locus-tag	class	description
AOT11_RS00065	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AOT11_RS00070	COG0602	queuosine metabolic process
AOT11_RS00075	COG0561	phosphatase activity
AOT11_RS00105	COG2828	Protein conserved in bacteria
AOT11_RS00110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AOT11_RS00115	COG0372	Belongs to the citrate synthase family
AOT11_RS00120	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AOT11_RS00165	COG2197	response regulator
AOT11_RS00175	COG0730	response to heat
AOT11_RS00190	COG1653	transport
AOT11_RS00195	COG1175	transmembrane transport
AOT11_RS00200	COG0395	ABC-type sugar transport system, permease component
AOT11_RS00205	COG3842	ATPase activity
AOT11_RS00210	COG1349	DNA-binding transcription factor activity
AOT11_RS00215	COG0584	glycerophosphoryl diester phosphodiesterase
AOT11_RS00220	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AOT11_RS00230	COG1278	Cold shock
AOT11_RS00270	COG0625	glutathione transferase activity
AOT11_RS00280	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AOT11_RS00290	COG2195	Cleaves the N-terminal amino acid of tripeptides
AOT11_RS00295	COG0737	Belongs to the 5'-nucleotidase family
AOT11_RS00300	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AOT11_RS00305	COG3063	Type IV pilus biogenesis stability protein PilW
AOT11_RS00320	COG1451	nucleotide metabolic process
AOT11_RS00355	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AOT11_RS00385	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AOT11_RS00395	COG0702	epimerase
AOT11_RS00400	COG2925	Exonuclease
AOT11_RS00405	COG1380	Effector of murein hydrolase LrgA
AOT11_RS00410	COG1346	cytolysis
AOT11_RS00420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AOT11_RS00435	COG1643	Atp-dependent helicase
AOT11_RS00440	COG0281	malic enzyme
AOT11_RS00445	COG2949	membrane
AOT11_RS00450	COG0471	metal ion transport
AOT11_RS00470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AOT11_RS00480	COG0492	ferredoxin-NADP+ reductase activity
AOT11_RS00485	COG4988	ABC transporter
AOT11_RS00490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AOT11_RS00505	COG5002	protein histidine kinase activity
AOT11_RS00505	COG5002	protein histidine kinase activity
AOT11_RS00520	COG3070	regulator of competence-specific genes
AOT11_RS00530	COG2431	L-lysine efflux transmembrane transporter activity
AOT11_RS00540	COG0076	glutamate decarboxylase activity
AOT11_RS00545	COG1737	Transcriptional regulator
AOT11_RS00550	COG1979	alcohol dehydrogenase
AOT11_RS00555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AOT11_RS00565	COG3273	potassium ion transport
AOT11_RS00565	COG2985	domain, Protein
AOT11_RS00575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AOT11_RS00590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOT11_RS00605	COG1136	(ABC) transporter
AOT11_RS00610	COG0702	epimerase
AOT11_RS00620	COG2814	Major facilitator Superfamily
AOT11_RS00630	COG1061	Type III restriction enzyme res subunit
AOT11_RS00645	COG2205	protein histidine kinase activity
AOT11_RS00650	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AOT11_RS00680	COG3313	Fe-S protein
AOT11_RS00690	COG4134	Bacterial extracellular solute-binding protein
AOT11_RS00695	COG4135	transport system, permease component
AOT11_RS00700	COG4136	ATPase activity
AOT11_RS00705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AOT11_RS00710	COG3604	Transcriptional regulator
AOT11_RS00715	COG1151	hydroxylamine reductase activity
AOT11_RS00720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOT11_RS00725	COG0116	Belongs to the methyltransferase superfamily
AOT11_RS00725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOT11_RS00730	COG0564	pseudouridine synthase activity
AOT11_RS00740	COG0733	neurotransmitter:sodium symporter activity
AOT11_RS00750	COG0626	cystathionine gamma-synthase activity
AOT11_RS00755	COG2818	Glycosylase
AOT11_RS00775	COG1983	PspC domain protein
AOT11_RS00785	COG1842	Phage shock protein A
AOT11_RS00790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AOT11_RS00815	COG4172	Belongs to the ABC transporter superfamily
AOT11_RS00830	COG1227	inorganic diphosphatase activity
AOT11_RS00860	COG0243	molybdopterin cofactor binding
AOT11_RS00865	COG3005	denitrification pathway
AOT11_RS00870	COG4459	periplasmic nitrate reductase
AOT11_RS00875	COG0390	transport system, permease component
AOT11_RS00880	COG2116	formate transmembrane transporter activity
AOT11_RS00900	COG0583	DNA-binding transcription factor activity
AOT11_RS00905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOT11_RS00915	COG1435	thymidine kinase activity
AOT11_RS00925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AOT11_RS00930	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT11_RS00935	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AOT11_RS00940	COG3012	SEC-C Motif Domain Protein
AOT11_RS00955	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AOT11_RS00960	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AOT11_RS00965	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AOT11_RS00965	COG0131	Imidazoleglycerol-phosphate dehydratase
AOT11_RS00970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AOT11_RS00975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AOT11_RS00980	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AOT11_RS00985	COG1757	Na H antiporter
AOT11_RS00990	COG2916	Histone family protein nucleoid-structuring protein H-NS
AOT11_RS00995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT11_RS01005	COG0482	sulfurtransferase activity
AOT11_RS01010	COG2915	High frequency lysogenization protein hflD homolog
AOT11_RS01015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AOT11_RS01035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOT11_RS01050	COG1028	Short-chain dehydrogenase reductase Sdr
AOT11_RS01060	COG0501	Belongs to the peptidase M48B family
AOT11_RS01070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AOT11_RS01085	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AOT11_RS01100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AOT11_RS01105	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AOT11_RS01120	COG0686	Belongs to the AlaDH PNT family
AOT11_RS01130	COG0583	DNA-binding transcription factor activity
AOT11_RS01155	COG4608	Belongs to the ABC transporter superfamily
AOT11_RS01160	COG0444	Belongs to the ABC transporter superfamily
AOT11_RS01165	COG4166	transmembrane transport
AOT11_RS01170	COG4239	(ABC) transporter, permease
AOT11_RS01175	COG4174	ABC transporter (Permease)
AOT11_RS01180	COG0284	orotidine-5'-phosphate decarboxylase activity
AOT11_RS01185	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AOT11_RS01190	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AOT11_RS01200	COG0539	negative regulation of cytoplasmic translation
AOT11_RS01210	COG0616	signal peptide processing
AOT11_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
AOT11_RS01230	COG0587	DNA-directed DNA polymerase activity
AOT11_RS01235	COG0835	chemotaxis
AOT11_RS01235	COG0784	Response regulator, receiver
AOT11_RS01240	COG1940	carbohydrate kinase activity
AOT11_RS01245	COG0469	pyruvate kinase activity
AOT11_RS01250	COG4667	esterase of the alpha-beta hydrolase superfamily
AOT11_RS01260	COG0733	neurotransmitter:sodium symporter activity
AOT11_RS01275	COG1263	PTS System
AOT11_RS01275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AOT11_RS01280	COG0084	hydrolase, TatD family'
AOT11_RS01290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AOT11_RS01295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AOT11_RS01310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOT11_RS01325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AOT11_RS01330	COG0416	fatty acid biosynthetic process
AOT11_RS01335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AOT11_RS01340	COG1399	metal-binding, possibly nucleic acid-binding protein
AOT11_RS01345	COG0424	maF-like protein
AOT11_RS01355	COG1530	ribonuclease E activity
AOT11_RS01360	COG0659	secondary active sulfate transmembrane transporter activity
AOT11_RS01365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOT11_RS01370	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AOT11_RS01380	COG0572	uridine kinase
AOT11_RS01385	COG0489	protein tyrosine kinase activity
AOT11_RS01390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT11_RS01390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT11_RS01405	COG3088	subunit of a heme lyase
AOT11_RS01410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT11_RS01415	COG1138	Cytochrome C-type biogenesis protein
AOT11_RS01420	COG3301	Polysulphide reductase, NrfD
AOT11_RS01425	COG0437	4 iron, 4 sulfur cluster binding
AOT11_RS01430	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AOT11_RS01435	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AOT11_RS01460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOT11_RS01465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOT11_RS01470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOT11_RS01540	COG0322	excinuclease ABC activity
AOT11_RS01545	COG2197	response regulator
AOT11_RS01550	COG0417	DNA replication proofreading
AOT11_RS01555	COG5001	Diguanylate cyclase
AOT11_RS01565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOT11_RS01585	COG0009	L-threonylcarbamoyladenylate synthase
AOT11_RS01590	COG0613	PHP domain protein
AOT11_RS01600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AOT11_RS01605	COG0512	Glutamine amidotransferase of anthranilate synthase
AOT11_RS01610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AOT11_RS01615	COG0134	indole-3-glycerol-phosphate synthase activity
AOT11_RS01615	COG0135	phosphoribosylanthranilate isomerase activity
AOT11_RS01620	COG0133	tryptophan synthase activity
AOT11_RS01630	COG1301	dicarboxylic acid transport
AOT11_RS01650	COG2350	Protein conserved in bacteria
AOT11_RS01660	COG0435	Glutathione S-transferase
AOT11_RS01670	COG0444	Belongs to the ABC transporter superfamily
AOT11_RS01675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOT11_RS01680	COG0601	transmembrane transport
AOT11_RS01690	COG0314	molybdopterin synthase activity
AOT11_RS01695	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AOT11_RS01700	COG0315	cyclic pyranopterin monophosphate synthase activity
AOT11_RS01705	COG0521	Mo-molybdopterin cofactor biosynthetic process
AOT11_RS01715	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AOT11_RS01720	COG2198	Histidine kinase
AOT11_RS01725	COG2204	response regulator
AOT11_RS01730	COG0556	nucleotide-excision repair
AOT11_RS01745	COG4657	Part of a membrane complex involved in electron transport
AOT11_RS01750	COG2878	Part of a membrane complex involved in electron transport
AOT11_RS01755	COG4656	Part of a membrane complex involved in electron transport
AOT11_RS01760	COG4658	electron transport chain
AOT11_RS01765	COG4659	FMN binding
AOT11_RS01770	COG4660	Part of a membrane complex involved in electron transport
AOT11_RS01775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AOT11_RS01780	COG0346	lactoylglutathione lyase activity
AOT11_RS01790	COG2885	chlorophyll binding
AOT11_RS01795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOT11_RS01800	COG2056	Na+-H+ antiporter family
AOT11_RS01810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AOT11_RS01825	COG1028	Short-chain dehydrogenase reductase Sdr
AOT11_RS01835	COG1454	alcohol dehydrogenase
AOT11_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
AOT11_RS01840	COG2095	MarC family integral membrane protein
AOT11_RS01845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT11_RS01855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AOT11_RS01860	COG1757	Na H antiporter
AOT11_RS01875	COG3081	Nucleoid-associated protein
AOT11_RS01880	COG3082	Protein of unknown function (DUF1414)
AOT11_RS01885	COG3083	sulfuric ester hydrolase activity
AOT11_RS01895	COG0569	domain protein
AOT11_RS01900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOT11_RS01905	COG2731	YhcH YjgK YiaL family protein
AOT11_RS01920	COG2205	protein histidine kinase activity
AOT11_RS01920	COG0784	Response regulator, receiver
AOT11_RS01925	COG0123	including yeast histone deacetylase and acetoin utilization protein
AOT11_RS01930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AOT11_RS01935	COG0778	Nitroreductase
AOT11_RS01940	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOT11_RS01940	COG1902	pentaerythritol trinitrate reductase activity
AOT11_RS01945	COG0616	signal peptide processing
AOT11_RS01950	COG0252	asparaginase activity
AOT11_RS01955	COG3139	Protein of unknown function (DUF1315)
AOT11_RS01970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOT11_RS01975	COG0676	glucose-6-phosphate 1-epimerase activity
AOT11_RS02010	COG0330	HflC and HflK could
AOT11_RS02105	COG0732	type I restriction modification DNA specificity domain
AOT11_RS02175	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AOT11_RS02180	COG1946	Acyl-CoA thioesterase
AOT11_RS02190	COG1522	sequence-specific DNA binding
AOT11_RS02195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOT11_RS02210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT11_RS02275	COG0318	PFAM AMP-dependent synthetase and ligase
AOT11_RS02285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AOT11_RS02290	COG0596	Alpha beta hydrolase
AOT11_RS02300	COG1169	isochorismate synthase
AOT11_RS02305	COG0436	Aminotransferase
AOT11_RS02310	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AOT11_RS02315	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AOT11_RS02320	COG3148	PFAM DTW domain containing protein
AOT11_RS02330	COG1555	photosystem II stabilization
AOT11_RS02335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT11_RS02340	COG0776	regulation of translation
AOT11_RS02345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AOT11_RS02350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AOT11_RS02360	COG0544	peptidyl-prolyl cis-trans isomerase activity
AOT11_RS02365	COG4191	Histidine kinase
AOT11_RS02370	COG2204	response regulator
AOT11_RS02380	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AOT11_RS02385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AOT11_RS02390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AOT11_RS02400	COG3842	ATPase activity
AOT11_RS02410	COG1175	transmembrane transport
AOT11_RS02475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOT11_RS02480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOT11_RS02500	COG1216	Glycosyl transferase, family 2
AOT11_RS02505	COG2986	histidine ammonia-lyase
AOT11_RS02530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOT11_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
AOT11_RS02555	COG5002	protein histidine kinase activity
AOT11_RS02560	COG0745	RESPONSE REGULATOR receiver
AOT11_RS02570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AOT11_RS02580	COG2951	lytic endotransglycosylase activity
AOT11_RS02590	COG0850	regulation of cytokinetic process
AOT11_RS02595	COG2894	cell division
AOT11_RS02600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AOT11_RS02605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AOT11_RS02610	COG0318	PFAM AMP-dependent synthetase and ligase
AOT11_RS02615	COG0596	Alpha beta hydrolase
AOT11_RS02630	COG1214	PFAM Peptidase M22, glycoprotease
AOT11_RS02635	COG1199	ATP-dependent helicase activity
AOT11_RS02645	COG0788	formyltetrahydrofolate deformylase activity
AOT11_RS02650	COG3102	Protein conserved in bacteria
AOT11_RS02675	COG1918	ferrous iron import across plasma membrane
AOT11_RS02685	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AOT11_RS02690	COG1121	(ABC) transporter
AOT11_RS02695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOT11_RS02710	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOT11_RS02715	COG0567	Dehydrogenase, E1 component
AOT11_RS02725	COG1053	succinate dehydrogenase
AOT11_RS02730	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AOT11_RS02735	COG2009	succinate dehydrogenase
AOT11_RS02745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOT11_RS02755	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOT11_RS02765	COG0251	oxidation-reduction process
AOT11_RS02770	COG2964	Protein conserved in bacteria
AOT11_RS02775	COG0033	Phosphoglucomutase
AOT11_RS02780	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AOT11_RS02785	COG0596	Alpha beta hydrolase
AOT11_RS02795	COG0716	FMN binding
AOT11_RS02810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT11_RS02815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AOT11_RS02815	COG1263	PTS System
AOT11_RS02815	COG2190	(PTS) system
AOT11_RS02820	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AOT11_RS02825	COG1846	Transcriptional regulator
AOT11_RS02825	COG1940	carbohydrate kinase activity
AOT11_RS02830	COG4651	solute:proton antiporter activity
AOT11_RS02830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOT11_RS02835	COG0367	asparagine synthase
AOT11_RS02845	COG3104	oligopeptide transport
AOT11_RS02865	COG0326	Molecular chaperone. Has ATPase activity
AOT11_RS02870	COG3710	Transcriptional regulator
AOT11_RS02890	COG0622	Phosphoesterase
AOT11_RS02915	COG1090	epimerase
AOT11_RS02920	COG0300	oxidoreductase activity
AOT11_RS02925	COG3118	belongs to the thioredoxin family
AOT11_RS02930	COG0330	HflC and HflK could
AOT11_RS02960	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AOT11_RS02965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOT11_RS02970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT11_RS02975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOT11_RS02980	COG2190	(PTS) system
AOT11_RS02985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AOT11_RS02990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AOT11_RS03000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AOT11_RS03005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AOT11_RS03015	COG1705	Flagellar rod assembly protein muramidase FlgJ
AOT11_RS03015	COG3951	Flagellar rod assembly protein muramidase FlgJ
AOT11_RS03020	COG1706	bacterial-type flagellum-dependent cell motility
AOT11_RS03035	COG4787	bacterial-type flagellum-dependent cell motility
AOT11_RS03040	COG1749	Flagellar hook protein flgE
AOT11_RS03055	COG1815	bacterial-type flagellum-dependent cell motility
AOT11_RS03060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AOT11_RS03065	COG0784	Response regulator, receiver
AOT11_RS03065	COG0835	chemotaxis
AOT11_RS03125	COG2217	Heavy metal translocating P-type atpase
AOT11_RS03125	COG2608	mercury ion transmembrane transporter activity
AOT11_RS03140	COG3735	TraB family
AOT11_RS03160	COG2840	Smr protein MutS2
AOT11_RS03165	COG1187	pseudouridine synthase activity
AOT11_RS03180	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AOT11_RS03185	COG2912	Transglutaminase-like superfamily
AOT11_RS03195	COG2890	protein-(glutamine-N5) methyltransferase activity
AOT11_RS03200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AOT11_RS03210	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AOT11_RS03215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AOT11_RS03220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOT11_RS03225	COG0193	aminoacyl-tRNA hydrolase activity
AOT11_RS03315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT11_RS03320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOT11_RS03325	COG1702	phosphate starvation-inducible protein PhoH
AOT11_RS03330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AOT11_RS03335	COG4535	Mg2 and Co2 transporter CorC
AOT11_RS03345	COG2888	peptidyl-tyrosine sulfation
AOT11_RS03355	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AOT11_RS03360	COG1466	dna polymerase III delta subunit
AOT11_RS03365	COG0799	negative regulation of ribosome biogenesis
AOT11_RS03370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AOT11_RS03375	COG0768	penicillin binding
AOT11_RS03380	COG0772	Belongs to the SEDS family
AOT11_RS03385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AOT11_RS03390	COG1686	Belongs to the peptidase S11 family
AOT11_RS03395	COG2921	Belongs to the UPF0250 family
AOT11_RS03400	COG0321	lipoyl(octanoyl) transferase activity
AOT11_RS03405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOT11_RS03415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOT11_RS03445	COG0366	Alpha amylase catalytic
AOT11_RS03450	COG1263	PTS System
AOT11_RS03450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AOT11_RS03460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AOT11_RS03465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOT11_RS03470	COG2011	ABC-type metal ion transport system permease component
AOT11_RS03475	COG1464	Belongs to the NlpA lipoprotein family
AOT11_RS03480	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AOT11_RS03505	COG1611	Belongs to the LOG family
AOT11_RS03510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AOT11_RS03525	COG2363	Small membrane protein
AOT11_RS03535	COG0583	DNA-binding transcription factor activity
AOT11_RS03550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AOT11_RS03555	COG1722	exodeoxyribonuclease VII activity
AOT11_RS03560	COG0142	geranyltranstransferase activity
AOT11_RS03570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AOT11_RS03575	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AOT11_RS03580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AOT11_RS03585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AOT11_RS03600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOT11_RS03600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOT11_RS03605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AOT11_RS03615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AOT11_RS03625	COG1073	alpha beta
AOT11_RS03630	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AOT11_RS03635	COG2252	PERMEase
AOT11_RS03640	COG2195	Cleaves the N-terminal amino acid of tripeptides
AOT11_RS03680	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AOT11_RS03695	COG0583	DNA-binding transcription factor activity
AOT11_RS03700	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AOT11_RS03705	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AOT11_RS03710	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AOT11_RS03740	COG0484	heat shock protein binding
AOT11_RS03745	COG0443	Heat shock 70 kDa protein
AOT11_RS03780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AOT11_RS03785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AOT11_RS03790	COG0497	DNA recombination
AOT11_RS03795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT11_RS03800	COG2914	Belongs to the UPF0125 (RnfH) family
AOT11_RS03805	COG2867	negative regulation of translational initiation
AOT11_RS03810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AOT11_RS03860	COG0009	L-threonylcarbamoyladenylate synthase
AOT11_RS03880	COG0583	DNA-binding transcription factor activity
AOT11_RS03890	COG1115	amino acid carrier protein
AOT11_RS03895	COG1584	GPR1 FUN34 yaaH family protein
AOT11_RS03905	COG0519	Catalyzes the synthesis of GMP from XMP
AOT11_RS03905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOT11_RS03910	COG0517	IMP dehydrogenase activity
AOT11_RS03910	COG0516	GMP reductase activity
AOT11_RS03915	COG1570	exodeoxyribonuclease VII activity
AOT11_RS03925	COG2203	Gaf domain
AOT11_RS03925	COG2199	diguanylate cyclase activity
AOT11_RS03940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT11_RS03945	COG2976	Protein conserved in bacteria
AOT11_RS03950	COG0124	histidyl-tRNA synthetase
AOT11_RS03955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AOT11_RS03970	COG0105	UTP biosynthetic process
AOT11_RS03975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AOT11_RS03980	COG2975	iron-sulfur cluster assembly
AOT11_RS03985	COG0633	Ferredoxin
AOT11_RS03990	COG0443	Heat shock 70 kDa protein
AOT11_RS04000	COG0316	Belongs to the HesB IscA family
AOT11_RS04005	COG0822	iron-sulfur transferase activity
AOT11_RS04015	COG1959	2 iron, 2 sulfur cluster binding
AOT11_RS04020	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AOT11_RS04025	COG0483	inositol monophosphate 1-phosphatase activity
AOT11_RS04030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOT11_RS04035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOT11_RS04040	COG1862	Preprotein translocase
AOT11_RS04045	COG0343	queuine tRNA-ribosyltransferase activity
AOT11_RS04050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AOT11_RS04060	COG0517	IMP dehydrogenase activity
AOT11_RS04070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AOT11_RS04075	COG0583	DNA-binding transcription factor activity
AOT11_RS04080	COG0450	alkyl hydroperoxide reductase
AOT11_RS04095	COG0704	Plays a role in the regulation of phosphate uptake
AOT11_RS04100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AOT11_RS04105	COG0581	inorganic phosphate transmembrane transporter activity
AOT11_RS04110	COG0573	inorganic phosphate transmembrane transporter activity
AOT11_RS04115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AOT11_RS04120	COG0248	Ppx GppA phosphatase
AOT11_RS04130	COG5002	protein histidine kinase activity
AOT11_RS04135	COG0745	RESPONSE REGULATOR receiver
AOT11_RS04145	COG0826	peptidase U32
AOT11_RS04150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOT11_RS04190	COG0542	response to heat
AOT11_RS04205	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT11_RS04210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AOT11_RS04215	COG1605	Chorismate mutase
AOT11_RS04215	COG0077	Prephenate dehydratase
AOT11_RS04220	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AOT11_RS04225	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AOT11_RS04235	COG0488	(ABC) transporter
AOT11_RS04245	COG0739	heme binding
AOT11_RS04250	COG0287	Prephenate dehydrogenase
AOT11_RS04250	COG1605	Chorismate mutase
AOT11_RS04265	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AOT11_RS04285	COG1966	Carbon starvation protein
AOT11_RS04290	COG3275	phosphorelay sensor kinase activity
AOT11_RS04300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AOT11_RS04305	COG1047	Peptidyl-prolyl cis-trans
AOT11_RS04310	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AOT11_RS04315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AOT11_RS04320	COG0196	riboflavin kinase activity
AOT11_RS04325	COG0728	peptidoglycan biosynthetic process
AOT11_RS04330	COG0268	Binds directly to 16S ribosomal RNA
AOT11_RS04335	COG0640	Transcriptional regulator
AOT11_RS04340	COG0583	DNA-binding transcription factor activity
AOT11_RS04345	COG1283	sodium-dependent phosphate transmembrane transporter activity
AOT11_RS04355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AOT11_RS04425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AOT11_RS04460	COG0730	response to heat
AOT11_RS04470	COG0494	nUDIX hydrolase
AOT11_RS04475	COG3066	DNA modification
AOT11_RS04485	COG0667	Aldo Keto reductase
AOT11_RS04505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AOT11_RS04515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AOT11_RS04520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOT11_RS04525	COG4974	Belongs to the 'phage' integrase family
AOT11_RS04545	COG0513	Belongs to the DEAD box helicase family
AOT11_RS04550	COG3022	response to hydroperoxide
AOT11_RS04555	COG1115	amino acid carrier protein
AOT11_RS04570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AOT11_RS04580	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AOT11_RS04585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AOT11_RS04590	COG0083	homoserine kinase activity
AOT11_RS04605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOT11_RS04615	COG0745	RESPONSE REGULATOR receiver
AOT11_RS04625	COG0784	Response regulator, receiver
AOT11_RS04625	COG2198	Histidine kinase
AOT11_RS04625	COG5002	protein histidine kinase activity
AOT11_RS04630	COG3706	GGDEF domain
AOT11_RS04630	COG2203	Gaf domain
AOT11_RS04630	COG4251	negative regulation of phosphorylation
AOT11_RS04630	COG5001	Diguanylate cyclase
AOT11_RS04635	COG1242	4 iron, 4 sulfur cluster binding
AOT11_RS04640	COG0070	glutamate synthase
AOT11_RS04640	COG0069	glutamate synthase activity
AOT11_RS04640	COG0067	glutamate synthase
AOT11_RS04650	COG0070	glutamate synthase
AOT11_RS04650	COG0069	glutamate synthase activity
AOT11_RS04650	COG0067	glutamate synthase
AOT11_RS04655	COG0493	'glutamate synthase
AOT11_RS04665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AOT11_RS04675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AOT11_RS04680	COG2860	membrane
AOT11_RS04685	COG0583	DNA-binding transcription factor activity
AOT11_RS04690	COG0730	response to heat
AOT11_RS04705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AOT11_RS04710	COG0505	Belongs to the CarA family
AOT11_RS04720	COG0494	nUDIX hydrolase
AOT11_RS04725	COG0653	protein targeting
AOT11_RS04735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AOT11_RS04740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AOT11_RS04745	COG0849	cell division
AOT11_RS04750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AOT11_RS04755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOT11_RS04765	COG0772	Belongs to the SEDS family
AOT11_RS04775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AOT11_RS04780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AOT11_RS04790	COG0768	penicillin binding
AOT11_RS04795	COG3116	cell division
AOT11_RS04800	COG0275	rRNA processing
AOT11_RS04810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AOT11_RS04815	COG3107	peptidoglycan biosynthetic process
AOT11_RS04820	COG0792	nuclease activity
AOT11_RS04825	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AOT11_RS04830	COG2823	Periplasmic or secreted lipoprotein
AOT11_RS04835	COG2969	positive regulation of protein catabolic process
AOT11_RS04840	COG0625	glutathione transferase activity
AOT11_RS04845	COG2857	Cytochrome c1
AOT11_RS04850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AOT11_RS04855	COG0723	plastoquinol--plastocyanin reductase activity
AOT11_RS04860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOT11_RS04865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AOT11_RS04875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOT11_RS04880	COG3105	Protein conserved in bacteria
AOT11_RS04885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOT11_RS04890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOT11_RS04905	COG3150	esterase
AOT11_RS04915	COG3151	Protein conserved in bacteria
AOT11_RS04920	COG0494	nUDIX hydrolase
AOT11_RS04925	COG1538	Outer membrane efflux protein
AOT11_RS04935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AOT11_RS04945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOT11_RS04950	COG3025	triphosphatase activity
AOT11_RS04955	COG1392	Phosphate transport regulator
AOT11_RS04960	COG0306	phosphate transporter
AOT11_RS04965	COG4991	sh3 domain protein
AOT11_RS04970	COG3267	Type II secretory pathway component ExeA
AOT11_RS04970	COG3409	Peptidoglycan-binding domain 1 protein
AOT11_RS04975	COG0617	tRNA 3'-terminal CCA addition
AOT11_RS04980	COG1968	undecaprenyl-diphosphatase activity
AOT11_RS04985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AOT11_RS04990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AOT11_RS05000	COG0596	Alpha beta hydrolase
AOT11_RS05005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AOT11_RS05010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AOT11_RS05015	COG1610	YqeY-like protein
AOT11_RS05040	COG3550	peptidyl-serine autophosphorylation
AOT11_RS05055	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AOT11_RS05060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOT11_RS05065	COG1349	DNA-binding transcription factor activity
AOT11_RS05085	COG3706	GGDEF domain
AOT11_RS05090	COG0440	acetolactate synthase activity
AOT11_RS05095	COG0028	Belongs to the TPP enzyme family
AOT11_RS05100	COG1022	Amp-dependent synthetase and ligase
AOT11_RS05125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOT11_RS05130	COG0473	3-isopropylmalate dehydrogenase activity
AOT11_RS05140	COG0066	3-isopropylmalate dehydratase activity
AOT11_RS05165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AOT11_RS05170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOT11_RS05175	COG2967	ApaG domain
AOT11_RS05190	COG3610	response to peptide
AOT11_RS05195	COG2966	Psort location CytoplasmicMembrane, score
AOT11_RS05205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AOT11_RS05210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AOT11_RS05215	COG0142	geranyltranstransferase activity
AOT11_RS05220	COG0039	L-malate dehydrogenase activity
AOT11_RS05225	COG1438	arginine binding
AOT11_RS05230	COG2358	TRAP transporter, solute receptor (TAXI family
AOT11_RS05240	COG0589	response to stress
AOT11_RS05250	COG0204	Acyl-transferase
AOT11_RS05260	COG5007	Belongs to the BolA IbaG family
AOT11_RS05270	COG2854	intermembrane phospholipid transfer
AOT11_RS05275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOT11_RS05280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOT11_RS05285	COG1127	ABC transporter
AOT11_RS05295	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AOT11_RS05295	COG0517	IMP dehydrogenase activity
AOT11_RS05300	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AOT11_RS05310	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AOT11_RS05315	COG1137	ATPase activity
AOT11_RS05325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AOT11_RS05330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT11_RS05335	COG1660	Displays ATPase and GTPase activities
AOT11_RS05340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT11_RS05345	COG2239	Acts as a magnesium transporter
AOT11_RS05350	COG0312	modulator of DNA gyrase
AOT11_RS05355	COG3028	Belongs to the UPF0307 family
AOT11_RS05360	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AOT11_RS05365	COG1178	ABC-type Fe3 transport system permease component
AOT11_RS05370	COG4143	(ABC) transporter
AOT11_RS05375	COG0163	prenyltransferase activity
AOT11_RS05380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOT11_RS05385	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AOT11_RS05390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AOT11_RS05400	COG2105	PFAM AIG2 family protein
AOT11_RS05405	COG2911	Protein conserved in bacteria
AOT11_RS05410	COG0729	surface antigen
AOT11_RS05425	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AOT11_RS05440	COG0577	efflux transmembrane transporter activity
AOT11_RS05440	COG1136	(ABC) transporter
AOT11_RS05460	COG0529	Catalyzes the synthesis of activated sulfate
AOT11_RS05465	COG3273	potassium ion transport
AOT11_RS05465	COG0471	metal ion transport
AOT11_RS05470	COG2895	sulfate adenylyltransferase (ATP) activity
AOT11_RS05475	COG0175	sulfate reduction
AOT11_RS05480	COG1648	precorrin-2 dehydrogenase activity
AOT11_RS05480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AOT11_RS05485	COG0737	Belongs to the 5'-nucleotidase family
AOT11_RS05495	COG2153	protein acetylation
AOT11_RS05505	COG3266	domain, Protein
AOT11_RS05505	COG3061	Opacity-associated protein A
AOT11_RS05510	COG0545	Peptidyl-prolyl cis-trans isomerase
AOT11_RS05520	COG0203	ribosomal protein L17
AOT11_RS05525	COG0202	RNA polymerase activity
AOT11_RS05530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AOT11_RS05535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AOT11_RS05540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AOT11_RS05545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AOT11_RS05550	COG0201	protein transport
AOT11_RS05555	COG0200	Binds to the 23S rRNA
AOT11_RS05560	COG1841	ribosomal large subunit assembly
AOT11_RS05565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AOT11_RS05570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AOT11_RS05575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AOT11_RS05580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AOT11_RS05585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AOT11_RS05590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AOT11_RS05595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AOT11_RS05600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AOT11_RS05605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AOT11_RS05610	COG0255	Belongs to the universal ribosomal protein uL29 family
AOT11_RS05615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AOT11_RS05620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AOT11_RS05630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AOT11_RS05635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AOT11_RS05640	COG0089	rRNA binding
AOT11_RS05645	COG0088	Forms part of the polypeptide exit tunnel
AOT11_RS05650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AOT11_RS05715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AOT11_RS05720	COG5433	transposase activity
AOT11_RS05755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AOT11_RS05760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AOT11_RS05840	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT11_RS05860	COG1519	Transferase
AOT11_RS05880	COG2089	acid synthase
AOT11_RS05900	COG1083	cytidylyl-transferase
AOT11_RS05905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AOT11_RS05910	COG1086	Polysaccharide biosynthesis protein
AOT11_RS05935	COG3083	sulfuric ester hydrolase activity
AOT11_RS05940	COG3642	lipopolysaccharide core region biosynthetic process
AOT11_RS05945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AOT11_RS05950	COG0859	PFAM glycosyl transferase family 9
AOT11_RS05955	COG0463	Glycosyl transferase, family 2
AOT11_RS05960	COG0859	PFAM glycosyl transferase family 9
AOT11_RS05965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AOT11_RS05975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AOT11_RS05985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AOT11_RS05990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AOT11_RS05995	COG2003	Belongs to the UPF0758 family
AOT11_RS06000	COG0840	transmembrane signaling receptor activity
AOT11_RS06010	COG1309	transcriptional regulator
AOT11_RS06015	COG1560	Kdo2-lipid A biosynthetic process
AOT11_RS06025	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AOT11_RS06030	COG1561	YicC-like family, N-terminal region
AOT11_RS06045	COG0653	protein targeting
AOT11_RS06055	COG4608	Belongs to the ABC transporter superfamily
AOT11_RS06060	COG0444	Belongs to the ABC transporter superfamily
AOT11_RS06065	COG0747	negative chemotaxis
AOT11_RS06070	COG4239	(ABC) transporter, permease
AOT11_RS06075	COG4174	ABC transporter (Permease)
AOT11_RS06080	COG4206	TonB-dependent receptor
AOT11_RS06090	COG0811	peptide transport
AOT11_RS06095	COG0811	peptide transport
AOT11_RS06100	COG0848	biopolymer transport protein
AOT11_RS06115	COG0194	GDP metabolic process
AOT11_RS06120	COG1758	RNA polymerase activity
AOT11_RS06125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOT11_RS06130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT11_RS06135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AOT11_RS06140	COG2233	PERMEase
AOT11_RS06160	COG2183	response to ionizing radiation
AOT11_RS06170	COG0596	Alpha beta hydrolase
AOT11_RS06180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AOT11_RS06180	COG0316	Belongs to the HesB IscA family
AOT11_RS06185	COG0494	nUDIX hydrolase
AOT11_RS06190	COG1218	3'(2'),5'-bisphosphate nucleotidase
AOT11_RS06200	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AOT11_RS06205	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AOT11_RS06210	COG3156	type II secretion system protein K
AOT11_RS06215	COG4795	General secretion pathway protein
AOT11_RS06220	COG2165	general secretion pathway protein
AOT11_RS06225	COG2165	general secretion pathway protein
AOT11_RS06230	COG2165	general secretion pathway protein
AOT11_RS06235	COG1459	type II secretion system
AOT11_RS06240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AOT11_RS06250	COG3031	protein transport across the cell outer membrane
AOT11_RS06255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AOT11_RS06260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AOT11_RS06275	COG0456	acetyltransferase
AOT11_RS06280	COG1490	D-aminoacyl-tRNA deacylase activity
AOT11_RS06285	COG1295	ribonuclease BN
AOT11_RS06300	COG1217	gtp-binding protein TYPA
AOT11_RS06305	COG0174	glutamine synthetase
AOT11_RS06315	COG3852	Histidine kinase
AOT11_RS06320	COG2204	response regulator
AOT11_RS06325	COG3300	MHYT domain
AOT11_RS06325	COG5001	Diguanylate cyclase
AOT11_RS06355	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AOT11_RS06360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AOT11_RS06360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AOT11_RS06370	COG0084	hydrolase, TatD family'
AOT11_RS06375	COG0805	protein transport
AOT11_RS06380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOT11_RS06385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOT11_RS06395	COG3165	ubiquinone biosynthetic process from chorismate
AOT11_RS06400	COG2226	methyltransferase
AOT11_RS06405	COG1322	Protein conserved in bacteria
AOT11_RS06505	COG3118	belongs to the thioredoxin family
AOT11_RS06515	COG0248	Ppx GppA phosphatase
AOT11_RS06520	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AOT11_RS06530	COG0514	ATP-dependent DNA helicase (RecQ)
AOT11_RS06535	COG2962	Rard protein
AOT11_RS06545	COG1280	lysine exporter protein (LysE YggA)
AOT11_RS06550	COG0210	DNA helicase
AOT11_RS06590	COG0006	proline dipeptidase activity
AOT11_RS06590	COG0006	proline dipeptidase activity
AOT11_RS06600	COG2022	thiamine diphosphate biosynthetic process
AOT11_RS06610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AOT11_RS06615	COG0352	thiamine-phosphate diphosphorylase activity
AOT11_RS06620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AOT11_RS06625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AOT11_RS06630	COG2132	Multicopper oxidase
AOT11_RS06675	COG0582	viral genome integration into host DNA
AOT11_RS06725	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AOT11_RS06730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOT11_RS06735	COG1739	Uncharacterized protein family UPF0029
AOT11_RS06745	COG0183	Belongs to the thiolase family
AOT11_RS06750	COG0604	alcohol dehydrogenase
AOT11_RS06765	COG0425	Belongs to the sulfur carrier protein TusA family
AOT11_RS06775	COG2119	membrane
AOT11_RS06780	COG0752	glycyl-tRNA synthetase alpha subunit
AOT11_RS06785	COG0751	glycine-tRNA ligase activity
AOT11_RS06795	COG3977	Valine--pyruvate aminotransferase
AOT11_RS06805	COG0071	Belongs to the small heat shock protein (HSP20) family
AOT11_RS06810	COG0187	DNA topoisomerase II activity
AOT11_RS06820	COG0592	DNA-directed DNA polymerase activity
AOT11_RS06845	COG1126	abc transporter atp-binding protein
AOT11_RS06850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AOT11_RS06855	COG0594	ribonuclease P activity
AOT11_RS06865	COG0706	membrane insertase activity
AOT11_RS06875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AOT11_RS06885	COG0445	tRNA wobble uridine modification
AOT11_RS06890	COG0357	Ribosomal RNA small subunit methyltransferase G
AOT11_RS06895	COG1192	Involved in chromosome partitioning
AOT11_RS06900	COG1475	DNA binding
AOT11_RS06905	COG3312	ion transport
AOT11_RS06910	COG0356	it plays a direct role in the translocation of protons across the membrane
AOT11_RS06920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AOT11_RS06925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AOT11_RS06930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AOT11_RS06935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AOT11_RS06940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AOT11_RS06945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AOT11_RS06955	COG0765	amino acid transport
AOT11_RS06965	COG2814	Major facilitator Superfamily
AOT11_RS06970	COG0583	DNA-binding transcription factor activity
AOT11_RS06980	COG0129	dihydroxy-acid dehydratase activity
AOT11_RS06985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AOT11_RS06990	COG3978	acetolactate synthase activity
AOT11_RS07000	COG0606	chelatase, subunit chli
AOT11_RS07010	COG0204	Acyl-transferase
AOT11_RS07015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOT11_RS07020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AOT11_RS07030	COG3084	Protein conserved in bacteria
AOT11_RS07040	COG4326	sporulation control protein
AOT11_RS07045	COG1272	protein, Hemolysin III
AOT11_RS07050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOT11_RS07055	COG0569	domain protein
AOT11_RS07060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AOT11_RS07060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AOT11_RS07065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AOT11_RS07070	COG0242	peptide deformylase activity
AOT11_RS07080	COG0758	DNA mediated transformation
AOT11_RS07085	COG2922	Belongs to the Smg family
AOT11_RS07090	COG0551	DNA topoisomerase type I activity
AOT11_RS07105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AOT11_RS07110	COG0009	L-threonylcarbamoyladenylate synthase
AOT11_RS07115	COG0408	coproporphyrinogen oxidase activity
AOT11_RS07120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOT11_RS07130	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AOT11_RS07170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AOT11_RS07175	COG2960	long-chain fatty acid transporting porin activity
AOT11_RS07180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT11_RS07185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT11_RS07190	COG1309	transcriptional regulator
AOT11_RS07230	COG4172	Belongs to the ABC transporter superfamily
AOT11_RS07235	COG4166	transmembrane transport
AOT11_RS07240	COG0601	transmembrane transport
AOT11_RS07245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOT11_RS07280	COG0515	serine threonine protein kinase
AOT11_RS07280	COG2815	serine threonine protein kinase
AOT11_RS07290	COG0745	RESPONSE REGULATOR receiver
AOT11_RS07295	COG1609	Transcriptional regulator
AOT11_RS07300	COG0129	dihydroxy-acid dehydratase activity
AOT11_RS07305	COG3265	gluconokinase activity
AOT11_RS07310	COG2610	gluconate transmembrane transporter activity
AOT11_RS07315	COG0800	Aldolase
AOT11_RS07325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT11_RS07330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AOT11_RS07340	COG1522	sequence-specific DNA binding
AOT11_RS07345	COG5001	Diguanylate cyclase
AOT11_RS07345	COG5002	protein histidine kinase activity
AOT11_RS07350	COG0742	ribosomal rna small subunit methyltransferase
AOT11_RS07365	COG0589	response to stress
AOT11_RS07370	COG1528	Iron-storage protein
AOT11_RS07380	COG2081	HI0933 family
AOT11_RS07390	COG2959	enzyme of heme biosynthesis
AOT11_RS07400	COG0181	hydroxymethylbilane synthase activity
AOT11_RS07405	COG3072	Adenylate cyclase
AOT11_RS07410	COG1965	Belongs to the frataxin family
AOT11_RS07420	COG0019	diaminopimelate decarboxylase activity
AOT11_RS07425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AOT11_RS07435	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AOT11_RS07440	COG1011	Hydrolase
AOT11_RS07445	COG3287	FIST C domain
AOT11_RS07445	COG2200	EAL domain
AOT11_RS07445	COG2199	diguanylate cyclase activity
AOT11_RS07450	COG3148	PFAM DTW domain containing protein
AOT11_RS07465	COG0561	phosphatase activity
AOT11_RS07470	COG2267	carboxylic ester hydrolase activity
AOT11_RS07475	COG1280	lysine exporter protein (LysE YggA)
AOT11_RS07480	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AOT11_RS07485	COG0640	Transcriptional regulator
AOT11_RS07490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOT11_RS07535	COG2095	MarC family integral membrane protein
AOT11_RS07545	COG0742	ribosomal rna small subunit methyltransferase
AOT11_RS07550	COG0552	protein localization to endoplasmic reticulum
AOT11_RS07555	COG2884	Cell division ATP-binding protein ftsE
AOT11_RS07560	COG2177	Part of the ABC transporter FtsEX involved in
AOT11_RS07570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AOT11_RS07575	COG0705	Rhomboid family
AOT11_RS07580	COG1580	Controls the rotational direction of flagella during chemotaxis
AOT11_RS07585	COG3161	chorismate lyase activity
AOT11_RS07595	COG2937	Belongs to the GPAT DAPAT family
AOT11_RS07605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOT11_RS07615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT11_RS07635	COG4206	TonB-dependent receptor
AOT11_RS07720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT11_RS07730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AOT11_RS07735	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AOT11_RS07735	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AOT11_RS07765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AOT11_RS07770	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AOT11_RS07785	COG0081	regulation of translation
AOT11_RS07790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AOT11_RS07795	COG0222	ribosome binding
AOT11_RS07800	COG0085	RNA polymerase activity
AOT11_RS07805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AOT11_RS07810	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AOT11_RS07830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AOT11_RS07840	COG1573	uracil-dna glycosylase
AOT11_RS07850	COG3068	Protein conserved in bacteria
AOT11_RS07855	COG1253	flavin adenine dinucleotide binding
AOT11_RS07875	COG0138	bifunctional purine biosynthesis protein purh
AOT11_RS07885	COG0789	Transcriptional regulator
AOT11_RS07890	COG0840	transmembrane signaling receptor activity
AOT11_RS07895	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AOT11_RS07905	COG2264	protein methyltransferase activity
AOT11_RS07910	COG0439	Biotin carboxylase
AOT11_RS07915	COG0511	ligase activity, forming carbon-carbon bonds
AOT11_RS07920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AOT11_RS07925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOT11_RS07940	COG2814	Major facilitator Superfamily
AOT11_RS07945	COG2205	protein histidine kinase activity
AOT11_RS07945	COG2198	Histidine kinase
AOT11_RS07945	COG0784	Response regulator, receiver
AOT11_RS07960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOT11_RS07970	COG2095	MarC family integral membrane protein
AOT11_RS07980	COG4232	protein-disulfide reductase activity
AOT11_RS07985	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AOT11_RS07990	COG1027	Aspartate ammonia-lyase
AOT11_RS08000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AOT11_RS08005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOT11_RS08010	COG2205	protein histidine kinase activity
AOT11_RS08015	COG0745	RESPONSE REGULATOR receiver
AOT11_RS08020	COG3678	ATP-independent chaperone mediated protein folding
AOT11_RS08030	COG0205	6-phosphofructokinase activity
AOT11_RS08035	COG0534	Mate efflux family protein
AOT11_RS08040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AOT11_RS08045	COG0459	protein refolding
AOT11_RS08055	COG1285	pathogenesis
AOT11_RS08060	COG1509	lysine 2,3-aminomutase activity
AOT11_RS08065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOT11_RS08080	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AOT11_RS08085	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AOT11_RS08090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AOT11_RS08095	COG1053	succinate dehydrogenase
AOT11_RS08100	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AOT11_RS08120	COG4942	peptidase
AOT11_RS08125	COG1045	serine acetyltransferase
AOT11_RS08130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AOT11_RS08135	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AOT11_RS08140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AOT11_RS08150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AOT11_RS08160	COG0471	metal ion transport
AOT11_RS08165	COG0688	phosphatidylethanolamine metabolic process
AOT11_RS08170	COG1162	GTPase activity
AOT11_RS08175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AOT11_RS08220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AOT11_RS08225	COG0802	atpase or kinase
AOT11_RS08230	COG0860	N-Acetylmuramoyl-L-alanine amidase
AOT11_RS08235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AOT11_RS08245	COG1923	regulation of RNA biosynthetic process
AOT11_RS08250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AOT11_RS08255	COG0330	HflC and HflK could
AOT11_RS08260	COG0330	HflC and HflK could
AOT11_RS08265	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AOT11_RS08270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOT11_RS08275	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AOT11_RS08285	COG1959	2 iron, 2 sulfur cluster binding
AOT11_RS08290	COG0402	S-adenosylhomocysteine deaminase activity
AOT11_RS08295	COG0557	exoribonuclease II activity
AOT11_RS08300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT11_RS08305	COG0546	phosphoglycolate phosphatase activity
AOT11_RS08310	COG0180	Tryptophanyl-tRNA synthetase
AOT11_RS08330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOT11_RS08340	COG1012	belongs to the aldehyde dehydrogenase family
AOT11_RS08350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT11_RS08355	COG3954	Phosphoribulokinase
AOT11_RS08360	COG3089	Belongs to the UPF0270 family
AOT11_RS08365	COG0429	hydrolase of the alpha beta-hydrolase fold
AOT11_RS08375	COG0488	(ABC) transporter
AOT11_RS08380	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOT11_RS08395	COG1047	Peptidyl-prolyl cis-trans
AOT11_RS08405	COG2900	Belongs to the SlyX family
AOT11_RS08415	COG0545	Peptidyl-prolyl cis-trans isomerase
AOT11_RS08420	COG2964	Protein conserved in bacteria
AOT11_RS08425	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AOT11_RS08440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AOT11_RS08445	COG0049	tRNA binding
AOT11_RS08450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AOT11_RS08460	COG2906	2 iron, 2 sulfur cluster binding
AOT11_RS08470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOT11_RS08475	COG0149	triose-phosphate isomerase activity
AOT11_RS08500	COG1494	fructose-1,6-bisphosphatase
AOT11_RS08505	COG3074	FtsZ-dependent cytokinesis
AOT11_RS08515	COG1575	Belongs to the MenA family. Type 1 subfamily
AOT11_RS08520	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AOT11_RS08525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AOT11_RS08535	COG1609	Transcriptional regulator
AOT11_RS08540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AOT11_RS08550	COG0281	malic enzyme
AOT11_RS08555	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AOT11_RS08560	COG0626	cystathionine gamma-synthase activity
AOT11_RS08565	COG0527	aspartate kinase activity
AOT11_RS08565	COG0460	homoserine dehydrogenase
AOT11_RS08570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AOT11_RS08580	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AOT11_RS08585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOT11_RS08590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AOT11_RS08600	COG0137	argininosuccinate synthase activity
AOT11_RS08605	COG0165	Argininosuccinate lyase
AOT11_RS08605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AOT11_RS08620	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AOT11_RS08650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AOT11_RS08655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AOT11_RS08665	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AOT11_RS08670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOT11_RS08675	COG0360	Binds together with S18 to 16S ribosomal RNA
AOT11_RS08680	COG2965	DNA replication, synthesis of RNA primer
AOT11_RS08690	COG0359	binds to the 23S rRNA
AOT11_RS08705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AOT11_RS08715	COG0432	Pfam Uncharacterised protein family UPF0047
AOT11_RS08730	COG0735	belongs to the Fur family
AOT11_RS08760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT11_RS08855	COG0646	methionine synthase
AOT11_RS08855	COG1410	methionine synthase
AOT11_RS08860	COG0527	aspartate kinase activity
AOT11_RS08865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AOT11_RS08875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AOT11_RS08895	COG2199	diguanylate cyclase activity
AOT11_RS08895	COG2200	EAL domain
AOT11_RS08920	COG3267	Type II secretory pathway component ExeA
AOT11_RS08920	COG3409	Peptidoglycan-binding domain 1 protein
AOT11_RS08930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AOT11_RS08935	COG1459	type II secretion system
AOT11_RS08945	COG2165	general secretion pathway protein
AOT11_RS08950	COG2165	general secretion pathway protein
AOT11_RS08980	COG1077	Cell shape determining protein MreB Mrl
AOT11_RS08985	COG1792	Involved in formation and maintenance of cell shape
AOT11_RS08990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AOT11_RS08995	COG0424	maF-like protein
AOT11_RS09005	COG3164	Protein of unknown function
AOT11_RS09010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOT11_RS09015	COG0312	modulator of DNA gyrase
AOT11_RS09020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AOT11_RS09025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AOT11_RS09035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOT11_RS09040	COG0251	oxidation-reduction process
AOT11_RS09075	COG0456	acetyltransferase
AOT11_RS09085	COG4269	membrane
AOT11_RS09095	COG0525	valine-tRNA ligase activity
AOT11_RS09100	COG2927	DNA polymerase III (CHI subunit)
AOT11_RS09105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AOT11_RS09110	COG0795	lipopolysaccharide-transporting ATPase activity
AOT11_RS09115	COG0795	lipopolysaccharide-transporting ATPase activity
AOT11_RS09130	COG0726	polysaccharide deacetylase
AOT11_RS09135	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AOT11_RS09145	COG1447	Phosphotransferase system cellobiose-specific component IIA
AOT11_RS09150	COG1486	melibiose metabolic process
AOT11_RS09155	COG3394	polysaccharide catabolic process
AOT11_RS09160	COG1609	Transcriptional regulator
AOT11_RS09260	COG0840	transmembrane signaling receptor activity
AOT11_RS09280	COG0741	lytic transglycosylase activity
AOT11_RS09285	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AOT11_RS09295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AOT11_RS09300	COG2066	Belongs to the glutaminase family
AOT11_RS09305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOT11_RS09310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AOT11_RS09325	COG0762	integral membrane protein
AOT11_RS09330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AOT11_RS09335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AOT11_RS09350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AOT11_RS09355	COG1678	Uncharacterized ACR, COG1678
AOT11_RS09365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOT11_RS09375	COG2356	endonuclease I
AOT11_RS09390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AOT11_RS09395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AOT11_RS09405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOT11_RS09410	COG0126	phosphoglycerate kinase activity
AOT11_RS09415	COG0191	fructose-bisphosphate aldolase activity
AOT11_RS09420	COG0668	transmembrane transport
AOT11_RS09425	COG1279	arginine transmembrane transporter activity
AOT11_RS09440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOT11_RS09450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOT11_RS09460	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AOT11_RS09465	COG3079	Belongs to the UPF0149 family
AOT11_RS09470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT11_RS09475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT11_RS09490	COG0354	folic acid binding
AOT11_RS09505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AOT11_RS09510	COG1595	DNA-templated transcription, initiation
AOT11_RS09525	COG3086	response to oxidative stress
AOT11_RS09530	COG0481	GTPase activity
AOT11_RS09545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AOT11_RS09550	COG1381	Involved in DNA repair and RecF pathway recombination
AOT11_RS09555	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AOT11_RS09560	COG0736	holo-[acyl-carrier-protein] synthase activity
AOT11_RS09580	COG4999	Histidine kinase
AOT11_RS09580	COG3850	Histidine kinase
AOT11_RS09580	COG3437	response regulator, receiver
AOT11_RS09580	COG2205	protein histidine kinase activity
AOT11_RS09585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOT11_RS09590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOT11_RS09595	COG3956	TIGRFAM MazG family protein
AOT11_RS09600	COG0504	CTP synthase activity
AOT11_RS09615	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AOT11_RS09625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AOT11_RS09630	COG0585	pseudouridine synthase activity
AOT11_RS09640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AOT11_RS09645	COG4942	peptidase
AOT11_RS09645	COG1388	LysM domain
AOT11_RS09650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AOT11_RS09655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AOT11_RS09665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AOT11_RS09675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AOT11_RS09680	COG0527	aspartate kinase activity
AOT11_RS09685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AOT11_RS09730	COG3630	sodium ion export across plasma membrane
AOT11_RS09735	COG5016	pyruvate
AOT11_RS09735	COG0511	ligase activity, forming carbon-carbon bonds
AOT11_RS09740	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AOT11_RS09750	COG1238	metal cluster binding
AOT11_RS09755	COG0612	Peptidase, M16
AOT11_RS09770	COG1854	S-ribosylhomocysteine lyase activity
AOT11_RS09775	COG4536	flavin adenine dinucleotide binding
AOT11_RS09780	COG4137	Cytochrome C assembly protein
AOT11_RS09785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AOT11_RS09790	COG0228	four-way junction DNA binding
AOT11_RS09795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AOT11_RS09800	COG0336	Belongs to the RNA methyltransferase TrmD family
AOT11_RS09805	COG0335	large ribosomal subunit rRNA binding
AOT11_RS09810	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AOT11_RS09820	COG0237	dephospho-CoA kinase activity
AOT11_RS09830	COG1459	type II secretion system
AOT11_RS09835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AOT11_RS09850	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOT11_RS09855	COG2186	Transcriptional regulator
AOT11_RS09860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AOT11_RS09865	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOT11_RS09870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT11_RS09885	COG0288	reversible hydration of carbon dioxide
AOT11_RS09890	COG0659	secondary active sulfate transmembrane transporter activity
AOT11_RS09895	COG1131	(ABC) transporter
AOT11_RS09900	COG0842	Transport permease protein
AOT11_RS09910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AOT11_RS09915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AOT11_RS09925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT11_RS09930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AOT11_RS09935	COG1489	DNA binding
AOT11_RS09940	COG1643	Atp-dependent helicase
AOT11_RS09945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOT11_RS09950	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOT11_RS09955	COG1049	propionate catabolic process, 2-methylcitrate cycle
AOT11_RS09960	COG1929	Belongs to the glycerate kinase type-1 family
AOT11_RS09965	COG2610	gluconate transmembrane transporter activity
AOT11_RS09970	COG3835	regulator
AOT11_RS09975	COG3112	Uncharacterised protein family (UPF0231)
AOT11_RS09980	COG0347	Belongs to the P(II) protein family
AOT11_RS09985	COG0004	ammonium transporteR
AOT11_RS09990	COG1840	ABC-type Fe3 transport system, periplasmic component
AOT11_RS10000	COG3842	ATPase activity
AOT11_RS10005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT11_RS10020	COG2971	BadF BadG BcrA BcrD
AOT11_RS10030	COG4608	Belongs to the ABC transporter superfamily
AOT11_RS10035	COG0444	Belongs to the ABC transporter superfamily
AOT11_RS10040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOT11_RS10045	COG0601	transmembrane transport
AOT11_RS10050	COG0747	negative chemotaxis
AOT11_RS10055	COG2205	protein histidine kinase activity
AOT11_RS10055	COG0784	Response regulator, receiver
AOT11_RS10065	COG0628	permease
AOT11_RS10090	COG0739	heme binding
AOT11_RS10095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOT11_RS10105	COG2832	Protein of unknown function (DUF454)
AOT11_RS10110	COG2027	D-alanyl-D-alanine carboxypeptidase
AOT11_RS10125	COG1534	Rna-binding protein
AOT11_RS10130	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AOT11_RS10135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOT11_RS10140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOT11_RS10145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT11_RS10150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AOT11_RS10165	COG0779	Required for maturation of 30S ribosomal subunits
AOT11_RS10170	COG0195	Participates in both transcription termination and antitermination
AOT11_RS10180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AOT11_RS10185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AOT11_RS10190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AOT11_RS10210	COG1185	polyribonucleotide nucleotidyltransferase activity
AOT11_RS10225	COG0534	Mate efflux family protein
AOT11_RS10230	COG0826	peptidase U32
AOT11_RS10235	COG0826	peptidase U32
AOT11_RS10245	COG3154	lipid carrier protein
AOT11_RS10250	COG3153	acetyltransferase
AOT11_RS10260	COG0456	acetyltransferase
AOT11_RS10270	COG3706	GGDEF domain
AOT11_RS10280	COG0084	hydrolase, TatD family'
AOT11_RS10285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AOT11_RS10290	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AOT11_RS10295	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AOT11_RS10300	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AOT11_RS10305	COG0813	purine-nucleoside phosphorylase activity
AOT11_RS10315	COG0560	Phosphoserine phosphatase
AOT11_RS10325	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AOT11_RS10345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AOT11_RS10350	COG1022	Amp-dependent synthetase and ligase
AOT11_RS10385	COG4964	Belongs to the GSP D family
AOT11_RS10440	COG2059	Chromate
AOT11_RS10445	COG0583	DNA-binding transcription factor activity
AOT11_RS10455	COG3408	Glycogen debranching enzyme
AOT11_RS10455	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AOT11_RS10460	COG0531	amino acid
AOT11_RS10465	COG0531	amino acid
AOT11_RS10470	COG2731	YhcH YjgK YiaL family protein
AOT11_RS10475	COG3250	beta-galactosidase activity
AOT11_RS10485	COG1609	Transcriptional regulator
AOT11_RS10490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOT11_RS10500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AOT11_RS10505	COG2017	converts alpha-aldose to the beta-anomer
AOT11_RS10510	COG0840	transmembrane signaling receptor activity
AOT11_RS10520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT11_RS10535	COG0189	ligase activity
AOT11_RS10535	COG0569	domain protein
AOT11_RS10550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AOT11_RS10555	COG1349	DNA-binding transcription factor activity
AOT11_RS10560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOT11_RS10565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AOT11_RS10570	COG2171	N-acyltransferase activity
AOT11_RS10580	COG3141	response to X-ray
AOT11_RS10595	COG3083	sulfuric ester hydrolase activity
AOT11_RS10600	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AOT11_RS10605	COG1074	ATP-dependent DNA helicase activity
AOT11_RS10610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOT11_RS10630	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AOT11_RS10635	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AOT11_RS10640	COG2166	iron-sulfur cluster assembly
AOT11_RS10645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AOT11_RS10650	COG0693	protein deglycase activity
AOT11_RS10655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AOT11_RS10670	COG1595	DNA-templated transcription, initiation
AOT11_RS10680	COG2211	Major facilitator Superfamily
AOT11_RS10695	COG2813	Specifically methylates the guanine in position
AOT11_RS10700	COG0271	Belongs to the BolA IbaG family
AOT11_RS10705	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AOT11_RS10710	COG1805	sodium ion transport
AOT11_RS10715	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AOT11_RS10725	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AOT11_RS10730	COG2871	sodium ion transport
AOT11_RS10735	COG1477	protein flavinylation
AOT11_RS10750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOT11_RS10755	COG0514	ATP-dependent DNA helicase (RecQ)
AOT11_RS10770	COG0733	neurotransmitter:sodium symporter activity
AOT11_RS10795	COG1720	tRNA m6t6A37 methyltransferase activity
AOT11_RS10800	COG0254	rRNA binding
AOT11_RS10810	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AOT11_RS10815	COG1671	Belongs to the UPF0178 family
AOT11_RS10845	COG3098	single-species biofilm formation
AOT11_RS10860	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AOT11_RS10870	COG0024	Methionine aminopeptidase
AOT11_RS10875	COG0052	Belongs to the universal ribosomal protein uS2 family
AOT11_RS10880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AOT11_RS10885	COG0528	UMP kinase activity
AOT11_RS10890	COG0233	cytoplasmic translational termination
AOT11_RS10895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOT11_RS10900	COG0575	Belongs to the CDS family
AOT11_RS10910	COG0750	zinc metalloprotease
AOT11_RS10915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT11_RS10920	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AOT11_RS10925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT11_RS10930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AOT11_RS10935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT11_RS10940	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT11_RS10945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AOT11_RS10950	COG0587	DNA-directed DNA polymerase activity
AOT11_RS10955	COG0825	malonyl-CoA metabolic process
AOT11_RS10970	COG0347	Belongs to the P(II) protein family
AOT11_RS10975	COG3021	interspecies interaction between organisms
AOT11_RS10985	COG1388	LysM domain
AOT11_RS10985	COG0741	lytic transglycosylase activity
AOT11_RS10990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT11_RS10995	COG2226	methyltransferase
AOT11_RS11000	COG0328	RNA-DNA hybrid ribonuclease activity
AOT11_RS11015	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOT11_RS11035	COG1960	acyl-CoA dehydrogenase activity
AOT11_RS11045	COG0121	glutamine amidotransferase
AOT11_RS11050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOT11_RS11055	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AOT11_RS11060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AOT11_RS11065	COG2233	PERMEase
AOT11_RS11085	COG1393	Belongs to the ArsC family
AOT11_RS11090	COG4783	chaperone-mediated protein folding
AOT11_RS11105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AOT11_RS11110	COG2716	regulation of RNA biosynthetic process
AOT11_RS11115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOT11_RS11120	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AOT11_RS11140	COG1393	Belongs to the ArsC family
AOT11_RS11165	COG2837	iron assimilation
AOT11_RS11170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AOT11_RS11175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AOT11_RS11180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AOT11_RS11185	COG1334	flagellar protein FlaG
AOT11_RS11190	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AOT11_RS11200	COG1516	flagellar protein fliS
AOT11_RS11220	COG1677	Flagellar hook-basal body complex protein FliE
AOT11_RS11230	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AOT11_RS11280	COG1987	bacterial-type flagellum assembly
AOT11_RS11285	COG1684	flagellar biosynthetic protein fliR
AOT11_RS11320	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AOT11_RS11325	COG0643	Histidine kinase
AOT11_RS11325	COG0784	Response regulator, receiver
AOT11_RS11325	COG2198	Histidine kinase
AOT11_RS11335	COG1192	Involved in chromosome partitioning
AOT11_RS11345	COG0835	chemotaxis
AOT11_RS11355	COG4133	protoheme IX ABC transporter activity
AOT11_RS11360	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AOT11_RS11365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AOT11_RS11370	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AOT11_RS11375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AOT11_RS11380	COG1138	Cytochrome C-type biogenesis protein
AOT11_RS11385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT11_RS11390	COG3088	subunit of a heme lyase
AOT11_RS11390	COG4235	cytochrome complex assembly
AOT11_RS11400	COG2853	Lipoprotein
AOT11_RS11405	COG2067	long-chain fatty acid transport protein
AOT11_RS11410	COG2067	long-chain fatty acid transport protein
AOT11_RS11435	COG1025	Belongs to the peptidase M16 family
AOT11_RS11445	COG2062	phosphohistidine phosphatase, SixA
AOT11_RS11450	COG2840	Smr protein MutS2
AOT11_RS11455	COG2890	protein-(glutamine-N5) methyltransferase activity
AOT11_RS11465	COG2860	membrane
AOT11_RS11470	COG3101	peptidyl-lysine hydroxylation
AOT11_RS11485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOT11_RS11495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AOT11_RS11505	COG0101	tRNA pseudouridine synthase activity
AOT11_RS11510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AOT11_RS11515	COG0285	dihydrofolate synthase activity
AOT11_RS11520	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AOT11_RS11525	COG1286	toxin biosynthetic process
AOT11_RS11530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AOT11_RS11535	COG0583	DNA-binding transcription factor activity
AOT11_RS11540	COG0745	RESPONSE REGULATOR receiver
AOT11_RS11550	COG2832	Protein of unknown function (DUF454)
AOT11_RS11555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AOT11_RS11565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AOT11_RS11570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AOT11_RS11585	COG2205	protein histidine kinase activity
AOT11_RS11590	COG0745	RESPONSE REGULATOR receiver
AOT11_RS11595	COG0814	amino acid
AOT11_RS11600	COG0251	oxidation-reduction process
AOT11_RS11610	COG2964	Protein conserved in bacteria
AOT11_RS11620	COG2983	Belongs to the UPF0260 family
AOT11_RS11630	COG0346	lactoylglutathione lyase activity
AOT11_RS11640	COG1785	Belongs to the alkaline phosphatase family
AOT11_RS11655	COG2226	methyltransferase
AOT11_RS11660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AOT11_RS11715	COG1396	sequence-specific DNA binding
AOT11_RS11720	COG3550	peptidyl-serine autophosphorylation
AOT11_RS11725	COG0582	viral genome integration into host DNA
AOT11_RS11730	COG2239	Acts as a magnesium transporter
AOT11_RS11735	COG2203	Gaf domain
AOT11_RS11735	COG2199	diguanylate cyclase activity
AOT11_RS11755	COG3710	Transcriptional regulator
AOT11_RS11760	COG0531	amino acid
AOT11_RS11765	COG1982	Orn Lys Arg decarboxylase major
AOT11_RS11770	COG3706	GGDEF domain
AOT11_RS11775	COG0617	tRNA 3'-terminal CCA addition
AOT11_RS11775	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AOT11_RS11775	COG0517	IMP dehydrogenase activity
AOT11_RS11800	COG0537	adenosine 5'-monophosphoramidase activity
AOT11_RS11830	COG1252	NADH dehydrogenase
AOT11_RS11845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AOT11_RS11855	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOT11_RS11860	COG1136	(ABC) transporter
AOT11_RS11865	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOT11_RS11875	COG2333	competence protein COMEC
AOT11_RS11875	COG0658	competence protein
AOT11_RS11885	COG1663	tetraacyldisaccharide 4'-kinase activity
AOT11_RS11890	COG2835	tetraacyldisaccharide 4'-kinase activity
AOT11_RS11895	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AOT11_RS11900	COG2199	diguanylate cyclase activity
AOT11_RS11905	COG2719	SpoVR family
AOT11_RS11910	COG2718	Belongs to the UPF0229 family
AOT11_RS11915	COG2766	serine protein kinase
AOT11_RS11920	COG3013	Belongs to the UPF0304 family
AOT11_RS11930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AOT11_RS11945	COG1882	Formate acetyltransferase
AOT11_RS11985	COG0708	Exodeoxyribonuclease III
AOT11_RS11990	COG0840	transmembrane signaling receptor activity
AOT11_RS12000	COG3923	Primosomal replication protein n
AOT11_RS12010	COG1199	ATP-dependent helicase activity
AOT11_RS12015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AOT11_RS12035	COG1278	Cold shock
AOT11_RS12040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AOT11_RS12045	COG0542	response to heat
AOT11_RS12050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AOT11_RS12055	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AOT11_RS12070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AOT11_RS12080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AOT11_RS12090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AOT11_RS12115	COG3070	regulator of competence-specific genes
AOT11_RS12120	COG1609	Transcriptional regulator
AOT11_RS12130	COG0745	RESPONSE REGULATOR receiver
AOT11_RS12135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AOT11_RS12140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOT11_RS12145	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AOT11_RS12150	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AOT11_RS12155	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AOT11_RS12170	COG0189	ligase activity
AOT11_RS12170	COG4067	protein conserved in archaea
AOT11_RS12175	COG0500	methyltransferase
AOT11_RS12185	COG4106	trans-aconitate 2-methyltransferase activity
AOT11_RS12205	COG0632	four-way junction helicase activity
AOT11_RS12210	COG2255	four-way junction helicase activity
AOT11_RS12215	COG1271	oxidase subunit
AOT11_RS12220	COG1294	oxidase, subunit
AOT11_RS12225	COG4890	Cyd operon protein YbgT
AOT11_RS12235	COG0824	Thioesterase
AOT11_RS12240	COG0811	peptide transport
AOT11_RS12255	COG0823	Involved in the tonB-independent uptake of proteins
AOT11_RS12260	COG2885	chlorophyll binding
AOT11_RS12265	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AOT11_RS12270	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AOT11_RS12280	COG3766	membrane
AOT11_RS12290	COG0754	glutathionylspermidine amidase activity
AOT11_RS12300	COG2205	protein histidine kinase activity
AOT11_RS12300	COG0784	Response regulator, receiver
AOT11_RS12405	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AOT11_RS12420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOT11_RS12425	COG0840	transmembrane signaling receptor activity
AOT11_RS12430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOT11_RS12435	COG0861	Integral membrane protein TerC family
AOT11_RS12460	COG2207	Transcriptional regulator
AOT11_RS12480	COG1032	radical SAM domain protein
AOT11_RS12505	COG0583	DNA-binding transcription factor activity
AOT11_RS12515	COG0857	belongs to the CobB CobQ family
AOT11_RS12515	COG0280	phosphate acetyltransferase
AOT11_RS12520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AOT11_RS12525	COG3092	negative regulation of chromosome organization
AOT11_RS12535	COG4120	Belongs to the binding-protein-dependent transport system permease family
AOT11_RS12545	COG0366	Alpha amylase catalytic
AOT11_RS12560	COG0653	protein targeting
AOT11_RS12570	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOT11_RS12575	COG2186	Transcriptional regulator
AOT11_RS12605	COG2989	Protein conserved in bacteria
AOT11_RS12610	COG3108	Peptidase M15
AOT11_RS12615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT11_RS12630	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AOT11_RS12655	COG1846	Transcriptional regulator
AOT11_RS12660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOT11_RS12685	COG1448	Aminotransferase
AOT11_RS12690	COG2770	Histidine kinase
AOT11_RS12690	COG3437	response regulator, receiver
AOT11_RS12705	COG0017	Asparaginyl-tRNA synthetase
AOT11_RS12710	COG0840	transmembrane signaling receptor activity
AOT11_RS12715	COG0720	synthase
AOT11_RS12730	COG2200	EAL domain
AOT11_RS12735	COG1760	l-serine dehydratase
AOT11_RS12740	COG0814	amino acid
AOT11_RS12745	COG0494	nUDIX hydrolase
AOT11_RS12755	COG0784	Response regulator, receiver
AOT11_RS12755	COG2205	protein histidine kinase activity
AOT11_RS12760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AOT11_RS12775	COG3106	COG3106 Predicted ATPase
AOT11_RS12780	COG3768	UPF0283 membrane protein
AOT11_RS12785	COG3283	Transcriptional regulator of aromatic amino acids metabolism
AOT11_RS12790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOT11_RS12805	COG0471	metal ion transport
AOT11_RS12810	COG4191	Histidine kinase
AOT11_RS12810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT11_RS12820	COG3706	GGDEF domain
AOT11_RS12825	COG2199	diguanylate cyclase activity
AOT11_RS12825	COG2200	EAL domain
AOT11_RS12840	COG5001	Diguanylate cyclase
AOT11_RS12840	COG3300	MHYT domain
AOT11_RS12845	COG1328	CTP reductase activity
AOT11_RS12850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AOT11_RS12855	COG0583	DNA-binding transcription factor activity
AOT11_RS12870	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AOT11_RS12880	COG4667	esterase of the alpha-beta hydrolase superfamily
AOT11_RS12890	COG1597	lipid kinase activity
AOT11_RS12895	COG0814	amino acid
AOT11_RS12910	COG0783	Belongs to the Dps family
AOT11_RS12925	COG1132	(ABC) transporter
AOT11_RS12930	COG1132	(ABC) transporter
AOT11_RS12935	COG1115	amino acid carrier protein
AOT11_RS12940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOT11_RS12950	COG1596	polysaccharide export
AOT11_RS12980	COG0438	transferase activity, transferring glycosyl groups
AOT11_RS12980	COG0297	glycogen (starch) synthase activity
AOT11_RS12995	COG2165	general secretion pathway protein
AOT11_RS13035	COG0443	Heat shock 70 kDa protein
AOT11_RS13040	COG0443	Heat shock 70 kDa protein
AOT11_RS13050	COG3706	GGDEF domain
AOT11_RS13070	COG3713	MltA-interacting MipA family protein
AOT11_RS13100	COG4964	Belongs to the GSP D family
AOT11_RS13110	COG2894	cell division
AOT11_RS13150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AOT11_RS13160	COG1643	Atp-dependent helicase
AOT11_RS13185	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AOT11_RS13190	COG5380	lipid catabolic process
AOT11_RS13195	COG2814	Major facilitator Superfamily
AOT11_RS13200	COG0010	Belongs to the arginase family
AOT11_RS13205	COG1166	arginine decarboxylase activity
AOT11_RS13270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AOT11_RS13295	COG0776	regulation of translation
AOT11_RS13305	COG0500	methyltransferase
AOT11_RS13310	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AOT11_RS13315	COG0295	cytidine deaminase activity
AOT11_RS13330	COG2885	chlorophyll binding
AOT11_RS13345	COG0247	lactate metabolic process
AOT11_RS13345	COG0277	FAD linked oxidase domain protein
AOT11_RS13350	COG2020	methyltransferase activity
AOT11_RS13355	COG5640	endopeptidase activity
AOT11_RS13365	COG2986	histidine ammonia-lyase
AOT11_RS13370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AOT11_RS13380	COG1228	amidohydrolase
AOT11_RS13390	COG4326	sporulation control protein
AOT11_RS13410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AOT11_RS13490	COG0653	protein targeting
AOT11_RS13520	COG4628	conserved protein (DUF2132)
AOT11_RS13815	COG1942	4-Oxalocrotonate Tautomerase
AOT11_RS13845	COG0384	phenazine biosynthesis protein PhzF
AOT11_RS14290	COG0456	acetyltransferase
AOT11_RS14290	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AOT11_RS14440	COG2161	toxin-antitoxin pair type II binding
AOT11_RS14445	COG4115	mRNA cleavage
AOT11_RS14545	COG1942	4-Oxalocrotonate Tautomerase
AOT11_RS14690	COG4628	conserved protein (DUF2132)
AOT11_RS14865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AOT11_RS15060	COG0346	lactoylglutathione lyase activity
AOT11_RS15065	COG2026	Addiction module toxin, RelE StbE family
AOT11_RS15125	COG0534	Mate efflux family protein
AOT11_RS15130	COG0307	riboflavin synthase, alpha
AOT11_RS15150	COG3706	GGDEF domain
AOT11_RS15160	COG0791	NLP P60 protein
AOT11_RS15165	COG0840	transmembrane signaling receptor activity
AOT11_RS15175	COG3148	PFAM DTW domain containing protein
AOT11_RS15180	COG1940	carbohydrate kinase activity
AOT11_RS15195	COG0746	molybdenum cofactor guanylyltransferase activity
AOT11_RS15200	COG3842	ATPase activity
AOT11_RS15205	COG4662	Binding-protein-dependent transport system inner membrane component
AOT11_RS15215	COG2204	response regulator
AOT11_RS15220	COG3852	Histidine kinase
AOT11_RS15235	COG0488	(ABC) transporter
AOT11_RS15245	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AOT11_RS15275	COG0243	molybdopterin cofactor binding
AOT11_RS15275	COG3383	formate dehydrogenase (NAD+) activity
AOT11_RS15280	COG0437	4 iron, 4 sulfur cluster binding
AOT11_RS15310	COG0004	ammonium transporteR
AOT11_RS15315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AOT11_RS15320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AOT11_RS15330	COG1177	transmembrane transport
AOT11_RS15335	COG1176	ABC-type spermidine putrescine transport system, permease component I
AOT11_RS15345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT11_RS15360	COG2217	Heavy metal translocating P-type atpase
AOT11_RS15370	COG2010	Cytochrome c
AOT11_RS15385	COG3278	Belongs to the heme-copper respiratory oxidase family
AOT11_RS15400	COG0784	Response regulator, receiver
AOT11_RS15400	COG2205	protein histidine kinase activity
AOT11_RS15420	COG3120	sequence-specific DNA binding
AOT11_RS15425	COG1067	ATP-dependent peptidase activity
AOT11_RS15430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AOT11_RS15445	COG0488	(ABC) transporter
AOT11_RS15455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOT11_RS15455	COG0116	Belongs to the methyltransferase superfamily
AOT11_RS15470	COG2902	Dehydrogenase
AOT11_RS15480	COG0308	aminopeptidase N
AOT11_RS15495	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AOT11_RS15500	COG1956	GAF domain-containing protein
AOT11_RS15505	COG1132	(ABC) transporter
AOT11_RS15510	COG2995	paraquat-inducible protein a
AOT11_RS15515	COG3008	intermembrane lipid transfer
AOT11_RS15520	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AOT11_RS15520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AOT11_RS15525	COG2996	Protein conserved in bacteria
AOT11_RS15540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOT11_RS15550	COG3706	GGDEF domain
AOT11_RS15555	COG1793	dna ligase
AOT11_RS15560	COG1366	Belongs to the anti-sigma-factor antagonist family
AOT11_RS15590	COG2204	response regulator
AOT11_RS15635	COG0438	transferase activity, transferring glycosyl groups
AOT11_RS15645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOT11_RS15680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AOT11_RS15685	COG0363	glucosamine-6-phosphate deaminase activity
AOT11_RS15690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AOT11_RS15695	COG4565	transcriptional regulatory protein
AOT11_RS15700	COG3290	protein histidine kinase activity
AOT11_RS15715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT11_RS15745	COG1115	amino acid carrier protein
AOT11_RS15760	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AOT11_RS15765	COG0204	Acyl-transferase
AOT11_RS15770	COG0348	domain, Protein
AOT11_RS15775	COG0437	4 iron, 4 sulfur cluster binding
AOT11_RS15785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT11_RS15790	COG4597	amino acid ABC transporter
AOT11_RS15795	COG0765	amino acid transport
AOT11_RS15800	COG1126	abc transporter atp-binding protein
AOT11_RS15805	COG0670	Belongs to the BI1 family
AOT11_RS15810	COG2920	part of a sulfur-relay system
AOT11_RS15825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOT11_RS15890	COG3842	ATPase activity
AOT11_RS15895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOT11_RS15905	COG1596	polysaccharide export
AOT11_RS15975	COG0714	Associated with various cellular activities
AOT11_RS15995	COG2304	oxidoreductase activity
AOT11_RS16005	COG5001	Diguanylate cyclase
AOT11_RS16005	COG4251	negative regulation of phosphorylation
AOT11_RS16005	COG3706	GGDEF domain
AOT11_RS16005	COG2203	Gaf domain
AOT11_RS16010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AOT11_RS16015	COG0581	inorganic phosphate transmembrane transporter activity
AOT11_RS16020	COG0573	inorganic phosphate transmembrane transporter activity
AOT11_RS16065	COG0513	Belongs to the DEAD box helicase family
AOT11_RS16075	COG1388	LysM domain
AOT11_RS16075	COG1376	ErfK ybiS ycfS ynhG family protein
AOT11_RS16080	COG0415	Belongs to the DNA photolyase family
AOT11_RS16085	COG0789	Transcriptional regulator
AOT11_RS16090	COG3272	Protein of unknown function (DUF1722)
AOT11_RS16095	COG0813	purine-nucleoside phosphorylase activity
AOT11_RS16120	COG1566	PFAM secretion protein HlyD family protein
AOT11_RS16125	COG4720	Psort location CytoplasmicMembrane, score
AOT11_RS16130	COG1122	ATPase activity
AOT11_RS16145	COG0793	Belongs to the peptidase S41A family
AOT11_RS16145	COG4946	Tricorn protease homolog
AOT11_RS16150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOT11_RS16175	COG0668	transmembrane transport
AOT11_RS16195	COG1538	Outer membrane efflux protein
AOT11_RS16205	COG2274	protein secretion by the type I secretion system
AOT11_RS16215	COG3111	PFAM Bacterial OB fold (BOF) protein
AOT11_RS16265	COG3040	lipid binding
AOT11_RS16320	COG3240	lipase activity
AOT11_RS16335	COG2211	Major facilitator Superfamily
AOT11_RS16345	COG0346	lactoylglutathione lyase activity
AOT11_RS16365	COG0753	catalase activity
AOT11_RS16385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AOT11_RS16395	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AOT11_RS16410	COG0393	Putative heavy-metal-binding
AOT11_RS16430	COG4771	TonB-dependent receptor
AOT11_RS16435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AOT11_RS16440	COG0039	L-malate dehydrogenase activity
AOT11_RS16455	COG2814	Major facilitator Superfamily
AOT11_RS16520	COG0351	phosphomethylpyrimidine kinase
AOT11_RS16525	COG0671	phosphoesterase, PA-phosphatase related
AOT11_RS16540	COG0561	phosphatase activity
AOT11_RS16550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AOT11_RS16555	COG0076	glutamate decarboxylase activity
AOT11_RS16560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOT11_RS16585	COG4221	oxidoreductase activity
AOT11_RS16600	COG0745	RESPONSE REGULATOR receiver
AOT11_RS16605	COG2205	protein histidine kinase activity
AOT11_RS16610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AOT11_RS16615	COG2194	sulfuric ester hydrolase activity
AOT11_RS16620	COG1368	sulfuric ester hydrolase activity
AOT11_RS16635	COG2356	endonuclease I
AOT11_RS16650	COG3706	GGDEF domain
AOT11_RS16660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOT11_RS16695	COG2175	clavaminate synthase activity
AOT11_RS16700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOT11_RS16745	COG1301	dicarboxylic acid transport
AOT11_RS16755	COG0137	argininosuccinate synthase activity
AOT11_RS16770	COG0583	DNA-binding transcription factor activity
AOT11_RS16790	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AOT11_RS16815	COG4934	collagen metabolic process
AOT11_RS16825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AOT11_RS16830	COG1482	cell wall glycoprotein biosynthetic process
AOT11_RS16835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AOT11_RS16840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AOT11_RS16840	COG1263	PTS System
AOT11_RS16845	COG1609	Transcriptional regulator
AOT11_RS16855	COG3383	formate dehydrogenase (NAD+) activity
AOT11_RS16870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT11_RS16870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT11_RS16870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT11_RS16875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT11_RS16885	COG3537	Alpha-1,2-mannosidase
AOT11_RS16895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT11_RS16900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT11_RS16910	COG2207	Transcriptional regulator
AOT11_RS16915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT11_RS16915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT11_RS16915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT11_RS16920	COG1482	cell wall glycoprotein biosynthetic process
AOT11_RS16970	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AOT11_RS16975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AOT11_RS16980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT11_RS16985	COG2211	Major facilitator Superfamily
AOT11_RS17010	COG1129	ABC transporter
AOT11_RS17020	COG1609	Transcriptional regulator
AOT11_RS17045	COG0564	pseudouridine synthase activity
AOT11_RS17070	COG1566	PFAM secretion protein HlyD family protein
AOT11_RS17080	COG0534	Mate efflux family protein
AOT11_RS17085	COG1472	Belongs to the glycosyl hydrolase 3 family
AOT11_RS17100	COG4580	involved in the transport of maltose and maltodextrins
AOT11_RS17115	COG1609	Transcriptional regulator
AOT11_RS17125	COG4608	Belongs to the ABC transporter superfamily
AOT11_RS17130	COG0444	Belongs to the ABC transporter superfamily
AOT11_RS17135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOT11_RS17145	COG0747	negative chemotaxis
AOT11_RS17155	COG1609	Transcriptional regulator
AOT11_RS17160	COG3842	ATPase activity
AOT11_RS17165	COG2723	6-phospho-beta-galactosidase activity
AOT11_RS17170	COG0395	ABC-type sugar transport system, permease component
AOT11_RS17185	COG1609	Transcriptional regulator
AOT11_RS17205	COG2199	diguanylate cyclase activity
AOT11_RS17215	COG0642	Histidine kinase
AOT11_RS17225	COG0583	DNA-binding transcription factor activity
AOT11_RS17235	COG0612	Peptidase, M16
AOT11_RS17240	COG1283	sodium-dependent phosphate transmembrane transporter activity
AOT11_RS17245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AOT11_RS17250	COG0625	glutathione transferase activity
AOT11_RS17255	COG1012	belongs to the aldehyde dehydrogenase family
AOT11_RS17305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOT11_RS17310	COG0840	transmembrane signaling receptor activity
AOT11_RS17320	COG1640	4-alpha-glucanotransferase
AOT11_RS17325	COG0058	SHG alpha-glucan phosphorylase activity
AOT11_RS17330	COG2909	trisaccharide binding
AOT11_RS17350	COG3842	ATPase activity
AOT11_RS17360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT11_RS17370	COG2182	Extracellular solute-binding protein
AOT11_RS17375	COG1175	transmembrane transport
AOT11_RS17380	COG3833	ABC-type maltose transport systems, permease component
AOT11_RS17415	COG1999	signal sequence binding
AOT11_RS17420	COG2847	Copper chaperone PCu(A)C
AOT11_RS17425	COG1162	GTPase activity
AOT11_RS17430	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AOT11_RS17440	COG0531	amino acid
AOT11_RS17445	COG1982	Orn Lys Arg decarboxylase major
AOT11_RS17500	COG3706	GGDEF domain
AOT11_RS17505	COG5001	Diguanylate cyclase
AOT11_RS17515	COG1741	Belongs to the pirin family
AOT11_RS17525	COG3123	guanosine phosphorylase activity
AOT11_RS17545	COG1309	transcriptional regulator
AOT11_RS17565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AOT11_RS17570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOT11_RS17575	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AOT11_RS17605	COG0363	glucosamine-6-phosphate deaminase activity
AOT11_RS17615	COG0786	glutamate:sodium symporter activity
AOT11_RS17620	COG0786	glutamate:sodium symporter activity
AOT11_RS17645	COG3275	phosphorelay sensor kinase activity
AOT11_RS17660	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOT11_RS17665	COG1136	(ABC) transporter
AOT11_RS17680	COG0217	transcriptional regulatory protein
AOT11_RS17700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AOT11_RS17700	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AOT11_RS17710	COG0444	Belongs to the ABC transporter superfamily
AOT11_RS17715	COG4608	Belongs to the ABC transporter superfamily
AOT11_RS17740	COG1444	tRNA N-acetyltransferase activity
AOT11_RS17750	COG0745	RESPONSE REGULATOR receiver
AOT11_RS17765	COG0835	chemotaxis
AOT11_RS17770	COG0840	transmembrane signaling receptor activity
AOT11_RS17775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AOT11_RS17780	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AOT11_RS17785	COG2201	protein-glutamate methylesterase activity
AOT11_RS17790	COG0840	transmembrane signaling receptor activity
AOT11_RS17845	COG0406	alpha-ribazole phosphatase activity
AOT11_RS17865	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AOT11_RS17870	COG1737	Transcriptional regulator
AOT11_RS17875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AOT11_RS17875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AOT11_RS17885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AOT11_RS17890	COG0459	protein refolding
AOT11_RS17910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AOT11_RS17915	COG3069	C4-dicarboxylate transmembrane transporter activity
AOT11_RS17945	COG2204	response regulator
AOT11_RS17955	COG0259	pyridoxamine-phosphate oxidase activity
AOT11_RS18010	COG1132	(ABC) transporter
AOT11_RS18025	COG3623	hexulose-6-phosphate isomerase
AOT11_RS18030	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AOT11_RS18035	COG0561	phosphatase activity
AOT11_RS18065	COG1902	pentaerythritol trinitrate reductase activity
AOT11_RS18075	COG2814	Major facilitator Superfamily
AOT11_RS18080	COG1028	Short-chain dehydrogenase reductase Sdr
AOT11_RS18095	COG0800	Aldolase
AOT11_RS18100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT11_RS18105	COG1904	glucuronate isomerase
AOT11_RS18110	COG0246	Mannitol dehydrogenase
AOT11_RS18120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AOT11_RS18130	COG2186	Transcriptional regulator
AOT11_RS18140	COG0513	Belongs to the DEAD box helicase family
AOT11_RS18145	COG1609	Transcriptional regulator
AOT11_RS18175	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AOT11_RS18180	COG0732	type I restriction modification DNA specificity domain
AOT11_RS18185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOT11_RS18195	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AOT11_RS18200	COG2258	MOSC domain
AOT11_RS18230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AOT11_RS18245	COG0840	transmembrane signaling receptor activity
AOT11_RS18265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT11_RS18270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT11_RS18320	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AOT11_RS18335	COG1349	DNA-binding transcription factor activity
AOT11_RS18345	COG1349	DNA-binding transcription factor activity
AOT11_RS18355	COG2222	sugar isomerase
AOT11_RS18360	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AOT11_RS18370	COG3716	PTS system mannose fructose sorbose family IID component
AOT11_RS18375	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT11_RS18405	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AOT11_RS18410	COG1120	ATPase activity
AOT11_RS18440	COG1136	(ABC) transporter
AOT11_RS18440	COG0577	efflux transmembrane transporter activity
AOT11_RS18445	COG0577	efflux transmembrane transporter activity
AOT11_RS18445	COG1136	(ABC) transporter
AOT11_RS18450	COG2176	DNA-directed DNA polymerase activity
AOT11_RS18505	COG2205	protein histidine kinase activity
AOT11_RS18520	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AOT11_RS18555	COG0579	oxidoreductase
AOT11_RS18565	COG3437	response regulator, receiver
AOT11_RS18585	COG1357	PFAM Pentapeptide repeats (8 copies)
AOT11_RS18595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOT11_RS18630	COG0513	Belongs to the DEAD box helicase family
AOT11_RS18650	COG0583	DNA-binding transcription factor activity
AOT11_RS18660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOT11_RS18690	COG2814	Major facilitator Superfamily
AOT11_RS18695	COG2207	Transcriptional regulator
AOT11_RS18710	COG1858	cytochrome C peroxidase
AOT11_RS18735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AOT11_RS18745	COG0454	-acetyltransferase
AOT11_RS18775	COG3046	protein related to deoxyribodipyrimidine photolyase
AOT11_RS18780	COG2207	Transcriptional regulator
AOT11_RS18785	COG1881	PFAM PEBP family protein
AOT11_RS18790	COG0494	nUDIX hydrolase
AOT11_RS18830	COG0668	transmembrane transport
AOT11_RS18870	COG1028	Short-chain dehydrogenase reductase Sdr
AOT11_RS18880	COG1917	Cupin 2, conserved barrel domain protein
AOT11_RS18895	COG0729	surface antigen
AOT11_RS18900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT11_RS18905	COG2272	Belongs to the type-B carboxylesterase lipase family
AOT11_RS18930	COG2985	domain, Protein
AOT11_RS18940	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AOT11_RS18955	COG0583	DNA-binding transcription factor activity
AOT11_RS18965	COG0697	spore germination
AOT11_RS18970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT11_RS18975	COG0800	Aldolase
AOT11_RS18980	COG0366	Alpha amylase catalytic
AOT11_RS18990	COG3366	ferrous iron transmembrane transporter activity
AOT11_RS18995	COG0700	Nucleoside recognition
AOT11_RS19000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOT11_RS19015	COG0798	PFAM Bile acid sodium symporter
AOT11_RS19030	COG2194	sulfuric ester hydrolase activity
AOT11_RS19035	COG0583	DNA-binding transcription factor activity
AOT11_RS19045	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AOT11_RS19070	COG0673	inositol 2-dehydrogenase activity
AOT11_RS19075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOT11_RS19080	COG2197	response regulator
AOT11_RS19085	COG0384	phenazine biosynthesis protein PhzF
AOT11_RS19095	COG0625	glutathione transferase activity
AOT11_RS19100	COG1879	ABC-type sugar transport system periplasmic component
AOT11_RS19110	COG3284	Transcriptional regulator
AOT11_RS19115	COG1012	belongs to the aldehyde dehydrogenase family
AOT11_RS19120	COG1253	flavin adenine dinucleotide binding
AOT11_RS19130	COG0242	peptide deformylase activity
AOT11_RS19145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT11_RS19150	COG1609	Transcriptional regulator
AOT11_RS19165	COG0488	(ABC) transporter
AOT11_RS19170	COG0814	amino acid
AOT11_RS19175	COG3033	Beta-eliminating lyase
AOT11_RS19190	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT11_RS19215	COG4067	protein conserved in archaea
AOT11_RS19215	COG0189	ligase activity
AOT11_RS19220	COG0189	ligase activity
AOT11_RS19230	COG1629	transport
AOT11_RS19230	COG4774	siderophore transport
AOT11_RS19235	COG4607	ABC-type enterochelin transport system periplasmic component
AOT11_RS19245	COG1021	2,3-dihydroxybenzoate-AMP ligase
AOT11_RS19265	COG1021	2,3-dihydroxybenzoate-AMP ligase
AOT11_RS19270	COG1169	isochorismate synthase
AOT11_RS19275	COG1028	Short-chain dehydrogenase reductase Sdr
AOT11_RS19280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOT11_RS19310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT11_RS19315	COG0840	transmembrane signaling receptor activity
AOT11_RS19325	COG2755	lipolytic protein G-D-S-L family
AOT11_RS19330	COG5001	Diguanylate cyclase
AOT11_RS19330	COG5002	protein histidine kinase activity
AOT11_RS19345	COG4160	amino acid transport
AOT11_RS19350	COG4215	(ABC) transporter
AOT11_RS19355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT11_RS19360	COG1126	abc transporter atp-binding protein
AOT11_RS19365	COG3015	lipoprotein NlpE involved in copper resistance
AOT11_RS19380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AOT11_RS19425	COG2814	Major facilitator Superfamily
AOT11_RS19455	COG1139	Iron-sulfur cluster binding protein
AOT11_RS19465	COG1620	l-lactate permease
AOT11_RS19470	COG0583	DNA-binding transcription factor activity
AOT11_RS19475	COG1505	serine-type exopeptidase activity
AOT11_RS19480	COG4172	Belongs to the ABC transporter superfamily
AOT11_RS19490	COG1067	ATP-dependent peptidase activity
AOT11_RS19495	COG0402	S-adenosylhomocysteine deaminase activity
AOT11_RS19500	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AOT11_RS19510	COG2239	Acts as a magnesium transporter
AOT11_RS19540	COG0121	glutamine amidotransferase
AOT11_RS19550	COG1522	sequence-specific DNA binding
AOT11_RS19570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOT11_RS19575	COG0583	DNA-binding transcription factor activity
AOT11_RS19600	COG0784	Response regulator, receiver
AOT11_RS19600	COG5002	protein histidine kinase activity
AOT11_RS19600	COG2205	protein histidine kinase activity
AOT11_RS19615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AOT11_RS19640	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AOT11_RS19650	COG0383	alpha-mannosidase activity
AOT11_RS19670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT11_RS19685	COG1482	cell wall glycoprotein biosynthetic process
AOT11_RS19695	COG2926	Belongs to the UPF0265 family
AOT11_RS19705	COG3132	Protein of unknown function, DUF480
AOT11_RS19710	COG2827	Endonuclease containing a URI domain
AOT11_RS19770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOT11_RS19775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOT11_RS19785	COG0183	Belongs to the thiolase family
AOT11_RS19810	COG3005	denitrification pathway
AOT11_RS19820	COG0243	molybdopterin cofactor binding
AOT11_RS19830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOT11_RS19835	COG3850	Histidine kinase
AOT11_RS19840	COG2197	response regulator
AOT11_RS19860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AOT11_RS19860	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AOT11_RS19870	COG0516	GMP reductase activity
AOT11_RS19885	COG1538	Outer membrane efflux protein
AOT11_RS19890	COG1566	PFAM secretion protein HlyD family protein
AOT11_RS19935	COG0183	Belongs to the thiolase family
AOT11_RS19945	COG0427	acetyl-CoA hydrolase
AOT11_RS19980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOT11_RS19995	COG3568	Endonuclease Exonuclease Phosphatase
AOT11_RS20020	COG0513	Belongs to the DEAD box helicase family
AOT11_RS20035	COG1846	Transcriptional regulator
AOT11_RS20070	COG0842	Transport permease protein
AOT11_RS20075	COG1131	(ABC) transporter
AOT11_RS20085	COG1737	Transcriptional regulator
AOT11_RS20085	COG0837	glucose binding
AOT11_RS20095	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AOT11_RS20120	COG0251	oxidation-reduction process
AOT11_RS20125	COG3706	GGDEF domain
AOT11_RS20125	COG4251	negative regulation of phosphorylation
AOT11_RS20125	COG2203	Gaf domain
AOT11_RS20125	COG5001	Diguanylate cyclase
AOT11_RS20130	COG0583	DNA-binding transcription factor activity
AOT11_RS20135	COG2814	Major facilitator Superfamily
AOT11_RS20155	COG0697	spore germination
AOT11_RS20170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT11_RS20180	COG1764	response to oxidative stress
AOT11_RS20185	COG1846	Transcriptional regulator
AOT11_RS20210	COG1280	lysine exporter protein (LysE YggA)
AOT11_RS20220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT11_RS20225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AOT11_RS20230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOT11_RS20235	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AOT11_RS20260	COG1612	heme a metabolic process
AOT11_RS20265	COG0109	protoheme IX farnesyltransferase activity
AOT11_RS20275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOT11_RS20280	COG0840	transmembrane signaling receptor activity
AOT11_RS20295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AOT11_RS20300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AOT11_RS20320	COG2897	thiosulfate sulfurtransferase activity
AOT11_RS20330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AOT11_RS20335	COG0303	'Molybdopterin
AOT11_RS20340	COG0302	gtp cyclohydrolase
AOT11_RS20350	COG0038	chloride channel
AOT11_RS20365	COG4989	oxidoreductase activity
AOT11_RS20375	COG2195	Cleaves the N-terminal amino acid of tripeptides
AOT11_RS20395	COG0840	transmembrane signaling receptor activity
AOT11_RS20400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOT11_RS20405	COG0545	Peptidyl-prolyl cis-trans isomerase
AOT11_RS20435	COG1278	Cold shock
AOT11_RS20440	COG3036	rescue of stalled ribosome
AOT11_RS20450	COG2199	diguanylate cyclase activity
AOT11_RS20450	COG2203	Gaf domain
AOT11_RS20460	COG1482	cell wall glycoprotein biosynthetic process
AOT11_RS20465	COG2271	Major facilitator Superfamily
AOT11_RS20470	COG3851	Histidine kinase
AOT11_RS20475	COG2197	response regulator
AOT11_RS20495	COG2130	NADP-dependent
AOT11_RS20500	COG1309	transcriptional regulator
AOT11_RS20515	COG1278	Cold shock
AOT11_RS20535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AOT11_RS20540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOT11_RS20545	COG1960	acyl-CoA dehydrogenase activity
AOT11_RS20555	COG0183	Belongs to the thiolase family
AOT11_RS20570	COG1024	Enoyl-CoA hydratase
AOT11_RS20575	COG1024	Enoyl-CoA hydratase
AOT11_RS20585	COG1028	Short-chain dehydrogenase reductase Sdr
AOT11_RS20595	COG5642	Protein of unknown function (DUF2384)
AOT11_RS20630	COG2994	toxin metabolic process
AOT11_RS20635	COG3064	Membrane
AOT11_RS20635	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AOT11_RS20635	COG1073	alpha beta
AOT11_RS20695	COG3437	response regulator, receiver
AOT11_RS20695	COG0784	Response regulator, receiver
AOT11_RS20700	COG4191	Histidine kinase
AOT11_RS20700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT11_RS20710	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AOT11_RS20735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOT11_RS20740	COG3186	Phenylalanine-4-hydroxylase
AOT11_RS20745	COG2154	pterin-4-alpha-carbinolamine dehydratase
AOT11_RS20765	COG3530	Putative quorum-sensing-regulated virulence factor
AOT11_RS20785	COG0515	serine threonine protein kinase
AOT11_RS20785	COG2815	serine threonine protein kinase
AOT11_RS20820	COG0631	protein serine/threonine phosphatase activity
AOT11_RS20900	COG3209	COG3209 Rhs family protein
AOT11_RS20905	COG5444	nuclease activity
AOT11_RS20925	COG0501	Belongs to the peptidase M48B family
AOT11_RS20930	COG1704	LemA family
AOT11_RS20935	COG3069	C4-dicarboxylate transmembrane transporter activity
AOT11_RS20945	COG0312	modulator of DNA gyrase
AOT11_RS20950	COG0312	modulator of DNA gyrase
AOT11_RS20955	COG0584	glycerophosphoryl diester phosphodiesterase
AOT11_RS20960	COG2271	Major facilitator Superfamily
AOT11_RS20985	COG0366	Alpha amylase catalytic
AOT11_RS20995	COG0243	molybdopterin cofactor binding
AOT11_RS21000	COG1648	precorrin-2 dehydrogenase activity
AOT11_RS21000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AOT11_RS21015	COG3707	response regulator
AOT11_RS21020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOT11_RS21020	COG1116	anion transmembrane transporter activity
AOT11_RS21025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOT11_RS21030	COG1116	anion transmembrane transporter activity
AOT11_RS21035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT11_RS21035	COG2146	nitrite reductase [NAD(P)H] activity
AOT11_RS21050	COG2203	Gaf domain
AOT11_RS21050	COG2199	diguanylate cyclase activity
AOT11_RS21060	COG0523	cobalamin synthesis protein
AOT11_RS21070	COG0513	Belongs to the DEAD box helicase family
AOT11_RS21075	COG0010	Belongs to the arginase family
AOT11_RS21085	COG4251	negative regulation of phosphorylation
AOT11_RS21085	COG2203	Gaf domain
AOT11_RS21085	COG3706	GGDEF domain
AOT11_RS21085	COG5001	Diguanylate cyclase
AOT11_RS21095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AOT11_RS21125	COG0840	transmembrane signaling receptor activity
AOT11_RS21130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT11_RS21165	COG0811	peptide transport
AOT11_RS21170	COG0811	peptide transport
AOT11_RS21175	COG0848	biopolymer transport protein
AOT11_RS21190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AOT11_RS21195	COG0840	transmembrane signaling receptor activity
AOT11_RS21210	COG0534	Mate efflux family protein
AOT11_RS21225	COG3118	belongs to the thioredoxin family
AOT11_RS21230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AOT11_RS21285	COG1328	CTP reductase activity
AOT11_RS21290	COG0602	queuosine metabolic process
AOT11_RS21300	COG4067	protein conserved in archaea
AOT11_RS21300	COG0189	ligase activity
AOT11_RS21325	COG0725	ABC transporter, periplasmic molybdate-binding protein
AOT11_RS21330	COG4149	molybdate abc transporter
AOT11_RS21340	COG0697	spore germination
AOT11_RS21345	COG1846	Transcriptional regulator
AOT11_RS21355	COG2199	diguanylate cyclase activity
AOT11_RS21365	COG3706	GGDEF domain
AOT11_RS21385	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AOT11_RS21395	COG0745	RESPONSE REGULATOR receiver
AOT11_RS21410	COG3140	Belongs to the UPF0181 family
AOT11_RS21415	COG0023	Translation Initiation Factor
AOT11_RS21425	COG1181	Belongs to the D-alanine--D-alanine ligase family
AOT11_RS21435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOT11_RS21435	COG1042	CoA-binding domain protein
AOT11_RS21435	COG0045	succinate-CoA ligase (ADP-forming) activity
AOT11_RS21440	COG0583	DNA-binding transcription factor activity
AOT11_RS21450	COG3447	MASE1 domain protein
AOT11_RS21450	COG5001	Diguanylate cyclase
AOT11_RS21450	COG5002	protein histidine kinase activity
AOT11_RS21460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AOT11_RS21465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AOT11_RS21470	COG1984	allophanate hydrolase subunit 2
AOT11_RS21475	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AOT11_RS21475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT11_RS21480	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AOT11_RS21485	COG4181	ATPase activity
AOT11_RS21495	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AOT11_RS21500	COG1716	ATPase activity
AOT11_RS21500	COG5001	Diguanylate cyclase
AOT11_RS21515	COG0484	heat shock protein binding
AOT11_RS21535	COG0583	DNA-binding transcription factor activity
AOT11_RS21540	COG0366	Alpha amylase catalytic
AOT11_RS21550	COG4533	DNA binding
AOT11_RS21560	COG2050	protein possibly involved in aromatic compounds catabolism
AOT11_RS21575	COG2067	long-chain fatty acid transport protein
AOT11_RS21580	COG2267	carboxylic ester hydrolase activity
AOT11_RS21610	COG0861	Integral membrane protein TerC family
AOT11_RS21615	COG0737	Belongs to the 5'-nucleotidase family
AOT11_RS21620	COG3593	DNA synthesis involved in DNA repair
AOT11_RS21630	COG0583	DNA-binding transcription factor activity
AOT11_RS21635	COG2116	formate transmembrane transporter activity
AOT11_RS21640	COG2353	YceI-like domain
AOT11_RS21645	COG3038	cytochrome b561
AOT11_RS21660	COG0513	Belongs to the DEAD box helicase family
AOT11_RS21680	COG0546	phosphoglycolate phosphatase activity
AOT11_RS21685	COG3437	response regulator, receiver
AOT11_RS21685	COG0784	Response regulator, receiver
AOT11_RS21700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT11_RS21705	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AOT11_RS21710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AOT11_RS21720	COG2207	Transcriptional regulator
AOT11_RS21725	COG1979	alcohol dehydrogenase
AOT11_RS21735	COG4191	Histidine kinase
AOT11_RS21745	COG2271	Major facilitator Superfamily
AOT11_RS21750	COG0469	pyruvate kinase activity
AOT11_RS21775	COG1609	Transcriptional regulator
AOT11_RS21780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT11_RS21780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT11_RS21785	COG1105	Belongs to the carbohydrate kinase PfkB family
AOT11_RS21790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT11_RS21790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT11_RS21790	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AOT11_RS21835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOT11_RS21840	COG0509	glycine decarboxylation via glycine cleavage system
AOT11_RS21855	COG0556	nucleotide-excision repair
AOT11_RS21885	COG1132	(ABC) transporter
AOT11_RS21895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOT11_RS21910	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOT11_RS21915	COG0583	DNA-binding transcription factor activity
AOT11_RS21935	COG2814	Major facilitator Superfamily
AOT11_RS21965	COG0641	radical SAM
AOT11_RS21975	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
AOT11_RS22010	COG0714	Associated with various cellular activities
AOT11_RS22030	COG3119	arylsulfatase activity
AOT11_RS22035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AOT11_RS22040	COG0513	Belongs to the DEAD box helicase family
AOT11_RS22045	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AOT11_RS22060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOT11_RS22090	COG5001	Diguanylate cyclase
AOT11_RS22090	COG1716	ATPase activity
AOT11_RS22100	COG0513	Belongs to the DEAD box helicase family
AOT11_RS22125	COG3005	denitrification pathway
AOT11_RS22130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOT11_RS22160	COG1879	ABC-type sugar transport system periplasmic component
AOT11_RS22165	COG1803	Methylglyoxal synthase
AOT11_RS22170	COG0210	DNA helicase
AOT11_RS22175	COG1289	transmembrane transporter activity
AOT11_RS22205	COG0789	Transcriptional regulator
AOT11_RS22210	COG4604	ABC transporter, ATP-binding protein
AOT11_RS22215	COG4605	iron ion homeostasis
AOT11_RS22220	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOT11_RS22240	COG0110	maltose O-acetyltransferase activity
AOT11_RS22250	COG3290	protein histidine kinase activity
AOT11_RS22255	COG0471	metal ion transport
AOT11_RS22340	COG4964	Belongs to the GSP D family
AOT11_RS22360	COG0583	DNA-binding transcription factor activity
AOT11_RS22370	COG0419	ATPase involved in DNA repair
AOT11_RS22375	COG0420	3'-5' exonuclease activity
AOT11_RS22390	COG0456	acetyltransferase
AOT11_RS22400	COG0835	chemotaxis
AOT11_RS22400	COG0784	Response regulator, receiver
AOT11_RS22410	COG1609	Transcriptional regulator
AOT11_RS22415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT11_RS22420	COG1879	ABC-type sugar transport system periplasmic component
AOT11_RS22425	COG1172	Belongs to the binding-protein-dependent transport system permease family
AOT11_RS22430	COG1129	ABC transporter
AOT11_RS22435	COG1869	D-ribose catabolic process
AOT11_RS22450	COG2315	Protein conserved in bacteria
AOT11_RS22455	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AOT11_RS22470	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AOT11_RS22485	COG1288	antiporter activity
AOT11_RS22495	COG0671	phosphoesterase, PA-phosphatase related
AOT11_RS22510	COG2962	Rard protein
AOT11_RS22535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOT11_RS22540	COG0814	amino acid
AOT11_RS22565	COG3174	membrane
AOT11_RS22570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT11_RS22605	COG0443	Heat shock 70 kDa protein
AOT11_RS22610	COG1454	alcohol dehydrogenase
AOT11_RS22620	COG2133	pyrroloquinoline quinone binding
AOT11_RS22625	COG1619	proteins homologs of microcin C7 resistance protein MccF
AOT11_RS22640	COG0247	lactate metabolic process
AOT11_RS22645	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AOT11_RS22650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AOT11_RS22670	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AOT11_RS22680	COG3059	membrane
AOT11_RS22685	COG4175	Glycine betaine
AOT11_RS22710	COG1309	transcriptional regulator
AOT11_RS22730	COG1686	Belongs to the peptidase S11 family
AOT11_RS22750	COG1760	l-serine dehydratase
AOT11_RS22755	COG3104	oligopeptide transport
AOT11_RS22765	COG0583	DNA-binding transcription factor activity
AOT11_RS22770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT11_RS22790	COG3842	ATPase activity
AOT11_RS22795	COG1840	ABC-type Fe3 transport system, periplasmic component
AOT11_RS22800	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AOT11_RS22805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOT11_RS22815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AOT11_RS22815	COG2207	Transcriptional regulator
AOT11_RS22820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOT11_RS22845	COG1011	Hydrolase
AOT11_RS22870	COG1765	OsmC-like protein
AOT11_RS22875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT11_RS22875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT11_RS22880	COG3706	GGDEF domain
AOT11_RS22895	COG0840	transmembrane signaling receptor activity
AOT11_RS22915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AOT11_RS22935	COG2084	Dehydrogenase
AOT11_RS22950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOT11_RS22955	COG0739	heme binding
AOT11_RS22975	COG3314	Sporulation integral membrane protein YlbJ
AOT11_RS22990	COG0840	transmembrane signaling receptor activity
AOT11_RS23000	COG0366	Alpha amylase catalytic
AOT11_RS23005	COG0589	response to stress
AOT11_RS23010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT11_RS23015	COG0784	Response regulator, receiver
AOT11_RS23015	COG0835	chemotaxis
AOT11_RS23025	COG0748	coenzyme F420 binding
AOT11_RS23030	COG3721	Heme iron utilization protein
AOT11_RS23040	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AOT11_RS23045	COG0811	peptide transport
AOT11_RS23050	COG0848	biopolymer transport protein
AOT11_RS23060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOT11_RS23065	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AOT11_RS23110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AOT11_RS23115	COG3217	Mosc domain protein beta barrel domain protein
AOT11_RS23115	COG0633	Ferredoxin
AOT11_RS23115	COG3217	Mosc domain protein beta barrel domain protein
AOT11_RS23115	COG0633	Ferredoxin
AOT11_RS23120	COG0418	dihydroorotase activity
AOT11_RS23130	COG2354	Protein conserved in bacteria
AOT11_RS23160	COG3833	ABC-type maltose transport systems, permease component
AOT11_RS23165	COG1175	transmembrane transport
AOT11_RS23180	COG3842	ATPase activity
AOT11_RS23185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOT11_RS23195	COG1596	polysaccharide export