locus-tag	class	description
C5Q97_RS00040	COG3250	beta-galactosidase activity
C5Q97_RS00050	COG1609	Transcriptional regulator
C5Q97_RS00115	COG0110	maltose O-acetyltransferase activity
C5Q97_RS00135	COG1609	Transcriptional regulator
C5Q97_RS00165	COG3209	COG3209 Rhs family protein
C5Q97_RS00170	COG3209	COG3209 Rhs family protein
C5Q97_RS00215	COG2226	methyltransferase
C5Q97_RS00225	COG0438	transferase activity, transferring glycosyl groups
C5Q97_RS00355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5Q97_RS00365	COG0444	Belongs to the ABC transporter superfamily
C5Q97_RS00370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5Q97_RS00375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5Q97_RS00395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5Q97_RS00400	COG0546	phosphoglycolate phosphatase activity
C5Q97_RS00415	COG0617	tRNA 3'-terminal CCA addition
C5Q97_RS00425	COG4399	Belongs to the UPF0754 family
C5Q97_RS00470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5Q97_RS00485	COG1069	ribulokinase activity
C5Q97_RS00495	COG2160	L-arabinose isomerase activity
C5Q97_RS00500	COG1312	Catalyzes the dehydration of D-mannonate
C5Q97_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS00525	COG0584	glycerophosphoryl diester phosphodiesterase
C5Q97_RS00530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5Q97_RS00540	COG0606	chelatase, subunit chli
C5Q97_RS00550	COG0742	ribosomal rna small subunit methyltransferase
C5Q97_RS00555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5Q97_RS00555	COG0519	Catalyzes the synthesis of GMP from XMP
C5Q97_RS00565	COG2264	protein methyltransferase activity
C5Q97_RS00575	COG0445	tRNA wobble uridine modification
C5Q97_RS00580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5Q97_RS00605	COG1131	(ABC) transporter
C5Q97_RS00620	COG1253	flavin adenine dinucleotide binding
C5Q97_RS00625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5Q97_RS00630	COG3250	beta-galactosidase activity
C5Q97_RS00635	COG1126	abc transporter atp-binding protein
C5Q97_RS00640	COG0765	amino acid transport
C5Q97_RS00645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Q97_RS00660	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS00700	COG0242	peptide deformylase activity
C5Q97_RS00720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5Q97_RS00775	COG0738	Major facilitator superfamily
C5Q97_RS00800	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS00820	COG2165	general secretion pathway protein
C5Q97_RS00830	COG1609	Transcriptional regulator
C5Q97_RS00850	COG1609	Transcriptional regulator
C5Q97_RS00880	COG1609	Transcriptional regulator
C5Q97_RS00885	COG1573	uracil-dna glycosylase
C5Q97_RS00895	COG0137	argininosuccinate synthase activity
C5Q97_RS00900	COG0473	3-isopropylmalate dehydrogenase activity
C5Q97_RS00910	COG0095	Lipoate-protein ligase
C5Q97_RS00915	COG0571	ribonuclease III activity
C5Q97_RS00920	COG1454	alcohol dehydrogenase
C5Q97_RS00955	COG1609	Transcriptional regulator
C5Q97_RS01015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5Q97_RS01015	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5Q97_RS01015	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5Q97_RS01015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5Q97_RS01020	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS01025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5Q97_RS01050	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5Q97_RS01055	COG1283	sodium-dependent phosphate transmembrane transporter activity
C5Q97_RS01065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5Q97_RS01065	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5Q97_RS01070	COG1388	LysM domain
C5Q97_RS01070	COG3409	Peptidoglycan-binding domain 1 protein
C5Q97_RS01070	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5Q97_RS01085	COG2176	DNA-directed DNA polymerase activity
C5Q97_RS01115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5Q97_RS01115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5Q97_RS01230	COG1486	melibiose metabolic process
C5Q97_RS01255	COG3458	cephalosporin-C deacetylase activity
C5Q97_RS01320	COG0582	viral genome integration into host DNA
C5Q97_RS01340	COG0456	acetyltransferase
C5Q97_RS01340	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C5Q97_RS01350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5Q97_RS01370	COG0745	RESPONSE REGULATOR receiver
C5Q97_RS01375	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C5Q97_RS01380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C5Q97_RS01385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5Q97_RS01395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5Q97_RS01395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5Q97_RS01400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5Q97_RS01410	COG2264	protein methyltransferase activity
C5Q97_RS01415	COG3264	Mechanosensitive ion channel
C5Q97_RS01415	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C5Q97_RS01430	COG1609	Transcriptional regulator
C5Q97_RS01470	COG0028	Belongs to the TPP enzyme family
C5Q97_RS01480	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5Q97_RS01500	COG1609	Transcriptional regulator
C5Q97_RS01515	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C5Q97_RS01535	COG1609	Transcriptional regulator
C5Q97_RS01545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5Q97_RS01550	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5Q97_RS01565	COG2207	Transcriptional regulator
C5Q97_RS01575	COG0489	protein tyrosine kinase activity
C5Q97_RS01585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5Q97_RS01600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C5Q97_RS01605	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C5Q97_RS01610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C5Q97_RS01615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5Q97_RS01615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C5Q97_RS01625	COG2738	Putative neutral zinc metallopeptidase
C5Q97_RS01640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5Q97_RS01645	COG1295	ribonuclease BN
C5Q97_RS01735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5Q97_RS01775	COG3177	Filamentation induced by cAMP protein fic
C5Q97_RS01830	COG1321	iron dependent repressor
C5Q97_RS01835	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C5Q97_RS01835	COG1918	ferrous iron import across plasma membrane
C5Q97_RS01840	COG1418	mRNA catabolic process
C5Q97_RS01885	COG2165	general secretion pathway protein
C5Q97_RS01895	COG3250	beta-galactosidase activity
C5Q97_RS01905	COG2723	6-phospho-beta-galactosidase activity
C5Q97_RS02100	COG0582	viral genome integration into host DNA
C5Q97_RS02110	COG2801	Transposase and inactivated derivatives
C5Q97_RS02150	COG0668	transmembrane transport
C5Q97_RS02160	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C5Q97_RS02175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5Q97_RS02185	COG0513	Belongs to the DEAD box helicase family
C5Q97_RS02190	COG1509	lysine 2,3-aminomutase activity
C5Q97_RS02205	COG0535	radical SAM domain protein
C5Q97_RS02220	COG1823	symporter activity
C5Q97_RS02245	COG2165	general secretion pathway protein
C5Q97_RS02320	COG2268	Band 7 protein
C5Q97_RS02330	COG4993	Dehydrogenase
C5Q97_RS02335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5Q97_RS02345	COG0463	Glycosyl transferase, family 2
C5Q97_RS02355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5Q97_RS02370	COG1720	tRNA m6t6A37 methyltransferase activity
C5Q97_RS02385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5Q97_RS02420	COG1671	Belongs to the UPF0178 family
C5Q97_RS02440	COG2033	superoxide reductase activity
C5Q97_RS02480	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C5Q97_RS02490	COG0659	secondary active sulfate transmembrane transporter activity
C5Q97_RS02500	COG1194	a g-specific adenine glycosylase
C5Q97_RS02505	COG0352	thiamine-phosphate diphosphorylase activity
C5Q97_RS02520	COG1609	Transcriptional regulator
C5Q97_RS02525	COG2165	general secretion pathway protein
C5Q97_RS02555	COG0667	Aldo Keto reductase
C5Q97_RS02570	COG2194	sulfuric ester hydrolase activity
C5Q97_RS02585	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C5Q97_RS02610	COG0107	imidazoleglycerol-phosphate synthase activity
C5Q97_RS02615	COG1410	methionine synthase
C5Q97_RS02615	COG0646	methionine synthase
C5Q97_RS02630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C5Q97_RS02640	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C5Q97_RS02655	COG0254	rRNA binding
C5Q97_RS02680	COG3040	lipid binding
C5Q97_RS02695	COG1234	tRNA 3'-trailer cleavage
C5Q97_RS02700	COG5002	protein histidine kinase activity
C5Q97_RS02725	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C5Q97_RS02755	COG1595	DNA-templated transcription, initiation
C5Q97_RS02760	COG0657	acetylesterase activity
C5Q97_RS02810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5Q97_RS02815	COG0793	Belongs to the peptidase S41A family
C5Q97_RS02820	COG0366	Alpha amylase catalytic
C5Q97_RS02825	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C5Q97_RS02835	COG0534	Mate efflux family protein
C5Q97_RS02840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5Q97_RS02855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5Q97_RS02870	COG0800	Aldolase
C5Q97_RS02910	COG0564	pseudouridine synthase activity
C5Q97_RS02925	COG1968	undecaprenyl-diphosphatase activity
C5Q97_RS02930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5Q97_RS02980	COG3266	domain, Protein
C5Q97_RS02980	COG0515	serine threonine protein kinase
C5Q97_RS03035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C5Q97_RS03040	COG3177	Filamentation induced by cAMP protein fic
C5Q97_RS03070	COG3586	endonuclease activity
C5Q97_RS03150	COG2801	Transposase and inactivated derivatives
C5Q97_RS03250	COG2165	general secretion pathway protein
C5Q97_RS03280	COG2198	Histidine kinase
C5Q97_RS03280	COG5002	protein histidine kinase activity
C5Q97_RS03280	COG0784	Response regulator, receiver
C5Q97_RS03310	COG1450	Type ii and iii secretion system protein
C5Q97_RS03315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5Q97_RS03320	COG1459	type II secretion system
C5Q97_RS03325	COG2165	general secretion pathway protein
C5Q97_RS03370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C5Q97_RS03380	COG1609	Transcriptional regulator
C5Q97_RS03425	COG1609	Transcriptional regulator
C5Q97_RS03445	COG2211	Major facilitator Superfamily
C5Q97_RS03455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5Q97_RS03460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5Q97_RS03465	COG0525	valine-tRNA ligase activity
C5Q97_RS03520	COG2076	Multidrug Resistance protein
C5Q97_RS03525	COG4452	Inner membrane protein CreD
C5Q97_RS03545	COG1393	Belongs to the ArsC family
C5Q97_RS03550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5Q97_RS03570	COG2304	oxidoreductase activity
C5Q97_RS03580	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C5Q97_RS03610	COG3458	cephalosporin-C deacetylase activity
C5Q97_RS03635	COG0656	L-ascorbic acid biosynthetic process
C5Q97_RS03640	COG1609	Transcriptional regulator
C5Q97_RS03670	COG1408	metallophosphoesterase
C5Q97_RS03675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5Q97_RS03690	COG0756	dUTP diphosphatase activity
C5Q97_RS03705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5Q97_RS03725	COG1695	Transcriptional regulator
C5Q97_RS03765	COG1609	Transcriptional regulator
C5Q97_RS03805	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS03810	COG0604	alcohol dehydrogenase
C5Q97_RS03820	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS03850	COG1609	Transcriptional regulator
C5Q97_RS03855	COG3876	Protein conserved in bacteria
C5Q97_RS03875	COG1609	Transcriptional regulator
C5Q97_RS03880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Q97_RS03880	COG2205	protein histidine kinase activity
C5Q97_RS03885	COG1272	protein, Hemolysin III
C5Q97_RS03895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5Q97_RS03915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C5Q97_RS03920	COG4806	L-rhamnose isomerase
C5Q97_RS03925	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS03940	COG1490	D-aminoacyl-tRNA deacylase activity
C5Q97_RS03945	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5Q97_RS03955	COG0750	zinc metalloprotease
C5Q97_RS03960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5Q97_RS03970	COG2942	2-epimerase
C5Q97_RS03980	COG2001	Belongs to the MraZ family
C5Q97_RS04020	COG1335	isochorismatase
C5Q97_RS04030	COG5002	protein histidine kinase activity
C5Q97_RS04035	COG0745	RESPONSE REGULATOR receiver
C5Q97_RS04040	COG0215	cysteine-tRNA ligase activity
C5Q97_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS04120	COG2226	methyltransferase
C5Q97_RS04190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5Q97_RS04240	COG1061	Type III restriction enzyme res subunit
C5Q97_RS04295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5Q97_RS04300	COG0270	DNA (cytosine-5-)-methyltransferase activity
C5Q97_RS04525	COG3727	T/G mismatch-specific endonuclease activity
C5Q97_RS04585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5Q97_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS04655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5Q97_RS04660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5Q97_RS04760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5Q97_RS04770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5Q97_RS04810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5Q97_RS04850	COG1959	2 iron, 2 sulfur cluster binding
C5Q97_RS04865	COG1151	hydroxylamine reductase activity
C5Q97_RS04875	COG0534	Mate efflux family protein
C5Q97_RS04890	COG1283	sodium-dependent phosphate transmembrane transporter activity
C5Q97_RS04895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5Q97_RS04895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5Q97_RS04920	COG0697	spore germination
C5Q97_RS04925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5Q97_RS04950	COG2165	general secretion pathway protein
C5Q97_RS04960	COG0066	3-isopropylmalate dehydratase activity
C5Q97_RS04970	COG1396	sequence-specific DNA binding
C5Q97_RS05010	COG1609	Transcriptional regulator
C5Q97_RS05090	COG1131	(ABC) transporter
C5Q97_RS05100	COG0714	Associated with various cellular activities
C5Q97_RS05125	COG1217	gtp-binding protein TYPA
C5Q97_RS05170	COG1011	Hydrolase
C5Q97_RS05200	COG0488	(ABC) transporter
C5Q97_RS05210	COG0535	radical SAM domain protein
C5Q97_RS05215	COG0509	glycine decarboxylation via glycine cleavage system
C5Q97_RS05225	COG0586	Pfam SNARE associated Golgi protein
C5Q97_RS05240	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C5Q97_RS05260	COG2801	Transposase and inactivated derivatives
C5Q97_RS05315	COG0110	maltose O-acetyltransferase activity
C5Q97_RS05340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5Q97_RS05345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5Q97_RS05350	COG0483	inositol monophosphate 1-phosphatase activity
C5Q97_RS05430	COG0647	UMP catabolic process
C5Q97_RS05450	COG0584	glycerophosphoryl diester phosphodiesterase
C5Q97_RS05455	COG0420	3'-5' exonuclease activity
C5Q97_RS05460	COG0419	ATPase involved in DNA repair
C5Q97_RS05465	COG0383	alpha-mannosidase activity
C5Q97_RS05475	COG0590	tRNA wobble adenosine to inosine editing
C5Q97_RS05485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5Q97_RS05495	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5Q97_RS05565	COG2207	Transcriptional regulator
C5Q97_RS05570	COG0445	tRNA wobble uridine modification
C5Q97_RS05575	COG1609	Transcriptional regulator
C5Q97_RS05625	COG1414	Transcriptional regulator
C5Q97_RS05630	COG1882	Formate acetyltransferase
C5Q97_RS05635	COG1882	Formate acetyltransferase
C5Q97_RS05650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5Q97_RS05675	COG2188	Transcriptional regulator
C5Q97_RS05710	COG0297	glycogen (starch) synthase activity
C5Q97_RS05715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5Q97_RS05735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5Q97_RS05745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5Q97_RS05750	COG0733	neurotransmitter:sodium symporter activity
C5Q97_RS05755	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS05770	COG1408	metallophosphoesterase
C5Q97_RS05775	COG1032	radical SAM domain protein
C5Q97_RS05835	COG0758	DNA mediated transformation
C5Q97_RS05840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5Q97_RS05855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5Q97_RS05875	COG1525	nuclease
C5Q97_RS05885	COG1132	(ABC) transporter
C5Q97_RS05920	COG0641	radical SAM
C5Q97_RS05940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5Q97_RS05960	COG0358	DNA primase activity
C5Q97_RS05970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5Q97_RS05975	COG1121	(ABC) transporter
C5Q97_RS06020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5Q97_RS06025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5Q97_RS06040	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C5Q97_RS06040	COG0517	IMP dehydrogenase activity
C5Q97_RS06045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5Q97_RS06050	COG0140	phosphoribosyl-ATP diphosphatase activity
C5Q97_RS06060	COG2949	membrane
C5Q97_RS06120	COG0587	DNA-directed DNA polymerase activity
C5Q97_RS06135	COG1682	transport, permease protein
C5Q97_RS06170	COG1609	Transcriptional regulator
C5Q97_RS06215	COG0395	ABC-type sugar transport system, permease component
C5Q97_RS06235	COG0246	Mannitol dehydrogenase
C5Q97_RS06240	COG2721	sulfolactate sulfo-lyase activity
C5Q97_RS06250	COG0268	Binds directly to 16S ribosomal RNA
C5Q97_RS06265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5Q97_RS06270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5Q97_RS06280	COG1216	Glycosyl transferase, family 2
C5Q97_RS06315	COG3408	Glycogen debranching enzyme
C5Q97_RS06320	COG1917	Cupin 2, conserved barrel domain protein
C5Q97_RS06320	COG2207	Transcriptional regulator
C5Q97_RS06335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C5Q97_RS06340	COG1074	ATP-dependent DNA helicase activity
C5Q97_RS06345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5Q97_RS06365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5Q97_RS06370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5Q97_RS06390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5Q97_RS06420	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C5Q97_RS06510	COG1045	serine acetyltransferase
C5Q97_RS06525	COG2244	polysaccharide biosynthetic process
C5Q97_RS06530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5Q97_RS06535	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C5Q97_RS06565	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C5Q97_RS06565	COG3408	Glycogen debranching enzyme
C5Q97_RS06580	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5Q97_RS06585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5Q97_RS06595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5Q97_RS06605	COG5492	domain, Protein
C5Q97_RS06630	COG0165	Argininosuccinate lyase
C5Q97_RS06635	COG0052	Belongs to the universal ribosomal protein uS2 family
C5Q97_RS06640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5Q97_RS06680	COG0514	ATP-dependent DNA helicase (RecQ)
C5Q97_RS06710	COG0110	maltose O-acetyltransferase activity
C5Q97_RS06720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5Q97_RS06735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5Q97_RS06755	COG0859	PFAM glycosyl transferase family 9
C5Q97_RS06760	COG1077	Cell shape determining protein MreB Mrl
C5Q97_RS06785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5Q97_RS06795	COG1205	dead DEAH box helicase
C5Q97_RS06795	COG1111	helicase
C5Q97_RS06830	COG2165	general secretion pathway protein
C5Q97_RS06890	COG2188	Transcriptional regulator
C5Q97_RS06905	COG2205	protein histidine kinase activity
C5Q97_RS06910	COG5002	protein histidine kinase activity
C5Q97_RS06915	COG2204	response regulator
C5Q97_RS07185	COG0632	four-way junction helicase activity
C5Q97_RS07200	COG0006	proline dipeptidase activity
C5Q97_RS07205	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C5Q97_RS07215	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5Q97_RS07220	COG1196	nuclear chromosome segregation
C5Q97_RS07225	COG0326	Molecular chaperone. Has ATPase activity
C5Q97_RS07235	COG1388	LysM domain
C5Q97_RS07235	COG3409	Peptidoglycan-binding domain 1 protein
C5Q97_RS07235	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5Q97_RS07245	COG4106	trans-aconitate 2-methyltransferase activity
C5Q97_RS07265	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS07300	COG0724	RNA recognition motif
C5Q97_RS07310	COG1355	regulation of microtubule-based process
C5Q97_RS07315	COG1605	Chorismate mutase
C5Q97_RS07315	COG0077	Prephenate dehydratase
C5Q97_RS07325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5Q97_RS07330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5Q97_RS07365	COG2207	Transcriptional regulator
C5Q97_RS07385	COG0531	amino acid
C5Q97_RS07390	COG0724	RNA recognition motif
C5Q97_RS07400	COG1285	pathogenesis
C5Q97_RS07415	COG0436	Aminotransferase
C5Q97_RS07425	COG0459	protein refolding
C5Q97_RS07430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C5Q97_RS07435	COG0443	Heat shock 70 kDa protein
C5Q97_RS07440	COG3118	belongs to the thioredoxin family
C5Q97_RS07450	COG0602	queuosine metabolic process
C5Q97_RS07465	COG4221	oxidoreductase activity
C5Q97_RS07470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5Q97_RS07475	COG1917	Cupin 2, conserved barrel domain protein
C5Q97_RS07475	COG4977	sequence-specific DNA binding
C5Q97_RS07480	COG1643	Atp-dependent helicase
C5Q97_RS07485	COG4977	sequence-specific DNA binding
C5Q97_RS07515	COG4948	Mandelate Racemase Muconate Lactonizing
C5Q97_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS07545	COG2207	Transcriptional regulator
C5Q97_RS07560	COG4145	pantothenate transmembrane transporter activity
C5Q97_RS07565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C5Q97_RS07580	COG1966	Carbon starvation protein
C5Q97_RS07585	COG0519	Catalyzes the synthesis of GMP from XMP
C5Q97_RS07585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5Q97_RS07615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5Q97_RS07625	COG4608	Belongs to the ABC transporter superfamily
C5Q97_RS07635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5Q97_RS07640	COG0601	transmembrane transport
C5Q97_RS07660	COG2188	Transcriptional regulator
C5Q97_RS07685	COG1609	Transcriptional regulator
C5Q97_RS07695	COG0395	ABC-type sugar transport system, permease component
C5Q97_RS07700	COG1175	transmembrane transport
C5Q97_RS07720	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C5Q97_RS07730	COG1305	Transglutaminase-like
C5Q97_RS07760	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C5Q97_RS07760	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C5Q97_RS07770	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C5Q97_RS07785	COG3250	beta-galactosidase activity
C5Q97_RS07790	COG2081	HI0933 family
C5Q97_RS07815	COG2165	general secretion pathway protein
C5Q97_RS07830	COG3875	lactate racemase activity
C5Q97_RS07835	COG2086	electron transfer activity
C5Q97_RS07840	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5Q97_RS07845	COG0277	FAD linked oxidase domain protein
C5Q97_RS07855	COG0662	Cupin 2, conserved barrel domain protein
C5Q97_RS07855	COG2207	Transcriptional regulator
C5Q97_RS07860	COG0366	Alpha amylase catalytic
C5Q97_RS07885	COG3250	beta-galactosidase activity
C5Q97_RS07890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5Q97_RS07905	COG1151	hydroxylamine reductase activity
C5Q97_RS07920	COG3401	FG-GAP repeat protein
C5Q97_RS07925	COG1609	Transcriptional regulator
C5Q97_RS07935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C5Q97_RS07940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5Q97_RS07950	COG1609	Transcriptional regulator
C5Q97_RS07970	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C5Q97_RS07975	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5Q97_RS07980	COG0601	transmembrane transport
C5Q97_RS07990	COG0826	peptidase U32
C5Q97_RS07995	COG0714	Associated with various cellular activities
C5Q97_RS08005	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5Q97_RS08050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5Q97_RS08075	COG0800	Aldolase
C5Q97_RS08095	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C5Q97_RS08140	COG0534	Mate efflux family protein
C5Q97_RS08165	COG1609	Transcriptional regulator
C5Q97_RS08195	COG0047	phosphoribosylformylglycinamidine synthase activity
C5Q97_RS08200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C5Q97_RS08205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C5Q97_RS08215	COG0012	GTP binding
C5Q97_RS08225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5Q97_RS08230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5Q97_RS08230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5Q97_RS08250	COG1609	Transcriptional regulator
C5Q97_RS08265	COG0788	formyltetrahydrofolate deformylase activity
C5Q97_RS08295	COG1609	Transcriptional regulator
C5Q97_RS08335	COG1477	protein flavinylation
C5Q97_RS08340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5Q97_RS08345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5Q97_RS08355	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5Q97_RS08380	COG0802	atpase or kinase
C5Q97_RS08385	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C5Q97_RS08390	COG0367	asparagine synthase
C5Q97_RS08395	COG3118	belongs to the thioredoxin family
C5Q97_RS08395	COG0492	ferredoxin-NADP+ reductase activity
C5Q97_RS08425	COG1063	alcohol dehydrogenase
C5Q97_RS08445	COG1609	Transcriptional regulator
C5Q97_RS08455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5Q97_RS08455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5Q97_RS08470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5Q97_RS08475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5Q97_RS08485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5Q97_RS08505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C5Q97_RS08510	COG0129	dihydroxy-acid dehydratase activity
C5Q97_RS08515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5Q97_RS08525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5Q97_RS08530	COG1127	ABC transporter
C5Q97_RS08600	COG4977	sequence-specific DNA binding
C5Q97_RS08600	COG1917	Cupin 2, conserved barrel domain protein
C5Q97_RS08615	COG1609	Transcriptional regulator
C5Q97_RS08665	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS08670	COG1063	alcohol dehydrogenase
C5Q97_RS08675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5Q97_RS08675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5Q97_RS08780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5Q97_RS08800	COG1136	(ABC) transporter
C5Q97_RS08800	COG0577	efflux transmembrane transporter activity
C5Q97_RS08805	COG1136	(ABC) transporter
C5Q97_RS08850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5Q97_RS08865	COG1247	-acetyltransferase
C5Q97_RS08875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C5Q97_RS08885	COG1012	belongs to the aldehyde dehydrogenase family
C5Q97_RS08885	COG1454	alcohol dehydrogenase
C5Q97_RS08890	COG2755	lipolytic protein G-D-S-L family
C5Q97_RS08895	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C5Q97_RS08900	COG0463	Glycosyl transferase, family 2
C5Q97_RS08905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5Q97_RS08905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5Q97_RS08920	COG1063	alcohol dehydrogenase
C5Q97_RS08930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5Q97_RS08935	COG0037	tRNA processing
C5Q97_RS08975	COG1609	Transcriptional regulator
C5Q97_RS08985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5Q97_RS08990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5Q97_RS08995	COG1971	Probably functions as a manganese efflux pump
C5Q97_RS09000	COG0681	Belongs to the peptidase S26 family
C5Q97_RS09015	COG0432	Pfam Uncharacterised protein family UPF0047
C5Q97_RS09030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5Q97_RS09045	COG1132	(ABC) transporter
C5Q97_RS09055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5Q97_RS09075	COG1847	R3H domain protein
C5Q97_RS09080	COG0706	membrane insertase activity
C5Q97_RS09085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5Q97_RS09090	COG0594	ribonuclease P activity
C5Q97_RS09125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5Q97_RS09140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5Q97_RS09150	COG2186	Transcriptional regulator
C5Q97_RS09170	COG3664	PFAM glycoside hydrolase family 39
C5Q97_RS09180	COG1609	Transcriptional regulator
C5Q97_RS09200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5Q97_RS09215	COG0488	(ABC) transporter
C5Q97_RS09255	COG1902	pentaerythritol trinitrate reductase activity
C5Q97_RS09255	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5Q97_RS09260	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C5Q97_RS09310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5Q97_RS09345	COG1486	melibiose metabolic process
C5Q97_RS09350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5Q97_RS09365	COG1609	Transcriptional regulator
C5Q97_RS09385	COG0402	S-adenosylhomocysteine deaminase activity
C5Q97_RS09395	COG1609	Transcriptional regulator
C5Q97_RS09425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5Q97_RS09435	COG0481	GTPase activity
C5Q97_RS09440	COG0681	Belongs to the peptidase S26 family
C5Q97_RS09455	COG0427	acetyl-CoA hydrolase
C5Q97_RS09460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5Q97_RS09465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C5Q97_RS09470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5Q97_RS09485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5Q97_RS09495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5Q97_RS09495	COG0574	Belongs to the PEP-utilizing enzyme family
C5Q97_RS09575	COG5434	Belongs to the glycosyl hydrolase 28 family
C5Q97_RS09585	COG0445	tRNA wobble uridine modification
C5Q97_RS09590	COG2207	Transcriptional regulator
C5Q97_RS09630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C5Q97_RS09650	COG1609	Transcriptional regulator
C5Q97_RS09670	COG2207	Transcriptional regulator
C5Q97_RS09670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5Q97_RS09690	COG0527	aspartate kinase activity
C5Q97_RS09695	COG0428	transporter
C5Q97_RS09700	COG0442	prolyl-tRNA aminoacylation
C5Q97_RS09710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5Q97_RS09735	COG1882	Formate acetyltransferase
C5Q97_RS09750	COG0733	neurotransmitter:sodium symporter activity
C5Q97_RS09760	COG2706	6-phosphogluconolactonase activity
C5Q97_RS09770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5Q97_RS09795	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C5Q97_RS09805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5Q97_RS09810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C5Q97_RS09820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5Q97_RS09825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C5Q97_RS09830	COG0371	Dehydrogenase
C5Q97_RS09835	COG3408	Glycogen debranching enzyme
C5Q97_RS09840	COG4977	sequence-specific DNA binding
C5Q97_RS09870	COG2188	Transcriptional regulator
C5Q97_RS09875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5Q97_RS09925	COG0584	glycerophosphoryl diester phosphodiesterase
C5Q97_RS09935	COG0475	glutathione-regulated potassium exporter activity
C5Q97_RS09950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5Q97_RS09960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5Q97_RS09985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C5Q97_RS10030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5Q97_RS10045	COG0028	Belongs to the TPP enzyme family
C5Q97_RS10060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5Q97_RS10080	COG0438	transferase activity, transferring glycosyl groups
C5Q97_RS10135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5Q97_RS10140	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C5Q97_RS10150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C5Q97_RS10240	COG3458	cephalosporin-C deacetylase activity
C5Q97_RS10245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5Q97_RS10250	COG4106	trans-aconitate 2-methyltransferase activity
C5Q97_RS10260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5Q97_RS10280	COG0028	Belongs to the TPP enzyme family
C5Q97_RS10285	COG0546	phosphoglycolate phosphatase activity
C5Q97_RS10290	COG0463	Glycosyl transferase, family 2
C5Q97_RS10300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5Q97_RS10305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5Q97_RS10310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C5Q97_RS10330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5Q97_RS10340	COG1136	(ABC) transporter
C5Q97_RS10345	COG2270	Major facilitator Superfamily
C5Q97_RS10350	COG0601	transmembrane transport
C5Q97_RS10410	COG2188	Transcriptional regulator
C5Q97_RS10420	COG0497	DNA recombination
C5Q97_RS10445	COG0318	PFAM AMP-dependent synthetase and ligase
C5Q97_RS10445	COG0204	Acyl-transferase
C5Q97_RS10450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5Q97_RS10455	COG1940	carbohydrate kinase activity
C5Q97_RS10460	COG1940	carbohydrate kinase activity
C5Q97_RS10515	COG0676	glucose-6-phosphate 1-epimerase activity
C5Q97_RS10530	COG0107	imidazoleglycerol-phosphate synthase activity
C5Q97_RS10535	COG0281	malic enzyme
C5Q97_RS10535	COG0280	phosphate acetyltransferase
C5Q97_RS10545	COG3250	beta-galactosidase activity
C5Q97_RS10565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5Q97_RS10570	COG0662	Cupin 2, conserved barrel domain protein
C5Q97_RS10570	COG2207	Transcriptional regulator
C5Q97_RS10585	COG0582	viral genome integration into host DNA
C5Q97_RS10690	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C5Q97_RS10690	COG4124	Belongs to the glycosyl hydrolase 26 family
C5Q97_RS10700	COG0440	acetolactate synthase activity
C5Q97_RS10740	COG0445	tRNA wobble uridine modification
C5Q97_RS10755	COG1595	DNA-templated transcription, initiation
C5Q97_RS10760	COG0494	nUDIX hydrolase
C5Q97_RS10770	COG1609	Transcriptional regulator
C5Q97_RS10790	COG2188	Transcriptional regulator
C5Q97_RS10860	COG1368	sulfuric ester hydrolase activity
C5Q97_RS10865	COG3963	phosphatidate phosphatase activity
C5Q97_RS10875	COG3976	FMN-binding domain protein
C5Q97_RS10875	COG1053	succinate dehydrogenase
C5Q97_RS10890	COG0842	Transport permease protein
C5Q97_RS10895	COG0842	Transport permease protein
C5Q97_RS10900	COG1131	(ABC) transporter
C5Q97_RS10910	COG1774	PSP1 C-terminal conserved region
C5Q97_RS10935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5Q97_RS10945	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS10950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5Q97_RS10955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5Q97_RS10995	COG1609	Transcriptional regulator
C5Q97_RS11010	COG1609	Transcriptional regulator
C5Q97_RS11040	COG2853	Lipoprotein
C5Q97_RS11050	COG3940	Belongs to the glycosyl hydrolase 43 family
C5Q97_RS11060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5Q97_RS11065	COG0463	Glycosyl transferase, family 2
C5Q97_RS11070	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5Q97_RS11080	COG3956	TIGRFAM MazG family protein
C5Q97_RS11085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5Q97_RS11090	COG0305	Participates in initiation and elongation during chromosome replication
C5Q97_RS11095	COG0359	binds to the 23S rRNA
C5Q97_RS11100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5Q97_RS11105	COG0629	single-stranded DNA binding
C5Q97_RS11110	COG0360	Binds together with S18 to 16S ribosomal RNA
C5Q97_RS11115	COG0193	aminoacyl-tRNA hydrolase activity
C5Q97_RS11120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5Q97_RS11125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5Q97_RS11145	COG0217	transcriptional regulatory protein
C5Q97_RS11160	COG1486	melibiose metabolic process
C5Q97_RS11180	COG0662	Cupin 2, conserved barrel domain protein
C5Q97_RS11185	COG0019	diaminopimelate decarboxylase activity
C5Q97_RS11200	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5Q97_RS11210	COG0018	arginyl-trna synthetase
C5Q97_RS11215	COG1482	cell wall glycoprotein biosynthetic process
C5Q97_RS11220	COG0824	Thioesterase
C5Q97_RS11235	COG0200	Binds to the 23S rRNA
C5Q97_RS11240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5Q97_RS11245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5Q97_RS11250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5Q97_RS11255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5Q97_RS11260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5Q97_RS11270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5Q97_RS11275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5Q97_RS11280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5Q97_RS11285	COG0255	Belongs to the universal ribosomal protein uL29 family
C5Q97_RS11290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5Q97_RS11300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5Q97_RS11315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5Q97_RS11355	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C5Q97_RS11380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C5Q97_RS11390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5Q97_RS11395	COG0028	Belongs to the TPP enzyme family
C5Q97_RS11400	COG1376	ErfK ybiS ycfS ynhG family protein
C5Q97_RS11405	COG0825	malonyl-CoA metabolic process
C5Q97_RS11430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5Q97_RS11435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5Q97_RS11440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5Q97_RS11450	COG2885	chlorophyll binding
C5Q97_RS11460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5Q97_RS11465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C5Q97_RS11470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5Q97_RS11475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5Q97_RS11480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5Q97_RS11485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5Q97_RS11490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5Q97_RS11495	COG0072	phenylalanine-tRNA ligase activity
C5Q97_RS11500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5Q97_RS11505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5Q97_RS11510	COG0552	protein localization to endoplasmic reticulum
C5Q97_RS11530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C5Q97_RS11535	COG0728	peptidoglycan biosynthetic process
C5Q97_RS11540	COG1609	Transcriptional regulator
C5Q97_RS11570	COG0642	Histidine kinase
C5Q97_RS11610	COG0793	Belongs to the peptidase S41A family
C5Q97_RS11620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5Q97_RS11640	COG3754	Rhamnan synthesis protein F
C5Q97_RS11655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5Q97_RS11665	COG0280	phosphate acetyltransferase
C5Q97_RS11670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5Q97_RS11675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5Q97_RS11685	COG0563	adenylate kinase activity
C5Q97_RS11690	COG0124	histidyl-tRNA synthetase
C5Q97_RS11700	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C5Q97_RS11705	COG0343	queuine tRNA-ribosyltransferase activity
C5Q97_RS11710	COG0693	protein deglycase activity
C5Q97_RS11715	COG4974	Belongs to the 'phage' integrase family
C5Q97_RS11730	COG2326	polyphosphate kinase activity
C5Q97_RS11735	COG4948	Mandelate Racemase Muconate Lactonizing
C5Q97_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS11780	COG2201	protein-glutamate methylesterase activity
C5Q97_RS11785	COG0484	heat shock protein binding
C5Q97_RS11790	COG0037	tRNA processing
C5Q97_RS11795	COG1785	Belongs to the alkaline phosphatase family
C5Q97_RS11815	COG2264	protein methyltransferase activity
C5Q97_RS11820	COG0126	phosphoglycerate kinase activity
C5Q97_RS11850	COG0515	serine threonine protein kinase
C5Q97_RS11855	COG4806	L-rhamnose isomerase
C5Q97_RS11865	COG1609	Transcriptional regulator
C5Q97_RS11890	COG0424	maF-like protein
C5Q97_RS11905	COG0439	Biotin carboxylase
C5Q97_RS11910	COG0511	ligase activity, forming carbon-carbon bonds
C5Q97_RS11915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5Q97_RS11935	COG0753	catalase activity
C5Q97_RS11940	COG1570	exodeoxyribonuclease VII activity
C5Q97_RS11945	COG1994	Peptidase M50
C5Q97_RS11950	COG3323	Protein of unknown function (DUF1653)
C5Q97_RS11950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5Q97_RS11995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5Q97_RS12000	COG0556	nucleotide-excision repair
C5Q97_RS12010	COG0668	transmembrane transport
C5Q97_RS12025	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C5Q97_RS12055	COG0515	serine threonine protein kinase
C5Q97_RS12055	COG2815	serine threonine protein kinase
C5Q97_RS12065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C5Q97_RS12070	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C5Q97_RS12085	COG0436	Aminotransferase
C5Q97_RS12090	COG1522	sequence-specific DNA binding
C5Q97_RS12095	COG4589	Belongs to the CDS family
C5Q97_RS12105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C5Q97_RS12110	COG0592	DNA-directed DNA polymerase activity
C5Q97_RS12115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5Q97_RS12120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5Q97_RS12120	COG0731	radical SAM domain protein
C5Q97_RS12135	COG1609	Transcriptional regulator
C5Q97_RS12140	COG0105	UTP biosynthetic process
C5Q97_RS12145	COG2169	Transcriptional regulator
C5Q97_RS12160	COG0196	riboflavin kinase activity
C5Q97_RS12165	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5Q97_RS12195	COG0811	peptide transport
C5Q97_RS12220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5Q97_RS12235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5Q97_RS12240	COG2207	Transcriptional regulator
C5Q97_RS12240	COG0662	Cupin 2, conserved barrel domain protein
C5Q97_RS12255	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5Q97_RS12265	COG2059	Chromate
C5Q97_RS12300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5Q97_RS12300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5Q97_RS12310	COG0516	GMP reductase activity
C5Q97_RS12310	COG0517	IMP dehydrogenase activity
C5Q97_RS12320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5Q97_RS12330	COG0535	radical SAM domain protein
C5Q97_RS12350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5Q97_RS12370	COG0149	triose-phosphate isomerase activity
C5Q97_RS12405	COG4796	Type ii and iii secretion system protein
C5Q97_RS12410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5Q97_RS12415	COG0322	excinuclease ABC activity
C5Q97_RS12430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5Q97_RS12440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C5Q97_RS12450	COG0795	lipopolysaccharide-transporting ATPase activity
C5Q97_RS12465	COG0515	serine threonine protein kinase
C5Q97_RS12465	COG0457	Tetratricopeptide repeat
C5Q97_RS12470	COG0488	(ABC) transporter
C5Q97_RS12475	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C5Q97_RS12490	COG2022	thiamine diphosphate biosynthetic process
C5Q97_RS12495	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5Q97_RS12500	COG2204	response regulator
C5Q97_RS12505	COG1530	ribonuclease E activity
C5Q97_RS12510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5Q97_RS12515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5Q97_RS12535	COG0194	GDP metabolic process
C5Q97_RS12545	COG5297	Belongs to the glycosyl hydrolase family 6
C5Q97_RS12545	COG4733	cellulase activity
C5Q97_RS12550	COG0714	Associated with various cellular activities
C5Q97_RS12570	COG2382	esterase
C5Q97_RS12595	COG1131	(ABC) transporter
C5Q97_RS12610	COG1253	flavin adenine dinucleotide binding
C5Q97_RS12620	COG1187	pseudouridine synthase activity
C5Q97_RS12625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5Q97_RS12630	COG1473	amidohydrolase
C5Q97_RS12635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5Q97_RS12640	COG0540	Belongs to the ATCase OTCase family
C5Q97_RS12645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5Q97_RS12655	COG2188	Transcriptional regulator
C5Q97_RS12660	COG0488	(ABC) transporter
C5Q97_RS12665	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS12670	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS12680	COG1609	Transcriptional regulator
C5Q97_RS12710	COG0704	Plays a role in the regulation of phosphate uptake
C5Q97_RS12720	COG0581	inorganic phosphate transmembrane transporter activity
C5Q97_RS12725	COG0573	inorganic phosphate transmembrane transporter activity
C5Q97_RS12750	COG0670	Belongs to the BI1 family
C5Q97_RS12755	COG1609	Transcriptional regulator
C5Q97_RS12790	COG1609	Transcriptional regulator
C5Q97_RS12815	COG0693	protein deglycase activity
C5Q97_RS12820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5Q97_RS12830	COG2818	Glycosylase
C5Q97_RS12840	COG0166	Belongs to the GPI family
C5Q97_RS12855	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5Q97_RS12865	COG1459	type II secretion system
C5Q97_RS12870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5Q97_RS12875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5Q97_RS12880	COG0301	tRNA thio-modification
C5Q97_RS12885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5Q97_RS12895	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C5Q97_RS12900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5Q97_RS12905	COG0622	Phosphoesterase
C5Q97_RS12910	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C5Q97_RS12915	COG4660	Part of a membrane complex involved in electron transport
C5Q97_RS12920	COG4659	FMN binding
C5Q97_RS12930	COG4656	Part of a membrane complex involved in electron transport
C5Q97_RS12935	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5Q97_RS12935	COG2878	Part of a membrane complex involved in electron transport
C5Q97_RS12940	COG4657	Part of a membrane complex involved in electron transport
C5Q97_RS12960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5Q97_RS12975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5Q97_RS12980	COG0653	protein targeting
C5Q97_RS12985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5Q97_RS12990	COG0335	large ribosomal subunit rRNA binding
C5Q97_RS12995	COG0336	Belongs to the RNA methyltransferase TrmD family
C5Q97_RS13000	COG1837	Belongs to the UPF0109 family
C5Q97_RS13005	COG0228	four-way junction DNA binding
C5Q97_RS13015	COG1609	Transcriptional regulator
C5Q97_RS13020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5Q97_RS13050	COG1242	4 iron, 4 sulfur cluster binding
C5Q97_RS13070	COG3754	Rhamnan synthesis protein F
C5Q97_RS13090	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5Q97_RS13105	COG2361	Protein of unknown function DUF86
C5Q97_RS13120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5Q97_RS13130	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS13135	COG0457	Tetratricopeptide repeat
C5Q97_RS13135	COG0515	serine threonine protein kinase
C5Q97_RS13140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5Q97_RS13145	COG0740	serine-type endopeptidase activity
C5Q97_RS13150	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5Q97_RS13160	COG3250	beta-galactosidase activity
C5Q97_RS13165	COG1609	Transcriptional regulator
C5Q97_RS13170	COG1874	Beta-galactosidase
C5Q97_RS13235	COG2731	YhcH YjgK YiaL family protein
C5Q97_RS13240	COG3119	arylsulfatase activity
C5Q97_RS13240	COG3408	Glycogen debranching enzyme
C5Q97_RS13305	COG0582	viral genome integration into host DNA
C5Q97_RS13310	COG0612	Peptidase, M16
C5Q97_RS13315	COG0842	Transport permease protein
C5Q97_RS13320	COG1129	ABC transporter
C5Q97_RS13320	COG0842	Transport permease protein
C5Q97_RS13325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5Q97_RS13345	COG1609	Transcriptional regulator
C5Q97_RS13380	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C5Q97_RS13390	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C5Q97_RS13395	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C5Q97_RS13405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5Q97_RS13410	COG1070	Carbohydrate kinase
C5Q97_RS13445	COG0517	IMP dehydrogenase activity
C5Q97_RS13475	COG1904	glucuronate isomerase
C5Q97_RS13480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5Q97_RS13505	COG2165	general secretion pathway protein
C5Q97_RS13520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5Q97_RS13525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5Q97_RS13545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5Q97_RS13565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5Q97_RS13570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5Q97_RS13590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5Q97_RS13595	COG0081	regulation of translation
C5Q97_RS13600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5Q97_RS13605	COG0222	ribosome binding
C5Q97_RS13610	COG0085	RNA polymerase activity
C5Q97_RS13615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5Q97_RS13620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5Q97_RS13625	COG0049	tRNA binding
C5Q97_RS13630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5Q97_RS13635	COG0051	transcription antitermination factor activity, RNA binding
C5Q97_RS13640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5Q97_RS13645	COG0088	Forms part of the polypeptide exit tunnel
C5Q97_RS13650	COG0089	rRNA binding
C5Q97_RS13655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5Q97_RS13660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5Q97_RS13670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5Q97_RS13675	COG0792	nuclease activity
C5Q97_RS13680	COG1040	competence protein
C5Q97_RS13700	COG1882	Formate acetyltransferase
C5Q97_RS13705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5Q97_RS13710	COG0515	serine threonine protein kinase
C5Q97_RS13720	COG3458	cephalosporin-C deacetylase activity
C5Q97_RS13735	COG3250	beta-galactosidase activity
C5Q97_RS13745	COG3534	alpha-L-arabinofuranosidase
C5Q97_RS13765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C5Q97_RS13770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5Q97_RS13775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5Q97_RS13790	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C5Q97_RS13790	COG0778	Nitroreductase
C5Q97_RS13800	COG5492	domain, Protein
C5Q97_RS13860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5Q97_RS13870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5Q97_RS13875	COG3008	intermembrane lipid transfer
C5Q97_RS13885	COG4977	sequence-specific DNA binding
C5Q97_RS13890	COG0546	phosphoglycolate phosphatase activity
C5Q97_RS13900	COG0539	negative regulation of cytoplasmic translation
C5Q97_RS13900	COG2183	response to ionizing radiation
C5Q97_RS13925	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C5Q97_RS13935	COG3458	cephalosporin-C deacetylase activity
C5Q97_RS13990	COG0328	RNA-DNA hybrid ribonuclease activity
C5Q97_RS14010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5Q97_RS14015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5Q97_RS14030	COG0613	PHP domain protein
C5Q97_RS14035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C5Q97_RS14040	COG1164	Oligoendopeptidase f
C5Q97_RS14045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5Q97_RS14050	COG0584	glycerophosphoryl diester phosphodiesterase
C5Q97_RS14055	COG1686	Belongs to the peptidase S11 family
C5Q97_RS14060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5Q97_RS14065	COG1691	(AIR) carboxylase
C5Q97_RS14070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5Q97_RS14120	COG2814	Major facilitator Superfamily
C5Q97_RS14130	COG1621	beta-fructofuranosidase activity
C5Q97_RS14135	COG2207	Transcriptional regulator
C5Q97_RS14140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5Q97_RS14165	COG0538	isocitrate dehydrogenase activity
C5Q97_RS14190	COG1757	Na H antiporter
C5Q97_RS14215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5Q97_RS14220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5Q97_RS14230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5Q97_RS14235	COG0543	2 iron, 2 sulfur cluster binding
C5Q97_RS14290	COG3250	beta-galactosidase activity
C5Q97_RS14300	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C5Q97_RS14305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5Q97_RS14310	COG2095	MarC family integral membrane protein
C5Q97_RS14320	COG1609	Transcriptional regulator
C5Q97_RS14335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5Q97_RS14340	COG0416	fatty acid biosynthetic process
C5Q97_RS14345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5Q97_RS14355	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C5Q97_RS14360	COG1609	Transcriptional regulator
C5Q97_RS14375	COG4989	oxidoreductase activity
C5Q97_RS14390	COG2188	Transcriptional regulator
C5Q97_RS14395	COG1609	Transcriptional regulator
C5Q97_RS14415	COG0584	glycerophosphoryl diester phosphodiesterase
C5Q97_RS14420	COG2207	Transcriptional regulator
C5Q97_RS14420	COG1917	Cupin 2, conserved barrel domain protein
C5Q97_RS14435	COG1840	ABC-type Fe3 transport system, periplasmic component
C5Q97_RS14440	COG3842	ATPase activity
C5Q97_RS14445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C5Q97_RS14500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C5Q97_RS14505	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C5Q97_RS14515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5Q97_RS14520	COG0772	Belongs to the SEDS family
C5Q97_RS14525	COG4284	Utp--glucose-1-phosphate uridylyltransferase
C5Q97_RS14535	COG2165	general secretion pathway protein
C5Q97_RS14540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5Q97_RS14550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5Q97_RS14555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5Q97_RS14565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5Q97_RS14585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5Q97_RS14590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5Q97_RS14595	COG1120	ATPase activity
C5Q97_RS14625	COG2082	Precorrin-8x methylmutase
C5Q97_RS14630	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C5Q97_RS14650	COG1797	cobyrinic acid a,c-diamide synthase activity
C5Q97_RS14655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C5Q97_RS14670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C5Q97_RS14690	COG1609	Transcriptional regulator
C5Q97_RS14715	COG0330	HflC and HflK could
C5Q97_RS14855	COG2217	Heavy metal translocating P-type atpase
C5Q97_RS14860	COG0640	Transcriptional regulator
C5Q97_RS14890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5Q97_RS14895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5Q97_RS14930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5Q97_RS14930	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5Q97_RS14935	COG2207	Transcriptional regulator
C5Q97_RS14935	COG1609	Transcriptional regulator
C5Q97_RS14970	COG0285	dihydrofolate synthase activity
C5Q97_RS14975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5Q97_RS14990	COG1663	tetraacyldisaccharide 4'-kinase activity
C5Q97_RS14995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5Q97_RS15005	COG0180	Tryptophanyl-tRNA synthetase
C5Q97_RS15015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5Q97_RS15035	COG1609	Transcriptional regulator
C5Q97_RS15045	COG3250	beta-galactosidase activity
C5Q97_RS15055	COG1785	Belongs to the alkaline phosphatase family
C5Q97_RS15065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5Q97_RS15070	COG0662	Cupin 2, conserved barrel domain protein
C5Q97_RS15070	COG2207	Transcriptional regulator
C5Q97_RS15080	COG5012	cobalamin binding
C5Q97_RS15105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5Q97_RS15115	COG0688	phosphatidylethanolamine metabolic process
C5Q97_RS15120	COG1183	phosphatidylcholine synthase activity
C5Q97_RS15145	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5Q97_RS15150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C5Q97_RS15165	COG3250	beta-galactosidase activity
C5Q97_RS15215	COG1609	Transcriptional regulator
C5Q97_RS15220	COG4537	Required for transformation and DNA binding
C5Q97_RS15240	COG1363	Peptidase, m42
C5Q97_RS15250	COG2188	Transcriptional regulator
C5Q97_RS15260	COG2165	general secretion pathway protein
C5Q97_RS15290	COG1874	Beta-galactosidase
C5Q97_RS15300	COG1609	Transcriptional regulator
C5Q97_RS15310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5Q97_RS15320	COG1609	Transcriptional regulator
C5Q97_RS15340	COG2207	Transcriptional regulator
C5Q97_RS15360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5Q97_RS15365	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS15370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5Q97_RS15375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5Q97_RS15380	COG1652	LysM domain
C5Q97_RS15385	COG1702	phosphate starvation-inducible protein PhoH
C5Q97_RS15390	COG1480	7TM receptor with intracellular HD hydrolase
C5Q97_RS15395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5Q97_RS15415	COG2365	Tyrosine phosphatase family
C5Q97_RS15430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5Q97_RS15455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5Q97_RS15475	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS15485	COG0438	transferase activity, transferring glycosyl groups
C5Q97_RS15525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5Q97_RS15530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5Q97_RS15535	COG0583	DNA-binding transcription factor activity
C5Q97_RS15540	COG2855	membrane
C5Q97_RS15545	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS15555	COG2056	Na+-H+ antiporter family
C5Q97_RS15560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5Q97_RS15560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5Q97_RS15565	COG1609	Transcriptional regulator
C5Q97_RS15595	COG4977	sequence-specific DNA binding
C5Q97_RS15600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5Q97_RS15605	COG4464	protein tyrosine phosphatase activity
C5Q97_RS15680	COG4964	Belongs to the GSP D family
C5Q97_RS15685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5Q97_RS15695	COG2165	general secretion pathway protein
C5Q97_RS15725	COG1725	Transcriptional regulator
C5Q97_RS15750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5Q97_RS15755	COG0156	8-amino-7-oxononanoate synthase activity
C5Q97_RS15770	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C5Q97_RS15775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5Q97_RS15775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5Q97_RS15780	COG0655	NAD(P)H dehydrogenase (quinone) activity
C5Q97_RS15785	COG2003	Belongs to the UPF0758 family
C5Q97_RS15790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5Q97_RS15800	COG1132	(ABC) transporter
C5Q97_RS15845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5Q97_RS15850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C5Q97_RS15855	COG1802	Transcriptional regulator
C5Q97_RS15900	COG1088	dTDP-glucose 4,6-dehydratase activity
C5Q97_RS15905	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5Q97_RS15940	COG0203	ribosomal protein L17
C5Q97_RS15945	COG0202	RNA polymerase activity
C5Q97_RS15950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5Q97_RS15955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5Q97_RS15960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5Q97_RS15970	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C5Q97_RS15990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C5Q97_RS15995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5Q97_RS15995	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C5Q97_RS16060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C5Q97_RS16110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5Q97_RS16115	COG1609	Transcriptional regulator
C5Q97_RS16135	COG1609	Transcriptional regulator
C5Q97_RS16140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5Q97_RS16175	COG0631	protein serine/threonine phosphatase activity
C5Q97_RS16180	COG4608	Belongs to the ABC transporter superfamily
C5Q97_RS16190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5Q97_RS16195	COG1872	DUF167
C5Q97_RS16200	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
C5Q97_RS16210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C5Q97_RS16215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5Q97_RS16215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5Q97_RS16230	COG0038	chloride channel
C5Q97_RS16280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5Q97_RS16285	COG1418	mRNA catabolic process
C5Q97_RS16290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5Q97_RS16295	COG1012	belongs to the aldehyde dehydrogenase family
C5Q97_RS16300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5Q97_RS16310	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C5Q97_RS16315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5Q97_RS16320	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5Q97_RS16325	COG0022	dehydrogenase e1 component
C5Q97_RS16330	COG1349	DNA-binding transcription factor activity
C5Q97_RS16340	COG1609	Transcriptional regulator
C5Q97_RS16395	COG1609	Transcriptional regulator
C5Q97_RS16400	COG3250	beta-galactosidase activity
C5Q97_RS16425	COG1082	Xylose isomerase domain protein TIM barrel
C5Q97_RS16455	COG1609	Transcriptional regulator
C5Q97_RS16460	COG2890	protein-(glutamine-N5) methyltransferase activity
C5Q97_RS16480	COG1609	Transcriptional regulator
C5Q97_RS16500	COG0772	Belongs to the SEDS family
C5Q97_RS16505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5Q97_RS16510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5Q97_RS16515	COG1269	ATP hydrolysis coupled proton transport
C5Q97_RS16535	COG0450	alkyl hydroperoxide reductase
C5Q97_RS16570	COG1882	Formate acetyltransferase
C5Q97_RS16590	COG1704	LemA family
C5Q97_RS16595	COG0148	phosphopyruvate hydratase activity
C5Q97_RS16645	COG4974	Belongs to the 'phage' integrase family
C5Q97_RS16665	COG3034	peptidoglycan biosynthetic process
C5Q97_RS16685	COG0495	leucyl-tRNA aminoacylation
C5Q97_RS16725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5Q97_RS16755	COG1234	tRNA 3'-trailer cleavage
C5Q97_RS16765	COG3250	beta-galactosidase activity
C5Q97_RS16800	COG0668	transmembrane transport
C5Q97_RS16865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5Q97_RS16905	COG2217	Heavy metal translocating P-type atpase
C5Q97_RS16920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5Q97_RS16935	COG0138	bifunctional purine biosynthesis protein purh
C5Q97_RS16940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5Q97_RS16945	COG0470	DNA polymerase III
C5Q97_RS16950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5Q97_RS16955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5Q97_RS16955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5Q97_RS16960	COG0726	polysaccharide deacetylase
C5Q97_RS16980	COG2226	methyltransferase
C5Q97_RS16985	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C5Q97_RS17005	COG2814	Major facilitator Superfamily
C5Q97_RS17020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C5Q97_RS17035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5Q97_RS17045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5Q97_RS17050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5Q97_RS17080	COG1073	alpha beta
C5Q97_RS17090	COG2207	Transcriptional regulator
C5Q97_RS17090	COG1609	Transcriptional regulator
C5Q97_RS17095	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS17125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5Q97_RS17130	COG1519	Transferase
C5Q97_RS17135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C5Q97_RS17140	COG3254	rhamnose metabolic process
C5Q97_RS17155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5Q97_RS17160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5Q97_RS17165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5Q97_RS17170	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5Q97_RS17180	COG2954	triphosphatase activity
C5Q97_RS17185	COG0363	glucosamine-6-phosphate deaminase activity
C5Q97_RS17195	COG1129	ABC transporter
C5Q97_RS17200	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5Q97_RS17205	COG1879	ABC-type sugar transport system periplasmic component
C5Q97_RS17220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5Q97_RS17235	COG2188	Transcriptional regulator
C5Q97_RS17245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5Q97_RS17250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5Q97_RS17320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5Q97_RS17325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5Q97_RS17330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5Q97_RS17340	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C5Q97_RS17365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5Q97_RS17375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5Q97_RS17380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5Q97_RS17385	COG0195	Participates in both transcription termination and antitermination
C5Q97_RS17405	COG0287	Prephenate dehydrogenase
C5Q97_RS17410	COG1119	ATPase activity
C5Q97_RS17440	COG1917	Cupin 2, conserved barrel domain protein
C5Q97_RS17440	COG2207	Transcriptional regulator
C5Q97_RS17445	COG1486	melibiose metabolic process
C5Q97_RS17455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5Q97_RS17455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5Q97_RS17460	COG1692	metallophosphoesterase
C5Q97_RS17495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5Q97_RS17510	COG0423	glycine-tRNA ligase activity
C5Q97_RS17520	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS17535	COG1902	pentaerythritol trinitrate reductase activity
C5Q97_RS17555	COG3458	cephalosporin-C deacetylase activity
C5Q97_RS17560	COG3458	cephalosporin-C deacetylase activity
C5Q97_RS17570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5Q97_RS17585	COG1722	exodeoxyribonuclease VII activity
C5Q97_RS17590	COG0288	reversible hydration of carbon dioxide
C5Q97_RS17595	COG3458	cephalosporin-C deacetylase activity
C5Q97_RS17605	COG0191	fructose-bisphosphate aldolase activity
C5Q97_RS17610	COG1342	Belongs to the UPF0251 family
C5Q97_RS17620	COG1185	polyribonucleotide nucleotidyltransferase activity
C5Q97_RS17650	COG0297	glycogen (starch) synthase activity
C5Q97_RS17655	COG1881	PFAM PEBP family protein
C5Q97_RS17665	COG1472	Belongs to the glycosyl hydrolase 3 family
C5Q97_RS17670	COG0688	phosphatidylethanolamine metabolic process
C5Q97_RS17685	COG0590	tRNA wobble adenosine to inosine editing
C5Q97_RS17690	COG0004	ammonium transporteR
C5Q97_RS17695	COG0347	Belongs to the P(II) protein family
C5Q97_RS17710	COG2207	Transcriptional regulator
C5Q97_RS17710	COG3708	Transcriptional regulator
C5Q97_RS17745	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5Q97_RS17750	COG0237	dephospho-CoA kinase activity
C5Q97_RS17755	COG0494	nUDIX hydrolase
C5Q97_RS17775	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS17795	COG0432	Pfam Uncharacterised protein family UPF0047
C5Q97_RS17805	COG1882	Formate acetyltransferase
C5Q97_RS17810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5Q97_RS17825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C5Q97_RS17850	COG1609	Transcriptional regulator
C5Q97_RS17865	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS17880	COG0604	alcohol dehydrogenase
C5Q97_RS17880	COG3321	synthase
C5Q97_RS17880	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS17900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5Q97_RS17935	COG1609	Transcriptional regulator
C5Q97_RS17940	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C5Q97_RS17970	COG2255	four-way junction helicase activity
C5Q97_RS17990	COG1199	ATP-dependent helicase activity
C5Q97_RS17990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5Q97_RS18010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5Q97_RS18040	COG2848	UPF0210 protein
C5Q97_RS18045	COG3830	Belongs to the UPF0237 family
C5Q97_RS18065	COG0784	Response regulator, receiver
C5Q97_RS18065	COG2198	Histidine kinase
C5Q97_RS18065	COG5002	protein histidine kinase activity
C5Q97_RS18100	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C5Q97_RS18105	COG0534	Mate efflux family protein
C5Q97_RS18125	COG0357	Ribosomal RNA small subunit methyltransferase G
C5Q97_RS18135	COG2816	NAD+ diphosphatase activity
C5Q97_RS18140	COG0084	hydrolase, TatD family'
C5Q97_RS18155	COG1160	GTP binding
C5Q97_RS18160	COG0284	orotidine-5'-phosphate decarboxylase activity
C5Q97_RS18185	COG0557	exoribonuclease II activity
C5Q97_RS18190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C5Q97_RS18240	COG0564	pseudouridine synthase activity
C5Q97_RS18265	COG0826	peptidase U32
C5Q97_RS18285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C5Q97_RS18295	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5Q97_RS18320	COG1215	transferase activity, transferring glycosyl groups
C5Q97_RS18380	COG1086	Polysaccharide biosynthesis protein
C5Q97_RS18400	COG0438	transferase activity, transferring glycosyl groups
C5Q97_RS18420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5Q97_RS18425	COG1486	melibiose metabolic process
C5Q97_RS18455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C5Q97_RS18465	COG3250	beta-galactosidase activity
C5Q97_RS18485	COG2205	protein histidine kinase activity
C5Q97_RS18490	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C5Q97_RS18500	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5Q97_RS18510	COG5002	protein histidine kinase activity
C5Q97_RS18525	COG4176	ABC-type proline glycine betaine transport system permease component
C5Q97_RS18530	COG4175	Glycine betaine
C5Q97_RS18530	COG0517	IMP dehydrogenase activity
C5Q97_RS18545	COG0686	Belongs to the AlaDH PNT family
C5Q97_RS18560	COG5297	Belongs to the glycosyl hydrolase family 6
C5Q97_RS18560	COG4733	cellulase activity
C5Q97_RS18575	COG2207	Transcriptional regulator
C5Q97_RS18585	COG3250	beta-galactosidase activity
C5Q97_RS18615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5Q97_RS18625	COG1064	alcohol dehydrogenase
C5Q97_RS18635	COG0515	serine threonine protein kinase
C5Q97_RS18650	COG0667	Aldo Keto reductase
C5Q97_RS18660	COG1373	ATPase (AAA superfamily
C5Q97_RS18665	COG1373	ATPase (AAA superfamily
C5Q97_RS18680	COG4104	PAAR repeat-containing protein
C5Q97_RS18680	COG3209	COG3209 Rhs family protein
C5Q97_RS18685	COG2801	Transposase and inactivated derivatives
C5Q97_RS18725	COG2165	general secretion pathway protein
C5Q97_RS18860	COG1525	nuclease
C5Q97_RS18945	COG0037	tRNA processing
C5Q97_RS18965	COG1475	DNA binding
C5Q97_RS19005	COG0629	single-stranded DNA binding
C5Q97_RS19020	COG4712	double-strand break repair protein
C5Q97_RS19055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5Q97_RS19060	COG1690	Belongs to the RtcB family
C5Q97_RS19065	COG0430	RNA-3'-phosphate cyclase activity
C5Q97_RS19070	COG4650	regulator
C5Q97_RS19100	COG1609	Transcriptional regulator
C5Q97_RS19125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5Q97_RS19150	COG4968	Prepilin-type N-terminal cleavage methylation domain
C5Q97_RS19165	COG1609	Transcriptional regulator
C5Q97_RS19170	COG1609	Transcriptional regulator
C5Q97_RS19175	COG2205	protein histidine kinase activity
C5Q97_RS19175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Q97_RS19180	COG2205	protein histidine kinase activity
C5Q97_RS19180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Q97_RS19185	COG2205	protein histidine kinase activity
C5Q97_RS19185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Q97_RS19190	COG0515	serine threonine protein kinase
C5Q97_RS19190	COG0457	Tetratricopeptide repeat
C5Q97_RS19205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5Q97_RS19225	COG1596	polysaccharide export
C5Q97_RS19245	COG1216	Glycosyl transferase, family 2
C5Q97_RS19250	COG1216	Glycosyl transferase, family 2
C5Q97_RS19260	COG3291	Pkd domain containing protein
C5Q97_RS19285	COG0438	transferase activity, transferring glycosyl groups
C5Q97_RS19305	COG1609	Transcriptional regulator
C5Q97_RS19310	COG4968	Prepilin-type N-terminal cleavage methylation domain
C5Q97_RS19355	COG1611	Belongs to the LOG family
C5Q97_RS19370	COG0482	sulfurtransferase activity
C5Q97_RS19375	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C5Q97_RS19405	COG0515	serine threonine protein kinase
C5Q97_RS19405	COG0457	Tetratricopeptide repeat
C5Q97_RS19420	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C5Q97_RS19425	COG3969	phosphoadenosine phosphosulfate
C5Q97_RS19430	COG1475	DNA binding
C5Q97_RS19435	COG1592	Rubrerythrin
C5Q97_RS19460	COG1132	(ABC) transporter
C5Q97_RS19465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C5Q97_RS19495	COG0463	Glycosyl transferase, family 2
C5Q97_RS19500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5Q97_RS19515	COG1136	(ABC) transporter
C5Q97_RS19515	COG0577	efflux transmembrane transporter activity
C5Q97_RS19520	COG1136	(ABC) transporter
C5Q97_RS19520	COG0577	efflux transmembrane transporter activity
C5Q97_RS19530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5Q97_RS19560	COG0534	Mate efflux family protein
C5Q97_RS19565	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5Q97_RS19585	COG0583	DNA-binding transcription factor activity
C5Q97_RS19595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5Q97_RS19615	COG1929	Belongs to the glycerate kinase type-1 family
C5Q97_RS19620	COG1058	Belongs to the CinA family
C5Q97_RS19620	COG1546	Belongs to the CinA family
C5Q97_RS19630	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5Q97_RS19635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5Q97_RS19640	COG4232	protein-disulfide reductase activity
C5Q97_RS19650	COG0076	glutamate decarboxylase activity
C5Q97_RS19665	COG0583	DNA-binding transcription factor activity
C5Q97_RS19685	COG0363	glucosamine-6-phosphate deaminase activity
C5Q97_RS19690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5Q97_RS19705	COG0456	acetyltransferase
C5Q97_RS19725	COG0463	Glycosyl transferase, family 2
C5Q97_RS19725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5Q97_RS19730	COG0438	transferase activity, transferring glycosyl groups
C5Q97_RS19745	COG1129	ABC transporter
C5Q97_RS19750	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5Q97_RS19765	COG1609	Transcriptional regulator
C5Q97_RS19770	COG0393	Putative heavy-metal-binding
C5Q97_RS19775	COG0393	Putative heavy-metal-binding
C5Q97_RS19795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5Q97_RS19810	COG1561	YicC-like family, N-terminal region
C5Q97_RS19815	COG1045	serine acetyltransferase
C5Q97_RS19820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5Q97_RS19825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5Q97_RS19850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5Q97_RS19855	COG0504	CTP synthase activity
C5Q97_RS19860	COG0505	Belongs to the CarA family
C5Q97_RS19865	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C5Q97_RS19875	COG0067	glutamate synthase
C5Q97_RS19875	COG0069	glutamate synthase activity
C5Q97_RS19875	COG0070	glutamate synthase
C5Q97_RS19885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5Q97_RS19890	COG0436	Aminotransferase
C5Q97_RS19900	COG0693	protein deglycase activity
C5Q97_RS19905	COG1592	Rubrerythrin
C5Q97_RS19910	COG0673	inositol 2-dehydrogenase activity
C5Q97_RS19915	COG0768	penicillin binding
C5Q97_RS19940	COG0351	phosphomethylpyrimidine kinase
C5Q97_RS20025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C5Q97_RS20040	COG0534	Mate efflux family protein
C5Q97_RS20045	COG0561	phosphatase activity
C5Q97_RS20055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5Q97_RS20060	COG0513	Belongs to the DEAD box helicase family
C5Q97_RS20065	COG5002	protein histidine kinase activity
C5Q97_RS20095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5Q97_RS20115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5Q97_RS20130	COG1704	LemA family
C5Q97_RS20135	COG0501	Belongs to the peptidase M48B family
C5Q97_RS20145	COG1609	Transcriptional regulator
C5Q97_RS20165	COG1132	(ABC) transporter
C5Q97_RS20200	COG1012	belongs to the aldehyde dehydrogenase family
C5Q97_RS20200	COG1454	alcohol dehydrogenase
C5Q97_RS20260	COG1609	Transcriptional regulator
C5Q97_RS20275	COG2211	Major facilitator Superfamily
C5Q97_RS20290	COG2165	general secretion pathway protein
C5Q97_RS20310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5Q97_RS20325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5Q97_RS20330	COG0667	Aldo Keto reductase
C5Q97_RS20365	COG0583	DNA-binding transcription factor activity
C5Q97_RS20385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5Q97_RS20415	COG3250	beta-galactosidase activity
C5Q97_RS20420	COG1609	Transcriptional regulator
C5Q97_RS20485	COG1959	2 iron, 2 sulfur cluster binding
C5Q97_RS20490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5Q97_RS20500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5Q97_RS20510	COG1450	Type ii and iii secretion system protein
C5Q97_RS20535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5Q97_RS20545	COG3665	Urea carboxylase-associated protein
C5Q97_RS20550	COG3665	Urea carboxylase-associated protein
C5Q97_RS20555	COG3665	Urea carboxylase-associated protein
C5Q97_RS20570	COG0657	acetylesterase activity
C5Q97_RS20620	COG1609	Transcriptional regulator
C5Q97_RS20650	COG1132	(ABC) transporter
C5Q97_RS20655	COG3842	ATPase activity
C5Q97_RS20670	COG0233	cytoplasmic translational termination
C5Q97_RS20690	COG1073	alpha beta
C5Q97_RS20730	COG2086	electron transfer activity
C5Q97_RS20735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5Q97_RS20740	COG1960	acyl-CoA dehydrogenase activity
C5Q97_RS20745	COG1758	RNA polymerase activity
C5Q97_RS20750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C5Q97_RS20755	COG2095	MarC family integral membrane protein
C5Q97_RS20760	COG2362	D-Aminopeptidase
C5Q97_RS20770	COG1366	Belongs to the anti-sigma-factor antagonist family
C5Q97_RS20780	COG2274	protein secretion by the type I secretion system
C5Q97_RS20790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5Q97_RS20800	COG1917	Cupin 2, conserved barrel domain protein
C5Q97_RS20800	COG2207	Transcriptional regulator
C5Q97_RS20820	COG1609	Transcriptional regulator
C5Q97_RS20870	COG4977	sequence-specific DNA binding
C5Q97_RS20890	COG1959	2 iron, 2 sulfur cluster binding
C5Q97_RS20910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5Q97_RS20915	COG3830	Belongs to the UPF0237 family
C5Q97_RS20915	COG0560	Phosphoserine phosphatase
C5Q97_RS20925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5Q97_RS20955	COG0512	Glutamine amidotransferase of anthranilate synthase
C5Q97_RS20960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5Q97_RS20965	COG0134	indole-3-glycerol-phosphate synthase activity
C5Q97_RS20970	COG0135	phosphoribosylanthranilate isomerase activity
C5Q97_RS20980	COG0159	tryptophan synthase activity
C5Q97_RS21000	COG1234	tRNA 3'-trailer cleavage
C5Q97_RS21010	COG4753	response regulator
C5Q97_RS21010	COG2207	Transcriptional regulator
C5Q97_RS21050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5Q97_RS21050	COG0646	methionine synthase
C5Q97_RS21060	COG4948	Mandelate Racemase Muconate Lactonizing
C5Q97_RS21075	COG3693	PFAM glycoside hydrolase, family 10
C5Q97_RS21080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5Q97_RS21080	COG0473	3-isopropylmalate dehydrogenase activity
C5Q97_RS21085	COG1028	Short-chain dehydrogenase reductase Sdr
C5Q97_RS21090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5Q97_RS21105	COG0483	inositol monophosphate 1-phosphatase activity
C5Q97_RS21120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5Q97_RS21165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5Q97_RS21195	COG1643	Atp-dependent helicase
C5Q97_RS21205	COG0131	Imidazoleglycerol-phosphate dehydratase
C5Q97_RS21215	COG2205	protein histidine kinase activity
C5Q97_RS21215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Q97_RS21225	COG1349	DNA-binding transcription factor activity
C5Q97_RS21240	COG3718	enzyme involved in inositol metabolism
C5Q97_RS21245	COG1070	Carbohydrate kinase
C5Q97_RS21250	COG0277	FAD linked oxidase domain protein
C5Q97_RS21270	COG0534	Mate efflux family protein
C5Q97_RS21280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5Q97_RS21315	COG0716	FMN binding
C5Q97_RS21355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5Q97_RS21360	COG0617	tRNA 3'-terminal CCA addition
C5Q97_RS21365	COG1649	PFAM Uncharacterised BCR, COG1649
C5Q97_RS21370	COG0438	transferase activity, transferring glycosyl groups
C5Q97_RS21375	COG1215	transferase activity, transferring glycosyl groups
C5Q97_RS21395	COG0484	heat shock protein binding
C5Q97_RS21400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5Q97_RS21415	COG3250	beta-galactosidase activity
C5Q97_RS21420	COG1609	Transcriptional regulator
C5Q97_RS21435	COG2326	polyphosphate kinase activity
C5Q97_RS21440	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C5Q97_RS21455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5Q97_RS21485	COG1609	Transcriptional regulator