locus-tag	class	description
LCH97_RS00005	COG0416	fatty acid biosynthetic process
LCH97_RS00010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LCH97_RS00025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LCH97_RS00030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LCH97_RS00035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LCH97_RS00045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LCH97_RS00060	COG0287	Prephenate dehydrogenase
LCH97_RS00080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LCH97_RS00085	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LCH97_RS00095	COG0776	regulation of translation
LCH97_RS00105	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LCH97_RS00110	COG0284	orotidine-5'-phosphate decarboxylase activity
LCH97_RS00115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LCH97_RS00125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LCH97_RS00135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LCH97_RS00145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCH97_RS00150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LCH97_RS00150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LCH97_RS00155	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LCH97_RS00165	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LCH97_RS00170	COG3706	GGDEF domain
LCH97_RS00190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCH97_RS00200	COG1794	racemase activity, acting on amino acids and derivatives
LCH97_RS00210	COG0446	pyridine nucleotide-disulphide oxidoreductase
LCH97_RS00215	COG0840	transmembrane signaling receptor activity
LCH97_RS00220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LCH97_RS00235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LCH97_RS00245	COG1937	Protein conserved in bacteria
LCH97_RS00255	COG0360	Binds together with S18 to 16S ribosomal RNA
LCH97_RS00260	COG2965	DNA replication, synthesis of RNA primer
LCH97_RS00265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LCH97_RS00270	COG0359	binds to the 23S rRNA
LCH97_RS00290	COG0456	acetyltransferase
LCH97_RS00290	COG0454	-acetyltransferase
LCH97_RS00300	COG1335	isochorismatase
LCH97_RS00310	COG0494	nUDIX hydrolase
LCH97_RS00330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LCH97_RS00335	COG0628	permease
LCH97_RS00340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LCH97_RS00345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LCH97_RS00355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LCH97_RS00355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LCH97_RS00360	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LCH97_RS00365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LCH97_RS00385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LCH97_RS00390	COG3161	chorismate lyase activity
LCH97_RS00400	COG1346	cytolysis
LCH97_RS00450	COG1012	belongs to the aldehyde dehydrogenase family
LCH97_RS00460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH97_RS00470	COG3385	transposase activity
LCH97_RS00480	COG2814	Major facilitator Superfamily
LCH97_RS00520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCH97_RS00530	COG2974	May be involved in recombination
LCH97_RS00545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LCH97_RS00555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCH97_RS00625	COG0386	Belongs to the glutathione peroxidase family
LCH97_RS00630	COG0717	Belongs to the dCTP deaminase family
LCH97_RS00635	COG2193	ferroxidase activity
LCH97_RS00650	COG1653	transport
LCH97_RS00665	COG0366	Alpha amylase catalytic
LCH97_RS00670	COG3842	ATPase activity
LCH97_RS00685	COG1970	mechanosensitive ion channel activity
LCH97_RS00690	COG1620	l-lactate permease
LCH97_RS00695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LCH97_RS00700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LCH97_RS00725	COG0395	ABC-type sugar transport system, permease component
LCH97_RS00730	COG3842	ATPase activity
LCH97_RS00735	COG1686	Belongs to the peptidase S11 family
LCH97_RS00740	COG0556	nucleotide-excision repair
LCH97_RS00745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LCH97_RS00750	COG2201	protein-glutamate methylesterase activity
LCH97_RS00760	COG1677	Flagellar hook-basal body complex protein FliE
LCH97_RS00765	COG1766	The M ring may be actively involved in energy transduction
LCH97_RS00770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LCH97_RS00780	COG1157	protein secretion by the type III secretion system
LCH97_RS00805	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LCH97_RS00830	COG0217	transcriptional regulatory protein
LCH97_RS00840	COG2066	Belongs to the glutaminase family
LCH97_RS00845	COG1418	mRNA catabolic process
LCH97_RS00850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LCH97_RS00860	COG5001	Diguanylate cyclase
LCH97_RS00865	COG0277	FAD linked oxidase domain protein
LCH97_RS00870	COG4178	(ABC) transporter
LCH97_RS00875	COG0215	cysteine-tRNA ligase activity
LCH97_RS00880	COG0254	rRNA binding
LCH97_RS00895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LCH97_RS00925	COG1024	Enoyl-CoA hydratase
LCH97_RS00930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LCH97_RS00935	COG1960	acyl-CoA dehydrogenase activity
LCH97_RS00940	COG0789	Transcriptional regulator
LCH97_RS00945	COG0318	PFAM AMP-dependent synthetase and ligase
LCH97_RS00950	COG3012	SEC-C Motif Domain Protein
LCH97_RS00950	COG3318	Belongs to the UPF0149 family
LCH97_RS00965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LCH97_RS00970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LCH97_RS00980	COG1960	acyl-CoA dehydrogenase activity
LCH97_RS01000	COG2766	serine protein kinase
LCH97_RS01010	COG2719	SpoVR family
LCH97_RS01015	COG5002	protein histidine kinase activity
LCH97_RS01015	COG2198	Histidine kinase
LCH97_RS01015	COG0784	Response regulator, receiver
LCH97_RS01030	COG3321	synthase
LCH97_RS01030	COG0604	alcohol dehydrogenase
LCH97_RS01070	COG0831	urea catabolic process
LCH97_RS01075	COG0832	Belongs to the urease beta subunit family
LCH97_RS01080	COG0804	urea catabolic process
LCH97_RS01085	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LCH97_RS01090	COG0830	nickel cation binding
LCH97_RS01095	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LCH97_RS01115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LCH97_RS01120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LCH97_RS01130	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LCH97_RS01135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LCH97_RS01140	COG0167	dihydroorotate dehydrogenase activity
LCH97_RS01150	COG1360	Flagellar Motor Protein
LCH97_RS01165	COG0546	phosphoglycolate phosphatase activity
LCH97_RS01175	COG1530	ribonuclease E activity
LCH97_RS01210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LCH97_RS01215	COG2137	regulation of response to DNA damage stimulus
LCH97_RS01220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LCH97_RS01225	COG1420	regulation of RNA biosynthetic process
LCH97_RS01230	COG2951	lytic endotransglycosylase activity
LCH97_RS01240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LCH97_RS01245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LCH97_RS01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LCH97_RS01255	COG1393	Belongs to the ArsC family
LCH97_RS01265	COG0318	PFAM AMP-dependent synthetase and ligase
LCH97_RS01270	COG0779	Required for maturation of 30S ribosomal subunits
LCH97_RS01275	COG2251	uridine kinase activity
LCH97_RS01275	COG0195	Participates in both transcription termination and antitermination
LCH97_RS01280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LCH97_RS01285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LCH97_RS01290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LCH97_RS01295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LCH97_RS01300	COG1185	polyribonucleotide nucleotidyltransferase activity
LCH97_RS01305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LCH97_RS01315	COG0318	PFAM AMP-dependent synthetase and ligase
LCH97_RS01320	COG0784	Response regulator, receiver
LCH97_RS01320	COG4191	Histidine kinase
LCH97_RS01330	COG0673	inositol 2-dehydrogenase activity
LCH97_RS01335	COG0745	RESPONSE REGULATOR receiver
LCH97_RS01340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LCH97_RS01355	COG1012	belongs to the aldehyde dehydrogenase family
LCH97_RS01360	COG3724	N-succinylarginine dihydrolase activity
LCH97_RS01365	COG0559	Belongs to the binding-protein-dependent transport system permease family
LCH97_RS01385	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LCH97_RS01400	COG0513	Belongs to the DEAD box helicase family
LCH97_RS01410	COG1024	Enoyl-CoA hydratase
LCH97_RS01415	COG1024	Enoyl-CoA hydratase
LCH97_RS01430	COG1250	3-hydroxyacyl-CoA dehydrogenase
LCH97_RS01450	COG0183	Belongs to the thiolase family
LCH97_RS01455	COG1960	acyl-CoA dehydrogenase activity
LCH97_RS01470	COG1469	GTP cyclohydrolase I activity
LCH97_RS01475	COG3174	membrane
LCH97_RS01480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LCH97_RS01485	COG0142	geranyltranstransferase activity
LCH97_RS01490	COG1722	exodeoxyribonuclease VII activity
LCH97_RS01495	COG0861	Integral membrane protein TerC family
LCH97_RS01500	COG0300	oxidoreductase activity
LCH97_RS01510	COG0525	valine-tRNA ligase activity
LCH97_RS01520	COG3706	GGDEF domain
LCH97_RS01535	COG1562	ergosterol biosynthetic process
LCH97_RS01545	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LCH97_RS01550	COG1028	Short-chain dehydrogenase reductase Sdr
LCH97_RS01585	COG2814	Major facilitator Superfamily
LCH97_RS01590	COG1566	PFAM secretion protein HlyD family protein
LCH97_RS01595	COG1538	Outer membrane efflux protein
LCH97_RS01615	COG0791	NLP P60 protein
LCH97_RS01630	COG1136	(ABC) transporter
LCH97_RS01635	COG3264	Mechanosensitive ion channel
LCH97_RS01635	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LCH97_RS01640	COG4566	intracellular signal transduction
LCH97_RS01645	COG0494	nUDIX hydrolase
LCH97_RS01655	COG2205	protein histidine kinase activity
LCH97_RS01655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCH97_RS01670	COG3568	Endonuclease Exonuclease Phosphatase
LCH97_RS01680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCH97_RS01685	COG1136	(ABC) transporter
LCH97_RS01685	COG0577	efflux transmembrane transporter activity
LCH97_RS01710	COG1477	protein flavinylation
LCH97_RS01715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LCH97_RS01720	COG4774	siderophore transport
LCH97_RS01740	COG2011	ABC-type metal ion transport system permease component
LCH97_RS01775	COG0653	protein targeting
LCH97_RS01800	COG0006	proline dipeptidase activity
LCH97_RS01805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LCH97_RS01810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LCH97_RS01850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LCH97_RS01860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCH97_RS01875	COG0730	response to heat
LCH97_RS01895	COG0861	Integral membrane protein TerC family
LCH97_RS01905	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LCH97_RS01920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LCH97_RS01925	COG0583	DNA-binding transcription factor activity
LCH97_RS01935	COG0598	Magnesium transport protein CorA
LCH97_RS01940	COG1132	(ABC) transporter
LCH97_RS01950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LCH97_RS01990	COG1760	l-serine dehydratase
LCH97_RS01995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LCH97_RS02005	COG2910	NAD(P)H-binding
LCH97_RS02010	COG0583	DNA-binding transcription factor activity
LCH97_RS02020	COG2040	homocysteine
LCH97_RS02035	COG0513	Belongs to the DEAD box helicase family
LCH97_RS02060	COG2818	Glycosylase
LCH97_RS02070	COG3707	response regulator
LCH97_RS02075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LCH97_RS02080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LCH97_RS02085	COG1116	anion transmembrane transporter activity
LCH97_RS02090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCH97_RS02095	COG2146	nitrite reductase [NAD(P)H] activity
LCH97_RS02100	COG0243	molybdopterin cofactor binding
LCH97_RS02115	COG1448	Aminotransferase
LCH97_RS02120	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LCH97_RS02135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH97_RS02140	COG3938	Belongs to the proline racemase family
LCH97_RS02145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LCH97_RS02150	COG1012	belongs to the aldehyde dehydrogenase family
LCH97_RS02155	COG1802	Transcriptional regulator
LCH97_RS02160	COG3706	GGDEF domain
LCH97_RS02175	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
LCH97_RS02180	COG2833	Protein of unknown function (DUF455)
LCH97_RS02195	COG0826	peptidase U32
LCH97_RS02205	COG0018	arginyl-trna synthetase
LCH97_RS02225	COG0183	Belongs to the thiolase family
LCH97_RS02230	COG3243	poly(R)-hydroxyalkanoic acid synthase
LCH97_RS02240	COG0179	Fumarylacetoacetate (FAA) hydrolase
LCH97_RS02245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LCH97_RS02265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LCH97_RS02275	COG0066	3-isopropylmalate dehydratase activity
LCH97_RS02280	COG0473	3-isopropylmalate dehydrogenase activity
LCH97_RS02290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LCH97_RS02315	COG0101	tRNA pseudouridine synthase activity
LCH97_RS02320	COG0135	phosphoribosylanthranilate isomerase activity
LCH97_RS02325	COG0133	tryptophan synthase activity
LCH97_RS02330	COG2329	Antibiotic biosynthesis monooxygenase
LCH97_RS02335	COG0159	tryptophan synthase activity
LCH97_RS02340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LCH97_RS02355	COG2988	succinylglutamate desuccinylase activity
LCH97_RS02360	COG1024	Enoyl-CoA hydratase
LCH97_RS02365	COG2267	carboxylic ester hydrolase activity
LCH97_RS02370	COG5001	Diguanylate cyclase
LCH97_RS02370	COG2203	Gaf domain
LCH97_RS02370	COG3706	GGDEF domain
LCH97_RS02370	COG4251	negative regulation of phosphorylation
LCH97_RS02375	COG3842	ATPase activity
LCH97_RS02380	COG1176	ABC-type spermidine putrescine transport system, permease component I
LCH97_RS02385	COG1177	transmembrane transport
LCH97_RS02390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH97_RS02395	COG1166	arginine decarboxylase activity
LCH97_RS02410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LCH97_RS02475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCH97_RS02480	COG2807	transmembrane transport
LCH97_RS02485	COG1846	Transcriptional regulator
LCH97_RS02490	COG1136	(ABC) transporter
LCH97_RS02495	COG0577	efflux transmembrane transporter activity
LCH97_RS02510	COG3275	phosphorelay sensor kinase activity
LCH97_RS02520	COG3713	MltA-interacting MipA family protein
LCH97_RS02530	COG0405	Gamma-glutamyltransferase
LCH97_RS02535	COG0747	negative chemotaxis
LCH97_RS02550	COG0523	cobalamin synthesis protein
LCH97_RS02600	COG1764	response to oxidative stress
LCH97_RS02605	COG1846	Transcriptional regulator
LCH97_RS02620	COG2207	Transcriptional regulator
LCH97_RS02640	COG0477	Major facilitator Superfamily
LCH97_RS02645	COG1028	Short-chain dehydrogenase reductase Sdr
LCH97_RS02650	COG0583	DNA-binding transcription factor activity
LCH97_RS02660	COG0583	DNA-binding transcription factor activity
LCH97_RS02665	COG1929	Belongs to the glycerate kinase type-1 family
LCH97_RS02705	COG2814	Major facilitator Superfamily
LCH97_RS02710	COG4533	DNA binding
LCH97_RS02725	COG2828	Protein conserved in bacteria
LCH97_RS02765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LCH97_RS02775	COG0481	GTPase activity
LCH97_RS02790	COG0571	ribonuclease III activity
LCH97_RS02795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LCH97_RS02800	COG2329	Antibiotic biosynthesis monooxygenase
LCH97_RS02805	COG1381	Involved in DNA repair and RecF pathway recombination
LCH97_RS02810	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LCH97_RS02815	COG0736	holo-[acyl-carrier-protein] synthase activity
LCH97_RS02820	COG1472	Belongs to the glycosyl hydrolase 3 family
LCH97_RS02875	COG4974	Belongs to the 'phage' integrase family
LCH97_RS02885	COG1956	GAF domain-containing protein
LCH97_RS02890	COG1028	Short-chain dehydrogenase reductase Sdr
LCH97_RS02900	COG2154	pterin-4-alpha-carbinolamine dehydratase
LCH97_RS02905	COG0501	Belongs to the peptidase M48B family
LCH97_RS02910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LCH97_RS02915	COG0166	Belongs to the GPI family
LCH97_RS02925	COG1744	ABC transporter substrate-binding protein PnrA-like
LCH97_RS02930	COG3845	ABC transporter
LCH97_RS02935	COG4603	Belongs to the binding-protein-dependent transport system permease family
LCH97_RS02940	COG1079	Belongs to the binding-protein-dependent transport system permease family
LCH97_RS02945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LCH97_RS02950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LCH97_RS02985	COG0733	neurotransmitter:sodium symporter activity
LCH97_RS03000	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LCH97_RS03020	COG0791	NLP P60 protein
LCH97_RS03025	COG0488	(ABC) transporter
LCH97_RS03040	COG0285	dihydrofolate synthase activity
LCH97_RS03055	COG1286	toxin biosynthetic process
LCH97_RS03075	COG1960	acyl-CoA dehydrogenase activity
LCH97_RS03080	COG1607	acyl-coa hydrolase
LCH97_RS03090	COG1250	3-hydroxyacyl-CoA dehydrogenase
LCH97_RS03090	COG1024	Enoyl-CoA hydratase
LCH97_RS03095	COG0183	Belongs to the thiolase family
LCH97_RS03105	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LCH97_RS03115	COG0134	indole-3-glycerol-phosphate synthase activity
LCH97_RS03120	COG0429	hydrolase of the alpha beta-hydrolase fold
LCH97_RS03125	COG0521	Mo-molybdopterin cofactor biosynthetic process
LCH97_RS03130	COG3028	Belongs to the UPF0307 family
LCH97_RS03135	COG0312	modulator of DNA gyrase
LCH97_RS03140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LCH97_RS03150	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LCH97_RS03235	COG0825	malonyl-CoA metabolic process
LCH97_RS03240	COG0037	tRNA processing
LCH97_RS03245	COG0295	cytidine deaminase activity
LCH97_RS03320	COG0667	Aldo Keto reductase
LCH97_RS03325	COG0702	epimerase
LCH97_RS03330	COG0446	pyridine nucleotide-disulphide oxidoreductase
LCH97_RS03330	COG1902	pentaerythritol trinitrate reductase activity
LCH97_RS03335	COG4221	oxidoreductase activity
LCH97_RS03340	COG0604	alcohol dehydrogenase
LCH97_RS03345	COG2267	carboxylic ester hydrolase activity
LCH97_RS03390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LCH97_RS03395	COG2011	ABC-type metal ion transport system permease component
LCH97_RS03405	COG0512	Glutamine amidotransferase of anthranilate synthase
LCH97_RS03410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LCH97_RS03425	COG0024	Methionine aminopeptidase
LCH97_RS03440	COG1199	ATP-dependent helicase activity
LCH97_RS03450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LCH97_RS03455	COG0137	argininosuccinate synthase activity
LCH97_RS03470	COG1666	GTP binding
LCH97_RS03475	COG0625	glutathione transferase activity
LCH97_RS03485	COG2200	EAL domain
LCH97_RS03490	COG1741	Belongs to the pirin family
LCH97_RS03495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LCH97_RS03505	COG0840	transmembrane signaling receptor activity
LCH97_RS03510	COG0840	transmembrane signaling receptor activity
LCH97_RS03545	COG1047	Peptidyl-prolyl cis-trans
LCH97_RS03590	COG1522	sequence-specific DNA binding
LCH97_RS03600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LCH97_RS03640	COG0347	Belongs to the P(II) protein family
LCH97_RS03645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LCH97_RS03645	COG0047	phosphoribosylformylglycinamidine synthase activity
LCH97_RS03740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LCH97_RS03750	COG0739	heme binding
LCH97_RS03755	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LCH97_RS03760	COG1674	ftsk spoiiie
LCH97_RS03765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LCH97_RS03780	COG0688	phosphatidylethanolamine metabolic process
LCH97_RS03790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LCH97_RS03815	COG0419	ATPase involved in DNA repair
LCH97_RS03820	COG0420	3'-5' exonuclease activity
LCH97_RS03825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LCH97_RS03840	COG0123	including yeast histone deacetylase and acetoin utilization protein
LCH97_RS03845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LCH97_RS03850	COG4191	Histidine kinase
LCH97_RS03855	COG4566	intracellular signal transduction
LCH97_RS03860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LCH97_RS03865	COG0497	DNA recombination
LCH97_RS03875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LCH97_RS03880	COG0174	glutamine synthetase
LCH97_RS03895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LCH97_RS03910	COG3411	Ferredoxin
LCH97_RS03920	COG2081	HI0933 family
LCH97_RS03925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LCH97_RS03930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCH97_RS03940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LCH97_RS03945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LCH97_RS03950	COG0740	serine-type endopeptidase activity
LCH97_RS03955	COG0544	peptidyl-prolyl cis-trans isomerase activity
LCH97_RS03960	COG0315	cyclic pyranopterin monophosphate synthase activity
LCH97_RS03965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LCH97_RS03970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LCH97_RS03970	COG1199	ATP-dependent helicase activity
LCH97_RS04005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LCH97_RS04010	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LCH97_RS04015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LCH97_RS04020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LCH97_RS04025	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LCH97_RS04045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LCH97_RS04050	COG0575	Belongs to the CDS family
LCH97_RS04055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LCH97_RS04060	COG0233	cytoplasmic translational termination
LCH97_RS04065	COG0528	UMP kinase activity
LCH97_RS04070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LCH97_RS04075	COG0052	Belongs to the universal ribosomal protein uS2 family
LCH97_RS04095	COG2816	NAD+ diphosphatase activity
LCH97_RS04125	COG2831	hemolysin activation secretion protein
LCH97_RS04130	COG2195	Cleaves the N-terminal amino acid of tripeptides
LCH97_RS04145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH97_RS04150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LCH97_RS04155	COG0321	lipoyl(octanoyl) transferase activity
LCH97_RS04160	COG2921	Belongs to the UPF0250 family
LCH97_RS04165	COG1686	Belongs to the peptidase S11 family
LCH97_RS04170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LCH97_RS04175	COG0546	phosphoglycolate phosphatase activity
LCH97_RS04190	COG1217	gtp-binding protein TYPA
LCH97_RS04205	COG0582	viral genome integration into host DNA
LCH97_RS04265	COG2974	May be involved in recombination
LCH97_RS04310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LCH97_RS04345	COG2944	sequence-specific DNA binding
LCH97_RS04555	COG0582	viral genome integration into host DNA
LCH97_RS04610	COG0469	pyruvate kinase activity
LCH97_RS04620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LCH97_RS04635	COG2217	Heavy metal translocating P-type atpase
LCH97_RS04650	COG0569	domain protein
LCH97_RS04655	COG0346	lactoylglutathione lyase activity
LCH97_RS04665	COG1196	nuclear chromosome segregation
LCH97_RS04665	COG0739	heme binding
LCH97_RS04665	COG0741	lytic transglycosylase activity
LCH97_RS04670	COG0702	epimerase
LCH97_RS04675	COG0617	tRNA 3'-terminal CCA addition
LCH97_RS04680	COG2828	Protein conserved in bacteria
LCH97_RS04695	COG2096	Adenosyltransferase
LCH97_RS04710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LCH97_RS04715	COG0795	lipopolysaccharide-transporting ATPase activity
LCH97_RS04725	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LCH97_RS04730	COG0840	transmembrane signaling receptor activity
LCH97_RS04740	COG0516	GMP reductase activity
LCH97_RS04750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LCH97_RS04760	COG2917	probably involved in intracellular septation
LCH97_RS04765	COG2350	Protein conserved in bacteria
LCH97_RS04770	COG0271	Belongs to the BolA IbaG family
LCH97_RS04775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCH97_RS04780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCH97_RS04785	COG1024	Enoyl-CoA hydratase
LCH97_RS04795	COG0803	Belongs to the bacterial solute-binding protein 9 family
LCH97_RS04815	COG0523	cobalamin synthesis protein
LCH97_RS04820	COG0735	belongs to the Fur family
LCH97_RS04870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LCH97_RS04880	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LCH97_RS04885	COG0312	modulator of DNA gyrase
LCH97_RS04890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LCH97_RS04900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LCH97_RS04915	COG0859	PFAM glycosyl transferase family 9
LCH97_RS04920	COG1309	transcriptional regulator
LCH97_RS04940	COG0492	ferredoxin-NADP+ reductase activity
LCH97_RS04945	COG2840	Smr protein MutS2
LCH97_RS04950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LCH97_RS04955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LCH97_RS04965	COG2354	Protein conserved in bacteria
LCH97_RS04970	COG0443	Heat shock 70 kDa protein
LCH97_RS04985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LCH97_RS04990	COG3123	guanosine phosphorylase activity
LCH97_RS04995	COG3437	response regulator, receiver
LCH97_RS04995	COG2770	Histidine kinase
LCH97_RS05000	COG1278	Cold shock
LCH97_RS05020	COG4191	Histidine kinase
LCH97_RS05025	COG2204	response regulator
LCH97_RS05030	COG0243	molybdopterin cofactor binding
LCH97_RS05030	COG3383	formate dehydrogenase (NAD+) activity
LCH97_RS05035	COG0437	4 iron, 4 sulfur cluster binding
LCH97_RS05040	COG2864	formate dehydrogenase
LCH97_RS05045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LCH97_RS05060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LCH97_RS05075	COG1360	Flagellar Motor Protein
LCH97_RS05085	COG0174	glutamine synthetase
LCH97_RS05090	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LCH97_RS05095	COG0686	Belongs to the AlaDH PNT family
LCH97_RS05100	COG1396	sequence-specific DNA binding
LCH97_RS05100	COG1917	Cupin 2, conserved barrel domain protein
LCH97_RS05105	COG1012	belongs to the aldehyde dehydrogenase family
LCH97_RS05115	COG0746	molybdenum cofactor guanylyltransferase activity
LCH97_RS05120	COG0564	pseudouridine synthase activity
LCH97_RS05165	COG0314	molybdopterin synthase activity
LCH97_RS05175	COG1763	Mo-molybdopterin cofactor biosynthetic process
LCH97_RS05180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LCH97_RS05185	COG1024	Enoyl-CoA hydratase
LCH97_RS05200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LCH97_RS05220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LCH97_RS05245	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LCH97_RS05265	COG0765	amino acid transport
LCH97_RS05285	COG5265	(ABC) transporter
LCH97_RS05290	COG2967	ApaG domain
LCH97_RS05295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LCH97_RS05300	COG1028	Short-chain dehydrogenase reductase Sdr
LCH97_RS05310	COG0546	phosphoglycolate phosphatase activity
LCH97_RS05345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCH97_RS05350	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LCH97_RS05360	COG1797	cobyrinic acid a,c-diamide synthase activity
LCH97_RS05365	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LCH97_RS05375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCH97_RS05380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCH97_RS05385	COG1492	cobalamin metabolic process
LCH97_RS05410	COG2199	diguanylate cyclase activity
LCH97_RS05440	COG1049	propionate catabolic process, 2-methylcitrate cycle
LCH97_RS05445	COG0583	DNA-binding transcription factor activity
LCH97_RS05460	COG2084	Dehydrogenase
LCH97_RS05465	COG3622	Belongs to the hyi family
LCH97_RS05470	COG0513	Belongs to the DEAD box helicase family
LCH97_RS05475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LCH97_RS05485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LCH97_RS05490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LCH97_RS05500	COG0307	riboflavin synthase, alpha
LCH97_RS05505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LCH97_RS05520	COG1609	Transcriptional regulator
LCH97_RS05525	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCH97_RS05525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LCH97_RS05530	COG1105	Belongs to the carbohydrate kinase PfkB family
LCH97_RS05535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LCH97_RS05535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LCH97_RS05550	COG3300	MHYT domain
LCH97_RS05550	COG5001	Diguanylate cyclase
LCH97_RS05575	COG0727	PFAM Uncharacterised protein family (UPF0153)
LCH97_RS05610	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LCH97_RS05630	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LCH97_RS05635	COG3634	alkyl hydroperoxide reductase activity
LCH97_RS05655	COG0542	response to heat
LCH97_RS05665	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LCH97_RS05665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH97_RS05675	COG1435	thymidine kinase activity
LCH97_RS05690	COG3209	COG3209 Rhs family protein
LCH97_RS05700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LCH97_RS05715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LCH97_RS05715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LCH97_RS05720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LCH97_RS05725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LCH97_RS05730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LCH97_RS05745	COG1643	Atp-dependent helicase
LCH97_RS05750	COG0784	Response regulator, receiver
LCH97_RS05750	COG3437	response regulator, receiver
LCH97_RS05755	COG3437	response regulator, receiver
LCH97_RS05760	COG1187	pseudouridine synthase activity
LCH97_RS05765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LCH97_RS05780	COG1706	bacterial-type flagellum-dependent cell motility
LCH97_RS05785	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LCH97_RS05795	COG4787	bacterial-type flagellum-dependent cell motility
LCH97_RS05810	COG1558	bacterial-type flagellum-dependent cell motility
LCH97_RS05820	COG1765	OsmC-like protein
LCH97_RS05825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LCH97_RS05830	COG0488	(ABC) transporter
LCH97_RS05840	COG1349	DNA-binding transcription factor activity
LCH97_RS05845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LCH97_RS05860	COG2866	Carboxypeptidase
LCH97_RS05890	COG0583	DNA-binding transcription factor activity
LCH97_RS05895	COG3162	membrane
LCH97_RS05900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LCH97_RS05905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LCH97_RS05910	COG4657	Part of a membrane complex involved in electron transport
LCH97_RS05915	COG2878	Part of a membrane complex involved in electron transport
LCH97_RS05930	COG4659	FMN binding
LCH97_RS05935	COG4660	Part of a membrane complex involved in electron transport
LCH97_RS05940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LCH97_RS05945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LCH97_RS05950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LCH97_RS05960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LCH97_RS05965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LCH97_RS05970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LCH97_RS05980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LCH97_RS05985	COG0617	tRNA 3'-terminal CCA addition
LCH97_RS05995	COG0534	Mate efflux family protein
LCH97_RS06000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LCH97_RS06025	COG2860	membrane
LCH97_RS06030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LCH97_RS06035	COG3118	belongs to the thioredoxin family
LCH97_RS06075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LCH97_RS06100	COG0280	phosphate acetyltransferase
LCH97_RS06100	COG0281	malic enzyme
LCH97_RS06140	COG0659	secondary active sulfate transmembrane transporter activity
LCH97_RS06150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LCH97_RS06155	COG0737	Belongs to the 5'-nucleotidase family
LCH97_RS06165	COG0840	transmembrane signaling receptor activity
LCH97_RS06175	COG2234	aminopeptidase activity
LCH97_RS06200	COG0697	spore germination
LCH97_RS06235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LCH97_RS06250	COG0745	RESPONSE REGULATOR receiver
LCH97_RS06260	COG2205	protein histidine kinase activity
LCH97_RS06270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LCH97_RS06275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH97_RS06290	COG0004	ammonium transporteR
LCH97_RS06300	COG4771	TonB-dependent receptor
LCH97_RS06305	COG3720	iron ion transport
LCH97_RS06315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCH97_RS06325	COG0024	Methionine aminopeptidase
LCH97_RS06340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LCH97_RS06350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LCH97_RS06355	COG3842	ATPase activity
LCH97_RS06360	COG1178	ABC-type Fe3 transport system permease component
LCH97_RS06380	COG0500	methyltransferase
LCH97_RS06395	COG1840	ABC-type Fe3 transport system, periplasmic component
LCH97_RS06405	COG3842	ATPase activity
LCH97_RS06410	COG1178	ABC-type Fe3 transport system permease component
LCH97_RS06425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH97_RS06465	COG0745	RESPONSE REGULATOR receiver
LCH97_RS06470	COG0642	Histidine kinase
LCH97_RS06475	COG0023	Translation Initiation Factor
LCH97_RS06480	COG0657	acetylesterase activity
LCH97_RS06485	COG0583	DNA-binding transcription factor activity
LCH97_RS06490	COG1902	pentaerythritol trinitrate reductase activity
LCH97_RS06575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LCH97_RS06590	COG1959	2 iron, 2 sulfur cluster binding
LCH97_RS06635	COG0322	excinuclease ABC activity
LCH97_RS06655	COG2267	carboxylic ester hydrolase activity
LCH97_RS06660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LCH97_RS06670	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LCH97_RS06680	COG0121	glutamine amidotransferase
LCH97_RS06705	COG2003	Belongs to the UPF0758 family
LCH97_RS06710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LCH97_RS06715	COG0756	dUTP diphosphatase activity
LCH97_RS06720	COG3706	GGDEF domain
LCH97_RS06730	COG1176	ABC-type spermidine putrescine transport system, permease component I
LCH97_RS06740	COG3842	ATPase activity
LCH97_RS06745	COG2902	Dehydrogenase
LCH97_RS06750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCH97_RS06755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCH97_RS06760	COG4215	(ABC) transporter
LCH97_RS06785	COG1846	Transcriptional regulator
LCH97_RS06790	COG3038	cytochrome b561
LCH97_RS06795	COG2353	YceI-like domain
LCH97_RS06800	COG2353	YceI-like domain
LCH97_RS06845	COG1773	rubredoxin
LCH97_RS06875	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LCH97_RS06885	COG0409	Hydrogenase expression formation protein
LCH97_RS06890	COG0309	Hydrogenase expression formation protein (HypE)
LCH97_RS06895	COG2204	response regulator
LCH97_RS06930	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LCH97_RS06940	COG3093	addiction module antidote protein HigA
LCH97_RS06955	COG1376	ErfK ybiS ycfS ynhG family protein
LCH97_RS06960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LCH97_RS07000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LCH97_RS07160	COG2369	cell adhesion
LCH97_RS07170	COG4373	Mu-like prophage FluMu protein gp28
LCH97_RS07200	COG3023	N-Acetylmuramoyl-L-alanine amidase
LCH97_RS07220	COG0129	dihydroxy-acid dehydratase activity
LCH97_RS07225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LCH97_RS07235	COG1522	sequence-specific DNA binding
LCH97_RS07245	COG0583	DNA-binding transcription factor activity
LCH97_RS07250	COG2855	membrane
LCH97_RS07260	COG2217	Heavy metal translocating P-type atpase
LCH97_RS07265	COG0598	Magnesium transport protein CorA
LCH97_RS07270	COG0248	Ppx GppA phosphatase
LCH97_RS07275	COG0704	Plays a role in the regulation of phosphate uptake
LCH97_RS07280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LCH97_RS07285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LCH97_RS07290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LCH97_RS07300	COG0328	RNA-DNA hybrid ribonuclease activity
LCH97_RS07305	COG2226	methyltransferase
LCH97_RS07310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCH97_RS07315	COG0741	lytic transglycosylase activity
LCH97_RS07315	COG1388	LysM domain
LCH97_RS07320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LCH97_RS07325	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LCH97_RS07330	COG0330	HflC and HflK could
LCH97_RS07335	COG0330	HflC and HflK could
LCH97_RS07340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LCH97_RS07345	COG1923	regulation of RNA biosynthetic process
LCH97_RS07350	COG1160	GTP binding
LCH97_RS07355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LCH97_RS07365	COG0124	histidyl-tRNA synthetase
LCH97_RS07370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LCH97_RS07385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LCH97_RS07390	COG0105	UTP biosynthetic process
LCH97_RS07400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LCH97_RS07415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LCH97_RS07425	COG2925	Exonuclease
LCH97_RS07430	COG0730	response to heat
LCH97_RS07435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LCH97_RS07440	COG1846	Transcriptional regulator
LCH97_RS07450	COG1566	PFAM secretion protein HlyD family protein
LCH97_RS07455	COG2814	Major facilitator Superfamily
LCH97_RS07460	COG0251	oxidation-reduction process
LCH97_RS07480	COG2906	2 iron, 2 sulfur cluster binding
LCH97_RS07495	COG0482	sulfurtransferase activity
LCH97_RS07515	COG2814	Major facilitator Superfamily
LCH97_RS07520	COG0583	DNA-binding transcription factor activity
LCH97_RS07525	COG1454	alcohol dehydrogenase
LCH97_RS07530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LCH97_RS07535	COG0840	transmembrane signaling receptor activity
LCH97_RS07545	COG0174	glutamine synthetase
LCH97_RS07560	COG3850	Histidine kinase
LCH97_RS07600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LCH97_RS07605	COG2119	membrane
LCH97_RS07615	COG0557	exoribonuclease II activity
LCH97_RS07645	COG1490	D-aminoacyl-tRNA deacylase activity
LCH97_RS07650	COG3022	response to hydroperoxide
LCH97_RS07655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LCH97_RS07670	COG0444	Belongs to the ABC transporter superfamily
LCH97_RS07680	COG0601	transmembrane transport
LCH97_RS07685	COG0747	negative chemotaxis
LCH97_RS07695	COG1045	serine acetyltransferase
LCH97_RS07700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LCH97_RS07705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LCH97_RS07720	COG4521	taurine ABC transporter
LCH97_RS07725	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LCH97_RS07730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LCH97_RS07735	COG2175	clavaminate synthase activity
LCH97_RS07740	COG3040	lipid binding
LCH97_RS07750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LCH97_RS07755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LCH97_RS07760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LCH97_RS07765	COG3265	gluconokinase activity
LCH97_RS07770	COG1609	Transcriptional regulator
LCH97_RS07785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCH97_RS07785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCH97_RS07795	COG0489	protein tyrosine kinase activity
LCH97_RS07800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LCH97_RS07825	COG1253	flavin adenine dinucleotide binding
LCH97_RS07830	COG0840	transmembrane signaling receptor activity
LCH97_RS07835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LCH97_RS07835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LCH97_RS07840	COG0509	glycine decarboxylation via glycine cleavage system
LCH97_RS07845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LCH97_RS07855	COG0531	amino acid
LCH97_RS07860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LCH97_RS07870	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LCH97_RS07875	COG2201	protein-glutamate methylesterase activity
LCH97_RS07900	COG0643	Histidine kinase
LCH97_RS07900	COG2198	Histidine kinase
LCH97_RS07905	COG0745	RESPONSE REGULATOR receiver
LCH97_RS07920	COG0784	Response regulator, receiver
LCH97_RS07920	COG0835	chemotaxis
LCH97_RS07925	COG0784	Response regulator, receiver
LCH97_RS07925	COG0835	chemotaxis
LCH97_RS07930	COG0745	RESPONSE REGULATOR receiver
LCH97_RS07935	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LCH97_RS07940	COG2198	Histidine kinase
LCH97_RS07940	COG0784	Response regulator, receiver
LCH97_RS07940	COG0643	Histidine kinase
LCH97_RS07945	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LCH97_RS07950	COG1214	PFAM Peptidase M22, glycoprotease
LCH97_RS07955	COG0456	acetyltransferase
LCH97_RS07960	COG1573	uracil-dna glycosylase
LCH97_RS07980	COG1739	Uncharacterized protein family UPF0029
LCH97_RS07985	COG4566	intracellular signal transduction
LCH97_RS08000	COG1802	Transcriptional regulator
LCH97_RS08025	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LCH97_RS08030	COG0788	formyltetrahydrofolate deformylase activity
LCH97_RS08060	COG0840	transmembrane signaling receptor activity
LCH97_RS08080	COG0625	glutathione transferase activity
LCH97_RS08090	COG0583	DNA-binding transcription factor activity
LCH97_RS08105	COG0776	regulation of translation
LCH97_RS08110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCH97_RS08110	COG0072	phenylalanine-tRNA ligase activity
LCH97_RS08115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LCH97_RS08120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LCH97_RS08125	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LCH97_RS08135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LCH97_RS08145	COG0343	queuine tRNA-ribosyltransferase activity
LCH97_RS08150	COG1862	Preprotein translocase
LCH97_RS08155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LCH97_RS08160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LCH97_RS08165	COG0586	Pfam SNARE associated Golgi protein
LCH97_RS08170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LCH97_RS08180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LCH97_RS08185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LCH97_RS08190	COG0504	CTP synthase activity
LCH97_RS08195	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LCH97_RS08200	COG0148	phosphopyruvate hydratase activity
LCH97_RS08205	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LCH97_RS08215	COG2914	Belongs to the UPF0125 (RnfH) family
LCH97_RS08220	COG2867	negative regulation of translational initiation
LCH97_RS08225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LCH97_RS08235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LCH97_RS08235	COG0519	Catalyzes the synthesis of GMP from XMP
LCH97_RS08250	COG3186	Phenylalanine-4-hydroxylase
LCH97_RS08260	COG0697	spore germination
LCH97_RS08265	COG0308	aminopeptidase N
LCH97_RS08275	COG3278	Belongs to the heme-copper respiratory oxidase family
LCH97_RS08295	COG0348	domain, Protein
LCH97_RS08330	COG3033	Beta-eliminating lyase
LCH97_RS08340	COG0564	pseudouridine synthase activity
LCH97_RS08350	COG1607	acyl-coa hydrolase
LCH97_RS08355	COG1132	(ABC) transporter
LCH97_RS08375	COG0789	Transcriptional regulator
LCH97_RS08380	COG0583	DNA-binding transcription factor activity
LCH97_RS08395	COG0045	succinate-CoA ligase (ADP-forming) activity
LCH97_RS08400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LCH97_RS08405	COG0508	dehydrogenase complex catalyzes the overall conversion of
LCH97_RS08410	COG0567	Dehydrogenase, E1 component
LCH97_RS08420	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LCH97_RS08425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LCH97_RS08430	COG1053	succinate dehydrogenase
LCH97_RS08440	COG2009	succinate dehydrogenase
LCH97_RS08445	COG2188	Transcriptional regulator
LCH97_RS08450	COG0039	L-malate dehydrogenase activity
LCH97_RS08460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LCH97_RS08515	COG0402	S-adenosylhomocysteine deaminase activity
LCH97_RS08520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LCH97_RS08550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LCH97_RS08560	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LCH97_RS08580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LCH97_RS08585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LCH97_RS08585	COG1199	ATP-dependent helicase activity
LCH97_RS08595	COG0583	DNA-binding transcription factor activity
LCH97_RS08610	COG0326	Molecular chaperone. Has ATPase activity
LCH97_RS08615	COG4191	Histidine kinase
LCH97_RS08615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCH97_RS08620	COG3437	response regulator, receiver
LCH97_RS08620	COG0784	Response regulator, receiver
LCH97_RS08625	COG0563	adenylate kinase activity
LCH97_RS08630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LCH97_RS08635	COG2835	tetraacyldisaccharide 4'-kinase activity
LCH97_RS08640	COG1663	tetraacyldisaccharide 4'-kinase activity
LCH97_RS08645	COG0848	biopolymer transport protein
LCH97_RS08650	COG0811	peptide transport
LCH97_RS08655	COG1570	exodeoxyribonuclease VII activity
LCH97_RS08665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LCH97_RS08670	COG4942	peptidase
LCH97_RS08675	COG0793	Belongs to the peptidase S41A family
LCH97_RS08690	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LCH97_RS08715	COG0564	pseudouridine synthase activity
LCH97_RS08720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LCH97_RS08730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LCH97_RS08740	COG0205	6-phosphofructokinase activity
LCH97_RS08750	COG3647	Membrane
LCH97_RS08755	COG0494	nUDIX hydrolase
LCH97_RS08765	COG0174	glutamine synthetase
LCH97_RS08775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCH97_RS08805	COG1741	Belongs to the pirin family
LCH97_RS08820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LCH97_RS08825	COG1063	alcohol dehydrogenase
LCH97_RS08830	COG0156	8-amino-7-oxononanoate synthase activity
LCH97_RS08850	COG1115	amino acid carrier protein
LCH97_RS08855	COG0484	heat shock protein binding
LCH97_RS08860	COG0443	Heat shock 70 kDa protein
LCH97_RS08865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LCH97_RS08875	COG2224	Isocitrate lyase
LCH97_RS08880	COG0531	amino acid
LCH97_RS08885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LCH97_RS08900	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LCH97_RS08910	COG0625	glutathione transferase activity
LCH97_RS08925	COG1279	arginine transmembrane transporter activity
LCH97_RS08945	COG1234	tRNA 3'-trailer cleavage
LCH97_RS08950	COG0084	hydrolase, TatD family'
LCH97_RS08965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LCH97_RS08970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LCH97_RS08980	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LCH97_RS08985	COG4181	ATPase activity
LCH97_RS08995	COG2814	Major facilitator Superfamily
LCH97_RS09000	COG0450	alkyl hydroperoxide reductase
LCH97_RS09005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LCH97_RS09020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LCH97_RS09040	COG0268	Binds directly to 16S ribosomal RNA
LCH97_RS09045	COG0728	peptidoglycan biosynthetic process
LCH97_RS09050	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LCH97_RS09050	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LCH97_RS09055	COG0488	(ABC) transporter
LCH97_RS09070	COG3384	dioxygenase
LCH97_RS09095	COG4172	Belongs to the ABC transporter superfamily
LCH97_RS09100	COG0583	DNA-binding transcription factor activity
LCH97_RS09110	COG3706	GGDEF domain
LCH97_RS09120	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LCH97_RS09125	COG1032	radical SAM domain protein
LCH97_RS09160	COG0527	aspartate kinase activity
LCH97_RS09165	COG0745	RESPONSE REGULATOR receiver
LCH97_RS09170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LCH97_RS09185	COG0247	lactate metabolic process
LCH97_RS09190	COG1139	Iron-sulfur cluster binding protein
LCH97_RS09200	COG0513	Belongs to the DEAD box helicase family
LCH97_RS09205	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LCH97_RS09245	COG0436	Aminotransferase
LCH97_RS09265	COG1252	NADH dehydrogenase
LCH97_RS09270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LCH97_RS09285	COG3047	cAMP biosynthetic process
LCH97_RS09285	COG2885	chlorophyll binding
LCH97_RS09295	COG2226	methyltransferase
LCH97_RS09305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LCH97_RS09310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LCH97_RS09315	COG0511	ligase activity, forming carbon-carbon bonds
LCH97_RS09320	COG0439	Biotin carboxylase
LCH97_RS09325	COG2264	protein methyltransferase activity
LCH97_RS09340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LCH97_RS09350	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LCH97_RS09365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LCH97_RS09370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LCH97_RS09375	COG0668	transmembrane transport
LCH97_RS09395	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LCH97_RS09405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCH97_RS09415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LCH97_RS09420	COG4608	Belongs to the ABC transporter superfamily
LCH97_RS09425	COG0444	Belongs to the ABC transporter superfamily
LCH97_RS09430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCH97_RS09435	COG0601	transmembrane transport
LCH97_RS09440	COG0747	negative chemotaxis
LCH97_RS09460	COG1104	cysteine desulfurase activity
LCH97_RS09465	COG0822	iron-sulfur transferase activity
LCH97_RS09475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LCH97_RS09480	COG0443	Heat shock 70 kDa protein
LCH97_RS09485	COG0633	Ferredoxin
LCH97_RS09490	COG2975	iron-sulfur cluster assembly
LCH97_RS09495	COG0572	uridine kinase
LCH97_RS09510	COG1115	amino acid carrier protein
LCH97_RS09515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LCH97_RS09525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LCH97_RS09530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LCH97_RS09535	COG1534	Rna-binding protein
LCH97_RS09625	COG1960	acyl-CoA dehydrogenase activity
LCH97_RS09640	COG2030	dehydratase
LCH97_RS09655	COG0802	atpase or kinase
LCH97_RS09660	COG0860	N-Acetylmuramoyl-L-alanine amidase
LCH97_RS09665	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LCH97_RS09670	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LCH97_RS09675	COG0237	dephospho-CoA kinase activity
LCH97_RS09680	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LCH97_RS09700	COG0415	Belongs to the DNA photolyase family
LCH97_RS09710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LCH97_RS09715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LCH97_RS09735	COG1968	undecaprenyl-diphosphatase activity
LCH97_RS09755	COG2960	long-chain fatty acid transporting porin activity
LCH97_RS09765	COG0004	ammonium transporteR
LCH97_RS09770	COG2969	positive regulation of protein catabolic process
LCH97_RS09775	COG0625	glutathione transferase activity
LCH97_RS09780	COG2857	Cytochrome c1
LCH97_RS09785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LCH97_RS09790	COG0723	plastoquinol--plastocyanin reductase activity
LCH97_RS09795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LCH97_RS09800	COG0459	protein refolding
LCH97_RS09810	COG0493	'glutamate synthase
LCH97_RS09815	COG0067	glutamate synthase
LCH97_RS09815	COG0069	glutamate synthase activity
LCH97_RS09815	COG0070	glutamate synthase
LCH97_RS09820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCH97_RS09855	COG0765	amino acid transport
LCH97_RS09890	COG0840	transmembrane signaling receptor activity
LCH97_RS09900	COG0840	transmembrane signaling receptor activity
LCH97_RS09905	COG0745	RESPONSE REGULATOR receiver
LCH97_RS09910	COG2205	protein histidine kinase activity
LCH97_RS09920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LCH97_RS09930	COG3266	domain, Protein
LCH97_RS09930	COG0515	serine threonine protein kinase
LCH97_RS09935	COG1561	YicC-like family, N-terminal region
LCH97_RS09940	COG2084	Dehydrogenase
LCH97_RS09945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LCH97_RS09970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LCH97_RS09990	COG0438	transferase activity, transferring glycosyl groups
LCH97_RS09990	COG1216	Glycosyl transferase, family 2
LCH97_RS10000	COG0022	dehydrogenase e1 component
LCH97_RS10005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LCH97_RS10020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LCH97_RS10030	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LCH97_RS10035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LCH97_RS10040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LCH97_RS10050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LCH97_RS10070	COG1678	Uncharacterized ACR, COG1678
LCH97_RS10075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LCH97_RS10090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LCH97_RS10095	COG3530	Putative quorum-sensing-regulated virulence factor
LCH97_RS10140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LCH97_RS10160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LCH97_RS10165	COG1309	transcriptional regulator
LCH97_RS10180	COG1538	Outer membrane efflux protein
LCH97_RS10185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LCH97_RS10195	COG5002	protein histidine kinase activity
LCH97_RS10195	COG3447	MASE1 domain protein
LCH97_RS10195	COG5001	Diguanylate cyclase
LCH97_RS10205	COG0456	acetyltransferase
LCH97_RS10245	COG1324	tolerance protein
LCH97_RS10250	COG3030	protein affecting phage T7 exclusion by the F plasmid
LCH97_RS10255	COG1872	DUF167
LCH97_RS10260	COG0783	Belongs to the Dps family
LCH97_RS10275	COG0824	Thioesterase
LCH97_RS10280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCH97_RS10285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LCH97_RS10290	COG2204	response regulator
LCH97_RS10295	COG5000	phosphorelay sensor kinase activity
LCH97_RS10305	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LCH97_RS10305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LCH97_RS10310	COG0501	Belongs to the peptidase M48B family
LCH97_RS10315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LCH97_RS10320	COG0242	peptide deformylase activity
LCH97_RS10330	COG0758	DNA mediated transformation
LCH97_RS10335	COG2922	Belongs to the Smg family
LCH97_RS10360	COG0189	ligase activity
LCH97_RS10375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCH97_RS10390	COG0446	pyridine nucleotide-disulphide oxidoreductase
LCH97_RS10390	COG1902	pentaerythritol trinitrate reductase activity
LCH97_RS10395	COG0288	reversible hydration of carbon dioxide
LCH97_RS10415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCH97_RS10420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LCH97_RS10425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LCH97_RS10430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LCH97_RS10440	COG2885	chlorophyll binding
LCH97_RS10445	COG0823	Involved in the tonB-independent uptake of proteins
LCH97_RS10485	COG0210	DNA helicase
LCH97_RS10495	COG1879	ABC-type sugar transport system periplasmic component
LCH97_RS10500	COG1172	Belongs to the binding-protein-dependent transport system permease family
LCH97_RS10505	COG1129	ABC transporter
LCH97_RS10510	COG1869	D-ribose catabolic process
LCH97_RS10515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LCH97_RS10520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LCH97_RS10520	COG2755	lipolytic protein G-D-S-L family
LCH97_RS10530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LCH97_RS10530	COG4651	solute:proton antiporter activity
LCH97_RS10535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LCH97_RS10545	COG1702	phosphate starvation-inducible protein PhoH
LCH97_RS10550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LCH97_RS10555	COG4535	Mg2 and Co2 transporter CorC
LCH97_RS10560	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LCH97_RS10570	COG0840	transmembrane signaling receptor activity
LCH97_RS10580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LCH97_RS10585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCH97_RS10590	COG0203	ribosomal protein L17
LCH97_RS10595	COG0202	RNA polymerase activity
LCH97_RS10600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LCH97_RS10605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LCH97_RS10610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LCH97_RS10615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LCH97_RS10620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LCH97_RS10625	COG0201	protein transport
LCH97_RS10630	COG0200	Binds to the 23S rRNA
LCH97_RS10635	COG1841	ribosomal large subunit assembly
LCH97_RS10645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LCH97_RS10650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LCH97_RS10655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LCH97_RS10660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LCH97_RS10665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LCH97_RS10670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LCH97_RS10675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LCH97_RS10680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LCH97_RS10685	COG0255	Belongs to the universal ribosomal protein uL29 family
LCH97_RS10690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LCH97_RS10695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LCH97_RS10700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LCH97_RS10705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LCH97_RS10710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LCH97_RS10715	COG0089	rRNA binding
LCH97_RS10720	COG0088	Forms part of the polypeptide exit tunnel
LCH97_RS10725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LCH97_RS10730	COG0051	transcription antitermination factor activity, RNA binding
LCH97_RS10735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LCH97_RS10740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LCH97_RS10745	COG0049	tRNA binding
LCH97_RS10750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LCH97_RS10755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LCH97_RS10760	COG0085	RNA polymerase activity
LCH97_RS10770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LCH97_RS10785	COG0081	regulation of translation
LCH97_RS10790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LCH97_RS10810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LCH97_RS10830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LCH97_RS10835	COG0742	ribosomal rna small subunit methyltransferase
LCH97_RS10845	COG2884	Cell division ATP-binding protein ftsE
LCH97_RS10900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LCH97_RS10905	COG3046	protein related to deoxyribodipyrimidine photolyase
LCH97_RS10915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LCH97_RS10915	COG0519	Catalyzes the synthesis of GMP from XMP
LCH97_RS10920	COG2255	four-way junction helicase activity
LCH97_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
LCH97_RS10935	COG0632	four-way junction helicase activity
LCH97_RS10950	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LCH97_RS10965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LCH97_RS10970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCH97_RS10975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LCH97_RS10990	COG2199	diguanylate cyclase activity
LCH97_RS10990	COG2200	EAL domain
LCH97_RS10990	COG2203	Gaf domain
LCH97_RS10995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LCH97_RS11020	COG0477	Major facilitator Superfamily
LCH97_RS11035	COG4266	Belongs to the allantoicase family
LCH97_RS11040	COG1126	abc transporter atp-binding protein
LCH97_RS11045	COG0765	amino acid transport
LCH97_RS11050	COG0765	amino acid transport
LCH97_RS11060	COG2186	Transcriptional regulator
LCH97_RS11065	COG1187	pseudouridine synthase activity
LCH97_RS11075	COG3132	Protein of unknown function, DUF480
LCH97_RS11080	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LCH97_RS11095	COG0174	glutamine synthetase
LCH97_RS11105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LCH97_RS11110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LCH97_RS11180	COG0653	protein targeting
LCH97_RS11185	COG4608	Belongs to the ABC transporter superfamily
LCH97_RS11195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCH97_RS11200	COG0601	transmembrane transport
LCH97_RS11205	COG4166	transmembrane transport
LCH97_RS11210	COG0418	dihydroorotase activity
LCH97_RS11230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LCH97_RS11250	COG1181	Belongs to the D-alanine--D-alanine ligase family
LCH97_RS11255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LCH97_RS11260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LCH97_RS11265	COG0772	Belongs to the SEDS family
LCH97_RS11270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LCH97_RS11275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LCH97_RS11280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LCH97_RS11285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LCH97_RS11300	COG0275	rRNA processing
LCH97_RS11305	COG2001	Belongs to the MraZ family
LCH97_RS11310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LCH97_RS11315	COG0154	amidase activity
LCH97_RS11320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LCH97_RS11325	COG1077	Cell shape determining protein MreB Mrl
LCH97_RS11330	COG1792	Involved in formation and maintenance of cell shape
LCH97_RS11340	COG0768	penicillin binding
LCH97_RS11345	COG0772	Belongs to the SEDS family
LCH97_RS11375	COG2169	Transcriptional regulator
LCH97_RS11375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LCH97_RS11390	COG0584	glycerophosphoryl diester phosphodiesterase
LCH97_RS11395	COG5001	Diguanylate cyclase
LCH97_RS11395	COG3300	MHYT domain
LCH97_RS11405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LCH97_RS11415	COG2205	protein histidine kinase activity
LCH97_RS11420	COG0745	RESPONSE REGULATOR receiver
LCH97_RS11425	COG1752	Esterase of the alpha-beta hydrolase superfamily
LCH97_RS11430	COG1752	Esterase of the alpha-beta hydrolase superfamily
LCH97_RS11435	COG2226	methyltransferase
LCH97_RS11440	COG2267	carboxylic ester hydrolase activity
LCH97_RS11450	COG0156	8-amino-7-oxononanoate synthase activity
LCH97_RS11455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LCH97_RS11465	COG1040	competence protein
LCH97_RS11470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LCH97_RS11485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LCH97_RS11490	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LCH97_RS11500	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LCH97_RS11510	COG0259	pyridoxamine-phosphate oxidase activity
LCH97_RS11525	COG4807	Protein conserved in bacteria
LCH97_RS11535	COG2207	Transcriptional regulator
LCH97_RS11540	COG1881	PFAM PEBP family protein
LCH97_RS11550	COG2827	Endonuclease containing a URI domain
LCH97_RS11560	COG3706	GGDEF domain
LCH97_RS11565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCH97_RS11590	COG0557	exoribonuclease II activity
LCH97_RS11605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LCH97_RS11615	COG0436	Aminotransferase
LCH97_RS11620	COG0659	secondary active sulfate transmembrane transporter activity
LCH97_RS11625	COG1113	amino acid transport
LCH97_RS11630	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LCH97_RS11635	COG4989	oxidoreductase activity
LCH97_RS11640	COG3842	ATPase activity
LCH97_RS11645	COG0395	ABC-type sugar transport system, permease component
LCH97_RS11650	COG1175	transmembrane transport
LCH97_RS11680	COG1091	dTDP-4-dehydrorhamnose reductase activity
LCH97_RS11690	COG0800	Aldolase
LCH97_RS11700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LCH97_RS11710	COG0837	glucose binding
LCH97_RS11720	COG0166	Belongs to the GPI family
LCH97_RS11730	COG1451	nucleotide metabolic process
LCH97_RS11735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LCH97_RS11745	COG0009	L-threonylcarbamoyladenylate synthase
LCH97_RS11765	COG0138	bifunctional purine biosynthesis protein purh
LCH97_RS11785	COG3300	MHYT domain
LCH97_RS11785	COG5001	Diguanylate cyclase
LCH97_RS11800	COG0346	lactoylglutathione lyase activity
LCH97_RS11825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LCH97_RS11830	COG0508	dehydrogenase complex catalyzes the overall conversion of
LCH97_RS11840	COG4783	chaperone-mediated protein folding
LCH97_RS11845	COG0640	Transcriptional regulator
LCH97_RS11860	COG0288	reversible hydration of carbon dioxide
LCH97_RS11865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LCH97_RS11870	COG0799	negative regulation of ribosome biogenesis
LCH97_RS11875	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LCH97_RS11900	COG1466	dna polymerase III delta subunit
LCH97_RS11910	COG0495	leucyl-tRNA aminoacylation
LCH97_RS11920	COG0730	response to heat
LCH97_RS11930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LCH97_RS11960	COG4206	TonB-dependent receptor
LCH97_RS11965	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LCH97_RS11975	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LCH97_RS11985	COG0010	Belongs to the arginase family
LCH97_RS12000	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LCH97_RS12010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LCH97_RS12060	COG3128	pkhd-type hydroxylase
LCH97_RS12100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCH97_RS12140	COG1012	belongs to the aldehyde dehydrogenase family
LCH97_RS12145	COG3284	Transcriptional regulator
LCH97_RS12190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LCH97_RS12200	COG0584	glycerophosphoryl diester phosphodiesterase
LCH97_RS12220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LCH97_RS12225	COG0706	membrane insertase activity
LCH97_RS12230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LCH97_RS12235	COG0594	ribonuclease P activity
LCH97_RS12240	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LCH97_RS12245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LCH97_RS12290	COG0419	ATPase involved in DNA repair
LCH97_RS12310	COG1280	lysine exporter protein (LysE YggA)
LCH97_RS12315	COG1522	sequence-specific DNA binding
LCH97_RS12320	COG4735	regulation of single-species biofilm formation
LCH97_RS12330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LCH97_RS12335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH97_RS12340	COG0583	DNA-binding transcription factor activity
LCH97_RS12350	COG0488	(ABC) transporter
LCH97_RS12360	COG0784	Response regulator, receiver
LCH97_RS12360	COG2198	Histidine kinase
LCH97_RS12360	COG5002	protein histidine kinase activity
LCH97_RS12365	COG0697	spore germination
LCH97_RS12370	COG1522	sequence-specific DNA binding
LCH97_RS12375	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LCH97_RS12380	COG0006	proline dipeptidase activity
LCH97_RS12385	COG3135	benzoate transporter
LCH97_RS12390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCH97_RS12395	COG0583	DNA-binding transcription factor activity
LCH97_RS12400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LCH97_RS12430	COG0288	reversible hydration of carbon dioxide
LCH97_RS12435	COG0697	spore germination
LCH97_RS12440	COG0840	transmembrane signaling receptor activity
LCH97_RS12445	COG2204	response regulator
LCH97_RS12465	COG2358	TRAP transporter, solute receptor (TAXI family
LCH97_RS12485	COG0633	Ferredoxin
LCH97_RS12485	COG3217	Mosc domain protein beta barrel domain protein
LCH97_RS12510	COG2223	nitrite transmembrane transporter activity
LCH97_RS12530	COG2986	histidine ammonia-lyase
LCH97_RS12535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LCH97_RS12540	COG0010	Belongs to the arginase family
LCH97_RS12545	COG1228	amidohydrolase
LCH97_RS12570	COG1519	Transferase
LCH97_RS12595	COG4682	membrane
LCH97_RS12605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LCH97_RS12640	COG0697	spore germination
LCH97_RS12650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LCH97_RS12670	COG2962	Rard protein
LCH97_RS12725	COG2205	protein histidine kinase activity
LCH97_RS12735	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LCH97_RS12740	COG0540	Belongs to the ATCase OTCase family
LCH97_RS12775	COG2375	cellular response to nickel ion
LCH97_RS12780	COG1120	ATPase activity
LCH97_RS12785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCH97_RS12795	COG4774	siderophore transport
LCH97_RS12810	COG4628	conserved protein (DUF2132)
LCH97_RS12820	COG0840	transmembrane signaling receptor activity
LCH97_RS12845	COG1858	cytochrome C peroxidase
LCH97_RS12905	COG1522	sequence-specific DNA binding
LCH97_RS12930	COG0826	peptidase U32
LCH97_RS12960	COG2832	Protein of unknown function (DUF454)
LCH97_RS13020	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LCH97_RS13025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LCH97_RS13030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCH97_RS13035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LCH97_RS13045	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LCH97_RS13070	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LCH97_RS13095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LCH97_RS13100	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LCH97_RS13110	COG1305	Transglutaminase-like
LCH97_RS13125	COG2308	Evidence 4 Homologs of previously reported genes of
LCH97_RS13140	COG0415	Belongs to the DNA photolyase family
LCH97_RS13145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LCH97_RS13150	COG0583	DNA-binding transcription factor activity
LCH97_RS13160	COG0415	Belongs to the DNA photolyase family
LCH97_RS13180	COG0352	thiamine-phosphate diphosphorylase activity
LCH97_RS13185	COG0351	phosphomethylpyrimidine kinase
LCH97_RS13190	COG1773	rubredoxin
LCH97_RS13205	COG1981	membrane
LCH97_RS13215	COG2954	triphosphatase activity
LCH97_RS13230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LCH97_RS13235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LCH97_RS13255	COG2378	regulation of single-species biofilm formation
LCH97_RS13290	COG1858	cytochrome C peroxidase
LCH97_RS13320	COG1238	metal cluster binding
LCH97_RS13325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LCH97_RS13340	COG0765	amino acid transport
LCH97_RS13345	COG0765	amino acid transport
LCH97_RS13350	COG1126	abc transporter atp-binding protein
LCH97_RS13355	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LCH97_RS13380	COG0762	integral membrane protein
LCH97_RS13385	COG4654	Cytochrome c, class I
LCH97_RS13395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LCH97_RS13415	COG1280	lysine exporter protein (LysE YggA)
LCH97_RS13420	COG0126	phosphoglycerate kinase activity
LCH97_RS13425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LCH97_RS13430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LCH97_RS13460	COG0840	transmembrane signaling receptor activity
LCH97_RS13465	COG0583	DNA-binding transcription factor activity
LCH97_RS13475	COG1942	4-Oxalocrotonate Tautomerase
LCH97_RS13485	COG0165	Argininosuccinate lyase
LCH97_RS13490	COG4681	YaeQ
LCH97_RS13510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCH97_RS13520	COG2199	diguanylate cyclase activity
LCH97_RS13530	COG1247	-acetyltransferase
LCH97_RS13575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LCH97_RS13585	COG1333	cytochrome c biogenesis protein
LCH97_RS13590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LCH97_RS13600	COG2841	Protein conserved in bacteria
LCH97_RS13605	COG3706	GGDEF domain
LCH97_RS13615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCH97_RS13625	COG2959	enzyme of heme biosynthesis
LCH97_RS13635	COG0181	hydroxymethylbilane synthase activity
LCH97_RS13645	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LCH97_RS13670	COG1629	transport
LCH97_RS13675	COG3214	Protein conserved in bacteria
LCH97_RS13680	COG1132	(ABC) transporter
LCH97_RS13685	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LCH97_RS13700	COG5002	protein histidine kinase activity
LCH97_RS13700	COG0784	Response regulator, receiver
LCH97_RS13700	COG2198	Histidine kinase
LCH97_RS13705	COG3150	esterase
LCH97_RS13730	COG0697	spore germination
LCH97_RS13735	COG2188	Transcriptional regulator
LCH97_RS13740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LCH97_RS13745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LCH97_RS13750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LCH97_RS13750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCH97_RS13760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LCH97_RS13765	COG1522	sequence-specific DNA binding
LCH97_RS13785	COG0745	RESPONSE REGULATOR receiver
LCH97_RS13800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LCH97_RS13805	COG4221	oxidoreductase activity
LCH97_RS13815	COG3945	hemerythrin HHE cation binding domain
LCH97_RS13825	COG3781	membrane
LCH97_RS13835	COG3158	transport of potassium into the cell
LCH97_RS13845	COG1940	carbohydrate kinase activity
LCH97_RS13855	COG3842	ATPase activity
LCH97_RS13860	COG1472	Belongs to the glycosyl hydrolase 3 family
LCH97_RS13865	COG0395	ABC-type sugar transport system, permease component
LCH97_RS13870	COG1175	transmembrane transport
LCH97_RS13885	COG0442	prolyl-tRNA aminoacylation
LCH97_RS13890	COG0741	lytic transglycosylase activity
LCH97_RS13900	COG0028	Belongs to the TPP enzyme family
LCH97_RS13905	COG0440	acetolactate synthase activity
LCH97_RS13910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LCH97_RS13915	COG1183	phosphatidylcholine synthase activity
LCH97_RS13925	COG2819	hydrolase of the alpha beta superfamily
LCH97_RS13935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LCH97_RS13950	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LCH97_RS13955	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LCH97_RS13970	COG1999	signal sequence binding
LCH97_RS13975	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LCH97_RS13980	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LCH97_RS13985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LCH97_RS13995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LCH97_RS14000	COG0131	Imidazoleglycerol-phosphate dehydratase
LCH97_RS14005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LCH97_RS14010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LCH97_RS14015	COG0107	imidazoleglycerol-phosphate synthase activity
LCH97_RS14020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LCH97_RS14025	COG0140	phosphoribosyl-ATP diphosphatase activity
LCH97_RS14035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LCH97_RS14040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LCH97_RS14045	COG0805	protein transport
LCH97_RS14060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCH97_RS14080	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LCH97_RS14085	COG2823	Periplasmic or secreted lipoprotein
LCH97_RS14090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LCH97_RS14095	COG0792	nuclease activity
LCH97_RS14120	COG0084	hydrolase, TatD family'
LCH97_RS14140	COG2199	diguanylate cyclase activity
LCH97_RS14140	COG2202	Pas domain
LCH97_RS14140	COG2200	EAL domain
LCH97_RS14160	COG0445	tRNA wobble uridine modification
LCH97_RS14165	COG0357	Ribosomal RNA small subunit methyltransferase G
LCH97_RS14170	COG1192	Involved in chromosome partitioning
LCH97_RS14185	COG0356	it plays a direct role in the translocation of protons across the membrane
LCH97_RS14195	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LCH97_RS14200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LCH97_RS14205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LCH97_RS14210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LCH97_RS14215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LCH97_RS14220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LCH97_RS14225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LCH97_RS14230	COG1349	DNA-binding transcription factor activity
LCH97_RS14235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LCH97_RS14250	COG2824	Alkylphosphonate utilization operon protein PhnA
LCH97_RS14260	COG1505	serine-type exopeptidase activity
LCH97_RS14270	COG0583	DNA-binding transcription factor activity
LCH97_RS14285	COG0730	response to heat
LCH97_RS14305	COG0840	transmembrane signaling receptor activity
LCH97_RS14310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LCH97_RS14320	COG0840	transmembrane signaling receptor activity
LCH97_RS14325	COG1028	Short-chain dehydrogenase reductase Sdr
LCH97_RS14330	COG0424	maF-like protein
LCH97_RS14335	COG1530	ribonuclease E activity
LCH97_RS14340	COG1045	serine acetyltransferase
LCH97_RS14360	COG0456	acetyltransferase
LCH97_RS14385	COG0037	tRNA processing
LCH97_RS14390	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LCH97_RS14460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LCH97_RS14465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LCH97_RS14490	COG1695	Transcriptional regulator
LCH97_RS14500	COG0583	DNA-binding transcription factor activity
LCH97_RS14505	COG1027	Aspartate ammonia-lyase
LCH97_RS14510	COG1301	dicarboxylic acid transport
LCH97_RS14520	COG3171	Protein conserved in bacteria
LCH97_RS14530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LCH97_RS14535	COG3047	cAMP biosynthetic process
LCH97_RS14585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LCH97_RS14590	COG0708	Exodeoxyribonuclease III
LCH97_RS14615	COG0408	coproporphyrinogen oxidase activity
LCH97_RS14620	COG0840	transmembrane signaling receptor activity
LCH97_RS14625	COG0745	RESPONSE REGULATOR receiver
LCH97_RS14635	COG2198	Histidine kinase
LCH97_RS14635	COG0643	Histidine kinase
LCH97_RS14645	COG0835	chemotaxis
LCH97_RS14655	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LCH97_RS14660	COG2201	protein-glutamate methylesterase activity
LCH97_RS14665	COG2202	Pas domain
LCH97_RS14665	COG2200	EAL domain
LCH97_RS14665	COG2199	diguanylate cyclase activity
LCH97_RS14675	COG2205	protein histidine kinase activity
LCH97_RS14680	COG0745	RESPONSE REGULATOR receiver
LCH97_RS14705	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LCH97_RS14705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LCH97_RS14725	COG1648	precorrin-2 dehydrogenase activity
LCH97_RS14725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LCH97_RS14740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LCH97_RS14745	COG0859	PFAM glycosyl transferase family 9
LCH97_RS14750	COG0438	transferase activity, transferring glycosyl groups
LCH97_RS14765	COG0438	transferase activity, transferring glycosyl groups
LCH97_RS14770	COG1132	(ABC) transporter
LCH97_RS14795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LCH97_RS14800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LCH97_RS14855	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LCH97_RS14865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LCH97_RS14870	COG2813	Specifically methylates the guanine in position
LCH97_RS14870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LCH97_RS14875	COG2223	nitrite transmembrane transporter activity
LCH97_RS14885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LCH97_RS14900	COG1959	2 iron, 2 sulfur cluster binding
LCH97_RS14900	COG1295	ribonuclease BN
LCH97_RS14915	COG0142	geranyltranstransferase activity
LCH97_RS14920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LCH97_RS14925	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LCH97_RS14930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LCH97_RS14945	COG1196	nuclear chromosome segregation
LCH97_RS14950	COG0501	Belongs to the peptidase M48B family
LCH97_RS14960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCH97_RS14980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LCH97_RS14995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LCH97_RS15000	COG0339	signal peptide processing
LCH97_RS15020	COG1280	lysine exporter protein (LysE YggA)
LCH97_RS15030	COG1278	Cold shock
LCH97_RS15045	COG1752	Esterase of the alpha-beta hydrolase superfamily
LCH97_RS15050	COG0438	transferase activity, transferring glycosyl groups
LCH97_RS15080	COG1294	oxidase, subunit
LCH97_RS15125	COG4208	sulfate ABC transporter
LCH97_RS15130	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LCH97_RS15135	COG0583	DNA-binding transcription factor activity
LCH97_RS15160	COG0473	3-isopropylmalate dehydrogenase activity
LCH97_RS15180	COG0277	FAD linked oxidase domain protein
LCH97_RS15200	COG1012	belongs to the aldehyde dehydrogenase family
LCH97_RS15205	COG2070	2-Nitropropane dioxygenase
LCH97_RS15215	COG0583	DNA-binding transcription factor activity
LCH97_RS15220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH97_RS15230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LCH97_RS15235	COG1074	ATP-dependent DNA helicase activity
LCH97_RS15250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LCH97_RS15290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LCH97_RS15295	COG1301	dicarboxylic acid transport
LCH97_RS15305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LCH97_RS15315	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LCH97_RS15320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LCH97_RS15335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LCH97_RS15340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LCH97_RS15345	COG0193	aminoacyl-tRNA hydrolase activity
LCH97_RS15350	COG0012	GTP binding
LCH97_RS15360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LCH97_RS15365	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LCH97_RS15370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LCH97_RS15380	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LCH97_RS15395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LCH97_RS15400	COG0306	phosphate transporter
LCH97_RS15405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LCH97_RS15410	COG0581	inorganic phosphate transmembrane transporter activity
LCH97_RS15420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LCH97_RS15425	COG0149	triose-phosphate isomerase activity
LCH97_RS15430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LCH97_RS15440	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCH97_RS15445	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCH97_RS15450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCH97_RS15455	COG0649	NAD binding
LCH97_RS15460	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LCH97_RS15475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LCH97_RS15480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCH97_RS15490	COG0713	ATP synthesis coupled electron transport
LCH97_RS15505	COG1007	ATP synthesis coupled electron transport
LCH97_RS15515	COG1560	Kdo2-lipid A biosynthetic process
LCH97_RS15525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LCH97_RS15530	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LCH97_RS15535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LCH97_RS15540	COG3447	MASE1 domain protein
LCH97_RS15540	COG5001	Diguanylate cyclase
LCH97_RS15540	COG5002	protein histidine kinase activity
LCH97_RS15545	COG1522	sequence-specific DNA binding
LCH97_RS15560	COG0625	glutathione transferase activity
LCH97_RS15640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LCH97_RS15645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LCH97_RS15660	COG3959	Transketolase, thiamine diphosphate binding domain
LCH97_RS15665	COG3958	Transketolase
LCH97_RS15690	COG1215	transferase activity, transferring glycosyl groups
LCH97_RS15720	COG2095	MarC family integral membrane protein
LCH97_RS15735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LCH97_RS15740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LCH97_RS15745	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LCH97_RS15750	COG0813	purine-nucleoside phosphorylase activity
LCH97_RS15755	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LCH97_RS15760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LCH97_RS15765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LCH97_RS15770	COG0316	Belongs to the HesB IscA family
LCH97_RS15780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH97_RS15790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LCH97_RS15795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LCH97_RS15800	COG0242	peptide deformylase activity
LCH97_RS15805	COG0123	including yeast histone deacetylase and acetoin utilization protein
LCH97_RS15810	COG0714	Associated with various cellular activities
LCH97_RS15830	COG4942	peptidase
LCH97_RS15830	COG1388	LysM domain
LCH97_RS15835	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LCH97_RS15840	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LCH97_RS15845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LCH97_RS15850	COG0045	succinate-CoA ligase (ADP-forming) activity
LCH97_RS15850	COG1042	CoA-binding domain protein
LCH97_RS15850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCH97_RS15855	COG0228	four-way junction DNA binding
LCH97_RS15860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LCH97_RS15865	COG0336	Belongs to the RNA methyltransferase TrmD family
LCH97_RS15870	COG0335	large ribosomal subunit rRNA binding
LCH97_RS15880	COG0542	response to heat
LCH97_RS15885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LCH97_RS15890	COG1278	Cold shock
LCH97_RS15895	COG0477	Major facilitator Superfamily
LCH97_RS15905	COG0538	isocitrate dehydrogenase activity
LCH97_RS15920	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LCH97_RS15930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LCH97_RS15945	COG1271	oxidase subunit
LCH97_RS15950	COG1294	oxidase, subunit
LCH97_RS15965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LCH97_RS15985	COG0798	PFAM Bile acid sodium symporter
LCH97_RS16005	COG2205	protein histidine kinase activity
LCH97_RS16035	COG2010	Cytochrome c
LCH97_RS16055	COG0840	transmembrane signaling receptor activity
LCH97_RS16060	COG1763	Mo-molybdopterin cofactor biosynthetic process
LCH97_RS16070	COG0314	molybdopterin synthase activity
LCH97_RS16080	COG2223	nitrite transmembrane transporter activity
LCH97_RS16085	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LCH97_RS16090	COG1140	nitrate reductase beta subunit
LCH97_RS16095	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LCH97_RS16100	COG2181	nitrate reductase activity
LCH97_RS16105	COG0303	'Molybdopterin
LCH97_RS16110	COG0315	cyclic pyranopterin monophosphate synthase activity
LCH97_RS16125	COG2197	response regulator
LCH97_RS16130	COG3850	Histidine kinase
LCH97_RS16135	COG0288	reversible hydration of carbon dioxide
LCH97_RS16155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LCH97_RS16155	COG1648	precorrin-2 dehydrogenase activity
LCH97_RS16160	COG2010	Cytochrome c
LCH97_RS16170	COG1845	cytochrome c oxidase, subunit III
LCH97_RS16180	COG0714	Associated with various cellular activities
LCH97_RS16200	COG4654	Cytochrome c, class I
LCH97_RS16205	COG2010	Cytochrome c
LCH97_RS16250	COG0826	peptidase U32
LCH97_RS16260	COG3154	lipid carrier protein
LCH97_RS16265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LCH97_RS16270	COG4149	molybdate abc transporter
LCH97_RS16315	COG3596	GTP binding
LCH97_RS16345	COG4149	molybdate abc transporter
LCH97_RS16350	COG0725	ABC transporter, periplasmic molybdate-binding protein
LCH97_RS16410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LCH97_RS16415	COG2022	thiamine diphosphate biosynthetic process
LCH97_RS16425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LCH97_RS16430	COG1758	RNA polymerase activity
LCH97_RS16435	COG0194	GDP metabolic process
LCH97_RS16440	COG2252	PERMEase
LCH97_RS16445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LCH97_RS16450	COG0840	transmembrane signaling receptor activity
LCH97_RS16455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LCH97_RS16465	COG0842	Transport permease protein
LCH97_RS16470	COG1131	(ABC) transporter
LCH97_RS16490	COG1538	Outer membrane efflux protein
LCH97_RS16495	COG1132	(ABC) transporter
LCH97_RS16500	COG1132	(ABC) transporter
LCH97_RS16520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LCH97_RS16525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LCH97_RS16530	COG1127	ABC transporter
LCH97_RS16535	COG2171	N-acyltransferase activity
LCH97_RS16540	COG0436	Aminotransferase
LCH97_RS16570	COG2900	Belongs to the SlyX family
LCH97_RS16575	COG2056	Na+-H+ antiporter family
LCH97_RS16585	COG2268	Band 7 protein
LCH97_RS16590	COG1585	Membrane protein implicated in regulation of membrane protease activity
LCH97_RS16615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LCH97_RS16625	COG0745	RESPONSE REGULATOR receiver
LCH97_RS16630	COG2205	protein histidine kinase activity
LCH97_RS16635	COG1192	Involved in chromosome partitioning
LCH97_RS16645	COG0514	ATP-dependent DNA helicase (RecQ)
LCH97_RS16650	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LCH97_RS16685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LCH97_RS16690	COG0583	DNA-binding transcription factor activity
LCH97_RS16705	COG3852	Histidine kinase
LCH97_RS16715	COG0174	glutamine synthetase
LCH97_RS16725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LCH97_RS16730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LCH97_RS16735	COG2239	Acts as a magnesium transporter
LCH97_RS16755	COG2850	peptidyl-arginine hydroxylation
LCH97_RS16770	COG0586	Pfam SNARE associated Golgi protein
LCH97_RS16785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LCH97_RS16800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LCH97_RS16820	COG4221	oxidoreductase activity
LCH97_RS16840	COG0386	Belongs to the glutathione peroxidase family
LCH97_RS16845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LCH97_RS16855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LCH97_RS16855	COG0543	2 iron, 2 sulfur cluster binding
LCH97_RS16860	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LCH97_RS16890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LCH97_RS16895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LCH97_RS16900	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LCH97_RS16905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LCH97_RS16910	COG0488	(ABC) transporter
LCH97_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
LCH97_RS16920	COG0583	DNA-binding transcription factor activity
LCH97_RS16925	COG0175	sulfate reduction
LCH97_RS16945	COG0196	riboflavin kinase activity
LCH97_RS16950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LCH97_RS16955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LCH97_RS16960	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LCH97_RS16990	COG1660	Displays ATPase and GTPase activities
LCH97_RS16995	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LCH97_RS17010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LCH97_RS17015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LCH97_RS17020	COG1137	ATPase activity
LCH97_RS17025	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LCH97_RS17035	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LCH97_RS17060	COG0733	neurotransmitter:sodium symporter activity
LCH97_RS17065	COG0252	asparaginase activity
LCH97_RS17075	COG2501	S4 domain
LCH97_RS17085	COG0613	PHP domain protein
LCH97_RS17090	COG0009	L-threonylcarbamoyladenylate synthase
LCH97_RS17095	COG1994	Peptidase M50
LCH97_RS17100	COG0180	Tryptophanyl-tRNA synthetase
LCH97_RS17110	COG1742	UPF0060 membrane protein
LCH97_RS17120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LCH97_RS17140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCH97_RS17145	COG0583	DNA-binding transcription factor activity
LCH97_RS17150	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LCH97_RS17160	COG0850	regulation of cytokinetic process
LCH97_RS17175	COG0583	DNA-binding transcription factor activity
LCH97_RS17185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LCH97_RS17190	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LCH97_RS17200	COG4302	ethanolamine ammonia-lyase activity
LCH97_RS17210	COG0531	amino acid
LCH97_RS17240	COG2895	sulfate adenylyltransferase (ATP) activity
LCH97_RS17245	COG0175	sulfate reduction
LCH97_RS17250	COG3437	response regulator, receiver
LCH97_RS17255	COG5002	protein histidine kinase activity
LCH97_RS17255	COG2205	protein histidine kinase activity
LCH97_RS17255	COG0784	Response regulator, receiver
LCH97_RS17290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LCH97_RS17300	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LCH97_RS17315	COG5002	protein histidine kinase activity
LCH97_RS17320	COG0745	RESPONSE REGULATOR receiver
LCH97_RS17350	COG3813	Protein conserved in bacteria
LCH97_RS17385	COG2197	response regulator
LCH97_RS17390	COG0642	Histidine kinase
LCH97_RS17400	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LCH97_RS17415	COG0513	Belongs to the DEAD box helicase family
LCH97_RS17435	COG0784	Response regulator, receiver
LCH97_RS17435	COG2205	protein histidine kinase activity
LCH97_RS17435	COG5002	protein histidine kinase activity
LCH97_RS17440	COG0752	glycyl-tRNA synthetase alpha subunit
LCH97_RS17480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LCH97_RS17485	COG3706	GGDEF domain
LCH97_RS17495	COG0560	Phosphoserine phosphatase
LCH97_RS17510	COG3220	belongs to the UPF0276 family
LCH97_RS17520	COG0602	queuosine metabolic process
LCH97_RS17535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LCH97_RS17540	COG1597	lipid kinase activity
LCH97_RS17555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LCH97_RS17560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LCH97_RS17570	COG1902	pentaerythritol trinitrate reductase activity
LCH97_RS17575	COG0778	Nitroreductase
LCH97_RS17580	COG1309	transcriptional regulator
LCH97_RS17590	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LCH97_RS17595	COG0725	ABC transporter, periplasmic molybdate-binding protein
LCH97_RS17600	COG4149	molybdate abc transporter
LCH97_RS17615	COG4702	Belongs to the UPF0303 family
LCH97_RS17620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LCH97_RS17655	COG0840	transmembrane signaling receptor activity
LCH97_RS17660	COG4172	Belongs to the ABC transporter superfamily
LCH97_RS17675	COG0747	negative chemotaxis
LCH97_RS17680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LCH97_RS17685	COG4139	cobalamin transport
LCH97_RS17690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCH97_RS17695	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LCH97_RS17700	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LCH97_RS17705	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LCH97_RS17710	COG2205	protein histidine kinase activity
LCH97_RS17715	COG0745	RESPONSE REGULATOR receiver
LCH97_RS17730	COG2957	Belongs to the agmatine deiminase family
LCH97_RS17735	COG2957	Belongs to the agmatine deiminase family
LCH97_RS17755	COG0583	DNA-binding transcription factor activity
LCH97_RS17775	COG0436	Aminotransferase
LCH97_RS17785	COG1704	LemA family
LCH97_RS17800	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LCH97_RS17805	COG0424	maF-like protein
LCH97_RS17810	COG1399	metal-binding, possibly nucleic acid-binding protein
LCH97_RS17815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LCH97_RS17860	COG5001	Diguanylate cyclase
LCH97_RS17860	COG3300	MHYT domain
LCH97_RS17890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LCH97_RS18015	COG4974	Belongs to the 'phage' integrase family
LCH97_RS18125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LCH97_RS18135	COG1475	DNA binding
LCH97_RS18140	COG1192	Involved in chromosome partitioning
LCH97_RS18290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LCH97_RS18325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LCH97_RS18450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LCH97_RS18495	COG2974	May be involved in recombination
LCH97_RS18640	COG0840	transmembrane signaling receptor activity
LCH97_RS18685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LCH97_RS18720	COG3210	domain, Protein
LCH97_RS18725	COG3210	domain, Protein
LCH97_RS18750	COG0720	synthase