locus-tag	class	description
BME96_RS00010	COG0592	DNA-directed DNA polymerase activity
BME96_RS00020	COG2501	S4 domain
BME96_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BME96_RS00035	COG0187	DNA topoisomerase II activity
BME96_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BME96_RS00045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BME96_RS00055	COG0517	IMP dehydrogenase activity
BME96_RS00055	COG0516	GMP reductase activity
BME96_RS00065	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BME96_RS00070	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BME96_RS00075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BME96_RS00080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BME96_RS00085	COG2011	ABC-type metal ion transport system permease component
BME96_RS00090	COG1464	Belongs to the NlpA lipoprotein family
BME96_RS00105	COG2357	RelA SpoT domain protein
BME96_RS00115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BME96_RS00120	COG1428	Deoxynucleoside kinase
BME96_RS00125	COG1428	Deoxynucleoside kinase
BME96_RS00135	COG1301	dicarboxylic acid transport
BME96_RS00145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BME96_RS00150	COG3425	synthase
BME96_RS00155	COG1017	nitric oxide dioxygenase activity
BME96_RS00155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BME96_RS00160	COG1959	2 iron, 2 sulfur cluster binding
BME96_RS00165	COG0693	protein deglycase activity
BME96_RS00170	COG3858	chitin binding
BME96_RS00170	COG1388	LysM domain
BME96_RS00175	COG1335	isochorismatase
BME96_RS00180	COG0590	tRNA wobble adenosine to inosine editing
BME96_RS00195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BME96_RS00200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BME96_RS00205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BME96_RS00225	COG1982	Orn Lys Arg decarboxylase major
BME96_RS00230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BME96_RS00235	COG3870	Protein conserved in bacteria
BME96_RS00240	COG1728	Protein conserved in bacteria
BME96_RS00245	COG0470	DNA polymerase III
BME96_RS00250	COG1774	PSP1 C-terminal conserved region
BME96_RS00255	COG4467	Involved in initiation control of chromosome replication
BME96_RS00260	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BME96_RS00265	COG2827	Endonuclease containing a URI domain
BME96_RS00270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BME96_RS00280	COG2002	toxin-antitoxin pair type II binding
BME96_RS00290	COG0084	hydrolase, TatD family'
BME96_RS00295	COG3584	3D domain protein
BME96_RS00295	COG3583	domain protein
BME96_RS00305	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BME96_RS00310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BME96_RS00320	COG4466	Protein conserved in bacteria
BME96_RS00330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BME96_RS00335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BME96_RS00340	COG2088	sporulation resulting in formation of a cellular spore
BME96_RS00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BME96_RS00350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BME96_RS00355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BME96_RS00360	COG0193	aminoacyl-tRNA hydrolase activity
BME96_RS00370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BME96_RS00375	COG2002	toxin-antitoxin pair type II binding
BME96_RS00380	COG2244	polysaccharide biosynthetic process
BME96_RS00385	COG3956	TIGRFAM MazG family protein
BME96_RS00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BME96_RS00415	COG1098	S1 RNA binding domain
BME96_RS00425	COG2208	phosphoserine phosphatase activity
BME96_RS00430	COG2304	oxidoreductase activity
BME96_RS00435	COG0515	serine threonine protein kinase
BME96_RS00440	COG0037	tRNA processing
BME96_RS00445	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BME96_RS00450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BME96_RS00455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BME96_RS00460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BME96_RS00470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BME96_RS00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BME96_RS00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BME96_RS00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BME96_RS00490	COG1396	sequence-specific DNA binding
BME96_RS00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BME96_RS00575	COG1285	pathogenesis
BME96_RS00585	COG3880	PFAM UvrB UvrC protein
BME96_RS00590	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BME96_RS00595	COG0542	response to heat
BME96_RS00600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BME96_RS00605	COG4956	integral membrane protein (PIN domain superfamily)
BME96_RS00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BME96_RS00615	COG1045	serine acetyltransferase
BME96_RS00620	COG0215	cysteine-tRNA ligase activity
BME96_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BME96_RS00635	COG3688	RNA-binding protein containing a PIN domain
BME96_RS00645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BME96_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BME96_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
BME96_RS00665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BME96_RS00670	COG0081	regulation of translation
BME96_RS00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BME96_RS00680	COG0222	ribosome binding
BME96_RS00685	COG2813	Specifically methylates the guanine in position
BME96_RS00690	COG0085	RNA polymerase activity
BME96_RS00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BME96_RS00700	COG1358	cellular component organization or biogenesis
BME96_RS00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BME96_RS00710	COG0049	tRNA binding
BME96_RS00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BME96_RS00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BME96_RS00725	COG0051	transcription antitermination factor activity, RNA binding
BME96_RS00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BME96_RS00735	COG0088	Forms part of the polypeptide exit tunnel
BME96_RS00740	COG0089	rRNA binding
BME96_RS00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BME96_RS00750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BME96_RS00755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BME96_RS00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BME96_RS00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BME96_RS00770	COG0255	Belongs to the universal ribosomal protein uL29 family
BME96_RS00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BME96_RS00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BME96_RS00785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BME96_RS00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BME96_RS00795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BME96_RS00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BME96_RS00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BME96_RS00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BME96_RS00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BME96_RS00820	COG1841	ribosomal large subunit assembly
BME96_RS00825	COG0200	Binds to the 23S rRNA
BME96_RS00830	COG0201	protein transport
BME96_RS00835	COG0563	adenylate kinase activity
BME96_RS00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
BME96_RS00845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BME96_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BME96_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BME96_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BME96_RS00865	COG0202	RNA polymerase activity
BME96_RS00870	COG0203	ribosomal protein L17
BME96_RS00875	COG1122	ATPase activity
BME96_RS00880	COG1122	ATPase activity
BME96_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BME96_RS00890	COG0101	tRNA pseudouridine synthase activity
BME96_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BME96_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BME96_RS00975	COG1346	cytolysis
BME96_RS00985	COG0583	DNA-binding transcription factor activity
BME96_RS00990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BME96_RS01010	COG0714	Associated with various cellular activities
BME96_RS01015	COG4548	von Willebrand factor, type A
BME96_RS01035	COG1295	ribonuclease BN
BME96_RS01060	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME96_RS01065	COG0489	protein tyrosine kinase activity
BME96_RS01075	COG2194	sulfuric ester hydrolase activity
BME96_RS01080	COG0726	polysaccharide deacetylase
BME96_RS01140	COG0494	nUDIX hydrolase
BME96_RS01145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BME96_RS01150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BME96_RS01220	COG1595	DNA-templated transcription, initiation
BME96_RS01225	COG5662	AntiSigma factor
BME96_RS01230	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BME96_RS01235	COG4856	YbbR-like protein
BME96_RS01240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BME96_RS01250	COG0745	RESPONSE REGULATOR receiver
BME96_RS01255	COG5002	protein histidine kinase activity
BME96_RS01255	COG3850	Histidine kinase
BME96_RS01260	COG0577	efflux transmembrane transporter activity
BME96_RS01285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BME96_RS01290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BME96_RS01295	COG1801	Protein of unknown function DUF72
BME96_RS01300	COG0488	(ABC) transporter
BME96_RS01320	COG2203	Gaf domain
BME96_RS01320	COG5001	Diguanylate cyclase
BME96_RS01320	COG3706	GGDEF domain
BME96_RS01320	COG4251	negative regulation of phosphorylation
BME96_RS01330	COG1271	oxidase subunit
BME96_RS01335	COG1294	oxidase, subunit
BME96_RS01340	COG4988	ABC transporter
BME96_RS01345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BME96_RS01355	COG1309	transcriptional regulator
BME96_RS01360	COG1131	(ABC) transporter
BME96_RS01385	COG0243	molybdopterin cofactor binding
BME96_RS01415	COG2223	nitrite transmembrane transporter activity
BME96_RS01425	COG2197	response regulator
BME96_RS01435	COG4585	Histidine kinase
BME96_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS01450	COG1114	Component of the transport system for branched-chain amino acids
BME96_RS01455	COG1802	Transcriptional regulator
BME96_RS01460	COG0753	catalase activity
BME96_RS01465	COG0668	transmembrane transport
BME96_RS01480	COG1413	lyase activity
BME96_RS01485	COG1607	acyl-coa hydrolase
BME96_RS01495	COG2124	cytochrome p450
BME96_RS01500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BME96_RS01505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BME96_RS01510	COG0083	homoserine kinase activity
BME96_RS01515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BME96_RS01520	COG0460	homoserine dehydrogenase
BME96_RS01535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BME96_RS01540	COG2814	Major facilitator Superfamily
BME96_RS01545	COG1378	Sugar-specific transcriptional regulator TrmB
BME96_RS01555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BME96_RS01585	COG2855	membrane
BME96_RS01595	COG0789	Transcriptional regulator
BME96_RS01600	COG0352	thiamine-phosphate diphosphorylase activity
BME96_RS01605	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BME96_RS01620	COG1063	alcohol dehydrogenase
BME96_RS01640	COG4145	pantothenate transmembrane transporter activity
BME96_RS01650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BME96_RS01660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BME96_RS01665	COG5506	Protein of unknown function (DUF1694)
BME96_RS01680	COG5577	PFAM Coat F domain
BME96_RS01695	COG0708	Exodeoxyribonuclease III
BME96_RS01700	COG1725	Transcriptional regulator
BME96_RS01705	COG1131	(ABC) transporter
BME96_RS01720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_RS01740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BME96_RS01745	COG0095	Lipoate-protein ligase
BME96_RS01755	COG0159	tryptophan synthase activity
BME96_RS01760	COG0133	tryptophan synthase activity
BME96_RS01765	COG0135	phosphoribosylanthranilate isomerase activity
BME96_RS01770	COG0134	indole-3-glycerol-phosphate synthase activity
BME96_RS01775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BME96_RS01780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BME96_RS01780	COG0512	Glutamine amidotransferase of anthranilate synthase
BME96_RS01785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BME96_RS01790	COG1181	Belongs to the D-alanine--D-alanine ligase family
BME96_RS01795	COG1115	amino acid carrier protein
BME96_RS01800	COG0778	Nitroreductase
BME96_RS01820	COG1418	mRNA catabolic process
BME96_RS01825	COG1876	peptidase activity
BME96_RS01830	COG2814	Major facilitator Superfamily
BME96_RS01835	COG4166	transmembrane transport
BME96_RS01840	COG1970	mechanosensitive ion channel activity
BME96_RS01860	COG0519	Catalyzes the synthesis of GMP from XMP
BME96_RS01865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BME96_RS01870	COG1268	BioY protein
BME96_RS01875	COG0840	transmembrane signaling receptor activity
BME96_RS01890	COG0656	L-ascorbic acid biosynthetic process
BME96_RS01905	COG1304	FMN binding
BME96_RS01910	COG4876	unkown
BME96_RS01915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_RS01920	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BME96_RS01925	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_RS01930	COG4605	iron ion homeostasis
BME96_RS01935	COG4604	ABC transporter, ATP-binding protein
BME96_RS01940	COG4607	ABC-type enterochelin transport system periplasmic component
BME96_RS01945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BME96_RS01950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BME96_RS01955	COG0140	phosphoribosyl-ATP diphosphatase activity
BME96_RS01955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BME96_RS01960	COG0107	imidazoleglycerol-phosphate synthase activity
BME96_RS01965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BME96_RS01970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BME96_RS01975	COG0131	Imidazoleglycerol-phosphate dehydratase
BME96_RS01980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BME96_RS01985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BME96_RS01990	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BME96_RS01995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BME96_RS02000	COG2832	Protein of unknown function (DUF454)
BME96_RS02010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BME96_RS02015	COG1126	abc transporter atp-binding protein
BME96_RS02020	COG0765	amino acid transport
BME96_RS02025	COG0765	amino acid transport
BME96_RS02035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BME96_RS02045	COG0673	inositol 2-dehydrogenase activity
BME96_RS02050	COG1876	peptidase activity
BME96_RS02055	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BME96_RS02060	COG2839	Protein conserved in bacteria
BME96_RS02065	COG0351	phosphomethylpyrimidine kinase
BME96_RS02070	COG1335	isochorismatase
BME96_RS02080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BME96_RS02090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BME96_RS02095	COG0765	amino acid transport
BME96_RS02100	COG1126	abc transporter atp-binding protein
BME96_RS02105	COG0714	Associated with various cellular activities
BME96_RS02110	COG0386	Belongs to the glutathione peroxidase family
BME96_RS02115	COG3949	Membrane
BME96_RS02120	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BME96_RS02120	COG2508	Transcriptional regulator
BME96_RS02125	COG0686	Belongs to the AlaDH PNT family
BME96_RS02130	COG1054	Belongs to the UPF0176 family
BME96_RS02145	COG1278	Cold shock
BME96_RS02150	COG2226	methyltransferase
BME96_RS02150	COG1073	alpha beta
BME96_RS02160	COG2084	Dehydrogenase
BME96_RS02170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BME96_RS02175	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
BME96_RS02180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME96_RS02185	COG0745	RESPONSE REGULATOR receiver
BME96_RS02190	COG3850	Histidine kinase
BME96_RS02190	COG5002	protein histidine kinase activity
BME96_RS02195	COG1217	gtp-binding protein TYPA
BME96_RS02200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BME96_RS02200	COG1263	PTS System
BME96_RS02205	COG0366	Alpha amylase catalytic
BME96_RS02210	COG2188	Transcriptional regulator
BME96_RS02215	COG1834	amidinotransferase
BME96_RS02220	COG3403	YqcI/YcgG family
BME96_RS02225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BME96_RS02230	COG1131	(ABC) transporter
BME96_RS02240	COG2801	Transposase and inactivated derivatives
BME96_RS02250	COG0183	Belongs to the thiolase family
BME96_RS02260	COG2843	Capsule synthesis protein
BME96_RS02270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_RS02280	COG0745	RESPONSE REGULATOR receiver
BME96_RS02285	COG5002	protein histidine kinase activity
BME96_RS02285	COG3850	Histidine kinase
BME96_RS02295	COG1597	lipid kinase activity
BME96_RS02300	COG1846	Transcriptional regulator
BME96_RS02305	COG0702	epimerase
BME96_RS02325	COG1307	EDD domain protein, DegV family
BME96_RS02330	COG0697	spore germination
BME96_RS02335	COG0513	Belongs to the DEAD box helicase family
BME96_RS02340	COG0705	Rhomboid family
BME96_RS02345	COG0736	holo-[acyl-carrier-protein] synthase activity
BME96_RS02350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BME96_RS02350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BME96_RS02355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BME96_RS02360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BME96_RS02370	COG2337	Toxic component of a toxin-antitoxin (TA) module
BME96_RS02375	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_RS02380	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_RS02385	COG2172	sigma factor antagonist activity
BME96_RS02390	COG2208	phosphoserine phosphatase activity
BME96_RS02395	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_RS02400	COG2172	sigma factor antagonist activity
BME96_RS02405	COG1191	sigma factor activity
BME96_RS02410	COG2208	phosphoserine phosphatase activity
BME96_RS02415	COG2183	response to ionizing radiation
BME96_RS02420	COG0753	catalase activity
BME96_RS02425	COG3091	SprT-like family
BME96_RS02515	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BME96_RS02520	COG0802	atpase or kinase
BME96_RS02525	COG1214	PFAM Peptidase M22, glycoprotease
BME96_RS02530	COG0456	acetyltransferase
BME96_RS02535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BME96_RS02540	COG0772	Belongs to the SEDS family
BME96_RS02545	COG0488	(ABC) transporter
BME96_RS02555	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BME96_RS02565	COG1266	CAAX protease self-immunity
BME96_RS02570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BME96_RS02575	COG0459	protein refolding
BME96_RS02580	COG4873	Protein conserved in bacteria
BME96_RS02590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BME96_RS02595	COG0789	Transcriptional regulator
BME96_RS02595	COG4978	Transcriptional regulator
BME96_RS02600	COG0456	acetyltransferase
BME96_RS02605	COG1309	transcriptional regulator
BME96_RS02610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BME96_RS02615	COG0390	transport system, permease component
BME96_RS02620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BME96_RS02625	COG0745	RESPONSE REGULATOR receiver
BME96_RS02630	COG2205	protein histidine kinase activity
BME96_RS02635	COG1136	(ABC) transporter
BME96_RS02640	COG0577	efflux transmembrane transporter activity
BME96_RS02650	COG1309	transcriptional regulator
BME96_RS02660	COG0668	transmembrane transport
BME96_RS02665	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BME96_RS02670	COG0697	spore germination
BME96_RS02675	COG0531	amino acid
BME96_RS02690	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BME96_RS02710	COG3729	General stress protein
BME96_RS02715	COG0714	Associated with various cellular activities
BME96_RS02720	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BME96_RS02725	COG1305	Transglutaminase-like
BME96_RS02730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BME96_RS02730	COG0519	Catalyzes the synthesis of GMP from XMP
BME96_RS02735	COG2252	PERMEase
BME96_RS02745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BME96_RS02750	COG2258	MOSC domain
BME96_RS02760	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BME96_RS02765	COG0519	Catalyzes the synthesis of GMP from XMP
BME96_RS02770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BME96_RS02775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BME96_RS02780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BME96_RS02785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BME96_RS02790	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BME96_RS02795	COG0047	phosphoribosylformylglycinamidine synthase activity
BME96_RS02800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BME96_RS02805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BME96_RS02810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BME96_RS02815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BME96_RS02820	COG0138	bifunctional purine biosynthesis protein purh
BME96_RS02825	COG0151	Belongs to the GarS family
BME96_RS02830	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BME96_RS02835	COG1470	cell adhesion involved in biofilm formation
BME96_RS02840	COG4496	protein, YerC YecD
BME96_RS02845	COG0084	hydrolase, TatD family'
BME96_RS02850	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BME96_RS02855	COG0210	DNA helicase
BME96_RS02860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BME96_RS02865	COG4851	CamS sex pheromone cAM373 precursor
BME96_RS02870	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS02885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BME96_RS02890	COG0154	amidase activity
BME96_RS02895	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BME96_RS02900	COG1597	lipid kinase activity
BME96_RS02905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BME96_RS02910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BME96_RS02915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BME96_RS02925	COG0109	protoheme IX farnesyltransferase activity
BME96_RS02940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BME96_RS02950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME96_RS02960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BME96_RS02960	COG4499	WXG100 protein secretion system (Wss), protein YukC
BME96_RS02970	COG0697	spore germination
BME96_RS02975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BME96_RS02980	COG0109	protoheme IX farnesyltransferase activity
BME96_RS02990	COG0166	Belongs to the GPI family
BME96_RS03000	COG0778	Nitroreductase
BME96_RS03005	COG0564	pseudouridine synthase activity
BME96_RS03015	COG1785	Belongs to the alkaline phosphatase family
BME96_RS03020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_RS03025	COG0488	(ABC) transporter
BME96_RS03055	COG0733	neurotransmitter:sodium symporter activity
BME96_RS03060	COG1757	Na H antiporter
BME96_RS03065	COG0436	Aminotransferase
BME96_RS03070	COG0028	Belongs to the TPP enzyme family
BME96_RS03075	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS03085	COG1414	Transcriptional regulator
BME96_RS03095	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS03105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BME96_RS03110	COG1077	Cell shape determining protein MreB Mrl
BME96_RS03115	COG2340	Cysteine-rich secretory protein family
BME96_RS03120	COG2066	Belongs to the glutaminase family
BME96_RS03125	COG2135	peptidase activity
BME96_RS03130	COG1115	amino acid carrier protein
BME96_RS03140	COG1295	ribonuclease BN
BME96_RS03145	COG2217	Heavy metal translocating P-type atpase
BME96_RS03150	COG0477	Major facilitator Superfamily
BME96_RS03165	COG2056	Na+-H+ antiporter family
BME96_RS03175	COG5001	Diguanylate cyclase
BME96_RS03175	COG3300	MHYT domain
BME96_RS03185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BME96_RS03190	COG0542	response to heat
BME96_RS03195	COG2333	competence protein COMEC
BME96_RS03195	COG0658	competence protein
BME96_RS03205	COG1131	(ABC) transporter
BME96_RS03215	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BME96_RS03220	COG1131	(ABC) transporter
BME96_RS03225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BME96_RS03235	COG2188	Transcriptional regulator
BME96_RS03255	COG1090	epimerase
BME96_RS03260	COG2137	regulation of response to DNA damage stimulus
BME96_RS03265	COG0300	oxidoreductase activity
BME96_RS03275	COG1988	membrane-bound metal-dependent
BME96_RS03280	COG1194	a g-specific adenine glycosylase
BME96_RS03290	COG3557	Belongs to the UPF0374 family
BME96_RS03295	COG1132	(ABC) transporter
BME96_RS03300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BME96_RS03310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BME96_RS03315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BME96_RS03320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME96_RS03325	COG0735	belongs to the Fur family
BME96_RS03335	COG0512	Glutamine amidotransferase of anthranilate synthase
BME96_RS03445	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BME96_RS03465	COG0424	maF-like protein
BME96_RS03475	COG1733	regulation of RNA biosynthetic process
BME96_RS03485	COG0431	NADPH-dependent FMN reductase
BME96_RS03490	COG2986	histidine ammonia-lyase
BME96_RS03495	COG2364	Membrane
BME96_RS03505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME96_RS03515	COG1227	inorganic diphosphatase activity
BME96_RS03540	COG4474	Belongs to the UPF0398 family
BME96_RS03570	COG0456	acetyltransferase
BME96_RS03575	COG1794	racemase activity, acting on amino acids and derivatives
BME96_RS03595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BME96_RS03630	COG4842	Belongs to the WXG100 family
BME96_RS03635	COG5417	Belongs to the EsaB family
BME96_RS03640	COG4499	WXG100 protein secretion system (Wss), protein YukC
BME96_RS03645	COG0433	COG0433 Predicted ATPase
BME96_RS03645	COG1674	ftsk spoiiie
BME96_RS03650	COG1511	domain protein
BME96_RS03670	COG5444	nuclease activity
BME96_RS03690	COG5444	nuclease activity
BME96_RS03765	COG2814	Major facilitator Superfamily
BME96_RS03770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BME96_RS03775	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BME96_RS03780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BME96_RS03795	COG4166	transmembrane transport
BME96_RS03800	COG0277	FAD linked oxidase domain protein
BME96_RS03815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BME96_RS03820	COG1011	Hydrolase
BME96_RS03825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BME96_RS03840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BME96_RS03860	COG1714	RDD family
BME96_RS03865	COG2176	DNA-directed DNA polymerase activity
BME96_RS03870	COG0616	signal peptide processing
BME96_RS03875	COG1714	RDD family
BME96_RS03880	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_RS03910	COG2233	PERMEase
BME96_RS03915	COG2814	Major facilitator Superfamily
BME96_RS03920	COG0697	spore germination
BME96_RS03935	COG0604	alcohol dehydrogenase
BME96_RS03945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BME96_RS03945	COG3320	Male sterility
BME96_RS03970	COG2318	DinB family
BME96_RS03980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BME96_RS03985	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BME96_RS03990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BME96_RS03995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BME96_RS04000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BME96_RS04005	COG0823	Involved in the tonB-independent uptake of proteins
BME96_RS04005	COG1506	peptidase
BME96_RS04005	COG4946	Tricorn protease homolog
BME96_RS04010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BME96_RS04020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BME96_RS04035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BME96_RS04040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BME96_RS04055	COG0567	Dehydrogenase, E1 component
BME96_RS04060	COG0508	dehydrogenase complex catalyzes the overall conversion of
BME96_RS04065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BME96_RS04070	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS04075	COG0534	Mate efflux family protein
BME96_RS04080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BME96_RS04100	COG0288	reversible hydration of carbon dioxide
BME96_RS04110	COG1132	(ABC) transporter
BME96_RS04115	COG1132	(ABC) transporter
BME96_RS04120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME96_RS04135	COG1191	sigma factor activity
BME96_RS04155	COG2226	methyltransferase
BME96_RS04160	COG1854	S-ribosylhomocysteine lyase activity
BME96_RS04165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BME96_RS04170	COG0626	cystathionine gamma-synthase activity
BME96_RS04175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BME96_RS04180	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS04195	COG1131	(ABC) transporter
BME96_RS04200	COG0024	Methionine aminopeptidase
BME96_RS04210	COG1757	Na H antiporter
BME96_RS04215	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BME96_RS04225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BME96_RS04235	COG2270	Major facilitator Superfamily
BME96_RS04245	COG0114	fumarate hydratase activity
BME96_RS04255	COG3842	ATPase activity
BME96_RS04260	COG2508	Transcriptional regulator
BME96_RS04265	COG3679	Belongs to the UPF0342 family
BME96_RS04270	COG1024	Enoyl-CoA hydratase
BME96_RS04280	COG4152	abc transporter atp-binding protein
BME96_RS04285	COG1668	transmembrane transport
BME96_RS04290	COG0420	3'-5' exonuclease activity
BME96_RS04295	COG4717	serine-type aminopeptidase activity
BME96_RS04300	COG1510	regulation of RNA biosynthetic process
BME96_RS04305	COG3481	metal-dependent phosphohydrolase, HD sub domain
BME96_RS04315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BME96_RS04335	COG1510	regulation of RNA biosynthetic process
BME96_RS04360	COG4980	gas vesicle protein
BME96_RS04370	COG0537	adenosine 5'-monophosphoramidase activity
BME96_RS04375	COG1131	(ABC) transporter
BME96_RS04380	COG4473	ABC transporter
BME96_RS04385	COG1473	amidohydrolase
BME96_RS04390	COG2193	ferroxidase activity
BME96_RS04400	COG2814	Major facilitator Superfamily
BME96_RS04410	COG4585	Histidine kinase
BME96_RS04415	COG2197	response regulator
BME96_RS04420	COG2801	Transposase and inactivated derivatives
BME96_RS04435	COG2329	Antibiotic biosynthesis monooxygenase
BME96_RS04440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BME96_RS04445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BME96_RS04450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BME96_RS04455	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BME96_RS04460	COG1164	Oligoendopeptidase f
BME96_RS04480	COG1234	tRNA 3'-trailer cleavage
BME96_RS04485	COG0095	Lipoate-protein ligase
BME96_RS04490	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_RS04505	COG0398	Pfam SNARE associated Golgi protein
BME96_RS04515	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BME96_RS04520	COG1074	ATP-dependent DNA helicase activity
BME96_RS04525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BME96_RS04530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME96_RS04575	COG2311	Membrane
BME96_RS04580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BME96_RS04595	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS04605	COG1307	EDD domain protein, DegV family
BME96_RS04610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_RS04630	COG0561	phosphatase activity
BME96_RS04635	COG1073	alpha beta
BME96_RS04640	COG2151	metal-sulfur cluster biosynthetic enzyme
BME96_RS04650	COG0314	molybdopterin synthase activity
BME96_RS04660	COG2151	metal-sulfur cluster biosynthetic enzyme
BME96_RS04690	COG0535	radical SAM domain protein
BME96_RS04695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BME96_RS04720	COG1744	ABC transporter substrate-binding protein PnrA-like
BME96_RS04725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BME96_RS04730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BME96_RS04745	COG0180	Tryptophanyl-tRNA synthetase
BME96_RS04760	COG1388	LysM domain
BME96_RS04770	COG0456	acetyltransferase
BME96_RS04775	COG3258	Cytochrome c
BME96_RS04780	COG1393	Belongs to the ArsC family
BME96_RS04785	COG4862	establishment of competence for transformation
BME96_RS04795	COG1164	Oligoendopeptidase f
BME96_RS04805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BME96_RS04810	COG2346	COG2346, Truncated hemoglobins
BME96_RS04815	COG4116	CYTH
BME96_RS04820	COG2357	RelA SpoT domain protein
BME96_RS04825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BME96_RS04830	COG0564	pseudouridine synthase activity
BME96_RS04835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BME96_RS04840	COG2239	Acts as a magnesium transporter
BME96_RS04870	COG2323	membrane
BME96_RS04875	COG2153	protein acetylation
BME96_RS04880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BME96_RS04885	COG2382	esterase
BME96_RS04890	COG1132	(ABC) transporter
BME96_RS04895	COG1132	(ABC) transporter
BME96_RS04905	COG0753	catalase activity
BME96_RS04940	COG0436	Aminotransferase
BME96_RS04945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BME96_RS04950	COG2011	ABC-type metal ion transport system permease component
BME96_RS04955	COG1464	Belongs to the NlpA lipoprotein family
BME96_RS04985	COG0584	glycerophosphoryl diester phosphodiesterase
BME96_RS05025	COG1360	Flagellar Motor Protein
BME96_RS05040	COG0488	(ABC) transporter
BME96_RS05060	COG0584	glycerophosphoryl diester phosphodiesterase
BME96_RS05065	COG2130	NADP-dependent
BME96_RS05075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_RS05080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_RS05090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BME96_RS05105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BME96_RS05110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BME96_RS05115	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BME96_RS05120	COG0297	glycogen (starch) synthase activity
BME96_RS05125	COG0697	spore germination
BME96_RS05130	COG0814	amino acid
BME96_RS05165	COG0579	oxidoreductase
BME96_RS05225	COG4974	Belongs to the 'phage' integrase family
BME96_RS05250	COG2258	MOSC domain
BME96_RS05270	COG0586	Pfam SNARE associated Golgi protein
BME96_RS05280	COG1714	RDD family
BME96_RS05295	COG0596	Alpha beta hydrolase
BME96_RS05305	COG0456	acetyltransferase
BME96_RS05330	COG1051	belongs to the nudix hydrolase family
BME96_RS05355	COG1064	alcohol dehydrogenase
BME96_RS05360	COG1525	nuclease
BME96_RS05370	COG0662	Cupin 2, conserved barrel domain protein
BME96_RS05380	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BME96_RS05380	COG0456	acetyltransferase
BME96_RS05440	COG1131	(ABC) transporter
BME96_RS05450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BME96_RS05455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_RS05460	COG1120	ATPase activity
BME96_RS05465	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BME96_RS05470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BME96_RS05480	COG1492	cobalamin metabolic process
BME96_RS05485	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BME96_RS05490	COG0588	phosphoglycerate mutase activity
BME96_RS05500	COG2096	Adenosyltransferase
BME96_RS05530	COG1473	amidohydrolase
BME96_RS05555	COG0653	protein targeting
BME96_RS05570	COG0477	Major facilitator Superfamily
BME96_RS05660	COG2267	carboxylic ester hydrolase activity
BME96_RS05680	COG2816	NAD+ diphosphatase activity
BME96_RS05705	COG0596	Alpha beta hydrolase
BME96_RS05760	COG1247	-acetyltransferase
BME96_RS05775	COG3961	Belongs to the TPP enzyme family
BME96_RS05780	COG1846	Transcriptional regulator
BME96_RS05795	COG0346	lactoylglutathione lyase activity
BME96_RS05835	COG4978	Transcriptional regulator
BME96_RS05835	COG0789	Transcriptional regulator
BME96_RS05840	COG1266	CAAX protease self-immunity
BME96_RS05860	COG2226	methyltransferase
BME96_RS05870	COG0024	Methionine aminopeptidase
BME96_RS05900	COG0745	RESPONSE REGULATOR receiver
BME96_RS05915	COG2205	protein histidine kinase activity
BME96_RS05925	COG1983	PspC domain protein
BME96_RS05945	COG2353	YceI-like domain
BME96_RS05955	COG0346	lactoylglutathione lyase activity
BME96_RS05960	COG0346	lactoylglutathione lyase activity
BME96_RS05965	COG1846	Transcriptional regulator
BME96_RS05985	COG0456	acetyltransferase
BME96_RS06035	COG1247	-acetyltransferase
BME96_RS06040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BME96_RS06045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BME96_RS06050	COG2376	Dihydroxyacetone kinase
BME96_RS06055	COG1461	Dihydroxyacetone kinase
BME96_RS06100	COG3279	Response regulator of the LytR AlgR family
BME96_RS06105	COG0110	maltose O-acetyltransferase activity
BME96_RS06110	COG1695	Transcriptional regulator
BME96_RS06120	COG0535	radical SAM domain protein
BME96_RS06135	COG2169	Transcriptional regulator
BME96_RS06140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BME96_RS06145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BME96_RS06155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BME96_RS06180	COG2031	fatty acid transporter
BME96_RS06190	COG0842	Transport permease protein
BME96_RS06190	COG1129	ABC transporter
BME96_RS06245	COG1201	RNA secondary structure unwinding
BME96_RS06250	COG3586	endonuclease activity
BME96_RS06255	COG0494	nUDIX hydrolase
BME96_RS06265	COG1061	Type III restriction enzyme res subunit
BME96_RS06280	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS06305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BME96_RS06410	COG3655	Transcriptional regulator
BME96_RS06415	COG3739	integral membrane protein
BME96_RS06450	COG0406	alpha-ribazole phosphatase activity
BME96_RS06455	COG0842	Transport permease protein
BME96_RS06460	COG1131	(ABC) transporter
BME96_RS06465	COG1619	proteins homologs of microcin C7 resistance protein MccF
BME96_RS06490	COG0488	(ABC) transporter
BME96_RS06505	COG3588	fructose-bisphosphate aldolase
BME96_RS06515	COG0179	Fumarylacetoacetate (FAA) hydrolase
BME96_RS06525	COG4443	Transcriptional Coactivator p15 (PC4)
BME96_RS06565	COG1098	S1 RNA binding domain
BME96_RS06570	COG2112	serine threonine protein kinase
BME96_RS06575	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS06585	COG3844	kynureninase activity
BME96_RS06590	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BME96_RS06600	COG0733	neurotransmitter:sodium symporter activity
BME96_RS06605	COG0745	RESPONSE REGULATOR receiver
BME96_RS06620	COG0501	Belongs to the peptidase M48B family
BME96_RS06645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BME96_RS06650	COG0456	acetyltransferase
BME96_RS06650	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BME96_RS06675	COG0667	Aldo Keto reductase
BME96_RS06685	COG2322	membrane
BME96_RS06690	COG2226	methyltransferase
BME96_RS06700	COG2267	carboxylic ester hydrolase activity
BME96_RS06730	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_RS06740	COG1309	transcriptional regulator
BME96_RS06745	COG2814	Major facilitator Superfamily
BME96_RS06750	COG2217	Heavy metal translocating P-type atpase
BME96_RS06765	COG1196	nuclear chromosome segregation
BME96_RS06765	COG0739	heme binding
BME96_RS06765	COG0741	lytic transglycosylase activity
BME96_RS06770	COG2323	membrane
BME96_RS06780	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BME96_RS06790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_RS06805	COG1063	alcohol dehydrogenase
BME96_RS06815	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BME96_RS06850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BME96_RS06855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BME96_RS06860	COG1368	sulfuric ester hydrolase activity
BME96_RS06865	COG0640	Transcriptional regulator
BME96_RS06870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BME96_RS06875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BME96_RS06885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BME96_RS06910	COG0598	Magnesium transport protein CorA
BME96_RS06920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BME96_RS06920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BME96_RS06925	COG0307	riboflavin synthase, alpha
BME96_RS06930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BME96_RS06930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BME96_RS06935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BME96_RS06960	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BME96_RS06965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BME96_RS06995	COG5002	protein histidine kinase activity
BME96_RS07000	COG0745	RESPONSE REGULATOR receiver
BME96_RS07010	COG2132	Multicopper oxidase
BME96_RS07015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BME96_RS07020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_RS07025	COG0446	pyridine nucleotide-disulphide oxidoreductase
BME96_RS07040	COG1533	DNA photolyase activity
BME96_RS07125	COG3311	Transcriptional regulator
BME96_RS07130	COG0659	secondary active sulfate transmembrane transporter activity
BME96_RS07140	COG4990	cell redox homeostasis
BME96_RS07155	COG2329	Antibiotic biosynthesis monooxygenase
BME96_RS07165	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_RS07165	COG2202	Pas domain
BME96_RS07185	COG1228	amidohydrolase
BME96_RS07190	COG0530	calcium, potassium:sodium antiporter activity
BME96_RS07195	COG2314	TM2 domain
BME96_RS07200	COG1615	UPF0182 protein
BME96_RS07220	COG5504	Zn-dependent protease
BME96_RS07240	COG3104	oligopeptide transport
BME96_RS07270	COG4294	response to UV
BME96_RS07275	COG0517	IMP dehydrogenase activity
BME96_RS07295	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BME96_RS07305	COG2081	HI0933 family
BME96_RS07310	COG2244	polysaccharide biosynthetic process
BME96_RS07315	COG1187	pseudouridine synthase activity
BME96_RS07320	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BME96_RS07330	COG0510	thiamine kinase activity
BME96_RS07340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BME96_RS07345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_RS07355	COG1363	Peptidase, m42
BME96_RS07360	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BME96_RS07370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_RS07375	COG4848	Belongs to the UPF0354 family
BME96_RS07380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BME96_RS07385	COG1674	ftsk spoiiie
BME96_RS07395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BME96_RS07405	COG4980	gas vesicle protein
BME96_RS07410	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BME96_RS07410	COG1605	Chorismate mutase
BME96_RS07430	COG0123	including yeast histone deacetylase and acetoin utilization protein
BME96_RS07435	COG0517	IMP dehydrogenase activity
BME96_RS07440	COG0454	-acetyltransferase
BME96_RS07445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BME96_RS07450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BME96_RS07455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BME96_RS07460	COG2199	diguanylate cyclase activity
BME96_RS07460	COG2203	Gaf domain
BME96_RS07465	COG1956	GAF domain-containing protein
BME96_RS07470	COG1309	transcriptional regulator
BME96_RS07475	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BME96_RS07480	COG1104	cysteine desulfurase activity
BME96_RS07485	COG0301	tRNA thio-modification
BME96_RS07495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BME96_RS07505	COG3874	Sporulation protein YtfJ
BME96_RS07510	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BME96_RS07515	COG0827	DNA restriction-modification system
BME96_RS07520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BME96_RS07525	COG0521	Mo-molybdopterin cofactor biosynthetic process
BME96_RS07530	COG0589	response to stress
BME96_RS07540	COG1842	Phage shock protein A
BME96_RS07555	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BME96_RS07560	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BME96_RS07580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BME96_RS07590	COG1459	type II secretion system
BME96_RS07600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BME96_RS07625	COG4109	DRTGG domain
BME96_RS07635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BME96_RS07655	COG0587	DNA-directed DNA polymerase activity
BME96_RS07660	COG0281	malic enzyme
BME96_RS07665	COG2186	Transcriptional regulator
BME96_RS07670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BME96_RS07675	COG0825	malonyl-CoA metabolic process
BME96_RS07680	COG0205	6-phosphofructokinase activity
BME96_RS07690	COG3030	protein affecting phage T7 exclusion by the F plasmid
BME96_RS07695	COG0628	permease
BME96_RS07700	COG0372	Belongs to the citrate synthase family
BME96_RS07705	COG0538	isocitrate dehydrogenase activity
BME96_RS07710	COG0039	L-malate dehydrogenase activity
BME96_RS07720	COG0745	RESPONSE REGULATOR receiver
BME96_RS07725	COG5002	protein histidine kinase activity
BME96_RS07730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BME96_RS07730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BME96_RS07735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BME96_RS07740	COG0237	dephospho-CoA kinase activity
BME96_RS07745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BME96_RS07750	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BME96_RS07760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BME96_RS07765	COG3611	Membrane attachment protein
BME96_RS07770	COG1484	DNA-dependent DNA replication
BME96_RS07780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BME96_RS07785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BME96_RS07790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BME96_RS07795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BME96_RS07800	COG3326	Membrane
BME96_RS07805	COG0398	Pfam SNARE associated Golgi protein
BME96_RS07820	COG1363	Peptidase, m42
BME96_RS07825	COG0741	lytic transglycosylase activity
BME96_RS07830	COG1131	(ABC) transporter
BME96_RS07855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BME96_RS07860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BME96_RS07865	COG0072	phenylalanine-tRNA ligase activity
BME96_RS07865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BME96_RS07870	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BME96_RS07875	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BME96_RS07880	COG1286	toxin biosynthetic process
BME96_RS07885	COG1796	DNA polymerase
BME96_RS07885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BME96_RS07890	COG1193	negative regulation of DNA recombination
BME96_RS07895	COG3766	membrane
BME96_RS07900	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_RS07905	COG1309	transcriptional regulator
BME96_RS07910	COG1024	Enoyl-CoA hydratase
BME96_RS07915	COG2086	electron transfer activity
BME96_RS07920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BME96_RS07925	COG3118	belongs to the thioredoxin family
BME96_RS07930	COG0322	excinuclease ABC activity
BME96_RS07935	COG1719	4-vinyl reductase, 4VR
BME96_RS07940	COG2009	succinate dehydrogenase
BME96_RS07945	COG1053	succinate dehydrogenase
BME96_RS07950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BME96_RS07955	COG0824	Thioesterase
BME96_RS07960	COG2197	response regulator
BME96_RS07965	COG1846	Transcriptional regulator
BME96_RS07970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BME96_RS07975	COG5401	PFAM Sporulation and spore germination
BME96_RS07980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BME96_RS07985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BME96_RS07990	COG0622	Phosphoesterase
BME96_RS08015	COG0544	peptidyl-prolyl cis-trans isomerase activity
BME96_RS08020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BME96_RS08030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BME96_RS08035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BME96_RS08040	COG0765	amino acid transport
BME96_RS08055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BME96_RS08060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BME96_RS08065	COG0181	hydroxymethylbilane synthase activity
BME96_RS08080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BME96_RS08085	COG1388	LysM domain
BME96_RS08085	COG1388	LysM domain
BME96_RS08100	COG0525	valine-tRNA ligase activity
BME96_RS08110	COG0189	ligase activity
BME96_RS08115	COG0285	dihydrofolate synthase activity
BME96_RS08125	COG2003	Belongs to the UPF0758 family
BME96_RS08160	COG1077	Cell shape determining protein MreB Mrl
BME96_RS08175	COG0850	regulation of cytokinetic process
BME96_RS08180	COG2894	cell division
BME96_RS08190	COG1994	Peptidase M50
BME96_RS08195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BME96_RS08200	COG2868	ribosomal protein
BME96_RS08215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BME96_RS08220	COG0077	Prephenate dehydratase
BME96_RS08225	COG1388	LysM domain
BME96_RS08235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BME96_RS08245	COG0217	transcriptional regulatory protein
BME96_RS08250	COG0632	four-way junction helicase activity
BME96_RS08255	COG2255	four-way junction helicase activity
BME96_RS08265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BME96_RS08270	COG0343	queuine tRNA-ribosyltransferase activity
BME96_RS08275	COG1862	Preprotein translocase
BME96_RS08285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BME96_RS08295	COG2244	polysaccharide biosynthetic process
BME96_RS08305	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BME96_RS08305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BME96_RS08310	COG5416	Lipopolysaccharide assembly protein A domain
BME96_RS08315	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BME96_RS08315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BME96_RS08320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BME96_RS08325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BME96_RS08330	COG1490	D-aminoacyl-tRNA deacylase activity
BME96_RS08335	COG4991	sh3 domain protein
BME96_RS08335	COG3103	Sh3 type 3 domain protein
BME96_RS08335	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME96_RS08340	COG0124	histidyl-tRNA synthetase
BME96_RS08345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BME96_RS08360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BME96_RS08365	COG1959	2 iron, 2 sulfur cluster binding
BME96_RS08370	COG1104	cysteine desulfurase activity
BME96_RS08375	COG0482	sulfurtransferase activity
BME96_RS08385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BME96_RS08395	COG0628	permease
BME96_RS08400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BME96_RS08405	COG4472	Bacterial protein of unknown function (DUF965)
BME96_RS08410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BME96_RS08415	COG3906	Belongs to the UPF0473 family
BME96_RS08420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BME96_RS08425	COG4122	O-methyltransferase activity
BME96_RS08430	COG0572	uridine kinase
BME96_RS08435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BME96_RS08445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BME96_RS08460	COG1320	monovalent cation:proton antiporter activity
BME96_RS08465	COG2212	antiporter activity
BME96_RS08470	COG1863	multisubunit Na H antiporter MnhE subunit
BME96_RS08475	COG0651	ATP synthesis coupled electron transport
BME96_RS08480	COG1006	Multisubunit Na H antiporter MnhC subunit
BME96_RS08485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BME96_RS08485	COG2111	Na H antiporter
BME96_RS08495	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BME96_RS08500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BME96_RS08505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BME96_RS08510	COG1534	Rna-binding protein
BME96_RS08515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BME96_RS08520	COG1713	HD superfamily hydrolase involved in NAD metabolism
BME96_RS08525	COG0799	negative regulation of ribosome biogenesis
BME96_RS08530	COG2226	methyltransferase
BME96_RS08535	COG1596	polysaccharide export
BME96_RS08535	COG1555	photosystem II stabilization
BME96_RS08540	COG2131	deaminase
BME96_RS08545	COG2333	competence protein COMEC
BME96_RS08545	COG0658	competence protein
BME96_RS08555	COG1466	dna polymerase III delta subunit
BME96_RS08560	COG0268	Binds directly to 16S ribosomal RNA
BME96_RS08565	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BME96_RS08570	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME96_RS08580	COG0481	GTPase activity
BME96_RS08585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BME96_RS08590	COG1420	regulation of RNA biosynthetic process
BME96_RS08595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BME96_RS08600	COG0443	Heat shock 70 kDa protein
BME96_RS08605	COG0484	heat shock protein binding
BME96_RS08610	COG2264	protein methyltransferase activity
BME96_RS08615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BME96_RS08620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BME96_RS08625	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BME96_RS08630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BME96_RS08635	COG1610	YqeY-like protein
BME96_RS08640	COG1030	water channel activity
BME96_RS08645	COG4864	UPF0365 protein
BME96_RS08665	COG1702	phosphate starvation-inducible protein PhoH
BME96_RS08670	COG1480	7TM receptor with intracellular HD hydrolase
BME96_RS08675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BME96_RS08685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BME96_RS08695	COG1381	Involved in DNA repair and RecF pathway recombination
BME96_RS08700	COG0752	glycyl-tRNA synthetase alpha subunit
BME96_RS08705	COG0751	glycine-tRNA ligase activity
BME96_RS08710	COG0517	IMP dehydrogenase activity
BME96_RS08715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BME96_RS08720	COG0358	DNA primase activity
BME96_RS08725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BME96_RS08740	COG2384	SAM-dependent methyltransferase
BME96_RS08745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BME96_RS08755	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BME96_RS08765	COG4709	membrane
BME96_RS08780	COG0704	Plays a role in the regulation of phosphate uptake
BME96_RS08815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BME96_RS08820	COG0477	Major facilitator Superfamily
BME96_RS08825	COG0768	penicillin binding
BME96_RS08840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BME96_RS08845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BME96_RS08850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BME96_RS08860	COG0705	Rhomboid family
BME96_RS08860	COG0457	Tetratricopeptide repeat
BME96_RS08870	COG0697	spore germination
BME96_RS08880	COG1940	carbohydrate kinase activity
BME96_RS08890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_RS08925	COG4537	Required for transformation and DNA binding
BME96_RS08935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BME96_RS09000	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BME96_RS09025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BME96_RS09030	COG0582	viral genome integration into host DNA
BME96_RS09070	COG0740	serine-type endopeptidase activity
BME96_RS09155	COG1876	peptidase activity
BME96_RS09190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BME96_RS09205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BME96_RS09210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BME96_RS09215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BME96_RS09220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BME96_RS09225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_RS09230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BME96_RS09235	COG1321	iron dependent repressor
BME96_RS09240	COG1752	Esterase of the alpha-beta hydrolase superfamily
BME96_RS09255	COG0006	proline dipeptidase activity
BME96_RS09260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BME96_RS09265	COG3854	ATPases associated with a variety of cellular activities
BME96_RS09305	COG0511	ligase activity, forming carbon-carbon bonds
BME96_RS09310	COG0439	Biotin carboxylase
BME96_RS09315	COG1302	Protein conserved in bacteria
BME96_RS09320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BME96_RS09325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BME96_RS09330	COG1570	exodeoxyribonuclease VII activity
BME96_RS09335	COG1722	exodeoxyribonuclease VII activity
BME96_RS09350	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BME96_RS09355	COG1438	arginine binding
BME96_RS09360	COG0497	DNA recombination
BME96_RS09365	COG0750	zinc metalloprotease
BME96_RS09370	COG0745	RESPONSE REGULATOR receiver
BME96_RS09375	COG0527	aspartate kinase activity
BME96_RS09385	COG3290	protein histidine kinase activity
BME96_RS09385	COG3829	transcription factor binding
BME96_RS09390	COG0280	phosphate acetyltransferase
BME96_RS09400	COG3426	butyrate kinase activity
BME96_RS09405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BME96_RS09410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BME96_RS09415	COG0022	dehydrogenase e1 component
BME96_RS09420	COG0508	dehydrogenase complex catalyzes the overall conversion of
BME96_RS09430	COG4129	membrane
BME96_RS09435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BME96_RS09435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BME96_RS09440	COG0346	lactoylglutathione lyase activity
BME96_RS09445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BME96_RS09450	COG2195	Cleaves the N-terminal amino acid of tripeptides
BME96_RS09460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BME96_RS09465	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS09470	COG1234	tRNA 3'-trailer cleavage
BME96_RS09475	COG1902	pentaerythritol trinitrate reductase activity
BME96_RS09480	COG0584	glycerophosphoryl diester phosphodiesterase
BME96_RS09485	COG4187	Peptidase family M20/M25/M40
BME96_RS09490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_RS09495	COG0300	oxidoreductase activity
BME96_RS09505	COG0667	Aldo Keto reductase
BME96_RS09515	COG1379	DNA repair
BME96_RS09520	COG1300	Membrane
BME96_RS09525	COG0735	belongs to the Fur family
BME96_RS09535	COG4974	Belongs to the 'phage' integrase family
BME96_RS09540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BME96_RS09555	COG1686	Belongs to the peptidase S11 family
BME96_RS09560	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_RS09565	COG2172	sigma factor antagonist activity
BME96_RS09585	COG0697	spore germination
BME96_RS09590	COG0019	diaminopimelate decarboxylase activity
BME96_RS09595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BME96_RS09605	COG0456	acetyltransferase
BME96_RS09615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BME96_RS09620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BME96_RS09625	COG1686	Belongs to the peptidase S11 family
BME96_RS09630	COG2715	membrane protein required for spore maturation
BME96_RS09635	COG0700	Nucleoside recognition
BME96_RS09640	COG1187	pseudouridine synthase activity
BME96_RS09645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_RS09650	COG1333	cytochrome c biogenesis protein
BME96_RS09655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BME96_RS09660	COG0745	RESPONSE REGULATOR receiver
BME96_RS09665	COG5002	protein histidine kinase activity
BME96_RS09675	COG1141	Ferredoxin
BME96_RS09680	COG4955	Helix-turn-helix domain
BME96_RS09685	COG0514	ATP-dependent DNA helicase (RecQ)
BME96_RS09690	COG1266	CAAX protease self-immunity
BME96_RS09700	COG1408	metallophosphoesterase
BME96_RS09705	COG4862	establishment of competence for transformation
BME96_RS09710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BME96_RS09715	COG0492	ferredoxin-NADP+ reductase activity
BME96_RS09720	COG0252	asparaginase activity
BME96_RS09725	COG2339	peptidase activity
BME96_RS09730	COG3409	Peptidoglycan-binding domain 1 protein
BME96_RS09730	COG3773	Cell wall hydrolase
BME96_RS09735	COG2959	enzyme of heme biosynthesis
BME96_RS09745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BME96_RS09755	COG0539	negative regulation of cytoplasmic translation
BME96_RS09775	COG1160	GTP binding
BME96_RS09780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BME96_RS09800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BME96_RS09805	COG0776	regulation of translation
BME96_RS09815	COG0142	geranyltranstransferase activity
BME96_RS09820	COG2226	methyltransferase
BME96_RS09825	COG0142	geranyltranstransferase activity
BME96_RS09830	COG0105	UTP biosynthetic process
BME96_RS09835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BME96_RS09840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BME96_RS09845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BME96_RS09850	COG4401	Chorismate mutase type I
BME96_RS09855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BME96_RS09860	COG0287	Prephenate dehydrogenase
BME96_RS09865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BME96_RS09870	COG0457	Tetratricopeptide repeat
BME96_RS09875	COG5582	Belongs to the UPF0302 family
BME96_RS09885	COG0723	plastoquinol--plastocyanin reductase activity
BME96_RS09890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BME96_RS09900	COG4347	Protein of unknown function (DUF1405)
BME96_RS09910	COG2738	Putative neutral zinc metallopeptidase
BME96_RS09915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_RS09920	COG1694	Mazg nucleotide pyrophosphohydrolase
BME96_RS09925	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BME96_RS09930	COG1803	Methylglyoxal synthase
BME96_RS09935	COG0438	transferase activity, transferring glycosyl groups
BME96_RS09940	COG0617	tRNA 3'-terminal CCA addition
BME96_RS09955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BME96_RS09960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BME96_RS09965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BME96_RS09965	COG1199	ATP-dependent helicase activity
BME96_RS09980	COG0436	Aminotransferase
BME96_RS09985	COG0017	Asparaginyl-tRNA synthetase
BME96_RS09990	COG3935	DnaD domain protein
BME96_RS09995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BME96_RS10000	COG4499	WXG100 protein secretion system (Wss), protein YukC
BME96_RS10000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BME96_RS10005	COG3331	DNA recombination
BME96_RS10025	COG0295	cytidine deaminase activity
BME96_RS10030	COG3599	regulation of cell shape
BME96_RS10040	COG0116	Belongs to the methyltransferase superfamily
BME96_RS10045	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BME96_RS10050	COG3424	synthase
BME96_RS10055	COG1755	Isoprenylcysteine carboxyl methyltransferase
BME96_RS10060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME96_RS10065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BME96_RS10080	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BME96_RS10095	COG1418	mRNA catabolic process
BME96_RS10100	COG0791	NLP P60 protein
BME96_RS10100	COG1388	LysM domain
BME96_RS10105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BME96_RS10110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BME96_RS10115	COG0746	molybdenum cofactor guanylyltransferase activity
BME96_RS10120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BME96_RS10125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BME96_RS10130	COG0805	protein transport
BME96_RS10135	COG4479	Belongs to the UPF0346 family
BME96_RS10150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BME96_RS10150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BME96_RS10170	COG1254	Belongs to the acylphosphatase family
BME96_RS10190	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BME96_RS10195	COG1140	nitrate reductase beta subunit
BME96_RS10205	COG2181	nitrate reductase activity
BME96_RS10210	COG0723	plastoquinol--plastocyanin reductase activity
BME96_RS10210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME96_RS10220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BME96_RS10225	COG0723	plastoquinol--plastocyanin reductase activity
BME96_RS10225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME96_RS10230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BME96_RS10235	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BME96_RS10240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BME96_RS10245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BME96_RS10250	COG1024	Enoyl-CoA hydratase
BME96_RS10255	COG0511	ligase activity, forming carbon-carbon bonds
BME96_RS10260	COG0439	Biotin carboxylase
BME96_RS10265	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_RS10270	COG1960	acyl-CoA dehydrogenase activity
BME96_RS10275	COG1309	transcriptional regulator
BME96_RS10280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BME96_RS10285	COG0187	DNA topoisomerase II activity
BME96_RS10290	COG1832	CoA-binding protein
BME96_RS10295	COG1174	glycine betaine transport
BME96_RS10305	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BME96_RS10310	COG1469	GTP cyclohydrolase I activity
BME96_RS10315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BME96_RS10325	COG0824	Thioesterase
BME96_RS10340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_RS10345	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BME96_RS10350	COG4191	Histidine kinase
BME96_RS10360	COG4846	Membrane protein involved in cytochrome C biogenesis
BME96_RS10365	COG2201	protein-glutamate methylesterase activity
BME96_RS10370	COG2111	Na H antiporter
BME96_RS10375	COG0785	Cytochrome C biogenesis protein
BME96_RS10380	COG3763	UPF0154 protein
BME96_RS10395	COG4224	UPF0291 protein
BME96_RS10400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BME96_RS10405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BME96_RS10410	COG0174	glutamine synthetase
BME96_RS10415	COG0789	Transcriptional regulator
BME96_RS10420	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BME96_RS10425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BME96_RS10430	COG0464	growth
BME96_RS10435	COG1923	regulation of RNA biosynthetic process
BME96_RS10440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BME96_RS10445	COG0783	Belongs to the Dps family
BME96_RS10450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BME96_RS10455	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BME96_RS10475	COG4550	Control of competence regulator ComK, YlbF/YmcA
BME96_RS10480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BME96_RS10485	COG2359	stage V sporulation protein S
BME96_RS10490	COG1692	metallophosphoesterase
BME96_RS10495	COG1418	mRNA catabolic process
BME96_RS10500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BME96_RS10505	COG1058	Belongs to the CinA family
BME96_RS10505	COG1546	Belongs to the CinA family
BME96_RS10510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BME96_RS10515	COG1426	Protein conserved in bacteria
BME96_RS10530	COG0300	oxidoreductase activity
BME96_RS10535	COG0612	Peptidase, M16
BME96_RS10540	COG0612	Peptidase, M16
BME96_RS10545	COG1079	Belongs to the binding-protein-dependent transport system permease family
BME96_RS10550	COG4603	Belongs to the binding-protein-dependent transport system permease family
BME96_RS10555	COG3845	ABC transporter
BME96_RS10560	COG1744	ABC transporter substrate-binding protein PnrA-like
BME96_RS10565	COG2188	Transcriptional regulator
BME96_RS10570	COG1674	ftsk spoiiie
BME96_RS10580	COG0740	serine-type endopeptidase activity
BME96_RS10585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BME96_RS10590	COG0527	aspartate kinase activity
BME96_RS10595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BME96_RS10600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BME96_RS10605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME96_RS10610	COG1873	PFAM PRC-barrel domain
BME96_RS10615	COG0612	Peptidase, M16
BME96_RS10620	COG0726	polysaccharide deacetylase
BME96_RS10625	COG1185	polyribonucleotide nucleotidyltransferase activity
BME96_RS10630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BME96_RS10635	COG0196	riboflavin kinase activity
BME96_RS10640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BME96_RS10645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BME96_RS10655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BME96_RS10660	COG1358	cellular component organization or biogenesis
BME96_RS10665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BME96_RS10670	COG0195	Participates in both transcription termination and antitermination
BME96_RS10675	COG0779	Required for maturation of 30S ribosomal subunits
BME96_RS10680	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_RS10685	COG2176	DNA-directed DNA polymerase activity
BME96_RS10690	COG0750	zinc metalloprotease
BME96_RS10695	COG4589	Belongs to the CDS family
BME96_RS10700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BME96_RS10705	COG0233	cytoplasmic translational termination
BME96_RS10710	COG0528	UMP kinase activity
BME96_RS10715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BME96_RS10720	COG0052	Belongs to the universal ribosomal protein uS2 family
BME96_RS10735	COG1191	sigma factor activity
BME96_RS10740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BME96_RS10745	COG1776	CheC inhibitor of MCP methylation
BME96_RS10750	COG0835	chemotaxis
BME96_RS10755	COG2201	protein-glutamate methylesterase activity
BME96_RS10760	COG0455	bacterial-type flagellum organization
BME96_RS10765	COG1419	protein localization to endoplasmic reticulum
BME96_RS10770	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BME96_RS10775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BME96_RS10780	COG1684	flagellar biosynthetic protein fliR
BME96_RS10785	COG1987	bacterial-type flagellum assembly
BME96_RS10790	COG1338	Plays a role in the flagellum-specific transport system
BME96_RS10795	COG3190	flagellar
BME96_RS10800	COG2201	protein-glutamate methylesterase activity
BME96_RS10805	COG1776	CheC inhibitor of MCP methylation
BME96_RS10805	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BME96_RS10810	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BME96_RS10815	COG1580	Controls the rotational direction of flagella during chemotaxis
BME96_RS10820	COG1582	Flagellar protein (FlbD)
BME96_RS10825	COG4786	Flagellar basal body rod
BME96_RS10835	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BME96_RS10855	COG1157	protein secretion by the type III secretion system
BME96_RS10865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BME96_RS10870	COG1766	The M ring may be actively involved in energy transduction
BME96_RS10875	COG1677	Flagellar hook-basal body complex protein FliE
BME96_RS10880	COG1558	bacterial-type flagellum-dependent cell motility
BME96_RS10885	COG1815	bacterial-type flagellum-dependent cell motility
BME96_RS10890	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BME96_RS10895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BME96_RS10900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BME96_RS10905	COG4974	Belongs to the 'phage' integrase family
BME96_RS10920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BME96_RS10925	COG0758	DNA mediated transformation
BME96_RS10930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BME96_RS10935	COG0045	succinate-CoA ligase (ADP-forming) activity
BME96_RS10940	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BME96_RS10950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BME96_RS10955	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BME96_RS10965	COG0335	large ribosomal subunit rRNA binding
BME96_RS10970	COG0336	Belongs to the RNA methyltransferase TrmD family
BME96_RS10975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BME96_RS10985	COG1837	Belongs to the UPF0109 family
BME96_RS10990	COG0228	four-way junction DNA binding
BME96_RS10995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BME96_RS11000	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BME96_RS11005	COG0552	protein localization to endoplasmic reticulum
BME96_RS11010	COG1196	nuclear chromosome segregation
BME96_RS11015	COG4840	Belongs to the UPF0435 family
BME96_RS11020	COG0571	ribonuclease III activity
BME96_RS11025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BME96_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS11035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BME96_RS11040	COG0416	fatty acid biosynthetic process
BME96_RS11045	COG1349	DNA-binding transcription factor activity
BME96_RS11050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BME96_RS11055	COG1760	l-serine dehydratase
BME96_RS11060	COG1760	l-serine dehydratase
BME96_RS11070	COG1461	Dihydroxyacetone kinase
BME96_RS11075	COG1302	Protein conserved in bacteria
BME96_RS11080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BME96_RS11090	COG1564	THIamine pyrophosphokinase
BME96_RS11095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BME96_RS11100	COG1162	GTPase activity
BME96_RS11105	COG2815	serine threonine protein kinase
BME96_RS11105	COG0515	serine threonine protein kinase
BME96_RS11110	COG0631	protein serine/threonine phosphatase activity
BME96_RS11115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BME96_RS11115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BME96_RS11120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BME96_RS11125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BME96_RS11130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BME96_RS11135	COG1758	RNA polymerase activity
BME96_RS11140	COG0194	GDP metabolic process
BME96_RS11145	COG2052	Domain of unknown function (DUF370)
BME96_RS11150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BME96_RS11160	COG1764	response to oxidative stress
BME96_RS11165	COG0583	DNA-binding transcription factor activity
BME96_RS11170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BME96_RS11175	COG0284	orotidine-5'-phosphate decarboxylase activity
BME96_RS11180	COG0167	dihydroorotate dehydrogenase activity
BME96_RS11185	COG0543	2 iron, 2 sulfur cluster binding
BME96_RS11190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BME96_RS11195	COG0505	Belongs to the CarA family
BME96_RS11200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BME96_RS11205	COG0540	Belongs to the ATCase OTCase family
BME96_RS11210	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BME96_RS11215	COG0564	pseudouridine synthase activity
BME96_RS11220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BME96_RS11230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BME96_RS11235	COG3599	regulation of cell shape
BME96_RS11240	COG2302	S4 RNA-binding domain
BME96_RS11245	COG0762	integral membrane protein
BME96_RS11250	COG1799	cell septum assembly
BME96_RS11255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BME96_RS11260	COG1496	oxidoreductase activity
BME96_RS11265	COG1873	PFAM PRC-barrel domain
BME96_RS11270	COG1191	sigma factor activity
BME96_RS11275	COG1191	sigma factor activity
BME96_RS11285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BME96_RS11290	COG0849	cell division
BME96_RS11295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BME96_RS11300	COG0772	Belongs to the SEDS family
BME96_RS11305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BME96_RS11310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BME96_RS11315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BME96_RS11320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BME96_RS11325	COG0768	penicillin binding
BME96_RS11330	COG0768	penicillin binding
BME96_RS11335	COG4839	cell division protein FtsL
BME96_RS11340	COG0275	rRNA processing
BME96_RS11345	COG2001	Belongs to the MraZ family
BME96_RS11350	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BME96_RS11360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BME96_RS11365	COG0454	-acetyltransferase
BME96_RS11375	COG1024	Enoyl-CoA hydratase
BME96_RS11380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BME96_RS11385	COG1399	metal-binding, possibly nucleic acid-binding protein
BME96_RS11390	COG1323	Belongs to the UPF0348 family
BME96_RS11395	COG3480	Lon protease (S16) C-terminal proteolytic domain
BME96_RS11400	COG3314	Sporulation integral membrane protein YlbJ
BME96_RS11405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BME96_RS11410	COG0742	ribosomal rna small subunit methyltransferase
BME96_RS11415	COG4471	UPF0298 protein
BME96_RS11420	COG3679	Belongs to the UPF0342 family
BME96_RS11435	COG2340	Cysteine-rich secretory protein family
BME96_RS11450	COG2322	membrane
BME96_RS11455	COG3336	cytochrome c oxidase
BME96_RS11465	COG1845	cytochrome c oxidase, subunit III
BME96_RS11470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME96_RS11480	COG0109	protoheme IX farnesyltransferase activity
BME96_RS11485	COG1612	heme a metabolic process
BME96_RS11490	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BME96_RS11495	COG0772	Belongs to the SEDS family
BME96_RS11500	COG4838	Belongs to the UPF0358 family
BME96_RS11505	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BME96_RS11520	COG4896	Protein conserved in bacteria
BME96_RS11530	COG0483	inositol monophosphate 1-phosphatase activity
BME96_RS11540	COG4493	Belongs to the UPF0637 family
BME96_RS11545	COG4476	Belongs to the UPF0223 family
BME96_RS11555	COG1982	Orn Lys Arg decarboxylase major
BME96_RS11585	COG0022	dehydrogenase e1 component
BME96_RS11595	COG0497	DNA recombination
BME96_RS11600	COG0242	peptide deformylase activity
BME96_RS11605	COG0561	phosphatase activity
BME96_RS11610	COG5503	Protein of unknown function (DUF1447)
BME96_RS11615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BME96_RS11620	COG0028	Belongs to the TPP enzyme family
BME96_RS11625	COG0569	domain protein
BME96_RS11630	COG1132	(ABC) transporter
BME96_RS11635	COG1132	(ABC) transporter
BME96_RS11640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_RS11645	COG0450	alkyl hydroperoxide reductase
BME96_RS11655	COG1473	amidohydrolase
BME96_RS11660	COG2171	N-acyltransferase activity
BME96_RS11665	COG0517	IMP dehydrogenase activity
BME96_RS11670	COG0640	Transcriptional regulator
BME96_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS11685	COG1408	metallophosphoesterase
BME96_RS11705	COG0697	spore germination
BME96_RS11710	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BME96_RS11720	COG0436	Aminotransferase
BME96_RS11730	COG0681	Belongs to the peptidase S26 family
BME96_RS11740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME96_RS11750	COG3835	regulator
BME96_RS11765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BME96_RS11770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BME96_RS11780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BME96_RS11785	COG0303	'Molybdopterin
BME96_RS11810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BME96_RS11825	COG2323	membrane
BME96_RS11830	COG1301	dicarboxylic acid transport
BME96_RS11835	COG0604	alcohol dehydrogenase
BME96_RS11840	COG0003	Pfam Anion-transporting ATPase
BME96_RS11850	COG1966	Carbon starvation protein
BME96_RS11855	COG2427	Protein of unknown function (DUF1641)
BME96_RS11860	COG3383	formate dehydrogenase (NAD+) activity
BME96_RS11865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BME96_RS11870	COG3069	C4-dicarboxylate transmembrane transporter activity
BME96_RS11880	COG3859	Proton-coupled thiamine transporter YuaJ
BME96_RS11885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BME96_RS11905	COG2720	vancomycin resistance protein
BME96_RS11915	COG1252	NADH dehydrogenase
BME96_RS11930	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_RS12015	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BME96_RS12025	COG2027	D-alanyl-D-alanine carboxypeptidase
BME96_RS12035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BME96_RS12040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BME96_RS12050	COG1917	Cupin 2, conserved barrel domain protein
BME96_RS12055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BME96_RS12070	COG1174	glycine betaine transport
BME96_RS12075	COG1732	Glycine betaine
BME96_RS12080	COG1174	glycine betaine transport
BME96_RS12090	COG1510	regulation of RNA biosynthetic process
BME96_RS12100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME96_RS12110	COG0402	S-adenosylhomocysteine deaminase activity
BME96_RS12115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BME96_RS12120	COG0477	Major facilitator Superfamily
BME96_RS12130	COG1960	acyl-CoA dehydrogenase activity
BME96_RS12135	COG1960	acyl-CoA dehydrogenase activity
BME96_RS12155	COG2030	dehydratase
BME96_RS12190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_RS12200	COG0495	leucyl-tRNA aminoacylation
BME96_RS12205	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BME96_RS12210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BME96_RS12215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BME96_RS12220	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BME96_RS12225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BME96_RS12230	COG1116	anion transmembrane transporter activity
BME96_RS12235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BME96_RS12240	COG0494	nUDIX hydrolase
BME96_RS12255	COG1120	ATPase activity
BME96_RS12260	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_RS12265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BME96_RS12270	COG0596	Alpha beta hydrolase
BME96_RS12275	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BME96_RS12280	COG1169	isochorismate synthase
BME96_RS12285	COG1575	Belongs to the MenA family. Type 1 subfamily
BME96_RS12290	COG2050	protein possibly involved in aromatic compounds catabolism
BME96_RS12295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BME96_RS12300	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BME96_RS12305	COG4412	M6 family metalloprotease domain protein
BME96_RS12305	COG1404	Belongs to the peptidase S8 family
BME96_RS12320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BME96_RS12330	COG1098	S1 RNA binding domain
BME96_RS12335	COG2155	Conserved Protein
BME96_RS12340	COG0166	Belongs to the GPI family
BME96_RS12345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BME96_RS12350	COG2032	superoxide dismutase activity
BME96_RS12365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_RS12370	COG0813	purine-nucleoside phosphorylase activity
BME96_RS12375	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BME96_RS12380	COG3584	3D domain protein
BME96_RS12390	COG1252	NADH dehydrogenase
BME96_RS12395	COG0492	ferredoxin-NADP+ reductase activity
BME96_RS12400	COG0316	Belongs to the HesB IscA family
BME96_RS12405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BME96_RS12410	COG4837	Protein of unknown function (DUF1462)
BME96_RS12415	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BME96_RS12420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME96_RS12425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BME96_RS12430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BME96_RS12435	COG0647	UMP catabolic process
BME96_RS12445	COG2445	Protein of unknown function DUF86
BME96_RS12455	COG0154	amidase activity
BME96_RS12465	COG4470	Protein conserved in bacteria
BME96_RS12475	COG0739	heme binding
BME96_RS12485	COG0733	neurotransmitter:sodium symporter activity
BME96_RS12490	COG1757	Na H antiporter
BME96_RS12505	COG3377	Domain of unknown function (DUF1805)
BME96_RS12510	COG0737	Belongs to the 5'-nucleotidase family
BME96_RS12515	COG0730	response to heat
BME96_RS12525	COG1674	ftsk spoiiie
BME96_RS12545	COG1876	peptidase activity
BME96_RS12715	COG0305	Participates in initiation and elongation during chromosome replication
BME96_RS12730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BME96_RS12750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BME96_RS12800	COG0719	Fe-S assembly protein
BME96_RS12805	COG0822	iron-sulfur transferase activity
BME96_RS12810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BME96_RS12815	COG0719	Fe-S assembly protein
BME96_RS12820	COG0396	ATPase activity
BME96_RS12825	COG1464	Belongs to the NlpA lipoprotein family
BME96_RS12830	COG2011	ABC-type metal ion transport system permease component
BME96_RS12835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BME96_RS12840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_RS12845	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BME96_RS12850	COG0509	glycine decarboxylation via glycine cleavage system
BME96_RS12855	COG1393	Belongs to the ArsC family
BME96_RS12860	COG1960	acyl-CoA dehydrogenase activity
BME96_RS12865	COG0183	Belongs to the thiolase family
BME96_RS12870	COG1024	Enoyl-CoA hydratase
BME96_RS12870	COG1250	3-hydroxyacyl-CoA dehydrogenase
BME96_RS12875	COG0506	proline dehydrogenase activity
BME96_RS12885	COG2217	Heavy metal translocating P-type atpase
BME96_RS12890	COG1937	Protein conserved in bacteria
BME96_RS12895	COG3443	Belongs to the bacterial solute-binding protein 9 family
BME96_RS12895	COG0803	Belongs to the bacterial solute-binding protein 9 family
BME96_RS12900	COG1121	(ABC) transporter
BME96_RS12905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BME96_RS12915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BME96_RS12920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BME96_RS12935	COG0791	NLP P60 protein
BME96_RS12935	COG3883	PFAM NLP P60 protein
BME96_RS12940	COG2224	Isocitrate lyase
BME96_RS12945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BME96_RS12950	COG4129	membrane
BME96_RS12955	COG2197	response regulator
BME96_RS12960	COG4585	Histidine kinase
BME96_RS12965	COG4758	membrane
BME96_RS12980	COG2814	Major facilitator Superfamily
BME96_RS12985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BME96_RS13000	COG1363	Peptidase, m42
BME96_RS13040	COG1388	LysM domain
BME96_RS13050	COG2217	Heavy metal translocating P-type atpase
BME96_RS13055	COG1937	Protein conserved in bacteria
BME96_RS13070	COG5002	protein histidine kinase activity
BME96_RS13080	COG2217	Heavy metal translocating P-type atpase
BME96_RS13085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_RS13090	COG0785	Cytochrome C biogenesis protein
BME96_RS13115	COG5002	protein histidine kinase activity
BME96_RS13120	COG0745	RESPONSE REGULATOR receiver
BME96_RS13130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BME96_RS13200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BME96_RS13205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BME96_RS13210	COG0640	Transcriptional regulator
BME96_RS13215	COG0640	Transcriptional regulator
BME96_RS13235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BME96_RS13240	COG0803	Belongs to the bacterial solute-binding protein 9 family
BME96_RS13245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BME96_RS13250	COG1121	(ABC) transporter
BME96_RS13255	COG0557	exoribonuclease II activity
BME96_RS13260	COG1647	Serine aminopeptidase, S33
BME96_RS13265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BME96_RS13290	COG0148	phosphopyruvate hydratase activity
BME96_RS13295	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BME96_RS13300	COG0149	triose-phosphate isomerase activity
BME96_RS13305	COG0126	phosphoglycerate kinase activity
BME96_RS13325	COG0328	RNA-DNA hybrid ribonuclease activity
BME96_RS13330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BME96_RS13335	COG3162	membrane
BME96_RS13340	COG2610	gluconate transmembrane transporter activity
BME96_RS13345	COG0183	Belongs to the thiolase family
BME96_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS13355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BME96_RS13360	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BME96_RS13375	COG0710	3-dehydroquinate dehydratase activity
BME96_RS13380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BME96_RS13395	COG0740	serine-type endopeptidase activity
BME96_RS13400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_RS13405	COG1481	regulation of sporulation
BME96_RS13410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BME96_RS13415	COG1660	Displays ATPase and GTPase activities
BME96_RS13420	COG1051	belongs to the nudix hydrolase family
BME96_RS13425	COG0492	ferredoxin-NADP+ reductase activity
BME96_RS13430	COG0457	Tetratricopeptide repeat
BME96_RS13435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BME96_RS13440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BME96_RS13445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BME96_RS13450	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BME96_RS13455	COG0110	maltose O-acetyltransferase activity
BME96_RS13460	COG0546	phosphoglycolate phosphatase activity
BME96_RS13465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BME96_RS13470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BME96_RS13475	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BME96_RS13480	COG1950	PFAM Membrane protein of
BME96_RS13485	COG1983	PspC domain protein
BME96_RS13495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BME96_RS13500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BME96_RS13505	COG0556	nucleotide-excision repair
BME96_RS13515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME96_RS13520	COG3409	Peptidoglycan-binding domain 1 protein
BME96_RS13520	COG0793	Belongs to the peptidase S41A family
BME96_RS13525	COG0739	heme binding
BME96_RS13530	COG2177	Part of the ABC transporter FtsEX involved in
BME96_RS13535	COG2884	Cell division ATP-binding protein ftsE
BME96_RS13550	COG0653	protein targeting
BME96_RS13555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BME96_RS13565	COG1516	flagellar protein fliS
BME96_RS13570	COG1334	flagellar protein FlaG
BME96_RS13575	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BME96_RS13580	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BME96_RS13590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BME96_RS13595	COG1256	bacterial-type flagellum assembly
BME96_RS13595	COG4786	Flagellar basal body rod
BME96_RS13615	COG1040	competence protein
BME96_RS13620	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BME96_RS13625	COG1307	EDD domain protein, DegV family
BME96_RS13630	COG2197	response regulator
BME96_RS13635	COG4585	Histidine kinase
BME96_RS13640	COG1739	Uncharacterized protein family UPF0029
BME96_RS13645	COG0363	glucosamine-6-phosphate deaminase activity
BME96_RS13650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BME96_RS13655	COG2190	(PTS) system
BME96_RS13655	COG1263	PTS System
BME96_RS13655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BME96_RS13665	COG1396	sequence-specific DNA binding
BME96_RS13680	COG0681	Belongs to the peptidase S26 family
BME96_RS13700	COG3764	Sortase (surface protein transpeptidase)
BME96_RS13705	COG1316	TRANSCRIPTIONal
BME96_RS13710	COG0768	penicillin binding
BME96_RS13730	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS13740	COG0561	phosphatase activity
BME96_RS13745	COG2814	Major facilitator Superfamily
BME96_RS13750	COG1984	allophanate hydrolase subunit 2
BME96_RS13755	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BME96_RS13760	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BME96_RS13765	COG0471	metal ion transport
BME96_RS13770	COG2814	Major facilitator Superfamily
BME96_RS13775	COG2807	transmembrane transport
BME96_RS13785	COG1368	sulfuric ester hydrolase activity
BME96_RS13800	COG0840	transmembrane signaling receptor activity
BME96_RS13805	COG2200	EAL domain
BME96_RS13810	COG2201	protein-glutamate methylesterase activity
BME96_RS13815	COG0835	chemotaxis
BME96_RS13820	COG2198	Histidine kinase
BME96_RS13820	COG0643	Histidine kinase
BME96_RS13830	COG1360	Flagellar Motor Protein
BME96_RS13835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BME96_RS13840	COG0840	transmembrane signaling receptor activity
BME96_RS13845	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS13850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BME96_RS13855	COG2223	nitrite transmembrane transporter activity
BME96_RS13890	COG0840	transmembrane signaling receptor activity
BME96_RS13900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BME96_RS13905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BME96_RS13910	COG1472	Belongs to the glycosyl hydrolase 3 family
BME96_RS13915	COG3876	Protein conserved in bacteria
BME96_RS13920	COG0395	ABC-type sugar transport system, permease component
BME96_RS13925	COG1175	transmembrane transport
BME96_RS13935	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BME96_RS13940	COG1737	Transcriptional regulator
BME96_RS13945	COG0716	FMN binding
BME96_RS13960	COG1331	Highly conserved protein containing a thioredoxin domain
BME96_RS13990	COG1971	Probably functions as a manganese efflux pump
BME96_RS14005	COG2996	Protein conserved in bacteria
BME96_RS14015	COG4895	conserved protein (DUF2196)
BME96_RS14030	COG0561	phosphatase activity
BME96_RS14050	COG4565	transcriptional regulatory protein
BME96_RS14055	COG3290	protein histidine kinase activity
BME96_RS14060	COG2271	Major facilitator Superfamily
BME96_RS14065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BME96_RS14080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BME96_RS14100	COG0601	transmembrane transport
BME96_RS14105	COG4608	Belongs to the ABC transporter superfamily
BME96_RS14115	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BME96_RS14125	COG0463	Glycosyl transferase, family 2
BME96_RS14135	COG2076	Multidrug Resistance protein
BME96_RS14140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BME96_RS14150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BME96_RS14160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_RS14170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BME96_RS14175	COG0066	3-isopropylmalate dehydratase activity
BME96_RS14180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BME96_RS14185	COG0473	3-isopropylmalate dehydrogenase activity
BME96_RS14190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BME96_RS14195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BME96_RS14200	COG0440	acetolactate synthase activity
BME96_RS14205	COG0028	Belongs to the TPP enzyme family
BME96_RS14210	COG0129	dihydroxy-acid dehydratase activity
BME96_RS14215	COG0385	Bile acid
BME96_RS14220	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BME96_RS14225	COG0473	3-isopropylmalate dehydrogenase activity
BME96_RS14230	COG1757	Na H antiporter
BME96_RS14235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BME96_RS14245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BME96_RS14250	COG1473	amidohydrolase
BME96_RS14255	COG0251	oxidation-reduction process
BME96_RS14260	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS14265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BME96_RS14270	COG1802	Transcriptional regulator
BME96_RS14275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME96_RS14280	COG0006	proline dipeptidase activity
BME96_RS14285	COG0833	amino acid
BME96_RS14290	COG0656	L-ascorbic acid biosynthetic process
BME96_RS14310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BME96_RS14315	COG0805	protein transport
BME96_RS14320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BME96_RS14330	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS14340	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME96_RS14350	COG0583	DNA-binding transcription factor activity
BME96_RS14355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BME96_RS14360	COG0686	Belongs to the AlaDH PNT family
BME96_RS14365	COG2188	Transcriptional regulator
BME96_RS14370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_RS14380	COG0765	amino acid transport
BME96_RS14385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BME96_RS14390	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS14395	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BME96_RS14400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BME96_RS14410	COG3258	Cytochrome c
BME96_RS14415	COG2010	Cytochrome c
BME96_RS14415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BME96_RS14420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME96_RS14440	COG0419	ATPase involved in DNA repair
BME96_RS14445	COG0420	3'-5' exonuclease activity
BME96_RS14460	COG0628	permease
BME96_RS14465	COG1846	Transcriptional regulator
BME96_RS14470	COG2814	Major facilitator Superfamily
BME96_RS14475	COG0351	phosphomethylpyrimidine kinase
BME96_RS14480	COG1122	ATPase activity
BME96_RS14485	COG0390	transport system, permease component
BME96_RS14500	COG2706	6-phosphogluconolactonase activity
BME96_RS14510	COG0516	GMP reductase activity
BME96_RS14520	COG0010	Belongs to the arginase family
BME96_RS14525	COG0786	glutamate:sodium symporter activity
BME96_RS14535	COG1105	Belongs to the carbohydrate kinase PfkB family
BME96_RS14540	COG3684	Belongs to the aldolase LacD family
BME96_RS14555	COG3716	PTS system mannose fructose sorbose family IID component
BME96_RS14560	COG3715	PTS system
BME96_RS14565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BME96_RS14570	COG2222	sugar isomerase
BME96_RS14575	COG2188	Transcriptional regulator
BME96_RS14585	COG1929	Belongs to the glycerate kinase type-1 family
BME96_RS14595	COG3119	arylsulfatase activity
BME96_RS14600	COG5426	von Willebrand factor, type A
BME96_RS14605	COG0395	ABC-type sugar transport system, permease component
BME96_RS14610	COG1175	transmembrane transport
BME96_RS14615	COG1653	transport
BME96_RS14620	COG2207	Transcriptional regulator
BME96_RS14620	COG1917	Cupin 2, conserved barrel domain protein
BME96_RS14625	COG4166	transmembrane transport
BME96_RS14635	COG1609	Transcriptional regulator
BME96_RS14645	COG1316	TRANSCRIPTIONal
BME96_RS14660	COG4166	transmembrane transport
BME96_RS14685	COG1562	ergosterol biosynthetic process
BME96_RS14700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BME96_RS14705	COG0840	transmembrane signaling receptor activity
BME96_RS14710	COG2233	PERMEase
BME96_RS14720	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BME96_RS14730	COG0006	proline dipeptidase activity
BME96_RS14745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BME96_RS14750	COG2223	nitrite transmembrane transporter activity
BME96_RS14760	COG0405	Gamma-glutamyltransferase
BME96_RS14770	COG3764	Sortase (surface protein transpeptidase)
BME96_RS14780	COG1268	BioY protein
BME96_RS14795	COG1757	Na H antiporter
BME96_RS14800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BME96_RS14805	COG3829	transcription factor binding
BME96_RS14805	COG3290	protein histidine kinase activity
BME96_RS14810	COG3383	formate dehydrogenase (NAD+) activity
BME96_RS14815	COG5609	conserved protein (DUF2294)
BME96_RS14820	COG3223	Belongs to the PsiE family
BME96_RS14825	COG1396	sequence-specific DNA binding
BME96_RS14825	COG1917	Cupin 2, conserved barrel domain protein
BME96_RS14830	COG5505	Protein of unknown function (DUF819)
BME96_RS14840	COG0431	NADPH-dependent FMN reductase
BME96_RS14845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BME96_RS14855	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS14865	COG1228	amidohydrolase
BME96_RS14890	COG3541	Predicted nucleotidyltransferase
BME96_RS14905	COG1404	Belongs to the peptidase S8 family
BME96_RS14910	COG2814	Major facilitator Superfamily
BME96_RS14920	COG4948	Mandelate Racemase Muconate Lactonizing
BME96_RS14925	COG1404	Belongs to the peptidase S8 family
BME96_RS14930	COG2027	D-alanyl-D-alanine carboxypeptidase
BME96_RS14935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_RS14945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BME96_RS14950	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BME96_RS14950	COG3291	Pkd domain containing protein
BME96_RS14955	COG1556	Lactate utilization protein
BME96_RS14960	COG1139	Iron-sulfur cluster binding protein
BME96_RS14965	COG0247	lactate metabolic process
BME96_RS14970	COG2186	Transcriptional regulator
BME96_RS14985	COG1737	Transcriptional regulator
BME96_RS14990	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BME96_RS15000	COG2190	(PTS) system
BME96_RS15010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BME96_RS15015	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BME96_RS15030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BME96_RS15035	COG0657	acetylesterase activity
BME96_RS15110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BME96_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS15145	COG2197	response regulator
BME96_RS15165	COG2368	4-hydroxyphenylacetate
BME96_RS15170	COG1132	(ABC) transporter
BME96_RS15180	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS15185	COG0840	transmembrane signaling receptor activity
BME96_RS15200	COG1609	Transcriptional regulator
BME96_RS15215	COG2233	PERMEase
BME96_RS15220	COG0402	S-adenosylhomocysteine deaminase activity
BME96_RS15230	COG3775	system Galactitol-specific IIC component
BME96_RS15240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BME96_RS15245	COG2022	thiamine diphosphate biosynthetic process
BME96_RS15250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME96_RS15255	COG0352	thiamine-phosphate diphosphorylase activity
BME96_RS15265	COG0549	Belongs to the carbamate kinase family
BME96_RS15270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BME96_RS15285	COG1737	Transcriptional regulator
BME96_RS15290	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BME96_RS15295	COG3876	Protein conserved in bacteria
BME96_RS15300	COG1472	Belongs to the glycosyl hydrolase 3 family
BME96_RS15305	COG0395	ABC-type sugar transport system, permease component
BME96_RS15310	COG1175	transmembrane transport
BME96_RS15335	COG0438	transferase activity, transferring glycosyl groups
BME96_RS15345	COG0515	serine threonine protein kinase
BME96_RS15375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BME96_RS15395	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BME96_RS15400	COG1082	Xylose isomerase domain protein TIM barrel
BME96_RS15405	COG0673	inositol 2-dehydrogenase activity
BME96_RS15410	COG0673	inositol 2-dehydrogenase activity
BME96_RS15420	COG0673	inositol 2-dehydrogenase activity
BME96_RS15435	COG1653	transport
BME96_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS15445	COG1609	Transcriptional regulator
BME96_RS15450	COG1473	amidohydrolase
BME96_RS15460	COG1288	antiporter activity
BME96_RS15465	COG4948	Mandelate Racemase Muconate Lactonizing
BME96_RS15490	COG1454	alcohol dehydrogenase
BME96_RS15495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BME96_RS15495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BME96_RS15500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BME96_RS15505	COG2188	Transcriptional regulator
BME96_RS15515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BME96_RS15530	COG2514	catechol 2,3-dioxygenase activity
BME96_RS15535	COG1733	regulation of RNA biosynthetic process
BME96_RS15540	COG3119	arylsulfatase activity
BME96_RS15570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BME96_RS15575	COG0583	DNA-binding transcription factor activity
BME96_RS15605	COG2056	Na+-H+ antiporter family
BME96_RS15610	COG2986	histidine ammonia-lyase
BME96_RS15615	COG3314	Sporulation integral membrane protein YlbJ
BME96_RS15620	COG2195	Cleaves the N-terminal amino acid of tripeptides
BME96_RS15625	COG1228	amidohydrolase
BME96_RS15630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BME96_RS15635	COG0583	DNA-binding transcription factor activity
BME96_RS15645	COG1846	Transcriptional regulator
BME96_RS15650	COG1033	growth of symbiont in host cell
BME96_RS15650	COG2409	Drug exporters of the RND superfamily
BME96_RS15665	COG4166	transmembrane transport
BME96_RS15685	COG1595	DNA-templated transcription, initiation
BME96_RS15705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_RS15710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_RS15715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BME96_RS15725	COG0681	Belongs to the peptidase S26 family
BME96_RS15760	COG0366	Alpha amylase catalytic
BME96_RS15765	COG3345	alpha-galactosidase
BME96_RS15775	COG0561	phosphatase activity
BME96_RS15785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_RS15785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_RS15785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_RS15790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_RS15790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_RS15790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_RS15795	COG1105	Belongs to the carbohydrate kinase PfkB family
BME96_RS15805	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS15810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BME96_RS15815	COG1757	Na H antiporter
BME96_RS15825	COG3938	Belongs to the proline racemase family
BME96_RS15830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME96_RS15855	COG2362	D-Aminopeptidase
BME96_RS15865	COG0366	Alpha amylase catalytic
BME96_RS15875	COG1609	Transcriptional regulator
BME96_RS15905	COG1011	Hydrolase
BME96_RS15910	COG2936	dipeptidyl-peptidase activity
BME96_RS15915	COG0174	glutamine synthetase
BME96_RS15920	COG0493	'glutamate synthase
BME96_RS15925	COG0069	glutamate synthase activity
BME96_RS15925	COG0070	glutamate synthase
BME96_RS15925	COG0067	glutamate synthase
BME96_RS15930	COG0583	DNA-binding transcription factor activity
BME96_RS15935	COG0367	asparagine synthase
BME96_RS15940	COG0446	pyridine nucleotide-disulphide oxidoreductase
BME96_RS15955	COG5444	nuclease activity
BME96_RS15980	COG5298	Protein conserved in bacteria
BME96_RS15985	COG1215	transferase activity, transferring glycosyl groups
BME96_RS16025	COG1757	Na H antiporter
BME96_RS16030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BME96_RS16040	COG1192	Involved in chromosome partitioning
BME96_RS16060	COG3949	Membrane
BME96_RS16065	COG4948	Mandelate Racemase Muconate Lactonizing
BME96_RS16075	COG1473	amidohydrolase
BME96_RS16085	COG1476	TRANSCRIPTIONal
BME96_RS16095	COG1960	acyl-CoA dehydrogenase activity
BME96_RS16100	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_RS16105	COG0789	Transcriptional regulator
BME96_RS16150	COG4166	transmembrane transport
BME96_RS16170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BME96_RS16180	COG1396	sequence-specific DNA binding
BME96_RS16195	COG1522	sequence-specific DNA binding
BME96_RS16200	COG3949	Membrane
BME96_RS16205	COG0010	Belongs to the arginase family
BME96_RS16245	COG1216	Glycosyl transferase, family 2
BME96_RS16245	COG1442	glycosyl transferase family 8
BME96_RS16250	COG0438	transferase activity, transferring glycosyl groups
BME96_RS16255	COG0438	transferase activity, transferring glycosyl groups
BME96_RS16265	COG0438	transferase activity, transferring glycosyl groups
BME96_RS16280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BME96_RS16285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BME96_RS16290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BME96_RS16300	COG2197	response regulator
BME96_RS16310	COG4464	protein tyrosine phosphatase activity
BME96_RS16315	COG0489	protein tyrosine kinase activity
BME96_RS16320	COG3944	biosynthesis protein
BME96_RS16325	COG0791	NLP P60 protein
BME96_RS16325	COG1388	LysM domain
BME96_RS16340	COG1063	alcohol dehydrogenase
BME96_RS16370	COG0165	Argininosuccinate lyase
BME96_RS16380	COG3842	ATPase activity
BME96_RS16385	COG1840	ABC-type Fe3 transport system, periplasmic component
BME96_RS16405	COG1940	carbohydrate kinase activity
BME96_RS16415	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BME96_RS16420	COG1482	cell wall glycoprotein biosynthetic process
BME96_RS16435	COG1175	transmembrane transport
BME96_RS16445	COG2207	Transcriptional regulator
BME96_RS16445	COG4753	response regulator
BME96_RS16450	COG2972	Histidine kinase
BME96_RS16455	COG1879	ABC-type sugar transport system periplasmic component
BME96_RS16470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BME96_RS16485	COG3142	Participates in the control of copper homeostasis
BME96_RS16500	COG3711	transcriptional antiterminator
BME96_RS16510	COG0432	Pfam Uncharacterised protein family UPF0047
BME96_RS16515	COG0745	RESPONSE REGULATOR receiver
BME96_RS16515	COG2972	Histidine kinase
BME96_RS16555	COG1316	TRANSCRIPTIONal
BME96_RS16560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BME96_RS16565	COG0438	transferase activity, transferring glycosyl groups
BME96_RS16575	COG1216	Glycosyl transferase, family 2
BME96_RS16595	COG0584	glycerophosphoryl diester phosphodiesterase
BME96_RS16605	COG1134	teichoic acid transport
BME96_RS16610	COG1682	transport, permease protein
BME96_RS16615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BME96_RS16625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BME96_RS16630	COG0438	transferase activity, transferring glycosyl groups
BME96_RS16635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BME96_RS16645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BME96_RS16650	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BME96_RS16655	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BME96_RS16660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BME96_RS16665	COG1368	sulfuric ester hydrolase activity
BME96_RS16685	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BME96_RS16690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BME96_RS16700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BME96_RS16710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BME96_RS16735	COG2076	Multidrug Resistance protein
BME96_RS16740	COG2076	Multidrug Resistance protein
BME96_RS16750	COG1447	Phosphotransferase system cellobiose-specific component IIA
BME96_RS16760	COG1486	melibiose metabolic process
BME96_RS16765	COG2188	Transcriptional regulator
BME96_RS16770	COG3394	polysaccharide catabolic process
BME96_RS16790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BME96_RS16795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BME96_RS16805	COG1309	transcriptional regulator
BME96_RS16815	COG4980	gas vesicle protein
BME96_RS16825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BME96_RS16835	COG4786	Flagellar basal body rod
BME96_RS16840	COG4786	Flagellar basal body rod
BME96_RS16845	COG1077	Cell shape determining protein MreB Mrl
BME96_RS16855	COG1609	Transcriptional regulator
BME96_RS16865	COG0739	heme binding
BME96_RS16870	COG2385	sporulation resulting in formation of a cellular spore
BME96_RS16875	COG4608	Belongs to the ABC transporter superfamily
BME96_RS16880	COG0791	NLP P60 protein
BME96_RS16885	COG4948	Mandelate Racemase Muconate Lactonizing
BME96_RS16890	COG1619	proteins homologs of microcin C7 resistance protein MccF
BME96_RS16895	COG4166	transmembrane transport
BME96_RS16900	COG0444	Belongs to the ABC transporter superfamily
BME96_RS16905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME96_RS16910	COG0601	transmembrane transport
BME96_RS16915	COG2362	D-Aminopeptidase
BME96_RS16920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BME96_RS16935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BME96_RS16940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BME96_RS16945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BME96_RS16950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BME96_RS16955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BME96_RS16960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BME96_RS16965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BME96_RS16970	COG0356	it plays a direct role in the translocation of protons across the membrane
BME96_RS16980	COG1404	Belongs to the peptidase S8 family
BME96_RS16985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BME96_RS16990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BME96_RS16995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BME96_RS17000	COG4475	Protein of unknown function (DUF436)
BME96_RS17005	COG0698	ribose 5-phosphate isomerase
BME96_RS17015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BME96_RS17020	COG1971	Probably functions as a manganese efflux pump
BME96_RS17035	COG0009	L-threonylcarbamoyladenylate synthase
BME96_RS17050	COG2890	protein-(glutamine-N5) methyltransferase activity
BME96_RS17055	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BME96_RS17060	COG1435	thymidine kinase activity
BME96_RS17065	COG0254	rRNA binding
BME96_RS17070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BME96_RS17075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BME96_RS17080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BME96_RS17085	COG0191	fructose-bisphosphate aldolase activity
BME96_RS17090	COG2204	response regulator
BME96_RS17095	COG0504	CTP synthase activity
BME96_RS17100	COG3343	RNA polymerase activity
BME96_RS17110	COG1703	isobutyryl-CoA mutase activity
BME96_RS17110	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BME96_RS17110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BME96_RS17120	COG1703	isobutyryl-CoA mutase activity
BME96_RS17125	COG1960	acyl-CoA dehydrogenase activity
BME96_RS17130	COG1960	acyl-CoA dehydrogenase activity
BME96_RS17135	COG1250	3-hydroxyacyl-CoA dehydrogenase
BME96_RS17140	COG0183	Belongs to the thiolase family
BME96_RS17145	COG0247	lactate metabolic process
BME96_RS17145	COG2181	nitrate reductase activity
BME96_RS17150	COG0018	arginyl-trna synthetase
BME96_RS17160	COG0010	Belongs to the arginase family
BME96_RS17165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BME96_RS17170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BME96_RS17180	COG3465	dGTPase activity
BME96_RS17185	COG1078	dGTPase activity
BME96_RS17190	COG0095	Lipoate-protein ligase
BME96_RS17195	COG0280	phosphate acetyltransferase
BME96_RS17200	COG3253	May function as heme-dependent peroxidase
BME96_RS17215	COG2363	Small membrane protein
BME96_RS17230	COG0069	glutamate synthase activity
BME96_RS17245	COG3314	Sporulation integral membrane protein YlbJ
BME96_RS17255	COG3594	Acyltransferase
BME96_RS17265	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BME96_RS17270	COG1793	dna ligase
BME96_RS17270	COG3285	dna ligase
BME96_RS17280	COG1764	response to oxidative stress
BME96_RS17290	COG3189	MarR family transcriptional regulator
BME96_RS17295	COG0861	Integral membrane protein TerC family
BME96_RS17300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BME96_RS17305	COG0628	permease
BME96_RS17325	COG1114	Component of the transport system for branched-chain amino acids
BME96_RS17330	COG0514	ATP-dependent DNA helicase (RecQ)
BME96_RS17340	COG1115	amino acid carrier protein
BME96_RS17345	COG1607	acyl-coa hydrolase
BME96_RS17350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BME96_RS17355	COG0626	cystathionine gamma-synthase activity
BME96_RS17360	COG2962	Rard protein
BME96_RS17365	COG2873	o-acetylhomoserine
BME96_RS17370	COG2755	lipolytic protein G-D-S-L family
BME96_RS17375	COG4698	Protein conserved in bacteria
BME96_RS17395	COG0488	(ABC) transporter
BME96_RS17400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BME96_RS17405	COG0156	8-amino-7-oxononanoate synthase activity
BME96_RS17410	COG1388	LysM domain
BME96_RS17410	COG3584	3D domain protein
BME96_RS17410	COG3584	3D domain protein
BME96_RS17410	COG1388	LysM domain
BME96_RS17415	COG4086	secreted protein
BME96_RS17420	COG2814	Major facilitator Superfamily
BME96_RS17430	COG1979	alcohol dehydrogenase
BME96_RS17435	COG0251	oxidation-reduction process
BME96_RS17440	COG0741	lytic transglycosylase activity
BME96_RS17450	COG0534	Mate efflux family protein
BME96_RS17465	COG2358	TRAP transporter, solute receptor (TAXI family
BME96_RS17470	COG0318	PFAM AMP-dependent synthetase and ligase
BME96_RS17475	COG4608	Belongs to the ABC transporter superfamily
BME96_RS17480	COG0444	Belongs to the ABC transporter superfamily
BME96_RS17485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME96_RS17490	COG0601	transmembrane transport
BME96_RS17495	COG4166	transmembrane transport
BME96_RS17505	COG2070	2-Nitropropane dioxygenase
BME96_RS17510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BME96_RS17515	COG2814	Major facilitator Superfamily
BME96_RS17520	COG1737	Transcriptional regulator
BME96_RS17525	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BME96_RS17530	COG2610	gluconate transmembrane transporter activity
BME96_RS17535	COG1070	Carbohydrate kinase
BME96_RS17545	COG1288	antiporter activity
BME96_RS17550	COG2032	superoxide dismutase activity
BME96_RS17560	COG1725	Transcriptional regulator
BME96_RS17565	COG4152	abc transporter atp-binding protein
BME96_RS17580	COG0655	NAD(P)H dehydrogenase (quinone) activity
BME96_RS17585	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME96_RS17585	COG4991	sh3 domain protein
BME96_RS17585	COG3103	Sh3 type 3 domain protein
BME96_RS17595	COG2226	methyltransferase
BME96_RS17615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME96_RS17630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BME96_RS17640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BME96_RS17645	COG0583	DNA-binding transcription factor activity
BME96_RS17650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BME96_RS17655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BME96_RS17680	COG3246	L-lysine catabolic process to acetate
BME96_RS17685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BME96_RS17690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_RS17695	COG2323	membrane
BME96_RS17700	COG0367	asparagine synthase
BME96_RS17710	COG1595	DNA-templated transcription, initiation
BME96_RS17715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BME96_RS17730	COG1115	amino acid carrier protein
BME96_RS17735	COG0753	catalase activity
BME96_RS17740	COG2199	diguanylate cyclase activity
BME96_RS17750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BME96_RS17755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BME96_RS17760	COG0655	NAD(P)H dehydrogenase (quinone) activity
BME96_RS17765	COG0501	Belongs to the peptidase M48B family
BME96_RS17775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BME96_RS17780	COG2197	response regulator
BME96_RS17785	COG4585	Histidine kinase
BME96_RS17790	COG3239	Fatty acid desaturase
BME96_RS17805	COG1199	ATP-dependent helicase activity
BME96_RS17810	COG0427	acetyl-CoA hydrolase
BME96_RS17815	COG3279	Response regulator of the LytR AlgR family
BME96_RS17825	COG1252	NADH dehydrogenase
BME96_RS17830	COG2801	Transposase and inactivated derivatives
BME96_RS17840	COG1346	cytolysis
BME96_RS17845	COG1380	Effector of murein hydrolase LrgA
BME96_RS17850	COG0165	Argininosuccinate lyase
BME96_RS17855	COG0137	argininosuccinate synthase activity
BME96_RS17860	COG2076	Multidrug Resistance protein
BME96_RS17870	COG1309	transcriptional regulator
BME96_RS17875	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS17890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BME96_RS17895	COG0573	inorganic phosphate transmembrane transporter activity
BME96_RS17900	COG0581	inorganic phosphate transmembrane transporter activity
BME96_RS17905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BME96_RS17925	COG2323	membrane
BME96_RS17940	COG2814	Major facilitator Superfamily
BME96_RS17945	COG2404	hydrolase activity, acting on ester bonds
BME96_RS17960	COG1595	DNA-templated transcription, initiation
BME96_RS17980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BME96_RS17995	COG1621	beta-fructofuranosidase activity
BME96_RS18000	COG2190	(PTS) system
BME96_RS18005	COG3871	stress protein (general stress protein 26)
BME96_RS18010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BME96_RS18020	COG3069	C4-dicarboxylate transmembrane transporter activity
BME96_RS18030	COG0709	Synthesizes selenophosphate from selenide and ATP
BME96_RS18035	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BME96_RS18045	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BME96_RS18070	COG1607	acyl-coa hydrolase
BME96_RS18090	COG0583	DNA-binding transcription factor activity
BME96_RS18095	COG1910	domain protein
BME96_RS18100	COG0725	ABC transporter, periplasmic molybdate-binding protein
BME96_RS18105	COG4149	molybdate abc transporter
BME96_RS18110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BME96_RS18120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BME96_RS18130	COG3711	transcriptional antiterminator
BME96_RS18135	COG1263	PTS System
BME96_RS18135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BME96_RS18135	COG2190	(PTS) system
BME96_RS18145	COG1393	Belongs to the ArsC family
BME96_RS18165	COG1999	signal sequence binding
BME96_RS18170	COG1349	DNA-binding transcription factor activity
BME96_RS18180	COG0785	Cytochrome C biogenesis protein
BME96_RS18185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME96_RS18190	COG0745	RESPONSE REGULATOR receiver
BME96_RS18195	COG2205	protein histidine kinase activity
BME96_RS18205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_RS18210	COG0730	response to heat
BME96_RS18215	COG0425	Belongs to the sulfur carrier protein TusA family
BME96_RS18220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_RS18220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_RS18225	COG2210	Belongs to the sulfur carrier protein TusA family
BME96_RS18230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_RS18230	COG0425	Belongs to the sulfur carrier protein TusA family
BME96_RS18235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_RS18240	COG2210	Belongs to the sulfur carrier protein TusA family
BME96_RS18245	COG1937	Protein conserved in bacteria
BME96_RS18255	COG4536	flavin adenine dinucleotide binding
BME96_RS18275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BME96_RS18285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BME96_RS18285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME96_RS18290	COG0456	acetyltransferase
BME96_RS18305	COG2719	SpoVR family
BME96_RS18315	COG2718	Belongs to the UPF0229 family
BME96_RS18320	COG2766	serine protein kinase
BME96_RS18325	COG3639	organic phosphonate transmembrane transporter activity
BME96_RS18330	COG3639	organic phosphonate transmembrane transporter activity
BME96_RS18335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BME96_RS18345	COG0613	PHP domain protein
BME96_RS18350	COG4778	phosphonate C-P lyase system protein PhnL
BME96_RS18355	COG3454	Phosphonate metabolism
BME96_RS18360	COG4107	phosphonate C-P lyase system protein PhnK
BME96_RS18365	COG3627	carbon phosphorus lyase activity
BME96_RS18390	COG2188	Transcriptional regulator
BME96_RS18400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BME96_RS18425	COG0492	ferredoxin-NADP+ reductase activity
BME96_RS18430	COG1120	ATPase activity
BME96_RS18435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BME96_RS18440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_RS18445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME96_RS18470	COG1301	dicarboxylic acid transport
BME96_RS18475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BME96_RS18480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BME96_RS18495	COG2814	Major facilitator Superfamily
BME96_RS18500	COG0617	tRNA 3'-terminal CCA addition
BME96_RS18500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BME96_RS18500	COG0517	IMP dehydrogenase activity
BME96_RS18505	COG1846	Transcriptional regulator
BME96_RS18515	COG1349	DNA-binding transcription factor activity
BME96_RS18520	COG1105	Belongs to the carbohydrate kinase PfkB family
BME96_RS18525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_RS18525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_RS18525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BME96_RS18535	COG1827	regulation of RNA biosynthetic process
BME96_RS18540	COG0157	Belongs to the NadC ModD family
BME96_RS18560	COG1366	Belongs to the anti-sigma-factor antagonist family
BME96_RS18570	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS18580	COG0427	acetyl-CoA hydrolase
BME96_RS18585	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BME96_RS18590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BME96_RS18615	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BME96_RS18655	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BME96_RS18665	COG0666	response to abiotic stimulus
BME96_RS18670	COG0402	S-adenosylhomocysteine deaminase activity
BME96_RS18675	COG0702	epimerase
BME96_RS18690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BME96_RS18695	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS18700	COG1510	regulation of RNA biosynthetic process
BME96_RS18710	COG1012	belongs to the aldehyde dehydrogenase family
BME96_RS18725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BME96_RS18730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME96_RS18730	COG3711	transcriptional antiterminator
BME96_RS18735	COG1486	melibiose metabolic process
BME96_RS18745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BME96_RS18750	COG3394	polysaccharide catabolic process
BME96_RS18755	COG1447	Phosphotransferase system cellobiose-specific component IIA
BME96_RS18760	COG3876	Protein conserved in bacteria
BME96_RS18775	COG3773	Cell wall hydrolase
BME96_RS18790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BME96_RS18795	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BME96_RS18870	COG1028	Short-chain dehydrogenase reductase Sdr
BME96_RS18880	COG1132	(ABC) transporter
BME96_RS18890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME96_RS18895	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BME96_RS18900	COG4853	Protein conserved in bacteria
BME96_RS18905	COG4863	YycH protein
BME96_RS18910	COG5002	protein histidine kinase activity
BME96_RS18915	COG0745	RESPONSE REGULATOR receiver
BME96_RS18920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BME96_RS18925	COG0305	Participates in initiation and elongation during chromosome replication
BME96_RS18930	COG0359	binds to the 23S rRNA
BME96_RS18935	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BME96_RS18940	COG4241	membrane
BME96_RS18950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BME96_RS18955	COG0629	single-stranded DNA binding
BME96_RS18960	COG0360	Binds together with S18 to 16S ribosomal RNA
BME96_RS18965	COG0012	GTP binding
BME96_RS18970	COG4481	Protein conserved in bacteria
BME96_RS18975	COG0668	transmembrane transport
BME96_RS18980	COG3949	Membrane
BME96_RS18995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BME96_RS19000	COG1475	DNA binding
BME96_RS19005	COG1192	Involved in chromosome partitioning
BME96_RS19010	COG1475	DNA binding
BME96_RS19015	COG0357	Ribosomal RNA small subunit methyltransferase G
BME96_RS19020	COG0445	tRNA wobble uridine modification
BME96_RS19025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BME96_RS19030	COG2234	aminopeptidase activity
BME96_RS19035	COG1847	R3H domain protein
BME96_RS19040	COG0706	membrane insertase activity
BME96_RS19045	COG0594	ribonuclease P activity
BME96_RS19050	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BME96_RS19100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BME96_RS19175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BME96_RS19250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BME96_RS19265	COG3425	synthase
BME96_RS19270	COG3425	synthase