locus-tag	class	description
VV_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VV_RS00075	COG0187	DNA topoisomerase II activity
VV_RS00120	COG1024	Enoyl-CoA hydratase
VV_RS00120	COG1250	3-hydroxyacyl-CoA dehydrogenase
VV_RS00235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV_RS00280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VV_RS00285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VV_RS00290	COG0706	membrane insertase activity
VV_RS00295	COG0594	ribonuclease P activity
VV_RS00300	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VV_RS00305	COG1126	abc transporter atp-binding protein
VV_RS00320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VV_RS00325	COG0592	DNA-directed DNA polymerase activity
VV_RS00330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VV_RS00335	COG0187	DNA topoisomerase II activity
VV_RS00340	COG0071	Belongs to the small heat shock protein (HSP20) family
VV_RS00350	COG3977	Valine--pyruvate aminotransferase
VV_RS00360	COG0751	glycine-tRNA ligase activity
VV_RS00365	COG0752	glycyl-tRNA synthetase alpha subunit
VV_RS00370	COG2119	membrane
VV_RS00380	COG0425	Belongs to the sulfur carrier protein TusA family
VV_RS00395	COG0604	alcohol dehydrogenase
VV_RS00400	COG0183	Belongs to the thiolase family
VV_RS00405	COG1250	3-hydroxyacyl-CoA dehydrogenase
VV_RS00405	COG1024	Enoyl-CoA hydratase
VV_RS00410	COG1739	Uncharacterized protein family UPF0029
VV_RS00415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV_RS00460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VV_RS00465	COG2960	long-chain fatty acid transporting porin activity
VV_RS00470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV_RS00475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV_RS00480	COG1309	transcriptional regulator
VV_RS00520	COG4172	Belongs to the ABC transporter superfamily
VV_RS00525	COG4166	transmembrane transport
VV_RS00530	COG0601	transmembrane transport
VV_RS00535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV_RS00570	COG2815	serine threonine protein kinase
VV_RS00570	COG0515	serine threonine protein kinase
VV_RS00580	COG0745	RESPONSE REGULATOR receiver
VV_RS00585	COG1609	Transcriptional regulator
VV_RS00590	COG0129	dihydroxy-acid dehydratase activity
VV_RS00595	COG3265	gluconokinase activity
VV_RS00605	COG0800	Aldolase
VV_RS00625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV_RS00630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VV_RS00640	COG1522	sequence-specific DNA binding
VV_RS00645	COG5002	protein histidine kinase activity
VV_RS00645	COG5001	Diguanylate cyclase
VV_RS00650	COG0742	ribosomal rna small subunit methyltransferase
VV_RS00665	COG0589	response to stress
VV_RS00670	COG1528	Iron-storage protein
VV_RS00680	COG2081	HI0933 family
VV_RS00690	COG2959	enzyme of heme biosynthesis
VV_RS00700	COG0181	hydroxymethylbilane synthase activity
VV_RS00705	COG3072	Adenylate cyclase
VV_RS00710	COG1965	Belongs to the frataxin family
VV_RS00720	COG0019	diaminopimelate decarboxylase activity
VV_RS00725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VV_RS00735	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VV_RS00740	COG1011	Hydrolase
VV_RS00745	COG3287	FIST C domain
VV_RS00745	COG2200	EAL domain
VV_RS00745	COG2199	diguanylate cyclase activity
VV_RS00750	COG3148	PFAM DTW domain containing protein
VV_RS00765	COG0561	phosphatase activity
VV_RS00770	COG2267	carboxylic ester hydrolase activity
VV_RS00775	COG1280	lysine exporter protein (LysE YggA)
VV_RS00780	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VV_RS00785	COG0640	Transcriptional regulator
VV_RS00790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VV_RS00830	COG2095	MarC family integral membrane protein
VV_RS00840	COG0742	ribosomal rna small subunit methyltransferase
VV_RS00845	COG0552	protein localization to endoplasmic reticulum
VV_RS00850	COG2884	Cell division ATP-binding protein ftsE
VV_RS00855	COG2177	Part of the ABC transporter FtsEX involved in
VV_RS00865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV_RS00875	COG1580	Controls the rotational direction of flagella during chemotaxis
VV_RS00880	COG3161	chorismate lyase activity
VV_RS00885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VV_RS00890	COG2937	Belongs to the GPAT DAPAT family
VV_RS00895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VV_RS00905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV_RS00920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VV_RS00950	COG0789	Transcriptional regulator
VV_RS00970	COG1566	PFAM secretion protein HlyD family protein
VV_RS00990	COG0784	Response regulator, receiver
VV_RS00990	COG2205	protein histidine kinase activity
VV_RS01050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV_RS01065	COG0346	lactoylglutathione lyase activity
VV_RS01075	COG0371	Dehydrogenase
VV_RS01080	COG5492	domain, Protein
VV_RS01080	COG4932	domain protein
VV_RS01100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VV_RS01115	COG4206	TonB-dependent receptor
VV_RS01125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VV_RS01180	COG3335	DDE superfamily endonuclease
VV_RS01195	COG1322	Protein conserved in bacteria
VV_RS01200	COG2226	methyltransferase
VV_RS01210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VV_RS01215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VV_RS01220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VV_RS01225	COG0805	protein transport
VV_RS01230	COG0084	hydrolase, TatD family'
VV_RS01240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV_RS01240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV_RS01245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VV_RS01260	COG3078	GTPase activator activity
VV_RS01275	COG5001	Diguanylate cyclase
VV_RS01275	COG3300	MHYT domain
VV_RS01285	COG3852	Histidine kinase
VV_RS01295	COG0174	glutamine synthetase
VV_RS01300	COG1217	gtp-binding protein TYPA
VV_RS01315	COG1295	ribonuclease BN
VV_RS01320	COG1490	D-aminoacyl-tRNA deacylase activity
VV_RS01325	COG0456	acetyltransferase
VV_RS01335	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VV_RS01340	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VV_RS01345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VV_RS01350	COG3031	protein transport across the cell outer membrane
VV_RS01360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV_RS01365	COG1459	type II secretion system
VV_RS01370	COG2165	general secretion pathway protein
VV_RS01375	COG2165	general secretion pathway protein
VV_RS01380	COG2165	general secretion pathway protein
VV_RS01385	COG4795	General secretion pathway protein
VV_RS01390	COG3156	type II secretion system protein K
VV_RS01395	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VV_RS01400	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VV_RS01410	COG1218	3'(2'),5'-bisphosphate nucleotidase
VV_RS01415	COG0494	nUDIX hydrolase
VV_RS01420	COG0316	Belongs to the HesB IscA family
VV_RS01420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VV_RS01430	COG0596	Alpha beta hydrolase
VV_RS01440	COG2183	response to ionizing radiation
VV_RS01445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VV_RS01460	COG2233	PERMEase
VV_RS01465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VV_RS01470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV_RS01475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV_RS01480	COG1758	RNA polymerase activity
VV_RS01485	COG0194	GDP metabolic process
VV_RS01500	COG0848	biopolymer transport protein
VV_RS01505	COG0811	peptide transport
VV_RS01510	COG0811	peptide transport
VV_RS01520	COG4206	TonB-dependent receptor
VV_RS01525	COG4174	ABC transporter (Permease)
VV_RS01530	COG4239	(ABC) transporter, permease
VV_RS01535	COG0747	negative chemotaxis
VV_RS01540	COG0444	Belongs to the ABC transporter superfamily
VV_RS01545	COG4608	Belongs to the ABC transporter superfamily
VV_RS01615	COG2856	Zn peptidase
VV_RS01635	COG1561	YicC-like family, N-terminal region
VV_RS01640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VV_RS01645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VV_RS01650	COG1560	Kdo2-lipid A biosynthetic process
VV_RS01655	COG1309	transcriptional regulator
VV_RS01660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VV_RS01670	COG2003	Belongs to the UPF0758 family
VV_RS01675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VV_RS01680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VV_RS01690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VV_RS01700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VV_RS01705	COG0859	PFAM glycosyl transferase family 9
VV_RS01710	COG0463	Glycosyl transferase, family 2
VV_RS01715	COG0859	PFAM glycosyl transferase family 9
VV_RS01720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VV_RS01725	COG3642	lipopolysaccharide core region biosynthetic process
VV_RS01730	COG3083	sulfuric ester hydrolase activity
VV_RS01765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV_RS01785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV_RS01790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VV_RS01795	COG2089	acid synthase
VV_RS01800	COG0110	maltose O-acetyltransferase activity
VV_RS01810	COG0673	inositol 2-dehydrogenase activity
VV_RS01815	COG1083	cytidylyl-transferase
VV_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
VV_RS01845	COG0110	maltose O-acetyltransferase activity
VV_RS01855	COG1519	Transferase
VV_RS01860	COG0859	PFAM glycosyl transferase family 9
VV_RS01865	COG1560	Kdo2-lipid A biosynthetic process
VV_RS01870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VV_RS01875	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV_RS01920	COG1596	polysaccharide export
VV_RS01935	COG3206	protein involved in exopolysaccharide biosynthesis
VV_RS01935	COG0489	protein tyrosine kinase activity
VV_RS01940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VV_RS01945	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VV_RS01980	COG0438	transferase activity, transferring glycosyl groups
VV_RS01985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VV_RS01990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VV_RS01995	COG1051	belongs to the nudix hydrolase family
VV_RS02040	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV_RS02050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV_RS02060	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
VV_RS02070	COG4584	PFAM Integrase catalytic
VV_RS02075	COG1484	DNA-dependent DNA replication
VV_RS02085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VV_RS02100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VV_RS02105	COG0088	Forms part of the polypeptide exit tunnel
VV_RS02110	COG0089	rRNA binding
VV_RS02115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VV_RS02120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VV_RS02130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VV_RS02135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VV_RS02140	COG0255	Belongs to the universal ribosomal protein uL29 family
VV_RS02145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VV_RS02150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VV_RS02155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VV_RS02160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VV_RS02165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VV_RS02170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VV_RS02175	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VV_RS02180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VV_RS02185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VV_RS02190	COG1841	ribosomal large subunit assembly
VV_RS02195	COG0200	Binds to the 23S rRNA
VV_RS02200	COG0201	protein transport
VV_RS02205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VV_RS02210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VV_RS02215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VV_RS02220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VV_RS02225	COG0202	RNA polymerase activity
VV_RS02230	COG0203	ribosomal protein L17
VV_RS02240	COG0545	Peptidyl-prolyl cis-trans isomerase
VV_RS02245	COG3266	domain, Protein
VV_RS02245	COG3061	Opacity-associated protein A
VV_RS02255	COG2153	protein acetylation
VV_RS02265	COG0737	Belongs to the 5'-nucleotidase family
VV_RS02270	COG1648	precorrin-2 dehydrogenase activity
VV_RS02270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VV_RS02275	COG0175	sulfate reduction
VV_RS02280	COG2895	sulfate adenylyltransferase (ATP) activity
VV_RS02285	COG0471	metal ion transport
VV_RS02285	COG3273	potassium ion transport
VV_RS02290	COG0529	Catalyzes the synthesis of activated sulfate
VV_RS02310	COG0577	efflux transmembrane transporter activity
VV_RS02310	COG1136	(ABC) transporter
VV_RS02325	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VV_RS02340	COG0729	surface antigen
VV_RS02345	COG2911	Protein conserved in bacteria
VV_RS02350	COG2105	PFAM AIG2 family protein
VV_RS02360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VV_RS02365	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VV_RS02370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VV_RS02375	COG0163	prenyltransferase activity
VV_RS02380	COG4143	(ABC) transporter
VV_RS02385	COG1178	ABC-type Fe3 transport system permease component
VV_RS02390	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VV_RS02395	COG3028	Belongs to the UPF0307 family
VV_RS02400	COG0312	modulator of DNA gyrase
VV_RS02405	COG2239	Acts as a magnesium transporter
VV_RS02410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV_RS02415	COG1660	Displays ATPase and GTPase activities
VV_RS02420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV_RS02425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VV_RS02435	COG1137	ATPase activity
VV_RS02440	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VV_RS02450	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VV_RS02455	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VV_RS02455	COG0517	IMP dehydrogenase activity
VV_RS02465	COG1127	ABC transporter
VV_RS02470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VV_RS02475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VV_RS02480	COG2854	intermembrane phospholipid transfer
VV_RS02490	COG5007	Belongs to the BolA IbaG family
VV_RS02495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VV_RS02500	COG0204	Acyl-transferase
VV_RS02505	COG0589	response to stress
VV_RS02515	COG2358	TRAP transporter, solute receptor (TAXI family
VV_RS02520	COG1438	arginine binding
VV_RS02525	COG0039	L-malate dehydrogenase activity
VV_RS02535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VV_RS02540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VV_RS02545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VV_RS02550	COG2966	Psort location CytoplasmicMembrane, score
VV_RS02555	COG3610	response to peptide
VV_RS02565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VV_RS02570	COG2967	ApaG domain
VV_RS02575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VV_RS02580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VV_RS02585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VV_RS02590	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VV_RS02595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VV_RS02605	COG0066	3-isopropylmalate dehydratase activity
VV_RS02610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VV_RS02615	COG0473	3-isopropylmalate dehydrogenase activity
VV_RS02620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VV_RS02645	COG1022	Amp-dependent synthetase and ligase
VV_RS02650	COG0028	Belongs to the TPP enzyme family
VV_RS02655	COG0440	acetolactate synthase activity
VV_RS02660	COG3706	GGDEF domain
VV_RS02680	COG1349	DNA-binding transcription factor activity
VV_RS02685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VV_RS02690	COG3722	fumarate hydratase activity
VV_RS02695	COG0246	Mannitol dehydrogenase
VV_RS02700	COG2213	PTS system mannitol-specific
VV_RS02700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV_RS02705	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VV_RS02750	COG0328	RNA-DNA hybrid ribonuclease activity
VV_RS02785	COG2003	Belongs to the UPF0758 family
VV_RS02790	COG1349	DNA-binding transcription factor activity
VV_RS02800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV_RS02805	COG0738	Major facilitator superfamily
VV_RS02815	COG3039	Transposase
VV_RS02840	COG1349	DNA-binding transcription factor activity
VV_RS02845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV_RS02850	COG3715	PTS system
VV_RS02855	COG3716	PTS system mannose fructose sorbose family IID component
VV_RS02860	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV_RS02860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV_RS02865	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
VV_RS02885	COG4584	PFAM Integrase catalytic
VV_RS02900	COG4467	Involved in initiation control of chromosome replication
VV_RS02905	COG1414	Transcriptional regulator
VV_RS02910	COG1028	Short-chain dehydrogenase reductase Sdr
VV_RS02920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV_RS02925	COG0800	Aldolase
VV_RS02945	COG0582	viral genome integration into host DNA
VV_RS02965	COG1610	YqeY-like protein
VV_RS02970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VV_RS02975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VV_RS02980	COG0596	Alpha beta hydrolase
VV_RS02985	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VV_RS02990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VV_RS02995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VV_RS03000	COG1968	undecaprenyl-diphosphatase activity
VV_RS03005	COG0617	tRNA 3'-terminal CCA addition
VV_RS03010	COG3267	Type II secretory pathway component ExeA
VV_RS03010	COG3409	Peptidoglycan-binding domain 1 protein
VV_RS03015	COG4991	sh3 domain protein
VV_RS03020	COG0306	phosphate transporter
VV_RS03025	COG1392	Phosphate transport regulator
VV_RS03030	COG3025	triphosphatase activity
VV_RS03035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VV_RS03045	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VV_RS03050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VV_RS03050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VV_RS03055	COG1538	Outer membrane efflux protein
VV_RS03060	COG0494	nUDIX hydrolase
VV_RS03065	COG3151	Protein conserved in bacteria
VV_RS03075	COG3150	esterase
VV_RS03090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VV_RS03095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VV_RS03100	COG3105	Protein conserved in bacteria
VV_RS03105	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VV_RS03110	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VV_RS03115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VV_RS03120	COG0723	plastoquinol--plastocyanin reductase activity
VV_RS03125	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VV_RS03130	COG2857	Cytochrome c1
VV_RS03135	COG0625	glutathione transferase activity
VV_RS03140	COG2969	positive regulation of protein catabolic process
VV_RS03145	COG2823	Periplasmic or secreted lipoprotein
VV_RS03150	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VV_RS03155	COG0792	nuclease activity
VV_RS03160	COG3107	peptidoglycan biosynthetic process
VV_RS03165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VV_RS03170	COG0275	rRNA processing
VV_RS03175	COG3116	cell division
VV_RS03180	COG0768	penicillin binding
VV_RS03185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VV_RS03190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VV_RS03195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VV_RS03200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VV_RS03205	COG0772	Belongs to the SEDS family
VV_RS03210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VV_RS03215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VV_RS03220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VV_RS03225	COG0849	cell division
VV_RS03230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VV_RS03235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VV_RS03245	COG0653	protein targeting
VV_RS03250	COG0494	nUDIX hydrolase
VV_RS03255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VV_RS03260	COG0505	Belongs to the CarA family
VV_RS03265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VV_RS03280	COG0730	response to heat
VV_RS03285	COG0583	DNA-binding transcription factor activity
VV_RS03290	COG2860	membrane
VV_RS03295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VV_RS03305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VV_RS03315	COG0493	'glutamate synthase
VV_RS03320	COG0070	glutamate synthase
VV_RS03320	COG0067	glutamate synthase
VV_RS03320	COG0069	glutamate synthase activity
VV_RS03330	COG0067	glutamate synthase
VV_RS03330	COG0069	glutamate synthase activity
VV_RS03330	COG0070	glutamate synthase
VV_RS03335	COG1242	4 iron, 4 sulfur cluster binding
VV_RS03340	COG5001	Diguanylate cyclase
VV_RS03340	COG3706	GGDEF domain
VV_RS03340	COG2203	Gaf domain
VV_RS03340	COG4251	negative regulation of phosphorylation
VV_RS03345	COG5002	protein histidine kinase activity
VV_RS03345	COG2198	Histidine kinase
VV_RS03345	COG0784	Response regulator, receiver
VV_RS03355	COG0745	RESPONSE REGULATOR receiver
VV_RS03365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VV_RS03380	COG0083	homoserine kinase activity
VV_RS03385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VV_RS03390	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VV_RS03395	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VV_RS03400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VV_RS03415	COG1115	amino acid carrier protein
VV_RS03420	COG3022	response to hydroperoxide
VV_RS03425	COG0513	Belongs to the DEAD box helicase family
VV_RS03430	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VV_RS03445	COG4974	Belongs to the 'phage' integrase family
VV_RS03450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VV_RS03455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VV_RS03460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VV_RS03465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VV_RS03480	COG0667	Aldo Keto reductase
VV_RS03490	COG3066	DNA modification
VV_RS03495	COG0494	nUDIX hydrolase
VV_RS03505	COG0730	response to heat
VV_RS03510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VV_RS03515	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VV_RS03525	COG1283	sodium-dependent phosphate transmembrane transporter activity
VV_RS03530	COG0583	DNA-binding transcription factor activity
VV_RS03535	COG0640	Transcriptional regulator
VV_RS03540	COG0268	Binds directly to 16S ribosomal RNA
VV_RS03545	COG0728	peptidoglycan biosynthetic process
VV_RS03550	COG0196	riboflavin kinase activity
VV_RS03555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VV_RS03560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VV_RS03565	COG1047	Peptidyl-prolyl cis-trans
VV_RS03570	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VV_RS03580	COG3275	phosphorelay sensor kinase activity
VV_RS03585	COG1966	Carbon starvation protein
VV_RS03605	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VV_RS03620	COG1605	Chorismate mutase
VV_RS03620	COG0287	Prephenate dehydrogenase
VV_RS03625	COG0739	heme binding
VV_RS03635	COG0488	(ABC) transporter
VV_RS03645	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VV_RS03650	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VV_RS03655	COG0077	Prephenate dehydratase
VV_RS03655	COG1605	Chorismate mutase
VV_RS03660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VV_RS03670	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV_RS03685	COG0542	response to heat
VV_RS03735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VV_RS03740	COG0826	peptidase U32
VV_RS03745	COG2974	May be involved in recombination
VV_RS03750	COG0745	RESPONSE REGULATOR receiver
VV_RS03755	COG5002	protein histidine kinase activity
VV_RS03765	COG0248	Ppx GppA phosphatase
VV_RS03770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VV_RS03775	COG0573	inorganic phosphate transmembrane transporter activity
VV_RS03780	COG0581	inorganic phosphate transmembrane transporter activity
VV_RS03785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VV_RS03790	COG0704	Plays a role in the regulation of phosphate uptake
VV_RS03820	COG3142	Participates in the control of copper homeostasis
VV_RS03825	COG0450	alkyl hydroperoxide reductase
VV_RS03830	COG0583	DNA-binding transcription factor activity
VV_RS03835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VV_RS03845	COG0517	IMP dehydrogenase activity
VV_RS03855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VV_RS03860	COG0343	queuine tRNA-ribosyltransferase activity
VV_RS03865	COG1862	Preprotein translocase
VV_RS03870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV_RS03875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV_RS03885	COG0483	inositol monophosphate 1-phosphatase activity
VV_RS03890	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VV_RS03895	COG1959	2 iron, 2 sulfur cluster binding
VV_RS03900	COG1104	cysteine desulfurase activity
VV_RS03905	COG0822	iron-sulfur transferase activity
VV_RS03910	COG0316	Belongs to the HesB IscA family
VV_RS03915	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VV_RS03920	COG0443	Heat shock 70 kDa protein
VV_RS03925	COG0633	Ferredoxin
VV_RS03930	COG2975	iron-sulfur cluster assembly
VV_RS03935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VV_RS03940	COG0105	UTP biosynthetic process
VV_RS03945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VV_RS03955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VV_RS03960	COG0124	histidyl-tRNA synthetase
VV_RS03965	COG2976	Protein conserved in bacteria
VV_RS03970	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV_RS03975	COG1160	GTP binding
VV_RS03985	COG2199	diguanylate cyclase activity
VV_RS03985	COG2203	Gaf domain
VV_RS03995	COG1570	exodeoxyribonuclease VII activity
VV_RS04000	COG0516	GMP reductase activity
VV_RS04000	COG0517	IMP dehydrogenase activity
VV_RS04005	COG0519	Catalyzes the synthesis of GMP from XMP
VV_RS04005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VV_RS04015	COG1584	GPR1 FUN34 yaaH family protein
VV_RS04020	COG1115	amino acid carrier protein
VV_RS04025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV_RS04030	COG0583	DNA-binding transcription factor activity
VV_RS04050	COG0009	L-threonylcarbamoyladenylate synthase
VV_RS04130	COG0328	RNA-DNA hybrid ribonuclease activity
VV_RS04145	COG2003	Belongs to the UPF0758 family
VV_RS04160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VV_RS04180	COG0582	viral genome integration into host DNA
VV_RS04185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VV_RS04190	COG2867	negative regulation of translational initiation
VV_RS04195	COG2914	Belongs to the UPF0125 (RnfH) family
VV_RS04200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV_RS04210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VV_RS04215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VV_RS04245	COG0443	Heat shock 70 kDa protein
VV_RS04250	COG0484	heat shock protein binding
VV_RS04280	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VV_RS04285	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VV_RS04290	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VV_RS04295	COG0583	DNA-binding transcription factor activity
VV_RS04305	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VV_RS04310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VV_RS04310	COG0047	phosphoribosylformylglycinamidine synthase activity
VV_RS04335	COG2195	Cleaves the N-terminal amino acid of tripeptides
VV_RS04345	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VV_RS04350	COG1073	alpha beta
VV_RS04360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VV_RS04365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VV_RS04370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VV_RS04375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VV_RS04375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VV_RS04390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VV_RS04395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VV_RS04400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VV_RS04405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VV_RS04410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VV_RS04415	COG0142	geranyltranstransferase activity
VV_RS04420	COG1722	exodeoxyribonuclease VII activity
VV_RS04425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VV_RS04435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV_RS04435	COG0301	tRNA thio-modification
VV_RS04440	COG0583	DNA-binding transcription factor activity
VV_RS04450	COG2363	Small membrane protein
VV_RS04465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV_RS04470	COG1611	Belongs to the LOG family
VV_RS04485	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VV_RS04485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VV_RS04495	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VV_RS04500	COG1464	Belongs to the NlpA lipoprotein family
VV_RS04505	COG2011	ABC-type metal ion transport system permease component
VV_RS04510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VV_RS04515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VV_RS04525	COG1263	PTS System
VV_RS04525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV_RS04530	COG0366	Alpha amylase catalytic
VV_RS04540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VV_RS04550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VV_RS04555	COG0321	lipoyl(octanoyl) transferase activity
VV_RS04560	COG2921	Belongs to the UPF0250 family
VV_RS04565	COG1686	Belongs to the peptidase S11 family
VV_RS04570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VV_RS04575	COG0772	Belongs to the SEDS family
VV_RS04580	COG0768	penicillin binding
VV_RS04585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VV_RS04590	COG0799	negative regulation of ribosome biogenesis
VV_RS04595	COG1466	dna polymerase III delta subunit
VV_RS04600	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VV_RS04605	COG0495	leucyl-tRNA aminoacylation
VV_RS04610	COG2888	peptidyl-tyrosine sulfation
VV_RS04615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VV_RS04620	COG4535	Mg2 and Co2 transporter CorC
VV_RS04625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VV_RS04630	COG1702	phosphate starvation-inducible protein PhoH
VV_RS04635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VV_RS04640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV_RS04725	COG0193	aminoacyl-tRNA hydrolase activity
VV_RS04730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VV_RS04735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VV_RS04740	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VV_RS04745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VV_RS04750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VV_RS04755	COG2890	protein-(glutamine-N5) methyltransferase activity
VV_RS04765	COG2912	Transglutaminase-like superfamily
VV_RS04770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VV_RS04780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VV_RS04785	COG1187	pseudouridine synthase activity
VV_RS04790	COG2840	Smr protein MutS2
VV_RS04805	COG3735	TraB family
VV_RS04820	COG2608	mercury ion transmembrane transporter activity
VV_RS04820	COG2217	Heavy metal translocating P-type atpase
VV_RS04835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV_RS04880	COG0784	Response regulator, receiver
VV_RS04880	COG0835	chemotaxis
VV_RS04885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VV_RS04890	COG1815	bacterial-type flagellum-dependent cell motility
VV_RS04905	COG1749	Flagellar hook protein flgE
VV_RS04910	COG4787	bacterial-type flagellum-dependent cell motility
VV_RS04920	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VV_RS04925	COG1706	bacterial-type flagellum-dependent cell motility
VV_RS04930	COG3951	Flagellar rod assembly protein muramidase FlgJ
VV_RS04930	COG1705	Flagellar rod assembly protein muramidase FlgJ
VV_RS04940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV_RS04945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV_RS04955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV_RS04960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV_RS04965	COG2190	(PTS) system
VV_RS04970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VV_RS04975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VV_RS04980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VV_RS04985	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VV_RS04990	COG3115	cell septum assembly
VV_RS04995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VV_RS05015	COG0330	HflC and HflK could
VV_RS05020	COG3118	belongs to the thioredoxin family
VV_RS05025	COG0300	oxidoreductase activity
VV_RS05030	COG1090	epimerase
VV_RS05055	COG0622	Phosphoesterase
VV_RS05075	COG3710	Transcriptional regulator
VV_RS05080	COG0326	Molecular chaperone. Has ATPase activity
VV_RS05085	COG0563	adenylate kinase activity
VV_RS05090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VV_RS05095	COG0840	transmembrane signaling receptor activity
VV_RS05100	COG3104	oligopeptide transport
VV_RS05110	COG0367	asparagine synthase
VV_RS05115	COG4651	solute:proton antiporter activity
VV_RS05115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VV_RS05120	COG1846	Transcriptional regulator
VV_RS05120	COG1940	carbohydrate kinase activity
VV_RS05125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VV_RS05130	COG1263	PTS System
VV_RS05130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV_RS05130	COG2190	(PTS) system
VV_RS05135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV_RS05150	COG0716	FMN binding
VV_RS05160	COG0596	Alpha beta hydrolase
VV_RS05165	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VV_RS05170	COG0033	Phosphoglucomutase
VV_RS05175	COG2964	Protein conserved in bacteria
VV_RS05180	COG0251	oxidation-reduction process
VV_RS05190	COG0446	pyridine nucleotide-disulphide oxidoreductase
VV_RS05200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VV_RS05210	COG2009	succinate dehydrogenase
VV_RS05215	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VV_RS05220	COG1053	succinate dehydrogenase
VV_RS05230	COG0567	Dehydrogenase, E1 component
VV_RS05235	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV_RS05240	COG0045	succinate-CoA ligase (ADP-forming) activity
VV_RS05250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VV_RS05255	COG1121	(ABC) transporter
VV_RS05260	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VV_RS05270	COG1918	ferrous iron import across plasma membrane
VV_RS05290	COG0018	arginyl-trna synthetase
VV_RS05295	COG3102	Protein conserved in bacteria
VV_RS05300	COG0788	formyltetrahydrofolate deformylase activity
VV_RS05310	COG1199	ATP-dependent helicase activity
VV_RS05315	COG1214	PFAM Peptidase M22, glycoprotease
VV_RS05330	COG0596	Alpha beta hydrolase
VV_RS05335	COG0318	PFAM AMP-dependent synthetase and ligase
VV_RS05340	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VV_RS05345	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VV_RS05350	COG2894	cell division
VV_RS05355	COG0850	regulation of cytokinetic process
VV_RS05360	COG3100	YcgL domain-containing protein
VV_RS05365	COG2951	lytic endotransglycosylase activity
VV_RS05375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VV_RS05385	COG0745	RESPONSE REGULATOR receiver
VV_RS05390	COG5002	protein histidine kinase activity
VV_RS05405	COG1028	Short-chain dehydrogenase reductase Sdr
VV_RS05415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VV_RS05440	COG2986	histidine ammonia-lyase
VV_RS05445	COG1216	Glycosyl transferase, family 2
VV_RS05455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VV_RS05465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV_RS05470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV_RS05515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VV_RS05535	COG1175	transmembrane transport
VV_RS05545	COG3842	ATPase activity
VV_RS05550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VV_RS05555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VV_RS05560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VV_RS05570	COG2204	response regulator
VV_RS05575	COG4191	Histidine kinase
VV_RS05580	COG0544	peptidyl-prolyl cis-trans isomerase activity
VV_RS05590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VV_RS05595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VV_RS05600	COG0776	regulation of translation
VV_RS05605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VV_RS05610	COG1555	photosystem II stabilization
VV_RS05625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VV_RS05630	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VV_RS05635	COG0436	Aminotransferase
VV_RS05640	COG1169	isochorismate synthase
VV_RS05645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VV_RS05655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VV_RS05665	COG0318	PFAM AMP-dependent synthetase and ligase
VV_RS05675	COG2855	membrane
VV_RS05700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV_RS05705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV_RS05720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VV_RS05725	COG1522	sequence-specific DNA binding
VV_RS05735	COG1946	Acyl-CoA thioesterase
VV_RS05740	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VV_RS05785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VV_RS05790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VV_RS05800	COG3139	Protein of unknown function (DUF1315)
VV_RS05805	COG0252	asparaginase activity
VV_RS05810	COG0616	signal peptide processing
VV_RS05815	COG0446	pyridine nucleotide-disulphide oxidoreductase
VV_RS05815	COG1902	pentaerythritol trinitrate reductase activity
VV_RS05820	COG0778	Nitroreductase
VV_RS05825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VV_RS05830	COG0123	including yeast histone deacetylase and acetoin utilization protein
VV_RS05835	COG0784	Response regulator, receiver
VV_RS05835	COG2205	protein histidine kinase activity
VV_RS05845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VV_RS05850	COG2731	YhcH YjgK YiaL family protein
VV_RS05855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV_RS05860	COG0569	domain protein
VV_RS05870	COG3083	sulfuric ester hydrolase activity
VV_RS05875	COG3082	Protein of unknown function (DUF1414)
VV_RS05880	COG3081	Nucleoid-associated protein
VV_RS05895	COG1757	Na H antiporter
VV_RS05900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VV_RS05910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV_RS05915	COG2095	MarC family integral membrane protein
VV_RS05920	COG1012	belongs to the aldehyde dehydrogenase family
VV_RS05920	COG1454	alcohol dehydrogenase
VV_RS05925	COG1028	Short-chain dehydrogenase reductase Sdr
VV_RS05940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VV_RS05950	COG2056	Na+-H+ antiporter family
VV_RS05955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VV_RS05960	COG2885	chlorophyll binding
VV_RS05970	COG0346	lactoylglutathione lyase activity
VV_RS05975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VV_RS05980	COG4660	Part of a membrane complex involved in electron transport
VV_RS05985	COG4659	FMN binding
VV_RS05990	COG4658	electron transport chain
VV_RS05995	COG4656	Part of a membrane complex involved in electron transport
VV_RS06000	COG2878	Part of a membrane complex involved in electron transport
VV_RS06005	COG4657	Part of a membrane complex involved in electron transport
VV_RS06020	COG0556	nucleotide-excision repair
VV_RS06025	COG2204	response regulator
VV_RS06030	COG2198	Histidine kinase
VV_RS06035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VV_RS06040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VV_RS06045	COG0521	Mo-molybdopterin cofactor biosynthetic process
VV_RS06050	COG0315	cyclic pyranopterin monophosphate synthase activity
VV_RS06055	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VV_RS06060	COG0314	molybdopterin synthase activity
VV_RS06070	COG0601	transmembrane transport
VV_RS06075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV_RS06080	COG0444	Belongs to the ABC transporter superfamily
VV_RS06090	COG0435	Glutathione S-transferase
VV_RS06100	COG2350	Protein conserved in bacteria
VV_RS06120	COG1301	dicarboxylic acid transport
VV_RS06125	COG0159	tryptophan synthase activity
VV_RS06130	COG0133	tryptophan synthase activity
VV_RS06135	COG0135	phosphoribosylanthranilate isomerase activity
VV_RS06135	COG0134	indole-3-glycerol-phosphate synthase activity
VV_RS06140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VV_RS06145	COG0512	Glutamine amidotransferase of anthranilate synthase
VV_RS06150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VV_RS06160	COG0613	PHP domain protein
VV_RS06165	COG0009	L-threonylcarbamoyladenylate synthase
VV_RS06180	COG3099	Belongs to the UPF0263 family
VV_RS06185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VV_RS06195	COG5001	Diguanylate cyclase
VV_RS06200	COG0417	DNA replication proofreading
VV_RS06205	COG2197	response regulator
VV_RS06210	COG0322	excinuclease ABC activity
VV_RS06275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV_RS06280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV_RS06285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VV_RS06310	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VV_RS06315	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VV_RS06320	COG0437	4 iron, 4 sulfur cluster binding
VV_RS06325	COG3301	Polysulphide reductase, NrfD
VV_RS06330	COG1138	Cytochrome C-type biogenesis protein
VV_RS06340	COG3088	subunit of a heme lyase
VV_RS06340	COG4235	cytochrome complex assembly
VV_RS06355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV_RS06355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV_RS06360	COG0489	protein tyrosine kinase activity
VV_RS06365	COG0572	uridine kinase
VV_RS06375	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VV_RS06380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VV_RS06385	COG0659	secondary active sulfate transmembrane transporter activity
VV_RS06390	COG1530	ribonuclease E activity
VV_RS06400	COG0424	maF-like protein
VV_RS06405	COG1399	metal-binding, possibly nucleic acid-binding protein
VV_RS06410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VV_RS06415	COG0416	fatty acid biosynthetic process
VV_RS06420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VV_RS06435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV_RS06450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VV_RS06455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VV_RS06465	COG0084	hydrolase, TatD family'
VV_RS06470	COG1263	PTS System
VV_RS06470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV_RS06480	COG0733	neurotransmitter:sodium symporter activity
VV_RS06490	COG4667	esterase of the alpha-beta hydrolase superfamily
VV_RS06495	COG0469	pyruvate kinase activity
VV_RS06500	COG1940	carbohydrate kinase activity
VV_RS06505	COG0835	chemotaxis
VV_RS06505	COG0784	Response regulator, receiver
VV_RS06510	COG0587	DNA-directed DNA polymerase activity
VV_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
VV_RS06530	COG0616	signal peptide processing
VV_RS06535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VV_RS06540	COG0539	negative regulation of cytoplasmic translation
VV_RS06545	COG0776	regulation of translation
VV_RS06550	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VV_RS06555	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VV_RS06560	COG0284	orotidine-5'-phosphate decarboxylase activity
VV_RS06565	COG4174	ABC transporter (Permease)
VV_RS06570	COG4239	(ABC) transporter, permease
VV_RS06575	COG4166	transmembrane transport
VV_RS06580	COG0444	Belongs to the ABC transporter superfamily
VV_RS06585	COG4608	Belongs to the ABC transporter superfamily
VV_RS06620	COG0583	DNA-binding transcription factor activity
VV_RS06630	COG0686	Belongs to the AlaDH PNT family
VV_RS06645	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VV_RS06650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VV_RS06655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VV_RS06665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VV_RS06670	COG0156	8-amino-7-oxononanoate synthase activity
VV_RS06680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VV_RS06685	COG0501	Belongs to the peptidase M48B family
VV_RS06695	COG0300	oxidoreductase activity
VV_RS06710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VV_RS06730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VV_RS06735	COG2915	High frequency lysogenization protein hflD homolog
VV_RS06740	COG0482	sulfurtransferase activity
VV_RS06750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV_RS06755	COG2916	Histone family protein nucleoid-structuring protein H-NS
VV_RS06760	COG1757	Na H antiporter
VV_RS06765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VV_RS06770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VV_RS06775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VV_RS06780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VV_RS06780	COG0131	Imidazoleglycerol-phosphate dehydratase
VV_RS06785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VV_RS06790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VV_RS06795	COG0107	imidazoleglycerol-phosphate synthase activity
VV_RS06800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VV_RS06800	COG0140	phosphoribosyl-ATP diphosphatase activity
VV_RS06805	COG3012	SEC-C Motif Domain Protein
VV_RS06810	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VV_RS06815	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV_RS06820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VV_RS06825	COG0215	cysteine-tRNA ligase activity
VV_RS06830	COG1435	thymidine kinase activity
VV_RS06840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VV_RS06845	COG0583	DNA-binding transcription factor activity
VV_RS06865	COG2116	formate transmembrane transporter activity
VV_RS06870	COG0390	transport system, permease component
VV_RS06875	COG4459	periplasmic nitrate reductase
VV_RS06880	COG3005	denitrification pathway
VV_RS06885	COG0243	molybdopterin cofactor binding
VV_RS06915	COG1227	inorganic diphosphatase activity
VV_RS06930	COG4172	Belongs to the ABC transporter superfamily
VV_RS06955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VV_RS06960	COG1842	Phage shock protein A
VV_RS06970	COG1983	PspC domain protein
VV_RS06990	COG2818	Glycosylase
VV_RS06995	COG0626	cystathionine gamma-synthase activity
VV_RS07005	COG0733	neurotransmitter:sodium symporter activity
VV_RS07015	COG0564	pseudouridine synthase activity
VV_RS07025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VV_RS07030	COG1151	hydroxylamine reductase activity
VV_RS07035	COG3604	Transcriptional regulator
VV_RS07040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VV_RS07045	COG4136	ATPase activity
VV_RS07050	COG4135	transport system, permease component
VV_RS07055	COG4134	Bacterial extracellular solute-binding protein
VV_RS07065	COG3313	Fe-S protein
VV_RS07090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VV_RS07095	COG2205	protein histidine kinase activity
VV_RS07110	COG1061	Type III restriction enzyme res subunit
VV_RS07120	COG2814	Major facilitator Superfamily
VV_RS07135	COG0702	epimerase
VV_RS07140	COG1136	(ABC) transporter
VV_RS07155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VV_RS07170	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VV_RS07175	COG2985	domain, Protein
VV_RS07175	COG3273	potassium ion transport
VV_RS07180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VV_RS07185	COG1979	alcohol dehydrogenase
VV_RS07190	COG1737	Transcriptional regulator
VV_RS07195	COG0076	glutamate decarboxylase activity
VV_RS07205	COG2431	L-lysine efflux transmembrane transporter activity
VV_RS07215	COG3070	regulator of competence-specific genes
VV_RS07230	COG5002	protein histidine kinase activity
VV_RS07230	COG5002	protein histidine kinase activity
VV_RS07240	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VV_RS07245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VV_RS07250	COG4988	ABC transporter
VV_RS07255	COG0492	ferredoxin-NADP+ reductase activity
VV_RS07280	COG0471	metal ion transport
VV_RS07285	COG2949	membrane
VV_RS07290	COG0281	malic enzyme
VV_RS07295	COG1643	Atp-dependent helicase
VV_RS07310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VV_RS07320	COG1346	cytolysis
VV_RS07325	COG1380	Effector of murein hydrolase LrgA
VV_RS07330	COG2925	Exonuclease
VV_RS07340	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VV_RS07345	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VV_RS07365	COG2988	succinylglutamate desuccinylase activity
VV_RS07370	COG4139	cobalamin transport
VV_RS07375	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VV_RS07405	COG1451	nucleotide metabolic process
VV_RS07410	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VV_RS07420	COG3063	Type IV pilus biogenesis stability protein PilW
VV_RS07425	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VV_RS07430	COG2195	Cleaves the N-terminal amino acid of tripeptides
VV_RS07440	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VV_RS07450	COG0625	glutathione transferase activity
VV_RS07490	COG1278	Cold shock
VV_RS07500	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VV_RS07505	COG0584	glycerophosphoryl diester phosphodiesterase
VV_RS07510	COG1349	DNA-binding transcription factor activity
VV_RS07515	COG3842	ATPase activity
VV_RS07520	COG0395	ABC-type sugar transport system, permease component
VV_RS07525	COG1175	transmembrane transport
VV_RS07530	COG1653	transport
VV_RS07545	COG0730	response to heat
VV_RS07555	COG2197	response regulator
VV_RS07595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VV_RS07605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VV_RS07610	COG0372	Belongs to the citrate synthase family
VV_RS07620	COG2828	Protein conserved in bacteria
VV_RS07650	COG0561	phosphatase activity
VV_RS07655	COG0602	queuosine metabolic process
VV_RS07660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VV_RS07665	COG3706	GGDEF domain
VV_RS07690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VV_RS07700	COG1254	Belongs to the acylphosphatase family
VV_RS07705	COG2920	part of a sulfur-relay system
VV_RS07715	COG0670	Belongs to the BI1 family
VV_RS07720	COG1126	abc transporter atp-binding protein
VV_RS07725	COG0765	amino acid transport
VV_RS07730	COG4597	amino acid ABC transporter
VV_RS07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV_RS07745	COG0437	4 iron, 4 sulfur cluster binding
VV_RS07750	COG0348	domain, Protein
VV_RS07755	COG0204	Acyl-transferase
VV_RS07820	COG1846	Transcriptional regulator
VV_RS07840	COG3971	2-oxopent-4-enoate hydratase activity
VV_RS07875	COG3384	dioxygenase
VV_RS07880	COG1012	belongs to the aldehyde dehydrogenase family
VV_RS07890	COG1960	acyl-CoA dehydrogenase activity
VV_RS07895	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VV_RS07910	COG1115	amino acid carrier protein
VV_RS07940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VV_RS07955	COG3290	protein histidine kinase activity
VV_RS07960	COG4565	transcriptional regulatory protein
VV_RS07965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VV_RS07970	COG0363	glucosamine-6-phosphate deaminase activity
VV_RS07975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VV_RS08005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV_RS08015	COG0438	transferase activity, transferring glycosyl groups
VV_RS08060	COG2204	response regulator
VV_RS08090	COG1366	Belongs to the anti-sigma-factor antagonist family
VV_RS08095	COG1793	dna ligase
VV_RS08100	COG3706	GGDEF domain
VV_RS08105	COG1666	GTP binding
VV_RS08110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VV_RS08125	COG2996	Protein conserved in bacteria
VV_RS08130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VV_RS08130	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VV_RS08135	COG3008	intermembrane lipid transfer
VV_RS08140	COG2995	paraquat-inducible protein a
VV_RS08145	COG1132	(ABC) transporter
VV_RS08150	COG1956	GAF domain-containing protein
VV_RS08155	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VV_RS08170	COG0308	aminopeptidase N
VV_RS08175	COG2902	Dehydrogenase
VV_RS08180	COG0167	dihydroorotate dehydrogenase activity
VV_RS08190	COG0116	Belongs to the methyltransferase superfamily
VV_RS08190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VV_RS08200	COG0488	(ABC) transporter
VV_RS08215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VV_RS08220	COG1067	ATP-dependent peptidase activity
VV_RS08225	COG3120	sequence-specific DNA binding
VV_RS08245	COG0784	Response regulator, receiver
VV_RS08245	COG2205	protein histidine kinase activity
VV_RS08260	COG3278	Belongs to the heme-copper respiratory oxidase family
VV_RS08275	COG2010	Cytochrome c
VV_RS08285	COG2217	Heavy metal translocating P-type atpase
VV_RS08300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV_RS08305	COG0589	response to stress
VV_RS08310	COG0037	tRNA processing
VV_RS08320	COG2992	FlgJ-related protein
VV_RS08330	COG3842	ATPase activity
VV_RS08335	COG1176	ABC-type spermidine putrescine transport system, permease component I
VV_RS08340	COG1177	transmembrane transport
VV_RS08350	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VV_RS08355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VV_RS08360	COG0004	ammonium transporteR
VV_RS08390	COG0437	4 iron, 4 sulfur cluster binding
VV_RS08395	COG0243	molybdopterin cofactor binding
VV_RS08395	COG3383	formate dehydrogenase (NAD+) activity
VV_RS08425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VV_RS08435	COG0488	(ABC) transporter
VV_RS08450	COG3852	Histidine kinase
VV_RS08455	COG2204	response regulator
VV_RS08465	COG4662	Binding-protein-dependent transport system inner membrane component
VV_RS08470	COG3842	ATPase activity
VV_RS08475	COG0746	molybdenum cofactor guanylyltransferase activity
VV_RS08490	COG1940	carbohydrate kinase activity
VV_RS08495	COG3148	PFAM DTW domain containing protein
VV_RS08505	COG0840	transmembrane signaling receptor activity
VV_RS08510	COG0791	NLP P60 protein
VV_RS08520	COG3706	GGDEF domain
VV_RS08540	COG0307	riboflavin synthase, alpha
VV_RS08545	COG0534	Mate efflux family protein
VV_RS08570	COG2801	Transposase and inactivated derivatives
VV_RS08610	COG2801	Transposase and inactivated derivatives
VV_RS08740	COG0582	viral genome integration into host DNA
VV_RS08770	COG2801	Transposase and inactivated derivatives
VV_RS08785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV_RS08790	COG4115	mRNA cleavage
VV_RS08795	COG2161	toxin-antitoxin pair type II binding
VV_RS08930	COG2801	Transposase and inactivated derivatives
VV_RS08955	COG2801	Transposase and inactivated derivatives
VV_RS08960	COG2801	Transposase and inactivated derivatives
VV_RS09005	COG0625	glutathione transferase activity
VV_RS09060	COG2801	Transposase and inactivated derivatives
VV_RS09130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV_RS09155	COG0454	-acetyltransferase
VV_RS09190	COG0454	-acetyltransferase
VV_RS09305	COG4628	conserved protein (DUF2132)
VV_RS09335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VV_RS09345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VV_RS09355	COG4326	sporulation control protein
VV_RS09365	COG1228	amidohydrolase
VV_RS09370	COG0010	Belongs to the arginase family
VV_RS09375	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VV_RS09380	COG2986	histidine ammonia-lyase
VV_RS09390	COG5640	endopeptidase activity
VV_RS09395	COG2020	methyltransferase activity
VV_RS09400	COG0277	FAD linked oxidase domain protein
VV_RS09400	COG0247	lactate metabolic process
VV_RS09415	COG2885	chlorophyll binding
VV_RS09430	COG0295	cytidine deaminase activity
VV_RS09435	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VV_RS09440	COG0500	methyltransferase
VV_RS09450	COG0776	regulation of translation
VV_RS09465	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VV_RS09470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV_RS09470	COG0072	phenylalanine-tRNA ligase activity
VV_RS09475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VV_RS09550	COG1166	arginine decarboxylase activity
VV_RS09555	COG0010	Belongs to the arginase family
VV_RS09560	COG2814	Major facilitator Superfamily
VV_RS09565	COG5380	lipid catabolic process
VV_RS09570	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VV_RS09595	COG1643	Atp-dependent helicase
VV_RS09605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VV_RS09645	COG2894	cell division
VV_RS09655	COG4964	Belongs to the GSP D family
VV_RS09685	COG3713	MltA-interacting MipA family protein
VV_RS09710	COG3706	GGDEF domain
VV_RS09720	COG0443	Heat shock 70 kDa protein
VV_RS09725	COG0443	Heat shock 70 kDa protein
VV_RS09750	COG2165	general secretion pathway protein
VV_RS09765	COG0438	transferase activity, transferring glycosyl groups
VV_RS09765	COG0297	glycogen (starch) synthase activity
VV_RS09770	COG0438	transferase activity, transferring glycosyl groups
VV_RS09795	COG1596	polysaccharide export
VV_RS09810	COG1115	amino acid carrier protein
VV_RS09815	COG1132	(ABC) transporter
VV_RS09820	COG1132	(ABC) transporter
VV_RS09835	COG0783	Belongs to the Dps family
VV_RS09850	COG0814	amino acid
VV_RS09855	COG1597	lipid kinase activity
VV_RS09865	COG4667	esterase of the alpha-beta hydrolase superfamily
VV_RS09870	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VV_RS09885	COG0583	DNA-binding transcription factor activity
VV_RS09890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VV_RS09895	COG1328	CTP reductase activity
VV_RS09900	COG5001	Diguanylate cyclase
VV_RS09900	COG3300	MHYT domain
VV_RS09915	COG2200	EAL domain
VV_RS09915	COG2199	diguanylate cyclase activity
VV_RS09920	COG3706	GGDEF domain
VV_RS09930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV_RS09930	COG4191	Histidine kinase
VV_RS09935	COG0471	metal ion transport
VV_RS09950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV_RS09955	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VV_RS09960	COG3768	UPF0283 membrane protein
VV_RS09965	COG3106	COG3106 Predicted ATPase
VV_RS09980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VV_RS09985	COG2205	protein histidine kinase activity
VV_RS09985	COG0784	Response regulator, receiver
VV_RS09995	COG0494	nUDIX hydrolase
VV_RS10000	COG0814	amino acid
VV_RS10005	COG1760	l-serine dehydratase
VV_RS10010	COG2200	EAL domain
VV_RS10020	COG0720	synthase
VV_RS10025	COG0840	transmembrane signaling receptor activity
VV_RS10030	COG0017	Asparaginyl-tRNA synthetase
VV_RS10040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV_RS10055	COG2770	Histidine kinase
VV_RS10055	COG3437	response regulator, receiver
VV_RS10060	COG1448	Aminotransferase
VV_RS10080	COG0840	transmembrane signaling receptor activity
VV_RS10085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VV_RS10090	COG1846	Transcriptional regulator
VV_RS10115	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VV_RS10135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV_RS10140	COG3108	Peptidase M15
VV_RS10145	COG2989	Protein conserved in bacteria
VV_RS10175	COG2186	Transcriptional regulator
VV_RS10180	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VV_RS10190	COG3318	Belongs to the UPF0149 family
VV_RS10190	COG3012	SEC-C Motif Domain Protein
VV_RS10205	COG0366	Alpha amylase catalytic
VV_RS10215	COG4120	Belongs to the binding-protein-dependent transport system permease family
VV_RS10225	COG3092	negative regulation of chromosome organization
VV_RS10230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VV_RS10235	COG0280	phosphate acetyltransferase
VV_RS10235	COG0857	belongs to the CobB CobQ family
VV_RS10240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VV_RS10245	COG0583	DNA-binding transcription factor activity
VV_RS10270	COG1032	radical SAM domain protein
VV_RS10290	COG2207	Transcriptional regulator
VV_RS10330	COG0488	(ABC) transporter
VV_RS10385	COG0861	Integral membrane protein TerC family
VV_RS10390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV_RS10395	COG1454	alcohol dehydrogenase
VV_RS10400	COG0235	Class ii aldolase
VV_RS10405	COG4154	Belongs to the RbsD FucU family
VV_RS10410	COG1070	Carbohydrate kinase
VV_RS10415	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
VV_RS10420	COG0738	Major facilitator superfamily
VV_RS10425	COG1349	DNA-binding transcription factor activity
VV_RS10430	COG0840	transmembrane signaling receptor activity
VV_RS10435	COG0546	phosphoglycolate phosphatase activity
VV_RS10450	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VV_RS10470	COG2801	Transposase and inactivated derivatives
VV_RS10515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VV_RS10525	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VV_RS10545	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VV_RS10555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VV_RS10720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VV_RS10725	COG3069	C4-dicarboxylate transmembrane transporter activity
VV_RS10745	COG1737	Transcriptional regulator
VV_RS10755	COG2003	Belongs to the UPF0758 family
VV_RS10770	COG0328	RNA-DNA hybrid ribonuclease activity
VV_RS10810	COG0582	viral genome integration into host DNA
VV_RS10825	COG0784	Response regulator, receiver
VV_RS10825	COG2205	protein histidine kinase activity
VV_RS10835	COG0754	glutathionylspermidine amidase activity
VV_RS10845	COG3766	membrane
VV_RS10855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VV_RS10860	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VV_RS10865	COG2885	chlorophyll binding
VV_RS10870	COG0823	Involved in the tonB-independent uptake of proteins
VV_RS10885	COG0811	peptide transport
VV_RS10890	COG0824	Thioesterase
VV_RS10905	COG1294	oxidase, subunit
VV_RS10910	COG1271	oxidase subunit
VV_RS10915	COG2255	four-way junction helicase activity
VV_RS10920	COG0632	four-way junction helicase activity
VV_RS10925	COG0840	transmembrane signaling receptor activity
VV_RS10930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VV_RS10935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VV_RS10945	COG4106	trans-aconitate 2-methyltransferase activity
VV_RS10950	COG0500	methyltransferase
VV_RS10955	COG4067	protein conserved in archaea
VV_RS10955	COG0189	ligase activity
VV_RS10985	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VV_RS10990	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VV_RS10995	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VV_RS11000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VV_RS11005	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VV_RS11010	COG0745	RESPONSE REGULATOR receiver
VV_RS11015	COG3381	protein complex oligomerization
VV_RS11020	COG1609	Transcriptional regulator
VV_RS11025	COG3070	regulator of competence-specific genes
VV_RS11045	COG0297	glycogen (starch) synthase activity
VV_RS11050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VV_RS11055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VV_RS11070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VV_RS11085	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VV_RS11090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VV_RS11095	COG0542	response to heat
VV_RS11100	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VV_RS11105	COG1278	Cold shock
VV_RS11125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VV_RS11130	COG1199	ATP-dependent helicase activity
VV_RS11140	COG3923	Primosomal replication protein n
VV_RS11150	COG0840	transmembrane signaling receptor activity
VV_RS11155	COG0708	Exodeoxyribonuclease III
VV_RS11195	COG1882	Formate acetyltransferase
VV_RS11210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VV_RS11220	COG3013	Belongs to the UPF0304 family
VV_RS11225	COG2766	serine protein kinase
VV_RS11230	COG2718	Belongs to the UPF0229 family
VV_RS11235	COG2719	SpoVR family
VV_RS11240	COG2199	diguanylate cyclase activity
VV_RS11245	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VV_RS11250	COG2835	tetraacyldisaccharide 4'-kinase activity
VV_RS11255	COG1663	tetraacyldisaccharide 4'-kinase activity
VV_RS11260	COG1132	(ABC) transporter
VV_RS11265	COG2333	competence protein COMEC
VV_RS11265	COG0658	competence protein
VV_RS11275	COG4591	ABC-type transport system involved in lipoprotein release permease component
VV_RS11280	COG1136	(ABC) transporter
VV_RS11285	COG4591	ABC-type transport system involved in lipoprotein release permease component
VV_RS11295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VV_RS11310	COG1252	NADH dehydrogenase
VV_RS11340	COG0537	adenosine 5'-monophosphoramidase activity
VV_RS11365	COG0617	tRNA 3'-terminal CCA addition
VV_RS11365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VV_RS11365	COG0517	IMP dehydrogenase activity
VV_RS11370	COG3706	GGDEF domain
VV_RS11375	COG1982	Orn Lys Arg decarboxylase major
VV_RS11380	COG0531	amino acid
VV_RS11385	COG3710	Transcriptional regulator
VV_RS11405	COG2199	diguanylate cyclase activity
VV_RS11405	COG2203	Gaf domain
VV_RS11410	COG2239	Acts as a magnesium transporter
VV_RS11420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VV_RS11425	COG2226	methyltransferase
VV_RS11440	COG1785	Belongs to the alkaline phosphatase family
VV_RS11450	COG0346	lactoylglutathione lyase activity
VV_RS11460	COG2983	Belongs to the UPF0260 family
VV_RS11470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VV_RS11475	COG0745	RESPONSE REGULATOR receiver
VV_RS11480	COG2205	protein histidine kinase activity
VV_RS11495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VV_RS11500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VV_RS11510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VV_RS11520	COG0745	RESPONSE REGULATOR receiver
VV_RS11525	COG0583	DNA-binding transcription factor activity
VV_RS11530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VV_RS11535	COG1286	toxin biosynthetic process
VV_RS11540	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VV_RS11545	COG0285	dihydrofolate synthase activity
VV_RS11550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VV_RS11555	COG0101	tRNA pseudouridine synthase activity
VV_RS11565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VV_RS11570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VV_RS11575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VV_RS11580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV_RS11580	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VV_RS11590	COG3101	peptidyl-lysine hydroxylation
VV_RS11595	COG2860	membrane
VV_RS11600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VV_RS11605	COG2890	protein-(glutamine-N5) methyltransferase activity
VV_RS11610	COG2840	Smr protein MutS2
VV_RS11615	COG2062	phosphohistidine phosphatase, SixA
VV_RS11620	COG1025	Belongs to the peptidase M16 family
VV_RS11625	COG1024	Enoyl-CoA hydratase
VV_RS11625	COG1250	3-hydroxyacyl-CoA dehydrogenase
VV_RS11630	COG0183	Belongs to the thiolase family
VV_RS11645	COG2067	long-chain fatty acid transport protein
VV_RS11650	COG2067	long-chain fatty acid transport protein
VV_RS11655	COG2853	Lipoprotein
VV_RS11665	COG3088	subunit of a heme lyase
VV_RS11665	COG4235	cytochrome complex assembly
VV_RS11670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VV_RS11675	COG1138	Cytochrome C-type biogenesis protein
VV_RS11680	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VV_RS11685	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV_RS11690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV_RS11695	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV_RS11700	COG4133	protoheme IX ABC transporter activity
VV_RS11710	COG0835	chemotaxis
VV_RS11720	COG1192	Involved in chromosome partitioning
VV_RS11725	COG2201	protein-glutamate methylesterase activity
VV_RS11730	COG0643	Histidine kinase
VV_RS11730	COG2198	Histidine kinase
VV_RS11730	COG0784	Response regulator, receiver
VV_RS11735	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VV_RS11770	COG1684	flagellar biosynthetic protein fliR
VV_RS11775	COG1987	bacterial-type flagellum assembly
VV_RS11825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VV_RS11835	COG1677	Flagellar hook-basal body complex protein FliE
VV_RS11855	COG1516	flagellar protein fliS
VV_RS11865	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VV_RS11870	COG1334	flagellar protein FlaG
VV_RS11875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV_RS11880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV_RS11885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV_RS11890	COG2837	iron assimilation
VV_RS11920	COG1393	Belongs to the ArsC family
VV_RS11925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VV_RS11940	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VV_RS11945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VV_RS11950	COG2716	regulation of RNA biosynthetic process
VV_RS11955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VV_RS11970	COG4783	chaperone-mediated protein folding
VV_RS11975	COG1393	Belongs to the ArsC family
VV_RS11995	COG2233	PERMEase
VV_RS12000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VV_RS12005	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VV_RS12010	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VV_RS12015	COG0121	glutamine amidotransferase
VV_RS12025	COG1960	acyl-CoA dehydrogenase activity
VV_RS12060	COG2249	NAD(P)H dehydrogenase (quinone) activity
VV_RS12075	COG0328	RNA-DNA hybrid ribonuclease activity
VV_RS12080	COG2226	methyltransferase
VV_RS12085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV_RS12090	COG1388	LysM domain
VV_RS12090	COG0741	lytic transglycosylase activity
VV_RS12100	COG3021	interspecies interaction between organisms
VV_RS12105	COG0347	Belongs to the P(II) protein family
VV_RS12115	COG0037	tRNA processing
VV_RS12120	COG0825	malonyl-CoA metabolic process
VV_RS12125	COG0587	DNA-directed DNA polymerase activity
VV_RS12130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VV_RS12135	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV_RS12140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV_RS12145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VV_RS12150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VV_RS12155	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VV_RS12160	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV_RS12165	COG0750	zinc metalloprotease
VV_RS12170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VV_RS12175	COG0575	Belongs to the CDS family
VV_RS12180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VV_RS12185	COG0233	cytoplasmic translational termination
VV_RS12190	COG0528	UMP kinase activity
VV_RS12195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VV_RS12200	COG0052	Belongs to the universal ribosomal protein uS2 family
VV_RS12205	COG0024	Methionine aminopeptidase
VV_RS12210	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VV_RS12225	COG3098	single-species biofilm formation
VV_RS12255	COG1671	Belongs to the UPF0178 family
VV_RS12260	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VV_RS12270	COG0254	rRNA binding
VV_RS12275	COG1720	tRNA m6t6A37 methyltransferase activity
VV_RS12280	COG0442	prolyl-tRNA aminoacylation
VV_RS12300	COG0733	neurotransmitter:sodium symporter activity
VV_RS12315	COG0514	ATP-dependent DNA helicase (RecQ)
VV_RS12320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VV_RS12335	COG1477	protein flavinylation
VV_RS12340	COG2871	sodium ion transport
VV_RS12345	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV_RS12350	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV_RS12355	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV_RS12360	COG1805	sodium ion transport
VV_RS12365	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VV_RS12370	COG0271	Belongs to the BolA IbaG family
VV_RS12375	COG2813	Specifically methylates the guanine in position
VV_RS12390	COG2211	Major facilitator Superfamily
VV_RS12400	COG1595	DNA-templated transcription, initiation
VV_RS12415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VV_RS12420	COG0693	protein deglycase activity
VV_RS12425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VV_RS12430	COG2166	iron-sulfur cluster assembly
VV_RS12435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VV_RS12440	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VV_RS12460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VV_RS12465	COG1074	ATP-dependent DNA helicase activity
VV_RS12470	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VV_RS12475	COG3083	sulfuric ester hydrolase activity
VV_RS12490	COG3141	response to X-ray
VV_RS12495	COG2171	N-acyltransferase activity
VV_RS12500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VV_RS12505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VV_RS12510	COG1349	DNA-binding transcription factor activity
VV_RS12515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VV_RS12530	COG0189	ligase activity
VV_RS12530	COG0569	domain protein
VV_RS12545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV_RS12555	COG0840	transmembrane signaling receptor activity
VV_RS12560	COG2017	converts alpha-aldose to the beta-anomer
VV_RS12565	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VV_RS12570	COG1085	galactose-1-phosphate uridylyltransferase
VV_RS12575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VV_RS12580	COG1609	Transcriptional regulator
VV_RS12590	COG3250	beta-galactosidase activity
VV_RS12595	COG2731	YhcH YjgK YiaL family protein
VV_RS12600	COG0531	amino acid
VV_RS12605	COG0531	amino acid
VV_RS12610	COG3408	Glycogen debranching enzyme
VV_RS12610	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
VV_RS12620	COG0583	DNA-binding transcription factor activity
VV_RS12625	COG2059	Chromate
VV_RS12675	COG4964	Belongs to the GSP D family
VV_RS12710	COG1022	Amp-dependent synthetase and ligase
VV_RS12715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VV_RS12735	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VV_RS12745	COG0560	Phosphoserine phosphatase
VV_RS12755	COG0813	purine-nucleoside phosphorylase activity
VV_RS12760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VV_RS12765	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VV_RS12770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VV_RS12775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VV_RS12780	COG0084	hydrolase, TatD family'
VV_RS12785	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VV_RS12790	COG3706	GGDEF domain
VV_RS12800	COG0456	acetyltransferase
VV_RS12810	COG3153	acetyltransferase
VV_RS12815	COG3154	lipid carrier protein
VV_RS12825	COG0826	peptidase U32
VV_RS12830	COG0826	peptidase U32
VV_RS12835	COG0534	Mate efflux family protein
VV_RS12850	COG1185	polyribonucleotide nucleotidyltransferase activity
VV_RS12880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VV_RS12885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VV_RS12890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VV_RS12895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VV_RS12900	COG0195	Participates in both transcription termination and antitermination
VV_RS12905	COG0779	Required for maturation of 30S ribosomal subunits
VV_RS12920	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VV_RS12925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV_RS12930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VV_RS12935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VV_RS12940	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VV_RS12945	COG1534	Rna-binding protein
VV_RS12965	COG2027	D-alanyl-D-alanine carboxypeptidase
VV_RS12970	COG2832	Protein of unknown function (DUF454)
VV_RS12975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VV_RS12980	COG0739	heme binding
VV_RS12995	COG0316	Belongs to the HesB IscA family
VV_RS13000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VV_RS13005	COG0628	permease
VV_RS13010	COG2813	Specifically methylates the guanine in position
VV_RS13015	COG2205	protein histidine kinase activity
VV_RS13015	COG0784	Response regulator, receiver
VV_RS13025	COG0601	transmembrane transport
VV_RS13030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV_RS13035	COG0444	Belongs to the ABC transporter superfamily
VV_RS13040	COG4608	Belongs to the ABC transporter superfamily
VV_RS13050	COG2971	BadF BadG BcrA BcrD
VV_RS13065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV_RS13080	COG1840	ABC-type Fe3 transport system, periplasmic component
VV_RS13085	COG0004	ammonium transporteR
VV_RS13090	COG0347	Belongs to the P(II) protein family
VV_RS13095	COG3112	Uncharacterised protein family (UPF0231)
VV_RS13100	COG3835	regulator
VV_RS13105	COG2610	gluconate transmembrane transporter activity
VV_RS13110	COG1929	Belongs to the glycerate kinase type-1 family
VV_RS13115	COG1049	propionate catabolic process, 2-methylcitrate cycle
VV_RS13120	COG1752	Esterase of the alpha-beta hydrolase superfamily
VV_RS13125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VV_RS13130	COG1643	Atp-dependent helicase
VV_RS13135	COG1489	DNA binding
VV_RS13140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VV_RS13145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV_RS13155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VV_RS13160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VV_RS13165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VV_RS13170	COG0842	Transport permease protein
VV_RS13175	COG1131	(ABC) transporter
VV_RS13180	COG0659	secondary active sulfate transmembrane transporter activity
VV_RS13185	COG0288	reversible hydration of carbon dioxide
VV_RS13200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV_RS13205	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV_RS13210	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VV_RS13215	COG2186	Transcriptional regulator
VV_RS13220	COG3023	N-Acetylmuramoyl-L-alanine amidase
VV_RS13235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV_RS13240	COG1459	type II secretion system
VV_RS13250	COG0237	dephospho-CoA kinase activity
VV_RS13260	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VV_RS13265	COG0335	large ribosomal subunit rRNA binding
VV_RS13270	COG0336	Belongs to the RNA methyltransferase TrmD family
VV_RS13275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VV_RS13280	COG0228	four-way junction DNA binding
VV_RS13285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VV_RS13290	COG4137	Cytochrome C assembly protein
VV_RS13295	COG4536	flavin adenine dinucleotide binding
VV_RS13300	COG1854	S-ribosylhomocysteine lyase activity
VV_RS13310	COG2918	glutathione biosynthetic process
VV_RS13315	COG0612	Peptidase, M16
VV_RS13320	COG1238	metal cluster binding
VV_RS13330	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VV_RS13335	COG5016	pyruvate
VV_RS13335	COG0511	ligase activity, forming carbon-carbon bonds
VV_RS13340	COG3630	sodium ion export across plasma membrane
VV_RS13385	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VV_RS13390	COG0527	aspartate kinase activity
VV_RS13395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VV_RS13400	COG2137	regulation of response to DNA damage stimulus
VV_RS13405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VV_RS13415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VV_RS13420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VV_RS13425	COG4942	peptidase
VV_RS13425	COG1388	LysM domain
VV_RS13430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VV_RS13435	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VV_RS13440	COG0585	pseudouridine synthase activity
VV_RS13445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VV_RS13450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VV_RS13455	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VV_RS13460	COG0148	phosphopyruvate hydratase activity
VV_RS13465	COG0504	CTP synthase activity
VV_RS13470	COG3956	TIGRFAM MazG family protein
VV_RS13475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV_RS13480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VV_RS13485	COG4999	Histidine kinase
VV_RS13485	COG3850	Histidine kinase
VV_RS13485	COG3437	response regulator, receiver
VV_RS13485	COG2205	protein histidine kinase activity
VV_RS13505	COG0736	holo-[acyl-carrier-protein] synthase activity
VV_RS13510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VV_RS13515	COG1381	Involved in DNA repair and RecF pathway recombination
VV_RS13520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VV_RS13525	COG0571	ribonuclease III activity
VV_RS13535	COG0481	GTPase activity
VV_RS13540	COG3086	response to oxidative stress
VV_RS13555	COG1595	DNA-templated transcription, initiation
VV_RS13560	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VV_RS13570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VV_RS13575	COG0354	folic acid binding
VV_RS13590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV_RS13595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VV_RS13600	COG3079	Belongs to the UPF0149 family
VV_RS13605	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VV_RS13610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VV_RS13615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VV_RS13620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VV_RS13630	COG0583	DNA-binding transcription factor activity
VV_RS13635	COG1279	arginine transmembrane transporter activity
VV_RS13640	COG0668	transmembrane transport
VV_RS13645	COG0191	fructose-bisphosphate aldolase activity
VV_RS13650	COG0126	phosphoglycerate kinase activity
VV_RS13655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VV_RS13665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VV_RS13670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VV_RS13680	COG3091	SprT-like family
VV_RS13685	COG2356	endonuclease I
VV_RS13690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VV_RS13695	COG0189	ligase activity
VV_RS13700	COG1678	Uncharacterized ACR, COG1678
VV_RS13705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VV_RS13720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VV_RS13725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VV_RS13730	COG0762	integral membrane protein
VV_RS13735	COG1872	DUF167
VV_RS13745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VV_RS13750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VV_RS13760	COG2066	Belongs to the glutaminase family
VV_RS13765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VV_RS13775	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VV_RS13915	COG3437	response regulator, receiver
VV_RS13925	COG1609	Transcriptional regulator
VV_RS13930	COG3394	polysaccharide catabolic process
VV_RS13935	COG1486	melibiose metabolic process
VV_RS13940	COG1447	Phosphotransferase system cellobiose-specific component IIA
VV_RS13950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VV_RS13955	COG0726	polysaccharide deacetylase
VV_RS13970	COG0795	lipopolysaccharide-transporting ATPase activity
VV_RS13975	COG0795	lipopolysaccharide-transporting ATPase activity
VV_RS13980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VV_RS13985	COG2927	DNA polymerase III (CHI subunit)
VV_RS13990	COG0525	valine-tRNA ligase activity
VV_RS14000	COG4269	membrane
VV_RS14010	COG0456	acetyltransferase
VV_RS14025	COG2235	arginine
VV_RS14030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VV_RS14035	COG0540	Belongs to the ATCase OTCase family
VV_RS14040	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VV_RS14045	COG0251	oxidation-reduction process
VV_RS14050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV_RS14060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VV_RS14065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VV_RS14070	COG0312	modulator of DNA gyrase
VV_RS14075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VV_RS14080	COG3164	Protein of unknown function
VV_RS14090	COG0424	maF-like protein
VV_RS14095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VV_RS14100	COG1792	Involved in formation and maintenance of cell shape
VV_RS14105	COG1077	Cell shape determining protein MreB Mrl
VV_RS14135	COG2165	general secretion pathway protein
VV_RS14140	COG2165	general secretion pathway protein
VV_RS14150	COG1459	type II secretion system
VV_RS14155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VV_RS14165	COG3409	Peptidoglycan-binding domain 1 protein
VV_RS14165	COG3267	Type II secretory pathway component ExeA
VV_RS14190	COG2200	EAL domain
VV_RS14190	COG2199	diguanylate cyclase activity
VV_RS14210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VV_RS14220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VV_RS14225	COG0527	aspartate kinase activity
VV_RS14230	COG1410	methionine synthase
VV_RS14230	COG0646	methionine synthase
VV_RS14285	COG0175	sulfate reduction
VV_RS14290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VV_RS14295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VV_RS14320	COG0735	belongs to the Fur family
VV_RS14330	COG0166	Belongs to the GPI family
VV_RS14335	COG0432	Pfam Uncharacterised protein family UPF0047
VV_RS14345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VV_RS14360	COG0359	binds to the 23S rRNA
VV_RS14370	COG2965	DNA replication, synthesis of RNA primer
VV_RS14375	COG0360	Binds together with S18 to 16S ribosomal RNA
VV_RS14380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VV_RS14385	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VV_RS14395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VV_RS14400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VV_RS14430	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VV_RS14445	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VV_RS14445	COG0165	Argininosuccinate lyase
VV_RS14450	COG0137	argininosuccinate synthase activity
VV_RS14455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VV_RS14460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VV_RS14465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VV_RS14470	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VV_RS14480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VV_RS14485	COG0527	aspartate kinase activity
VV_RS14485	COG0460	homoserine dehydrogenase
VV_RS14490	COG0626	cystathionine gamma-synthase activity
VV_RS14495	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VV_RS14500	COG0281	malic enzyme
VV_RS14505	COG0254	rRNA binding
VV_RS14510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VV_RS14515	COG1609	Transcriptional regulator
VV_RS14525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VV_RS14530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VV_RS14535	COG1575	Belongs to the MenA family. Type 1 subfamily
VV_RS14540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VV_RS14545	COG3074	FtsZ-dependent cytokinesis
VV_RS14555	COG1494	fructose-1,6-bisphosphatase
VV_RS14580	COG0149	triose-phosphate isomerase activity
VV_RS14585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VV_RS14595	COG2906	2 iron, 2 sulfur cluster binding
VV_RS14605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VV_RS14610	COG0049	tRNA binding
VV_RS14615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VV_RS14620	COG2168	tRNA wobble position uridine thiolation
VV_RS14625	COG2923	Belongs to the DsrF TusC family
VV_RS14630	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VV_RS14635	COG2964	Protein conserved in bacteria
VV_RS14640	COG0545	Peptidyl-prolyl cis-trans isomerase
VV_RS14650	COG2900	Belongs to the SlyX family
VV_RS14660	COG1047	Peptidyl-prolyl cis-trans
VV_RS14675	COG2249	NAD(P)H dehydrogenase (quinone) activity
VV_RS14680	COG0488	(ABC) transporter
VV_RS14690	COG0429	hydrolase of the alpha beta-hydrolase fold
VV_RS14695	COG3089	Belongs to the UPF0270 family
VV_RS14700	COG3954	Phosphoribulokinase
VV_RS14705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VV_RS14715	COG1012	belongs to the aldehyde dehydrogenase family
VV_RS14725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VV_RS14745	COG0180	Tryptophanyl-tRNA synthetase
VV_RS14750	COG0546	phosphoglycolate phosphatase activity
VV_RS14755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV_RS14760	COG0557	exoribonuclease II activity
VV_RS14765	COG0402	S-adenosylhomocysteine deaminase activity
VV_RS14770	COG1959	2 iron, 2 sulfur cluster binding
VV_RS14775	COG1017	nitric oxide dioxygenase activity
VV_RS14775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VV_RS14780	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VV_RS14785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VV_RS14790	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VV_RS14795	COG0330	HflC and HflK could
VV_RS14800	COG0330	HflC and HflK could
VV_RS14805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VV_RS14810	COG1923	regulation of RNA biosynthetic process
VV_RS14815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VV_RS14820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VV_RS14825	COG0860	N-Acetylmuramoyl-L-alanine amidase
VV_RS14830	COG0802	atpase or kinase
VV_RS14835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VV_RS14895	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VV_RS14900	COG1162	GTPase activity
VV_RS14905	COG0688	phosphatidylethanolamine metabolic process
VV_RS14910	COG0471	metal ion transport
VV_RS14920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VV_RS14930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VV_RS14935	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VV_RS14940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VV_RS14945	COG1045	serine acetyltransferase
VV_RS14950	COG4942	peptidase
VV_RS14955	COG3385	transposase activity
VV_RS14975	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VV_RS14980	COG1053	succinate dehydrogenase
VV_RS14985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VV_RS14990	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VV_RS14995	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VV_RS15005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VV_RS15010	COG1509	lysine 2,3-aminomutase activity
VV_RS15015	COG1285	pathogenesis
VV_RS15025	COG0459	protein refolding
VV_RS15030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VV_RS15035	COG0534	Mate efflux family protein
VV_RS15040	COG0205	6-phosphofructokinase activity
VV_RS15050	COG3678	ATP-independent chaperone mediated protein folding
VV_RS15055	COG0745	RESPONSE REGULATOR receiver
VV_RS15060	COG2205	protein histidine kinase activity
VV_RS15070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VV_RS15080	COG1027	Aspartate ammonia-lyase
VV_RS15085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VV_RS15090	COG4232	protein-disulfide reductase activity
VV_RS15100	COG2095	MarC family integral membrane protein
VV_RS15110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VV_RS15130	COG0784	Response regulator, receiver
VV_RS15130	COG2205	protein histidine kinase activity
VV_RS15130	COG2198	Histidine kinase
VV_RS15135	COG2814	Major facilitator Superfamily
VV_RS15150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VV_RS15155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VV_RS15160	COG0511	ligase activity, forming carbon-carbon bonds
VV_RS15165	COG0439	Biotin carboxylase
VV_RS15170	COG2264	protein methyltransferase activity
VV_RS15180	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VV_RS15185	COG0840	transmembrane signaling receptor activity
VV_RS15190	COG0789	Transcriptional regulator
VV_RS15195	COG0138	bifunctional purine biosynthesis protein purh
VV_RS15200	COG0151	Belongs to the GarS family
VV_RS15215	COG1253	flavin adenine dinucleotide binding
VV_RS15220	COG3068	Protein conserved in bacteria
VV_RS15225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV_RS15230	COG1573	uracil-dna glycosylase
VV_RS15235	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VV_RS15255	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VV_RS15260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VV_RS15265	COG0085	RNA polymerase activity
VV_RS15270	COG0222	ribosome binding
VV_RS15275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VV_RS15280	COG0081	regulation of translation
VV_RS15285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VV_RS15295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VV_RS15300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VV_RS15325	COG1072	(Pantothenic acid kinase))
VV_RS15330	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VV_RS15330	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VV_RS15335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VV_RS15345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VV_RS15355	COG3335	DDE superfamily endonuclease
VV_RS15395	COG2801	Transposase and inactivated derivatives
VV_RS15410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VV_RS15425	COG3118	belongs to the thioredoxin family
VV_RS15430	COG0513	Belongs to the DEAD box helicase family
VV_RS15435	COG0248	Ppx GppA phosphatase
VV_RS15440	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VV_RS15450	COG0514	ATP-dependent DNA helicase (RecQ)
VV_RS15455	COG2962	Rard protein
VV_RS15465	COG1280	lysine exporter protein (LysE YggA)
VV_RS15470	COG0210	DNA helicase
VV_RS15480	COG3220	belongs to the UPF0276 family
VV_RS15510	COG0006	proline dipeptidase activity
VV_RS15510	COG0006	proline dipeptidase activity
VV_RS15520	COG2022	thiamine diphosphate biosynthetic process
VV_RS15530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VV_RS15540	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VV_RS15545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VV_RS15550	COG2132	Multicopper oxidase
VV_RS15590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VV_RS15600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VV_RS15605	COG0408	coproporphyrinogen oxidase activity
VV_RS15610	COG0009	L-threonylcarbamoyladenylate synthase
VV_RS15615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VV_RS15620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VV_RS15630	COG0551	DNA topoisomerase type I activity
VV_RS15635	COG2922	Belongs to the Smg family
VV_RS15640	COG0758	DNA mediated transformation
VV_RS15650	COG0242	peptide deformylase activity
VV_RS15655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VV_RS15660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VV_RS15660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VV_RS15665	COG0569	domain protein
VV_RS15670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV_RS15675	COG1272	protein, Hemolysin III
VV_RS15680	COG4326	sporulation control protein
VV_RS15685	COG3084	Protein conserved in bacteria
VV_RS15695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VV_RS15700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VV_RS15705	COG0204	Acyl-transferase
VV_RS15715	COG0606	chelatase, subunit chli
VV_RS15725	COG3978	acetolactate synthase activity
VV_RS15730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VV_RS15735	COG0129	dihydroxy-acid dehydratase activity
VV_RS15745	COG0583	DNA-binding transcription factor activity
VV_RS15750	COG2814	Major facilitator Superfamily
VV_RS15760	COG0765	amino acid transport
VV_RS15765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VV_RS15770	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VV_RS15775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VV_RS15780	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VV_RS15785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VV_RS15790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VV_RS15795	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VV_RS15805	COG0356	it plays a direct role in the translocation of protons across the membrane
VV_RS15810	COG3312	ion transport
VV_RS15815	COG1475	DNA binding
VV_RS15820	COG1192	Involved in chromosome partitioning
VV_RS15825	COG0357	Ribosomal RNA small subunit methyltransferase G
VV_RS15830	COG0445	tRNA wobble uridine modification
VV_RS15850	COG0706	membrane insertase activity
VV_RS15900	COG0187	DNA topoisomerase II activity
VV_RS15960	COG0183	Belongs to the thiolase family
VV_RS16030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VV_RS16040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV_RS16150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV_RS16370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VV_RS16445	COG0784	Response regulator, receiver
VV_RS16445	COG2205	protein histidine kinase activity
VV_RS16600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VV_RS16695	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VV_RS17000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VV_RS17120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV_RS17200	COG1519	Transferase
VV_RS17225	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VV_RS17290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VV_RS17685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VV_RS17785	COG2199	diguanylate cyclase activity
VV_RS17910	COG2003	Belongs to the UPF0758 family
VV_RS18335	COG0849	cell division
VV_RS18370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VV_RS18435	COG0070	glutamate synthase
VV_RS18435	COG0067	glutamate synthase
VV_RS18435	COG0069	glutamate synthase activity
VV_RS18495	COG0784	Response regulator, receiver
VV_RS18495	COG2198	Histidine kinase
VV_RS18495	COG5002	protein histidine kinase activity
VV_RS18690	COG0728	peptidoglycan biosynthetic process
VV_RS18705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VV_RS18770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VV_RS19025	COG0124	histidyl-tRNA synthetase
VV_RS19500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VV_RS19500	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VV_RS19555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VV_RS19555	COG1263	PTS System
VV_RS19640	COG0495	leucyl-tRNA aminoacylation
VV_RS19730	COG2217	Heavy metal translocating P-type atpase
VV_RS19730	COG2608	mercury ion transmembrane transporter activity
VV_RS19820	COG1706	bacterial-type flagellum-dependent cell motility
VV_RS19830	COG1705	Flagellar rod assembly protein muramidase FlgJ
VV_RS19830	COG3951	Flagellar rod assembly protein muramidase FlgJ
VV_RS19895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VV_RS19910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VV_RS20025	COG3104	oligopeptide transport
VV_RS20080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV_RS20410	COG4191	Histidine kinase
VV_RS20450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VV_RS20670	COG3081	Nucleoid-associated protein
VV_RS20725	COG1012	belongs to the aldehyde dehydrogenase family
VV_RS20725	COG1454	alcohol dehydrogenase
VV_RS21325	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VV_RS21465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VV_RS21520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VV_RS21845	COG2814	Major facilitator Superfamily
VV_RS21885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VV_RS22360	COG0561	phosphatase activity
VV_RS22480	COG4597	amino acid ABC transporter
VV_RS22700	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VV_RS22840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VV_RS23100	COG1177	transmembrane transport
VV_RS23115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VV_RS23555	COG1040	competence protein
VV_RS23560	COG2755	lipolytic protein G-D-S-L family
VV_RS23560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VV_RS23600	COG1609	Transcriptional regulator
VV_RS23600	COG2207	Transcriptional regulator