locus-tag	class	description
FORC53_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC53_RS00010	COG0592	DNA-directed DNA polymerase activity
FORC53_RS00020	COG0187	DNA topoisomerase II activity
FORC53_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC53_RS00035	COG3977	Valine--pyruvate aminotransferase
FORC53_RS00045	COG0751	glycine-tRNA ligase activity
FORC53_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
FORC53_RS00055	COG2119	membrane
FORC53_RS00065	COG0425	Belongs to the sulfur carrier protein TusA family
FORC53_RS00080	COG0604	alcohol dehydrogenase
FORC53_RS00095	COG1739	Uncharacterized protein family UPF0029
FORC53_RS00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC53_RS00140	COG3335	DDE superfamily endonuclease
FORC53_RS00150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC53_RS00155	COG2960	long-chain fatty acid transporting porin activity
FORC53_RS00160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC53_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC53_RS00170	COG1309	transcriptional regulator
FORC53_RS00210	COG4172	Belongs to the ABC transporter superfamily
FORC53_RS00215	COG4166	transmembrane transport
FORC53_RS00220	COG0601	transmembrane transport
FORC53_RS00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC53_RS00260	COG0515	serine threonine protein kinase
FORC53_RS00260	COG2815	serine threonine protein kinase
FORC53_RS00270	COG0745	RESPONSE REGULATOR receiver
FORC53_RS00275	COG1609	Transcriptional regulator
FORC53_RS00280	COG0129	dihydroxy-acid dehydratase activity
FORC53_RS00285	COG3265	gluconokinase activity
FORC53_RS00295	COG0800	Aldolase
FORC53_RS00315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC53_RS00320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC53_RS00330	COG1522	sequence-specific DNA binding
FORC53_RS00335	COG5001	Diguanylate cyclase
FORC53_RS00335	COG5002	protein histidine kinase activity
FORC53_RS00355	COG0589	response to stress
FORC53_RS00360	COG1528	Iron-storage protein
FORC53_RS00370	COG2081	HI0933 family
FORC53_RS00380	COG2959	enzyme of heme biosynthesis
FORC53_RS00390	COG0181	hydroxymethylbilane synthase activity
FORC53_RS00395	COG3072	Adenylate cyclase
FORC53_RS00400	COG1965	Belongs to the frataxin family
FORC53_RS00410	COG0019	diaminopimelate decarboxylase activity
FORC53_RS00415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC53_RS00425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC53_RS00430	COG1011	Hydrolase
FORC53_RS00435	COG2199	diguanylate cyclase activity
FORC53_RS00435	COG3287	FIST C domain
FORC53_RS00435	COG2200	EAL domain
FORC53_RS00440	COG3148	PFAM DTW domain containing protein
FORC53_RS00455	COG0561	phosphatase activity
FORC53_RS00460	COG2267	carboxylic ester hydrolase activity
FORC53_RS00465	COG1280	lysine exporter protein (LysE YggA)
FORC53_RS00470	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC53_RS00475	COG0640	Transcriptional regulator
FORC53_RS00480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC53_RS00525	COG2095	MarC family integral membrane protein
FORC53_RS00535	COG0742	ribosomal rna small subunit methyltransferase
FORC53_RS00540	COG0552	protein localization to endoplasmic reticulum
FORC53_RS00545	COG2884	Cell division ATP-binding protein ftsE
FORC53_RS00550	COG2177	Part of the ABC transporter FtsEX involved in
FORC53_RS00560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC53_RS00570	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC53_RS00600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC53_RS00610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC53_RS00625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC53_RS00630	COG4206	TonB-dependent receptor
FORC53_RS00705	COG3335	DDE superfamily endonuclease
FORC53_RS00715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC53_RS00725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC53_RS00760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC53_RS00765	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC53_RS00780	COG0081	regulation of translation
FORC53_RS00785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC53_RS00790	COG0222	ribosome binding
FORC53_RS00795	COG0085	RNA polymerase activity
FORC53_RS00800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC53_RS00805	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC53_RS00825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC53_RS00830	COG1573	uracil-dna glycosylase
FORC53_RS00835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC53_RS00840	COG3068	Protein conserved in bacteria
FORC53_RS00845	COG1253	flavin adenine dinucleotide binding
FORC53_RS00860	COG0151	Belongs to the GarS family
FORC53_RS00865	COG0138	bifunctional purine biosynthesis protein purh
FORC53_RS00870	COG0789	Transcriptional regulator
FORC53_RS00875	COG0840	transmembrane signaling receptor activity
FORC53_RS00880	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC53_RS00890	COG2264	protein methyltransferase activity
FORC53_RS00895	COG0439	Biotin carboxylase
FORC53_RS00900	COG0511	ligase activity, forming carbon-carbon bonds
FORC53_RS00905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC53_RS00910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC53_RS00925	COG2814	Major facilitator Superfamily
FORC53_RS00930	COG2205	protein histidine kinase activity
FORC53_RS00930	COG2198	Histidine kinase
FORC53_RS00930	COG0784	Response regulator, receiver
FORC53_RS00950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC53_RS00960	COG2095	MarC family integral membrane protein
FORC53_RS00970	COG4232	protein-disulfide reductase activity
FORC53_RS00975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC53_RS00980	COG1027	Aspartate ammonia-lyase
FORC53_RS00990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC53_RS01000	COG2205	protein histidine kinase activity
FORC53_RS01005	COG0745	RESPONSE REGULATOR receiver
FORC53_RS01010	COG3678	ATP-independent chaperone mediated protein folding
FORC53_RS01020	COG0205	6-phosphofructokinase activity
FORC53_RS01025	COG0534	Mate efflux family protein
FORC53_RS01030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC53_RS01035	COG0459	protein refolding
FORC53_RS01045	COG1285	pathogenesis
FORC53_RS01050	COG1509	lysine 2,3-aminomutase activity
FORC53_RS01055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC53_RS01065	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC53_RS01070	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC53_RS01075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC53_RS01080	COG1053	succinate dehydrogenase
FORC53_RS01085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC53_RS01105	COG4942	peptidase
FORC53_RS01110	COG1045	serine acetyltransferase
FORC53_RS01115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC53_RS01120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC53_RS01125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC53_RS01135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC53_RS01145	COG0471	metal ion transport
FORC53_RS01150	COG0688	phosphatidylethanolamine metabolic process
FORC53_RS01155	COG1162	GTPase activity
FORC53_RS01160	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC53_RS01220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC53_RS01225	COG0802	atpase or kinase
FORC53_RS01230	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC53_RS01245	COG1923	regulation of RNA biosynthetic process
FORC53_RS01250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC53_RS01255	COG0330	HflC and HflK could
FORC53_RS01260	COG0330	HflC and HflK could
FORC53_RS01265	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC53_RS01270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC53_RS01275	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC53_RS01280	COG1017	nitric oxide dioxygenase activity
FORC53_RS01280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC53_RS01285	COG1959	2 iron, 2 sulfur cluster binding
FORC53_RS01290	COG0402	S-adenosylhomocysteine deaminase activity
FORC53_RS01295	COG0557	exoribonuclease II activity
FORC53_RS01300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC53_RS01330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC53_RS01350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC53_RS01355	COG3954	Phosphoribulokinase
FORC53_RS01360	COG3089	Belongs to the UPF0270 family
FORC53_RS01365	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC53_RS01375	COG0488	(ABC) transporter
FORC53_RS01380	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC53_RS01395	COG1047	Peptidyl-prolyl cis-trans
FORC53_RS01405	COG2900	Belongs to the SlyX family
FORC53_RS01415	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC53_RS01420	COG2964	Protein conserved in bacteria
FORC53_RS01430	COG2923	Belongs to the DsrF TusC family
FORC53_RS01435	COG2168	tRNA wobble position uridine thiolation
FORC53_RS01440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FORC53_RS01445	COG0049	tRNA binding
FORC53_RS01450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC53_RS01460	COG2906	2 iron, 2 sulfur cluster binding
FORC53_RS01470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC53_RS01475	COG0149	triose-phosphate isomerase activity
FORC53_RS01500	COG1494	fructose-1,6-bisphosphatase
FORC53_RS01510	COG3074	FtsZ-dependent cytokinesis
FORC53_RS01520	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC53_RS01525	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC53_RS01530	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC53_RS01540	COG1609	Transcriptional regulator
FORC53_RS01545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC53_RS01555	COG0281	malic enzyme
FORC53_RS01560	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
FORC53_RS01565	COG0626	cystathionine gamma-synthase activity
FORC53_RS01570	COG0527	aspartate kinase activity
FORC53_RS01570	COG0460	homoserine dehydrogenase
FORC53_RS01575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC53_RS01585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC53_RS01590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC53_RS01600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC53_RS01605	COG0137	argininosuccinate synthase activity
FORC53_RS01610	COG0165	Argininosuccinate lyase
FORC53_RS01610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC53_RS01625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC53_RS01655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC53_RS01660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC53_RS01670	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC53_RS01675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC53_RS01680	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC53_RS01685	COG2965	DNA replication, synthesis of RNA primer
FORC53_RS01695	COG0359	binds to the 23S rRNA
FORC53_RS01710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC53_RS01720	COG0432	Pfam Uncharacterised protein family UPF0047
FORC53_RS01735	COG0735	belongs to the Fur family
FORC53_RS01840	COG3385	transposase activity
FORC53_RS01850	COG0646	methionine synthase
FORC53_RS01850	COG1410	methionine synthase
FORC53_RS01855	COG0527	aspartate kinase activity
FORC53_RS01865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC53_RS01875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC53_RS01895	COG2200	EAL domain
FORC53_RS01895	COG2199	diguanylate cyclase activity
FORC53_RS01920	COG3267	Type II secretory pathway component ExeA
FORC53_RS01920	COG3409	Peptidoglycan-binding domain 1 protein
FORC53_RS01930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC53_RS01935	COG1459	type II secretion system
FORC53_RS01945	COG2165	general secretion pathway protein
FORC53_RS01950	COG2165	general secretion pathway protein
FORC53_RS01980	COG1077	Cell shape determining protein MreB Mrl
FORC53_RS01990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC53_RS01995	COG0424	maF-like protein
FORC53_RS02005	COG3164	Protein of unknown function
FORC53_RS02010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC53_RS02015	COG0312	modulator of DNA gyrase
FORC53_RS02020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC53_RS02035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC53_RS02040	COG0251	oxidation-reduction process
FORC53_RS02045	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC53_RS02075	COG0456	acetyltransferase
FORC53_RS02085	COG4269	membrane
FORC53_RS02095	COG0525	valine-tRNA ligase activity
FORC53_RS02100	COG2927	DNA polymerase III (CHI subunit)
FORC53_RS02105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC53_RS02110	COG0795	lipopolysaccharide-transporting ATPase activity
FORC53_RS02115	COG0795	lipopolysaccharide-transporting ATPase activity
FORC53_RS02130	COG0726	polysaccharide deacetylase
FORC53_RS02135	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC53_RS02145	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC53_RS02150	COG1486	melibiose metabolic process
FORC53_RS02160	COG1609	Transcriptional regulator
FORC53_RS02170	COG3437	response regulator, receiver
FORC53_RS02285	COG0741	lytic transglycosylase activity
FORC53_RS02290	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC53_RS02300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC53_RS02305	COG2066	Belongs to the glutaminase family
FORC53_RS02315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC53_RS02320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC53_RS02330	COG1872	DUF167
FORC53_RS02335	COG0762	integral membrane protein
FORC53_RS02340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC53_RS02345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC53_RS02360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC53_RS02365	COG1678	Uncharacterized ACR, COG1678
FORC53_RS02375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC53_RS02380	COG2356	endonuclease I
FORC53_RS02395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC53_RS02415	COG0126	phosphoglycerate kinase activity
FORC53_RS02420	COG0191	fructose-bisphosphate aldolase activity
FORC53_RS02425	COG0668	transmembrane transport
FORC53_RS02430	COG1279	arginine transmembrane transporter activity
FORC53_RS02445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC53_RS02455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC53_RS02465	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC53_RS02470	COG3079	Belongs to the UPF0149 family
FORC53_RS02475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC53_RS02480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC53_RS02495	COG0354	folic acid binding
FORC53_RS02510	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC53_RS02515	COG1595	DNA-templated transcription, initiation
FORC53_RS02530	COG3086	response to oxidative stress
FORC53_RS02535	COG0481	GTPase activity
FORC53_RS02550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC53_RS02555	COG1381	Involved in DNA repair and RecF pathway recombination
FORC53_RS02560	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC53_RS02565	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC53_RS02580	COG5001	Diguanylate cyclase
FORC53_RS02585	COG3850	Histidine kinase
FORC53_RS02585	COG3437	response regulator, receiver
FORC53_RS02585	COG2205	protein histidine kinase activity
FORC53_RS02585	COG4999	Histidine kinase
FORC53_RS02595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC53_RS02600	COG3956	TIGRFAM MazG family protein
FORC53_RS02605	COG0504	CTP synthase activity
FORC53_RS02615	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC53_RS02625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC53_RS02640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC53_RS02645	COG1388	LysM domain
FORC53_RS02645	COG4942	peptidase
FORC53_RS02650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC53_RS02655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC53_RS02665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC53_RS02685	COG3547	Transposase (IS116 IS110 IS902 family)
FORC53_RS02715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC53_RS02720	COG2274	protein secretion by the type I secretion system
FORC53_RS02760	COG0527	aspartate kinase activity
FORC53_RS02765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FORC53_RS02810	COG3630	sodium ion export across plasma membrane
FORC53_RS02815	COG5016	pyruvate
FORC53_RS02815	COG0511	ligase activity, forming carbon-carbon bonds
FORC53_RS02820	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC53_RS02830	COG1238	metal cluster binding
FORC53_RS02835	COG0612	Peptidase, M16
FORC53_RS02850	COG1854	S-ribosylhomocysteine lyase activity
FORC53_RS02855	COG4536	flavin adenine dinucleotide binding
FORC53_RS02860	COG4137	Cytochrome C assembly protein
FORC53_RS02865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC53_RS02870	COG0228	four-way junction DNA binding
FORC53_RS02875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC53_RS02880	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC53_RS02885	COG0335	large ribosomal subunit rRNA binding
FORC53_RS02910	COG1459	type II secretion system
FORC53_RS02915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC53_RS02930	COG3023	N-Acetylmuramoyl-L-alanine amidase
FORC53_RS02935	COG2186	Transcriptional regulator
FORC53_RS02940	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC53_RS02945	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC53_RS02950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC53_RS02965	COG0288	reversible hydration of carbon dioxide
FORC53_RS02970	COG0659	secondary active sulfate transmembrane transporter activity
FORC53_RS02975	COG1131	(ABC) transporter
FORC53_RS02980	COG0842	Transport permease protein
FORC53_RS02990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC53_RS02995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC53_RS03005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC53_RS03010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC53_RS03015	COG1489	DNA binding
FORC53_RS03020	COG1643	Atp-dependent helicase
FORC53_RS03025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC53_RS03030	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC53_RS03035	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC53_RS03040	COG1929	Belongs to the glycerate kinase type-1 family
FORC53_RS03045	COG2610	gluconate transmembrane transporter activity
FORC53_RS03055	COG3112	Uncharacterised protein family (UPF0231)
FORC53_RS03060	COG0347	Belongs to the P(II) protein family
FORC53_RS03065	COG0004	ammonium transporteR
FORC53_RS03070	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC53_RS03085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC53_RS03100	COG2971	BadF BadG BcrA BcrD
FORC53_RS03110	COG4608	Belongs to the ABC transporter superfamily
FORC53_RS03115	COG0444	Belongs to the ABC transporter superfamily
FORC53_RS03120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC53_RS03125	COG0601	transmembrane transport
FORC53_RS03135	COG2205	protein histidine kinase activity
FORC53_RS03135	COG0784	Response regulator, receiver
FORC53_RS03145	COG0628	permease
FORC53_RS03170	COG0739	heme binding
FORC53_RS03175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC53_RS03180	COG2832	Protein of unknown function (DUF454)
FORC53_RS03185	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC53_RS03190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC53_RS03205	COG1534	Rna-binding protein
FORC53_RS03210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC53_RS03215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC53_RS03220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC53_RS03225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC53_RS03230	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC53_RS03245	COG0779	Required for maturation of 30S ribosomal subunits
FORC53_RS03250	COG0195	Participates in both transcription termination and antitermination
FORC53_RS03260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC53_RS03265	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC53_RS03270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC53_RS03275	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC53_RS03290	COG0534	Mate efflux family protein
FORC53_RS03295	COG0826	peptidase U32
FORC53_RS03300	COG0826	peptidase U32
FORC53_RS03310	COG3154	lipid carrier protein
FORC53_RS03315	COG3153	acetyltransferase
FORC53_RS03325	COG0456	acetyltransferase
FORC53_RS03335	COG3706	GGDEF domain
FORC53_RS03345	COG0084	hydrolase, TatD family'
FORC53_RS03350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC53_RS03355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC53_RS03360	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC53_RS03365	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC53_RS03370	COG0813	purine-nucleoside phosphorylase activity
FORC53_RS03380	COG0560	Phosphoserine phosphatase
FORC53_RS03390	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC53_RS03395	COG3447	MASE1 domain protein
FORC53_RS03395	COG5001	Diguanylate cyclase
FORC53_RS03395	COG5002	protein histidine kinase activity
FORC53_RS03410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC53_RS03415	COG0583	DNA-binding transcription factor activity
FORC53_RS03425	COG1022	Amp-dependent synthetase and ligase
FORC53_RS03460	COG4964	Belongs to the GSP D family
FORC53_RS03510	COG2059	Chromate
FORC53_RS03515	COG0583	DNA-binding transcription factor activity
FORC53_RS03525	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FORC53_RS03525	COG3408	Glycogen debranching enzyme
FORC53_RS03530	COG0531	amino acid
FORC53_RS03535	COG0531	amino acid
FORC53_RS03540	COG2731	YhcH YjgK YiaL family protein
FORC53_RS03545	COG3250	beta-galactosidase activity
FORC53_RS03555	COG1609	Transcriptional regulator
FORC53_RS03560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC53_RS03575	COG2017	converts alpha-aldose to the beta-anomer
FORC53_RS03580	COG0840	transmembrane signaling receptor activity
FORC53_RS03590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC53_RS03605	COG0189	ligase activity
FORC53_RS03605	COG0569	domain protein
FORC53_RS03620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC53_RS03625	COG1349	DNA-binding transcription factor activity
FORC53_RS03630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC53_RS03635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC53_RS03640	COG2171	N-acyltransferase activity
FORC53_RS03645	COG3141	response to X-ray
FORC53_RS03660	COG3083	sulfuric ester hydrolase activity
FORC53_RS03665	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC53_RS03670	COG1074	ATP-dependent DNA helicase activity
FORC53_RS03675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC53_RS03695	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC53_RS03700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC53_RS03705	COG2166	iron-sulfur cluster assembly
FORC53_RS03715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC53_RS03720	COG0693	protein deglycase activity
FORC53_RS03725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC53_RS03730	COG3248	Nucleoside-binding outer membrane protein
FORC53_RS03740	COG1595	DNA-templated transcription, initiation
FORC53_RS03750	COG2211	Major facilitator Superfamily
FORC53_RS03765	COG2813	Specifically methylates the guanine in position
FORC53_RS03770	COG0271	Belongs to the BolA IbaG family
FORC53_RS03775	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC53_RS03780	COG1805	sodium ion transport
FORC53_RS03785	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC53_RS03795	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC53_RS03800	COG2871	sodium ion transport
FORC53_RS03805	COG1477	protein flavinylation
FORC53_RS03820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC53_RS03825	COG0514	ATP-dependent DNA helicase (RecQ)
FORC53_RS03840	COG0733	neurotransmitter:sodium symporter activity
FORC53_RS03865	COG1720	tRNA m6t6A37 methyltransferase activity
FORC53_RS03870	COG0254	rRNA binding
FORC53_RS03880	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC53_RS03900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC53_RS03940	COG3098	single-species biofilm formation
FORC53_RS03955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC53_RS03960	COG0024	Methionine aminopeptidase
FORC53_RS03965	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC53_RS03970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC53_RS03975	COG0528	UMP kinase activity
FORC53_RS03980	COG0233	cytoplasmic translational termination
FORC53_RS03985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC53_RS03990	COG0575	Belongs to the CDS family
FORC53_RS03995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC53_RS04000	COG0750	zinc metalloprotease
FORC53_RS04005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC53_RS04010	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC53_RS04015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC53_RS04020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC53_RS04025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC53_RS04030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC53_RS04035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC53_RS04040	COG0587	DNA-directed DNA polymerase activity
FORC53_RS04045	COG0825	malonyl-CoA metabolic process
FORC53_RS04060	COG0347	Belongs to the P(II) protein family
FORC53_RS04065	COG3021	interspecies interaction between organisms
FORC53_RS04075	COG0741	lytic transglycosylase activity
FORC53_RS04075	COG1388	LysM domain
FORC53_RS04080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC53_RS04085	COG2226	methyltransferase
FORC53_RS04090	COG0328	RNA-DNA hybrid ribonuclease activity
FORC53_RS04105	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC53_RS04120	COG1960	acyl-CoA dehydrogenase activity
FORC53_RS04130	COG0121	glutamine amidotransferase
FORC53_RS04135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC53_RS04140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC53_RS04145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC53_RS04150	COG2233	PERMEase
FORC53_RS04170	COG1393	Belongs to the ArsC family
FORC53_RS04175	COG4783	chaperone-mediated protein folding
FORC53_RS04190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC53_RS04195	COG2716	regulation of RNA biosynthetic process
FORC53_RS04200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC53_RS04205	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FORC53_RS04225	COG1393	Belongs to the ArsC family
FORC53_RS04250	COG2837	iron assimilation
FORC53_RS04255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC53_RS04260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC53_RS04265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC53_RS04270	COG1334	flagellar protein FlaG
FORC53_RS04275	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC53_RS04285	COG1516	flagellar protein fliS
FORC53_RS04305	COG1677	Flagellar hook-basal body complex protein FliE
FORC53_RS04315	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC53_RS04340	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC53_RS04365	COG1987	bacterial-type flagellum assembly
FORC53_RS04370	COG1684	flagellar biosynthetic protein fliR
FORC53_RS04405	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC53_RS04410	COG0784	Response regulator, receiver
FORC53_RS04410	COG0643	Histidine kinase
FORC53_RS04410	COG2198	Histidine kinase
FORC53_RS04420	COG1192	Involved in chromosome partitioning
FORC53_RS04430	COG0835	chemotaxis
FORC53_RS04440	COG4133	protoheme IX ABC transporter activity
FORC53_RS04445	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC53_RS04450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC53_RS04455	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC53_RS04460	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC53_RS04465	COG1138	Cytochrome C-type biogenesis protein
FORC53_RS04470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC53_RS04475	COG3088	subunit of a heme lyase
FORC53_RS04475	COG4235	cytochrome complex assembly
FORC53_RS04485	COG2853	Lipoprotein
FORC53_RS04490	COG2067	long-chain fatty acid transport protein
FORC53_RS04495	COG2067	long-chain fatty acid transport protein
FORC53_RS04510	COG0183	Belongs to the thiolase family
FORC53_RS04520	COG1025	Belongs to the peptidase M16 family
FORC53_RS04530	COG2062	phosphohistidine phosphatase, SixA
FORC53_RS04535	COG2840	Smr protein MutS2
FORC53_RS04540	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC53_RS04550	COG2860	membrane
FORC53_RS04555	COG3101	peptidyl-lysine hydroxylation
FORC53_RS04565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC53_RS04565	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC53_RS04570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC53_RS04585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC53_RS04595	COG0101	tRNA pseudouridine synthase activity
FORC53_RS04600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC53_RS04605	COG0285	dihydrofolate synthase activity
FORC53_RS04610	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC53_RS04615	COG1286	toxin biosynthetic process
FORC53_RS04620	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC53_RS04625	COG0583	DNA-binding transcription factor activity
FORC53_RS04630	COG0745	RESPONSE REGULATOR receiver
FORC53_RS04640	COG2832	Protein of unknown function (DUF454)
FORC53_RS04645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC53_RS04655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC53_RS04660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC53_RS04675	COG2205	protein histidine kinase activity
FORC53_RS04680	COG0745	RESPONSE REGULATOR receiver
FORC53_RS04695	COG2983	Belongs to the UPF0260 family
FORC53_RS04705	COG0346	lactoylglutathione lyase activity
FORC53_RS04715	COG1785	Belongs to the alkaline phosphatase family
FORC53_RS04730	COG2226	methyltransferase
FORC53_RS04735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC53_RS04770	COG0732	type I restriction modification DNA specificity domain
FORC53_RS04860	COG1396	sequence-specific DNA binding
FORC53_RS04865	COG3550	peptidyl-serine autophosphorylation
FORC53_RS04875	COG2239	Acts as a magnesium transporter
FORC53_RS04880	COG2199	diguanylate cyclase activity
FORC53_RS04880	COG2203	Gaf domain
FORC53_RS04900	COG3710	Transcriptional regulator
FORC53_RS04905	COG0531	amino acid
FORC53_RS04910	COG1982	Orn Lys Arg decarboxylase major
FORC53_RS04915	COG3706	GGDEF domain
FORC53_RS04920	COG0617	tRNA 3'-terminal CCA addition
FORC53_RS04920	COG0517	IMP dehydrogenase activity
FORC53_RS04920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FORC53_RS04945	COG0537	adenosine 5'-monophosphoramidase activity
FORC53_RS04975	COG1252	NADH dehydrogenase
FORC53_RS04990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC53_RS05000	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC53_RS05005	COG1136	(ABC) transporter
FORC53_RS05010	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC53_RS05020	COG0658	competence protein
FORC53_RS05020	COG2333	competence protein COMEC
FORC53_RS05025	COG1132	(ABC) transporter
FORC53_RS05030	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC53_RS05035	COG2835	tetraacyldisaccharide 4'-kinase activity
FORC53_RS05040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC53_RS05045	COG2199	diguanylate cyclase activity
FORC53_RS05050	COG2719	SpoVR family
FORC53_RS05055	COG2718	Belongs to the UPF0229 family
FORC53_RS05060	COG2766	serine protein kinase
FORC53_RS05065	COG3013	Belongs to the UPF0304 family
FORC53_RS05075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC53_RS05090	COG1882	Formate acetyltransferase
FORC53_RS05130	COG0708	Exodeoxyribonuclease III
FORC53_RS05135	COG0840	transmembrane signaling receptor activity
FORC53_RS05145	COG3923	Primosomal replication protein n
FORC53_RS05155	COG1199	ATP-dependent helicase activity
FORC53_RS05160	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC53_RS05180	COG1278	Cold shock
FORC53_RS05185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC53_RS05190	COG0542	response to heat
FORC53_RS05195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC53_RS05200	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC53_RS05215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC53_RS05230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC53_RS05240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC53_RS05245	COG0297	glycogen (starch) synthase activity
FORC53_RS05265	COG3070	regulator of competence-specific genes
FORC53_RS05270	COG1609	Transcriptional regulator
FORC53_RS05275	COG3381	protein complex oligomerization
FORC53_RS05280	COG0745	RESPONSE REGULATOR receiver
FORC53_RS05285	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC53_RS05290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC53_RS05295	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC53_RS05300	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC53_RS05305	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC53_RS05335	COG4067	protein conserved in archaea
FORC53_RS05335	COG0189	ligase activity
FORC53_RS05340	COG0500	methyltransferase
FORC53_RS05345	COG4106	trans-aconitate 2-methyltransferase activity
FORC53_RS05355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC53_RS05365	COG0840	transmembrane signaling receptor activity
FORC53_RS05370	COG0632	four-way junction helicase activity
FORC53_RS05375	COG2255	four-way junction helicase activity
FORC53_RS05380	COG1271	oxidase subunit
FORC53_RS05385	COG1294	oxidase, subunit
FORC53_RS05390	COG4890	Cyd operon protein YbgT
FORC53_RS05400	COG0824	Thioesterase
FORC53_RS05405	COG0811	peptide transport
FORC53_RS05420	COG0823	Involved in the tonB-independent uptake of proteins
FORC53_RS05425	COG2885	chlorophyll binding
FORC53_RS05430	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC53_RS05435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC53_RS05445	COG3766	membrane
FORC53_RS05455	COG0754	glutathionylspermidine amidase activity
FORC53_RS05465	COG2205	protein histidine kinase activity
FORC53_RS05465	COG0784	Response regulator, receiver
FORC53_RS05570	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FORC53_RS05585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC53_RS05595	COG1349	DNA-binding transcription factor activity
FORC53_RS05600	COG0738	Major facilitator superfamily
FORC53_RS05605	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
FORC53_RS05610	COG1070	Carbohydrate kinase
FORC53_RS05615	COG4154	Belongs to the RbsD FucU family
FORC53_RS05620	COG0235	Class ii aldolase
FORC53_RS05625	COG1454	alcohol dehydrogenase
FORC53_RS05630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC53_RS05635	COG0861	Integral membrane protein TerC family
FORC53_RS05660	COG2207	Transcriptional regulator
FORC53_RS05680	COG1032	radical SAM domain protein
FORC53_RS05705	COG0583	DNA-binding transcription factor activity
FORC53_RS05715	COG0280	phosphate acetyltransferase
FORC53_RS05715	COG0857	belongs to the CobB CobQ family
FORC53_RS05720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC53_RS05725	COG3092	negative regulation of chromosome organization
FORC53_RS05735	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC53_RS05745	COG0366	Alpha amylase catalytic
FORC53_RS05760	COG0653	protein targeting
FORC53_RS05775	COG2186	Transcriptional regulator
FORC53_RS05790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC53_RS05815	COG1846	Transcriptional regulator
FORC53_RS05820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC53_RS05845	COG1448	Aminotransferase
FORC53_RS05850	COG2770	Histidine kinase
FORC53_RS05850	COG3437	response regulator, receiver
FORC53_RS05865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC53_RS05875	COG0017	Asparaginyl-tRNA synthetase
FORC53_RS05880	COG0840	transmembrane signaling receptor activity
FORC53_RS05885	COG0720	synthase
FORC53_RS05895	COG2200	EAL domain
FORC53_RS05900	COG1760	l-serine dehydratase
FORC53_RS05905	COG0814	amino acid
FORC53_RS05910	COG0494	nUDIX hydrolase
FORC53_RS05920	COG0784	Response regulator, receiver
FORC53_RS05920	COG2205	protein histidine kinase activity
FORC53_RS05930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC53_RS05945	COG3106	COG3106 Predicted ATPase
FORC53_RS05950	COG3768	UPF0283 membrane protein
FORC53_RS05955	COG3283	Transcriptional regulator of aromatic amino acids metabolism
FORC53_RS05960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC53_RS05975	COG0471	metal ion transport
FORC53_RS05980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC53_RS05980	COG4191	Histidine kinase
FORC53_RS05990	COG3706	GGDEF domain
FORC53_RS06010	COG3300	MHYT domain
FORC53_RS06010	COG5001	Diguanylate cyclase
FORC53_RS06015	COG1328	CTP reductase activity
FORC53_RS06020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC53_RS06025	COG0583	DNA-binding transcription factor activity
FORC53_RS06040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC53_RS06045	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC53_RS06055	COG1597	lipid kinase activity
FORC53_RS06060	COG0814	amino acid
FORC53_RS06075	COG0783	Belongs to the Dps family
FORC53_RS06090	COG1132	(ABC) transporter
FORC53_RS06095	COG1132	(ABC) transporter
FORC53_RS06100	COG1115	amino acid carrier protein
FORC53_RS06115	COG1596	polysaccharide export
FORC53_RS06140	COG0438	transferase activity, transferring glycosyl groups
FORC53_RS06145	COG0297	glycogen (starch) synthase activity
FORC53_RS06145	COG0438	transferase activity, transferring glycosyl groups
FORC53_RS06160	COG2165	general secretion pathway protein
FORC53_RS06185	COG0443	Heat shock 70 kDa protein
FORC53_RS06200	COG3706	GGDEF domain
FORC53_RS06220	COG3713	MltA-interacting MipA family protein
FORC53_RS06250	COG4964	Belongs to the GSP D family
FORC53_RS06260	COG2894	cell division
FORC53_RS06300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC53_RS06315	COG1643	Atp-dependent helicase
FORC53_RS06340	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC53_RS06350	COG2814	Major facilitator Superfamily
FORC53_RS06365	COG0840	transmembrane signaling receptor activity
FORC53_RS06370	COG0010	Belongs to the arginase family
FORC53_RS06375	COG1166	arginine decarboxylase activity
FORC53_RS06440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC53_RS06465	COG0776	regulation of translation
FORC53_RS06475	COG0500	methyltransferase
FORC53_RS06480	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC53_RS06485	COG0295	cytidine deaminase activity
FORC53_RS06500	COG2885	chlorophyll binding
FORC53_RS06515	COG0277	FAD linked oxidase domain protein
FORC53_RS06515	COG0247	lactate metabolic process
FORC53_RS06520	COG2020	methyltransferase activity
FORC53_RS06525	COG5640	endopeptidase activity
FORC53_RS06535	COG2986	histidine ammonia-lyase
FORC53_RS06550	COG1228	amidohydrolase
FORC53_RS06560	COG4326	sporulation control protein
FORC53_RS06580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC53_RS06725	COG2944	sequence-specific DNA binding
FORC53_RS06820	COG3738	Protein conserved in bacteria
FORC53_RS06995	COG3738	Protein conserved in bacteria
FORC53_RS07020	COG1942	4-Oxalocrotonate Tautomerase
FORC53_RS07130	COG1280	lysine exporter protein (LysE YggA)
FORC53_RS07245	COG0251	oxidation-reduction process
FORC53_RS07440	COG4628	conserved protein (DUF2132)
FORC53_RS07465	COG0384	phenazine biosynthesis protein PhzF
FORC53_RS07515	COG4628	conserved protein (DUF2132)
FORC53_RS07860	COG0625	glutathione transferase activity
FORC53_RS07970	COG0456	acetyltransferase
FORC53_RS07975	COG0384	phenazine biosynthesis protein PhzF
FORC53_RS08015	COG0251	oxidation-reduction process
FORC53_RS08175	COG3152	Membrane
FORC53_RS08235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC53_RS08285	COG4628	conserved protein (DUF2132)
FORC53_RS08335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC53_RS08385	COG2801	Transposase and inactivated derivatives
FORC53_RS08420	COG0534	Mate efflux family protein
FORC53_RS08425	COG0307	riboflavin synthase, alpha
FORC53_RS08445	COG3706	GGDEF domain
FORC53_RS08455	COG0791	NLP P60 protein
FORC53_RS08460	COG0840	transmembrane signaling receptor activity
FORC53_RS08470	COG3148	PFAM DTW domain containing protein
FORC53_RS08475	COG1940	carbohydrate kinase activity
FORC53_RS08490	COG0746	molybdenum cofactor guanylyltransferase activity
FORC53_RS08495	COG3842	ATPase activity
FORC53_RS08500	COG4662	Binding-protein-dependent transport system inner membrane component
FORC53_RS08510	COG2204	response regulator
FORC53_RS08515	COG3852	Histidine kinase
FORC53_RS08530	COG0488	(ABC) transporter
FORC53_RS08535	COG0840	transmembrane signaling receptor activity
FORC53_RS08540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC53_RS08570	COG0243	molybdopterin cofactor binding
FORC53_RS08570	COG3383	formate dehydrogenase (NAD+) activity
FORC53_RS08575	COG0437	4 iron, 4 sulfur cluster binding
FORC53_RS08615	COG0004	ammonium transporteR
FORC53_RS08620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC53_RS08625	COG3385	transposase activity
FORC53_RS08630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC53_RS08640	COG1177	transmembrane transport
FORC53_RS08645	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC53_RS08650	COG3842	ATPase activity
FORC53_RS08660	COG2992	FlgJ-related protein
FORC53_RS08670	COG0037	tRNA processing
FORC53_RS08675	COG0589	response to stress
FORC53_RS08680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC53_RS08695	COG2217	Heavy metal translocating P-type atpase
FORC53_RS08705	COG2010	Cytochrome c
FORC53_RS08720	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC53_RS08790	COG4128	Pfam Zonular occludens toxin
FORC53_RS08815	COG3120	sequence-specific DNA binding
FORC53_RS08820	COG1067	ATP-dependent peptidase activity
FORC53_RS08825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC53_RS08840	COG0488	(ABC) transporter
FORC53_RS08850	COG0116	Belongs to the methyltransferase superfamily
FORC53_RS08850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC53_RS08865	COG2902	Dehydrogenase
FORC53_RS08875	COG0308	aminopeptidase N
FORC53_RS08890	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FORC53_RS08895	COG1956	GAF domain-containing protein
FORC53_RS08900	COG1132	(ABC) transporter
FORC53_RS08905	COG2995	paraquat-inducible protein a
FORC53_RS08910	COG3008	intermembrane lipid transfer
FORC53_RS08915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC53_RS08915	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FORC53_RS08920	COG2996	Protein conserved in bacteria
FORC53_RS08935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC53_RS08945	COG3706	GGDEF domain
FORC53_RS08950	COG1793	dna ligase
FORC53_RS08955	COG1366	Belongs to the anti-sigma-factor antagonist family
FORC53_RS08985	COG2204	response regulator
FORC53_RS09030	COG0438	transferase activity, transferring glycosyl groups
FORC53_RS09040	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC53_RS09080	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC53_RS09085	COG0363	glucosamine-6-phosphate deaminase activity
FORC53_RS09090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC53_RS09095	COG4565	transcriptional regulatory protein
FORC53_RS09100	COG3290	protein histidine kinase activity
FORC53_RS09115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC53_RS09155	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC53_RS09160	COG0204	Acyl-transferase
FORC53_RS09165	COG0348	domain, Protein
FORC53_RS09170	COG0437	4 iron, 4 sulfur cluster binding
FORC53_RS09180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC53_RS09185	COG4597	amino acid ABC transporter
FORC53_RS09190	COG0765	amino acid transport
FORC53_RS09195	COG1126	abc transporter atp-binding protein
FORC53_RS09200	COG0670	Belongs to the BI1 family
FORC53_RS09210	COG2920	part of a sulfur-relay system
FORC53_RS09225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC53_RS09340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC53_RS09345	COG0602	queuosine metabolic process
FORC53_RS09350	COG0561	phosphatase activity
FORC53_RS09405	COG2828	Protein conserved in bacteria
FORC53_RS09415	COG0372	Belongs to the citrate synthase family
FORC53_RS09420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC53_RS09430	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC53_RS09470	COG2197	response regulator
FORC53_RS09480	COG0730	response to heat
FORC53_RS09495	COG1653	transport
FORC53_RS09500	COG1175	transmembrane transport
FORC53_RS09505	COG0395	ABC-type sugar transport system, permease component
FORC53_RS09510	COG3842	ATPase activity
FORC53_RS09515	COG1349	DNA-binding transcription factor activity
FORC53_RS09520	COG0584	glycerophosphoryl diester phosphodiesterase
FORC53_RS09535	COG1278	Cold shock
FORC53_RS09575	COG0625	glutathione transferase activity
FORC53_RS09585	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC53_RS09595	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC53_RS09610	COG3063	Type IV pilus biogenesis stability protein PilW
FORC53_RS09625	COG1451	nucleotide metabolic process
FORC53_RS09655	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC53_RS09665	COG2988	succinylglutamate desuccinylase activity
FORC53_RS09685	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC53_RS09700	COG2925	Exonuclease
FORC53_RS09705	COG1380	Effector of murein hydrolase LrgA
FORC53_RS09710	COG1346	cytolysis
FORC53_RS09720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC53_RS09735	COG1643	Atp-dependent helicase
FORC53_RS09740	COG0281	malic enzyme
FORC53_RS09745	COG2949	membrane
FORC53_RS09750	COG0471	metal ion transport
FORC53_RS09775	COG0492	ferredoxin-NADP+ reductase activity
FORC53_RS09780	COG4988	ABC transporter
FORC53_RS09785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC53_RS09800	COG5002	protein histidine kinase activity
FORC53_RS09800	COG5002	protein histidine kinase activity
FORC53_RS09815	COG3070	regulator of competence-specific genes
FORC53_RS09825	COG2431	L-lysine efflux transmembrane transporter activity
FORC53_RS09835	COG0076	glutamate decarboxylase activity
FORC53_RS09840	COG1737	Transcriptional regulator
FORC53_RS09845	COG1979	alcohol dehydrogenase
FORC53_RS09850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC53_RS09855	COG3273	potassium ion transport
FORC53_RS09855	COG2985	domain, Protein
FORC53_RS09860	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC53_RS09875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC53_RS09890	COG1136	(ABC) transporter
FORC53_RS09895	COG0702	epimerase
FORC53_RS09910	COG2814	Major facilitator Superfamily
FORC53_RS09920	COG1061	Type III restriction enzyme res subunit
FORC53_RS09935	COG2205	protein histidine kinase activity
FORC53_RS09940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC53_RS09970	COG3313	Fe-S protein
FORC53_RS09980	COG4134	Bacterial extracellular solute-binding protein
FORC53_RS09985	COG4135	transport system, permease component
FORC53_RS09990	COG4136	ATPase activity
FORC53_RS09995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC53_RS10000	COG3604	Transcriptional regulator
FORC53_RS10005	COG1151	hydroxylamine reductase activity
FORC53_RS10010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC53_RS10020	COG0564	pseudouridine synthase activity
FORC53_RS10030	COG0733	neurotransmitter:sodium symporter activity
FORC53_RS10040	COG0626	cystathionine gamma-synthase activity
FORC53_RS10045	COG2818	Glycosylase
FORC53_RS10065	COG1983	PspC domain protein
FORC53_RS10075	COG1842	Phage shock protein A
FORC53_RS10080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC53_RS10105	COG4172	Belongs to the ABC transporter superfamily
FORC53_RS10120	COG1227	inorganic diphosphatase activity
FORC53_RS10155	COG0243	molybdopterin cofactor binding
FORC53_RS10160	COG3005	denitrification pathway
FORC53_RS10165	COG4459	periplasmic nitrate reductase
FORC53_RS10175	COG2116	formate transmembrane transporter activity
FORC53_RS10195	COG0583	DNA-binding transcription factor activity
FORC53_RS10200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC53_RS10210	COG1435	thymidine kinase activity
FORC53_RS10220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC53_RS10225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC53_RS10230	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC53_RS10240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC53_RS10240	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC53_RS10245	COG0107	imidazoleglycerol-phosphate synthase activity
FORC53_RS10250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC53_RS10255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC53_RS10260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC53_RS10260	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC53_RS10265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC53_RS10275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC53_RS10280	COG1757	Na H antiporter
FORC53_RS10285	COG2916	Histone family protein nucleoid-structuring protein H-NS
FORC53_RS10290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC53_RS10300	COG0482	sulfurtransferase activity
FORC53_RS10305	COG2915	High frequency lysogenization protein hflD homolog
FORC53_RS10310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC53_RS10330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC53_RS10345	COG1028	Short-chain dehydrogenase reductase Sdr
FORC53_RS10355	COG0501	Belongs to the peptidase M48B family
FORC53_RS10360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC53_RS10375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC53_RS10390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC53_RS10395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC53_RS10410	COG0686	Belongs to the AlaDH PNT family
FORC53_RS10420	COG0583	DNA-binding transcription factor activity
FORC53_RS10450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC53_RS10455	COG3108	Peptidase M15
FORC53_RS10460	COG2989	Protein conserved in bacteria
FORC53_RS10500	COG4608	Belongs to the ABC transporter superfamily
FORC53_RS10505	COG0444	Belongs to the ABC transporter superfamily
FORC53_RS10510	COG4166	transmembrane transport
FORC53_RS10515	COG4239	(ABC) transporter, permease
FORC53_RS10520	COG4174	ABC transporter (Permease)
FORC53_RS10530	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC53_RS10535	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC53_RS10545	COG0539	negative regulation of cytoplasmic translation
FORC53_RS10555	COG0616	signal peptide processing
FORC53_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
FORC53_RS10575	COG0587	DNA-directed DNA polymerase activity
FORC53_RS10580	COG0784	Response regulator, receiver
FORC53_RS10580	COG0835	chemotaxis
FORC53_RS10585	COG1940	carbohydrate kinase activity
FORC53_RS10590	COG0469	pyruvate kinase activity
FORC53_RS10595	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC53_RS10610	COG0733	neurotransmitter:sodium symporter activity
FORC53_RS10625	COG1263	PTS System
FORC53_RS10625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC53_RS10630	COG0084	hydrolase, TatD family'
FORC53_RS10640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC53_RS10645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC53_RS10660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC53_RS10675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC53_RS10680	COG0416	fatty acid biosynthetic process
FORC53_RS10685	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FORC53_RS10690	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC53_RS10705	COG1530	ribonuclease E activity
FORC53_RS10710	COG0659	secondary active sulfate transmembrane transporter activity
FORC53_RS10715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC53_RS10720	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC53_RS10730	COG0572	uridine kinase
FORC53_RS10740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC53_RS10740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC53_RS10750	COG3088	subunit of a heme lyase
FORC53_RS10750	COG4235	cytochrome complex assembly
FORC53_RS10755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC53_RS10760	COG1138	Cytochrome C-type biogenesis protein
FORC53_RS10765	COG3301	Polysulphide reductase, NrfD
FORC53_RS10770	COG0437	4 iron, 4 sulfur cluster binding
FORC53_RS10775	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC53_RS10780	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC53_RS10805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC53_RS10810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC53_RS10815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC53_RS10885	COG2197	response regulator
FORC53_RS10890	COG0417	DNA replication proofreading
FORC53_RS10895	COG5001	Diguanylate cyclase
FORC53_RS10905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC53_RS10925	COG0009	L-threonylcarbamoyladenylate synthase
FORC53_RS10930	COG0613	PHP domain protein
FORC53_RS10940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC53_RS10945	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC53_RS10955	COG0134	indole-3-glycerol-phosphate synthase activity
FORC53_RS10955	COG0135	phosphoribosylanthranilate isomerase activity
FORC53_RS10960	COG0133	tryptophan synthase activity
FORC53_RS10970	COG1301	dicarboxylic acid transport
FORC53_RS10990	COG2350	Protein conserved in bacteria
FORC53_RS11000	COG0435	Glutathione S-transferase
FORC53_RS11010	COG0444	Belongs to the ABC transporter superfamily
FORC53_RS11015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC53_RS11020	COG0601	transmembrane transport
FORC53_RS11030	COG0314	molybdopterin synthase activity
FORC53_RS11035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC53_RS11045	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC53_RS11055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC53_RS11060	COG2198	Histidine kinase
FORC53_RS11065	COG2204	response regulator
FORC53_RS11070	COG0556	nucleotide-excision repair
FORC53_RS11080	COG4657	Part of a membrane complex involved in electron transport
FORC53_RS11085	COG2878	Part of a membrane complex involved in electron transport
FORC53_RS11090	COG4656	Part of a membrane complex involved in electron transport
FORC53_RS11095	COG4658	electron transport chain
FORC53_RS11100	COG4659	FMN binding
FORC53_RS11105	COG4660	Part of a membrane complex involved in electron transport
FORC53_RS11110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC53_RS11115	COG0346	lactoylglutathione lyase activity
FORC53_RS11125	COG2885	chlorophyll binding
FORC53_RS11130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC53_RS11135	COG2056	Na+-H+ antiporter family
FORC53_RS11145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC53_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
FORC53_RS11165	COG1454	alcohol dehydrogenase
FORC53_RS11165	COG1012	belongs to the aldehyde dehydrogenase family
FORC53_RS11170	COG2095	MarC family integral membrane protein
FORC53_RS11175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC53_RS11185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC53_RS11190	COG1757	Na H antiporter
FORC53_RS11205	COG3081	Nucleoid-associated protein
FORC53_RS11215	COG3083	sulfuric ester hydrolase activity
FORC53_RS11225	COG0569	domain protein
FORC53_RS11230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC53_RS11235	COG2731	YhcH YjgK YiaL family protein
FORC53_RS11240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC53_RS11255	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC53_RS11260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC53_RS11265	COG0778	Nitroreductase
FORC53_RS11270	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC53_RS11270	COG1902	pentaerythritol trinitrate reductase activity
FORC53_RS11275	COG0616	signal peptide processing
FORC53_RS11280	COG0252	asparaginase activity
FORC53_RS11285	COG3139	Protein of unknown function (DUF1315)
FORC53_RS11300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC53_RS11335	COG5001	Diguanylate cyclase
FORC53_RS11350	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC53_RS11355	COG1946	Acyl-CoA thioesterase
FORC53_RS11365	COG1522	sequence-specific DNA binding
FORC53_RS11370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC53_RS11385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC53_RS11390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC53_RS11440	COG0318	PFAM AMP-dependent synthetase and ligase
FORC53_RS11450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC53_RS11465	COG1169	isochorismate synthase
FORC53_RS11470	COG0436	Aminotransferase
FORC53_RS11475	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC53_RS11480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC53_RS11495	COG1555	photosystem II stabilization
FORC53_RS11500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC53_RS11505	COG0776	regulation of translation
FORC53_RS11510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC53_RS11515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC53_RS11530	COG4191	Histidine kinase
FORC53_RS11535	COG2204	response regulator
FORC53_RS11545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC53_RS11550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC53_RS11555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC53_RS11560	COG3842	ATPase activity
FORC53_RS11570	COG1175	transmembrane transport
FORC53_RS11635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC53_RS11640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC53_RS11650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FORC53_RS11660	COG1216	Glycosyl transferase, family 2
FORC53_RS11665	COG2986	histidine ammonia-lyase
FORC53_RS11700	COG1028	Short-chain dehydrogenase reductase Sdr
FORC53_RS11715	COG5002	protein histidine kinase activity
FORC53_RS11720	COG0745	RESPONSE REGULATOR receiver
FORC53_RS11730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC53_RS11740	COG2951	lytic endotransglycosylase activity
FORC53_RS11750	COG0850	regulation of cytokinetic process
FORC53_RS11755	COG2894	cell division
FORC53_RS11760	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC53_RS11765	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC53_RS11770	COG0318	PFAM AMP-dependent synthetase and ligase
FORC53_RS11775	COG0596	Alpha beta hydrolase
FORC53_RS11790	COG1214	PFAM Peptidase M22, glycoprotease
FORC53_RS11795	COG1199	ATP-dependent helicase activity
FORC53_RS11805	COG0788	formyltetrahydrofolate deformylase activity
FORC53_RS11810	COG3102	Protein conserved in bacteria
FORC53_RS11830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FORC53_RS11835	COG1918	ferrous iron import across plasma membrane
FORC53_RS11845	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC53_RS11850	COG1121	(ABC) transporter
FORC53_RS11855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC53_RS11870	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC53_RS11875	COG0567	Dehydrogenase, E1 component
FORC53_RS11885	COG1053	succinate dehydrogenase
FORC53_RS11890	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC53_RS11895	COG2009	succinate dehydrogenase
FORC53_RS11905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC53_RS11915	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC53_RS11925	COG0251	oxidation-reduction process
FORC53_RS11930	COG2964	Protein conserved in bacteria
FORC53_RS11935	COG0033	Phosphoglucomutase
FORC53_RS11940	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC53_RS11945	COG0596	Alpha beta hydrolase
FORC53_RS11955	COG0716	FMN binding
FORC53_RS11970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC53_RS11975	COG2190	(PTS) system
FORC53_RS11975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC53_RS11975	COG1263	PTS System
FORC53_RS11980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC53_RS11985	COG1940	carbohydrate kinase activity
FORC53_RS11985	COG1846	Transcriptional regulator
FORC53_RS11990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC53_RS11990	COG4651	solute:proton antiporter activity
FORC53_RS11995	COG0367	asparagine synthase
FORC53_RS12005	COG3104	oligopeptide transport
FORC53_RS12010	COG0840	transmembrane signaling receptor activity
FORC53_RS12015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC53_RS12025	COG0326	Molecular chaperone. Has ATPase activity
FORC53_RS12030	COG3710	Transcriptional regulator
FORC53_RS12050	COG0622	Phosphoesterase
FORC53_RS12075	COG1090	epimerase
FORC53_RS12080	COG0300	oxidoreductase activity
FORC53_RS12090	COG3118	belongs to the thioredoxin family
FORC53_RS12095	COG0330	HflC and HflK could
FORC53_RS12125	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC53_RS12130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC53_RS12135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC53_RS12140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC53_RS12145	COG2190	(PTS) system
FORC53_RS12150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC53_RS12155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC53_RS12160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC53_RS12165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC53_RS12175	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC53_RS12175	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC53_RS12180	COG1706	bacterial-type flagellum-dependent cell motility
FORC53_RS12185	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC53_RS12195	COG4787	bacterial-type flagellum-dependent cell motility
FORC53_RS12200	COG1749	Flagellar hook protein flgE
FORC53_RS12215	COG1815	bacterial-type flagellum-dependent cell motility
FORC53_RS12220	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC53_RS12225	COG0835	chemotaxis
FORC53_RS12225	COG0784	Response regulator, receiver
FORC53_RS12285	COG2217	Heavy metal translocating P-type atpase
FORC53_RS12285	COG2608	mercury ion transmembrane transporter activity
FORC53_RS12300	COG3735	TraB family
FORC53_RS12315	COG2840	Smr protein MutS2
FORC53_RS12320	COG1187	pseudouridine synthase activity
FORC53_RS12335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC53_RS12340	COG2912	Transglutaminase-like superfamily
FORC53_RS12350	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC53_RS12355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC53_RS12360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC53_RS12370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC53_RS12375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC53_RS12380	COG0193	aminoacyl-tRNA hydrolase activity
FORC53_RS12470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC53_RS12480	COG1702	phosphate starvation-inducible protein PhoH
FORC53_RS12485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC53_RS12490	COG4535	Mg2 and Co2 transporter CorC
FORC53_RS12495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC53_RS12500	COG2888	peptidyl-tyrosine sulfation
FORC53_RS12510	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC53_RS12515	COG1466	dna polymerase III delta subunit
FORC53_RS12520	COG0799	negative regulation of ribosome biogenesis
FORC53_RS12525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC53_RS12530	COG0768	penicillin binding
FORC53_RS12535	COG0772	Belongs to the SEDS family
FORC53_RS12540	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC53_RS12545	COG1686	Belongs to the peptidase S11 family
FORC53_RS12550	COG2921	Belongs to the UPF0250 family
FORC53_RS12555	COG0321	lipoyl(octanoyl) transferase activity
FORC53_RS12560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC53_RS12570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC53_RS12600	COG0366	Alpha amylase catalytic
FORC53_RS12605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC53_RS12605	COG1263	PTS System
FORC53_RS12615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC53_RS12620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC53_RS12625	COG2011	ABC-type metal ion transport system permease component
FORC53_RS12630	COG1464	Belongs to the NlpA lipoprotein family
FORC53_RS12635	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC53_RS12660	COG1611	Belongs to the LOG family
FORC53_RS12680	COG2363	Small membrane protein
FORC53_RS12690	COG0583	DNA-binding transcription factor activity
FORC53_RS12705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC53_RS12710	COG1722	exodeoxyribonuclease VII activity
FORC53_RS12715	COG0142	geranyltranstransferase activity
FORC53_RS12720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC53_RS12725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC53_RS12730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC53_RS12735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC53_RS12740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FORC53_RS12755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC53_RS12755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC53_RS12760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC53_RS12770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC53_RS12780	COG1073	alpha beta
FORC53_RS12785	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC53_RS12790	COG2252	PERMEase
FORC53_RS12795	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC53_RS12825	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC53_RS12840	COG0583	DNA-binding transcription factor activity
FORC53_RS12845	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FORC53_RS12850	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FORC53_RS12855	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC53_RS12875	COG4969	Belongs to the N-Me-Phe pilin family
FORC53_RS12885	COG0484	heat shock protein binding
FORC53_RS12890	COG0443	Heat shock 70 kDa protein
FORC53_RS12920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC53_RS12925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC53_RS12930	COG0497	DNA recombination
FORC53_RS12935	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC53_RS12940	COG2914	Belongs to the UPF0125 (RnfH) family
FORC53_RS12945	COG2867	negative regulation of translational initiation
FORC53_RS12950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC53_RS13000	COG0009	L-threonylcarbamoyladenylate synthase
FORC53_RS13020	COG0583	DNA-binding transcription factor activity
FORC53_RS13025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC53_RS13030	COG1115	amino acid carrier protein
FORC53_RS13035	COG1584	GPR1 FUN34 yaaH family protein
FORC53_RS13045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC53_RS13045	COG0519	Catalyzes the synthesis of GMP from XMP
FORC53_RS13050	COG0516	GMP reductase activity
FORC53_RS13050	COG0517	IMP dehydrogenase activity
FORC53_RS13055	COG1570	exodeoxyribonuclease VII activity
FORC53_RS13065	COG2199	diguanylate cyclase activity
FORC53_RS13065	COG2203	Gaf domain
FORC53_RS13080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC53_RS13085	COG2976	Protein conserved in bacteria
FORC53_RS13090	COG0124	histidyl-tRNA synthetase
FORC53_RS13095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC53_RS13105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC53_RS13110	COG0105	UTP biosynthetic process
FORC53_RS13115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC53_RS13120	COG2975	iron-sulfur cluster assembly
FORC53_RS13125	COG0633	Ferredoxin
FORC53_RS13140	COG0316	Belongs to the HesB IscA family
FORC53_RS13145	COG0822	iron-sulfur transferase activity
FORC53_RS13155	COG1959	2 iron, 2 sulfur cluster binding
FORC53_RS13160	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FORC53_RS13165	COG0483	inositol monophosphate 1-phosphatase activity
FORC53_RS13180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC53_RS13185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC53_RS13190	COG1862	Preprotein translocase
FORC53_RS13195	COG0343	queuine tRNA-ribosyltransferase activity
FORC53_RS13210	COG0517	IMP dehydrogenase activity
FORC53_RS13220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC53_RS13225	COG0583	DNA-binding transcription factor activity
FORC53_RS13230	COG0450	alkyl hydroperoxide reductase
FORC53_RS13265	COG0704	Plays a role in the regulation of phosphate uptake
FORC53_RS13270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC53_RS13275	COG0581	inorganic phosphate transmembrane transporter activity
FORC53_RS13280	COG0573	inorganic phosphate transmembrane transporter activity
FORC53_RS13285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC53_RS13290	COG0248	Ppx GppA phosphatase
FORC53_RS13300	COG5002	protein histidine kinase activity
FORC53_RS13305	COG0745	RESPONSE REGULATOR receiver
FORC53_RS13315	COG0826	peptidase U32
FORC53_RS13320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC53_RS13375	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC53_RS13380	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC53_RS13385	COG1605	Chorismate mutase
FORC53_RS13385	COG0077	Prephenate dehydratase
FORC53_RS13390	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC53_RS13395	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC53_RS13405	COG0488	(ABC) transporter
FORC53_RS13415	COG0739	heme binding
FORC53_RS13420	COG1605	Chorismate mutase
FORC53_RS13420	COG0287	Prephenate dehydrogenase
FORC53_RS13455	COG1966	Carbon starvation protein
FORC53_RS13460	COG3275	phosphorelay sensor kinase activity
FORC53_RS13470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC53_RS13475	COG1047	Peptidyl-prolyl cis-trans
FORC53_RS13480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC53_RS13485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC53_RS13490	COG0196	riboflavin kinase activity
FORC53_RS13495	COG0728	peptidoglycan biosynthetic process
FORC53_RS13500	COG0268	Binds directly to 16S ribosomal RNA
FORC53_RS13505	COG0640	Transcriptional regulator
FORC53_RS13510	COG0583	DNA-binding transcription factor activity
FORC53_RS13515	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC53_RS13535	COG0730	response to heat
FORC53_RS13545	COG0494	nUDIX hydrolase
FORC53_RS13550	COG3066	DNA modification
FORC53_RS13560	COG0667	Aldo Keto reductase
FORC53_RS13585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC53_RS13590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC53_RS13595	COG4974	Belongs to the 'phage' integrase family
FORC53_RS13610	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC53_RS13615	COG0513	Belongs to the DEAD box helicase family
FORC53_RS13625	COG1115	amino acid carrier protein
FORC53_RS13640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC53_RS13650	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC53_RS13655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC53_RS13660	COG0083	homoserine kinase activity
FORC53_RS13675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC53_RS13690	COG0745	RESPONSE REGULATOR receiver
FORC53_RS13700	COG0784	Response regulator, receiver
FORC53_RS13700	COG2198	Histidine kinase
FORC53_RS13700	COG5002	protein histidine kinase activity
FORC53_RS13705	COG2203	Gaf domain
FORC53_RS13705	COG5001	Diguanylate cyclase
FORC53_RS13705	COG4251	negative regulation of phosphorylation
FORC53_RS13705	COG3706	GGDEF domain
FORC53_RS13710	COG1242	4 iron, 4 sulfur cluster binding
FORC53_RS13715	COG0070	glutamate synthase
FORC53_RS13715	COG0067	glutamate synthase
FORC53_RS13715	COG0069	glutamate synthase activity
FORC53_RS13725	COG0070	glutamate synthase
FORC53_RS13725	COG0069	glutamate synthase activity
FORC53_RS13725	COG0067	glutamate synthase
FORC53_RS13730	COG0493	'glutamate synthase
FORC53_RS13740	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC53_RS13750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC53_RS13755	COG2860	membrane
FORC53_RS13760	COG0583	DNA-binding transcription factor activity
FORC53_RS13765	COG0730	response to heat
FORC53_RS13775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC53_RS13780	COG0505	Belongs to the CarA family
FORC53_RS13790	COG0494	nUDIX hydrolase
FORC53_RS13795	COG0653	protein targeting
FORC53_RS13805	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORC53_RS13810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC53_RS13815	COG0849	cell division
FORC53_RS13820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC53_RS13825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC53_RS13835	COG0772	Belongs to the SEDS family
FORC53_RS13840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC53_RS13850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC53_RS13860	COG0768	penicillin binding
FORC53_RS13865	COG3116	cell division
FORC53_RS13870	COG0275	rRNA processing
FORC53_RS13880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC53_RS13885	COG3107	peptidoglycan biosynthetic process
FORC53_RS13890	COG0792	nuclease activity
FORC53_RS13895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC53_RS13900	COG2823	Periplasmic or secreted lipoprotein
FORC53_RS13905	COG2969	positive regulation of protein catabolic process
FORC53_RS13910	COG0625	glutathione transferase activity
FORC53_RS13915	COG2857	Cytochrome c1
FORC53_RS13920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC53_RS13925	COG0723	plastoquinol--plastocyanin reductase activity
FORC53_RS13930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC53_RS13935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC53_RS13945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC53_RS13950	COG3105	Protein conserved in bacteria
FORC53_RS13955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC53_RS13960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC53_RS13975	COG3150	esterase
FORC53_RS13985	COG3151	Protein conserved in bacteria
FORC53_RS13990	COG0494	nUDIX hydrolase
FORC53_RS13995	COG1538	Outer membrane efflux protein
FORC53_RS14015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC53_RS14020	COG3025	triphosphatase activity
FORC53_RS14025	COG1392	Phosphate transport regulator
FORC53_RS14030	COG0306	phosphate transporter
FORC53_RS14035	COG4991	sh3 domain protein
FORC53_RS14040	COG3267	Type II secretory pathway component ExeA
FORC53_RS14040	COG3409	Peptidoglycan-binding domain 1 protein
FORC53_RS14045	COG0617	tRNA 3'-terminal CCA addition
FORC53_RS14050	COG1968	undecaprenyl-diphosphatase activity
FORC53_RS14055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC53_RS14060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC53_RS14070	COG0596	Alpha beta hydrolase
FORC53_RS14075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC53_RS14080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC53_RS14085	COG1610	YqeY-like protein
FORC53_RS14105	COG0582	viral genome integration into host DNA
FORC53_RS14150	COG3339	Conserved Protein
FORC53_RS14165	COG2003	Belongs to the UPF0758 family
FORC53_RS14210	COG1518	maintenance of DNA repeat elements
FORC53_RS14235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC53_RS14240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC53_RS14240	COG2213	PTS system mannitol-specific
FORC53_RS14250	COG3722	fumarate hydratase activity
FORC53_RS14255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC53_RS14260	COG1349	DNA-binding transcription factor activity
FORC53_RS14275	COG3706	GGDEF domain
FORC53_RS14280	COG0440	acetolactate synthase activity
FORC53_RS14285	COG0028	Belongs to the TPP enzyme family
FORC53_RS14290	COG1022	Amp-dependent synthetase and ligase
FORC53_RS14315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC53_RS14320	COG0473	3-isopropylmalate dehydrogenase activity
FORC53_RS14330	COG0066	3-isopropylmalate dehydratase activity
FORC53_RS14345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC53_RS14360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC53_RS14365	COG2967	ApaG domain
FORC53_RS14370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC53_RS14380	COG3610	response to peptide
FORC53_RS14385	COG2966	Psort location CytoplasmicMembrane, score
FORC53_RS14395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FORC53_RS14400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC53_RS14405	COG0142	geranyltranstransferase activity
FORC53_RS14410	COG0039	L-malate dehydrogenase activity
FORC53_RS14415	COG1438	arginine binding
FORC53_RS14420	COG2358	TRAP transporter, solute receptor (TAXI family
FORC53_RS14430	COG0589	response to stress
FORC53_RS14435	COG0204	Acyl-transferase
FORC53_RS14440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC53_RS14445	COG5007	Belongs to the BolA IbaG family
FORC53_RS14455	COG2854	intermembrane phospholipid transfer
FORC53_RS14460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC53_RS14465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC53_RS14470	COG1127	ABC transporter
FORC53_RS14480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC53_RS14480	COG0517	IMP dehydrogenase activity
FORC53_RS14485	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FORC53_RS14495	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC53_RS14500	COG1137	ATPase activity
FORC53_RS14510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC53_RS14515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC53_RS14520	COG1660	Displays ATPase and GTPase activities
FORC53_RS14525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC53_RS14530	COG2239	Acts as a magnesium transporter
FORC53_RS14535	COG0312	modulator of DNA gyrase
FORC53_RS14540	COG3028	Belongs to the UPF0307 family
FORC53_RS14545	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC53_RS14550	COG1178	ABC-type Fe3 transport system permease component
FORC53_RS14555	COG4143	(ABC) transporter
FORC53_RS14560	COG0163	prenyltransferase activity
FORC53_RS14565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC53_RS14570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC53_RS14575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC53_RS14585	COG2105	PFAM AIG2 family protein
FORC53_RS14590	COG2911	Protein conserved in bacteria
FORC53_RS14595	COG0729	surface antigen
FORC53_RS14610	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC53_RS14625	COG0577	efflux transmembrane transporter activity
FORC53_RS14625	COG1136	(ABC) transporter
FORC53_RS14645	COG0529	Catalyzes the synthesis of activated sulfate
FORC53_RS14650	COG3273	potassium ion transport
FORC53_RS14650	COG0471	metal ion transport
FORC53_RS14660	COG0175	sulfate reduction
FORC53_RS14665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC53_RS14665	COG1648	precorrin-2 dehydrogenase activity
FORC53_RS14670	COG0737	Belongs to the 5'-nucleotidase family
FORC53_RS14680	COG2153	protein acetylation
FORC53_RS14690	COG3061	Opacity-associated protein A
FORC53_RS14690	COG3266	domain, Protein
FORC53_RS14695	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC53_RS14705	COG0203	ribosomal protein L17
FORC53_RS14710	COG0202	RNA polymerase activity
FORC53_RS14715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FORC53_RS14720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC53_RS14725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC53_RS14730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FORC53_RS14735	COG0201	protein transport
FORC53_RS14740	COG0200	Binds to the 23S rRNA
FORC53_RS14745	COG1841	ribosomal large subunit assembly
FORC53_RS14750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FORC53_RS14755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FORC53_RS14760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC53_RS14765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC53_RS14770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC53_RS14775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC53_RS14780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC53_RS14785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC53_RS14790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC53_RS14795	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC53_RS14800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FORC53_RS14805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC53_RS14815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC53_RS14820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC53_RS14825	COG0089	rRNA binding
FORC53_RS14830	COG0088	Forms part of the polypeptide exit tunnel
FORC53_RS14835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC53_RS14850	COG3064	Membrane
FORC53_RS14855	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FORC53_RS14870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FORC53_RS14880	COG1482	cell wall glycoprotein biosynthetic process
FORC53_RS14895	COG0438	transferase activity, transferring glycosyl groups
FORC53_RS14910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FORC53_RS14920	COG0647	UMP catabolic process
FORC53_RS14970	COG1596	polysaccharide export
FORC53_RS15025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC53_RS15035	COG1560	Kdo2-lipid A biosynthetic process
FORC53_RS15040	COG0859	PFAM glycosyl transferase family 9
FORC53_RS15045	COG1519	Transferase
FORC53_RS15075	COG0318	PFAM AMP-dependent synthetase and ligase
FORC53_RS15090	COG1028	Short-chain dehydrogenase reductase Sdr
FORC53_RS15095	COG1083	cytidylyl-transferase
FORC53_RS15105	COG0673	inositol 2-dehydrogenase activity
FORC53_RS15120	COG2089	acid synthase
FORC53_RS15125	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FORC53_RS15130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC53_RS15145	COG3083	sulfuric ester hydrolase activity
FORC53_RS15150	COG3642	lipopolysaccharide core region biosynthetic process
FORC53_RS15155	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC53_RS15160	COG0859	PFAM glycosyl transferase family 9
FORC53_RS15165	COG0463	Glycosyl transferase, family 2
FORC53_RS15170	COG0859	PFAM glycosyl transferase family 9
FORC53_RS15175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC53_RS15195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FORC53_RS15200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC53_RS15205	COG2003	Belongs to the UPF0758 family
FORC53_RS15210	COG0840	transmembrane signaling receptor activity
FORC53_RS15215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC53_RS15220	COG1309	transcriptional regulator
FORC53_RS15225	COG1560	Kdo2-lipid A biosynthetic process
FORC53_RS15235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC53_RS15240	COG1561	YicC-like family, N-terminal region
FORC53_RS15265	COG4608	Belongs to the ABC transporter superfamily
FORC53_RS15270	COG0444	Belongs to the ABC transporter superfamily
FORC53_RS15275	COG0747	negative chemotaxis
FORC53_RS15280	COG4239	(ABC) transporter, permease
FORC53_RS15285	COG4174	ABC transporter (Permease)
FORC53_RS15290	COG4206	TonB-dependent receptor
FORC53_RS15300	COG0811	peptide transport
FORC53_RS15305	COG0811	peptide transport
FORC53_RS15310	COG0848	biopolymer transport protein
FORC53_RS15325	COG0194	GDP metabolic process
FORC53_RS15330	COG1758	RNA polymerase activity
FORC53_RS15335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC53_RS15340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC53_RS15345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC53_RS15350	COG2233	PERMEase
FORC53_RS15365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC53_RS15370	COG2183	response to ionizing radiation
FORC53_RS15380	COG0596	Alpha beta hydrolase
FORC53_RS15390	COG0316	Belongs to the HesB IscA family
FORC53_RS15390	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC53_RS15395	COG0494	nUDIX hydrolase
FORC53_RS15400	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC53_RS15410	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC53_RS15415	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC53_RS15420	COG3156	type II secretion system protein K
FORC53_RS15425	COG4795	General secretion pathway protein
FORC53_RS15430	COG2165	general secretion pathway protein
FORC53_RS15435	COG2165	general secretion pathway protein
FORC53_RS15440	COG2165	general secretion pathway protein
FORC53_RS15445	COG1459	type II secretion system
FORC53_RS15450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC53_RS15460	COG3031	protein transport across the cell outer membrane
FORC53_RS15465	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC53_RS15470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC53_RS15485	COG0456	acetyltransferase
FORC53_RS15490	COG1490	D-aminoacyl-tRNA deacylase activity
FORC53_RS15495	COG1295	ribonuclease BN
FORC53_RS15505	COG1660	Displays ATPase and GTPase activities
FORC53_RS15510	COG1217	gtp-binding protein TYPA
FORC53_RS15520	COG0174	glutamine synthetase
FORC53_RS15530	COG3852	Histidine kinase
FORC53_RS15540	COG5001	Diguanylate cyclase
FORC53_RS15540	COG3300	MHYT domain
FORC53_RS15575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC53_RS15575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC53_RS15585	COG0084	hydrolase, TatD family'
FORC53_RS15590	COG0805	protein transport
FORC53_RS15595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC53_RS15600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC53_RS15610	COG3165	ubiquinone biosynthetic process from chorismate
FORC53_RS15615	COG2226	methyltransferase
FORC53_RS15620	COG1322	Protein conserved in bacteria
FORC53_RS15635	COG3335	DDE superfamily endonuclease
FORC53_RS15735	COG3118	belongs to the thioredoxin family
FORC53_RS15745	COG0248	Ppx GppA phosphatase
FORC53_RS15750	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC53_RS15765	COG0514	ATP-dependent DNA helicase (RecQ)
FORC53_RS15770	COG2962	Rard protein
FORC53_RS15780	COG1280	lysine exporter protein (LysE YggA)
FORC53_RS15790	COG0210	DNA helicase
FORC53_RS15830	COG0006	proline dipeptidase activity
FORC53_RS15830	COG0006	proline dipeptidase activity
FORC53_RS15840	COG2022	thiamine diphosphate biosynthetic process
FORC53_RS15850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC53_RS15860	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC53_RS15865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC53_RS15870	COG2132	Multicopper oxidase
FORC53_RS15915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC53_RS15935	COG0009	L-threonylcarbamoyladenylate synthase
FORC53_RS15940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC53_RS15950	COG0551	DNA topoisomerase type I activity
FORC53_RS15955	COG2922	Belongs to the Smg family
FORC53_RS15960	COG0758	DNA mediated transformation
FORC53_RS15970	COG0242	peptide deformylase activity
FORC53_RS15985	COG0569	domain protein
FORC53_RS15990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC53_RS15995	COG1272	protein, Hemolysin III
FORC53_RS16000	COG4326	sporulation control protein
FORC53_RS16005	COG3084	Protein conserved in bacteria
FORC53_RS16015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC53_RS16020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC53_RS16025	COG0204	Acyl-transferase
FORC53_RS16035	COG0606	chelatase, subunit chli
FORC53_RS16045	COG3978	acetolactate synthase activity
FORC53_RS16050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC53_RS16065	COG0583	DNA-binding transcription factor activity
FORC53_RS16070	COG2814	Major facilitator Superfamily
FORC53_RS16080	COG0765	amino acid transport
FORC53_RS16085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC53_RS16090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC53_RS16095	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC53_RS16100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORC53_RS16105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC53_RS16110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC53_RS16115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FORC53_RS16125	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC53_RS16130	COG3312	ion transport
FORC53_RS16135	COG1475	DNA binding
FORC53_RS16140	COG1192	Involved in chromosome partitioning
FORC53_RS16145	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC53_RS16150	COG0445	tRNA wobble uridine modification
FORC53_RS16160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC53_RS16170	COG0706	membrane insertase activity
FORC53_RS16180	COG0594	ribonuclease P activity
FORC53_RS16185	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FORC53_RS16190	COG1126	abc transporter atp-binding protein
FORC53_RS16215	COG4608	Belongs to the ABC transporter superfamily
FORC53_RS16220	COG0444	Belongs to the ABC transporter superfamily
FORC53_RS16230	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FORC53_RS16230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC53_RS16250	COG0217	transcriptional regulatory protein
FORC53_RS16260	COG0583	DNA-binding transcription factor activity
FORC53_RS16270	COG1136	(ABC) transporter
FORC53_RS16275	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC53_RS16290	COG3275	phosphorelay sensor kinase activity
FORC53_RS16315	COG0786	glutamate:sodium symporter activity
FORC53_RS16320	COG3385	transposase activity
FORC53_RS16325	COG0786	glutamate:sodium symporter activity
FORC53_RS16335	COG0363	glucosamine-6-phosphate deaminase activity
FORC53_RS16350	COG0189	ligase activity
FORC53_RS16370	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FORC53_RS16375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC53_RS16380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC53_RS16405	COG1309	transcriptional regulator
FORC53_RS16425	COG3123	guanosine phosphorylase activity
FORC53_RS16430	COG1741	Belongs to the pirin family
FORC53_RS16445	COG3706	GGDEF domain
FORC53_RS16500	COG1982	Orn Lys Arg decarboxylase major
FORC53_RS16505	COG0531	amino acid
FORC53_RS16510	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC53_RS16540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC53_RS16545	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC53_RS16550	COG1162	GTPase activity
FORC53_RS16555	COG2847	Copper chaperone PCu(A)C
FORC53_RS16560	COG1999	signal sequence binding
FORC53_RS16585	COG2909	trisaccharide binding
FORC53_RS16590	COG0058	SHG alpha-glucan phosphorylase activity
FORC53_RS16595	COG1640	4-alpha-glucanotransferase
FORC53_RS16610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC53_RS16670	COG1012	belongs to the aldehyde dehydrogenase family
FORC53_RS16675	COG0625	glutathione transferase activity
FORC53_RS16680	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC53_RS16685	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC53_RS16690	COG0612	Peptidase, M16
FORC53_RS16700	COG0583	DNA-binding transcription factor activity
FORC53_RS16705	COG0583	DNA-binding transcription factor activity
FORC53_RS16715	COG0387	Pfam Sodium calcium exchanger
FORC53_RS16720	COG0586	Pfam SNARE associated Golgi protein
FORC53_RS16730	COG0642	Histidine kinase
FORC53_RS16740	COG2199	diguanylate cyclase activity
FORC53_RS16765	COG1609	Transcriptional regulator
FORC53_RS16780	COG0395	ABC-type sugar transport system, permease component
FORC53_RS16790	COG3842	ATPase activity
FORC53_RS16795	COG1609	Transcriptional regulator
FORC53_RS16805	COG0747	negative chemotaxis
FORC53_RS16815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC53_RS16820	COG0444	Belongs to the ABC transporter superfamily
FORC53_RS16825	COG4608	Belongs to the ABC transporter superfamily
FORC53_RS16835	COG1609	Transcriptional regulator
FORC53_RS16850	COG4580	involved in the transport of maltose and maltodextrins
FORC53_RS16865	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC53_RS16870	COG0534	Mate efflux family protein
FORC53_RS16880	COG1566	PFAM secretion protein HlyD family protein
FORC53_RS16920	COG0564	pseudouridine synthase activity
FORC53_RS16925	COG3706	GGDEF domain
FORC53_RS16945	COG1609	Transcriptional regulator
FORC53_RS16955	COG1129	ABC transporter
FORC53_RS16975	COG4580	involved in the transport of maltose and maltodextrins
FORC53_RS16990	COG2211	Major facilitator Superfamily
FORC53_RS17000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC53_RS17005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC53_RS17010	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC53_RS17020	COG3708	Transcriptional regulator
FORC53_RS17020	COG2207	Transcriptional regulator
FORC53_RS17070	COG1482	cell wall glycoprotein biosynthetic process
FORC53_RS17075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC53_RS17075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC53_RS17075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC53_RS17080	COG2207	Transcriptional regulator
FORC53_RS17090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC53_RS17095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC53_RS17105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC53_RS17115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC53_RS17135	COG3383	formate dehydrogenase (NAD+) activity
FORC53_RS17145	COG0583	DNA-binding transcription factor activity
FORC53_RS17150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC53_RS17155	COG0583	DNA-binding transcription factor activity
FORC53_RS17170	COG0768	penicillin binding
FORC53_RS17200	COG0583	DNA-binding transcription factor activity
FORC53_RS17215	COG0137	argininosuccinate synthase activity
FORC53_RS17225	COG1301	dicarboxylic acid transport
FORC53_RS17270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC53_RS17275	COG2175	clavaminate synthase activity
FORC53_RS17305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC53_RS17315	COG3706	GGDEF domain
FORC53_RS17330	COG2356	endonuclease I
FORC53_RS17345	COG1368	sulfuric ester hydrolase activity
FORC53_RS17350	COG2194	sulfuric ester hydrolase activity
FORC53_RS17355	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC53_RS17360	COG2205	protein histidine kinase activity
FORC53_RS17365	COG0745	RESPONSE REGULATOR receiver
FORC53_RS17380	COG4221	oxidoreductase activity
FORC53_RS17405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC53_RS17410	COG0076	glutamate decarboxylase activity
FORC53_RS17415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC53_RS17425	COG0561	phosphatase activity
FORC53_RS17440	COG0671	phosphoesterase, PA-phosphatase related
FORC53_RS17515	COG2814	Major facilitator Superfamily
FORC53_RS17530	COG0039	L-malate dehydrogenase activity
FORC53_RS17535	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC53_RS17540	COG4771	TonB-dependent receptor
FORC53_RS17560	COG0393	Putative heavy-metal-binding
FORC53_RS17575	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC53_RS17625	COG0346	lactoylglutathione lyase activity
FORC53_RS17635	COG2211	Major facilitator Superfamily
FORC53_RS17650	COG3240	lipase activity
FORC53_RS17735	COG0582	viral genome integration into host DNA
FORC53_RS17750	COG3040	lipid binding
FORC53_RS17785	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FORC53_RS17795	COG2197	response regulator
FORC53_RS17815	COG2205	protein histidine kinase activity
FORC53_RS17815	COG0784	Response regulator, receiver
FORC53_RS17820	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC53_RS17830	COG2274	protein secretion by the type I secretion system
FORC53_RS17840	COG1538	Outer membrane efflux protein
FORC53_RS17860	COG0668	transmembrane transport
FORC53_RS17885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC53_RS17890	COG4946	Tricorn protease homolog
FORC53_RS17890	COG0793	Belongs to the peptidase S41A family
FORC53_RS17905	COG1122	ATPase activity
FORC53_RS17910	COG4720	Psort location CytoplasmicMembrane, score
FORC53_RS17915	COG1566	PFAM secretion protein HlyD family protein
FORC53_RS17940	COG0813	purine-nucleoside phosphorylase activity
FORC53_RS17945	COG3272	Protein of unknown function (DUF1722)
FORC53_RS17950	COG0789	Transcriptional regulator
FORC53_RS17955	COG0415	Belongs to the DNA photolyase family
FORC53_RS17960	COG1376	ErfK ybiS ycfS ynhG family protein
FORC53_RS17960	COG1388	LysM domain
FORC53_RS17970	COG0513	Belongs to the DEAD box helicase family
FORC53_RS18015	COG0573	inorganic phosphate transmembrane transporter activity
FORC53_RS18020	COG0581	inorganic phosphate transmembrane transporter activity
FORC53_RS18025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC53_RS18030	COG2203	Gaf domain
FORC53_RS18030	COG5001	Diguanylate cyclase
FORC53_RS18030	COG3706	GGDEF domain
FORC53_RS18030	COG4251	negative regulation of phosphorylation
FORC53_RS18060	COG0714	Associated with various cellular activities
FORC53_RS18130	COG1596	polysaccharide export
FORC53_RS18140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC53_RS18145	COG3842	ATPase activity
FORC53_RS18160	COG1175	transmembrane transport
FORC53_RS18165	COG3833	ABC-type maltose transport systems, permease component
FORC53_RS18195	COG2354	Protein conserved in bacteria
FORC53_RS18210	COG0633	Ferredoxin
FORC53_RS18210	COG3217	Mosc domain protein beta barrel domain protein
FORC53_RS18210	COG0633	Ferredoxin
FORC53_RS18210	COG3217	Mosc domain protein beta barrel domain protein
FORC53_RS18215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC53_RS18260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC53_RS18265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC53_RS18275	COG0848	biopolymer transport protein
FORC53_RS18280	COG0811	peptide transport
FORC53_RS18285	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC53_RS18295	COG3721	Heme iron utilization protein
FORC53_RS18300	COG0748	coenzyme F420 binding
FORC53_RS18310	COG0835	chemotaxis
FORC53_RS18310	COG0784	Response regulator, receiver
FORC53_RS18315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC53_RS18320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FORC53_RS18355	COG0328	RNA-DNA hybrid ribonuclease activity
FORC53_RS18370	COG0589	response to stress
FORC53_RS18375	COG0366	Alpha amylase catalytic
FORC53_RS18385	COG0840	transmembrane signaling receptor activity
FORC53_RS18400	COG3314	Sporulation integral membrane protein YlbJ
FORC53_RS18420	COG0739	heme binding
FORC53_RS18430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FORC53_RS18440	COG2084	Dehydrogenase
FORC53_RS18465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC53_RS18485	COG0840	transmembrane signaling receptor activity
FORC53_RS18500	COG3706	GGDEF domain
FORC53_RS18505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC53_RS18505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC53_RS18510	COG1765	OsmC-like protein
FORC53_RS18535	COG1011	Hydrolase
FORC53_RS18550	COG0840	transmembrane signaling receptor activity
FORC53_RS18560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC53_RS18575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC53_RS18585	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC53_RS18595	COG3842	ATPase activity
FORC53_RS18615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC53_RS18620	COG0583	DNA-binding transcription factor activity
FORC53_RS18630	COG3104	oligopeptide transport
FORC53_RS18635	COG1760	l-serine dehydratase
FORC53_RS18655	COG1686	Belongs to the peptidase S11 family
FORC53_RS18680	COG1012	belongs to the aldehyde dehydrogenase family
FORC53_RS18685	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FORC53_RS18700	COG4175	Glycine betaine
FORC53_RS18705	COG3059	membrane
FORC53_RS18720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FORC53_RS18740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC53_RS18750	COG0247	lactate metabolic process
FORC53_RS18765	COG1619	proteins homologs of microcin C7 resistance protein MccF
FORC53_RS18770	COG2133	pyrroloquinoline quinone binding
FORC53_RS18780	COG1454	alcohol dehydrogenase
FORC53_RS18785	COG0443	Heat shock 70 kDa protein
FORC53_RS18790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC53_RS18820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC53_RS18825	COG3174	membrane
FORC53_RS18850	COG0814	amino acid
FORC53_RS18855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC53_RS18880	COG2962	Rard protein
FORC53_RS18895	COG0671	phosphoesterase, PA-phosphatase related
FORC53_RS18905	COG1288	antiporter activity
FORC53_RS18920	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC53_RS18935	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FORC53_RS18940	COG2315	Protein conserved in bacteria
FORC53_RS18955	COG1869	D-ribose catabolic process
FORC53_RS18965	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC53_RS18970	COG1879	ABC-type sugar transport system periplasmic component
FORC53_RS18975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC53_RS18980	COG1609	Transcriptional regulator
FORC53_RS18990	COG0835	chemotaxis
FORC53_RS18990	COG0784	Response regulator, receiver
FORC53_RS19000	COG0456	acetyltransferase
FORC53_RS19015	COG1366	Belongs to the anti-sigma-factor antagonist family
FORC53_RS19025	COG2172	sigma factor antagonist activity
FORC53_RS19040	COG3437	response regulator, receiver
FORC53_RS19045	COG0420	3'-5' exonuclease activity
FORC53_RS19050	COG0419	ATPase involved in DNA repair
FORC53_RS19060	COG0583	DNA-binding transcription factor activity
FORC53_RS19080	COG4964	Belongs to the GSP D family
FORC53_RS19165	COG0471	metal ion transport
FORC53_RS19170	COG3290	protein histidine kinase activity
FORC53_RS19180	COG0110	maltose O-acetyltransferase activity
FORC53_RS19200	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC53_RS19205	COG4605	iron ion homeostasis
FORC53_RS19210	COG4604	ABC transporter, ATP-binding protein
FORC53_RS19215	COG0789	Transcriptional regulator
FORC53_RS19245	COG1289	transmembrane transporter activity
FORC53_RS19250	COG0210	DNA helicase
FORC53_RS19255	COG1803	Methylglyoxal synthase
FORC53_RS19260	COG1879	ABC-type sugar transport system periplasmic component
FORC53_RS19265	COG0784	Response regulator, receiver
FORC53_RS19265	COG2198	Histidine kinase
FORC53_RS19265	COG2205	protein histidine kinase activity
FORC53_RS19285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FORC53_RS19295	COG3005	denitrification pathway
FORC53_RS19320	COG0513	Belongs to the DEAD box helicase family
FORC53_RS19330	COG5001	Diguanylate cyclase
FORC53_RS19330	COG1716	ATPase activity
FORC53_RS19355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC53_RS19370	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FORC53_RS19375	COG0513	Belongs to the DEAD box helicase family
FORC53_RS19380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC53_RS19385	COG0457	Tetratricopeptide repeat
FORC53_RS19390	COG0477	Major facilitator Superfamily
FORC53_RS19390	COG2814	Major facilitator Superfamily
FORC53_RS19395	COG1940	carbohydrate kinase activity
FORC53_RS19410	COG3119	arylsulfatase activity
FORC53_RS19420	COG3119	arylsulfatase activity
FORC53_RS19425	COG0641	radical SAM
FORC53_RS19430	COG0714	Associated with various cellular activities
FORC53_RS19460	COG0583	DNA-binding transcription factor activity
FORC53_RS19465	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
FORC53_RS19475	COG0641	radical SAM
FORC53_RS19505	COG2814	Major facilitator Superfamily
FORC53_RS19560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC53_RS19570	COG1132	(ABC) transporter
FORC53_RS19595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC53_RS19595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC53_RS19600	COG0509	glycine decarboxylation via glycine cleavage system
FORC53_RS19605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC53_RS19650	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FORC53_RS19650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC53_RS19650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC53_RS19655	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC53_RS19660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC53_RS19660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC53_RS19665	COG1609	Transcriptional regulator
FORC53_RS19695	COG2271	Major facilitator Superfamily
FORC53_RS19705	COG4191	Histidine kinase
FORC53_RS19715	COG1979	alcohol dehydrogenase
FORC53_RS19720	COG2207	Transcriptional regulator
FORC53_RS19735	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FORC53_RS19740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC53_RS19755	COG3437	response regulator, receiver
FORC53_RS19755	COG0784	Response regulator, receiver
FORC53_RS19760	COG0546	phosphoglycolate phosphatase activity
FORC53_RS19780	COG0513	Belongs to the DEAD box helicase family
FORC53_RS19795	COG3038	cytochrome b561
FORC53_RS19800	COG2353	YceI-like domain
FORC53_RS19805	COG2116	formate transmembrane transporter activity
FORC53_RS19810	COG0583	DNA-binding transcription factor activity
FORC53_RS19820	COG3593	DNA synthesis involved in DNA repair
FORC53_RS19825	COG0737	Belongs to the 5'-nucleotidase family
FORC53_RS19830	COG0861	Integral membrane protein TerC family
FORC53_RS19860	COG2267	carboxylic ester hydrolase activity
FORC53_RS19865	COG2067	long-chain fatty acid transport protein
FORC53_RS19880	COG2050	protein possibly involved in aromatic compounds catabolism
FORC53_RS19890	COG4533	DNA binding
FORC53_RS19900	COG0366	Alpha amylase catalytic
FORC53_RS19905	COG0583	DNA-binding transcription factor activity
FORC53_RS19925	COG0484	heat shock protein binding
FORC53_RS19940	COG1716	ATPase activity
FORC53_RS19940	COG5001	Diguanylate cyclase
FORC53_RS19945	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC53_RS19955	COG4181	ATPase activity
FORC53_RS19960	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FORC53_RS19965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC53_RS19965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC53_RS19970	COG1984	allophanate hydrolase subunit 2
FORC53_RS19975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC53_RS19980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC53_RS19990	COG5002	protein histidine kinase activity
FORC53_RS19990	COG5001	Diguanylate cyclase
FORC53_RS19990	COG3447	MASE1 domain protein
FORC53_RS20000	COG0583	DNA-binding transcription factor activity
FORC53_RS20005	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC53_RS20005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC53_RS20005	COG1042	CoA-binding domain protein
FORC53_RS20025	COG0023	Translation Initiation Factor
FORC53_RS20110	COG1280	lysine exporter protein (LysE YggA)
FORC53_RS20140	COG3140	Belongs to the UPF0181 family
FORC53_RS20155	COG0745	RESPONSE REGULATOR receiver
FORC53_RS20165	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FORC53_RS20170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FORC53_RS20185	COG3706	GGDEF domain
FORC53_RS20195	COG2199	diguanylate cyclase activity
FORC53_RS20205	COG1846	Transcriptional regulator
FORC53_RS20210	COG0697	spore germination
FORC53_RS20220	COG4149	molybdate abc transporter
FORC53_RS20225	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC53_RS20245	COG0189	ligase activity
FORC53_RS20245	COG4067	protein conserved in archaea
FORC53_RS20255	COG0840	transmembrane signaling receptor activity
FORC53_RS20260	COG0602	queuosine metabolic process
FORC53_RS20265	COG1328	CTP reductase activity
FORC53_RS20320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC53_RS20325	COG3118	belongs to the thioredoxin family
FORC53_RS20330	COG0477	Major facilitator Superfamily
FORC53_RS20340	COG0534	Mate efflux family protein
FORC53_RS20355	COG0840	transmembrane signaling receptor activity
FORC53_RS20360	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC53_RS20375	COG0848	biopolymer transport protein
FORC53_RS20380	COG0811	peptide transport
FORC53_RS20385	COG0811	peptide transport
FORC53_RS20420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC53_RS20425	COG0840	transmembrane signaling receptor activity
FORC53_RS20455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC53_RS20465	COG5001	Diguanylate cyclase
FORC53_RS20465	COG4251	negative regulation of phosphorylation
FORC53_RS20465	COG3706	GGDEF domain
FORC53_RS20465	COG2203	Gaf domain
FORC53_RS20475	COG0010	Belongs to the arginase family
FORC53_RS20480	COG0513	Belongs to the DEAD box helicase family
FORC53_RS20490	COG0523	cobalamin synthesis protein
FORC53_RS20500	COG2199	diguanylate cyclase activity
FORC53_RS20515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC53_RS20515	COG2146	nitrite reductase [NAD(P)H] activity
FORC53_RS20520	COG1116	anion transmembrane transporter activity
FORC53_RS20525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC53_RS20530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC53_RS20530	COG1116	anion transmembrane transporter activity
FORC53_RS20535	COG3707	response regulator
FORC53_RS20550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC53_RS20550	COG1648	precorrin-2 dehydrogenase activity
FORC53_RS20555	COG0243	molybdopterin cofactor binding
FORC53_RS20560	COG0456	acetyltransferase
FORC53_RS20565	COG0366	Alpha amylase catalytic
FORC53_RS20590	COG2271	Major facilitator Superfamily
FORC53_RS20595	COG0584	glycerophosphoryl diester phosphodiesterase
FORC53_RS20600	COG0312	modulator of DNA gyrase
FORC53_RS20605	COG0312	modulator of DNA gyrase
FORC53_RS20615	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC53_RS20620	COG1704	LemA family
FORC53_RS20625	COG0501	Belongs to the peptidase M48B family
FORC53_RS20655	COG3335	DDE superfamily endonuclease
FORC53_RS20740	COG0631	protein serine/threonine phosphatase activity
FORC53_RS20775	COG2815	serine threonine protein kinase
FORC53_RS20775	COG0515	serine threonine protein kinase
FORC53_RS20795	COG3530	Putative quorum-sensing-regulated virulence factor
FORC53_RS20815	COG2154	pterin-4-alpha-carbinolamine dehydratase
FORC53_RS20820	COG3186	Phenylalanine-4-hydroxylase
FORC53_RS20825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC53_RS20850	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FORC53_RS20860	COG4191	Histidine kinase
FORC53_RS20860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC53_RS20865	COG0784	Response regulator, receiver
FORC53_RS20865	COG3437	response regulator, receiver
FORC53_RS20875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC53_RS20920	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FORC53_RS20920	COG1073	alpha beta
FORC53_RS20920	COG3064	Membrane
FORC53_RS20925	COG2994	toxin metabolic process
FORC53_RS20955	COG1028	Short-chain dehydrogenase reductase Sdr
FORC53_RS20965	COG1024	Enoyl-CoA hydratase
FORC53_RS20970	COG1024	Enoyl-CoA hydratase
FORC53_RS20975	COG1960	acyl-CoA dehydrogenase activity
FORC53_RS20985	COG0183	Belongs to the thiolase family
FORC53_RS20995	COG1960	acyl-CoA dehydrogenase activity
FORC53_RS21000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC53_RS21025	COG1278	Cold shock
FORC53_RS21040	COG1309	transcriptional regulator
FORC53_RS21045	COG2130	NADP-dependent
FORC53_RS21065	COG2197	response regulator
FORC53_RS21070	COG3851	Histidine kinase
FORC53_RS21075	COG2271	Major facilitator Superfamily
FORC53_RS21080	COG1482	cell wall glycoprotein biosynthetic process
FORC53_RS21090	COG2203	Gaf domain
FORC53_RS21090	COG2199	diguanylate cyclase activity
FORC53_RS21100	COG3036	rescue of stalled ribosome
FORC53_RS21105	COG1278	Cold shock
FORC53_RS21135	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC53_RS21140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC53_RS21145	COG0840	transmembrane signaling receptor activity
FORC53_RS21165	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC53_RS21175	COG4989	oxidoreductase activity
FORC53_RS21200	COG0038	chloride channel
FORC53_RS21210	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC53_RS21215	COG0302	gtp cyclohydrolase
FORC53_RS21220	COG0303	'Molybdopterin
FORC53_RS21225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC53_RS21235	COG2897	thiosulfate sulfurtransferase activity
FORC53_RS21260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC53_RS21275	COG0840	transmembrane signaling receptor activity
FORC53_RS21280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC53_RS21285	COG2885	chlorophyll binding
FORC53_RS21290	COG0109	protoheme IX farnesyltransferase activity
FORC53_RS21295	COG1612	heme a metabolic process
FORC53_RS21320	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FORC53_RS21325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORC53_RS21330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC53_RS21335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC53_RS21345	COG1280	lysine exporter protein (LysE YggA)
FORC53_RS21370	COG1846	Transcriptional regulator
FORC53_RS21375	COG1764	response to oxidative stress
FORC53_RS21385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC53_RS21400	COG0697	spore germination
FORC53_RS21415	COG2814	Major facilitator Superfamily
FORC53_RS21420	COG0583	DNA-binding transcription factor activity
FORC53_RS21425	COG2203	Gaf domain
FORC53_RS21425	COG4251	negative regulation of phosphorylation
FORC53_RS21425	COG3706	GGDEF domain
FORC53_RS21425	COG5001	Diguanylate cyclase
FORC53_RS21430	COG0251	oxidation-reduction process
FORC53_RS21445	COG4145	pantothenate transmembrane transporter activity
FORC53_RS21455	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FORC53_RS21465	COG0837	glucose binding
FORC53_RS21465	COG1737	Transcriptional regulator
FORC53_RS21475	COG1131	(ABC) transporter
FORC53_RS21480	COG0842	Transport permease protein
FORC53_RS21505	COG1846	Transcriptional regulator
FORC53_RS21520	COG0513	Belongs to the DEAD box helicase family
FORC53_RS21545	COG3568	Endonuclease Exonuclease Phosphatase
FORC53_RS21560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC53_RS21785	COG0741	lytic transglycosylase activity
FORC53_RS21815	COG0330	HflC and HflK could
FORC53_RS21835	COG3457	Alanine racemase
FORC53_RS21860	COG3604	Transcriptional regulator
FORC53_RS21870	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FORC53_RS21880	COG4208	sulfate ABC transporter
FORC53_RS21910	COG0628	permease
FORC53_RS21950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC53_RS22000	COG0516	GMP reductase activity
FORC53_RS22010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC53_RS22010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC53_RS22030	COG2197	response regulator
FORC53_RS22035	COG3850	Histidine kinase
FORC53_RS22040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC53_RS22060	COG3005	denitrification pathway
FORC53_RS22070	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
FORC53_RS22075	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
FORC53_RS22080	COG1737	Transcriptional regulator
FORC53_RS22085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC53_RS22090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC53_RS22095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC53_RS22100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC53_RS22105	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FORC53_RS22110	COG1940	carbohydrate kinase activity
FORC53_RS22115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC53_RS22135	COG0183	Belongs to the thiolase family
FORC53_RS22145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC53_RS22150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC53_RS22200	COG1879	ABC-type sugar transport system periplasmic component
FORC53_RS22210	COG2827	Endonuclease containing a URI domain
FORC53_RS22225	COG2926	Belongs to the UPF0265 family
FORC53_RS22230	COG0534	Mate efflux family protein
FORC53_RS22235	COG5002	protein histidine kinase activity
FORC53_RS22235	COG2205	protein histidine kinase activity
FORC53_RS22235	COG0784	Response regulator, receiver
FORC53_RS22260	COG0583	DNA-binding transcription factor activity
FORC53_RS22265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC53_RS22285	COG1522	sequence-specific DNA binding
FORC53_RS22295	COG0531	amino acid
FORC53_RS22300	COG0121	glutamine amidotransferase
FORC53_RS22315	COG2205	protein histidine kinase activity
FORC53_RS22320	COG0745	RESPONSE REGULATOR receiver
FORC53_RS22345	COG2239	Acts as a magnesium transporter
FORC53_RS22355	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FORC53_RS22360	COG0402	S-adenosylhomocysteine deaminase activity
FORC53_RS22365	COG1067	ATP-dependent peptidase activity
FORC53_RS22375	COG4172	Belongs to the ABC transporter superfamily
FORC53_RS22380	COG1505	serine-type exopeptidase activity
FORC53_RS22385	COG0583	DNA-binding transcription factor activity
FORC53_RS22390	COG1620	l-lactate permease
FORC53_RS22400	COG1139	Iron-sulfur cluster binding protein
FORC53_RS22430	COG2814	Major facilitator Superfamily
FORC53_RS22470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC53_RS22485	COG3015	lipoprotein NlpE involved in copper resistance
FORC53_RS22490	COG1126	abc transporter atp-binding protein
FORC53_RS22495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC53_RS22500	COG4215	(ABC) transporter
FORC53_RS22505	COG4160	amino acid transport
FORC53_RS22520	COG5001	Diguanylate cyclase
FORC53_RS22520	COG5002	protein histidine kinase activity
FORC53_RS22525	COG2755	lipolytic protein G-D-S-L family
FORC53_RS22535	COG0840	transmembrane signaling receptor activity
FORC53_RS22540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC53_RS22555	COG2977	Belongs to the P-Pant transferase superfamily
FORC53_RS22570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC53_RS22575	COG1028	Short-chain dehydrogenase reductase Sdr
FORC53_RS22580	COG1169	isochorismate synthase
FORC53_RS22585	COG1021	2,3-dihydroxybenzoate-AMP ligase
FORC53_RS22605	COG1021	2,3-dihydroxybenzoate-AMP ligase
FORC53_RS22615	COG4607	ABC-type enterochelin transport system periplasmic component
FORC53_RS22620	COG1629	transport
FORC53_RS22620	COG4774	siderophore transport
FORC53_RS22630	COG0189	ligase activity
FORC53_RS22635	COG0189	ligase activity
FORC53_RS22635	COG4067	protein conserved in archaea
FORC53_RS22660	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC53_RS22675	COG3033	Beta-eliminating lyase
FORC53_RS22680	COG0814	amino acid
FORC53_RS22685	COG0488	(ABC) transporter
FORC53_RS22700	COG1609	Transcriptional regulator
FORC53_RS22705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC53_RS22730	COG1253	flavin adenine dinucleotide binding
FORC53_RS22740	COG1012	belongs to the aldehyde dehydrogenase family
FORC53_RS22745	COG3284	Transcriptional regulator
FORC53_RS22755	COG1879	ABC-type sugar transport system periplasmic component
FORC53_RS22760	COG0625	glutathione transferase activity
FORC53_RS22770	COG0384	phenazine biosynthesis protein PhzF
FORC53_RS22775	COG2197	response regulator
FORC53_RS22810	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FORC53_RS22820	COG0583	DNA-binding transcription factor activity
FORC53_RS22825	COG2194	sulfuric ester hydrolase activity
FORC53_RS22845	COG0798	PFAM Bile acid sodium symporter
FORC53_RS22850	COG0640	Transcriptional regulator
FORC53_RS22865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC53_RS22870	COG0700	Nucleoside recognition
FORC53_RS22875	COG3366	ferrous iron transmembrane transporter activity
FORC53_RS22885	COG0366	Alpha amylase catalytic
FORC53_RS22895	COG0800	Aldolase
FORC53_RS22900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC53_RS22905	COG0697	spore germination
FORC53_RS22945	COG1917	Cupin 2, conserved barrel domain protein
FORC53_RS22955	COG1028	Short-chain dehydrogenase reductase Sdr
FORC53_RS22985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC53_RS22985	COG3153	acetyltransferase
FORC53_RS23005	COG0668	transmembrane transport
FORC53_RS23040	COG0494	nUDIX hydrolase
FORC53_RS23045	COG1881	PFAM PEBP family protein
FORC53_RS23050	COG2207	Transcriptional regulator
FORC53_RS23055	COG3046	protein related to deoxyribodipyrimidine photolyase
FORC53_RS23080	COG2205	protein histidine kinase activity
FORC53_RS23100	COG0454	-acetyltransferase
FORC53_RS23110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC53_RS23135	COG1858	cytochrome C peroxidase
FORC53_RS23155	COG2814	Major facilitator Superfamily
FORC53_RS23175	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC53_RS23185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC53_RS23195	COG0583	DNA-binding transcription factor activity
FORC53_RS23215	COG0513	Belongs to the DEAD box helicase family
FORC53_RS23250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC53_RS23260	COG1357	PFAM Pentapeptide repeats (8 copies)
FORC53_RS23280	COG3437	response regulator, receiver
FORC53_RS23290	COG0579	oxidoreductase
FORC53_RS23320	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FORC53_RS23335	COG2205	protein histidine kinase activity
FORC53_RS23370	COG3706	GGDEF domain
FORC53_RS23390	COG2176	DNA-directed DNA polymerase activity
FORC53_RS23395	COG0577	efflux transmembrane transporter activity
FORC53_RS23395	COG1136	(ABC) transporter
FORC53_RS23400	COG1136	(ABC) transporter
FORC53_RS23400	COG0577	efflux transmembrane transporter activity
FORC53_RS23435	COG1120	ATPase activity
FORC53_RS23440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC53_RS23470	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC53_RS23475	COG3716	PTS system mannose fructose sorbose family IID component
FORC53_RS23485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC53_RS23490	COG2222	sugar isomerase
FORC53_RS23500	COG1349	DNA-binding transcription factor activity
FORC53_RS23510	COG1349	DNA-binding transcription factor activity
FORC53_RS23515	COG0697	spore germination
FORC53_RS23520	COG2207	Transcriptional regulator
FORC53_RS23535	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FORC53_RS23560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC53_RS23565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC53_RS23585	COG0840	transmembrane signaling receptor activity
FORC53_RS23600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC53_RS23615	COG0583	DNA-binding transcription factor activity
FORC53_RS23620	COG1486	melibiose metabolic process
FORC53_RS23630	COG1522	sequence-specific DNA binding
FORC53_RS23645	COG2258	MOSC domain
FORC53_RS23670	COG1757	Na H antiporter
FORC53_RS23675	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FORC53_RS23680	COG0513	Belongs to the DEAD box helicase family
FORC53_RS23690	COG2186	Transcriptional regulator
FORC53_RS23700	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC53_RS23710	COG0246	Mannitol dehydrogenase
FORC53_RS23715	COG1904	glucuronate isomerase
FORC53_RS23720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC53_RS23725	COG0800	Aldolase
FORC53_RS23740	COG1028	Short-chain dehydrogenase reductase Sdr
FORC53_RS23745	COG2999	glutathione oxidoreductase activity
FORC53_RS23750	COG1902	pentaerythritol trinitrate reductase activity
FORC53_RS23785	COG0561	phosphatase activity
FORC53_RS23790	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FORC53_RS23795	COG3623	hexulose-6-phosphate isomerase
FORC53_RS23810	COG1132	(ABC) transporter
FORC53_RS23815	COG5492	domain, Protein
FORC53_RS23820	COG5426	von Willebrand factor, type A
FORC53_RS23830	COG1028	Short-chain dehydrogenase reductase Sdr
FORC53_RS23840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC53_RS23845	COG0659	secondary active sulfate transmembrane transporter activity
FORC53_RS23870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC53_RS23875	COG0601	transmembrane transport
FORC53_RS23880	COG0747	negative chemotaxis
FORC53_RS23890	COG3119	arylsulfatase activity
FORC53_RS23895	COG0641	radical SAM
FORC53_RS23900	COG3119	arylsulfatase activity
FORC53_RS23905	COG3119	arylsulfatase activity
FORC53_RS23910	COG5492	domain, Protein
FORC53_RS23930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC53_RS23955	COG0259	pyridoxamine-phosphate oxidase activity
FORC53_RS23965	COG2204	response regulator
FORC53_RS24000	COG0459	protein refolding
FORC53_RS24005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC53_RS24010	COG0110	maltose O-acetyltransferase activity
FORC53_RS24025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC53_RS24025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC53_RS24030	COG1737	Transcriptional regulator
FORC53_RS24040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC53_RS24045	COG1263	PTS System
FORC53_RS24045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC53_RS24055	COG2203	Gaf domain
FORC53_RS24055	COG2200	EAL domain
FORC53_RS24055	COG2199	diguanylate cyclase activity
FORC53_RS24060	COG0406	alpha-ribazole phosphatase activity
FORC53_RS24070	COG0583	DNA-binding transcription factor activity
FORC53_RS24075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC53_RS24110	COG0840	transmembrane signaling receptor activity
FORC53_RS24115	COG2201	protein-glutamate methylesterase activity
FORC53_RS24120	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FORC53_RS24125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC53_RS24130	COG0840	transmembrane signaling receptor activity
FORC53_RS24135	COG0835	chemotaxis
FORC53_RS24150	COG0745	RESPONSE REGULATOR receiver
FORC53_RS24160	COG1444	tRNA N-acetyltransferase activity
FORC53_RS24285	COG2916	Histone family protein nucleoid-structuring protein H-NS
FORC53_RS24335	COG1051	belongs to the nudix hydrolase family
FORC53_RS24345	COG0671	phosphoesterase, PA-phosphatase related
FORC53_RS24350	COG0671	phosphoesterase, PA-phosphatase related
FORC53_RS24385	COG0629	single-stranded DNA binding
FORC53_RS24565	COG0148	phosphopyruvate hydratase activity
FORC53_RS24750	COG4682	membrane
FORC53_RS24915	COG1129	ABC transporter
FORC53_RS25170	COG1328	CTP reductase activity
FORC53_RS25355	COG0671	phosphoesterase, PA-phosphatase related
FORC53_RS25420	COG0194	GDP metabolic process
FORC53_RS25590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC53_RS25695	COG1253	flavin adenine dinucleotide binding
FORC53_RS25745	COG0776	regulation of translation
FORC53_RS25750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC53_RS25755	COG1192	Involved in chromosome partitioning
FORC53_RS25785	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC53_RS25995	COG1160	GTP binding
FORC53_RS26040	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FORC53_RS26060	COG0628	permease
FORC53_RS26180	COG0629	single-stranded DNA binding
FORC53_RS26285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC53_RS26385	COG3341	Caulimovirus viroplasmin
FORC53_RS26385	COG0328	RNA-DNA hybrid ribonuclease activity
FORC53_RS26440	COG1546	Belongs to the CinA family
FORC53_RS26440	COG1058	Belongs to the CinA family
FORC53_RS26475	COG2137	regulation of response to DNA damage stimulus
FORC53_RS26515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC53_RS26525	COG1358	cellular component organization or biogenesis
FORC53_RS26640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC53_RS26645	COG2194	sulfuric ester hydrolase activity
FORC53_RS26655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC53_RS26715	COG0105	UTP biosynthetic process
FORC53_RS26860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC53_RS26860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC53_RS26900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC53_RS26960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC53_RS26990	COG0602	queuosine metabolic process
FORC53_RS26995	COG0776	regulation of translation
FORC53_RS27005	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC53_RS27090	COG2304	oxidoreductase activity
FORC53_RS27095	COG1570	exodeoxyribonuclease VII activity
FORC53_RS27110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORC53_RS27275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC53_RS27370	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC53_RS27390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC53_RS27400	COG0822	iron-sulfur transferase activity
FORC53_RS27420	COG1435	thymidine kinase activity
FORC53_RS27445	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FORC53_RS27465	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC53_RS27470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORC53_RS27510	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC53_RS27530	COG2353	YceI-like domain
FORC53_RS27535	COG3038	cytochrome b561
FORC53_RS27560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC53_RS27565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC53_RS27605	COG1358	cellular component organization or biogenesis
FORC53_RS27620	COG2310	stress, protein
FORC53_RS27635	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC53_RS27660	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC53_RS27675	COG3706	GGDEF domain
FORC53_RS27990	COG0210	DNA helicase
FORC53_RS28070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC53_RS28100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC53_RS28185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC53_RS28225	COG0740	serine-type endopeptidase activity
FORC53_RS28250	COG0653	protein targeting
FORC53_RS28260	COG1078	dGTPase activity
FORC53_RS28290	COG0497	DNA recombination
FORC53_RS28325	COG2974	May be involved in recombination
FORC53_RS28395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC53_RS28430	COG0514	ATP-dependent DNA helicase (RecQ)
FORC53_RS28440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC53_RS28450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC53_RS28470	COG0750	zinc metalloprotease
FORC53_RS28480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC53_RS28485	COG0305	Participates in initiation and elongation during chromosome replication
FORC53_RS28490	COG0587	DNA-directed DNA polymerase activity
FORC53_RS28505	COG0316	Belongs to the HesB IscA family
FORC53_RS28510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC53_RS28530	COG2200	EAL domain
FORC53_RS28545	COG0210	DNA helicase
FORC53_RS28555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC53_RS28595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC53_RS28595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC53_RS28600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC53_RS28615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC53_RS28660	COG2925	Exonuclease
FORC53_RS28720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC53_RS28735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC53_RS28835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC53_RS29015	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC53_RS29015	COG0678	peroxiredoxin activity
FORC53_RS29265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FORC53_RS29350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC53_RS29365	COG3550	peptidyl-serine autophosphorylation
FORC53_RS29490	COG2137	regulation of response to DNA damage stimulus
FORC53_RS29580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC53_RS29630	COG1199	ATP-dependent helicase activity
FORC53_RS29670	COG3093	addiction module antidote protein HigA
FORC53_RS29790	COG0494	nUDIX hydrolase