protein possibly involved in aromatic compounds catabolism
AL549_RS05865	COG2067	long-chain fatty acid transport protein
AL549_RS05870	COG2267	carboxylic ester hydrolase activity
AL549_RS05900	COG0861	Integral membrane protein TerC family
AL549_RS05905	COG0737	Belongs to the 5'-nucleotidase family
AL549_RS05910	COG3593	DNA synthesis involved in DNA repair
AL549_RS05920	COG0583	DNA-binding transcription factor activity
AL549_RS05925	COG2116	formate transmembrane transporter activity
AL549_RS05930	COG2353	YceI-like domain
AL549_RS05935	COG3038	cytochrome b561
AL549_RS05950	COG0513	Belongs to the DEAD box helicase family
AL549_RS05970	COG0546	phosphoglycolate phosphatase activity
AL549_RS05975	COG0784	Response regulator, receiver
AL549_RS05975	COG3437	response regulator, receiver
AL549_RS05990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL549_RS06010	COG2207	Transcriptional regulator
AL549_RS06015	COG1979	alcohol dehydrogenase
AL549_RS06025	COG4191	Histidine kinase
AL549_RS06035	COG2271	Major facilitator Superfamily
AL549_RS06040	COG0469	pyruvate kinase activity
AL549_RS06065	COG1609	Transcriptional regulator
AL549_RS06070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL549_RS06070	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL549_RS06075	COG1105	Belongs to the carbohydrate kinase PfkB family
AL549_RS06080	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL549_RS06080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL549_RS06080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL549_RS06125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL549_RS06130	COG0509	glycine decarboxylation via glycine cleavage system
AL549_RS06135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL549_RS06135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL549_RS06155	COG1132	(ABC) transporter
AL549_RS06165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL549_RS06195	COG2814	Major facilitator Superfamily
AL549_RS06225	COG0641	radical SAM
AL549_RS06235	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
AL549_RS06270	COG0714	Associated with various cellular activities
AL549_RS06275	COG0641	radical SAM
AL549_RS06280	COG3119	arylsulfatase activity
AL549_RS06290	COG3119	arylsulfatase activity
AL549_RS06295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL549_RS06300	COG0513	Belongs to the DEAD box helicase family
AL549_RS06305	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL549_RS06320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL549_RS06345	COG1716	ATPase activity
AL549_RS06345	COG5001	Diguanylate cyclase
AL549_RS06350	COG2205	protein histidine kinase activity
AL549_RS06350	COG0784	Response regulator, receiver
AL549_RS06355	COG0513	Belongs to the DEAD box helicase family
AL549_RS06380	COG3005	denitrification pathway
AL549_RS06385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL549_RS06410	COG1879	ABC-type sugar transport system periplasmic component
AL549_RS06415	COG1803	Methylglyoxal synthase
AL549_RS06420	COG0210	DNA helicase
AL549_RS06425	COG1289	transmembrane transporter activity
AL549_RS06455	COG0789	Transcriptional regulator
AL549_RS06460	COG4604	ABC transporter, ATP-binding protein
AL549_RS06465	COG4605	iron ion homeostasis
AL549_RS06470	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL549_RS06490	COG0110	maltose O-acetyltransferase activity
AL549_RS06500	COG3290	protein histidine kinase activity
AL549_RS06505	COG0471	metal ion transport
AL549_RS06590	COG4964	Belongs to the GSP D family
AL549_RS06610	COG0583	DNA-binding transcription factor activity
AL549_RS06620	COG0419	ATPase involved in DNA repair
AL549_RS06625	COG0420	3'-5' exonuclease activity
AL549_RS06645	COG0456	acetyltransferase
AL549_RS06655	COG0784	Response regulator, receiver
AL549_RS06655	COG0835	chemotaxis
AL549_RS06665	COG1609	Transcriptional regulator
AL549_RS06670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL549_RS06675	COG1879	ABC-type sugar transport system periplasmic component
AL549_RS06680	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL549_RS06685	COG1129	ABC transporter
AL549_RS06690	COG1869	D-ribose catabolic process
AL549_RS06705	COG2315	Protein conserved in bacteria
AL549_RS06710	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL549_RS06725	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL549_RS06740	COG1288	antiporter activity
AL549_RS06750	COG0671	phosphoesterase, PA-phosphatase related
AL549_RS06765	COG2962	Rard protein
AL549_RS06790	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL549_RS06795	COG0814	amino acid
AL549_RS06820	COG3174	membrane
AL549_RS06825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL549_RS06855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL549_RS06860	COG0443	Heat shock 70 kDa protein
AL549_RS06865	COG1454	alcohol dehydrogenase
AL549_RS06875	COG2133	pyrroloquinoline quinone binding
AL549_RS06880	COG1619	proteins homologs of microcin C7 resistance protein MccF
AL549_RS06895	COG0247	lactate metabolic process
AL549_RS06905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL549_RS06925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL549_RS06935	COG3059	membrane
AL549_RS06940	COG4175	Glycine betaine
AL549_RS06960	COG1012	belongs to the aldehyde dehydrogenase family
AL549_RS06965	COG1309	transcriptional regulator
AL549_RS06985	COG1686	Belongs to the peptidase S11 family
AL549_RS07005	COG1760	l-serine dehydratase
AL549_RS07010	COG3104	oligopeptide transport
AL549_RS07020	COG0583	DNA-binding transcription factor activity
AL549_RS07025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL549_RS07045	COG3842	ATPase activity
AL549_RS07055	COG1840	ABC-type Fe3 transport system, periplasmic component
AL549_RS07060	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL549_RS07065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL549_RS07070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL549_RS07075	COG2207	Transcriptional regulator
AL549_RS07075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL549_RS07080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL549_RS07105	COG1011	Hydrolase
AL549_RS07130	COG1765	OsmC-like protein
AL549_RS07135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL549_RS07135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL549_RS07140	COG3706	GGDEF domain
AL549_RS07155	COG0840	transmembrane signaling receptor activity
AL549_RS07175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL549_RS07200	COG2084	Dehydrogenase
AL549_RS07210	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AL549_RS07220	COG0739	heme binding
AL549_RS07240	COG3314	Sporulation integral membrane protein YlbJ
AL549_RS07255	COG0840	transmembrane signaling receptor activity
AL549_RS07265	COG0366	Alpha amylase catalytic
AL549_RS07270	COG0589	response to stress
AL549_RS07275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL549_RS07280	COG0835	chemotaxis
AL549_RS07280	COG0784	Response regulator, receiver
AL549_RS07290	COG0748	coenzyme F420 binding
AL549_RS07295	COG3721	Heme iron utilization protein
AL549_RS07305	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL549_RS07310	COG0811	peptide transport
AL549_RS07315	COG0848	biopolymer transport protein
AL549_RS07325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL549_RS07330	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL549_RS07355	COG3025	triphosphatase activity
AL549_RS07360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL549_RS07370	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL549_RS07380	COG1538	Outer membrane efflux protein
AL549_RS07385	COG0494	nUDIX hydrolase
AL549_RS07390	COG3151	Protein conserved in bacteria
AL549_RS07400	COG3150	esterase
AL549_RS07415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL549_RS07420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL549_RS07425	COG3105	Protein conserved in bacteria
AL549_RS07430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL549_RS07440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL549_RS07445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL549_RS07450	COG0723	plastoquinol--plastocyanin reductase activity
AL549_RS07455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL549_RS07460	COG2857	Cytochrome c1
AL549_RS07465	COG0625	glutathione transferase activity
AL549_RS07470	COG2969	positive regulation of protein catabolic process
AL549_RS07475	COG2823	Periplasmic or secreted lipoprotein
AL549_RS07480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL549_RS07485	COG0792	nuclease activity
AL549_RS07490	COG3107	peptidoglycan biosynthetic process
AL549_RS07495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL549_RS07505	COG0275	rRNA processing
AL549_RS07510	COG3116	cell division
AL549_RS07515	COG0768	penicillin binding
AL549_RS07525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL549_RS07530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL549_RS07540	COG0772	Belongs to the SEDS family
AL549_RS07550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL549_RS07555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL549_RS07560	COG0849	cell division
AL549_RS07565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL549_RS07570	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL549_RS07580	COG0653	protein targeting
AL549_RS07585	COG0494	nUDIX hydrolase
AL549_RS07595	COG0505	Belongs to the CarA family
AL549_RS07600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL549_RS07615	COG0730	response to heat
AL549_RS07620	COG0583	DNA-binding transcription factor activity
AL549_RS07625	COG2860	membrane
AL549_RS07630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL549_RS07635	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AL549_RS07640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL549_RS07650	COG0493	'glutamate synthase
AL549_RS07655	COG0069	glutamate synthase activity
AL549_RS07655	COG0067	glutamate synthase
AL549_RS07655	COG0070	glutamate synthase
AL549_RS07665	COG0069	glutamate synthase activity
AL549_RS07665	COG0067	glutamate synthase
AL549_RS07665	COG0070	glutamate synthase
AL549_RS07670	COG1242	4 iron, 4 sulfur cluster binding
AL549_RS07675	COG5001	Diguanylate cyclase
AL549_RS07675	COG2203	Gaf domain
AL549_RS07675	COG4251	negative regulation of phosphorylation
AL549_RS07675	COG3706	GGDEF domain
AL549_RS07680	COG0784	Response regulator, receiver
AL549_RS07680	COG5002	protein histidine kinase activity
AL549_RS07680	COG2198	Histidine kinase
AL549_RS07690	COG0745	RESPONSE REGULATOR receiver
AL549_RS07705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL549_RS07720	COG0083	homoserine kinase activity
AL549_RS07725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL549_RS07730	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL549_RS07740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL549_RS07755	COG1115	amino acid carrier protein
AL549_RS07760	COG3022	response to hydroperoxide
AL549_RS07765	COG0513	Belongs to the DEAD box helicase family
AL549_RS07785	COG4974	Belongs to the 'phage' integrase family
AL549_RS07790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL549_RS07795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL549_RS07820	COG0667	Aldo Keto reductase
AL549_RS07830	COG3066	DNA modification
AL549_RS07835	COG0494	nUDIX hydrolase
AL549_RS07845	COG0730	response to heat
AL549_RS07865	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL549_RS07870	COG0583	DNA-binding transcription factor activity
AL549_RS07875	COG0640	Transcriptional regulator
AL549_RS07880	COG0268	Binds directly to 16S ribosomal RNA
AL549_RS07885	COG0728	peptidoglycan biosynthetic process
AL549_RS07890	COG0196	riboflavin kinase activity
AL549_RS07895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL549_RS07900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL549_RS07905	COG1047	Peptidyl-prolyl cis-trans
AL549_RS07910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL549_RS07920	COG3275	phosphorelay sensor kinase activity
AL549_RS07925	COG1966	Carbon starvation protein
AL549_RS07945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL549_RS07960	COG0287	Prephenate dehydrogenase
AL549_RS07960	COG1605	Chorismate mutase
AL549_RS07965	COG0739	heme binding
AL549_RS07975	COG0488	(ABC) transporter
AL549_RS07985	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL549_RS07995	COG0077	Prephenate dehydratase
AL549_RS07995	COG1605	Chorismate mutase
AL549_RS08000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL549_RS08005	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL549_RS08020	COG0542	response to heat
AL549_RS08060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL549_RS08065	COG0826	peptidase U32
AL549_RS08075	COG0745	RESPONSE REGULATOR receiver
AL549_RS08080	COG5002	protein histidine kinase activity
AL549_RS08090	COG0248	Ppx GppA phosphatase
AL549_RS08095	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL549_RS08100	COG0573	inorganic phosphate transmembrane transporter activity
AL549_RS08105	COG0581	inorganic phosphate transmembrane transporter activity
AL549_RS08110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL549_RS08115	COG0704	Plays a role in the regulation of phosphate uptake
AL549_RS08150	COG0450	alkyl hydroperoxide reductase
AL549_RS08155	COG0583	DNA-binding transcription factor activity
AL549_RS08160	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL549_RS08170	COG0517	IMP dehydrogenase activity
AL549_RS08180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL549_RS08185	COG0343	queuine tRNA-ribosyltransferase activity
AL549_RS08190	COG1862	Preprotein translocase
AL549_RS08195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL549_RS08200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL549_RS08215	COG0483	inositol monophosphate 1-phosphatase activity
AL549_RS08220	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL549_RS08225	COG1959	2 iron, 2 sulfur cluster binding
AL549_RS08235	COG0822	iron-sulfur transferase activity
AL549_RS08240	COG0316	Belongs to the HesB IscA family
AL549_RS08255	COG0633	Ferredoxin
AL549_RS08260	COG2975	iron-sulfur cluster assembly
AL549_RS08265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL549_RS08270	COG0105	UTP biosynthetic process
AL549_RS08275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL549_RS08285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL549_RS08290	COG0124	histidyl-tRNA synthetase
AL549_RS08295	COG2976	Protein conserved in bacteria
AL549_RS08300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL549_RS08315	COG2199	diguanylate cyclase activity
AL549_RS08315	COG2203	Gaf domain
AL549_RS08330	COG0516	GMP reductase activity
AL549_RS08330	COG0517	IMP dehydrogenase activity
AL549_RS08335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL549_RS08335	COG0519	Catalyzes the synthesis of GMP from XMP
AL549_RS08345	COG1584	GPR1 FUN34 yaaH family protein
AL549_RS08350	COG1115	amino acid carrier protein
AL549_RS08355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL549_RS08360	COG0583	DNA-binding transcription factor activity
AL549_RS08380	COG0009	L-threonylcarbamoyladenylate synthase
AL549_RS08430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL549_RS08435	COG2867	negative regulation of translational initiation
AL549_RS08440	COG2914	Belongs to the UPF0125 (RnfH) family
AL549_RS08445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL549_RS08450	COG0497	DNA recombination
AL549_RS08455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL549_RS08460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL549_RS08490	COG0443	Heat shock 70 kDa protein
AL549_RS08495	COG0484	heat shock protein binding
AL549_RS08505	COG4969	Belongs to the N-Me-Phe pilin family
AL549_RS08525	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL549_RS08530	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AL549_RS08535	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL549_RS08540	COG0583	DNA-binding transcription factor activity
AL549_RS08555	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL549_RS08585	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL549_RS08590	COG2252	PERMEase
AL549_RS08595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL549_RS08600	COG1073	alpha beta
AL549_RS08610	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL549_RS08620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL549_RS08625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL549_RS08625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL549_RS08640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL549_RS08645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL549_RS08650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL549_RS08655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL549_RS08660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL549_RS08665	COG0142	geranyltranstransferase activity
AL549_RS08670	COG1722	exodeoxyribonuclease VII activity
AL549_RS08675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL549_RS08690	COG0583	DNA-binding transcription factor activity
AL549_RS08700	COG2363	Small membrane protein
AL549_RS08715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL549_RS08720	COG1611	Belongs to the LOG family
AL549_RS08745	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL549_RS08750	COG1464	Belongs to the NlpA lipoprotein family
AL549_RS08755	COG2011	ABC-type metal ion transport system permease component
AL549_RS08760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL549_RS08765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL549_RS08775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL549_RS08775	COG1263	PTS System
AL549_RS08780	COG0366	Alpha amylase catalytic
AL549_RS08790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL549_RS08800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL549_RS08810	COG2921	Belongs to the UPF0250 family
AL549_RS08815	COG1686	Belongs to the peptidase S11 family
AL549_RS08820	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL549_RS08825	COG0772	Belongs to the SEDS family
AL549_RS08830	COG0768	penicillin binding
AL549_RS08835	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL549_RS08840	COG0799	negative regulation of ribosome biogenesis
AL549_RS08845	COG1466	dna polymerase III delta subunit
AL549_RS08850	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL549_RS08860	COG2888	peptidyl-tyrosine sulfation
AL549_RS08870	COG4535	Mg2 and Co2 transporter CorC
AL549_RS08875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL549_RS08880	COG1702	phosphate starvation-inducible protein PhoH
AL549_RS08890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL549_RS08980	COG0193	aminoacyl-tRNA hydrolase activity
AL549_RS08985	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL549_RS08990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL549_RS09000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL549_RS09005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL549_RS09010	COG2890	protein-(glutamine-N5) methyltransferase activity
AL549_RS09020	COG2912	Transglutaminase-like superfamily
AL549_RS09025	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL549_RS09040	COG1187	pseudouridine synthase activity
AL549_RS09045	COG2840	Smr protein MutS2
AL549_RS09060	COG3735	TraB family
AL549_RS09075	COG2217	Heavy metal translocating P-type atpase
AL549_RS09075	COG2608	mercury ion transmembrane transporter activity
AL549_RS09090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL549_RS09120	COG3385	transposase activity
AL549_RS09140	COG0784	Response regulator, receiver
AL549_RS09140	COG0835	chemotaxis
AL549_RS09145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL549_RS09150	COG1815	bacterial-type flagellum-dependent cell motility
AL549_RS09165	COG1749	Flagellar hook protein flgE
AL549_RS09170	COG4787	bacterial-type flagellum-dependent cell motility
AL549_RS09185	COG1706	bacterial-type flagellum-dependent cell motility
AL549_RS09190	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL549_RS09190	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL549_RS09200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL549_RS09205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL549_RS09210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL549_RS09215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL549_RS09220	COG2190	(PTS) system
AL549_RS09225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL549_RS09230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL549_RS09235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL549_RS09240	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL549_RS09270	COG0330	HflC and HflK could
AL549_RS09275	COG3118	belongs to the thioredoxin family
AL549_RS09285	COG0300	oxidoreductase activity
AL549_RS09290	COG1090	epimerase
AL549_RS09315	COG0622	Phosphoesterase
AL549_RS09335	COG3710	Transcriptional regulator
AL549_RS09350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL549_RS09355	COG0840	transmembrane signaling receptor activity
AL549_RS09360	COG3104	oligopeptide transport
AL549_RS09370	COG0367	asparagine synthase
AL549_RS09375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL549_RS09375	COG4651	solute:proton antiporter activity
AL549_RS09380	COG1940	carbohydrate kinase activity
AL549_RS09380	COG1846	Transcriptional regulator
AL549_RS09385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL549_RS09390	COG1263	PTS System
AL549_RS09390	COG2190	(PTS) system
AL549_RS09390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL549_RS09395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL549_RS09410	COG0716	FMN binding
AL549_RS09420	COG0596	Alpha beta hydrolase
AL549_RS09425	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL549_RS09430	COG0033	Phosphoglucomutase
AL549_RS09435	COG2964	Protein conserved in bacteria
AL549_RS09440	COG0251	oxidation-reduction process
AL549_RS09450	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL549_RS09460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL549_RS09470	COG2009	succinate dehydrogenase
AL549_RS09475	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL549_RS09480	COG1053	succinate dehydrogenase
AL549_RS09490	COG0567	Dehydrogenase, E1 component
AL549_RS09495	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL549_RS09510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL549_RS09515	COG1121	(ABC) transporter
AL549_RS09520	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL549_RS09530	COG1918	ferrous iron import across plasma membrane
AL549_RS09535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AL549_RS09555	COG3102	Protein conserved in bacteria
AL549_RS09560	COG0788	formyltetrahydrofolate deformylase activity
AL549_RS09570	COG1199	ATP-dependent helicase activity
AL549_RS09575	COG1214	PFAM Peptidase M22, glycoprotease
AL549_RS09590	COG0596	Alpha beta hydrolase
AL549_RS09595	COG0318	PFAM AMP-dependent synthetase and ligase
AL549_RS09600	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL549_RS09605	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL549_RS09610	COG2894	cell division
AL549_RS09615	COG0850	regulation of cytokinetic process
AL549_RS09625	COG2951	lytic endotransglycosylase activity
AL549_RS09635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL549_RS09645	COG0745	RESPONSE REGULATOR receiver
AL549_RS09650	COG5002	protein histidine kinase activity
AL549_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
AL549_RS09675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL549_RS09700	COG2986	histidine ammonia-lyase
AL549_RS09705	COG1216	Glycosyl transferase, family 2
AL549_RS09715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL549_RS09725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL549_RS09730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL549_RS09795	COG1175	transmembrane transport
AL549_RS09805	COG3842	ATPase activity
AL549_RS09810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL549_RS09815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL549_RS09820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL549_RS09830	COG2204	response regulator
AL549_RS09835	COG4191	Histidine kinase
AL549_RS09850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL549_RS09855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL549_RS09860	COG0776	regulation of translation
AL549_RS09865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL549_RS09870	COG1555	photosystem II stabilization
AL549_RS09885	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL549_RS09890	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL549_RS09895	COG0436	Aminotransferase
AL549_RS09900	COG1169	isochorismate synthase
AL549_RS09915	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL549_RS09925	COG0318	PFAM AMP-dependent synthetase and ligase
AL549_RS09980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL549_RS09985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL549_RS10000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL549_RS10005	COG1522	sequence-specific DNA binding
AL549_RS10015	COG1946	Acyl-CoA thioesterase
AL549_RS10020	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL549_RS10035	COG5001	Diguanylate cyclase
AL549_RS10075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL549_RS10090	COG3139	Protein of unknown function (DUF1315)
AL549_RS10095	COG0252	asparaginase activity
AL549_RS10100	COG0616	signal peptide processing
AL549_RS10105	COG1902	pentaerythritol trinitrate reductase activity
AL549_RS10105	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL549_RS10110	COG0778	Nitroreductase
AL549_RS10115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL549_RS10120	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL549_RS10125	COG0784	Response regulator, receiver
AL549_RS10125	COG2205	protein histidine kinase activity
AL549_RS10135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL549_RS10140	COG2731	YhcH YjgK YiaL family protein
AL549_RS10145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL549_RS10150	COG0569	domain protein
AL549_RS10160	COG3083	sulfuric ester hydrolase activity
AL549_RS10170	COG3081	Nucleoid-associated protein
AL549_RS10185	COG1757	Na H antiporter
AL549_RS10190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL549_RS10200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL549_RS10205	COG2095	MarC family integral membrane protein
AL549_RS10210	COG1454	alcohol dehydrogenase
AL549_RS10210	COG1012	belongs to the aldehyde dehydrogenase family
AL549_RS10215	COG1028	Short-chain dehydrogenase reductase Sdr
AL549_RS10230	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL549_RS10240	COG2056	Na+-H+ antiporter family
AL549_RS10245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL549_RS10250	COG2885	chlorophyll binding
AL549_RS10260	COG0346	lactoylglutathione lyase activity
AL549_RS10265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL549_RS10270	COG4660	Part of a membrane complex involved in electron transport
AL549_RS10275	COG4659	FMN binding
AL549_RS10280	COG4658	electron transport chain
AL549_RS10285	COG4656	Part of a membrane complex involved in electron transport
AL549_RS10290	COG2878	Part of a membrane complex involved in electron transport
AL549_RS10295	COG4657	Part of a membrane complex involved in electron transport
AL549_RS10305	COG0556	nucleotide-excision repair
AL549_RS10310	COG2204	response regulator
AL549_RS10315	COG2198	Histidine kinase
AL549_RS10320	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL549_RS10330	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL549_RS10340	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL549_RS10345	COG0314	molybdopterin synthase activity
AL549_RS10355	COG0601	transmembrane transport
AL549_RS10360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL549_RS10365	COG0444	Belongs to the ABC transporter superfamily
AL549_RS10375	COG0435	Glutathione S-transferase
AL549_RS10385	COG2350	Protein conserved in bacteria
AL549_RS10405	COG1301	dicarboxylic acid transport
AL549_RS10415	COG0133	tryptophan synthase activity
AL549_RS10420	COG0134	indole-3-glycerol-phosphate synthase activity
AL549_RS10420	COG0135	phosphoribosylanthranilate isomerase activity
AL549_RS10430	COG0512	Glutamine amidotransferase of anthranilate synthase
AL549_RS10435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL549_RS10445	COG0613	PHP domain protein
AL549_RS10450	COG0009	L-threonylcarbamoyladenylate synthase
AL549_RS10470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL549_RS10480	COG5001	Diguanylate cyclase
AL549_RS10485	COG0417	DNA replication proofreading
AL549_RS10490	COG2197	response regulator
AL549_RS10560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL549_RS10565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL549_RS10570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL549_RS10595	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL549_RS10600	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL549_RS10605	COG0437	4 iron, 4 sulfur cluster binding
AL549_RS10610	COG3301	Polysulphide reductase, NrfD
AL549_RS10615	COG1138	Cytochrome C-type biogenesis protein
AL549_RS10620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL549_RS10625	COG3088	subunit of a heme lyase
AL549_RS10625	COG4235	cytochrome complex assembly
AL549_RS10635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL549_RS10635	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL549_RS10640	COG0489	protein tyrosine kinase activity
AL549_RS10645	COG0572	uridine kinase
AL549_RS10660	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL549_RS10665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL549_RS10670	COG0659	secondary active sulfate transmembrane transporter activity
AL549_RS10675	COG1530	ribonuclease E activity
AL549_RS10685	COG0424	maF-like protein
AL549_RS10690	COG1399	metal-binding, possibly nucleic acid-binding protein
AL549_RS10695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL549_RS10700	COG0416	fatty acid biosynthetic process
AL549_RS10705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL549_RS10720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL549_RS10735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL549_RS10740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL549_RS10750	COG0084	hydrolase, TatD family'
AL549_RS10755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL549_RS10755	COG1263	PTS System
AL549_RS10770	COG0733	neurotransmitter:sodium symporter activity
AL549_RS10785	COG4667	esterase of the alpha-beta hydrolase superfamily
AL549_RS10790	COG0469	pyruvate kinase activity
AL549_RS10795	COG1940	carbohydrate kinase activity
AL549_RS10800	COG0835	chemotaxis
AL549_RS10800	COG0784	Response regulator, receiver
AL549_RS10805	COG0587	DNA-directed DNA polymerase activity
AL549_RS10820	COG1028	Short-chain dehydrogenase reductase Sdr
AL549_RS10825	COG0616	signal peptide processing
AL549_RS10835	COG0539	negative regulation of cytoplasmic translation
AL549_RS10845	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL549_RS10850	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL549_RS10855	COG0284	orotidine-5'-phosphate decarboxylase activity
AL549_RS10860	COG4174	ABC transporter (Permease)
AL549_RS10865	COG4239	(ABC) transporter, permease
AL549_RS10870	COG4166	transmembrane transport
AL549_RS10875	COG0444	Belongs to the ABC transporter superfamily
AL549_RS10880	COG4608	Belongs to the ABC transporter superfamily
AL549_RS10920	COG2989	Protein conserved in bacteria
AL549_RS10925	COG3108	Peptidase M15
AL549_RS10930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL549_RS10960	COG0583	DNA-binding transcription factor activity
AL549_RS10970	COG0686	Belongs to the AlaDH PNT family
AL549_RS10985	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL549_RS10990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL549_RS11000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL549_RS11005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL549_RS11010	COG0156	8-amino-7-oxononanoate synthase activity
AL549_RS11020	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL549_RS11025	COG0501	Belongs to the peptidase M48B family
AL549_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
AL549_RS11050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL549_RS11075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL549_RS11080	COG2915	High frequency lysogenization protein hflD homolog
AL549_RS11095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL549_RS11100	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL549_RS11105	COG1757	Na H antiporter
AL549_RS11110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL549_RS11120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL549_RS11125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL549_RS11125	COG0131	Imidazoleglycerol-phosphate dehydratase
AL549_RS11130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL549_RS11145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL549_RS11145	COG0140	phosphoribosyl-ATP diphosphatase activity
AL549_RS11150	COG3012	SEC-C Motif Domain Protein
AL549_RS11155	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL549_RS11160	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL549_RS11165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL549_RS11170	COG0215	cysteine-tRNA ligase activity
AL549_RS11175	COG1435	thymidine kinase activity
AL549_RS11185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL549_RS11190	COG0583	DNA-binding transcription factor activity
AL549_RS11210	COG2116	formate transmembrane transporter activity
AL549_RS11215	COG0390	transport system, permease component
AL549_RS11220	COG4459	periplasmic nitrate reductase
AL549_RS11225	COG3005	denitrification pathway
AL549_RS11260	COG1227	inorganic diphosphatase activity
AL549_RS11275	COG4172	Belongs to the ABC transporter superfamily
AL549_RS11300	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL549_RS11305	COG1842	Phage shock protein A
AL549_RS11315	COG1983	PspC domain protein
AL549_RS11335	COG2818	Glycosylase
AL549_RS11340	COG0626	cystathionine gamma-synthase activity
AL549_RS11350	COG0733	neurotransmitter:sodium symporter activity
AL549_RS11360	COG0564	pseudouridine synthase activity
AL549_RS11370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL549_RS11375	COG1151	hydroxylamine reductase activity
AL549_RS11380	COG3604	Transcriptional regulator
AL549_RS11385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL549_RS11390	COG4136	ATPase activity
AL549_RS11395	COG4135	transport system, permease component
AL549_RS11400	COG4134	Bacterial extracellular solute-binding protein
AL549_RS11410	COG3313	Fe-S protein
AL549_RS11440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL549_RS11445	COG2205	protein histidine kinase activity
AL549_RS11460	COG1061	Type III restriction enzyme res subunit
AL549_RS11470	COG2814	Major facilitator Superfamily
AL549_RS11485	COG0702	epimerase
AL549_RS11490	COG1136	(ABC) transporter
AL549_RS11505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL549_RS11525	COG3273	potassium ion transport
AL549_RS11525	COG2985	domain, Protein
AL549_RS11530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL549_RS11535	COG1979	alcohol dehydrogenase
AL549_RS11540	COG1737	Transcriptional regulator
AL549_RS11545	COG0076	glutamate decarboxylase activity
AL549_RS11555	COG2431	L-lysine efflux transmembrane transporter activity
AL549_RS11565	COG3070	regulator of competence-specific genes
AL549_RS11580	COG5002	protein histidine kinase activity
AL549_RS11580	COG5002	protein histidine kinase activity
AL549_RS11590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL549_RS11595	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL549_RS11600	COG4988	ABC transporter
AL549_RS11605	COG0492	ferredoxin-NADP+ reductase activity
AL549_RS11630	COG0471	metal ion transport
AL549_RS11635	COG2949	membrane
AL549_RS11640	COG0281	malic enzyme
AL549_RS11645	COG1643	Atp-dependent helicase
AL549_RS11660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL549_RS11670	COG1346	cytolysis
AL549_RS11675	COG1380	Effector of murein hydrolase LrgA
AL549_RS11680	COG2925	Exonuclease
AL549_RS11700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL549_RS11730	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL549_RS11760	COG1451	nucleotide metabolic process
AL549_RS11775	COG3063	Type IV pilus biogenesis stability protein PilW
AL549_RS11785	COG0737	Belongs to the 5'-nucleotidase family
AL549_RS11790	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL549_RS11800	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL549_RS11810	COG0625	glutathione transferase activity
AL549_RS11850	COG1278	Cold shock
AL549_RS11865	COG0584	glycerophosphoryl diester phosphodiesterase
AL549_RS11870	COG1349	DNA-binding transcription factor activity
AL549_RS11880	COG0395	ABC-type sugar transport system, permease component
AL549_RS11885	COG1175	transmembrane transport
AL549_RS11890	COG1653	transport
AL549_RS11905	COG0730	response to heat
AL549_RS11910	COG2197	response regulator
AL549_RS11955	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL549_RS11960	COG0732	type I restriction modification DNA specificity domain
AL549_RS11970	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL549_RS11975	COG0372	Belongs to the citrate synthase family
AL549_RS11980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL549_RS11985	COG2828	Protein conserved in bacteria
AL549_RS12015	COG0561	phosphatase activity
AL549_RS12020	COG0602	queuosine metabolic process
AL549_RS12025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL549_RS12030	COG3706	GGDEF domain
AL549_RS12055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL549_RS12065	COG1254	Belongs to the acylphosphatase family
AL549_RS12070	COG2920	part of a sulfur-relay system
AL549_RS12080	COG0670	Belongs to the BI1 family
AL549_RS12085	COG1126	abc transporter atp-binding protein
AL549_RS12090	COG0765	amino acid transport
AL549_RS12095	COG4597	amino acid ABC transporter
AL549_RS12100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL549_RS12110	COG0437	4 iron, 4 sulfur cluster binding
AL549_RS12115	COG0348	domain, Protein
AL549_RS12120	COG0204	Acyl-transferase
AL549_RS12125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL549_RS12140	COG1115	amino acid carrier protein
AL549_RS12165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL549_RS12180	COG3290	protein histidine kinase activity
AL549_RS12185	COG4565	transcriptional regulatory protein
AL549_RS12190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL549_RS12195	COG0363	glucosamine-6-phosphate deaminase activity
AL549_RS12200	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL549_RS12235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL549_RS12245	COG0438	transferase activity, transferring glycosyl groups
AL549_RS12260	COG0110	maltose O-acetyltransferase activity
AL549_RS12290	COG2204	response regulator
AL549_RS12320	COG1366	Belongs to the anti-sigma-factor antagonist family
AL549_RS12325	COG1793	dna ligase
AL549_RS12330	COG3706	GGDEF domain
AL549_RS12340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL549_RS12355	COG2996	Protein conserved in bacteria
AL549_RS12360	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AL549_RS12360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL549_RS12365	COG3008	intermembrane lipid transfer
AL549_RS12370	COG2995	paraquat-inducible protein a
AL549_RS12375	COG1132	(ABC) transporter
AL549_RS12380	COG1956	GAF domain-containing protein
AL549_RS12385	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL549_RS12400	COG0308	aminopeptidase N
AL549_RS12410	COG2902	Dehydrogenase
AL549_RS12425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL549_RS12425	COG0116	Belongs to the methyltransferase superfamily
AL549_RS12435	COG0488	(ABC) transporter
AL549_RS12450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL549_RS12455	COG1067	ATP-dependent peptidase activity
AL549_RS12460	COG3120	sequence-specific DNA binding
AL549_RS12495	COG3278	Belongs to the heme-copper respiratory oxidase family
AL549_RS12510	COG2010	Cytochrome c
AL549_RS12520	COG2217	Heavy metal translocating P-type atpase
AL549_RS12535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL549_RS12540	COG0589	response to stress
AL549_RS12545	COG0037	tRNA processing
AL549_RS12550	COG3385	transposase activity
AL549_RS12560	COG2992	FlgJ-related protein
AL549_RS12570	COG3842	ATPase activity
AL549_RS12575	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL549_RS12580	COG1177	transmembrane transport
AL549_RS12590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL549_RS12595	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL549_RS12600	COG0004	ammonium transporteR
AL549_RS12635	COG0437	4 iron, 4 sulfur cluster binding
AL549_RS12640	COG0243	molybdopterin cofactor binding
AL549_RS12640	COG3383	formate dehydrogenase (NAD+) activity
AL549_RS12670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL549_RS12680	COG0488	(ABC) transporter
AL549_RS12695	COG3852	Histidine kinase
AL549_RS12700	COG2204	response regulator
AL549_RS12710	COG4662	Binding-protein-dependent transport system inner membrane component
AL549_RS12715	COG3842	ATPase activity
AL549_RS12720	COG0746	molybdenum cofactor guanylyltransferase activity
AL549_RS12735	COG1940	carbohydrate kinase activity
AL549_RS12740	COG3148	PFAM DTW domain containing protein
AL549_RS12750	COG0840	transmembrane signaling receptor activity
AL549_RS12755	COG0791	NLP P60 protein
AL549_RS12765	COG3706	GGDEF domain
AL549_RS12785	COG0307	riboflavin synthase, alpha
AL549_RS12790	COG0534	Mate efflux family protein
AL549_RS12825	COG2801	Transposase and inactivated derivatives
AL549_RS12915	COG2801	Transposase and inactivated derivatives
AL549_RS13100	COG1942	4-Oxalocrotonate Tautomerase
AL549_RS13185	COG0625	glutathione transferase activity
AL549_RS13285	COG1942	4-Oxalocrotonate Tautomerase
AL549_RS13350	COG0625	glutathione transferase activity
AL549_RS13635	COG4628	conserved protein (DUF2132)
AL549_RS14225	COG2801	Transposase and inactivated derivatives
AL549_RS14585	COG3738	Protein conserved in bacteria
AL549_RS14635	COG1011	Hydrolase
AL549_RS14730	COG0346	lactoylglutathione lyase activity
AL549_RS15050	COG1942	4-Oxalocrotonate Tautomerase
AL549_RS15255	COG4115	mRNA cleavage
AL549_RS15260	COG2161	toxin-antitoxin pair type II binding
AL549_RS15285	COG1280	lysine exporter protein (LysE YggA)
AL549_RS15335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL549_RS15355	COG4326	sporulation control protein
AL549_RS15365	COG1228	amidohydrolase
AL549_RS15390	COG5640	endopeptidase activity
AL549_RS15395	COG2020	methyltransferase activity
AL549_RS15400	COG0247	lactate metabolic process
AL549_RS15400	COG0277	FAD linked oxidase domain protein
AL549_RS15415	COG2885	chlorophyll binding
AL549_RS15435	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL549_RS15440	COG0500	methyltransferase
AL549_RS15450	COG0776	regulation of translation
AL549_RS15465	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL549_RS15470	COG0072	phenylalanine-tRNA ligase activity
AL549_RS15470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL549_RS15475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL549_RS15535	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AL549_RS15540	COG1166	arginine decarboxylase activity
AL549_RS15545	COG0010	Belongs to the arginase family
AL549_RS15550	COG0840	transmembrane signaling receptor activity
AL549_RS15565	COG2814	Major facilitator Superfamily
AL549_RS15580	COG3279	Response regulator of the LytR AlgR family
AL549_RS15590	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL549_RS15615	COG1643	Atp-dependent helicase
AL549_RS15630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL549_RS15670	COG2894	cell division
AL549_RS15680	COG4964	Belongs to the GSP D family
AL549_RS15730	COG3706	GGDEF domain
AL549_RS15745	COG0443	Heat shock 70 kDa protein
AL549_RS15760	COG1917	Cupin 2, conserved barrel domain protein
AL549_RS15760	COG2169	Transcriptional regulator
AL549_RS15785	COG2165	general secretion pathway protein
AL549_RS15800	COG0297	glycogen (starch) synthase activity
AL549_RS15800	COG0438	transferase activity, transferring glycosyl groups
AL549_RS15805	COG0438	transferase activity, transferring glycosyl groups
AL549_RS15830	COG1596	polysaccharide export
AL549_RS15845	COG1115	amino acid carrier protein
AL549_RS15850	COG1132	(ABC) transporter
AL549_RS15855	COG1132	(ABC) transporter
AL549_RS15870	COG0783	Belongs to the Dps family
AL549_RS15885	COG0814	amino acid
AL549_RS15890	COG1597	lipid kinase activity
AL549_RS15900	COG4667	esterase of the alpha-beta hydrolase superfamily
AL549_RS15905	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL549_RS15920	COG0583	DNA-binding transcription factor activity
AL549_RS15925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL549_RS15930	COG1328	CTP reductase activity
AL549_RS15935	COG3300	MHYT domain
AL549_RS15935	COG5001	Diguanylate cyclase
AL549_RS15950	COG2199	diguanylate cyclase activity
AL549_RS15950	COG2200	EAL domain
AL549_RS15955	COG3706	GGDEF domain
AL549_RS15965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL549_RS15965	COG4191	Histidine kinase
AL549_RS15970	COG0471	metal ion transport
AL549_RS15985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL549_RS15990	COG3283	Transcriptional regulator of aromatic amino acids metabolism
AL549_RS15995	COG3768	UPF0283 membrane protein
AL549_RS16000	COG3106	COG3106 Predicted ATPase
AL549_RS16015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL549_RS16025	COG2205	protein histidine kinase activity
AL549_RS16025	COG0784	Response regulator, receiver
AL549_RS16035	COG0494	nUDIX hydrolase
AL549_RS16040	COG0814	amino acid
AL549_RS16045	COG1760	l-serine dehydratase
AL549_RS16050	COG2200	EAL domain
AL549_RS16060	COG0720	synthase
AL549_RS16065	COG0840	transmembrane signaling receptor activity
AL549_RS16070	COG0017	Asparaginyl-tRNA synthetase
AL549_RS16080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL549_RS16095	COG3437	response regulator, receiver
AL549_RS16095	COG2770	Histidine kinase
AL549_RS16100	COG1448	Aminotransferase
AL549_RS16120	COG0840	transmembrane signaling receptor activity
AL549_RS16125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL549_RS16130	COG1846	Transcriptional regulator
AL549_RS16155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL549_RS16170	COG3385	transposase activity
AL549_RS16175	COG2186	Transcriptional regulator
AL549_RS16180	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL549_RS16190	COG0653	protein targeting
AL549_RS16205	COG0366	Alpha amylase catalytic
AL549_RS16215	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL549_RS16225	COG3092	negative regulation of chromosome organization
AL549_RS16230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL549_RS16235	COG0280	phosphate acetyltransferase
AL549_RS16235	COG0857	belongs to the CobB CobQ family
AL549_RS16245	COG0583	DNA-binding transcription factor activity
AL549_RS16270	COG1032	radical SAM domain protein
AL549_RS16290	COG2207	Transcriptional regulator
AL549_RS16310	COG0861	Integral membrane protein TerC family
AL549_RS16315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL549_RS16320	COG0840	transmembrane signaling receptor activity
AL549_RS16325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL549_RS16340	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL549_RS16390	COG0784	Response regulator, receiver
AL549_RS16390	COG2205	protein histidine kinase activity
AL549_RS16400	COG0754	glutathionylspermidine amidase activity
AL549_RS16410	COG3766	membrane
AL549_RS16420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL549_RS16425	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL549_RS16430	COG2885	chlorophyll binding
AL549_RS16435	COG0823	Involved in the tonB-independent uptake of proteins
AL549_RS16450	COG0811	peptide transport
AL549_RS16455	COG0824	Thioesterase
AL549_RS16465	COG4890	Cyd operon protein YbgT
AL549_RS16470	COG1294	oxidase, subunit
AL549_RS16475	COG1271	oxidase subunit
AL549_RS16480	COG2255	four-way junction helicase activity
AL549_RS16485	COG0632	four-way junction helicase activity
AL549_RS16490	COG0840	transmembrane signaling receptor activity
AL549_RS16510	COG4106	trans-aconitate 2-methyltransferase activity
AL549_RS16515	COG0500	methyltransferase
AL549_RS16520	COG4067	protein conserved in archaea
AL549_RS16520	COG0189	ligase activity
AL549_RS16550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL549_RS16555	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL549_RS16565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL549_RS16570	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL549_RS16575	COG0745	RESPONSE REGULATOR receiver
AL549_RS16580	COG3381	protein complex oligomerization
AL549_RS16585	COG1609	Transcriptional regulator
AL549_RS16590	COG3070	regulator of competence-specific genes
AL549_RS16610	COG0297	glycogen (starch) synthase activity
AL549_RS16615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL549_RS16625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL549_RS16635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL549_RS16650	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL549_RS16655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL549_RS16660	COG0542	response to heat
AL549_RS16665	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL549_RS16670	COG1278	Cold shock
AL549_RS16690	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL549_RS16695	COG1199	ATP-dependent helicase activity
AL549_RS16705	COG3923	Primosomal replication protein n
AL549_RS16715	COG0840	transmembrane signaling receptor activity
AL549_RS16720	COG0708	Exodeoxyribonuclease III
AL549_RS16760	COG1882	Formate acetyltransferase
AL549_RS16775	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL549_RS16785	COG3013	Belongs to the UPF0304 family
AL549_RS16790	COG2766	serine protein kinase
AL549_RS16795	COG2718	Belongs to the UPF0229 family
AL549_RS16800	COG2719	SpoVR family
AL549_RS16805	COG2199	diguanylate cyclase activity
AL549_RS16810	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL549_RS16815	COG2835	tetraacyldisaccharide 4'-kinase activity
AL549_RS16820	COG1663	tetraacyldisaccharide 4'-kinase activity
AL549_RS16830	COG0658	competence protein
AL549_RS16830	COG2333	competence protein COMEC
AL549_RS16840	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL549_RS16845	COG1136	(ABC) transporter
AL549_RS16850	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL549_RS16860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL549_RS16875	COG1252	NADH dehydrogenase
AL549_RS16905	COG0537	adenosine 5'-monophosphoramidase activity
AL549_RS16930	COG0517	IMP dehydrogenase activity
AL549_RS16930	COG0617	tRNA 3'-terminal CCA addition
AL549_RS16930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL549_RS16935	COG3706	GGDEF domain
AL549_RS16940	COG1982	Orn Lys Arg decarboxylase major
AL549_RS16945	COG0531	amino acid
AL549_RS16950	COG3710	Transcriptional regulator
AL549_RS16970	COG2199	diguanylate cyclase activity
AL549_RS16970	COG2203	Gaf domain
AL549_RS16975	COG2239	Acts as a magnesium transporter
AL549_RS17010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL549_RS17060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL549_RS17065	COG2226	methyltransferase
AL549_RS17080	COG1785	Belongs to the alkaline phosphatase family
AL549_RS17090	COG0346	lactoylglutathione lyase activity
AL549_RS17100	COG2983	Belongs to the UPF0260 family
AL549_RS17115	COG0745	RESPONSE REGULATOR receiver
AL549_RS17120	COG2205	protein histidine kinase activity
AL549_RS17135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL549_RS17140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL549_RS17150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL549_RS17155	COG2832	Protein of unknown function (DUF454)
AL549_RS17165	COG0745	RESPONSE REGULATOR receiver
AL549_RS17170	COG0583	DNA-binding transcription factor activity
AL549_RS17175	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL549_RS17180	COG1286	toxin biosynthetic process
AL549_RS17185	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL549_RS17190	COG0285	dihydrofolate synthase activity
AL549_RS17195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL549_RS17200	COG0101	tRNA pseudouridine synthase activity
AL549_RS17210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL549_RS17220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL549_RS17225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL549_RS17225	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL549_RS17235	COG3101	peptidyl-lysine hydroxylation
AL549_RS17240	COG2860	membrane
AL549_RS17245	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL549_RS17250	COG2890	protein-(glutamine-N5) methyltransferase activity
AL549_RS17255	COG2840	Smr protein MutS2
AL549_RS17260	COG2062	phosphohistidine phosphatase, SixA
AL549_RS17270	COG1025	Belongs to the peptidase M16 family
AL549_RS17275	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL549_RS17275	COG1024	Enoyl-CoA hydratase
AL549_RS17295	COG2067	long-chain fatty acid transport protein
AL549_RS17300	COG2067	long-chain fatty acid transport protein
AL549_RS17305	COG2853	Lipoprotein
AL549_RS17315	COG3088	subunit of a heme lyase
AL549_RS17315	COG4235	cytochrome complex assembly
AL549_RS17320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL549_RS17325	COG1138	Cytochrome C-type biogenesis protein
AL549_RS17330	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL549_RS17335	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL549_RS17340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL549_RS17345	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL549_RS17350	COG4133	protoheme IX ABC transporter activity
AL549_RS17360	COG0835	chemotaxis
AL549_RS17370	COG1192	Involved in chromosome partitioning
AL549_RS17375	COG2201	protein-glutamate methylesterase activity
AL549_RS17380	COG0784	Response regulator, receiver
AL549_RS17380	COG2198	Histidine kinase
AL549_RS17380	COG0643	Histidine kinase
AL549_RS17385	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL549_RS17420	COG1684	flagellar biosynthetic protein fliR
AL549_RS17425	COG1987	bacterial-type flagellum assembly
AL549_RS17475	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL549_RS17485	COG1677	Flagellar hook-basal body complex protein FliE
AL549_RS17505	COG1516	flagellar protein fliS
AL549_RS17515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL549_RS17520	COG1334	flagellar protein FlaG
AL549_RS17525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL549_RS17530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL549_RS17535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL549_RS17540	COG2837	iron assimilation
AL549_RS17565	COG1393	Belongs to the ArsC family
AL549_RS17585	COG3385	transposase activity
AL549_RS17590	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL549_RS17595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL549_RS17600	COG2716	regulation of RNA biosynthetic process
AL549_RS17605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL549_RS17620	COG4783	chaperone-mediated protein folding
AL549_RS17625	COG1393	Belongs to the ArsC family
AL549_RS17645	COG2233	PERMEase
AL549_RS17650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL549_RS17655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL549_RS17660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL549_RS17665	COG0121	glutamine amidotransferase
AL549_RS17675	COG1960	acyl-CoA dehydrogenase activity
AL549_RS17700	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL549_RS17715	COG0328	RNA-DNA hybrid ribonuclease activity
AL549_RS17720	COG2226	methyltransferase
AL549_RS17725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL549_RS17730	COG0741	lytic transglycosylase activity
AL549_RS17730	COG1388	LysM domain
AL549_RS17740	COG3021	interspecies interaction between organisms
AL549_RS17745	COG0347	Belongs to the P(II) protein family
AL549_RS17755	COG0037	tRNA processing
AL549_RS17760	COG0825	malonyl-CoA metabolic process
AL549_RS17765	COG0587	DNA-directed DNA polymerase activity
AL549_RS17770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL549_RS17775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL549_RS17780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL549_RS17785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL549_RS17795	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL549_RS17800	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL549_RS17810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL549_RS17815	COG0575	Belongs to the CDS family
AL549_RS17820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL549_RS17825	COG0233	cytoplasmic translational termination
AL549_RS17830	COG0528	UMP kinase activity
AL549_RS17835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL549_RS17840	COG0052	Belongs to the universal ribosomal protein uS2 family
AL549_RS17845	COG0024	Methionine aminopeptidase
AL549_RS17850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL549_RS17865	COG3098	single-species biofilm formation
AL549_RS17905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL549_RS17925	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL549_RS17935	COG0254	rRNA binding
AL549_RS17940	COG1720	tRNA m6t6A37 methyltransferase activity
AL549_RS17965	COG0733	neurotransmitter:sodium symporter activity
AL549_RS17980	COG0514	ATP-dependent DNA helicase (RecQ)
AL549_RS17985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL549_RS18000	COG1477	protein flavinylation
AL549_RS18005	COG2871	sodium ion transport
AL549_RS18010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL549_RS18020	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL549_RS18025	COG1805	sodium ion transport
AL549_RS18030	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL549_RS18035	COG0271	Belongs to the BolA IbaG family
AL549_RS18040	COG2813	Specifically methylates the guanine in position
AL549_RS18055	COG2211	Major facilitator Superfamily
AL549_RS18065	COG1595	DNA-templated transcription, initiation
AL549_RS18075	COG3248	Nucleoside-binding outer membrane protein
AL549_RS18080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL549_RS18085	COG0693	protein deglycase activity
AL549_RS18090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL549_RS18095	COG2166	iron-sulfur cluster assembly
AL549_RS18100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL549_RS18105	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL549_RS18125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL549_RS18130	COG1074	ATP-dependent DNA helicase activity
AL549_RS18135	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL549_RS18140	COG3083	sulfuric ester hydrolase activity
AL549_RS18155	COG3141	response to X-ray
AL549_RS18160	COG2171	N-acyltransferase activity
AL549_RS18165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL549_RS18170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL549_RS18175	COG1349	DNA-binding transcription factor activity
AL549_RS18180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL549_RS18195	COG0569	domain protein
AL549_RS18195	COG0189	ligase activity
AL549_RS18215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL549_RS18225	COG0840	transmembrane signaling receptor activity
AL549_RS18230	COG2017	converts alpha-aldose to the beta-anomer
AL549_RS18245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL549_RS18250	COG1609	Transcriptional regulator
AL549_RS18260	COG3250	beta-galactosidase activity
AL549_RS18265	COG2731	YhcH YjgK YiaL family protein
AL549_RS18270	COG0531	amino acid
AL549_RS18275	COG0531	amino acid
AL549_RS18280	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AL549_RS18280	COG3408	Glycogen debranching enzyme
AL549_RS18290	COG0583	DNA-binding transcription factor activity
AL549_RS18295	COG2059	Chromate
AL549_RS18345	COG4964	Belongs to the GSP D family
AL549_RS18380	COG1022	Amp-dependent synthetase and ligase
AL549_RS18390	COG0583	DNA-binding transcription factor activity
AL549_RS18395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL549_RS18410	COG3447	MASE1 domain protein
AL549_RS18410	COG5001	Diguanylate cyclase
AL549_RS18410	COG5002	protein histidine kinase activity
AL549_RS18415	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL549_RS18425	COG0560	Phosphoserine phosphatase
AL549_RS18435	COG0813	purine-nucleoside phosphorylase activity
AL549_RS18440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL549_RS18445	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL549_RS18450	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL549_RS18455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL549_RS18460	COG0084	hydrolase, TatD family'
AL549_RS18470	COG3706	GGDEF domain
AL549_RS18480	COG0456	acetyltransferase
AL549_RS18490	COG3153	acetyltransferase
AL549_RS18495	COG3154	lipid carrier protein
AL549_RS18505	COG0826	peptidase U32
AL549_RS18510	COG0826	peptidase U32
AL549_RS18515	COG0534	Mate efflux family protein
AL549_RS18530	COG1185	polyribonucleotide nucleotidyltransferase activity
AL549_RS18555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL549_RS18560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL549_RS18565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL549_RS18575	COG0195	Participates in both transcription termination and antitermination
AL549_RS18580	COG0779	Required for maturation of 30S ribosomal subunits
AL549_RS18595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL549_RS18600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL549_RS18605	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL549_RS18610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL549_RS18615	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL549_RS18620	COG1534	Rna-binding protein
AL549_RS18640	COG2027	D-alanyl-D-alanine carboxypeptidase
AL549_RS18645	COG2832	Protein of unknown function (DUF454)
AL549_RS18650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL549_RS18655	COG0739	heme binding
AL549_RS18670	COG0316	Belongs to the HesB IscA family
AL549_RS18680	COG0628	permease
AL549_RS18685	COG2813	Specifically methylates the guanine in position
AL549_RS18690	COG0784	Response regulator, receiver
AL549_RS18690	COG2205	protein histidine kinase activity
AL549_RS18700	COG0601	transmembrane transport
AL549_RS18705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL549_RS18710	COG0444	Belongs to the ABC transporter superfamily
AL549_RS18715	COG4608	Belongs to the ABC transporter superfamily
AL549_RS18725	COG2971	BadF BadG BcrA BcrD
AL549_RS18740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL549_RS18755	COG1840	ABC-type Fe3 transport system, periplasmic component
AL549_RS18760	COG0004	ammonium transporteR
AL549_RS18765	COG0347	Belongs to the P(II) protein family
AL549_RS18770	COG3112	Uncharacterised protein family (UPF0231)
AL549_RS18775	COG3835	regulator
AL549_RS18780	COG2610	gluconate transmembrane transporter activity
AL549_RS18785	COG1929	Belongs to the glycerate kinase type-1 family
AL549_RS18790	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL549_RS18795	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL549_RS18800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL549_RS18805	COG1643	Atp-dependent helicase
AL549_RS18815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL549_RS18830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL549_RS18835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL549_RS18845	COG0842	Transport permease protein
AL549_RS18850	COG1131	(ABC) transporter
AL549_RS18855	COG0659	secondary active sulfate transmembrane transporter activity
AL549_RS18860	COG0288	reversible hydration of carbon dioxide
AL549_RS18875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL549_RS18880	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL549_RS18885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL549_RS18890	COG2186	Transcriptional regulator
AL549_RS18895	COG3023	N-Acetylmuramoyl-L-alanine amidase
AL549_RS18910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL549_RS18915	COG1459	type II secretion system
AL549_RS18935	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL549_RS18940	COG0335	large ribosomal subunit rRNA binding
AL549_RS18945	COG0336	Belongs to the RNA methyltransferase TrmD family
AL549_RS18950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL549_RS18955	COG0228	four-way junction DNA binding
AL549_RS18960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL549_RS18965	COG4137	Cytochrome C assembly protein
AL549_RS18970	COG4536	flavin adenine dinucleotide binding
AL549_RS18975	COG1854	S-ribosylhomocysteine lyase activity
AL549_RS18985	COG2918	glutathione biosynthetic process
AL549_RS18990	COG0612	Peptidase, M16
AL549_RS18995	COG1238	metal cluster binding
AL549_RS19005	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL549_RS19010	COG0511	ligase activity, forming carbon-carbon bonds
AL549_RS19010	COG5016	pyruvate
AL549_RS19015	COG3630	sodium ion export across plasma membrane
AL549_RS19060	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AL549_RS19065	COG0527	aspartate kinase activity
AL549_RS19070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL549_RS19075	COG2137	regulation of response to DNA damage stimulus
AL549_RS19080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL549_RS19090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL549_RS19095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL549_RS19100	COG1388	LysM domain
AL549_RS19100	COG4942	peptidase
AL549_RS19105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL549_RS19120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL549_RS19130	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL549_RS19140	COG0504	CTP synthase activity
AL549_RS19145	COG3956	TIGRFAM MazG family protein
AL549_RS19150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL549_RS19155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL549_RS19160	COG2205	protein histidine kinase activity
AL549_RS19160	COG3437	response regulator, receiver
AL549_RS19160	COG3850	Histidine kinase
AL549_RS19160	COG4999	Histidine kinase
AL549_RS19180	COG0736	holo-[acyl-carrier-protein] synthase activity
AL549_RS19185	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL549_RS19190	COG1381	Involved in DNA repair and RecF pathway recombination
AL549_RS19195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL549_RS19210	COG0481	GTPase activity
AL549_RS19215	COG3086	response to oxidative stress
AL549_RS19230	COG1595	DNA-templated transcription, initiation
AL549_RS19235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL549_RS19250	COG0354	folic acid binding
AL549_RS19265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL549_RS19270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL549_RS19275	COG3079	Belongs to the UPF0149 family
AL549_RS19280	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL549_RS19290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL549_RS19300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL549_RS19315	COG1279	arginine transmembrane transporter activity
AL549_RS19320	COG0668	transmembrane transport
AL549_RS19325	COG0191	fructose-bisphosphate aldolase activity
AL549_RS19330	COG0126	phosphoglycerate kinase activity
AL549_RS19350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL549_RS19360	COG3091	SprT-like family
AL549_RS19365	COG2356	endonuclease I
AL549_RS19375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL549_RS19385	COG1678	Uncharacterized ACR, COG1678
AL549_RS19390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL549_RS19405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL549_RS19410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL549_RS19415	COG0762	integral membrane protein
AL549_RS19420	COG1872	DUF167
AL549_RS19430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL549_RS19435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL549_RS19445	COG2066	Belongs to the glutaminase family
AL549_RS19450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL549_RS19460	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL549_RS19580	COG3437	response regulator, receiver
AL549_RS19590	COG1609	Transcriptional regulator
AL549_RS19600	COG1486	melibiose metabolic process
AL549_RS19605	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL549_RS19615	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL549_RS19620	COG0726	polysaccharide deacetylase
AL549_RS19635	COG0795	lipopolysaccharide-transporting ATPase activity
AL549_RS19640	COG0795	lipopolysaccharide-transporting ATPase activity
AL549_RS19645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL549_RS19650	COG2927	DNA polymerase III (CHI subunit)
AL549_RS19655	COG0525	valine-tRNA ligase activity
AL549_RS19665	COG4269	membrane
AL549_RS19675	COG0456	acetyltransferase
AL549_RS19710	COG0251	oxidation-reduction process
AL549_RS19715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL549_RS19730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL549_RS19735	COG0312	modulator of DNA gyrase
AL549_RS19740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL549_RS19745	COG3164	Protein of unknown function
AL549_RS19755	COG0424	maF-like protein
AL549_RS19760	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL549_RS19765	COG1792	Involved in formation and maintenance of cell shape
AL549_RS19770	COG1077	Cell shape determining protein MreB Mrl
AL549_RS19800	COG2165	general secretion pathway protein
AL549_RS19805	COG2165	general secretion pathway protein
AL549_RS19815	COG1459	type II secretion system
AL549_RS19820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL549_RS19830	COG3267	Type II secretory pathway component ExeA
AL549_RS19830	COG3409	Peptidoglycan-binding domain 1 protein
AL549_RS19855	COG2200	EAL domain
AL549_RS19855	COG2199	diguanylate cyclase activity
AL549_RS19875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL549_RS19885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL549_RS19895	COG0527	aspartate kinase activity
AL549_RS19900	COG1410	methionine synthase
AL549_RS19900	COG0646	methionine synthase
AL549_RS20010	COG0735	belongs to the Fur family
AL549_RS20025	COG0432	Pfam Uncharacterised protein family UPF0047
AL549_RS20035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL549_RS20050	COG0359	binds to the 23S rRNA
AL549_RS20060	COG2965	DNA replication, synthesis of RNA primer
AL549_RS20065	COG0360	Binds together with S18 to 16S ribosomal RNA
AL549_RS20070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL549_RS20075	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL549_RS20085	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL549_RS20090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL549_RS20120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL549_RS20135	COG0165	Argininosuccinate lyase
AL549_RS20135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL549_RS20140	COG0137	argininosuccinate synthase activity
AL549_RS20160	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL549_RS20170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL549_RS20175	COG0527	aspartate kinase activity
AL549_RS20175	COG0460	homoserine dehydrogenase
AL549_RS20180	COG0626	cystathionine gamma-synthase activity
AL549_RS20185	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AL549_RS20190	COG0281	malic enzyme
AL549_RS20195	COG0254	rRNA binding
AL549_RS20200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL549_RS20205	COG1609	Transcriptional regulator
AL549_RS20215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL549_RS20220	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL549_RS20225	COG1575	Belongs to the MenA family. Type 1 subfamily
AL549_RS20235	COG3074	FtsZ-dependent cytokinesis
AL549_RS20240	COG1494	fructose-1,6-bisphosphatase
AL549_RS20265	COG0149	triose-phosphate isomerase activity
AL549_RS20270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL549_RS20280	COG2906	2 iron, 2 sulfur cluster binding
AL549_RS20290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL549_RS20295	COG0049	tRNA binding
AL549_RS20300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL549_RS20305	COG2168	tRNA wobble position uridine thiolation
AL549_RS20315	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL549_RS20320	COG2964	Protein conserved in bacteria
AL549_RS20325	COG0545	Peptidyl-prolyl cis-trans isomerase
AL549_RS20335	COG2900	Belongs to the SlyX family
AL549_RS20345	COG1047	Peptidyl-prolyl cis-trans
AL549_RS20360	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL549_RS20365	COG0488	(ABC) transporter
AL549_RS20375	COG0429	hydrolase of the alpha beta-hydrolase fold
AL549_RS20380	COG3089	Belongs to the UPF0270 family
AL549_RS20385	COG3954	Phosphoribulokinase
AL549_RS20390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL549_RS20410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL549_RS20440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL549_RS20445	COG0557	exoribonuclease II activity
AL549_RS20450	COG0402	S-adenosylhomocysteine deaminase activity
AL549_RS20455	COG1959	2 iron, 2 sulfur cluster binding
AL549_RS20465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL549_RS20470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL549_RS20475	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL549_RS20480	COG0330	HflC and HflK could
AL549_RS20485	COG0330	HflC and HflK could
AL549_RS20490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL549_RS20495	COG1923	regulation of RNA biosynthetic process
AL549_RS20510	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL549_RS20515	COG0802	atpase or kinase
AL549_RS20520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL549_RS20580	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL549_RS20585	COG1162	GTPase activity
AL549_RS20590	COG0688	phosphatidylethanolamine metabolic process
AL549_RS20595	COG0471	metal ion transport
AL549_RS20605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL549_RS20615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL549_RS20620	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL549_RS20625	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL549_RS20630	COG1045	serine acetyltransferase
AL549_RS20635	COG4942	peptidase
AL549_RS20655	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL549_RS20660	COG1053	succinate dehydrogenase
AL549_RS20665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL549_RS20670	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL549_RS20675	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL549_RS20685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL549_RS20690	COG1509	lysine 2,3-aminomutase activity
AL549_RS20695	COG1285	pathogenesis
AL549_RS20705	COG0459	protein refolding
AL549_RS20710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL549_RS20715	COG0534	Mate efflux family protein
AL549_RS20720	COG0205	6-phosphofructokinase activity
AL549_RS20730	COG3678	ATP-independent chaperone mediated protein folding
AL549_RS20735	COG0745	RESPONSE REGULATOR receiver
AL549_RS20740	COG2205	protein histidine kinase activity
AL549_RS20750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL549_RS20760	COG1027	Aspartate ammonia-lyase
AL549_RS20765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL549_RS20780	COG2095	MarC family integral membrane protein
AL549_RS20790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL549_RS20810	COG0784	Response regulator, receiver
AL549_RS20810	COG2198	Histidine kinase
AL549_RS20810	COG2205	protein histidine kinase activity
AL549_RS20815	COG2814	Major facilitator Superfamily
AL549_RS20830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL549_RS20835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL549_RS20840	COG0511	ligase activity, forming carbon-carbon bonds
AL549_RS20845	COG0439	Biotin carboxylase
AL549_RS20850	COG2264	protein methyltransferase activity
AL549_RS20860	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL549_RS20865	COG0840	transmembrane signaling receptor activity
AL549_RS20870	COG0789	Transcriptional regulator
AL549_RS20880	COG0138	bifunctional purine biosynthesis protein purh
AL549_RS20885	COG0151	Belongs to the GarS family
AL549_RS20900	COG1253	flavin adenine dinucleotide binding
AL549_RS20905	COG3068	Protein conserved in bacteria
AL549_RS20910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL549_RS20915	COG1573	uracil-dna glycosylase
AL549_RS20920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL549_RS20940	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL549_RS20945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL549_RS20950	COG0085	RNA polymerase activity
AL549_RS20955	COG0222	ribosome binding
AL549_RS20960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL549_RS20965	COG0081	regulation of translation
AL549_RS20980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL549_RS20985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL549_RS21020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL549_RS21030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL549_RS21105	COG4206	TonB-dependent receptor
AL549_RS21110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL549_RS21125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL549_RS21135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL549_RS21165	COG1580	Controls the rotational direction of flagella during chemotaxis
AL549_RS21175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL549_RS21185	COG2177	Part of the ABC transporter FtsEX involved in
AL549_RS21190	COG2884	Cell division ATP-binding protein ftsE
AL549_RS21195	COG0552	protein localization to endoplasmic reticulum
AL549_RS21200	COG0742	ribosomal rna small subunit methyltransferase
AL549_RS21210	COG2095	MarC family integral membrane protein
AL549_RS21255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL549_RS21260	COG0640	Transcriptional regulator
AL549_RS21265	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL549_RS21270	COG1280	lysine exporter protein (LysE YggA)
AL549_RS21275	COG2267	carboxylic ester hydrolase activity
AL549_RS21280	COG0561	phosphatase activity
AL549_RS21295	COG3148	PFAM DTW domain containing protein
AL549_RS21300	COG2200	EAL domain
AL549_RS21300	COG3287	FIST C domain
AL549_RS21300	COG2199	diguanylate cyclase activity
AL549_RS21305	COG1011	Hydrolase
AL549_RS21310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL549_RS21320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL549_RS21325	COG0019	diaminopimelate decarboxylase activity
AL549_RS21335	COG1965	Belongs to the frataxin family
AL549_RS21340	COG3072	Adenylate cyclase
AL549_RS21345	COG0181	hydroxymethylbilane synthase activity
AL549_RS21355	COG2959	enzyme of heme biosynthesis
AL549_RS21365	COG2081	HI0933 family
AL549_RS21375	COG1528	Iron-storage protein
AL549_RS21380	COG0589	response to stress
AL549_RS21400	COG5002	protein histidine kinase activity
AL549_RS21400	COG5001	Diguanylate cyclase
AL549_RS21405	COG1522	sequence-specific DNA binding
AL549_RS21415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL549_RS21420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL549_RS21440	COG0800	Aldolase
AL549_RS21450	COG3265	gluconokinase activity
AL549_RS21455	COG0129	dihydroxy-acid dehydratase activity
AL549_RS21460	COG1609	Transcriptional regulator
AL549_RS21465	COG0745	RESPONSE REGULATOR receiver
AL549_RS21475	COG2815	serine threonine protein kinase
AL549_RS21475	COG0515	serine threonine protein kinase
AL549_RS21510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL549_RS21515	COG0601	transmembrane transport
AL549_RS21520	COG4166	transmembrane transport
AL549_RS21525	COG4172	Belongs to the ABC transporter superfamily
AL549_RS21565	COG1309	transcriptional regulator
AL549_RS21570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL549_RS21575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL549_RS21580	COG2960	long-chain fatty acid transporting porin activity
AL549_RS21585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL549_RS21635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL549_RS21640	COG1739	Uncharacterized protein family UPF0029
AL549_RS21650	COG0183	Belongs to the thiolase family
AL549_RS21655	COG0604	alcohol dehydrogenase
AL549_RS21670	COG0425	Belongs to the sulfur carrier protein TusA family
AL549_RS21680	COG2119	membrane
AL549_RS21685	COG0752	glycyl-tRNA synthetase alpha subunit
AL549_RS21700	COG3977	Valine--pyruvate aminotransferase
AL549_RS21710	COG0071	Belongs to the small heat shock protein (HSP20) family
AL549_RS21715	COG0187	DNA topoisomerase II activity
AL549_RS21725	COG0592	DNA-directed DNA polymerase activity
AL549_RS21745	COG1126	abc transporter atp-binding protein
AL549_RS21750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AL549_RS21755	COG0594	ribonuclease P activity
AL549_RS21765	COG0706	membrane insertase activity
AL549_RS21775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL549_RS21790	COG0357	Ribosomal RNA small subunit methyltransferase G
AL549_RS21795	COG1192	Involved in chromosome partitioning
AL549_RS21800	COG1475	DNA binding
AL549_RS21805	COG3312	ion transport
AL549_RS21810	COG0356	it plays a direct role in the translocation of protons across the membrane
AL549_RS21820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL549_RS21825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL549_RS21830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL549_RS21835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL549_RS21840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL549_RS21845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL549_RS21855	COG0765	amino acid transport
AL549_RS21865	COG2814	Major facilitator Superfamily
AL549_RS21870	COG0583	DNA-binding transcription factor activity
AL549_RS21880	COG0129	dihydroxy-acid dehydratase activity
AL549_RS21885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL549_RS21890	COG3978	acetolactate synthase activity
AL549_RS21900	COG0606	chelatase, subunit chli
AL549_RS21910	COG0204	Acyl-transferase
AL549_RS21915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL549_RS21920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL549_RS21930	COG3084	Protein conserved in bacteria
AL549_RS21935	COG4326	sporulation control protein
AL549_RS21940	COG1272	protein, Hemolysin III
AL549_RS21945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL549_RS21950	COG0569	domain protein
AL549_RS21965	COG0242	peptide deformylase activity
AL549_RS21975	COG0758	DNA mediated transformation
AL549_RS21980	COG2922	Belongs to the Smg family
AL549_RS21985	COG0551	DNA topoisomerase type I activity
AL549_RS21995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL549_RS22000	COG0009	L-threonylcarbamoyladenylate synthase
AL549_RS22005	COG0408	coproporphyrinogen oxidase activity
AL549_RS22010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL549_RS22020	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL549_RS22065	COG2132	Multicopper oxidase
AL549_RS22070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL549_RS22075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL549_RS22085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL549_RS22095	COG2022	thiamine diphosphate biosynthetic process
AL549_RS22105	COG0006	proline dipeptidase activity
AL549_RS22105	COG0006	proline dipeptidase activity
AL549_RS22145	COG0210	DNA helicase
AL549_RS22155	COG1280	lysine exporter protein (LysE YggA)
AL549_RS22165	COG2962	Rard protein
AL549_RS22170	COG0514	ATP-dependent DNA helicase (RecQ)
AL549_RS22185	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL549_RS22190	COG0248	Ppx GppA phosphatase
AL549_RS22200	COG3118	belongs to the thioredoxin family
AL549_RS22315	COG1322	Protein conserved in bacteria
AL549_RS22320	COG2226	methyltransferase
AL549_RS22325	COG3165	ubiquinone biosynthetic process from chorismate
AL549_RS22335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL549_RS22340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL549_RS22345	COG0805	protein transport
AL549_RS22350	COG0084	hydrolase, TatD family'
AL549_RS22360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL549_RS22360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL549_RS22380	COG3078	GTPase activator activity
AL549_RS22395	COG5001	Diguanylate cyclase
AL549_RS22395	COG3300	MHYT domain
AL549_RS22400	COG2204	response regulator
AL549_RS22405	COG3852	Histidine kinase
AL549_RS22415	COG0174	glutamine synthetase
AL549_RS22425	COG1217	gtp-binding protein TYPA
AL549_RS22440	COG1295	ribonuclease BN
AL549_RS22445	COG1490	D-aminoacyl-tRNA deacylase activity
AL549_RS22450	COG0456	acetyltransferase
AL549_RS22465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL549_RS22470	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL549_RS22475	COG3031	protein transport across the cell outer membrane
AL549_RS22485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL549_RS22490	COG1459	type II secretion system
AL549_RS22495	COG2165	general secretion pathway protein
AL549_RS22500	COG2165	general secretion pathway protein
AL549_RS22505	COG2165	general secretion pathway protein
AL549_RS22510	COG4795	General secretion pathway protein
AL549_RS22515	COG3156	type II secretion system protein K
AL549_RS22520	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL549_RS22525	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL549_RS22535	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL549_RS22540	COG0494	nUDIX hydrolase
AL549_RS22545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL549_RS22545	COG0316	Belongs to the HesB IscA family
AL549_RS22550	COG1040	competence protein
AL549_RS22555	COG0596	Alpha beta hydrolase
AL549_RS22565	COG2183	response to ionizing radiation
AL549_RS22585	COG2233	PERMEase
AL549_RS22590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL549_RS22595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL549_RS22600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL549_RS22605	COG1758	RNA polymerase activity
AL549_RS22610	COG0194	GDP metabolic process
AL549_RS22625	COG0848	biopolymer transport protein
AL549_RS22630	COG0811	peptide transport
AL549_RS22635	COG0811	peptide transport
AL549_RS22645	COG4206	TonB-dependent receptor
AL549_RS22650	COG4174	ABC transporter (Permease)
AL549_RS22655	COG4239	(ABC) transporter, permease
AL549_RS22660	COG0747	negative chemotaxis
AL549_RS22665	COG0444	Belongs to the ABC transporter superfamily
AL549_RS22670	COG4608	Belongs to the ABC transporter superfamily
AL549_RS22700	COG1561	YicC-like family, N-terminal region
AL549_RS22705	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL549_RS22715	COG1560	Kdo2-lipid A biosynthetic process
AL549_RS22720	COG1309	transcriptional regulator
AL549_RS22725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL549_RS22735	COG2003	Belongs to the UPF0758 family
AL549_RS22740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL549_RS22745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL549_RS22765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL549_RS22770	COG0859	PFAM glycosyl transferase family 9
AL549_RS22775	COG0463	Glycosyl transferase, family 2
AL549_RS22780	COG0859	PFAM glycosyl transferase family 9
AL549_RS22785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL549_RS22790	COG3642	lipopolysaccharide core region biosynthetic process
AL549_RS22795	COG3083	sulfuric ester hydrolase activity
AL549_RS22810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL549_RS22815	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL549_RS22820	COG2089	acid synthase
AL549_RS22835	COG0673	inositol 2-dehydrogenase activity
AL549_RS22845	COG1083	cytidylyl-transferase
AL549_RS22850	COG1028	Short-chain dehydrogenase reductase Sdr
AL549_RS22865	COG0318	PFAM AMP-dependent synthetase and ligase
AL549_RS22895	COG1519	Transferase
AL549_RS22900	COG0859	PFAM glycosyl transferase family 9
AL549_RS22905	COG1560	Kdo2-lipid A biosynthetic process
AL549_RS22910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL549_RS22915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL549_RS22960	COG1596	polysaccharide export
AL549_RS22975	COG3206	protein involved in exopolysaccharide biosynthesis
AL549_RS22975	COG0489	protein tyrosine kinase activity
AL549_RS22990	COG3475	LICD family
AL549_RS22995	COG3475	LICD family
AL549_RS23020	COG1086	Polysaccharide biosynthesis protein
AL549_RS23050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL549_RS23075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL549_RS23115	COG0088	Forms part of the polypeptide exit tunnel
AL549_RS23120	COG0089	rRNA binding
AL549_RS23125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL549_RS23130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL549_RS23140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL549_RS23145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL549_RS23150	COG0255	Belongs to the universal ribosomal protein uL29 family
AL549_RS23155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL549_RS23160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL549_RS23165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL549_RS23170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL549_RS23175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL549_RS23180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL549_RS23185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL549_RS23190	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL549_RS23195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL549_RS23200	COG1841	ribosomal large subunit assembly
AL549_RS23205	COG0200	Binds to the 23S rRNA
AL549_RS23210	COG0201	protein transport
AL549_RS23215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL549_RS23220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL549_RS23225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL549_RS23230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL549_RS23235	COG0202	RNA polymerase activity
AL549_RS23240	COG0203	ribosomal protein L17
AL549_RS23250	COG0545	Peptidyl-prolyl cis-trans isomerase
AL549_RS23255	COG3061	Opacity-associated protein A
AL549_RS23255	COG3266	domain, Protein
AL549_RS23265	COG2153	protein acetylation
AL549_RS23275	COG0737	Belongs to the 5'-nucleotidase family
AL549_RS23280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL549_RS23280	COG1648	precorrin-2 dehydrogenase activity
AL549_RS23285	COG0175	sulfate reduction
AL549_RS23290	COG2895	sulfate adenylyltransferase (ATP) activity
AL549_RS23295	COG0471	metal ion transport
AL549_RS23295	COG3273	potassium ion transport
AL549_RS23300	COG0529	Catalyzes the synthesis of activated sulfate
AL549_RS23320	COG0577	efflux transmembrane transporter activity
AL549_RS23320	COG1136	(ABC) transporter
AL549_RS23335	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL549_RS23350	COG0729	surface antigen
AL549_RS23355	COG2911	Protein conserved in bacteria
AL549_RS23360	COG2105	PFAM AIG2 family protein
AL549_RS23370	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL549_RS23375	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL549_RS23380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL549_RS23385	COG0163	prenyltransferase activity
AL549_RS23390	COG4143	(ABC) transporter
AL549_RS23395	COG1178	ABC-type Fe3 transport system permease component
AL549_RS23400	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL549_RS23405	COG3028	Belongs to the UPF0307 family
AL549_RS23410	COG0312	modulator of DNA gyrase
AL549_RS23415	COG2239	Acts as a magnesium transporter
AL549_RS23420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL549_RS23425	COG1660	Displays ATPase and GTPase activities
AL549_RS23430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL549_RS23435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL549_RS23445	COG1137	ATPase activity
AL549_RS23450	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL549_RS23460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AL549_RS23465	COG0517	IMP dehydrogenase activity
AL549_RS23465	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL549_RS23475	COG1127	ABC transporter
AL549_RS23480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL549_RS23485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL549_RS23490	COG2854	intermembrane phospholipid transfer
AL549_RS23500	COG5007	Belongs to the BolA IbaG family
AL549_RS23510	COG0204	Acyl-transferase
AL549_RS23515	COG0589	response to stress
AL549_RS23525	COG2358	TRAP transporter, solute receptor (TAXI family
AL549_RS23530	COG1438	arginine binding
AL549_RS23535	COG0039	L-malate dehydrogenase activity
AL549_RS23540	COG0142	geranyltranstransferase activity
AL549_RS23545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL549_RS23550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL549_RS23555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL549_RS23560	COG2966	Psort location CytoplasmicMembrane, score
AL549_RS23565	COG3610	response to peptide
AL549_RS23580	COG2967	ApaG domain
AL549_RS23585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL549_RS23590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL549_RS23625	COG0473	3-isopropylmalate dehydrogenase activity
AL549_RS23630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL549_RS23655	COG1022	Amp-dependent synthetase and ligase
AL549_RS23660	COG0028	Belongs to the TPP enzyme family
AL549_RS23665	COG0440	acetolactate synthase activity
AL549_RS23670	COG3706	GGDEF domain
AL549_RS23685	COG1349	DNA-binding transcription factor activity
AL549_RS23695	COG3722	fumarate hydratase activity
AL549_RS23705	COG2213	PTS system mannitol-specific
AL549_RS23705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL549_RS23710	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL549_RS23740	COG1610	YqeY-like protein
AL549_RS23745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL549_RS23750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL549_RS23755	COG0596	Alpha beta hydrolase
AL549_RS23765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL549_RS23770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL549_RS23775	COG1968	undecaprenyl-diphosphatase activity
AL549_RS23780	COG0617	tRNA 3'-terminal CCA addition
AL549_RS23785	COG3267	Type II secretory pathway component ExeA
AL549_RS23785	COG3409	Peptidoglycan-binding domain 1 protein
AL549_RS23790	COG4991	sh3 domain protein
AL549_RS23795	COG0306	phosphate transporter