locus-tag	class	description
A21D_RS00120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A21D_RS00120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A21D_RS00215	COG0582	viral genome integration into host DNA
A21D_RS00220	COG0719	Fe-S assembly protein
A21D_RS00225	COG0822	iron-sulfur transferase activity
A21D_RS00230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A21D_RS00235	COG0719	Fe-S assembly protein
A21D_RS00240	COG0396	ATPase activity
A21D_RS00245	COG1464	Belongs to the NlpA lipoprotein family
A21D_RS00250	COG2011	ABC-type metal ion transport system permease component
A21D_RS00255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A21D_RS00260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A21D_RS00270	COG0509	glycine decarboxylation via glycine cleavage system
A21D_RS00275	COG1393	Belongs to the ArsC family
A21D_RS00280	COG1960	acyl-CoA dehydrogenase activity
A21D_RS00285	COG0183	Belongs to the thiolase family
A21D_RS00290	COG1024	Enoyl-CoA hydratase
A21D_RS00290	COG1250	3-hydroxyacyl-CoA dehydrogenase
A21D_RS00300	COG1121	(ABC) transporter
A21D_RS00305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A21D_RS00310	COG0735	belongs to the Fur family
A21D_RS00315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A21D_RS00330	COG2076	Multidrug Resistance protein
A21D_RS00335	COG2076	Multidrug Resistance protein
A21D_RS00340	COG1253	flavin adenine dinucleotide binding
A21D_RS00350	COG3883	PFAM NLP P60 protein
A21D_RS00350	COG0791	NLP P60 protein
A21D_RS00355	COG2224	Isocitrate lyase
A21D_RS00360	COG4129	membrane
A21D_RS00365	COG2197	response regulator
A21D_RS00390	COG0586	Pfam SNARE associated Golgi protein
A21D_RS00395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A21D_RS00410	COG0517	IMP dehydrogenase activity
A21D_RS00425	COG0745	RESPONSE REGULATOR receiver
A21D_RS00430	COG2205	protein histidine kinase activity
A21D_RS00435	COG1136	(ABC) transporter
A21D_RS00440	COG0577	efflux transmembrane transporter activity
A21D_RS00450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A21D_RS00455	COG0557	exoribonuclease II activity
A21D_RS00460	COG1647	Serine aminopeptidase, S33
A21D_RS00465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A21D_RS00480	COG0084	hydrolase, TatD family'
A21D_RS00485	COG1116	anion transmembrane transporter activity
A21D_RS00490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A21D_RS00500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A21D_RS00505	COG0148	phosphopyruvate hydratase activity
A21D_RS00510	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A21D_RS00515	COG0149	triose-phosphate isomerase activity
A21D_RS00520	COG0126	phosphoglycerate kinase activity
A21D_RS00545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A21D_RS00550	COG0328	RNA-DNA hybrid ribonuclease activity
A21D_RS00555	COG0710	3-dehydroquinate dehydratase activity
A21D_RS00560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A21D_RS00580	COG1984	allophanate hydrolase subunit 2
A21D_RS00585	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A21D_RS00590	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A21D_RS00595	COG1914	H( )-stimulated, divalent metal cation uptake system
A21D_RS00640	COG0740	serine-type endopeptidase activity
A21D_RS00645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS00650	COG1481	regulation of sporulation
A21D_RS00655	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A21D_RS00660	COG1660	Displays ATPase and GTPase activities
A21D_RS00665	COG1051	belongs to the nudix hydrolase family
A21D_RS00670	COG0492	ferredoxin-NADP+ reductase activity
A21D_RS00675	COG0457	Tetratricopeptide repeat
A21D_RS00680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A21D_RS00685	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A21D_RS00690	COG0110	maltose O-acetyltransferase activity
A21D_RS00695	COG0546	phosphoglycolate phosphatase activity
A21D_RS00700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A21D_RS00705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A21D_RS00710	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A21D_RS00715	COG1950	PFAM Membrane protein of
A21D_RS00720	COG1983	PspC domain protein
A21D_RS00730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A21D_RS00735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A21D_RS00740	COG0556	nucleotide-excision repair
A21D_RS00745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A21D_RS00750	COG0726	polysaccharide deacetylase
A21D_RS00760	COG0793	Belongs to the peptidase S41A family
A21D_RS00760	COG3409	Peptidoglycan-binding domain 1 protein
A21D_RS00765	COG0739	heme binding
A21D_RS00770	COG2177	Part of the ABC transporter FtsEX involved in
A21D_RS00775	COG2884	Cell division ATP-binding protein ftsE
A21D_RS00790	COG0653	protein targeting
A21D_RS00800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A21D_RS00810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A21D_RS00820	COG1516	flagellar protein fliS
A21D_RS00825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A21D_RS00830	COG1334	flagellar protein FlaG
A21D_RS00835	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A21D_RS00840	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A21D_RS00850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A21D_RS00855	COG4786	Flagellar basal body rod
A21D_RS00855	COG1256	bacterial-type flagellum assembly
A21D_RS00875	COG1040	competence protein
A21D_RS00880	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A21D_RS00895	COG2197	response regulator
A21D_RS00905	COG1511	domain protein
A21D_RS00910	COG1307	EDD domain protein, DegV family
A21D_RS00915	COG2197	response regulator
A21D_RS00925	COG1739	Uncharacterized protein family UPF0029
A21D_RS00930	COG0363	glucosamine-6-phosphate deaminase activity
A21D_RS00935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A21D_RS00945	COG1316	TRANSCRIPTIONal
A21D_RS00950	COG0768	penicillin binding
A21D_RS00960	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS00970	COG0561	phosphatase activity
A21D_RS00975	COG2814	Major facilitator Superfamily
A21D_RS00980	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A21D_RS00985	COG0471	metal ion transport
A21D_RS00990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A21D_RS00995	COG2814	Major facilitator Superfamily
A21D_RS01010	COG1368	sulfuric ester hydrolase activity
A21D_RS01015	COG0840	transmembrane signaling receptor activity
A21D_RS01020	COG0840	transmembrane signaling receptor activity
A21D_RS01025	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS01050	COG2971	BadF BadG BcrA BcrD
A21D_RS01065	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_RS01085	COG1486	melibiose metabolic process
A21D_RS01090	COG1609	Transcriptional regulator
A21D_RS01100	COG3833	ABC-type maltose transport systems, permease component
A21D_RS01105	COG1175	transmembrane transport
A21D_RS01110	COG2182	Extracellular solute-binding protein
A21D_RS01150	COG0788	formyltetrahydrofolate deformylase activity
A21D_RS01155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A21D_RS01160	COG3639	organic phosphonate transmembrane transporter activity
A21D_RS01165	COG3639	organic phosphonate transmembrane transporter activity
A21D_RS01200	COG1473	amidohydrolase
A21D_RS01210	COG1971	Probably functions as a manganese efflux pump
A21D_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_RS01220	COG2996	Protein conserved in bacteria
A21D_RS01230	COG0561	phosphatase activity
A21D_RS01235	COG2059	Chromate
A21D_RS01240	COG2059	Chromate
A21D_RS01250	COG1522	sequence-specific DNA binding
A21D_RS01255	COG3275	phosphorelay sensor kinase activity
A21D_RS01260	COG3279	Response regulator of the LytR AlgR family
A21D_RS01265	COG1966	Carbon starvation protein
A21D_RS01270	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A21D_RS01275	COG1461	Dihydroxyacetone kinase
A21D_RS01280	COG2376	Dihydroxyacetone kinase
A21D_RS01285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A21D_RS01290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A21D_RS01305	COG0367	asparagine synthase
A21D_RS01320	COG0601	transmembrane transport
A21D_RS01325	COG4608	Belongs to the ABC transporter superfamily
A21D_RS01340	COG1476	TRANSCRIPTIONal
A21D_RS01365	COG1940	carbohydrate kinase activity
A21D_RS01370	COG5426	von Willebrand factor, type A
A21D_RS01375	COG0395	ABC-type sugar transport system, permease component
A21D_RS01380	COG1175	transmembrane transport
A21D_RS01395	COG0366	Alpha amylase catalytic
A21D_RS01400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A21D_RS01410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A21D_RS01415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A21D_RS01420	COG0066	3-isopropylmalate dehydratase activity
A21D_RS01425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A21D_RS01430	COG0473	3-isopropylmalate dehydrogenase activity
A21D_RS01435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A21D_RS01440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A21D_RS01445	COG0440	acetolactate synthase activity
A21D_RS01450	COG0028	Belongs to the TPP enzyme family
A21D_RS01455	COG0129	dihydroxy-acid dehydratase activity
A21D_RS01460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A21D_RS01465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A21D_RS01470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A21D_RS01475	COG2814	Major facilitator Superfamily
A21D_RS01495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A21D_RS01515	COG1247	-acetyltransferase
A21D_RS01525	COG0456	acetyltransferase
A21D_RS01545	COG4474	Belongs to the UPF0398 family
A21D_RS01565	COG1970	mechanosensitive ion channel activity
A21D_RS01575	COG1694	Mazg nucleotide pyrophosphohydrolase
A21D_RS01585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_RS01590	COG1227	inorganic diphosphatase activity
A21D_RS01595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A21D_RS01605	COG0659	secondary active sulfate transmembrane transporter activity
A21D_RS01615	COG0456	acetyltransferase
A21D_RS01615	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A21D_RS01620	COG0768	penicillin binding
A21D_RS01625	COG1271	oxidase subunit
A21D_RS01630	COG1294	oxidase, subunit
A21D_RS01635	COG4988	ABC transporter
A21D_RS01640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A21D_RS01645	COG3142	Participates in the control of copper homeostasis
A21D_RS01650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A21D_RS01655	COG1940	carbohydrate kinase activity
A21D_RS01660	COG1621	beta-fructofuranosidase activity
A21D_RS01680	COG1764	response to oxidative stress
A21D_RS01705	COG0083	homoserine kinase activity
A21D_RS01720	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_RS01725	COG4708	membrane
A21D_RS01760	COG4932	domain protein
A21D_RS01760	COG4886	Leucine-rich repeat (LRR) protein
A21D_RS01780	COG3279	Response regulator of the LytR AlgR family
A21D_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS01785	COG1454	alcohol dehydrogenase
A21D_RS01790	COG2207	Transcriptional regulator
A21D_RS01805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A21D_RS01810	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A21D_RS01825	COG3327	negative regulation of DNA-templated transcription, initiation
A21D_RS01830	COG1024	Enoyl-CoA hydratase
A21D_RS01835	COG0183	Belongs to the thiolase family
A21D_RS01840	COG1250	3-hydroxyacyl-CoA dehydrogenase
A21D_RS01845	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS01850	COG1024	Enoyl-CoA hydratase
A21D_RS01865	COG2151	metal-sulfur cluster biosynthetic enzyme
A21D_RS01880	COG3396	Phenylacetate-CoA oxygenase
A21D_RS01885	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A21D_RS01910	COG3775	system Galactitol-specific IIC component
A21D_RS01915	COG3414	Phosphotransferase system galactitol-specific IIB component
A21D_RS01920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS01945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A21D_RS01950	COG1335	isochorismatase
A21D_RS01960	COG0191	fructose-bisphosphate aldolase activity
A21D_RS01965	COG3962	Belongs to the TPP enzyme family
A21D_RS01970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A21D_RS01980	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS01985	COG1349	DNA-binding transcription factor activity
A21D_RS01990	COG1942	4-Oxalocrotonate Tautomerase
A21D_RS01995	COG0673	inositol 2-dehydrogenase activity
A21D_RS02000	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A21D_RS02005	COG0673	inositol 2-dehydrogenase activity
A21D_RS02010	COG1082	Xylose isomerase domain protein TIM barrel
A21D_RS02015	COG2814	Major facilitator Superfamily
A21D_RS02025	COG3876	Protein conserved in bacteria
A21D_RS02030	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_RS02040	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_RS02050	COG1486	melibiose metabolic process
A21D_RS02055	COG3711	transcriptional antiterminator
A21D_RS02055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS02060	COG1438	arginine binding
A21D_RS02065	COG0549	Belongs to the carbamate kinase family
A21D_RS02075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A21D_RS02085	COG0018	arginyl-trna synthetase
A21D_RS02095	COG3835	regulator
A21D_RS02100	COG2610	gluconate transmembrane transporter activity
A21D_RS02105	COG1929	Belongs to the glycerate kinase type-1 family
A21D_RS02110	COG3527	Alpha-acetolactate decarboxylase
A21D_RS02120	COG0681	Belongs to the peptidase S26 family
A21D_RS02130	COG1785	Belongs to the alkaline phosphatase family
A21D_RS02135	COG0584	glycerophosphoryl diester phosphodiesterase
A21D_RS02175	COG1396	sequence-specific DNA binding
A21D_RS02185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A21D_RS02200	COG0506	proline dehydrogenase activity
A21D_RS02215	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A21D_RS02255	COG0456	acetyltransferase
A21D_RS02260	COG1737	Transcriptional regulator
A21D_RS02265	COG3876	Protein conserved in bacteria
A21D_RS02270	COG1472	Belongs to the glycosyl hydrolase 3 family
A21D_RS02280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A21D_RS02285	COG1122	ATPase activity
A21D_RS02305	COG0183	Belongs to the thiolase family
A21D_RS02310	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_RS02315	COG1268	BioY protein
A21D_RS02320	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A21D_RS02325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS02335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS02335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS02335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS02340	COG3711	transcriptional antiterminator
A21D_RS02340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS02355	COG3732	PTS system glucitol sorbitol-specific
A21D_RS02380	COG0840	transmembrane signaling receptor activity
A21D_RS02385	COG0277	FAD linked oxidase domain protein
A21D_RS02400	COG0531	amino acid
A21D_RS02405	COG0527	aspartate kinase activity
A21D_RS02410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A21D_RS02410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A21D_RS02425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A21D_RS02430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A21D_RS02435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A21D_RS02440	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A21D_RS02445	COG4977	sequence-specific DNA binding
A21D_RS02480	COG1396	sequence-specific DNA binding
A21D_RS02490	COG2851	Citrate transporter
A21D_RS02495	COG4565	transcriptional regulatory protein
A21D_RS02500	COG3290	protein histidine kinase activity
A21D_RS02550	COG3279	Response regulator of the LytR AlgR family
A21D_RS02570	COG2378	regulation of single-species biofilm formation
A21D_RS02575	COG0693	protein deglycase activity
A21D_RS02595	COG1316	TRANSCRIPTIONal
A21D_RS02625	COG0438	transferase activity, transferring glycosyl groups
A21D_RS02630	COG0438	transferase activity, transferring glycosyl groups
A21D_RS02650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A21D_RS02655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A21D_RS02670	COG4464	protein tyrosine phosphatase activity
A21D_RS02675	COG0489	protein tyrosine kinase activity
A21D_RS02680	COG3944	biosynthesis protein
A21D_RS02685	COG0791	NLP P60 protein
A21D_RS02685	COG1388	LysM domain
A21D_RS02700	COG2706	6-phosphogluconolactonase activity
A21D_RS02710	COG3397	chitin binding
A21D_RS02715	COG2188	Transcriptional regulator
A21D_RS02720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A21D_RS02730	COG3964	amidohydrolase
A21D_RS02735	COG5578	integral membrane protein
A21D_RS02740	COG0395	ABC-type sugar transport system, permease component
A21D_RS02760	COG0432	Pfam Uncharacterised protein family UPF0047
A21D_RS02775	COG2814	Major facilitator Superfamily
A21D_RS02800	COG2217	Heavy metal translocating P-type atpase
A21D_RS02805	COG1937	Protein conserved in bacteria
A21D_RS02815	COG1268	BioY protein
A21D_RS02820	COG0300	oxidoreductase activity
A21D_RS02835	COG2856	Zn peptidase
A21D_RS02865	COG2197	response regulator
A21D_RS02890	COG1054	Belongs to the UPF0176 family
A21D_RS02895	COG0840	transmembrane signaling receptor activity
A21D_RS02900	COG0386	Belongs to the glutathione peroxidase family
A21D_RS02910	COG1126	abc transporter atp-binding protein
A21D_RS02915	COG0765	amino acid transport
A21D_RS02920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A21D_RS02930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A21D_RS02935	COG1335	isochorismatase
A21D_RS02940	COG2839	Protein conserved in bacteria
A21D_RS02945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A21D_RS02950	COG1876	peptidase activity
A21D_RS02960	COG0673	inositol 2-dehydrogenase activity
A21D_RS02970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A21D_RS02980	COG0765	amino acid transport
A21D_RS02985	COG0765	amino acid transport
A21D_RS02990	COG1126	abc transporter atp-binding protein
A21D_RS03000	COG3344	reverse transcriptase
A21D_RS03005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A21D_RS03015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A21D_RS03020	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A21D_RS03025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A21D_RS03030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A21D_RS03035	COG0131	Imidazoleglycerol-phosphate dehydratase
A21D_RS03040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A21D_RS03045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A21D_RS03050	COG0107	imidazoleglycerol-phosphate synthase activity
A21D_RS03055	COG0140	phosphoribosyl-ATP diphosphatase activity
A21D_RS03055	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A21D_RS03060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A21D_RS03070	COG4607	ABC-type enterochelin transport system periplasmic component
A21D_RS03075	COG4604	ABC transporter, ATP-binding protein
A21D_RS03080	COG4605	iron ion homeostasis
A21D_RS03085	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A21D_RS03090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A21D_RS03095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_RS03100	COG1304	FMN binding
A21D_RS03105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A21D_RS03115	COG0656	L-ascorbic acid biosynthetic process
A21D_RS03120	COG0488	(ABC) transporter
A21D_RS03125	COG1388	LysM domain
A21D_RS03125	COG3858	chitin binding
A21D_RS03135	COG0840	transmembrane signaling receptor activity
A21D_RS03145	COG0577	efflux transmembrane transporter activity
A21D_RS03145	COG1136	(ABC) transporter
A21D_RS03155	COG2818	Glycosylase
A21D_RS03190	COG1181	Belongs to the D-alanine--D-alanine ligase family
A21D_RS03220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A21D_RS03225	COG0512	Glutamine amidotransferase of anthranilate synthase
A21D_RS03230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A21D_RS03235	COG0134	indole-3-glycerol-phosphate synthase activity
A21D_RS03240	COG0135	phosphoribosylanthranilate isomerase activity
A21D_RS03245	COG0133	tryptophan synthase activity
A21D_RS03250	COG0159	tryptophan synthase activity
A21D_RS03265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_RS03280	COG1131	(ABC) transporter
A21D_RS03285	COG1725	Transcriptional regulator
A21D_RS03290	COG0708	Exodeoxyribonuclease III
A21D_RS03300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_RS03335	COG5506	Protein of unknown function (DUF1694)
A21D_RS03340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_RS03355	COG0693	protein deglycase activity
A21D_RS03360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A21D_RS03365	COG4145	pantothenate transmembrane transporter activity
A21D_RS03415	COG3104	oligopeptide transport
A21D_RS03430	COG0346	lactoylglutathione lyase activity
A21D_RS03435	COG2323	membrane
A21D_RS03440	COG1827	regulation of RNA biosynthetic process
A21D_RS03445	COG1104	cysteine desulfurase activity
A21D_RS03450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A21D_RS03455	COG0157	Belongs to the NadC ModD family
A21D_RS03475	COG3654	unkown
A21D_RS03480	COG4085	toxin activity
A21D_RS03480	COG0737	Belongs to the 5'-nucleotidase family
A21D_RS03480	COG1525	nuclease
A21D_RS03525	COG1131	(ABC) transporter
A21D_RS03530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A21D_RS03540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A21D_RS03545	COG0601	transmembrane transport
A21D_RS03550	COG0747	negative chemotaxis
A21D_RS03555	COG4608	Belongs to the ABC transporter superfamily
A21D_RS03560	COG0444	Belongs to the ABC transporter superfamily
A21D_RS03575	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A21D_RS03580	COG0352	thiamine-phosphate diphosphorylase activity
A21D_RS03590	COG0789	Transcriptional regulator
A21D_RS03595	COG0477	Major facilitator Superfamily
A21D_RS03610	COG1556	Lactate utilization protein
A21D_RS03615	COG1139	Iron-sulfur cluster binding protein
A21D_RS03620	COG0247	lactate metabolic process
A21D_RS03625	COG2186	Transcriptional regulator
A21D_RS03630	COG1620	l-lactate permease
A21D_RS03635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_RS03645	COG2132	Multicopper oxidase
A21D_RS03650	COG0460	homoserine dehydrogenase
A21D_RS03655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A21D_RS03665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A21D_RS03670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A21D_RS03695	COG1131	(ABC) transporter
A21D_RS03715	COG0531	amino acid
A21D_RS03720	COG3250	beta-galactosidase activity
A21D_RS03735	COG1607	acyl-coa hydrolase
A21D_RS03740	COG1413	lyase activity
A21D_RS03750	COG1105	Belongs to the carbohydrate kinase PfkB family
A21D_RS03755	COG1349	DNA-binding transcription factor activity
A21D_RS03765	COG0488	(ABC) transporter
A21D_RS03770	COG1846	Transcriptional regulator
A21D_RS03775	COG0400	carboxylic ester hydrolase activity
A21D_RS03785	COG2514	catechol 2,3-dioxygenase activity
A21D_RS03795	COG0668	transmembrane transport
A21D_RS03800	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A21D_RS03805	COG0535	radical SAM domain protein
A21D_RS03815	COG1802	Transcriptional regulator
A21D_RS03820	COG1114	Component of the transport system for branched-chain amino acids
A21D_RS03825	COG1132	(ABC) transporter
A21D_RS03830	COG3559	Exporter of polyketide antibiotics
A21D_RS03835	COG1131	(ABC) transporter
A21D_RS03850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A21D_RS03850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A21D_RS03855	COG0745	RESPONSE REGULATOR receiver
A21D_RS03855	COG2972	Histidine kinase
A21D_RS03865	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A21D_RS03870	COG4988	ABC transporter
A21D_RS03875	COG1294	oxidase, subunit
A21D_RS03880	COG1271	oxidase subunit
A21D_RS03885	COG1714	RDD family
A21D_RS03890	COG0616	signal peptide processing
A21D_RS03895	COG0351	phosphomethylpyrimidine kinase
A21D_RS03910	COG3973	AAA domain
A21D_RS03925	COG1388	LysM domain
A21D_RS03940	COG1695	Transcriptional regulator
A21D_RS03965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A21D_RS03995	COG5002	protein histidine kinase activity
A21D_RS03995	COG3850	Histidine kinase
A21D_RS04000	COG0745	RESPONSE REGULATOR receiver
A21D_RS04015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A21D_RS04020	COG3064	Membrane
A21D_RS04025	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
A21D_RS04030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A21D_RS04035	COG2153	protein acetylation
A21D_RS04040	COG2084	Dehydrogenase
A21D_RS04055	COG2226	methyltransferase
A21D_RS04070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_RS04075	COG1105	Belongs to the carbohydrate kinase PfkB family
A21D_RS04095	COG3716	PTS system mannose fructose sorbose family IID component
A21D_RS04100	COG3715	PTS system
A21D_RS04105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_RS04110	COG2222	sugar isomerase
A21D_RS04115	COG2188	Transcriptional regulator
A21D_RS04140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A21D_RS04160	COG0494	nUDIX hydrolase
A21D_RS04180	COG1316	TRANSCRIPTIONal
A21D_RS04190	COG1134	teichoic acid transport
A21D_RS04195	COG1682	transport, permease protein
A21D_RS04200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A21D_RS04205	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A21D_RS04215	COG1316	TRANSCRIPTIONal
A21D_RS04225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A21D_RS04250	COG4193	domain, Protein
A21D_RS04255	COG1215	transferase activity, transferring glycosyl groups
A21D_RS04265	COG1134	teichoic acid transport
A21D_RS04270	COG1682	transport, permease protein
A21D_RS04275	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A21D_RS04280	COG0438	transferase activity, transferring glycosyl groups
A21D_RS04310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A21D_RS04315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A21D_RS04325	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A21D_RS04335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A21D_RS04340	COG0095	Lipoate-protein ligase
A21D_RS04345	COG1737	Transcriptional regulator
A21D_RS04350	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A21D_RS04355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_RS04355	COG1263	PTS System
A21D_RS04355	COG2190	(PTS) system
A21D_RS04375	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_RS04380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_RS04385	COG1486	melibiose metabolic process
A21D_RS04390	COG2188	Transcriptional regulator
A21D_RS04395	COG3394	polysaccharide catabolic process
A21D_RS04410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A21D_RS04415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A21D_RS04440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A21D_RS04450	COG4786	Flagellar basal body rod
A21D_RS04455	COG4786	Flagellar basal body rod
A21D_RS04460	COG1077	Cell shape determining protein MreB Mrl
A21D_RS04465	COG1609	Transcriptional regulator
A21D_RS04475	COG2385	sporulation resulting in formation of a cellular spore
A21D_RS04480	COG4608	Belongs to the ABC transporter superfamily
A21D_RS04485	COG0791	NLP P60 protein
A21D_RS04490	COG4166	transmembrane transport
A21D_RS04495	COG0444	Belongs to the ABC transporter superfamily
A21D_RS04500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A21D_RS04505	COG0601	transmembrane transport
A21D_RS04510	COG2362	D-Aminopeptidase
A21D_RS04515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A21D_RS04525	COG4836	Membrane
A21D_RS04530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A21D_RS04535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A21D_RS04540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A21D_RS04545	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A21D_RS04550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A21D_RS04555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A21D_RS04560	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A21D_RS04565	COG0356	it plays a direct role in the translocation of protons across the membrane
A21D_RS04575	COG1404	Belongs to the peptidase S8 family
A21D_RS04580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A21D_RS04585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A21D_RS04595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A21D_RS04600	COG4475	Protein of unknown function (DUF436)
A21D_RS04605	COG0698	ribose 5-phosphate isomerase
A21D_RS04610	COG0840	transmembrane signaling receptor activity
A21D_RS04615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A21D_RS04620	COG1971	Probably functions as a manganese efflux pump
A21D_RS04635	COG0009	L-threonylcarbamoyladenylate synthase
A21D_RS04650	COG2890	protein-(glutamine-N5) methyltransferase activity
A21D_RS04655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A21D_RS04660	COG1435	thymidine kinase activity
A21D_RS04665	COG0254	rRNA binding
A21D_RS04670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A21D_RS04675	COG1494	fructose-1,6-bisphosphatase
A21D_RS04680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A21D_RS04685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A21D_RS04690	COG0191	fructose-bisphosphate aldolase activity
A21D_RS04700	COG0504	CTP synthase activity
A21D_RS04705	COG3343	RNA polymerase activity
A21D_RS04710	COG3226	Transcriptional regulator
A21D_RS04715	COG1960	acyl-CoA dehydrogenase activity
A21D_RS04720	COG1960	acyl-CoA dehydrogenase activity
A21D_RS04725	COG1250	3-hydroxyacyl-CoA dehydrogenase
A21D_RS04730	COG0183	Belongs to the thiolase family
A21D_RS04735	COG0247	lactate metabolic process
A21D_RS04735	COG2181	nitrate reductase activity
A21D_RS04740	COG1882	Formate acetyltransferase
A21D_RS04745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A21D_RS04750	COG0018	arginyl-trna synthetase
A21D_RS04760	COG5578	integral membrane protein
A21D_RS04765	COG0395	ABC-type sugar transport system, permease component
A21D_RS04770	COG4209	transmembrane transport
A21D_RS04775	COG1653	transport
A21D_RS04780	COG1653	transport
A21D_RS04785	COG0039	L-malate dehydrogenase activity
A21D_RS04790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A21D_RS04800	COG3465	dGTPase activity
A21D_RS04805	COG1078	dGTPase activity
A21D_RS04810	COG0095	Lipoate-protein ligase
A21D_RS04815	COG0280	phosphate acetyltransferase
A21D_RS04820	COG3253	May function as heme-dependent peroxidase
A21D_RS04825	COG3773	Cell wall hydrolase
A21D_RS04840	COG2363	Small membrane protein
A21D_RS04855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A21D_RS04860	COG3314	Sporulation integral membrane protein YlbJ
A21D_RS04865	COG3594	Acyltransferase
A21D_RS04870	COG3459	Glycosyltransferase 36 associated
A21D_RS04885	COG1175	transmembrane transport
A21D_RS04890	COG0395	ABC-type sugar transport system, permease component
A21D_RS04895	COG1609	Transcriptional regulator
A21D_RS04915	COG1309	transcriptional regulator
A21D_RS04925	COG1131	(ABC) transporter
A21D_RS04930	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_RS04945	COG0789	Transcriptional regulator
A21D_RS04955	COG1122	ATPase activity
A21D_RS04960	COG1122	ATPase activity
A21D_RS04975	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_RS04980	COG1268	BioY protein
A21D_RS04985	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A21D_RS04990	COG1960	acyl-CoA dehydrogenase activity
A21D_RS05000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A21D_RS05005	COG1280	lysine exporter protein (LysE YggA)
A21D_RS05010	COG0456	acetyltransferase
A21D_RS05015	COG1078	dGTPase activity
A21D_RS05025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_RS05040	COG0156	8-amino-7-oxononanoate synthase activity
A21D_RS05045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A21D_RS05050	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
A21D_RS05065	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A21D_RS05070	COG2169	Transcriptional regulator
A21D_RS05075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A21D_RS05080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A21D_RS05095	COG1917	Cupin 2, conserved barrel domain protein
A21D_RS05095	COG2207	Transcriptional regulator
A21D_RS05100	COG2207	Transcriptional regulator
A21D_RS05100	COG3708	Transcriptional regulator
A21D_RS05110	COG0583	DNA-binding transcription factor activity
A21D_RS05130	COG3739	integral membrane protein
A21D_RS05135	COG3655	Transcriptional regulator
A21D_RS05200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_RS05220	COG0384	phenazine biosynthesis protein PhzF
A21D_RS05225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A21D_RS05255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS05260	COG0698	ribose 5-phosphate isomerase
A21D_RS05270	COG1349	DNA-binding transcription factor activity
A21D_RS05285	COG0577	efflux transmembrane transporter activity
A21D_RS05290	COG5002	protein histidine kinase activity
A21D_RS05295	COG0745	RESPONSE REGULATOR receiver
A21D_RS05300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A21D_RS05310	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A21D_RS05315	COG5662	AntiSigma factor
A21D_RS05320	COG1595	DNA-templated transcription, initiation
A21D_RS05335	COG3842	ATPase activity
A21D_RS05350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A21D_RS05360	COG1796	DNA polymerase
A21D_RS05360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A21D_RS05375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A21D_RS05490	COG3677	Transposase
A21D_RS05505	COG2856	Zn peptidase
A21D_RS05510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A21D_RS05515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A21D_RS05515	COG0646	methionine synthase
A21D_RS05525	COG1131	(ABC) transporter
A21D_RS05535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A21D_RS05540	COG2217	Heavy metal translocating P-type atpase
A21D_RS05545	COG2217	Heavy metal translocating P-type atpase
A21D_RS05640	COG0726	polysaccharide deacetylase
A21D_RS05645	COG2194	sulfuric ester hydrolase activity
A21D_RS05655	COG0489	protein tyrosine kinase activity
A21D_RS05660	COG0860	N-Acetylmuramoyl-L-alanine amidase
A21D_RS05680	COG1295	ribonuclease BN
A21D_RS05695	COG4548	von Willebrand factor, type A
A21D_RS05700	COG0714	Associated with various cellular activities
A21D_RS05705	COG2130	NADP-dependent
A21D_RS05720	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A21D_RS05735	COG1349	DNA-binding transcription factor activity
A21D_RS05740	COG1979	alcohol dehydrogenase
A21D_RS05755	COG0385	Bile acid
A21D_RS05765	COG1840	ABC-type Fe3 transport system, periplasmic component
A21D_RS05770	COG3842	ATPase activity
A21D_RS05775	COG1178	ABC-type Fe3 transport system permease component
A21D_RS05785	COG0483	inositol monophosphate 1-phosphatase activity
A21D_RS05790	COG1609	Transcriptional regulator
A21D_RS05795	COG0492	ferredoxin-NADP+ reductase activity
A21D_RS05800	COG1120	ATPase activity
A21D_RS05805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A21D_RS05810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A21D_RS05815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A21D_RS05825	COG4509	Sortase family
A21D_RS05830	COG1120	ATPase activity
A21D_RS05845	COG5386	Cell surface protein
A21D_RS05850	COG5386	Cell surface protein
A21D_RS05855	COG5386	Cell surface protein
A21D_RS05860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A21D_RS05865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A21D_RS05875	COG2329	Antibiotic biosynthesis monooxygenase
A21D_RS05880	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A21D_RS05900	COG0583	DNA-binding transcription factor activity
A21D_RS05915	COG0280	phosphate acetyltransferase
A21D_RS05940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A21D_RS05995	COG1120	ATPase activity
A21D_RS06000	COG0477	Major facilitator Superfamily
A21D_RS06035	COG1129	ABC transporter
A21D_RS06050	COG1132	(ABC) transporter
A21D_RS06055	COG1132	(ABC) transporter
A21D_RS06055	COG2375	cellular response to nickel ion
A21D_RS06075	COG5504	Zn-dependent protease
A21D_RS06085	COG0577	efflux transmembrane transporter activity
A21D_RS06090	COG1136	(ABC) transporter
A21D_RS06095	COG2205	protein histidine kinase activity
A21D_RS06100	COG0745	RESPONSE REGULATOR receiver
A21D_RS06205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A21D_RS06210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A21D_RS06215	COG0101	tRNA pseudouridine synthase activity
A21D_RS06220	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A21D_RS06225	COG1122	ATPase activity
A21D_RS06230	COG1122	ATPase activity
A21D_RS06235	COG0203	ribosomal protein L17
A21D_RS06240	COG0202	RNA polymerase activity
A21D_RS06245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A21D_RS06250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A21D_RS06255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A21D_RS06260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A21D_RS06265	COG2163	COG2163 Ribosomal protein L14E L6E L27E
A21D_RS06270	COG0563	adenylate kinase activity
A21D_RS06275	COG0201	protein transport
A21D_RS06280	COG0200	Binds to the 23S rRNA
A21D_RS06285	COG1841	ribosomal large subunit assembly
A21D_RS06290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A21D_RS06295	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A21D_RS06300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A21D_RS06305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A21D_RS06310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A21D_RS06315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A21D_RS06320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A21D_RS06325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A21D_RS06330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A21D_RS06335	COG0255	Belongs to the universal ribosomal protein uL29 family
A21D_RS06340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A21D_RS06345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A21D_RS06350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A21D_RS06355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A21D_RS06360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A21D_RS06365	COG0089	rRNA binding
A21D_RS06370	COG0088	Forms part of the polypeptide exit tunnel
A21D_RS06375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A21D_RS06380	COG0051	transcription antitermination factor activity, RNA binding
A21D_RS06385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A21D_RS06390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A21D_RS06395	COG0049	tRNA binding
A21D_RS06400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A21D_RS06405	COG1358	cellular component organization or biogenesis
A21D_RS06410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A21D_RS06415	COG0085	RNA polymerase activity
A21D_RS06420	COG2813	Specifically methylates the guanine in position
A21D_RS06425	COG0222	ribosome binding
A21D_RS06430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A21D_RS06435	COG0081	regulation of translation
A21D_RS06440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A21D_RS06445	COG0250	Participates in transcription elongation, termination and antitermination
A21D_RS06450	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A21D_RS06455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A21D_RS06465	COG3688	RNA-binding protein containing a PIN domain
A21D_RS06470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A21D_RS06480	COG0215	cysteine-tRNA ligase activity
A21D_RS06485	COG1045	serine acetyltransferase
A21D_RS06490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A21D_RS06495	COG4956	integral membrane protein (PIN domain superfamily)
A21D_RS06500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A21D_RS06510	COG0542	response to heat
A21D_RS06515	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A21D_RS06520	COG3880	PFAM UvrB UvrC protein
A21D_RS06530	COG1285	pathogenesis
A21D_RS06615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A21D_RS06620	COG1396	sequence-specific DNA binding
A21D_RS06625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A21D_RS06630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A21D_RS06635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A21D_RS06640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A21D_RS06650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A21D_RS06655	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A21D_RS06660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A21D_RS06665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A21D_RS06670	COG0037	tRNA processing
A21D_RS06675	COG0515	serine threonine protein kinase
A21D_RS06680	COG2304	oxidoreductase activity
A21D_RS06685	COG2208	phosphoserine phosphatase activity
A21D_RS06695	COG1098	S1 RNA binding domain
A21D_RS06715	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A21D_RS06720	COG3956	TIGRFAM MazG family protein
A21D_RS06725	COG2244	polysaccharide biosynthetic process
A21D_RS06730	COG2002	toxin-antitoxin pair type II binding
A21D_RS06735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A21D_RS06745	COG0193	aminoacyl-tRNA hydrolase activity
A21D_RS06750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A21D_RS06755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A21D_RS06760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A21D_RS06765	COG2088	sporulation resulting in formation of a cellular spore
A21D_RS06770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A21D_RS06775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A21D_RS06785	COG4466	Protein conserved in bacteria
A21D_RS06795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A21D_RS06805	COG3583	domain protein
A21D_RS06805	COG3584	3D domain protein
A21D_RS06810	COG0084	hydrolase, TatD family'
A21D_RS06820	COG2002	toxin-antitoxin pair type II binding
A21D_RS06825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A21D_RS06830	COG2827	Endonuclease containing a URI domain
A21D_RS06835	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A21D_RS06840	COG4467	Involved in initiation control of chromosome replication
A21D_RS06845	COG1774	PSP1 C-terminal conserved region
A21D_RS06850	COG0470	DNA polymerase III
A21D_RS06855	COG1728	Protein conserved in bacteria
A21D_RS06860	COG3870	Protein conserved in bacteria
A21D_RS06865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A21D_RS06870	COG1982	Orn Lys Arg decarboxylase major
A21D_RS06890	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A21D_RS06895	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A21D_RS06900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A21D_RS06905	COG0288	reversible hydration of carbon dioxide
A21D_RS06915	COG0590	tRNA wobble adenosine to inosine editing
A21D_RS06920	COG1335	isochorismatase
A21D_RS06925	COG3858	chitin binding
A21D_RS06925	COG1388	LysM domain
A21D_RS06930	COG0693	protein deglycase activity
A21D_RS06935	COG1959	2 iron, 2 sulfur cluster binding
A21D_RS06940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A21D_RS06940	COG1017	nitric oxide dioxygenase activity
A21D_RS06965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A21D_RS06995	COG1301	dicarboxylic acid transport
A21D_RS07000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A21D_RS07010	COG1418	mRNA catabolic process
A21D_RS07030	COG0601	transmembrane transport
A21D_RS07035	COG4608	Belongs to the ABC transporter superfamily
A21D_RS07050	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A21D_RS07055	COG0745	RESPONSE REGULATOR receiver
A21D_RS07060	COG5002	protein histidine kinase activity
A21D_RS07070	COG1876	peptidase activity
A21D_RS07075	COG3103	Sh3 type 3 domain protein
A21D_RS07075	COG4991	sh3 domain protein
A21D_RS07075	COG0860	N-Acetylmuramoyl-L-alanine amidase
A21D_RS07090	COG1486	melibiose metabolic process
A21D_RS07095	COG1263	PTS System
A21D_RS07095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_RS07105	COG1737	Transcriptional regulator
A21D_RS07120	COG1428	Deoxynucleoside kinase
A21D_RS07125	COG1428	Deoxynucleoside kinase
A21D_RS07130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A21D_RS07150	COG1464	Belongs to the NlpA lipoprotein family
A21D_RS07155	COG2011	ABC-type metal ion transport system permease component
A21D_RS07160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A21D_RS07165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A21D_RS07170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A21D_RS07185	COG0517	IMP dehydrogenase activity
A21D_RS07185	COG0516	GMP reductase activity
A21D_RS07195	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A21D_RS07200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A21D_RS07205	COG0187	DNA topoisomerase II activity
A21D_RS07215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A21D_RS07220	COG2501	S4 domain
A21D_RS07225	COG0592	DNA-directed DNA polymerase activity
A21D_RS07230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A21D_RS07235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A21D_RS07240	COG0594	ribonuclease P activity
A21D_RS07245	COG0706	membrane insertase activity
A21D_RS07250	COG1847	R3H domain protein
A21D_RS07255	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A21D_RS07260	COG0445	tRNA wobble uridine modification
A21D_RS07265	COG0357	Ribosomal RNA small subunit methyltransferase G
A21D_RS07270	COG1475	DNA binding
A21D_RS07275	COG1192	Involved in chromosome partitioning
A21D_RS07280	COG1475	DNA binding
A21D_RS07300	COG3949	Membrane
A21D_RS07305	COG0668	transmembrane transport
A21D_RS07315	COG4481	Protein conserved in bacteria
A21D_RS07320	COG0012	GTP binding
A21D_RS07325	COG0360	Binds together with S18 to 16S ribosomal RNA
A21D_RS07330	COG0629	single-stranded DNA binding
A21D_RS07335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A21D_RS07340	COG0725	ABC transporter, periplasmic molybdate-binding protein
A21D_RS07350	COG4241	membrane
A21D_RS07355	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A21D_RS07360	COG0359	binds to the 23S rRNA
A21D_RS07365	COG0305	Participates in initiation and elongation during chromosome replication
A21D_RS07370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A21D_RS07380	COG0745	RESPONSE REGULATOR receiver
A21D_RS07385	COG5002	protein histidine kinase activity
A21D_RS07390	COG4863	YycH protein
A21D_RS07395	COG4853	Protein conserved in bacteria
A21D_RS07400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A21D_RS07405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A21D_RS07415	COG1132	(ABC) transporter
A21D_RS07420	COG0450	alkyl hydroperoxide reductase
A21D_RS07430	COG1309	transcriptional regulator
A21D_RS07435	COG2076	Multidrug Resistance protein
A21D_RS07440	COG2076	Multidrug Resistance protein
A21D_RS07445	COG0175	sulfate reduction
A21D_RS07450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A21D_RS07455	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A21D_RS07475	COG1587	Uroporphyrinogen-III synthase
A21D_RS07480	COG2046	Belongs to the sulfate adenylyltransferase family
A21D_RS07485	COG3273	potassium ion transport
A21D_RS07485	COG0471	metal ion transport
A21D_RS07490	COG0529	Catalyzes the synthesis of activated sulfate
A21D_RS07500	COG0406	alpha-ribazole phosphatase activity
A21D_RS07505	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_RS07520	COG2027	D-alanyl-D-alanine carboxypeptidase
A21D_RS07530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A21D_RS07550	COG1183	phosphatidylcholine synthase activity
A21D_RS07555	COG0688	phosphatidylethanolamine metabolic process
A21D_RS07560	COG0586	Pfam SNARE associated Golgi protein
A21D_RS07595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A21D_RS07645	COG3773	Cell wall hydrolase
A21D_RS07670	COG0494	nUDIX hydrolase
A21D_RS07680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A21D_RS07745	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A21D_RS07770	COG0745	RESPONSE REGULATOR receiver
A21D_RS07775	COG0642	Histidine kinase
A21D_RS07805	COG1131	(ABC) transporter
A21D_RS07835	COG3279	Response regulator of the LytR AlgR family
A21D_RS07845	COG1794	racemase activity, acting on amino acids and derivatives
A21D_RS07885	COG0726	polysaccharide deacetylase
A21D_RS07890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS07890	COG3711	transcriptional antiterminator
A21D_RS07900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS07900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS07900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS07905	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A21D_RS07910	COG3588	fructose-bisphosphate aldolase
A21D_RS07915	COG0179	Fumarylacetoacetate (FAA) hydrolase
A21D_RS07920	COG1131	(ABC) transporter
A21D_RS07925	COG2205	protein histidine kinase activity
A21D_RS07935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A21D_RS07940	COG0018	arginyl-trna synthetase
A21D_RS07950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A21D_RS07960	COG0549	Belongs to the carbamate kinase family
A21D_RS07970	COG0840	transmembrane signaling receptor activity
A21D_RS07980	COG0477	Major facilitator Superfamily
A21D_RS07985	COG1174	glycine betaine transport
A21D_RS07990	COG1732	Glycine betaine
A21D_RS07995	COG1174	glycine betaine transport
A21D_RS08000	COG1125	glycine betaine transport
A21D_RS08000	COG0517	IMP dehydrogenase activity
A21D_RS08005	COG1510	regulation of RNA biosynthetic process
A21D_RS08015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_RS08015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_RS08020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS08020	COG3711	transcriptional antiterminator
A21D_RS08025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_RS08030	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_RS08040	COG1760	l-serine dehydratase
A21D_RS08045	COG1760	l-serine dehydratase
A21D_RS08055	COG1760	l-serine dehydratase
A21D_RS08060	COG1760	l-serine dehydratase
A21D_RS08065	COG0814	amino acid
A21D_RS08070	COG1486	melibiose metabolic process
A21D_RS08075	COG2814	Major facilitator Superfamily
A21D_RS08080	COG5577	PFAM Coat F domain
A21D_RS08090	COG1113	amino acid transport
A21D_RS08095	COG3403	YqcI/YcgG family
A21D_RS08100	COG1280	lysine exporter protein (LysE YggA)
A21D_RS08115	COG0546	phosphoglycolate phosphatase activity
A21D_RS08120	COG2116	formate transmembrane transporter activity
A21D_RS08125	COG3428	Bacterial PH domain
A21D_RS08145	COG0583	DNA-binding transcription factor activity
A21D_RS08155	COG0110	maltose O-acetyltransferase activity
A21D_RS08165	COG2188	Transcriptional regulator
A21D_RS08170	COG1482	cell wall glycoprotein biosynthetic process
A21D_RS08175	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS08175	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_RS08190	COG3716	PTS system mannose fructose sorbose family IID component
A21D_RS08200	COG0471	metal ion transport
A21D_RS08205	COG4565	transcriptional regulatory protein
A21D_RS08210	COG3290	protein histidine kinase activity
A21D_RS08235	COG3627	carbon phosphorus lyase activity
A21D_RS08240	COG4107	phosphonate C-P lyase system protein PhnK
A21D_RS08245	COG3454	Phosphonate metabolism
A21D_RS08250	COG4778	phosphonate C-P lyase system protein PhnL
A21D_RS08255	COG0613	PHP domain protein
A21D_RS08265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A21D_RS08270	COG3639	organic phosphonate transmembrane transporter activity
A21D_RS08275	COG3639	organic phosphonate transmembrane transporter activity
A21D_RS08285	COG2766	serine protein kinase
A21D_RS08290	COG2718	Belongs to the UPF0229 family
A21D_RS08300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A21D_RS08305	COG1321	iron dependent repressor
A21D_RS08305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A21D_RS08310	COG1121	(ABC) transporter
A21D_RS08315	COG0803	Belongs to the bacterial solute-binding protein 9 family
A21D_RS08320	COG2719	SpoVR family
A21D_RS08330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A21D_RS08335	COG3949	Membrane
A21D_RS08345	COG4536	flavin adenine dinucleotide binding
A21D_RS08350	COG1937	Protein conserved in bacteria
A21D_RS08355	COG0640	Transcriptional regulator
A21D_RS08360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A21D_RS08365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A21D_RS08370	COG5002	protein histidine kinase activity
A21D_RS08375	COG0745	RESPONSE REGULATOR receiver
A21D_RS08380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_RS08385	COG0785	Cytochrome C biogenesis protein
A21D_RS08405	COG0583	DNA-binding transcription factor activity
A21D_RS08410	COG1607	acyl-coa hydrolase
A21D_RS08430	COG2188	Transcriptional regulator
A21D_RS08435	COG4821	SIS domain
A21D_RS08450	COG3711	transcriptional antiterminator
A21D_RS08455	COG2190	(PTS) system
A21D_RS08460	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A21D_RS08465	COG1131	(ABC) transporter
A21D_RS08470	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A21D_RS08475	COG1131	(ABC) transporter
A21D_RS08495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A21D_RS08500	COG0800	Aldolase
A21D_RS08505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A21D_RS08520	COG3871	stress protein (general stress protein 26)
A21D_RS08525	COG1136	(ABC) transporter
A21D_RS08530	COG0577	efflux transmembrane transporter activity
A21D_RS08535	COG1011	Hydrolase
A21D_RS08540	COG0346	lactoylglutathione lyase activity
A21D_RS08550	COG1105	Belongs to the carbohydrate kinase PfkB family
A21D_RS08555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS08555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS08555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS08560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS08560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS08560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS08570	COG0561	phosphatase activity
A21D_RS08590	COG1063	alcohol dehydrogenase
A21D_RS08595	COG0840	transmembrane signaling receptor activity
A21D_RS08600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A21D_RS08605	COG0581	inorganic phosphate transmembrane transporter activity
A21D_RS08610	COG0573	inorganic phosphate transmembrane transporter activity
A21D_RS08615	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A21D_RS08630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A21D_RS08635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A21D_RS08655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A21D_RS08680	COG0137	argininosuccinate synthase activity
A21D_RS08690	COG1346	cytolysis
A21D_RS08700	COG1252	NADH dehydrogenase
A21D_RS08715	COG0427	acetyl-CoA hydrolase
A21D_RS08720	COG0131	Imidazoleglycerol-phosphate dehydratase
A21D_RS08720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A21D_RS08725	COG0501	Belongs to the peptidase M48B family
A21D_RS08730	COG0655	NAD(P)H dehydrogenase (quinone) activity
A21D_RS08755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A21D_RS08760	COG0069	glutamate synthase activity
A21D_RS08760	COG0070	glutamate synthase
A21D_RS08760	COG0067	glutamate synthase
A21D_RS08765	COG0493	'glutamate synthase
A21D_RS08770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A21D_RS08790	COG0753	catalase activity
A21D_RS08795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A21D_RS08800	COG3383	formate dehydrogenase (NAD+) activity
A21D_RS08805	COG2323	membrane
A21D_RS08810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A21D_RS08820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A21D_RS08830	COG1136	(ABC) transporter
A21D_RS08845	COG2226	methyltransferase
A21D_RS08850	COG4991	sh3 domain protein
A21D_RS08850	COG3103	Sh3 type 3 domain protein
A21D_RS08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
A21D_RS08855	COG0655	NAD(P)H dehydrogenase (quinone) activity
A21D_RS08870	COG4152	abc transporter atp-binding protein
A21D_RS08875	COG4604	ABC transporter, ATP-binding protein
A21D_RS08880	COG2188	Transcriptional regulator
A21D_RS08905	COG2032	superoxide dismutase activity
A21D_RS08910	COG1070	Carbohydrate kinase
A21D_RS08915	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A21D_RS08920	COG1737	Transcriptional regulator
A21D_RS08930	COG1263	PTS System
A21D_RS08930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_RS08940	COG2814	Major facilitator Superfamily
A21D_RS08950	COG1136	(ABC) transporter
A21D_RS08955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A21D_RS08970	COG2070	2-Nitropropane dioxygenase
A21D_RS08975	COG2358	TRAP transporter, solute receptor (TAXI family
A21D_RS09005	COG0791	NLP P60 protein
A21D_RS09005	COG0741	lytic transglycosylase activity
A21D_RS09010	COG0251	oxidation-reduction process
A21D_RS09020	COG0534	Mate efflux family protein
A21D_RS09025	COG2814	Major facilitator Superfamily
A21D_RS09035	COG3584	3D domain protein
A21D_RS09035	COG1388	LysM domain
A21D_RS09040	COG1131	(ABC) transporter
A21D_RS09045	COG0842	Transport permease protein
A21D_RS09050	COG4585	Histidine kinase
A21D_RS09055	COG2197	response regulator
A21D_RS09060	COG0156	8-amino-7-oxononanoate synthase activity
A21D_RS09065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A21D_RS09070	COG0488	(ABC) transporter
A21D_RS09085	COG2755	lipolytic protein G-D-S-L family
A21D_RS09090	COG2873	o-acetylhomoserine
A21D_RS09095	COG2962	Rard protein
A21D_RS09100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A21D_RS09105	COG1607	acyl-coa hydrolase
A21D_RS09110	COG1115	amino acid carrier protein
A21D_RS09115	COG1733	regulation of RNA biosynthetic process
A21D_RS09125	COG0514	ATP-dependent DNA helicase (RecQ)
A21D_RS09135	COG1114	Component of the transport system for branched-chain amino acids
A21D_RS09155	COG0628	permease
A21D_RS09160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A21D_RS09165	COG0861	Integral membrane protein TerC family
A21D_RS09185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A21D_RS09190	COG3285	dna ligase
A21D_RS09190	COG1793	dna ligase
A21D_RS09200	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A21D_RS09205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A21D_RS09215	COG0583	DNA-binding transcription factor activity
A21D_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_RS09230	COG4670	ketone body catabolic process
A21D_RS09240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A21D_RS09250	COG1595	DNA-templated transcription, initiation
A21D_RS09260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A21D_RS09265	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A21D_RS09270	COG0746	molybdenum cofactor guanylyltransferase activity
A21D_RS09275	COG0521	Mo-molybdopterin cofactor biosynthetic process
A21D_RS09280	COG0725	ABC transporter, periplasmic molybdate-binding protein
A21D_RS09285	COG4149	molybdate abc transporter
A21D_RS09315	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A21D_RS09320	COG0626	cystathionine gamma-synthase activity
A21D_RS09325	COG3457	Alanine racemase
A21D_RS09330	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A21D_RS09335	COG0315	cyclic pyranopterin monophosphate synthase activity
A21D_RS09355	COG0789	Transcriptional regulator
A21D_RS09365	COG0662	Cupin 2, conserved barrel domain protein
A21D_RS09370	COG3634	alkyl hydroperoxide reductase activity
A21D_RS09375	COG0450	alkyl hydroperoxide reductase
A21D_RS09380	COG1115	amino acid carrier protein
A21D_RS09385	COG4187	Peptidase family M20/M25/M40
A21D_RS09395	COG2723	6-phospho-beta-galactosidase activity
A21D_RS09400	COG1940	carbohydrate kinase activity
A21D_RS09410	COG0383	alpha-mannosidase activity
A21D_RS09415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS09415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS09415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS09420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS09420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS09420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS09425	COG0671	phosphoesterase, PA-phosphatase related
A21D_RS09435	COG0772	Belongs to the SEDS family
A21D_RS09440	COG0772	Belongs to the SEDS family
A21D_RS09450	COG0456	acetyltransferase
A21D_RS09455	COG0590	tRNA wobble adenosine to inosine editing
A21D_RS09475	COG3414	Phosphotransferase system galactitol-specific IIB component
A21D_RS09480	COG3775	system Galactitol-specific IIC component
A21D_RS09500	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_RS09555	COG0109	protoheme IX farnesyltransferase activity
A21D_RS09560	COG1253	flavin adenine dinucleotide binding
A21D_RS09565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A21D_RS09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_RS09575	COG2226	methyltransferase
A21D_RS09580	COG1328	CTP reductase activity
A21D_RS09600	COG1801	Protein of unknown function DUF72
A21D_RS09615	COG0366	Alpha amylase catalytic
A21D_RS09620	COG1609	Transcriptional regulator
A21D_RS09635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A21D_RS09640	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A21D_RS09645	COG3766	membrane
A21D_RS09655	COG1842	Phage shock protein A
A21D_RS09675	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A21D_RS09680	COG1122	ATPase activity
A21D_RS09685	COG4721	ABC-type cobalt transport system, permease component
A21D_RS09695	COG0579	oxidoreductase
A21D_RS09700	COG4565	transcriptional regulatory protein
A21D_RS09705	COG2358	TRAP transporter, solute receptor (TAXI family
A21D_RS09750	COG0833	amino acid
A21D_RS09755	COG1802	Transcriptional regulator
A21D_RS09760	COG1802	Transcriptional regulator
A21D_RS09775	COG1757	Na H antiporter
A21D_RS09780	COG0488	(ABC) transporter
A21D_RS09790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A21D_RS09815	COG1217	gtp-binding protein TYPA
A21D_RS09830	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A21D_RS09835	COG1131	(ABC) transporter
A21D_RS09865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_RS09875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_RS09880	COG0745	RESPONSE REGULATOR receiver
A21D_RS09885	COG3850	Histidine kinase
A21D_RS09885	COG5002	protein histidine kinase activity
A21D_RS09905	COG0737	Belongs to the 5'-nucleotidase family
A21D_RS09910	COG3639	organic phosphonate transmembrane transporter activity
A21D_RS09915	COG3639	organic phosphonate transmembrane transporter activity
A21D_RS09920	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A21D_RS09930	COG1597	lipid kinase activity
A21D_RS09935	COG4152	abc transporter atp-binding protein
A21D_RS09945	COG1846	Transcriptional regulator
A21D_RS09970	COG0697	spore germination
A21D_RS09975	COG0513	Belongs to the DEAD box helicase family
A21D_RS09980	COG3402	PFAM membrane-flanked domain
A21D_RS09985	COG3428	Bacterial PH domain
A21D_RS09995	COG0705	Rhomboid family
A21D_RS10000	COG0736	holo-[acyl-carrier-protein] synthase activity
A21D_RS10010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A21D_RS10025	COG2337	Toxic component of a toxin-antitoxin (TA) module
A21D_RS10030	COG1366	Belongs to the anti-sigma-factor antagonist family
A21D_RS10035	COG1366	Belongs to the anti-sigma-factor antagonist family
A21D_RS10040	COG2172	sigma factor antagonist activity
A21D_RS10045	COG2208	phosphoserine phosphatase activity
A21D_RS10050	COG1366	Belongs to the anti-sigma-factor antagonist family
A21D_RS10055	COG2172	sigma factor antagonist activity
A21D_RS10060	COG1191	sigma factor activity
A21D_RS10065	COG2208	phosphoserine phosphatase activity
A21D_RS10070	COG2183	response to ionizing radiation
A21D_RS10075	COG0753	catalase activity
A21D_RS10080	COG3091	SprT-like family
A21D_RS10170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A21D_RS10175	COG0802	atpase or kinase
A21D_RS10180	COG1214	PFAM Peptidase M22, glycoprotease
A21D_RS10185	COG0456	acetyltransferase
A21D_RS10190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A21D_RS10195	COG0772	Belongs to the SEDS family
A21D_RS10200	COG0488	(ABC) transporter
A21D_RS10205	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A21D_RS10215	COG1266	CAAX protease self-immunity
A21D_RS10220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A21D_RS10225	COG0459	protein refolding
A21D_RS10230	COG0582	viral genome integration into host DNA
A21D_RS10235	COG2856	Zn peptidase
A21D_RS10290	COG5377	YqaJ viral recombinase family
A21D_RS10295	COG3723	Recombinational DNA repair protein, rece pathway
A21D_RS10310	COG3331	DNA recombination
A21D_RS10370	COG5484	DNA packaging
A21D_RS10370	COG3728	DNA packaging
A21D_RS10375	COG1783	phage Terminase large subunit
A21D_RS10380	COG5518	Phage portal protein
A21D_RS10385	COG2369	cell adhesion
A21D_RS10395	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A21D_RS10400	COG4653	Phage capsid family
A21D_RS10450	COG3953	SLT domain
A21D_RS10450	COG5280	Phage tail tape measure protein TP901
A21D_RS10450	COG5280	Phage tail tape measure protein TP901
A21D_RS10450	COG3953	SLT domain
A21D_RS10455	COG1652	LysM domain
A21D_RS10460	COG4193	domain, Protein
A21D_RS10470	COG3628	GPW Gp25 family protein
A21D_RS10475	COG3299	homolog of phage Mu protein gp47
A21D_RS10495	COG4824	toxin secretion phage lysis holin
A21D_RS10500	COG5632	N-Acetylmuramoyl-L-alanine amidase
A21D_RS10500	COG3409	Peptidoglycan-binding domain 1 protein
A21D_RS10525	COG0464	growth
A21D_RS10550	COG4974	Belongs to the 'phage' integrase family
A21D_RS10570	COG1115	amino acid carrier protein
A21D_RS10580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_RS10610	COG1966	Carbon starvation protein
A21D_RS10620	COG0747	negative chemotaxis
A21D_RS10630	COG4608	Belongs to the ABC transporter superfamily
A21D_RS10635	COG0444	Belongs to the ABC transporter superfamily
A21D_RS10640	COG0601	transmembrane transport
A21D_RS10645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A21D_RS10650	COG0747	negative chemotaxis
A21D_RS10660	COG1609	Transcriptional regulator
A21D_RS10665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A21D_RS10670	COG1869	D-ribose catabolic process
A21D_RS10680	COG1172	Belongs to the binding-protein-dependent transport system permease family
A21D_RS10685	COG1879	ABC-type sugar transport system periplasmic component
A21D_RS10695	COG1473	amidohydrolase
A21D_RS10700	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A21D_RS10705	COG1473	amidohydrolase
A21D_RS10710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A21D_RS10715	COG1757	Na H antiporter
A21D_RS10725	COG0561	phosphatase activity
A21D_RS10730	COG2723	6-phospho-beta-galactosidase activity
A21D_RS10735	COG2190	(PTS) system
A21D_RS10735	COG1263	PTS System
A21D_RS10735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_RS10745	COG1442	glycosyl transferase family 8
A21D_RS10750	COG0071	Belongs to the small heat shock protein (HSP20) family
A21D_RS10760	COG1454	alcohol dehydrogenase
A21D_RS10765	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS10770	COG1510	regulation of RNA biosynthetic process
A21D_RS10780	COG2200	EAL domain
A21D_RS10790	COG0840	transmembrane signaling receptor activity
A21D_RS10795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A21D_RS10800	COG0601	transmembrane transport
A21D_RS10810	COG4608	Belongs to the ABC transporter superfamily
A21D_RS10815	COG0444	Belongs to the ABC transporter superfamily
A21D_RS10830	COG0697	spore germination
A21D_RS10835	COG0531	amino acid
A21D_RS10845	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A21D_RS10850	COG0714	Associated with various cellular activities
A21D_RS10855	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A21D_RS10860	COG1305	Transglutaminase-like
A21D_RS10865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A21D_RS10865	COG0519	Catalyzes the synthesis of GMP from XMP
A21D_RS10870	COG2217	Heavy metal translocating P-type atpase
A21D_RS10875	COG0640	Transcriptional regulator
A21D_RS10880	COG0803	Belongs to the bacterial solute-binding protein 9 family
A21D_RS10885	COG2252	PERMEase
A21D_RS10900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A21D_RS10905	COG2258	MOSC domain
A21D_RS10915	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A21D_RS10920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A21D_RS10925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A21D_RS10930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A21D_RS10935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A21D_RS10940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A21D_RS10945	COG0047	phosphoribosylformylglycinamidine synthase activity
A21D_RS10950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A21D_RS10955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A21D_RS10960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A21D_RS10965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A21D_RS10970	COG0138	bifunctional purine biosynthesis protein purh
A21D_RS10975	COG0151	Belongs to the GarS family
A21D_RS10980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A21D_RS10985	COG1470	cell adhesion involved in biofilm formation
A21D_RS10990	COG4496	protein, YerC YecD
A21D_RS10995	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A21D_RS11000	COG0210	DNA helicase
A21D_RS11005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A21D_RS11010	COG4851	CamS sex pheromone cAM373 precursor
A21D_RS11020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A21D_RS11025	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A21D_RS11030	COG0154	amidase activity
A21D_RS11035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A21D_RS11040	COG1597	lipid kinase activity
A21D_RS11045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A21D_RS11060	COG0583	DNA-binding transcription factor activity
A21D_RS11070	COG1960	acyl-CoA dehydrogenase activity
A21D_RS11075	COG0372	Belongs to the citrate synthase family
A21D_RS11080	COG0730	response to heat
A21D_RS11085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A21D_RS11090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A21D_RS11105	COG3655	Transcriptional regulator
A21D_RS11110	COG0702	epimerase
A21D_RS11115	COG0531	amino acid
A21D_RS11125	COG0351	phosphomethylpyrimidine kinase
A21D_RS11130	COG1757	Na H antiporter
A21D_RS11135	COG4496	protein, YerC YecD
A21D_RS11150	COG1695	Transcriptional regulator
A21D_RS11170	COG0626	cystathionine gamma-synthase activity
A21D_RS11175	COG3546	catalase activity
A21D_RS11185	COG0583	DNA-binding transcription factor activity
A21D_RS11190	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A21D_RS11200	COG2814	Major facilitator Superfamily
A21D_RS11205	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A21D_RS11210	COG2610	gluconate transmembrane transporter activity
A21D_RS11220	COG0583	DNA-binding transcription factor activity
A21D_RS11225	COG0372	Belongs to the citrate synthase family
A21D_RS11230	COG2079	MmgE PrpD family protein
A21D_RS11235	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A21D_RS11250	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A21D_RS11250	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A21D_RS11265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_RS11270	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_RS11280	COG1695	Transcriptional regulator
A21D_RS11290	COG1619	proteins homologs of microcin C7 resistance protein MccF
A21D_RS11295	COG0166	Belongs to the GPI family
A21D_RS11300	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS11315	COG3835	regulator
A21D_RS11320	COG0277	FAD linked oxidase domain protein
A21D_RS11325	COG0247	lactate metabolic process
A21D_RS11330	COG1937	Protein conserved in bacteria
A21D_RS11335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_RS11345	COG2210	Belongs to the sulfur carrier protein TusA family
A21D_RS11350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_RS11355	COG0425	Belongs to the sulfur carrier protein TusA family
A21D_RS11355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_RS11360	COG2210	Belongs to the sulfur carrier protein TusA family
A21D_RS11365	COG0425	Belongs to the sulfur carrier protein TusA family
A21D_RS11375	COG0288	reversible hydration of carbon dioxide
A21D_RS11380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_RS11380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_RS11385	COG0840	transmembrane signaling receptor activity
A21D_RS11395	COG0307	riboflavin synthase, alpha
A21D_RS11400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A21D_RS11400	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A21D_RS11415	COG0488	(ABC) transporter
A21D_RS11450	COG0446	pyridine nucleotide-disulphide oxidoreductase
A21D_RS11455	COG0733	neurotransmitter:sodium symporter activity
A21D_RS11465	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A21D_RS11470	COG3844	kynureninase activity
A21D_RS11475	COG1757	Na H antiporter
A21D_RS11480	COG0436	Aminotransferase
A21D_RS11485	COG0028	Belongs to the TPP enzyme family
A21D_RS11490	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS11510	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS11515	COG1960	acyl-CoA dehydrogenase activity
A21D_RS11520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A21D_RS11525	COG1077	Cell shape determining protein MreB Mrl
A21D_RS11530	COG2340	Cysteine-rich secretory protein family
A21D_RS11540	COG2066	Belongs to the glutaminase family
A21D_RS11545	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A21D_RS11555	COG1295	ribonuclease BN
A21D_RS11560	COG2217	Heavy metal translocating P-type atpase
A21D_RS11565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A21D_RS11570	COG0765	amino acid transport
A21D_RS11580	COG0477	Major facilitator Superfamily
A21D_RS11595	COG2056	Na+-H+ antiporter family
A21D_RS11605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A21D_RS11610	COG0542	response to heat
A21D_RS11630	COG1725	Transcriptional regulator
A21D_RS11635	COG1131	(ABC) transporter
A21D_RS11645	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A21D_RS11650	COG1131	(ABC) transporter
A21D_RS11655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A21D_RS11665	COG1725	Transcriptional regulator
A21D_RS11670	COG1396	sequence-specific DNA binding
A21D_RS11680	COG1090	epimerase
A21D_RS11685	COG2137	regulation of response to DNA damage stimulus
A21D_RS11695	COG1988	membrane-bound metal-dependent
A21D_RS11700	COG1194	a g-specific adenine glycosylase
A21D_RS11710	COG3557	Belongs to the UPF0374 family
A21D_RS11715	COG1132	(ABC) transporter
A21D_RS11725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A21D_RS11730	COG0577	efflux transmembrane transporter activity
A21D_RS11735	COG1136	(ABC) transporter
A21D_RS11740	COG2205	protein histidine kinase activity
A21D_RS11745	COG0745	RESPONSE REGULATOR receiver
A21D_RS11755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A21D_RS11760	COG2096	Adenosyltransferase
A21D_RS11765	COG0735	belongs to the Fur family
A21D_RS11880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A21D_RS11900	COG4533	DNA binding
A21D_RS11920	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A21D_RS11940	COG1509	lysine 2,3-aminomutase activity
A21D_RS11950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A21D_RS11970	COG0653	protein targeting
A21D_RS11985	COG1408	metallophosphoesterase
A21D_RS11995	COG0384	phenazine biosynthesis protein PhzF
A21D_RS12005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A21D_RS12010	COG0402	S-adenosylhomocysteine deaminase activity
A21D_RS12015	COG3775	system Galactitol-specific IIC component
A21D_RS12020	COG3414	Phosphotransferase system galactitol-specific IIB component
A21D_RS12025	COG1999	signal sequence binding
A21D_RS12030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A21D_RS12045	COG0352	thiamine-phosphate diphosphorylase activity
A21D_RS12050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A21D_RS12060	COG2022	thiamine diphosphate biosynthetic process
A21D_RS12065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A21D_RS12075	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A21D_RS12100	COG5002	protein histidine kinase activity
A21D_RS12105	COG0745	RESPONSE REGULATOR receiver
A21D_RS12130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A21D_RS12135	COG0583	DNA-binding transcription factor activity
A21D_RS12145	COG3764	Sortase (surface protein transpeptidase)
A21D_RS12150	COG0436	Aminotransferase
A21D_RS12155	COG1309	transcriptional regulator
A21D_RS12170	COG0183	Belongs to the thiolase family
A21D_RS12180	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_RS12185	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_RS12210	COG2233	PERMEase
A21D_RS12225	COG1063	alcohol dehydrogenase
A21D_RS12230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A21D_RS12240	COG2706	6-phosphogluconolactonase activity
A21D_RS12245	COG0028	Belongs to the TPP enzyme family
A21D_RS12290	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A21D_RS12300	COG4821	SIS domain
A21D_RS12305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A21D_RS12315	COG1234	tRNA 3'-trailer cleavage
A21D_RS12330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A21D_RS12335	COG0444	Belongs to the ABC transporter superfamily
A21D_RS12340	COG4608	Belongs to the ABC transporter superfamily
A21D_RS12345	COG2814	Major facilitator Superfamily
A21D_RS12350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A21D_RS12360	COG1473	amidohydrolase
A21D_RS12365	COG1288	antiporter activity
A21D_RS12370	COG4948	Mandelate Racemase Muconate Lactonizing
A21D_RS12380	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A21D_RS12385	COG3711	transcriptional antiterminator
A21D_RS12390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_RS12390	COG1263	PTS System
A21D_RS12390	COG2190	(PTS) system
A21D_RS12395	COG1486	melibiose metabolic process
A21D_RS12400	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS12405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_RS12410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A21D_RS12415	COG1447	Phosphotransferase system cellobiose-specific component IIA
A21D_RS12420	COG2723	6-phospho-beta-galactosidase activity
A21D_RS12425	COG3711	transcriptional antiterminator
A21D_RS12425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS12430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS12430	COG3711	transcriptional antiterminator
A21D_RS12435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS12435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A21D_RS12435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS12440	COG1482	cell wall glycoprotein biosynthetic process
A21D_RS12445	COG0656	L-ascorbic acid biosynthetic process
A21D_RS12460	COG0326	Molecular chaperone. Has ATPase activity
A21D_RS12475	COG1116	anion transmembrane transporter activity
A21D_RS12480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A21D_RS12485	COG1011	Hydrolase
A21D_RS12495	COG1757	Na H antiporter
A21D_RS12500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A21D_RS12505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A21D_RS12520	COG2176	DNA-directed DNA polymerase activity
A21D_RS12540	COG3314	Sporulation integral membrane protein YlbJ
A21D_RS12550	COG1960	acyl-CoA dehydrogenase activity
A21D_RS12560	COG0010	Belongs to the arginase family
A21D_RS12565	COG1228	amidohydrolase
A21D_RS12575	COG2986	histidine ammonia-lyase
A21D_RS12585	COG2070	2-Nitropropane dioxygenase
A21D_RS12590	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_RS12595	COG0583	DNA-binding transcription factor activity
A21D_RS12600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A21D_RS12605	COG1473	amidohydrolase
A21D_RS12610	COG2365	Tyrosine phosphatase family
A21D_RS12615	COG3829	transcription factor binding
A21D_RS12615	COG3290	protein histidine kinase activity
A21D_RS12625	COG1960	acyl-CoA dehydrogenase activity
A21D_RS12635	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS12645	COG1024	Enoyl-CoA hydratase
A21D_RS12660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A21D_RS12670	COG2190	(PTS) system
A21D_RS12670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_RS12670	COG1263	PTS System
A21D_RS12680	COG0366	Alpha amylase catalytic
A21D_RS12695	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS12700	COG0506	proline dehydrogenase activity
A21D_RS12715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A21D_RS12720	COG2233	PERMEase
A21D_RS12725	COG2814	Major facilitator Superfamily
A21D_RS12735	COG0604	alcohol dehydrogenase
A21D_RS12750	COG4585	Histidine kinase
A21D_RS12755	COG2197	response regulator
A21D_RS12760	COG1131	(ABC) transporter
A21D_RS12790	COG0505	Belongs to the CarA family
A21D_RS12800	COG4946	Tricorn protease homolog
A21D_RS12800	COG1506	peptidase
A21D_RS12800	COG0823	Involved in the tonB-independent uptake of proteins
A21D_RS12810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A21D_RS12840	COG0567	Dehydrogenase, E1 component
A21D_RS12845	COG0508	dehydrogenase complex catalyzes the overall conversion of
A21D_RS12850	COG3344	reverse transcriptase
A21D_RS12855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A21D_RS12860	COG0534	Mate efflux family protein
A21D_RS12865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A21D_RS12870	COG1132	(ABC) transporter
A21D_RS12875	COG1132	(ABC) transporter
A21D_RS12880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A21D_RS12885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_RS12900	COG1191	sigma factor activity
A21D_RS12925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A21D_RS12930	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_RS12940	COG0024	Methionine aminopeptidase
A21D_RS12945	COG1757	Na H antiporter
A21D_RS12960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A21D_RS12985	COG2270	Major facilitator Superfamily
A21D_RS12995	COG0114	fumarate hydratase activity
A21D_RS13005	COG3842	ATPase activity
A21D_RS13010	COG2508	Transcriptional regulator
A21D_RS13015	COG3679	Belongs to the UPF0342 family
A21D_RS13020	COG1024	Enoyl-CoA hydratase
A21D_RS13040	COG4152	abc transporter atp-binding protein
A21D_RS13045	COG1668	transmembrane transport
A21D_RS13050	COG0420	3'-5' exonuclease activity
A21D_RS13055	COG4717	serine-type aminopeptidase activity
A21D_RS13060	COG1510	regulation of RNA biosynthetic process
A21D_RS13075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A21D_RS13095	COG1510	regulation of RNA biosynthetic process
A21D_RS13100	COG0517	IMP dehydrogenase activity
A21D_RS13100	COG4175	Glycine betaine
A21D_RS13130	COG0537	adenosine 5'-monophosphoramidase activity
A21D_RS13135	COG1609	Transcriptional regulator
A21D_RS13140	COG3069	C4-dicarboxylate transmembrane transporter activity
A21D_RS13150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A21D_RS13155	COG1131	(ABC) transporter
A21D_RS13160	COG4473	ABC transporter
A21D_RS13165	COG1473	amidohydrolase
A21D_RS13180	COG2814	Major facilitator Superfamily
A21D_RS13190	COG4585	Histidine kinase
A21D_RS13195	COG2197	response regulator
A21D_RS13200	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A21D_RS13205	COG0492	ferredoxin-NADP+ reductase activity
A21D_RS13205	COG3118	belongs to the thioredoxin family
A21D_RS13220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A21D_RS13225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A21D_RS13230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A21D_RS13235	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A21D_RS13240	COG1164	Oligoendopeptidase f
A21D_RS13250	COG0095	Lipoate-protein ligase
A21D_RS13255	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_RS13275	COG0398	Pfam SNARE associated Golgi protein
A21D_RS13285	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A21D_RS13290	COG1074	ATP-dependent DNA helicase activity
A21D_RS13325	COG2311	Membrane
A21D_RS13330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A21D_RS13350	COG1307	EDD domain protein, DegV family
A21D_RS13355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A21D_RS13375	COG0561	phosphatase activity
A21D_RS13380	COG1073	alpha beta
A21D_RS13385	COG2151	metal-sulfur cluster biosynthetic enzyme
A21D_RS13410	COG1744	ABC transporter substrate-binding protein PnrA-like
A21D_RS13415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A21D_RS13420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A21D_RS13435	COG0180	Tryptophanyl-tRNA synthetase
A21D_RS13440	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A21D_RS13445	COG0709	Synthesizes selenophosphate from selenide and ATP
A21D_RS13460	COG0456	acetyltransferase
A21D_RS13470	COG1393	Belongs to the ArsC family
A21D_RS13475	COG4862	establishment of competence for transformation
A21D_RS13485	COG1164	Oligoendopeptidase f
A21D_RS13495	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A21D_RS13500	COG2346	COG2346, Truncated hemoglobins
A21D_RS13505	COG4116	CYTH
A21D_RS13510	COG2357	RelA SpoT domain protein
A21D_RS13515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A21D_RS13520	COG0564	pseudouridine synthase activity
A21D_RS13525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A21D_RS13530	COG2239	Acts as a magnesium transporter
A21D_RS13560	COG2323	membrane
A21D_RS13565	COG2153	protein acetylation
A21D_RS13570	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A21D_RS13575	COG2382	esterase
A21D_RS13580	COG1132	(ABC) transporter
A21D_RS13585	COG1132	(ABC) transporter
A21D_RS13595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A21D_RS13605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A21D_RS13610	COG4565	transcriptional regulatory protein
A21D_RS13615	COG3290	protein histidine kinase activity
A21D_RS13635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A21D_RS13735	COG0248	Ppx GppA phosphatase
A21D_RS13750	COG0745	RESPONSE REGULATOR receiver
A21D_RS13750	COG2972	Histidine kinase
A21D_RS13755	COG3279	Response regulator of the LytR AlgR family
A21D_RS13800	COG0826	peptidase U32
A21D_RS13810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS13825	COG0159	tryptophan synthase activity
A21D_RS13830	COG0589	response to stress
A21D_RS13835	COG3258	Cytochrome c
A21D_RS13840	COG0730	response to heat
A21D_RS13845	COG0737	Belongs to the 5'-nucleotidase family
A21D_RS13855	COG1757	Na H antiporter
A21D_RS13860	COG0733	neurotransmitter:sodium symporter activity
A21D_RS13870	COG0739	heme binding
A21D_RS13880	COG4470	Protein conserved in bacteria
A21D_RS13895	COG2445	Protein of unknown function DUF86
A21D_RS13900	COG0647	UMP catabolic process
A21D_RS13905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A21D_RS13910	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A21D_RS13920	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A21D_RS13925	COG4837	Protein of unknown function (DUF1462)
A21D_RS13930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A21D_RS13935	COG0316	Belongs to the HesB IscA family
A21D_RS13940	COG0492	ferredoxin-NADP+ reductase activity
A21D_RS13945	COG1252	NADH dehydrogenase
A21D_RS13955	COG3584	3D domain protein
A21D_RS13975	COG0813	purine-nucleoside phosphorylase activity
A21D_RS13980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS13995	COG2032	superoxide dismutase activity
A21D_RS14000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A21D_RS14005	COG0166	Belongs to the GPI family
A21D_RS14010	COG2155	Conserved Protein
A21D_RS14015	COG1098	S1 RNA binding domain
A21D_RS14025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A21D_RS14040	COG1404	Belongs to the peptidase S8 family
A21D_RS14040	COG4412	M6 family metalloprotease domain protein
A21D_RS14045	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A21D_RS14050	COG3191	aminopeptidase activity
A21D_RS14060	COG2050	protein possibly involved in aromatic compounds catabolism
A21D_RS14065	COG1575	Belongs to the MenA family. Type 1 subfamily
A21D_RS14070	COG1169	isochorismate synthase
A21D_RS14075	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A21D_RS14080	COG0596	Alpha beta hydrolase
A21D_RS14085	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A21D_RS14090	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_RS14125	COG0494	nUDIX hydrolase
A21D_RS14130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A21D_RS14135	COG1116	anion transmembrane transporter activity
A21D_RS14140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A21D_RS14145	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A21D_RS14150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A21D_RS14155	COG0367	asparagine synthase
A21D_RS14160	COG4990	cell redox homeostasis
A21D_RS14170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A21D_RS14180	COG1454	alcohol dehydrogenase
A21D_RS14180	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS14185	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A21D_RS14190	COG0495	leucyl-tRNA aminoacylation
A21D_RS14200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_RS14230	COG2081	HI0933 family
A21D_RS14235	COG2244	polysaccharide biosynthetic process
A21D_RS14240	COG1187	pseudouridine synthase activity
A21D_RS14255	COG0510	thiamine kinase activity
A21D_RS14265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A21D_RS14270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_RS14280	COG1363	Peptidase, m42
A21D_RS14285	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A21D_RS14295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_RS14300	COG4848	Belongs to the UPF0354 family
A21D_RS14305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A21D_RS14310	COG1674	ftsk spoiiie
A21D_RS14320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A21D_RS14335	COG0849	cell division
A21D_RS14340	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A21D_RS14340	COG1605	Chorismate mutase
A21D_RS14350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A21D_RS14360	COG0123	including yeast histone deacetylase and acetoin utilization protein
A21D_RS14365	COG0517	IMP dehydrogenase activity
A21D_RS14370	COG0454	-acetyltransferase
A21D_RS14390	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A21D_RS14395	COG2203	Gaf domain
A21D_RS14395	COG2199	diguanylate cyclase activity
A21D_RS14400	COG1956	GAF domain-containing protein
A21D_RS14405	COG1309	transcriptional regulator
A21D_RS14410	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A21D_RS14415	COG1104	cysteine desulfurase activity
A21D_RS14420	COG0301	tRNA thio-modification
A21D_RS14430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A21D_RS14440	COG3874	Sporulation protein YtfJ
A21D_RS14445	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A21D_RS14450	COG0827	DNA restriction-modification system
A21D_RS14455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A21D_RS14465	COG0686	Belongs to the AlaDH PNT family
A21D_RS14470	COG0006	proline dipeptidase activity
A21D_RS14475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A21D_RS14480	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A21D_RS14490	COG4109	DRTGG domain
A21D_RS14500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A21D_RS14525	COG0587	DNA-directed DNA polymerase activity
A21D_RS14530	COG0281	malic enzyme
A21D_RS14535	COG1725	Transcriptional regulator
A21D_RS14545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A21D_RS14550	COG0825	malonyl-CoA metabolic process
A21D_RS14555	COG0205	6-phosphofructokinase activity
A21D_RS14565	COG3030	protein affecting phage T7 exclusion by the F plasmid
A21D_RS14570	COG0628	permease
A21D_RS14575	COG0372	Belongs to the citrate synthase family
A21D_RS14580	COG0538	isocitrate dehydrogenase activity
A21D_RS14585	COG0039	L-malate dehydrogenase activity
A21D_RS14595	COG0745	RESPONSE REGULATOR receiver
A21D_RS14600	COG5002	protein histidine kinase activity
A21D_RS14605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A21D_RS14605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A21D_RS14610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A21D_RS14615	COG0237	dephospho-CoA kinase activity
A21D_RS14620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A21D_RS14625	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A21D_RS14635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A21D_RS14640	COG3611	Membrane attachment protein
A21D_RS14645	COG1484	DNA-dependent DNA replication
A21D_RS14655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A21D_RS14660	COG2801	Transposase and inactivated derivatives
A21D_RS14670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A21D_RS14675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A21D_RS14680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A21D_RS14685	COG3326	Membrane
A21D_RS14690	COG0398	Pfam SNARE associated Golgi protein
A21D_RS14705	COG1363	Peptidase, m42
A21D_RS14710	COG0741	lytic transglycosylase activity
A21D_RS14715	COG1131	(ABC) transporter
A21D_RS14740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A21D_RS14745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A21D_RS14750	COG0072	phenylalanine-tRNA ligase activity
A21D_RS14750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A21D_RS14755	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A21D_RS14760	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A21D_RS14765	COG1286	toxin biosynthetic process
A21D_RS14770	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A21D_RS14770	COG1796	DNA polymerase
A21D_RS14775	COG1193	negative regulation of DNA recombination
A21D_RS14780	COG3766	membrane
A21D_RS14785	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_RS14790	COG1309	transcriptional regulator
A21D_RS14795	COG1024	Enoyl-CoA hydratase
A21D_RS14800	COG2086	electron transfer activity
A21D_RS14805	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A21D_RS14810	COG3118	belongs to the thioredoxin family
A21D_RS14815	COG0322	excinuclease ABC activity
A21D_RS14820	COG1719	4-vinyl reductase, 4VR
A21D_RS14825	COG2009	succinate dehydrogenase
A21D_RS14830	COG1053	succinate dehydrogenase
A21D_RS14835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A21D_RS14840	COG0824	Thioesterase
A21D_RS14845	COG2197	response regulator
A21D_RS14855	COG2226	methyltransferase
A21D_RS14865	COG0640	Transcriptional regulator
A21D_RS14890	COG1064	alcohol dehydrogenase
A21D_RS14895	COG1725	Transcriptional regulator
A21D_RS14900	COG1131	(ABC) transporter
A21D_RS14955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A21D_RS14960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A21D_RS14965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A21D_RS14980	COG0314	molybdopterin synthase activity
A21D_RS14985	COG0783	Belongs to the Dps family
A21D_RS15000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A21D_RS15005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A21D_RS15030	COG1846	Transcriptional regulator
A21D_RS15035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A21D_RS15040	COG5401	PFAM Sporulation and spore germination
A21D_RS15045	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A21D_RS15050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A21D_RS15055	COG0622	Phosphoesterase
A21D_RS15080	COG0544	peptidyl-prolyl cis-trans isomerase activity
A21D_RS15085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A21D_RS15095	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A21D_RS15105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A21D_RS15110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A21D_RS15115	COG0181	hydroxymethylbilane synthase activity
A21D_RS15120	COG1587	Uroporphyrinogen-III synthase
A21D_RS15125	COG0113	porphobilinogen synthase activity
A21D_RS15130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A21D_RS15135	COG1388	LysM domain
A21D_RS15150	COG0525	valine-tRNA ligase activity
A21D_RS15160	COG0189	ligase activity
A21D_RS15165	COG0285	dihydrofolate synthase activity
A21D_RS15175	COG2003	Belongs to the UPF0758 family
A21D_RS15180	COG1077	Cell shape determining protein MreB Mrl
A21D_RS15195	COG0850	regulation of cytokinetic process
A21D_RS15200	COG2894	cell division
A21D_RS15210	COG1994	Peptidase M50
A21D_RS15215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A21D_RS15220	COG2868	ribosomal protein
A21D_RS15225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A21D_RS15235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A21D_RS15240	COG0077	Prephenate dehydratase
A21D_RS15250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A21D_RS15260	COG0217	transcriptional regulatory protein
A21D_RS15265	COG0632	four-way junction helicase activity
A21D_RS15270	COG2255	four-way junction helicase activity
A21D_RS15280	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A21D_RS15285	COG0343	queuine tRNA-ribosyltransferase activity
A21D_RS15290	COG1862	Preprotein translocase
A21D_RS15305	COG2244	polysaccharide biosynthetic process
A21D_RS15315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A21D_RS15315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A21D_RS15320	COG5416	Lipopolysaccharide assembly protein A domain
A21D_RS15325	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A21D_RS15325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A21D_RS15330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A21D_RS15335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A21D_RS15340	COG1490	D-aminoacyl-tRNA deacylase activity
A21D_RS15345	COG3103	Sh3 type 3 domain protein
A21D_RS15345	COG4991	sh3 domain protein
A21D_RS15345	COG0860	N-Acetylmuramoyl-L-alanine amidase
A21D_RS15355	COG0124	histidyl-tRNA synthetase
A21D_RS15360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A21D_RS15375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A21D_RS15380	COG1959	2 iron, 2 sulfur cluster binding
A21D_RS15385	COG1104	cysteine desulfurase activity
A21D_RS15390	COG0482	sulfurtransferase activity
A21D_RS15400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A21D_RS15410	COG0628	permease
A21D_RS15420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A21D_RS15425	COG4472	Bacterial protein of unknown function (DUF965)
A21D_RS15430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A21D_RS15435	COG3906	Belongs to the UPF0473 family
A21D_RS15440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A21D_RS15445	COG4122	O-methyltransferase activity
A21D_RS15450	COG0572	uridine kinase
A21D_RS15455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A21D_RS15465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A21D_RS15490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A21D_RS15490	COG1263	PTS System
A21D_RS15500	COG1320	monovalent cation:proton antiporter activity
A21D_RS15505	COG2212	antiporter activity
A21D_RS15510	COG1863	multisubunit Na H antiporter MnhE subunit
A21D_RS15515	COG0651	ATP synthesis coupled electron transport
A21D_RS15520	COG1006	Multisubunit Na H antiporter MnhC subunit
A21D_RS15525	COG2111	Na H antiporter
A21D_RS15525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A21D_RS15535	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A21D_RS15540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A21D_RS15545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A21D_RS15550	COG1534	Rna-binding protein
A21D_RS15555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A21D_RS15560	COG1713	HD superfamily hydrolase involved in NAD metabolism
A21D_RS15565	COG0799	negative regulation of ribosome biogenesis
A21D_RS15575	COG1555	photosystem II stabilization
A21D_RS15575	COG1596	polysaccharide export
A21D_RS15580	COG2131	deaminase
A21D_RS15585	COG2333	competence protein COMEC
A21D_RS15585	COG0658	competence protein
A21D_RS15595	COG1466	dna polymerase III delta subunit
A21D_RS15600	COG0268	Binds directly to 16S ribosomal RNA
A21D_RS15605	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A21D_RS15610	COG0860	N-Acetylmuramoyl-L-alanine amidase
A21D_RS15620	COG0481	GTPase activity
A21D_RS15625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A21D_RS15630	COG1420	regulation of RNA biosynthetic process
A21D_RS15635	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A21D_RS15640	COG0443	Heat shock 70 kDa protein
A21D_RS15645	COG0484	heat shock protein binding
A21D_RS15650	COG2264	protein methyltransferase activity
A21D_RS15655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A21D_RS15660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A21D_RS15665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A21D_RS15670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A21D_RS15675	COG1610	YqeY-like protein
A21D_RS15680	COG1030	water channel activity
A21D_RS15685	COG4864	UPF0365 protein
A21D_RS15705	COG1702	phosphate starvation-inducible protein PhoH
A21D_RS15710	COG1480	7TM receptor with intracellular HD hydrolase
A21D_RS15715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A21D_RS15725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A21D_RS15735	COG1381	Involved in DNA repair and RecF pathway recombination
A21D_RS15740	COG0752	glycyl-tRNA synthetase alpha subunit
A21D_RS15745	COG0751	glycine-tRNA ligase activity
A21D_RS15750	COG0517	IMP dehydrogenase activity
A21D_RS15755	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A21D_RS15760	COG0358	DNA primase activity
A21D_RS15765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A21D_RS15775	COG2384	SAM-dependent methyltransferase
A21D_RS15780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A21D_RS15810	COG1030	water channel activity
A21D_RS15815	COG0704	Plays a role in the regulation of phosphate uptake
A21D_RS15850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A21D_RS15855	COG0477	Major facilitator Superfamily
A21D_RS15860	COG0768	penicillin binding
A21D_RS15865	COG0704	Plays a role in the regulation of phosphate uptake
A21D_RS15880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A21D_RS15885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A21D_RS15895	COG0705	Rhomboid family
A21D_RS15895	COG0457	Tetratricopeptide repeat
A21D_RS15910	COG0697	spore germination
A21D_RS15920	COG1940	carbohydrate kinase activity
A21D_RS15925	COG1368	sulfuric ester hydrolase activity
A21D_RS15940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_RS15980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A21D_RS15995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A21D_RS16000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A21D_RS16005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A21D_RS16010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A21D_RS16015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A21D_RS16020	COG1321	iron dependent repressor
A21D_RS16025	COG1752	Esterase of the alpha-beta hydrolase superfamily
A21D_RS16040	COG0006	proline dipeptidase activity
A21D_RS16045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A21D_RS16050	COG3854	ATPases associated with a variety of cellular activities
A21D_RS16090	COG0511	ligase activity, forming carbon-carbon bonds
A21D_RS16095	COG0439	Biotin carboxylase
A21D_RS16100	COG1302	Protein conserved in bacteria
A21D_RS16105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A21D_RS16110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A21D_RS16115	COG1570	exodeoxyribonuclease VII activity
A21D_RS16120	COG1722	exodeoxyribonuclease VII activity
A21D_RS16125	COG0142	geranyltranstransferase activity
A21D_RS16135	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A21D_RS16140	COG1438	arginine binding
A21D_RS16145	COG0497	DNA recombination
A21D_RS16150	COG0750	zinc metalloprotease
A21D_RS16160	COG0527	aspartate kinase activity
A21D_RS16170	COG3290	protein histidine kinase activity
A21D_RS16170	COG3829	transcription factor binding
A21D_RS16175	COG0280	phosphate acetyltransferase
A21D_RS16185	COG3426	butyrate kinase activity
A21D_RS16190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A21D_RS16195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A21D_RS16200	COG0022	dehydrogenase e1 component
A21D_RS16205	COG0508	dehydrogenase complex catalyzes the overall conversion of
A21D_RS16215	COG4129	membrane
A21D_RS16225	COG0346	lactoylglutathione lyase activity
A21D_RS16230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A21D_RS16240	COG2195	Cleaves the N-terminal amino acid of tripeptides
A21D_RS16245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A21D_RS16255	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS16260	COG1234	tRNA 3'-trailer cleavage
A21D_RS16265	COG0584	glycerophosphoryl diester phosphodiesterase
A21D_RS16270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_RS16275	COG0300	oxidoreductase activity
A21D_RS16285	COG0667	Aldo Keto reductase
A21D_RS16295	COG1379	DNA repair
A21D_RS16300	COG1300	Membrane
A21D_RS16305	COG0735	belongs to the Fur family
A21D_RS16315	COG4974	Belongs to the 'phage' integrase family
A21D_RS16320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A21D_RS16335	COG1686	Belongs to the peptidase S11 family
A21D_RS16345	COG2172	sigma factor antagonist activity
A21D_RS16365	COG0697	spore germination
A21D_RS16375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A21D_RS16385	COG0456	acetyltransferase
A21D_RS16395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A21D_RS16400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A21D_RS16405	COG1686	Belongs to the peptidase S11 family
A21D_RS16410	COG2715	membrane protein required for spore maturation
A21D_RS16415	COG0700	Nucleoside recognition
A21D_RS16420	COG1187	pseudouridine synthase activity
A21D_RS16425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_RS16430	COG1333	cytochrome c biogenesis protein
A21D_RS16435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A21D_RS16440	COG0745	RESPONSE REGULATOR receiver
A21D_RS16445	COG5002	protein histidine kinase activity
A21D_RS16470	COG0514	ATP-dependent DNA helicase (RecQ)
A21D_RS16485	COG4862	establishment of competence for transformation
A21D_RS16490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A21D_RS16495	COG0492	ferredoxin-NADP+ reductase activity
A21D_RS16505	COG2339	peptidase activity
A21D_RS16510	COG3773	Cell wall hydrolase
A21D_RS16510	COG3409	Peptidoglycan-binding domain 1 protein
A21D_RS16515	COG2959	enzyme of heme biosynthesis
A21D_RS16525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A21D_RS16535	COG0539	negative regulation of cytoplasmic translation
A21D_RS16550	COG1160	GTP binding
A21D_RS16555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A21D_RS16575	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A21D_RS16580	COG0776	regulation of translation
A21D_RS16590	COG0142	geranyltranstransferase activity
A21D_RS16595	COG2226	methyltransferase
A21D_RS16600	COG0142	geranyltranstransferase activity
A21D_RS16605	COG0105	UTP biosynthetic process
A21D_RS16610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A21D_RS16615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A21D_RS16620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A21D_RS16625	COG4401	Chorismate mutase type I
A21D_RS16630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A21D_RS16635	COG0287	Prephenate dehydrogenase
A21D_RS16640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A21D_RS16645	COG0457	Tetratricopeptide repeat
A21D_RS16650	COG5582	Belongs to the UPF0302 family
A21D_RS16665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A21D_RS16675	COG4347	Protein of unknown function (DUF1405)
A21D_RS16685	COG2738	Putative neutral zinc metallopeptidase
A21D_RS16695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A21D_RS16700	COG1694	Mazg nucleotide pyrophosphohydrolase
A21D_RS16705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A21D_RS16710	COG1803	Methylglyoxal synthase
A21D_RS16715	COG0438	transferase activity, transferring glycosyl groups
A21D_RS16720	COG0617	tRNA 3'-terminal CCA addition
A21D_RS16725	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A21D_RS16725	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A21D_RS16730	COG1199	ATP-dependent helicase activity
A21D_RS16730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A21D_RS16745	COG0436	Aminotransferase
A21D_RS16750	COG0017	Asparaginyl-tRNA synthetase
A21D_RS16755	COG3935	DnaD domain protein
A21D_RS16760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A21D_RS16765	COG4499	WXG100 protein secretion system (Wss), protein YukC
A21D_RS16765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A21D_RS16770	COG3331	DNA recombination
A21D_RS16795	COG3599	regulation of cell shape
A21D_RS16805	COG0116	Belongs to the methyltransferase superfamily
A21D_RS16810	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A21D_RS16815	COG3424	synthase
A21D_RS16820	COG1755	Isoprenylcysteine carboxyl methyltransferase
A21D_RS16825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A21D_RS16830	COG0659	secondary active sulfate transmembrane transporter activity
A21D_RS16845	COG1418	mRNA catabolic process
A21D_RS16855	COG0791	NLP P60 protein
A21D_RS16855	COG1388	LysM domain
A21D_RS16860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A21D_RS16865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A21D_RS16870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A21D_RS16875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A21D_RS16880	COG0805	protein transport
A21D_RS16885	COG4479	Belongs to the UPF0346 family
A21D_RS16890	COG1309	transcriptional regulator
A21D_RS16905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A21D_RS16905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A21D_RS16920	COG1254	Belongs to the acylphosphatase family
A21D_RS16925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A21D_RS16925	COG0723	plastoquinol--plastocyanin reductase activity
A21D_RS16940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_RS16950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A21D_RS16970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A21D_RS16985	COG0390	transport system, permease component
A21D_RS16990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A21D_RS16995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A21D_RS17000	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A21D_RS17005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A21D_RS17010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A21D_RS17015	COG1024	Enoyl-CoA hydratase
A21D_RS17020	COG0511	ligase activity, forming carbon-carbon bonds
A21D_RS17025	COG0439	Biotin carboxylase
A21D_RS17030	COG0318	PFAM AMP-dependent synthetase and ligase
A21D_RS17035	COG1960	acyl-CoA dehydrogenase activity
A21D_RS17040	COG1309	transcriptional regulator
A21D_RS17045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A21D_RS17050	COG0187	DNA topoisomerase II activity
A21D_RS17055	COG1832	CoA-binding protein
A21D_RS17070	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A21D_RS17075	COG1469	GTP cyclohydrolase I activity
A21D_RS17080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A21D_RS17095	COG0824	Thioesterase
A21D_RS17110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_RS17115	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A21D_RS17120	COG4191	Histidine kinase
A21D_RS17130	COG4846	Membrane protein involved in cytochrome C biogenesis
A21D_RS17135	COG2201	protein-glutamate methylesterase activity
A21D_RS17140	COG2111	Na H antiporter
A21D_RS17145	COG0785	Cytochrome C biogenesis protein
A21D_RS17150	COG3763	UPF0154 protein
A21D_RS17170	COG4224	UPF0291 protein
A21D_RS17180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A21D_RS17185	COG0789	Transcriptional regulator
A21D_RS17200	COG1404	Belongs to the peptidase S8 family
A21D_RS17400	COG5377	YqaJ viral recombinase family
A21D_RS17455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A21D_RS17465	COG3546	catalase activity
A21D_RS17495	COG0174	glutamine synthetase
A21D_RS17500	COG0789	Transcriptional regulator
A21D_RS17505	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A21D_RS17510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A21D_RS17515	COG0464	growth
A21D_RS17520	COG1923	regulation of RNA biosynthetic process
A21D_RS17525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A21D_RS17530	COG0783	Belongs to the Dps family
A21D_RS17535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A21D_RS17540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A21D_RS17550	COG4550	Control of competence regulator ComK, YlbF/YmcA
A21D_RS17555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A21D_RS17560	COG2359	stage V sporulation protein S
A21D_RS17565	COG1692	metallophosphoesterase
A21D_RS17570	COG1418	mRNA catabolic process
A21D_RS17575	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A21D_RS17580	COG1546	Belongs to the CinA family
A21D_RS17580	COG1058	Belongs to the CinA family
A21D_RS17585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A21D_RS17590	COG1426	Protein conserved in bacteria
A21D_RS17605	COG0300	oxidoreductase activity
A21D_RS17610	COG0612	Peptidase, M16
A21D_RS17615	COG0612	Peptidase, M16
A21D_RS17620	COG1079	Belongs to the binding-protein-dependent transport system permease family
A21D_RS17625	COG4603	Belongs to the binding-protein-dependent transport system permease family
A21D_RS17630	COG3845	ABC transporter
A21D_RS17635	COG1744	ABC transporter substrate-binding protein PnrA-like
A21D_RS17640	COG2188	Transcriptional regulator
A21D_RS17645	COG1674	ftsk spoiiie
A21D_RS17655	COG0740	serine-type endopeptidase activity
A21D_RS17660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A21D_RS17665	COG0527	aspartate kinase activity
A21D_RS17670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A21D_RS17675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A21D_RS17680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A21D_RS17685	COG1873	PFAM PRC-barrel domain
A21D_RS17690	COG0612	Peptidase, M16
A21D_RS17695	COG0726	polysaccharide deacetylase
A21D_RS17700	COG1185	polyribonucleotide nucleotidyltransferase activity
A21D_RS17705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A21D_RS17710	COG0196	riboflavin kinase activity
A21D_RS17715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A21D_RS17720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A21D_RS17725	COG1550	Protein conserved in bacteria
A21D_RS17730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A21D_RS17740	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A21D_RS17745	COG0195	Participates in both transcription termination and antitermination
A21D_RS17750	COG0779	Required for maturation of 30S ribosomal subunits
A21D_RS17755	COG2176	DNA-directed DNA polymerase activity
A21D_RS17760	COG0750	zinc metalloprotease
A21D_RS17765	COG4589	Belongs to the CDS family
A21D_RS17770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A21D_RS17775	COG0233	cytoplasmic translational termination
A21D_RS17780	COG0528	UMP kinase activity
A21D_RS17785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A21D_RS17790	COG0052	Belongs to the universal ribosomal protein uS2 family
A21D_RS17810	COG1191	sigma factor activity
A21D_RS17815	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A21D_RS17820	COG1776	CheC inhibitor of MCP methylation
A21D_RS17825	COG0835	chemotaxis
A21D_RS17830	COG0643	Histidine kinase
A21D_RS17830	COG2198	Histidine kinase
A21D_RS17835	COG2201	protein-glutamate methylesterase activity
A21D_RS17840	COG0455	bacterial-type flagellum organization
A21D_RS17845	COG1419	protein localization to endoplasmic reticulum
A21D_RS17850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A21D_RS17855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A21D_RS17860	COG1684	flagellar biosynthetic protein fliR
A21D_RS17865	COG1987	bacterial-type flagellum assembly
A21D_RS17870	COG1338	Plays a role in the flagellum-specific transport system
A21D_RS17875	COG3190	flagellar
A21D_RS17880	COG2201	protein-glutamate methylesterase activity
A21D_RS17885	COG1776	CheC inhibitor of MCP methylation
A21D_RS17885	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A21D_RS17890	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A21D_RS17895	COG1580	Controls the rotational direction of flagella during chemotaxis
A21D_RS17900	COG1582	Flagellar protein (FlbD)
A21D_RS17905	COG4786	Flagellar basal body rod
A21D_RS17910	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A21D_RS17915	COG3144	bacterial-type flagellum assembly
A21D_RS17930	COG1157	protein secretion by the type III secretion system
A21D_RS17940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A21D_RS17945	COG1766	The M ring may be actively involved in energy transduction
A21D_RS17950	COG1677	Flagellar hook-basal body complex protein FliE
A21D_RS17955	COG1558	bacterial-type flagellum-dependent cell motility
A21D_RS17960	COG1815	bacterial-type flagellum-dependent cell motility
A21D_RS17970	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A21D_RS17975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A21D_RS17980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A21D_RS17985	COG4974	Belongs to the 'phage' integrase family
A21D_RS17990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A21D_RS17995	COG0758	DNA mediated transformation
A21D_RS18000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A21D_RS18005	COG0045	succinate-CoA ligase (ADP-forming) activity
A21D_RS18010	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A21D_RS18020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A21D_RS18025	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A21D_RS18035	COG0335	large ribosomal subunit rRNA binding
A21D_RS18040	COG0336	Belongs to the RNA methyltransferase TrmD family
A21D_RS18045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A21D_RS18055	COG1837	Belongs to the UPF0109 family
A21D_RS18060	COG0228	four-way junction DNA binding
A21D_RS18065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A21D_RS18070	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A21D_RS18080	COG0552	protein localization to endoplasmic reticulum
A21D_RS18085	COG1196	nuclear chromosome segregation
A21D_RS18090	COG4840	Belongs to the UPF0435 family
A21D_RS18095	COG0571	ribonuclease III activity
A21D_RS18100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A21D_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
A21D_RS18110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A21D_RS18115	COG0416	fatty acid biosynthetic process
A21D_RS18120	COG1349	DNA-binding transcription factor activity
A21D_RS18125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A21D_RS18130	COG1760	l-serine dehydratase
A21D_RS18135	COG1760	l-serine dehydratase
A21D_RS18145	COG1461	Dihydroxyacetone kinase
A21D_RS18150	COG1302	Protein conserved in bacteria
A21D_RS18155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A21D_RS18165	COG1564	THIamine pyrophosphokinase
A21D_RS18170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A21D_RS18175	COG1162	GTPase activity
A21D_RS18180	COG0515	serine threonine protein kinase
A21D_RS18180	COG2815	serine threonine protein kinase
A21D_RS18185	COG0631	protein serine/threonine phosphatase activity
A21D_RS18190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A21D_RS18190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A21D_RS18195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A21D_RS18200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A21D_RS18205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A21D_RS18210	COG1758	RNA polymerase activity
A21D_RS18215	COG0194	GDP metabolic process
A21D_RS18220	COG2052	Domain of unknown function (DUF370)
A21D_RS18225	COG1561	YicC-like family, N-terminal region
A21D_RS18230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A21D_RS18245	COG1764	response to oxidative stress
A21D_RS18250	COG0583	DNA-binding transcription factor activity
A21D_RS18255	COG2226	methyltransferase
A21D_RS18260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A21D_RS18265	COG0284	orotidine-5'-phosphate decarboxylase activity
A21D_RS18270	COG0167	dihydroorotate dehydrogenase activity
A21D_RS18275	COG0543	2 iron, 2 sulfur cluster binding
A21D_RS18285	COG0505	Belongs to the CarA family
A21D_RS18290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A21D_RS18295	COG0540	Belongs to the ATCase OTCase family
A21D_RS18300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A21D_RS18305	COG0564	pseudouridine synthase activity
A21D_RS18310	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A21D_RS18315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A21D_RS18320	COG3599	regulation of cell shape
A21D_RS18325	COG2302	S4 RNA-binding domain
A21D_RS18330	COG0762	integral membrane protein
A21D_RS18335	COG1799	cell septum assembly
A21D_RS18340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A21D_RS18345	COG1496	oxidoreductase activity
A21D_RS18350	COG1873	PFAM PRC-barrel domain
A21D_RS18355	COG1191	sigma factor activity
A21D_RS18360	COG1191	sigma factor activity
A21D_RS18370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A21D_RS18375	COG0849	cell division
A21D_RS18380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A21D_RS18385	COG0772	Belongs to the SEDS family
A21D_RS18390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A21D_RS18395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A21D_RS18400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A21D_RS18405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A21D_RS18410	COG0768	penicillin binding
A21D_RS18415	COG0768	penicillin binding
A21D_RS18420	COG4839	cell division protein FtsL
A21D_RS18425	COG0275	rRNA processing
A21D_RS18430	COG2001	Belongs to the MraZ family
A21D_RS18435	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A21D_RS18445	COG0454	-acetyltransferase
A21D_RS18455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A21D_RS18460	COG1399	metal-binding, possibly nucleic acid-binding protein
A21D_RS18465	COG1323	Belongs to the UPF0348 family
A21D_RS18470	COG3480	Lon protease (S16) C-terminal proteolytic domain
A21D_RS18475	COG3314	Sporulation integral membrane protein YlbJ
A21D_RS18480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A21D_RS18485	COG0742	ribosomal rna small subunit methyltransferase
A21D_RS18490	COG4471	UPF0298 protein
A21D_RS18495	COG3679	Belongs to the UPF0342 family
A21D_RS18510	COG2340	Cysteine-rich secretory protein family
A21D_RS18525	COG2322	membrane
A21D_RS18530	COG3336	cytochrome c oxidase
A21D_RS18540	COG1845	cytochrome c oxidase, subunit III
A21D_RS18550	COG2010	Cytochrome c
A21D_RS18550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A21D_RS18555	COG0109	protoheme IX farnesyltransferase activity
A21D_RS18560	COG1612	heme a metabolic process
A21D_RS18565	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A21D_RS18570	COG0772	Belongs to the SEDS family
A21D_RS18575	COG4838	Belongs to the UPF0358 family
A21D_RS18580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A21D_RS18605	COG0483	inositol monophosphate 1-phosphatase activity
A21D_RS18620	COG4493	Belongs to the UPF0637 family
A21D_RS18625	COG4476	Belongs to the UPF0223 family
A21D_RS18635	COG0726	polysaccharide deacetylase
A21D_RS18640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A21D_RS18660	COG0022	dehydrogenase e1 component
A21D_RS18675	COG0242	peptide deformylase activity
A21D_RS18680	COG0561	phosphatase activity
A21D_RS18685	COG5503	Protein of unknown function (DUF1447)
A21D_RS18690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A21D_RS18695	COG0569	domain protein
A21D_RS18700	COG1132	(ABC) transporter
A21D_RS18705	COG1132	(ABC) transporter
A21D_RS18710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A21D_RS18720	COG1473	amidohydrolase
A21D_RS18725	COG2171	N-acyltransferase activity
A21D_RS18730	COG0517	IMP dehydrogenase activity
A21D_RS18735	COG0640	Transcriptional regulator
A21D_RS18745	COG1408	metallophosphoesterase
A21D_RS18775	COG0436	Aminotransferase
A21D_RS18795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A21D_RS18805	COG5001	Diguanylate cyclase
A21D_RS18805	COG3300	MHYT domain
A21D_RS18810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A21D_RS18820	COG0778	Nitroreductase
A21D_RS18845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A21D_RS18860	COG2323	membrane
A21D_RS18865	COG1301	dicarboxylic acid transport
A21D_RS18870	COG0604	alcohol dehydrogenase
A21D_RS18875	COG0003	Pfam Anion-transporting ATPase
A21D_RS18885	COG1966	Carbon starvation protein
A21D_RS18890	COG3069	C4-dicarboxylate transmembrane transporter activity
A21D_RS18915	COG2720	vancomycin resistance protein
A21D_RS18920	COG1252	NADH dehydrogenase
A21D_RS18940	COG2027	D-alanyl-D-alanine carboxypeptidase
A21D_RS18945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A21D_RS18950	COG0667	Aldo Keto reductase
A21D_RS18955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A21D_RS18960	COG0419	ATPase involved in DNA repair
A21D_RS18965	COG0420	3'-5' exonuclease activity
A21D_RS18970	COG2226	methyltransferase
A21D_RS18975	COG5504	Zn-dependent protease
A21D_RS18980	COG2814	Major facilitator Superfamily
A21D_RS18985	COG1301	dicarboxylic acid transport
A21D_RS18995	COG0446	pyridine nucleotide-disulphide oxidoreductase
A21D_RS19005	COG1063	alcohol dehydrogenase
A21D_RS19115	COG0584	glycerophosphoryl diester phosphodiesterase
A21D_RS19120	COG0584	glycerophosphoryl diester phosphodiesterase
A21D_RS19135	COG1175	transmembrane transport
A21D_RS19140	COG3842	ATPase activity
A21D_RS19150	COG1585	Membrane protein implicated in regulation of membrane protease activity
A21D_RS19155	COG2268	Band 7 protein
A21D_RS19180	COG1349	DNA-binding transcription factor activity
A21D_RS19190	COG2391	methyltransferase activity
A21D_RS19205	COG0512	Glutamine amidotransferase of anthranilate synthase
A21D_RS19225	COG1533	DNA photolyase activity
A21D_RS19235	COG5564	TIM-barrel signal transduction protein
A21D_RS19245	COG5564	TIM-barrel signal transduction protein
A21D_RS19255	COG1408	metallophosphoesterase
A21D_RS19285	COG1228	amidohydrolase
A21D_RS19315	COG1131	(ABC) transporter
A21D_RS19330	COG3425	synthase
A21D_RS19335	COG2202	Pas domain
A21D_RS19335	COG1366	Belongs to the anti-sigma-factor antagonist family
A21D_RS19340	COG2329	Antibiotic biosynthesis monooxygenase
A21D_RS19360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A21D_RS19375	COG0179	Fumarylacetoacetate (FAA) hydrolase
A21D_RS19380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A21D_RS19390	COG1012	belongs to the aldehyde dehydrogenase family
A21D_RS19405	COG0583	DNA-binding transcription factor activity
A21D_RS19410	COG0477	Major facilitator Superfamily
A21D_RS19415	COG0204	Acyl-transferase
A21D_RS19440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A21D_RS19445	COG0431	NADPH-dependent FMN reductase
A21D_RS19450	COG1368	sulfuric ester hydrolase activity
A21D_RS19455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A21D_RS19485	COG1295	ribonuclease BN
A21D_RS19490	COG0501	Belongs to the peptidase M48B family
A21D_RS19500	COG5002	protein histidine kinase activity
A21D_RS19500	COG3850	Histidine kinase
A21D_RS19505	COG0745	RESPONSE REGULATOR receiver
A21D_RS19515	COG1063	alcohol dehydrogenase
A21D_RS19530	COG0508	dehydrogenase complex catalyzes the overall conversion of
A21D_RS19535	COG0022	dehydrogenase e1 component
A21D_RS19540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A21D_RS19545	COG3284	Transcriptional regulator
A21D_RS19565	COG2184	nucleotidyltransferase activity
A21D_RS19605	COG1388	LysM domain
A21D_RS19605	COG3409	Peptidoglycan-binding domain 1 protein
A21D_RS19605	COG5632	N-Acetylmuramoyl-L-alanine amidase
A21D_RS19610	COG4824	toxin secretion phage lysis holin