locus-tag	class	description
LWC06_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LWC06_RS00010	COG0592	DNA-directed DNA polymerase activity
LWC06_RS00015	COG2501	S4 domain
LWC06_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LWC06_RS00030	COG0187	DNA topoisomerase II activity
LWC06_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LWC06_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LWC06_RS00050	COG0516	GMP reductase activity
LWC06_RS00050	COG0517	IMP dehydrogenase activity
LWC06_RS00060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LWC06_RS00065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LWC06_RS00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LWC06_RS00075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LWC06_RS00080	COG2011	ABC-type metal ion transport system permease component
LWC06_RS00085	COG1464	Belongs to the NlpA lipoprotein family
LWC06_RS00105	COG2357	RelA SpoT domain protein
LWC06_RS00115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LWC06_RS00120	COG1428	Deoxynucleoside kinase
LWC06_RS00125	COG1428	Deoxynucleoside kinase
LWC06_RS00135	COG1301	dicarboxylic acid transport
LWC06_RS00140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWC06_RS00145	COG3425	synthase
LWC06_RS00150	COG1017	nitric oxide dioxygenase activity
LWC06_RS00150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LWC06_RS00155	COG1959	2 iron, 2 sulfur cluster binding
LWC06_RS00160	COG0693	protein deglycase activity
LWC06_RS00165	COG1388	LysM domain
LWC06_RS00165	COG3858	chitin binding
LWC06_RS00170	COG1335	isochorismatase
LWC06_RS00175	COG0590	tRNA wobble adenosine to inosine editing
LWC06_RS00190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LWC06_RS00195	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LWC06_RS00200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LWC06_RS00220	COG1982	Orn Lys Arg decarboxylase major
LWC06_RS00225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LWC06_RS00230	COG3870	Protein conserved in bacteria
LWC06_RS00235	COG1728	Protein conserved in bacteria
LWC06_RS00240	COG0470	DNA polymerase III
LWC06_RS00245	COG1774	PSP1 C-terminal conserved region
LWC06_RS00250	COG4467	Involved in initiation control of chromosome replication
LWC06_RS00255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LWC06_RS00260	COG2827	Endonuclease containing a URI domain
LWC06_RS00265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LWC06_RS00270	COG2002	toxin-antitoxin pair type II binding
LWC06_RS00280	COG0084	hydrolase, TatD family'
LWC06_RS00285	COG3583	domain protein
LWC06_RS00285	COG3584	3D domain protein
LWC06_RS00290	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LWC06_RS00295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LWC06_RS00305	COG4466	Protein conserved in bacteria
LWC06_RS00315	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LWC06_RS00320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LWC06_RS00325	COG2088	sporulation resulting in formation of a cellular spore
LWC06_RS00330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LWC06_RS00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LWC06_RS00340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LWC06_RS00345	COG0193	aminoacyl-tRNA hydrolase activity
LWC06_RS00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LWC06_RS00360	COG2002	toxin-antitoxin pair type II binding
LWC06_RS00365	COG2244	polysaccharide biosynthetic process
LWC06_RS00370	COG3956	TIGRFAM MazG family protein
LWC06_RS00375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LWC06_RS00400	COG1098	S1 RNA binding domain
LWC06_RS00410	COG2208	phosphoserine phosphatase activity
LWC06_RS00415	COG2304	oxidoreductase activity
LWC06_RS00420	COG0515	serine threonine protein kinase
LWC06_RS00425	COG0037	tRNA processing
LWC06_RS00430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LWC06_RS00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LWC06_RS00440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LWC06_RS00445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LWC06_RS00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LWC06_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LWC06_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LWC06_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LWC06_RS00475	COG1396	sequence-specific DNA binding
LWC06_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LWC06_RS00560	COG1285	pathogenesis
LWC06_RS00570	COG3880	PFAM UvrB UvrC protein
LWC06_RS00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
LWC06_RS00580	COG0542	response to heat
LWC06_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LWC06_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
LWC06_RS00595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LWC06_RS00600	COG1045	serine acetyltransferase
LWC06_RS00605	COG0215	cysteine-tRNA ligase activity
LWC06_RS00615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LWC06_RS00620	COG3688	RNA-binding protein containing a PIN domain
LWC06_RS00630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LWC06_RS00635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LWC06_RS00640	COG0250	Participates in transcription elongation, termination and antitermination
LWC06_RS00645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LWC06_RS00650	COG0081	regulation of translation
LWC06_RS00655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LWC06_RS00660	COG0222	ribosome binding
LWC06_RS00665	COG2813	Specifically methylates the guanine in position
LWC06_RS00670	COG0085	RNA polymerase activity
LWC06_RS00675	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LWC06_RS00680	COG1358	cellular component organization or biogenesis
LWC06_RS00685	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LWC06_RS00690	COG0049	tRNA binding
LWC06_RS00695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LWC06_RS00700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LWC06_RS00705	COG0051	transcription antitermination factor activity, RNA binding
LWC06_RS00710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LWC06_RS00715	COG0088	Forms part of the polypeptide exit tunnel
LWC06_RS00720	COG0089	rRNA binding
LWC06_RS00725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LWC06_RS00730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LWC06_RS00735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LWC06_RS00740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LWC06_RS00745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LWC06_RS00750	COG0255	Belongs to the universal ribosomal protein uL29 family
LWC06_RS00755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LWC06_RS00760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LWC06_RS00765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LWC06_RS00770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LWC06_RS00775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LWC06_RS00780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LWC06_RS00785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LWC06_RS00790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LWC06_RS00795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LWC06_RS00800	COG1841	ribosomal large subunit assembly
LWC06_RS00805	COG0200	Binds to the 23S rRNA
LWC06_RS00810	COG0201	protein transport
LWC06_RS00815	COG0563	adenylate kinase activity
LWC06_RS00820	COG2163	COG2163 Ribosomal protein L14E L6E L27E
LWC06_RS00825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LWC06_RS00830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LWC06_RS00835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LWC06_RS00840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LWC06_RS00845	COG0202	RNA polymerase activity
LWC06_RS00850	COG0203	ribosomal protein L17
LWC06_RS00855	COG1122	ATPase activity
LWC06_RS00860	COG1122	ATPase activity
LWC06_RS00865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LWC06_RS00870	COG0101	tRNA pseudouridine synthase activity
LWC06_RS00875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LWC06_RS00880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LWC06_RS00900	COG0714	Associated with various cellular activities
LWC06_RS00905	COG4548	von Willebrand factor, type A
LWC06_RS00925	COG1295	ribonuclease BN
LWC06_RS00950	COG0860	N-Acetylmuramoyl-L-alanine amidase
LWC06_RS00955	COG0489	protein tyrosine kinase activity
LWC06_RS00965	COG2194	sulfuric ester hydrolase activity
LWC06_RS00970	COG0726	polysaccharide deacetylase
LWC06_RS01015	COG0494	nUDIX hydrolase
LWC06_RS01030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LWC06_RS01035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LWC06_RS01110	COG1595	DNA-templated transcription, initiation
LWC06_RS01115	COG5662	AntiSigma factor
LWC06_RS01120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LWC06_RS01125	COG4856	YbbR-like protein
LWC06_RS01130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LWC06_RS01135	COG0745	RESPONSE REGULATOR receiver
LWC06_RS01140	COG5002	protein histidine kinase activity
LWC06_RS01140	COG3850	Histidine kinase
LWC06_RS01145	COG0577	efflux transmembrane transporter activity
LWC06_RS01170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LWC06_RS01195	COG1404	Belongs to the peptidase S8 family
LWC06_RS01200	COG3665	Urea carboxylase-associated protein
LWC06_RS01205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWC06_RS01220	COG2217	Heavy metal translocating P-type atpase
LWC06_RS01230	COG3344	reverse transcriptase
LWC06_RS01245	COG1801	Protein of unknown function DUF72
LWC06_RS01250	COG0488	(ABC) transporter
LWC06_RS01270	COG3706	GGDEF domain
LWC06_RS01280	COG1271	oxidase subunit
LWC06_RS01285	COG1294	oxidase, subunit
LWC06_RS01290	COG4988	ABC transporter
LWC06_RS01295	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LWC06_RS01305	COG1309	transcriptional regulator
LWC06_RS01310	COG1131	(ABC) transporter
LWC06_RS01330	COG0243	molybdopterin cofactor binding
LWC06_RS01360	COG2223	nitrite transmembrane transporter activity
LWC06_RS01370	COG2197	response regulator
LWC06_RS01380	COG4585	Histidine kinase
LWC06_RS01480	COG1114	Component of the transport system for branched-chain amino acids
LWC06_RS01485	COG1802	Transcriptional regulator
LWC06_RS01490	COG0753	catalase activity
LWC06_RS01495	COG0668	transmembrane transport
LWC06_RS01510	COG1413	lyase activity
LWC06_RS01515	COG1607	acyl-coa hydrolase
LWC06_RS01525	COG2124	cytochrome p450
LWC06_RS01530	COG1725	Transcriptional regulator
LWC06_RS01535	COG1131	(ABC) transporter
LWC06_RS01550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LWC06_RS01555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LWC06_RS01560	COG0083	homoserine kinase activity
LWC06_RS01565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LWC06_RS01570	COG0460	homoserine dehydrogenase
LWC06_RS01590	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LWC06_RS01595	COG2814	Major facilitator Superfamily
LWC06_RS01610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LWC06_RS01640	COG2855	membrane
LWC06_RS01650	COG0789	Transcriptional regulator
LWC06_RS01655	COG0352	thiamine-phosphate diphosphorylase activity
LWC06_RS01660	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LWC06_RS01675	COG1063	alcohol dehydrogenase
LWC06_RS01695	COG4145	pantothenate transmembrane transporter activity
LWC06_RS01705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWC06_RS01715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LWC06_RS01720	COG5506	Protein of unknown function (DUF1694)
LWC06_RS01735	COG5577	PFAM Coat F domain
LWC06_RS01750	COG0708	Exodeoxyribonuclease III
LWC06_RS01755	COG1725	Transcriptional regulator
LWC06_RS01760	COG1131	(ABC) transporter
LWC06_RS01775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWC06_RS01790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LWC06_RS01795	COG0095	Lipoate-protein ligase
LWC06_RS01805	COG0159	tryptophan synthase activity
LWC06_RS01810	COG0133	tryptophan synthase activity
LWC06_RS01815	COG0135	phosphoribosylanthranilate isomerase activity
LWC06_RS01820	COG0134	indole-3-glycerol-phosphate synthase activity
LWC06_RS01825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LWC06_RS01830	COG0512	Glutamine amidotransferase of anthranilate synthase
LWC06_RS01830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LWC06_RS01835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LWC06_RS01850	COG1181	Belongs to the D-alanine--D-alanine ligase family
LWC06_RS01855	COG1115	amino acid carrier protein
LWC06_RS01860	COG0778	Nitroreductase
LWC06_RS01880	COG1418	mRNA catabolic process
LWC06_RS01885	COG1876	peptidase activity
LWC06_RS01890	COG2814	Major facilitator Superfamily
LWC06_RS01895	COG4166	transmembrane transport
LWC06_RS01900	COG1970	mechanosensitive ion channel activity
LWC06_RS01920	COG0519	Catalyzes the synthesis of GMP from XMP
LWC06_RS01925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LWC06_RS01930	COG1268	BioY protein
LWC06_RS01935	COG0840	transmembrane signaling receptor activity
LWC06_RS01950	COG0656	L-ascorbic acid biosynthetic process
LWC06_RS01965	COG1304	FMN binding
LWC06_RS01970	COG4876	unkown
LWC06_RS01975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWC06_RS01980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LWC06_RS01985	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWC06_RS01990	COG4605	iron ion homeostasis
LWC06_RS01995	COG4604	ABC transporter, ATP-binding protein
LWC06_RS02000	COG4607	ABC-type enterochelin transport system periplasmic component
LWC06_RS02005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LWC06_RS02010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LWC06_RS02015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LWC06_RS02015	COG0140	phosphoribosyl-ATP diphosphatase activity
LWC06_RS02020	COG0107	imidazoleglycerol-phosphate synthase activity
LWC06_RS02025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LWC06_RS02030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LWC06_RS02035	COG0131	Imidazoleglycerol-phosphate dehydratase
LWC06_RS02040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LWC06_RS02045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LWC06_RS02050	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LWC06_RS02055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LWC06_RS02060	COG2832	Protein of unknown function (DUF454)
LWC06_RS02070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LWC06_RS02075	COG1126	abc transporter atp-binding protein
LWC06_RS02080	COG0765	amino acid transport
LWC06_RS02085	COG0765	amino acid transport
LWC06_RS02095	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LWC06_RS02105	COG0673	inositol 2-dehydrogenase activity
LWC06_RS02115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LWC06_RS02120	COG2839	Protein conserved in bacteria
LWC06_RS02125	COG0351	phosphomethylpyrimidine kinase
LWC06_RS02130	COG1335	isochorismatase
LWC06_RS02140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LWC06_RS02150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWC06_RS02155	COG0765	amino acid transport
LWC06_RS02160	COG1126	abc transporter atp-binding protein
LWC06_RS02165	COG0714	Associated with various cellular activities
LWC06_RS02170	COG0386	Belongs to the glutathione peroxidase family
LWC06_RS02175	COG3949	Membrane
LWC06_RS02180	COG2508	Transcriptional regulator
LWC06_RS02180	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LWC06_RS02185	COG0686	Belongs to the AlaDH PNT family
LWC06_RS02190	COG1054	Belongs to the UPF0176 family
LWC06_RS02205	COG1278	Cold shock
LWC06_RS02210	COG2226	methyltransferase
LWC06_RS02210	COG1073	alpha beta
LWC06_RS02220	COG2084	Dehydrogenase
LWC06_RS02230	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LWC06_RS02235	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
LWC06_RS02240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWC06_RS02245	COG0745	RESPONSE REGULATOR receiver
LWC06_RS02250	COG5002	protein histidine kinase activity
LWC06_RS02250	COG3850	Histidine kinase
LWC06_RS02255	COG1217	gtp-binding protein TYPA
LWC06_RS02260	COG1263	PTS System
LWC06_RS02260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LWC06_RS02265	COG0366	Alpha amylase catalytic
LWC06_RS02270	COG2188	Transcriptional regulator
LWC06_RS02275	COG1834	amidinotransferase
LWC06_RS02280	COG3403	YqcI/YcgG family
LWC06_RS02285	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LWC06_RS02290	COG1131	(ABC) transporter
LWC06_RS02300	COG0183	Belongs to the thiolase family
LWC06_RS02320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWC06_RS02330	COG0745	RESPONSE REGULATOR receiver
LWC06_RS02335	COG5002	protein histidine kinase activity
LWC06_RS02335	COG3850	Histidine kinase
LWC06_RS02345	COG1597	lipid kinase activity
LWC06_RS02350	COG1846	Transcriptional regulator
LWC06_RS02355	COG0702	epimerase
LWC06_RS02375	COG1307	EDD domain protein, DegV family
LWC06_RS02380	COG0697	spore germination
LWC06_RS02385	COG0513	Belongs to the DEAD box helicase family
LWC06_RS02390	COG0705	Rhomboid family
LWC06_RS02395	COG0736	holo-[acyl-carrier-protein] synthase activity
LWC06_RS02400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LWC06_RS02400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LWC06_RS02405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LWC06_RS02410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LWC06_RS02420	COG2337	Toxic component of a toxin-antitoxin (TA) module
LWC06_RS02425	COG1366	Belongs to the anti-sigma-factor antagonist family
LWC06_RS02430	COG1366	Belongs to the anti-sigma-factor antagonist family
LWC06_RS02435	COG2172	sigma factor antagonist activity
LWC06_RS02440	COG2208	phosphoserine phosphatase activity
LWC06_RS02445	COG1366	Belongs to the anti-sigma-factor antagonist family
LWC06_RS02450	COG2172	sigma factor antagonist activity
LWC06_RS02455	COG1191	sigma factor activity
LWC06_RS02460	COG2208	phosphoserine phosphatase activity
LWC06_RS02465	COG2183	response to ionizing radiation
LWC06_RS02470	COG0753	catalase activity
LWC06_RS02475	COG3091	SprT-like family
LWC06_RS02565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LWC06_RS02570	COG0802	atpase or kinase
LWC06_RS02575	COG1214	PFAM Peptidase M22, glycoprotease
LWC06_RS02580	COG0456	acetyltransferase
LWC06_RS02585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LWC06_RS02590	COG0772	Belongs to the SEDS family
LWC06_RS02595	COG0488	(ABC) transporter
LWC06_RS02605	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LWC06_RS02615	COG1266	CAAX protease self-immunity
LWC06_RS02620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LWC06_RS02625	COG0459	protein refolding
LWC06_RS02630	COG0582	viral genome integration into host DNA
LWC06_RS02645	COG0210	DNA helicase
LWC06_RS02665	COG0590	tRNA wobble adenosine to inosine editing
LWC06_RS02670	COG4873	Protein conserved in bacteria
LWC06_RS02680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LWC06_RS02685	COG4978	Transcriptional regulator
LWC06_RS02685	COG0789	Transcriptional regulator
LWC06_RS02690	COG0456	acetyltransferase
LWC06_RS02695	COG1309	transcriptional regulator
LWC06_RS02700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LWC06_RS02705	COG0390	transport system, permease component
LWC06_RS02710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LWC06_RS02720	COG0745	RESPONSE REGULATOR receiver
LWC06_RS02725	COG2205	protein histidine kinase activity
LWC06_RS02730	COG1136	(ABC) transporter
LWC06_RS02735	COG0577	efflux transmembrane transporter activity
LWC06_RS02745	COG1309	transcriptional regulator
LWC06_RS02755	COG0668	transmembrane transport
LWC06_RS02760	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
LWC06_RS02765	COG0697	spore germination
LWC06_RS02770	COG0531	amino acid
LWC06_RS02785	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LWC06_RS02810	COG0714	Associated with various cellular activities
LWC06_RS02815	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
LWC06_RS02820	COG1305	Transglutaminase-like
LWC06_RS02825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LWC06_RS02825	COG0519	Catalyzes the synthesis of GMP from XMP
LWC06_RS02830	COG2252	PERMEase
LWC06_RS02840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LWC06_RS02845	COG2258	MOSC domain
LWC06_RS02855	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
LWC06_RS02860	COG0519	Catalyzes the synthesis of GMP from XMP
LWC06_RS02865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LWC06_RS02870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LWC06_RS02875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LWC06_RS02880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LWC06_RS02885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LWC06_RS02890	COG0047	phosphoribosylformylglycinamidine synthase activity
LWC06_RS02895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LWC06_RS02900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LWC06_RS02905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LWC06_RS02910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LWC06_RS02915	COG0138	bifunctional purine biosynthesis protein purh
LWC06_RS02920	COG0151	Belongs to the GarS family
LWC06_RS02925	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LWC06_RS02930	COG1470	cell adhesion involved in biofilm formation
LWC06_RS02935	COG4496	protein, YerC YecD
LWC06_RS02940	COG0084	hydrolase, TatD family'
LWC06_RS02945	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LWC06_RS02950	COG0210	DNA helicase
LWC06_RS02955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LWC06_RS02960	COG4851	CamS sex pheromone cAM373 precursor
LWC06_RS02965	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS02985	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LWC06_RS02990	COG0154	amidase activity
LWC06_RS02995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LWC06_RS03000	COG1597	lipid kinase activity
LWC06_RS03005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LWC06_RS03010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LWC06_RS03040	COG0640	Transcriptional regulator
LWC06_RS03090	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LWC06_RS03120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LWC06_RS03125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LWC06_RS03135	COG0109	protoheme IX farnesyltransferase activity
LWC06_RS03150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LWC06_RS03160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LWC06_RS03170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LWC06_RS03170	COG4499	WXG100 protein secretion system (Wss), protein YukC
LWC06_RS03180	COG0697	spore germination
LWC06_RS03185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LWC06_RS03190	COG0109	protoheme IX farnesyltransferase activity
LWC06_RS03200	COG0166	Belongs to the GPI family
LWC06_RS03210	COG0778	Nitroreductase
LWC06_RS03215	COG0564	pseudouridine synthase activity
LWC06_RS03225	COG1785	Belongs to the alkaline phosphatase family
LWC06_RS03230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWC06_RS03235	COG0488	(ABC) transporter
LWC06_RS03265	COG0733	neurotransmitter:sodium symporter activity
LWC06_RS03270	COG1757	Na H antiporter
LWC06_RS03275	COG0436	Aminotransferase
LWC06_RS03280	COG0028	Belongs to the TPP enzyme family
LWC06_RS03285	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS03295	COG1414	Transcriptional regulator
LWC06_RS03305	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS03315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LWC06_RS03320	COG1077	Cell shape determining protein MreB Mrl
LWC06_RS03325	COG2340	Cysteine-rich secretory protein family
LWC06_RS03330	COG2066	Belongs to the glutaminase family
LWC06_RS03335	COG2135	peptidase activity
LWC06_RS03340	COG1115	amino acid carrier protein
LWC06_RS03350	COG1295	ribonuclease BN
LWC06_RS03355	COG2217	Heavy metal translocating P-type atpase
LWC06_RS03360	COG0477	Major facilitator Superfamily
LWC06_RS03375	COG2056	Na+-H+ antiporter family
LWC06_RS03385	COG3300	MHYT domain
LWC06_RS03385	COG5001	Diguanylate cyclase
LWC06_RS03405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWC06_RS03410	COG0542	response to heat
LWC06_RS03415	COG2333	competence protein COMEC
LWC06_RS03415	COG0658	competence protein
LWC06_RS03425	COG1131	(ABC) transporter
LWC06_RS03435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LWC06_RS03440	COG1131	(ABC) transporter
LWC06_RS03445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LWC06_RS03455	COG2188	Transcriptional regulator
LWC06_RS03480	COG1090	epimerase
LWC06_RS03485	COG2137	regulation of response to DNA damage stimulus
LWC06_RS03490	COG0300	oxidoreductase activity
LWC06_RS03500	COG1988	membrane-bound metal-dependent
LWC06_RS03505	COG1194	a g-specific adenine glycosylase
LWC06_RS03520	COG3557	Belongs to the UPF0374 family
LWC06_RS03525	COG1132	(ABC) transporter
LWC06_RS03530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LWC06_RS03540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LWC06_RS03545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LWC06_RS03550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LWC06_RS03555	COG0735	belongs to the Fur family
LWC06_RS03565	COG0512	Glutamine amidotransferase of anthranilate synthase
LWC06_RS03670	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
LWC06_RS03690	COG0424	maF-like protein
LWC06_RS03700	COG1733	regulation of RNA biosynthetic process
LWC06_RS03710	COG0431	NADPH-dependent FMN reductase
LWC06_RS03715	COG2986	histidine ammonia-lyase
LWC06_RS03720	COG2364	Membrane
LWC06_RS03735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWC06_RS03745	COG1227	inorganic diphosphatase activity
LWC06_RS03765	COG4474	Belongs to the UPF0398 family
LWC06_RS03795	COG0456	acetyltransferase
LWC06_RS03800	COG1794	racemase activity, acting on amino acids and derivatives
LWC06_RS03820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LWC06_RS03860	COG4842	Belongs to the WXG100 family
LWC06_RS03865	COG5417	Belongs to the EsaB family
LWC06_RS03870	COG4499	WXG100 protein secretion system (Wss), protein YukC
LWC06_RS03875	COG0433	COG0433 Predicted ATPase
LWC06_RS03875	COG1674	ftsk spoiiie
LWC06_RS03880	COG1511	domain protein
LWC06_RS03900	COG5444	nuclease activity
LWC06_RS03960	COG2814	Major facilitator Superfamily
LWC06_RS03965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LWC06_RS03970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LWC06_RS03975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LWC06_RS03990	COG4166	transmembrane transport
LWC06_RS03995	COG0277	FAD linked oxidase domain protein
LWC06_RS04010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LWC06_RS04015	COG1011	Hydrolase
LWC06_RS04020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LWC06_RS04035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LWC06_RS04055	COG1714	RDD family
LWC06_RS04060	COG2176	DNA-directed DNA polymerase activity
LWC06_RS04065	COG0616	signal peptide processing
LWC06_RS04070	COG1714	RDD family
LWC06_RS04075	COG0318	PFAM AMP-dependent synthetase and ligase
LWC06_RS04105	COG2233	PERMEase
LWC06_RS04110	COG2814	Major facilitator Superfamily
LWC06_RS04115	COG0697	spore germination
LWC06_RS04130	COG0604	alcohol dehydrogenase
LWC06_RS04140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LWC06_RS04140	COG3320	Male sterility
LWC06_RS04165	COG2318	DinB family
LWC06_RS04175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LWC06_RS04180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LWC06_RS04185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LWC06_RS04190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LWC06_RS04195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LWC06_RS04200	COG4946	Tricorn protease homolog
LWC06_RS04200	COG1506	peptidase
LWC06_RS04200	COG0823	Involved in the tonB-independent uptake of proteins
LWC06_RS04205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LWC06_RS04215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWC06_RS04235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LWC06_RS04250	COG0567	Dehydrogenase, E1 component
LWC06_RS04255	COG0508	dehydrogenase complex catalyzes the overall conversion of
LWC06_RS04260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LWC06_RS04265	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS04270	COG0534	Mate efflux family protein
LWC06_RS04275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LWC06_RS04295	COG0288	reversible hydration of carbon dioxide
LWC06_RS04300	COG1132	(ABC) transporter
LWC06_RS04305	COG1132	(ABC) transporter
LWC06_RS04310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWC06_RS04320	COG1191	sigma factor activity
LWC06_RS04345	COG1854	S-ribosylhomocysteine lyase activity
LWC06_RS04350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LWC06_RS04355	COG0626	cystathionine gamma-synthase activity
LWC06_RS04360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LWC06_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS04380	COG1131	(ABC) transporter
LWC06_RS04385	COG0024	Methionine aminopeptidase
LWC06_RS04395	COG1757	Na H antiporter
LWC06_RS04400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LWC06_RS04410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LWC06_RS04420	COG2270	Major facilitator Superfamily
LWC06_RS04430	COG0114	fumarate hydratase activity
LWC06_RS04440	COG3842	ATPase activity
LWC06_RS04445	COG2508	Transcriptional regulator
LWC06_RS04450	COG3679	Belongs to the UPF0342 family
LWC06_RS04455	COG1024	Enoyl-CoA hydratase
LWC06_RS04465	COG4152	abc transporter atp-binding protein
LWC06_RS04470	COG1668	transmembrane transport
LWC06_RS04475	COG0420	3'-5' exonuclease activity
LWC06_RS04480	COG4717	serine-type aminopeptidase activity
LWC06_RS04485	COG1510	regulation of RNA biosynthetic process
LWC06_RS04490	COG3481	metal-dependent phosphohydrolase, HD sub domain
LWC06_RS04500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LWC06_RS04520	COG1510	regulation of RNA biosynthetic process
LWC06_RS04545	COG4980	gas vesicle protein
LWC06_RS04555	COG0537	adenosine 5'-monophosphoramidase activity
LWC06_RS04560	COG1131	(ABC) transporter
LWC06_RS04565	COG4473	ABC transporter
LWC06_RS04570	COG1473	amidohydrolase
LWC06_RS04575	COG2193	ferroxidase activity
LWC06_RS04585	COG2814	Major facilitator Superfamily
LWC06_RS04595	COG4585	Histidine kinase
LWC06_RS04600	COG2197	response regulator
LWC06_RS04605	COG2329	Antibiotic biosynthesis monooxygenase
LWC06_RS04610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LWC06_RS04615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LWC06_RS04620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LWC06_RS04625	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LWC06_RS04630	COG1164	Oligoendopeptidase f
LWC06_RS04640	COG1234	tRNA 3'-trailer cleavage
LWC06_RS04645	COG0095	Lipoate-protein ligase
LWC06_RS04650	COG0318	PFAM AMP-dependent synthetase and ligase
LWC06_RS04665	COG0398	Pfam SNARE associated Golgi protein
LWC06_RS04675	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LWC06_RS04680	COG1074	ATP-dependent DNA helicase activity
LWC06_RS04690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LWC06_RS04695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LWC06_RS04740	COG2311	Membrane
LWC06_RS04745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LWC06_RS04760	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS04770	COG1307	EDD domain protein, DegV family
LWC06_RS04775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LWC06_RS04800	COG0561	phosphatase activity
LWC06_RS04805	COG1073	alpha beta
LWC06_RS04810	COG2151	metal-sulfur cluster biosynthetic enzyme
LWC06_RS04820	COG0314	molybdopterin synthase activity
LWC06_RS04830	COG2151	metal-sulfur cluster biosynthetic enzyme
LWC06_RS04850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWC06_RS04860	COG0535	radical SAM domain protein
LWC06_RS04865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWC06_RS04890	COG1744	ABC transporter substrate-binding protein PnrA-like
LWC06_RS04895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LWC06_RS04900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LWC06_RS04915	COG0180	Tryptophanyl-tRNA synthetase
LWC06_RS04930	COG1388	LysM domain
LWC06_RS04940	COG0456	acetyltransferase
LWC06_RS04945	COG3258	Cytochrome c
LWC06_RS04950	COG1393	Belongs to the ArsC family
LWC06_RS04955	COG4862	establishment of competence for transformation
LWC06_RS04965	COG1164	Oligoendopeptidase f
LWC06_RS04975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LWC06_RS04980	COG2346	COG2346, Truncated hemoglobins
LWC06_RS04985	COG4116	CYTH
LWC06_RS04990	COG2357	RelA SpoT domain protein
LWC06_RS04995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LWC06_RS05000	COG0564	pseudouridine synthase activity
LWC06_RS05005	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LWC06_RS05010	COG2239	Acts as a magnesium transporter
LWC06_RS05040	COG2323	membrane
LWC06_RS05045	COG2153	protein acetylation
LWC06_RS05050	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LWC06_RS05055	COG2382	esterase
LWC06_RS05060	COG1132	(ABC) transporter
LWC06_RS05065	COG1132	(ABC) transporter
LWC06_RS05080	COG0753	catalase activity
LWC06_RS05085	COG0803	Belongs to the bacterial solute-binding protein 9 family
LWC06_RS05115	COG0436	Aminotransferase
LWC06_RS05120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LWC06_RS05125	COG2011	ABC-type metal ion transport system permease component
LWC06_RS05130	COG1464	Belongs to the NlpA lipoprotein family
LWC06_RS05160	COG0584	glycerophosphoryl diester phosphodiesterase
LWC06_RS05200	COG1360	Flagellar Motor Protein
LWC06_RS05215	COG0488	(ABC) transporter
LWC06_RS05230	COG0584	glycerophosphoryl diester phosphodiesterase
LWC06_RS05235	COG2130	NADP-dependent
LWC06_RS05250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWC06_RS05255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LWC06_RS05270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LWC06_RS05275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LWC06_RS05280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LWC06_RS05285	COG0297	glycogen (starch) synthase activity
LWC06_RS05290	COG0697	spore germination
LWC06_RS05295	COG0814	amino acid
LWC06_RS05330	COG0579	oxidoreductase
LWC06_RS05385	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LWC06_RS05465	COG2258	MOSC domain
LWC06_RS05485	COG0586	Pfam SNARE associated Golgi protein
LWC06_RS05500	COG1714	RDD family
LWC06_RS05520	COG0596	Alpha beta hydrolase
LWC06_RS05535	COG0456	acetyltransferase
LWC06_RS05560	COG1051	belongs to the nudix hydrolase family
LWC06_RS05585	COG1064	alcohol dehydrogenase
LWC06_RS05600	COG0662	Cupin 2, conserved barrel domain protein
LWC06_RS05610	COG0456	acetyltransferase
LWC06_RS05610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LWC06_RS05625	COG5444	nuclease activity
LWC06_RS05665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LWC06_RS05670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWC06_RS05675	COG1120	ATPase activity
LWC06_RS05680	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LWC06_RS05685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LWC06_RS05695	COG1492	cobalamin metabolic process
LWC06_RS05700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LWC06_RS05705	COG0588	phosphoglycerate mutase activity
LWC06_RS05715	COG2096	Adenosyltransferase
LWC06_RS05740	COG1473	amidohydrolase
LWC06_RS05780	COG0477	Major facilitator Superfamily
LWC06_RS05865	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LWC06_RS05990	COG2814	Major facilitator Superfamily
LWC06_RS06010	COG2267	carboxylic ester hydrolase activity
LWC06_RS06020	COG2816	NAD+ diphosphatase activity
LWC06_RS06075	COG1247	-acetyltransferase
LWC06_RS06115	COG3961	Belongs to the TPP enzyme family
LWC06_RS06120	COG1846	Transcriptional regulator
LWC06_RS06130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LWC06_RS06135	COG0346	lactoylglutathione lyase activity
LWC06_RS06185	COG0789	Transcriptional regulator
LWC06_RS06185	COG4978	Transcriptional regulator
LWC06_RS06190	COG1266	CAAX protease self-immunity
LWC06_RS06210	COG2226	methyltransferase
LWC06_RS06295	COG0745	RESPONSE REGULATOR receiver
LWC06_RS06310	COG2205	protein histidine kinase activity
LWC06_RS06320	COG1983	PspC domain protein
LWC06_RS06335	COG2353	YceI-like domain
LWC06_RS06345	COG0346	lactoylglutathione lyase activity
LWC06_RS06350	COG0346	lactoylglutathione lyase activity
LWC06_RS06355	COG1846	Transcriptional regulator
LWC06_RS06375	COG0456	acetyltransferase
LWC06_RS06410	COG2367	Beta-lactamase
LWC06_RS06420	COG1247	-acetyltransferase
LWC06_RS06425	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LWC06_RS06430	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LWC06_RS06435	COG2376	Dihydroxyacetone kinase
LWC06_RS06440	COG1461	Dihydroxyacetone kinase
LWC06_RS06485	COG3279	Response regulator of the LytR AlgR family
LWC06_RS06490	COG0110	maltose O-acetyltransferase activity
LWC06_RS06495	COG1695	Transcriptional regulator
LWC06_RS06505	COG0535	radical SAM domain protein
LWC06_RS06510	COG0531	amino acid
LWC06_RS06515	COG2169	Transcriptional regulator
LWC06_RS06520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LWC06_RS06525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LWC06_RS06535	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LWC06_RS06555	COG2031	fatty acid transporter
LWC06_RS06565	COG0842	Transport permease protein
LWC06_RS06565	COG1129	ABC transporter
LWC06_RS06590	COG0494	nUDIX hydrolase
LWC06_RS06595	COG1061	Type III restriction enzyme res subunit
LWC06_RS06600	COG1061	Type III restriction enzyme res subunit
LWC06_RS06610	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS06620	COG0371	Dehydrogenase
LWC06_RS06650	COG1215	transferase activity, transferring glycosyl groups
LWC06_RS06675	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS06690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LWC06_RS06700	COG0673	inositol 2-dehydrogenase activity
LWC06_RS06760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LWC06_RS06870	COG3655	Transcriptional regulator
LWC06_RS06875	COG3739	integral membrane protein
LWC06_RS06905	COG0406	alpha-ribazole phosphatase activity
LWC06_RS06910	COG0842	Transport permease protein
LWC06_RS06915	COG1131	(ABC) transporter
LWC06_RS06920	COG1619	proteins homologs of microcin C7 resistance protein MccF
LWC06_RS06945	COG0488	(ABC) transporter
LWC06_RS06955	COG3588	fructose-bisphosphate aldolase
LWC06_RS06970	COG0179	Fumarylacetoacetate (FAA) hydrolase
LWC06_RS06985	COG4443	Transcriptional Coactivator p15 (PC4)
LWC06_RS07020	COG1098	S1 RNA binding domain
LWC06_RS07025	COG2112	serine threonine protein kinase
LWC06_RS07030	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS07040	COG3844	kynureninase activity
LWC06_RS07045	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LWC06_RS07055	COG0733	neurotransmitter:sodium symporter activity
LWC06_RS07060	COG0745	RESPONSE REGULATOR receiver
LWC06_RS07075	COG0501	Belongs to the peptidase M48B family
LWC06_RS07100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LWC06_RS07105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LWC06_RS07105	COG0456	acetyltransferase
LWC06_RS07125	COG0667	Aldo Keto reductase
LWC06_RS07135	COG2322	membrane
LWC06_RS07140	COG2226	methyltransferase
LWC06_RS07150	COG2267	carboxylic ester hydrolase activity
LWC06_RS07180	COG1366	Belongs to the anti-sigma-factor antagonist family
LWC06_RS07190	COG1309	transcriptional regulator
LWC06_RS07195	COG2814	Major facilitator Superfamily
LWC06_RS07200	COG2217	Heavy metal translocating P-type atpase
LWC06_RS07215	COG1196	nuclear chromosome segregation
LWC06_RS07215	COG0739	heme binding
LWC06_RS07215	COG0741	lytic transglycosylase activity
LWC06_RS07220	COG2323	membrane
LWC06_RS07230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LWC06_RS07250	COG1309	transcriptional regulator
LWC06_RS07270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWC06_RS07285	COG1063	alcohol dehydrogenase
LWC06_RS07295	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LWC06_RS07330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LWC06_RS07335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LWC06_RS07340	COG1368	sulfuric ester hydrolase activity
LWC06_RS07345	COG0640	Transcriptional regulator
LWC06_RS07350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LWC06_RS07355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LWC06_RS07365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LWC06_RS07390	COG0598	Magnesium transport protein CorA
LWC06_RS07400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LWC06_RS07400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LWC06_RS07405	COG0307	riboflavin synthase, alpha
LWC06_RS07410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWC06_RS07410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWC06_RS07415	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LWC06_RS07440	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LWC06_RS07445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LWC06_RS07475	COG5002	protein histidine kinase activity
LWC06_RS07480	COG0745	RESPONSE REGULATOR receiver
LWC06_RS07490	COG2132	Multicopper oxidase
LWC06_RS07495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LWC06_RS07500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWC06_RS07505	COG0446	pyridine nucleotide-disulphide oxidoreductase
LWC06_RS07520	COG1533	DNA photolyase activity
LWC06_RS07605	COG3311	Transcriptional regulator
LWC06_RS07610	COG0659	secondary active sulfate transmembrane transporter activity
LWC06_RS07620	COG4990	cell redox homeostasis
LWC06_RS07635	COG2329	Antibiotic biosynthesis monooxygenase
LWC06_RS07650	COG1366	Belongs to the anti-sigma-factor antagonist family
LWC06_RS07650	COG2202	Pas domain
LWC06_RS07670	COG1228	amidohydrolase
LWC06_RS07675	COG0530	calcium, potassium:sodium antiporter activity
LWC06_RS07680	COG2314	TM2 domain
LWC06_RS07685	COG1615	UPF0182 protein
LWC06_RS07705	COG5504	Zn-dependent protease
LWC06_RS07725	COG3104	oligopeptide transport
LWC06_RS07755	COG4294	response to UV
LWC06_RS07760	COG0517	IMP dehydrogenase activity
LWC06_RS07780	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LWC06_RS07790	COG2081	HI0933 family
LWC06_RS07795	COG2244	polysaccharide biosynthetic process
LWC06_RS07800	COG1187	pseudouridine synthase activity
LWC06_RS07805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LWC06_RS07815	COG0510	thiamine kinase activity
LWC06_RS07825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LWC06_RS07830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWC06_RS07840	COG1363	Peptidase, m42
LWC06_RS07845	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LWC06_RS07855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWC06_RS07860	COG4848	Belongs to the UPF0354 family
LWC06_RS07865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LWC06_RS07870	COG1674	ftsk spoiiie
LWC06_RS07880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LWC06_RS07890	COG4980	gas vesicle protein
LWC06_RS07895	COG1605	Chorismate mutase
LWC06_RS07895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LWC06_RS07915	COG0123	including yeast histone deacetylase and acetoin utilization protein
LWC06_RS07920	COG0517	IMP dehydrogenase activity
LWC06_RS07925	COG0454	-acetyltransferase
LWC06_RS07930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LWC06_RS07935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LWC06_RS07940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LWC06_RS07945	COG2199	diguanylate cyclase activity
LWC06_RS07945	COG2203	Gaf domain
LWC06_RS07950	COG1956	GAF domain-containing protein
LWC06_RS07955	COG1309	transcriptional regulator
LWC06_RS07960	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LWC06_RS07965	COG1104	cysteine desulfurase activity
LWC06_RS07970	COG0301	tRNA thio-modification
LWC06_RS07980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LWC06_RS07990	COG3874	Sporulation protein YtfJ
LWC06_RS07995	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LWC06_RS08000	COG0827	DNA restriction-modification system
LWC06_RS08005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LWC06_RS08010	COG0521	Mo-molybdopterin cofactor biosynthetic process
LWC06_RS08015	COG0589	response to stress
LWC06_RS08030	COG1842	Phage shock protein A
LWC06_RS08045	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LWC06_RS08050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LWC06_RS08075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LWC06_RS08085	COG1459	type II secretion system
LWC06_RS08095	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LWC06_RS08120	COG4109	DRTGG domain
LWC06_RS08130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LWC06_RS08150	COG0587	DNA-directed DNA polymerase activity
LWC06_RS08155	COG0281	malic enzyme
LWC06_RS08160	COG2186	Transcriptional regulator
LWC06_RS08165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LWC06_RS08170	COG0825	malonyl-CoA metabolic process
LWC06_RS08175	COG0205	6-phosphofructokinase activity
LWC06_RS08185	COG3030	protein affecting phage T7 exclusion by the F plasmid
LWC06_RS08190	COG0628	permease
LWC06_RS08195	COG0372	Belongs to the citrate synthase family
LWC06_RS08200	COG0538	isocitrate dehydrogenase activity
LWC06_RS08205	COG0039	L-malate dehydrogenase activity
LWC06_RS08215	COG0745	RESPONSE REGULATOR receiver
LWC06_RS08220	COG5002	protein histidine kinase activity
LWC06_RS08225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LWC06_RS08225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LWC06_RS08230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LWC06_RS08235	COG0237	dephospho-CoA kinase activity
LWC06_RS08240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LWC06_RS08245	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LWC06_RS08255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LWC06_RS08260	COG3611	Membrane attachment protein
LWC06_RS08265	COG1484	DNA-dependent DNA replication
LWC06_RS08275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LWC06_RS08280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LWC06_RS08285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LWC06_RS08290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LWC06_RS08295	COG3326	Membrane
LWC06_RS08300	COG0398	Pfam SNARE associated Golgi protein
LWC06_RS08315	COG1363	Peptidase, m42
LWC06_RS08320	COG0741	lytic transglycosylase activity
LWC06_RS08325	COG1131	(ABC) transporter
LWC06_RS08350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LWC06_RS08355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LWC06_RS08360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LWC06_RS08360	COG0072	phenylalanine-tRNA ligase activity
LWC06_RS08365	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LWC06_RS08370	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LWC06_RS08375	COG1286	toxin biosynthetic process
LWC06_RS08380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LWC06_RS08380	COG1796	DNA polymerase
LWC06_RS08385	COG1193	negative regulation of DNA recombination
LWC06_RS08390	COG3766	membrane
LWC06_RS08395	COG0318	PFAM AMP-dependent synthetase and ligase
LWC06_RS08400	COG1309	transcriptional regulator
LWC06_RS08405	COG1024	Enoyl-CoA hydratase
LWC06_RS08410	COG2086	electron transfer activity
LWC06_RS08415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LWC06_RS08420	COG3118	belongs to the thioredoxin family
LWC06_RS08425	COG0322	excinuclease ABC activity
LWC06_RS08430	COG1719	4-vinyl reductase, 4VR
LWC06_RS08435	COG2009	succinate dehydrogenase
LWC06_RS08440	COG1053	succinate dehydrogenase
LWC06_RS08445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LWC06_RS08450	COG0824	Thioesterase
LWC06_RS08455	COG2197	response regulator
LWC06_RS08460	COG1846	Transcriptional regulator
LWC06_RS08465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LWC06_RS08470	COG5401	PFAM Sporulation and spore germination
LWC06_RS08475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LWC06_RS08480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LWC06_RS08485	COG0622	Phosphoesterase
LWC06_RS08510	COG0544	peptidyl-prolyl cis-trans isomerase activity
LWC06_RS08515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LWC06_RS08525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LWC06_RS08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWC06_RS08535	COG0765	amino acid transport
LWC06_RS08550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LWC06_RS08555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LWC06_RS08560	COG0181	hydroxymethylbilane synthase activity
LWC06_RS08575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LWC06_RS08580	COG1388	LysM domain
LWC06_RS08580	COG1388	LysM domain
LWC06_RS08595	COG0525	valine-tRNA ligase activity
LWC06_RS08605	COG0189	ligase activity
LWC06_RS08610	COG0285	dihydrofolate synthase activity
LWC06_RS08620	COG2003	Belongs to the UPF0758 family
LWC06_RS08630	COG1077	Cell shape determining protein MreB Mrl
LWC06_RS08645	COG0850	regulation of cytokinetic process
LWC06_RS08650	COG2894	cell division
LWC06_RS08660	COG1994	Peptidase M50
LWC06_RS08665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LWC06_RS08670	COG2868	ribosomal protein
LWC06_RS08685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LWC06_RS08690	COG0077	Prephenate dehydratase
LWC06_RS08695	COG1388	LysM domain
LWC06_RS08705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LWC06_RS08715	COG0217	transcriptional regulatory protein
LWC06_RS08720	COG0632	four-way junction helicase activity
LWC06_RS08725	COG2255	four-way junction helicase activity
LWC06_RS08735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LWC06_RS08740	COG0343	queuine tRNA-ribosyltransferase activity
LWC06_RS08745	COG1862	Preprotein translocase
LWC06_RS08755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LWC06_RS08760	COG2244	polysaccharide biosynthetic process
LWC06_RS08770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LWC06_RS08770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LWC06_RS08775	COG5416	Lipopolysaccharide assembly protein A domain
LWC06_RS08780	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LWC06_RS08780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LWC06_RS08785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LWC06_RS08790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LWC06_RS08795	COG1490	D-aminoacyl-tRNA deacylase activity
LWC06_RS08800	COG4991	sh3 domain protein
LWC06_RS08800	COG3103	Sh3 type 3 domain protein
LWC06_RS08800	COG0860	N-Acetylmuramoyl-L-alanine amidase
LWC06_RS08810	COG0124	histidyl-tRNA synthetase
LWC06_RS08815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LWC06_RS08830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LWC06_RS08835	COG1959	2 iron, 2 sulfur cluster binding
LWC06_RS08840	COG1104	cysteine desulfurase activity
LWC06_RS08845	COG0482	sulfurtransferase activity
LWC06_RS08855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LWC06_RS08865	COG0628	permease
LWC06_RS08870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LWC06_RS08875	COG4472	Bacterial protein of unknown function (DUF965)
LWC06_RS08880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LWC06_RS08885	COG3906	Belongs to the UPF0473 family
LWC06_RS08890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LWC06_RS08895	COG4122	O-methyltransferase activity
LWC06_RS08900	COG0572	uridine kinase
LWC06_RS08905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LWC06_RS08915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LWC06_RS08930	COG1320	monovalent cation:proton antiporter activity
LWC06_RS08935	COG2212	antiporter activity
LWC06_RS08940	COG1863	multisubunit Na H antiporter MnhE subunit
LWC06_RS08945	COG0651	ATP synthesis coupled electron transport
LWC06_RS08950	COG1006	Multisubunit Na H antiporter MnhC subunit
LWC06_RS08955	COG2111	Na H antiporter
LWC06_RS08955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LWC06_RS08965	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LWC06_RS08970	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LWC06_RS08975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LWC06_RS08980	COG1534	Rna-binding protein
LWC06_RS08985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LWC06_RS08990	COG1713	HD superfamily hydrolase involved in NAD metabolism
LWC06_RS08995	COG0799	negative regulation of ribosome biogenesis
LWC06_RS09000	COG2226	methyltransferase
LWC06_RS09005	COG1555	photosystem II stabilization
LWC06_RS09005	COG1596	polysaccharide export
LWC06_RS09010	COG2131	deaminase
LWC06_RS09015	COG0658	competence protein
LWC06_RS09015	COG2333	competence protein COMEC
LWC06_RS09025	COG1466	dna polymerase III delta subunit
LWC06_RS09030	COG0268	Binds directly to 16S ribosomal RNA
LWC06_RS09035	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LWC06_RS09040	COG0860	N-Acetylmuramoyl-L-alanine amidase
LWC06_RS09050	COG0481	GTPase activity
LWC06_RS09055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LWC06_RS09060	COG1420	regulation of RNA biosynthetic process
LWC06_RS09065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LWC06_RS09070	COG0443	Heat shock 70 kDa protein
LWC06_RS09075	COG0484	heat shock protein binding
LWC06_RS09080	COG2264	protein methyltransferase activity
LWC06_RS09085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LWC06_RS09090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LWC06_RS09095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LWC06_RS09100	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LWC06_RS09105	COG1610	YqeY-like protein
LWC06_RS09110	COG1030	water channel activity
LWC06_RS09115	COG4864	UPF0365 protein
LWC06_RS09135	COG1702	phosphate starvation-inducible protein PhoH
LWC06_RS09140	COG1480	7TM receptor with intracellular HD hydrolase
LWC06_RS09145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LWC06_RS09155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LWC06_RS09165	COG1381	Involved in DNA repair and RecF pathway recombination
LWC06_RS09170	COG0752	glycyl-tRNA synthetase alpha subunit
LWC06_RS09175	COG0751	glycine-tRNA ligase activity
LWC06_RS09180	COG0517	IMP dehydrogenase activity
LWC06_RS09185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LWC06_RS09190	COG0358	DNA primase activity
LWC06_RS09195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LWC06_RS09205	COG2384	SAM-dependent methyltransferase
LWC06_RS09210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LWC06_RS09220	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LWC06_RS09230	COG4709	membrane
LWC06_RS09245	COG0704	Plays a role in the regulation of phosphate uptake
LWC06_RS09280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LWC06_RS09285	COG0477	Major facilitator Superfamily
LWC06_RS09290	COG0768	penicillin binding
LWC06_RS09295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LWC06_RS09305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LWC06_RS09310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LWC06_RS09315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LWC06_RS09325	COG0457	Tetratricopeptide repeat
LWC06_RS09325	COG0705	Rhomboid family
LWC06_RS09335	COG0697	spore germination
LWC06_RS09345	COG1940	carbohydrate kinase activity
LWC06_RS09355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWC06_RS09390	COG4537	Required for transformation and DNA binding
LWC06_RS09400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LWC06_RS09415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LWC06_RS09420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LWC06_RS09425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LWC06_RS09430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LWC06_RS09435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWC06_RS09440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWC06_RS09445	COG1321	iron dependent repressor
LWC06_RS09450	COG1752	Esterase of the alpha-beta hydrolase superfamily
LWC06_RS09465	COG0006	proline dipeptidase activity
LWC06_RS09470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LWC06_RS09475	COG3854	ATPases associated with a variety of cellular activities
LWC06_RS09515	COG0511	ligase activity, forming carbon-carbon bonds
LWC06_RS09520	COG0439	Biotin carboxylase
LWC06_RS09525	COG1302	Protein conserved in bacteria
LWC06_RS09530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LWC06_RS09535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LWC06_RS09540	COG1570	exodeoxyribonuclease VII activity
LWC06_RS09545	COG1722	exodeoxyribonuclease VII activity
LWC06_RS09560	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LWC06_RS09565	COG1438	arginine binding
LWC06_RS09570	COG0497	DNA recombination
LWC06_RS09575	COG0750	zinc metalloprotease
LWC06_RS09580	COG0745	RESPONSE REGULATOR receiver
LWC06_RS09585	COG0527	aspartate kinase activity
LWC06_RS09595	COG3290	protein histidine kinase activity
LWC06_RS09595	COG3829	transcription factor binding
LWC06_RS09600	COG0280	phosphate acetyltransferase
LWC06_RS09610	COG3426	butyrate kinase activity
LWC06_RS09615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LWC06_RS09620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LWC06_RS09625	COG0022	dehydrogenase e1 component
LWC06_RS09630	COG0508	dehydrogenase complex catalyzes the overall conversion of
LWC06_RS09640	COG4129	membrane
LWC06_RS09650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LWC06_RS09650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LWC06_RS09655	COG0346	lactoylglutathione lyase activity
LWC06_RS09660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LWC06_RS09665	COG2195	Cleaves the N-terminal amino acid of tripeptides
LWC06_RS09670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LWC06_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS09680	COG1234	tRNA 3'-trailer cleavage
LWC06_RS09685	COG1902	pentaerythritol trinitrate reductase activity
LWC06_RS09690	COG0584	glycerophosphoryl diester phosphodiesterase
LWC06_RS09695	COG4187	Peptidase family M20/M25/M40
LWC06_RS09700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWC06_RS09705	COG0300	oxidoreductase activity
LWC06_RS09715	COG0667	Aldo Keto reductase
LWC06_RS09725	COG1379	DNA repair
LWC06_RS09730	COG1300	Membrane
LWC06_RS09735	COG0735	belongs to the Fur family
LWC06_RS09745	COG4974	Belongs to the 'phage' integrase family
LWC06_RS09750	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LWC06_RS09765	COG1686	Belongs to the peptidase S11 family
LWC06_RS09770	COG1366	Belongs to the anti-sigma-factor antagonist family
LWC06_RS09775	COG2172	sigma factor antagonist activity
LWC06_RS09795	COG0697	spore germination
LWC06_RS09800	COG0019	diaminopimelate decarboxylase activity
LWC06_RS09805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LWC06_RS09815	COG0456	acetyltransferase
LWC06_RS09825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LWC06_RS09830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LWC06_RS09835	COG1686	Belongs to the peptidase S11 family
LWC06_RS09840	COG2715	membrane protein required for spore maturation
LWC06_RS09845	COG0700	Nucleoside recognition
LWC06_RS09850	COG1187	pseudouridine synthase activity
LWC06_RS09855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWC06_RS09860	COG1333	cytochrome c biogenesis protein
LWC06_RS09865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LWC06_RS09870	COG0745	RESPONSE REGULATOR receiver
LWC06_RS09875	COG5002	protein histidine kinase activity
LWC06_RS09885	COG1141	Ferredoxin
LWC06_RS09890	COG4955	Helix-turn-helix domain
LWC06_RS09895	COG0514	ATP-dependent DNA helicase (RecQ)
LWC06_RS09910	COG1408	metallophosphoesterase
LWC06_RS09915	COG4862	establishment of competence for transformation
LWC06_RS09920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LWC06_RS09925	COG0492	ferredoxin-NADP+ reductase activity
LWC06_RS09930	COG0252	asparaginase activity
LWC06_RS09935	COG2339	peptidase activity
LWC06_RS09940	COG3409	Peptidoglycan-binding domain 1 protein
LWC06_RS09940	COG3773	Cell wall hydrolase
LWC06_RS09945	COG2959	enzyme of heme biosynthesis
LWC06_RS09955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LWC06_RS09965	COG0539	negative regulation of cytoplasmic translation
LWC06_RS09985	COG1160	GTP binding
LWC06_RS09990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LWC06_RS10010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LWC06_RS10015	COG0776	regulation of translation
LWC06_RS10025	COG0142	geranyltranstransferase activity
LWC06_RS10030	COG2226	methyltransferase
LWC06_RS10035	COG0142	geranyltranstransferase activity
LWC06_RS10040	COG0105	UTP biosynthetic process
LWC06_RS10045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LWC06_RS10050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LWC06_RS10055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LWC06_RS10060	COG4401	Chorismate mutase type I
LWC06_RS10065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LWC06_RS10070	COG0287	Prephenate dehydrogenase
LWC06_RS10075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LWC06_RS10080	COG0457	Tetratricopeptide repeat
LWC06_RS10085	COG5582	Belongs to the UPF0302 family
LWC06_RS10095	COG0723	plastoquinol--plastocyanin reductase activity
LWC06_RS10100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LWC06_RS10110	COG4347	Protein of unknown function (DUF1405)
LWC06_RS10120	COG2738	Putative neutral zinc metallopeptidase
LWC06_RS10125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LWC06_RS10130	COG1694	Mazg nucleotide pyrophosphohydrolase
LWC06_RS10135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LWC06_RS10140	COG1803	Methylglyoxal synthase
LWC06_RS10145	COG0438	transferase activity, transferring glycosyl groups
LWC06_RS10150	COG0617	tRNA 3'-terminal CCA addition
LWC06_RS10165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LWC06_RS10170	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LWC06_RS10175	COG1199	ATP-dependent helicase activity
LWC06_RS10175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LWC06_RS10190	COG0436	Aminotransferase
LWC06_RS10195	COG0017	Asparaginyl-tRNA synthetase
LWC06_RS10200	COG3935	DnaD domain protein
LWC06_RS10205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LWC06_RS10210	COG4499	WXG100 protein secretion system (Wss), protein YukC
LWC06_RS10210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LWC06_RS10215	COG3331	DNA recombination
LWC06_RS10240	COG0295	cytidine deaminase activity
LWC06_RS10245	COG3599	regulation of cell shape
LWC06_RS10255	COG0116	Belongs to the methyltransferase superfamily
LWC06_RS10260	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LWC06_RS10265	COG3424	synthase
LWC06_RS10270	COG1755	Isoprenylcysteine carboxyl methyltransferase
LWC06_RS10275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LWC06_RS10280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LWC06_RS10295	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LWC06_RS10310	COG1418	mRNA catabolic process
LWC06_RS10315	COG0791	NLP P60 protein
LWC06_RS10315	COG1388	LysM domain
LWC06_RS10320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LWC06_RS10325	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LWC06_RS10330	COG0746	molybdenum cofactor guanylyltransferase activity
LWC06_RS10335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LWC06_RS10340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LWC06_RS10345	COG0805	protein transport
LWC06_RS10350	COG4479	Belongs to the UPF0346 family
LWC06_RS10365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LWC06_RS10365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LWC06_RS10385	COG1254	Belongs to the acylphosphatase family
LWC06_RS10405	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LWC06_RS10410	COG1140	nitrate reductase beta subunit
LWC06_RS10420	COG2181	nitrate reductase activity
LWC06_RS10425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWC06_RS10425	COG0723	plastoquinol--plastocyanin reductase activity
LWC06_RS10430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LWC06_RS10435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWC06_RS10435	COG0723	plastoquinol--plastocyanin reductase activity
LWC06_RS10440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LWC06_RS10445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LWC06_RS10450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LWC06_RS10455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LWC06_RS10460	COG1024	Enoyl-CoA hydratase
LWC06_RS10465	COG0511	ligase activity, forming carbon-carbon bonds
LWC06_RS10470	COG0439	Biotin carboxylase
LWC06_RS10475	COG0318	PFAM AMP-dependent synthetase and ligase
LWC06_RS10480	COG1960	acyl-CoA dehydrogenase activity
LWC06_RS10485	COG1309	transcriptional regulator
LWC06_RS10490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LWC06_RS10495	COG0187	DNA topoisomerase II activity
LWC06_RS10500	COG1832	CoA-binding protein
LWC06_RS10505	COG1174	glycine betaine transport
LWC06_RS10515	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LWC06_RS10520	COG1469	GTP cyclohydrolase I activity
LWC06_RS10525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LWC06_RS10535	COG0824	Thioesterase
LWC06_RS10550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWC06_RS10555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LWC06_RS10560	COG4191	Histidine kinase
LWC06_RS10570	COG4846	Membrane protein involved in cytochrome C biogenesis
LWC06_RS10575	COG2201	protein-glutamate methylesterase activity
LWC06_RS10580	COG2111	Na H antiporter
LWC06_RS10585	COG0785	Cytochrome C biogenesis protein
LWC06_RS10590	COG3763	UPF0154 protein
LWC06_RS10610	COG4224	UPF0291 protein
LWC06_RS10615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LWC06_RS10620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LWC06_RS10625	COG0174	glutamine synthetase
LWC06_RS10630	COG0789	Transcriptional regulator
LWC06_RS10635	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LWC06_RS10640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LWC06_RS10645	COG0464	growth
LWC06_RS10650	COG1923	regulation of RNA biosynthetic process
LWC06_RS10655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LWC06_RS10660	COG0783	Belongs to the Dps family
LWC06_RS10665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LWC06_RS10670	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LWC06_RS10680	COG4550	Control of competence regulator ComK, YlbF/YmcA
LWC06_RS10685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LWC06_RS10690	COG2359	stage V sporulation protein S
LWC06_RS10695	COG1692	metallophosphoesterase
LWC06_RS10700	COG1418	mRNA catabolic process
LWC06_RS10705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LWC06_RS10710	COG1058	Belongs to the CinA family
LWC06_RS10710	COG1546	Belongs to the CinA family
LWC06_RS10715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LWC06_RS10720	COG1426	Protein conserved in bacteria
LWC06_RS10735	COG0300	oxidoreductase activity
LWC06_RS10740	COG0612	Peptidase, M16
LWC06_RS10745	COG0612	Peptidase, M16
LWC06_RS10750	COG1079	Belongs to the binding-protein-dependent transport system permease family
LWC06_RS10755	COG4603	Belongs to the binding-protein-dependent transport system permease family
LWC06_RS10760	COG3845	ABC transporter
LWC06_RS10765	COG1744	ABC transporter substrate-binding protein PnrA-like
LWC06_RS10770	COG2188	Transcriptional regulator
LWC06_RS10775	COG1674	ftsk spoiiie
LWC06_RS10785	COG0740	serine-type endopeptidase activity
LWC06_RS10790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWC06_RS10795	COG0527	aspartate kinase activity
LWC06_RS10800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LWC06_RS10805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LWC06_RS10810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LWC06_RS10815	COG1873	PFAM PRC-barrel domain
LWC06_RS10820	COG0612	Peptidase, M16
LWC06_RS10825	COG0726	polysaccharide deacetylase
LWC06_RS10830	COG1185	polyribonucleotide nucleotidyltransferase activity
LWC06_RS10835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LWC06_RS10840	COG0196	riboflavin kinase activity
LWC06_RS10845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LWC06_RS10850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LWC06_RS10860	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LWC06_RS10865	COG1358	cellular component organization or biogenesis
LWC06_RS10870	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LWC06_RS10875	COG0195	Participates in both transcription termination and antitermination
LWC06_RS10880	COG0779	Required for maturation of 30S ribosomal subunits
LWC06_RS10885	COG1366	Belongs to the anti-sigma-factor antagonist family
LWC06_RS10890	COG2176	DNA-directed DNA polymerase activity
LWC06_RS10895	COG0750	zinc metalloprotease
LWC06_RS10900	COG4589	Belongs to the CDS family
LWC06_RS10905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LWC06_RS10910	COG0233	cytoplasmic translational termination
LWC06_RS10915	COG0528	UMP kinase activity
LWC06_RS10920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LWC06_RS10925	COG0052	Belongs to the universal ribosomal protein uS2 family
LWC06_RS10940	COG1191	sigma factor activity
LWC06_RS10945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LWC06_RS10950	COG1776	CheC inhibitor of MCP methylation
LWC06_RS10955	COG0835	chemotaxis
LWC06_RS10960	COG2201	protein-glutamate methylesterase activity
LWC06_RS10965	COG0455	bacterial-type flagellum organization
LWC06_RS10970	COG1419	protein localization to endoplasmic reticulum
LWC06_RS10975	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LWC06_RS10980	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LWC06_RS10985	COG1684	flagellar biosynthetic protein fliR
LWC06_RS10990	COG1987	bacterial-type flagellum assembly
LWC06_RS10995	COG1338	Plays a role in the flagellum-specific transport system
LWC06_RS11000	COG3190	flagellar
LWC06_RS11005	COG2201	protein-glutamate methylesterase activity
LWC06_RS11010	COG1776	CheC inhibitor of MCP methylation
LWC06_RS11010	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LWC06_RS11015	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LWC06_RS11020	COG1580	Controls the rotational direction of flagella during chemotaxis
LWC06_RS11025	COG1582	Flagellar protein (FlbD)
LWC06_RS11030	COG4786	Flagellar basal body rod
LWC06_RS11040	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LWC06_RS11060	COG1157	protein secretion by the type III secretion system
LWC06_RS11070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LWC06_RS11075	COG1766	The M ring may be actively involved in energy transduction
LWC06_RS11080	COG1677	Flagellar hook-basal body complex protein FliE
LWC06_RS11085	COG1558	bacterial-type flagellum-dependent cell motility
LWC06_RS11090	COG1815	bacterial-type flagellum-dependent cell motility
LWC06_RS11095	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LWC06_RS11100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LWC06_RS11105	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LWC06_RS11110	COG4974	Belongs to the 'phage' integrase family
LWC06_RS11120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LWC06_RS11125	COG0758	DNA mediated transformation
LWC06_RS11130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LWC06_RS11135	COG0045	succinate-CoA ligase (ADP-forming) activity
LWC06_RS11140	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LWC06_RS11150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LWC06_RS11155	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LWC06_RS11165	COG0335	large ribosomal subunit rRNA binding
LWC06_RS11170	COG0336	Belongs to the RNA methyltransferase TrmD family
LWC06_RS11175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LWC06_RS11185	COG1837	Belongs to the UPF0109 family
LWC06_RS11190	COG0228	four-way junction DNA binding
LWC06_RS11195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LWC06_RS11200	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LWC06_RS11205	COG0552	protein localization to endoplasmic reticulum
LWC06_RS11210	COG1196	nuclear chromosome segregation
LWC06_RS11215	COG4840	Belongs to the UPF0435 family
LWC06_RS11220	COG0571	ribonuclease III activity
LWC06_RS11225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LWC06_RS11230	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS11235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LWC06_RS11240	COG0416	fatty acid biosynthetic process
LWC06_RS11245	COG1349	DNA-binding transcription factor activity
LWC06_RS11250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LWC06_RS11255	COG1760	l-serine dehydratase
LWC06_RS11260	COG1760	l-serine dehydratase
LWC06_RS11270	COG1461	Dihydroxyacetone kinase
LWC06_RS11275	COG1302	Protein conserved in bacteria
LWC06_RS11280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LWC06_RS11290	COG1564	THIamine pyrophosphokinase
LWC06_RS11295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LWC06_RS11300	COG1162	GTPase activity
LWC06_RS11305	COG0515	serine threonine protein kinase
LWC06_RS11305	COG2815	serine threonine protein kinase
LWC06_RS11310	COG0631	protein serine/threonine phosphatase activity
LWC06_RS11315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LWC06_RS11315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LWC06_RS11320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LWC06_RS11325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LWC06_RS11330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LWC06_RS11335	COG1758	RNA polymerase activity
LWC06_RS11340	COG0194	GDP metabolic process
LWC06_RS11345	COG2052	Domain of unknown function (DUF370)
LWC06_RS11350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LWC06_RS11360	COG1764	response to oxidative stress
LWC06_RS11365	COG0583	DNA-binding transcription factor activity
LWC06_RS11370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LWC06_RS11375	COG0284	orotidine-5'-phosphate decarboxylase activity
LWC06_RS11380	COG0167	dihydroorotate dehydrogenase activity
LWC06_RS11385	COG0543	2 iron, 2 sulfur cluster binding
LWC06_RS11390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LWC06_RS11395	COG0505	Belongs to the CarA family
LWC06_RS11400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LWC06_RS11405	COG0540	Belongs to the ATCase OTCase family
LWC06_RS11410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LWC06_RS11415	COG0564	pseudouridine synthase activity
LWC06_RS11420	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LWC06_RS11425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LWC06_RS11430	COG3599	regulation of cell shape
LWC06_RS11435	COG2302	S4 RNA-binding domain
LWC06_RS11440	COG0762	integral membrane protein
LWC06_RS11445	COG1799	cell septum assembly
LWC06_RS11450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LWC06_RS11455	COG1496	oxidoreductase activity
LWC06_RS11460	COG1873	PFAM PRC-barrel domain
LWC06_RS11465	COG1191	sigma factor activity
LWC06_RS11470	COG1191	sigma factor activity
LWC06_RS11480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LWC06_RS11485	COG0849	cell division
LWC06_RS11490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LWC06_RS11495	COG0772	Belongs to the SEDS family
LWC06_RS11500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LWC06_RS11505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LWC06_RS11510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LWC06_RS11515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LWC06_RS11520	COG0768	penicillin binding
LWC06_RS11525	COG0768	penicillin binding
LWC06_RS11530	COG4839	cell division protein FtsL
LWC06_RS11535	COG0275	rRNA processing
LWC06_RS11540	COG2001	Belongs to the MraZ family
LWC06_RS11545	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LWC06_RS11555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LWC06_RS11560	COG0454	-acetyltransferase
LWC06_RS11570	COG1024	Enoyl-CoA hydratase
LWC06_RS11575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LWC06_RS11580	COG1399	metal-binding, possibly nucleic acid-binding protein
LWC06_RS11585	COG1323	Belongs to the UPF0348 family
LWC06_RS11590	COG3480	Lon protease (S16) C-terminal proteolytic domain
LWC06_RS11595	COG3314	Sporulation integral membrane protein YlbJ
LWC06_RS11600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LWC06_RS11605	COG0742	ribosomal rna small subunit methyltransferase
LWC06_RS11610	COG4471	UPF0298 protein
LWC06_RS11615	COG3679	Belongs to the UPF0342 family
LWC06_RS11630	COG2340	Cysteine-rich secretory protein family
LWC06_RS11645	COG2322	membrane
LWC06_RS11650	COG3336	cytochrome c oxidase
LWC06_RS11660	COG1845	cytochrome c oxidase, subunit III
LWC06_RS11665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LWC06_RS11675	COG0109	protoheme IX farnesyltransferase activity
LWC06_RS11680	COG1612	heme a metabolic process
LWC06_RS11690	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LWC06_RS11695	COG0772	Belongs to the SEDS family
LWC06_RS11700	COG4838	Belongs to the UPF0358 family
LWC06_RS11705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LWC06_RS11720	COG4896	Protein conserved in bacteria
LWC06_RS11735	COG0483	inositol monophosphate 1-phosphatase activity
LWC06_RS11745	COG4493	Belongs to the UPF0637 family
LWC06_RS11750	COG4476	Belongs to the UPF0223 family
LWC06_RS11760	COG1982	Orn Lys Arg decarboxylase major
LWC06_RS11790	COG0022	dehydrogenase e1 component
LWC06_RS11800	COG0497	DNA recombination
LWC06_RS11805	COG0242	peptide deformylase activity
LWC06_RS11810	COG0561	phosphatase activity
LWC06_RS11815	COG5503	Protein of unknown function (DUF1447)
LWC06_RS11820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LWC06_RS11825	COG0028	Belongs to the TPP enzyme family
LWC06_RS11830	COG0569	domain protein
LWC06_RS11835	COG1132	(ABC) transporter
LWC06_RS11840	COG1132	(ABC) transporter
LWC06_RS11845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWC06_RS11850	COG0450	alkyl hydroperoxide reductase
LWC06_RS11860	COG1473	amidohydrolase
LWC06_RS11865	COG2171	N-acyltransferase activity
LWC06_RS11870	COG0517	IMP dehydrogenase activity
LWC06_RS11875	COG0640	Transcriptional regulator
LWC06_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS11890	COG1408	metallophosphoesterase
LWC06_RS11910	COG0697	spore germination
LWC06_RS11915	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
LWC06_RS11925	COG0436	Aminotransferase
LWC06_RS11935	COG0681	Belongs to the peptidase S26 family
LWC06_RS11945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWC06_RS11955	COG3835	regulator
LWC06_RS11970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWC06_RS11975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LWC06_RS11985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LWC06_RS11990	COG0303	'Molybdopterin
LWC06_RS12015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LWC06_RS12030	COG2323	membrane
LWC06_RS12035	COG1301	dicarboxylic acid transport
LWC06_RS12040	COG0604	alcohol dehydrogenase
LWC06_RS12045	COG0003	Pfam Anion-transporting ATPase
LWC06_RS12055	COG1966	Carbon starvation protein
LWC06_RS12060	COG2427	Protein of unknown function (DUF1641)
LWC06_RS12065	COG3383	formate dehydrogenase (NAD+) activity
LWC06_RS12070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LWC06_RS12075	COG3069	C4-dicarboxylate transmembrane transporter activity
LWC06_RS12085	COG3859	Proton-coupled thiamine transporter YuaJ
LWC06_RS12090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LWC06_RS12110	COG2720	vancomycin resistance protein
LWC06_RS12120	COG1252	NADH dehydrogenase
LWC06_RS12135	COG0318	PFAM AMP-dependent synthetase and ligase
LWC06_RS12170	COG2027	D-alanyl-D-alanine carboxypeptidase
LWC06_RS12180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LWC06_RS12185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LWC06_RS12195	COG1917	Cupin 2, conserved barrel domain protein
LWC06_RS12200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LWC06_RS12215	COG1174	glycine betaine transport
LWC06_RS12220	COG1732	Glycine betaine
LWC06_RS12225	COG1174	glycine betaine transport
LWC06_RS12235	COG1510	regulation of RNA biosynthetic process
LWC06_RS12245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LWC06_RS12255	COG0402	S-adenosylhomocysteine deaminase activity
LWC06_RS12260	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LWC06_RS12265	COG0477	Major facilitator Superfamily
LWC06_RS12280	COG1960	acyl-CoA dehydrogenase activity
LWC06_RS12300	COG2030	dehydratase
LWC06_RS12305	COG1042	CoA-binding domain protein
LWC06_RS12305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWC06_RS12305	COG0045	succinate-CoA ligase (ADP-forming) activity
LWC06_RS12335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWC06_RS12345	COG0495	leucyl-tRNA aminoacylation
LWC06_RS12350	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LWC06_RS12355	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LWC06_RS12360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LWC06_RS12365	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LWC06_RS12370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LWC06_RS12375	COG1116	anion transmembrane transporter activity
LWC06_RS12380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LWC06_RS12385	COG0494	nUDIX hydrolase
LWC06_RS12400	COG1120	ATPase activity
LWC06_RS12405	COG0318	PFAM AMP-dependent synthetase and ligase
LWC06_RS12410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LWC06_RS12415	COG0596	Alpha beta hydrolase
LWC06_RS12420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LWC06_RS12425	COG1169	isochorismate synthase
LWC06_RS12430	COG1575	Belongs to the MenA family. Type 1 subfamily
LWC06_RS12435	COG2050	protein possibly involved in aromatic compounds catabolism
LWC06_RS12440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LWC06_RS12445	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LWC06_RS12450	COG1404	Belongs to the peptidase S8 family
LWC06_RS12450	COG4412	M6 family metalloprotease domain protein
LWC06_RS12465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LWC06_RS12475	COG1098	S1 RNA binding domain
LWC06_RS12480	COG2155	Conserved Protein
LWC06_RS12485	COG0166	Belongs to the GPI family
LWC06_RS12490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LWC06_RS12495	COG2032	superoxide dismutase activity
LWC06_RS12510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWC06_RS12515	COG0813	purine-nucleoside phosphorylase activity
LWC06_RS12520	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LWC06_RS12525	COG3584	3D domain protein
LWC06_RS12535	COG1252	NADH dehydrogenase
LWC06_RS12540	COG0492	ferredoxin-NADP+ reductase activity
LWC06_RS12545	COG0316	Belongs to the HesB IscA family
LWC06_RS12550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LWC06_RS12555	COG4837	Protein of unknown function (DUF1462)
LWC06_RS12565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LWC06_RS12570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LWC06_RS12575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LWC06_RS12580	COG0647	UMP catabolic process
LWC06_RS12590	COG2445	Protein of unknown function DUF86
LWC06_RS12600	COG0154	amidase activity
LWC06_RS12610	COG4470	Protein conserved in bacteria
LWC06_RS12620	COG0739	heme binding
LWC06_RS12630	COG0733	neurotransmitter:sodium symporter activity
LWC06_RS12635	COG1757	Na H antiporter
LWC06_RS12650	COG3377	Domain of unknown function (DUF1805)
LWC06_RS12655	COG0737	Belongs to the 5'-nucleotidase family
LWC06_RS12660	COG0730	response to heat
LWC06_RS12665	COG0719	Fe-S assembly protein
LWC06_RS12670	COG0822	iron-sulfur transferase activity
LWC06_RS12675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LWC06_RS12680	COG0719	Fe-S assembly protein
LWC06_RS12685	COG0396	ATPase activity
LWC06_RS12695	COG1464	Belongs to the NlpA lipoprotein family
LWC06_RS12700	COG2011	ABC-type metal ion transport system permease component
LWC06_RS12705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LWC06_RS12710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWC06_RS12715	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LWC06_RS12720	COG0509	glycine decarboxylation via glycine cleavage system
LWC06_RS12725	COG1393	Belongs to the ArsC family
LWC06_RS12730	COG1960	acyl-CoA dehydrogenase activity
LWC06_RS12735	COG0183	Belongs to the thiolase family
LWC06_RS12740	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWC06_RS12740	COG1024	Enoyl-CoA hydratase
LWC06_RS12745	COG0506	proline dehydrogenase activity
LWC06_RS12755	COG2217	Heavy metal translocating P-type atpase
LWC06_RS12760	COG1937	Protein conserved in bacteria
LWC06_RS12765	COG0803	Belongs to the bacterial solute-binding protein 9 family
LWC06_RS12765	COG3443	Belongs to the bacterial solute-binding protein 9 family
LWC06_RS12770	COG1121	(ABC) transporter
LWC06_RS12775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LWC06_RS12785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LWC06_RS12800	COG3883	PFAM NLP P60 protein
LWC06_RS12800	COG0791	NLP P60 protein
LWC06_RS12805	COG2224	Isocitrate lyase
LWC06_RS12810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LWC06_RS12820	COG4129	membrane
LWC06_RS12825	COG2197	response regulator
LWC06_RS12830	COG4585	Histidine kinase
LWC06_RS12835	COG4758	membrane
LWC06_RS12850	COG2814	Major facilitator Superfamily
LWC06_RS12855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWC06_RS12870	COG1363	Peptidase, m42
LWC06_RS12880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LWC06_RS12885	COG0803	Belongs to the bacterial solute-binding protein 9 family
LWC06_RS12890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LWC06_RS12895	COG1121	(ABC) transporter
LWC06_RS12900	COG0557	exoribonuclease II activity
LWC06_RS12905	COG1647	Serine aminopeptidase, S33
LWC06_RS12910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LWC06_RS12935	COG0148	phosphopyruvate hydratase activity
LWC06_RS12940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LWC06_RS12945	COG0149	triose-phosphate isomerase activity
LWC06_RS12950	COG0126	phosphoglycerate kinase activity
LWC06_RS12970	COG0328	RNA-DNA hybrid ribonuclease activity
LWC06_RS12975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWC06_RS12980	COG3162	membrane
LWC06_RS12985	COG2610	gluconate transmembrane transporter activity
LWC06_RS12990	COG0183	Belongs to the thiolase family
LWC06_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS13000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LWC06_RS13005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LWC06_RS13015	COG0710	3-dehydroquinate dehydratase activity
LWC06_RS13020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LWC06_RS13030	COG0740	serine-type endopeptidase activity
LWC06_RS13035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWC06_RS13040	COG1481	regulation of sporulation
LWC06_RS13045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LWC06_RS13050	COG1660	Displays ATPase and GTPase activities
LWC06_RS13055	COG1051	belongs to the nudix hydrolase family
LWC06_RS13060	COG0492	ferredoxin-NADP+ reductase activity
LWC06_RS13065	COG0457	Tetratricopeptide repeat
LWC06_RS13070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LWC06_RS13075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LWC06_RS13085	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LWC06_RS13090	COG0110	maltose O-acetyltransferase activity
LWC06_RS13095	COG0546	phosphoglycolate phosphatase activity
LWC06_RS13100	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LWC06_RS13105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LWC06_RS13110	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LWC06_RS13115	COG1950	PFAM Membrane protein of
LWC06_RS13120	COG1983	PspC domain protein
LWC06_RS13130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LWC06_RS13140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LWC06_RS13145	COG0556	nucleotide-excision repair
LWC06_RS13155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWC06_RS13160	COG0793	Belongs to the peptidase S41A family
LWC06_RS13160	COG3409	Peptidoglycan-binding domain 1 protein
LWC06_RS13165	COG0739	heme binding
LWC06_RS13170	COG2177	Part of the ABC transporter FtsEX involved in
LWC06_RS13175	COG2884	Cell division ATP-binding protein ftsE
LWC06_RS13190	COG0653	protein targeting
LWC06_RS13200	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LWC06_RS13210	COG1516	flagellar protein fliS
LWC06_RS13215	COG1334	flagellar protein FlaG
LWC06_RS13220	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LWC06_RS13225	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
LWC06_RS13235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LWC06_RS13240	COG1256	bacterial-type flagellum assembly
LWC06_RS13240	COG4786	Flagellar basal body rod
LWC06_RS13260	COG1040	competence protein
LWC06_RS13265	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LWC06_RS13270	COG1307	EDD domain protein, DegV family
LWC06_RS13275	COG2197	response regulator
LWC06_RS13285	COG1739	Uncharacterized protein family UPF0029
LWC06_RS13290	COG0363	glucosamine-6-phosphate deaminase activity
LWC06_RS13295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LWC06_RS13300	COG1263	PTS System
LWC06_RS13300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LWC06_RS13300	COG2190	(PTS) system
LWC06_RS13315	COG1396	sequence-specific DNA binding
LWC06_RS13330	COG0681	Belongs to the peptidase S26 family
LWC06_RS13350	COG3764	Sortase (surface protein transpeptidase)
LWC06_RS13355	COG1316	TRANSCRIPTIONal
LWC06_RS13360	COG0768	penicillin binding
LWC06_RS13380	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS13390	COG0561	phosphatase activity
LWC06_RS13395	COG2814	Major facilitator Superfamily
LWC06_RS13400	COG1984	allophanate hydrolase subunit 2
LWC06_RS13405	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LWC06_RS13410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LWC06_RS13415	COG0471	metal ion transport
LWC06_RS13420	COG2814	Major facilitator Superfamily
LWC06_RS13425	COG2807	transmembrane transport
LWC06_RS13435	COG1368	sulfuric ester hydrolase activity
LWC06_RS13440	COG0840	transmembrane signaling receptor activity
LWC06_RS13450	COG0840	transmembrane signaling receptor activity
LWC06_RS13455	COG2200	EAL domain
LWC06_RS13460	COG2201	protein-glutamate methylesterase activity
LWC06_RS13465	COG0835	chemotaxis
LWC06_RS13470	COG0643	Histidine kinase
LWC06_RS13470	COG2198	Histidine kinase
LWC06_RS13480	COG1360	Flagellar Motor Protein
LWC06_RS13485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LWC06_RS13490	COG0840	transmembrane signaling receptor activity
LWC06_RS13495	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS13500	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LWC06_RS13540	COG0840	transmembrane signaling receptor activity
LWC06_RS13550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWC06_RS13555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LWC06_RS13560	COG1472	Belongs to the glycosyl hydrolase 3 family
LWC06_RS13565	COG3876	Protein conserved in bacteria
LWC06_RS13570	COG0395	ABC-type sugar transport system, permease component
LWC06_RS13575	COG1175	transmembrane transport
LWC06_RS13585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LWC06_RS13590	COG1737	Transcriptional regulator
LWC06_RS13595	COG0716	FMN binding
LWC06_RS13610	COG1331	Highly conserved protein containing a thioredoxin domain
LWC06_RS13640	COG1971	Probably functions as a manganese efflux pump
LWC06_RS13655	COG2996	Protein conserved in bacteria
LWC06_RS13665	COG4895	conserved protein (DUF2196)
LWC06_RS13680	COG0561	phosphatase activity
LWC06_RS13700	COG4565	transcriptional regulatory protein
LWC06_RS13705	COG3290	protein histidine kinase activity
LWC06_RS13710	COG2271	Major facilitator Superfamily
LWC06_RS13715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LWC06_RS13730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LWC06_RS13750	COG0601	transmembrane transport
LWC06_RS13755	COG4608	Belongs to the ABC transporter superfamily
LWC06_RS13765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LWC06_RS13775	COG0463	Glycosyl transferase, family 2
LWC06_RS13785	COG2076	Multidrug Resistance protein
LWC06_RS13790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LWC06_RS13800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LWC06_RS13810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LWC06_RS13815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LWC06_RS13820	COG0066	3-isopropylmalate dehydratase activity
LWC06_RS13825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LWC06_RS13830	COG0473	3-isopropylmalate dehydrogenase activity
LWC06_RS13835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LWC06_RS13840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LWC06_RS13845	COG0440	acetolactate synthase activity
LWC06_RS13850	COG0028	Belongs to the TPP enzyme family
LWC06_RS13855	COG0129	dihydroxy-acid dehydratase activity
LWC06_RS13860	COG0385	Bile acid
LWC06_RS13865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LWC06_RS13875	COG0473	3-isopropylmalate dehydrogenase activity
LWC06_RS13880	COG1757	Na H antiporter
LWC06_RS13885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LWC06_RS13895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LWC06_RS13900	COG1473	amidohydrolase
LWC06_RS13905	COG0251	oxidation-reduction process
LWC06_RS13910	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS13915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LWC06_RS13920	COG1802	Transcriptional regulator
LWC06_RS13925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LWC06_RS13930	COG0006	proline dipeptidase activity
LWC06_RS13935	COG0833	amino acid
LWC06_RS13940	COG0656	L-ascorbic acid biosynthetic process
LWC06_RS13960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LWC06_RS13965	COG0805	protein transport
LWC06_RS13970	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LWC06_RS13980	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS13990	COG0860	N-Acetylmuramoyl-L-alanine amidase
LWC06_RS14000	COG0583	DNA-binding transcription factor activity
LWC06_RS14005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LWC06_RS14010	COG0686	Belongs to the AlaDH PNT family
LWC06_RS14015	COG2188	Transcriptional regulator
LWC06_RS14020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LWC06_RS14030	COG0765	amino acid transport
LWC06_RS14035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWC06_RS14040	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS14045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LWC06_RS14050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LWC06_RS14060	COG3258	Cytochrome c
LWC06_RS14065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LWC06_RS14065	COG2010	Cytochrome c
LWC06_RS14070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LWC06_RS14095	COG0419	ATPase involved in DNA repair
LWC06_RS14100	COG0420	3'-5' exonuclease activity
LWC06_RS14115	COG0628	permease
LWC06_RS14120	COG1846	Transcriptional regulator
LWC06_RS14125	COG2814	Major facilitator Superfamily
LWC06_RS14130	COG0351	phosphomethylpyrimidine kinase
LWC06_RS14135	COG4619	ABC transporter
LWC06_RS14140	COG0390	transport system, permease component
LWC06_RS14155	COG2706	6-phosphogluconolactonase activity
LWC06_RS14170	COG0516	GMP reductase activity
LWC06_RS14180	COG0010	Belongs to the arginase family
LWC06_RS14185	COG0786	glutamate:sodium symporter activity
LWC06_RS14190	COG1105	Belongs to the carbohydrate kinase PfkB family
LWC06_RS14195	COG3684	Belongs to the aldolase LacD family
LWC06_RS14210	COG3716	PTS system mannose fructose sorbose family IID component
LWC06_RS14215	COG3715	PTS system
LWC06_RS14220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LWC06_RS14225	COG2222	sugar isomerase
LWC06_RS14230	COG2188	Transcriptional regulator
LWC06_RS14240	COG1929	Belongs to the glycerate kinase type-1 family
LWC06_RS14250	COG3119	arylsulfatase activity
LWC06_RS14260	COG5426	von Willebrand factor, type A
LWC06_RS14265	COG0395	ABC-type sugar transport system, permease component
LWC06_RS14270	COG1175	transmembrane transport
LWC06_RS14275	COG1653	transport
LWC06_RS14280	COG2207	Transcriptional regulator
LWC06_RS14280	COG1917	Cupin 2, conserved barrel domain protein
LWC06_RS14285	COG4166	transmembrane transport
LWC06_RS14295	COG1609	Transcriptional regulator
LWC06_RS14305	COG1316	TRANSCRIPTIONal
LWC06_RS14310	COG4166	transmembrane transport
LWC06_RS14335	COG1562	ergosterol biosynthetic process
LWC06_RS14350	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LWC06_RS14355	COG0840	transmembrane signaling receptor activity
LWC06_RS14370	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LWC06_RS14380	COG0006	proline dipeptidase activity
LWC06_RS14395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LWC06_RS14400	COG2223	nitrite transmembrane transporter activity
LWC06_RS14410	COG0405	Gamma-glutamyltransferase
LWC06_RS14425	COG3764	Sortase (surface protein transpeptidase)
LWC06_RS14435	COG1268	BioY protein
LWC06_RS14450	COG1757	Na H antiporter
LWC06_RS14455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LWC06_RS14460	COG3290	protein histidine kinase activity
LWC06_RS14460	COG3829	transcription factor binding
LWC06_RS14465	COG3383	formate dehydrogenase (NAD+) activity
LWC06_RS14470	COG5609	conserved protein (DUF2294)
LWC06_RS14475	COG3223	Belongs to the PsiE family
LWC06_RS14480	COG1917	Cupin 2, conserved barrel domain protein
LWC06_RS14480	COG1396	sequence-specific DNA binding
LWC06_RS14485	COG5505	Protein of unknown function (DUF819)
LWC06_RS14495	COG0431	NADPH-dependent FMN reductase
LWC06_RS14500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWC06_RS14510	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS14520	COG1228	amidohydrolase
LWC06_RS14545	COG3541	Predicted nucleotidyltransferase
LWC06_RS14560	COG1404	Belongs to the peptidase S8 family
LWC06_RS14565	COG2814	Major facilitator Superfamily
LWC06_RS14575	COG4948	Mandelate Racemase Muconate Lactonizing
LWC06_RS14580	COG1404	Belongs to the peptidase S8 family
LWC06_RS14585	COG2027	D-alanyl-D-alanine carboxypeptidase
LWC06_RS14590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LWC06_RS14600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWC06_RS14605	COG3291	Pkd domain containing protein
LWC06_RS14605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LWC06_RS14610	COG1556	Lactate utilization protein
LWC06_RS14615	COG1139	Iron-sulfur cluster binding protein
LWC06_RS14620	COG0247	lactate metabolic process
LWC06_RS14625	COG2186	Transcriptional regulator
LWC06_RS14640	COG1737	Transcriptional regulator
LWC06_RS14645	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LWC06_RS14655	COG2190	(PTS) system
LWC06_RS14665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWC06_RS14670	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LWC06_RS14680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LWC06_RS14690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LWC06_RS14695	COG0657	acetylesterase activity
LWC06_RS14760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LWC06_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS14775	COG1215	transferase activity, transferring glycosyl groups
LWC06_RS14795	COG2197	response regulator
LWC06_RS14815	COG2368	4-hydroxyphenylacetate
LWC06_RS14820	COG1132	(ABC) transporter
LWC06_RS14830	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS14835	COG0840	transmembrane signaling receptor activity
LWC06_RS14845	COG1609	Transcriptional regulator
LWC06_RS14860	COG2233	PERMEase
LWC06_RS14865	COG0402	S-adenosylhomocysteine deaminase activity
LWC06_RS14875	COG3775	system Galactitol-specific IIC component
LWC06_RS14885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LWC06_RS14890	COG2022	thiamine diphosphate biosynthetic process
LWC06_RS14900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWC06_RS14905	COG0352	thiamine-phosphate diphosphorylase activity
LWC06_RS14915	COG0549	Belongs to the carbamate kinase family
LWC06_RS14920	COG1304	FMN binding
LWC06_RS14925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LWC06_RS14935	COG1335	isochorismatase
LWC06_RS14950	COG2508	Transcriptional regulator
LWC06_RS14955	COG3250	beta-galactosidase activity
LWC06_RS14960	COG0531	amino acid
LWC06_RS14965	COG2207	Transcriptional regulator
LWC06_RS14970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LWC06_RS14985	COG1737	Transcriptional regulator
LWC06_RS14990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LWC06_RS14995	COG3876	Protein conserved in bacteria
LWC06_RS15000	COG1472	Belongs to the glycosyl hydrolase 3 family
LWC06_RS15005	COG0395	ABC-type sugar transport system, permease component
LWC06_RS15010	COG1175	transmembrane transport
LWC06_RS15020	COG3344	reverse transcriptase
LWC06_RS15025	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LWC06_RS15050	COG3842	ATPase activity
LWC06_RS15060	COG2972	Histidine kinase
LWC06_RS15065	COG4753	response regulator
LWC06_RS15065	COG2207	Transcriptional regulator
LWC06_RS15085	COG1454	alcohol dehydrogenase
LWC06_RS15090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LWC06_RS15090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LWC06_RS15100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LWC06_RS15105	COG2188	Transcriptional regulator
LWC06_RS15115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LWC06_RS15130	COG2514	catechol 2,3-dioxygenase activity
LWC06_RS15135	COG1733	regulation of RNA biosynthetic process
LWC06_RS15140	COG3119	arylsulfatase activity
LWC06_RS15170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LWC06_RS15175	COG0583	DNA-binding transcription factor activity
LWC06_RS15180	COG0730	response to heat
LWC06_RS15200	COG1846	Transcriptional regulator
LWC06_RS15205	COG1033	growth of symbiont in host cell
LWC06_RS15205	COG2409	Drug exporters of the RND superfamily
LWC06_RS15220	COG4166	transmembrane transport
LWC06_RS15240	COG1595	DNA-templated transcription, initiation
LWC06_RS15260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWC06_RS15265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWC06_RS15270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LWC06_RS15285	COG0681	Belongs to the peptidase S26 family
LWC06_RS15320	COG0366	Alpha amylase catalytic
LWC06_RS15325	COG3345	alpha-galactosidase
LWC06_RS15340	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS15345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWC06_RS15350	COG1757	Na H antiporter
LWC06_RS15360	COG3938	Belongs to the proline racemase family
LWC06_RS15365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWC06_RS15395	COG2362	D-Aminopeptidase
LWC06_RS15405	COG4608	Belongs to the ABC transporter superfamily
LWC06_RS15410	COG0444	Belongs to the ABC transporter superfamily
LWC06_RS15415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LWC06_RS15420	COG0601	transmembrane transport
LWC06_RS15425	COG0747	negative chemotaxis
LWC06_RS15435	COG0366	Alpha amylase catalytic
LWC06_RS15445	COG1609	Transcriptional regulator
LWC06_RS15460	COG1653	transport
LWC06_RS15475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LWC06_RS15490	COG2723	6-phospho-beta-galactosidase activity
LWC06_RS15495	COG1486	melibiose metabolic process
LWC06_RS15500	COG1447	Phosphotransferase system cellobiose-specific component IIA
LWC06_RS15505	COG3711	transcriptional antiterminator
LWC06_RS15505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWC06_RS15510	COG2936	dipeptidyl-peptidase activity
LWC06_RS15525	COG0174	glutamine synthetase
LWC06_RS15530	COG0493	'glutamate synthase
LWC06_RS15535	COG0067	glutamate synthase
LWC06_RS15535	COG0069	glutamate synthase activity
LWC06_RS15535	COG0070	glutamate synthase
LWC06_RS15540	COG0583	DNA-binding transcription factor activity
LWC06_RS15545	COG0367	asparagine synthase
LWC06_RS15550	COG0446	pyridine nucleotide-disulphide oxidoreductase
LWC06_RS15605	COG1192	Involved in chromosome partitioning
LWC06_RS15630	COG3949	Membrane
LWC06_RS15635	COG4948	Mandelate Racemase Muconate Lactonizing
LWC06_RS15645	COG1473	amidohydrolase
LWC06_RS15655	COG1476	TRANSCRIPTIONal
LWC06_RS15665	COG0840	transmembrane signaling receptor activity
LWC06_RS15710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LWC06_RS15715	COG1396	sequence-specific DNA binding
LWC06_RS15735	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LWC06_RS15740	COG0583	DNA-binding transcription factor activity
LWC06_RS15755	COG3157	Type VI secretion system effector, Hcp
LWC06_RS15780	COG5444	nuclease activity
LWC06_RS15790	COG5444	nuclease activity
LWC06_RS15825	COG0606	chelatase, subunit chli
LWC06_RS15850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LWC06_RS15855	COG2089	acid synthase
LWC06_RS15860	COG0110	maltose O-acetyltransferase activity
LWC06_RS15865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LWC06_RS15870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LWC06_RS15875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LWC06_RS15900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LWC06_RS15920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LWC06_RS15925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LWC06_RS15935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LWC06_RS15955	COG4464	protein tyrosine phosphatase activity
LWC06_RS15960	COG0489	protein tyrosine kinase activity
LWC06_RS15965	COG3944	biosynthesis protein
LWC06_RS15970	COG0791	NLP P60 protein
LWC06_RS15970	COG1388	LysM domain
LWC06_RS15990	COG0165	Argininosuccinate lyase
LWC06_RS16000	COG3842	ATPase activity
LWC06_RS16005	COG1840	ABC-type Fe3 transport system, periplasmic component
LWC06_RS16020	COG1940	carbohydrate kinase activity
LWC06_RS16030	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWC06_RS16035	COG1482	cell wall glycoprotein biosynthetic process
LWC06_RS16040	COG1940	carbohydrate kinase activity
LWC06_RS16050	COG1175	transmembrane transport
LWC06_RS16060	COG4753	response regulator
LWC06_RS16060	COG2207	Transcriptional regulator
LWC06_RS16065	COG2972	Histidine kinase
LWC06_RS16070	COG1879	ABC-type sugar transport system periplasmic component
LWC06_RS16080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LWC06_RS16095	COG1069	ribulokinase activity
LWC06_RS16105	COG1070	Carbohydrate kinase
LWC06_RS16110	COG0235	Class ii aldolase
LWC06_RS16125	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWC06_RS16135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LWC06_RS16145	COG1349	DNA-binding transcription factor activity
LWC06_RS16150	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS16150	COG3347	Dehydrogenase
LWC06_RS16165	COG1609	Transcriptional regulator
LWC06_RS16175	COG3142	Participates in the control of copper homeostasis
LWC06_RS16180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LWC06_RS16185	COG4166	transmembrane transport
LWC06_RS16200	COG0395	ABC-type sugar transport system, permease component
LWC06_RS16205	COG1175	transmembrane transport
LWC06_RS16210	COG2182	Extracellular solute-binding protein
LWC06_RS16215	COG1940	carbohydrate kinase activity
LWC06_RS16220	COG1940	carbohydrate kinase activity
LWC06_RS16235	COG3711	transcriptional antiterminator
LWC06_RS16245	COG0432	Pfam Uncharacterised protein family UPF0047
LWC06_RS16250	COG2972	Histidine kinase
LWC06_RS16250	COG0745	RESPONSE REGULATOR receiver
LWC06_RS16290	COG1316	TRANSCRIPTIONal
LWC06_RS16295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LWC06_RS16300	COG0438	transferase activity, transferring glycosyl groups
LWC06_RS16310	COG1216	Glycosyl transferase, family 2
LWC06_RS16330	COG0584	glycerophosphoryl diester phosphodiesterase
LWC06_RS16345	COG1682	transport, permease protein
LWC06_RS16355	COG0438	transferase activity, transferring glycosyl groups
LWC06_RS16370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LWC06_RS16375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LWC06_RS16380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LWC06_RS16385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LWC06_RS16390	COG1368	sulfuric ester hydrolase activity
LWC06_RS16410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LWC06_RS16415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LWC06_RS16420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LWC06_RS16425	COG0011	TIGRFAM Protein of
LWC06_RS16430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LWC06_RS16450	COG2076	Multidrug Resistance protein
LWC06_RS16455	COG2076	Multidrug Resistance protein
LWC06_RS16465	COG1447	Phosphotransferase system cellobiose-specific component IIA
LWC06_RS16475	COG1486	melibiose metabolic process
LWC06_RS16480	COG2188	Transcriptional regulator
LWC06_RS16485	COG3394	polysaccharide catabolic process
LWC06_RS16505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LWC06_RS16510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LWC06_RS16520	COG1309	transcriptional regulator
LWC06_RS16530	COG4980	gas vesicle protein
LWC06_RS16540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LWC06_RS16555	COG4786	Flagellar basal body rod
LWC06_RS16560	COG4786	Flagellar basal body rod
LWC06_RS16565	COG1077	Cell shape determining protein MreB Mrl
LWC06_RS16575	COG1609	Transcriptional regulator
LWC06_RS16585	COG0739	heme binding
LWC06_RS16590	COG2385	sporulation resulting in formation of a cellular spore
LWC06_RS16595	COG4608	Belongs to the ABC transporter superfamily
LWC06_RS16600	COG0791	NLP P60 protein
LWC06_RS16605	COG4948	Mandelate Racemase Muconate Lactonizing
LWC06_RS16610	COG1619	proteins homologs of microcin C7 resistance protein MccF
LWC06_RS16615	COG4166	transmembrane transport
LWC06_RS16620	COG0444	Belongs to the ABC transporter superfamily
LWC06_RS16625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LWC06_RS16630	COG0601	transmembrane transport
LWC06_RS16635	COG2362	D-Aminopeptidase
LWC06_RS16640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LWC06_RS16655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LWC06_RS16660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LWC06_RS16665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LWC06_RS16670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LWC06_RS16675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LWC06_RS16680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LWC06_RS16685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LWC06_RS16690	COG0356	it plays a direct role in the translocation of protons across the membrane
LWC06_RS16700	COG1404	Belongs to the peptidase S8 family
LWC06_RS16705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LWC06_RS16710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LWC06_RS16715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LWC06_RS16720	COG4475	Protein of unknown function (DUF436)
LWC06_RS16725	COG0698	ribose 5-phosphate isomerase
LWC06_RS16735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LWC06_RS16740	COG1971	Probably functions as a manganese efflux pump
LWC06_RS16755	COG0009	L-threonylcarbamoyladenylate synthase
LWC06_RS16770	COG2890	protein-(glutamine-N5) methyltransferase activity
LWC06_RS16775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LWC06_RS16780	COG1435	thymidine kinase activity
LWC06_RS16785	COG0254	rRNA binding
LWC06_RS16790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LWC06_RS16795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LWC06_RS16800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LWC06_RS16805	COG0191	fructose-bisphosphate aldolase activity
LWC06_RS16815	COG0504	CTP synthase activity
LWC06_RS16820	COG3343	RNA polymerase activity
LWC06_RS16830	COG1703	isobutyryl-CoA mutase activity
LWC06_RS16830	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LWC06_RS16830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LWC06_RS16840	COG1703	isobutyryl-CoA mutase activity
LWC06_RS16845	COG1960	acyl-CoA dehydrogenase activity
LWC06_RS16850	COG1960	acyl-CoA dehydrogenase activity
LWC06_RS16855	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWC06_RS16860	COG0183	Belongs to the thiolase family
LWC06_RS16865	COG2181	nitrate reductase activity
LWC06_RS16865	COG0247	lactate metabolic process
LWC06_RS16870	COG0018	arginyl-trna synthetase
LWC06_RS16880	COG0010	Belongs to the arginase family
LWC06_RS16885	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LWC06_RS16890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LWC06_RS16900	COG3465	dGTPase activity
LWC06_RS16905	COG1078	dGTPase activity
LWC06_RS16910	COG0095	Lipoate-protein ligase
LWC06_RS16915	COG0280	phosphate acetyltransferase
LWC06_RS16920	COG3253	May function as heme-dependent peroxidase
LWC06_RS16935	COG2363	Small membrane protein
LWC06_RS16950	COG0069	glutamate synthase activity
LWC06_RS16965	COG3314	Sporulation integral membrane protein YlbJ
LWC06_RS16975	COG3594	Acyltransferase
LWC06_RS16980	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LWC06_RS16985	COG1793	dna ligase
LWC06_RS16985	COG3285	dna ligase
LWC06_RS16995	COG1764	response to oxidative stress
LWC06_RS17010	COG3189	MarR family transcriptional regulator
LWC06_RS17015	COG0861	Integral membrane protein TerC family
LWC06_RS17020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LWC06_RS17025	COG0628	permease
LWC06_RS17045	COG1114	Component of the transport system for branched-chain amino acids
LWC06_RS17050	COG0514	ATP-dependent DNA helicase (RecQ)
LWC06_RS17060	COG1115	amino acid carrier protein
LWC06_RS17065	COG1607	acyl-coa hydrolase
LWC06_RS17070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LWC06_RS17075	COG0626	cystathionine gamma-synthase activity
LWC06_RS17080	COG2962	Rard protein
LWC06_RS17085	COG2873	o-acetylhomoserine
LWC06_RS17090	COG2755	lipolytic protein G-D-S-L family
LWC06_RS17095	COG4698	Protein conserved in bacteria
LWC06_RS17115	COG0488	(ABC) transporter
LWC06_RS17120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LWC06_RS17125	COG0156	8-amino-7-oxononanoate synthase activity
LWC06_RS17130	COG1388	LysM domain
LWC06_RS17130	COG3584	3D domain protein
LWC06_RS17130	COG3584	3D domain protein
LWC06_RS17130	COG1388	LysM domain
LWC06_RS17135	COG4086	secreted protein
LWC06_RS17140	COG2814	Major facilitator Superfamily
LWC06_RS17150	COG1979	alcohol dehydrogenase
LWC06_RS17155	COG0251	oxidation-reduction process
LWC06_RS17160	COG0741	lytic transglycosylase activity
LWC06_RS17170	COG0534	Mate efflux family protein
LWC06_RS17185	COG2358	TRAP transporter, solute receptor (TAXI family
LWC06_RS17190	COG0318	PFAM AMP-dependent synthetase and ligase
LWC06_RS17195	COG4608	Belongs to the ABC transporter superfamily
LWC06_RS17200	COG0444	Belongs to the ABC transporter superfamily
LWC06_RS17205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LWC06_RS17210	COG0601	transmembrane transport
LWC06_RS17215	COG4166	transmembrane transport
LWC06_RS17225	COG2070	2-Nitropropane dioxygenase
LWC06_RS17240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LWC06_RS17245	COG2814	Major facilitator Superfamily
LWC06_RS17250	COG1737	Transcriptional regulator
LWC06_RS17255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LWC06_RS17260	COG2610	gluconate transmembrane transporter activity
LWC06_RS17265	COG1070	Carbohydrate kinase
LWC06_RS17275	COG1288	antiporter activity
LWC06_RS17280	COG2032	superoxide dismutase activity
LWC06_RS17290	COG1725	Transcriptional regulator
LWC06_RS17295	COG4152	abc transporter atp-binding protein
LWC06_RS17310	COG0655	NAD(P)H dehydrogenase (quinone) activity
LWC06_RS17315	COG3103	Sh3 type 3 domain protein
LWC06_RS17315	COG4991	sh3 domain protein
LWC06_RS17315	COG0860	N-Acetylmuramoyl-L-alanine amidase
LWC06_RS17325	COG2226	methyltransferase
LWC06_RS17345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWC06_RS17360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWC06_RS17370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWC06_RS17375	COG0583	DNA-binding transcription factor activity
LWC06_RS17380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LWC06_RS17385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LWC06_RS17410	COG3246	L-lysine catabolic process to acetate
LWC06_RS17415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LWC06_RS17420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWC06_RS17425	COG2323	membrane
LWC06_RS17430	COG0367	asparagine synthase
LWC06_RS17440	COG1595	DNA-templated transcription, initiation
LWC06_RS17445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LWC06_RS17460	COG1115	amino acid carrier protein
LWC06_RS17465	COG0753	catalase activity
LWC06_RS17470	COG2199	diguanylate cyclase activity
LWC06_RS17480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LWC06_RS17485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LWC06_RS17490	COG0655	NAD(P)H dehydrogenase (quinone) activity
LWC06_RS17495	COG0501	Belongs to the peptidase M48B family
LWC06_RS17500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LWC06_RS17505	COG2197	response regulator
LWC06_RS17510	COG4585	Histidine kinase
LWC06_RS17515	COG3239	Fatty acid desaturase
LWC06_RS17530	COG1199	ATP-dependent helicase activity
LWC06_RS17535	COG0427	acetyl-CoA hydrolase
LWC06_RS17540	COG3279	Response regulator of the LytR AlgR family
LWC06_RS17550	COG1252	NADH dehydrogenase
LWC06_RS17555	COG1346	cytolysis
LWC06_RS17560	COG1380	Effector of murein hydrolase LrgA
LWC06_RS17565	COG0165	Argininosuccinate lyase
LWC06_RS17570	COG0137	argininosuccinate synthase activity
LWC06_RS17575	COG2076	Multidrug Resistance protein
LWC06_RS17585	COG1309	transcriptional regulator
LWC06_RS17590	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS17605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LWC06_RS17610	COG0573	inorganic phosphate transmembrane transporter activity
LWC06_RS17615	COG0581	inorganic phosphate transmembrane transporter activity
LWC06_RS17620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LWC06_RS17645	COG2323	membrane
LWC06_RS17655	COG2814	Major facilitator Superfamily
LWC06_RS17660	COG2404	hydrolase activity, acting on ester bonds
LWC06_RS17675	COG1595	DNA-templated transcription, initiation
LWC06_RS17695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWC06_RS17700	COG1609	Transcriptional regulator
LWC06_RS17710	COG1621	beta-fructofuranosidase activity
LWC06_RS17715	COG2190	(PTS) system
LWC06_RS17720	COG3871	stress protein (general stress protein 26)
LWC06_RS17725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWC06_RS17740	COG1609	Transcriptional regulator
LWC06_RS17745	COG0709	Synthesizes selenophosphate from selenide and ATP
LWC06_RS17750	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LWC06_RS17760	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LWC06_RS17785	COG1607	acyl-coa hydrolase
LWC06_RS17810	COG0583	DNA-binding transcription factor activity
LWC06_RS17815	COG1910	domain protein
LWC06_RS17820	COG0725	ABC transporter, periplasmic molybdate-binding protein
LWC06_RS17825	COG4149	molybdate abc transporter
LWC06_RS17830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LWC06_RS17840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LWC06_RS17850	COG3711	transcriptional antiterminator
LWC06_RS17855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LWC06_RS17855	COG2190	(PTS) system
LWC06_RS17855	COG1263	PTS System
LWC06_RS17860	COG1393	Belongs to the ArsC family
LWC06_RS17880	COG1999	signal sequence binding
LWC06_RS17885	COG1349	DNA-binding transcription factor activity
LWC06_RS17895	COG0785	Cytochrome C biogenesis protein
LWC06_RS17900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWC06_RS17905	COG0745	RESPONSE REGULATOR receiver
LWC06_RS17910	COG2205	protein histidine kinase activity
LWC06_RS17920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWC06_RS17925	COG0730	response to heat
LWC06_RS17930	COG0425	Belongs to the sulfur carrier protein TusA family
LWC06_RS17935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWC06_RS17935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWC06_RS17940	COG2210	Belongs to the sulfur carrier protein TusA family
LWC06_RS17945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWC06_RS17945	COG0425	Belongs to the sulfur carrier protein TusA family
LWC06_RS17950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWC06_RS17955	COG2210	Belongs to the sulfur carrier protein TusA family
LWC06_RS17960	COG1937	Protein conserved in bacteria
LWC06_RS17970	COG4536	flavin adenine dinucleotide binding
LWC06_RS17990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LWC06_RS18000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWC06_RS18000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWC06_RS18005	COG0456	acetyltransferase
LWC06_RS18020	COG2719	SpoVR family
LWC06_RS18030	COG2718	Belongs to the UPF0229 family
LWC06_RS18035	COG1960	acyl-CoA dehydrogenase activity
LWC06_RS18040	COG1024	Enoyl-CoA hydratase
LWC06_RS18045	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWC06_RS18050	COG0318	PFAM AMP-dependent synthetase and ligase
LWC06_RS18060	COG2045	Belongs to the ComB family
LWC06_RS18075	COG1309	transcriptional regulator
LWC06_RS18080	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS18085	COG1960	acyl-CoA dehydrogenase activity
LWC06_RS18090	COG2766	serine protein kinase
LWC06_RS18100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LWC06_RS18125	COG0492	ferredoxin-NADP+ reductase activity
LWC06_RS18130	COG1120	ATPase activity
LWC06_RS18135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LWC06_RS18140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWC06_RS18145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWC06_RS18170	COG1595	DNA-templated transcription, initiation
LWC06_RS18200	COG1301	dicarboxylic acid transport
LWC06_RS18205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWC06_RS18210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LWC06_RS18230	COG0517	IMP dehydrogenase activity
LWC06_RS18235	COG1846	Transcriptional regulator
LWC06_RS18245	COG1349	DNA-binding transcription factor activity
LWC06_RS18250	COG1105	Belongs to the carbohydrate kinase PfkB family
LWC06_RS18255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWC06_RS18255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LWC06_RS18255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LWC06_RS18270	COG1827	regulation of RNA biosynthetic process
LWC06_RS18275	COG0157	Belongs to the NadC ModD family
LWC06_RS18300	COG1366	Belongs to the anti-sigma-factor antagonist family
LWC06_RS18310	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS18320	COG0427	acetyl-CoA hydrolase
LWC06_RS18325	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LWC06_RS18330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LWC06_RS18355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LWC06_RS18375	COG0666	response to abiotic stimulus
LWC06_RS18380	COG0402	S-adenosylhomocysteine deaminase activity
LWC06_RS18385	COG0702	epimerase
LWC06_RS18400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWC06_RS18405	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS18410	COG1510	regulation of RNA biosynthetic process
LWC06_RS18420	COG1012	belongs to the aldehyde dehydrogenase family
LWC06_RS18430	COG0326	Molecular chaperone. Has ATPase activity
LWC06_RS18490	COG1396	sequence-specific DNA binding
LWC06_RS18530	COG3773	Cell wall hydrolase
LWC06_RS18540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LWC06_RS18545	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LWC06_RS18615	COG1028	Short-chain dehydrogenase reductase Sdr
LWC06_RS18625	COG1132	(ABC) transporter
LWC06_RS18635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWC06_RS18640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LWC06_RS18645	COG4853	Protein conserved in bacteria
LWC06_RS18650	COG4863	YycH protein
LWC06_RS18655	COG5002	protein histidine kinase activity
LWC06_RS18660	COG0745	RESPONSE REGULATOR receiver
LWC06_RS18665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LWC06_RS18670	COG0305	Participates in initiation and elongation during chromosome replication
LWC06_RS18675	COG0359	binds to the 23S rRNA
LWC06_RS18680	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LWC06_RS18685	COG4241	membrane
LWC06_RS18700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LWC06_RS18705	COG0629	single-stranded DNA binding
LWC06_RS18710	COG0360	Binds together with S18 to 16S ribosomal RNA
LWC06_RS18715	COG0012	GTP binding
LWC06_RS18720	COG4481	Protein conserved in bacteria
LWC06_RS18725	COG0668	transmembrane transport
LWC06_RS18730	COG3949	Membrane
LWC06_RS18745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LWC06_RS18750	COG1475	DNA binding
LWC06_RS18755	COG1192	Involved in chromosome partitioning
LWC06_RS18760	COG1475	DNA binding
LWC06_RS18765	COG0357	Ribosomal RNA small subunit methyltransferase G
LWC06_RS18770	COG0445	tRNA wobble uridine modification
LWC06_RS18775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LWC06_RS18780	COG2234	aminopeptidase activity
LWC06_RS18785	COG1847	R3H domain protein
LWC06_RS18790	COG0706	membrane insertase activity
LWC06_RS18795	COG0594	ribonuclease P activity
LWC06_RS18800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LWC06_RS18840	COG2233	PERMEase