locus-tag	class	description
X953_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
X953_RS00010	COG0592	DNA-directed DNA polymerase activity
X953_RS00015	COG2501	S4 domain
X953_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
X953_RS00030	COG0187	DNA topoisomerase II activity
X953_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
X953_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
X953_RS00050	COG0517	IMP dehydrogenase activity
X953_RS00050	COG0516	GMP reductase activity
X953_RS00060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
X953_RS00065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
X953_RS00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
X953_RS00075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
X953_RS00080	COG2011	ABC-type metal ion transport system permease component
X953_RS00085	COG1464	Belongs to the NlpA lipoprotein family
X953_RS00100	COG2357	RelA SpoT domain protein
X953_RS00105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
X953_RS00110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X953_RS00115	COG1428	Deoxynucleoside kinase
X953_RS00120	COG1428	Deoxynucleoside kinase
X953_RS00130	COG1301	dicarboxylic acid transport
X953_RS00140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X953_RS00145	COG3425	synthase
X953_RS00150	COG1017	nitric oxide dioxygenase activity
X953_RS00150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X953_RS00155	COG1959	2 iron, 2 sulfur cluster binding
X953_RS00160	COG0693	protein deglycase activity
X953_RS00165	COG1388	LysM domain
X953_RS00165	COG3858	chitin binding
X953_RS00170	COG1335	isochorismatase
X953_RS00175	COG0590	tRNA wobble adenosine to inosine editing
X953_RS00185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
X953_RS00190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
X953_RS00195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
X953_RS00215	COG1982	Orn Lys Arg decarboxylase major
X953_RS00220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
X953_RS00225	COG3870	Protein conserved in bacteria
X953_RS00230	COG1728	Protein conserved in bacteria
X953_RS00235	COG0470	DNA polymerase III
X953_RS00240	COG1774	PSP1 C-terminal conserved region
X953_RS00245	COG4467	Involved in initiation control of chromosome replication
X953_RS00250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
X953_RS00255	COG2827	Endonuclease containing a URI domain
X953_RS00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
X953_RS00270	COG2002	toxin-antitoxin pair type II binding
X953_RS00280	COG0084	hydrolase, TatD family'
X953_RS00285	COG3583	domain protein
X953_RS00285	COG3584	3D domain protein
X953_RS00295	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
X953_RS00300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
X953_RS00310	COG4466	Protein conserved in bacteria
X953_RS00320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
X953_RS00325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
X953_RS00330	COG2088	sporulation resulting in formation of a cellular spore
X953_RS00335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
X953_RS00340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
X953_RS00345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
X953_RS00350	COG0193	aminoacyl-tRNA hydrolase activity
X953_RS00360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
X953_RS00365	COG2002	toxin-antitoxin pair type II binding
X953_RS00370	COG2244	polysaccharide biosynthetic process
X953_RS00375	COG3956	TIGRFAM MazG family protein
X953_RS00380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
X953_RS00405	COG1098	S1 RNA binding domain
X953_RS00415	COG2208	phosphoserine phosphatase activity
X953_RS00420	COG2304	oxidoreductase activity
X953_RS00425	COG0515	serine threonine protein kinase
X953_RS00430	COG0037	tRNA processing
X953_RS00435	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
X953_RS00440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
X953_RS00450	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
X953_RS00455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
X953_RS00460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X953_RS00465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X953_RS00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
X953_RS00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
X953_RS00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
X953_RS00490	COG1396	sequence-specific DNA binding
X953_RS00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
X953_RS00515	COG1285	pathogenesis
X953_RS00525	COG3880	PFAM UvrB UvrC protein
X953_RS00530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
X953_RS00535	COG0542	response to heat
X953_RS00545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
X953_RS00550	COG4956	integral membrane protein (PIN domain superfamily)
X953_RS00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X953_RS00560	COG1045	serine acetyltransferase
X953_RS00565	COG0215	cysteine-tRNA ligase activity
X953_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X953_RS00580	COG3688	RNA-binding protein containing a PIN domain
X953_RS00590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
X953_RS00595	COG0250	Participates in transcription elongation, termination and antitermination
X953_RS00600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
X953_RS00605	COG0081	regulation of translation
X953_RS00610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
X953_RS00615	COG0222	ribosome binding
X953_RS00620	COG2813	Specifically methylates the guanine in position
X953_RS00625	COG0085	RNA polymerase activity
X953_RS00630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
X953_RS00635	COG1358	cellular component organization or biogenesis
X953_RS00640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
X953_RS00645	COG0049	tRNA binding
X953_RS00650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
X953_RS00655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
X953_RS00660	COG0051	transcription antitermination factor activity, RNA binding
X953_RS00665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
X953_RS00670	COG0088	Forms part of the polypeptide exit tunnel
X953_RS00675	COG0089	rRNA binding
X953_RS00680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
X953_RS00685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
X953_RS00690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
X953_RS00695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
X953_RS00700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
X953_RS00705	COG0255	Belongs to the universal ribosomal protein uL29 family
X953_RS00710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
X953_RS00715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
X953_RS00720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
X953_RS00725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
X953_RS00730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
X953_RS00735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
X953_RS00740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
X953_RS00745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
X953_RS00750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
X953_RS00755	COG1841	ribosomal large subunit assembly
X953_RS00760	COG0200	Binds to the 23S rRNA
X953_RS00765	COG0201	protein transport
X953_RS00770	COG0563	adenylate kinase activity
X953_RS00775	COG2163	COG2163 Ribosomal protein L14E L6E L27E
X953_RS00780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
X953_RS00785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
X953_RS00790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
X953_RS00795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
X953_RS00800	COG0202	RNA polymerase activity
X953_RS00805	COG0203	ribosomal protein L17
X953_RS00815	COG1122	ATPase activity
X953_RS00820	COG1122	ATPase activity
X953_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
X953_RS00830	COG0101	tRNA pseudouridine synthase activity
X953_RS00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
X953_RS00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
X953_RS00940	COG1346	cytolysis
X953_RS00950	COG0583	DNA-binding transcription factor activity
X953_RS00955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
X953_RS00995	COG0714	Associated with various cellular activities
X953_RS01000	COG4548	von Willebrand factor, type A
X953_RS01020	COG1295	ribonuclease BN
X953_RS01045	COG0860	N-Acetylmuramoyl-L-alanine amidase
X953_RS01050	COG0489	protein tyrosine kinase activity
X953_RS01060	COG2194	sulfuric ester hydrolase activity
X953_RS01065	COG0726	polysaccharide deacetylase
X953_RS01120	COG0494	nUDIX hydrolase
X953_RS01125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
X953_RS01130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
X953_RS01195	COG1595	DNA-templated transcription, initiation
X953_RS01200	COG5662	AntiSigma factor
X953_RS01205	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
X953_RS01210	COG4856	YbbR-like protein
X953_RS01215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
X953_RS01220	COG0745	RESPONSE REGULATOR receiver
X953_RS01225	COG3850	Histidine kinase
X953_RS01225	COG5002	protein histidine kinase activity
X953_RS01230	COG0577	efflux transmembrane transporter activity
X953_RS01260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
X953_RS01295	COG0840	transmembrane signaling receptor activity
X953_RS01310	COG3706	GGDEF domain
X953_RS01385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
X953_RS01470	COG0084	hydrolase, TatD family'
X953_RS01550	COG3706	GGDEF domain
X953_RS01625	COG4974	Belongs to the 'phage' integrase family
X953_RS01650	COG2072	flavoprotein involved in K transport
X953_RS01690	COG0732	type I restriction modification DNA specificity domain
X953_RS01735	COG1484	DNA-dependent DNA replication
X953_RS01790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
X953_RS01795	COG1801	Protein of unknown function DUF72
X953_RS01800	COG0488	(ABC) transporter
X953_RS01805	COG3011	Protein conserved in bacteria
X953_RS01830	COG1271	oxidase subunit
X953_RS01835	COG1294	oxidase, subunit
X953_RS01840	COG4988	ABC transporter
X953_RS01845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
X953_RS01855	COG1309	transcriptional regulator
X953_RS01860	COG1131	(ABC) transporter
X953_RS01880	COG0243	molybdopterin cofactor binding
X953_RS01910	COG2223	nitrite transmembrane transporter activity
X953_RS01920	COG2197	response regulator
X953_RS01930	COG4585	Histidine kinase
X953_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS01945	COG1114	Component of the transport system for branched-chain amino acids
X953_RS01950	COG1802	Transcriptional regulator
X953_RS01955	COG0753	catalase activity
X953_RS01960	COG0668	transmembrane transport
X953_RS01975	COG1413	lyase activity
X953_RS01980	COG1607	acyl-coa hydrolase
X953_RS01990	COG2124	cytochrome p450
X953_RS01995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
X953_RS02000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
X953_RS02005	COG0083	homoserine kinase activity
X953_RS02010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
X953_RS02015	COG0460	homoserine dehydrogenase
X953_RS02025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X953_RS02030	COG2814	Major facilitator Superfamily
X953_RS02045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X953_RS02070	COG0589	response to stress
X953_RS02075	COG2855	membrane
X953_RS02085	COG0789	Transcriptional regulator
X953_RS02090	COG0352	thiamine-phosphate diphosphorylase activity
X953_RS02095	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
X953_RS02110	COG1063	alcohol dehydrogenase
X953_RS02130	COG4145	pantothenate transmembrane transporter activity
X953_RS02140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X953_RS02150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X953_RS02155	COG5506	Protein of unknown function (DUF1694)
X953_RS02165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
X953_RS02170	COG5577	PFAM Coat F domain
X953_RS02185	COG0708	Exodeoxyribonuclease III
X953_RS02190	COG1725	Transcriptional regulator
X953_RS02195	COG1131	(ABC) transporter
X953_RS02210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_RS02230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
X953_RS02235	COG0095	Lipoate-protein ligase
X953_RS02245	COG0159	tryptophan synthase activity
X953_RS02250	COG0133	tryptophan synthase activity
X953_RS02255	COG0135	phosphoribosylanthranilate isomerase activity
X953_RS02260	COG0134	indole-3-glycerol-phosphate synthase activity
X953_RS02265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
X953_RS02270	COG0512	Glutamine amidotransferase of anthranilate synthase
X953_RS02275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
X953_RS02280	COG1181	Belongs to the D-alanine--D-alanine ligase family
X953_RS02285	COG1115	amino acid carrier protein
X953_RS02290	COG0778	Nitroreductase
X953_RS02310	COG1418	mRNA catabolic process
X953_RS02315	COG1876	peptidase activity
X953_RS02320	COG2814	Major facilitator Superfamily
X953_RS02325	COG4166	transmembrane transport
X953_RS02330	COG1970	mechanosensitive ion channel activity
X953_RS02350	COG0519	Catalyzes the synthesis of GMP from XMP
X953_RS02355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
X953_RS02360	COG1268	BioY protein
X953_RS02365	COG0840	transmembrane signaling receptor activity
X953_RS02375	COG0154	amidase activity
X953_RS02380	COG0656	L-ascorbic acid biosynthetic process
X953_RS02395	COG1304	FMN binding
X953_RS02400	COG4876	unkown
X953_RS02405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_RS02410	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
X953_RS02415	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X953_RS02420	COG4605	iron ion homeostasis
X953_RS02425	COG4604	ABC transporter, ATP-binding protein
X953_RS02430	COG4607	ABC-type enterochelin transport system periplasmic component
X953_RS02435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X953_RS02440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X953_RS02445	COG0140	phosphoribosyl-ATP diphosphatase activity
X953_RS02445	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
X953_RS02450	COG0107	imidazoleglycerol-phosphate synthase activity
X953_RS02455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
X953_RS02460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
X953_RS02465	COG0131	Imidazoleglycerol-phosphate dehydratase
X953_RS02470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
X953_RS02475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
X953_RS02480	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
X953_RS02485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
X953_RS02490	COG2832	Protein of unknown function (DUF454)
X953_RS02500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
X953_RS02505	COG1126	abc transporter atp-binding protein
X953_RS02510	COG0765	amino acid transport
X953_RS02515	COG0765	amino acid transport
X953_RS02525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X953_RS02530	COG0673	inositol 2-dehydrogenase activity
X953_RS02535	COG1876	peptidase activity
X953_RS02540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
X953_RS02545	COG2839	Protein conserved in bacteria
X953_RS02550	COG0351	phosphomethylpyrimidine kinase
X953_RS02555	COG1335	isochorismatase
X953_RS02565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
X953_RS02575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X953_RS02580	COG0765	amino acid transport
X953_RS02585	COG1126	abc transporter atp-binding protein
X953_RS02590	COG0714	Associated with various cellular activities
X953_RS02595	COG0386	Belongs to the glutathione peroxidase family
X953_RS02600	COG3949	Membrane
X953_RS02605	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
X953_RS02605	COG2508	Transcriptional regulator
X953_RS02610	COG0686	Belongs to the AlaDH PNT family
X953_RS02615	COG1054	Belongs to the UPF0176 family
X953_RS02630	COG1278	Cold shock
X953_RS02640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
X953_RS02650	COG2084	Dehydrogenase
X953_RS02660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
X953_RS02665	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
X953_RS02670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X953_RS02675	COG0745	RESPONSE REGULATOR receiver
X953_RS02680	COG3850	Histidine kinase
X953_RS02680	COG5002	protein histidine kinase activity
X953_RS02685	COG1217	gtp-binding protein TYPA
X953_RS02690	COG1834	amidinotransferase
X953_RS02695	COG3403	YqcI/YcgG family
X953_RS02700	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
X953_RS02705	COG1131	(ABC) transporter
X953_RS02710	COG0183	Belongs to the thiolase family
X953_RS02730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_RS02740	COG0745	RESPONSE REGULATOR receiver
X953_RS02745	COG5002	protein histidine kinase activity
X953_RS02745	COG3850	Histidine kinase
X953_RS02760	COG1597	lipid kinase activity
X953_RS02765	COG1846	Transcriptional regulator
X953_RS02800	COG0513	Belongs to the DEAD box helicase family
X953_RS02805	COG0705	Rhomboid family
X953_RS02810	COG0736	holo-[acyl-carrier-protein] synthase activity
X953_RS02815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
X953_RS02815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
X953_RS02820	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
X953_RS02825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
X953_RS02835	COG2337	Toxic component of a toxin-antitoxin (TA) module
X953_RS02845	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_RS02850	COG2172	sigma factor antagonist activity
X953_RS02855	COG2208	phosphoserine phosphatase activity
X953_RS02860	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_RS02865	COG2172	sigma factor antagonist activity
X953_RS02870	COG1191	sigma factor activity
X953_RS02875	COG2208	phosphoserine phosphatase activity
X953_RS02880	COG2183	response to ionizing radiation
X953_RS02885	COG0753	catalase activity
X953_RS02890	COG3091	SprT-like family
X953_RS02980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
X953_RS02985	COG0802	atpase or kinase
X953_RS02990	COG1214	PFAM Peptidase M22, glycoprotease
X953_RS02995	COG0456	acetyltransferase
X953_RS03000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
X953_RS03005	COG0772	Belongs to the SEDS family
X953_RS03010	COG0488	(ABC) transporter
X953_RS03020	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
X953_RS03030	COG1266	CAAX protease self-immunity
X953_RS03035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
X953_RS03040	COG0459	protein refolding
X953_RS03045	COG0582	viral genome integration into host DNA
X953_RS03090	COG4372	Transposase
X953_RS03100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
X953_RS03120	COG4873	Protein conserved in bacteria
X953_RS03135	COG0789	Transcriptional regulator
X953_RS03135	COG4978	Transcriptional regulator
X953_RS03140	COG0456	acetyltransferase
X953_RS03145	COG1309	transcriptional regulator
X953_RS03150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X953_RS03155	COG0390	transport system, permease component
X953_RS03160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
X953_RS03165	COG0745	RESPONSE REGULATOR receiver
X953_RS03170	COG2205	protein histidine kinase activity
X953_RS03175	COG1136	(ABC) transporter
X953_RS03180	COG0577	efflux transmembrane transporter activity
X953_RS03185	COG0668	transmembrane transport
X953_RS03190	COG0697	spore germination
X953_RS03210	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
X953_RS03230	COG0714	Associated with various cellular activities
X953_RS03235	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
X953_RS03240	COG1305	Transglutaminase-like
X953_RS03245	COG0519	Catalyzes the synthesis of GMP from XMP
X953_RS03245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
X953_RS03250	COG2252	PERMEase
X953_RS03260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X953_RS03265	COG2258	MOSC domain
X953_RS03275	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
X953_RS03280	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS03285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
X953_RS03290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
X953_RS03295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
X953_RS03300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
X953_RS03305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X953_RS03310	COG0047	phosphoribosylformylglycinamidine synthase activity
X953_RS03315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X953_RS03320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
X953_RS03325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
X953_RS03330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
X953_RS03335	COG0138	bifunctional purine biosynthesis protein purh
X953_RS03340	COG0151	Belongs to the GarS family
X953_RS03345	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
X953_RS03350	COG1470	cell adhesion involved in biofilm formation
X953_RS03355	COG4496	protein, YerC YecD
X953_RS03360	COG0084	hydrolase, TatD family'
X953_RS03365	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
X953_RS03370	COG0210	DNA helicase
X953_RS03375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
X953_RS03380	COG4851	CamS sex pheromone cAM373 precursor
X953_RS03385	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS03395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X953_RS03400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
X953_RS03405	COG0154	amidase activity
X953_RS03410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
X953_RS03415	COG1597	lipid kinase activity
X953_RS03420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
X953_RS03435	COG0109	protoheme IX farnesyltransferase activity
X953_RS03450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
X953_RS03460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X953_RS03470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X953_RS03470	COG4499	WXG100 protein secretion system (Wss), protein YukC
X953_RS03480	COG3328	transposase activity
X953_RS03485	COG0109	protoheme IX farnesyltransferase activity
X953_RS03495	COG0166	Belongs to the GPI family
X953_RS03510	COG0778	Nitroreductase
X953_RS03515	COG0564	pseudouridine synthase activity
X953_RS03525	COG1785	Belongs to the alkaline phosphatase family
X953_RS03530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_RS03535	COG0488	(ABC) transporter
X953_RS03560	COG0446	pyridine nucleotide-disulphide oxidoreductase
X953_RS03565	COG0733	neurotransmitter:sodium symporter activity
X953_RS03570	COG1757	Na H antiporter
X953_RS03575	COG0436	Aminotransferase
X953_RS03580	COG0028	Belongs to the TPP enzyme family
X953_RS03585	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS03595	COG1414	Transcriptional regulator
X953_RS03605	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS03615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X953_RS03620	COG1077	Cell shape determining protein MreB Mrl
X953_RS03625	COG2340	Cysteine-rich secretory protein family
X953_RS03630	COG2066	Belongs to the glutaminase family
X953_RS03635	COG2135	peptidase activity
X953_RS03640	COG1115	amino acid carrier protein
X953_RS03650	COG1295	ribonuclease BN
X953_RS03655	COG2217	Heavy metal translocating P-type atpase
X953_RS03660	COG0477	Major facilitator Superfamily
X953_RS03680	COG2056	Na+-H+ antiporter family
X953_RS03690	COG5001	Diguanylate cyclase
X953_RS03690	COG3447	MASE1 domain protein
X953_RS03690	COG5002	protein histidine kinase activity
X953_RS03700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X953_RS03705	COG0542	response to heat
X953_RS03710	COG2333	competence protein COMEC
X953_RS03710	COG0658	competence protein
X953_RS03720	COG1131	(ABC) transporter
X953_RS03730	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
X953_RS03735	COG1131	(ABC) transporter
X953_RS03750	COG2188	Transcriptional regulator
X953_RS03770	COG1090	epimerase
X953_RS03775	COG2137	regulation of response to DNA damage stimulus
X953_RS03790	COG1988	membrane-bound metal-dependent
X953_RS03805	COG3557	Belongs to the UPF0374 family
X953_RS03810	COG1132	(ABC) transporter
X953_RS03815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
X953_RS03825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
X953_RS03830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
X953_RS03835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X953_RS03840	COG0735	belongs to the Fur family
X953_RS03850	COG0512	Glutamine amidotransferase of anthranilate synthase
X953_RS03965	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
X953_RS03985	COG0424	maF-like protein
X953_RS03995	COG1733	regulation of RNA biosynthetic process
X953_RS04005	COG0431	NADPH-dependent FMN reductase
X953_RS04010	COG2364	Membrane
X953_RS04020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_RS04030	COG1227	inorganic diphosphatase activity
X953_RS04050	COG4474	Belongs to the UPF0398 family
X953_RS04080	COG0456	acetyltransferase
X953_RS04085	COG1794	racemase activity, acting on amino acids and derivatives
X953_RS04105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
X953_RS04115	COG0519	Catalyzes the synthesis of GMP from XMP
X953_RS04140	COG4842	Belongs to the WXG100 family
X953_RS04145	COG5417	Belongs to the EsaB family
X953_RS04150	COG4499	WXG100 protein secretion system (Wss), protein YukC
X953_RS04155	COG1674	ftsk spoiiie
X953_RS04155	COG0433	COG0433 Predicted ATPase
X953_RS04160	COG1511	domain protein
X953_RS04180	COG5444	nuclease activity
X953_RS04225	COG5444	nuclease activity
X953_RS04300	COG2814	Major facilitator Superfamily
X953_RS04305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
X953_RS04310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
X953_RS04315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X953_RS04330	COG4166	transmembrane transport
X953_RS04335	COG0277	FAD linked oxidase domain protein
X953_RS04345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
X953_RS04350	COG1011	Hydrolase
X953_RS04355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X953_RS04375	COG1714	RDD family
X953_RS04380	COG2176	DNA-directed DNA polymerase activity
X953_RS04385	COG0616	signal peptide processing
X953_RS04390	COG1714	RDD family
X953_RS04395	COG0318	PFAM AMP-dependent synthetase and ligase
X953_RS04420	COG2233	PERMEase
X953_RS04425	COG2814	Major facilitator Superfamily
X953_RS04440	COG0604	alcohol dehydrogenase
X953_RS04450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
X953_RS04450	COG3320	Male sterility
X953_RS04475	COG2318	DinB family
X953_RS04485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
X953_RS04490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
X953_RS04495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
X953_RS04500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
X953_RS04505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
X953_RS04510	COG4946	Tricorn protease homolog
X953_RS04510	COG0823	Involved in the tonB-independent uptake of proteins
X953_RS04510	COG1506	peptidase
X953_RS04525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X953_RS04545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
X953_RS04555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
X953_RS04565	COG0508	dehydrogenase complex catalyzes the overall conversion of
X953_RS04570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
X953_RS04575	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS04580	COG0534	Mate efflux family protein
X953_RS04585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
X953_RS04605	COG0288	reversible hydration of carbon dioxide
X953_RS04615	COG1132	(ABC) transporter
X953_RS04620	COG1132	(ABC) transporter
X953_RS04625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X953_RS04635	COG1191	sigma factor activity
X953_RS04655	COG2226	methyltransferase
X953_RS04660	COG1854	S-ribosylhomocysteine lyase activity
X953_RS04665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X953_RS04670	COG0626	cystathionine gamma-synthase activity
X953_RS04675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X953_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS04690	COG1131	(ABC) transporter
X953_RS04695	COG0024	Methionine aminopeptidase
X953_RS04705	COG1757	Na H antiporter
X953_RS04710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
X953_RS04720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
X953_RS04730	COG2270	Major facilitator Superfamily
X953_RS04740	COG0114	fumarate hydratase activity
X953_RS04750	COG3842	ATPase activity
X953_RS04755	COG2508	Transcriptional regulator
X953_RS04760	COG3679	Belongs to the UPF0342 family
X953_RS04765	COG1024	Enoyl-CoA hydratase
X953_RS04775	COG4152	abc transporter atp-binding protein
X953_RS04780	COG1668	transmembrane transport
X953_RS04790	COG0420	3'-5' exonuclease activity
X953_RS04795	COG4717	serine-type aminopeptidase activity
X953_RS04800	COG1510	regulation of RNA biosynthetic process
X953_RS04805	COG3481	metal-dependent phosphohydrolase, HD sub domain
X953_RS04815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X953_RS04835	COG1510	regulation of RNA biosynthetic process
X953_RS04840	COG0517	IMP dehydrogenase activity
X953_RS04840	COG4175	Glycine betaine
X953_RS04860	COG4980	gas vesicle protein
X953_RS04870	COG0537	adenosine 5'-monophosphoramidase activity
X953_RS04875	COG1131	(ABC) transporter
X953_RS04880	COG4473	ABC transporter
X953_RS04885	COG1473	amidohydrolase
X953_RS04890	COG2193	ferroxidase activity
X953_RS04900	COG2814	Major facilitator Superfamily
X953_RS04910	COG4585	Histidine kinase
X953_RS04915	COG2197	response regulator
X953_RS04920	COG2329	Antibiotic biosynthesis monooxygenase
X953_RS04925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X953_RS04930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
X953_RS04935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
X953_RS04940	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
X953_RS04945	COG1164	Oligoendopeptidase f
X953_RS04950	COG1234	tRNA 3'-trailer cleavage
X953_RS04955	COG0095	Lipoate-protein ligase
X953_RS04960	COG0318	PFAM AMP-dependent synthetase and ligase
X953_RS04970	COG0398	Pfam SNARE associated Golgi protein
X953_RS04980	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
X953_RS04985	COG1074	ATP-dependent DNA helicase activity
X953_RS04990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
X953_RS04995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X953_RS05040	COG2311	Membrane
X953_RS05045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
X953_RS05065	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS05075	COG1307	EDD domain protein, DegV family
X953_RS05080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_RS05100	COG0561	phosphatase activity
X953_RS05105	COG1073	alpha beta
X953_RS05110	COG2151	metal-sulfur cluster biosynthetic enzyme
X953_RS05120	COG0314	molybdopterin synthase activity
X953_RS05130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X953_RS05140	COG0535	radical SAM domain protein
X953_RS05145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X953_RS05170	COG1744	ABC transporter substrate-binding protein PnrA-like
X953_RS05175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
X953_RS05180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
X953_RS05195	COG0180	Tryptophanyl-tRNA synthetase
X953_RS05205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
X953_RS05210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X953_RS05215	COG1116	anion transmembrane transporter activity
X953_RS05220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X953_RS05225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X953_RS05230	COG1388	LysM domain
X953_RS05240	COG0456	acetyltransferase
X953_RS05245	COG1393	Belongs to the ArsC family
X953_RS05250	COG4862	establishment of competence for transformation
X953_RS05260	COG1164	Oligoendopeptidase f
X953_RS05265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
X953_RS05270	COG2346	COG2346, Truncated hemoglobins
X953_RS05275	COG4116	CYTH
X953_RS05280	COG2357	RelA SpoT domain protein
X953_RS05285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
X953_RS05290	COG0564	pseudouridine synthase activity
X953_RS05295	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
X953_RS05300	COG2239	Acts as a magnesium transporter
X953_RS05330	COG2323	membrane
X953_RS05335	COG2153	protein acetylation
X953_RS05340	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
X953_RS05345	COG2382	esterase
X953_RS05350	COG1132	(ABC) transporter
X953_RS05355	COG1132	(ABC) transporter
X953_RS05365	COG0753	catalase activity
X953_RS05370	COG3443	Belongs to the bacterial solute-binding protein 9 family
X953_RS05370	COG0803	Belongs to the bacterial solute-binding protein 9 family
X953_RS05405	COG0436	Aminotransferase
X953_RS05425	COG0584	glycerophosphoryl diester phosphodiesterase
X953_RS05480	COG3729	General stress protein
X953_RS05485	COG0488	(ABC) transporter
X953_RS05500	COG3328	transposase activity
X953_RS05505	COG2130	NADP-dependent
X953_RS05520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X953_RS05530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X953_RS05545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
X953_RS05550	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
X953_RS05555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
X953_RS05560	COG0297	glycogen (starch) synthase activity
X953_RS05565	COG0697	spore germination
X953_RS05610	COG0579	oxidoreductase
X953_RS05670	COG2309	aminopeptidase activity
X953_RS05675	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_RS05710	COG0586	Pfam SNARE associated Golgi protein
X953_RS05720	COG1714	RDD family
X953_RS05740	COG1051	belongs to the nudix hydrolase family
X953_RS05775	COG0662	Cupin 2, conserved barrel domain protein
X953_RS05785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
X953_RS05785	COG0456	acetyltransferase
X953_RS05825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X953_RS05830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X953_RS05835	COG1120	ATPase activity
X953_RS05840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
X953_RS05845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X953_RS05855	COG1492	cobalamin metabolic process
X953_RS05860	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
X953_RS05865	COG0588	phosphoglycerate mutase activity
X953_RS05875	COG2096	Adenosyltransferase
X953_RS05900	COG1473	amidohydrolase
X953_RS05925	COG0653	protein targeting
X953_RS05935	COG0477	Major facilitator Superfamily
X953_RS06000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
X953_RS06055	COG0596	Alpha beta hydrolase
X953_RS06115	COG1247	-acetyltransferase
X953_RS06190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
X953_RS06190	COG0456	acetyltransferase
X953_RS06200	COG1063	alcohol dehydrogenase
X953_RS06220	COG3961	Belongs to the TPP enzyme family
X953_RS06225	COG1846	Transcriptional regulator
X953_RS06240	COG0346	lactoylglutathione lyase activity
X953_RS06245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
X953_RS06285	COG1266	CAAX protease self-immunity
X953_RS06300	COG2226	methyltransferase
X953_RS06345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
X953_RS06350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
X953_RS06355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
X953_RS06360	COG1268	BioY protein
X953_RS06390	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS06470	COG2807	transmembrane transport
X953_RS06475	COG2186	Transcriptional regulator
X953_RS06490	COG0745	RESPONSE REGULATOR receiver
X953_RS06505	COG2205	protein histidine kinase activity
X953_RS06525	COG2353	YceI-like domain
X953_RS06535	COG0346	lactoylglutathione lyase activity
X953_RS06540	COG0346	lactoylglutathione lyase activity
X953_RS06545	COG1846	Transcriptional regulator
X953_RS06550	COG0726	polysaccharide deacetylase
X953_RS06565	COG0456	acetyltransferase
X953_RS06615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X953_RS06620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
X953_RS06625	COG2376	Dihydroxyacetone kinase
X953_RS06630	COG1461	Dihydroxyacetone kinase
X953_RS06635	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
X953_RS06675	COG3279	Response regulator of the LytR AlgR family
X953_RS06680	COG1695	Transcriptional regulator
X953_RS06690	COG0535	radical SAM domain protein
X953_RS06700	COG2169	Transcriptional regulator
X953_RS06705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
X953_RS06710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
X953_RS06720	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
X953_RS06750	COG3408	Glycogen debranching enzyme
X953_RS06750	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
X953_RS06760	COG2031	fatty acid transporter
X953_RS06780	COG0494	nUDIX hydrolase
X953_RS06785	COG1061	Type III restriction enzyme res subunit
X953_RS06790	COG1061	Type III restriction enzyme res subunit
X953_RS06800	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS06825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X953_RS06930	COG3655	Transcriptional regulator
X953_RS06935	COG3739	integral membrane protein
X953_RS06955	COG0406	alpha-ribazole phosphatase activity
X953_RS06960	COG0842	Transport permease protein
X953_RS06965	COG1131	(ABC) transporter
X953_RS06980	COG1619	proteins homologs of microcin C7 resistance protein MccF
X953_RS07000	COG0488	(ABC) transporter
X953_RS07010	COG3588	fructose-bisphosphate aldolase
X953_RS07020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X953_RS07030	COG0179	Fumarylacetoacetate (FAA) hydrolase
X953_RS07040	COG4443	Transcriptional Coactivator p15 (PC4)
X953_RS07080	COG1098	S1 RNA binding domain
X953_RS07085	COG2112	serine threonine protein kinase
X953_RS07090	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS07100	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS07110	COG3844	kynureninase activity
X953_RS07115	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
X953_RS07125	COG0733	neurotransmitter:sodium symporter activity
X953_RS07130	COG0745	RESPONSE REGULATOR receiver
X953_RS07145	COG0501	Belongs to the peptidase M48B family
X953_RS07170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
X953_RS07175	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
X953_RS07175	COG0456	acetyltransferase
X953_RS07195	COG0667	Aldo Keto reductase
X953_RS07200	COG3328	transposase activity
X953_RS07210	COG2322	membrane
X953_RS07215	COG2226	methyltransferase
X953_RS07255	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_RS07265	COG1309	transcriptional regulator
X953_RS07270	COG2814	Major facilitator Superfamily
X953_RS07280	COG2217	Heavy metal translocating P-type atpase
X953_RS07295	COG1196	nuclear chromosome segregation
X953_RS07295	COG0741	lytic transglycosylase activity
X953_RS07295	COG0739	heme binding
X953_RS07300	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
X953_RS07305	COG2059	Chromate
X953_RS07310	COG2059	Chromate
X953_RS07320	COG1309	transcriptional regulator
X953_RS07350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X953_RS07370	COG1063	alcohol dehydrogenase
X953_RS07420	COG1368	sulfuric ester hydrolase activity
X953_RS07425	COG0640	Transcriptional regulator
X953_RS07430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
X953_RS07435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
X953_RS07440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
X953_RS07445	COG0598	Magnesium transport protein CorA
X953_RS07455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X953_RS07455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X953_RS07460	COG0307	riboflavin synthase, alpha
X953_RS07465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
X953_RS07465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
X953_RS07470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
X953_RS07485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
X953_RS07490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
X953_RS07515	COG5002	protein histidine kinase activity
X953_RS07520	COG0745	RESPONSE REGULATOR receiver
X953_RS07530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
X953_RS07535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X953_RS07545	COG1533	DNA photolyase activity
X953_RS07630	COG3311	Transcriptional regulator
X953_RS07635	COG0659	secondary active sulfate transmembrane transporter activity
X953_RS07645	COG4990	cell redox homeostasis
X953_RS07660	COG2329	Antibiotic biosynthesis monooxygenase
X953_RS07665	COG2202	Pas domain
X953_RS07665	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_RS07685	COG2314	TM2 domain
X953_RS07690	COG1615	UPF0182 protein
X953_RS07705	COG5504	Zn-dependent protease
X953_RS07720	COG0482	sulfurtransferase activity
X953_RS07725	COG3104	oligopeptide transport
X953_RS07755	COG4294	response to UV
X953_RS07760	COG0517	IMP dehydrogenase activity
X953_RS07795	COG2081	HI0933 family
X953_RS07805	COG1187	pseudouridine synthase activity
X953_RS07820	COG0510	thiamine kinase activity
X953_RS07830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
X953_RS07835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_RS07845	COG1363	Peptidase, m42
X953_RS07850	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
X953_RS07865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_RS07870	COG4848	Belongs to the UPF0354 family
X953_RS07875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X953_RS07880	COG1674	ftsk spoiiie
X953_RS07890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
X953_RS07900	COG4980	gas vesicle protein
X953_RS07905	COG1605	Chorismate mutase
X953_RS07905	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
X953_RS07925	COG0123	including yeast histone deacetylase and acetoin utilization protein
X953_RS07930	COG0517	IMP dehydrogenase activity
X953_RS07935	COG0454	-acetyltransferase
X953_RS07940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X953_RS07945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
X953_RS07950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
X953_RS07955	COG2203	Gaf domain
X953_RS07955	COG2199	diguanylate cyclase activity
X953_RS07960	COG1956	GAF domain-containing protein
X953_RS07965	COG1309	transcriptional regulator
X953_RS07970	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
X953_RS07975	COG1104	cysteine desulfurase activity
X953_RS07980	COG0301	tRNA thio-modification
X953_RS07990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
X953_RS08000	COG3874	Sporulation protein YtfJ
X953_RS08005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
X953_RS08010	COG0827	DNA restriction-modification system
X953_RS08015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
X953_RS08020	COG0521	Mo-molybdopterin cofactor biosynthetic process
X953_RS08025	COG0589	response to stress
X953_RS08035	COG1842	Phage shock protein A
X953_RS08050	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
X953_RS08055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
X953_RS08075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
X953_RS08085	COG1459	type II secretion system
X953_RS08095	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
X953_RS08120	COG4109	DRTGG domain
X953_RS08130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
X953_RS08150	COG0587	DNA-directed DNA polymerase activity
X953_RS08155	COG0281	malic enzyme
X953_RS08160	COG2186	Transcriptional regulator
X953_RS08165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
X953_RS08170	COG0825	malonyl-CoA metabolic process
X953_RS08175	COG0205	6-phosphofructokinase activity
X953_RS08185	COG3030	protein affecting phage T7 exclusion by the F plasmid
X953_RS08190	COG0628	permease
X953_RS08195	COG0372	Belongs to the citrate synthase family
X953_RS08200	COG0538	isocitrate dehydrogenase activity
X953_RS08205	COG0039	L-malate dehydrogenase activity
X953_RS08215	COG0745	RESPONSE REGULATOR receiver
X953_RS08220	COG5002	protein histidine kinase activity
X953_RS08225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
X953_RS08225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
X953_RS08235	COG0237	dephospho-CoA kinase activity
X953_RS08240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
X953_RS08245	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
X953_RS08255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
X953_RS08260	COG3611	Membrane attachment protein
X953_RS08265	COG1484	DNA-dependent DNA replication
X953_RS08275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
X953_RS08280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
X953_RS08285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
X953_RS08290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
X953_RS08295	COG3326	Membrane
X953_RS08300	COG0398	Pfam SNARE associated Golgi protein
X953_RS08315	COG1363	Peptidase, m42
X953_RS08320	COG0741	lytic transglycosylase activity
X953_RS08325	COG1131	(ABC) transporter
X953_RS08350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X953_RS08360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X953_RS08360	COG0072	phenylalanine-tRNA ligase activity
X953_RS08365	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
X953_RS08370	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
X953_RS08375	COG1286	toxin biosynthetic process
X953_RS08380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
X953_RS08380	COG1796	DNA polymerase
X953_RS08385	COG1193	negative regulation of DNA recombination
X953_RS08390	COG3766	membrane
X953_RS08395	COG0318	PFAM AMP-dependent synthetase and ligase
X953_RS08400	COG1309	transcriptional regulator
X953_RS08405	COG1024	Enoyl-CoA hydratase
X953_RS08410	COG2086	electron transfer activity
X953_RS08415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
X953_RS08420	COG3118	belongs to the thioredoxin family
X953_RS08425	COG0322	excinuclease ABC activity
X953_RS08430	COG1719	4-vinyl reductase, 4VR
X953_RS08435	COG2009	succinate dehydrogenase
X953_RS08440	COG1053	succinate dehydrogenase
X953_RS08445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
X953_RS08450	COG0824	Thioesterase
X953_RS08455	COG2197	response regulator
X953_RS08460	COG1846	Transcriptional regulator
X953_RS08465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
X953_RS08470	COG5401	PFAM Sporulation and spore germination
X953_RS08475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
X953_RS08480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
X953_RS08485	COG0622	Phosphoesterase
X953_RS08500	COG1477	protein flavinylation
X953_RS08500	COG0457	Tetratricopeptide repeat
X953_RS08505	COG0544	peptidyl-prolyl cis-trans isomerase activity
X953_RS08510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
X953_RS08520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
X953_RS08530	COG0765	amino acid transport
X953_RS08545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
X953_RS08550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
X953_RS08555	COG0181	hydroxymethylbilane synthase activity
X953_RS08570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
X953_RS08575	COG1388	LysM domain
X953_RS08575	COG1388	LysM domain
X953_RS08590	COG0525	valine-tRNA ligase activity
X953_RS08600	COG0189	ligase activity
X953_RS08605	COG0285	dihydrofolate synthase activity
X953_RS08615	COG2003	Belongs to the UPF0758 family
X953_RS08625	COG1077	Cell shape determining protein MreB Mrl
X953_RS08640	COG0850	regulation of cytokinetic process
X953_RS08645	COG2894	cell division
X953_RS08655	COG1994	Peptidase M50
X953_RS08660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
X953_RS08665	COG2868	ribosomal protein
X953_RS08680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
X953_RS08685	COG0077	Prephenate dehydratase
X953_RS08700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
X953_RS08710	COG0217	transcriptional regulatory protein
X953_RS08715	COG0632	four-way junction helicase activity
X953_RS08720	COG2255	four-way junction helicase activity
X953_RS08730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
X953_RS08735	COG0343	queuine tRNA-ribosyltransferase activity
X953_RS08740	COG1862	Preprotein translocase
X953_RS08750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
X953_RS08755	COG2244	polysaccharide biosynthetic process
X953_RS08765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X953_RS08765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X953_RS08770	COG5416	Lipopolysaccharide assembly protein A domain
X953_RS08775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
X953_RS08775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
X953_RS08780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
X953_RS08785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X953_RS08790	COG1490	D-aminoacyl-tRNA deacylase activity
X953_RS08795	COG0860	N-Acetylmuramoyl-L-alanine amidase
X953_RS08795	COG4991	sh3 domain protein
X953_RS08795	COG3103	Sh3 type 3 domain protein
X953_RS08800	COG0124	histidyl-tRNA synthetase
X953_RS08805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
X953_RS08815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
X953_RS08820	COG1959	2 iron, 2 sulfur cluster binding
X953_RS08825	COG1104	cysteine desulfurase activity
X953_RS08830	COG0482	sulfurtransferase activity
X953_RS08840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
X953_RS08855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
X953_RS08860	COG4472	Bacterial protein of unknown function (DUF965)
X953_RS08865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
X953_RS08870	COG3906	Belongs to the UPF0473 family
X953_RS08880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
X953_RS08885	COG4122	O-methyltransferase activity
X953_RS08890	COG0572	uridine kinase
X953_RS08895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X953_RS08905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
X953_RS08920	COG1320	monovalent cation:proton antiporter activity
X953_RS08925	COG2212	antiporter activity
X953_RS08930	COG1863	multisubunit Na H antiporter MnhE subunit
X953_RS08935	COG0651	ATP synthesis coupled electron transport
X953_RS08940	COG1006	Multisubunit Na H antiporter MnhC subunit
X953_RS08945	COG2111	Na H antiporter
X953_RS08945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
X953_RS08955	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
X953_RS08960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
X953_RS08965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
X953_RS08970	COG1534	Rna-binding protein
X953_RS08975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
X953_RS08980	COG1713	HD superfamily hydrolase involved in NAD metabolism
X953_RS08985	COG0799	negative regulation of ribosome biogenesis
X953_RS08990	COG2226	methyltransferase
X953_RS08995	COG1596	polysaccharide export
X953_RS08995	COG1555	photosystem II stabilization
X953_RS09000	COG2131	deaminase
X953_RS09005	COG2333	competence protein COMEC
X953_RS09005	COG0658	competence protein
X953_RS09015	COG1466	dna polymerase III delta subunit
X953_RS09020	COG0268	Binds directly to 16S ribosomal RNA
X953_RS09025	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
X953_RS09030	COG0860	N-Acetylmuramoyl-L-alanine amidase
X953_RS09040	COG0481	GTPase activity
X953_RS09045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X953_RS09050	COG1420	regulation of RNA biosynthetic process
X953_RS09055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
X953_RS09060	COG0443	Heat shock 70 kDa protein
X953_RS09065	COG0484	heat shock protein binding
X953_RS09070	COG2264	protein methyltransferase activity
X953_RS09075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
X953_RS09080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
X953_RS09085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
X953_RS09090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
X953_RS09095	COG1610	YqeY-like protein
X953_RS09100	COG1030	water channel activity
X953_RS09105	COG4864	UPF0365 protein
X953_RS09125	COG1702	phosphate starvation-inducible protein PhoH
X953_RS09130	COG1480	7TM receptor with intracellular HD hydrolase
X953_RS09135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
X953_RS09145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
X953_RS09150	COG1381	Involved in DNA repair and RecF pathway recombination
X953_RS09155	COG0752	glycyl-tRNA synthetase alpha subunit
X953_RS09160	COG0751	glycine-tRNA ligase activity
X953_RS09165	COG0517	IMP dehydrogenase activity
X953_RS09170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
X953_RS09175	COG0358	DNA primase activity
X953_RS09180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
X953_RS09195	COG2384	SAM-dependent methyltransferase
X953_RS09200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
X953_RS09210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
X953_RS09220	COG4709	membrane
X953_RS09270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
X953_RS09275	COG0477	Major facilitator Superfamily
X953_RS09280	COG0768	penicillin binding
X953_RS09285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
X953_RS09295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
X953_RS09300	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
X953_RS09305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
X953_RS09310	COG0705	Rhomboid family
X953_RS09310	COG0457	Tetratricopeptide repeat
X953_RS09320	COG0697	spore germination
X953_RS09330	COG1940	carbohydrate kinase activity
X953_RS09335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_RS09480	COG2433	Pfam Transposase IS66
X953_RS09530	COG0582	viral genome integration into host DNA
X953_RS09610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X953_RS09615	COG4537	Required for transformation and DNA binding
X953_RS09625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
X953_RS09640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
X953_RS09645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
X953_RS09650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
X953_RS09655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
X953_RS09660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_RS09665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X953_RS09670	COG1321	iron dependent repressor
X953_RS09675	COG1752	Esterase of the alpha-beta hydrolase superfamily
X953_RS09690	COG0006	proline dipeptidase activity
X953_RS09695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
X953_RS09700	COG3854	ATPases associated with a variety of cellular activities
X953_RS09740	COG0511	ligase activity, forming carbon-carbon bonds
X953_RS09745	COG0439	Biotin carboxylase
X953_RS09750	COG1302	Protein conserved in bacteria
X953_RS09755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X953_RS09760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
X953_RS09765	COG1570	exodeoxyribonuclease VII activity
X953_RS09770	COG1722	exodeoxyribonuclease VII activity
X953_RS09785	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
X953_RS09790	COG1438	arginine binding
X953_RS09795	COG0497	DNA recombination
X953_RS09800	COG0750	zinc metalloprotease
X953_RS09805	COG0745	RESPONSE REGULATOR receiver
X953_RS09810	COG0527	aspartate kinase activity
X953_RS09820	COG3290	protein histidine kinase activity
X953_RS09820	COG3829	transcription factor binding
X953_RS09825	COG0280	phosphate acetyltransferase
X953_RS09835	COG3426	butyrate kinase activity
X953_RS09840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X953_RS09845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
X953_RS09850	COG0022	dehydrogenase e1 component
X953_RS09855	COG0508	dehydrogenase complex catalyzes the overall conversion of
X953_RS09865	COG4129	membrane
X953_RS09870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
X953_RS09870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
X953_RS09875	COG0346	lactoylglutathione lyase activity
X953_RS09880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
X953_RS09885	COG2195	Cleaves the N-terminal amino acid of tripeptides
X953_RS09890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
X953_RS09895	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS09900	COG1234	tRNA 3'-trailer cleavage
X953_RS09905	COG1902	pentaerythritol trinitrate reductase activity
X953_RS09910	COG0584	glycerophosphoryl diester phosphodiesterase
X953_RS09915	COG4187	Peptidase family M20/M25/M40
X953_RS09920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_RS09925	COG0300	oxidoreductase activity
X953_RS09935	COG0667	Aldo Keto reductase
X953_RS09945	COG1379	DNA repair
X953_RS09950	COG1300	Membrane
X953_RS09955	COG0735	belongs to the Fur family
X953_RS09965	COG4974	Belongs to the 'phage' integrase family
X953_RS09970	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
X953_RS09990	COG1686	Belongs to the peptidase S11 family
X953_RS09995	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_RS10000	COG2172	sigma factor antagonist activity
X953_RS10020	COG0697	spore germination
X953_RS10025	COG0019	diaminopimelate decarboxylase activity
X953_RS10030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
X953_RS10035	COG0750	zinc metalloprotease
X953_RS10050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
X953_RS10055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
X953_RS10060	COG1686	Belongs to the peptidase S11 family
X953_RS10065	COG2715	membrane protein required for spore maturation
X953_RS10070	COG0700	Nucleoside recognition
X953_RS10075	COG1187	pseudouridine synthase activity
X953_RS10080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_RS10085	COG1333	cytochrome c biogenesis protein
X953_RS10090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
X953_RS10095	COG0745	RESPONSE REGULATOR receiver
X953_RS10100	COG5002	protein histidine kinase activity
X953_RS10110	COG1141	Ferredoxin
X953_RS10115	COG4955	Helix-turn-helix domain
X953_RS10120	COG0514	ATP-dependent DNA helicase (RecQ)
X953_RS10125	COG1266	CAAX protease self-immunity
X953_RS10135	COG1408	metallophosphoesterase
X953_RS10140	COG4862	establishment of competence for transformation
X953_RS10145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
X953_RS10150	COG0492	ferredoxin-NADP+ reductase activity
X953_RS10155	COG0252	asparaginase activity
X953_RS10160	COG2339	peptidase activity
X953_RS10165	COG3409	Peptidoglycan-binding domain 1 protein
X953_RS10165	COG3773	Cell wall hydrolase
X953_RS10170	COG2959	enzyme of heme biosynthesis
X953_RS10185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
X953_RS10195	COG0539	negative regulation of cytoplasmic translation
X953_RS10215	COG1160	GTP binding
X953_RS10220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
X953_RS10240	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
X953_RS10245	COG0776	regulation of translation
X953_RS10260	COG2226	methyltransferase
X953_RS10265	COG0142	geranyltranstransferase activity
X953_RS10270	COG0105	UTP biosynthetic process
X953_RS10275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
X953_RS10280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
X953_RS10285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
X953_RS10290	COG4401	Chorismate mutase type I
X953_RS10295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X953_RS10300	COG0287	Prephenate dehydrogenase
X953_RS10305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X953_RS10315	COG5582	Belongs to the UPF0302 family
X953_RS10325	COG0723	plastoquinol--plastocyanin reductase activity
X953_RS10330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
X953_RS10340	COG4347	Protein of unknown function (DUF1405)
X953_RS10350	COG2738	Putative neutral zinc metallopeptidase
X953_RS10355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_RS10360	COG1694	Mazg nucleotide pyrophosphohydrolase
X953_RS10365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
X953_RS10370	COG1803	Methylglyoxal synthase
X953_RS10375	COG0438	transferase activity, transferring glycosyl groups
X953_RS10380	COG0617	tRNA 3'-terminal CCA addition
X953_RS10395	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
X953_RS10400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
X953_RS10405	COG1199	ATP-dependent helicase activity
X953_RS10405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
X953_RS10415	COG0436	Aminotransferase
X953_RS10420	COG0017	Asparaginyl-tRNA synthetase
X953_RS10425	COG3935	DnaD domain protein
X953_RS10430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
X953_RS10435	COG4499	WXG100 protein secretion system (Wss), protein YukC
X953_RS10435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X953_RS10440	COG3331	DNA recombination
X953_RS10460	COG0295	cytidine deaminase activity
X953_RS10465	COG3599	regulation of cell shape
X953_RS10470	COG0116	Belongs to the methyltransferase superfamily
X953_RS10475	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
X953_RS10480	COG3424	synthase
X953_RS10485	COG1755	Isoprenylcysteine carboxyl methyltransferase
X953_RS10490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X953_RS10495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
X953_RS10510	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
X953_RS10525	COG1418	mRNA catabolic process
X953_RS10530	COG0791	NLP P60 protein
X953_RS10530	COG1388	LysM domain
X953_RS10535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
X953_RS10540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
X953_RS10550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X953_RS10555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X953_RS10560	COG0805	protein transport
X953_RS10565	COG4479	Belongs to the UPF0346 family
X953_RS10580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X953_RS10580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X953_RS10600	COG1254	Belongs to the acylphosphatase family
X953_RS10620	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
X953_RS10625	COG1140	nitrate reductase beta subunit
X953_RS10635	COG2181	nitrate reductase activity
X953_RS10640	COG0723	plastoquinol--plastocyanin reductase activity
X953_RS10640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_RS10645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X953_RS10650	COG0723	plastoquinol--plastocyanin reductase activity
X953_RS10650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_RS10655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
X953_RS10660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
X953_RS10665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
X953_RS10670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
X953_RS10675	COG1024	Enoyl-CoA hydratase
X953_RS10680	COG0511	ligase activity, forming carbon-carbon bonds
X953_RS10685	COG0439	Biotin carboxylase
X953_RS10690	COG0318	PFAM AMP-dependent synthetase and ligase
X953_RS10695	COG1960	acyl-CoA dehydrogenase activity
X953_RS10700	COG1309	transcriptional regulator
X953_RS10705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
X953_RS10710	COG0187	DNA topoisomerase II activity
X953_RS10715	COG1832	CoA-binding protein
X953_RS10720	COG1174	glycine betaine transport
X953_RS10730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
X953_RS10735	COG1469	GTP cyclohydrolase I activity
X953_RS10740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
X953_RS10750	COG0824	Thioesterase
X953_RS10760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_RS10770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
X953_RS10775	COG4191	Histidine kinase
X953_RS10785	COG4846	Membrane protein involved in cytochrome C biogenesis
X953_RS10790	COG2201	protein-glutamate methylesterase activity
X953_RS10795	COG2111	Na H antiporter
X953_RS10800	COG0785	Cytochrome C biogenesis protein
X953_RS10805	COG3763	UPF0154 protein
X953_RS10820	COG4224	UPF0291 protein
X953_RS10825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X953_RS10830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
X953_RS10835	COG0174	glutamine synthetase
X953_RS10840	COG0789	Transcriptional regulator
X953_RS10845	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
X953_RS10850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
X953_RS10855	COG0464	growth
X953_RS10860	COG1923	regulation of RNA biosynthetic process
X953_RS10865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
X953_RS10870	COG0783	Belongs to the Dps family
X953_RS10875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
X953_RS10880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
X953_RS10890	COG4550	Control of competence regulator ComK, YlbF/YmcA
X953_RS10895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
X953_RS10900	COG2359	stage V sporulation protein S
X953_RS10905	COG1692	metallophosphoesterase
X953_RS10910	COG1418	mRNA catabolic process
X953_RS10915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
X953_RS10920	COG1546	Belongs to the CinA family
X953_RS10920	COG1058	Belongs to the CinA family
X953_RS10925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
X953_RS10930	COG1426	Protein conserved in bacteria
X953_RS10945	COG0300	oxidoreductase activity
X953_RS10950	COG0612	Peptidase, M16
X953_RS10955	COG0612	Peptidase, M16
X953_RS10960	COG1079	Belongs to the binding-protein-dependent transport system permease family
X953_RS10965	COG4603	Belongs to the binding-protein-dependent transport system permease family
X953_RS10970	COG3845	ABC transporter
X953_RS10975	COG1744	ABC transporter substrate-binding protein PnrA-like
X953_RS10980	COG2188	Transcriptional regulator
X953_RS10985	COG1674	ftsk spoiiie
X953_RS10995	COG0740	serine-type endopeptidase activity
X953_RS11000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X953_RS11005	COG0527	aspartate kinase activity
X953_RS11010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
X953_RS11015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
X953_RS11020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X953_RS11025	COG1873	PFAM PRC-barrel domain
X953_RS11030	COG0612	Peptidase, M16
X953_RS11035	COG0726	polysaccharide deacetylase
X953_RS11050	COG1185	polyribonucleotide nucleotidyltransferase activity
X953_RS11055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
X953_RS11060	COG0196	riboflavin kinase activity
X953_RS11065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
X953_RS11070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
X953_RS11080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
X953_RS11085	COG1358	cellular component organization or biogenesis
X953_RS11090	COG2740	Nucleic-acid-binding protein implicated in transcription termination
X953_RS11095	COG0195	Participates in both transcription termination and antitermination
X953_RS11100	COG0779	Required for maturation of 30S ribosomal subunits
X953_RS11105	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_RS11110	COG2176	DNA-directed DNA polymerase activity
X953_RS11115	COG0750	zinc metalloprotease
X953_RS11120	COG4589	Belongs to the CDS family
X953_RS11125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
X953_RS11135	COG0233	cytoplasmic translational termination
X953_RS11140	COG0528	UMP kinase activity
X953_RS11145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
X953_RS11150	COG0052	Belongs to the universal ribosomal protein uS2 family
X953_RS11170	COG1191	sigma factor activity
X953_RS11175	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
X953_RS11180	COG1776	CheC inhibitor of MCP methylation
X953_RS11185	COG0835	chemotaxis
X953_RS11190	COG2201	protein-glutamate methylesterase activity
X953_RS11195	COG0455	bacterial-type flagellum organization
X953_RS11200	COG1419	protein localization to endoplasmic reticulum
X953_RS11205	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X953_RS11210	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X953_RS11215	COG1684	flagellar biosynthetic protein fliR
X953_RS11220	COG1987	bacterial-type flagellum assembly
X953_RS11225	COG1338	Plays a role in the flagellum-specific transport system
X953_RS11230	COG3190	flagellar
X953_RS11235	COG2201	protein-glutamate methylesterase activity
X953_RS11240	COG1776	CheC inhibitor of MCP methylation
X953_RS11240	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
X953_RS11245	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
X953_RS11250	COG1580	Controls the rotational direction of flagella during chemotaxis
X953_RS11255	COG1582	Flagellar protein (FlbD)
X953_RS11260	COG4786	Flagellar basal body rod
X953_RS11270	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
X953_RS11290	COG1157	protein secretion by the type III secretion system
X953_RS11300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
X953_RS11305	COG1766	The M ring may be actively involved in energy transduction
X953_RS11310	COG1677	Flagellar hook-basal body complex protein FliE
X953_RS11315	COG1558	bacterial-type flagellum-dependent cell motility
X953_RS11320	COG1815	bacterial-type flagellum-dependent cell motility
X953_RS11325	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
X953_RS11330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
X953_RS11335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
X953_RS11340	COG4974	Belongs to the 'phage' integrase family
X953_RS11350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
X953_RS11355	COG0758	DNA mediated transformation
X953_RS11360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
X953_RS11365	COG0045	succinate-CoA ligase (ADP-forming) activity
X953_RS11370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X953_RS11380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
X953_RS11385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
X953_RS11395	COG0335	large ribosomal subunit rRNA binding
X953_RS11400	COG0336	Belongs to the RNA methyltransferase TrmD family
X953_RS11405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
X953_RS11415	COG1837	Belongs to the UPF0109 family
X953_RS11420	COG0228	four-way junction DNA binding
X953_RS11425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
X953_RS11430	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
X953_RS11435	COG0552	protein localization to endoplasmic reticulum
X953_RS11440	COG1196	nuclear chromosome segregation
X953_RS11445	COG4840	Belongs to the UPF0435 family
X953_RS11450	COG0571	ribonuclease III activity
X953_RS11455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
X953_RS11460	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS11465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
X953_RS11470	COG0416	fatty acid biosynthetic process
X953_RS11475	COG1349	DNA-binding transcription factor activity
X953_RS11480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
X953_RS11485	COG1760	l-serine dehydratase
X953_RS11490	COG1760	l-serine dehydratase
X953_RS11500	COG1461	Dihydroxyacetone kinase
X953_RS11505	COG1302	Protein conserved in bacteria
X953_RS11510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
X953_RS11520	COG1564	THIamine pyrophosphokinase
X953_RS11525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
X953_RS11530	COG1162	GTPase activity
X953_RS11535	COG2815	serine threonine protein kinase
X953_RS11535	COG0515	serine threonine protein kinase
X953_RS11540	COG0631	protein serine/threonine phosphatase activity
X953_RS11545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
X953_RS11545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X953_RS11550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
X953_RS11555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
X953_RS11560	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
X953_RS11565	COG1758	RNA polymerase activity
X953_RS11570	COG0194	GDP metabolic process
X953_RS11575	COG2052	Domain of unknown function (DUF370)
X953_RS11580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
X953_RS11590	COG1764	response to oxidative stress
X953_RS11595	COG0583	DNA-binding transcription factor activity
X953_RS11600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
X953_RS11605	COG0284	orotidine-5'-phosphate decarboxylase activity
X953_RS11610	COG0167	dihydroorotate dehydrogenase activity
X953_RS11615	COG0543	2 iron, 2 sulfur cluster binding
X953_RS11620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
X953_RS11625	COG0505	Belongs to the CarA family
X953_RS11635	COG0540	Belongs to the ATCase OTCase family
X953_RS11640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
X953_RS11645	COG0564	pseudouridine synthase activity
X953_RS11650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
X953_RS11655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
X953_RS11660	COG3599	regulation of cell shape
X953_RS11665	COG2302	S4 RNA-binding domain
X953_RS11670	COG1799	cell septum assembly
X953_RS11675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
X953_RS11680	COG1496	oxidoreductase activity
X953_RS11685	COG1873	PFAM PRC-barrel domain
X953_RS11690	COG1191	sigma factor activity
X953_RS11695	COG1191	sigma factor activity
X953_RS11705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
X953_RS11710	COG0849	cell division
X953_RS11715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
X953_RS11720	COG0772	Belongs to the SEDS family
X953_RS11725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
X953_RS11730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X953_RS11735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
X953_RS11740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
X953_RS11745	COG0768	penicillin binding
X953_RS11750	COG0768	penicillin binding
X953_RS11755	COG4839	cell division protein FtsL
X953_RS11760	COG0275	rRNA processing
X953_RS11765	COG2001	Belongs to the MraZ family
X953_RS11770	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
X953_RS11780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X953_RS11785	COG0454	-acetyltransferase
X953_RS11795	COG1024	Enoyl-CoA hydratase
X953_RS11800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
X953_RS11810	COG1323	Belongs to the UPF0348 family
X953_RS11815	COG3480	Lon protease (S16) C-terminal proteolytic domain
X953_RS11820	COG3314	Sporulation integral membrane protein YlbJ
X953_RS11825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
X953_RS11830	COG0742	ribosomal rna small subunit methyltransferase
X953_RS11835	COG4471	UPF0298 protein
X953_RS11840	COG3679	Belongs to the UPF0342 family
X953_RS11855	COG2340	Cysteine-rich secretory protein family
X953_RS11870	COG2322	membrane
X953_RS11875	COG3336	cytochrome c oxidase
X953_RS11885	COG1845	cytochrome c oxidase, subunit III
X953_RS11890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X953_RS11900	COG0109	protoheme IX farnesyltransferase activity
X953_RS11905	COG1612	heme a metabolic process
X953_RS11910	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
X953_RS11915	COG0772	Belongs to the SEDS family
X953_RS11920	COG4838	Belongs to the UPF0358 family
X953_RS11925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
X953_RS11940	COG4896	Protein conserved in bacteria
X953_RS11950	COG0483	inositol monophosphate 1-phosphatase activity
X953_RS11960	COG4493	Belongs to the UPF0637 family
X953_RS11965	COG4476	Belongs to the UPF0223 family
X953_RS11975	COG1982	Orn Lys Arg decarboxylase major
X953_RS12010	COG0022	dehydrogenase e1 component
X953_RS12020	COG0497	DNA recombination
X953_RS12025	COG0242	peptide deformylase activity
X953_RS12030	COG0561	phosphatase activity
X953_RS12035	COG5503	Protein of unknown function (DUF1447)
X953_RS12040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
X953_RS12045	COG0028	Belongs to the TPP enzyme family
X953_RS12050	COG0569	domain protein
X953_RS12055	COG1132	(ABC) transporter
X953_RS12065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_RS12070	COG0450	alkyl hydroperoxide reductase
X953_RS12080	COG1473	amidohydrolase
X953_RS12085	COG2171	N-acyltransferase activity
X953_RS12090	COG0517	IMP dehydrogenase activity
X953_RS12095	COG0640	Transcriptional regulator
X953_RS12110	COG1408	metallophosphoesterase
X953_RS12130	COG0697	spore germination
X953_RS12135	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
X953_RS12140	COG0436	Aminotransferase
X953_RS12145	COG0681	Belongs to the peptidase S26 family
X953_RS12155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X953_RS12160	COG3835	regulator
X953_RS12175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X953_RS12180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
X953_RS12190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X953_RS12195	COG0303	'Molybdopterin
X953_RS12220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
X953_RS12235	COG2323	membrane
X953_RS12240	COG1301	dicarboxylic acid transport
X953_RS12245	COG0604	alcohol dehydrogenase
X953_RS12250	COG0003	Pfam Anion-transporting ATPase
X953_RS12260	COG1966	Carbon starvation protein
X953_RS12265	COG2427	Protein of unknown function (DUF1641)
X953_RS12270	COG3383	formate dehydrogenase (NAD+) activity
X953_RS12280	COG3069	C4-dicarboxylate transmembrane transporter activity
X953_RS12290	COG3859	Proton-coupled thiamine transporter YuaJ
X953_RS12295	COG2353	YceI-like domain
X953_RS12300	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
X953_RS12325	COG1252	NADH dehydrogenase
X953_RS12340	COG0318	PFAM AMP-dependent synthetase and ligase
X953_RS12375	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
X953_RS12390	COG1725	Transcriptional regulator
X953_RS12410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
X953_RS12415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
X953_RS12425	COG1917	Cupin 2, conserved barrel domain protein
X953_RS12430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
X953_RS12445	COG1174	glycine betaine transport
X953_RS12450	COG1732	Glycine betaine
X953_RS12455	COG1174	glycine betaine transport
X953_RS12465	COG1510	regulation of RNA biosynthetic process
X953_RS12475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X953_RS12485	COG0402	S-adenosylhomocysteine deaminase activity
X953_RS12490	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
X953_RS12515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_RS12525	COG0495	leucyl-tRNA aminoacylation
X953_RS12530	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
X953_RS12535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
X953_RS12540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
X953_RS12545	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
X953_RS12550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X953_RS12555	COG1116	anion transmembrane transporter activity
X953_RS12560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X953_RS12565	COG0494	nUDIX hydrolase
X953_RS12580	COG1120	ATPase activity
X953_RS12585	COG0318	PFAM AMP-dependent synthetase and ligase
X953_RS12590	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
X953_RS12595	COG0596	Alpha beta hydrolase
X953_RS12600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
X953_RS12605	COG1169	isochorismate synthase
X953_RS12610	COG1575	Belongs to the MenA family. Type 1 subfamily
X953_RS12615	COG2050	protein possibly involved in aromatic compounds catabolism
X953_RS12620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
X953_RS12625	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
X953_RS12630	COG1404	Belongs to the peptidase S8 family
X953_RS12630	COG4412	M6 family metalloprotease domain protein
X953_RS12645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
X953_RS12655	COG1098	S1 RNA binding domain
X953_RS12660	COG2155	Conserved Protein
X953_RS12665	COG0166	Belongs to the GPI family
X953_RS12670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
X953_RS12675	COG2032	superoxide dismutase activity
X953_RS12690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_RS12695	COG0813	purine-nucleoside phosphorylase activity
X953_RS12700	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
X953_RS12705	COG3584	3D domain protein
X953_RS12715	COG1252	NADH dehydrogenase
X953_RS12720	COG0492	ferredoxin-NADP+ reductase activity
X953_RS12725	COG0316	Belongs to the HesB IscA family
X953_RS12730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
X953_RS12735	COG4837	Protein of unknown function (DUF1462)
X953_RS12740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
X953_RS12745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X953_RS12750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
X953_RS12755	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
X953_RS12760	COG0647	UMP catabolic process
X953_RS12770	COG2445	Protein of unknown function DUF86
X953_RS12780	COG0154	amidase activity
X953_RS12790	COG4470	Protein conserved in bacteria
X953_RS12800	COG0739	heme binding
X953_RS12805	COG0733	neurotransmitter:sodium symporter activity
X953_RS12810	COG1757	Na H antiporter
X953_RS12820	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
X953_RS12825	COG3377	Domain of unknown function (DUF1805)
X953_RS12830	COG0737	Belongs to the 5'-nucleotidase family
X953_RS12835	COG0730	response to heat
X953_RS12840	COG0719	Fe-S assembly protein
X953_RS12845	COG0822	iron-sulfur transferase activity
X953_RS12850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
X953_RS12855	COG0719	Fe-S assembly protein
X953_RS12860	COG0396	ATPase activity
X953_RS12865	COG1464	Belongs to the NlpA lipoprotein family
X953_RS12870	COG2011	ABC-type metal ion transport system permease component
X953_RS12875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
X953_RS12880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_RS12885	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
X953_RS12890	COG0509	glycine decarboxylation via glycine cleavage system
X953_RS12895	COG1393	Belongs to the ArsC family
X953_RS12900	COG1960	acyl-CoA dehydrogenase activity
X953_RS12905	COG0183	Belongs to the thiolase family
X953_RS12910	COG1250	3-hydroxyacyl-CoA dehydrogenase
X953_RS12910	COG1024	Enoyl-CoA hydratase
X953_RS12915	COG0506	proline dehydrogenase activity
X953_RS12925	COG2217	Heavy metal translocating P-type atpase
X953_RS12930	COG1937	Protein conserved in bacteria
X953_RS12940	COG1121	(ABC) transporter
X953_RS12945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X953_RS12960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
X953_RS12975	COG3883	PFAM NLP P60 protein
X953_RS12975	COG0791	NLP P60 protein
X953_RS12980	COG2224	Isocitrate lyase
X953_RS12985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
X953_RS12990	COG4129	membrane
X953_RS12995	COG2197	response regulator
X953_RS13000	COG4585	Histidine kinase
X953_RS13005	COG4758	membrane
X953_RS13020	COG2814	Major facilitator Superfamily
X953_RS13025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X953_RS13040	COG1363	Peptidase, m42
X953_RS13045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
X953_RS13050	COG0803	Belongs to the bacterial solute-binding protein 9 family
X953_RS13055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X953_RS13060	COG1121	(ABC) transporter
X953_RS13065	COG0557	exoribonuclease II activity
X953_RS13070	COG1647	Serine aminopeptidase, S33
X953_RS13075	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
X953_RS13100	COG0148	phosphopyruvate hydratase activity
X953_RS13105	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
X953_RS13110	COG0149	triose-phosphate isomerase activity
X953_RS13115	COG0126	phosphoglycerate kinase activity
X953_RS13135	COG0328	RNA-DNA hybrid ribonuclease activity
X953_RS13140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X953_RS13145	COG3162	membrane
X953_RS13150	COG2610	gluconate transmembrane transporter activity
X953_RS13155	COG0183	Belongs to the thiolase family
X953_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS13165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
X953_RS13170	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
X953_RS13195	COG0710	3-dehydroquinate dehydratase activity
X953_RS13200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
X953_RS13210	COG0740	serine-type endopeptidase activity
X953_RS13215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_RS13220	COG1481	regulation of sporulation
X953_RS13225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
X953_RS13230	COG1660	Displays ATPase and GTPase activities
X953_RS13235	COG1051	belongs to the nudix hydrolase family
X953_RS13240	COG0492	ferredoxin-NADP+ reductase activity
X953_RS13245	COG0457	Tetratricopeptide repeat
X953_RS13250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
X953_RS13255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
X953_RS13260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X953_RS13270	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
X953_RS13275	COG0110	maltose O-acetyltransferase activity
X953_RS13280	COG0546	phosphoglycolate phosphatase activity
X953_RS13285	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
X953_RS13290	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
X953_RS13295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
X953_RS13300	COG1950	PFAM Membrane protein of
X953_RS13305	COG1983	PspC domain protein
X953_RS13315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
X953_RS13320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
X953_RS13325	COG0556	nucleotide-excision repair
X953_RS13335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X953_RS13340	COG0793	Belongs to the peptidase S41A family
X953_RS13340	COG3409	Peptidoglycan-binding domain 1 protein
X953_RS13345	COG0739	heme binding
X953_RS13350	COG2177	Part of the ABC transporter FtsEX involved in
X953_RS13355	COG2884	Cell division ATP-binding protein ftsE
X953_RS13365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
X953_RS13370	COG0653	protein targeting
X953_RS13375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
X953_RS13385	COG1516	flagellar protein fliS
X953_RS13390	COG1334	flagellar protein FlaG
X953_RS13395	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
X953_RS13400	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
X953_RS13410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
X953_RS13415	COG1256	bacterial-type flagellum assembly
X953_RS13415	COG4786	Flagellar basal body rod
X953_RS13435	COG1040	competence protein
X953_RS13440	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
X953_RS13445	COG1307	EDD domain protein, DegV family
X953_RS13450	COG2197	response regulator
X953_RS13455	COG4585	Histidine kinase
X953_RS13460	COG1739	Uncharacterized protein family UPF0029
X953_RS13465	COG0363	glucosamine-6-phosphate deaminase activity
X953_RS13470	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
X953_RS13475	COG2190	(PTS) system
X953_RS13475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X953_RS13475	COG1263	PTS System
X953_RS13495	COG0681	Belongs to the peptidase S26 family
X953_RS13515	COG3764	Sortase (surface protein transpeptidase)
X953_RS13520	COG1316	TRANSCRIPTIONal
X953_RS13525	COG0768	penicillin binding
X953_RS13545	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS13555	COG0561	phosphatase activity
X953_RS13560	COG2814	Major facilitator Superfamily
X953_RS13565	COG1984	allophanate hydrolase subunit 2
X953_RS13570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
X953_RS13575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
X953_RS13580	COG0471	metal ion transport
X953_RS13585	COG2814	Major facilitator Superfamily
X953_RS13590	COG2807	transmembrane transport
X953_RS13600	COG1368	sulfuric ester hydrolase activity
X953_RS13605	COG0840	transmembrane signaling receptor activity
X953_RS13610	COG2197	response regulator
X953_RS13615	COG0840	transmembrane signaling receptor activity
X953_RS13625	COG2201	protein-glutamate methylesterase activity
X953_RS13630	COG0835	chemotaxis
X953_RS13635	COG2198	Histidine kinase
X953_RS13635	COG0643	Histidine kinase
X953_RS13645	COG1360	Flagellar Motor Protein
X953_RS13650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
X953_RS13655	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
X953_RS13675	COG0840	transmembrane signaling receptor activity
X953_RS13685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X953_RS13690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
X953_RS13695	COG1472	Belongs to the glycosyl hydrolase 3 family
X953_RS13700	COG3876	Protein conserved in bacteria
X953_RS13705	COG0395	ABC-type sugar transport system, permease component
X953_RS13710	COG1175	transmembrane transport
X953_RS13720	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
X953_RS13725	COG1737	Transcriptional regulator
X953_RS13730	COG2971	BadF BadG BcrA BcrD
X953_RS13735	COG0716	FMN binding
X953_RS13750	COG1331	Highly conserved protein containing a thioredoxin domain
X953_RS13780	COG1971	Probably functions as a manganese efflux pump
X953_RS13795	COG2996	Protein conserved in bacteria
X953_RS13805	COG4895	conserved protein (DUF2196)
X953_RS13820	COG0561	phosphatase activity
X953_RS13840	COG4565	transcriptional regulatory protein
X953_RS13845	COG3290	protein histidine kinase activity
X953_RS13850	COG2271	Major facilitator Superfamily
X953_RS13855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X953_RS13870	COG1929	Belongs to the glycerate kinase type-1 family
X953_RS13875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
X953_RS13885	COG0747	negative chemotaxis
X953_RS13895	COG0601	transmembrane transport
X953_RS13900	COG4608	Belongs to the ABC transporter superfamily
X953_RS13910	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
X953_RS13920	COG0463	Glycosyl transferase, family 2
X953_RS13930	COG2076	Multidrug Resistance protein
X953_RS13935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
X953_RS13945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
X953_RS13955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_RS13960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X953_RS13965	COG0066	3-isopropylmalate dehydratase activity
X953_RS13970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
X953_RS13975	COG0473	3-isopropylmalate dehydrogenase activity
X953_RS13980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X953_RS13985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
X953_RS13990	COG0440	acetolactate synthase activity
X953_RS13995	COG0028	Belongs to the TPP enzyme family
X953_RS14000	COG0129	dihydroxy-acid dehydratase activity
X953_RS14005	COG0385	Bile acid
X953_RS14010	COG1574	metal-dependent hydrolase with the TIM-barrel fold
X953_RS14025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
X953_RS14035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X953_RS14040	COG1473	amidohydrolase
X953_RS14045	COG0251	oxidation-reduction process
X953_RS14050	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS14055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
X953_RS14060	COG1802	Transcriptional regulator
X953_RS14065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X953_RS14070	COG0006	proline dipeptidase activity
X953_RS14075	COG0656	L-ascorbic acid biosynthetic process
X953_RS14120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X953_RS14125	COG0805	protein transport
X953_RS14130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X953_RS14150	COG0583	DNA-binding transcription factor activity
X953_RS14155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
X953_RS14160	COG0686	Belongs to the AlaDH PNT family
X953_RS14165	COG2188	Transcriptional regulator
X953_RS14170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_RS14180	COG0765	amino acid transport
X953_RS14185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X953_RS14190	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS14195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
X953_RS14200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X953_RS14210	COG3258	Cytochrome c
X953_RS14215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
X953_RS14215	COG2010	Cytochrome c
X953_RS14220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X953_RS14245	COG0419	ATPase involved in DNA repair
X953_RS14250	COG0420	3'-5' exonuclease activity
X953_RS14265	COG0628	permease
X953_RS14270	COG1846	Transcriptional regulator
X953_RS14275	COG2814	Major facilitator Superfamily
X953_RS14290	COG0390	transport system, permease component
X953_RS14305	COG2706	6-phosphogluconolactonase activity
X953_RS14310	COG0516	GMP reductase activity
X953_RS14325	COG1105	Belongs to the carbohydrate kinase PfkB family
X953_RS14330	COG3684	Belongs to the aldolase LacD family
X953_RS14340	COG2222	sugar isomerase
X953_RS14345	COG2188	Transcriptional regulator
X953_RS14360	COG4166	transmembrane transport
X953_RS14370	COG1609	Transcriptional regulator
X953_RS14380	COG1316	TRANSCRIPTIONal
X953_RS14385	COG4166	transmembrane transport
X953_RS14390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
X953_RS14395	COG2233	PERMEase
X953_RS14405	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
X953_RS14440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
X953_RS14445	COG2223	nitrite transmembrane transporter activity
X953_RS14455	COG3764	Sortase (surface protein transpeptidase)
X953_RS14465	COG1268	BioY protein
X953_RS14475	COG3383	formate dehydrogenase (NAD+) activity
X953_RS14480	COG5609	conserved protein (DUF2294)
X953_RS14485	COG3223	Belongs to the PsiE family
X953_RS14490	COG0431	NADPH-dependent FMN reductase
X953_RS14505	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS14525	COG3541	Predicted nucleotidyltransferase
X953_RS14545	COG2814	Major facilitator Superfamily
X953_RS14555	COG4948	Mandelate Racemase Muconate Lactonizing
X953_RS14560	COG1404	Belongs to the peptidase S8 family
X953_RS14565	COG2027	D-alanyl-D-alanine carboxypeptidase
X953_RS14570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_RS14580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X953_RS14585	COG1556	Lactate utilization protein
X953_RS14590	COG1139	Iron-sulfur cluster binding protein
X953_RS14595	COG0247	lactate metabolic process
X953_RS14600	COG2186	Transcriptional regulator
X953_RS14605	COG1620	l-lactate permease
X953_RS14620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X953_RS14625	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
X953_RS14635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
X953_RS14645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
X953_RS14650	COG0657	acetylesterase activity
X953_RS14700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X953_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS14715	COG1215	transferase activity, transferring glycosyl groups
X953_RS14750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
X953_RS14755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
X953_RS14765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
X953_RS14770	COG0251	oxidation-reduction process
X953_RS14780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X953_RS14795	COG2368	4-hydroxyphenylacetate
X953_RS14800	COG1132	(ABC) transporter
X953_RS14810	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS14815	COG0840	transmembrane signaling receptor activity
X953_RS14825	COG1609	Transcriptional regulator
X953_RS14840	COG2233	PERMEase
X953_RS14845	COG0402	S-adenosylhomocysteine deaminase activity
X953_RS14855	COG3775	system Galactitol-specific IIC component
X953_RS14860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_RS14865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
X953_RS14870	COG2022	thiamine diphosphate biosynthetic process
X953_RS14880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_RS14885	COG0352	thiamine-phosphate diphosphorylase activity
X953_RS14915	COG1737	Transcriptional regulator
X953_RS14920	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
X953_RS14925	COG3876	Protein conserved in bacteria
X953_RS14930	COG1472	Belongs to the glycosyl hydrolase 3 family
X953_RS14935	COG0395	ABC-type sugar transport system, permease component
X953_RS14940	COG1175	transmembrane transport
X953_RS14950	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
X953_RS14955	COG1082	Xylose isomerase domain protein TIM barrel
X953_RS14960	COG0673	inositol 2-dehydrogenase activity
X953_RS14965	COG0673	inositol 2-dehydrogenase activity
X953_RS14975	COG0673	inositol 2-dehydrogenase activity
X953_RS14990	COG1653	transport
X953_RS14995	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS15000	COG1609	Transcriptional regulator
X953_RS15010	COG1454	alcohol dehydrogenase
X953_RS15015	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
X953_RS15015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
X953_RS15020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
X953_RS15025	COG2188	Transcriptional regulator
X953_RS15035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
X953_RS15040	COG2514	catechol 2,3-dioxygenase activity
X953_RS15045	COG1733	regulation of RNA biosynthetic process
X953_RS15055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
X953_RS15060	COG0583	DNA-binding transcription factor activity
X953_RS15065	COG0730	response to heat
X953_RS15070	COG0402	S-adenosylhomocysteine deaminase activity
X953_RS15105	COG1846	Transcriptional regulator
X953_RS15110	COG1033	growth of symbiont in host cell
X953_RS15110	COG2409	Drug exporters of the RND superfamily
X953_RS15120	COG4166	transmembrane transport
X953_RS15150	COG2936	dipeptidyl-peptidase activity
X953_RS15160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X953_RS15165	COG0601	transmembrane transport
X953_RS15175	COG4608	Belongs to the ABC transporter superfamily
X953_RS15180	COG0444	Belongs to the ABC transporter superfamily
X953_RS15185	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS15190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X953_RS15195	COG1757	Na H antiporter
X953_RS15205	COG3938	Belongs to the proline racemase family
X953_RS15210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_RS15235	COG2362	D-Aminopeptidase
X953_RS15245	COG4608	Belongs to the ABC transporter superfamily
X953_RS15250	COG0444	Belongs to the ABC transporter superfamily
X953_RS15255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X953_RS15260	COG0601	transmembrane transport
X953_RS15265	COG0747	negative chemotaxis
X953_RS15275	COG0366	Alpha amylase catalytic
X953_RS15285	COG1609	Transcriptional regulator
X953_RS15315	COG1011	Hydrolase
X953_RS15320	COG2936	dipeptidyl-peptidase activity
X953_RS15325	COG0174	glutamine synthetase
X953_RS15330	COG0493	'glutamate synthase
X953_RS15335	COG0067	glutamate synthase
X953_RS15335	COG0070	glutamate synthase
X953_RS15335	COG0069	glutamate synthase activity
X953_RS15340	COG0583	DNA-binding transcription factor activity
X953_RS15345	COG0367	asparagine synthase
X953_RS15350	COG0446	pyridine nucleotide-disulphide oxidoreductase
X953_RS15365	COG5444	nuclease activity
X953_RS15375	COG5444	nuclease activity
X953_RS15400	COG5298	Protein conserved in bacteria
X953_RS15405	COG1215	transferase activity, transferring glycosyl groups
X953_RS15420	COG1192	Involved in chromosome partitioning
X953_RS15430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X953_RS15440	COG3949	Membrane
X953_RS15445	COG4948	Mandelate Racemase Muconate Lactonizing
X953_RS15455	COG1473	amidohydrolase
X953_RS15465	COG1476	TRANSCRIPTIONal
X953_RS15470	COG2972	Histidine kinase
X953_RS15470	COG0745	RESPONSE REGULATOR receiver
X953_RS15595	COG4166	transmembrane transport
X953_RS15600	COG1737	Transcriptional regulator
X953_RS15605	COG1473	amidohydrolase
X953_RS15610	COG3716	PTS system mannose fructose sorbose family IID component
X953_RS15615	COG3715	PTS system
X953_RS15620	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_RS15620	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X953_RS15655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
X953_RS15710	COG0606	chelatase, subunit chli
X953_RS15770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X953_RS15775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
X953_RS15780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X953_RS15780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
X953_RS15785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
X953_RS15790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
X953_RS15805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
X953_RS15825	COG4464	protein tyrosine phosphatase activity
X953_RS15830	COG0489	protein tyrosine kinase activity
X953_RS15835	COG3944	biosynthesis protein
X953_RS15840	COG0791	NLP P60 protein
X953_RS15840	COG1388	LysM domain
X953_RS15875	COG0165	Argininosuccinate lyase
X953_RS15885	COG3842	ATPase activity
X953_RS15890	COG1840	ABC-type Fe3 transport system, periplasmic component
X953_RS15910	COG1940	carbohydrate kinase activity
X953_RS15925	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X953_RS15930	COG1482	cell wall glycoprotein biosynthetic process
X953_RS15935	COG1940	carbohydrate kinase activity
X953_RS15945	COG1175	transmembrane transport
X953_RS15955	COG2207	Transcriptional regulator
X953_RS15955	COG4753	response regulator
X953_RS15960	COG2972	Histidine kinase
X953_RS15965	COG1879	ABC-type sugar transport system periplasmic component
X953_RS15980	COG1175	transmembrane transport
X953_RS15985	COG1653	transport
X953_RS15995	COG2207	Transcriptional regulator
X953_RS15995	COG4753	response regulator
X953_RS16000	COG2972	Histidine kinase
X953_RS16015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
X953_RS16030	COG3142	Participates in the control of copper homeostasis
X953_RS16045	COG3711	transcriptional antiterminator
X953_RS16055	COG0432	Pfam Uncharacterised protein family UPF0047
X953_RS16060	COG0745	RESPONSE REGULATOR receiver
X953_RS16060	COG2972	Histidine kinase
X953_RS16070	COG3279	Response regulator of the LytR AlgR family
X953_RS16095	COG1316	TRANSCRIPTIONal
X953_RS16100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X953_RS16105	COG0438	transferase activity, transferring glycosyl groups
X953_RS16115	COG1216	Glycosyl transferase, family 2
X953_RS16135	COG0584	glycerophosphoryl diester phosphodiesterase
X953_RS16145	COG1682	transport, permease protein
X953_RS16185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
X953_RS16190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
X953_RS16200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
X953_RS16205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
X953_RS16210	COG1368	sulfuric ester hydrolase activity
X953_RS16225	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
X953_RS16230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X953_RS16235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X953_RS16245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X953_RS16270	COG2076	Multidrug Resistance protein
X953_RS16275	COG2076	Multidrug Resistance protein
X953_RS16295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
X953_RS16305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X953_RS16315	COG1309	transcriptional regulator
X953_RS16335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
X953_RS16345	COG4786	Flagellar basal body rod
X953_RS16350	COG4786	Flagellar basal body rod
X953_RS16355	COG1077	Cell shape determining protein MreB Mrl
X953_RS16360	COG1609	Transcriptional regulator
X953_RS16370	COG0739	heme binding
X953_RS16380	COG2385	sporulation resulting in formation of a cellular spore
X953_RS16385	COG4608	Belongs to the ABC transporter superfamily
X953_RS16390	COG0791	NLP P60 protein
X953_RS16395	COG4948	Mandelate Racemase Muconate Lactonizing
X953_RS16400	COG1619	proteins homologs of microcin C7 resistance protein MccF
X953_RS16405	COG4166	transmembrane transport
X953_RS16410	COG0444	Belongs to the ABC transporter superfamily
X953_RS16415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X953_RS16420	COG0601	transmembrane transport
X953_RS16425	COG2362	D-Aminopeptidase
X953_RS16430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
X953_RS16450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
X953_RS16455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
X953_RS16460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
X953_RS16465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
X953_RS16470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
X953_RS16475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
X953_RS16480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
X953_RS16485	COG0356	it plays a direct role in the translocation of protons across the membrane
X953_RS16495	COG1404	Belongs to the peptidase S8 family
X953_RS16500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
X953_RS16505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
X953_RS16510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
X953_RS16515	COG4475	Protein of unknown function (DUF436)
X953_RS16520	COG0698	ribose 5-phosphate isomerase
X953_RS16525	COG0840	transmembrane signaling receptor activity
X953_RS16530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
X953_RS16535	COG1971	Probably functions as a manganese efflux pump
X953_RS16540	COG0009	L-threonylcarbamoyladenylate synthase
X953_RS16555	COG2890	protein-(glutamine-N5) methyltransferase activity
X953_RS16560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
X953_RS16565	COG1435	thymidine kinase activity
X953_RS16575	COG0254	rRNA binding
X953_RS16580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
X953_RS16585	COG1494	fructose-1,6-bisphosphatase
X953_RS16590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
X953_RS16595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
X953_RS16600	COG0191	fructose-bisphosphate aldolase activity
X953_RS16610	COG0504	CTP synthase activity
X953_RS16615	COG3343	RNA polymerase activity
X953_RS16625	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
X953_RS16625	COG1703	isobutyryl-CoA mutase activity
X953_RS16625	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
X953_RS16635	COG1703	isobutyryl-CoA mutase activity
X953_RS16640	COG1960	acyl-CoA dehydrogenase activity
X953_RS16645	COG1960	acyl-CoA dehydrogenase activity
X953_RS16650	COG1250	3-hydroxyacyl-CoA dehydrogenase
X953_RS16655	COG0183	Belongs to the thiolase family
X953_RS16660	COG2181	nitrate reductase activity
X953_RS16660	COG0247	lactate metabolic process
X953_RS16665	COG0018	arginyl-trna synthetase
X953_RS16675	COG0010	Belongs to the arginase family
X953_RS16680	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
X953_RS16685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X953_RS16695	COG3465	dGTPase activity
X953_RS16700	COG1078	dGTPase activity
X953_RS16705	COG0095	Lipoate-protein ligase
X953_RS16710	COG0280	phosphate acetyltransferase
X953_RS16715	COG3253	May function as heme-dependent peroxidase
X953_RS16730	COG2363	Small membrane protein
X953_RS16745	COG0069	glutamate synthase activity
X953_RS16760	COG3314	Sporulation integral membrane protein YlbJ
X953_RS16775	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
X953_RS16780	COG1793	dna ligase
X953_RS16780	COG3285	dna ligase
X953_RS16790	COG1764	response to oxidative stress
X953_RS16800	COG3189	MarR family transcriptional regulator
X953_RS16805	COG0861	Integral membrane protein TerC family
X953_RS16810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
X953_RS16815	COG0628	permease
X953_RS16835	COG1114	Component of the transport system for branched-chain amino acids
X953_RS16840	COG0514	ATP-dependent DNA helicase (RecQ)
X953_RS16850	COG1115	amino acid carrier protein
X953_RS16855	COG1607	acyl-coa hydrolase
X953_RS16860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X953_RS16865	COG0626	cystathionine gamma-synthase activity
X953_RS16870	COG2962	Rard protein
X953_RS16875	COG2873	o-acetylhomoserine
X953_RS16880	COG2755	lipolytic protein G-D-S-L family
X953_RS16885	COG4698	Protein conserved in bacteria
X953_RS16905	COG0488	(ABC) transporter
X953_RS16910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X953_RS16915	COG0156	8-amino-7-oxononanoate synthase activity
X953_RS16920	COG1388	LysM domain
X953_RS16920	COG1388	LysM domain
X953_RS16920	COG3584	3D domain protein
X953_RS16920	COG3584	3D domain protein
X953_RS16925	COG4086	secreted protein
X953_RS16930	COG2814	Major facilitator Superfamily
X953_RS16940	COG1979	alcohol dehydrogenase
X953_RS16945	COG0251	oxidation-reduction process
X953_RS16950	COG0741	lytic transglycosylase activity
X953_RS16960	COG0534	Mate efflux family protein
X953_RS16975	COG2358	TRAP transporter, solute receptor (TAXI family
X953_RS16980	COG0318	PFAM AMP-dependent synthetase and ligase
X953_RS16985	COG4608	Belongs to the ABC transporter superfamily
X953_RS16990	COG0444	Belongs to the ABC transporter superfamily
X953_RS16995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X953_RS17000	COG0601	transmembrane transport
X953_RS17005	COG4166	transmembrane transport
X953_RS17015	COG2070	2-Nitropropane dioxygenase
X953_RS17020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
X953_RS17025	COG2814	Major facilitator Superfamily
X953_RS17030	COG1737	Transcriptional regulator
X953_RS17035	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
X953_RS17040	COG2610	gluconate transmembrane transporter activity
X953_RS17045	COG1070	Carbohydrate kinase
X953_RS17055	COG1288	antiporter activity
X953_RS17060	COG2032	superoxide dismutase activity
X953_RS17070	COG1725	Transcriptional regulator
X953_RS17075	COG4152	abc transporter atp-binding protein
X953_RS17090	COG0655	NAD(P)H dehydrogenase (quinone) activity
X953_RS17095	COG4991	sh3 domain protein
X953_RS17095	COG0860	N-Acetylmuramoyl-L-alanine amidase
X953_RS17095	COG3103	Sh3 type 3 domain protein
X953_RS17105	COG2226	methyltransferase
X953_RS17125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X953_RS17140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X953_RS17150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X953_RS17155	COG0583	DNA-binding transcription factor activity
X953_RS17160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
X953_RS17165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
X953_RS17190	COG3246	L-lysine catabolic process to acetate
X953_RS17200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_RS17205	COG2323	membrane
X953_RS17210	COG0367	asparagine synthase
X953_RS17215	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
X953_RS17230	COG1115	amino acid carrier protein
X953_RS17235	COG0753	catalase activity
X953_RS17240	COG2199	diguanylate cyclase activity
X953_RS17250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
X953_RS17255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X953_RS17260	COG0655	NAD(P)H dehydrogenase (quinone) activity
X953_RS17265	COG0501	Belongs to the peptidase M48B family
X953_RS17270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X953_RS17275	COG2197	response regulator
X953_RS17280	COG4585	Histidine kinase
X953_RS17285	COG3239	Fatty acid desaturase
X953_RS17300	COG1199	ATP-dependent helicase activity
X953_RS17310	COG3279	Response regulator of the LytR AlgR family
X953_RS17320	COG1252	NADH dehydrogenase
X953_RS17325	COG1346	cytolysis
X953_RS17330	COG1380	Effector of murein hydrolase LrgA
X953_RS17335	COG0165	Argininosuccinate lyase
X953_RS17340	COG0137	argininosuccinate synthase activity
X953_RS17345	COG2076	Multidrug Resistance protein
X953_RS17355	COG1309	transcriptional regulator
X953_RS17360	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS17365	COG1846	Transcriptional regulator
X953_RS17375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
X953_RS17380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
X953_RS17385	COG0573	inorganic phosphate transmembrane transporter activity
X953_RS17390	COG0581	inorganic phosphate transmembrane transporter activity
X953_RS17395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
X953_RS17415	COG2323	membrane
X953_RS17430	COG2814	Major facilitator Superfamily
X953_RS17435	COG2404	hydrolase activity, acting on ester bonds
X953_RS17450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X953_RS17465	COG1621	beta-fructofuranosidase activity
X953_RS17470	COG2190	(PTS) system
X953_RS17475	COG3871	stress protein (general stress protein 26)
X953_RS17480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X953_RS17490	COG1609	Transcriptional regulator
X953_RS17495	COG0709	Synthesizes selenophosphate from selenide and ATP
X953_RS17500	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
X953_RS17510	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
X953_RS17535	COG1607	acyl-coa hydrolase
X953_RS17555	COG0583	DNA-binding transcription factor activity
X953_RS17560	COG0725	ABC transporter, periplasmic molybdate-binding protein
X953_RS17565	COG4149	molybdate abc transporter
X953_RS17570	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
X953_RS17585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X953_RS17595	COG3711	transcriptional antiterminator
X953_RS17600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X953_RS17600	COG1263	PTS System
X953_RS17600	COG2190	(PTS) system
X953_RS17605	COG1393	Belongs to the ArsC family
X953_RS17625	COG1999	signal sequence binding
X953_RS17630	COG1349	DNA-binding transcription factor activity
X953_RS17645	COG0785	Cytochrome C biogenesis protein
X953_RS17650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X953_RS17655	COG0745	RESPONSE REGULATOR receiver
X953_RS17660	COG2205	protein histidine kinase activity
X953_RS17670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_RS17675	COG0730	response to heat
X953_RS17680	COG0425	Belongs to the sulfur carrier protein TusA family
X953_RS17685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_RS17685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_RS17690	COG2210	Belongs to the sulfur carrier protein TusA family
X953_RS17695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_RS17695	COG0425	Belongs to the sulfur carrier protein TusA family
X953_RS17700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_RS17705	COG2210	Belongs to the sulfur carrier protein TusA family
X953_RS17710	COG1937	Protein conserved in bacteria
X953_RS17720	COG4536	flavin adenine dinucleotide binding
X953_RS17735	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
X953_RS17745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X953_RS17745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X953_RS17750	COG0456	acetyltransferase
X953_RS17765	COG2719	SpoVR family
X953_RS17775	COG2718	Belongs to the UPF0229 family
X953_RS17780	COG1960	acyl-CoA dehydrogenase activity
X953_RS17785	COG1024	Enoyl-CoA hydratase
X953_RS17790	COG1250	3-hydroxyacyl-CoA dehydrogenase
X953_RS17795	COG0318	PFAM AMP-dependent synthetase and ligase
X953_RS17805	COG2045	Belongs to the ComB family
X953_RS17820	COG1309	transcriptional regulator
X953_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS17835	COG2766	serine protein kinase
X953_RS17855	COG0270	DNA (cytosine-5-)-methyltransferase activity
X953_RS17990	COG0740	serine-type endopeptidase activity
X953_RS18085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X953_RS18090	COG2766	serine protein kinase
X953_RS18120	COG0492	ferredoxin-NADP+ reductase activity
X953_RS18125	COG1120	ATPase activity
X953_RS18130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X953_RS18135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X953_RS18140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X953_RS18165	COG1301	dicarboxylic acid transport
X953_RS18170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X953_RS18185	COG2814	Major facilitator Superfamily
X953_RS18190	COG0517	IMP dehydrogenase activity
X953_RS18190	COG0516	GMP reductase activity
X953_RS18195	COG1846	Transcriptional regulator
X953_RS18205	COG1349	DNA-binding transcription factor activity
X953_RS18210	COG1105	Belongs to the carbohydrate kinase PfkB family
X953_RS18215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X953_RS18215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X953_RS18215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_RS18230	COG1827	regulation of RNA biosynthetic process
X953_RS18235	COG0157	Belongs to the NadC ModD family
X953_RS18255	COG1366	Belongs to the anti-sigma-factor antagonist family
X953_RS18265	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS18275	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
X953_RS18280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X953_RS18305	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
X953_RS18310	COG4943	cyclic-guanylate-specific phosphodiesterase activity
X953_RS18320	COG0666	response to abiotic stimulus
X953_RS18325	COG2807	transmembrane transport
X953_RS18330	COG0702	epimerase
X953_RS18335	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS18340	COG1510	regulation of RNA biosynthetic process
X953_RS18350	COG1012	belongs to the aldehyde dehydrogenase family
X953_RS18385	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
X953_RS18415	COG2003	Belongs to the UPF0758 family
X953_RS18440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X953_RS18450	COG3711	transcriptional antiterminator
X953_RS18450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
X953_RS18455	COG1486	melibiose metabolic process
X953_RS18465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
X953_RS18470	COG3394	polysaccharide catabolic process
X953_RS18475	COG1447	Phosphotransferase system cellobiose-specific component IIA
X953_RS18480	COG3876	Protein conserved in bacteria
X953_RS18485	COG1733	regulation of RNA biosynthetic process
X953_RS18500	COG3639	organic phosphonate transmembrane transporter activity
X953_RS18510	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
X953_RS18520	COG0737	Belongs to the 5'-nucleotidase family
X953_RS18530	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS18540	COG3773	Cell wall hydrolase
X953_RS18555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
X953_RS18620	COG1028	Short-chain dehydrogenase reductase Sdr
X953_RS18630	COG1132	(ABC) transporter
X953_RS18640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X953_RS18645	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
X953_RS18650	COG4853	Protein conserved in bacteria
X953_RS18655	COG4863	YycH protein
X953_RS18660	COG5002	protein histidine kinase activity
X953_RS18665	COG0745	RESPONSE REGULATOR receiver
X953_RS18670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
X953_RS18675	COG0305	Participates in initiation and elongation during chromosome replication
X953_RS18680	COG0359	binds to the 23S rRNA
X953_RS18685	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
X953_RS18690	COG4241	membrane
X953_RS18700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
X953_RS18705	COG0629	single-stranded DNA binding
X953_RS18710	COG0360	Binds together with S18 to 16S ribosomal RNA
X953_RS18715	COG0012	GTP binding
X953_RS18720	COG4481	Protein conserved in bacteria
X953_RS18725	COG0668	transmembrane transport
X953_RS18730	COG3949	Membrane
X953_RS18750	COG1475	DNA binding
X953_RS18755	COG1192	Involved in chromosome partitioning
X953_RS18760	COG1475	DNA binding
X953_RS18765	COG0357	Ribosomal RNA small subunit methyltransferase G
X953_RS18770	COG0445	tRNA wobble uridine modification
X953_RS18775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
X953_RS18785	COG1847	R3H domain protein
X953_RS18790	COG0706	membrane insertase activity
X953_RS18795	COG0594	ribonuclease P activity
X953_RS18800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
X953_RS18820	COG0592	DNA-directed DNA polymerase activity
X953_RS18850	COG0187	DNA topoisomerase II activity
X953_RS18865	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
X953_RS18890	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
X953_RS18915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
X953_RS19035	COG2885	chlorophyll binding
X953_RS19035	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
X953_RS19040	COG1525	nuclease
X953_RS19100	COG1388	LysM domain
X953_RS19125	COG0142	geranyltranstransferase activity
X953_RS19155	COG2720	vancomycin resistance protein
X953_RS19170	COG2200	EAL domain
X953_RS19180	COG0860	N-Acetylmuramoyl-L-alanine amidase
X953_RS19185	COG1404	Belongs to the peptidase S8 family
X953_RS19190	COG2197	response regulator
X953_RS19205	COG1396	sequence-specific DNA binding
X953_RS19235	COG4193	domain, Protein
X953_RS19245	COG4980	gas vesicle protein
X953_RS19250	COG0791	NLP P60 protein
X953_RS19250	COG1388	LysM domain
X953_RS19280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids