locus-tag	class	description
VV1_RS00025	COG0628	permease
VV1_RS00030	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VV1_RS00030	COG3264	Mechanosensitive ion channel
VV1_RS00045	COG1127	ABC transporter
VV1_RS00050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VV1_RS00060	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VV1_RS00065	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VV1_RS00080	COG1555	photosystem II stabilization
VV1_RS00085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VV1_RS00090	COG0776	regulation of translation
VV1_RS00095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VV1_RS00100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VV1_RS00115	COG4191	Histidine kinase
VV1_RS00120	COG2204	response regulator
VV1_RS00130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VV1_RS00135	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VV1_RS00140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VV1_RS00145	COG3842	ATPase activity
VV1_RS00155	COG1175	transmembrane transport
VV1_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV1_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV1_RS00230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VV1_RS00240	COG1216	Glycosyl transferase, family 2
VV1_RS00245	COG2986	histidine ammonia-lyase
VV1_RS00270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VV1_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
VV1_RS00300	COG1695	Transcriptional regulator
VV1_RS00560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VV1_RS00575	COG5002	protein histidine kinase activity
VV1_RS00580	COG0745	RESPONSE REGULATOR receiver
VV1_RS00590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VV1_RS00600	COG2951	lytic endotransglycosylase activity
VV1_RS00610	COG0850	regulation of cytokinetic process
VV1_RS00620	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VV1_RS00625	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VV1_RS00630	COG0318	PFAM AMP-dependent synthetase and ligase
VV1_RS00635	COG0596	Alpha beta hydrolase
VV1_RS00650	COG1214	PFAM Peptidase M22, glycoprotease
VV1_RS00655	COG1199	ATP-dependent helicase activity
VV1_RS00665	COG0788	formyltetrahydrofolate deformylase activity
VV1_RS00670	COG3102	Protein conserved in bacteria
VV1_RS00690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VV1_RS00695	COG1918	ferrous iron import across plasma membrane
VV1_RS00705	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VV1_RS00710	COG1121	(ABC) transporter
VV1_RS00715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VV1_RS00730	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV1_RS00735	COG0567	Dehydrogenase, E1 component
VV1_RS00745	COG1053	succinate dehydrogenase
VV1_RS00750	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VV1_RS00755	COG2009	succinate dehydrogenase
VV1_RS00765	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VV1_RS00775	COG0446	pyridine nucleotide-disulphide oxidoreductase
VV1_RS00785	COG0251	oxidation-reduction process
VV1_RS00790	COG2964	Protein conserved in bacteria
VV1_RS00795	COG0033	Phosphoglucomutase
VV1_RS00800	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VV1_RS00805	COG0596	Alpha beta hydrolase
VV1_RS00815	COG0716	FMN binding
VV1_RS00830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV1_RS00835	COG1263	PTS System
VV1_RS00835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV1_RS00835	COG2190	(PTS) system
VV1_RS00840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VV1_RS00845	COG1846	Transcriptional regulator
VV1_RS00845	COG1940	carbohydrate kinase activity
VV1_RS00850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VV1_RS00850	COG4651	solute:proton antiporter activity
VV1_RS00855	COG0367	asparagine synthase
VV1_RS00865	COG3104	oligopeptide transport
VV1_RS00870	COG0840	transmembrane signaling receptor activity
VV1_RS00890	COG3710	Transcriptional regulator
VV1_RS00910	COG0622	Phosphoesterase
VV1_RS00935	COG1090	epimerase
VV1_RS00940	COG0300	oxidoreductase activity
VV1_RS00945	COG3118	belongs to the thioredoxin family
VV1_RS00950	COG0330	HflC and HflK could
VV1_RS00980	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VV1_RS00985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VV1_RS00990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV1_RS00995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VV1_RS01000	COG2190	(PTS) system
VV1_RS01005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV1_RS01010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV1_RS01020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV1_RS01025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV1_RS01035	COG1705	Flagellar rod assembly protein muramidase FlgJ
VV1_RS01035	COG3951	Flagellar rod assembly protein muramidase FlgJ
VV1_RS01040	COG1706	bacterial-type flagellum-dependent cell motility
VV1_RS01055	COG4787	bacterial-type flagellum-dependent cell motility
VV1_RS01060	COG1749	Flagellar hook protein flgE
VV1_RS01075	COG1815	bacterial-type flagellum-dependent cell motility
VV1_RS01080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VV1_RS01085	COG0784	Response regulator, receiver
VV1_RS01085	COG0835	chemotaxis
VV1_RS01145	COG2608	mercury ion transmembrane transporter activity
VV1_RS01145	COG2217	Heavy metal translocating P-type atpase
VV1_RS01160	COG3735	TraB family
VV1_RS01175	COG2840	Smr protein MutS2
VV1_RS01180	COG1187	pseudouridine synthase activity
VV1_RS01195	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VV1_RS01200	COG2912	Transglutaminase-like superfamily
VV1_RS01210	COG2890	protein-(glutamine-N5) methyltransferase activity
VV1_RS01215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VV1_RS01230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VV1_RS01235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VV1_RS01240	COG0193	aminoacyl-tRNA hydrolase activity
VV1_RS01325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV1_RS01335	COG1702	phosphate starvation-inducible protein PhoH
VV1_RS01345	COG4535	Mg2 and Co2 transporter CorC
VV1_RS01355	COG2888	peptidyl-tyrosine sulfation
VV1_RS01365	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VV1_RS01370	COG1466	dna polymerase III delta subunit
VV1_RS01375	COG0799	negative regulation of ribosome biogenesis
VV1_RS01380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VV1_RS01385	COG0768	penicillin binding
VV1_RS01390	COG0772	Belongs to the SEDS family
VV1_RS01395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VV1_RS01400	COG1686	Belongs to the peptidase S11 family
VV1_RS01405	COG2921	Belongs to the UPF0250 family
VV1_RS01415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VV1_RS01425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VV1_RS01435	COG0366	Alpha amylase catalytic
VV1_RS01440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV1_RS01440	COG1263	PTS System
VV1_RS01450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VV1_RS01460	COG2011	ABC-type metal ion transport system permease component
VV1_RS01465	COG1464	Belongs to the NlpA lipoprotein family
VV1_RS01470	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VV1_RS01495	COG1611	Belongs to the LOG family
VV1_RS01515	COG2363	Small membrane protein
VV1_RS01525	COG0583	DNA-binding transcription factor activity
VV1_RS01540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VV1_RS01545	COG1722	exodeoxyribonuclease VII activity
VV1_RS01550	COG0142	geranyltranstransferase activity
VV1_RS01560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VV1_RS01565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VV1_RS01570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VV1_RS01575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VV1_RS01590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VV1_RS01590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VV1_RS01615	COG1073	alpha beta
VV1_RS01620	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VV1_RS01625	COG2252	PERMEase
VV1_RS01630	COG2195	Cleaves the N-terminal amino acid of tripeptides
VV1_RS01660	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VV1_RS01670	COG0583	DNA-binding transcription factor activity
VV1_RS01675	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VV1_RS01680	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VV1_RS01685	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VV1_RS01705	COG4969	Belongs to the N-Me-Phe pilin family
VV1_RS01715	COG0484	heat shock protein binding
VV1_RS01720	COG0443	Heat shock 70 kDa protein
VV1_RS01760	COG0497	DNA recombination
VV1_RS01765	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV1_RS01770	COG2914	Belongs to the UPF0125 (RnfH) family
VV1_RS01775	COG2867	negative regulation of translational initiation
VV1_RS01780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VV1_RS01785	COG0582	viral genome integration into host DNA
VV1_RS01835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VV1_RS01865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VV1_RS01895	COG1672	PFAM Archaeal ATPase
VV1_RS01895	COG2319	Wd-40 repeat
VV1_RS01995	COG0009	L-threonylcarbamoyladenylate synthase
VV1_RS02015	COG0583	DNA-binding transcription factor activity
VV1_RS02025	COG1115	amino acid carrier protein
VV1_RS02030	COG1584	GPR1 FUN34 yaaH family protein
VV1_RS02045	COG0517	IMP dehydrogenase activity
VV1_RS02045	COG0516	GMP reductase activity
VV1_RS02060	COG2203	Gaf domain
VV1_RS02060	COG2199	diguanylate cyclase activity
VV1_RS02075	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV1_RS02080	COG2976	Protein conserved in bacteria
VV1_RS02085	COG0124	histidyl-tRNA synthetase
VV1_RS02090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VV1_RS02105	COG0105	UTP biosynthetic process
VV1_RS02110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VV1_RS02115	COG2975	iron-sulfur cluster assembly
VV1_RS02120	COG0633	Ferredoxin
VV1_RS02135	COG0316	Belongs to the HesB IscA family
VV1_RS02140	COG0822	iron-sulfur transferase activity
VV1_RS02150	COG1959	2 iron, 2 sulfur cluster binding
VV1_RS02155	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VV1_RS02160	COG0483	inositol monophosphate 1-phosphatase activity
VV1_RS02165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV1_RS02170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV1_RS02175	COG1862	Preprotein translocase
VV1_RS02180	COG0343	queuine tRNA-ribosyltransferase activity
VV1_RS02195	COG0517	IMP dehydrogenase activity
VV1_RS02205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VV1_RS02210	COG0583	DNA-binding transcription factor activity
VV1_RS02215	COG0450	alkyl hydroperoxide reductase
VV1_RS02250	COG0704	Plays a role in the regulation of phosphate uptake
VV1_RS02255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VV1_RS02260	COG0581	inorganic phosphate transmembrane transporter activity
VV1_RS02265	COG0573	inorganic phosphate transmembrane transporter activity
VV1_RS02275	COG0248	Ppx GppA phosphatase
VV1_RS02285	COG5002	protein histidine kinase activity
VV1_RS02290	COG0745	RESPONSE REGULATOR receiver
VV1_RS02300	COG0826	peptidase U32
VV1_RS02305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VV1_RS02360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV1_RS02365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VV1_RS02370	COG1605	Chorismate mutase
VV1_RS02370	COG0077	Prephenate dehydratase
VV1_RS02380	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VV1_RS02390	COG0488	(ABC) transporter
VV1_RS02400	COG0739	heme binding
VV1_RS02405	COG0287	Prephenate dehydrogenase
VV1_RS02405	COG1605	Chorismate mutase
VV1_RS02440	COG1966	Carbon starvation protein
VV1_RS02445	COG3275	phosphorelay sensor kinase activity
VV1_RS02455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VV1_RS02460	COG1047	Peptidyl-prolyl cis-trans
VV1_RS02465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VV1_RS02475	COG0196	riboflavin kinase activity
VV1_RS02480	COG0728	peptidoglycan biosynthetic process
VV1_RS02485	COG0268	Binds directly to 16S ribosomal RNA
VV1_RS02490	COG0640	Transcriptional regulator
VV1_RS02495	COG0583	DNA-binding transcription factor activity
VV1_RS02500	COG1283	sodium-dependent phosphate transmembrane transporter activity
VV1_RS02520	COG0730	response to heat
VV1_RS02530	COG0494	nUDIX hydrolase
VV1_RS02535	COG3066	DNA modification
VV1_RS02545	COG0667	Aldo Keto reductase
VV1_RS02565	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VV1_RS02570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VV1_RS02575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VV1_RS02580	COG4974	Belongs to the 'phage' integrase family
VV1_RS02600	COG0513	Belongs to the DEAD box helicase family
VV1_RS02610	COG1115	amino acid carrier protein
VV1_RS02625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VV1_RS02635	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VV1_RS02640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VV1_RS02645	COG0083	homoserine kinase activity
VV1_RS02660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VV1_RS02670	COG0745	RESPONSE REGULATOR receiver
VV1_RS02680	COG0784	Response regulator, receiver
VV1_RS02680	COG5002	protein histidine kinase activity
VV1_RS02680	COG2198	Histidine kinase
VV1_RS02685	COG5001	Diguanylate cyclase
VV1_RS02685	COG2203	Gaf domain
VV1_RS02685	COG4251	negative regulation of phosphorylation
VV1_RS02685	COG3706	GGDEF domain
VV1_RS02690	COG1242	4 iron, 4 sulfur cluster binding
VV1_RS02695	COG0067	glutamate synthase
VV1_RS02695	COG0069	glutamate synthase activity
VV1_RS02695	COG0070	glutamate synthase
VV1_RS02705	COG0067	glutamate synthase
VV1_RS02705	COG0069	glutamate synthase activity
VV1_RS02705	COG0070	glutamate synthase
VV1_RS02710	COG0493	'glutamate synthase
VV1_RS02735	COG2860	membrane
VV1_RS02740	COG0583	DNA-binding transcription factor activity
VV1_RS02745	COG0730	response to heat
VV1_RS02755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VV1_RS02770	COG0494	nUDIX hydrolase
VV1_RS02785	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VV1_RS02790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VV1_RS02795	COG0849	cell division
VV1_RS02800	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VV1_RS02815	COG0772	Belongs to the SEDS family
VV1_RS02830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VV1_RS02840	COG0768	penicillin binding
VV1_RS02845	COG3116	cell division
VV1_RS02850	COG0275	rRNA processing
VV1_RS02855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VV1_RS02860	COG3107	peptidoglycan biosynthetic process
VV1_RS02865	COG0792	nuclease activity
VV1_RS02870	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VV1_RS02875	COG2823	Periplasmic or secreted lipoprotein
VV1_RS02880	COG2969	positive regulation of protein catabolic process
VV1_RS02885	COG0625	glutathione transferase activity
VV1_RS02890	COG2857	Cytochrome c1
VV1_RS02895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VV1_RS02900	COG0723	plastoquinol--plastocyanin reductase activity
VV1_RS02905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VV1_RS02910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VV1_RS02915	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VV1_RS02920	COG3105	Protein conserved in bacteria
VV1_RS02925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VV1_RS02930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VV1_RS02945	COG3150	esterase
VV1_RS02955	COG3151	Protein conserved in bacteria
VV1_RS02960	COG0494	nUDIX hydrolase
VV1_RS02965	COG1538	Outer membrane efflux protein
VV1_RS02985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VV1_RS02990	COG3025	triphosphatase activity
VV1_RS02995	COG1392	Phosphate transport regulator
VV1_RS03000	COG0306	phosphate transporter
VV1_RS03005	COG4991	sh3 domain protein
VV1_RS03010	COG3409	Peptidoglycan-binding domain 1 protein
VV1_RS03010	COG3267	Type II secretory pathway component ExeA
VV1_RS03020	COG1968	undecaprenyl-diphosphatase activity
VV1_RS03025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VV1_RS03030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VV1_RS03040	COG0596	Alpha beta hydrolase
VV1_RS03045	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VV1_RS03050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VV1_RS03055	COG1610	YqeY-like protein
VV1_RS03085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VV1_RS03090	COG2213	PTS system mannitol-specific
VV1_RS03090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV1_RS03100	COG3722	fumarate hydratase activity
VV1_RS03110	COG1349	DNA-binding transcription factor activity
VV1_RS03130	COG3706	GGDEF domain
VV1_RS03135	COG0440	acetolactate synthase activity
VV1_RS03140	COG0028	Belongs to the TPP enzyme family
VV1_RS03145	COG1022	Amp-dependent synthetase and ligase
VV1_RS03170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VV1_RS03215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VV1_RS03220	COG2967	ApaG domain
VV1_RS03235	COG3610	response to peptide
VV1_RS03250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VV1_RS03255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VV1_RS03260	COG0142	geranyltranstransferase activity
VV1_RS03270	COG1438	arginine binding
VV1_RS03275	COG2358	TRAP transporter, solute receptor (TAXI family
VV1_RS03285	COG0589	response to stress
VV1_RS03290	COG0204	Acyl-transferase
VV1_RS03300	COG5007	Belongs to the BolA IbaG family
VV1_RS03310	COG2854	intermembrane phospholipid transfer
VV1_RS03315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VV1_RS03320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VV1_RS03325	COG1127	ABC transporter
VV1_RS03335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VV1_RS03335	COG0517	IMP dehydrogenase activity
VV1_RS03340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VV1_RS03350	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VV1_RS03355	COG1137	ATPase activity
VV1_RS03365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VV1_RS03370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV1_RS03375	COG1660	Displays ATPase and GTPase activities
VV1_RS03380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV1_RS03385	COG2239	Acts as a magnesium transporter
VV1_RS03390	COG0312	modulator of DNA gyrase
VV1_RS03395	COG3028	Belongs to the UPF0307 family
VV1_RS03400	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VV1_RS03405	COG1178	ABC-type Fe3 transport system permease component
VV1_RS03410	COG4143	(ABC) transporter
VV1_RS03415	COG0163	prenyltransferase activity
VV1_RS03420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VV1_RS03425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VV1_RS03430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VV1_RS03440	COG2105	PFAM AIG2 family protein
VV1_RS03445	COG2911	Protein conserved in bacteria
VV1_RS03450	COG0729	surface antigen
VV1_RS03465	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VV1_RS03480	COG0577	efflux transmembrane transporter activity
VV1_RS03480	COG1136	(ABC) transporter
VV1_RS03500	COG0529	Catalyzes the synthesis of activated sulfate
VV1_RS03505	COG3273	potassium ion transport
VV1_RS03505	COG0471	metal ion transport
VV1_RS03515	COG0175	sulfate reduction
VV1_RS03520	COG1648	precorrin-2 dehydrogenase activity
VV1_RS03520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VV1_RS03525	COG0737	Belongs to the 5'-nucleotidase family
VV1_RS03535	COG2153	protein acetylation
VV1_RS03545	COG3061	Opacity-associated protein A
VV1_RS03545	COG3266	domain, Protein
VV1_RS03550	COG0545	Peptidyl-prolyl cis-trans isomerase
VV1_RS03560	COG0203	ribosomal protein L17
VV1_RS03565	COG0202	RNA polymerase activity
VV1_RS03570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VV1_RS03575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VV1_RS03580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VV1_RS03585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VV1_RS03590	COG0201	protein transport
VV1_RS03595	COG0200	Binds to the 23S rRNA
VV1_RS03600	COG1841	ribosomal large subunit assembly
VV1_RS03605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VV1_RS03610	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VV1_RS03615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VV1_RS03620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VV1_RS03625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VV1_RS03630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VV1_RS03635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VV1_RS03640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VV1_RS03645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VV1_RS03650	COG0255	Belongs to the universal ribosomal protein uL29 family
VV1_RS03655	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VV1_RS03660	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VV1_RS03670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VV1_RS03675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VV1_RS03680	COG0089	rRNA binding
VV1_RS03685	COG0088	Forms part of the polypeptide exit tunnel
VV1_RS03700	COG3064	Membrane
VV1_RS03705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VV1_RS03725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV1_RS03770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VV1_RS03775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VV1_RS03795	COG1596	polysaccharide export
VV1_RS03835	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV1_RS03850	COG0859	PFAM glycosyl transferase family 9
VV1_RS03855	COG1519	Transferase
VV1_RS03875	COG1083	cytidylyl-transferase
VV1_RS03895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VV1_RS03900	COG2089	acid synthase
VV1_RS03910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV1_RS03925	COG3083	sulfuric ester hydrolase activity
VV1_RS03935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VV1_RS03940	COG0859	PFAM glycosyl transferase family 9
VV1_RS03945	COG0463	Glycosyl transferase, family 2
VV1_RS03950	COG0859	PFAM glycosyl transferase family 9
VV1_RS03955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VV1_RS03975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VV1_RS03980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VV1_RS03985	COG2003	Belongs to the UPF0758 family
VV1_RS04000	COG1309	transcriptional regulator
VV1_RS04005	COG1560	Kdo2-lipid A biosynthetic process
VV1_RS04015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VV1_RS04020	COG1561	YicC-like family, N-terminal region
VV1_RS04040	COG4608	Belongs to the ABC transporter superfamily
VV1_RS04045	COG0444	Belongs to the ABC transporter superfamily
VV1_RS04050	COG0747	negative chemotaxis
VV1_RS04055	COG4239	(ABC) transporter, permease
VV1_RS04060	COG4174	ABC transporter (Permease)
VV1_RS04065	COG4206	TonB-dependent receptor
VV1_RS04075	COG0811	peptide transport
VV1_RS04080	COG0811	peptide transport
VV1_RS04085	COG0848	biopolymer transport protein
VV1_RS04100	COG0194	GDP metabolic process
VV1_RS04105	COG1758	RNA polymerase activity
VV1_RS04110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV1_RS04115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV1_RS04120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VV1_RS04125	COG2233	PERMEase
VV1_RS04145	COG2183	response to ionizing radiation
VV1_RS04165	COG0316	Belongs to the HesB IscA family
VV1_RS04165	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VV1_RS04170	COG0494	nUDIX hydrolase
VV1_RS04175	COG1218	3'(2'),5'-bisphosphate nucleotidase
VV1_RS04185	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VV1_RS04190	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VV1_RS04195	COG3156	type II secretion system protein K
VV1_RS04200	COG4795	General secretion pathway protein
VV1_RS04205	COG2165	general secretion pathway protein
VV1_RS04210	COG2165	general secretion pathway protein
VV1_RS04215	COG2165	general secretion pathway protein
VV1_RS04220	COG1459	type II secretion system
VV1_RS04225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV1_RS04235	COG3031	protein transport across the cell outer membrane
VV1_RS04240	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VV1_RS04245	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VV1_RS04260	COG0456	acetyltransferase
VV1_RS04265	COG1490	D-aminoacyl-tRNA deacylase activity
VV1_RS04285	COG1217	gtp-binding protein TYPA
VV1_RS04290	COG0174	glutamine synthetase
VV1_RS04300	COG3852	Histidine kinase
VV1_RS04345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV1_RS04345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV1_RS04355	COG0084	hydrolase, TatD family'
VV1_RS04360	COG0805	protein transport
VV1_RS04365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VV1_RS04380	COG3165	ubiquinone biosynthetic process from chorismate
VV1_RS04385	COG2226	methyltransferase
VV1_RS04390	COG1322	Protein conserved in bacteria
VV1_RS04405	COG3335	DDE superfamily endonuclease
VV1_RS04505	COG3118	belongs to the thioredoxin family
VV1_RS04515	COG0248	Ppx GppA phosphatase
VV1_RS04520	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VV1_RS04530	COG0514	ATP-dependent DNA helicase (RecQ)
VV1_RS04535	COG2962	Rard protein
VV1_RS04545	COG1280	lysine exporter protein (LysE YggA)
VV1_RS04550	COG0210	DNA helicase
VV1_RS04590	COG0006	proline dipeptidase activity
VV1_RS04590	COG0006	proline dipeptidase activity
VV1_RS04600	COG2022	thiamine diphosphate biosynthetic process
VV1_RS04610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VV1_RS04620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VV1_RS04625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VV1_RS04630	COG2132	Multicopper oxidase
VV1_RS04640	COG3335	DDE superfamily endonuclease
VV1_RS04680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV1_RS04685	COG1739	Uncharacterized protein family UPF0029
VV1_RS04700	COG0604	alcohol dehydrogenase
VV1_RS04715	COG0425	Belongs to the sulfur carrier protein TusA family
VV1_RS04725	COG2119	membrane
VV1_RS04730	COG0752	glycyl-tRNA synthetase alpha subunit
VV1_RS04745	COG3977	Valine--pyruvate aminotransferase
VV1_RS04755	COG0071	Belongs to the small heat shock protein (HSP20) family
VV1_RS04760	COG0187	DNA topoisomerase II activity
VV1_RS04770	COG0592	DNA-directed DNA polymerase activity
VV1_RS04790	COG1126	abc transporter atp-binding protein
VV1_RS04795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VV1_RS04800	COG0594	ribonuclease P activity
VV1_RS04815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VV1_RS04825	COG0357	Ribosomal RNA small subunit methyltransferase G
VV1_RS04830	COG1192	Involved in chromosome partitioning
VV1_RS04835	COG1475	DNA binding
VV1_RS04840	COG3312	ion transport
VV1_RS04845	COG0356	it plays a direct role in the translocation of protons across the membrane
VV1_RS04855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VV1_RS04860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VV1_RS04865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VV1_RS04870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VV1_RS04875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VV1_RS04880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VV1_RS04890	COG0765	amino acid transport
VV1_RS04900	COG2814	Major facilitator Superfamily
VV1_RS04905	COG0583	DNA-binding transcription factor activity
VV1_RS04920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VV1_RS04925	COG3978	acetolactate synthase activity
VV1_RS04935	COG0606	chelatase, subunit chli
VV1_RS04945	COG0204	Acyl-transferase
VV1_RS04950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VV1_RS04955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VV1_RS04965	COG3084	Protein conserved in bacteria
VV1_RS04970	COG4326	sporulation control protein
VV1_RS04975	COG1272	protein, Hemolysin III
VV1_RS04980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV1_RS04985	COG0569	domain protein
VV1_RS05000	COG0242	peptide deformylase activity
VV1_RS05010	COG0758	DNA mediated transformation
VV1_RS05015	COG2922	Belongs to the Smg family
VV1_RS05020	COG0551	DNA topoisomerase type I activity
VV1_RS05030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VV1_RS05035	COG0009	L-threonylcarbamoyladenylate synthase
VV1_RS05055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VV1_RS05095	COG3335	DDE superfamily endonuclease
VV1_RS05110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VV1_RS05115	COG2960	long-chain fatty acid transporting porin activity
VV1_RS05120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV1_RS05125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV1_RS05130	COG1309	transcriptional regulator
VV1_RS05170	COG4172	Belongs to the ABC transporter superfamily
VV1_RS05175	COG4166	transmembrane transport
VV1_RS05180	COG0601	transmembrane transport
VV1_RS05185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV1_RS05220	COG2815	serine threonine protein kinase
VV1_RS05220	COG0515	serine threonine protein kinase
VV1_RS05230	COG0745	RESPONSE REGULATOR receiver
VV1_RS05235	COG1609	Transcriptional regulator
VV1_RS05240	COG0129	dihydroxy-acid dehydratase activity
VV1_RS05245	COG3265	gluconokinase activity
VV1_RS05250	COG2610	gluconate transmembrane transporter activity
VV1_RS05255	COG0800	Aldolase
VV1_RS05275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV1_RS05280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VV1_RS05290	COG1522	sequence-specific DNA binding
VV1_RS05295	COG5001	Diguanylate cyclase
VV1_RS05295	COG5002	protein histidine kinase activity
VV1_RS05315	COG0589	response to stress
VV1_RS05320	COG1528	Iron-storage protein
VV1_RS05330	COG2081	HI0933 family
VV1_RS05340	COG2959	enzyme of heme biosynthesis
VV1_RS05350	COG0181	hydroxymethylbilane synthase activity
VV1_RS05355	COG3072	Adenylate cyclase
VV1_RS05360	COG1965	Belongs to the frataxin family
VV1_RS05370	COG0019	diaminopimelate decarboxylase activity
VV1_RS05375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VV1_RS05385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VV1_RS05390	COG1011	Hydrolase
VV1_RS05395	COG3287	FIST C domain
VV1_RS05395	COG2200	EAL domain
VV1_RS05395	COG2199	diguanylate cyclase activity
VV1_RS05400	COG3148	PFAM DTW domain containing protein
VV1_RS05415	COG0561	phosphatase activity
VV1_RS05420	COG2267	carboxylic ester hydrolase activity
VV1_RS05425	COG1280	lysine exporter protein (LysE YggA)
VV1_RS05430	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VV1_RS05435	COG0640	Transcriptional regulator
VV1_RS05440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VV1_RS05480	COG2095	MarC family integral membrane protein
VV1_RS05490	COG0742	ribosomal rna small subunit methyltransferase
VV1_RS05495	COG0552	protein localization to endoplasmic reticulum
VV1_RS05500	COG2884	Cell division ATP-binding protein ftsE
VV1_RS05505	COG2177	Part of the ABC transporter FtsEX involved in
VV1_RS05515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV1_RS05525	COG1580	Controls the rotational direction of flagella during chemotaxis
VV1_RS05545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VV1_RS05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV1_RS05630	COG3335	DDE superfamily endonuclease
VV1_RS05640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VV1_RS05685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VV1_RS05690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VV1_RS05705	COG0081	regulation of translation
VV1_RS05710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VV1_RS05715	COG0222	ribosome binding
VV1_RS05720	COG0085	RNA polymerase activity
VV1_RS05725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VV1_RS05730	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VV1_RS05750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VV1_RS05755	COG1573	uracil-dna glycosylase
VV1_RS05760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV1_RS05765	COG3068	Protein conserved in bacteria
VV1_RS05770	COG1253	flavin adenine dinucleotide binding
VV1_RS05790	COG0138	bifunctional purine biosynthesis protein purh
VV1_RS05795	COG0789	Transcriptional regulator
VV1_RS05800	COG0840	transmembrane signaling receptor activity
VV1_RS05805	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VV1_RS05820	COG0439	Biotin carboxylase
VV1_RS05825	COG0511	ligase activity, forming carbon-carbon bonds
VV1_RS05830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VV1_RS05850	COG2814	Major facilitator Superfamily
VV1_RS05855	COG2205	protein histidine kinase activity
VV1_RS05855	COG0784	Response regulator, receiver
VV1_RS05855	COG2198	Histidine kinase
VV1_RS05875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VV1_RS05885	COG2095	MarC family integral membrane protein
VV1_RS05900	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VV1_RS05905	COG1027	Aspartate ammonia-lyase
VV1_RS05915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VV1_RS05925	COG2205	protein histidine kinase activity
VV1_RS05930	COG0745	RESPONSE REGULATOR receiver
VV1_RS05935	COG3678	ATP-independent chaperone mediated protein folding
VV1_RS05945	COG0205	6-phosphofructokinase activity
VV1_RS05950	COG0534	Mate efflux family protein
VV1_RS05955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VV1_RS05960	COG0459	protein refolding
VV1_RS05970	COG1285	pathogenesis
VV1_RS05975	COG1509	lysine 2,3-aminomutase activity
VV1_RS05980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VV1_RS05995	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VV1_RS06000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VV1_RS06005	COG1053	succinate dehydrogenase
VV1_RS06010	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VV1_RS06030	COG3385	transposase activity
VV1_RS06035	COG4942	peptidase
VV1_RS06040	COG1045	serine acetyltransferase
VV1_RS06045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VV1_RS06050	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VV1_RS06055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV1_RS06070	COG0471	metal ion transport
VV1_RS06075	COG0688	phosphatidylethanolamine metabolic process
VV1_RS06080	COG1162	GTPase activity
VV1_RS06085	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VV1_RS06135	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VV1_RS06140	COG0802	atpase or kinase
VV1_RS06145	COG0860	N-Acetylmuramoyl-L-alanine amidase
VV1_RS06160	COG1923	regulation of RNA biosynthetic process
VV1_RS06165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VV1_RS06170	COG0330	HflC and HflK could
VV1_RS06175	COG0330	HflC and HflK could
VV1_RS06180	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VV1_RS06190	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VV1_RS06200	COG1959	2 iron, 2 sulfur cluster binding
VV1_RS06205	COG0402	S-adenosylhomocysteine deaminase activity
VV1_RS06210	COG0557	exoribonuclease II activity
VV1_RS06215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV1_RS06265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV1_RS06270	COG3954	Phosphoribulokinase
VV1_RS06275	COG3089	Belongs to the UPF0270 family
VV1_RS06280	COG0429	hydrolase of the alpha beta-hydrolase fold
VV1_RS06290	COG0488	(ABC) transporter
VV1_RS06295	COG2249	NAD(P)H dehydrogenase (quinone) activity
VV1_RS06310	COG1047	Peptidyl-prolyl cis-trans
VV1_RS06320	COG2900	Belongs to the SlyX family
VV1_RS06330	COG0545	Peptidyl-prolyl cis-trans isomerase
VV1_RS06335	COG2964	Protein conserved in bacteria
VV1_RS06350	COG2168	tRNA wobble position uridine thiolation
VV1_RS06355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VV1_RS06360	COG0049	tRNA binding
VV1_RS06365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VV1_RS06375	COG2906	2 iron, 2 sulfur cluster binding
VV1_RS06385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VV1_RS06390	COG0149	triose-phosphate isomerase activity
VV1_RS06415	COG1494	fructose-1,6-bisphosphatase
VV1_RS06420	COG3074	FtsZ-dependent cytokinesis
VV1_RS06430	COG1575	Belongs to the MenA family. Type 1 subfamily
VV1_RS06435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VV1_RS06440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VV1_RS06450	COG1609	Transcriptional regulator
VV1_RS06455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VV1_RS06465	COG0281	malic enzyme
VV1_RS06470	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VV1_RS06475	COG0626	cystathionine gamma-synthase activity
VV1_RS06480	COG0527	aspartate kinase activity
VV1_RS06480	COG0460	homoserine dehydrogenase
VV1_RS06485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VV1_RS06515	COG0137	argininosuccinate synthase activity
VV1_RS06520	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VV1_RS06520	COG0165	Argininosuccinate lyase
VV1_RS06535	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VV1_RS06565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VV1_RS06570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VV1_RS06580	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VV1_RS06585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VV1_RS06590	COG0360	Binds together with S18 to 16S ribosomal RNA
VV1_RS06595	COG2965	DNA replication, synthesis of RNA primer
VV1_RS06605	COG0359	binds to the 23S rRNA
VV1_RS06620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VV1_RS06630	COG0432	Pfam Uncharacterised protein family UPF0047
VV1_RS06645	COG0735	belongs to the Fur family
VV1_RS06735	COG0527	aspartate kinase activity
VV1_RS06740	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VV1_RS06770	COG2200	EAL domain
VV1_RS06770	COG2199	diguanylate cyclase activity
VV1_RS06795	COG3409	Peptidoglycan-binding domain 1 protein
VV1_RS06795	COG3267	Type II secretory pathway component ExeA
VV1_RS06805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV1_RS06810	COG1459	type II secretion system
VV1_RS06820	COG2165	general secretion pathway protein
VV1_RS06825	COG2165	general secretion pathway protein
VV1_RS06855	COG1077	Cell shape determining protein MreB Mrl
VV1_RS06860	COG1792	Involved in formation and maintenance of cell shape
VV1_RS06865	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VV1_RS06870	COG0424	maF-like protein
VV1_RS06880	COG3164	Protein of unknown function
VV1_RS06885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VV1_RS06890	COG0312	modulator of DNA gyrase
VV1_RS06895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VV1_RS06910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV1_RS06915	COG0251	oxidation-reduction process
VV1_RS06950	COG0456	acetyltransferase
VV1_RS06960	COG4269	membrane
VV1_RS06970	COG0525	valine-tRNA ligase activity
VV1_RS06975	COG2927	DNA polymerase III (CHI subunit)
VV1_RS06980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VV1_RS06985	COG0795	lipopolysaccharide-transporting ATPase activity
VV1_RS06990	COG0795	lipopolysaccharide-transporting ATPase activity
VV1_RS07005	COG0726	polysaccharide deacetylase
VV1_RS07010	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VV1_RS07020	COG1447	Phosphotransferase system cellobiose-specific component IIA
VV1_RS07025	COG1486	melibiose metabolic process
VV1_RS07035	COG1609	Transcriptional regulator
VV1_RS07045	COG3437	response regulator, receiver
VV1_RS07150	COG0741	lytic transglycosylase activity
VV1_RS07155	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VV1_RS07165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VV1_RS07170	COG2066	Belongs to the glutaminase family
VV1_RS07180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VV1_RS07185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VV1_RS07200	COG0762	integral membrane protein
VV1_RS07205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VV1_RS07210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VV1_RS07225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VV1_RS07230	COG1678	Uncharacterized ACR, COG1678
VV1_RS07240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VV1_RS07250	COG2356	endonuclease I
VV1_RS07265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VV1_RS07285	COG0126	phosphoglycerate kinase activity
VV1_RS07290	COG0191	fructose-bisphosphate aldolase activity
VV1_RS07295	COG0668	transmembrane transport
VV1_RS07300	COG1279	arginine transmembrane transporter activity
VV1_RS07315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VV1_RS07325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VV1_RS07330	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VV1_RS07340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV1_RS07345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV1_RS07375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VV1_RS07380	COG1595	DNA-templated transcription, initiation
VV1_RS07395	COG3086	response to oxidative stress
VV1_RS07400	COG0481	GTPase activity
VV1_RS07415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VV1_RS07425	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VV1_RS07445	COG5001	Diguanylate cyclase
VV1_RS07450	COG3850	Histidine kinase
VV1_RS07450	COG4999	Histidine kinase
VV1_RS07450	COG3437	response regulator, receiver
VV1_RS07450	COG2205	protein histidine kinase activity
VV1_RS07460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV1_RS07465	COG3956	TIGRFAM MazG family protein
VV1_RS07470	COG0504	CTP synthase activity
VV1_RS07480	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VV1_RS07505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VV1_RS07510	COG1388	LysM domain
VV1_RS07510	COG4942	peptidase
VV1_RS07515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VV1_RS07530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VV1_RS07550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VV1_RS07595	COG3630	sodium ion export across plasma membrane
VV1_RS07600	COG5016	pyruvate
VV1_RS07600	COG0511	ligase activity, forming carbon-carbon bonds
VV1_RS07605	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VV1_RS07615	COG1238	metal cluster binding
VV1_RS07620	COG0612	Peptidase, M16
VV1_RS07635	COG1854	S-ribosylhomocysteine lyase activity
VV1_RS07640	COG4536	flavin adenine dinucleotide binding
VV1_RS07645	COG4137	Cytochrome C assembly protein
VV1_RS07650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VV1_RS07655	COG0228	four-way junction DNA binding
VV1_RS07660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VV1_RS07665	COG0336	Belongs to the RNA methyltransferase TrmD family
VV1_RS07670	COG0335	large ribosomal subunit rRNA binding
VV1_RS07695	COG1459	type II secretion system
VV1_RS07700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV1_RS07715	COG3023	N-Acetylmuramoyl-L-alanine amidase
VV1_RS07720	COG2186	Transcriptional regulator
VV1_RS07725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VV1_RS07730	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV1_RS07735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV1_RS07750	COG0288	reversible hydration of carbon dioxide
VV1_RS07755	COG0659	secondary active sulfate transmembrane transporter activity
VV1_RS07760	COG1131	(ABC) transporter
VV1_RS07765	COG0842	Transport permease protein
VV1_RS07775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VV1_RS07780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VV1_RS07795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VV1_RS07805	COG1643	Atp-dependent helicase
VV1_RS07810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VV1_RS07815	COG1752	Esterase of the alpha-beta hydrolase superfamily
VV1_RS07820	COG1049	propionate catabolic process, 2-methylcitrate cycle
VV1_RS07825	COG1929	Belongs to the glycerate kinase type-1 family
VV1_RS07830	COG2610	gluconate transmembrane transporter activity
VV1_RS07835	COG3835	regulator
VV1_RS07840	COG3112	Uncharacterised protein family (UPF0231)
VV1_RS07845	COG0347	Belongs to the P(II) protein family
VV1_RS07850	COG0004	ammonium transporteR
VV1_RS07855	COG1840	ABC-type Fe3 transport system, periplasmic component
VV1_RS07870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV1_RS07885	COG2971	BadF BadG BcrA BcrD
VV1_RS07895	COG4608	Belongs to the ABC transporter superfamily
VV1_RS07900	COG0444	Belongs to the ABC transporter superfamily
VV1_RS07905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV1_RS07910	COG0601	transmembrane transport
VV1_RS07920	COG2205	protein histidine kinase activity
VV1_RS07920	COG0784	Response regulator, receiver
VV1_RS07930	COG0628	permease
VV1_RS07955	COG0739	heme binding
VV1_RS07960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VV1_RS07965	COG2832	Protein of unknown function (DUF454)
VV1_RS07970	COG2027	D-alanyl-D-alanine carboxypeptidase
VV1_RS07990	COG1534	Rna-binding protein
VV1_RS07995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VV1_RS08000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VV1_RS08005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VV1_RS08015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VV1_RS08030	COG0779	Required for maturation of 30S ribosomal subunits
VV1_RS08035	COG0195	Participates in both transcription termination and antitermination
VV1_RS08045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VV1_RS08050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VV1_RS08055	COG3385	transposase activity
VV1_RS08060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VV1_RS08090	COG1185	polyribonucleotide nucleotidyltransferase activity
VV1_RS08105	COG0534	Mate efflux family protein
VV1_RS08110	COG0826	peptidase U32
VV1_RS08115	COG0826	peptidase U32
VV1_RS08125	COG3154	lipid carrier protein
VV1_RS08130	COG3153	acetyltransferase
VV1_RS08140	COG0456	acetyltransferase
VV1_RS08150	COG3706	GGDEF domain
VV1_RS08160	COG0084	hydrolase, TatD family'
VV1_RS08165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VV1_RS08175	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VV1_RS08180	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VV1_RS08185	COG0813	purine-nucleoside phosphorylase activity
VV1_RS08195	COG0560	Phosphoserine phosphatase
VV1_RS08205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VV1_RS08225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VV1_RS08230	COG0583	DNA-binding transcription factor activity
VV1_RS08240	COG1022	Amp-dependent synthetase and ligase
VV1_RS08275	COG4964	Belongs to the GSP D family
VV1_RS08325	COG2059	Chromate
VV1_RS08330	COG0583	DNA-binding transcription factor activity
VV1_RS08340	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
VV1_RS08340	COG3408	Glycogen debranching enzyme
VV1_RS08345	COG0531	amino acid
VV1_RS08350	COG0531	amino acid
VV1_RS08355	COG2731	YhcH YjgK YiaL family protein
VV1_RS08360	COG3250	beta-galactosidase activity
VV1_RS08370	COG1609	Transcriptional regulator
VV1_RS08375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VV1_RS08390	COG2017	converts alpha-aldose to the beta-anomer
VV1_RS08395	COG0840	transmembrane signaling receptor activity
VV1_RS08405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV1_RS08425	COG0569	domain protein
VV1_RS08425	COG0189	ligase activity
VV1_RS08440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VV1_RS08445	COG1349	DNA-binding transcription factor activity
VV1_RS08450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VV1_RS08455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VV1_RS08460	COG2171	N-acyltransferase activity
VV1_RS08465	COG3141	response to X-ray
VV1_RS08480	COG3083	sulfuric ester hydrolase activity
VV1_RS08485	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VV1_RS08490	COG1074	ATP-dependent DNA helicase activity
VV1_RS08495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VV1_RS08515	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VV1_RS08520	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VV1_RS08525	COG2166	iron-sulfur cluster assembly
VV1_RS08530	COG0840	transmembrane signaling receptor activity
VV1_RS08545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VV1_RS08550	COG0693	protein deglycase activity
VV1_RS08555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VV1_RS08560	COG3248	Nucleoside-binding outer membrane protein
VV1_RS08570	COG1595	DNA-templated transcription, initiation
VV1_RS08580	COG2211	Major facilitator Superfamily
VV1_RS08595	COG2813	Specifically methylates the guanine in position
VV1_RS08600	COG0271	Belongs to the BolA IbaG family
VV1_RS08605	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV1_RS08610	COG1805	sodium ion transport
VV1_RS08615	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV1_RS08625	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV1_RS08630	COG2871	sodium ion transport
VV1_RS08635	COG1477	protein flavinylation
VV1_RS08650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VV1_RS08655	COG0514	ATP-dependent DNA helicase (RecQ)
VV1_RS08670	COG0733	neurotransmitter:sodium symporter activity
VV1_RS08695	COG1720	tRNA m6t6A37 methyltransferase activity
VV1_RS08705	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VV1_RS08725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VV1_RS08765	COG3098	single-species biofilm formation
VV1_RS08785	COG0024	Methionine aminopeptidase
VV1_RS08790	COG0052	Belongs to the universal ribosomal protein uS2 family
VV1_RS08795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VV1_RS08800	COG0528	UMP kinase activity
VV1_RS08810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VV1_RS08815	COG0575	Belongs to the CDS family
VV1_RS08825	COG0750	zinc metalloprotease
VV1_RS08830	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV1_RS08835	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VV1_RS08845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VV1_RS08850	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV1_RS08855	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV1_RS08860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VV1_RS08865	COG0587	DNA-directed DNA polymerase activity
VV1_RS08870	COG0825	malonyl-CoA metabolic process
VV1_RS08885	COG0347	Belongs to the P(II) protein family
VV1_RS08900	COG0741	lytic transglycosylase activity
VV1_RS08900	COG1388	LysM domain
VV1_RS08905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV1_RS08910	COG2226	methyltransferase
VV1_RS08915	COG0328	RNA-DNA hybrid ribonuclease activity
VV1_RS08930	COG2249	NAD(P)H dehydrogenase (quinone) activity
VV1_RS08960	COG1960	acyl-CoA dehydrogenase activity
VV1_RS08970	COG0121	glutamine amidotransferase
VV1_RS08975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VV1_RS08980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VV1_RS08985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VV1_RS08990	COG2233	PERMEase
VV1_RS09010	COG1393	Belongs to the ArsC family
VV1_RS09015	COG4783	chaperone-mediated protein folding
VV1_RS09030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VV1_RS09035	COG2716	regulation of RNA biosynthetic process
VV1_RS09045	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VV1_RS09065	COG1393	Belongs to the ArsC family
VV1_RS09095	COG2837	iron assimilation
VV1_RS09100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV1_RS09105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV1_RS09110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV1_RS09115	COG1334	flagellar protein FlaG
VV1_RS09120	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VV1_RS09130	COG1516	flagellar protein fliS
VV1_RS09150	COG1677	Flagellar hook-basal body complex protein FliE
VV1_RS09160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VV1_RS09210	COG1987	bacterial-type flagellum assembly
VV1_RS09215	COG1684	flagellar biosynthetic protein fliR
VV1_RS09250	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VV1_RS09255	COG0643	Histidine kinase
VV1_RS09255	COG2198	Histidine kinase
VV1_RS09255	COG0784	Response regulator, receiver
VV1_RS09265	COG1192	Involved in chromosome partitioning
VV1_RS09275	COG0835	chemotaxis
VV1_RS09290	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV1_RS09295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV1_RS09300	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV1_RS09305	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VV1_RS09310	COG1138	Cytochrome C-type biogenesis protein
VV1_RS09315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VV1_RS09320	COG3088	subunit of a heme lyase
VV1_RS09320	COG4235	cytochrome complex assembly
VV1_RS09330	COG2853	Lipoprotein
VV1_RS09340	COG2067	long-chain fatty acid transport protein
VV1_RS09365	COG1025	Belongs to the peptidase M16 family
VV1_RS09370	COG2062	phosphohistidine phosphatase, SixA
VV1_RS09380	COG2890	protein-(glutamine-N5) methyltransferase activity
VV1_RS09390	COG2860	membrane
VV1_RS09395	COG3101	peptidyl-lysine hydroxylation
VV1_RS09410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VV1_RS09420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VV1_RS09430	COG0101	tRNA pseudouridine synthase activity
VV1_RS09435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VV1_RS09440	COG0285	dihydrofolate synthase activity
VV1_RS09445	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VV1_RS09450	COG1286	toxin biosynthetic process
VV1_RS09455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VV1_RS09460	COG0583	DNA-binding transcription factor activity
VV1_RS09465	COG0745	RESPONSE REGULATOR receiver
VV1_RS09475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VV1_RS09485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VV1_RS09490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VV1_RS09505	COG2205	protein histidine kinase activity
VV1_RS09510	COG0745	RESPONSE REGULATOR receiver
VV1_RS09535	COG0346	lactoylglutathione lyase activity
VV1_RS09545	COG1785	Belongs to the alkaline phosphatase family
VV1_RS09560	COG2226	methyltransferase
VV1_RS09565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VV1_RS09675	COG1396	sequence-specific DNA binding
VV1_RS09680	COG3550	peptidyl-serine autophosphorylation
VV1_RS09690	COG2239	Acts as a magnesium transporter
VV1_RS09695	COG2203	Gaf domain
VV1_RS09695	COG2199	diguanylate cyclase activity
VV1_RS09710	COG3710	Transcriptional regulator
VV1_RS09715	COG0531	amino acid
VV1_RS09720	COG1982	Orn Lys Arg decarboxylase major
VV1_RS09725	COG3706	GGDEF domain
VV1_RS09730	COG0517	IMP dehydrogenase activity
VV1_RS09730	COG0617	tRNA 3'-terminal CCA addition
VV1_RS09730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VV1_RS09755	COG0537	adenosine 5'-monophosphoramidase activity
VV1_RS09785	COG1252	NADH dehydrogenase
VV1_RS09800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VV1_RS09810	COG4591	ABC-type transport system involved in lipoprotein release permease component
VV1_RS09815	COG1136	(ABC) transporter
VV1_RS09820	COG4591	ABC-type transport system involved in lipoprotein release permease component
VV1_RS09830	COG0658	competence protein
VV1_RS09830	COG2333	competence protein COMEC
VV1_RS09845	COG2835	tetraacyldisaccharide 4'-kinase activity
VV1_RS09855	COG2199	diguanylate cyclase activity
VV1_RS09860	COG2719	SpoVR family
VV1_RS09870	COG2766	serine protein kinase
VV1_RS09875	COG3013	Belongs to the UPF0304 family
VV1_RS09885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VV1_RS09900	COG1882	Formate acetyltransferase
VV1_RS09940	COG0708	Exodeoxyribonuclease III
VV1_RS09945	COG0840	transmembrane signaling receptor activity
VV1_RS09955	COG3923	Primosomal replication protein n
VV1_RS09965	COG1199	ATP-dependent helicase activity
VV1_RS09970	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VV1_RS09990	COG1278	Cold shock
VV1_RS09995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VV1_RS10000	COG0542	response to heat
VV1_RS10005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VV1_RS10025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VV1_RS10035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VV1_RS10065	COG3070	regulator of competence-specific genes
VV1_RS10070	COG1609	Transcriptional regulator
VV1_RS10080	COG0745	RESPONSE REGULATOR receiver
VV1_RS10085	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VV1_RS10090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VV1_RS10100	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VV1_RS10135	COG4067	protein conserved in archaea
VV1_RS10135	COG0189	ligase activity
VV1_RS10140	COG0500	methyltransferase
VV1_RS10165	COG0840	transmembrane signaling receptor activity
VV1_RS10170	COG0632	four-way junction helicase activity
VV1_RS10175	COG2255	four-way junction helicase activity
VV1_RS10180	COG1271	oxidase subunit
VV1_RS10185	COG1294	oxidase, subunit
VV1_RS10200	COG0824	Thioesterase
VV1_RS10205	COG0811	peptide transport
VV1_RS10225	COG2885	chlorophyll binding
VV1_RS10230	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VV1_RS10245	COG3766	membrane
VV1_RS10255	COG0754	glutathionylspermidine amidase activity
VV1_RS10265	COG0784	Response regulator, receiver
VV1_RS10265	COG2205	protein histidine kinase activity
VV1_RS10345	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VV1_RS10360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VV1_RS10365	COG0840	transmembrane signaling receptor activity
VV1_RS10370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV1_RS10375	COG0861	Integral membrane protein TerC family
VV1_RS10390	COG2207	Transcriptional regulator
VV1_RS10435	COG0583	DNA-binding transcription factor activity
VV1_RS10445	COG0280	phosphate acetyltransferase
VV1_RS10445	COG0857	belongs to the CobB CobQ family
VV1_RS10450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VV1_RS10455	COG3092	negative regulation of chromosome organization
VV1_RS10465	COG4120	Belongs to the binding-protein-dependent transport system permease family
VV1_RS10475	COG0366	Alpha amylase catalytic
VV1_RS10490	COG0653	protein targeting
VV1_RS10505	COG2186	Transcriptional regulator
VV1_RS10520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VV1_RS10545	COG1846	Transcriptional regulator
VV1_RS10550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VV1_RS10555	COG0840	transmembrane signaling receptor activity
VV1_RS10575	COG1448	Aminotransferase
VV1_RS10580	COG2770	Histidine kinase
VV1_RS10580	COG3437	response regulator, receiver
VV1_RS10595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV1_RS10605	COG0017	Asparaginyl-tRNA synthetase
VV1_RS10610	COG0840	transmembrane signaling receptor activity
VV1_RS10615	COG0720	synthase
VV1_RS10625	COG2200	EAL domain
VV1_RS10630	COG1760	l-serine dehydratase
VV1_RS10635	COG0814	amino acid
VV1_RS10640	COG0494	nUDIX hydrolase
VV1_RS10650	COG2205	protein histidine kinase activity
VV1_RS10650	COG0784	Response regulator, receiver
VV1_RS10660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VV1_RS10675	COG3106	COG3106 Predicted ATPase
VV1_RS10680	COG3768	UPF0283 membrane protein
VV1_RS10685	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VV1_RS10690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV1_RS10705	COG0471	metal ion transport
VV1_RS10710	COG4191	Histidine kinase
VV1_RS10710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV1_RS10720	COG3706	GGDEF domain
VV1_RS10725	COG2200	EAL domain
VV1_RS10725	COG2199	diguanylate cyclase activity
VV1_RS10740	COG3300	MHYT domain
VV1_RS10740	COG5001	Diguanylate cyclase
VV1_RS10745	COG1328	CTP reductase activity
VV1_RS10750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VV1_RS10755	COG0583	DNA-binding transcription factor activity
VV1_RS10770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VV1_RS10775	COG4667	esterase of the alpha-beta hydrolase superfamily
VV1_RS10785	COG1597	lipid kinase activity
VV1_RS10790	COG0814	amino acid
VV1_RS10805	COG0783	Belongs to the Dps family
VV1_RS10820	COG1132	(ABC) transporter
VV1_RS10825	COG1132	(ABC) transporter
VV1_RS10830	COG1115	amino acid carrier protein
VV1_RS10845	COG1596	polysaccharide export
VV1_RS10870	COG0438	transferase activity, transferring glycosyl groups
VV1_RS10875	COG0438	transferase activity, transferring glycosyl groups
VV1_RS10875	COG0297	glycogen (starch) synthase activity
VV1_RS10890	COG2165	general secretion pathway protein
VV1_RS10920	COG0443	Heat shock 70 kDa protein
VV1_RS10925	COG0443	Heat shock 70 kDa protein
VV1_RS10935	COG3706	GGDEF domain
VV1_RS10955	COG3713	MltA-interacting MipA family protein
VV1_RS10985	COG4964	Belongs to the GSP D family
VV1_RS10995	COG2894	cell division
VV1_RS11045	COG1643	Atp-dependent helicase
VV1_RS11070	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VV1_RS11080	COG2814	Major facilitator Superfamily
VV1_RS11095	COG0840	transmembrane signaling receptor activity
VV1_RS11100	COG0010	Belongs to the arginase family
VV1_RS11105	COG1166	arginine decarboxylase activity
VV1_RS11170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VV1_RS11195	COG0776	regulation of translation
VV1_RS11205	COG0500	methyltransferase
VV1_RS11210	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VV1_RS11230	COG2885	chlorophyll binding
VV1_RS11245	COG0277	FAD linked oxidase domain protein
VV1_RS11245	COG0247	lactate metabolic process
VV1_RS11250	COG2020	methyltransferase activity
VV1_RS11255	COG5640	endopeptidase activity
VV1_RS11290	COG4326	sporulation control protein
VV1_RS11310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VV1_RS11340	COG4628	conserved protein (DUF2132)
VV1_RS11435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VV1_RS11435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VV1_RS11525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV1_RS11605	COG1715	Restriction endonuclease
VV1_RS11675	COG0582	viral genome integration into host DNA
VV1_RS11755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV1_RS11815	COG0791	NLP P60 protein
VV1_RS11880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV1_RS11935	COG1280	lysine exporter protein (LysE YggA)
VV1_RS11945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV1_RS12035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV1_RS12090	COG1942	4-Oxalocrotonate Tautomerase
VV1_RS12125	COG0456	acetyltransferase
VV1_RS12180	COG2801	Transposase and inactivated derivatives
VV1_RS12215	COG0307	riboflavin synthase, alpha
VV1_RS12235	COG3706	GGDEF domain
VV1_RS12245	COG0791	NLP P60 protein
VV1_RS12250	COG0840	transmembrane signaling receptor activity
VV1_RS12260	COG3148	PFAM DTW domain containing protein
VV1_RS12265	COG1940	carbohydrate kinase activity
VV1_RS12285	COG3842	ATPase activity
VV1_RS12290	COG4662	Binding-protein-dependent transport system inner membrane component
VV1_RS12300	COG2204	response regulator
VV1_RS12305	COG3852	Histidine kinase
VV1_RS12320	COG0488	(ABC) transporter
VV1_RS12330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VV1_RS12360	COG3383	formate dehydrogenase (NAD+) activity
VV1_RS12360	COG0243	molybdopterin cofactor binding
VV1_RS12365	COG0437	4 iron, 4 sulfur cluster binding
VV1_RS12395	COG0004	ammonium transporteR
VV1_RS12405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VV1_RS12415	COG1177	transmembrane transport
VV1_RS12420	COG1176	ABC-type spermidine putrescine transport system, permease component I
VV1_RS12425	COG3842	ATPase activity
VV1_RS12435	COG2992	FlgJ-related protein
VV1_RS12450	COG0589	response to stress
VV1_RS12455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV1_RS12470	COG2217	Heavy metal translocating P-type atpase
VV1_RS12480	COG2010	Cytochrome c
VV1_RS12495	COG3278	Belongs to the heme-copper respiratory oxidase family
VV1_RS12510	COG2205	protein histidine kinase activity
VV1_RS12510	COG0784	Response regulator, receiver
VV1_RS12535	COG1067	ATP-dependent peptidase activity
VV1_RS12540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VV1_RS12555	COG0488	(ABC) transporter
VV1_RS12565	COG0116	Belongs to the methyltransferase superfamily
VV1_RS12565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VV1_RS12580	COG2902	Dehydrogenase
VV1_RS12585	COG0308	aminopeptidase N
VV1_RS12600	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VV1_RS12605	COG1956	GAF domain-containing protein
VV1_RS12610	COG1132	(ABC) transporter
VV1_RS12615	COG2995	paraquat-inducible protein a
VV1_RS12620	COG3008	intermembrane lipid transfer
VV1_RS12625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VV1_RS12625	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VV1_RS12630	COG2996	Protein conserved in bacteria
VV1_RS12645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VV1_RS12655	COG3706	GGDEF domain
VV1_RS12660	COG1793	dna ligase
VV1_RS12665	COG1366	Belongs to the anti-sigma-factor antagonist family
VV1_RS12695	COG2204	response regulator
VV1_RS12740	COG0438	transferase activity, transferring glycosyl groups
VV1_RS12750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV1_RS12780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VV1_RS12785	COG0363	glucosamine-6-phosphate deaminase activity
VV1_RS12790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VV1_RS12795	COG4565	transcriptional regulatory protein
VV1_RS12800	COG3290	protein histidine kinase activity
VV1_RS12815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV1_RS12845	COG1115	amino acid carrier protein
VV1_RS12860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VV1_RS12865	COG0204	Acyl-transferase
VV1_RS12870	COG0348	domain, Protein
VV1_RS12875	COG0437	4 iron, 4 sulfur cluster binding
VV1_RS12885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV1_RS12890	COG4597	amino acid ABC transporter
VV1_RS12895	COG0765	amino acid transport
VV1_RS12900	COG1126	abc transporter atp-binding protein
VV1_RS12905	COG0670	Belongs to the BI1 family
VV1_RS12915	COG2920	part of a sulfur-relay system
VV1_RS12935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VV1_RS12960	COG3706	GGDEF domain
VV1_RS12970	COG0602	queuosine metabolic process
VV1_RS12975	COG0561	phosphatase activity
VV1_RS13015	COG2828	Protein conserved in bacteria
VV1_RS13020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VV1_RS13025	COG0372	Belongs to the citrate synthase family
VV1_RS13030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VV1_RS13040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VV1_RS13080	COG2197	response regulator
VV1_RS13090	COG0730	response to heat
VV1_RS13105	COG1653	transport
VV1_RS13110	COG1175	transmembrane transport
VV1_RS13115	COG0395	ABC-type sugar transport system, permease component
VV1_RS13125	COG1349	DNA-binding transcription factor activity
VV1_RS13130	COG0584	glycerophosphoryl diester phosphodiesterase
VV1_RS13145	COG1278	Cold shock
VV1_RS13185	COG0625	glutathione transferase activity
VV1_RS13195	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VV1_RS13205	COG2195	Cleaves the N-terminal amino acid of tripeptides
VV1_RS13220	COG3063	Type IV pilus biogenesis stability protein PilW
VV1_RS13235	COG1451	nucleotide metabolic process
VV1_RS13295	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VV1_RS13310	COG2925	Exonuclease
VV1_RS13315	COG1380	Effector of murein hydrolase LrgA
VV1_RS13320	COG1346	cytolysis
VV1_RS13330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VV1_RS13345	COG1643	Atp-dependent helicase
VV1_RS13350	COG0281	malic enzyme
VV1_RS13355	COG2949	membrane
VV1_RS13360	COG0471	metal ion transport
VV1_RS13375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VV1_RS13385	COG0492	ferredoxin-NADP+ reductase activity
VV1_RS13390	COG4988	ABC transporter
VV1_RS13395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VV1_RS13410	COG5002	protein histidine kinase activity
VV1_RS13410	COG5002	protein histidine kinase activity
VV1_RS13425	COG3070	regulator of competence-specific genes
VV1_RS13435	COG2431	L-lysine efflux transmembrane transporter activity
VV1_RS13445	COG0076	glutamate decarboxylase activity
VV1_RS13450	COG1737	Transcriptional regulator
VV1_RS13455	COG1979	alcohol dehydrogenase
VV1_RS13460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VV1_RS13465	COG2985	domain, Protein
VV1_RS13465	COG3273	potassium ion transport
VV1_RS13485	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VV1_RS13500	COG1136	(ABC) transporter
VV1_RS13505	COG0702	epimerase
VV1_RS13520	COG2814	Major facilitator Superfamily
VV1_RS13530	COG1061	Type III restriction enzyme res subunit
VV1_RS13545	COG2205	protein histidine kinase activity
VV1_RS13550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VV1_RS13575	COG3313	Fe-S protein
VV1_RS13585	COG4134	Bacterial extracellular solute-binding protein
VV1_RS13590	COG4135	transport system, permease component
VV1_RS13595	COG4136	ATPase activity
VV1_RS13600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VV1_RS13605	COG3604	Transcriptional regulator
VV1_RS13615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VV1_RS13625	COG0564	pseudouridine synthase activity
VV1_RS13635	COG0733	neurotransmitter:sodium symporter activity
VV1_RS13645	COG0626	cystathionine gamma-synthase activity
VV1_RS13650	COG2818	Glycosylase
VV1_RS13660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV1_RS13670	COG1983	PspC domain protein
VV1_RS13680	COG1842	Phage shock protein A
VV1_RS13685	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VV1_RS13710	COG4172	Belongs to the ABC transporter superfamily
VV1_RS13725	COG1227	inorganic diphosphatase activity
VV1_RS13760	COG3005	denitrification pathway
VV1_RS13765	COG4459	periplasmic nitrate reductase
VV1_RS13770	COG0390	transport system, permease component
VV1_RS13775	COG2116	formate transmembrane transporter activity
VV1_RS13795	COG0583	DNA-binding transcription factor activity
VV1_RS13800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VV1_RS13820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VV1_RS13830	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VV1_RS13855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VV1_RS13875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VV1_RS13880	COG1757	Na H antiporter
VV1_RS13885	COG2916	Histone family protein nucleoid-structuring protein H-NS
VV1_RS13890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV1_RS13905	COG2915	High frequency lysogenization protein hflD homolog
VV1_RS13910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VV1_RS13930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VV1_RS13945	COG1028	Short-chain dehydrogenase reductase Sdr
VV1_RS13955	COG0501	Belongs to the peptidase M48B family
VV1_RS13960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VV1_RS13975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VV1_RS13990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VV1_RS13995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VV1_RS14010	COG0686	Belongs to the AlaDH PNT family
VV1_RS14020	COG0583	DNA-binding transcription factor activity
VV1_RS14050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV1_RS14055	COG3108	Peptidase M15
VV1_RS14060	COG2989	Protein conserved in bacteria
VV1_RS14100	COG4608	Belongs to the ABC transporter superfamily
VV1_RS14105	COG0444	Belongs to the ABC transporter superfamily
VV1_RS14110	COG4166	transmembrane transport
VV1_RS14115	COG4239	(ABC) transporter, permease
VV1_RS14120	COG4174	ABC transporter (Permease)
VV1_RS14130	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VV1_RS14135	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VV1_RS14145	COG0539	negative regulation of cytoplasmic translation
VV1_RS14155	COG0616	signal peptide processing
VV1_RS14160	COG1028	Short-chain dehydrogenase reductase Sdr
VV1_RS14180	COG0835	chemotaxis
VV1_RS14180	COG0784	Response regulator, receiver
VV1_RS14185	COG1940	carbohydrate kinase activity
VV1_RS14190	COG0469	pyruvate kinase activity
VV1_RS14195	COG4667	esterase of the alpha-beta hydrolase superfamily
VV1_RS14205	COG0733	neurotransmitter:sodium symporter activity
VV1_RS14215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV1_RS14215	COG1263	PTS System
VV1_RS14220	COG0084	hydrolase, TatD family'
VV1_RS14230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VV1_RS14235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VV1_RS14250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV1_RS14270	COG0416	fatty acid biosynthetic process
VV1_RS14275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VV1_RS14280	COG1399	metal-binding, possibly nucleic acid-binding protein
VV1_RS14295	COG1530	ribonuclease E activity
VV1_RS14300	COG0659	secondary active sulfate transmembrane transporter activity
VV1_RS14305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VV1_RS14310	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VV1_RS14320	COG0572	uridine kinase
VV1_RS14325	COG0489	protein tyrosine kinase activity
VV1_RS14345	COG4235	cytochrome complex assembly
VV1_RS14345	COG3088	subunit of a heme lyase
VV1_RS14350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VV1_RS14355	COG1138	Cytochrome C-type biogenesis protein
VV1_RS14360	COG3301	Polysulphide reductase, NrfD
VV1_RS14365	COG0437	4 iron, 4 sulfur cluster binding
VV1_RS14370	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VV1_RS14375	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VV1_RS14400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VV1_RS14405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV1_RS14410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV1_RS14480	COG2197	response regulator
VV1_RS14485	COG0417	DNA replication proofreading
VV1_RS14490	COG5001	Diguanylate cyclase
VV1_RS14500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VV1_RS14520	COG0009	L-threonylcarbamoyladenylate synthase
VV1_RS14525	COG0613	PHP domain protein
VV1_RS14535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VV1_RS14540	COG0512	Glutamine amidotransferase of anthranilate synthase
VV1_RS14550	COG0134	indole-3-glycerol-phosphate synthase activity
VV1_RS14550	COG0135	phosphoribosylanthranilate isomerase activity
VV1_RS14555	COG0133	tryptophan synthase activity
VV1_RS14565	COG1301	dicarboxylic acid transport
VV1_RS14585	COG2350	Protein conserved in bacteria
VV1_RS14595	COG0435	Glutathione S-transferase
VV1_RS14605	COG0444	Belongs to the ABC transporter superfamily
VV1_RS14610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV1_RS14615	COG0601	transmembrane transport
VV1_RS14625	COG0314	molybdopterin synthase activity
VV1_RS14630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VV1_RS14640	COG0521	Mo-molybdopterin cofactor biosynthetic process
VV1_RS14650	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VV1_RS14655	COG2198	Histidine kinase
VV1_RS14660	COG2204	response regulator
VV1_RS14665	COG0556	nucleotide-excision repair
VV1_RS14680	COG4657	Part of a membrane complex involved in electron transport
VV1_RS14685	COG2878	Part of a membrane complex involved in electron transport
VV1_RS14690	COG4656	Part of a membrane complex involved in electron transport
VV1_RS14695	COG4658	electron transport chain
VV1_RS14700	COG4659	FMN binding
VV1_RS14705	COG4660	Part of a membrane complex involved in electron transport
VV1_RS14710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VV1_RS14715	COG0346	lactoylglutathione lyase activity
VV1_RS14725	COG2885	chlorophyll binding
VV1_RS14735	COG2056	Na+-H+ antiporter family
VV1_RS14745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VV1_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
VV1_RS14765	COG1454	alcohol dehydrogenase
VV1_RS14765	COG1012	belongs to the aldehyde dehydrogenase family
VV1_RS14770	COG2095	MarC family integral membrane protein
VV1_RS14775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV1_RS14785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VV1_RS14790	COG1757	Na H antiporter
VV1_RS14805	COG3081	Nucleoid-associated protein
VV1_RS14815	COG3083	sulfuric ester hydrolase activity
VV1_RS14825	COG0569	domain protein
VV1_RS14830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV1_RS14835	COG2731	YhcH YjgK YiaL family protein
VV1_RS14840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VV1_RS14850	COG0784	Response regulator, receiver
VV1_RS14850	COG2205	protein histidine kinase activity
VV1_RS14855	COG0123	including yeast histone deacetylase and acetoin utilization protein
VV1_RS14860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VV1_RS14865	COG0778	Nitroreductase
VV1_RS14870	COG1902	pentaerythritol trinitrate reductase activity
VV1_RS14870	COG0446	pyridine nucleotide-disulphide oxidoreductase
VV1_RS14875	COG0616	signal peptide processing
VV1_RS14880	COG0252	asparaginase activity
VV1_RS14885	COG3139	Protein of unknown function (DUF1315)
VV1_RS14900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VV1_RS14930	COG5001	Diguanylate cyclase
VV1_RS14945	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VV1_RS14950	COG1946	Acyl-CoA thioesterase
VV1_RS14960	COG1522	sequence-specific DNA binding
VV1_RS14965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VV1_RS14980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV1_RS14985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV1_RS15030	COG0318	PFAM AMP-dependent synthetase and ligase
VV1_RS15040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VV1_RS15045	COG0596	Alpha beta hydrolase
VV1_RS15055	COG1169	isochorismate synthase
VV1_RS15060	COG0436	Aminotransferase
VV1_RS15065	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VV1_RS15070	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VV1_RS15165	COG3547	Transposase (IS116 IS110 IS902 family)
VV1_RS15170	COG1566	PFAM secretion protein HlyD family protein
VV1_RS15180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VV1_RS15190	COG0745	RESPONSE REGULATOR receiver
VV1_RS15195	COG2205	protein histidine kinase activity
VV1_RS15195	COG0784	Response regulator, receiver
VV1_RS15465	COG2986	histidine ammonia-lyase
VV1_RS16050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VV1_RS16315	COG0772	Belongs to the SEDS family
VV1_RS16450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV1_RS16450	COG0301	tRNA thio-modification
VV1_RS16555	COG2252	PERMEase
VV1_RS16610	COG0047	phosphoribosylformylglycinamidine synthase activity
VV1_RS16610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VV1_RS16685	COG0443	Heat shock 70 kDa protein
VV1_RS17445	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VV1_RS17505	COG0069	glutamate synthase activity
VV1_RS17505	COG0070	glutamate synthase
VV1_RS17505	COG0067	glutamate synthase
VV1_RS17520	COG0067	glutamate synthase
VV1_RS17520	COG0069	glutamate synthase activity
VV1_RS17520	COG0070	glutamate synthase
VV1_RS17525	COG0070	glutamate synthase
VV1_RS17525	COG0069	glutamate synthase activity
VV1_RS17525	COG0067	glutamate synthase
VV1_RS17550	COG0069	glutamate synthase activity
VV1_RS17550	COG0070	glutamate synthase
VV1_RS17550	COG0067	glutamate synthase
VV1_RS17805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VV1_RS17805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VV1_RS18245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VV1_RS18445	COG3064	Membrane
VV1_RS18450	COG3064	Membrane
VV1_RS18870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VV1_RS19180	COG0514	ATP-dependent DNA helicase (RecQ)
VV1_RS19205	COG0210	DNA helicase
VV1_RS19460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VV1_RS19870	COG0129	dihydroxy-acid dehydratase activity
VV1_RS19945	COG0697	spore germination
VV1_RS20040	COG2200	EAL domain
VV1_RS20040	COG3287	FIST C domain
VV1_RS20040	COG2199	diguanylate cyclase activity
VV1_RS20265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VV1_RS20300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VV1_RS20415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VV1_RS20510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VV1_RS20775	COG0429	hydrolase of the alpha beta-hydrolase fold
VV1_RS20895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VV1_RS21090	COG0646	methionine synthase
VV1_RS21090	COG1410	methionine synthase
VV1_RS21590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VV1_RS21615	COG0481	GTPase activity
VV1_RS21645	COG3447	MASE1 domain protein
VV1_RS21645	COG5001	Diguanylate cyclase
VV1_RS21645	COG5002	protein histidine kinase activity
VV1_RS21710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VV1_RS21780	COG5016	pyruvate
VV1_RS21780	COG0511	ligase activity, forming carbon-carbon bonds
VV1_RS21820	COG2918	glutathione biosynthetic process
VV1_RS22130	COG4608	Belongs to the ABC transporter superfamily
VV1_RS22555	COG1609	Transcriptional regulator
VV1_RS22690	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VV1_RS22775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VV1_RS22840	COG1805	sodium ion transport
VV1_RS22965	COG1040	competence protein