locus-tag	class	description
CF386_RS00020	COG0076	glutamate decarboxylase activity
CF386_RS00025	COG1609	Transcriptional regulator
CF386_RS00030	COG1126	abc transporter atp-binding protein
CF386_RS00035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF386_RS00040	COG4215	(ABC) transporter
CF386_RS00045	COG4160	amino acid transport
CF386_RS00070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CF386_RS00080	COG1677	Flagellar hook-basal body complex protein FliE
CF386_RS00110	COG1987	bacterial-type flagellum assembly
CF386_RS00120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CF386_RS00135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CF386_RS00140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CF386_RS00145	COG1516	flagellar protein fliS
CF386_RS00165	COG1580	Controls the rotational direction of flagella during chemotaxis
CF386_RS00170	COG1191	sigma factor activity
CF386_RS00180	COG1360	Flagellar Motor Protein
CF386_RS00215	COG1706	bacterial-type flagellum-dependent cell motility
CF386_RS00220	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CF386_RS00225	COG4786	Flagellar basal body rod
CF386_RS00235	COG1749	Flagellar hook protein flgE
CF386_RS00240	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CF386_RS00245	COG1558	bacterial-type flagellum-dependent cell motility
CF386_RS00250	COG1815	bacterial-type flagellum-dependent cell motility
CF386_RS00255	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CF386_RS00275	COG0189	ligase activity
CF386_RS00305	COG0019	diaminopimelate decarboxylase activity
CF386_RS00340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CF386_RS00365	COG2197	response regulator
CF386_RS00380	COG2920	part of a sulfur-relay system
CF386_RS00385	COG0501	Belongs to the peptidase M48B family
CF386_RS00410	COG3070	regulator of competence-specific genes
CF386_RS00420	COG0084	hydrolase, TatD family'
CF386_RS00430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF386_RS00435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CF386_RS00460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CF386_RS00475	COG1399	metal-binding, possibly nucleic acid-binding protein
CF386_RS00480	COG0564	pseudouridine synthase activity
CF386_RS00485	COG1530	ribonuclease E activity
CF386_RS00495	COG0659	secondary active sulfate transmembrane transporter activity
CF386_RS00500	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CF386_RS00510	COG0572	uridine kinase
CF386_RS00515	COG0489	protein tyrosine kinase activity
CF386_RS00525	COG1301	dicarboxylic acid transport
CF386_RS00530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CF386_RS00550	COG4988	ABC transporter
CF386_RS00555	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CF386_RS00565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CF386_RS00570	COG0542	response to heat
CF386_RS00575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CF386_RS00590	COG0538	isocitrate dehydrogenase activity
CF386_RS00595	COG1187	pseudouridine synthase activity
CF386_RS00605	COG2915	High frequency lysogenization protein hflD homolog
CF386_RS00610	COG2915	High frequency lysogenization protein hflD homolog
CF386_RS00615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CF386_RS00620	COG2850	peptidyl-arginine hydroxylation
CF386_RS00625	COG4608	Belongs to the ABC transporter superfamily
CF386_RS00635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF386_RS00640	COG0601	transmembrane transport
CF386_RS00650	COG2198	Histidine kinase
CF386_RS00655	COG2204	response regulator
CF386_RS00660	COG0556	nucleotide-excision repair
CF386_RS00685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CF386_RS00690	COG0346	lactoylglutathione lyase activity
CF386_RS00695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF386_RS00700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CF386_RS00715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF386_RS00740	COG0616	signal peptide processing
CF386_RS00745	COG0616	signal peptide processing
CF386_RS00775	COG2719	SpoVR family
CF386_RS00780	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CF386_RS00790	COG2983	Belongs to the UPF0260 family
CF386_RS00810	COG0436	Aminotransferase
CF386_RS00815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF386_RS00825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CF386_RS00835	COG0740	serine-type endopeptidase activity
CF386_RS00855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CF386_RS00860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CF386_RS00865	COG0745	RESPONSE REGULATOR receiver
CF386_RS00870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CF386_RS00875	COG1286	toxin biosynthetic process
CF386_RS00880	COG0285	dihydrofolate synthase activity
CF386_RS00885	COG0285	dihydrofolate synthase activity
CF386_RS00895	COG0101	tRNA pseudouridine synthase activity
CF386_RS00905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CF386_RS00910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CF386_RS00915	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CF386_RS00915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CF386_RS00920	COG2860	membrane
CF386_RS00930	COG2890	protein-(glutamine-N5) methyltransferase activity
CF386_RS00935	COG1187	pseudouridine synthase activity
CF386_RS00945	COG0708	Exodeoxyribonuclease III
CF386_RS00950	COG1944	ATP diphosphatase activity
CF386_RS00960	COG2226	methyltransferase
CF386_RS00965	COG3092	negative regulation of chromosome organization
CF386_RS00970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CF386_RS00975	COG0857	belongs to the CobB CobQ family
CF386_RS00975	COG0280	phosphate acetyltransferase
CF386_RS00990	COG0674	pyruvate-flavodoxin oxidoreductase activity
CF386_RS00990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF386_RS00990	COG1013	pyruvate-flavodoxin oxidoreductase activity
CF386_RS00990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CF386_RS00995	COG1090	epimerase
CF386_RS01000	COG0300	oxidoreductase activity
CF386_RS01005	COG3118	belongs to the thioredoxin family
CF386_RS01010	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CF386_RS01015	COG2912	Transglutaminase-like superfamily
CF386_RS01020	COG2912	Transglutaminase-like superfamily
CF386_RS01025	COG2890	protein-(glutamine-N5) methyltransferase activity
CF386_RS01030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CF386_RS01035	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CF386_RS01045	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CF386_RS01050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CF386_RS01060	COG0193	aminoacyl-tRNA hydrolase activity
CF386_RS01065	COG0012	GTP binding
CF386_RS01115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF386_RS01125	COG1702	phosphate starvation-inducible protein PhoH
CF386_RS01135	COG4535	Mg2 and Co2 transporter CorC
CF386_RS01140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CF386_RS01150	COG0495	leucyl-tRNA aminoacylation
CF386_RS01165	COG0799	negative regulation of ribosome biogenesis
CF386_RS01170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CF386_RS01175	COG0768	penicillin binding
CF386_RS01180	COG1686	Belongs to the peptidase S11 family
CF386_RS01185	COG2921	Belongs to the UPF0250 family
CF386_RS01190	COG0321	lipoyl(octanoyl) transferase activity
CF386_RS01195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CF386_RS01215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CF386_RS01235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CF386_RS01240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CF386_RS01245	COG0121	glutamine amidotransferase
CF386_RS01250	COG1960	acyl-CoA dehydrogenase activity
CF386_RS01275	COG3021	interspecies interaction between organisms
CF386_RS01315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CF386_RS01320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CF386_RS01325	COG2011	ABC-type metal ion transport system permease component
CF386_RS01330	COG1464	Belongs to the NlpA lipoprotein family
CF386_RS01335	COG1720	tRNA m6t6A37 methyltransferase activity
CF386_RS01345	COG0825	malonyl-CoA metabolic process
CF386_RS01360	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CF386_RS01375	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CF386_RS01385	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF386_RS01390	COG0750	zinc metalloprotease
CF386_RS01400	COG0575	Belongs to the CDS family
CF386_RS01410	COG0233	cytoplasmic translational termination
CF386_RS01415	COG0528	UMP kinase activity
CF386_RS01425	COG0052	Belongs to the universal ribosomal protein uS2 family
CF386_RS01445	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CF386_RS01445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CF386_RS01465	COG0583	DNA-binding transcription factor activity
CF386_RS01470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CF386_RS01480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CF386_RS01490	COG1074	ATP-dependent DNA helicase activity
CF386_RS01500	COG2171	N-acyltransferase activity
CF386_RS01550	COG0542	response to heat
CF386_RS01555	COG1496	oxidoreductase activity
CF386_RS01560	COG0564	pseudouridine synthase activity
CF386_RS01565	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF386_RS01570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CF386_RS01575	COG0077	Prephenate dehydratase
CF386_RS01575	COG1605	Chorismate mutase
CF386_RS01585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF386_RS01590	COG0335	large ribosomal subunit rRNA binding
CF386_RS01595	COG0336	Belongs to the RNA methyltransferase TrmD family
CF386_RS01600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CF386_RS01605	COG0228	four-way junction DNA binding
CF386_RS01610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CF386_RS01620	COG4536	flavin adenine dinucleotide binding
CF386_RS01625	COG2918	glutathione biosynthetic process
CF386_RS01660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CF386_RS01670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CF386_RS01675	COG1058	Belongs to the CinA family
CF386_RS01675	COG1546	Belongs to the CinA family
CF386_RS01685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF386_RS01695	COG0585	pseudouridine synthase activity
CF386_RS01715	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CF386_RS01720	COG0148	phosphopyruvate hydratase activity
CF386_RS01730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CF386_RS01735	COG4999	Histidine kinase
CF386_RS01735	COG2205	protein histidine kinase activity
CF386_RS01735	COG3850	Histidine kinase
CF386_RS01735	COG3437	response regulator, receiver
CF386_RS01745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CF386_RS01750	COG1381	Involved in DNA repair and RecF pathway recombination
CF386_RS01755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CF386_RS01765	COG0481	GTPase activity
CF386_RS01770	COG3026	antisigma factor binding
CF386_RS01780	COG1595	DNA-templated transcription, initiation
CF386_RS01785	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CF386_RS01810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF386_RS01815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF386_RS01845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CF386_RS01850	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CF386_RS01855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CF386_RS01860	COG0668	transmembrane transport
CF386_RS01875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CF386_RS01880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CF386_RS01885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CF386_RS01890	COG0189	ligase activity
CF386_RS01895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CF386_RS01900	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CF386_RS01915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CF386_RS01920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CF386_RS01925	COG1194	a g-specific adenine glycosylase
CF386_RS01930	COG1194	a g-specific adenine glycosylase
CF386_RS01960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CF386_RS01975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CF386_RS01990	COG0004	ammonium transporteR
CF386_RS02005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF386_RS02010	COG0508	dehydrogenase complex catalyzes the overall conversion of
CF386_RS02015	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CF386_RS02020	COG2186	Transcriptional regulator
CF386_RS02030	COG0157	Belongs to the NadC ModD family
CF386_RS02040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CF386_RS02050	COG0237	dephospho-CoA kinase activity
CF386_RS02055	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CF386_RS02060	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CF386_RS02065	COG0494	nUDIX hydrolase
CF386_RS02075	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CF386_RS02080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CF386_RS02085	COG0849	cell division
CF386_RS02090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CF386_RS02095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CF386_RS02105	COG0772	Belongs to the SEDS family
CF386_RS02115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CF386_RS02120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CF386_RS02125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CF386_RS02135	COG0768	penicillin binding
CF386_RS02140	COG3116	cell division
CF386_RS02145	COG0275	rRNA processing
CF386_RS02155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CF386_RS02165	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CF386_RS02175	COG2969	positive regulation of protein catabolic process
CF386_RS02180	COG0625	glutathione transferase activity
CF386_RS02185	COG2857	Cytochrome c1
CF386_RS02190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CF386_RS02195	COG0723	plastoquinol--plastocyanin reductase activity
CF386_RS02200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CF386_RS02205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CF386_RS02210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CF386_RS02220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF386_RS02230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CF386_RS02235	COG5007	Belongs to the BolA IbaG family
CF386_RS02240	COG2854	intermembrane phospholipid transfer
CF386_RS02245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CF386_RS02250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CF386_RS02255	COG1127	ABC transporter
CF386_RS02265	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CF386_RS02275	COG1137	ATPase activity
CF386_RS02280	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CF386_RS02285	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CF386_RS02290	COG1660	Displays ATPase and GTPase activities
CF386_RS02295	COG1686	Belongs to the peptidase S11 family
CF386_RS02300	COG3028	Belongs to the UPF0307 family
CF386_RS02325	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CF386_RS02330	COG1792	Involved in formation and maintenance of cell shape
CF386_RS02335	COG1077	Cell shape determining protein MreB Mrl
CF386_RS02340	COG2200	EAL domain
CF386_RS02340	COG2199	diguanylate cyclase activity
CF386_RS02355	COG0629	single-stranded DNA binding
CF386_RS02360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CF386_RS02370	COG0527	aspartate kinase activity
CF386_RS02380	COG4689	acetoacetate decarboxylase
CF386_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
CF386_RS02395	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CF386_RS02400	COG0203	ribosomal protein L17
CF386_RS02405	COG0202	RNA polymerase activity
CF386_RS02410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CF386_RS02415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CF386_RS02420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CF386_RS02425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CF386_RS02430	COG0201	protein transport
CF386_RS02435	COG0200	Binds to the 23S rRNA
CF386_RS02440	COG1841	ribosomal large subunit assembly
CF386_RS02445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CF386_RS02455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CF386_RS02465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CF386_RS02470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CF386_RS02480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CF386_RS02485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CF386_RS02490	COG0255	Belongs to the universal ribosomal protein uL29 family
CF386_RS02495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CF386_RS02500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CF386_RS02505	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CF386_RS02510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CF386_RS02515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CF386_RS02525	COG0088	Forms part of the polypeptide exit tunnel
CF386_RS02530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CF386_RS02535	COG0051	transcription antitermination factor activity, RNA binding
CF386_RS02545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CF386_RS02550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CF386_RS02555	COG0049	tRNA binding
CF386_RS02570	COG2923	Belongs to the DsrF TusC family
CF386_RS02575	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CF386_RS02580	COG0545	Peptidyl-prolyl cis-trans isomerase
CF386_RS02620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CF386_RS02635	COG0180	Tryptophanyl-tRNA synthetase
CF386_RS02640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CF386_RS02645	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CF386_RS02650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CF386_RS02655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CF386_RS02660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CF386_RS02665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CF386_RS02680	COG0626	cystathionine gamma-synthase activity
CF386_RS02690	COG0254	rRNA binding
CF386_RS02700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CF386_RS02710	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CF386_RS02715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CF386_RS02720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CF386_RS02725	COG3074	FtsZ-dependent cytokinesis
CF386_RS02730	COG1494	fructose-1,6-bisphosphatase
CF386_RS02735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF386_RS02740	COG0149	triose-phosphate isomerase activity
CF386_RS02750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CF386_RS02755	COG0745	RESPONSE REGULATOR receiver
CF386_RS02765	COG2205	protein histidine kinase activity
CF386_RS02770	COG2205	protein histidine kinase activity
CF386_RS02775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CF386_RS02785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CF386_RS02790	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CF386_RS02795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF386_RS02830	COG1519	Transferase
CF386_RS02840	COG0859	PFAM glycosyl transferase family 9
CF386_RS02855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CF386_RS02860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CF386_RS02870	COG0756	dUTP diphosphatase activity
CF386_RS02875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CF386_RS02880	COG1561	YicC-like family, N-terminal region
CF386_RS02885	COG0194	GDP metabolic process
CF386_RS02895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CF386_RS02900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF386_RS02905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CF386_RS02925	COG0552	protein localization to endoplasmic reticulum
CF386_RS02930	COG0742	ribosomal rna small subunit methyltransferase
CF386_RS02935	COG2095	MarC family integral membrane protein
CF386_RS02940	COG0561	phosphatase activity
CF386_RS02945	COG2081	HI0933 family
CF386_RS02955	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CF386_RS02965	COG3118	belongs to the thioredoxin family
CF386_RS02970	COG0513	Belongs to the DEAD box helicase family
CF386_RS02975	COG0248	Ppx GppA phosphatase
CF386_RS02980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CF386_RS02985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF386_RS03020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF386_RS03025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF386_RS03030	COG2960	long-chain fatty acid transporting porin activity
CF386_RS03035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CF386_RS03100	COG0408	coproporphyrinogen oxidase activity
CF386_RS03105	COG0009	L-threonylcarbamoyladenylate synthase
CF386_RS03110	COG0009	L-threonylcarbamoyladenylate synthase
CF386_RS03115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CF386_RS03120	COG2922	Belongs to the Smg family
CF386_RS03125	COG0242	peptide deformylase activity
CF386_RS03130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CF386_RS03135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CF386_RS03135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CF386_RS03140	COG0569	domain protein
CF386_RS03170	COG1086	Polysaccharide biosynthesis protein
CF386_RS03190	COG1083	cytidylyl-transferase
CF386_RS03195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CF386_RS03200	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CF386_RS03205	COG2089	acid synthase
CF386_RS03215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CF386_RS03220	COG1088	dTDP-glucose 4,6-dehydratase activity
CF386_RS03225	COG1132	(ABC) transporter
CF386_RS03235	COG0583	DNA-binding transcription factor activity
CF386_RS03245	COG0129	dihydroxy-acid dehydratase activity
CF386_RS03250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF386_RS03260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CF386_RS03265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CF386_RS03270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CF386_RS03275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CF386_RS03285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CF386_RS03295	COG0356	it plays a direct role in the translocation of protons across the membrane
CF386_RS03300	COG3312	ion transport
CF386_RS03305	COG1475	DNA binding
CF386_RS03310	COG1192	Involved in chromosome partitioning
CF386_RS03315	COG0357	Ribosomal RNA small subunit methyltransferase G
CF386_RS03320	COG0445	tRNA wobble uridine modification
CF386_RS03335	COG0706	membrane insertase activity
CF386_RS03340	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CF386_RS03355	COG1126	abc transporter atp-binding protein
CF386_RS03370	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CF386_RS03375	COG0592	DNA-directed DNA polymerase activity
CF386_RS03380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CF386_RS03385	COG0187	DNA topoisomerase II activity
CF386_RS03390	COG0751	glycine-tRNA ligase activity
CF386_RS03395	COG0752	glycyl-tRNA synthetase alpha subunit
CF386_RS03400	COG0425	Belongs to the sulfur carrier protein TusA family
CF386_RS03405	COG0604	alcohol dehydrogenase
CF386_RS03410	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CF386_RS03460	COG0006	proline dipeptidase activity
CF386_RS03475	COG3165	ubiquinone biosynthetic process from chorismate
CF386_RS03480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CF386_RS03485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF386_RS03495	COG0805	protein transport
CF386_RS03500	COG3119	arylsulfatase activity
CF386_RS03505	COG0641	radical SAM
CF386_RS03515	COG1297	OPT oligopeptide transporter protein
CF386_RS03550	COG0181	hydroxymethylbilane synthase activity
CF386_RS03560	COG1965	Belongs to the frataxin family
CF386_RS03570	COG0019	diaminopimelate decarboxylase activity
CF386_RS03575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CF386_RS03585	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CF386_RS03605	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CF386_RS03615	COG3078	GTPase activator activity
CF386_RS03625	COG3852	Histidine kinase
CF386_RS03630	COG0174	glutamine synthetase
CF386_RS03635	COG1217	gtp-binding protein TYPA
CF386_RS03645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CF386_RS03650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CF386_RS03655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CF386_RS03660	COG3031	protein transport across the cell outer membrane
CF386_RS03670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF386_RS03675	COG1459	type II secretion system
CF386_RS03680	COG2165	general secretion pathway protein
CF386_RS03705	COG3156	type II secretion system protein K
CF386_RS03730	COG0494	nUDIX hydrolase
CF386_RS03735	COG1918	ferrous iron import across plasma membrane
CF386_RS03740	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CF386_RS03765	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CF386_RS03790	COG0109	protoheme IX farnesyltransferase activity
CF386_RS03795	COG0109	protoheme IX farnesyltransferase activity
CF386_RS03810	COG0596	Alpha beta hydrolase
CF386_RS03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF386_RS03830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CF386_RS03860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CF386_RS03865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CF386_RS03895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CF386_RS03900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CF386_RS03905	COG0250	Participates in transcription elongation, termination and antitermination
CF386_RS03915	COG0081	regulation of translation
CF386_RS03930	COG0085	RNA polymerase activity
CF386_RS03935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CF386_RS03940	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CF386_RS03945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CF386_RS03960	COG0151	Belongs to the GarS family
CF386_RS03975	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CF386_RS03990	COG0439	Biotin carboxylase
CF386_RS03995	COG0511	ligase activity, forming carbon-carbon bonds
CF386_RS04005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CF386_RS04010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CF386_RS04015	COG4232	protein-disulfide reductase activity
CF386_RS04025	COG0459	protein refolding
CF386_RS04030	COG1509	lysine 2,3-aminomutase activity
CF386_RS04035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CF386_RS04050	COG0688	phosphatidylethanolamine metabolic process
CF386_RS04080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CF386_RS04085	COG0802	atpase or kinase
CF386_RS04095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CF386_RS04100	COG1923	regulation of RNA biosynthetic process
CF386_RS04105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CF386_RS04110	COG0330	HflC and HflK could
CF386_RS04115	COG0330	HflC and HflK could
CF386_RS04120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CF386_RS04125	COG0557	exoribonuclease II activity
CF386_RS04135	COG0360	Binds together with S18 to 16S ribosomal RNA
CF386_RS04140	COG2965	DNA replication, synthesis of RNA primer
CF386_RS04150	COG0359	binds to the 23S rRNA
CF386_RS04165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CF386_RS04170	COG0166	Belongs to the GPI family
CF386_RS04175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF386_RS04180	COG0545	Peptidyl-prolyl cis-trans isomerase
CF386_RS04215	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF386_RS04220	COG2911	Protein conserved in bacteria
CF386_RS04225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CF386_RS04230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CF386_RS04235	COG1438	arginine binding
CF386_RS04240	COG0039	L-malate dehydrogenase activity
CF386_RS04245	COG0142	geranyltranstransferase activity
CF386_RS04250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CF386_RS04260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CF386_RS04265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CF386_RS04270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CF386_RS04280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CF386_RS04285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CF386_RS04290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF386_RS04295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF386_RS04300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CF386_RS04305	COG0564	pseudouridine synthase activity
CF386_RS04310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CF386_RS04320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CF386_RS04325	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CF386_RS04330	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CF386_RS04335	COG1178	ABC-type Fe3 transport system permease component
CF386_RS04340	COG4143	(ABC) transporter
CF386_RS04345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CF386_RS04350	COG0028	Belongs to the TPP enzyme family
CF386_RS04355	COG0440	acetolactate synthase activity
CF386_RS04360	COG0469	pyruvate kinase activity
CF386_RS04370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF386_RS04380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CF386_RS04385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CF386_RS04390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CF386_RS04405	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CF386_RS04410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CF386_RS04415	COG1560	Kdo2-lipid A biosynthetic process
CF386_RS04425	COG1538	Outer membrane efflux protein
CF386_RS04440	COG0494	nUDIX hydrolase
CF386_RS04460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CF386_RS04465	COG0251	oxidation-reduction process
CF386_RS04470	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CF386_RS04485	COG0525	valine-tRNA ligase activity
CF386_RS04500	COG0795	lipopolysaccharide-transporting ATPase activity
CF386_RS04545	COG2813	Specifically methylates the guanine in position
CF386_RS04550	COG0628	permease
CF386_RS04560	COG0038	chloride channel
CF386_RS04565	COG0316	Belongs to the HesB IscA family
CF386_RS04570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CF386_RS04575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF386_RS04580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CF386_RS04585	COG0493	'glutamate synthase
CF386_RS04590	COG0067	glutamate synthase
CF386_RS04590	COG0069	glutamate synthase activity
CF386_RS04590	COG0070	glutamate synthase
CF386_RS04595	COG0784	Response regulator, receiver
CF386_RS04595	COG2198	Histidine kinase
CF386_RS04595	COG5002	protein histidine kinase activity
CF386_RS04600	COG0745	RESPONSE REGULATOR receiver
CF386_RS04605	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CF386_RS04615	COG0083	homoserine kinase activity
CF386_RS04620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CF386_RS04625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CF386_RS04630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CF386_RS04640	COG3022	response to hydroperoxide
CF386_RS04655	COG0513	Belongs to the DEAD box helicase family
CF386_RS04660	COG0513	Belongs to the DEAD box helicase family
CF386_RS04665	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CF386_RS04670	COG0716	FMN binding
CF386_RS04675	COG4974	Belongs to the 'phage' integrase family
CF386_RS04680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CF386_RS04690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CF386_RS04695	COG3066	DNA modification
CF386_RS04700	COG0494	nUDIX hydrolase
CF386_RS04705	COG0730	response to heat
CF386_RS04710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CF386_RS04715	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CF386_RS04720	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CF386_RS04725	COG0268	Binds directly to 16S ribosomal RNA
CF386_RS04730	COG0728	peptidoglycan biosynthetic process
CF386_RS04735	COG0196	riboflavin kinase activity
CF386_RS04740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CF386_RS04750	COG1047	Peptidyl-prolyl cis-trans
CF386_RS04755	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CF386_RS04760	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CF386_RS04770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CF386_RS04780	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF386_RS04785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF386_RS04790	COG1534	Rna-binding protein
CF386_RS04795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CF386_RS04800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CF386_RS04805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CF386_RS04815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CF386_RS04830	COG0779	Required for maturation of 30S ribosomal subunits
CF386_RS04835	COG0195	Participates in both transcription termination and antitermination
CF386_RS04840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CF386_RS04845	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CF386_RS04850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CF386_RS04860	COG1185	polyribonucleotide nucleotidyltransferase activity
CF386_RS04875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CF386_RS04880	COG0084	hydrolase, TatD family'
CF386_RS04890	COG0560	Phosphoserine phosphatase
CF386_RS04895	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CF386_RS04900	COG0488	(ABC) transporter
CF386_RS04905	COG0741	lytic transglycosylase activity
CF386_RS04920	COG1007	ATP synthesis coupled electron transport
CF386_RS04925	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF386_RS04940	COG0839	Belongs to the complex I subunit 6 family
CF386_RS04950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CF386_RS04955	COG1034	ATP synthesis coupled electron transport
CF386_RS04960	COG1034	ATP synthesis coupled electron transport
CF386_RS04970	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CF386_RS04975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF386_RS04975	COG0649	NAD binding
CF386_RS04985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF386_RS05005	COG0438	transferase activity, transferring glycosyl groups
CF386_RS05010	COG0463	Glycosyl transferase, family 2
CF386_RS05015	COG1129	ABC transporter
CF386_RS05035	COG2867	negative regulation of translational initiation
CF386_RS05040	COG2914	Belongs to the UPF0125 (RnfH) family
CF386_RS05045	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF386_RS05050	COG0497	DNA recombination
CF386_RS05055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CF386_RS05060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CF386_RS05065	COG0443	Heat shock 70 kDa protein
CF386_RS05075	COG2974	May be involved in recombination
CF386_RS05085	COG5002	protein histidine kinase activity
CF386_RS05105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CF386_RS05115	COG0450	alkyl hydroperoxide reductase
CF386_RS05120	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CF386_RS05135	COG0343	queuine tRNA-ribosyltransferase activity
CF386_RS05140	COG1862	Preprotein translocase
CF386_RS05145	COG0483	inositol monophosphate 1-phosphatase activity
CF386_RS05150	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CF386_RS05160	COG1104	cysteine desulfurase activity
CF386_RS05165	COG0822	iron-sulfur transferase activity
CF386_RS05170	COG0316	Belongs to the HesB IscA family
CF386_RS05175	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CF386_RS05180	COG0443	Heat shock 70 kDa protein
CF386_RS05185	COG0633	Ferredoxin
CF386_RS05215	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CF386_RS05230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF386_RS05235	COG1160	GTP binding
CF386_RS05245	COG0668	transmembrane transport
CF386_RS05250	COG1570	exodeoxyribonuclease VII activity
CF386_RS05255	COG0516	GMP reductase activity
CF386_RS05255	COG0517	IMP dehydrogenase activity
CF386_RS05260	COG0519	Catalyzes the synthesis of GMP from XMP
CF386_RS05260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CF386_RS05270	COG0047	phosphoribosylformylglycinamidine synthase activity
CF386_RS05270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CF386_RS05280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CF386_RS05285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF386_RS05285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF386_RS05295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CF386_RS05305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CF386_RS05310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CF386_RS05315	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CF386_RS05320	COG0142	geranyltranstransferase activity
CF386_RS05325	COG1722	exodeoxyribonuclease VII activity
CF386_RS05350	COG2813	Specifically methylates the guanine in position
CF386_RS05355	COG2813	Specifically methylates the guanine in position
CF386_RS05360	COG0271	Belongs to the BolA IbaG family
CF386_RS05365	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CF386_RS05370	COG1805	sodium ion transport
CF386_RS05375	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CF386_RS05385	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CF386_RS05390	COG2871	sodium ion transport
CF386_RS05395	COG1477	protein flavinylation
CF386_RS05400	COG1477	protein flavinylation
CF386_RS05410	COG2195	Cleaves the N-terminal amino acid of tripeptides
CF386_RS05415	COG2252	PERMEase
CF386_RS05420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CF386_RS05425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CF386_RS05430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CF386_RS05440	COG1876	peptidase activity
CF386_RS05445	COG1876	peptidase activity
CF386_RS05455	COG1393	Belongs to the ArsC family
CF386_RS05460	COG0484	heat shock protein binding
CF386_RS05470	COG2190	(PTS) system
CF386_RS05480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF386_RS05490	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CF386_RS05495	COG3115	cell septum assembly
CF386_RS05505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CF386_RS05520	COG4133	protoheme IX ABC transporter activity
CF386_RS05530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF386_RS05545	COG1138	Cytochrome C-type biogenesis protein
CF386_RS05550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CF386_RS05555	COG4235	cytochrome complex assembly
CF386_RS05555	COG3088	subunit of a heme lyase
CF386_RS05570	COG0183	Belongs to the thiolase family
CF386_RS05575	COG1024	Enoyl-CoA hydratase
CF386_RS05575	COG1250	3-hydroxyacyl-CoA dehydrogenase
CF386_RS05580	COG1250	3-hydroxyacyl-CoA dehydrogenase
CF386_RS05580	COG1024	Enoyl-CoA hydratase
CF386_RS05585	COG1024	Enoyl-CoA hydratase
CF386_RS05585	COG1250	3-hydroxyacyl-CoA dehydrogenase
CF386_RS05590	COG1025	Belongs to the peptidase M16 family
CF386_RS05600	COG1522	sequence-specific DNA binding
CF386_RS05620	COG2832	Protein of unknown function (DUF454)
CF386_RS05625	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CF386_RS05630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CF386_RS05635	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CF386_RS05640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CF386_RS05650	COG0326	Molecular chaperone. Has ATPase activity
CF386_RS05655	COG0563	adenylate kinase activity
CF386_RS05660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CF386_RS05665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF386_RS05670	COG0367	asparagine synthase
CF386_RS05675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF386_RS05685	COG2190	(PTS) system
CF386_RS05685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF386_RS05685	COG1263	PTS System
CF386_RS05690	COG2094	Belongs to the DNA glycosylase MPG family
CF386_RS05695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CF386_RS05700	COG0735	belongs to the Fur family
CF386_RS05705	COG0716	FMN binding
CF386_RS05715	COG0596	Alpha beta hydrolase
CF386_RS05720	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CF386_RS05725	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CF386_RS05730	COG0033	Phosphoglucomutase
CF386_RS05735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CF386_RS05750	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CF386_RS05755	COG1053	succinate dehydrogenase
CF386_RS05765	COG0567	Dehydrogenase, E1 component
CF386_RS05770	COG0508	dehydrogenase complex catalyzes the overall conversion of
CF386_RS05775	COG0045	succinate-CoA ligase (ADP-forming) activity
CF386_RS05780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF386_RS05785	COG0739	heme binding
CF386_RS05795	COG1199	ATP-dependent helicase activity
CF386_RS05800	COG1214	PFAM Peptidase M22, glycoprotease
CF386_RS05805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CF386_RS05815	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CF386_RS05820	COG2894	cell division
CF386_RS05825	COG0850	regulation of cytokinetic process
CF386_RS05830	COG3100	YcgL domain-containing protein
CF386_RS05845	COG0107	imidazoleglycerol-phosphate synthase activity
CF386_RS05850	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CF386_RS05855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CF386_RS05860	COG0131	Imidazoleglycerol-phosphate dehydratase
CF386_RS05860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CF386_RS05865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CF386_RS05870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CF386_RS05875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CF386_RS05880	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CF386_RS05885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CF386_RS05890	COG0215	cysteine-tRNA ligase activity
CF386_RS05895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF386_RS05900	COG2095	MarC family integral membrane protein
CF386_RS05920	COG4067	protein conserved in archaea
CF386_RS05920	COG0189	ligase activity
CF386_RS05930	COG4106	trans-aconitate 2-methyltransferase activity
CF386_RS05935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CF386_RS05945	COG0581	inorganic phosphate transmembrane transporter activity
CF386_RS05950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CF386_RS05955	COG1278	Cold shock
CF386_RS05965	COG0217	transcriptional regulatory protein
CF386_RS05970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CF386_RS05975	COG0632	four-way junction helicase activity
CF386_RS05980	COG2255	four-way junction helicase activity
CF386_RS05990	COG0811	peptide transport
CF386_RS06005	COG0823	Involved in the tonB-independent uptake of proteins
CF386_RS06010	COG2885	chlorophyll binding
CF386_RS06020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CF386_RS06035	COG0564	pseudouridine synthase activity
CF386_RS06050	COG2917	probably involved in intracellular septation
CF386_RS06060	COG2193	ferroxidase activity
CF386_RS06065	COG0135	phosphoribosylanthranilate isomerase activity
CF386_RS06065	COG0134	indole-3-glycerol-phosphate synthase activity
CF386_RS06070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CF386_RS06075	COG0613	PHP domain protein
CF386_RS06080	COG0009	L-threonylcarbamoyladenylate synthase
CF386_RS06090	COG0616	signal peptide processing
CF386_RS06105	COG0583	DNA-binding transcription factor activity
CF386_RS06110	COG0679	Auxin Efflux Carrier
CF386_RS06115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF386_RS06120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF386_RS06125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF386_RS06130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CF386_RS06145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CF386_RS06150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CF386_RS06155	COG0539	negative regulation of cytoplasmic translation
CF386_RS06170	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CF386_RS06190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF386_RS06205	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CF386_RS06220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF386_RS06225	COG1760	l-serine dehydratase
CF386_RS06235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CF386_RS06240	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF386_RS06240	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF386_RS06245	COG0418	dihydroorotase activity
CF386_RS06250	COG0537	adenosine 5'-monophosphoramidase activity
CF386_RS06270	COG1252	NADH dehydrogenase
CF386_RS06275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CF386_RS06280	COG4591	ABC-type transport system involved in lipoprotein release permease component
CF386_RS06290	COG4591	ABC-type transport system involved in lipoprotein release permease component
CF386_RS06300	COG1132	(ABC) transporter
CF386_RS06305	COG1663	tetraacyldisaccharide 4'-kinase activity
CF386_RS06310	COG2835	tetraacyldisaccharide 4'-kinase activity
CF386_RS06315	COG0730	response to heat
CF386_RS06325	COG1448	Aminotransferase
CF386_RS06335	COG0017	Asparaginyl-tRNA synthetase
CF386_RS06340	COG0720	synthase
CF386_RS06345	COG0602	queuosine metabolic process
CF386_RS06350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CF386_RS06355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CF386_RS06360	COG0156	8-amino-7-oxononanoate synthase activity
CF386_RS06365	COG2226	methyltransferase
CF386_RS06370	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CF386_RS06375	COG0670	Belongs to the BI1 family
CF386_RS06380	COG1126	abc transporter atp-binding protein
CF386_RS06390	COG4597	amino acid ABC transporter
CF386_RS06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF386_RS06410	COG3724	N-succinylarginine dihydrolase activity
CF386_RS06415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF386_RS06420	COG1120	ATPase activity
CF386_RS06435	COG0738	Major facilitator superfamily
CF386_RS06440	COG0800	Aldolase
CF386_RS06445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF386_RS06460	COG0246	Mannitol dehydrogenase
CF386_RS06465	COG2721	sulfolactate sulfo-lyase activity
CF386_RS06475	COG0534	Mate efflux family protein
CF386_RS06485	COG1131	(ABC) transporter
CF386_RS06500	COG1063	alcohol dehydrogenase
CF386_RS06505	COG1802	Transcriptional regulator
CF386_RS06515	COG0837	glucose binding
CF386_RS06535	COG4667	esterase of the alpha-beta hydrolase superfamily
CF386_RS06540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CF386_RS06550	COG3313	Fe-S protein
CF386_RS06555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CF386_RS06560	COG1061	Type III restriction enzyme res subunit
CF386_RS06570	COG1187	pseudouridine synthase activity
CF386_RS06580	COG4181	ATPase activity
CF386_RS06605	COG0210	DNA helicase
CF386_RS06610	COG1803	Methylglyoxal synthase
CF386_RS06615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CF386_RS06645	COG1177	transmembrane transport
CF386_RS06655	COG3842	ATPase activity
CF386_RS06680	COG0302	gtp cyclohydrolase
CF386_RS06685	COG0861	Integral membrane protein TerC family
CF386_RS06690	COG0113	porphobilinogen synthase activity
CF386_RS06695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CF386_RS06695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CF386_RS06700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CF386_RS06700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CF386_RS06705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF386_RS06720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF386_RS06720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF386_RS06725	COG4067	protein conserved in archaea
CF386_RS06725	COG0189	ligase activity
CF386_RS06730	COG2176	DNA-directed DNA polymerase activity
CF386_RS06740	COG1131	(ABC) transporter
CF386_RS06745	COG0842	Transport permease protein
CF386_RS06760	COG3148	PFAM DTW domain containing protein
CF386_RS06775	COG1940	carbohydrate kinase activity
CF386_RS06780	COG3639	organic phosphonate transmembrane transporter activity
CF386_RS06800	COG2188	Transcriptional regulator
CF386_RS06805	COG3624	Phosphonate C-P lyase system protein PhnG
CF386_RS06810	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CF386_RS06820	COG3627	carbon phosphorus lyase activity
CF386_RS06825	COG4107	phosphonate C-P lyase system protein PhnK
CF386_RS06830	COG4778	phosphonate C-P lyase system protein PhnL
CF386_RS06835	COG3454	Phosphonate metabolism
CF386_RS06845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CF386_RS06865	COG2949	membrane
CF386_RS06870	COG0281	malic enzyme
CF386_RS06880	COG1643	Atp-dependent helicase
CF386_RS06895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CF386_RS06895	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CF386_RS06900	COG1956	GAF domain-containing protein
CF386_RS06905	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CF386_RS06910	COG0793	Belongs to the peptidase S41A family
CF386_RS06915	COG0793	Belongs to the peptidase S41A family
CF386_RS06920	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CF386_RS06925	COG0308	aminopeptidase N
CF386_RS06930	COG2902	Dehydrogenase
CF386_RS06935	COG0167	dihydroorotate dehydrogenase activity
CF386_RS06955	COG3130	regulation of translation
CF386_RS06960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CF386_RS06965	COG1067	ATP-dependent peptidase activity
CF386_RS06970	COG3120	sequence-specific DNA binding
CF386_RS06995	COG1846	Transcriptional regulator
CF386_RS07005	COG0574	Belongs to the PEP-utilizing enzyme family
CF386_RS07005	COG3848	Pyruvate phosphate dikinase
CF386_RS07045	COG1138	Cytochrome C-type biogenesis protein
CF386_RS07050	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CF386_RS07060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF386_RS07090	COG0513	Belongs to the DEAD box helicase family
CF386_RS07100	COG0387	Pfam Sodium calcium exchanger
CF386_RS07130	COG3278	Belongs to the heme-copper respiratory oxidase family
CF386_RS07155	COG2217	Heavy metal translocating P-type atpase
CF386_RS07185	COG0667	Aldo Keto reductase
CF386_RS07195	COG3279	Response regulator of the LytR AlgR family
CF386_RS07215	COG1881	PFAM PEBP family protein
CF386_RS07220	COG2755	lipolytic protein G-D-S-L family
CF386_RS07220	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CF386_RS07225	COG0488	(ABC) transporter
CF386_RS07235	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CF386_RS07245	COG2988	succinylglutamate desuccinylase activity
CF386_RS07250	COG2988	succinylglutamate desuccinylase activity
CF386_RS07270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CF386_RS07280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CF386_RS07285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CF386_RS07295	COG1716	ATPase activity
CF386_RS07295	COG5001	Diguanylate cyclase
CF386_RS07325	COG0463	Glycosyl transferase, family 2
CF386_RS07335	COG0583	DNA-binding transcription factor activity
CF386_RS07340	COG1279	arginine transmembrane transporter activity
CF386_RS07415	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CF386_RS07430	COG0697	spore germination
CF386_RS07440	COG2814	Major facilitator Superfamily
CF386_RS07475	COG0531	amino acid
CF386_RS07480	COG0531	amino acid
CF386_RS07485	COG1522	sequence-specific DNA binding
CF386_RS07490	COG0583	DNA-binding transcription factor activity
CF386_RS07495	COG2814	Major facilitator Superfamily
CF386_RS07510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CF386_RS07515	COG1032	radical SAM domain protein
CF386_RS07530	COG0436	Aminotransferase
CF386_RS07535	COG2999	glutathione oxidoreductase activity
CF386_RS07585	COG0778	Nitroreductase
CF386_RS07590	COG2814	Major facilitator Superfamily
CF386_RS07605	COG0477	Major facilitator Superfamily
CF386_RS07650	COG1028	Short-chain dehydrogenase reductase Sdr
CF386_RS07710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CF386_RS07715	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CF386_RS07720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CF386_RS07720	COG0517	IMP dehydrogenase activity
CF386_RS07730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CF386_RS07735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CF386_RS07740	COG0133	tryptophan synthase activity
CF386_RS07770	COG0509	glycine decarboxylation via glycine cleavage system
CF386_RS07775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CF386_RS07780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CF386_RS07795	COG4619	ABC transporter
CF386_RS07800	COG0390	transport system, permease component
CF386_RS07805	COG0513	Belongs to the DEAD box helicase family
CF386_RS07810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CF386_RS07815	COG0581	inorganic phosphate transmembrane transporter activity
CF386_RS07820	COG0573	inorganic phosphate transmembrane transporter activity
CF386_RS07830	COG2608	mercury ion transmembrane transporter activity
CF386_RS07830	COG2217	Heavy metal translocating P-type atpase
CF386_RS07835	COG2217	Heavy metal translocating P-type atpase
CF386_RS07850	COG0583	DNA-binding transcription factor activity
CF386_RS07855	COG0534	Mate efflux family protein
CF386_RS07880	COG0402	S-adenosylhomocysteine deaminase activity
CF386_RS07910	COG1562	ergosterol biosynthetic process
CF386_RS07935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CF386_RS07955	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF386_RS07960	COG0625	glutathione transferase activity
CF386_RS07965	COG1280	lysine exporter protein (LysE YggA)
CF386_RS07970	COG2962	Rard protein
CF386_RS08000	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CF386_RS08005	COG1054	Belongs to the UPF0176 family
CF386_RS08015	COG3038	cytochrome b561
CF386_RS08040	COG3279	Response regulator of the LytR AlgR family
CF386_RS08050	COG5002	protein histidine kinase activity
CF386_RS08050	COG2198	Histidine kinase
CF386_RS08050	COG0784	Response regulator, receiver
CF386_RS08060	COG2197	response regulator
CF386_RS08065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF386_RS08105	COG0398	Pfam SNARE associated Golgi protein
CF386_RS08110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF386_RS08120	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CF386_RS08125	COG1136	(ABC) transporter
CF386_RS08185	COG2076	Multidrug Resistance protein
CF386_RS08200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CF386_RS08205	COG2153	protein acetylation
CF386_RS08215	COG0583	DNA-binding transcription factor activity
CF386_RS08235	COG0531	amino acid
CF386_RS08245	COG2217	Heavy metal translocating P-type atpase
CF386_RS08255	COG2814	Major facilitator Superfamily
CF386_RS08270	COG0561	phosphatase activity
CF386_RS08280	COG0114	fumarate hydratase activity
CF386_RS08290	COG4977	sequence-specific DNA binding
CF386_RS08295	COG4977	sequence-specific DNA binding
CF386_RS08315	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CF386_RS08320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CF386_RS08330	COG0137	argininosuccinate synthase activity
CF386_RS08335	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CF386_RS08335	COG0165	Argininosuccinate lyase
CF386_RS08400	COG3279	Response regulator of the LytR AlgR family
CF386_RS08410	COG0583	DNA-binding transcription factor activity
CF386_RS08420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CF386_RS08445	COG0415	Belongs to the DNA photolyase family
CF386_RS08450	COG3046	protein related to deoxyribodipyrimidine photolyase
CF386_RS08500	COG0415	Belongs to the DNA photolyase family
CF386_RS08505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CF386_RS08510	COG0814	amino acid
CF386_RS08515	COG0814	amino acid
CF386_RS08520	COG0814	amino acid
CF386_RS08545	COG0307	riboflavin synthase, alpha
CF386_RS08550	COG2249	NAD(P)H dehydrogenase (quinone) activity
CF386_RS08590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF386_RS08650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CF386_RS08675	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CF386_RS08680	COG1715	Restriction endonuclease
CF386_RS08700	COG1794	racemase activity, acting on amino acids and derivatives
CF386_RS08820	COG5642	Protein of unknown function (DUF2384)
CF386_RS08830	COG0673	inositol 2-dehydrogenase activity
CF386_RS08835	COG0697	spore germination
CF386_RS08845	COG2814	Major facilitator Superfamily
CF386_RS08880	COG0583	DNA-binding transcription factor activity
CF386_RS08890	COG2814	Major facilitator Superfamily
CF386_RS08895	COG2207	Transcriptional regulator
CF386_RS08925	COG0583	DNA-binding transcription factor activity
CF386_RS08950	COG0463	Glycosyl transferase, family 2
CF386_RS09040	COG0385	Bile acid
CF386_RS09045	COG2154	pterin-4-alpha-carbinolamine dehydratase
CF386_RS09050	COG2329	Antibiotic biosynthesis monooxygenase
CF386_RS09065	COG0346	lactoylglutathione lyase activity
CF386_RS09080	COG0300	oxidoreductase activity
CF386_RS09090	COG1017	nitric oxide dioxygenase activity
CF386_RS09090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF386_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
CF386_RS09140	COG2807	transmembrane transport
CF386_RS09145	COG2962	Rard protein
CF386_RS09155	COG0583	DNA-binding transcription factor activity
CF386_RS09160	COG0028	Belongs to the TPP enzyme family
CF386_RS09195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CF386_RS09215	COG2814	Major facilitator Superfamily
CF386_RS09220	COG0523	cobalamin synthesis protein
CF386_RS09240	COG0583	DNA-binding transcription factor activity
CF386_RS09275	COG3158	transport of potassium into the cell
CF386_RS09280	COG3158	transport of potassium into the cell
CF386_RS09290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CF386_RS09295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CF386_RS09315	COG2070	2-Nitropropane dioxygenase
CF386_RS09320	COG2070	2-Nitropropane dioxygenase
CF386_RS09330	COG0586	Pfam SNARE associated Golgi protein
CF386_RS09335	COG0534	Mate efflux family protein
CF386_RS09340	COG1609	Transcriptional regulator
CF386_RS09345	COG1309	transcriptional regulator
CF386_RS09405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CF386_RS09415	COG4948	Mandelate Racemase Muconate Lactonizing
CF386_RS09420	COG1304	FMN binding
CF386_RS09480	COG0463	Glycosyl transferase, family 2
CF386_RS09485	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CF386_RS09495	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CF386_RS09505	COG2205	protein histidine kinase activity
CF386_RS09530	COG2814	Major facilitator Superfamily
CF386_RS09535	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CF386_RS09545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CF386_RS09555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF386_RS09565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CF386_RS09590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CF386_RS09590	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CF386_RS09595	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CF386_RS09595	COG2755	lipolytic protein G-D-S-L family
CF386_RS09600	COG0659	secondary active sulfate transmembrane transporter activity
CF386_RS09625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF386_RS09630	COG2873	o-acetylhomoserine
CF386_RS09675	COG3279	Response regulator of the LytR AlgR family
CF386_RS09685	COG0477	Major facilitator Superfamily
CF386_RS09705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CF386_RS09750	COG0673	inositol 2-dehydrogenase activity
CF386_RS09760	COG1741	Belongs to the pirin family
CF386_RS09765	COG0583	DNA-binding transcription factor activity
CF386_RS09775	COG1881	PFAM PEBP family protein
CF386_RS09780	COG0488	(ABC) transporter
CF386_RS09820	COG0514	ATP-dependent DNA helicase (RecQ)
CF386_RS09850	COG2137	regulation of response to DNA damage stimulus
CF386_RS09860	COG0431	NADPH-dependent FMN reductase
CF386_RS09870	COG0492	ferredoxin-NADP+ reductase activity
CF386_RS09875	COG0640	Transcriptional regulator
CF386_RS09900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CF386_RS09905	COG0697	spore germination
CF386_RS09920	COG2207	Transcriptional regulator
CF386_RS09945	COG0583	DNA-binding transcription factor activity
CF386_RS09960	COG1770	oligopeptidase
CF386_RS09965	COG1196	nuclear chromosome segregation
CF386_RS09965	COG0739	heme binding
CF386_RS09965	COG0741	lytic transglycosylase activity
CF386_RS09970	COG2818	Glycosylase
CF386_RS09985	COG1979	alcohol dehydrogenase
CF386_RS10015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF386_RS10040	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CF386_RS10060	COG2815	serine threonine protein kinase
CF386_RS10060	COG0515	serine threonine protein kinase
CF386_RS10105	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CF386_RS10110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CF386_RS10115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CF386_RS10120	COG2855	membrane
CF386_RS10130	COG3477	response to acidic pH
CF386_RS10145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CF386_RS10150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CF386_RS10155	COG0676	glucose-6-phosphate 1-epimerase activity
CF386_RS10195	COG1739	Uncharacterized protein family UPF0029
CF386_RS10220	COG0583	DNA-binding transcription factor activity
CF386_RS10235	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CF386_RS10255	COG1012	belongs to the aldehyde dehydrogenase family
CF386_RS10280	COG0784	Response regulator, receiver
CF386_RS10280	COG2198	Histidine kinase
CF386_RS10280	COG2205	protein histidine kinase activity
CF386_RS10285	COG2197	response regulator
CF386_RS10300	COG1125	glycine betaine transport
CF386_RS10300	COG0517	IMP dehydrogenase activity
CF386_RS10330	COG1181	Belongs to the D-alanine--D-alanine ligase family
CF386_RS10340	COG0813	purine-nucleoside phosphorylase activity
CF386_RS10350	COG0004	ammonium transporteR
CF386_RS10365	COG3477	response to acidic pH
CF386_RS10370	COG0579	oxidoreductase
CF386_RS10380	COG0114	fumarate hydratase activity
CF386_RS10390	COG3784	Protein of unknown function (DUF1318)
CF386_RS10395	COG2207	Transcriptional regulator
CF386_RS10400	COG2814	Major facilitator Superfamily
CF386_RS10420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CF386_RS10435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CF386_RS10440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF386_RS10455	COG1984	allophanate hydrolase subunit 2
CF386_RS10460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF386_RS10480	COG1294	oxidase, subunit
CF386_RS10485	COG1271	oxidase subunit
CF386_RS10490	COG1472	Belongs to the glycosyl hydrolase 3 family
CF386_RS10500	COG0531	amino acid
CF386_RS10510	COG1360	Flagellar Motor Protein
CF386_RS10515	COG0745	RESPONSE REGULATOR receiver
CF386_RS10540	COG2267	carboxylic ester hydrolase activity
CF386_RS10550	COG0583	DNA-binding transcription factor activity
CF386_RS10565	COG2223	nitrite transmembrane transporter activity
CF386_RS10575	COG0626	cystathionine gamma-synthase activity
CF386_RS10580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CF386_RS10585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CF386_RS10600	COG2084	Dehydrogenase
CF386_RS10625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CF386_RS10645	COG2207	Transcriptional regulator
CF386_RS10655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CF386_RS10655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CF386_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
CF386_RS10695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF386_RS10735	COG1121	(ABC) transporter
CF386_RS10740	COG2814	Major facilitator Superfamily
CF386_RS10775	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CF386_RS10790	COG0789	Transcriptional regulator
CF386_RS10800	COG0833	amino acid
CF386_RS10805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF386_RS10805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CF386_RS10835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CF386_RS10850	COG0745	RESPONSE REGULATOR receiver
CF386_RS10860	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CF386_RS10875	COG0737	Belongs to the 5'-nucleotidase family
CF386_RS10900	COG0583	DNA-binding transcription factor activity
CF386_RS10905	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CF386_RS10915	COG0463	Glycosyl transferase, family 2
CF386_RS10920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CF386_RS10940	COG0348	domain, Protein
CF386_RS10945	COG0672	)-iron permease
CF386_RS10955	COG1968	undecaprenyl-diphosphatase activity
CF386_RS10990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CF386_RS11015	COG0415	Belongs to the DNA photolyase family
CF386_RS11020	COG0789	Transcriptional regulator
CF386_RS11035	COG0583	DNA-binding transcription factor activity
CF386_RS11050	COG0069	glutamate synthase activity
CF386_RS11055	COG0659	secondary active sulfate transmembrane transporter activity
CF386_RS11060	COG0531	amino acid
CF386_RS11090	COG1609	Transcriptional regulator
CF386_RS11095	COG0351	phosphomethylpyrimidine kinase
CF386_RS11110	COG0598	Magnesium transport protein CorA
CF386_RS11125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF386_RS11130	COG0583	DNA-binding transcription factor activity
CF386_RS11150	COG1227	inorganic diphosphatase activity
CF386_RS11160	COG3009	Protein conserved in bacteria
CF386_RS11165	COG3008	intermembrane lipid transfer
CF386_RS11170	COG2995	paraquat-inducible protein a
CF386_RS11175	COG1349	DNA-binding transcription factor activity
CF386_RS11185	COG1619	proteins homologs of microcin C7 resistance protein MccF
CF386_RS11190	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CF386_RS11195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CF386_RS11200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF386_RS11200	COG2213	PTS system mannitol-specific
CF386_RS11205	COG0246	Mannitol dehydrogenase
CF386_RS11235	COG2814	Major facilitator Superfamily
CF386_RS11240	COG2814	Major facilitator Superfamily
CF386_RS11255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF386_RS11270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF386_RS11275	COG0826	peptidase U32
CF386_RS11290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CF386_RS11305	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CF386_RS11320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CF386_RS11325	COG0463	Glycosyl transferase, family 2
CF386_RS11360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CF386_RS11365	COG0024	Methionine aminopeptidase
CF386_RS11370	COG0811	peptide transport
CF386_RS11380	COG4206	TonB-dependent receptor
CF386_RS11405	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CF386_RS11445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CF386_RS11450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CF386_RS11465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CF386_RS11500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CF386_RS11510	COG1028	Short-chain dehydrogenase reductase Sdr
CF386_RS11525	COG2989	Protein conserved in bacteria
CF386_RS11585	COG0183	Belongs to the thiolase family
CF386_RS11625	COG3122	Protein conserved in bacteria
CF386_RS11640	COG0248	Ppx GppA phosphatase
CF386_RS11645	COG0248	Ppx GppA phosphatase
CF386_RS11650	COG1609	Transcriptional regulator
CF386_RS11655	COG1393	Belongs to the ArsC family
CF386_RS11660	COG2017	converts alpha-aldose to the beta-anomer
CF386_RS11670	COG1085	galactose-1-phosphate uridylyltransferase
CF386_RS11680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CF386_RS11685	COG0789	Transcriptional regulator
CF386_RS11690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CF386_RS11695	COG3961	Belongs to the TPP enzyme family
CF386_RS11700	COG4085	toxin activity
CF386_RS11700	COG0737	Belongs to the 5'-nucleotidase family
CF386_RS11700	COG1525	nuclease
CF386_RS11725	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CF386_RS11725	COG0506	proline dehydrogenase activity
CF386_RS11725	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CF386_RS11735	COG1444	tRNA N-acetyltransferase activity
CF386_RS11790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF386_RS11795	COG1278	Cold shock
CF386_RS11830	COG1322	Protein conserved in bacteria
CF386_RS11840	COG0477	Major facilitator Superfamily
CF386_RS11855	COG0791	NLP P60 protein
CF386_RS11860	COG1132	(ABC) transporter
CF386_RS11875	COG1607	acyl-coa hydrolase
CF386_RS11895	COG0686	Belongs to the AlaDH PNT family
CF386_RS11900	COG3104	oligopeptide transport
CF386_RS11905	COG1742	UPF0060 membrane protein
CF386_RS11925	COG4166	transmembrane transport
CF386_RS11930	COG4166	transmembrane transport
CF386_RS11975	COG0477	Major facilitator Superfamily
CF386_RS11985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CF386_RS11990	COG2095	MarC family integral membrane protein
CF386_RS11995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CF386_RS12000	COG2807	transmembrane transport
CF386_RS12010	COG1214	PFAM Peptidase M22, glycoprotease
CF386_RS12010	COG0456	acetyltransferase
CF386_RS12030	COG0352	thiamine-phosphate diphosphorylase activity
CF386_RS12035	COG1271	oxidase subunit
CF386_RS12050	COG2249	NAD(P)H dehydrogenase (quinone) activity
CF386_RS12065	COG2119	membrane
CF386_RS12080	COG1192	Involved in chromosome partitioning
CF386_RS12095	COG1022	Amp-dependent synthetase and ligase
CF386_RS12105	COG2261	transglycosylase associated protein
CF386_RS12110	COG1295	ribonuclease BN
CF386_RS12120	COG0513	Belongs to the DEAD box helicase family
CF386_RS12130	COG1376	ErfK ybiS ycfS ynhG family protein
CF386_RS12130	COG1388	LysM domain
CF386_RS12155	COG1999	signal sequence binding
CF386_RS12175	COG1686	Belongs to the peptidase S11 family
CF386_RS12180	COG4251	negative regulation of phosphorylation
CF386_RS12180	COG2203	Gaf domain
CF386_RS12180	COG5001	Diguanylate cyclase
CF386_RS12180	COG3706	GGDEF domain
CF386_RS12190	COG0312	modulator of DNA gyrase
CF386_RS12200	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CF386_RS12235	COG1067	ATP-dependent peptidase activity
CF386_RS12240	COG0583	DNA-binding transcription factor activity
CF386_RS12245	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CF386_RS12255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF386_RS12265	COG0681	Belongs to the peptidase S26 family
CF386_RS12280	COG0681	Belongs to the peptidase S26 family
CF386_RS12285	COG0681	Belongs to the peptidase S26 family
CF386_RS12290	COG3133	Outer membrane lipoprotein
CF386_RS12295	COG0583	DNA-binding transcription factor activity
CF386_RS12305	COG1560	Kdo2-lipid A biosynthetic process
CF386_RS12315	COG1028	Short-chain dehydrogenase reductase Sdr
CF386_RS12335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CF386_RS12370	COG3838	Conjugal transfer protein Trbc
CF386_RS12380	COG3451	type IV secretory pathway VirB4
CF386_RS12385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CF386_RS12415	COG4962	Type ii secretion system protein e
CF386_RS12420	COG0442	prolyl-tRNA aminoacylation
CF386_RS12425	COG0738	Major facilitator superfamily
CF386_RS12445	COG2431	L-lysine efflux transmembrane transporter activity
CF386_RS12465	COG0516	GMP reductase activity
CF386_RS12470	COG0330	HflC and HflK could
CF386_RS12475	COG1585	Membrane protein implicated in regulation of membrane protease activity
CF386_RS12480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CF386_RS12485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CF386_RS12495	COG0583	DNA-binding transcription factor activity
CF386_RS12500	COG0400	carboxylic ester hydrolase activity
CF386_RS12505	COG0583	DNA-binding transcription factor activity
CF386_RS12530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF386_RS12530	COG0678	peroxiredoxin activity
CF386_RS12540	COG0583	DNA-binding transcription factor activity
CF386_RS12545	COG0123	including yeast histone deacetylase and acetoin utilization protein
CF386_RS12560	COG1671	Belongs to the UPF0178 family
CF386_RS12580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CF386_RS12600	COG0352	thiamine-phosphate diphosphorylase activity