locus-tag class description GWK91_RS00005 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GWK91_RS00010 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GWK91_RS00020 ENOG4107QJE Chromosome Partitioning Protein GWK91_RS00065 ENOG4108IUE nitrate reductase beta subunit GWK91_RS00080 ENOG4107V0Z fmn reductase GWK91_RS00085 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein GWK91_RS00105 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GWK91_RS00110 ENOG4106KNT transcriptional regulator GWK91_RS00155 ENOG4105CIG ABC transporter GWK91_RS00165 ENOG41080V3 Major Facilitator superfamily GWK91_RS00175 ENOG4105CDW Resistance protein GWK91_RS00195 ENOG4105S7S phosphonate abc transporter GWK91_RS00200 ENOG4105D5T phosphonate abc transporter GWK91_RS00205 ENOG4107T9Q phosphonate abc transporter GWK91_RS00210 ENOG4105DND Transcriptional regulator GWK91_RS00215 ENOG41063ZK Transcriptional Regulator AraC Family GWK91_RS00270 ENOG4108HUF Transporter GWK91_RS00275 ENOG4105DQ5 transport system permease protein GWK91_RS00280 ENOG4105EHG Permease protein GWK91_RS00295 ENOG4107ZXU DSBA oxidoreductase GWK91_RS00305 ENOG4105DTN riboflavin biosynthesis protein ribF GWK91_RS00325 ENOG4105VMP Transcriptional regulator GWK91_RS00340 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GWK91_RS00370 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GWK91_RS00375 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GWK91_RS00380 ENOG4105EB3 Histidine kinase GWK91_RS00390 ENOG4105CAQ asparagine synthetase GWK91_RS00400 ENOG4105BZU Histidine kinase GWK91_RS00410 ENOG4105CMR udp-glucose 4-epimerase GWK91_RS00425 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GWK91_RS00440 ENOG4105CHR reductase GWK91_RS00445 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS00450 ENOG4108IG5 Transcriptional regulator GWK91_RS00460 ENOG4107RVV histidinol phosphate phosphatase, hisj family GWK91_RS00465 ENOG4108JQ1 Dehydrogenase GWK91_RS00475 ENOG4105CJ1 ABC, transporter GWK91_RS00480 ENOG4108TU7 Inherit from COG: (ABC) transporter GWK91_RS00505 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GWK91_RS00510 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GWK91_RS00525 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GWK91_RS00530 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GWK91_RS00535 ENOG4105FBA Phospholipase Carboxylesterase GWK91_RS00540 ENOG4105CS1 NAD(P)H quinone oxidoreductase GWK91_RS00545 ENOG4105CYN Serine protein kinase GWK91_RS00550 ENOG4107R0W ABC transporter GWK91_RS00555 ENOG4105E5Q amino acid AbC transporter GWK91_RS00560 ENOG4105CDA abc transporter atp-binding protein GWK91_RS00565 ENOG4105PGM cation diffusion facilitator family transporter GWK91_RS00570 ENOG4105KTU Transcriptional regulator, arsr family GWK91_RS00575 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GWK91_RS00580 ENOG4105C7S Dehydrogenase GWK91_RS00585 ENOG4106AKX UPF0229 protein GWK91_RS00595 ENOG4105K4I Scp-like extracellular GWK91_RS00600 ENOG4105D9N nucleoside GWK91_RS00605 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GWK91_RS00620 ENOG4108V2W Carbonate dehydratase GWK91_RS00630 ENOG4105W8X HesB YadR YfhF-family protein GWK91_RS00635 ENOG4105BZ1 (ABC) transporter GWK91_RS00640 ENOG4105BZ1 (ABC) transporter GWK91_RS00645 ENOG4105C0H protease GWK91_RS00650 ENOG4108WZW RNA polymerase sigma GWK91_RS00675 ENOG4105CJ1 ABC, transporter GWK91_RS00680 ENOG4105EMU Dehydrogenase GWK91_RS00695 ENOG4105ED1 spovr family GWK91_RS00700 ENOG4105C94 Transporter GWK91_RS00705 ENOG4105DZ1 carboxypeptidase GWK91_RS00715 ENOG4105CHH sulfate transporter GWK91_RS00720 ENOG4105K4I Scp-like extracellular GWK91_RS00730 ENOG4105C37 (CBS) domain GWK91_RS00735 ENOG4105VC4 domain protein GWK91_RS00745 ENOG4105DWF phosphomethylpyrimidine kinase GWK91_RS00750 ENOG4105KVH Transcriptional regulator GWK91_RS00755 ENOG4107RF6 penicillin-binding protein GWK91_RS00785 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GWK91_RS00805 ENOG4105VRR gCN5-related N-acetyltransferase GWK91_RS00820 ENOG4105EC8 Methyl-accepting chemotaxis GWK91_RS00830 ENOG4105DEU major facilitator superfamily GWK91_RS00840 ENOG4105C9Q fumarate hydratase class II GWK91_RS00865 ENOG4105WZB UPF0342 protein GWK91_RS00875 ENOG4108IUX (ABC) transporter GWK91_RS00880 ENOG4105RHA ABC transporter, permease GWK91_RS00890 ENOG4107VRP DNA repair exonuclease GWK91_RS00895 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GWK91_RS00900 ENOG4107HG4 Transcriptional regulator GWK91_RS00905 ENOG4105EQI Metal Dependent Phosphohydrolase GWK91_RS00915 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GWK91_RS00935 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) GWK91_RS00970 ENOG4108IJ7 Glycine betaine GWK91_RS00990 ENOG4105NBU tryptophan transport protein GWK91_RS00995 ENOG4105K59 histidine triad (HIT) protein GWK91_RS01025 ENOG4105ENE Histidine kinase GWK91_RS01030 ENOG4105WH1 Two component transcriptional regulator luxr family GWK91_RS01045 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GWK91_RS01050 ENOG4105BZ4 penicillin-binding protein GWK91_RS01055 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GWK91_RS01060 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GWK91_RS01065 ENOG4105C1Q protoporphyrinogen oxidase GWK91_RS01075 ENOG4108RQ5 Beta-lactamase domain-containing protein GWK91_RS01080 ENOG4105DF9 Lipoate-protein, ligase GWK91_RS01085 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS01130 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination GWK91_RS01135 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GWK91_RS01140 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GWK91_RS01175 ENOG4105DHF Membrane GWK91_RS01180 ENOG41080UX Methyltransferase GWK91_RS01200 ENOG4105C8Y Acetylornithine aminotransferase GWK91_RS01205 ENOG4105YHS UPF0344 protein GWK91_RS01215 ENOG4105EPR degv family GWK91_RS01220 ENOG4107AYK membrAne GWK91_RS01245 ENOG4105F0I Aminotransferase GWK91_RS01255 ENOG4105S7S phosphonate abc transporter GWK91_RS01260 ENOG4105D5T phosphonate abc transporter GWK91_RS01275 ENOG4108KP7 hydrolase GWK91_RS01280 ENOG4108MXZ Esterase GWK91_RS01285 ENOG4105VG1 fes assembly suf system protein GWK91_RS01295 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E GWK91_RS01300 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GWK91_RS01320 ENOG4107RMD Basic membrane lipoprotein GWK91_RS01325 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GWK91_RS01330 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GWK91_RS01335 ENOG4108RCF TRANSCRIPTIONal GWK91_RS01345 ENOG4108KU1 UPF0736 protein GWK91_RS01350 ENOG4105C31 Tryptophanyl-tRNA synthetase GWK91_RS01380 ENOG4107QSI ABC, transporter GWK91_RS01385 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GWK91_RS01390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GWK91_RS01400 ENOG4108JQ7 (ABC) transporter GWK91_RS01420 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) GWK91_RS01425 ENOG4108ZCF integral membrane protein GWK91_RS01435 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GWK91_RS01445 ENOG4105DPN Oligoendopeptidase f GWK91_RS01450 ENOG4105T58 Dithiol-disulfide isomerase GWK91_RS01455 ENOG4108Z18 K06886 hemoglobin GWK91_RS01460 ENOG4105MIX Adenylate cyclase GWK91_RS01470 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GWK91_RS01475 ENOG4105EMS pseudouridine synthase GWK91_RS01480 ENOG4107S1Q Phosphatase GWK91_RS01490 ENOG4105CJW magnesium transporter GWK91_RS01515 ENOG4105H67 Protein of unknown function (DUF421) GWK91_RS01525 ENOG4108ZMI UPF0477 protein GWK91_RS01535 ENOG4108W5N phosphatidylglycerophosphatase a GWK91_RS01540 ENOG4108P49 AntiSigma factor GWK91_RS01545 ENOG4107RQ2 Cytochrome c oxidase, subunit I GWK91_RS01560 ENOG4105VG1 fes assembly suf system protein GWK91_RS01580 ENOG4105IJJ transcriptional regulator, crp fnr family GWK91_RS01605 ENOG4105E1K spore germination protein GWK91_RS01675 ENOG4105VDT -acetyltransferase GWK91_RS01700 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GWK91_RS01730 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin GWK91_RS01735 ENOG4105DZC cytosine deaminase GWK91_RS01740 ENOG4105DVE abc transporter atp-binding protein GWK91_RS01745 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GWK91_RS01770 ENOG4105C5Q Transcriptional regulator GWK91_RS01775 ENOG4107R37 Glutamate dehydrogenase GWK91_RS01785 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GWK91_RS01790 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GWK91_RS01805 ENOG4108IG5 Transcriptional regulator GWK91_RS01815 ENOG4105DKW ABC transporter GWK91_RS01820 ENOG4105D5T phosphonate abc transporter GWK91_RS01850 ENOG4105K59 histidine triad (HIT) protein GWK91_RS01865 ENOG4105DEN Luciferase family GWK91_RS01870 ENOG4105VKD bioY protein GWK91_RS01900 ENOG4105ME7 Membrane GWK91_RS01930 ENOG4108UZ3 Transporter GWK91_RS01935 ENOG4108TF4 von Willebrand factor, type A GWK91_RS01955 ENOG4108YYS metal-dependent hydrolase (By similarity) GWK91_RS01980 ENOG4105KK4 UPF0060 membrane protein GWK91_RS02030 ENOG4108NHD germination protein GWK91_RS02060 ENOG4106I4J membrane GWK91_RS02085 ENOG4105C1J atp-dependent rna helicase GWK91_RS02090 ENOG4105M6F mutator MutT protein GWK91_RS02105 ENOG4107R7Y intracellular protease Pfpi family GWK91_RS02115 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GWK91_RS02120 ENOG4105CQB FAD linked oxidase domain protein GWK91_RS02125 ENOG41080TC multidrug resistance protein GWK91_RS02130 ENOG410839T multidrug resistance protein GWK91_RS02145 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GWK91_RS02155 ENOG4105CUC YeeE YedE family protein GWK91_RS02160 ENOG4105K63 Thioredoxin GWK91_RS02180 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GWK91_RS02195 ENOG4108UZ3 Transporter GWK91_RS02225 ENOG4107YTP response regulator receiver protein GWK91_RS02240 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GWK91_RS02245 ENOG4105KHC sulfurtransferase GWK91_RS02255 ENOG4105C5Y PTS System GWK91_RS02265 ENOG4105C5Y PTS System GWK91_RS02270 ENOG4105EVU fructokinase GWK91_RS02295 ENOG4105CHM Aminotransferase GWK91_RS02300 ENOG4105E0C molybdate abc transporter GWK91_RS02310 ENOG4108QCI YvbH-like oligomerisation region GWK91_RS02315 ENOG4107Y9E nuclease GWK91_RS02325 ENOG4105CIS alcohol dehydrogenase GWK91_RS02330 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein GWK91_RS02335 ENOG4105E5Q amino acid AbC transporter GWK91_RS02340 ENOG4108Z4U Ferredoxin GWK91_RS02355 ENOG4105E1V na solute symporter GWK91_RS02370 ENOG4107RKG DJ-1/PfpI family GWK91_RS02375 ENOG4105C8Q Methyl-accepting chemotaxis GWK91_RS02390 ENOG4105CBS Chea signal transduction histidine kinase GWK91_RS02395 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis GWK91_RS02400 ENOG4107YTP response regulator receiver protein GWK91_RS02405 ENOG4105C8Q Methyl-accepting chemotaxis GWK91_RS02420 ENOG41082YX Transcriptional regulator, arsr family GWK91_RS02425 ENOG4107R5R arsenical pump membrane protein GWK91_RS02430 ENOG4108UXE Protein tyrosine phosphatase GWK91_RS02435 ENOG4108IJ8 ABC transporter GWK91_RS02440 ENOG4105E90 ABC transporter GWK91_RS02445 ENOG4105DG6 mannose-6-phosphate isomerase GWK91_RS02450 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GWK91_RS02460 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GWK91_RS02465 ENOG4105C2W permease GWK91_RS02470 ENOG4105JHY Membrane GWK91_RS02475 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS02505 ENOG4108594 Permease of the drug metabolite transporter GWK91_RS02520 ENOG4107R0W ABC transporter GWK91_RS02535 ENOG4105CK7 Sodium proline symporter GWK91_RS02560 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GWK91_RS02565 ENOG4105DWF phosphomethylpyrimidine kinase GWK91_RS02570 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GWK91_RS02575 ENOG4108NRW Phospholipase, patatin family GWK91_RS02600 ENOG4105XTG Pfam:DUF156 GWK91_RS02605 ENOG41085GJ domain protein GWK91_RS02610 ENOG4105VFE sira family GWK91_RS02615 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GWK91_RS02620 ENOG4107TPS domain protein GWK91_RS02625 ENOG4105VFE sira family GWK91_RS02630 ENOG41087NI Sulfite exporter TauE/SafE GWK91_RS02640 ENOG4105C4B ABC transporter, permease GWK91_RS02645 ENOG4108IXI (ABC) transporter GWK91_RS02650 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GWK91_RS02655 ENOG4105KPV Transcriptional regulator GWK91_RS02660 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GWK91_RS02665 ENOG4108UZX fmn reductase GWK91_RS02675 ENOG4105C09 Bile acid GWK91_RS02690 ENOG4107QN1 sodium solute GWK91_RS02700 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS02705 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GWK91_RS02775 ENOG4108JYZ YitT family GWK91_RS02805 ENOG4105E33 succinate dehydrogenase GWK91_RS02810 ENOG4105FBW Monooxygenase GWK91_RS02825 ENOG4108B31 Spore germination protein GWK91_RS02840 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) GWK91_RS02855 ENOG4107TB6 phosphoglycerate mutase GWK91_RS02870 ENOG4105F6J Alpha beta hydrolase fold GWK91_RS02875 ENOG4105NQC Flavodoxin GWK91_RS02880 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GWK91_RS02900 ENOG4105CB2 alcohol dehydrogenase GWK91_RS02905 ENOG4105D0U Arsenite-activated ATPase (ArsA) GWK91_RS02915 ENOG4105D22 carbon starvation protein GWK91_RS02940 ENOG4105C7N Xanthine uracil vitamin C permease GWK91_RS02945 ENOG4105C7Z Conserved Protein GWK91_RS02950 ENOG4105KRN Transcriptional regulator, abrb family GWK91_RS02960 ENOG4105KME endoribonuclease L-psp GWK91_RS02970 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GWK91_RS02975 ENOG4108ZAF Molybdopterin GWK91_RS02985 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GWK91_RS02995 ENOG4108JUB Transcriptional regulator GWK91_RS03000 ENOG4108UKI Enoyl-CoA hydratase GWK91_RS03005 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GWK91_RS03020 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS03025 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS03030 ENOG4107QX3 carboxylase GWK91_RS03035 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS03040 ENOG4105DXM phenylacetic acid degradation protein GWK91_RS03050 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GWK91_RS03060 ENOG4105EPU Molybdenum cofactor synthesis domain protein GWK91_RS03065 ENOG4105CVM Molybdenum cofactor synthesis domain protein GWK91_RS03090 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GWK91_RS03095 ENOG4105CH6 catalase GWK91_RS03125 ENOG4105J76 Periplasmic binding protein GWK91_RS03130 ENOG4105S6R Iron-hydroxamate transporter permease subunit GWK91_RS03135 ENOG4105JVQ RNA Polymerase GWK91_RS03145 ENOG4108QY0 Membrane GWK91_RS03200 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GWK91_RS03230 ENOG4107QM2 Aldo Keto reductase GWK91_RS03250 ENOG4105CDU Replicative dna helicase GWK91_RS03255 ENOG4105PNS DnaD domain protein GWK91_RS03290 ENOG4108N23 SpoOM-related protein GWK91_RS03295 ENOG4108V06 Glutathione peroxidase GWK91_RS03315 ENOG4105IIU Aminopeptidase GWK91_RS03330 ENOG4105E4C Lytic transglycosylase catalytic GWK91_RS03335 ENOG4107TT5 NLP P60 protein GWK91_RS03370 ENOG4108DBC nitroreductase GWK91_RS03380 ENOG4105FDF Could be involved in DNA repair (By similarity) GWK91_RS03385 ENOG4105DQE DNA ligase GWK91_RS03390 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GWK91_RS03405 ENOG4108Y1J Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GWK91_RS03460 ENOG4105JFG SpoIID LytB domain protein GWK91_RS03485 ENOG4105C02 permease GWK91_RS03495 ENOG410615F Integral membrane protein (intg_mem_TP0381) GWK91_RS03510 ENOG4105C3M thioredoxin reductase GWK91_RS03525 ENOG4105BZU Histidine kinase GWK91_RS03530 ENOG4105DHI Methyltransferase GWK91_RS03535 ENOG4105C0H protease GWK91_RS03560 ENOG4105C3F Signal peptidase i GWK91_RS03580 ENOG4105C3F Signal peptidase i GWK91_RS03600 ENOG4105CHM Aminotransferase GWK91_RS03625 ENOG4105K8R UPF0145 protein GWK91_RS03630 ENOG4105UIN GWK91_RS03635 ENOG4108KF3 Electron transport protein SCO1 SenC GWK91_RS03645 ENOG4108UT2 hemolysin iii GWK91_RS03665 ENOG4105CH2 amidohydrolase GWK91_RS03670 ENOG4106AUC UPF0180 protein GWK91_RS03675 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GWK91_RS03680 ENOG4105D8X mechanosensitive ion channel GWK91_RS03685 ENOG4105D3R alkyl hydroperoxide reductase GWK91_RS03690 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GWK91_RS03705 ENOG4105BZ1 (ABC) transporter GWK91_RS03710 ENOG4105BZ1 (ABC) transporter GWK91_RS03720 ENOG4107ZYR domain protein GWK91_RS03725 ENOG4105CN5 Metallo-Beta-Lactamase GWK91_RS03730 ENOG4106148 UPF0356 protein GWK91_RS03735 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GWK91_RS03750 ENOG4105CPP Dehydrogenase, E1 component GWK91_RS03770 ENOG4105C94 Transporter GWK91_RS03780 ENOG4108ZJ4 polysaccharide deacetylase GWK91_RS03795 ENOG4105EA8 2-Nitropropane dioxygenase GWK91_RS03800 ENOG4105WBI UPF0223 protein GWK91_RS03805 ENOG4108WQ8 UPF0637 protein GWK91_RS03810 ENOG4105ECY inositol monophosphatase GWK91_RS03820 ENOG4105QA2 GWK91_RS03840 ENOG4108IAB Phoh family GWK91_RS03850 ENOG4105CSV Glutaminase GWK91_RS03855 ENOG4105ZPI UPF0358 protein GWK91_RS03860 ENOG4105CNI cell division protein FtsW GWK91_RS03865 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GWK91_RS03870 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GWK91_RS03875 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GWK91_RS03885 ENOG4105BZ9 Cytochrome C oxidase, subunit I GWK91_RS03895 ENOG41064X9 cytochrome C oxidase subunit IV GWK91_RS03925 ENOG41080XQ Signal transduction protein with cbs domains GWK91_RS03930 ENOG4106UY4 Inherit from COG: Scp-like extracellular GWK91_RS03950 ENOG4105WUC UPF0298 protein GWK91_RS03960 ENOG4106H78 methyltransferase GWK91_RS03970 ENOG4105H20 Sporulation integral membrane protein YlbJ GWK91_RS03975 ENOG4105D78 K07001 NTE family protein GWK91_RS03980 ENOG41063PX domain protein GWK91_RS03985 ENOG4105CDE UPF0348 protein GWK91_RS03990 ENOG4105KNH Nucleic acid-binding protein GWK91_RS03995 ENOG41067VY 50S ribosomal protein L32 GWK91_RS04000 ENOG4105E39 Enoyl-CoA hydratase GWK91_RS04010 ENOG4108YG3 N-acetyltransferase GWK91_RS04025 ENOG41074B2 UPF0747 protein GWK91_RS04030 ENOG4108V6E Cell division protein mraZ GWK91_RS04035 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GWK91_RS04045 ENOG4105CJN penicillin-binding protein GWK91_RS04050 ENOG4105CJN penicillin-binding protein GWK91_RS04055 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GWK91_RS04060 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GWK91_RS04065 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GWK91_RS04070 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GWK91_RS04075 ENOG4105CNI cell division protein FtsW GWK91_RS04080 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GWK91_RS04085 ENOG4108R2U division initiation protein GWK91_RS04095 ENOG4105K67 small basic protein GWK91_RS04100 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GWK91_RS04105 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GWK91_RS04115 ENOG4105FFI sigma-e processing peptidase spoiiga GWK91_RS04120 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWK91_RS04130 ENOG4105WR5 sporulation protein, YlmC YmxH family GWK91_RS04135 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GWK91_RS04140 ENOG4105DFA alanine racemase domain protein GWK91_RS04145 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GWK91_RS04150 ENOG41067XK integral membrane protein GWK91_RS04155 ENOG4105DBK s4 domain protein GWK91_RS04165 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GWK91_RS04170 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GWK91_RS04175 ENOG4105C34 Pseudouridine synthase GWK91_RS04180 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GWK91_RS04205 ENOG4105DSJ YicC domain protein GWK91_RS04210 ENOG4105KC4 UPF0296 protein GWK91_RS04215 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GWK91_RS04220 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GWK91_RS04225 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GWK91_RS04230 ENOG4105C25 Primosomal protein n' GWK91_RS04235 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GWK91_RS04240 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GWK91_RS04245 ENOG4108ZF3 Phosphatase GWK91_RS04250 ENOG4105D9P serine threonine protein kinase GWK91_RS04255 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GWK91_RS04260 ENOG4105DJV ribulose-phosphate 3-epimerase GWK91_RS04265 ENOG4105FJ0 thiamine GWK91_RS04275 ENOG4105VB9 50S ribosomal protein l28 GWK91_RS04280 ENOG4108ZAA Alkaline-shock protein GWK91_RS04285 ENOG4105DP4 dak2 domain fusion protein ylov GWK91_RS04295 ENOG4105EJQ L-serine dehydratase GWK91_RS04300 ENOG4105CB5 ATP-dependent DNA helicase recG GWK91_RS04305 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) GWK91_RS04310 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GWK91_RS04315 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GWK91_RS04320 ENOG4105CHR reductase GWK91_RS04325 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GWK91_RS04335 ENOG4108CPA Protein of unknown function (DUF1128) GWK91_RS04340 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GWK91_RS04345 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GWK91_RS04350 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GWK91_RS04360 ENOG4105K5M 30s ribosomal protein S16 GWK91_RS04365 ENOG4105VB6 UPF0109 protein GWK91_RS04375 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GWK91_RS04380 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GWK91_RS04385 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GWK91_RS04395 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GWK91_RS04420 ENOG4105CMV Succinyl-CoA synthetase subunit beta GWK91_RS04425 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GWK91_RS04430 ENOG4105C79 DNA protecting protein DprA GWK91_RS04435 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GWK91_RS04440 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GWK91_RS04445 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GWK91_RS04450 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GWK91_RS04460 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GWK91_RS04465 ENOG4108ZC9 flagellar basal-body rod protein flgc GWK91_RS04470 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GWK91_RS04475 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GWK91_RS04480 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GWK91_RS04510 ENOG410822I Flagellar hook capping protein GWK91_RS04520 ENOG4108JQA flagellar GWK91_RS04525 ENOG41068WV flagellar FlbD family protein GWK91_RS04535 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GWK91_RS04540 ENOG4105DD5 Flagellar motor switch protein GWK91_RS04545 ENOG4107YTP response regulator receiver protein GWK91_RS04555 ENOG4105CN7 Flagellar biosynthetic protein FliP GWK91_RS04560 ENOG4105VS8 Flagellar biosynthetic protein fliq GWK91_RS04565 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GWK91_RS04575 ENOG4105D7B Flagellar biosynthesis protein flha GWK91_RS04580 ENOG4105FZW flagellar biosynthesis regulator FlhF GWK91_RS04590 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GWK91_RS04595 ENOG4108V3W Chemotaxis protein, CheW GWK91_RS04605 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GWK91_RS04610 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWK91_RS04630 ENOG4105CE9 30S ribosomal protein S2 GWK91_RS04635 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GWK91_RS04640 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GWK91_RS04645 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GWK91_RS04650 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GWK91_RS04655 ENOG4105KNE Phosphatidate cytidylyltransferase GWK91_RS04665 ENOG4105DZP Membrane-associated zinc metalloprotease GWK91_RS04670 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GWK91_RS04675 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GWK91_RS04685 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GWK91_RS04690 ENOG4105CHV Transcription elongation factor NusA GWK91_RS04695 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GWK91_RS04705 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GWK91_RS04710 ENOG4105W7A Protein of unknown function (DUF503) GWK91_RS04715 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GWK91_RS04720 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GWK91_RS04725 ENOG4105DTN riboflavin biosynthesis protein ribF GWK91_RS04730 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GWK91_RS04735 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GWK91_RS04750 ENOG4105C1V Peptidase, M16 GWK91_RS04760 ENOG4105E35 Dipicolinate synthase subunit A GWK91_RS04765 ENOG4108S0H Dipicolinic acid synthetase, b subunit GWK91_RS04770 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GWK91_RS04780 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GWK91_RS04785 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GWK91_RS04795 ENOG4105CNU cell division protein FtsK GWK91_RS04800 ENOG4105FDP GntR family transcriptional regulator GWK91_RS04815 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GWK91_RS04820 ENOG4105XZV Protein of unknown function (DUF3243) GWK91_RS04835 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GWK91_RS04840 ENOG4105CEV competence damage-inducible protein GWK91_RS04845 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GWK91_RS04850 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GWK91_RS04855 ENOG4105D48 metallophosphoesterase GWK91_RS04860 ENOG4105MCT stage V sporulation protein S GWK91_RS04870 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GWK91_RS04875 ENOG4105DQU oxidoreductase, subunit beta GWK91_RS04880 ENOG4105ECP epimerase GWK91_RS04890 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GWK91_RS04905 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GWK91_RS04910 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GWK91_RS04915 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GWK91_RS04920 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GWK91_RS04925 ENOG4106F1P AAA ATPase, central domain protein GWK91_RS04930 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GWK91_RS04935 ENOG4105CXI aluminum resistance protein GWK91_RS04940 ENOG4105KV4 Transcriptional regulator GWK91_RS04945 ENOG4105C5F glutamine synthetase GWK91_RS04950 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GWK91_RS04955 ENOG4108SVB resolvase GWK91_RS04960 ENOG4105VPS UPF0291 protein GWK91_RS04965 ENOG4105CV1 Transketolase (EC 2.2.1.1) GWK91_RS04975 ENOG4105VXM UPF0154 protein GWK91_RS04980 ENOG4107QIV Cytochrome c biogenesis protein GWK91_RS04985 ENOG4105HC0 Na H antiporter GWK91_RS04990 ENOG4107YTP response regulator receiver protein GWK91_RS05015 ENOG4105BZU Histidine kinase GWK91_RS05020 ENOG4105EM7 Selenocysteine-specific translation elongation factor GWK91_RS05035 ENOG41076DU acid-soluble spore protein P GWK91_RS05040 ENOG4108I0Z Aconitate hydratase GWK91_RS05045 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GWK91_RS05060 ENOG41067CD Small, acid-soluble spore protein Tlp GWK91_RS05070 ENOG4105MI2 GWK91_RS05075 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GWK91_RS05080 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) GWK91_RS05085 ENOG4105PNM synthesis protein GWK91_RS05090 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GWK91_RS05095 ENOG4105K4P CoA-binding domain protein GWK91_RS05100 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GWK91_RS05120 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS05125 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GWK91_RS05130 ENOG4105E39 Enoyl-CoA hydratase GWK91_RS05135 ENOG4107QX3 carboxylase GWK91_RS05140 ENOG41089UC methyltransferase, type 11 GWK91_RS05150 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GWK91_RS05155 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 GWK91_RS05160 ENOG4105CZM Major Facilitator GWK91_RS05165 ENOG4108IEG Formate dehydrogenase Alpha subunit GWK91_RS05180 ENOG4105TMB Formate nitrite transporter GWK91_RS05210 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GWK91_RS05230 ENOG4105D06 uba thif-type nad fad binding protein GWK91_RS05235 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GWK91_RS05240 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GWK91_RS05245 ENOG41080HI glycine oxidase GWK91_RS05250 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GWK91_RS05255 ENOG4105ETU transcriptional activator (TenA GWK91_RS05290 ENOG4105ENY Ethanolamine utilization protein eutH GWK91_RS05295 ENOG4105CPF Cell wall formation (By similarity) GWK91_RS05300 ENOG4108VKI Cell wall hydrolase GWK91_RS05305 ENOG4105DMF Dehydrogenase GWK91_RS05315 ENOG4105FGV Chromate GWK91_RS05320 ENOG4105FGV Chromate GWK91_RS05325 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GWK91_RS05330 ENOG4105CYC Transferase GWK91_RS05335 ENOG4105DY9 regulatoR GWK91_RS05340 ENOG4107E6A Cytochrome p-450 GWK91_RS05370 ENOG4105EN6 Membrane GWK91_RS05405 ENOG4105WQG acetyltransferase GWK91_RS05415 ENOG4105CEP NADH dehydrogenase GWK91_RS05430 ENOG4108IV0 ABC, transporter GWK91_RS05435 ENOG4105C0Z ABC transporter GWK91_RS05440 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GWK91_RS05445 ENOG4105C32 Amino acid ABC transporter (Permease) GWK91_RS05450 ENOG4105E39 Enoyl-CoA hydratase GWK91_RS05455 ENOG4108N5B 2-phosphosulfolactate phosphatase GWK91_RS05465 ENOG4105CHU acetyl-coa acetyltransferase GWK91_RS05470 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS05485 ENOG4105CHR reductase GWK91_RS05490 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS05495 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS05505 ENOG4105CHR reductase GWK91_RS05525 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GWK91_RS05535 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GWK91_RS05560 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family GWK91_RS05565 ENOG4105QNR S1 RNA binding domain protein GWK91_RS05585 ENOG4108YBP pseudouridine synthase GWK91_RS05610 ENOG4105SXS Protein of unknown function (DUF456) GWK91_RS05640 ENOG4105DEN Luciferase family GWK91_RS05645 ENOG410900G Protein of unknown function (DUF421) GWK91_RS05660 ENOG4108IUE nitrate reductase beta subunit GWK91_RS05685 ENOG4105BZU Histidine kinase GWK91_RS05710 ENOG4105C28 cystathionine GWK91_RS05725 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GWK91_RS05735 ENOG4105N80 Ferric uptake regulator, Fur family GWK91_RS05740 ENOG4105CH6 catalase GWK91_RS05745 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GWK91_RS05750 ENOG4107T89 von Willebrand factor, type A GWK91_RS05775 ENOG4105QEK Transcriptional regulator GWK91_RS05780 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GWK91_RS05785 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GWK91_RS05790 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GWK91_RS05795 ENOG4107V6Q Cyclic nucleotide-binding domain GWK91_RS05800 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GWK91_RS05815 ENOG4105R3A Nitrate reductase GWK91_RS05820 ENOG4108IUE nitrate reductase beta subunit GWK91_RS05885 ENOG4105BZU Histidine kinase GWK91_RS05890 ENOG4108HGU Histidine kinase GWK91_RS05895 ENOG4105C5H ABC transporter GWK91_RS05900 ENOG4105C1J atp-dependent rna helicase GWK91_RS05905 ENOG410890F Dynamin family GWK91_RS05910 ENOG4105KXX peptidase s58 dmpa GWK91_RS05935 ENOG4105PW4 Sugar fermentation stimulation protein homolog GWK91_RS05945 ENOG4105E0X reductase GWK91_RS05955 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GWK91_RS05960 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GWK91_RS05965 ENOG4105C72 UPF0176 protein GWK91_RS05975 ENOG4105EYH Exonuclease GWK91_RS05980 ENOG4107RFY SbcCD D subunit GWK91_RS05995 ENOG4105VSD UPF0346 protein GWK91_RS06000 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GWK91_RS06005 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GWK91_RS06010 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GWK91_RS06020 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GWK91_RS06035 ENOG4105I3N Conserved Protein GWK91_RS06045 ENOG4105VEQ Cold shock protein GWK91_RS06050 ENOG4105E4C Lytic transglycosylase catalytic GWK91_RS06065 ENOG41065KQ synthase GWK91_RS06070 ENOG4105CHR reductase GWK91_RS06080 ENOG4105NAA Cytochrome C oxidase, subunit II GWK91_RS06085 ENOG4107RQ2 Cytochrome c oxidase, subunit I GWK91_RS06090 ENOG4105CTD carboxy-peptidase GWK91_RS06095 ENOG4108ZRV stage ii sporulation protein p GWK91_RS06100 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GWK91_RS06110 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) GWK91_RS06115 ENOG4108UKS UPF0398 protein GWK91_RS06125 ENOG4105KG3 cytidine deaminase GWK91_RS06145 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GWK91_RS06150 ENOG4105BZ4 penicillin-binding protein GWK91_RS06155 ENOG4105CSM endonuclease III GWK91_RS06165 ENOG4105C5S asparaginyl-tRNA synthetase GWK91_RS06170 ENOG4105CHM Aminotransferase GWK91_RS06180 ENOG4105YAC GWK91_RS06190 ENOG4105DVT helicase GWK91_RS06195 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GWK91_RS06200 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GWK91_RS06215 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GWK91_RS06220 ENOG4105CPK Glycosyl transferase (Group 1 GWK91_RS06225 ENOG4108Z5K methylglyoxal synthase GWK91_RS06230 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GWK91_RS06235 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GWK91_RS06240 ENOG4108JYZ YitT family GWK91_RS06260 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit GWK91_RS06265 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GWK91_RS06270 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GWK91_RS06285 ENOG41068YB TPR repeat-containing protein GWK91_RS06295 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GWK91_RS06305 ENOG4105CIH Imidazole acetol-phosphate transaminase GWK91_RS06310 ENOG4105KHN chorismate mutase GWK91_RS06315 ENOG4105D49 3-dehydroquinate synthase GWK91_RS06320 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GWK91_RS06325 ENOG4105BZU Histidine kinase GWK91_RS06330 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GWK91_RS06335 ENOG4105EAH synthase GWK91_RS06340 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GWK91_RS06350 ENOG4105WP2 Tryptophan RNA-binding attenuator protein GWK91_RS06360 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GWK91_RS06380 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GWK91_RS06385 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GWK91_RS06395 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GWK91_RS06400 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GWK91_RS06405 ENOG4105F6E Acyl-transferase GWK91_RS06410 ENOG4105CAT Cytidine monophosphate kinase GWK91_RS06425 ENOG4105MSI germination protein ypeb GWK91_RS06430 ENOG4105F0V Cell wall hydrolase GWK91_RS06440 ENOG4105HDK L-asparaginase GWK91_RS06445 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GWK91_RS06455 ENOG4108S6Z Negative regulator of genetic competence GWK91_RS06460 ENOG4107RGJ metallophosphoesterase GWK91_RS06480 ENOG4105C9U ATP-dependent DNA helicase RecQ GWK91_RS06485 ENOG4105T7X GWK91_RS06505 ENOG4105BZU Histidine kinase GWK91_RS06510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GWK91_RS06515 ENOG4105CRE cytochrome C GWK91_RS06520 ENOG4107TWT Cytochrome c biogenesis protein GWK91_RS06525 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GWK91_RS06530 ENOG4105FE9 pseudouridine synthase GWK91_RS06540 ENOG4108JIC nucleoside recognition domain protein GWK91_RS06545 ENOG4105DZ1 carboxypeptidase GWK91_RS06550 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GWK91_RS06560 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GWK91_RS06565 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GWK91_RS06590 ENOG4107ZE5 PPIases accelerate the folding of proteins GWK91_RS06595 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GWK91_RS06610 ENOG4105CZ3 stage V sporulation protein ad GWK91_RS06615 ENOG41090VF Stage v sporulation protein ac GWK91_RS06630 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWK91_RS06635 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GWK91_RS06640 ENOG41082AN stage II sporulation protein GWK91_RS06645 ENOG4105DZ1 carboxypeptidase GWK91_RS06650 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GWK91_RS06660 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GWK91_RS06665 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GWK91_RS06675 ENOG4105I3K Ferric uptake regulator, Fur family GWK91_RS06680 ENOG4105MZ9 stage II sporulation protein m GWK91_RS06690 ENOG4108YZ4 nudix hydrolase GWK91_RS06695 ENOG4105CPC Aldo Keto reductase GWK91_RS06700 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GWK91_RS06705 ENOG4105KNA -acetyltransferase GWK91_RS06710 ENOG4108UIN ybak prolyl-trna synthetase associated region GWK91_RS06715 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GWK91_RS06720 ENOG4105CS9 pantothenic acid kinase GWK91_RS06725 ENOG4108IXY short-chain dehydrogenase reductase GWK91_RS06730 ENOG41069FQ Metallo-beta-lactamase superfamily GWK91_RS06740 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GWK91_RS06745 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GWK91_RS06755 ENOG4105C26 Dehydrogenase GWK91_RS06760 ENOG4105C7N Xanthine uracil vitamin C permease GWK91_RS06765 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GWK91_RS06770 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GWK91_RS06780 ENOG4105C9U ATP-dependent DNA helicase RecQ GWK91_RS06795 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GWK91_RS06800 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GWK91_RS06805 ENOG4108HNZ carboxyl transferase GWK91_RS06810 ENOG4108ZVT methylmalonyl-coA epimerase GWK91_RS06815 ENOG4105D5P Methylmalonyl-coA mutase GWK91_RS06820 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS06825 ENOG4105EA8 2-Nitropropane dioxygenase GWK91_RS06830 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GWK91_RS06835 ENOG4105CHU acetyl-coa acetyltransferase GWK91_RS06840 ENOG4107Z3H Transcriptional regulator, TetR family GWK91_RS06850 ENOG4108QEG Membrane GWK91_RS06855 ENOG4108Y6J UPF0403 protein GWK91_RS06865 ENOG4105C7S Dehydrogenase GWK91_RS06870 ENOG4105CPP Dehydrogenase, E1 component GWK91_RS06900 ENOG4108JUB Transcriptional regulator GWK91_RS06910 ENOG4105CFH Aspartokinase GWK91_RS06945 ENOG4108IQE Amp-dependent synthetase and ligase GWK91_RS06960 ENOG4105CHU acetyl-coa acetyltransferase GWK91_RS06970 ENOG4105E39 Enoyl-CoA hydratase GWK91_RS06975 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS06980 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS06990 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GWK91_RS06995 ENOG4107QQR Sporulation GWK91_RS07000 ENOG4105S1Z Stage IV sporulation protein B GWK91_RS07005 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GWK91_RS07010 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GWK91_RS07015 ENOG4105DX0 Hemolysin A GWK91_RS07020 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GWK91_RS07030 ENOG4105CTB Polyprenyl synthetase GWK91_RS07035 ENOG41084DP Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GWK91_RS07045 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GWK91_RS07050 ENOG4105M7K Involved in the transcription termination process (By similarity) GWK91_RS07055 ENOG4108ZSR alkaline shock protein GWK91_RS07060 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GWK91_RS07080 ENOG410644B Stage III sporulation protein af GWK91_RS07090 ENOG4105KQ4 Stage iii sporulation protein ad GWK91_RS07095 ENOG4108CQH stage III sporulation protein AC GWK91_RS07100 ENOG4105KR5 Stage iii sporulation protein GWK91_RS07105 ENOG4105CD2 stage iii sporulation protein aa GWK91_RS07110 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GWK91_RS07115 ENOG4105DC7 peptidase M24 GWK91_RS07120 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GWK91_RS07140 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GWK91_RS07145 ENOG4105WZW rhodanese family GWK91_RS07155 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GWK91_RS07160 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GWK91_RS07165 ENOG4105C0D helicase GWK91_RS07240 ENOG4105C5X domain protein GWK91_RS07250 ENOG4105E0M Sulfatase GWK91_RS07255 ENOG4105DKQ ROK family GWK91_RS07275 ENOG4107ZXI Rhomboid family GWK91_RS07285 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GWK91_RS07305 ENOG4108UTW Plays a role in the regulation of phosphate uptake GWK91_RS07315 ENOG4105E2Z phosphate ABC transporter (Permease GWK91_RS07320 ENOG4105C8U phosphate abc transporter GWK91_RS07330 ENOG4107RF6 penicillin-binding protein GWK91_RS07390 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GWK91_RS07395 ENOG41063Y9 GWK91_RS07400 ENOG41069ZM Protein of unknown function (DUF2624) GWK91_RS07405 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GWK91_RS07415 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GWK91_RS07420 ENOG4105EGD dinuclear metal center protein, YbgI family GWK91_RS07440 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWK91_RS07445 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GWK91_RS07450 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GWK91_RS07460 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) GWK91_RS07470 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GWK91_RS07475 ENOG41080IJ Diacylglycerol kinase GWK91_RS07480 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GWK91_RS07485 ENOG4105CTJ Metal Dependent Phosphohydrolase GWK91_RS07490 ENOG4105C9A Phoh family GWK91_RS07495 ENOG4105EI1 sporulation protein yqfd GWK91_RS07500 ENOG41068P3 sporulation protein YqfC GWK91_RS07510 ENOG4105DI5 UPF0365 protein GWK91_RS07515 ENOG4105F7J membrane-bound serine protease GWK91_RS07520 ENOG4105KTH gatB Yqey GWK91_RS07525 ENOG4105VCC 30S ribosomal protein S21 GWK91_RS07535 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GWK91_RS07565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GWK91_RS07570 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GWK91_RS07575 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GWK91_RS07580 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GWK91_RS07585 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GWK91_RS07590 ENOG4105CFG Acts as a chaperone (By similarity) GWK91_RS07595 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GWK91_RS07605 ENOG4105CSA Coproporphyrinogen iii oxidase GWK91_RS07610 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GWK91_RS07625 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GWK91_RS07630 ENOG4105TQK DNA polymerase iii, delta' subunit GWK91_RS07640 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GWK91_RS07645 ENOG4108UK2 deaminase GWK91_RS07650 ENOG4105KQC Competence protein GWK91_RS07660 ENOG4107TCE N-acetyltransferase GWK91_RS07665 ENOG4105DXX methyltransferase GWK91_RS07675 ENOG4108WF2 Metal Dependent Phosphohydrolase GWK91_RS07680 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GWK91_RS07685 ENOG410812S Rna-binding protein GWK91_RS07690 ENOG4105E2X shikimate dehydrogenase GWK91_RS07695 ENOG4105CQW ribosome biogenesis GTPase YqeH GWK91_RS07700 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GWK91_RS07710 ENOG4105D65 subunit l GWK91_RS07715 ENOG4108ZE9 Monovalent cation H antiporter subunit C GWK91_RS07720 ENOG4108JPZ Monovalent cation H antiporter subunit D GWK91_RS07725 ENOG4105SC1 monovalent cation H antiporter subunit E GWK91_RS07735 ENOG4105KJM monovalent cation h antiporter subunit g GWK91_RS07740 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWK91_RS07750 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GWK91_RS07765 ENOG4107XRG penicillin-binding protein GWK91_RS07770 ENOG4107XRG penicillin-binding protein GWK91_RS07775 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GWK91_RS07780 ENOG4105DBI uridine monophosphokinase GWK91_RS07790 ENOG4105HHA aminodeoxychorismate lyase GWK91_RS07800 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GWK91_RS07805 ENOG4105VBH UPF0297 protein GWK91_RS07810 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GWK91_RS07815 ENOG4105C02 permease GWK91_RS07820 ENOG41060CR GWK91_RS07825 ENOG4105C7H Helicase, RecD TraA family GWK91_RS07835 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GWK91_RS07840 ENOG4105C3J Cysteine desulfurase GWK91_RS07855 ENOG4105D1H recombination factor protein RarA GWK91_RS07860 ENOG4108VCI transcription factor, rsfa family GWK91_RS07865 ENOG4105CDH Citrulline--aspartate ligase GWK91_RS07870 ENOG4105CH7 arginosuccinase GWK91_RS07875 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GWK91_RS07880 ENOG4108K60 carbamoyl-phosphate synthetase ammonia chain GWK91_RS07885 ENOG4105DBV ornithine carbamoyltransferase GWK91_RS07895 ENOG4105C9M aspartyl-trna synthetase GWK91_RS07900 ENOG4105CUT histidyl-tRNA synthetase GWK91_RS07910 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GWK91_RS07915 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GWK91_RS07920 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GWK91_RS07925 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GWK91_RS07930 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GWK91_RS07935 ENOG41067VP Protein of unknown function (DUF1049) GWK91_RS07940 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GWK91_RS07950 ENOG4105CKP Polysaccharide Biosynthesis Protein GWK91_RS07955 ENOG4108QG2 Membrane GWK91_RS07960 ENOG4107R3E Citrate transporter GWK91_RS07965 ENOG4105NAP GWK91_RS07970 ENOG4105VIE preprotein translocase, subunit YajC GWK91_RS07975 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GWK91_RS07980 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GWK91_RS07990 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GWK91_RS07995 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GWK91_RS08005 ENOG4105CDY transcriptional regulatory protein GWK91_RS08015 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GWK91_RS08020 ENOG4106678 morphogenetic protein associated with SpoVID GWK91_RS08025 ENOG4105CQC Prephenate dehydratase GWK91_RS08030 ENOG41090I5 UPF0735 ACT domain-containing protein GWK91_RS08035 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GWK91_RS08045 ENOG4105K46 50S ribosomal protein l27 GWK91_RS08050 ENOG4105X36 (ribosomal) protein GWK91_RS08055 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GWK91_RS08060 ENOG4105C03 ribonuclease GWK91_RS08075 ENOG4108YZA Nitrogen regulatory protein pii GWK91_RS08085 ENOG4105CAQ asparagine synthetase GWK91_RS08090 ENOG4107QMS site-determining protein GWK91_RS08095 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GWK91_RS08110 ENOG4105DFF Rod shape-determining protein mreb GWK91_RS08115 ENOG4105W5Q DNA repair protein (RadC GWK91_RS08120 ENOG4108Z03 MAF-like protein GWK91_RS08135 ENOG4105BZU Histidine kinase GWK91_RS08140 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GWK91_RS08145 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GWK91_RS08160 ENOG41068KH stage VI sporulation protein D GWK91_RS08160 ENOG41068KH stage VI sporulation protein D GWK91_RS08165 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GWK91_RS08170 ENOG4105D52 delta-aminolevulinic acid dehydratase GWK91_RS08175 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GWK91_RS08180 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GWK91_RS08190 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GWK91_RS08200 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GWK91_RS08205 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GWK91_RS08210 ENOG4108IUQ atp-dependent protease GWK91_RS08215 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GWK91_RS08220 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GWK91_RS08265 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GWK91_RS08270 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GWK91_RS08275 ENOG4108XJQ germination protein GWK91_RS08285 ENOG41067TZ transcriptional regulator, MarR family GWK91_RS08290 ENOG4105PFC Transcriptional regulator GWK91_RS08300 ENOG4105E33 succinate dehydrogenase GWK91_RS08310 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GWK91_RS08320 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GWK91_RS08325 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GWK91_RS08330 ENOG4105K63 Thioredoxin GWK91_RS08335 ENOG4105C10 Electron transfer flavoprotein GWK91_RS08340 ENOG4105BZJ Electron transfer flavoprotein GWK91_RS08345 ENOG41060WC Enoyl-CoA hydratase GWK91_RS08350 ENOG4107Z3H Transcriptional regulator, TetR family GWK91_RS08355 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS08365 ENOG4105C98 muts2 protein GWK91_RS08370 ENOG4105DCG PHP domain protein GWK91_RS08380 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GWK91_RS08385 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GWK91_RS08395 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GWK91_RS08400 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GWK91_RS08405 ENOG4108RWN rrna methyltransferase GWK91_RS08415 ENOG4105CN9 Peptidase m42 family protein GWK91_RS08435 ENOG410696E Membrane GWK91_RS08440 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GWK91_RS08445 ENOG4105VJV 50s ribosomal protein L35 GWK91_RS08450 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GWK91_RS08455 ENOG4105C22 threonyL-tRNA synthetase GWK91_RS08460 ENOG4108TDW sporulation protein YtxC GWK91_RS08475 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GWK91_RS08480 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GWK91_RS08485 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GWK91_RS08490 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GWK91_RS08500 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GWK91_RS08505 ENOG4105C2M dna polymerase I GWK91_RS08510 ENOG4105EPW hflc protein GWK91_RS08515 ENOG4107QJR hflk protein GWK91_RS08520 ENOG4105BZU Histidine kinase GWK91_RS08525 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GWK91_RS08535 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GWK91_RS08540 ENOG4108HMX isocitrate dehydrogenase (NADP) GWK91_RS08545 ENOG4105BZN citrate synthase GWK91_RS08550 ENOG4108VMM UPF0756 membrane protein GWK91_RS08555 ENOG4108REF Sporulation integral membrane protein ytvi GWK91_RS08560 ENOG4105FS0 cytoplasmic membrane protein GWK91_RS08565 ENOG4105CA9 Pyruvate kinase GWK91_RS08570 ENOG4105CTQ phosphohexokinase GWK91_RS08575 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GWK91_RS08580 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GWK91_RS08590 ENOG4105C6K Malic enzyme GWK91_RS08595 ENOG4105C0B DNA polymerase III (alpha subunit) GWK91_RS08600 ENOG4105VV2 GWK91_RS08610 ENOG4106EVM GWK91_RS08615 ENOG4105SFS phosphoesterase RecJ domain protein GWK91_RS08635 ENOG4105E8R UPF0173 metal-dependent hydrolase GWK91_RS08640 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GWK91_RS08655 ENOG41087YS Phage shock protein A GWK91_RS08665 ENOG4105DC7 peptidase M24 GWK91_RS08680 ENOG4107YZX Universal stress protein GWK91_RS08685 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GWK91_RS08695 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GWK91_RS08700 ENOG4105KBJ sporulation protein ytfj GWK91_RS08710 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GWK91_RS08715 ENOG4105EFZ amidohydrolase GWK91_RS08725 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GWK91_RS08740 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) GWK91_RS08745 ENOG4105U5Y Transcriptional regulator GWK91_RS08755 ENOG4105BZU Histidine kinase GWK91_RS08760 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GWK91_RS08775 ENOG4105H67 Protein of unknown function (DUF421) GWK91_RS08785 ENOG4105T65 Membrane-associated protein GWK91_RS08790 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GWK91_RS08800 ENOG4105F1V Acetoin utilization protein GWK91_RS08805 ENOG4105W87 Cbs domain GWK91_RS08810 ENOG4105DGU Histone deacetylase GWK91_RS08815 ENOG4106VK6 Flagellar motor protein GWK91_RS08820 ENOG4105E14 MotA TolQ exbB proton channel GWK91_RS08825 ENOG4105ETE Transcriptional regulator (LacI family GWK91_RS08830 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GWK91_RS08835 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GWK91_RS08855 ENOG4105DFU Cell wall formation (By similarity) GWK91_RS08870 ENOG4108VDD TRNA binding domain protein GWK91_RS08875 ENOG4108NKM UPF0354 protein GWK91_RS08885 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GWK91_RS08895 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ GWK91_RS08915 ENOG4105C8F Beta-lactamase domain protein GWK91_RS08920 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GWK91_RS08925 ENOG4108V15 phosphotransferase enzyme family GWK91_RS08945 ENOG4107PBV potassium channel GWK91_RS08950 ENOG4105YW5 deoR family transcriptional regulator GWK91_RS08965 ENOG4105CBX hi0933 family GWK91_RS08970 ENOG4108UT2 hemolysin iii GWK91_RS08990 ENOG41085GJ domain protein GWK91_RS09000 ENOG4108UT2 hemolysin iii GWK91_RS09020 ENOG41085GJ domain protein GWK91_RS09025 ENOG4105C8T Leucyl-tRNA synthetase GWK91_RS09030 ENOG4105CZV ABC transporter GWK91_RS09035 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GWK91_RS09060 ENOG4105E8V Alpha Beta Hydrolase Fold protein GWK91_RS09065 ENOG4108Z0R Transferase GWK91_RS09075 ENOG4105CAQ asparagine synthetase GWK91_RS09080 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GWK91_RS09085 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GWK91_RS09090 ENOG4105D2X ABC transporter substrate-binding protein GWK91_RS09100 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GWK91_RS09125 ENOG4105E0A ABC, transporter GWK91_RS09130 ENOG4105DTQ mandelate racemase muconate lactonizing GWK91_RS09135 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS09140 ENOG4108IPT Naphthoate synthase GWK91_RS09145 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GWK91_RS09150 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GWK91_RS09155 ENOG4105E4F Isochorismate synthase GWK91_RS09160 ENOG4105KA0 thioesterase Superfamily protein GWK91_RS09165 ENOG4108SAX Membrane GWK91_RS09175 ENOG4107PBV potassium channel GWK91_RS09185 ENOG4107QYV phosphohexose isomerase GWK91_RS09190 ENOG4107QW4 alcohol dehydrogenase GWK91_RS09200 ENOG4105C87 Aminotransferase class I and II GWK91_RS09205 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GWK91_RS09215 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GWK91_RS09225 ENOG4107ZYJ bioY protein GWK91_RS09230 ENOG41069ER domain protein GWK91_RS09240 ENOG4105CEP NADH dehydrogenase GWK91_RS09255 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GWK91_RS09260 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GWK91_RS09270 ENOG41083MR nifu domain-containing protein GWK91_RS09275 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GWK91_RS09280 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GWK91_RS09285 ENOG4105C5I Dehydrogenase GWK91_RS09295 ENOG4108W5N phosphatidylglycerophosphatase a GWK91_RS09300 ENOG4105D4U had-superfamily hydrolase, subfamily iia GWK91_RS09320 ENOG4105MMD transcriptional regulator GWK91_RS09325 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GWK91_RS09330 ENOG4105FAA peptidase M23 GWK91_RS09340 ENOG4105C8J )-transporter GWK91_RS09345 ENOG4107S6Z Na H antiporter GWK91_RS09350 ENOG4108YTE sporulation protein YunB GWK91_RS09355 ENOG4105KZD Domain of unknown function (DUF1805) GWK91_RS09360 ENOG4107R8B 5'-nucleotidase GWK91_RS09370 ENOG4105DIW FeS assembly protein SUFB GWK91_RS09375 ENOG4108UNV SUF system FeS assembly protein, NifU family GWK91_RS09385 ENOG4105JRK feS assembly protein SufD GWK91_RS09390 ENOG4105C3K feS assembly ATPase SufC GWK91_RS09395 ENOG4105D01 (LipO)protein GWK91_RS09400 ENOG4108UMI ABC transporter, permease GWK91_RS09405 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GWK91_RS09420 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GWK91_RS09425 ENOG41080E8 Transcriptional regulator, Spx MgsR family GWK91_RS09430 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS09435 ENOG4105CHU acetyl-coa acetyltransferase GWK91_RS09465 ENOG4105FDK ABC transporter GWK91_RS09475 ENOG4107Z6W Protein CrcB homolog GWK91_RS09485 ENOG4105G9B Transcriptional regulator GWK91_RS09490 ENOG4105C28 cystathionine GWK91_RS09500 ENOG4105D6E homoserine dehydrogenase GWK91_RS09510 ENOG4105ENR peptidase, M24 GWK91_RS09545 ENOG4105CJ1 ABC, transporter GWK91_RS09555 ENOG4105FDT acyl-CoA dehydrogenase GWK91_RS09565 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GWK91_RS09570 ENOG4108TGC Acyltransferase GWK91_RS09585 ENOG4108IPW abc transporter atp-binding protein GWK91_RS09590 ENOG4105CM4 permease protein GWK91_RS09595 ENOG4105DHS permease protein GWK91_RS09600 ENOG4105C6Z Gluconate GWK91_RS09610 ENOG4105EA8 2-Nitropropane dioxygenase GWK91_RS09625 ENOG4105H1G trap transporter solute receptor taxi family GWK91_RS09630 ENOG4108MRH transcriptional regulatory protein GWK91_RS09635 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GWK91_RS09640 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GWK91_RS09660 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS09675 ENOG4108UT2 hemolysin iii GWK91_RS09695 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GWK91_RS09715 ENOG4105C59 p-type ATPase GWK91_RS09720 ENOG4105VPX protein, conserved in bacteria GWK91_RS09725 ENOG4105C26 Dehydrogenase GWK91_RS09730 ENOG4105C0A alcohol dehydrogenase GWK91_RS09735 ENOG4108Z7R Chaperone CsaA GWK91_RS09745 ENOG4107Y2X deaminase GWK91_RS09755 ENOG4105BZ8 glutamate synthase GWK91_RS09760 ENOG4105CBC glutamate synthase GWK91_RS09765 ENOG4105C5Q Transcriptional regulator GWK91_RS09780 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GWK91_RS09790 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GWK91_RS09800 ENOG4105XZU Preprotein translocase, subunit SecG GWK91_RS09805 ENOG4105KRI phosphocarrier protein (HPr GWK91_RS09810 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GWK91_RS09825 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GWK91_RS09830 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GWK91_RS09835 ENOG4105CP7 Triose-phosphate isomerase GWK91_RS09840 ENOG4105BZA Phosphoglycerate kinase GWK91_RS09845 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GWK91_RS09860 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWK91_RS09865 ENOG4105WG9 Conserved Protein GWK91_RS09875 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GWK91_RS09880 ENOG4105KRI phosphocarrier protein (HPr GWK91_RS09885 ENOG4105CIE May be required for sporulation (By similarity) GWK91_RS09890 ENOG4105CHW UPF0052 protein GWK91_RS09895 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GWK91_RS09900 ENOG4108Z4K mutator MutT protein GWK91_RS09905 ENOG4105C3M thioredoxin reductase GWK91_RS09915 ENOG4107RVG penicillin-binding protein GWK91_RS09920 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GWK91_RS09925 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GWK91_RS09930 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GWK91_RS09935 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GWK91_RS09940 ENOG4105VDH Dihydroxyacetone kinase GWK91_RS09945 ENOG4108UTZ Dihydroxyacetone kinase GWK91_RS09950 ENOG4105CMT Dihydroxyacetone kinase GWK91_RS09955 ENOG4105DQ6 Transposase GWK91_RS09965 ENOG4108S4C acetyltransferase GWK91_RS09975 ENOG4105HKU nucleoside recognition domain-containing protein GWK91_RS09980 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GWK91_RS09985 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GWK91_RS09990 ENOG41086DT Membrane protein of unknown function GWK91_RS09995 ENOG4108PY7 GWK91_RS10010 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GWK91_RS10015 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GWK91_RS10020 ENOG4105WH1 Two component transcriptional regulator luxr family GWK91_RS10025 ENOG4105CG3 alpha amylase, catalytic region GWK91_RS10030 ENOG4107414 GntR family transcriptional regulator GWK91_RS10035 ENOG4105CG3 alpha amylase, catalytic region GWK91_RS10040 ENOG4105C5Y PTS System GWK91_RS10055 ENOG4105CN1 protease GWK91_RS10060 ENOG4105DR5 peptidase GWK91_RS10065 ENOG4105CRP Part of the ABC transporter FtsEX involved in GWK91_RS10070 ENOG4105CAK Cell division ATP-binding protein ftsE GWK91_RS10090 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GWK91_RS10095 ENOG4105MS2 ribosomal subunit Interface protein GWK91_RS10105 ENOG41069ZS flagellar protein GWK91_RS10110 ENOG4105MQ3 flagellar protein FliS GWK91_RS10115 ENOG41083S7 flagellar protein FlaG GWK91_RS10120 ENOG4105C8Q Methyl-accepting chemotaxis GWK91_RS10140 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GWK91_RS10145 ENOG4107RT6 flagellar hook-associated GWK91_RS10160 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GWK91_RS10165 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) GWK91_RS10170 ENOG4105MKD GWK91_RS10175 ENOG4105DTJ flagellar hook-associated protein GWK91_RS10180 ENOG4105E1Q flagellar hook-associated protein GWK91_RS10195 ENOG4105RU3 GWK91_RS10200 ENOG41081UC Inherit from COG: Competence protein GWK91_RS10225 ENOG4105WH1 Two component transcriptional regulator luxr family GWK91_RS10230 ENOG4105BZU Histidine kinase GWK91_RS10235 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GWK91_RS10250 ENOG4108KGH TRANSCRIPTIONal GWK91_RS10260 ENOG4108UK5 Transposase GWK91_RS10265 ENOG4107QP6 Xylose isomerase domain protein TIM barrel GWK91_RS10270 ENOG4105ETE Transcriptional regulator (LacI family GWK91_RS10275 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GWK91_RS10280 ENOG4105C2J ABC transporter GWK91_RS10285 ENOG4105CNN ABC, transporter GWK91_RS10295 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GWK91_RS10300 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GWK91_RS10310 ENOG4105EQD regulatoR GWK91_RS10315 ENOG4105C2F Histidine kinase GWK91_RS10325 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase GWK91_RS10330 ENOG4105CMR udp-glucose 4-epimerase GWK91_RS10335 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GWK91_RS10345 ENOG4105D17 glycoside hydrolase, family 3 domain protein GWK91_RS10355 ENOG4105C9U ATP-dependent DNA helicase RecQ GWK91_RS10360 ENOG4108MK9 spermidine N(1)-acetyltransferase GWK91_RS10370 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GWK91_RS10375 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GWK91_RS10380 ENOG4105CE4 GlcNAc 6-P deacetylase GWK91_RS10400 ENOG4105C26 Dehydrogenase GWK91_RS10415 ENOG4105D5U fad dependent oxidoreductase GWK91_RS10420 ENOG4105JSC dimethylmenaquinone methyltransferase GWK91_RS10435 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GWK91_RS10440 ENOG41084AG Acylphosphatase GWK91_RS10445 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GWK91_RS10450 ENOG4105CQB FAD linked oxidase domain protein GWK91_RS10455 ENOG4105CHR reductase GWK91_RS10460 ENOG4105CAS nag kinase GWK91_RS10465 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GWK91_RS10470 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GWK91_RS10475 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GWK91_RS10485 ENOG4106ETB IIa component GWK91_RS10500 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GWK91_RS10515 ENOG41081VK Ribonuclease GWK91_RS10535 ENOG4107258 Transcriptional regulator GWK91_RS10545 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GWK91_RS10550 ENOG4105CHU acetyl-coa acetyltransferase GWK91_RS10555 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS10560 ENOG4105E39 Enoyl-CoA hydratase GWK91_RS10565 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GWK91_RS10580 ENOG4107QNJ CoA-transferase subunit B GWK91_RS10585 ENOG4105D6N CoA-transferase, subunit a GWK91_RS10600 ENOG4105C4R Atp-dependent dna helicase GWK91_RS10610 ENOG4107TS3 membrane protein, TerC GWK91_RS10635 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GWK91_RS10645 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GWK91_RS10650 ENOG4105C8Q Methyl-accepting chemotaxis GWK91_RS10660 ENOG4105DRR Transcriptional regulator, GntR family GWK91_RS10665 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS10670 ENOG4108IA2 Sodium pantothenate symporter GWK91_RS10680 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GWK91_RS10685 ENOG4105CNN ABC, transporter GWK91_RS10690 ENOG4105C2J ABC transporter GWK91_RS10695 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GWK91_RS10700 ENOG4108RVA ribokinase GWK91_RS10705 ENOG4105ETE Transcriptional regulator (LacI family GWK91_RS10715 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) GWK91_RS10720 ENOG4105QEK Transcriptional regulator GWK91_RS10725 ENOG4105DFD Na H antiporter GWK91_RS10730 ENOG4105DYB Isoaspartyl dipeptidase GWK91_RS10735 ENOG4108JUB Transcriptional regulator GWK91_RS10740 ENOG4105CZ9 Domain of unknown function (DU1801) GWK91_RS10745 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GWK91_RS10755 ENOG4108RVA ribokinase GWK91_RS10770 ENOG4105DU0 nucleoside hydrolase GWK91_RS10780 ENOG4108RVA ribokinase GWK91_RS10785 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GWK91_RS10790 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GWK91_RS10795 ENOG4105DD7 kinase (PfkB family GWK91_RS10800 ENOG4105DD7 kinase (PfkB family GWK91_RS10815 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS10820 ENOG4105H1G trap transporter solute receptor taxi family GWK91_RS10830 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GWK91_RS10840 ENOG4105CHR reductase GWK91_RS10860 ENOG4105C26 Dehydrogenase GWK91_RS10865 ENOG4105CEY Amp-dependent synthetase and ligase GWK91_RS10870 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS10875 ENOG4105CC9 acyl-Coa dehydrogenase GWK91_RS10885 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GWK91_RS10895 ENOG410900P UPF0336 protein GWK91_RS10915 ENOG4107R7Y intracellular protease Pfpi family GWK91_RS10920 ENOG41061GT Aldolase GWK91_RS10925 ENOG4105D4B ABC, transporter GWK91_RS10930 ENOG4105F5R ABC transporter GWK91_RS10940 ENOG4105C2J ABC transporter GWK91_RS10950 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) GWK91_RS10960 ENOG4107QW4 alcohol dehydrogenase GWK91_RS10965 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GWK91_RS10970 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GWK91_RS10980 ENOG4107RIQ Sulfate adenylate transferase GWK91_RS10985 ENOG4105WH1 Two component transcriptional regulator luxr family GWK91_RS10990 ENOG4105C8Q Methyl-accepting chemotaxis GWK91_RS10995 ENOG4108V3W Chemotaxis protein, CheW GWK91_RS11005 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWK91_RS11110 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GWK91_RS11115 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GWK91_RS11120 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GWK91_RS11140 ENOG4108TMJ glycosyl transferase GWK91_RS11145 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GWK91_RS11155 ENOG4105C5E polysaccharide biosynthesis protein GWK91_RS11170 ENOG4105D3Q Sugar transferase GWK91_RS11175 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GWK91_RS11185 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GWK91_RS11190 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GWK91_RS11195 ENOG4107YJ4 chain length determinant protein GWK91_RS11200 ENOG4105HTX biosynthesis protein GWK91_RS11210 ENOG4108UW5 maltose o-acetyltransferase GWK91_RS11220 ENOG4107EF8 Glycosyl transferase (Group 1 GWK91_RS11225 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GWK91_RS11235 ENOG4108TJN glycosyl transferase group 1 GWK91_RS11255 ENOG4105D3Q Sugar transferase GWK91_RS11260 ENOG4105C6Y Udp-glucose 6-dehydrogenase GWK91_RS11265 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GWK91_RS11285 ENOG4105ESV Glycosyl transferase, family 4 GWK91_RS11290 ENOG4105CKK Glycosyl transferase, family 2 GWK91_RS11320 ENOG4105CJR Integral membrane protein (MviN GWK91_RS11335 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GWK91_RS11370 ENOG4107VDP teichoic acid biosynthesis GWK91_RS11375 ENOG4107SJB teichoic acid biosynthesis GWK91_RS11390 ENOG4105EY8 ABC transporter GWK91_RS11400 ENOG4107SJB teichoic acid biosynthesis GWK91_RS11405 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase GWK91_RS11410 ENOG4107RZX Teichoic acid biosynthesis protein GWK91_RS11415 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GWK91_RS11420 ENOG4105C6Y Udp-glucose 6-dehydrogenase GWK91_RS11430 ENOG4105ESV Glycosyl transferase, family 4 GWK91_RS11455 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GWK91_RS11465 ENOG4105CGA flagellar basal-body rod protein FlgG GWK91_RS11475 ENOG4105DFF Rod shape-determining protein mreb GWK91_RS11480 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GWK91_RS11485 ENOG4105C8P )-transporter GWK91_RS11510 ENOG4105CTB Polyprenyl synthetase GWK91_RS11515 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GWK91_RS11525 ENOG4106778 Protein of unknown function (DUF1146) GWK91_RS11530 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GWK91_RS11535 ENOG4105C8S subunit m GWK91_RS11540 ENOG4105D65 subunit l GWK91_RS11545 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GWK91_RS11555 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GWK91_RS11560 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GWK91_RS11570 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GWK91_RS11575 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GWK91_RS11580 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GWK91_RS11585 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GWK91_RS11590 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GWK91_RS11595 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GWK91_RS11600 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GWK91_RS11605 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GWK91_RS11615 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GWK91_RS11620 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GWK91_RS11625 ENOG41062M3 atp synthase GWK91_RS11635 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GWK91_RS11640 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GWK91_RS11645 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GWK91_RS11650 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GWK91_RS11655 ENOG4108UIC UPF0340 protein GWK91_RS11660 ENOG4108YZG isomerase GWK91_RS11665 ENOG4105C8Q Methyl-accepting chemotaxis GWK91_RS11670 ENOG4107WAU Protein tyrosine phosphatase GWK91_RS11675 ENOG410815N Probably functions as a manganese efflux pump (By similarity) GWK91_RS11680 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GWK91_RS11690 ENOG4108ZXQ stage ii sporulation protein r GWK91_RS11695 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GWK91_RS11700 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GWK91_RS11705 ENOG4107104 thymidine kinase GWK91_RS11710 ENOG41082DI 50s ribosomal protein l31 GWK91_RS11715 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GWK91_RS11720 ENOG4105CBT Fructose-1,6-bisphosphatase GWK91_RS11730 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GWK91_RS11740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GWK91_RS11745 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GWK91_RS11750 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) GWK91_RS11755 ENOG4105DQ6 Transposase GWK91_RS11765 ENOG4105D5P Methylmalonyl-coA mutase GWK91_RS11775 ENOG4105DJT lAO AO transport system ATPase GWK91_RS11780 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS11785 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS11790 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GWK91_RS11800 ENOG4105DF6 Fe-S oxidoreductase GWK91_RS11810 ENOG4105C75 arginyL-tRNA synthetase GWK91_RS11820 ENOG4105BZ4 penicillin-binding protein GWK91_RS11825 ENOG4108XFG YwhD family GWK91_RS11840 ENOG4105DCI Phosphohydrolase GWK91_RS11845 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GWK91_RS11855 ENOG4108IJ2 phosphate acetyltransferase GWK91_RS11860 ENOG4107JTW chlorite dismutase GWK91_RS11865 ENOG4108VKI Cell wall hydrolase GWK91_RS11890 ENOG4105E5Q amino acid AbC transporter GWK91_RS11895 ENOG4106PMH Extracellular solute-binding protein family 3 GWK91_RS11900 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GWK91_RS11905 ENOG4105C1G acyl-Coa dehydrogenase GWK91_RS11910 ENOG4105C26 Dehydrogenase GWK91_RS11930 ENOG4105DQ6 Transposase GWK91_RS11940 ENOG4105C26 Dehydrogenase GWK91_RS11945 ENOG4105C7K acetolactate synthase GWK91_RS11950 ENOG4105CHM Aminotransferase GWK91_RS11955 ENOG4107S6Z Na H antiporter GWK91_RS11960 ENOG4107S6Z Na H antiporter GWK91_RS11980 ENOG4105DWD nucleoside recognition domain protein GWK91_RS11990 ENOG4108X3M OsmC Ohr family protein GWK91_RS11995 ENOG4105K78 MarR family Transcriptional regulator GWK91_RS12005 ENOG4107TS3 membrane protein, TerC GWK91_RS12010 ENOG4105CSU acyl-Coa dehydrogenase GWK91_RS12025 ENOG4105DRP amino acid AbC transporter GWK91_RS12035 ENOG4105CEI nitrite reductase GWK91_RS12045 ENOG4105BZU Histidine kinase GWK91_RS12060 ENOG4105D17 glycoside hydrolase, family 3 domain protein GWK91_RS12065 ENOG4108S4H thioesterase Superfamily protein GWK91_RS12070 ENOG4107MMM Anti-sigma-factor antagonist GWK91_RS12075 ENOG4105EXW epimerase dehydratase GWK91_RS12080 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GWK91_RS12100 ENOG4108QY0 Membrane GWK91_RS12120 ENOG4105VEQ Cold shock protein GWK91_RS12130 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin GWK91_RS12135 ENOG41090WU lipolytic protein G-D-S-L family GWK91_RS12150 ENOG4105C6T cysteine synthase GWK91_RS12160 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWK91_RS12170 ENOG41069DP small acid-soluble spore protein GWK91_RS12185 ENOG4105EEM helicase GWK91_RS12200 ENOG4105ERH Fumarylacetoacetate hydrolase GWK91_RS12205 ENOG4108VJ1 Transcriptional regulator (CarD family GWK91_RS12210 ENOG4105ENR peptidase, M24 GWK91_RS12230 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GWK91_RS12255 ENOG4105CIY formyltetrahydrofolate deformylase GWK91_RS12260 ENOG4105C9U ATP-dependent DNA helicase RecQ GWK91_RS12265 ENOG410605W Major Facilitator GWK91_RS12270 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GWK91_RS12275 ENOG4105BZU Histidine kinase GWK91_RS12280 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GWK91_RS12285 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component GWK91_RS12290 ENOG4108IJ8 ABC transporter GWK91_RS12295 ENOG4105E90 ABC transporter GWK91_RS12300 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GWK91_RS12305 ENOG4108JPW Aminotransferase GWK91_RS12310 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GWK91_RS12320 ENOG4105DFW ABC transporter GWK91_RS12330 ENOG4105CJ1 ABC, transporter GWK91_RS12340 ENOG4108IUX (ABC) transporter GWK91_RS12345 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GWK91_RS12350 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GWK91_RS12365 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GWK91_RS12375 ENOG4105C94 Transporter GWK91_RS12380 ENOG4105DEN Luciferase family GWK91_RS12385 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GWK91_RS12390 ENOG4105C94 Transporter GWK91_RS12395 ENOG4105DUX Transporter GWK91_RS12445 ENOG4105C0H protease GWK91_RS12480 ENOG4105BZU Histidine kinase GWK91_RS12485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GWK91_RS12490 ENOG4108UVJ appr-1-p processing domain protein GWK91_RS12495 ENOG4105D6E homoserine dehydrogenase GWK91_RS12510 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GWK91_RS12530 ENOG4105CVG Homoserine O-transsuccinylase GWK91_RS12535 ENOG4105G3Z GntR family transcriptional regulator GWK91_RS12540 ENOG4105CMG Carbohydrate kinase GWK91_RS12545 ENOG4105C6Z Gluconate GWK91_RS12570 ENOG4105EAM Na Pi-cotransporter GWK91_RS12580 ENOG4108JU6 CBS domain protein GWK91_RS12590 ENOG4105C94 Transporter GWK91_RS12595 ENOG410841Q phosphoesterase PA-phosphatase related protein GWK91_RS12600 ENOG4105DWT malate dehydrogenase (quinone) GWK91_RS12605 ENOG4105CMU LysR family (Transcriptional regulator GWK91_RS12610 ENOG4105C82 Malate synthase GWK91_RS12615 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWK91_RS12625 ENOG4105CH6 catalase GWK91_RS12630 ENOG4105CH6 catalase GWK91_RS12635 ENOG4105CDA abc transporter atp-binding protein GWK91_RS12640 ENOG4105E5Q amino acid AbC transporter GWK91_RS12645 ENOG4105EAB amino acid AbC transporter GWK91_RS12675 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GWK91_RS12685 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GWK91_RS12750 ENOG4105DZR Type I site-specific deoxyribonuclease GWK91_RS12760 ENOG4105CVR type I restriction-modification system GWK91_RS12845 ENOG4105E0M Sulfatase GWK91_RS12850 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GWK91_RS12870 ENOG4105TRT Transcriptional regulator GWK91_RS12875 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWK91_RS12880 ENOG4107RCV ABC transporter, permease GWK91_RS12890 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GWK91_RS12905 ENOG4105HUF DNA protection during starvation protein GWK91_RS12930 ENOG4105D9R oxidoreductase GWK91_RS12935 ENOG4105F3R pts system mannose fructose sorbose family iid GWK91_RS12940 ENOG4105ETZ PTS System GWK91_RS12960 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GWK91_RS12965 ENOG4105C0H protease GWK91_RS12970 ENOG4105Q2H domain protein GWK91_RS12985 ENOG4105BZU Histidine kinase GWK91_RS12990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GWK91_RS12995 ENOG4105DR5 peptidase GWK91_RS13015 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GWK91_RS13035 ENOG4105CDU Replicative dna helicase GWK91_RS13040 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GWK91_RS13045 ENOG4105BZR domain protein GWK91_RS13050 ENOG4108XMW Membrane GWK91_RS13060 ENOG4108UUM single-stranded DNA-binding protein GWK91_RS13065 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GWK91_RS13070 ENOG4105C3G gtp-binding protein GWK91_RS13075 ENOG4105VDK protein, conserved in bacteria GWK91_RS13085 ENOG4108ZDA Sporulation protein YyaC GWK91_RS13095 ENOG4105FA0 parb-like partition protein GWK91_RS13100 ENOG4107QJE Chromosome Partitioning Protein GWK91_RS13105 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) GWK91_RS13110 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GWK91_RS13115 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GWK91_RS13120 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GWK91_RS13130 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GWK91_RS13135 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GWK91_RS13140 ENOG4105VG0 50S ribosomal protein l34 GWK91_RS13145 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GWK91_RS13150 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GWK91_RS13155 ENOG410848D S4 domain protein YaaA GWK91_RS13160 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GWK91_RS13170 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GWK91_RS13175 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GWK91_RS13180 ENOG4105CPI Metal Dependent Phosphohydrolase GWK91_RS13190 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GWK91_RS13205 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GWK91_RS13210 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GWK91_RS13220 ENOG4105ZMH deoxynucleoside kinase GWK91_RS13230 ENOG4105II7 pyrroline-5-carboxylate reductase GWK91_RS13240 ENOG4105J7I hydrolase GWK91_RS13245 ENOG4105E1K spore germination protein GWK91_RS13280 ENOG4105VRS hydrolase family 18 GWK91_RS13285 ENOG4108Z6B deaminase GWK91_RS13295 ENOG4105C6E dna polymerase iii GWK91_RS13300 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GWK91_RS13305 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GWK91_RS13315 ENOG41067KS pro-sigma K processing GWK91_RS13340 ENOG4105CXN decarboxylase GWK91_RS13345 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GWK91_RS13350 ENOG4105X0R protein from nitrogen regulatory protein P-II GWK91_RS13355 ENOG4105XVJ Protein of unknown function (DUF327) GWK91_RS13360 ENOG4105FA2 dna polymerase iii GWK91_RS13365 ENOG4105MA4 psp1 domain protein GWK91_RS13370 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) GWK91_RS13375 ENOG41060K3 Methyltransferase GWK91_RS13380 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GWK91_RS13385 ENOG4105KRN Transcriptional regulator, abrb family GWK91_RS13395 ENOG4105F8V Hydrolase, tatD family GWK91_RS13400 ENOG41069ER domain protein GWK91_RS13405 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GWK91_RS13410 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GWK91_RS13415 ENOG4105XFA sporulation peptidase YabG GWK91_RS13420 ENOG4105W42 Veg protein GWK91_RS13430 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GWK91_RS13435 ENOG4105DFT pur operon repressor GWK91_RS13445 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GWK91_RS13450 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GWK91_RS13455 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GWK91_RS13460 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GWK91_RS13470 ENOG4108JA2 transcriptioN-repair coupling factor GWK91_RS13475 ENOG4108M14 stage v sporulation protein t GWK91_RS13485 ENOG4108IY2 MazG family GWK91_RS13490 ENOG41082I2 s4 domain protein GWK91_RS13495 ENOG4105VYY sporulation protein yabp GWK91_RS13510 ENOG41060GV RNA binding s1 domain protein GWK91_RS13540 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GWK91_RS13545 ENOG4108UGV hypoxanthine phosphoribosyltransferase GWK91_RS13550 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GWK91_RS13555 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GWK91_RS13560 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase GWK91_RS13565 ENOG4105C6T cysteine synthase GWK91_RS13570 ENOG4105EEI dihydropteroate synthase GWK91_RS13575 ENOG4105KRF dihydroneopterin aldolase GWK91_RS13580 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GWK91_RS13590 ENOG4105CRK lysyL-tRNA synthetase GWK91_RS13670 ENOG4105KT7 mgtC SapB transporter GWK91_RS13680 ENOG4108Z0C Uvrb UvrC protein GWK91_RS13685 ENOG41066A3 ATP guanido phosphotransferase GWK91_RS13690 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GWK91_RS13695 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GWK91_RS13700 ENOG4105CTP PilT protein domain protein GWK91_RS13705 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GWK91_RS13710 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GWK91_RS13715 ENOG4105D7W serine acetyltransferase GWK91_RS13720 ENOG4105C8N cysteinyl-tRNA synthetase GWK91_RS13730 ENOG4105C2N RNA methyltransferase TrmH family group 3 GWK91_RS13735 ENOG4105M0M Tetracycline resistance protein GWK91_RS13740 ENOG4105QIV RNA polymerase GWK91_RS13745 ENOG4105WDJ 50S ribosomal protein L33 GWK91_RS13755 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GWK91_RS13765 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GWK91_RS13770 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GWK91_RS13775 ENOG4108VZM 50s ribosomal protein L10 GWK91_RS13780 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GWK91_RS13785 ENOG4107Y49 methyltransferase GWK91_RS13790 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GWK91_RS13795 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GWK91_RS13800 ENOG4105XPM ribosomal protein GWK91_RS13805 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GWK91_RS13810 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GWK91_RS13815 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GWK91_RS13820 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GWK91_RS13825 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GWK91_RS13830 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GWK91_RS13835 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GWK91_RS13840 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GWK91_RS13845 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GWK91_RS13850 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GWK91_RS13855 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GWK91_RS13860 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GWK91_RS13865 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GWK91_RS13870 ENOG41082SA 50s ribosomal protein l29 GWK91_RS13880 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GWK91_RS13890 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GWK91_RS13895 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GWK91_RS13900 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GWK91_RS13905 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GWK91_RS13910 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GWK91_RS13915 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GWK91_RS13920 ENOG4105VPB 50S ribosomal protein L30 GWK91_RS13925 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GWK91_RS13930 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GWK91_RS13935 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GWK91_RS13945 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GWK91_RS13955 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GWK91_RS13960 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GWK91_RS13965 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GWK91_RS13970 ENOG4108ZT0 50S ribosomal protein l17 GWK91_RS13975 ENOG4108JJB ABC transporter GWK91_RS13980 ENOG4108JJB ABC transporter GWK91_RS13985 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GWK91_RS13990 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GWK91_RS14000 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GWK91_RS14005 ENOG4108UJD 30S ribosomal protein S9 GWK91_RS14015 ENOG4105D1F ATP-binding protein GWK91_RS14030 ENOG4108NMV polysaccharide deacetylase GWK91_RS14115 ENOG4105EMN RNA polymerase sigma factor GWK91_RS14125 ENOG4105C8B TIGR00159 family GWK91_RS14130 ENOG4107U5W ybbr family GWK91_RS14135 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GWK91_RS14140 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GWK91_RS14165 ENOG4108RZE Tetr family transcriptional regulator GWK91_RS14175 ENOG4105C2C drug resistance transporter, Bcr CflA GWK91_RS14190 ENOG4107V0Z fmn reductase GWK91_RS14200 ENOG4105KVH Transcriptional regulator GWK91_RS14220 ENOG4105C59 p-type ATPase GWK91_RS14240 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GWK91_RS14245 ENOG4105F27 Major Facilitator GWK91_RS14250 ENOG41080V3 Major Facilitator superfamily GWK91_RS14255 ENOG41090MY MarR family Transcriptional regulator GWK91_RS14265 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GWK91_RS14270 ENOG4105BZW Glycerate kinase GWK91_RS14275 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GWK91_RS14285 ENOG4107SDU Methyl-accepting chemotaxis GWK91_RS14295 ENOG41060D1 Quinol oxidase GWK91_RS14310 ENOG4105E2S oxidase) subunit II GWK91_RS14315 ENOG4105C5H ABC transporter GWK91_RS14325 ENOG4108Q5Y Membrane GWK91_RS14345 ENOG4107TXC Transcriptional regulator GWK91_RS14355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GWK91_RS14360 ENOG41062D9 Histidine kinase GWK91_RS14380 ENOG4105NAA Cytochrome C oxidase, subunit II GWK91_RS14385 ENOG4107RQ2 Cytochrome c oxidase, subunit I GWK91_RS14410 ENOG41067MG lrgb family GWK91_RS14415 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) GWK91_RS14430 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GWK91_RS14435 ENOG4108X4Q Hydrolase GWK91_RS14465 ENOG4105ENE Histidine kinase GWK91_RS14470 ENOG4105WH1 Two component transcriptional regulator luxr family GWK91_RS14485 ENOG41083I7 UPF0145 protein GWK91_RS14490 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GWK91_RS14495 ENOG4108R6K riboflavin synthase, subunit alpha GWK91_RS14500 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GWK91_RS14505 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GWK91_RS14510 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GWK91_RS14530 ENOG4105VEQ Cold shock protein GWK91_RS14535 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) GWK91_RS14540 ENOG4107YB6 acetyltransferase, (GNAT) family GWK91_RS14545 ENOG41090A4 Pterin carbinolamine dehydratase GWK91_RS14560 ENOG41069ER domain protein GWK91_RS14575 ENOG4105CI3 gtp-binding protein typa GWK91_RS14580 ENOG4105CGU Enoyl-CoA hydratase GWK91_RS14590 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) GWK91_RS14595 ENOG4105N67 Proton-coupled thiamine transporter YuaJ GWK91_RS14600 ENOG4105CM2 brancheD-chain amino acid aminotransferase GWK91_RS14605 ENOG4105C01 Dihydroxy-acid dehydratase GWK91_RS14610 ENOG4105C7K acetolactate synthase GWK91_RS14615 ENOG4108ZP8 Acetolactate synthase small subunit GWK91_RS14620 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GWK91_RS14625 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GWK91_RS14630 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GWK91_RS14635 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GWK91_RS14640 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GWK91_RS14645 ENOG4105C7B Threonine dehydratase GWK91_RS14650 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GWK91_RS14655 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GWK91_RS14660 ENOG4105EHG Permease protein GWK91_RS14665 ENOG4105E0A ABC, transporter GWK91_RS14675 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GWK91_RS14680 ENOG4107RU2 Histidinol phosphate phosphatase, HisJ family GWK91_RS14685 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) GWK91_RS14700 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GWK91_RS14705 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GWK91_RS14715 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GWK91_RS14720 ENOG4105CIH Imidazole acetol-phosphate transaminase GWK91_RS14760 ENOG4108RPX mosc domain containing protein GWK91_RS14765 ENOG4105DEN Luciferase family GWK91_RS14810 ENOG4105EPR degv family GWK91_RS14825 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GWK91_RS14830 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GWK91_RS14845 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GWK91_RS14850 ENOG4107MMM Anti-sigma-factor antagonist GWK91_RS14855 ENOG4105FUA antagonist GWK91_RS14860 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GWK91_RS14865 ENOG4107SGM protein serine threonine phosphatase GWK91_RS14875 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GWK91_RS14885 ENOG41064BQ Phosphatase GWK91_RS14900 ENOG410906U SprT-like GWK91_RS14995 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GWK91_RS15000 ENOG4105K8N protein family UPF0079, ATPase GWK91_RS15005 ENOG41072GX Peptidase M22 Glycoprotease GWK91_RS15010 ENOG410801F ribosomal-protein-alanine acetyltransferase GWK91_RS15015 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GWK91_RS15020 ENOG4105C5H ABC transporter GWK91_RS15025 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GWK91_RS15035 ENOG4108TYN CAAX amino terminal protease family protein GWK91_RS15040 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GWK91_RS15045 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GWK91_RS15050 ENOG4105VTR Integrase GWK91_RS15070 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GWK91_RS15080 ENOG4108WUH Transcriptional regulator, TetR family GWK91_RS15090 ENOG4105TRT Transcriptional regulator GWK91_RS15110 ENOG4105DQ6 Transposase GWK91_RS15120 ENOG4105E2A Dehydrogenase GWK91_RS15125 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GWK91_RS15135 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GWK91_RS15225 ENOG4108IUW ABC transporter GWK91_RS15255 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GWK91_RS15270 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GWK91_RS15275 ENOG4105C7N Xanthine uracil vitamin C permease GWK91_RS15290 ENOG4108U5N UPF0316 protein GWK91_RS15300 ENOG4105C83 adenylosuccinate lyase GWK91_RS15310 ENOG4105CPN adenine deaminase GWK91_RS15315 ENOG4108R5T secreted protein GWK91_RS15320 ENOG4105KGF protein, YerC YecD GWK91_RS15325 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GWK91_RS15330 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) GWK91_RS15335 ENOG4105C4R Atp-dependent dna helicase GWK91_RS15340 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GWK91_RS15350 ENOG4105C26 Dehydrogenase GWK91_RS15355 ENOG4105C26 Dehydrogenase GWK91_RS15360 ENOG4105FKZ Methyl-accepting chemotaxis GWK91_RS15365 ENOG4105CK7 Sodium proline symporter GWK91_RS15370 ENOG4107QP3 malate synthase g GWK91_RS15380 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GWK91_RS15385 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWK91_RS15390 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GWK91_RS15395 ENOG4105CBD Diacylglycerol kinase GWK91_RS15400 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GWK91_RS15425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GWK91_RS15430 ENOG4105BZU Histidine kinase GWK91_RS15445 ENOG4105D4A Cell wall formation (By similarity) GWK91_RS15465 ENOG4105JVQ RNA Polymerase GWK91_RS15485 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GWK91_RS15490 ENOG4105C2C drug resistance transporter, Bcr CflA GWK91_RS15495 ENOG4105CK7 Sodium proline symporter GWK91_RS15500 ENOG4105CYW agmatinase GWK91_RS15530 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GWK91_RS15550 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GWK91_RS15555 ENOG4105EE0 oxidoreductase GWK91_RS15595 ENOG4108RAV Conserved protein GWK91_RS15600 ENOG4105DU6 RNA polymerase GWK91_RS15620 ENOG4105BZG amino acid carrier protein GWK91_RS15625 ENOG4105KJF protein tyrosine phosphatase GWK91_RS15635 ENOG4107U9T Pfam:Ribonuclease_BN GWK91_RS15640 ENOG4105C59 p-type ATPase GWK91_RS15645 ENOG4108ISG Major Facilitator GWK91_RS15655 ENOG4105D8X mechanosensitive ion channel GWK91_RS15665 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GWK91_RS15690 ENOG410667J hydrolase GWK91_RS15695 ENOG4105CHR reductase GWK91_RS15700 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GWK91_RS15715 ENOG4105NQG DoxX GWK91_RS15720 ENOG4107VFR oxidoreductase GWK91_RS15730 ENOG4105EYF MMPL domain protein GWK91_RS15740 ENOG4107QIV Cytochrome c biogenesis protein GWK91_RS15745 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GWK91_RS15770 ENOG4105E2A Dehydrogenase GWK91_RS15805 ENOG4107QHF type ii secretion system protein e GWK91_RS15810 ENOG4105CZX twitching motility protein GWK91_RS15815 ENOG4105D7Q type ii secretion system GWK91_RS15825 ENOG4106A3R peptidase GWK91_RS15845 ENOG4105WD1 Membrane GWK91_RS15855 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GWK91_RS15870 ENOG4107SET aldo keto reductase GWK91_RS15900 ENOG4105DA5 (ABC) transporter GWK91_RS15920 ENOG41068JE domain protein GWK91_RS15935 ENOG410902V Modulates RecA activity (By similarity) GWK91_RS15955 ENOG41067AE Membrane-bound metal-dependent hydrolase GWK91_RS15960 ENOG4105CEN a g-specific adenine glycosylase GWK91_RS15970 ENOG4105EVI UPF0374 protein GWK91_RS15975 ENOG4105BZ1 (ABC) transporter GWK91_RS15985 ENOG4108YYC ycei family GWK91_RS16005 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GWK91_RS16010 ENOG4105EMN RNA polymerase sigma factor GWK91_RS16020 ENOG4105CRQ synthase (Component I) GWK91_RS16025 ENOG4105DDQ anthranilate synthase GWK91_RS16030 ENOG4108I0Q anthranilate phosphoribosyltransferase GWK91_RS16065 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GWK91_RS16070 ENOG4105RK9 auxin efflux carrier GWK91_RS16090 ENOG4105C5I Dehydrogenase GWK91_RS16095 ENOG4108WBT adenosyltransferase GWK91_RS16100 ENOG4105G5W regulator Fur family GWK91_RS16200 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GWK91_RS16245 ENOG4105DZR Type I site-specific deoxyribonuclease GWK91_RS16300 ENOG4108IJ7 Glycine betaine GWK91_RS16305 ENOG4108HQS Glycine betaine GWK91_RS16355 ENOG4105BZ4 penicillin-binding protein GWK91_RS16365 ENOG4105G6Z alkaline phosphatase GWK91_RS16375 ENOG4105DIH basic membrane GWK91_RS16380 ENOG4108JQ9 ABC transporter GWK91_RS16385 ENOG4105UIB (ABC) transporter GWK91_RS16405 ENOG4105VFR signal peptidase GWK91_RS16430 ENOG4105C7B Threonine dehydratase GWK91_RS16455 ENOG4105WYW fructose-bisphosphate aldolase GWK91_RS16465 ENOG4108TF4 von Willebrand factor, type A GWK91_RS16480 ENOG4105E0M Sulfatase GWK91_RS16490 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GWK91_RS16495 ENOG4105CZV ABC transporter GWK91_RS16510 ENOG4105JVQ RNA Polymerase