locus-tag	class	description
GWK91_RS00005	COG3383	formate dehydrogenase (NAD+) activity
GWK91_RS00010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWK91_RS00015	COG0702	epimerase
GWK91_RS00020	COG1192	Involved in chromosome partitioning
GWK91_RS00060	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GWK91_RS00065	COG1140	nitrate reductase beta subunit
GWK91_RS00075	COG2181	nitrate reductase activity
GWK91_RS00080	COG0431	NADPH-dependent FMN reductase
GWK91_RS00085	COG0662	Cupin 2, conserved barrel domain protein
GWK91_RS00100	COG1263	PTS System
GWK91_RS00100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK91_RS00105	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GWK91_RS00110	COG1737	Transcriptional regulator
GWK91_RS00155	COG1131	(ABC) transporter
GWK91_RS00165	COG0477	Major facilitator Superfamily
GWK91_RS00170	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GWK91_RS00175	COG3853	Toxic anion resistance protein (TelA)
GWK91_RS00185	COG1473	amidohydrolase
GWK91_RS00195	COG3639	organic phosphonate transmembrane transporter activity
GWK91_RS00200	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWK91_RS00205	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GWK91_RS00210	COG0583	DNA-binding transcription factor activity
GWK91_RS00225	COG1473	amidohydrolase
GWK91_RS00270	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GWK91_RS00275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK91_RS00280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK91_RS00285	COG0492	ferredoxin-NADP+ reductase activity
GWK91_RS00290	COG0300	oxidoreductase activity
GWK91_RS00295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GWK91_RS00305	COG0196	riboflavin kinase activity
GWK91_RS00325	COG3655	Transcriptional regulator
GWK91_RS00335	COG1082	Xylose isomerase domain protein TIM barrel
GWK91_RS00340	COG0322	excinuclease ABC activity
GWK91_RS00370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_RS00375	COG0745	RESPONSE REGULATOR receiver
GWK91_RS00380	COG2205	protein histidine kinase activity
GWK91_RS00390	COG0367	asparagine synthase
GWK91_RS00400	COG3300	MHYT domain
GWK91_RS00400	COG5001	Diguanylate cyclase
GWK91_RS00425	COG1575	Belongs to the MenA family. Type 1 subfamily
GWK91_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS00445	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS00460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWK91_RS00465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWK91_RS00475	COG1131	(ABC) transporter
GWK91_RS00480	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GWK91_RS00510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWK91_RS00525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWK91_RS00530	COG0346	lactoylglutathione lyase activity
GWK91_RS00535	COG0400	carboxylic ester hydrolase activity
GWK91_RS00540	COG0655	NAD(P)H dehydrogenase (quinone) activity
GWK91_RS00545	COG2766	serine protein kinase
GWK91_RS00550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK91_RS00555	COG0765	amino acid transport
GWK91_RS00560	COG1126	abc transporter atp-binding protein
GWK91_RS00570	COG0640	Transcriptional regulator
GWK91_RS00575	COG0567	Dehydrogenase, E1 component
GWK91_RS00580	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK91_RS00585	COG2718	Belongs to the UPF0229 family
GWK91_RS00595	COG2340	Cysteine-rich secretory protein family
GWK91_RS00600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWK91_RS00605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWK91_RS00615	COG0656	L-ascorbic acid biosynthetic process
GWK91_RS00620	COG0288	reversible hydration of carbon dioxide
GWK91_RS00630	COG4841	protein insertion into membrane
GWK91_RS00635	COG1132	(ABC) transporter
GWK91_RS00640	COG1132	(ABC) transporter
GWK91_RS00645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK91_RS00650	COG1191	sigma factor activity
GWK91_RS00675	COG1131	(ABC) transporter
GWK91_RS00680	COG4221	oxidoreductase activity
GWK91_RS00695	COG2719	SpoVR family
GWK91_RS00705	COG1686	Belongs to the peptidase S11 family
GWK91_RS00715	COG0659	secondary active sulfate transmembrane transporter activity
GWK91_RS00720	COG2340	Cysteine-rich secretory protein family
GWK91_RS00730	COG1253	flavin adenine dinucleotide binding
GWK91_RS00735	COG2827	Endonuclease containing a URI domain
GWK91_RS00745	COG0351	phosphomethylpyrimidine kinase
GWK91_RS00750	COG1733	regulation of RNA biosynthetic process
GWK91_RS00785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK91_RS00805	COG1247	-acetyltransferase
GWK91_RS00810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GWK91_RS00820	COG0840	transmembrane signaling receptor activity
GWK91_RS00820	COG5278	phosphoserine phosphatase activity
GWK91_RS00830	COG2270	Major facilitator Superfamily
GWK91_RS00840	COG0114	fumarate hydratase activity
GWK91_RS00865	COG3679	Belongs to the UPF0342 family
GWK91_RS00875	COG4152	abc transporter atp-binding protein
GWK91_RS00880	COG1668	transmembrane transport
GWK91_RS00890	COG0420	3'-5' exonuclease activity
GWK91_RS00895	COG1196	nuclear chromosome segregation
GWK91_RS00900	COG1510	regulation of RNA biosynthetic process
GWK91_RS00905	COG3481	metal-dependent phosphohydrolase, HD sub domain
GWK91_RS00915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWK91_RS00935	COG1846	Transcriptional regulator
GWK91_RS00970	COG4175	Glycine betaine
GWK91_RS00970	COG0517	IMP dehydrogenase activity
GWK91_RS00980	COG2113	Glycine betaine
GWK91_RS00995	COG0537	adenosine 5'-monophosphoramidase activity
GWK91_RS01000	COG1131	(ABC) transporter
GWK91_RS01005	COG4473	ABC transporter
GWK91_RS01015	COG1473	amidohydrolase
GWK91_RS01025	COG4585	Histidine kinase
GWK91_RS01030	COG2197	response regulator
GWK91_RS01035	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWK91_RS01045	COG2329	Antibiotic biosynthesis monooxygenase
GWK91_RS01050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK91_RS01055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWK91_RS01075	COG1234	tRNA 3'-trailer cleavage
GWK91_RS01080	COG0095	Lipoate-protein ligase
GWK91_RS01085	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS01100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK91_RS01100	COG1116	anion transmembrane transporter activity
GWK91_RS01120	COG0398	Pfam SNARE associated Golgi protein
GWK91_RS01130	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GWK91_RS01135	COG1074	ATP-dependent DNA helicase activity
GWK91_RS01140	COG0577	efflux transmembrane transporter activity
GWK91_RS01140	COG1136	(ABC) transporter
GWK91_RS01175	COG2311	Membrane
GWK91_RS01180	COG3695	enzyme binding
GWK91_RS01200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK91_RS01215	COG1307	EDD domain protein, DegV family
GWK91_RS01220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK91_RS01245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWK91_RS01255	COG3639	organic phosphonate transmembrane transporter activity
GWK91_RS01260	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWK91_RS01275	COG0561	phosphatase activity
GWK91_RS01280	COG1073	alpha beta
GWK91_RS01285	COG2151	metal-sulfur cluster biosynthetic enzyme
GWK91_RS01295	COG0535	radical SAM domain protein
GWK91_RS01300	COG1968	undecaprenyl-diphosphatase activity
GWK91_RS01320	COG1744	ABC transporter substrate-binding protein PnrA-like
GWK91_RS01325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK91_RS01330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWK91_RS01350	COG0180	Tryptophanyl-tRNA synthetase
GWK91_RS01385	COG0601	transmembrane transport
GWK91_RS01390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWK91_RS01395	COG0444	Belongs to the ABC transporter superfamily
GWK91_RS01400	COG4608	Belongs to the ABC transporter superfamily
GWK91_RS01415	COG0456	acetyltransferase
GWK91_RS01420	COG1393	Belongs to the ArsC family
GWK91_RS01425	COG0861	Integral membrane protein TerC family
GWK91_RS01435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK91_RS01445	COG1164	Oligoendopeptidase f
GWK91_RS01455	COG2346	COG2346, Truncated hemoglobins
GWK91_RS01460	COG4116	CYTH
GWK91_RS01465	COG2357	RelA SpoT domain protein
GWK91_RS01470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWK91_RS01475	COG0564	pseudouridine synthase activity
GWK91_RS01480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWK91_RS01485	COG0772	Belongs to the SEDS family
GWK91_RS01490	COG2239	Acts as a magnesium transporter
GWK91_RS01515	COG2323	membrane
GWK91_RS01520	COG2153	protein acetylation
GWK91_RS01530	COG2382	esterase
GWK91_RS01535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWK91_RS01545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK91_RS01555	COG4990	cell redox homeostasis
GWK91_RS01560	COG2151	metal-sulfur cluster biosynthetic enzyme
GWK91_RS01580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK91_RS01595	COG1408	metallophosphoesterase
GWK91_RS01600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWK91_RS01605	COG0697	spore germination
GWK91_RS01650	COG0028	Belongs to the TPP enzyme family
GWK91_RS01655	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS01660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK91_RS01675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK91_RS01700	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK91_RS01730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GWK91_RS01735	COG0402	S-adenosylhomocysteine deaminase activity
GWK91_RS01740	COG1131	(ABC) transporter
GWK91_RS01745	COG1725	Transcriptional regulator
GWK91_RS01755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWK91_RS01760	COG2133	pyrroloquinoline quinone binding
GWK91_RS01770	COG0583	DNA-binding transcription factor activity
GWK91_RS01775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK91_RS01785	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK91_RS01790	COG1902	pentaerythritol trinitrate reductase activity
GWK91_RS01805	COG1309	transcriptional regulator
GWK91_RS01810	COG2814	Major facilitator Superfamily
GWK91_RS01815	COG1119	ATPase activity
GWK91_RS01820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWK91_RS01830	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS01865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK91_RS01870	COG1268	BioY protein
GWK91_RS01900	COG1289	transmembrane transporter activity
GWK91_RS01930	COG0697	spore germination
GWK91_RS01935	COG2304	oxidoreductase activity
GWK91_RS01950	COG2113	Glycine betaine
GWK91_RS01955	COG2318	DinB family
GWK91_RS01975	COG2318	DinB family
GWK91_RS01980	COG1742	UPF0060 membrane protein
GWK91_RS02020	COG0697	spore germination
GWK91_RS02025	COG0531	amino acid
GWK91_RS02035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWK91_RS02060	COG0670	Belongs to the BI1 family
GWK91_RS02085	COG0513	Belongs to the DEAD box helicase family
GWK91_RS02090	COG0494	nUDIX hydrolase
GWK91_RS02105	COG0693	protein deglycase activity
GWK91_RS02110	COG3835	regulator
GWK91_RS02115	COG0247	lactate metabolic process
GWK91_RS02120	COG0277	FAD linked oxidase domain protein
GWK91_RS02125	COG2076	Multidrug Resistance protein
GWK91_RS02130	COG2076	Multidrug Resistance protein
GWK91_RS02145	COG0346	lactoylglutathione lyase activity
GWK91_RS02150	COG1301	dicarboxylic acid transport
GWK91_RS02155	COG2391	methyltransferase activity
GWK91_RS02160	COG3118	belongs to the thioredoxin family
GWK91_RS02180	COG0823	Involved in the tonB-independent uptake of proteins
GWK91_RS02180	COG1506	peptidase
GWK91_RS02180	COG4946	Tricorn protease homolog
GWK91_RS02195	COG0697	spore germination
GWK91_RS02205	COG1794	racemase activity, acting on amino acids and derivatives
GWK91_RS02220	COG1404	Belongs to the peptidase S8 family
GWK91_RS02220	COG4412	M6 family metalloprotease domain protein
GWK91_RS02225	COG2201	protein-glutamate methylesterase activity
GWK91_RS02240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK91_RS02245	COG2897	thiosulfate sulfurtransferase activity
GWK91_RS02250	COG1609	Transcriptional regulator
GWK91_RS02255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK91_RS02255	COG1263	PTS System
GWK91_RS02260	COG1621	beta-fructofuranosidase activity
GWK91_RS02265	COG2190	(PTS) system
GWK91_RS02270	COG1940	carbohydrate kinase activity
GWK91_RS02295	COG0436	Aminotransferase
GWK91_RS02300	COG4149	molybdate abc transporter
GWK91_RS02305	COG0328	RNA-DNA hybrid ribonuclease activity
GWK91_RS02325	COG0604	alcohol dehydrogenase
GWK91_RS02330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK91_RS02335	COG0765	amino acid transport
GWK91_RS02355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK91_RS02365	COG1418	mRNA catabolic process
GWK91_RS02370	COG0693	protein deglycase activity
GWK91_RS02375	COG0840	transmembrane signaling receptor activity
GWK91_RS02390	COG0643	Histidine kinase
GWK91_RS02390	COG2198	Histidine kinase
GWK91_RS02395	COG0835	chemotaxis
GWK91_RS02400	COG2201	protein-glutamate methylesterase activity
GWK91_RS02405	COG0840	transmembrane signaling receptor activity
GWK91_RS02420	COG0640	Transcriptional regulator
GWK91_RS02425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GWK91_RS02430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWK91_RS02435	COG1125	glycine betaine transport
GWK91_RS02435	COG0517	IMP dehydrogenase activity
GWK91_RS02440	COG1174	glycine betaine transport
GWK91_RS02445	COG1482	cell wall glycoprotein biosynthetic process
GWK91_RS02455	COG1115	amino acid carrier protein
GWK91_RS02460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWK91_RS02465	COG2233	PERMEase
GWK91_RS02470	COG5505	Protein of unknown function (DUF819)
GWK91_RS02475	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS02505	COG0697	spore germination
GWK91_RS02520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK91_RS02525	COG1388	LysM domain
GWK91_RS02525	COG0791	NLP P60 protein
GWK91_RS02535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK91_RS02560	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GWK91_RS02565	COG0351	phosphomethylpyrimidine kinase
GWK91_RS02570	COG0352	thiamine-phosphate diphosphorylase activity
GWK91_RS02575	COG4667	esterase of the alpha-beta hydrolase superfamily
GWK91_RS02600	COG1937	Protein conserved in bacteria
GWK91_RS02605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_RS02610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_RS02610	COG0425	Belongs to the sulfur carrier protein TusA family
GWK91_RS02615	COG2210	Belongs to the sulfur carrier protein TusA family
GWK91_RS02620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_RS02620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_RS02625	COG0425	Belongs to the sulfur carrier protein TusA family
GWK91_RS02630	COG0730	response to heat
GWK91_RS02640	COG0390	transport system, permease component
GWK91_RS02645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWK91_RS02650	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK91_RS02655	COG1959	2 iron, 2 sulfur cluster binding
GWK91_RS02660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK91_RS02660	COG1017	nitric oxide dioxygenase activity
GWK91_RS02665	COG0431	NADPH-dependent FMN reductase
GWK91_RS02675	COG0385	Bile acid
GWK91_RS02690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK91_RS02700	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS02705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWK91_RS02740	COG5001	Diguanylate cyclase
GWK91_RS02740	COG4251	negative regulation of phosphorylation
GWK91_RS02740	COG3706	GGDEF domain
GWK91_RS02740	COG2203	Gaf domain
GWK91_RS02755	COG5001	Diguanylate cyclase
GWK91_RS02775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK91_RS02805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWK91_RS02850	COG0604	alcohol dehydrogenase
GWK91_RS02855	COG0406	alpha-ribazole phosphatase activity
GWK91_RS02870	COG1073	alpha beta
GWK91_RS02875	COG0716	FMN binding
GWK91_RS02880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK91_RS02885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWK91_RS02900	COG0604	alcohol dehydrogenase
GWK91_RS02905	COG0003	Pfam Anion-transporting ATPase
GWK91_RS02915	COG1966	Carbon starvation protein
GWK91_RS02940	COG2252	PERMEase
GWK91_RS02945	COG1331	Highly conserved protein containing a thioredoxin domain
GWK91_RS02950	COG2002	toxin-antitoxin pair type II binding
GWK91_RS02955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_RS02960	COG0251	oxidation-reduction process
GWK91_RS02965	COG2223	nitrite transmembrane transporter activity
GWK91_RS02970	COG1763	Mo-molybdopterin cofactor biosynthetic process
GWK91_RS02975	COG0314	molybdopterin synthase activity
GWK91_RS02985	COG0315	cyclic pyranopterin monophosphate synthase activity
GWK91_RS02995	COG3290	protein histidine kinase activity
GWK91_RS02995	COG3829	transcription factor binding
GWK91_RS03000	COG1024	Enoyl-CoA hydratase
GWK91_RS03005	COG0511	ligase activity, forming carbon-carbon bonds
GWK91_RS03020	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS03025	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS03030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK91_RS03035	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS03040	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS03040	COG2030	dehydratase
GWK91_RS03050	COG0439	Biotin carboxylase
GWK91_RS03060	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWK91_RS03065	COG0303	'Molybdopterin
GWK91_RS03085	COG2814	Major facilitator Superfamily
GWK91_RS03095	COG0753	catalase activity
GWK91_RS03120	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK91_RS03135	COG1595	DNA-templated transcription, initiation
GWK91_RS03145	COG2323	membrane
GWK91_RS03190	COG0456	acetyltransferase
GWK91_RS03200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWK91_RS03230	COG4989	oxidoreductase activity
GWK91_RS03255	COG3935	DnaD domain protein
GWK91_RS03290	COG4326	sporulation control protein
GWK91_RS03295	COG0386	Belongs to the glutathione peroxidase family
GWK91_RS03315	COG2234	aminopeptidase activity
GWK91_RS03320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWK91_RS03330	COG0741	lytic transglycosylase activity
GWK91_RS03330	COG1196	nuclear chromosome segregation
GWK91_RS03330	COG0739	heme binding
GWK91_RS03335	COG0791	NLP P60 protein
GWK91_RS03340	COG3069	C4-dicarboxylate transmembrane transporter activity
GWK91_RS03370	COG0778	Nitroreductase
GWK91_RS03380	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GWK91_RS03385	COG1793	dna ligase
GWK91_RS03385	COG3285	dna ligase
GWK91_RS03390	COG2226	methyltransferase
GWK91_RS03400	COG2814	Major facilitator Superfamily
GWK91_RS03405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWK91_RS03460	COG2247	cell wall binding repeat
GWK91_RS03460	COG2385	sporulation resulting in formation of a cellular spore
GWK91_RS03470	COG2885	chlorophyll binding
GWK91_RS03470	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GWK91_RS03485	COG0628	permease
GWK91_RS03495	COG5522	Integral membrane protein (intg_mem_TP0381)
GWK91_RS03510	COG0492	ferredoxin-NADP+ reductase activity
GWK91_RS03520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWK91_RS03525	COG5001	Diguanylate cyclase
GWK91_RS03525	COG3300	MHYT domain
GWK91_RS03530	COG0500	methyltransferase
GWK91_RS03535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK91_RS03560	COG0681	Belongs to the peptidase S26 family
GWK91_RS03580	COG0681	Belongs to the peptidase S26 family
GWK91_RS03600	COG0436	Aminotransferase
GWK91_RS03625	COG0393	Putative heavy-metal-binding
GWK91_RS03635	COG1999	signal sequence binding
GWK91_RS03640	COG1408	metallophosphoesterase
GWK91_RS03645	COG1272	protein, Hemolysin III
GWK91_RS03655	COG0517	IMP dehydrogenase activity
GWK91_RS03660	COG2171	N-acyltransferase activity
GWK91_RS03665	COG1473	amidohydrolase
GWK91_RS03675	COG0024	Methionine aminopeptidase
GWK91_RS03680	COG0668	transmembrane transport
GWK91_RS03685	COG0450	alkyl hydroperoxide reductase
GWK91_RS03690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_RS03695	COG5577	PFAM Coat F domain
GWK91_RS03705	COG1132	(ABC) transporter
GWK91_RS03710	COG1132	(ABC) transporter
GWK91_RS03715	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GWK91_RS03720	COG0569	domain protein
GWK91_RS03725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GWK91_RS03735	COG0242	peptide deformylase activity
GWK91_RS03750	COG0022	dehydrogenase e1 component
GWK91_RS03770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK91_RS03780	COG0726	polysaccharide deacetylase
GWK91_RS03800	COG4476	Belongs to the UPF0223 family
GWK91_RS03805	COG4493	Belongs to the UPF0637 family
GWK91_RS03810	COG0483	inositol monophosphate 1-phosphatase activity
GWK91_RS03830	COG4896	Protein conserved in bacteria
GWK91_RS03840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWK91_RS03845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWK91_RS03850	COG2066	Belongs to the glutaminase family
GWK91_RS03855	COG4838	Belongs to the UPF0358 family
GWK91_RS03860	COG0772	Belongs to the SEDS family
GWK91_RS03865	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GWK91_RS03870	COG1612	heme a metabolic process
GWK91_RS03875	COG0109	protoheme IX farnesyltransferase activity
GWK91_RS03880	COG2010	Cytochrome c
GWK91_RS03880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK91_RS03885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK91_RS03895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWK91_RS03900	COG3336	cytochrome c oxidase
GWK91_RS03925	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GWK91_RS03930	COG2340	Cysteine-rich secretory protein family
GWK91_RS03945	COG3679	Belongs to the UPF0342 family
GWK91_RS03950	COG4471	UPF0298 protein
GWK91_RS03960	COG0742	ribosomal rna small subunit methyltransferase
GWK91_RS03970	COG3314	Sporulation integral membrane protein YlbJ
GWK91_RS03975	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK91_RS03980	COG3480	Lon protease (S16) C-terminal proteolytic domain
GWK91_RS03985	COG1323	Belongs to the UPF0348 family
GWK91_RS03990	COG1399	metal-binding, possibly nucleic acid-binding protein
GWK91_RS03995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWK91_RS04000	COG1024	Enoyl-CoA hydratase
GWK91_RS04010	COG0454	-acetyltransferase
GWK91_RS04015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWK91_RS04025	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GWK91_RS04030	COG2001	Belongs to the MraZ family
GWK91_RS04035	COG0275	rRNA processing
GWK91_RS04050	COG0768	penicillin binding
GWK91_RS04055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWK91_RS04060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWK91_RS04065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWK91_RS04070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWK91_RS04075	COG0772	Belongs to the SEDS family
GWK91_RS04080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWK91_RS04085	COG3879	Bacterial protein of unknown function (DUF881)
GWK91_RS04090	COG3879	Bacterial protein of unknown function (DUF881)
GWK91_RS04095	COG3856	small basic protein
GWK91_RS04100	COG0849	cell division
GWK91_RS04105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWK91_RS04120	COG1191	sigma factor activity
GWK91_RS04125	COG1191	sigma factor activity
GWK91_RS04130	COG1873	PFAM PRC-barrel domain
GWK91_RS04140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWK91_RS04145	COG1799	cell septum assembly
GWK91_RS04150	COG0762	integral membrane protein
GWK91_RS04155	COG2302	S4 RNA-binding domain
GWK91_RS04160	COG3599	regulation of cell shape
GWK91_RS04165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWK91_RS04170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWK91_RS04175	COG0564	pseudouridine synthase activity
GWK91_RS04180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GWK91_RS04185	COG2233	PERMEase
GWK91_RS04200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GWK91_RS04205	COG1561	YicC-like family, N-terminal region
GWK91_RS04210	COG2052	Domain of unknown function (DUF370)
GWK91_RS04215	COG0194	GDP metabolic process
GWK91_RS04220	COG1758	RNA polymerase activity
GWK91_RS04225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWK91_RS04230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWK91_RS04235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWK91_RS04240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWK91_RS04240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWK91_RS04245	COG0631	protein serine/threonine phosphatase activity
GWK91_RS04250	COG2815	serine threonine protein kinase
GWK91_RS04250	COG0515	serine threonine protein kinase
GWK91_RS04255	COG1162	GTPase activity
GWK91_RS04260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWK91_RS04265	COG1564	THIamine pyrophosphokinase
GWK91_RS04275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWK91_RS04280	COG1302	Protein conserved in bacteria
GWK91_RS04285	COG1461	Dihydroxyacetone kinase
GWK91_RS04290	COG1760	l-serine dehydratase
GWK91_RS04295	COG1760	l-serine dehydratase
GWK91_RS04300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWK91_RS04305	COG1349	DNA-binding transcription factor activity
GWK91_RS04310	COG0416	fatty acid biosynthetic process
GWK91_RS04315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWK91_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS04325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK91_RS04330	COG0571	ribonuclease III activity
GWK91_RS04335	COG4840	Belongs to the UPF0435 family
GWK91_RS04340	COG1196	nuclear chromosome segregation
GWK91_RS04345	COG0552	protein localization to endoplasmic reticulum
GWK91_RS04350	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GWK91_RS04355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWK91_RS04360	COG0228	four-way junction DNA binding
GWK91_RS04365	COG1837	Belongs to the UPF0109 family
GWK91_RS04375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWK91_RS04380	COG0336	Belongs to the RNA methyltransferase TrmD family
GWK91_RS04385	COG0335	large ribosomal subunit rRNA binding
GWK91_RS04395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWK91_RS04420	COG0045	succinate-CoA ligase (ADP-forming) activity
GWK91_RS04425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWK91_RS04430	COG0758	DNA mediated transformation
GWK91_RS04435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWK91_RS04440	COG4974	Belongs to the 'phage' integrase family
GWK91_RS04445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWK91_RS04450	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWK91_RS04455	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GWK91_RS04460	COG1815	bacterial-type flagellum-dependent cell motility
GWK91_RS04465	COG1558	bacterial-type flagellum-dependent cell motility
GWK91_RS04470	COG1677	Flagellar hook-basal body complex protein FliE
GWK91_RS04475	COG1766	The M ring may be actively involved in energy transduction
GWK91_RS04480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWK91_RS04490	COG1157	protein secretion by the type III secretion system
GWK91_RS04510	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GWK91_RS04520	COG4786	Flagellar basal body rod
GWK91_RS04525	COG1582	Flagellar protein (FlbD)
GWK91_RS04530	COG1580	Controls the rotational direction of flagella during chemotaxis
GWK91_RS04535	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWK91_RS04540	COG1776	CheC inhibitor of MCP methylation
GWK91_RS04540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWK91_RS04545	COG2201	protein-glutamate methylesterase activity
GWK91_RS04550	COG3190	flagellar
GWK91_RS04555	COG1338	Plays a role in the flagellum-specific transport system
GWK91_RS04560	COG1987	bacterial-type flagellum assembly
GWK91_RS04565	COG1684	flagellar biosynthetic protein fliR
GWK91_RS04575	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWK91_RS04580	COG1419	protein localization to endoplasmic reticulum
GWK91_RS04585	COG0455	bacterial-type flagellum organization
GWK91_RS04590	COG2201	protein-glutamate methylesterase activity
GWK91_RS04600	COG1776	CheC inhibitor of MCP methylation
GWK91_RS04605	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GWK91_RS04610	COG1191	sigma factor activity
GWK91_RS04630	COG0052	Belongs to the universal ribosomal protein uS2 family
GWK91_RS04635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWK91_RS04640	COG0528	UMP kinase activity
GWK91_RS04645	COG0233	cytoplasmic translational termination
GWK91_RS04650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWK91_RS04655	COG4589	Belongs to the CDS family
GWK91_RS04665	COG0750	zinc metalloprotease
GWK91_RS04670	COG0442	prolyl-tRNA aminoacylation
GWK91_RS04675	COG2176	DNA-directed DNA polymerase activity
GWK91_RS04685	COG0779	Required for maturation of 30S ribosomal subunits
GWK91_RS04690	COG0195	Participates in both transcription termination and antitermination
GWK91_RS04695	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GWK91_RS04705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWK91_RS04710	COG1550	Protein conserved in bacteria
GWK91_RS04715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWK91_RS04720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWK91_RS04725	COG0196	riboflavin kinase activity
GWK91_RS04730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWK91_RS04735	COG1185	polyribonucleotide nucleotidyltransferase activity
GWK91_RS04745	COG0726	polysaccharide deacetylase
GWK91_RS04750	COG0612	Peptidase, M16
GWK91_RS04755	COG1873	PFAM PRC-barrel domain
GWK91_RS04760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWK91_RS04765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWK91_RS04770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWK91_RS04775	COG0527	aspartate kinase activity
GWK91_RS04780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK91_RS04785	COG0740	serine-type endopeptidase activity
GWK91_RS04795	COG1674	ftsk spoiiie
GWK91_RS04800	COG2188	Transcriptional regulator
GWK91_RS04805	COG0612	Peptidase, M16
GWK91_RS04810	COG0612	Peptidase, M16
GWK91_RS04815	COG0300	oxidoreductase activity
GWK91_RS04830	COG1426	Protein conserved in bacteria
GWK91_RS04835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWK91_RS04840	COG1546	Belongs to the CinA family
GWK91_RS04840	COG1058	Belongs to the CinA family
GWK91_RS04845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWK91_RS04850	COG1418	mRNA catabolic process
GWK91_RS04855	COG1692	metallophosphoesterase
GWK91_RS04860	COG2359	stage V sporulation protein S
GWK91_RS04870	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWK91_RS04870	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWK91_RS04875	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWK91_RS04880	COG1090	epimerase
GWK91_RS04890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWK91_RS04895	COG4550	Control of competence regulator ComK, YlbF/YmcA
GWK91_RS04905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWK91_RS04910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWK91_RS04915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWK91_RS04920	COG1923	regulation of RNA biosynthetic process
GWK91_RS04925	COG0464	growth
GWK91_RS04930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWK91_RS04935	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GWK91_RS04940	COG0789	Transcriptional regulator
GWK91_RS04945	COG0174	glutamine synthetase
GWK91_RS04950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWK91_RS04955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWK91_RS04960	COG4224	UPF0291 protein
GWK91_RS04965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWK91_RS04975	COG3763	UPF0154 protein
GWK91_RS04980	COG0785	Cytochrome C biogenesis protein
GWK91_RS04985	COG2111	Na H antiporter
GWK91_RS04990	COG2201	protein-glutamate methylesterase activity
GWK91_RS04995	COG4846	Membrane protein involved in cytochrome C biogenesis
GWK91_RS05015	COG4191	Histidine kinase
GWK91_RS05040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GWK91_RS05045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_RS05065	COG0824	Thioesterase
GWK91_RS05075	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWK91_RS05080	COG1469	GTP cyclohydrolase I activity
GWK91_RS05085	COG2843	Capsule synthesis protein
GWK91_RS05090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWK91_RS05095	COG1832	CoA-binding protein
GWK91_RS05100	COG0187	DNA topoisomerase II activity
GWK91_RS05105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWK91_RS05115	COG1309	transcriptional regulator
GWK91_RS05120	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS05125	COG0511	ligase activity, forming carbon-carbon bonds
GWK91_RS05130	COG1024	Enoyl-CoA hydratase
GWK91_RS05135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK91_RS05140	COG2226	methyltransferase
GWK91_RS05150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK91_RS05155	COG0456	acetyltransferase
GWK91_RS05160	COG2814	Major facilitator Superfamily
GWK91_RS05165	COG3383	formate dehydrogenase (NAD+) activity
GWK91_RS05180	COG2116	formate transmembrane transporter activity
GWK91_RS05190	COG1404	Belongs to the peptidase S8 family
GWK91_RS05210	COG0326	Molecular chaperone. Has ATPase activity
GWK91_RS05230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWK91_RS05235	COG2022	thiamine diphosphate biosynthetic process
GWK91_RS05245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK91_RS05250	COG0352	thiamine-phosphate diphosphorylase activity
GWK91_RS05255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GWK91_RS05260	COG0582	viral genome integration into host DNA
GWK91_RS05280	COG0456	acetyltransferase
GWK91_RS05280	COG1214	PFAM Peptidase M22, glycoprotease
GWK91_RS05290	COG3192	ethanolamine utilization protein
GWK91_RS05295	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWK91_RS05300	COG3773	Cell wall hydrolase
GWK91_RS05315	COG2059	Chromate
GWK91_RS05320	COG2059	Chromate
GWK91_RS05330	COG0427	acetyl-CoA hydrolase
GWK91_RS05335	COG3279	Response regulator of the LytR AlgR family
GWK91_RS05340	COG2124	cytochrome p450
GWK91_RS05365	COG0542	response to heat
GWK91_RS05370	COG2860	membrane
GWK91_RS05390	COG0346	lactoylglutathione lyase activity
GWK91_RS05405	COG0456	acetyltransferase
GWK91_RS05415	COG1252	NADH dehydrogenase
GWK91_RS05420	COG0737	Belongs to the 5'-nucleotidase family
GWK91_RS05420	COG1525	nuclease
GWK91_RS05420	COG4085	toxin activity
GWK91_RS05450	COG1024	Enoyl-CoA hydratase
GWK91_RS05455	COG2045	Belongs to the ComB family
GWK91_RS05465	COG0183	Belongs to the thiolase family
GWK91_RS05470	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS05490	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS05495	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS05505	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS05525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWK91_RS05525	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWK91_RS05535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWK91_RS05560	COG2027	D-alanyl-D-alanine carboxypeptidase
GWK91_RS05565	COG2996	Protein conserved in bacteria
GWK91_RS05585	COG0564	pseudouridine synthase activity
GWK91_RS05610	COG2839	Protein conserved in bacteria
GWK91_RS05630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK91_RS05640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK91_RS05645	COG2323	membrane
GWK91_RS05650	COG2181	nitrate reductase activity
GWK91_RS05660	COG1140	nitrate reductase beta subunit
GWK91_RS05665	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GWK91_RS05685	COG4191	Histidine kinase
GWK91_RS05710	COG0626	cystathionine gamma-synthase activity
GWK91_RS05715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK91_RS05720	COG1854	S-ribosylhomocysteine lyase activity
GWK91_RS05725	COG2226	methyltransferase
GWK91_RS05735	COG0735	belongs to the Fur family
GWK91_RS05740	COG0753	catalase activity
GWK91_RS05745	COG0714	Associated with various cellular activities
GWK91_RS05750	COG4548	von Willebrand factor, type A
GWK91_RS05765	COG4294	response to UV
GWK91_RS05775	COG1737	Transcriptional regulator
GWK91_RS05780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWK91_RS05785	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWK91_RS05790	COG0746	molybdenum cofactor guanylyltransferase activity
GWK91_RS05795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK91_RS05800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWK91_RS05810	COG2181	nitrate reductase activity
GWK91_RS05815	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GWK91_RS05820	COG1140	nitrate reductase beta subunit
GWK91_RS05825	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GWK91_RS05845	COG0455	bacterial-type flagellum organization
GWK91_RS05885	COG5002	protein histidine kinase activity
GWK91_RS05890	COG2205	protein histidine kinase activity
GWK91_RS05895	COG0488	(ABC) transporter
GWK91_RS05900	COG0513	Belongs to the DEAD box helicase family
GWK91_RS05905	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GWK91_RS05910	COG3191	aminopeptidase activity
GWK91_RS05935	COG1489	DNA binding
GWK91_RS05945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWK91_RS05945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWK91_RS05955	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWK91_RS05960	COG2084	Dehydrogenase
GWK91_RS05975	COG0419	ATPase involved in DNA repair
GWK91_RS05980	COG0420	3'-5' exonuclease activity
GWK91_RS05995	COG4479	Belongs to the UPF0346 family
GWK91_RS06000	COG0805	protein transport
GWK91_RS06005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWK91_RS06010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWK91_RS06020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWK91_RS06025	COG0791	NLP P60 protein
GWK91_RS06025	COG1388	LysM domain
GWK91_RS06030	COG1418	mRNA catabolic process
GWK91_RS06035	COG1801	Protein of unknown function DUF72
GWK91_RS06045	COG1278	Cold shock
GWK91_RS06050	COG0741	lytic transglycosylase activity
GWK91_RS06055	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWK91_RS06060	COG1755	Isoprenylcysteine carboxyl methyltransferase
GWK91_RS06065	COG3424	synthase
GWK91_RS06070	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS06080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK91_RS06085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK91_RS06090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWK91_RS06095	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK91_RS06100	COG0116	Belongs to the methyltransferase superfamily
GWK91_RS06110	COG3599	regulation of cell shape
GWK91_RS06115	COG4474	Belongs to the UPF0398 family
GWK91_RS06125	COG0295	cytidine deaminase activity
GWK91_RS06145	COG3331	DNA recombination
GWK91_RS06150	COG4499	WXG100 protein secretion system (Wss), protein YukC
GWK91_RS06150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK91_RS06155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWK91_RS06160	COG3935	DnaD domain protein
GWK91_RS06165	COG0017	Asparaginyl-tRNA synthetase
GWK91_RS06170	COG0436	Aminotransferase
GWK91_RS06190	COG1199	ATP-dependent helicase activity
GWK91_RS06190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWK91_RS06195	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GWK91_RS06200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWK91_RS06205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWK91_RS06215	COG0617	tRNA 3'-terminal CCA addition
GWK91_RS06220	COG0438	transferase activity, transferring glycosyl groups
GWK91_RS06225	COG1803	Methylglyoxal synthase
GWK91_RS06230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWK91_RS06235	COG1694	Mazg nucleotide pyrophosphohydrolase
GWK91_RS06240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK91_RS06245	COG2738	Putative neutral zinc metallopeptidase
GWK91_RS06255	COG4347	Protein of unknown function (DUF1405)
GWK91_RS06265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWK91_RS06285	COG0457	Tetratricopeptide repeat
GWK91_RS06295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWK91_RS06300	COG0287	Prephenate dehydrogenase
GWK91_RS06305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWK91_RS06310	COG4401	Chorismate mutase type I
GWK91_RS06315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWK91_RS06320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWK91_RS06325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWK91_RS06330	COG0105	UTP biosynthetic process
GWK91_RS06335	COG0142	geranyltranstransferase activity
GWK91_RS06340	COG2226	methyltransferase
GWK91_RS06360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GWK91_RS06380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWK91_RS06385	COG1160	GTP binding
GWK91_RS06395	COG1304	FMN binding
GWK91_RS06400	COG0539	negative regulation of cytoplasmic translation
GWK91_RS06405	COG0204	Acyl-transferase
GWK91_RS06410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWK91_RS06425	COG2959	enzyme of heme biosynthesis
GWK91_RS06430	COG3409	Peptidoglycan-binding domain 1 protein
GWK91_RS06430	COG3773	Cell wall hydrolase
GWK91_RS06435	COG2339	peptidase activity
GWK91_RS06445	COG0492	ferredoxin-NADP+ reductase activity
GWK91_RS06450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK91_RS06455	COG4862	establishment of competence for transformation
GWK91_RS06460	COG1408	metallophosphoesterase
GWK91_RS06480	COG0514	ATP-dependent DNA helicase (RecQ)
GWK91_RS06485	COG4955	Helix-turn-helix domain
GWK91_RS06500	COG1595	DNA-templated transcription, initiation
GWK91_RS06505	COG5002	protein histidine kinase activity
GWK91_RS06510	COG0745	RESPONSE REGULATOR receiver
GWK91_RS06515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWK91_RS06520	COG1333	cytochrome c biogenesis protein
GWK91_RS06525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_RS06530	COG1187	pseudouridine synthase activity
GWK91_RS06535	COG0700	Nucleoside recognition
GWK91_RS06540	COG2715	membrane protein required for spore maturation
GWK91_RS06545	COG1686	Belongs to the peptidase S11 family
GWK91_RS06550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWK91_RS06560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWK91_RS06565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GWK91_RS06575	COG1547	Domain of unknown function (DUF309)
GWK91_RS06590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWK91_RS06595	COG0019	diaminopimelate decarboxylase activity
GWK91_RS06600	COG0697	spore germination
GWK91_RS06610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK91_RS06640	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK91_RS06645	COG1686	Belongs to the peptidase S11 family
GWK91_RS06650	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GWK91_RS06660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GWK91_RS06665	COG4974	Belongs to the 'phage' integrase family
GWK91_RS06675	COG0735	belongs to the Fur family
GWK91_RS06680	COG1300	Membrane
GWK91_RS06685	COG1379	DNA repair
GWK91_RS06690	COG0494	nUDIX hydrolase
GWK91_RS06695	COG0667	Aldo Keto reductase
GWK91_RS06710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWK91_RS06715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWK91_RS06720	COG1072	(Pantothenic acid kinase))
GWK91_RS06725	COG0300	oxidoreductase activity
GWK91_RS06730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_RS06735	COG4187	Peptidase family M20/M25/M40
GWK91_RS06740	COG0584	glycerophosphoryl diester phosphodiesterase
GWK91_RS06745	COG1902	pentaerythritol trinitrate reductase activity
GWK91_RS06755	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS06760	COG2252	PERMEase
GWK91_RS06765	COG2226	methyltransferase
GWK91_RS06770	COG0175	sulfate reduction
GWK91_RS06785	COG4166	transmembrane transport
GWK91_RS06795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWK91_RS06800	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWK91_RS06805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK91_RS06810	COG0346	lactoylglutathione lyase activity
GWK91_RS06815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK91_RS06815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK91_RS06820	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS06825	COG2070	2-Nitropropane dioxygenase
GWK91_RS06830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK91_RS06835	COG0183	Belongs to the thiolase family
GWK91_RS06840	COG1309	transcriptional regulator
GWK91_RS06850	COG4129	membrane
GWK91_RS06865	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK91_RS06870	COG0022	dehydrogenase e1 component
GWK91_RS06875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWK91_RS06880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK91_RS06895	COG0280	phosphate acetyltransferase
GWK91_RS06900	COG3290	protein histidine kinase activity
GWK91_RS06900	COG3829	transcription factor binding
GWK91_RS06910	COG0527	aspartate kinase activity
GWK91_RS06940	COG2197	response regulator
GWK91_RS06945	COG1022	Amp-dependent synthetase and ligase
GWK91_RS06960	COG0183	Belongs to the thiolase family
GWK91_RS06965	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS06970	COG1024	Enoyl-CoA hydratase
GWK91_RS06975	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS06990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_RS07000	COG0750	zinc metalloprotease
GWK91_RS07005	COG0497	DNA recombination
GWK91_RS07010	COG1438	arginine binding
GWK91_RS07015	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GWK91_RS07020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWK91_RS07030	COG0142	geranyltranstransferase activity
GWK91_RS07035	COG1722	exodeoxyribonuclease VII activity
GWK91_RS07045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWK91_RS07050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWK91_RS07055	COG1302	Protein conserved in bacteria
GWK91_RS07060	COG0439	Biotin carboxylase
GWK91_RS07065	COG0511	ligase activity, forming carbon-carbon bonds
GWK91_RS07105	COG3854	ATPases associated with a variety of cellular activities
GWK91_RS07110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWK91_RS07115	COG0006	proline dipeptidase activity
GWK91_RS07120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWK91_RS07135	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK91_RS07140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK91_RS07145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_RS07155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWK91_RS07160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWK91_RS07165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWK91_RS07185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWK91_RS07190	COG1459	type II secretion system
GWK91_RS07195	COG4537	Required for transformation and DNA binding
GWK91_RS07240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_RS07250	COG1368	sulfuric ester hydrolase activity
GWK91_RS07255	COG1940	carbohydrate kinase activity
GWK91_RS07260	COG4483	Protein conserved in bacteria
GWK91_RS07265	COG0697	spore germination
GWK91_RS07275	COG0705	Rhomboid family
GWK91_RS07275	COG0457	Tetratricopeptide repeat
GWK91_RS07285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWK91_RS07305	COG0704	Plays a role in the regulation of phosphate uptake
GWK91_RS07315	COG0581	inorganic phosphate transmembrane transporter activity
GWK91_RS07320	COG0573	inorganic phosphate transmembrane transporter activity
GWK91_RS07325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GWK91_RS07335	COG0477	Major facilitator Superfamily
GWK91_RS07375	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWK91_RS07390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GWK91_RS07395	COG4709	membrane
GWK91_RS07405	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GWK91_RS07410	COG0513	Belongs to the DEAD box helicase family
GWK91_RS07415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWK91_RS07420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWK91_RS07425	COG2384	SAM-dependent methyltransferase
GWK91_RS07440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWK91_RS07445	COG0358	DNA primase activity
GWK91_RS07450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GWK91_RS07455	COG0517	IMP dehydrogenase activity
GWK91_RS07460	COG1381	Involved in DNA repair and RecF pathway recombination
GWK91_RS07470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWK91_RS07475	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWK91_RS07480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWK91_RS07485	COG1480	7TM receptor with intracellular HD hydrolase
GWK91_RS07490	COG1702	phosphate starvation-inducible protein PhoH
GWK91_RS07495	COG0561	phosphatase activity
GWK91_RS07510	COG4864	UPF0365 protein
GWK91_RS07515	COG1030	water channel activity
GWK91_RS07520	COG1610	YqeY-like protein
GWK91_RS07525	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWK91_RS07530	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWK91_RS07535	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWK91_RS07560	COG0642	Histidine kinase
GWK91_RS07565	COG0745	RESPONSE REGULATOR receiver
GWK91_RS07570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWK91_RS07575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWK91_RS07580	COG2264	protein methyltransferase activity
GWK91_RS07585	COG0484	heat shock protein binding
GWK91_RS07590	COG0443	Heat shock 70 kDa protein
GWK91_RS07595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWK91_RS07600	COG1420	regulation of RNA biosynthetic process
GWK91_RS07605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWK91_RS07610	COG0481	GTPase activity
GWK91_RS07620	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GWK91_RS07625	COG0268	Binds directly to 16S ribosomal RNA
GWK91_RS07630	COG1466	dna polymerase III delta subunit
GWK91_RS07640	COG0658	competence protein
GWK91_RS07640	COG2333	competence protein COMEC
GWK91_RS07645	COG2131	deaminase
GWK91_RS07650	COG1596	polysaccharide export
GWK91_RS07650	COG1555	photosystem II stabilization
GWK91_RS07655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWK91_RS07660	COG1247	-acetyltransferase
GWK91_RS07665	COG2226	methyltransferase
GWK91_RS07670	COG0799	negative regulation of ribosome biogenesis
GWK91_RS07675	COG1713	HD superfamily hydrolase involved in NAD metabolism
GWK91_RS07680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWK91_RS07685	COG1534	Rna-binding protein
GWK91_RS07690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWK91_RS07695	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWK91_RS07700	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GWK91_RS07710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK91_RS07710	COG2111	Na H antiporter
GWK91_RS07715	COG1006	Multisubunit Na H antiporter MnhC subunit
GWK91_RS07720	COG0651	ATP synthesis coupled electron transport
GWK91_RS07730	COG2212	antiporter activity
GWK91_RS07750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWK91_RS07765	COG0768	penicillin binding
GWK91_RS07770	COG0768	penicillin binding
GWK91_RS07775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWK91_RS07780	COG0572	uridine kinase
GWK91_RS07785	COG4122	O-methyltransferase activity
GWK91_RS07790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWK91_RS07795	COG3906	Belongs to the UPF0473 family
GWK91_RS07800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWK91_RS07805	COG4472	Bacterial protein of unknown function (DUF965)
GWK91_RS07810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWK91_RS07815	COG0628	permease
GWK91_RS07825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWK91_RS07835	COG0482	sulfurtransferase activity
GWK91_RS07840	COG1104	cysteine desulfurase activity
GWK91_RS07845	COG1959	2 iron, 2 sulfur cluster binding
GWK91_RS07850	COG2364	Membrane
GWK91_RS07855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWK91_RS07865	COG0137	argininosuccinate synthase activity
GWK91_RS07870	COG0165	Argininosuccinate lyase
GWK91_RS07875	COG0505	Belongs to the CarA family
GWK91_RS07880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWK91_RS07885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWK91_RS07895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWK91_RS07900	COG0124	histidyl-tRNA synthetase
GWK91_RS07910	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK91_RS07915	COG1490	D-aminoacyl-tRNA deacylase activity
GWK91_RS07920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWK91_RS07925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWK91_RS07930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GWK91_RS07930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWK91_RS07935	COG5416	Lipopolysaccharide assembly protein A domain
GWK91_RS07940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWK91_RS07940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWK91_RS07950	COG2244	polysaccharide biosynthetic process
GWK91_RS07955	COG2323	membrane
GWK91_RS07960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GWK91_RS07970	COG1862	Preprotein translocase
GWK91_RS07975	COG0343	queuine tRNA-ribosyltransferase activity
GWK91_RS07980	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWK91_RS07990	COG2255	four-way junction helicase activity
GWK91_RS07995	COG0632	four-way junction helicase activity
GWK91_RS08005	COG0217	transcriptional regulatory protein
GWK91_RS08015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWK91_RS08020	COG1388	LysM domain
GWK91_RS08025	COG0077	Prephenate dehydratase
GWK91_RS08030	COG4492	Belongs to the UPF0735 family
GWK91_RS08035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWK91_RS08045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWK91_RS08050	COG2868	ribosomal protein
GWK91_RS08055	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWK91_RS08060	COG1530	ribonuclease E activity
GWK91_RS08065	COG1994	Peptidase M50
GWK91_RS08075	COG0347	Belongs to the P(II) protein family
GWK91_RS08080	COG0004	ammonium transporteR
GWK91_RS08085	COG0367	asparagine synthase
GWK91_RS08090	COG2894	cell division
GWK91_RS08095	COG0850	regulation of cytokinetic process
GWK91_RS08110	COG1077	Cell shape determining protein MreB Mrl
GWK91_RS08115	COG2003	Belongs to the UPF0758 family
GWK91_RS08120	COG0424	maF-like protein
GWK91_RS08135	COG3706	GGDEF domain
GWK91_RS08140	COG0285	dihydrofolate synthase activity
GWK91_RS08145	COG0525	valine-tRNA ligase activity
GWK91_RS08160	COG1388	LysM domain
GWK91_RS08160	COG1388	LysM domain
GWK91_RS08165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWK91_RS08170	COG0113	porphobilinogen synthase activity
GWK91_RS08175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWK91_RS08175	COG1587	Uroporphyrinogen-III synthase
GWK91_RS08180	COG0181	hydroxymethylbilane synthase activity
GWK91_RS08185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWK91_RS08190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWK91_RS08200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWK91_RS08205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWK91_RS08210	COG1067	ATP-dependent peptidase activity
GWK91_RS08210	COG0470	DNA polymerase III
GWK91_RS08215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWK91_RS08220	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWK91_RS08265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWK91_RS08270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWK91_RS08275	COG5401	PFAM Sporulation and spore germination
GWK91_RS08285	COG1846	Transcriptional regulator
GWK91_RS08290	COG2197	response regulator
GWK91_RS08295	COG0824	Thioesterase
GWK91_RS08300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWK91_RS08305	COG1053	succinate dehydrogenase
GWK91_RS08310	COG2009	succinate dehydrogenase
GWK91_RS08315	COG1719	4-vinyl reductase, 4VR
GWK91_RS08320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWK91_RS08325	COG0322	excinuclease ABC activity
GWK91_RS08330	COG3118	belongs to the thioredoxin family
GWK91_RS08335	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GWK91_RS08340	COG2086	electron transfer activity
GWK91_RS08345	COG1024	Enoyl-CoA hydratase
GWK91_RS08350	COG1309	transcriptional regulator
GWK91_RS08355	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS08360	COG3766	membrane
GWK91_RS08365	COG1193	negative regulation of DNA recombination
GWK91_RS08370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWK91_RS08370	COG1796	DNA polymerase
GWK91_RS08375	COG1286	toxin biosynthetic process
GWK91_RS08380	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GWK91_RS08385	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWK91_RS08395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK91_RS08395	COG0072	phenylalanine-tRNA ligase activity
GWK91_RS08400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWK91_RS08405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWK91_RS08415	COG1363	Peptidase, m42
GWK91_RS08430	COG0398	Pfam SNARE associated Golgi protein
GWK91_RS08435	COG3326	Membrane
GWK91_RS08440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWK91_RS08445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWK91_RS08450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWK91_RS08455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWK91_RS08465	COG1484	DNA-dependent DNA replication
GWK91_RS08470	COG3611	Membrane attachment protein
GWK91_RS08475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWK91_RS08480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GWK91_RS08485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWK91_RS08490	COG0237	dephospho-CoA kinase activity
GWK91_RS08495	COG1971	Probably functions as a manganese efflux pump
GWK91_RS08500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWK91_RS08505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK91_RS08505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK91_RS08510	COG0330	HflC and HflK could
GWK91_RS08515	COG0330	HflC and HflK could
GWK91_RS08520	COG5002	protein histidine kinase activity
GWK91_RS08525	COG0745	RESPONSE REGULATOR receiver
GWK91_RS08535	COG0039	L-malate dehydrogenase activity
GWK91_RS08540	COG0538	isocitrate dehydrogenase activity
GWK91_RS08545	COG0372	Belongs to the citrate synthase family
GWK91_RS08550	COG2707	UPF0756 membrane protein
GWK91_RS08555	COG0628	permease
GWK91_RS08560	COG3030	protein affecting phage T7 exclusion by the F plasmid
GWK91_RS08575	COG0825	malonyl-CoA metabolic process
GWK91_RS08580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWK91_RS08590	COG0281	malic enzyme
GWK91_RS08595	COG0587	DNA-directed DNA polymerase activity
GWK91_RS08615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWK91_RS08625	COG4109	DRTGG domain
GWK91_RS08635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWK91_RS08640	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GWK91_RS08645	COG3766	membrane
GWK91_RS08655	COG1842	Phage shock protein A
GWK91_RS08665	COG0006	proline dipeptidase activity
GWK91_RS08675	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS08680	COG0589	response to stress
GWK91_RS08685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWK91_RS08690	COG0827	DNA restriction-modification system
GWK91_RS08695	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GWK91_RS08700	COG3874	Sporulation protein YtfJ
GWK91_RS08710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWK91_RS08715	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GWK91_RS08725	COG0301	tRNA thio-modification
GWK91_RS08730	COG1104	cysteine desulfurase activity
GWK91_RS08740	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GWK91_RS08745	COG1309	transcriptional regulator
GWK91_RS08750	COG1956	GAF domain-containing protein
GWK91_RS08755	COG2199	diguanylate cyclase activity
GWK91_RS08755	COG2203	Gaf domain
GWK91_RS08760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWK91_RS08775	COG2323	membrane
GWK91_RS08785	COG4640	response to antibiotic
GWK91_RS08790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWK91_RS08800	COG0454	-acetyltransferase
GWK91_RS08805	COG0517	IMP dehydrogenase activity
GWK91_RS08810	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWK91_RS08830	COG1605	Chorismate mutase
GWK91_RS08830	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GWK91_RS08840	COG3118	belongs to the thioredoxin family
GWK91_RS08845	COG4980	gas vesicle protein
GWK91_RS08855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWK91_RS08865	COG1674	ftsk spoiiie
GWK91_RS08870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK91_RS08875	COG4848	Belongs to the UPF0354 family
GWK91_RS08880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_RS08885	COG0840	transmembrane signaling receptor activity
GWK91_RS08900	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GWK91_RS08905	COG1363	Peptidase, m42
GWK91_RS08915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK91_RS08920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWK91_RS08925	COG0510	thiamine kinase activity
GWK91_RS08930	COG1597	lipid kinase activity
GWK91_RS08945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWK91_RS08950	COG1349	DNA-binding transcription factor activity
GWK91_RS08955	COG1187	pseudouridine synthase activity
GWK91_RS08960	COG2244	polysaccharide biosynthetic process
GWK91_RS08965	COG2081	HI0933 family
GWK91_RS08970	COG1272	protein, Hemolysin III
GWK91_RS08990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_RS09000	COG1272	protein, Hemolysin III
GWK91_RS09020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK91_RS09025	COG0495	leucyl-tRNA aminoacylation
GWK91_RS09030	COG1131	(ABC) transporter
GWK91_RS09035	COG1725	Transcriptional regulator
GWK91_RS09050	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GWK91_RS09060	COG2267	carboxylic ester hydrolase activity
GWK91_RS09065	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWK91_RS09070	COG4990	cell redox homeostasis
GWK91_RS09075	COG0367	asparagine synthase
GWK91_RS09080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GWK91_RS09085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GWK91_RS09090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK91_RS09095	COG1116	anion transmembrane transporter activity
GWK91_RS09100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK91_RS09105	COG0494	nUDIX hydrolase
GWK91_RS09125	COG1120	ATPase activity
GWK91_RS09130	COG4948	Mandelate Racemase Muconate Lactonizing
GWK91_RS09135	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS09140	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GWK91_RS09145	COG0596	Alpha beta hydrolase
GWK91_RS09150	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GWK91_RS09155	COG1169	isochorismate synthase
GWK91_RS09160	COG2050	protein possibly involved in aromatic compounds catabolism
GWK91_RS09165	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GWK91_RS09175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWK91_RS09185	COG0166	Belongs to the GPI family
GWK91_RS09190	COG1979	alcohol dehydrogenase
GWK91_RS09195	COG1098	S1 RNA binding domain
GWK91_RS09200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWK91_RS09205	COG2032	superoxide dismutase activity
GWK91_RS09215	COG0813	purine-nucleoside phosphorylase activity
GWK91_RS09225	COG1268	BioY protein
GWK91_RS09230	COG3584	3D domain protein
GWK91_RS09240	COG1252	NADH dehydrogenase
GWK91_RS09255	COG0316	Belongs to the HesB IscA family
GWK91_RS09260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWK91_RS09265	COG4837	Protein of unknown function (DUF1462)
GWK91_RS09270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWK91_RS09280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWK91_RS09285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWK91_RS09290	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWK91_RS09295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWK91_RS09300	COG0647	UMP catabolic process
GWK91_RS09305	COG2445	Protein of unknown function DUF86
GWK91_RS09320	COG4470	Protein conserved in bacteria
GWK91_RS09330	COG0739	heme binding
GWK91_RS09340	COG0733	neurotransmitter:sodium symporter activity
GWK91_RS09345	COG1757	Na H antiporter
GWK91_RS09355	COG3377	Domain of unknown function (DUF1805)
GWK91_RS09360	COG0737	Belongs to the 5'-nucleotidase family
GWK91_RS09365	COG0730	response to heat
GWK91_RS09370	COG0719	Fe-S assembly protein
GWK91_RS09375	COG0822	iron-sulfur transferase activity
GWK91_RS09380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWK91_RS09385	COG0719	Fe-S assembly protein
GWK91_RS09390	COG0396	ATPase activity
GWK91_RS09395	COG1464	Belongs to the NlpA lipoprotein family
GWK91_RS09400	COG2011	ABC-type metal ion transport system permease component
GWK91_RS09405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWK91_RS09410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_RS09415	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GWK91_RS09420	COG0509	glycine decarboxylation via glycine cleavage system
GWK91_RS09425	COG1393	Belongs to the ArsC family
GWK91_RS09430	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS09435	COG0183	Belongs to the thiolase family
GWK91_RS09440	COG1024	Enoyl-CoA hydratase
GWK91_RS09440	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK91_RS09450	COG5577	PFAM Coat F domain
GWK91_RS09465	COG1121	(ABC) transporter
GWK91_RS09470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWK91_RS09475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWK91_RS09485	COG2508	Transcriptional regulator
GWK91_RS09495	COG1473	amidohydrolase
GWK91_RS09505	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS09510	COG0006	proline dipeptidase activity
GWK91_RS09545	COG1131	(ABC) transporter
GWK91_RS09555	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS09560	COG2133	pyrroloquinoline quinone binding
GWK91_RS09565	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS09570	COG3594	Acyltransferase
GWK91_RS09580	COG4607	ABC-type enterochelin transport system periplasmic component
GWK91_RS09585	COG4604	ABC transporter, ATP-binding protein
GWK91_RS09590	COG4605	iron ion homeostasis
GWK91_RS09595	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK91_RS09605	COG1413	lyase activity
GWK91_RS09610	COG2070	2-Nitropropane dioxygenase
GWK91_RS09625	COG2358	TRAP transporter, solute receptor (TAXI family
GWK91_RS09630	COG4565	transcriptional regulatory protein
GWK91_RS09635	COG3290	protein histidine kinase activity
GWK91_RS09640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWK91_RS09655	COG2112	serine threonine protein kinase
GWK91_RS09660	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS09695	COG2130	NADP-dependent
GWK91_RS09715	COG2217	Heavy metal translocating P-type atpase
GWK91_RS09720	COG1937	Protein conserved in bacteria
GWK91_RS09725	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS09735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK91_RS09745	COG0590	tRNA wobble adenosine to inosine editing
GWK91_RS09750	COG0656	L-ascorbic acid biosynthetic process
GWK91_RS09755	COG0493	'glutamate synthase
GWK91_RS09760	COG0069	glutamate synthase activity
GWK91_RS09760	COG0070	glutamate synthase
GWK91_RS09760	COG0067	glutamate synthase
GWK91_RS09765	COG0583	DNA-binding transcription factor activity
GWK91_RS09770	COG2368	4-hydroxyphenylacetate
GWK91_RS09780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWK91_RS09790	COG0557	exoribonuclease II activity
GWK91_RS09800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWK91_RS09805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK91_RS09825	COG0148	phosphopyruvate hydratase activity
GWK91_RS09830	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWK91_RS09835	COG0149	triose-phosphate isomerase activity
GWK91_RS09840	COG0126	phosphoglycerate kinase activity
GWK91_RS09845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWK91_RS09860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWK91_RS09865	COG2155	Conserved Protein
GWK91_RS09875	COG0740	serine-type endopeptidase activity
GWK91_RS09880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK91_RS09885	COG1481	regulation of sporulation
GWK91_RS09890	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GWK91_RS09895	COG1660	Displays ATPase and GTPase activities
GWK91_RS09900	COG1051	belongs to the nudix hydrolase family
GWK91_RS09905	COG0492	ferredoxin-NADP+ reductase activity
GWK91_RS09915	COG0768	penicillin binding
GWK91_RS09920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWK91_RS09925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWK91_RS09930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWK91_RS09935	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GWK91_RS09940	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GWK91_RS09945	COG1461	Dihydroxyacetone kinase
GWK91_RS09950	COG2376	Dihydroxyacetone kinase
GWK91_RS09955	COG2801	Transposase and inactivated derivatives
GWK91_RS09965	COG0110	maltose O-acetyltransferase activity
GWK91_RS09975	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GWK91_RS09980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWK91_RS09985	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GWK91_RS09990	COG1950	PFAM Membrane protein of
GWK91_RS09995	COG3595	metallopeptidase activity
GWK91_RS10000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GWK91_RS10005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GWK91_RS10010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWK91_RS10015	COG0556	nucleotide-excision repair
GWK91_RS10020	COG2197	response regulator
GWK91_RS10025	COG0366	Alpha amylase catalytic
GWK91_RS10030	COG2188	Transcriptional regulator
GWK91_RS10035	COG0366	Alpha amylase catalytic
GWK91_RS10040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK91_RS10040	COG1263	PTS System
GWK91_RS10050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK91_RS10055	COG0793	Belongs to the peptidase S41A family
GWK91_RS10055	COG3409	Peptidoglycan-binding domain 1 protein
GWK91_RS10060	COG0739	heme binding
GWK91_RS10065	COG2177	Part of the ABC transporter FtsEX involved in
GWK91_RS10070	COG2884	Cell division ATP-binding protein ftsE
GWK91_RS10080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK91_RS10090	COG0653	protein targeting
GWK91_RS10095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GWK91_RS10110	COG1516	flagellar protein fliS
GWK91_RS10115	COG1334	flagellar protein FlaG
GWK91_RS10120	COG0840	transmembrane signaling receptor activity
GWK91_RS10140	COG0840	transmembrane signaling receptor activity
GWK91_RS10145	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GWK91_RS10160	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GWK91_RS10165	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GWK91_RS10175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWK91_RS10180	COG1256	bacterial-type flagellum assembly
GWK91_RS10180	COG4786	Flagellar basal body rod
GWK91_RS10200	COG1040	competence protein
GWK91_RS10205	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GWK91_RS10210	COG1307	EDD domain protein, DegV family
GWK91_RS10225	COG2197	response regulator
GWK91_RS10230	COG4585	Histidine kinase
GWK91_RS10235	COG1739	Uncharacterized protein family UPF0029
GWK91_RS10250	COG1316	TRANSCRIPTIONal
GWK91_RS10255	COG1316	TRANSCRIPTIONal
GWK91_RS10260	COG1943	Transposase
GWK91_RS10265	COG1082	Xylose isomerase domain protein TIM barrel
GWK91_RS10270	COG1609	Transcriptional regulator
GWK91_RS10280	COG1129	ABC transporter
GWK91_RS10285	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWK91_RS10290	COG0673	inositol 2-dehydrogenase activity
GWK91_RS10295	COG0395	ABC-type sugar transport system, permease component
GWK91_RS10300	COG1175	transmembrane transport
GWK91_RS10310	COG2207	Transcriptional regulator
GWK91_RS10310	COG4753	response regulator
GWK91_RS10315	COG2972	Histidine kinase
GWK91_RS10325	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GWK91_RS10330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWK91_RS10335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWK91_RS10340	COG3842	ATPase activity
GWK91_RS10345	COG1472	Belongs to the glycosyl hydrolase 3 family
GWK91_RS10350	COG2508	Transcriptional regulator
GWK91_RS10355	COG0514	ATP-dependent DNA helicase (RecQ)
GWK91_RS10360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK91_RS10370	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS10375	COG0363	glucosamine-6-phosphate deaminase activity
GWK91_RS10380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWK91_RS10385	COG2188	Transcriptional regulator
GWK91_RS10400	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS10405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK91_RS10410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK91_RS10415	COG0579	oxidoreductase
GWK91_RS10420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWK91_RS10435	COG3409	Peptidoglycan-binding domain 1 protein
GWK91_RS10435	COG5632	N-Acetylmuramoyl-L-alanine amidase
GWK91_RS10435	COG1388	LysM domain
GWK91_RS10440	COG1254	Belongs to the acylphosphatase family
GWK91_RS10445	COG0247	lactate metabolic process
GWK91_RS10450	COG0277	FAD linked oxidase domain protein
GWK91_RS10455	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS10460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWK91_RS10465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GWK91_RS10470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWK91_RS10485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK91_RS10500	COG4106	trans-aconitate 2-methyltransferase activity
GWK91_RS10515	COG0328	RNA-DNA hybrid ribonuclease activity
GWK91_RS10525	COG1063	alcohol dehydrogenase
GWK91_RS10535	COG1414	Transcriptional regulator
GWK91_RS10545	COG0473	3-isopropylmalate dehydrogenase activity
GWK91_RS10550	COG0183	Belongs to the thiolase family
GWK91_RS10555	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS10560	COG1024	Enoyl-CoA hydratase
GWK91_RS10565	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK91_RS10580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK91_RS10585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK91_RS10595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWK91_RS10600	COG0210	DNA helicase
GWK91_RS10610	COG0861	Integral membrane protein TerC family
GWK91_RS10635	COG2706	6-phosphogluconolactonase activity
GWK91_RS10645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK91_RS10650	COG0840	transmembrane signaling receptor activity
GWK91_RS10655	COG1114	Component of the transport system for branched-chain amino acids
GWK91_RS10660	COG1802	Transcriptional regulator
GWK91_RS10665	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS10670	COG4145	pantothenate transmembrane transporter activity
GWK91_RS10680	COG1879	ABC-type sugar transport system periplasmic component
GWK91_RS10685	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWK91_RS10690	COG1129	ABC transporter
GWK91_RS10695	COG1869	D-ribose catabolic process
GWK91_RS10700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK91_RS10705	COG1609	Transcriptional regulator
GWK91_RS10710	COG2190	(PTS) system
GWK91_RS10710	COG1263	PTS System
GWK91_RS10710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK91_RS10715	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GWK91_RS10720	COG1737	Transcriptional regulator
GWK91_RS10725	COG1757	Na H antiporter
GWK91_RS10730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWK91_RS10735	COG3290	protein histidine kinase activity
GWK91_RS10735	COG3829	transcription factor binding
GWK91_RS10740	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GWK91_RS10745	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWK91_RS10750	COG2188	Transcriptional regulator
GWK91_RS10755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK91_RS10765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWK91_RS10770	COG1957	nucleoside hydrolase
GWK91_RS10780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK91_RS10785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWK91_RS10795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK91_RS10800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK91_RS10800	COG1522	sequence-specific DNA binding
GWK91_RS10815	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS10820	COG2358	TRAP transporter, solute receptor (TAXI family
GWK91_RS10830	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWK91_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS10860	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS10865	COG0318	PFAM AMP-dependent synthetase and ligase
GWK91_RS10870	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS10875	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS10895	COG2030	dehydratase
GWK91_RS10915	COG0693	protein deglycase activity
GWK91_RS10920	COG1830	Aldolase
GWK91_RS10925	COG1879	ABC-type sugar transport system periplasmic component
GWK91_RS10930	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWK91_RS10950	COG1070	Carbohydrate kinase
GWK91_RS10960	COG1979	alcohol dehydrogenase
GWK91_RS10970	COG0529	Catalyzes the synthesis of activated sulfate
GWK91_RS10975	COG0471	metal ion transport
GWK91_RS10975	COG3273	potassium ion transport
GWK91_RS10980	COG2046	Belongs to the sulfate adenylyltransferase family
GWK91_RS10985	COG2197	response regulator
GWK91_RS10990	COG0840	transmembrane signaling receptor activity
GWK91_RS11005	COG0154	amidase activity
GWK91_RS11110	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWK91_RS11140	COG0438	transferase activity, transferring glycosyl groups
GWK91_RS11145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GWK91_RS11155	COG1086	Polysaccharide biosynthesis protein
GWK91_RS11170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWK91_RS11175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWK91_RS11185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK91_RS11190	COG4464	protein tyrosine phosphatase activity
GWK91_RS11195	COG0489	protein tyrosine kinase activity
GWK91_RS11200	COG3944	biosynthesis protein
GWK91_RS11210	COG0110	maltose O-acetyltransferase activity
GWK91_RS11220	COG0438	transferase activity, transferring glycosyl groups
GWK91_RS11225	COG0662	Cupin 2, conserved barrel domain protein
GWK91_RS11225	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GWK91_RS11255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWK91_RS11260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GWK91_RS11265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK91_RS11285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWK91_RS11290	COG0463	Glycosyl transferase, family 2
GWK91_RS11320	COG0728	peptidoglycan biosynthetic process
GWK91_RS11335	COG0438	transferase activity, transferring glycosyl groups
GWK91_RS11370	COG1215	transferase activity, transferring glycosyl groups
GWK91_RS11370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK91_RS11375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK91_RS11380	COG4193	domain, Protein
GWK91_RS11390	COG1134	teichoic acid transport
GWK91_RS11395	COG1682	transport, permease protein
GWK91_RS11400	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK91_RS11405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWK91_RS11410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK91_RS11415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK91_RS11420	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GWK91_RS11425	COG3858	chitin binding
GWK91_RS11430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWK91_RS11455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWK91_RS11465	COG4786	Flagellar basal body rod
GWK91_RS11470	COG4786	Flagellar basal body rod
GWK91_RS11475	COG1077	Cell shape determining protein MreB Mrl
GWK91_RS11480	COG1609	Transcriptional regulator
GWK91_RS11485	COG0471	metal ion transport
GWK91_RS11505	COG2385	sporulation resulting in formation of a cellular spore
GWK91_RS11510	COG0142	geranyltranstransferase activity
GWK91_RS11515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWK91_RS11525	COG4836	Membrane
GWK91_RS11530	COG1007	ATP synthesis coupled electron transport
GWK91_RS11535	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK91_RS11540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK91_RS11545	COG0713	ATP synthesis coupled electron transport
GWK91_RS11550	COG0839	Belongs to the complex I subunit 6 family
GWK91_RS11555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK91_RS11560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWK91_RS11565	COG0649	NAD binding
GWK91_RS11570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK91_RS11575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK91_RS11580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK91_RS11585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GWK91_RS11590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GWK91_RS11600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWK91_RS11605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWK91_RS11615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWK91_RS11620	COG0356	it plays a direct role in the translocation of protons across the membrane
GWK91_RS11635	COG1404	Belongs to the peptidase S8 family
GWK91_RS11640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GWK91_RS11645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWK91_RS11650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWK91_RS11655	COG4475	Protein of unknown function (DUF436)
GWK91_RS11660	COG0698	ribose 5-phosphate isomerase
GWK91_RS11665	COG0840	transmembrane signaling receptor activity
GWK91_RS11670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWK91_RS11675	COG1971	Probably functions as a manganese efflux pump
GWK91_RS11680	COG0009	L-threonylcarbamoyladenylate synthase
GWK91_RS11700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWK91_RS11705	COG1435	thymidine kinase activity
GWK91_RS11710	COG0254	rRNA binding
GWK91_RS11715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWK91_RS11720	COG1494	fructose-1,6-bisphosphatase
GWK91_RS11730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWK91_RS11740	COG2204	response regulator
GWK91_RS11745	COG0504	CTP synthase activity
GWK91_RS11750	COG3343	RNA polymerase activity
GWK91_RS11755	COG2801	Transposase and inactivated derivatives
GWK91_RS11765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK91_RS11765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK91_RS11765	COG1703	isobutyryl-CoA mutase activity
GWK91_RS11775	COG1703	isobutyryl-CoA mutase activity
GWK91_RS11780	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS11785	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS11790	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK91_RS11795	COG0183	Belongs to the thiolase family
GWK91_RS11800	COG2181	nitrate reductase activity
GWK91_RS11800	COG0247	lactate metabolic process
GWK91_RS11805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK91_RS11820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK91_RS11835	COG3465	dGTPase activity
GWK91_RS11840	COG1078	dGTPase activity
GWK91_RS11845	COG0095	Lipoate-protein ligase
GWK91_RS11855	COG0280	phosphate acetyltransferase
GWK91_RS11865	COG3773	Cell wall hydrolase
GWK91_RS11880	COG2363	Small membrane protein
GWK91_RS11890	COG0765	amino acid transport
GWK91_RS11900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK91_RS11905	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS11910	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS11930	COG2801	Transposase and inactivated derivatives
GWK91_RS11940	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS11945	COG0028	Belongs to the TPP enzyme family
GWK91_RS11950	COG0436	Aminotransferase
GWK91_RS11955	COG1757	Na H antiporter
GWK91_RS11960	COG1757	Na H antiporter
GWK91_RS11990	COG1764	response to oxidative stress
GWK91_RS11995	COG3189	MarR family transcriptional regulator
GWK91_RS12005	COG0861	Integral membrane protein TerC family
GWK91_RS12010	COG1960	acyl-CoA dehydrogenase activity
GWK91_RS12015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK91_RS12020	COG0765	amino acid transport
GWK91_RS12025	COG0765	amino acid transport
GWK91_RS12030	COG1126	abc transporter atp-binding protein
GWK91_RS12055	COG4637	Psort location Cytoplasmic, score
GWK91_RS12060	COG1472	Belongs to the glycosyl hydrolase 3 family
GWK91_RS12065	COG1607	acyl-coa hydrolase
GWK91_RS12070	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK91_RS12075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK91_RS12080	COG0156	8-amino-7-oxononanoate synthase activity
GWK91_RS12095	COG0723	plastoquinol--plastocyanin reductase activity
GWK91_RS12095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK91_RS12100	COG2323	membrane
GWK91_RS12120	COG1278	Cold shock
GWK91_RS12130	COG1404	Belongs to the peptidase S8 family
GWK91_RS12135	COG2755	lipolytic protein G-D-S-L family
GWK91_RS12150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK91_RS12155	COG2814	Major facilitator Superfamily
GWK91_RS12160	COG0154	amidase activity
GWK91_RS12180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK91_RS12185	COG3973	AAA domain
GWK91_RS12195	COG4166	transmembrane transport
GWK91_RS12200	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWK91_RS12205	COG1329	Transcriptional regulator
GWK91_RS12210	COG0006	proline dipeptidase activity
GWK91_RS12215	COG2423	ornithine cyclodeaminase activity
GWK91_RS12220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK91_RS12225	COG0534	Mate efflux family protein
GWK91_RS12230	COG1575	Belongs to the MenA family. Type 1 subfamily
GWK91_RS12255	COG0788	formyltetrahydrofolate deformylase activity
GWK91_RS12260	COG0551	DNA topoisomerase type I activity
GWK91_RS12260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWK91_RS12265	COG2814	Major facilitator Superfamily
GWK91_RS12270	COG2204	response regulator
GWK91_RS12275	COG3852	Histidine kinase
GWK91_RS12300	COG0456	acetyltransferase
GWK91_RS12305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWK91_RS12310	COG1917	Cupin 2, conserved barrel domain protein
GWK91_RS12320	COG4213	ABC transporter substrate-binding protein
GWK91_RS12330	COG1131	(ABC) transporter
GWK91_RS12340	COG4152	abc transporter atp-binding protein
GWK91_RS12345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GWK91_RS12350	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GWK91_RS12365	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWK91_RS12370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWK91_RS12375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK91_RS12380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK91_RS12385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWK91_RS12390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK91_RS12395	COG3104	oligopeptide transport
GWK91_RS12415	COG2814	Major facilitator Superfamily
GWK91_RS12445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK91_RS12450	COG1266	CAAX protease self-immunity
GWK91_RS12460	COG1063	alcohol dehydrogenase
GWK91_RS12480	COG5002	protein histidine kinase activity
GWK91_RS12485	COG0745	RESPONSE REGULATOR receiver
GWK91_RS12490	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GWK91_RS12495	COG0460	homoserine dehydrogenase
GWK91_RS12510	COG1404	Belongs to the peptidase S8 family
GWK91_RS12515	COG1114	Component of the transport system for branched-chain amino acids
GWK91_RS12535	COG1802	Transcriptional regulator
GWK91_RS12545	COG2610	gluconate transmembrane transporter activity
GWK91_RS12580	COG4536	flavin adenine dinucleotide binding
GWK91_RS12590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK91_RS12595	COG0671	phosphoesterase, PA-phosphatase related
GWK91_RS12600	COG0579	oxidoreductase
GWK91_RS12605	COG0583	DNA-binding transcription factor activity
GWK91_RS12610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWK91_RS12615	COG0154	amidase activity
GWK91_RS12635	COG1126	abc transporter atp-binding protein
GWK91_RS12640	COG0765	amino acid transport
GWK91_RS12645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK91_RS12675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWK91_RS12680	COG1522	sequence-specific DNA binding
GWK91_RS12685	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS12750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWK91_RS12760	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWK91_RS12845	COG1368	sulfuric ester hydrolase activity
GWK91_RS12850	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS12870	COG1510	regulation of RNA biosynthetic process
GWK91_RS12875	COG3842	ATPase activity
GWK91_RS12890	COG0546	phosphoglycolate phosphatase activity
GWK91_RS12905	COG0783	Belongs to the Dps family
GWK91_RS12930	COG0673	inositol 2-dehydrogenase activity
GWK91_RS12935	COG3716	PTS system mannose fructose sorbose family IID component
GWK91_RS12940	COG3715	PTS system
GWK91_RS12960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWK91_RS12965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK91_RS12970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GWK91_RS12985	COG5002	protein histidine kinase activity
GWK91_RS12990	COG0745	RESPONSE REGULATOR receiver
GWK91_RS12995	COG0739	heme binding
GWK91_RS13015	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GWK91_RS13035	COG0305	Participates in initiation and elongation during chromosome replication
GWK91_RS13040	COG0359	binds to the 23S rRNA
GWK91_RS13045	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GWK91_RS13050	COG4241	membrane
GWK91_RS13055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWK91_RS13060	COG0629	single-stranded DNA binding
GWK91_RS13065	COG0360	Binds together with S18 to 16S ribosomal RNA
GWK91_RS13070	COG0012	GTP binding
GWK91_RS13075	COG4481	Protein conserved in bacteria
GWK91_RS13080	COG3949	Membrane
GWK91_RS13095	COG1475	DNA binding
GWK91_RS13100	COG1192	Involved in chromosome partitioning
GWK91_RS13105	COG1475	DNA binding
GWK91_RS13110	COG0357	Ribosomal RNA small subunit methyltransferase G
GWK91_RS13115	COG0445	tRNA wobble uridine modification
GWK91_RS13120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWK91_RS13125	COG1847	R3H domain protein
GWK91_RS13130	COG0706	membrane insertase activity
GWK91_RS13135	COG0594	ribonuclease P activity
GWK91_RS13140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GWK91_RS13145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWK91_RS13150	COG0592	DNA-directed DNA polymerase activity
GWK91_RS13155	COG2501	S4 domain
GWK91_RS13160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWK91_RS13170	COG0187	DNA topoisomerase II activity
GWK91_RS13175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWK91_RS13190	COG0516	GMP reductase activity
GWK91_RS13190	COG0517	IMP dehydrogenase activity
GWK91_RS13205	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GWK91_RS13210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWK91_RS13220	COG1428	Deoxynucleoside kinase
GWK91_RS13225	COG1428	Deoxynucleoside kinase
GWK91_RS13230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWK91_RS13240	COG0561	phosphatase activity
GWK91_RS13245	COG0697	spore germination
GWK91_RS13265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK91_RS13270	COG2233	PERMEase
GWK91_RS13280	COG3858	chitin binding
GWK91_RS13280	COG1388	LysM domain
GWK91_RS13295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GWK91_RS13300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GWK91_RS13305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWK91_RS13340	COG1982	Orn Lys Arg decarboxylase major
GWK91_RS13345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWK91_RS13350	COG3870	Protein conserved in bacteria
GWK91_RS13355	COG1728	Protein conserved in bacteria
GWK91_RS13360	COG0470	DNA polymerase III
GWK91_RS13365	COG1774	PSP1 C-terminal conserved region
GWK91_RS13370	COG4467	Involved in initiation control of chromosome replication
GWK91_RS13375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GWK91_RS13380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWK91_RS13385	COG2002	toxin-antitoxin pair type II binding
GWK91_RS13395	COG0084	hydrolase, TatD family'
GWK91_RS13400	COG3583	domain protein
GWK91_RS13400	COG3584	3D domain protein
GWK91_RS13410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWK91_RS13420	COG4466	Protein conserved in bacteria
GWK91_RS13430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWK91_RS13435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWK91_RS13440	COG2088	sporulation resulting in formation of a cellular spore
GWK91_RS13445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWK91_RS13450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWK91_RS13455	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWK91_RS13460	COG0193	aminoacyl-tRNA hydrolase activity
GWK91_RS13470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWK91_RS13475	COG2002	toxin-antitoxin pair type II binding
GWK91_RS13480	COG2244	polysaccharide biosynthetic process
GWK91_RS13485	COG3956	TIGRFAM MazG family protein
GWK91_RS13490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GWK91_RS13505	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWK91_RS13510	COG1098	S1 RNA binding domain
GWK91_RS13525	COG2208	phosphoserine phosphatase activity
GWK91_RS13530	COG2304	oxidoreductase activity
GWK91_RS13535	COG0515	serine threonine protein kinase
GWK91_RS13540	COG0037	tRNA processing
GWK91_RS13550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK91_RS13555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWK91_RS13560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWK91_RS13565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK91_RS13570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWK91_RS13575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GWK91_RS13580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWK91_RS13585	COG1396	sequence-specific DNA binding
GWK91_RS13590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWK91_RS13670	COG1285	pathogenesis
GWK91_RS13680	COG3880	PFAM UvrB UvrC protein
GWK91_RS13685	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GWK91_RS13690	COG0542	response to heat
GWK91_RS13695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWK91_RS13700	COG4956	integral membrane protein (PIN domain superfamily)
GWK91_RS13705	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWK91_RS13705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWK91_RS13710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWK91_RS13715	COG1045	serine acetyltransferase
GWK91_RS13720	COG0215	cysteine-tRNA ligase activity
GWK91_RS13730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWK91_RS13735	COG3688	RNA-binding protein containing a PIN domain
GWK91_RS13745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWK91_RS13750	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWK91_RS13755	COG0250	Participates in transcription elongation, termination and antitermination
GWK91_RS13765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWK91_RS13770	COG0081	regulation of translation
GWK91_RS13775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWK91_RS13780	COG0222	ribosome binding
GWK91_RS13785	COG2813	Specifically methylates the guanine in position
GWK91_RS13790	COG0085	RNA polymerase activity
GWK91_RS13795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWK91_RS13800	COG1358	cellular component organization or biogenesis
GWK91_RS13805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWK91_RS13810	COG0049	tRNA binding
GWK91_RS13815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWK91_RS13825	COG0051	transcription antitermination factor activity, RNA binding
GWK91_RS13830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWK91_RS13835	COG0088	Forms part of the polypeptide exit tunnel
GWK91_RS13840	COG0089	rRNA binding
GWK91_RS13845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWK91_RS13850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWK91_RS13855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWK91_RS13860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWK91_RS13865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWK91_RS13870	COG0255	Belongs to the universal ribosomal protein uL29 family
GWK91_RS13880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWK91_RS13890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWK91_RS13895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWK91_RS13900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWK91_RS13905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWK91_RS13910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWK91_RS13915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWK91_RS13920	COG1841	ribosomal large subunit assembly
GWK91_RS13925	COG0200	Binds to the 23S rRNA
GWK91_RS13930	COG0201	protein transport
GWK91_RS13935	COG0563	adenylate kinase activity
GWK91_RS13940	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GWK91_RS13945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWK91_RS13950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWK91_RS13955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWK91_RS13960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWK91_RS13965	COG0202	RNA polymerase activity
GWK91_RS13970	COG0203	ribosomal protein L17
GWK91_RS13975	COG1122	ATPase activity
GWK91_RS13980	COG1122	ATPase activity
GWK91_RS13990	COG0101	tRNA pseudouridine synthase activity
GWK91_RS14000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWK91_RS14005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWK91_RS14010	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK91_RS14015	COG0489	protein tyrosine kinase activity
GWK91_RS14025	COG2194	sulfuric ester hydrolase activity
GWK91_RS14030	COG0726	polysaccharide deacetylase
GWK91_RS14115	COG1595	DNA-templated transcription, initiation
GWK91_RS14120	COG5662	AntiSigma factor
GWK91_RS14125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GWK91_RS14130	COG4856	YbbR-like protein
GWK91_RS14135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK91_RS14140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWK91_RS14160	COG2113	Glycine betaine
GWK91_RS14165	COG1309	transcriptional regulator
GWK91_RS14175	COG2814	Major facilitator Superfamily
GWK91_RS14190	COG0431	NADPH-dependent FMN reductase
GWK91_RS14200	COG1733	regulation of RNA biosynthetic process
GWK91_RS14220	COG2217	Heavy metal translocating P-type atpase
GWK91_RS14240	COG0432	Pfam Uncharacterised protein family UPF0047
GWK91_RS14245	COG2814	Major facilitator Superfamily
GWK91_RS14250	COG0477	Major facilitator Superfamily
GWK91_RS14255	COG1846	Transcriptional regulator
GWK91_RS14265	COG2514	catechol 2,3-dioxygenase activity
GWK91_RS14270	COG1929	Belongs to the glycerate kinase type-1 family
GWK91_RS14275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWK91_RS14280	COG1252	NADH dehydrogenase
GWK91_RS14295	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWK91_RS14315	COG0488	(ABC) transporter
GWK91_RS14325	COG0697	spore germination
GWK91_RS14345	COG0789	Transcriptional regulator
GWK91_RS14355	COG0745	RESPONSE REGULATOR receiver
GWK91_RS14360	COG3850	Histidine kinase
GWK91_RS14360	COG5002	protein histidine kinase activity
GWK91_RS14380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK91_RS14385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK91_RS14405	COG1380	Effector of murein hydrolase LrgA
GWK91_RS14410	COG1346	cytolysis
GWK91_RS14415	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GWK91_RS14430	COG1227	inorganic diphosphatase activity
GWK91_RS14435	COG0561	phosphatase activity
GWK91_RS14445	COG5506	Protein of unknown function (DUF1694)
GWK91_RS14465	COG4585	Histidine kinase
GWK91_RS14470	COG2197	response regulator
GWK91_RS14485	COG0393	Putative heavy-metal-binding
GWK91_RS14490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK91_RS14490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK91_RS14495	COG0307	riboflavin synthase, alpha
GWK91_RS14500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWK91_RS14500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWK91_RS14505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWK91_RS14510	COG0454	-acetyltransferase
GWK91_RS14510	COG0456	acetyltransferase
GWK91_RS14515	COG5577	PFAM Coat F domain
GWK91_RS14530	COG1278	Cold shock
GWK91_RS14535	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GWK91_RS14540	COG2153	protein acetylation
GWK91_RS14545	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWK91_RS14560	COG3584	3D domain protein
GWK91_RS14560	COG1388	LysM domain
GWK91_RS14580	COG1024	Enoyl-CoA hydratase
GWK91_RS14590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWK91_RS14595	COG3859	Proton-coupled thiamine transporter YuaJ
GWK91_RS14605	COG0129	dihydroxy-acid dehydratase activity
GWK91_RS14610	COG0028	Belongs to the TPP enzyme family
GWK91_RS14615	COG0440	acetolactate synthase activity
GWK91_RS14620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWK91_RS14625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK91_RS14630	COG0473	3-isopropylmalate dehydrogenase activity
GWK91_RS14635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWK91_RS14640	COG0066	3-isopropylmalate dehydratase activity
GWK91_RS14645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK91_RS14650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GWK91_RS14655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK91_RS14660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK91_RS14665	COG1120	ATPase activity
GWK91_RS14675	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWK91_RS14680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWK91_RS14685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GWK91_RS14695	COG0131	Imidazoleglycerol-phosphate dehydratase
GWK91_RS14700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWK91_RS14705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWK91_RS14710	COG0107	imidazoleglycerol-phosphate synthase activity
GWK91_RS14715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWK91_RS14715	COG0140	phosphoribosyl-ATP diphosphatase activity
GWK91_RS14720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWK91_RS14750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK91_RS14760	COG2258	MOSC domain
GWK91_RS14765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK91_RS14780	COG1131	(ABC) transporter
GWK91_RS14820	COG0705	Rhomboid family
GWK91_RS14825	COG0736	holo-[acyl-carrier-protein] synthase activity
GWK91_RS14830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWK91_RS14840	COG0864	Transcriptional regulator
GWK91_RS14845	COG2337	Toxic component of a toxin-antitoxin (TA) module
GWK91_RS14850	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK91_RS14855	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK91_RS14860	COG2172	sigma factor antagonist activity
GWK91_RS14865	COG2208	phosphoserine phosphatase activity
GWK91_RS14875	COG2172	sigma factor antagonist activity
GWK91_RS14880	COG1191	sigma factor activity
GWK91_RS14885	COG2208	phosphoserine phosphatase activity
GWK91_RS14890	COG2183	response to ionizing radiation
GWK91_RS14900	COG3091	SprT-like family
GWK91_RS14995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWK91_RS15000	COG0802	atpase or kinase
GWK91_RS15005	COG1214	PFAM Peptidase M22, glycoprotease
GWK91_RS15010	COG0456	acetyltransferase
GWK91_RS15020	COG0488	(ABC) transporter
GWK91_RS15025	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GWK91_RS15035	COG1266	CAAX protease self-immunity
GWK91_RS15040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWK91_RS15045	COG0459	protein refolding
GWK91_RS15050	COG0582	viral genome integration into host DNA
GWK91_RS15070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWK91_RS15080	COG1309	transcriptional regulator
GWK91_RS15085	COG1393	Belongs to the ArsC family
GWK91_RS15090	COG1510	regulation of RNA biosynthetic process
GWK91_RS15105	COG2814	Major facilitator Superfamily
GWK91_RS15110	COG2801	Transposase and inactivated derivatives
GWK91_RS15120	COG1063	alcohol dehydrogenase
GWK91_RS15125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK91_RS15135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK91_RS15170	COG2304	oxidoreductase activity
GWK91_RS15225	COG4555	ABC transporter
GWK91_RS15255	COG0714	Associated with various cellular activities
GWK91_RS15260	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GWK91_RS15265	COG1305	Transglutaminase-like
GWK91_RS15270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK91_RS15270	COG0519	Catalyzes the synthesis of GMP from XMP
GWK91_RS15275	COG2252	PERMEase
GWK91_RS15290	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GWK91_RS15300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWK91_RS15310	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GWK91_RS15315	COG1470	cell adhesion involved in biofilm formation
GWK91_RS15320	COG4496	protein, YerC YecD
GWK91_RS15325	COG0423	glycine-tRNA ligase activity
GWK91_RS15330	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GWK91_RS15335	COG0210	DNA helicase
GWK91_RS15340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWK91_RS15345	COG4851	CamS sex pheromone cAM373 precursor
GWK91_RS15350	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS15355	COG1012	belongs to the aldehyde dehydrogenase family
GWK91_RS15360	COG0840	transmembrane signaling receptor activity
GWK91_RS15370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWK91_RS15375	COG2224	Isocitrate lyase
GWK91_RS15380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK91_RS15385	COG0154	amidase activity
GWK91_RS15390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK91_RS15395	COG1597	lipid kinase activity
GWK91_RS15400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWK91_RS15415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWK91_RS15425	COG0745	RESPONSE REGULATOR receiver
GWK91_RS15430	COG5002	protein histidine kinase activity
GWK91_RS15445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWK91_RS15465	COG1595	DNA-templated transcription, initiation
GWK91_RS15485	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS15490	COG2814	Major facilitator Superfamily
GWK91_RS15495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK91_RS15500	COG0010	Belongs to the arginase family
GWK91_RS15530	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWK91_RS15550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWK91_RS15555	COG0673	inositol 2-dehydrogenase activity
GWK91_RS15570	COG1077	Cell shape determining protein MreB Mrl
GWK91_RS15595	COG2135	peptidase activity
GWK91_RS15600	COG1595	DNA-templated transcription, initiation
GWK91_RS15620	COG1115	amino acid carrier protein
GWK91_RS15625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWK91_RS15635	COG1295	ribonuclease BN
GWK91_RS15640	COG2217	Heavy metal translocating P-type atpase
GWK91_RS15645	COG0477	Major facilitator Superfamily
GWK91_RS15655	COG0668	transmembrane transport
GWK91_RS15660	COG2056	Na+-H+ antiporter family
GWK91_RS15665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWK91_RS15675	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GWK91_RS15685	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GWK91_RS15690	COG0561	phosphatase activity
GWK91_RS15695	COG1028	Short-chain dehydrogenase reductase Sdr
GWK91_RS15700	COG0109	protoheme IX farnesyltransferase activity
GWK91_RS15715	COG2259	Doxx family
GWK91_RS15720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK91_RS15730	COG2409	Drug exporters of the RND superfamily
GWK91_RS15740	COG0785	Cytochrome C biogenesis protein
GWK91_RS15745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK91_RS15770	COG1063	alcohol dehydrogenase
GWK91_RS15805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWK91_RS15815	COG1459	type II secretion system
GWK91_RS15825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GWK91_RS15845	COG2832	Protein of unknown function (DUF454)
GWK91_RS15855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK91_RS15870	COG0667	Aldo Keto reductase
GWK91_RS15890	COG3764	Sortase (surface protein transpeptidase)
GWK91_RS15900	COG1131	(ABC) transporter
GWK91_RS15920	COG3942	CHAP domain
GWK91_RS15920	COG1388	LysM domain
GWK91_RS15935	COG2137	regulation of response to DNA damage stimulus
GWK91_RS15955	COG1988	membrane-bound metal-dependent
GWK91_RS15960	COG1194	a g-specific adenine glycosylase
GWK91_RS15970	COG3557	Belongs to the UPF0374 family
GWK91_RS15975	COG1132	(ABC) transporter
GWK91_RS15980	COG0737	Belongs to the 5'-nucleotidase family
GWK91_RS15980	COG1525	nuclease
GWK91_RS15980	COG4085	toxin activity
GWK91_RS15985	COG2353	YceI-like domain
GWK91_RS16005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWK91_RS16010	COG1595	DNA-templated transcription, initiation
GWK91_RS16020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWK91_RS16025	COG0512	Glutamine amidotransferase of anthranilate synthase
GWK91_RS16025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWK91_RS16030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWK91_RS16040	COG0135	phosphoribosylanthranilate isomerase activity
GWK91_RS16055	COG0569	domain protein
GWK91_RS16055	COG0475	glutathione-regulated potassium exporter activity
GWK91_RS16065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK91_RS16070	COG0679	Auxin Efflux Carrier
GWK91_RS16090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWK91_RS16095	COG2096	Adenosyltransferase
GWK91_RS16100	COG0735	belongs to the Fur family
GWK91_RS16200	COG4974	Belongs to the 'phage' integrase family
GWK91_RS16245	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWK91_RS16300	COG0517	IMP dehydrogenase activity
GWK91_RS16300	COG4175	Glycine betaine
GWK91_RS16305	COG4176	ABC-type proline glycine betaine transport system permease component
GWK91_RS16355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK91_RS16365	COG1785	Belongs to the alkaline phosphatase family
GWK91_RS16405	COG0681	Belongs to the peptidase S26 family
GWK91_RS16430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK91_RS16455	COG3588	fructose-bisphosphate aldolase
GWK91_RS16465	COG2304	oxidoreductase activity
GWK91_RS16480	COG1368	sulfuric ester hydrolase activity
GWK91_RS16490	COG1725	Transcriptional regulator
GWK91_RS16495	COG1131	(ABC) transporter
GWK91_RS16510	COG1595	DNA-templated transcription, initiation
GWK91_RS16515	COG2223	nitrite transmembrane transporter activity